Optimal transcostal high-intensity focused ultrasound with combined real-time 3D movement tracking and correction

International Nuclear Information System (INIS)

Marquet, F; Aubry, J F; Pernot, M; Fink, M; Tanter, M

2011-01-01

Recent studies have demonstrated the feasibility of transcostal high intensity focused ultrasound (HIFU) treatment in liver. However, two factors limit thermal necrosis of the liver through the ribs: the energy deposition at focus is decreased by the respiratory movement of the liver and the energy deposition on the skin is increased by the presence of highly absorbing bone structures. Ex vivo ablations were conducted to validate the feasibility of a transcostal real-time 3D movement tracking and correction mode. Experiments were conducted through a chest phantom made of three human ribs immersed in water and were placed in front of a 300 element array working at 1 MHz. A binarized apodization law introduced recently in order to spare the rib cage during treatment has been extended here with real-time electronic steering of the beam. Thermal simulations have been conducted to determine the steering limits. In vivo 3D-movement detection was performed on pigs using an ultrasonic sequence. The maximum error on the transcostal motion detection was measured to be 0.09 ± 0.097 mm on the anterior–posterior axis. Finally, a complete sequence was developed combining real-time 3D transcostal movement correction and spiral trajectory of the HIFU beam, allowing the system to treat larger areas with optimized efficiency. Lesions as large as 1 cm in diameter have been produced at focus in excised liver, whereas no necroses could be obtained with the same emitted power without correcting the movement of the tissue sample.

Time-resolved diffusion tomographic 2D and 3D imaging in highly scattering turbid media

Science.gov (United States)

Alfano, Robert R. (Inventor); Cai, Wei (Inventor); Gayen, Swapan K. (Inventor)

2000-01-01

A method for imaging objects in highly scattering turbid media. According to one embodiment of the invention, the method involves using a plurality of intersecting source/detectors sets and time-resolving equipment to generate a plurality of time-resolved intensity curves for the diffusive component of light emergent from the medium. For each of the curves, the intensities at a plurality of times are then inputted into the following inverse reconstruction algorithm to form an image of the medium: wherein W is a matrix relating output at source and detector positions r.sub.s and r.sub.d, at time t, to position r, .LAMBDA. is a regularization matrix, chosen for convenience to be diagonal, but selected in a way related to the ratio of the noise, to fluctuations in the absorption (or diffusion) X.sub.j that we are trying to determine: .LAMBDA..sub.ij =.lambda..sub.j .delta..sub.ij with .lambda..sub.j =/ Y is the data collected at the detectors, and X.sup.k is the kth iterate toward the desired absorption information. An algorithm, which combines a two dimensional (2D) matrix inversion with a one-dimensional (1D) Fourier transform inversion is used to obtain images of three dimensional hidden objects in turbid scattering media.

Accelerator-based intense neutron source for materials R ampersand D

International Nuclear Information System (INIS)

Jameson, R.A.

1990-01-01

Accelerator-based neutron sources for R ampersand D of materials in nuclear energy systems, including fusion reactors, can provide sufficient neutron flux, flux-volume, fluence and other attractive features for many aspects of materials research. The neutron spectrum produced from the D-Li reaction has been judged useful for many basic materials research problems, and to be a satisfactory approximation to that of the fusion process. The technology of high-intensity linear accelerators can readily be applied to provide the deuteron beam for the neutron source. Earlier applications included the Los Alamos Meson Physics Facility and the Fusion Materials Irradiation Test facility prototype. The key features of today's advanced accelerator technology are presented to illustrate the present state-of-the-art in terms of improved understanding of basic physical principles and engineering technique, and to show how these advances can be applied to present demands in a timely manner. These features include how to produce an intense beam current with the high quality required to minimize beam losses along the accelerator and transport system that could cause maintenance difficulties, by controlling the beam emittance through proper choice of the operating frequency, balancing of the forces acting on the beam, and realization in practical hardware. A most interesting aspect for materials researchers is the increased flexibility and opportunities for experimental configurations that a modern accelerator-based source could add to the set of available tools. 8 refs., 5 figs

Humectancies of d-tagatose and d-sorbitol.

Science.gov (United States)

Lu, Y

2001-06-01

Most toothpastes contain either d-sorbitol or glycerin, or both, as humectants. Both compounds are about half as sweet as sucrose. This level of sweetness is not as intense as desired by most people when brushing teeth. Therefore, many brands of toothpaste add saccharin, a high-intensity sweetener, to increase product sweetness to acceptable levels. While this combination provides the required bulk, humectancy and sweetness, the last characteristic suffers from the widely perceived metallic, or bitter, aftertaste of saccharin. d-tagatose, a full-bulk, low-calorie, sucrose-like sweetener with about twice the sweetness of d-sorbitol, and which does not promote tooth decay, holds promise as a sole sweetener for toothpastes. The only untested aspect of this use of d-tagatose was its humectancy, the characteristic that retains the required level of moisture in toothpaste. The current study was made to investigate this important property, to make a direct comparison of the humectancies of d-tagatose and d-sorbitol as pure substances, and to determine whether the humectancy of d-tagatose is sufficient to counter the crystallizing potentiation of the abrasives used in toothpastes. The humectancies of d-tagatose and d-sorbitol were tested through measuring their water activity (a(w)) vs. water content. By comparing their desorption curves, d-tagatose was seen to have a humectancy equal to that of d-sorbitol when a(w) in the d-tagatose solution was above 0.62. d-Tagatose was then tested in toothpastes containing typical abrasives to determine whether the abrasives would induce crystallization of the sweetener. The addition of 20-25% wt/wt of d-tagatose to the Tom of Maine's toothpastes imparted a satisfactory sweetness. It was found that, within that range of concentration, d-tagatose retained its humectancy, and did not crystallize in the popular brands of commercial toothpastes tested. Thus, d-tagatose could be used as a humectant sweetener in toothpastes, although further

Transition from 2-D radiotherapy to 3-D conformal and intensity modulated radiotherapy

International Nuclear Information System (INIS)

2008-05-01

Cancer is one of the leading causes of death globally and radiotherapy is currently an essential component in the management of cancer patients, either alone or in combination with surgery or chemotherapy, both for cure or palliation. It is now recognized that safe and effective radiotherapy service needs not only substantial capital investment in radiotherapy equipment and specially designed facilities but also continuous investment in maintenance and upgrading of the equipment to comply with the technical progress, but also in training the staff. The recent IAEA-TECDOC publication 'Setting up a Radiotherapy Programme: Clinical, Medical Physics, Radiation Protection and Safety Aspects' provides general guidelines for designing and implementing radiotherapy services in Member States. Advances in computer technology have enabled the possibility of transitioning from basic 2- dimensional treatment planning and delivery (2-D radiotherapy) to a more sophisticated approach with 3-dimensional conformal radiotherapy (3-D CRT). Whereas 2-D radiotherapy can be applied with simple equipment, infrastructure and training, transfer to 3-D conformal treatments requires more resources in technology, equipment, staff and training. A novel radiation treatment approach using Intensity Modulated Radiation Therapy (IMRT) that optimizes the delivery of radiation to irregularly shaped tumour volumes demands even more sophisticated equipment and seamless teamwork, and consequentially more resources, advanced training and more time for treatment planning and verification of dose delivery than 3-D CRT. Whereas 3-D CRT can be considered as a standard, IMRT is still evolving. Due to the increased interest of Member States to the modern application of radiotherapy the IAEA has received a number of requests for guidance coming from radiotherapy departments that wish to upgrade their facilities to 3-D CRT and IMRT through Technical Cooperation programme. These requests are expected to increase

R&D cooperation versus R&D subcontracting: empirical evidence from French survey data.

OpenAIRE

Estelle Dhont-Peltrault; Etienne Pfister

2007-01-01

This paper uses a survey of French firms active in R&D to identify the determinants of R&D outsourcing and of the ensuing trade-off between R&D subcontracting and R&D cooperation. Internal R&D expenditures increase both the probability of outsourcing and the number of R&D partners. Investment in fundamental R&D, group belonging, and the sector’s high R&D intensity positively influences the probability of R&D outsourcing but have less impact on the number of partners. R&D subcontracting is mor...

IGUANA A high-performance 2D and 3D visualisation system

CERN Document Server

Alverson, G; Muzaffar, S; Osborne, I; Taylor, L; Tuura, L A

2004-01-01

The IGUANA project has developed visualisation tools for multiple high-energy experiments. At the core of IGUANA is a generic, high- performance visualisation system based on OpenInventor and OpenGL. This paper describes the back-end and a feature-rich 3D visualisation system built on it, as well as a new 2D visualisation system that can automatically generate 2D views from 3D data, for example to produce R/Z or X/Y detector displays from existing 3D display with little effort. IGUANA has collaborated with the open-source gl2ps project to create a high-quality vector postscript output that can produce true vector graphics output from any OpenGL 2D or 3D display, complete with surface shading and culling of invisible surfaces. We describe how it works. We also describe how one can measure the memory and performance costs of various OpenInventor constructs and how to test scene graphs. We present good patterns to follow and bad patterns to avoid. We have added more advanced tools such as per-object clipping, sl...

2-D Modelling of Long Period Variations of Galactic Cosmic Ray Intensity

International Nuclear Information System (INIS)

Siluszyk, M; Iskra, K; Alania, M

2015-01-01

A new two-dimensional (2-D) time dependent model describing long-period variations of the Galactic Cosmic Ray (GCR) intensity has been developed. New approximations for the changes of the magnitude B of the Interplanetary Magnetic Field (IMF), the tilt angle δ of the Heliospheric Neutral Sheet (HNS) and drift effects of the GCR particles have been included into the model. Moreover, temporal changes of the exponent γ expressing the power law - rigidity dependence of the amplitudes of the 11-year variation of the GCR intensity have been added. We show that changes of the expected GCR particle density precedes changes of the GCR intensity measured by the Moscow Neutron (MN) monitor by about 18 months. So ∼18 months can be taken as an effective delay time between the expected intensity caused by the combined influence of the changes of the parameters implemented in the time-dependent 2-D model and the GCR intensity measured by neutron monitors during the 21 cycle of solar activity. (paper)

GIS Data Based Automatic High-Fidelity 3D Road Network Modeling

Science.gov (United States)

Wang, Jie; Shen, Yuzhong

2011-01-01

3D road models are widely used in many computer applications such as racing games and driving simulations_ However, almost all high-fidelity 3D road models were generated manually by professional artists at the expense of intensive labor. There are very few existing methods for automatically generating 3D high-fidelity road networks, especially those existing in the real world. This paper presents a novel approach thai can automatically produce 3D high-fidelity road network models from real 2D road GIS data that mainly contain road. centerline in formation. The proposed method first builds parametric representations of the road centerlines through segmentation and fitting . A basic set of civil engineering rules (e.g., cross slope, superelevation, grade) for road design are then selected in order to generate realistic road surfaces in compliance with these rules. While the proposed method applies to any types of roads, this paper mainly addresses automatic generation of complex traffic interchanges and intersections which are the most sophisticated elements in the road networks

Safety and deterministic failure analyses in high-beta D-D tokamak reactors

International Nuclear Information System (INIS)

Selcow, E.C.

1984-01-01

Safety and deterministic failure analyses were performed to compare major component failure characteristics for different high-beta D-D tokamak reactors. The primary focus was on evaluating damage to the reactor facility. The analyses also considered potential hazards to the general public and operational personnel. Parametric designs of high-beta D-D tokamak reactors were developed, using WILDCAT as the reference. The size, and toroidal field strength were reduced, and the fusion power increased in an independent manner. These changes were expected to improve the economics of D-D tokamaks. Issues examined using these designs were radiation induced failurs, radiation safety, first wall failure from plasma disruptions, and toroidal field magnet coil failure

Subnuclear foci quantification using high-throughput 3D image cytometry

Science.gov (United States)

Wadduwage, Dushan N.; Parrish, Marcus; Choi, Heejin; Engelward, Bevin P.; Matsudaira, Paul; So, Peter T. C.

2015-07-01

Ionising radiation causes various types of DNA damages including double strand breaks (DSBs). DSBs are often recognized by DNA repair protein ATM which forms gamma-H2AX foci at the site of the DSBs that can be visualized using immunohistochemistry. However most of such experiments are of low throughput in terms of imaging and image analysis techniques. Most of the studies still use manual counting or classification. Hence they are limited to counting a low number of foci per cell (5 foci per nucleus) as the quantification process is extremely labour intensive. Therefore we have developed a high throughput instrumentation and computational pipeline specialized for gamma-H2AX foci quantification. A population of cells with highly clustered foci inside nuclei were imaged, in 3D with submicron resolution, using an in-house developed high throughput image cytometer. Imaging speeds as high as 800 cells/second in 3D were achieved by using HiLo wide-field depth resolved imaging and a remote z-scanning technique. Then the number of foci per cell nucleus were quantified using a 3D extended maxima transform based algorithm. Our results suggests that while most of the other 2D imaging and manual quantification studies can count only up to about 5 foci per nucleus our method is capable of counting more than 100. Moreover we show that 3D analysis is significantly superior compared to the 2D techniques.

IGUANA: a high-performance 2D and 3D visualisation system

Energy Technology Data Exchange (ETDEWEB)

Alverson, G. [Department of Physics, Northeastern University, Boston, MA 02115 (United States); Eulisse, G. [Department of Physics, Northeastern University, Boston, MA 02115 (United States); Muzaffar, S. [Department of Physics, Northeastern University, Boston, MA 02115 (United States); Osborne, I. [Department of Physics, Northeastern University, Boston, MA 02115 (United States); Taylor, L. [Department of Physics, Northeastern University, Boston, MA 02115 (United States)]. E-mail: lucas.taylor@cern.ch; Tuura, L.A. [Department of Physics, Northeastern University, Boston, MA 02115 (United States)

2004-11-21

The IGUANA project has developed visualisation tools for multiple high-energy experiments. At the core of IGUANA is a generic, high-performance visualisation system based on OpenInventor and OpenGL. This paper describes the back-end and a feature-rich 3D visualisation system built on it, as well as a new 2D visualisation system that can automatically generate 2D views from 3D data, for example to produce R/Z or X/Y detector displays from existing 3D display with little effort. IGUANA has collaborated with the open-source gl2ps project to create a high-quality vector postscript output that can produce true vector graphics output from any OpenGL 2D or 3D display, complete with surface shading and culling of invisible surfaces. We describe how it works. We also describe how one can measure the memory and performance costs of various OpenInventor constructs and how to test scene graphs. We present good patterns to follow and bad patterns to avoid. We have added more advanced tools such as per-object clipping, slicing, lighting or animation, as well as multiple linked views with OpenInventor, and describe them in this paper. We give details on how to edit object appearance efficiently and easily, and even dynamically as a function of object properties, with instant visual feedback to the user.

IGUANA: a high-performance 2D and 3D visualisation system

International Nuclear Information System (INIS)

Alverson, G.; Eulisse, G.; Muzaffar, S.; Osborne, I.; Taylor, L.; Tuura, L.A.

2004-01-01

The IGUANA project has developed visualisation tools for multiple high-energy experiments. At the core of IGUANA is a generic, high-performance visualisation system based on OpenInventor and OpenGL. This paper describes the back-end and a feature-rich 3D visualisation system built on it, as well as a new 2D visualisation system that can automatically generate 2D views from 3D data, for example to produce R/Z or X/Y detector displays from existing 3D display with little effort. IGUANA has collaborated with the open-source gl2ps project to create a high-quality vector postscript output that can produce true vector graphics output from any OpenGL 2D or 3D display, complete with surface shading and culling of invisible surfaces. We describe how it works. We also describe how one can measure the memory and performance costs of various OpenInventor constructs and how to test scene graphs. We present good patterns to follow and bad patterns to avoid. We have added more advanced tools such as per-object clipping, slicing, lighting or animation, as well as multiple linked views with OpenInventor, and describe them in this paper. We give details on how to edit object appearance efficiently and easily, and even dynamically as a function of object properties, with instant visual feedback to the user

Exploratory Study of 4D versus 3D Robust Optimization in Intensity Modulated Proton Therapy for Lung Cancer

Energy Technology Data Exchange (ETDEWEB)

Liu, Wei, E-mail: Liu.Wei@mayo.edu [Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona (United States); Schild, Steven E. [Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona (United States); Chang, Joe Y.; Liao, Zhongxing [Department of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chang, Yu-Hui [Division of Health Sciences Research, Mayo Clinic Arizona, Phoenix, Arizona (United States); Wen, Zhifei [Department of Radiation Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Shen, Jiajian; Stoker, Joshua B.; Ding, Xiaoning; Hu, Yanle [Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona (United States); Sahoo, Narayan [Department of Radiation Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Herman, Michael G. [Department of Radiation Oncology, Mayo Clinic Rochester, Rochester, Minnesota (United States); Vargas, Carlos; Keole, Sameer; Wong, William; Bues, Martin [Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona (United States)

2016-05-01

Purpose: The purpose of this study was to compare the impact of uncertainties and interplay on 3-dimensional (3D) and 4D robustly optimized intensity modulated proton therapy (IMPT) plans for lung cancer in an exploratory methodology study. Methods and Materials: IMPT plans were created for 11 nonrandomly selected non-small cell lung cancer (NSCLC) cases: 3D robustly optimized plans on average CTs with internal gross tumor volume density overridden to irradiate internal target volume, and 4D robustly optimized plans on 4D computed tomography (CT) to irradiate clinical target volume (CTV). Regular fractionation (66 Gy [relative biological effectiveness; RBE] in 33 fractions) was considered. In 4D optimization, the CTV of individual phases received nonuniform doses to achieve a uniform cumulative dose. The root-mean-square dose-volume histograms (RVH) measured the sensitivity of the dose to uncertainties, and the areas under the RVH curve (AUCs) were used to evaluate plan robustness. Dose evaluation software modeled time-dependent spot delivery to incorporate interplay effect with randomized starting phases of each field per fraction. Dose-volume histogram (DVH) indices comparing CTV coverage, homogeneity, and normal tissue sparing were evaluated using Wilcoxon signed rank test. Results: 4D robust optimization plans led to smaller AUC for CTV (14.26 vs 18.61, respectively; P=.001), better CTV coverage (Gy [RBE]) (D{sub 95%} CTV: 60.6 vs 55.2, respectively; P=.001), and better CTV homogeneity (D{sub 5%}-D{sub 95%} CTV: 10.3 vs 17.7, resspectively; P=.002) in the face of uncertainties. With interplay effect considered, 4D robust optimization produced plans with better target coverage (D{sub 95%} CTV: 64.5 vs 63.8, respectively; P=.0068), comparable target homogeneity, and comparable normal tissue protection. The benefits from 4D robust optimization were most obvious for the 2 typical stage III lung cancer patients. Conclusions: Our exploratory methodology study showed

D1A, a high resolution neutron powder diffractometer with a bank of mylar collimators

International Nuclear Information System (INIS)

Hewat, A.W.; Bailey, I.

1976-01-01

This paper describes a first attempt at following the design criteria set out earlier for a high resolution conventional powder diffractometer. An existing machine, D1A, has been modified using a bank of ten high pressure 3 He counters and almost perfect 10minutes of arc mylar foil collimators. The system is more successful than earlier multicollimator arrangements because each of the collimator/counters is virtually identical; this permits automatic addition of the intensities so that a single high resolution profile, up to X40 times as intense as on the original diffractometer, is obtained just as easily as on a single counter machine. A comparison is made with the other powder diffractometers, D1B and D2 at the ILL. (Auth.)

Public budgets for energy RD&D and the effects on energy intensity and pollution levels.

Science.gov (United States)

Balsalobre, Daniel; Álvarez, Agustín; Cantos, José María

2015-04-01

This study, based on the N-shaped cubic model of the environmental Kuznets curve, analyzes the evolution of per capita greenhouse gas emissions (GHGpc) using not just economic growth but also public budgets dedicated to energy-oriented research development and demonstration (RD&D) and energy intensity. The empirical evidence, obtained from an econometric model of fixed effects for 28 OECD countries during 1994-2010, suggests that energy innovations help reduce GHGpc levels and mitigate the negative impact of energy intensity on environmental quality. When countries develop active energy RD&D policies, they can reduce both the rates of energy intensity and the level of GHGpc emissions. This paper incorporates a moderating variable to the econometric model that emphasizes the effect that GDP has on energy intensity. It also adds a variable that reflects the difference between countries that have made a greater economic effort in energy RD&D, which in turn corrects the GHG emissions resulting from the energy intensity of each country.

State of the art of D ampersand D Instrumentation Technology: Alpha counting in the presence of high background

International Nuclear Information System (INIS)

Dickerman, C.E.

1995-08-01

Discrimination of alpha activity in the presence of a high radiation background has been identified as an area of concern to be studied for D ampersand D applications. Upon evaluating the range of alpha detection needs for D ampersand D operations, we have expanded this study to address the operational concern of greatly expediting alpha counting of rough surfaces and rubble. Note that the term, ''rough surfaces'' includes a wide range of practical cases, including contaminated equipment and work surfaces. We have developed provisional applications requirements for instrumentation of this type; and we also have generated the scope of a program of instrument evaluation and testing, with emphasis on practical implementation. In order to obtain the full operational benefit of alpha discrimination in the presence of strong beta-gamma radiation background, the detection system must be capable of some form of remote or semi-remote operation in order to reduce operator exposure. We have identified a highly promising technique, the long-range alpha detector (LRAD), for alpha discrimination in the presence of high radiation background. This technique operates upon the principle of transporting alphaionized air to an ionization detector. A transport time within a few seconds is adequate. Neither the provisional requirements nor the evaluation and testing scope were expressly tailored to force the selection of a LRAD technology, and they could be used as a basis for studies of other promising technologies. However, a technology that remotely detects alpha-ionized air (e. g., LRAD) is a natural fit to the key requirements of rejection of high background at the survey location and operator protection. Also, LRAD appears to be valuable for D ampersand D applications as a means of greatly expediting surface alpha-activity surveys that otherwise would require performing time-consuming scans over surfaces of interest with alpha detector probes, and even more labor-intensive surface

US Accelerator R&D Program Toward Intensity Frontier Machines

Energy Technology Data Exchange (ETDEWEB)

Shiltsev, Vladimir [Fermilab

2016-09-15

The 2014 P5 report indicated the accelerator-based neutrino and rare decay physics research as a centerpiece of the US domestic HEP program. Operation, upgrade and development of the accelerators for the near-term and longer-term particle physics program at the Intensity Frontier face formidable challenges. Here we discuss key elements of the accelerator physics and technology R&D program toward future multi-MW proton accelerators.

MAP3D: a media processor approach for high-end 3D graphics

Science.gov (United States)

Darsa, Lucia; Stadnicki, Steven; Basoglu, Chris

1999-12-01

Equator Technologies, Inc. has used a software-first approach to produce several programmable and advanced VLIW processor architectures that have the flexibility to run both traditional systems tasks and an array of media-rich applications. For example, Equator's MAP1000A is the world's fastest single-chip programmable signal and image processor targeted for digital consumer and office automation markets. The Equator MAP3D is a proposal for the architecture of the next generation of the Equator MAP family. The MAP3D is designed to achieve high-end 3D performance and a variety of customizable special effects by combining special graphics features with high performance floating-point and media processor architecture. As a programmable media processor, it offers the advantages of a completely configurable 3D pipeline--allowing developers to experiment with different algorithms and to tailor their pipeline to achieve the highest performance for a particular application. With the support of Equator's advanced C compiler and toolkit, MAP3D programs can be written in a high-level language. This allows the compiler to successfully find and exploit any parallelism in a programmer's code, thus decreasing the time to market of a given applications. The ability to run an operating system makes it possible to run concurrent applications in the MAP3D chip, such as video decoding while executing the 3D pipelines, so that integration of applications is easily achieved--using real-time decoded imagery for texturing 3D objects, for instance. This novel architecture enables an affordable, integrated solution for high performance 3D graphics.

Production of intense metallic ion beams in order of isotopic separations; Production de faisceaux intenses d'ions metalliques en vue de la separation des isotopes

Energy Technology Data Exchange (ETDEWEB)

Sarrouy, J L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1955-07-01

We describe an isotope separator with magnetic sector of 60 deg that permits, with a process of neutralization of the space charge, to use efficiently intense ion beams. The sources of realized ions provide ionic debits of 10 mA. This present work deals who to obtain intense ion beams (10 to 15 mA), different processes of ion currents measurement, as well as the study of the phenomenon of space charge neutralization. The second part of this memory will be on the survey and the adaptation on the source of various type of oven permitting to spray and to ionize metals directly. By order of increasing difficulty of vaporization, we reached the chromium. (M.B.) [French] 0n decrit un separateur d'isotope a secteur magnetique de 60 deg qui permet, grace a un procede de neutralisation de la charge d'espace, d'utiliser efficacement des faisceaux d'ions intenses. Les sources d'ions realisees fournissent des debits ioniques de 10 mA. Ce present travail porte sur l'obtention de faisceaux d'ions faisceaux d'ions intenses (10 a 15 mA), des differents procedes de mesures des courants d'ions, ainsi que l'etude du phenomene de neutralisation de charge d'espace. La deuxieme partie de ce memoire portera sur l'etude et l'adaptation sur la source de divers type de four permettant de vaporiser et d'ioniser directement les metaux. Par ordre de difficulte croissantes de vaporisations, nous avons atteint le chrome. (M.B.)

Segmentation of 3-D High-Frequency Ultrasound Images of Human Lymph Nodes Using Graph Cut With Energy Functional Adapted to Local Intensity Distribution.

Science.gov (United States)

Kuo, Jen-Wei; Mamou, Jonathan; Wang, Yao; Saegusa-Beecroft, Emi; Machi, Junji; Feleppa, Ernest J

2017-10-01

Previous studies by our group have shown that 3-D high-frequency quantitative ultrasound (QUS) methods have the potential to differentiate metastatic lymph nodes (LNs) from cancer-free LNs dissected from human cancer patients. To successfully perform these methods inside the LN parenchyma (LNP), an automatic segmentation method is highly desired to exclude the surrounding thin layer of fat from QUS processing and accurately correct for ultrasound attenuation. In high-frequency ultrasound images of LNs, the intensity distribution of LNP and fat varies spatially because of acoustic attenuation and focusing effects. Thus, the intensity contrast between two object regions (e.g., LNP and fat) is also spatially varying. In our previous work, nested graph cut (GC) demonstrated its ability to simultaneously segment LNP, fat, and the outer phosphate-buffered saline bath even when some boundaries are lost because of acoustic attenuation and focusing effects. This paper describes a novel approach called GC with locally adaptive energy to further deal with spatially varying distributions of LNP and fat caused by inhomogeneous acoustic attenuation. The proposed method achieved Dice similarity coefficients of 0.937±0.035 when compared with expert manual segmentation on a representative data set consisting of 115 3-D LN images obtained from colorectal cancer patients.

Validation for 2D/3D registration II: The comparison of intensity- and gradient-based merit functions using a new gold standard data set

International Nuclear Information System (INIS)

Gendrin, Christelle; Markelj, Primoz; Pawiro, Supriyanto Ardjo; Spoerk, Jakob; Bloch, Christoph; Weber, Christoph; Figl, Michael; Bergmann, Helmar; Birkfellner, Wolfgang; Likar, Bostjan; Pernus, Franjo

2011-01-01

Purpose: A new gold standard data set for validation of 2D/3D registration based on a porcine cadaver head with attached fiducial markers was presented in the first part of this article. The advantage of this new phantom is the large amount of soft tissue, which simulates realistic conditions for registration. This article tests the performance of intensity- and gradient-based algorithms for 2D/3D registration using the new phantom data set. Methods: Intensity-based methods with four merit functions, namely, cross correlation, rank correlation, correlation ratio, and mutual information (MI), and two gradient-based algorithms, the backprojection gradient-based (BGB) registration method and the reconstruction gradient-based (RGB) registration method, were compared. Four volumes consisting of CBCT with two fields of view, 64 slice multidetector CT, and magnetic resonance-T1 weighted images were registered to a pair of kV x-ray images and a pair of MV images. A standardized evaluation methodology was employed. Targets were evenly spread over the volumes and 250 starting positions of the 3D volumes with initial displacements of up to 25 mm from the gold standard position were calculated. After the registration, the displacement from the gold standard was retrieved and the root mean square (RMS), mean, and standard deviation mean target registration errors (mTREs) over 250 registrations were derived. Additionally, the following merit properties were computed: Accuracy, capture range, number of minima, risk of nonconvergence, and distinctiveness of optimum for better comparison of the robustness of each merit. Results: Among the merit functions used for the intensity-based method, MI reached the best accuracy with an RMS mTRE down to 1.30 mm. Furthermore, it was the only merit function that could accurately register the CT to the kV x rays with the presence of tissue deformation. As for the gradient-based methods, BGB and RGB methods achieved subvoxel accuracy (RMS m

D D Shivagan

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. D D Shivagan. Articles written in Bulletin of Materials Science. Volume 23 Issue 1 February 2000 pp 51-54 High T c superconductors. Electrochemical processing of high- Bi(Pb)–Sr–Ca–CuO thin films · N V Desai L A Ekal D D Shivagan S H Pawar · More Details Abstract ...

Integrated de SQUID magnetometer with high dV/dB

International Nuclear Information System (INIS)

Drung, D.; Cantor, R.; Peters, M.; Ryhanen, T.; Kochi, H.

1991-01-01

This paper presents a directly coupled dc SQUID magnetometer with very simple feedback electronics. The magnetometer has been integrated on a 7.2 x 7.2 mm 2 chip and fabricated using a four-level Nb/Si x N v /Nb process. Eight pick-up loops are connected in parallel to directly form the SQUID inductance of about 0.4 nH which leads to a high sensitivity B/Φ = 0.47 nT/Φ. An Additional Positive Feedback (APF) circuit on the magnetometer chip has been used to increase the gradient of the V-μ characteristic to dV/dΦ ≅ 300 μV/Φ 0 at the SQUID operating point. The resulting gradient of the transfer function of dV/dB ≅ 640 μV/nT makes it possible to directly read out the SQUID without helium temperature impedance matching circuits or flux modulation techniques

Grain refinement of AZ91D alloy by intensive melt shearing and its persistence after remelting and isothermal holding

Directory of Open Access Journals (Sweden)

Zuo Yubo

2013-01-01

Full Text Available Intensive melt shearing has a significant grain refining effect on some light alloys. However, the persistence of the grain refining effect during isothermal holding and remelting is still unclear, although it is very important for the practical application. In this study, intensive melt shearing was achieved in a twin-screw mechanism to investigate its grain refining effect on AZ91D magnesium alloy. The refinement mechanism was discussed and the persistence of grain refinement after remelting and isothermal holding was also studied. A Zeiss imaging system with polarized light was used for quantitative measurement of grain size. The results show that the intensive melt shearing has a significant grain refining effect on AZ91D magnesium alloy. With the application of intensive melt shearing, the grain size of AZ91D magnesium alloy can be reduced from 530 μm (for a typical as-cast microstructure to 170 μm, which is about 70% size reduction. The grain refinement achieved by the intensive melt shearing can be partially kept after isothermal holding and remelting. It is believed that the refinement effect was mainly due to the finer and well dispersed oxide particles formed by high intensive shearing. The smaller size of oxide particles and their slow motion velocity in the sheared melt could make important contributions to the remained grain refinement.

The combined effect of high-intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults.

Science.gov (United States)

Lithgow, Hannah Margaret; Florida-James, Geraint; Leggate, Melanie

2018-05-01

High-intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2DM). Independently, a low vitamin D status has also been linked to the prevalence of T2DM. The aim of this study was to investigate if there was a synergistic metabolic effect of HIIT and vitamin D supplementation on glycemic control. A total of 20 male and female participants (age, 34 ± 9 year; BMI, 31.4 ± 2.8 kg·m -2 ) completed 6 weeks HIIT, and were randomized to ingest 100 μg·day -1 of vitamin D 3 or placebo. Response to an oral glucose tolerance test (OGTT) was determined at baseline and at 72 h postintervention. Glucose tolerance was improved as a result of the HIIT intervention, shown through a reduction in glucose and insulin concentrations during the OGTT, accompanied by a decrease in glucose (829 ± 110 to 786 ± 139 mmol·h -1 ·L -1 ; P = 0.043) and insulin (8101 ± 4755-7024 ± 4489 mU·h -1 ·L -1 ; P = 0.049) area under the curve (AUC). Supplementation increased 25-hydroxyvitamin D 3 concentration by 120% to a sufficiency status (P effect of the intervention on insulin sensitivity (IS) indices: ISI M atsuda and HOMA-IR. Our findings demonstrate that HIIT improves glucose tolerance in nondiabetic overweight and obese adults; however vitamin D 3 supplementation did not proffer any additional positive effects on the measured indices of metabolic health. © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

Development of Portable Pulsed Neutron Generators Utilizing a D-T or D-D Fusion Reaction

International Nuclear Information System (INIS)

Nishimura, Kazuya; Miake, Yoshinobu; Kato, Michio; Rintsu, Yukou

2001-01-01

Prototypes of sealed neutron tubes in a D-T or D-D fusion reaction for logging while drilling (LWD) were developed; then operational tests were performed to check their functional properties. One of the prototypes passed most of the specified conditions for using LWD. Further studies were needed to put a sealed neutron tube into practical use. For applications to other fields, such as an in situ calibration source for neutron detector efficiencies and an in situ calibration source for fusion systems, a sealed neutron tube is needed to have higher-intensity neutron output and a long life. Thus, the performance of the ion source used in the neutron tube is improved to obtain high gas utilization efficiencies or low-pressure operation with high ionization efficiencies. The characteristics of the new ion sources used in the foregoing sealed neutron tube are discussed in terms of preliminary tests. The aforementioned performances are obtained

[Vitamin D deficiency in children admitted to the paediatric intensive care unit].

Science.gov (United States)

Bustos B, Raúl; Rodríguez-Nuñez, Iván; Peña Zavala, Rubén; Soto Germani, Gonzalo

Vitamin D is essential for bone health, as well as for cardiovascular and immune function. In critically ill adults vitamin D deficiency (VDD) is common, and is associated with sepsis and higher critical illness severity. To establish the prevalence of VDD and its association with clinically relevant outcomes in children admitted to a Paediatric Intensive Care Unit (PICU) in Concepcion, Chile. Prospective observational cohort study in 90 consecutive children admitted to the PICU in a university general hospital. Blood was collected on admission to PICU and analysed for 25-OH-D levels. Severity of illness and vasopressor use were assessed using PRISM, PELOD, and vasoactive-inotropic score (VIS) score. VDD was defined as a serum 25-OH-D level40ml/kg in the first 24h of admission (RR 1.5; 95%CI: 1.1-2.1, P<.05). In this study, VDD at PICU admission was prevalent in critically ill children and was associated with adverse clinical outcomes. Further studies are needed to assess the potential benefit of optimizing vitamin D status in the PICU. Copyright © 2016 Sociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

Fracto-mechanoluminescent light emission of EuD4TEA-PDMS composites subjected to high strain-rate compressive loading

Science.gov (United States)

Ryu, Donghyeon; Castaño, Nicolas; Bhakta, Raj; Kimberley, Jamie

2017-08-01

The objective of this study is to understand light emission characteristics of fracto-mechanoluminescent (FML) europium tetrakis(dibenzoylmethide)-triethylammonium (EuD4TEA) crystals under high strain-rate compressive loading. As a sensing material that can play a pivotal role for the self-powered impact sensor technology, it is important to understand transformative light emission characteristics of the FML EuD4TEA crystals under high strain-rate compressive loading. First, EuD4TEA crystals were synthesized and embedded into polydimethylsiloxane (PDMS) elastomer to fabricate EuD4TEA-PDMS composite test specimens. Second, the prepared EuD4TEA-PDMS composites were tested using the modified Kolsky bar setup equipped with a high-speed camera. Third, FML light emission was captured to yield 12 bit grayscale video footage, which was processed to quantify the FML light emission. Finally, quantitative parameters were generated by taking into account pixel values and population of pixels of the 12 bit grayscale images to represent FML light intensity. The FML light intensity was correlated with high strain-rate compressive strain and strain rate to understand the FML light emission characteristics under high strain-rate compressive loading that can result from impact occurrences.

3D MR cisternography to identify distal dural rings. Comparison of 3D-CISS and 3D-SPACE sequences

International Nuclear Information System (INIS)

Watanabe, Yoshiyuki; Makidono, Akari; Nakamura, Miho; Saida, Yukihisa

2011-01-01

The distal dural ring (DDR) is an anatomical landmark used to distinguish intra- and extradural aneurysms. We investigated identification of the DDR using 2 three-dimensional (3D) magnetic resonance (MR) cisternography sequences-3D constructive interference in steady state (CISS) and 3D sampling perfection with application optimized contrasts using different flip angle evolutions (SPACE)-at 3.0 tesla. Ten healthy adult volunteers underwent imaging with 3D-CISS, 3D-SPACE, and time-of-flight (TOF) MR angiography (TOF-MRA) sequences at 3.0T. We analyzed DDR identification and internal carotid artery (ICA) signal intensity and classified the shape of the carotid cave. We identified the DDR using both 3D-SPACE and 3D-CISS, with no significant difference between the sequences. Visualization of the outline of the ICA in the cavernous sinus (CS) was significantly clearer with 3D-SPACE than 3D-CISS. In the CS and petrous portions, signal intensity was lower with 3D-SPACE, and the flow void was poor with 3D-CISS in some subjects. We identified the DDR with both 3D-SPACE and 3D-CISS, but the superior contrast of the ICA in the CS using 3D-SPACE suggests the superiority of this sequence for evaluating the DDR. (author)

FERMILAB ACCELERATOR R&D PROGRAM TOWARDS INTENSITY FRONTIER ACCELERATORS : STATUS AND PROGRESS

Energy Technology Data Exchange (ETDEWEB)

Shiltsev, Vladimir [Fermilab

2016-11-15

The 2014 P5 report indicated the accelerator-based neutrino and rare decay physics research as a centrepiece of the US domestic HEP program at Fermilab. Operation, upgrade and development of the accelerators for the near- term and longer-term particle physics program at the Intensity Frontier face formidable challenges. Here we discuss key elements of the accelerator physics and technology R&D program toward future multi-MW proton accelerators and present its status and progress. INTENSITY FRONTIER ACCELERATORS

Portable high-intensity focused ultrasound system with 3D electronic steering, real-time cavitation monitoring, and 3D image reconstruction algorithms: a preclinical study in pigs

International Nuclear Information System (INIS)

Choi, Jin Woo; Lee, Jae Young; Hwang, Eui Jin; Hwang, In Pyeong; Woo, Sung Min; Lee, Chang Joo; Park, Eun Joo; Choi, Byung Ihn

2014-01-01

The aim of this study was to evaluate the safety and accuracy of a new portable ultrasonography-guided high-intensity focused ultrasound (USg-HIFU) system with a 3-dimensional (3D) electronic steering transducer, a simultaneous ablation and imaging module, real-time cavitation monitoring, and 3D image reconstruction algorithms. To address the accuracy of the transducer, hydrophones in a water chamber were used to assess the generation of sonic fields. An animal study was also performed in five pigs by ablating in vivo thighs by single-point sonication (n=10) or volume sonication (n=10) and ex vivo kidneys by single-point sonication (n=10). Histological and statistical analyses were performed. In the hydrophone study, peak voltages were detected within 1.0 mm from the targets on the y- and z-axes and within 2.0-mm intervals along the x-axis (z-axis, direction of ultrasound propagation; y- and x-axes, perpendicular to the direction of ultrasound propagation). Twenty-nine of 30 HIFU sessions successfully created ablations at the target. The in vivo porcine thigh study showed only a small discrepancy (width, 0.5-1.1 mm; length, 3.0 mm) between the planning ultrasonograms and the pathological specimens. Inordinate thermal damage was not observed in the adjacent tissues or sonic pathways in the in vivo thigh and ex vivo kidney studies. Our study suggests that this new USg-HIFU system may be a safe and accurate technique for ablating soft tissues and encapsulated organs.

Portable high-intensity focused ultrasound system with 3D electronic steering, real-time cavitation monitoring, and 3D image reconstruction algorithms: a preclinical study in pigs

Energy Technology Data Exchange (ETDEWEB)

Choi, Jin Woo; Lee, Jae Young; Hwang, Eui Jin; Hwang, In Pyeong; Woo, Sung Min; Lee, Chang Joo; Park, Eun Joo; Choi, Byung Ihn [Dept. of Radiology and Institute of Radiation Medicine, Seoul National University Hospital, Seoul (Korea, Republic of)

2014-10-15

The aim of this study was to evaluate the safety and accuracy of a new portable ultrasonography-guided high-intensity focused ultrasound (USg-HIFU) system with a 3-dimensional (3D) electronic steering transducer, a simultaneous ablation and imaging module, real-time cavitation monitoring, and 3D image reconstruction algorithms. To address the accuracy of the transducer, hydrophones in a water chamber were used to assess the generation of sonic fields. An animal study was also performed in five pigs by ablating in vivo thighs by single-point sonication (n=10) or volume sonication (n=10) and ex vivo kidneys by single-point sonication (n=10). Histological and statistical analyses were performed. In the hydrophone study, peak voltages were detected within 1.0 mm from the targets on the y- and z-axes and within 2.0-mm intervals along the x-axis (z-axis, direction of ultrasound propagation; y- and x-axes, perpendicular to the direction of ultrasound propagation). Twenty-nine of 30 HIFU sessions successfully created ablations at the target. The in vivo porcine thigh study showed only a small discrepancy (width, 0.5-1.1 mm; length, 3.0 mm) between the planning ultrasonograms and the pathological specimens. Inordinate thermal damage was not observed in the adjacent tissues or sonic pathways in the in vivo thigh and ex vivo kidney studies. Our study suggests that this new USg-HIFU system may be a safe and accurate technique for ablating soft tissues and encapsulated organs.

Domestic R&D and Offshoring

DEFF Research Database (Denmark)

Junge, Martin; Sørensen, Anders

2017-01-01

survey and register data. No evidence is found for a lower probability of own R&D after offshoring takes place compared to before. Moreover, offshoring does not lead to lower R&D intensity in general. However, firms that offshore R&D activity have larger R&D intensity after offshoring has taken place...

Tritium solid targets for intense D-T neutron production and its related problems

International Nuclear Information System (INIS)

Sumita, Kenji

1988-01-01

This review paper is divided into three parts. Firstly, to attain an intense neutron production rate, the construction of a design with a higher tritium-containing surface and an effective cooling system like a rotating target device are discussed. The maximum attainable intensity based on tritium solid targets shall be estimated regarding planning for future D-T sources. Secondly, on the way to carry out some experiments, an absolute intensity calibration and an angular dependent neutron energy spectrum of the neutron source are essential parameters to analyse the results of the experiments. Sometimes the space dependent neutron spectrum is required as well as the space dependent neutron flux near the targets and irradiation samples. The measurement methods and their examples are reviewed for tritium solid targets. The third part is devoted to discuss the protection to tritium contamination problems due to unavoidable release of tritium gas from targets. Performance and effectiveness of tritium collection systems for intense D-T neutron sources shall be discussed in some examples. Tritium contamination incidents due to the faulted film powder of target surface are also reported in some real incident cases. (author). Abstract only

Study of deuteron break-up at low energies in the reactions D(d,pn)d and D(d,dn)p

International Nuclear Information System (INIS)

Cocu, Francis; Ambrosino, Georges; Guerreau, Daniel.

1977-06-01

Quasi-free scattering in the reactions d+D=n+p+d has been studied at incident energies between 7 and 12 MeV by steps of 1 MeV. In a kinematically complete experiment, the cross sections were measured for the coincidences (p,n) and for the coincidences (d,n). The energy of the charged particle was also enregistered. The detector of the charged particles was put at an angle thetasub(p)=thetasub(d)=19 0 5 counted from the incident axis, the detector of neutrons at thetasub(n)=-30 0 . The geometry was coplanar. Pure gaseous target gives an excellent signal/back-ground ratio. The measure of the time-of-flight of the neutron allows indirectly the discrimination of the nature of the detected charged particle. Absolute cross sections are compared with the results of the complete Born approximation. The nucleon-nucleon potential is spin-dependant. The shape of the measured (d,n) spectra is fairly well reproduced but not its intensity. The (p,n) spectra is not so well reproduced but the distortion diminishes on increasing the incident energy [fr

Relative Match Intensities at High Altitude in Highly-Trained Young Soccer Players (ISA3600).

Science.gov (United States)

Buchheit, Martin; Hammond, Kristal; Bourdon, Pitre C; Simpson, Ben M; Garvican-Lewis, Laura A; Schmidt, Walter F; Gore, Christopher J; Aughey, Robert J

2015-03-01

To compare relative match intensities of sea-level versus high-altitude native soccer players during a 2-week camp at 3600 m, data from 7 sea-level (Australian U17 National team, AUS) and 6 high-altitude (a Bolivian U18 team, BOL) native soccer players were analysed. Two matches were played at sea-level and three at 3600 m on Days 1, 6 and 13. The Yo-Yo Intermittent recovery test (vYo-YoIR1) was performed at sea-level, and on Days 3 and 10. Match activity profiles were measured via 10-Hz GPS. Distance covered >14.4 km.h(-1) (D>14.4 km·h(-1)) and >80% of vYo-YoIR1 (D>80%vYo-YoIR1) were examined. Upon arrival at altitude, there was a greater decrement in vYo-YoIR1 (Cohen's d +1.0, 90%CL ± 0.8) and D>14.4 km·h(-1) (+0.5 ± 0.8) in AUS. D>14.4 km.h(-1) was similarly reduced relative to vYo-YoIR1 in both groups, so that D>80%vYo-YoIR1 remained similarly unchanged (-0.1 ± 0.8). Throughout the altitude sojourn, vYo-YoIR1 and D>14.4 km·h(-1) increased in parallel in AUS, so that D>80%vYo-YoIR1 remained stable in AUS (+6.0%/match, 90%CL ± 6.7); conversely D>80%vYo-YoIR1 decreased largely in BOL (-12.2%/match ± 6.2). In sea-level natives competing at high-altitude, changes in match running performance likely follow those in high-intensity running performance. Bolivian data confirm that increases in 'fitness' do not necessarily translate into greater match running performance, but rather in reduced relative exercise intensity. Key pointsWhen playing at high-altitude, players may alter their activities during matches in relation to their transient maximal physical capacities, possibly to maintain a 'tolerable' relative exercise intensity.While there is no doubt that running performance per se in not the main determinant of match outcomes (Carling, 2013), fitness levels influence relative match intensity (Buchheit et al., 2012, Mendez-Villanueva et al., 2013), which in-turn may impact on decision making and skill performance (Rampinini et al., 2008).In the context of

Detection of an intense polychromatic gamma beam modulated at 3000 MHz; Detection d'un faisceau intense de gammas polychromatiques module a 3000 MHz

Energy Technology Data Exchange (ETDEWEB)

Beil, H; Veyssiere, A; Daujat, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1968-07-01

This paper presents two methods of detection of a {gamma} beam modulated at very high frequencies. The intense modulated beam is created by means of Bremsstrahlung in a gold-target, the latter having been placed in the emerging electron beam of the Linac at Saclay. A tentative interpretation of the physical phenomena involved in the detection processes is also given. The empirical data agree reasonably well with numerical evaluations based on well established theoretical concepts concerning these phenomena. (authors) [French] Cet article presente deux facons de detecter un faisceau de {gamma} module a haute frequence. Le faisceau intense de {gamma} est cree par l'impact d'electrons (acceleres dans un accelerateur lineaire) sur une cible en or. Une tentative d'interpretation des phenomenes physiques mis en cause dans le processus de detection est donnee et les valeurs experimentales trouvees s'accordent raisonnablement bien avec les valeurs calculees a partir des considerations theoriques des phenomenes. (auteurs)

An intense plane-beam ion source (1963); Source d'ions intense a faisceau plan (1963)

Energy Technology Data Exchange (ETDEWEB)

Deicas, R; Valckx, F P.O. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1963-07-01

Experiments are described carried out on the cross-section of a Penning type ion source which is a prototype of the annular ion source intended for the M.M.I.I. device at the Fontenay-aux-Roses Nuclear Research Centre. It is shown that the existence or absence of a very strong concentration depends in particular on the magnetic geometry. With a suitable magnetic and electrical geometry it is possible to concentrate the discharge towards the slit and thus to increase considerably the electrical yield and the gas yield. In pulsed conditions, the current derived from this source can exceed 100 mA with a slit 20 cm long and 0.2 mm wide. The gas yield can attain 20 per cent. The main characteristics of the discharge and of the beam are examined. (authors) [French] On decrit les experiences faites sur une section droite d'une source d'ions type Penning, qui est un prototype pour une source d'ions annulaire, destine au dispositif M.M.I.I. au Centre d'Etudes Nucleaires de Fontenay-aux-Roses. On montre que l'existence ou non d'un regime intense depend surtout de la geometrie magnetique. Avec une geometrie magnetique et electrique convenables on peut concentrer la decharge vers les levres et ainsi augmenter considerablement le rendement electrique et le rendement en gaz. En regime pulse le courant extrait de cette source peut depasser 100 mA avec une fente de 20 cm de long et 0. 2 mm de largeur. Le rendement en gaz peut atteindre 20 pour cent. On etudie les principales caracteristiques de la decharge et du faisceau. (auteurs)

D-dimer to guide the intensity of anticoagulation in Chinese patients after mechanical heart valve replacement: a randomized controlled trial.

Science.gov (United States)

Zhang, L; Zheng, X; Long, Y; Wu, M; Chen, Y; Yang, J; Liu, Z; Zhang, Z

2017-10-01

Essentials Low anticoagulation intensity reduces bleeding but increases thrombosis during warfarin therapy. Elevated D-dimer level is associated with increased thrombosis events. D-dimer can be used to find potential thrombosis in those receiving low intensity therapy. D-dimer-guided therapy may be the optimal strategy for those with mechanical heart valve replacement. Background Controversies remain regarding the optimal anticoagulation intensity for Chinese patients after mechanical heart valve replacement despite guidelines having recommended a standard anticoagulation intensity. Objectives To investigate whether D-dimer could be used to determine the optimal anticoagulation intensity in Chinese patients after mechanical heart valve replacement. Patients/Methods This was a prospective, randomized controlled clinical study. A total of 748 patients following mechanical heart valve replacement in Wuhan Asia Heart Hospital were randomized to three groups at a ratio of 1 : 1 : 1. Patients in two control groups received warfarin therapy based on constant standard intensity (international normalized ratio [INR], 2.5-3.5; n = 250) and low intensity (INR, 1.8-2.6; n = 248), respectively. In the experimental group (n = 250), warfarin therapy was initiated at low intensity, then those with elevated D-dimer levels were adjusted to standard intensity. All patients were followed-up for 24 months until the occurrence of endpoints, including bleeding events, thrombotic events and all-cause mortality. Results A total of 718 patients were included in the analysis. Fifty-three events occurred during follow-up. There was less hemorrhage (3/240 vs. 16/241; hazard ratio [HR], 0.18; 95% confidence interval [CI], 0.07-0.45) and all-cause mortality (4/240 vs. 12/241; HR, 0.33; 95% CI, 0.12-0.87) observed in the D-dimer-guided group than in the standard-intensity group. A lower incidence of thrombotic events was also observed in the D-dimer-guided group when compared with the

D-D tokamak reactor assessment

International Nuclear Information System (INIS)

Baxter, D.C.; Dabiri, A.E.

1983-01-01

A quantitative comparison of the physics and technology requirements, and the cost and safety performance of a d-d tokamak relative to a d-t tokamak has been performed. The first wall/blanket and energy recovery cycle for the d-d tokamak is simpler, and has a higher efficiency than the d-t tokamak. In most other technology areas (such as magnets, RF, vacuum, etc.) d-d requirements are more severe and the systems are more complex, expensive and may involve higher technical risk than d-t tokamak systems. Tritium technology for processing the plasma exhaust, and tritium refueling technology are required for d-d reactors, but no tritium containment around the blanket or heat transport system is needed. Cost studies show that for high plasma beta and high magnetic field the cost of electricity from d-d and d-t tokamaks is comparable. Safety analysis shows less radioactivity in a d-d reactor but larger amounts of stored energy and thus higher potential for energy release. Consequences of all postulated d-d accidents are significantly smaller than those from d-t reactor tritium releases

Data Assimilation of Lightning using 1D+3D/4D WRF Var Assimilation Schemes with Non-Linear Observation Operators

Science.gov (United States)

Navon, M. I.; Stefanescu, R.; Fuelberg, H. E.; Marchand, M.

2012-12-01

NASA's launch of the GOES-R Lightning Mapper (GLM) in 2015 will provide continuous, full disc, high resolution total lightning (IC + CG) data. The data will be available at a horizontal resolution of approximately 9 km. Compared to other types of data, the assimilation of lightning data into operational numerical models has received relatively little attention. Previous efforts of lightning assimilation mostly have employed nudging. This paper will describe the implementation of 1D+3D/4D Var assimilation schemes of existing ground-based WTLN (Worldwide Total Lightning Network) lightning observations using non-linear observation operators in the incremental WRFDA system. To mimic the expected output of GLM, the WTLN data were used to generate lightning super-observations characterized by flash rates/81 km2/20 min. A major difficulty associated with variational approaches is the complexity of the observation operator that defines the model equivalent of lightning. We use Convective Available Potential Energy (CAPE) as a proxy between lightning data and model variables. This operator is highly nonlinear. Marecal and Mahfouf (2003) have shown that nonlinearities can prevent direct assimilation of rainfall rates in the ECMWF 4D-VAR (using the incremental formulation proposed by Courtier et al. (1994)) from being successful. Using data from the 2011 Tuscaloosa, AL tornado outbreak, we have proved that the direct assimilation of lightning data into the WRF 3D/4D - Var systems is limited due to this incremental approach. Severe threshold limits must be imposed on the innovation vectors to obtain an improved analysis. We have implemented 1D+3D/4D Var schemes to assimilate lightning observations into the WRF model. Their use avoids innovation vector constrains from preventing the inclusion of a greater number of lightning observations Their use also minimizes the problem that nonlinearities in the moist convective scheme can introduce discontinuities in the cost function

Monoplane 3D-2D registration of cerebral angiograms based on multi-objective stratified optimization

Science.gov (United States)

Aksoy, T.; Špiclin, Ž.; Pernuš, F.; Unal, G.

2017-12-01

Registration of 3D pre-interventional to 2D intra-interventional medical images has an increasingly important role in surgical planning, navigation and treatment, because it enables the physician to co-locate depth information given by pre-interventional 3D images with the live information in intra-interventional 2D images such as x-ray. Most tasks during image-guided interventions are carried out under a monoplane x-ray, which is a highly ill-posed problem for state-of-the-art 3D to 2D registration methods. To address the problem of rigid 3D-2D monoplane registration we propose a novel multi-objective stratified parameter optimization, wherein a small set of high-magnitude intensity gradients are matched between the 3D and 2D images. The stratified parameter optimization matches rotation templates to depth templates, first sampled from projected 3D gradients and second from the 2D image gradients, so as to recover 3D rigid-body rotations and out-of-plane translation. The objective for matching was the gradient magnitude correlation coefficient, which is invariant to in-plane translation. The in-plane translations are then found by locating the maximum of the gradient phase correlation between the best matching pair of rotation and depth templates. On twenty pairs of 3D and 2D images of ten patients undergoing cerebral endovascular image-guided intervention the 3D to monoplane 2D registration experiments were setup with a rather high range of initial mean target registration error from 0 to 100 mm. The proposed method effectively reduced the registration error to below 2 mm, which was further refined by a fast iterative method and resulted in a high final registration accuracy (0.40 mm) and high success rate (> 96%). Taking into account a fast execution time below 10 s, the observed performance of the proposed method shows a high potential for application into clinical image-guidance systems.

Nonlinear interaction of an intense radio wave with ionospheric D/E layer plasma

Science.gov (United States)

Sodha, Mahendra Singh; Agarwal, Sujeet Kumar

2018-05-01

This paper considers the nonlinear interaction of an intense electromagnetic wave with the D/E layer plasma in the ionosphere. A simultaneous solution of the electromagnetic wave equation and the equations describing the kinetics of D/E layer plasma is obtained; the phenomenon of ohmic heating of electrons by the electric field of the wave causes enhanced collision frequency and ionization of neutral species. Electron temperature dependent recombination of electrons with ions, electron attachment to O 2 molecules, and detachment of electrons from O2 - ions has also been taken into account. The dependence of the plasma parameters on the square of the electric vector of the wave E0 2 has been evaluated for three ionospheric heights (viz., 90, 100, and 110 km) corresponding to the mid-latitude mid-day ionosphere and discussed; these results are used to investigate the horizontal propagation of an intense radio wave at these heights.

Analysis of scalability of high-performance 3D image processing platform for virtual colonoscopy.

Science.gov (United States)

Yoshida, Hiroyuki; Wu, Yin; Cai, Wenli

2014-03-19

One of the key challenges in three-dimensional (3D) medical imaging is to enable the fast turn-around time, which is often required for interactive or real-time response. This inevitably requires not only high computational power but also high memory bandwidth due to the massive amount of data that need to be processed. For this purpose, we previously developed a software platform for high-performance 3D medical image processing, called HPC 3D-MIP platform, which employs increasingly available and affordable commodity computing systems such as the multicore, cluster, and cloud computing systems. To achieve scalable high-performance computing, the platform employed size-adaptive, distributable block volumes as a core data structure for efficient parallelization of a wide range of 3D-MIP algorithms, supported task scheduling for efficient load distribution and balancing, and consisted of a layered parallel software libraries that allow image processing applications to share the common functionalities. We evaluated the performance of the HPC 3D-MIP platform by applying it to computationally intensive processes in virtual colonoscopy. Experimental results showed a 12-fold performance improvement on a workstation with 12-core CPUs over the original sequential implementation of the processes, indicating the efficiency of the platform. Analysis of performance scalability based on the Amdahl's law for symmetric multicore chips showed the potential of a high performance scalability of the HPC 3D-MIP platform when a larger number of cores is available.

A Comparison of Helical Intensity-Modulated Radiotherapy, Intensity-Modulated Radiotherapy, and 3D-Conformal Radiation Therapy for Pancreatic Cancer

International Nuclear Information System (INIS)

Poppe, Matthew M.; Narra, Venkat; Yue, Ning J.; Zhou Jinghao; Nelson, Carl; Jabbour, Salma K.

2011-01-01

We assessed dosimetric differences in pancreatic cancer radiotherapy via helical intensity-modulated radiotherapy (HIMRT), linac-based IMRT, and 3D-conformal radiation therapy (3D-CRT) with regard to successful plan acceptance and dose to critical organs. Dosimetric analysis was performed in 16 pancreatic cases that were planned to 54 Gy; both post-pancreaticoduodenectomy (n = 8) and unresected (n = 8) cases were compared. Without volume modification, plans met constraints 75% of the time with HIMRT and IMRT and 13% with 3D-CRT. There was no statistically significantly improvement with HIMRT over conventional IMRT in reducing liver V35, stomach V45, or bowel V45. HIMRT offers improved planning target volume (PTV) dose homogeneity compared with IMRT, averaging a lower maximum dose and higher volume receiving the prescription dose (D100). HIMRT showed an increased mean dose over IMRT to bowel and liver. Both HIMRT and IMRT offer a statistically significant improvement over 3D-CRT in lowering dose to liver, stomach, and bowel. The results were similar for both unresected and resected patients. In pancreatic cancer, HIMRT offers improved dose homogeneity over conventional IMRT and several significant benefits to 3D-CRT. Factors to consider before incorporating IMRT into pancreatic cancer therapy are respiratory motion, dose inhomogeneity, and mean dose.

High-Dose Vitamin D3 during Tuberculosis Treatment in Mongolia. A Randomized Controlled Trial.

Science.gov (United States)

Ganmaa, Davaasambuu; Munkhzul, Baatar; Fawzi, Wafaie; Spiegelman, Donna; Willett, Walter C; Bayasgalan, Purev; Baasansuren, Erkhembayar; Buyankhishig, Burneebaatar; Oyun-Erdene, Sereeter; Jolliffe, David A; Xenakis, Theodoros; Bromage, Sabri; Bloom, Barry R; Martineau, Adrian R

2017-09-01

Existing trials of adjunctive vitamin D in the treatment of pulmonary tuberculosis (PTB) are variously limited by small sample sizes, inadequate dosing regimens, and high baseline vitamin D status among participants. Comprehensive analyses of the effects of genetic variation in the vitamin D pathway on response to vitamin D supplementation are lacking. To determine the effect of high-dose vitamin D 3 on response to antimicrobial therapy for PTB and to evaluate the influence of single-nucleotide polymorphisms (SNPs) in vitamin D pathway genes on response to adjunctive vitamin D 3 . We conducted a clinical trial in 390 adults with PTB in Ulaanbaatar, Mongolia, who were randomized to receive four biweekly doses of 3.5 mg (140,000 IU) vitamin D 3 (n = 190) or placebo (n = 200) during intensive-phase antituberculosis treatment. The intervention elevated 8-week serum 25-hydroxyvitamin D concentrations (154.5 nmol/L vs. 15.2 nmol/L in active vs. placebo arms, respectively; 95% confidence interval for difference, 125.9-154.7 nmol/L; P vitamin D 3 accelerated sputum culture conversion in patients with one or more minor alleles for SNPs in genes encoding the vitamin D receptor (rs4334089, rs11568820) and 25-hydroxyvitamin D 1α-hydroxylase (CYP27B1: rs4646536) (adjusted hazard ratio ≥ 1.47; P for interaction ≤ 0.02). Vitamin D 3 did not influence time to sputum culture conversion in the study population overall. Effects of the intervention were modified by SNPs in VDR and CYP27B1. Clinical trial registered with www.clinicaltrials.gov (NCT01657656).

Assessment of the signal intensity distribution pattern within the unruptured cerebral aneurysms using color-coded 3D MR angiography

International Nuclear Information System (INIS)

Satoh, Toru; Omi, Megumi; Ohsako, Chika

2005-01-01

To evaluate the interaction between the MR signal intensity distribution pattern and bleb formation/deformation of the aneurysmal dome, fifty cases of the unruptured cerebral aneurysms were investigated with the color-coded 3D MR angiography. Patterns were categorized into central-type, neck-type and peripheral-type according to the distribution of MR signals with low-, moderate- and high signal intensity areas. Imaging analysis revealed the significant relationship (P<0.02) of the peripheral-type aneurysms to the bleb formation and deformation of the dome, compared with those of central- and neck-type. Additionally, peripheral-type signal intensity distribution pattern was shown with aneurysms harboring relatively large dome size and lateral-type growth including internal carotid aneurysms. Prospective analysis of intraaneurysmal flow pattern with the color-coded 3D MR angiography may provide patient-specific analysis of intraaneurysmal flow status in relation to the morphological change of the corresponding aneurysmal dome in the management of unruptured cerebral aneurysms. (author)

Anal wall sparing effect of an endorectal balloon in 3D conformal and intensity-modulated prostate radiotherapy.

NARCIS (Netherlands)

Smeenk, R.J.; Lin, E.N.J.T. van; Kollenburg, P. van; Kunze-Busch, M.C.; Kaanders, J.H.A.M.

2009-01-01

BACKGROUND AND PURPOSE: To investigate the anal wall (Awall) sparing effect of an endorectal balloon (ERB) in 3D conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for prostate cancer. MATERIALS AND METHODS: In 24 patients with localized prostate carcinoma, two planning

High-Precision Phenotyping of Grape Bunch Architecture Using Fast 3D Sensor and Automation.

Science.gov (United States)

Rist, Florian; Herzog, Katja; Mack, Jenny; Richter, Robert; Steinhage, Volker; Töpfer, Reinhard

2018-03-02

Wine growers prefer cultivars with looser bunch architecture because of the decreased risk for bunch rot. As a consequence, grapevine breeders have to select seedlings and new cultivars with regard to appropriate bunch traits. Bunch architecture is a mosaic of different single traits which makes phenotyping labor-intensive and time-consuming. In the present study, a fast and high-precision phenotyping pipeline was developed. The optical sensor Artec Spider 3D scanner (Artec 3D, L-1466, Luxembourg) was used to generate dense 3D point clouds of grapevine bunches under lab conditions and an automated analysis software called 3D-Bunch-Tool was developed to extract different single 3D bunch traits, i.e., the number of berries, berry diameter, single berry volume, total volume of berries, convex hull volume of grapes, bunch width and bunch length. The method was validated on whole bunches of different grapevine cultivars and phenotypic variable breeding material. Reliable phenotypic data were obtained which show high significant correlations (up to r² = 0.95 for berry number) compared to ground truth data. Moreover, it was shown that the Artec Spider can be used directly in the field where achieved data show comparable precision with regard to the lab application. This non-invasive and non-contact field application facilitates the first high-precision phenotyping pipeline based on 3D bunch traits in large plant sets.

Thermally Stable Cellulose Nanocrystals toward High-Performance 2D and 3D Nanostructures.

Science.gov (United States)

Jia, Chao; Bian, Huiyang; Gao, Tingting; Jiang, Feng; Kierzewski, Iain Michael; Wang, Yilin; Yao, Yonggang; Chen, Liheng; Shao, Ziqiang; Zhu, J Y; Hu, Liangbing

2017-08-30

Cellulose nanomaterials have attracted much attention in a broad range of fields such as flexible electronics, tissue engineering, and 3D printing for their excellent mechanical strength and intriguing optical properties. Economic, sustainable, and eco-friendly production of cellulose nanomaterials with high thermal stability, however, remains a tremendous challenge. Here versatile cellulose nanocrystals (DM-OA-CNCs) are prepared through fully recyclable oxalic acid (OA) hydrolysis along with disk-milling (DM) pretreatment of bleached kraft eucalyptus pulp. Compared with the commonly used cellulose nanocrystals from sulfuric acid hydrolysis, DM-OA-CNCs show several advantages including large aspect ratio, carboxylated surface, and excellent thermal stability along with high yield. We also successfully demonstrate the fabrication of high-performance films and 3D-printed patterns using DM-OA-CNCs. The high-performance films with high transparency, ultralow haze, and excellent thermal stability have the great potential for applications in flexible electronic devices. The 3D-printed patterns with porous structures can be potentially applied in the field of tissue engineering as scaffolds.

Analyzing 3D xylem networks in Vitis vinifera using High Resolution Computed Tomography (HRCT)

Science.gov (United States)

Recent developments in High Resolution Computed Tomography (HRCT) have made it possible to visualize three dimensional (3D) xylem networks without time consuming, labor intensive physical sectioning. Here we describe a new method to visualize complex vessel networks in plants and produce a quantitat...

Aqueous stress-corrosion cracking of high-toughness D6AC steel

Science.gov (United States)

Gilbreath, W. P.; Adamson, M. J.

1976-01-01

The crack growth behavior of D6AC steel as a function of stress intensity, stress and corrosion history, and test technique, under sustained load in filtered natural seawater, 3.3 per cent sodium chloride solution, and distilled water, was investigated. Reported investigations of D6AC were considered in terms of the present study with emphasis on thermal treatment, specimen configuration, fracture toughness, crack-growth rates, initiation period, and threshold. Both threshold and growth kinetics were found to be relatively insensitive to these test parameters. The apparent incubation period was dependent on technique, both detection sensitivity and precracking stress intensity level.

Highly-stretchable 3D-architected Mechanical Metamaterials

Science.gov (United States)

Jiang, Yanhui; Wang, Qiming

2016-09-01

Soft materials featuring both 3D free-form architectures and high stretchability are highly desirable for a number of engineering applications ranging from cushion modulators, soft robots to stretchable electronics; however, both the manufacturing and fundamental mechanics are largely elusive. Here, we overcome the manufacturing difficulties and report a class of mechanical metamaterials that not only features 3D free-form lattice architectures but also poses ultrahigh reversible stretchability (strain > 414%), 4 times higher than that of the existing counterparts with the similar complexity of 3D architectures. The microarchitected metamaterials, made of highly stretchable elastomers, are realized through an additive manufacturing technique, projection microstereolithography, and its postprocessing. With the fabricated metamaterials, we reveal their exotic mechanical behaviors: Under large-strain tension, their moduli follow a linear scaling relationship with their densities regardless of architecture types, in sharp contrast to the architecture-dependent modulus power-law of the existing engineering materials; under large-strain compression, they present tunable negative-stiffness that enables ultrahigh energy absorption efficiencies. To harness their extraordinary stretchability and microstructures, we demonstrate that the metamaterials open a number of application avenues in lightweight and flexible structure connectors, ultraefficient dampers, 3D meshed rehabilitation structures and stretchable electronics with designed 3D anisotropic conductivity.

3D Printing of Highly Stretchable, Shape-Memory, and Self-Healing Elastomer toward Novel 4D Printing.

Science.gov (United States)

Kuang, Xiao; Chen, Kaijuan; Dunn, Conner K; Wu, Jiangtao; Li, Vincent C F; Qi, H Jerry

2018-02-28

The three-dimensional (3D) printing of flexible and stretchable materials with smart functions such as shape memory (SM) and self-healing (SH) is highly desirable for the development of future 4D printing technology for myriad applications, such as soft actuators, deployable smart medical devices, and flexible electronics. Here, we report a novel ink that can be used for the 3D printing of highly stretchable, SM, and SH elastomer via UV-light-assisted direct-ink-write printing. An ink containing urethane diacrylate and a linear semicrystalline polymer is developed for the 3D printing of a semi-interpenetrating polymer network elastomer that can be stretched by up to 600%. The 3D-printed complex structures show interesting functional properties, such as high strain SM and SM -assisted SH capability. We demonstrate that such a 3D-printed SM elastomer has the potential application for biomedical devices, such as vascular repair devices. This research paves a new way for the further development of novel 4D printing, soft robotics, and biomedical devices.

Cement analysis using d + D neutrons

International Nuclear Information System (INIS)

Womble, Phillip C.; Paschal, Jon; Moore, Ryan

2005-01-01

In the cement industry, the primary concern is quality control. The earlier the cement industry can institute quality control upon their product, the more significant their savings in labor, energy and material. We are developing a prototype cement analyzer using pulsed neutrons from a d-D electronic neutron generator with the goal of ensuring quality control of cement in an on-line manner. By utilizing a low intensity d-D neutron source and a specially-designed moderator assembly, we are able to produce one of the safest neutron-based systems in the market. Also, this design includes some exciting new methods of data acquisition which may substantially reduce the final installation costs. In our proof-of-principle measurements, we were able to measure the primary components of cement (Al, Si, Ca and Fe) to limits required for the raw materials, the derived mixes and the clinkers utilizing this neutron generator

Automatic intensity-based 3D-to-2D registration of CT volume and dual-energy digital radiography for the detection of cardiac calcification

Science.gov (United States)

Chen, Xiang; Gilkeson, Robert; Fei, Baowei

2007-03-01

We are investigating three-dimensional (3D) to two-dimensional (2D) registration methods for computed tomography (CT) and dual-energy digital radiography (DR) for the detection of coronary artery calcification. CT is an established tool for the diagnosis of coronary artery diseases (CADs). Dual-energy digital radiography could be a cost-effective alternative for screening coronary artery calcification. In order to utilize CT as the "gold standard" to evaluate the ability of DR images for the detection and localization of calcium, we developed an automatic intensity-based 3D-to-2D registration method for 3D CT volumes and 2D DR images. To generate digital rendering radiographs (DRR) from the CT volumes, we developed three projection methods, i.e. Gaussian-weighted projection, threshold-based projection, and average-based projection. We tested normalized cross correlation (NCC) and normalized mutual information (NMI) as similarity measurement. We used the Downhill Simplex method as the search strategy. Simulated projection images from CT were fused with the corresponding DR images to evaluate the localization of cardiac calcification. The registration method was evaluated by digital phantoms, physical phantoms, and clinical data sets. The results from the digital phantoms show that the success rate is 100% with mean errors of less 0.8 mm and 0.2 degree for both NCC and NMI. The registration accuracy of the physical phantoms is 0.34 +/- 0.27 mm. Color overlay and 3D visualization of the clinical data show that the two images are registered well. This is consistent with the improvement of the NMI values from 0.20 +/- 0.03 to 0.25 +/- 0.03 after registration. The automatic 3D-to-2D registration method is accurate and robust and may provide a useful tool to evaluate the dual-energy DR images for the detection of coronary artery calcification.

D-D neutron generator development at LBNL.

Science.gov (United States)

Reijonen, J; Gicquel, F; Hahto, S K; King, M; Lou, T-P; Leung, K-N

2005-01-01

The plasma and ion source technology group in Lawrence Berkeley National Laboratory is developing advanced, next generation D-D neutron generators. There are three distinctive developments, which are discussed in this presentation, namely, multi-stage, accelerator-based axial neutron generator, high-output co-axial neutron generator and point source neutron generator. These generators employ RF-induction discharge to produce deuterium ions. The distinctive feature of RF-discharge is its capability to generate high atomic hydrogen species, high current densities and stable and long-life operation. The axial neutron generator is designed for applications that require fast pulsing together with medium to high D-D neutron output. The co-axial neutron generator is aimed for high neutron output with cw or pulsed operation, using either the D-D or D-T fusion reaction. The point source neutron generator is a new concept, utilizing a toroidal-shaped plasma generator. The beam is extracted from multiple apertures and focus to the target tube, which is located at the middle of the generator. This will generate a point source of D-D, T-T or D-T neutrons with high output flux. The latest development together with measured data will be discussed in this article.

High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency

Directory of Open Access Journals (Sweden)

Amanda Zaleski

2015-01-01

Full Text Available Introduction. Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD. However, mechanisms underlying vitamin D deficiency-mediated increased risk of CVD remain unknown. We sought to examine the differential effect of high-dose versus low-dose vitamin D supplementation on markers of arterial stiffness among ~40 vitamin D deficient adults with prehypertension. Methods. Participants were randomized to high-dose (4000 IU/d versus low-dose (400 IU/d oral vitamin D3 for 6 months. 24 hr ambulatory blood pressure (BP, carotid-femoral pulse wave velocity, and pulse wave analyses were obtained at baseline and after 6 months of vitamin D supplementation. Results. There were no changes in resting BP or pulse wave velocity over 6 mo regardless of vitamin D dose (all p>0.202. High-dose vitamin D decreased augmentation index and pressure by 12.3 ± 5.3% (p=0.047 and 4.0 ± 1.5 mmHg (p=0.02, respectively. However, these decreases in arterial stiffness were not associated with increases in serum 25-hydroxyvitamin D over 6 mo (p=0.425. Conclusion. High-dose vitamin D supplementation appears to lower surrogate measures of arterial stiffness but not indices of central pulse wave velocity. Clinical Trial Registration. This trial is registered with www.clinicaltrials.gov (Unique Identifier: NCT01240512.

Development of high intensity beam handling system, 4

International Nuclear Information System (INIS)

Yamanoi, Yutaka; Tanaka, Kazuhiro; Minakawa, Michifumi

1992-01-01

We have constructed the new counter experimental hall at the KEK 12 GeV Proton Synchrotron (KEK-PS) in order to handle high intensity primary proton beams of up to 1x10 3 pps (protons per second), which is one order of magnitude greater than the present beam intensity of the KEK-PS, 1x10 12 pps. New technologies for handling high-intensity beams have, then, been developed and employed in the construction of the new hall. A part of our R/D work on handling high intensity beams will be reported. (author)

High-Precision Phenotyping of Grape Bunch Architecture Using Fast 3D Sensor and Automation

Directory of Open Access Journals (Sweden)

Florian Rist

2018-03-01

Full Text Available Wine growers prefer cultivars with looser bunch architecture because of the decreased risk for bunch rot. As a consequence, grapevine breeders have to select seedlings and new cultivars with regard to appropriate bunch traits. Bunch architecture is a mosaic of different single traits which makes phenotyping labor-intensive and time-consuming. In the present study, a fast and high-precision phenotyping pipeline was developed. The optical sensor Artec Spider 3D scanner (Artec 3D, L-1466, Luxembourg was used to generate dense 3D point clouds of grapevine bunches under lab conditions and an automated analysis software called 3D-Bunch-Tool was developed to extract different single 3D bunch traits, i.e., the number of berries, berry diameter, single berry volume, total volume of berries, convex hull volume of grapes, bunch width and bunch length. The method was validated on whole bunches of different grapevine cultivars and phenotypic variable breeding material. Reliable phenotypic data were obtained which show high significant correlations (up to r2 = 0.95 for berry number compared to ground truth data. Moreover, it was shown that the Artec Spider can be used directly in the field where achieved data show comparable precision with regard to the lab application. This non-invasive and non-contact field application facilitates the first high-precision phenotyping pipeline based on 3D bunch traits in large plant sets.

Multinational ownership and R&D intensity: The role of external knowledge sources and spillovers

OpenAIRE

De Beule, Filip; Van Beveren, Ilke

2011-01-01

This paper analyzes the drivers of multinational affiliates' R&D intensity, using a unique dataset based on the fourth Community Innovation Survey for Belgium. Specifically, we investigate the role of foreign affiliates' local (host country) embeddedness and of host country spillovers on foreign affiliates' research efforts. Our findings show that foreign affiliates who are able to tap into local knowledge sources demonstrate a higher research intensity, compared to firms lacking such access....

Screened Raman response in two-dimensional d(x2-y2)-wave superconductors: Relative intensities in different symmetry channels

DEFF Research Database (Denmark)

Wenger, F.; Käll, M.

1997-01-01

We analyze the Raman-scattering response in a two-dimensional d(x2-y2)-wave superconductor and point out a strong suppression of relative intensity in the screened A(1g) channel compared to the B-1g channel for a generic tight-binding model. This is in contrast with the observed behavior in high...

Highly efficient production of rare sugars D-psicose and L-tagatose by two engineered D-tagatose epimerases.

Science.gov (United States)

Bosshart, Andreas; Wagner, Nina; Lei, Lei; Panke, Sven; Bechtold, Matthias

2016-02-01

Rare sugars are monosaccharides that do not occur in nature in large amounts. However, many of them demonstrate high potential as low-calorie sweetener, chiral building blocks or active pharmaceutical ingredients. Their production by enzymatic means from broadly abundant epimers is an attractive alternative to synthesis by traditional organic chemical means, but often suffers from low space-time yields and high enzyme costs due to rapid enzyme degradation. Here we describe the detailed characterization of two variants of d-tagatose epimerase under operational conditions that were engineered for high stability and high catalytic activity towards the epimerization of d-fructose to d-psicose and l-sorbose to l-tagatose, respectively. A variant optimized for the production of d-psicose showed a very high total turnover number (TTN) of up to 10(8) catalytic events over a catalyst's lifetime, determined under operational conditions at high temperatures in an enzyme-membrane reactor (EMR). Maximum space-time yields as high as 10.6 kg L(-1) d(-1) were obtained with a small laboratory-scale EMR, indicating excellent performance. A variant optimized for the production of l-tagatose performed less stable in the same setting, but still showed a very good TTN of 5.8 × 10(5) and space-time yields of up to 478 g L(-1) d(-1) . Together, these results confirm that large-scale enzymatic access to rare sugars is feasible. © 2015 Wiley Periodicals, Inc.

Anal wall sparing effect of an endorectal balloon in 3D conformal and intensity-modulated prostate radiotherapy.

Science.gov (United States)

Smeenk, Robert Jan; van Lin, Emile N J Th; van Kollenburg, Peter; Kunze-Busch, Martina; Kaanders, Johannes H A M

2009-10-01

To investigate the anal wall (Awall) sparing effect of an endorectal balloon (ERB) in 3D conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for prostate cancer. In 24 patients with localized prostate carcinoma, two planning CT-scans were performed: with and without ERB. A prostate planning target volume (PTV) was defined, and the Awall was delineated, using two different methods. Three-field and 4-field 3D-CRT plans, and IMRT plans were generated with a prescription dose of 78Gy. In 144 treatment plans, the minimum dose (D(min)), maximum dose (D(max)), and mean dose (D(mean)) to the Awall were calculated, as well as the Awall volumes exposed to doses ranging from >or=20Gy to >or=70Gy (V(20)-V(70), respectively). In the 3D-CRT plans, an ERB significantly reduced D(mean), D(max), and V(30)-V(70). For IMRT all investigated dose parameters were significantly reduced by the ERB. The absolute reduction of D(mean) was 12Gy in 3D-CRT and was 7.5Gy in IMRT for both methods of Awall delineation. Application of an ERB showed a significant Awall sparing effect in both 3D-CRT and IMRT. This may lead to reduced late anal toxicity in prostate radiotherapy.

High d(+)-fructose diet adversely affects testicular weight gain in weaning rats─protection by moderate d(+)-glucose diet.

Science.gov (United States)

Shibata, Katsumi; Fukuwatari, Tsutomu

2013-01-01

The use of high D(+)-fructose corn syrup has increased over the past several decades in the developed countries, while overweight and obesity rates and the related diseases have risen dramatically. However, we found that feeding a high D(+)-fructose diet (80% D(+)-fructose as part of the diet) to weaning rats for 21 days led to reduced food intake (50% less, P fructose diet. We also challenged a minimum requirement of dietary D(+)-glucose for preventing the adverse effects of D(+)-fructose, such as lower food intake and reduction of body weight and testicular weight; the minimum requirement of D(+)-glucose was ≈23% of the diet. This glucose amount may be the minimum requirement of exogenous glucose for reducing weight gain.

Comparing two strategies of dynamic intensity modulated radiation therapy (dIMRT) with 3-dimensional conformal radiation therapy (3DCRT) in the hypofractionated treatment of high-risk prostate cancer

International Nuclear Information System (INIS)

Yuen, Jasper; Rodrigues, George; Trenka, Kristina; Coad, Terry; Yartsev, Slav; D'Souza, David; Lock, Michael; Bauman, Glenn

2008-01-01

To compare two strategies of dynamic intensity modulated radiation therapy (dIMRT) with 3-dimensional conformal radiation therapy (3DCRT) in the setting of hypofractionated high-risk prostate cancer treatment. 3DCRT and dIMRT/Helical Tomotherapy(HT) planning with 10 CT datasets was undertaken to deliver 68 Gy in 25 fractions (prostate) and simultaneously delivering 45 Gy in 25 fractions (pelvic lymph node targets) in a single phase. The paradigms of pelvic vessel targeting (iliac vessels with margin are used to target pelvic nodes) and conformal normal tissue avoidance (treated soft tissues of the pelvis while limiting dose to identified pelvic critical structures) were assessed compared to 3DCRT controls. Both dIMRT/HT and 3DCRT solutions were compared to each other using repeated measures ANOVA and post-hoc paired t-tests. When compared to conformal pelvic vessel targeting, conformal normal tissue avoidance delivered more homogenous PTV delivery (2/2 t-test comparisons; p < 0.001), similar nodal coverage (8/8 t-test comparisons; p = ns), higher and more homogenous pelvic tissue dose (6/6 t-test comparisons; p < 0.03), at the cost of slightly higher critical structure dose (D dose , 1–3 Gy over 5/10 dose points; p < 0.03). The dIMRT/HT approaches were superior to 3DCRT in sparing organs at risk (22/24 t-test comparisons; p < 0.05). dIMRT/HT nodal and pelvic targeting is superior to 3DCRT in dose delivery and critical structure sparing in the setting of hypofractionation for high-risk prostate cancer. The pelvic targeting paradigm is a potential solution to deliver highly conformal pelvic radiation treatment in the setting of nodal location uncertainty in prostate cancer and other pelvic malignancies

Fusion blankets for catalyzed D--D and D--He3 reactors

International Nuclear Information System (INIS)

Fillo, J.A.; Powell, J.R.

1977-01-01

Blanket designs are presented for catalyzed D-D (Cat-D) and D-He 3 fusion reactors. Because of relatively low neutron wall loads and the flexibility due to non-tritium breeding, blankets potentially should operate for reactor life-times of approximately 30 years. Unscheduled replacement of failed blanket modules should be relatively rapid, due to very low residual activity, by operators working either through access ports in the shield (option 1) or directly in the plasma chamber (option 2). Cat-D blanket designs are presented for high (approximately 30%) and low (approximately 12%) β noncircular Tokamak reactors. The blankets are thick graphite screens, operating at high temperature to anneal radiation damage; the deposited neutron and gamma energy is thermally radiated along internal cavities and conducted to a bank of internal SiC coolant tubes (approximately 4 cm. ID) containing high pressure helium. In the D-He 3 Tokamak reactor design, the blanket consists of multiple layers (e.g., three) of thin (approximately 10 cm.) high strength aluminum (e.g., SAP), modular plates, cooled by organic terphynyl coolant

Fusion blankets for catalyzed D--D and D--3He reactors

International Nuclear Information System (INIS)

Fillo, J.A.; Powell, J.R.

1977-01-01

Blanket designs are presented for catalyzed D-D (Cat-D) and D-He 3 fusion reactors. Because of relatively low neutron wall loads and the flexibility due to non-tritium breeding, blankets potentially should operate for reactor life-times of approximately 30 years. Unscheduled replacement of failed blanket modules should be relatively rapid, due to very low residual activity, by operators working either through access ports in the shield (option 1) or directly in the plasma chamber (option 2). Cat-D blanket designs are presented for high (approximately 30%) and low (approximately 12%) β non-circular Tokamak reactors. The blankets are thick graphite screens, operating at high temperature to anneal radiation damage; the deposited neutron and gamma energy is thermally radiated along internal cavities and conducted to a bank of internal SiC coolant tubes (approximately 4 cm. ID) containing high pressure helium. In the D-He 3 Tokamak reactor design, the blanket consists of multiple layers (e.g., three) of thin (approximately 10 cm.) high strength aluminum (e.g., SAP), modular plates, cooled by organic terphenyl coolant

Four-dimensional (4D) tracking of high-temperature microparticles

International Nuclear Information System (INIS)

Wang, Zhehui; Liu, Q.; Waganaar, W.; Fontanese, J.; James, D.; Munsat, T.

2016-01-01

High-speed tracking of hot and molten microparticles in motion provides rich information about burning plasmas in magnetic fusion. An exploding-wire apparatus is used to produce moving high-temperature metallic microparticles and to develop four-dimensional (4D) or time-resolved 3D particle tracking techniques. The pinhole camera model and algorithms developed for computer vision are used for scene calibration and 4D reconstructions. 3D positions and velocities are then derived for different microparticles. Velocity resolution approaches 0.1 m/s by using the local constant velocity approximation.

R&D INTENSITY AND IPO UNDERPRICING: CASE STUDY ON PHARMACEUTICAL AND BIOTECH INDUSTRIES IN THE US

Directory of Open Access Journals (Sweden)

Tommy C. Efrata

2016-02-01

Full Text Available Asymmetric information between the issuer to potential investors believed by some academics in finance as one of the main causes of the phenomenon of underpricing at the time of the initial public offering (IPO. On science and technology-based company main problem lies in how to conduct assessments on the future value of a product that is still in the development stage. The issue became more prominent on pharmaceutical companies and biotechnology, due to the characteristics of this industry is the high expense, complex process, and the lengthy process of research and development (R & D of a product. This study describes the characteristics above is associated with the phenomenon of underpricing when companies conduct IPO. The samples are 82 pharmaceutical companies and biotechnology conduct IPO in the United States stock market in 1998-2005. The results of this study revealed a negative correlation between the intensity of R & D and IPO underpricing phenomenon in this industry. These studies have identified R & D as the main source of information asymmetry that led to the phenomenon of underpricing for pharmaceutical companies and biotechnology.

High performance with modified shear in JET D-D and D-T plasmas

International Nuclear Information System (INIS)

2001-01-01

The observation of Internal Transport Barriers (ITBs) in which ion thermal diffusivity is reduced to a neo- classical level and the electron thermal diffusivity is substantially reduced has been made in JET with the optimised shear scenario with the MkII divertor both in D-D and in D-T. Central ion temperatures of 40keV and plasma pressure gradient of 10 6 Pa/m were observed in D-T leading to a fusion triple product n i T i τ E =1x10 21 m -3 keVs and 8.2MW of fusion power. ITBs have also been produced in the new Gas Box divertor configuration with a similar behaviour. With the new divertor an L-mode edge has only been produced using edge radiation cooling. For the first time, ITBs have been triggered by radiating about 40% of the power with a krypton puff. A tentative scaling of the power needed to trigger an ITB with magnetic field is indicated. (author)

Modeling and simulation of a 3D-CMOS silicon photodetector for low-intensity light detection

Science.gov (United States)

Sabri Alirezaei, Iman; Burte, Edmund P.

2016-03-01

This paper presents a design and simulation of a novel high performance 3D-silicon photodetector for implementing in the low intensity light detection at room temperature (300K). The photodetector is modeled by inspiration of general MEMS fabrication to make a 3D- structure in the silicon substrate using a bulk micromachining process, and based on a complementary metal-oxide semiconductor (CMOS) technology. The design includes a vertical n+/p junction as an optical window for lateral illumination. The simulation is carried out using COMSOL Multiphysics relying on theoretical and physical concepts, and then, the assessment of the results is done by the numerical analysis with SILVACO (Atlas) device simulator. Light is regarded as a monochromatic beam with a wavelength of 633nm that is placed 1μm far from the optical window. The simulation is considered under the reverse bias dc voltage in the steadystate. We present photocurrent-voltage (Iph-V) characteristics under different light intensities (2… 10[mW/cm2]), and dark current-voltage (Id-V) characteristics. Comparative studies of sensitivity dependence on the dopant concentration in the substrate as an intrinsic region are accomplished utilizing two different p-type silicon substrates with 1×1015 [1/cm3] and 4×1012 [1/cm3] doping concentration. Moreover, the sensitivity is evaluated with respect to the active substrate thickness. The simulated results confirmed that the high optical sensitivity of the photodetector with low dark current can be realized in this model.

The High Prevalence of Vitamin D Insufficiency in Cord Blood in Calgary, Alberta (APrON-D Study).

Science.gov (United States)

Aghajafari, Fariba; Field, Catherine J; Kaplan, Bonnie J; Maggiore, Jack A; O'Beirne, Maeve; Hanley, David A; Eliasziw, Misha; Dewey, Deborah; Ross, Sue; Rabi, Doreen

2017-05-01

Vitamin D is important in promoting healthy pregnancy and fetal development. We undertook this study to measure 25-hydroxyvitamin D in maternal and cord blood and to identify maternal factors related to vitamin D status in Calgary. Blood samples collected at the time of delivery from the Alberta Pregnancy Outcomes and Nutrition study cohort (ApronStudy.ca) participants were processed for plasma and assayed using liquid chromatography mass spectrometry methodology for 25(OH)D 3 . Ninety-two pairs of maternal and cord blood samples were obtained. The prevalence of 25(OH)D 3 insufficiency-25(OH)D 3 <75 nmol/L-was 38% and 80% in women and neonates, respectively. Vitamin D supplementation was the only clinical factor associated with 25(OH)D 3 sufficiency, and the odds of sufficiency were 3.75 (95% CI 1.00 to 14.07) higher for women and 5.27 (95% CI 1.37 to 20.27) when over 2000 IU/day were used. Using liquid chromatography mass spectrometry, we demonstrated a very high prevalence of vitamin D insufficiency in cord blood and that the use of high dose vitamin D was associated with greater odds of sufficiency in pregnant women and cord blood in Alberta. Copyright © 2017 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.

R & D of a Gas-Filled RF Beam Profile Monitor for Intense Neutrino Beam Experiments

Energy Technology Data Exchange (ETDEWEB)

Yonehara, K. [Fermilab; Backfish, M. [Fermilab; Moretti, A. [Fermilab; Tollestrup, A. V. [Fermilab; Watts, A. [Fermilab; Zwaska, R. M. [Fermilab; Abrams, R. [MUONS Inc., Batavia; Cummings, M. A.; Dudas, A. [MUONS Inc., Batavia; Johnson, R. P. [MUONS Inc., Batavia; Kazakevich, G. [MUONS Inc., Batavia; Neubauer, M. [MUONS Inc., Batavia; Liu, Q. [Case Western Reserve U.

2017-05-01

We report the R&D of a novel radiation-robust hadron beam profile monitor based on a gas-filled RF cavity for intense neutrino beam experiments. An equivalent RF circuit model was made and simulated to optimize the RF parameter in a wide beam intensity range. As a result, the maximum acceptable beam intensity in the monitor is significantly increased by using a low-quality factor RF cavity. The plan for the demonstration test is set up to prepare for future neutrino beam experiments.

High-Speed 3D Printing of High-Performance Thermosetting Polymers via Two-Stage Curing.

Science.gov (United States)

Kuang, Xiao; Zhao, Zeang; Chen, Kaijuan; Fang, Daining; Kang, Guozheng; Qi, Hang Jerry

2018-04-01

Design and direct fabrication of high-performance thermosets and composites via 3D printing are highly desirable in engineering applications. Most 3D printed thermosetting polymers to date suffer from poor mechanical properties and low printing speed. Here, a novel ink for high-speed 3D printing of high-performance epoxy thermosets via a two-stage curing approach is presented. The ink containing photocurable resin and thermally curable epoxy resin is used for the digital light processing (DLP) 3D printing. After printing, the part is thermally cured at elevated temperature to yield an interpenetrating polymer network epoxy composite, whose mechanical properties are comparable to engineering epoxy. The printing speed is accelerated by the continuous liquid interface production assisted DLP 3D printing method, achieving a printing speed as high as 216 mm h -1 . It is also demonstrated that 3D printing structural electronics can be achieved by combining the 3D printed epoxy composites with infilled silver ink in the hollow channels. The new 3D printing method via two-stage curing combines the attributes of outstanding printing speed, high resolution, low volume shrinkage, and excellent mechanical properties, and provides a new avenue to fabricate 3D thermosetting composites with excellent mechanical properties and high efficiency toward high-performance and functional applications. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

2D and 3D milled surface roughness of high volume fraction SiCp/Al composites

Directory of Open Access Journals (Sweden)

Tao Wang

2015-06-01

Full Text Available This paper presents a study on surface roughness generated by high speed milling of high volume fraction (65% silicon carbide particle-reinforced aluminum matrix (SiCp/Al composites. Typical 2D (Ra and Rz and 3D (Sa and Sq surface roughness parameters were selected to evaluate the influence of the milling parameters on the surface quality in comparison with aluminum alloy. The 3D topography of the milled surface was studied as well. The results indicate that 3D parameters (Sa and Sq are more capable to describe the influence of the milling parameters on the surface quality, and among them Sq is preferable due to its good sensitivity. Sq decreases with milling speed and increases with feed rate. The influence of axial depth of cut (ADOC is negligible.

Correlations between D and D-bar mesons in high energy photoproduction

International Nuclear Information System (INIS)

Gottschalk, Erik E.; Link, J.; Reyes, M.; Yager, P.M.; Anjos, J.; Bediaga, I.; Gobel, C.; Magnin, J.; Massafferri, A.; Miranda, J.M. de; Pepe, I.M.; Reis, A.C. dos; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sanchez-Hernandez, A.; Uribe, C.; Vasquez, F.; Agostino, L.; Cinquini, L.; Cumalat, J.P.; O'Reilly, B.; Ramirez, J.E.; Segoni, I.; Butler, J.N.; Cheung, H.W.K.; Chiodini, G.; Gaines, I.; Garbincius, P.H.; Garren, L.A.; Gottschalk, E.E.; Kasper, P.H.; Kreymer, A.E.; Kutschke, R.; Benussi, L.; Bianco, S.; Fabbri, F.L.; Zallo, A.; Cawlfield, C.; Kim, D.Y.; Park, K.S.; Rahimi, A.; Wiss, J.; Gardner, R.; Kryemadhi, A.; Chang, K.H.; Chung, Y.S.; Kang, J.S.; Ko, B.R.; Kwak, J.W.; Lee, K.B.; Cho, K.; Park, H.; Alimonti, G.; Barberis, S.; Cerutti, A.; Boschini, M.; D'Angelo, P.; DiCorato, M.; Dini, P.; Edera, L.; Erba, S.; Giammarchi, M.; Inzani, P.; Leveraro, F.; Malvezzi, S.; Menasce, D.; Mezzadri, M.; Moroni, L.; Pedrini, D.; Pontoglio, C.; Prelz, F.; Rovere, M.; Sala, S.; Davenport, T.F.; Arena, V.; Boca, G.; Bonomi, G.; Gianini, G.; Liguori, G.; Merlo, M.M.; Pantea, D.; Ratti, S.P.; Vitulo, P.; Hernandez, H.; Lopez, A.M.; Mendez, H.; Mendez, L.; Montiel, E.; Olaya, D.; Paris, A.; Quinones, J.; Rivera, C.; Xiong, W.; Zhang, Y.; Wilson, J.R.; Handler, T.; Mitchell, R.; Engh, D.; Hosack, M.; Johns, W.E.; Nehring, M.; Sheldon, P.D.; Stenson, K.; Vaadering, E.W.; Webster, M.; Sheaff, M.

2003-01-01

Over 7000 events containing a fully reconstructed D D-bar pair have been extracted from data recorded by the FOCUS photoproduction experiment at Fermilab. Preliminary results from a study of correlations between D and D-bar mesons are presented. Correlations are used to study perturbative QCD predictions and investigate non-perturbative effects. We also present a preliminary result on the production of Ψ(3770)

High D(+-Fructose Diet Adversely Affects Testicular Weight Gain in Weaning Rats—Protection by Moderate D(+-Glucose Diet

Directory of Open Access Journals (Sweden)

Katsumi Shibata

2013-01-01

Full Text Available The use of high D(+-fructose corn syrup has increased over the past several decades in the developed countries, while overweight and obesity rates and the related diseases have risen dramatically. However, we found that feeding a high D(+-fructose diet (80% D(+-fructose as part of the diet to weaning rats for 21 days led to reduced food intake (50% less, P < 0.0001 and thus delayed the weight gains in the body (40% less, P < 0.0001 and testes (40% less, P < 0.0001 compared to the no D(+-fructose diet. We also challenged a minimum requirement of dietary D(+-glucose for preventing the adverse effects of D(+-fructose, such as lower food intake and reduction of body weight and testicular weight; the minimum requirement of D(+-glucose was ã23% of the diet. This glucose amount may be the minimum requirement of exogenous glucose for reducing weight gain.

Crop 3D-a LiDAR based platform for 3D high-throughput crop phenotyping.

Science.gov (United States)

Guo, Qinghua; Wu, Fangfang; Pang, Shuxin; Zhao, Xiaoqian; Chen, Linhai; Liu, Jin; Xue, Baolin; Xu, Guangcai; Li, Le; Jing, Haichun; Chu, Chengcai

2018-03-01

With the growing population and the reducing arable land, breeding has been considered as an effective way to solve the food crisis. As an important part in breeding, high-throughput phenotyping can accelerate the breeding process effectively. Light detection and ranging (LiDAR) is an active remote sensing technology that is capable of acquiring three-dimensional (3D) data accurately, and has a great potential in crop phenotyping. Given that crop phenotyping based on LiDAR technology is not common in China, we developed a high-throughput crop phenotyping platform, named Crop 3D, which integrated LiDAR sensor, high-resolution camera, thermal camera and hyperspectral imager. Compared with traditional crop phenotyping techniques, Crop 3D can acquire multi-source phenotypic data in the whole crop growing period and extract plant height, plant width, leaf length, leaf width, leaf area, leaf inclination angle and other parameters for plant biology and genomics analysis. In this paper, we described the designs, functions and testing results of the Crop 3D platform, and briefly discussed the potential applications and future development of the platform in phenotyping. We concluded that platforms integrating LiDAR and traditional remote sensing techniques might be the future trend of crop high-throughput phenotyping.

Comparing two strategies of dynamic intensity modulated radiation therapy (dIMRT with 3-dimensional conformal radiation therapy (3DCRT in the hypofractionated treatment of high-risk prostate cancer

Directory of Open Access Journals (Sweden)

Yartsev Slav

2008-01-01

Full Text Available Abstract Background To compare two strategies of dynamic intensity modulated radiation therapy (dIMRT with 3-dimensional conformal radiation therapy (3DCRT in the setting of hypofractionated high-risk prostate cancer treatment. Methods 3DCRT and dIMRT/Helical Tomotherapy(HT planning with 10 CT datasets was undertaken to deliver 68 Gy in 25 fractions (prostate and simultaneously delivering 45 Gy in 25 fractions (pelvic lymph node targets in a single phase. The paradigms of pelvic vessel targeting (iliac vessels with margin are used to target pelvic nodes and conformal normal tissue avoidance (treated soft tissues of the pelvis while limiting dose to identified pelvic critical structures were assessed compared to 3DCRT controls. Both dIMRT/HT and 3DCRT solutions were compared to each other using repeated measures ANOVA and post-hoc paired t-tests. Results When compared to conformal pelvic vessel targeting, conformal normal tissue avoidance delivered more homogenous PTV delivery (2/2 t-test comparisons; p dose, 1–3 Gy over 5/10 dose points; p Conclusion dIMRT/HT nodal and pelvic targeting is superior to 3DCRT in dose delivery and critical structure sparing in the setting of hypofractionation for high-risk prostate cancer. The pelvic targeting paradigm is a potential solution to deliver highly conformal pelvic radiation treatment in the setting of nodal location uncertainty in prostate cancer and other pelvic malignancies.

Involved-Site Image-Guided Intensity Modulated Versus 3D Conformal Radiation Therapy in Early Stage Supradiaphragmatic Hodgkin Lymphoma

Energy Technology Data Exchange (ETDEWEB)

Filippi, Andrea Riccardo, E-mail: andreariccardo.filippi@unito.it [Department of Oncology, University of Torino, Torino (Italy); Ciammella, Patrizia [Radiation Therapy Unit, Department of Oncology and Advanced Technology, ASMN Hospital IRCCS, Reggio Emilia (Italy); Piva, Cristina; Ragona, Riccardo [Department of Oncology, University of Torino, Torino (Italy); Botto, Barbara [Hematology, Città della Salute e della Scienza, Torino (Italy); Gavarotti, Paolo [Hematology, University of Torino and Città della Salute e della Scienza, Torino (Italy); Merli, Francesco [Hematology Unit, ASMN Hospital IRCCS, Reggio Emilia (Italy); Vitolo, Umberto [Hematology, Città della Salute e della Scienza, Torino (Italy); Iotti, Cinzia [Radiation Therapy Unit, Department of Oncology and Advanced Technology, ASMN Hospital IRCCS, Reggio Emilia (Italy); Ricardi, Umberto [Department of Oncology, University of Torino, Torino (Italy)

2014-06-01

Purpose: Image-guided intensity modulated radiation therapy (IG-IMRT) allows for margin reduction and highly conformal dose distribution, with consistent advantages in sparing of normal tissues. The purpose of this retrospective study was to compare involved-site IG-IMRT with involved-site 3D conformal RT (3D-CRT) in the treatment of early stage Hodgkin lymphoma (HL) involving the mediastinum, with efficacy and toxicity as primary clinical endpoints. Methods and Materials: We analyzed 90 stage IIA HL patients treated with either involved-site 3D-CRT or IG-IMRT between 2005 and 2012 in 2 different institutions. Inclusion criteria were favorable or unfavorable disease (according to European Organization for Research and Treatment of Cancer criteria), complete response after 3 to 4 cycles of an adriamycin- bleomycin-vinblastine-dacarbazine (ABVD) regimen plus 30 Gy as total radiation dose. Exclusion criteria were chemotherapy other than ABVD, partial response after ABVD, total radiation dose other than 30 Gy. Clinical endpoints were relapse-free survival (RFS) and acute toxicity. Results: Forty-nine patients were treated with 3D-CRT (54.4%) and 41 with IG-IMRT (45.6%). Median follow-up time was 54.2 months for 3D-CRT and 24.1 months for IG-IMRT. No differences in RFS were observed between the 2 groups, with 1 relapse each. Three-year RFS was 98.7% for 3D-CRT and 100% for IG-IMRT. Grade 2 toxicity events, mainly mucositis, were recorded in 32.7% of 3D-CRT patients (16 of 49) and in 9.8% of IG-IMRT patients (4 of 41). IG-IMRT was significantly associated with a lower incidence of grade 2 acute toxicity (P=.043). Conclusions: RFS rates at 3 years were extremely high in both groups, albeit the median follow-up time is different. Acute tolerance profiles were better for IG-IMRT than for 3D-CRT. Our preliminary results support the clinical safety and efficacy of advanced RT planning and delivery techniques in patients affected with early stage HL, achieving complete

Anal wall sparing effect of an endorectal balloon in 3D conformal and intensity-modulated prostate radiotherapy

International Nuclear Information System (INIS)

Smeenk, Robert Jan; Lin, Emile N.J.Th. van; Kollenburg, Peter van; Kunze-Busch, Martina; Kaanders, Johannes H.A.M.

2009-01-01

Background and purpose: To investigate the anal wall (Awall) sparing effect of an endorectal balloon (ERB) in 3D conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for prostate cancer. Materials and methods: In 24 patients with localized prostate carcinoma, two planning CT-scans were performed: with and without ERB. A prostate planning target volume (PTV) was defined, and the Awall was delineated, using two different methods. Three-field and 4-field 3D-CRT plans, and IMRT plans were generated with a prescription dose of 78 Gy. In 144 treatment plans, the minimum dose (D min ), maximum dose (D max ), and mean dose (D mean ) to the Awall were calculated, as well as the Awall volumes exposed to doses ranging from ≥20 Gy to ≥70 Gy (V 20 - V 70 , respectively). Results: In the 3D-CRT plans, an ERB significantly reduced D mean , D max , and V 30 - V 70 . For IMRT all investigated dose parameters were significantly reduced by the ERB. The absolute reduction of D mean was 12 Gy in 3D-CRT and was 7.5 Gy in IMRT for both methods of Awall delineation. Conclusions: Application of an ERB showed a significant Awall sparing effect in both 3D-CRT and IMRT. This may lead to reduced late anal toxicity in prostate radiotherapy.

R&D and Price Elasticity of Demand

DEFF Research Database (Denmark)

Lucke, D.; Schröder, Philipp; D., Schumacher,

2004-01-01

This paper explores the relationship between the price elasticity of demand and the R&D intensity of the product. We introduce the concept of R&D intensity into a standard Dixit-Stiglitz/Krugman-type setting. R&D activity is treated as a fixed cost of production. Within this framework, sectors...... with a higher R&D intensity show a lower price elasticity of demand. This proposition is confirmed by an empirical investigation of export demand for manufactured goods from major industrialised countries. Consequently, real exchange rate changes have an impact on the commodity structure of exports....

Color suppressed contributions to the decay modes Bd,s→Ds,dDs,d, Bd,s→Ds,dD*s,d, and Bd,s→D*s,d D*s,d

International Nuclear Information System (INIS)

Eeg, J.O.; Fajfer, S.; Prapotnik, A.

2005-01-01

The amplitudes for decays of the type B d,s →D s,d D s,d , have no factorizable contributions, while B d,s →D s,d D * s,d , and B d,s →D * s,d D * s,d have relatively small factorizable contributions through the annihilation mechanism. The dominant contributions to the decay amplitudes arise from chiral loop contributions and tree level amplitudes which can be obtained in terms of soft gluon emissions forming a gluon condensate. We predict that the branching ratios for the processes anti B 0 d →D s + D s - , anti B 0 d →D s +* D s - and anti B 0 d →D s + D s -* are all of order (2-3) x 10 -4 , while anti B 0 s →D d + D d - , anti B 0 s →D d +* D d - and anti B 0 s →D d + D d -* are of order (4-7) x 10 -3 . We obtain branching ratios for two D * 's in the final state of order two times bigger. (orig.)

Color suppressed contributions to the decay modes B{sub d,s}{yields}D{sub s,d}D{sub s,d}, B{sub d,s}{yields}D{sub s,d}D{sup *}{sub s,d}, and B{sub d,s}{yields}D{sup *}{sub s,d} D{sup *}{sub s,d}

Energy Technology Data Exchange (ETDEWEB)

Eeg, J.O. [University of Oslo, Department of Physics, Blindern, Oslo (Norway); Fajfer, S. [University of Ljubljana, Department of Physics, Ljubljana (Slovenia); J. Stefan Institute, Ljubljana (Slovenia); Prapotnik, A. [J. Stefan Institute, Ljubljana (Slovenia)

2005-07-01

The amplitudes for decays of the type B{sub d,s}{yields}D{sub s,d}D{sub s,d}, have no factorizable contributions, while B{sub d,s}{yields}D{sub s,d}D{sup *}{sub s,d}, and B{sub d,s}{yields}D{sup *}{sub s,d}D{sup *}{sub s,d} have relatively small factorizable contributions through the annihilation mechanism. The dominant contributions to the decay amplitudes arise from chiral loop contributions and tree level amplitudes which can be obtained in terms of soft gluon emissions forming a gluon condensate. We predict that the branching ratios for the processes anti B{sup 0}{sub d}{yields}D{sub s}{sup +}D{sub s}{sup -}, anti B{sup 0}{sub d}{yields}D{sub s}{sup +*} D{sub s}{sup -} and anti B{sup 0}{sub d}{yields}D{sub s}{sup +}D{sub s}{sup -*} are all of order (2-3) x 10{sup -4}, while anti B{sup 0}{sub s}{yields}D{sub d}{sup +}D{sub d}{sup -}, anti B{sup 0}{sub s}{yields}D{sub d}{sup +*}D{sub d}{sup -} and anti B{sup 0}{sub s}{yields}D{sub d}{sup +}D{sub d}{sup -*} are of order (4-7) x 10{sup -3}. We obtain branching ratios for two D{sup *}'s in the final state of order two times bigger. (orig.)

A case of high-titer anti-D hemolytic disease of the newborn in which late onset and mild course is associated with the D variant, RHD-CE(9)-D.

Science.gov (United States)

Jakobsen, Marianne A; Nielsen, Christian; Sprogøe, Ulrik

2014-10-01

The RhD antigen is very immunogenic and is a significant cause of hemolytic disease of the newborn (HDN). The RHD-CE(8-9)-D hybrid allele is commonly associated with a D- phenotype. Here, we report a case of high-titer maternal anti-D and late onset of HDN in a newborn carrying a RHD-CE(9)-D variant supposedly encoding the same partial D antigen as the RHD-CE(8-9)-D allele, but with significant expression of D antigen. To elucidate the blood group antigen background of the case, we carried out serologic, flow cytometric, and genetics studies of the newborn and his father. Individuals carrying the RHD-CE(9)-D allele do express D antigen, but do so at significantly lower levels than those carrying the more common D+ phenotypes (e.g., DCe/dce). It may mitigate and delay otherwise severe HDN in pregnancies complicated by high-titer anti-D. © 2014 AABB.

Experimental studies on the X-radiation from a high-intensity annular discharge; Etudes experimentales sur le rayonnement X d'une decharge annulaire a forte intensite

Energy Technology Data Exchange (ETDEWEB)

Etievant, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

Under certain conditions, a very penetrating X-radiation is emitted at the start of a stabilised annular discharge. A number of experimental observations have been made using a pyrex toroid filled with deuterium or argon. The value of the stabilising magnetic field and the pressure have a very important influence on the intensity of the X-radiation emitted. The placing of an obstacle such as a magnetic mirror at a point of the torus can prevent the acceleration of runaway electrons during successive revolutions, and X-ray emission disappears. (author) [French] Un rayonnement X tres penetrant est emis dans certaines conditions au debut d'une decharge annulaire stabilisee. Un certain nombre d'observations experimentales ont ete faites a l'aide d'un tore en pyrex rempli de deuterium ou d'argon. La valeur du champ magnetique stabilisateur et la pression jouent un role tres important sur l'intensite du rayonnement X emis. La disposition d'un obstacle tel qu'un miroir magnetique en un point du tore peut empecher l'acceleration d'electrons decouples au cours de revolutions successives et l'emission de rayonnement X disparait. (auteur)

Intensity-based segmentation and visualization of cells in 3D microscopic images using the GPU

Science.gov (United States)

Kang, Mi-Sun; Lee, Jeong-Eom; Jeon, Woong-ki; Choi, Heung-Kook; Kim, Myoung-Hee

2013-02-01

3D microscopy images contain abundant astronomical data, rendering 3D microscopy image processing time-consuming and laborious on a central processing unit (CPU). To solve these problems, many people crop a region of interest (ROI) of the input image to a small size. Although this reduces cost and time, there are drawbacks at the image processing level, e.g., the selected ROI strongly depends on the user and there is a loss in original image information. To mitigate these problems, we developed a 3D microscopy image processing tool on a graphics processing unit (GPU). Our tool provides efficient and various automatic thresholding methods to achieve intensity-based segmentation of 3D microscopy images. Users can select the algorithm to be applied. Further, the image processing tool provides visualization of segmented volume data and can set the scale, transportation, etc. using a keyboard and mouse. However, the 3D objects visualized fast still need to be analyzed to obtain information for biologists. To analyze 3D microscopic images, we need quantitative data of the images. Therefore, we label the segmented 3D objects within all 3D microscopic images and obtain quantitative information on each labeled object. This information can use the classification feature. A user can select the object to be analyzed. Our tool allows the selected object to be displayed on a new window, and hence, more details of the object can be observed. Finally, we validate the effectiveness of our tool by comparing the CPU and GPU processing times by matching the specification and configuration.

H/D isotope effects in high temperature proton conductors

DEFF Research Database (Denmark)

Bonanos, Nikolaos; Huijser, A.; Poulsen, Finn Willy

2015-01-01

The atomic mass ratio of ca. 2 between deuterium and hydrogen is the highest for any pair of stable isotopes and results in significant and measurable H/D isotope effects in high temperature proton conductors containing these species. This paper discusses H/D isotope effects manifested in O-H/O-D...

Vitamin D and Anaesthesia

OpenAIRE

Biricik, Ebru; Güneş, Yasemin

2015-01-01

Vitamin D is a vitamin not only associated with calcium-phosphorus metabolism but also affects many organ systems. Because of its effect on the immune system in recent years, it has attracted much attention. Vitamin D deficiency is a clinical condition that can be widely observed in the society. Thus, patients with vitamin D deficiency are often seen in anaesthesia practice. In the absence of vitamin D, prolongation of intensive care unit stay, increase in mortality and morbidity and also ass...

3D-2D registration in endovascular image-guided surgery: evaluation of state-of-the-art methods on cerebral angiograms.

Science.gov (United States)

Mitrović, Uroš; Likar, Boštjan; Pernuš, Franjo; Špiclin, Žiga

2018-02-01

Image guidance for minimally invasive surgery is based on spatial co-registration and fusion of 3D pre-interventional images and treatment plans with the 2D live intra-interventional images. The spatial co-registration or 3D-2D registration is the key enabling technology; however, the performance of state-of-the-art automated methods is rather unclear as they have not been assessed under the same test conditions. Herein we perform a quantitative and comparative evaluation of ten state-of-the-art methods for 3D-2D registration on a public dataset of clinical angiograms. Image database consisted of 3D and 2D angiograms of 25 patients undergoing treatment for cerebral aneurysms or arteriovenous malformations. On each of the datasets, highly accurate "gold-standard" registrations of 3D and 2D images were established based on patient-attached fiducial markers. The database was used to rigorously evaluate ten state-of-the-art 3D-2D registration methods, namely two intensity-, two gradient-, three feature-based and three hybrid methods, both for registration of 3D pre-interventional image to monoplane or biplane 2D images. Intensity-based methods were most accurate in all tests (0.3 mm). One of the hybrid methods was most robust with 98.75% of successful registrations (SR) and capture range of 18 mm for registrations of 3D to biplane 2D angiograms. In general, registration accuracy was similar whether registration of 3D image was performed onto mono- or biplanar 2D images; however, the SR was substantially lower in case of 3D to monoplane 2D registration. Two feature-based and two hybrid methods had clinically feasible execution times in the order of a second. Performance of methods seems to fall below expectations in terms of robustness in case of registration of 3D to monoplane 2D images, while translation into clinical image guidance systems seems readily feasible for methods that perform registration of the 3D pre-interventional image onto biplanar intra

Comparing morbidity and cancer control after 3D-conformal (70/74 Gy) and intensity modulated radiotherapy (78/82 Gy) for prostate cancer

International Nuclear Information System (INIS)

Dolezel, Martin; Odrazka, Karel; Zouhar, Milan; Jansa, Jan; Paluska, Petr; Vaculikova, Miloslava; Sefrova, Jana; Kohlova, Tereza; Vanasek, Jaroslav; Kovarik, Josef

2015-01-01

The purpose of this work was to compare toxicity and cancer control between patients with prostate cancer treated using three-dimensional conformal radiotherapy (3D-CRT) and those treated using intensity-modulated radiation therapy (IMRT). A total of 553 patients with prostate cancer were treated with 3D-CRT 70-74 Gy (3D-CRT 70, 3D-CRT 74) or IMRT 78-82 Gy (IMRT 78, IMRT/SIB 82). Late toxicity was scored according to FC-RTOG/LENT criteria. Biochemical failure was defined using the Phoenix and ASTRO definitions. The 5-year risk of grade 2-4 genitourinary toxicity was 26.3 % (3D-CRT 70), 27.2 % (3D-CRT 74), 17.3 % (IMRT 78), and 25.1 % (IMRT/SIB 82) without statistical differences. The 5-year risk of grade 2-4 gastrointestinal toxicity was 19.4 % (3D-CRT 70), 42.1 % (3D-CRT 74), 20.5 % (IMRT 78), and 26.6 % (IMRT/SIB 82). The differences between 3D-CRT 74 and 3D-CRT 70 and between 3D-CRT 74 and IMRT 78 were statistically significant (log rank p = 0.03). The 5-year Phoenix PSA relapse-free survival (PSA-RFS) in low-risk, intermediate-risk, and high-risk patients treated using 3D-CRT were 89.4, 65.5, and 57.8 %, respectively. Patients treated with IMRT achieved the following results: 90.9, 89.4, and 83.9 %. Clinical relapse-free survival (C-RFS) in patients treated using 3D-CRT vs. IMRT for the aforementioned groups were 94.7 vs. 100 %, 86.8 vs. 98.6 %, and 84.4 vs. 94.5 %. Disease-free survival (DFS) for patients treated using 3D-CRT were 83.1, 70.9, and 71.5 %. The IMRT group reached 95.8, 89.1, and 87.6 %. The PSA-RFS for intermediate- and high-risk patients were statistically significant, while C-RFS and DFS were marginally better. Dose escalation with IMRT was associated with improved cancer control in intermediate- and high-risk patients in comparison with 3D-CRT, without compromising toxicity. (orig.) [de

Evaluation of prospective motion correction of high-resolution 3D-T2-FLAIR acquisitions in epilepsy patients.

Science.gov (United States)

Vos, Sjoerd B; Micallef, Caroline; Barkhof, Frederik; Hill, Andrea; Winston, Gavin P; Ourselin, Sebastien; Duncan, John S

2018-03-02

T2-FLAIR is the single most sensitive MRI contrast to detect lesions underlying focal epilepsies but 3D sequences used to obtain isotropic high-resolution images are susceptible to motion artefacts. Prospective motion correction (PMC) - demonstrated to improve 3D-T1 image quality in a pediatric population - was applied to high-resolution 3D-T2-FLAIR scans in adult epilepsy patients to evaluate its clinical benefit. Coronal 3D-T2-FLAIR scans were acquired with a 1mm isotropic resolution on a 3T MRI scanner. Two expert neuroradiologists reviewed 40 scans without PMC and 40 with navigator-based PMC. Visual assessment addressed six criteria of image quality (resolution, SNR, WM-GM contrast, intensity homogeneity, lesion conspicuity, diagnostic confidence) on a seven-point Likert scale (from non-diagnostic to outstanding). SNR was also objectively quantified within the white matter. PMC scans had near-identical scores on the criteria of image quality to non-PMC scans, with the notable exception that intensity homogeneity was generally worse. Using PMC, the percentage of scans with bad image quality was substantially lower than without PMC (3.25% vs. 12.5%) on the other five criteria. Quantitative SNR estimates revealed that PMC and non-PMC had no significant difference in SNR (P=0.07). Application of prospective motion correction to 3D-T2-FLAIR sequences decreased the percentage of low-quality scans, reducing the number of scans that need to be repeated to obtain clinically useful data. Copyright © 2018 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Non-Thermal High-Intensity Focused Ultrasound for Breast Cancer Therapy

Science.gov (United States)

2013-07-01

Comet assay reveals DNA strand breaks induced by ultrasonic cavitation in vitro, Ultrasound in medicine & biology 1995; 21: 841-8. 3. Dalecki D...doxorubicin, focused ultrasound , HIFU, prostate cancer I. INTRODUCTION Pulsed high-intensity focused ultrasound (pFUS) is able to create acoustic cavitation ... ultrasound for breast cancer therapy PRINCIPAL INVESTIGATOR: Chang Ming (Charlie) Ma, Ph.D

Compact D-D/D-T neutron generators and their applications

International Nuclear Information System (INIS)

Lou, Tak Pui

2003-01-01

Neutron generators based on the 2 H(d,n) 3 He and 3 H(d,n) 4 He fusion reactions are the most commonly available neutron sources. The applications of current commercial neutron generators are often limited by their low neutron yield and their short operational lifetime. A new generation of D-D/D-T fusion-based neutron generators has been designed at Lawrence Berkeley National Laboratory (LBNL) by using high current ion beams hitting on a self-loading target that has a large surface area to dissipate the heat load. This thesis describes the rationale behind the new designs and their potential applications. A survey of other neutron sources is presented to show their advantages and disadvantages compared to the fusion-based neutron generator. A prototype neutron facility was built at LBNL to test these neutron generators. High current ion beams were extracted from an RF-driven ion source to produce neutrons. With an average deuteron beam current of 24 mA and an energy of 100 keV, a neutron yield of >10 9 n/s has been obtained with a D-D coaxial neutron source. Several potential applications were investigated by using computer simulations. The computer code used for simulations and the variance reduction techniques employed were discussed. A study was carried out to determine the neutron flux and resolution of a D-T neutron source in thermal neutron scattering applications for condensed matter experiments. An error analysis was performed to validate the scheme used to predict the resolution. With a D-T neutron yield of 10 14 n/s, the thermal neutron flux at the sample was predicted to be 7.3 x 10 5 n/cm 2 s. It was found that the resolution of cold neutrons was better than that of thermal neutrons when the duty factor is high. This neutron generator could be efficiently used for research and educational purposes at universities. Additional applications studied were positron production and Boron Neutron Capture Therapy (BNCT). The neutron flux required for positron

Can Supplementation of Vitamin D Improve Aerobic Capacity in Well Trained Youth Soccer Players?

Directory of Open Access Journals (Sweden)

Jastrzębska Maria

2018-03-01

Full Text Available There is no clear evidence that vitamin D effectively improves physical capacity in high-level athletes. The aim of this study was to confirm that vitamin D supplementation of soccer players during eight-week high-intensity training would have a significant effect on their aerobic capacity. The subjects were divided into two groups: the experimental one that was supplemented with vitamin D (SG, n = 20, and the placebo group (PG, n = 16, not supplemented with vitamin D. All the players were subjected to the same soccer training described as High-Intensity Interval Training (HIIT. The data of the vitamin D level, PWC170, lactate threshold (LT were collected just before and after the intervention. A significant increase in vitamin D concentration (119% was observed in the supplemented group, while the non-supplemented group showed a decrease of 8.4%. The studied subjects improved VO2max results by 20% in the SG, and by 13% in the PG. The improvement in velocity at the LT was similar in both groups. Results of this study show that vitamin D can have a positive, though moderate, effect on aerobic performance in players subjected to high-intensity training in the form of small-sided games for 8 weeks.

Motion robust high resolution 3D free-breathing pulmonary MRI using dynamic 3D image self-navigator.

Science.gov (United States)

Jiang, Wenwen; Ong, Frank; Johnson, Kevin M; Nagle, Scott K; Hope, Thomas A; Lustig, Michael; Larson, Peder E Z

2018-06-01

To achieve motion robust high resolution 3D free-breathing pulmonary MRI utilizing a novel dynamic 3D image navigator derived directly from imaging data. Five-minute free-breathing scans were acquired with a 3D ultrashort echo time (UTE) sequence with 1.25 mm isotropic resolution. From this data, dynamic 3D self-navigating images were reconstructed under locally low rank (LLR) constraints and used for motion compensation with one of two methods: a soft-gating technique to penalize the respiratory motion induced data inconsistency, and a respiratory motion-resolved technique to provide images of all respiratory motion states. Respiratory motion estimation derived from the proposed dynamic 3D self-navigator of 7.5 mm isotropic reconstruction resolution and a temporal resolution of 300 ms was successful for estimating complex respiratory motion patterns. This estimation improved image quality compared to respiratory belt and DC-based navigators. Respiratory motion compensation with soft-gating and respiratory motion-resolved techniques provided good image quality from highly undersampled data in volunteers and clinical patients. An optimized 3D UTE sequence combined with the proposed reconstruction methods can provide high-resolution motion robust pulmonary MRI. Feasibility was shown in patients who had irregular breathing patterns in which our approach could depict clinically relevant pulmonary pathologies. Magn Reson Med 79:2954-2967, 2018. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

Quasi 3D dosimetry (EPID, conventional 2D/3D detector matrices)

International Nuclear Information System (INIS)

Bäck, A

2015-01-01

Patient specific pretreatment measurement for IMRT and VMAT QA should preferably give information with a high resolution in 3D. The ability to distinguish complex treatment plans, i.e. treatment plans with a difference between measured and calculated dose distributions that exceeds a specified tolerance, puts high demands on the dosimetry system used for the pretreatment measurements and the results of the measurement evaluation needs a clinical interpretation. There are a number of commercial dosimetry systems designed for pretreatment IMRT QA measurements. 2D arrays such as MapCHECK ® (Sun Nuclear), MatriXX Evolution (IBA Dosimetry) and OCTAVIOUS ® 1500 (PTW), 3D phantoms such as OCTAVIUS ® 4D (PTW), ArcCHECK ® (Sun Nuclear) and Delta 4 (ScandiDos) and software for EPID dosimetry and 3D reconstruction of the dose in the patient geometry such as EPIDose TM (Sun Nuclear) and Dosimetry Check TM (Math Resolutions) are available. None of those dosimetry systems can measure the 3D dose distribution with a high resolution (full 3D dose distribution). Those systems can be called quasi 3D dosimetry systems. To be able to estimate the delivered dose in full 3D the user is dependent on a calculation algorithm in the software of the dosimetry system. All the vendors of the dosimetry systems mentioned above provide calculation algorithms to reconstruct a full 3D dose in the patient geometry. This enables analyzes of the difference between measured and calculated dose distributions in DVHs of the structures of clinical interest which facilitates the clinical interpretation and is a promising tool to be used for pretreatment IMRT QA measurements. However, independent validation studies on the accuracy of those algorithms are scarce. Pretreatment IMRT QA using the quasi 3D dosimetry systems mentioned above rely on both measurement uncertainty and accuracy of calculation algorithms. In this article, these quasi 3D dosimetry systems and their use in patient specific

Progressive attenuation fields: Fast 2D-3D image registration without precomputation

International Nuclear Information System (INIS)

Rohlfing, Torsten; Russakoff, Daniel B.; Denzler, Joachim; Mori, Kensaku; Maurer, Calvin R. Jr.

2005-01-01

Computation of digitally reconstructed radiograph (DRR) images is the rate-limiting step in most current intensity-based algorithms for the registration of three-dimensional (3D) images to two-dimensional (2D) projection images. This paper introduces and evaluates the progressive attenuation field (PAF), which is a new method to speed up DRR computation. A PAF is closely related to an attenuation field (AF). A major difference is that a PAF is constructed on the fly as the registration proceeds; it does not require any precomputation time, nor does it make any prior assumptions of the patient pose or limit the permissible range of patient motion. A PAF effectively acts as a cache memory for projection values once they are computed, rather than as a lookup table for precomputed projections like standard AFs. We use a cylindrical attenuation field parametrization, which is better suited for many medical applications of 2D-3D registration than the usual two-plane parametrization. The computed attenuation values are stored in a hash table for time-efficient storage and access. Using clinical gold-standard spine image data sets from five patients, we demonstrate consistent speedups of intensity-based 2D-3D image registration using PAF DRRs by a factor of 10 over conventional ray casting DRRs with no decrease of registration accuracy or robustness

Compact D-D/D-T neutron generators and their applications

Energy Technology Data Exchange (ETDEWEB)

Lou, Tak Pui [Univ. of California, Berkeley, CA (United States)

2003-01-01

Neutron generators based on the ²H(d,n)³He and ³H(d,n)⁴He fusion reactions are the most commonly available neutron sources. The applications of current commercial neutron generators are often limited by their low neutron yield and their short operational lifetime. A new generation of D-D/D-T fusion-based neutron generators has been designed at Lawrence Berkeley National Laboratory (LBNL) by using high current ion beams hitting on a self-loading target that has a large surface area to dissipate the heat load. This thesis describes the rationale behind the new designs and their potential applications. A survey of other neutron sources is presented to show their advantages and disadvantages compared to the fusion-based neutron generator. A prototype neutron facility was built at LBNL to test these neutron generators. High current ion beams were extracted from an RF-driven ion source to produce neutrons. With an average deuteron beam current of 24 mA and an energy of 100 keV, a neutron yield of >10⁹ n/s has been obtained with a D-D coaxial neutron source. Several potential applications were investigated by using computer simulations. The computer code used for simulations and the variance reduction techniques employed were discussed. A study was carried out to determine the neutron flux and resolution of a D-T neutron source in thermal neutron scattering applications for condensed matter experiments. An error analysis was performed to validate the scheme used to predict the resolution. With a D-T neutron yield of 10¹⁴ n/s, the thermal neutron flux at the sample was predicted to be 7.3 x 10⁵ n/cm²s. It was found that the resolution of cold neutrons was better than that of thermal neutrons when the duty factor is high. This neutron generator could be efficiently used for research and educational purposes at universities. Additional applications studied were positron production and

The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status

Directory of Open Access Journals (Sweden)

Ola Engelsen

2010-05-01

Full Text Available This paper reviews the main factors influencing the synthesis of vitamin D, with particular focus on ultraviolet radiation exposure. On the global level, the main source of vitamin D is the sun. The effect of solar radiation on vitamin D synthesis depends to some extent on the initial vitamin D levels. At moderate to high latitudes, diet becomes an increasingly important source of vitamin D due to decreased solar intensity and cold temperatures, which discourage skin exposure. During the mid-winter season, these factors result in decreased solar radiation exposure, hindering extensively the synthesis of vitamin D in these populations.

From 2D Lithography to 3D Patterning

NARCIS (Netherlands)

Van Zeijl, H.W.; Wei, J.; Shen, C.; Verhaar, T.M.; Sarro, P.M.

2010-01-01

Lithography as developed for IC device fabrication is a high volume high accuracy patterning technology with strong 2 dimensional (2D) characteristics. This 2D nature makes it a challenge to integrate this technology in a 3 dimensional (3D) manufacturing environment. This article addresses the

Growth of 2D and 3D plane cracks under thermo-mechanical loading with varying amplitudes

International Nuclear Information System (INIS)

Sbitti, Amine

2009-01-01

After a presentation of the phenomenon of thermal fatigue (in industrial applications and nuclear plants), this research thesis reports the investigation of the growth and arrest of a 2D crack under thermal fatigue (temperature and stress distribution over thickness, calculation of stress intensity factors, laws of fatigue crack growth, growth under varying amplitude), and the investigation of 3D crack growth under cyclic loading with varying amplitudes (analytic and numerical calculation of stress intensity factors, variational formulation in failure mechanics, 3D crack propagation under fatigue, use of the Aster code, use of the extended finite element method or X-FEM). The author discusses the origin and influence of the 3D crack network under thermal fatigue

Soft tubular microfluidics for 2D and 3D applications

Science.gov (United States)

Xi, Wang; Kong, Fang; Yeo, Joo Chuan; Yu, Longteng; Sonam, Surabhi; Dao, Ming; Gong, Xiaobo; Teck Lim, Chwee

2017-10-01

Microfluidics has been the key component for many applications, including biomedical devices, chemical processors, microactuators, and even wearable devices. This technology relies on soft lithography fabrication which requires cleanroom facilities. Although popular, this method is expensive and labor-intensive. Furthermore, current conventional microfluidic chips precludes reconfiguration, making reiterations in design very time-consuming and costly. To address these intrinsic drawbacks of microfabrication, we present an alternative solution for the rapid prototyping of microfluidic elements such as microtubes, valves, and pumps. In addition, we demonstrate how microtubes with channels of various lengths and cross-sections can be attached modularly into 2D and 3D microfluidic systems for functional applications. We introduce a facile method of fabricating elastomeric microtubes as the basic building blocks for microfluidic devices. These microtubes are transparent, biocompatible, highly deformable, and customizable to various sizes and cross-sectional geometries. By configuring the microtubes into deterministic geometry, we enable rapid, low-cost formation of microfluidic assemblies without compromising their precision and functionality. We demonstrate configurable 2D and 3D microfluidic systems for applications in different domains. These include microparticle sorting, microdroplet generation, biocatalytic micromotor, triboelectric sensor, and even wearable sensing. Our approach, termed soft tubular microfluidics, provides a simple, cheaper, and faster solution for users lacking proficiency and access to cleanroom facilities to design and rapidly construct microfluidic devices for their various applications and needs.

Variational 3D-PIV with sparse descriptors

Science.gov (United States)

Lasinger, Katrin; Vogel, Christoph; Pock, Thomas; Schindler, Konrad

2018-06-01

3D particle imaging velocimetry (3D-PIV) aims to recover the flow field in a volume of fluid, which has been seeded with tracer particles and observed from multiple camera viewpoints. The first step of 3D-PIV is to reconstruct the 3D locations of the tracer particles from synchronous views of the volume. We propose a new method for iterative particle reconstruction, in which the locations and intensities of all particles are inferred in one joint energy minimization. The energy function is designed to penalize deviations between the reconstructed 3D particles and the image evidence, while at the same time aiming for a sparse set of particles. We find that the new method, without any post-processing, achieves significantly cleaner particle volumes than a conventional, tomographic MART reconstruction, and can handle a wide range of particle densities. The second step of 3D-PIV is to then recover the dense motion field from two consecutive particle reconstructions. We propose a variational model, which makes it possible to directly include physical properties, such as incompressibility and viscosity, in the estimation of the motion field. To further exploit the sparse nature of the input data, we propose a novel, compact descriptor of the local particle layout. Hence, we avoid the memory-intensive storage of high-resolution intensity volumes. Our framework is generic and allows for a variety of different data costs (correlation measures) and regularizers. We quantitatively evaluate it with both the sum of squared differences and the normalized cross-correlation, respectively with both a hard and a soft version of the incompressibility constraint.

Nonlinear Delta-f Particle Simulations of Collective Effects in High-Intensity Bunched Beams

CERN Document Server

Qin, Hong; Hudson, Stuart R; Startsev, Edward

2005-01-01

The collective effects in high-intensity 3D bunched beams are described self-consistently by the nonlinear Vlasov-Maxwell equations.* The nonlinear delta-f method,** a particle simulation method for solving the nonlinear Vlasov-Maxwell equations, is being used to study the collective effects in high-intensity 3D bunched beams. The delta-f method, as a nonlinear perturbative scheme, splits the distribution function into equilibrium and perturbed parts. The perturbed distribution function is represented as a weighted summation over discrete particles, where the particle orbits are advanced by equations of motion in the focusing field and self-consistent fields, and the particle weights are advanced by the coupling between the perturbed fields and the zero-order distribution function. The nonlinear delta-f method exhibits minimal noise and accuracy problems in comparison with standard particle-in-cell simulations. A self-consistent 3D kinetic equilibrium is first established for high intensity bunched beams. The...

Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma

Energy Technology Data Exchange (ETDEWEB)

Yamazaki, Masahiro; Naganawa, Shinji; Kawai, Hisashi; Nihashi, Takashi [Nagoya University, Department of Radiology, Graduate School of Medicine, Nagoya (Japan); Fukatsu, Hiroshi [Aichi Medical University Hospital, Department of Medical Informatics, Nagakute (Japan); Nakashima, Tsutomu [Nagoya University, Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya (Japan)

2009-12-15

In the vestibular schwannoma patients, the pathophysiologic mechanism of inner ear involvement is still unclear. We investigated the status of the cochleae in patients with vestibular schwannoma by evaluating the signal intensity of cochlear fluid on pre- and post-contrast enhanced thin section three-dimensional fluid-attenuated inversion recovery (3D-FLAIR). Twenty-eight patients were retrospectively analyzed. Post-contrast images were obtained in 18 patients, and 20 patients had the records of their pure-tone audiometry. Regions of interest of both cochleae (C) and of the medulla oblongata (M) were determined on 3D-FLAIR images by referring to 3D heavily T2-weighted images on a workstation. The signal intensity ratio between C and M on the 3D-FLAIR images (CM ratio) was then evaluated. In addition, correlation between the CM ratio and the hearing level was also evaluated. The CM ratio of the affected side was significantly higher than that of the unaffected side (p < 0.001). In the affected side, post-contrast signal elevation was observed (p < 0.005). In 13 patients (26 cochleae) who underwent both gadolinium injection and the pure-tone audiometry, the post-contrast CM ratio correlated with hearing level (p < 0.05). The results of the present study suggest that alteration of cochlear fluid composition and increased permeability of the blood-labyrinthine barrier exist in the affected side in patients with vestibular schwannoma. Furthermore, although weak, positive correlation between post-contrast cochlear signal intensity on 3D-FLAIR and hearing level warrants further study to clarify the relationship between 3D-FLAIR findings and prognosis of hearing preservation surgery. (orig.)

Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma

International Nuclear Information System (INIS)

Yamazaki, Masahiro; Naganawa, Shinji; Kawai, Hisashi; Nihashi, Takashi; Fukatsu, Hiroshi; Nakashima, Tsutomu

2009-01-01

In the vestibular schwannoma patients, the pathophysiologic mechanism of inner ear involvement is still unclear. We investigated the status of the cochleae in patients with vestibular schwannoma by evaluating the signal intensity of cochlear fluid on pre- and post-contrast enhanced thin section three-dimensional fluid-attenuated inversion recovery (3D-FLAIR). Twenty-eight patients were retrospectively analyzed. Post-contrast images were obtained in 18 patients, and 20 patients had the records of their pure-tone audiometry. Regions of interest of both cochleae (C) and of the medulla oblongata (M) were determined on 3D-FLAIR images by referring to 3D heavily T2-weighted images on a workstation. The signal intensity ratio between C and M on the 3D-FLAIR images (CM ratio) was then evaluated. In addition, correlation between the CM ratio and the hearing level was also evaluated. The CM ratio of the affected side was significantly higher than that of the unaffected side (p < 0.001). In the affected side, post-contrast signal elevation was observed (p < 0.005). In 13 patients (26 cochleae) who underwent both gadolinium injection and the pure-tone audiometry, the post-contrast CM ratio correlated with hearing level (p < 0.05). The results of the present study suggest that alteration of cochlear fluid composition and increased permeability of the blood-labyrinthine barrier exist in the affected side in patients with vestibular schwannoma. Furthermore, although weak, positive correlation between post-contrast cochlear signal intensity on 3D-FLAIR and hearing level warrants further study to clarify the relationship between 3D-FLAIR findings and prognosis of hearing preservation surgery. (orig.)

A Handy Preterm Infant Incubator for Providing Intensive Care: Simulation, 3D Printed Prototype, and Evaluation.

Science.gov (United States)

Zaylaa, Amira J; Rashid, Mohamad; Shaib, Mounir; El Majzoub, Imad

2018-01-01

Preterm infants encounter an abrupt delivery before their complete maturity during the third trimester of pregnancy. Polls anticipate an increase in the rates of preterm infants for 2025, especially in middle- and low-income countries. Despite the abundance of intensive care methods for preterm infants, such as, but not limited to, commercial, transport, embrace warmer, radiant warmer, and Kangaroo Mother Care methods, they are either expensive, lack the most essential requirements or specifications, or lack the maternal-preterm bond. This drove us to carry this original research and innovative idea of developing a new 3D printed prototype of a Handy preterm infant incubator. We aim to provide the most indispensable intensive care with the lowest cost, to bestow low-income countries with the Handy incubator's care, preserve the maternal -preterm's bond, and diminish the rate of mortality. Biomedical features, electronics, and biocompatible materials were utilized. The design was simulated, the prototype was 3D printed, and the outcomes were tested and evaluated. Simulation results showed the best fit for the Handy incubator's components. Experimental results showed the 3D-printed prototype and the time elapsed to obtain it. Evaluation results revealed that the overall performance of Kangaroo Mother Care and the embrace warmer was 75 ± 1.4% and 66.7 ± 1.5%, respectively, while the overall performance of our Handy incubator was 91.7 ± 1.6%, thereby our cost-effective Handy incubator surpassed existing intensive care methods. The future step is associating the Handy incubator with more specifications and advancements.

Low impact plutonium glovebox D&D

Energy Technology Data Exchange (ETDEWEB)

Rose, R.W.

1995-12-31

A dilemma often encountered in decontamination and decommissioning operations is the lack of choice as to the location where the work is to be performed. Facility siting, laboratory location, and adjacent support areas were often determined based on criteria, which while appropriate at the time, are not always the most conducive to a D&D project. One must learn to adapt and cope with as found conditions. High priority research activities, which cannot be interrupted, may be occurring in adjacent non-radiological facilities in the immediate vicinity where highly contaminated materials must be handled in the course of a D&D operation. The execution of a project within such an environment involves a high level of coordination, cooperation, professionalism and flexibility among the project, the work force and the surrounding occupants. Simply moving occupants from the potentially affected area is not always an option and much consideration must be given in the selection of the D&D methodology to be employed and the processes to be implemented. Determining project boundaries and the ensuring that adjacent occupants are included in the planning/scheduling of specific operations which impact their work area are important in the development of the safety envelope. Such was the case in the recent D&D of 61 gloveboxes contaminated with plutonium and other transuranic nuclides at the Argonne National Laboratory-East site. The gloveboxes, which were used in Department of Energy research and development program activities over the past 30 years, were decontaminated to below transuranic waste criteria, size reduced, packaged and removed from Building 212 by Argonne National Laboratory personnel in conjunction with Nuclear Fuel Services, Inc. with essentially no impact to adjacent occupants.

First observations of $\\bar{B}_s^0\\to D^+D^-$, $D_s^+D^-$ and $D^0\\bar{D}^0$ decays

CERN Document Server

Aaij, R; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amerio, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bauer, Th; Bay, A; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Burducea, I; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Couturier, B; Cowan, G A; Craik, D; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Oyanguren Campos, M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Dogaru, M; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Elsby, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Furfaro, E; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Hill, D; Hoballah, M; Hombach, C; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jans, E; Jaton, P; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Leverington, B; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lohn, S; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Lucchesi, D; Luisier, J; Luo, H; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Maurice, E; Mazurov, A; McCarthy, J; McNulty, R; Mcnab, A; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Morello, M J; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Smith, M; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urner, D; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiechczynski, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

2013-01-01

First observations and measurements of the branching fractions of the $\\bar{B}_s^0\\to D^+D^-$, $\\bar{B}_s^0\\to D_s^+D^-$ and $\\bar{B}_s^0\\to D^0\\bar{D}^0$ decays are presented using $1.0$~fb$^{-1}$ of data collected by the LHCb experiment. These branching fractions are normalized to those of $\\bar{B}^0\\to D^+D^-$, $B^0\\to D_s^+D^-$ and $B^-\\to D^0D_s^-$, respectively. An excess of events consistent with the decay $\\bar{B}^0\\to D^0\\bar{D}^0$ is also seen, and its branching fraction is measured relative to that of $B^-\\to D^0D_s^-$. Improved measurements of the branching fractions ${\\cal{B}}(\\bar{B}_s^0\\to D_s^+D_s^-)$ and ${\\cal{B}}(B^-\\to D^0D_s^-)$ are reported, each relative to ${\\cal{B}}(B^0\\to D_s^+D^-)$. The ratios of branching fractions are \\begin{align*} {{\\cal{B}}(\\bar{B}_s^0\\to D^+D^-)\\over {\\cal{B}}(\\bar{B}^0\\to D^+D^-)} &= 1.08\\pm 0.20\\pm0.10, \

Characterization of 2D-C/C composite for application of very high temperature reactor

International Nuclear Information System (INIS)

Shibata, Taiju; Sumita, Junya; Kunimoto, Eiji; Sawa, Kazuhiro; Makita, Taiyo; Takagi, Takashi; Kim, W.J.; Jung, C.H.; Park, J.Y.

2010-01-01

For in-core components of VHTR (Very High Temperature Reactor), carbon fiber reinforced carbon matrix composite (C/C composite) is one of the major candidate materials. In this study, fracture behaviors of two dimensional (2D-) C/C composites were examined by SENB specimens with four-point bending test. The surface of specimens was observed by a CCD camera during the bending test, and observed by a stereomicroscope before and after the bending test. The following results were obtained through mode-I fracture test. (1) Three types of the composites were evaluated by tentatively using the stress intensity factor equation for metallic materials. The equivalent stress intensity factor of 2D-C/C composite is in the range of 5.9 - 10.0MPa m 1/2 . It was expected that the fracture mechanism for the composite materials could be assessed by this test method. (2) The crack opening displacement-load behavior of C/C composite might depend not only on the propagation of crack but also on delaminating between layers. (author)

Measurements of the internal magnetic field on DIII-D using intensity and spacing of the motional Stark multiplet.

Science.gov (United States)

Pablant, N A; Burrell, K H; Groebner, R J; Kaplan, D H; Holcomb, C T

2008-10-01

We describe a version of a motional Stark effect (MSE) diagnostic based on the relative line intensities and spacing of Stark split D(alpha) emission from the neutral beams. This system, named B-Stark, has been recently installed on the DIII-D tokamak. To find the magnetic pitch angle, we use the ratio of the intensities of the pi(3) and sigma(1) lines. These lines originate from the same upper level and so are not dependent on the level populations. In future devices, such as ITER, this technique may have advantages over diagnostics based on MSE polarimetry. We have done an optimization of the viewing direction for the available ports on DIII-D to choose the installation location. With this placement, we have a near optimal viewing angle of 59.6 degrees from the vertical direction. All hardware has been installed for one chord, and we have been routinely taking data since January 2007. We fit the spectra using a simple Stark model in which the upper level populations of the D(alpha) transition are treated as free variables. The magnitude and direction of the magnetic field obtained using this diagnostic technique compare well with measurements from MSE polarimetry and EFIT.

Fabrication of highly modulable fibrous 3D extracellular microenvironments

KAUST Repository

Zhang, Xixiang; Han, Fangfei; Syed, Ahad; Bukhari, Ebtihaj M.; Siang, Basil Chew Joo; Yang, Shan; Zhou, Bingpu; Wen, Wei-jia; Jiang, Dechen

2017-01-01

Three-dimensional (3D) in vitro scaffolds that mimic the irregular fibrous structures of in vivo extracellular matrix (ECM) are critical for many important biological applications. However, structural properties modulation of fibrous 3D scaffolds remains a challenge. Here, we report the first highly modulable 3D fibrous scaffolds self-assembled by high-aspect-ratio (HAR) microfibers. The scaffolds structural properties can be easily tailored to incorporate various physical cues, including geometry, stiffness, heterogeneity and nanotopography. Moreover, the fibrous scaffolds are readily and accurately patterned on desired locations of the substrate. Cell culture exhibits that our scaffolds can elicit strong bidirectional cell-material interactions. Furthermore, a functional disparity between the two-dimensional substrate and our 3D scaffolds is identified by cell spreading and proliferation data. These results prove the potential of the proposed scaffold as a biomimetic extracellular microenvironment for cell study.

Fabrication of highly modulable fibrous 3D extracellular microenvironments

KAUST Repository

Zhang, Xixiang

2017-06-13

Three-dimensional (3D) in vitro scaffolds that mimic the irregular fibrous structures of in vivo extracellular matrix (ECM) are critical for many important biological applications. However, structural properties modulation of fibrous 3D scaffolds remains a challenge. Here, we report the first highly modulable 3D fibrous scaffolds self-assembled by high-aspect-ratio (HAR) microfibers. The scaffolds structural properties can be easily tailored to incorporate various physical cues, including geometry, stiffness, heterogeneity and nanotopography. Moreover, the fibrous scaffolds are readily and accurately patterned on desired locations of the substrate. Cell culture exhibits that our scaffolds can elicit strong bidirectional cell-material interactions. Furthermore, a functional disparity between the two-dimensional substrate and our 3D scaffolds is identified by cell spreading and proliferation data. These results prove the potential of the proposed scaffold as a biomimetic extracellular microenvironment for cell study.

A case of high-titer anti-D hemolytic disease of the newborn in which late onset and mild course is associated with the D variant, RHD-CE(9)-D

DEFF Research Database (Denmark)

Jakobsen, Marianne A; Nielsen, Christian; Sprogøe, Ulrik

2014-01-01

BACKGROUND: The RhD antigen is very immunogenic and is a significant cause of hemolytic disease of the newborn (HDN). The RHD-CE(8-9)-D hybrid allele is commonly associated with a D- phenotype. Here, we report a case of high-titer maternal anti-D and late onset of HDN in a newborn carrying a RHD......-CE(9)-D variant supposedly encoding the same partial D antigen as the RHD-CE(8-9)-D allele, but with significant expression of D antigen. STUDY DESIGN AND METHODS: To elucidate the blood group antigen background of the case, we carried out serologic, flow cytometric, and genetics studies of the newborn...

Volumetric intensity dependence on the formation of molecular and atomic ions within a high intensity laser focus.

Science.gov (United States)

Robson, Lynne; Ledingham, Kenneth W D; McKenna, Paul; McCanny, Thomas; Shimizu, Seiji; Yang, Jiamin M; Wahlström, Claes-Göran; Lopez-Martens, Rodrigo; Varju, Katalin; Johnsson, Per; Mauritsson, Johan

2005-01-01

The mechanism of atomic and molecular ionization in intense, ultra-short laser fields is a subject which continues to receive considerable attention. An inherent difficulty with techniques involving the tight focus of a laser beam is the continuous distribution of intensities contained within the focus, which can vary over several orders of magnitude. The present study adopts time of flight mass spectrometry coupled with a high intensity (8 x 10(15) Wcm(-2)), ultra-short (20 fs) pulse laser in order to investigate the ionization and dissociation of the aromatic molecule benzene-d1 (C(6)H(5)D) as a function of intensity within a focused laser beam, by scanning the laser focus in the direction of propagation, while detecting ions produced only in a "thin" slice (400 and 800 microm) of the focus. The resultant TOF mass spectra varies significantly, highlighting the dependence on the range of specific intensities accessed and their volumetric weightings on the ionization/dissociation pathways accessed.

Development of high intensity proton accelerator

International Nuclear Information System (INIS)

Mizumoto, M.; Kusano, J.; Hasegawa, K.; Ouchi, N.; Oguri, H.; Kinsho, M.; Touchi, Y.; Honda, Y.; Mukugi, K.; Ino, H.; Noda, F.; Akaoka, N.; Kaneko, H.; Chishiro, E.; Fechner, B.

1997-01-01

The high-intensity proton linear accelerator with an energy of 1.5 GeV and an average current of 5.33mA has been proposed for the Neutron Science Project (NSP) at JAERI. the NSP is aiming at exploring nuclear technologies for nuclear waste transmutation based on a proton induced spallation neutrons. The proposed accelerators facilities will be also used in the various basic research fields such as condensed matter physics in combination with a high intensity proton storage ring. The R and D work has been carried out for the components of the front-end of the proton accelerator. For the high energy portion above 100 MeV, superconducting (SC) accelerator linac has been designed and developed as a major option. (Author) 7 refs

2D-3D registration for cranial radiation therapy using a 3D kV CBCT and a single limited field-of-view 2D kV radiograph.

Science.gov (United States)

Munbodh, Reshma; Knisely, Jonathan Ps; Jaffray, David A; Moseley, Douglas J

2018-05-01

We present and evaluate a fully automated 2D-3D intensity-based registration framework using a single limited field-of-view (FOV) 2D kV radiograph and a 3D kV CBCT for 3D estimation of patient setup errors during brain radiotherapy. We evaluated two similarity measures, the Pearson correlation coefficient on image intensity values (ICC) and maximum likelihood measure with Gaussian noise (MLG), derived from the statistics of transmission images. Pose determination experiments were conducted on 2D kV radiographs in the anterior-posterior (AP) and left lateral (LL) views and 3D kV CBCTs of an anthropomorphic head phantom. In order to minimize radiation exposure and exclude nonrigid structures from the registration, limited FOV 2D kV radiographs were employed. A spatial frequency band useful for the 2D-3D registration was identified from the bone-to-no-bone spectral ratio (BNBSR) of digitally reconstructed radiographs (DRRs) computed from the 3D kV planning CT of the phantom. The images being registered were filtered accordingly prior to computation of the similarity measures. We evaluated the registration accuracy achievable with a single 2D kV radiograph and with the registration results from the AP and LL views combined. We also compared the performance of the 2D-3D registration solutions proposed to that of a commercial 3D-3D registration algorithm, which used the entire skull for the registration. The ground truth was determined from markers affixed to the phantom and visible in the CBCT images. The accuracy of the 2D-3D registration solutions, as quantified by the root mean squared value of the target registration error (TRE) calculated over a radius of 3 cm for all poses tested, was ICC AP : 0.56 mm, MLG AP : 0.74 mm, ICC LL : 0.57 mm, MLG LL : 0.54 mm, ICC (AP and LL combined): 0.19 mm, and MLG (AP and LL combined): 0.21 mm. The accuracy of the 3D-3D registration algorithm was 0.27 mm. There was no significant difference in mean TRE for the 2D-3D registration

Fission multipliers for D-D/D-T neutron generators

International Nuclear Information System (INIS)

Lou, T.P.; Vujic, J.L.; Koivunoro, H.; Reijonen, J.; Leung, K.-N.

2003-01-01

A compact D-D/D-T fusion based neutron generator is being designed at the Lawrence Berkeley National Laboratory to have a potential yield of 10 12 D-D n/s and 10 14 D-T n/s. Because of its high neutron yield and compact size (∼20 cm in diameter by 4 cm long), this neutron generator design will be suitable for many applications. However, some applications required higher flux available from nuclear reactors and spallation neutron sources operated with GeV proton beams. In this study, a subcritical fission multiplier with k eff of 0.98 is coupled with the compact neutron generators in order to increase the neutron flux output. We have chosen two applications to show the gain in flux due to the use of fission multipliers--in-core irradiation and out-of-core irradiation. For the in-core irradiation, we have shown that a gain of ∼25 can be achieved in a positron production system using D-T generator. For the out-of-core irradiation, a gain of ∼17 times is obtained in Boron Neutron Capture Therapy (BNCT) using a D-D neutron generator. The total number of fission neutrons generated by a source neutron in a fission multiplier with k eff is ∼50. For the out-of-core irradiation, the theoretical maximum net multiplication is ∼30 due to the absorption of neutrons in the fuel. A discussion of the achievable multiplication and the theoretical multiplication will be presented in this paper

Highly Enhanced Many-Body Interactions in Anisotropic 2D Semiconductors.

Science.gov (United States)

Sharma, Ankur; Yan, Han; Zhang, Linglong; Sun, Xueqian; Liu, Boqing; Lu, Yuerui

2018-05-15

dynamics of excitons, trions, and biexcitons in reduced dimensions and fundamental many body interactions. We begin by explaining the fundamental reasons for the highly enhanced interactions in the 2D systems influenced by dielectric screening, resulting in high binding energies of excitons and trions, which are supported by theoretical calculations and experimental observations. Phosphorene has shown much higher binding energies of excitons and trions than TMD monolayers, which allows robust quasi-particles in anisotropic materials at room temperature. We also discuss the role of extrinsic defects induced in phosphorene, resulting in localized excitonic emissions in the near-infrared range, making it suitable for optical telecommunication applications. Finally, we present our vision of the exciting device applications based on the highly enhanced many body interactions in phosphorene, including exciton-polariton devices, polariton lasers, single-photon emitters, and tunable light emitting diodes (LEDs).

Reconstruction of incomplete cell paths through a 3D-2D level set segmentation

Science.gov (United States)

Hariri, Maia; Wan, Justin W. L.

2012-02-01

Segmentation of fluorescent cell images has been a popular technique for tracking live cells. One challenge of segmenting cells from fluorescence microscopy is that cells in fluorescent images frequently disappear. When the images are stacked together to form a 3D image volume, the disappearance of the cells leads to broken cell paths. In this paper, we present a segmentation method that can reconstruct incomplete cell paths. The key idea of this model is to perform 2D segmentation in a 3D framework. The 2D segmentation captures the cells that appear in the image slices while the 3D segmentation connects the broken cell paths. The formulation is similar to the Chan-Vese level set segmentation which detects edges by comparing the intensity value at each voxel with the mean intensity values inside and outside of the level set surface. Our model, however, performs the comparison on each 2D slice with the means calculated by the 2D projected contour. The resulting effect is to segment the cells on each image slice. Unlike segmentation on each image frame individually, these 2D contours together form the 3D level set function. By enforcing minimum mean curvature on the level set surface, our segmentation model is able to extend the cell contours right before (and after) the cell disappears (and reappears) into the gaps, eventually connecting the broken paths. We will present segmentation results of C2C12 cells in fluorescent images to illustrate the effectiveness of our model qualitatively and quantitatively by different numerical examples.

Signal alteration of the cochlear perilymph on 3 different sequences after intratympanic Gd-DTPA administration at 3 tesla. Comparison of 3D-FLAIR, 3D-T1-weighted imaging, and 3D-CISS

International Nuclear Information System (INIS)

Yamazaki, Masahiro; Naganawa, Shinji; Kawai, Hisashi; Nihashi, Takashi; Nakashima, Tsutomu

2010-01-01

Three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) imaging after intratympanic gadolinium injection is useful for pathophysiologic and morphologic analysis of the inner ear. However, statistical analysis of differences in inner ear signal intensity among 3D-FLAIR and other sequences has not been reported. We evaluated the signal intensity of cochlear fluid on each of 3D-FLAIR, 3D-T 1 -weighted imaging (T 1 WI), and 3D-constructive interference in the steady state (CISS) to clarify the differences in contrast effect among these 3 sequences using intratympanic gadolinium injection. Twenty-one patients underwent 3D-FLAIR, 3D-T 1 WI, and 3D-CISS imaging at 3 tesla 24 hours after intratympanic injection of gadolinium. We determined regions of interest of the cochleae (C) and medulla oblongata (M) on each image, evaluated the signal intensity ratio between C and M (CM ratio), and determined the ratio of cochlear signal intensity of the injected side to that of the non-injected side (contrast value). The CM ratio of the injected side (3.00±1.31, range, 0.53 to 4.88, on 3D-FLAIR; 0.83±0.30, range, 0.36 to 1.58 on 3D-T 1 WI) was significantly higher than that of the non-injected side (0.52±0.14, range, 0.30 to 0.76 on 3D-FLAIR; 0.49±0.11, range, 0.30 to 0.71 on 3D-T 1 WI) on 3D-FLAIR and 3D-T 1 WI (P 1 WI (1.73±0.60 range, 0.98 to 3.09) (P<0.001). The 3D-FLAIR sequence is the most sensitive for observing alteration in inner ear fluid signal after intratympanic gadolinium injection. Our results warrant use of 3D-FLAIR as a sensitive imaging technique to clarify the pathological and morphological mechanisms of disorders of the inner ear. (author)

FY 2000 report on the results of the R and D of femtosecond technology. R and D of high intensity X-ray pulse use power generation facility monitoring system; 2000 nendo femto byo technology no kenkyu kaihatsu seika hokokusho. Kokido X sen pulse riyo hatsuden shisetsu monitoring system no kenkyu kaihatsu

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

This project aims at creating new industrial basement technology which supports the highly information-oriented society in the 21st century, conducts the R and D of technology to control the state of light and electron in the femtosecond time domain (10{sup -15} - 10{sup -12} sec), and establishes the basement technology which exceeds the speed limit of the conventional electronics technology and also includes new functionality. Especially, in the R and D of the high intensity X-ray pulse use power generation facility monitoring system, the establishment is aimed at of the basement technology toward the realization of non-stop inspection of high speed moving objects of power generation facilities, etc. using femtosecond high intensity X-ray pulse generated in the interaction between femtosecond optical pulse and high density electron beam pulse. In this fiscal year, femtosecond X-ray was successfully generated. The pulse width of X-ray: 400fs, the wavelength: 6 angstroms, the X-ray dose generated in one collision: 10{sup 4} photons/pulse or more, and the energy of electron beam colliding with laser optical pulse: 12 MeV. Moreover, developed were the laser amplifying system and the stabilized high power femtosecond laser system. (NEDO)

Excitation-energy-dependent resonances in x-ray emissions under near-threshold electron excitation of the Ce 3d and 4d levels

International Nuclear Information System (INIS)

Chamberlain, M.B.; Baun, W.L.

1975-01-01

Soft x-ray appearance potential spectra of the 3d and 4d levels of polycrystalline cerium metal are reported in this paper. Resonant x-ray emissions are observed when the electron-excitation energy sweeps through the ionization energies of the 3d and 4d levels. The resonant x rays excited at the 3d-level onsets are considerably more intense, and are excited at a lower electron-excitation energy than the 3d-series characteristic x rays. In the neighborhood of the 4d-electron thresholds, four line-like structures extend to approx.8 eV below the 4d-electron binding energies, while two broad and more intense structures occur above the 4d onsets, with the largest one reaching a peak intensity at 12 eV above the 4d thresholds. The resonant emissions apparently arise from the decay of threshold-excited states which are bound to the inner vacancy and have core configurations nd 9 4f 3 , (n=3,4). The exchange interaction between the three 4f electrons and the respective d-orbital vacancy spreads the 4d-threshold structures over a 20 eV range of excitation energies and the 3d-threshold structures over a much smaller range

3D Rainbow Particle Tracking Velocimetry

Science.gov (United States)

Aguirre-Pablo, Andres A.; Xiong, Jinhui; Idoughi, Ramzi; Aljedaani, Abdulrahman B.; Dun, Xiong; Fu, Qiang; Thoroddsen, Sigurdur T.; Heidrich, Wolfgang

2017-11-01

A single color camera is used to reconstruct a 3D-3C velocity flow field. The camera is used to record the 2D (X,Y) position and colored scattered light intensity (Z) from white polyethylene tracer particles in a flow. The main advantage of using a color camera is the capability of combining different intensity levels for each color channel to obtain more depth levels. The illumination system consists of an LCD projector placed perpendicularly to the camera. Different intensity colored level gradients are projected onto the particles to encode the depth position (Z) information of each particle, benefiting from the possibility of varying the color profiles and projected frequencies up to 60 Hz. Chromatic aberrations and distortions are estimated and corrected using a 3D laser engraved calibration target. The camera-projector system characterization is presented considering size and depth position of the particles. The use of these components reduces dramatically the cost and complexity of traditional 3D-PTV systems.

3D visualization reduces operating time when compared to high-definition 2D in laparoscopic liver resection: a case-matched study.

Science.gov (United States)

Velayutham, Vimalraj; Fuks, David; Nomi, Takeo; Kawaguchi, Yoshikuni; Gayet, Brice

2016-01-01

To evaluate the effect of three-dimensional (3D) visualization on operative performance during elective laparoscopic liver resection (LLR). Major limitations of conventional laparoscopy are lack of depth perception and tactile feedback. Introduction of robotic technology, which employs 3D imaging, has removed only one of these technical obstacles. Despite the significant advantages claimed, 3D systems have not been widely accepted. In this single institutional study, 20 patients undergoing LLR by high-definition 3D laparoscope between April 2014 and August 2014 were matched to a retrospective control group of patients who underwent LLR by two-dimensional (2D) laparoscope. The number of patients who underwent major liver resection was 5 (25%) in the 3D group and 10 (25%) in the 2D group. There was no significant difference in contralateral wedge resection or combined resections between the 3D and 2D groups. There was no difference in the proportion of patients undergoing previous abdominal surgery (70 vs. 77%, p = 0.523) or previous hepatectomy (20 vs. 27.5%, p = 0.75). The operative time was significantly shorter in the 3D group when compared to 2D (225 ± 109 vs. 284 ± 71 min, p = 0.03). There was no significant difference in blood loss in the 3D group when compared to 2D group (204 ± 226 in 3D vs. 252 ± 349 ml in 2D group, p = 0.291). The major complication rates were similar, 5% (1/20) and 7.5% (3/40), respectively, (p ≥ 0.99). 3D visualization may reduce the operating time compared to high-definition 2D. Further large studies, preferably prospective randomized control trials are required to confirm this.

High current density 2D/3D MoS2/GaN Esaki tunnel diodes

Science.gov (United States)

Krishnamoorthy, Sriram; Lee, Edwin W.; Lee, Choong Hee; Zhang, Yuewei; McCulloch, William D.; Johnson, Jared M.; Hwang, Jinwoo; Wu, Yiying; Rajan, Siddharth

2016-10-01

The integration of two-dimensional materials such as transition metal dichalcogenides with bulk semiconductors offer interesting opportunities for 2D/3D heterojunction-based device structures without any constraints of lattice matching. By exploiting the favorable band alignment at the GaN/MoS2 heterojunction, an Esaki interband tunnel diode is demonstrated by transferring large area Nb-doped, p-type MoS2 onto heavily n-doped GaN. A peak current density of 446 A/cm2 with repeatable room temperature negative differential resistance, peak to valley current ratio of 1.2, and minimal hysteresis was measured in the MoS2/GaN non-epitaxial tunnel diode. A high current density of 1 kA/cm2 was measured in the Zener mode (reverse bias) at -1 V bias. The GaN/MoS2 tunnel junction was also modeled by treating MoS2 as a bulk semiconductor, and the electrostatics at the 2D/3D interface was found to be crucial in explaining the experimentally observed device characteristics.

Benefits From R and D For D and D Projects Preparation

International Nuclear Information System (INIS)

Georges, Christine; Boucher, Lionel; Charton, Frederic; Soulabaille, Yves

2016-01-01

CEA (French Alternative Energies and Atomic Energy Commission) is both the operator of important nuclear facilities all over the nuclear cycle, in charge of major new built or Decommissioning and Dismantling (D and D) projects and a R and D group with dynamic policy of technology transfer. The position of CEA in D and D is unique because of the number and the wide diversity of facilities under decommissioning, with some high level of contamination. Innovative solutions are being developed in 6 main axes to protect the operators, to minimize the overall costs and the volumes of waste, especially used when preparing D and D operations: Investigations in the facilities, Radiological measurement of waste, Technologies for hostile environment, Decontamination of soils and structures, Waste treatment and conditioning and Methods and Information Technology (IT) Tools for project and waste management. The last developments are shown and examples of industrial applications given. CEA is willing to share actions in partnership with other operators or with industrials dealing with the same problems to solve. (authors)

A D-D neutron generator using a titanium drive-in target

International Nuclear Information System (INIS)

Kim, I.J.; Jung, N.S.; Jung, H.D.; Hwang, Y.S.; Choi, H.D.

2008-01-01

A D-D neutron generator was developed with an intensity of 10 8 n/s. A helicon plasma ion source was used to produce a large current deuteron beam, and neutrons were generated by irradiating the deuteron beam on a titanium drive-in target made of commercial pure titanium. The neutron generator was test-run for several hundred hours, and the performances were investigated. The available range of the deuteron beam current was 0.8-8 mA and the beam could be accelerated up to 97.5 keV. The maximum neutron generation rate in the test-runs was 1.9 x 10 8 n/s, which was achieved by irradiating a 7.6 mA deuteron beam at 94.0 keV on a 0.5 mm-thick target. The operation of the neutron generator was fairly stable, such that the neutron generation rate was not altered by high voltage breakdowns during the test-runs. Neutron generation efficiency was rated as low as 10% when compared to an ideal case of irradiating a 100% monatomic deuteron beam on a perfect TiD 2 target. Factors causing the low efficiency were suggested and discussed

Validation of a 4D-PET Maximum Intensity Projection for Delineation of an Internal Target Volume

International Nuclear Information System (INIS)

Callahan, Jason; Kron, Tomas; Schneider-Kolsky, Michal; Dunn, Leon; Thompson, Mick; Siva, Shankar; Aarons, Yolanda; Binns, David; Hicks, Rodney J.

2013-01-01

Purpose: The delineation of internal target volumes (ITVs) in radiation therapy of lung tumors is currently performed by use of either free-breathing (FB) 18 F-fluorodeoxyglucose-positron emission tomography-computed tomography (FDG-PET/CT) or 4-dimensional (4D)-CT maximum intensity projection (MIP). In this report we validate the use of 4D-PET-MIP for the delineation of target volumes in both a phantom and in patients. Methods and Materials: A phantom with 3 hollow spheres was prepared surrounded by air then water. The spheres and water background were filled with a mixture of 18 F and radiographic contrast medium. A 4D-PET/CT scan was performed of the phantom while moving in 4 different breathing patterns using a programmable motion device. Nine patients with an FDG-avid lung tumor who underwent FB and 4D-PET/CT and >5 mm of tumor motion were included for analysis. The 3 spheres and patient lesions were contoured by 2 contouring methods (40% of maximum and PET edge) on the FB-PET, FB-CT, 4D-PET, 4D-PET-MIP, and 4D-CT-MIP. The concordance between the different contoured volumes was calculated using a Dice coefficient (DC). The difference in lung tumor volumes between FB-PET and 4D-PET volumes was also measured. Results: The average DC in the phantom using 40% and PET edge, respectively, was lowest for FB-PET/CT (DCAir = 0.72/0.67, DCBackground 0.63/0.62) and highest for 4D-PET/CT-MIP (DCAir = 0.84/0.83, DCBackground = 0.78/0.73). The average DC in the 9 patients using 40% and PET edge, respectively, was also lowest for FB-PET/CT (DC = 0.45/0.44) and highest for 4D-PET/CT-MIP (DC = 0.72/0.73). In the 9 lesions, the target volumes of the FB-PET using 40% and PET edge, respectively, were on average 40% and 45% smaller than the 4D-PET-MIP. Conclusion: A 4D-PET-MIP produces volumes with the highest concordance with 4D-CT-MIP across multiple breathing patterns and lesion sizes in both a phantom and among patients. Freebreathing PET/CT consistently underestimates ITV

Validation of a 4D-PET Maximum Intensity Projection for Delineation of an Internal Target Volume

Energy Technology Data Exchange (ETDEWEB)

Callahan, Jason, E-mail: jason.callahan@petermac.org [Centre for Molecular Imaging, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Kron, Tomas [Department of Physical Sciences, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne (Australia); Schneider-Kolsky, Michal [Department of Medical Imaging and Radiation Science, Monash University, Clayton, Victoria (Australia); Dunn, Leon [Department of Applied Physics, RMIT University, Melbourne (Australia); Thompson, Mick [Centre for Molecular Imaging, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Siva, Shankar [Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Aarons, Yolanda [Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne (Australia); Binns, David [Centre for Molecular Imaging, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Hicks, Rodney J. [Centre for Molecular Imaging, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne (Australia)

2013-07-15

Purpose: The delineation of internal target volumes (ITVs) in radiation therapy of lung tumors is currently performed by use of either free-breathing (FB) {sup 18}F-fluorodeoxyglucose-positron emission tomography-computed tomography (FDG-PET/CT) or 4-dimensional (4D)-CT maximum intensity projection (MIP). In this report we validate the use of 4D-PET-MIP for the delineation of target volumes in both a phantom and in patients. Methods and Materials: A phantom with 3 hollow spheres was prepared surrounded by air then water. The spheres and water background were filled with a mixture of {sup 18}F and radiographic contrast medium. A 4D-PET/CT scan was performed of the phantom while moving in 4 different breathing patterns using a programmable motion device. Nine patients with an FDG-avid lung tumor who underwent FB and 4D-PET/CT and >5 mm of tumor motion were included for analysis. The 3 spheres and patient lesions were contoured by 2 contouring methods (40% of maximum and PET edge) on the FB-PET, FB-CT, 4D-PET, 4D-PET-MIP, and 4D-CT-MIP. The concordance between the different contoured volumes was calculated using a Dice coefficient (DC). The difference in lung tumor volumes between FB-PET and 4D-PET volumes was also measured. Results: The average DC in the phantom using 40% and PET edge, respectively, was lowest for FB-PET/CT (DCAir = 0.72/0.67, DCBackground 0.63/0.62) and highest for 4D-PET/CT-MIP (DCAir = 0.84/0.83, DCBackground = 0.78/0.73). The average DC in the 9 patients using 40% and PET edge, respectively, was also lowest for FB-PET/CT (DC = 0.45/0.44) and highest for 4D-PET/CT-MIP (DC = 0.72/0.73). In the 9 lesions, the target volumes of the FB-PET using 40% and PET edge, respectively, were on average 40% and 45% smaller than the 4D-PET-MIP. Conclusion: A 4D-PET-MIP produces volumes with the highest concordance with 4D-CT-MIP across multiple breathing patterns and lesion sizes in both a phantom and among patients. Freebreathing PET/CT consistently

R&D ADMINISTRATION IN THE HIGH TECHNOLOGY INDUSTRY: HOW TO MANAGE A PARADOX

Directory of Open Access Journals (Sweden)

Nobuiuki Costa Ito

2010-10-01

Full Text Available The competitive environment of the knowledge age is getting more complex, dynamic, and fast-moving each day. The high tech industry is intensively tied to its effects and demands for innovation, so the field of Research and Development must act strategically, generating innovations and granting success and sustainability to the business. However, there is a paradox in R&D which may lay traps and obstacles disguised by the busy day-to-day activity of the organization. The purpose of this paper is to point out directions that managers may take to cope with these contradictions in R&D administration. The R&D paradox is rooted in the conflict between exploitation, achieved by continual improvement through incremental innovation, and by exploration, which seeks new opportunities in the creation of new technologies through disruptive innovations. These two sides of the paradox demand different, and sometimes even divergent, organizations. Top management leadership is crucial for the acceptance and balancing of the contradictions created by this paradox, and can align exploitation/exploration through distributive and integrative decisions and transform companies into truly ambidextrous organizations.    Key-words:  Research & Development. Innovation. Paradox. Ambidextrous organizations. Strategy. 

Dosimetric and Radiobiologic Comparison of 3D Conformal Versus Intensity Modulated Planning Techniques for Prostate Bed Radiotherapy

International Nuclear Information System (INIS)

Koontz, Bridget F.; Das, Shiva; Temple, Kathy; Bynum, Sigrun; Catalano, Suzanne; Koontz, Jason I.; Montana, Gustavo S.; Oleson, James R.

2009-01-01

Adjuvant radiotherapy for locally advanced prostate cancer improves biochemical and clinical disease-free survival. While comparisons in intact prostate cancer show a benefit for intensity modulated radiation therapy (IMRT) over 3D conformal planning, this has not been studied for post-prostatectomy radiotherapy (RT). This study compares normal tissue and target dosimetry and radiobiological modeling of IMRT vs. 3D conformal planning in the postoperative setting. 3D conformal plans were designed for 15 patients who had been treated with IMRT planning for salvage post-prostatectomy RT. The same computed tomography (CT) and target/normal structure contours, as well as prescription dose, was used for both IMRT and 3D plans. Normal tissue complication probabilities (NTCPs) were calculated based on the dose given to the bladder and rectum by both plans. Dose-volume histogram and NTCP data were compared by paired t-test. Bladder and rectal sparing were improved with IMRT planning compared to 3D conformal planning. The volume of the bladder receiving at least 75% (V75) and 50% (V50) of the dose was significantly reduced by 28% and 17%, respectively (p = 0.002 and 0.037). Rectal dose was similarly reduced, V75 by 33% and V50 by 17% (p = 0.001 and 0.004). While there was no difference in the volume of rectum receiving at least 65 Gy (V65), IMRT planning significant reduced the volume receiving 40 Gy or more (V40, p = 0.009). Bladder V40 and V65 were not significantly different between planning modalities. Despite these dosimetric differences, there was no significant difference in the NTCP for either bladder or rectal injury. IMRT planning reduces the volume of bladder and rectum receiving high doses during post-prostatectomy RT. Because of relatively low doses given to the bladder and rectum, there was no statistically significant improvement in NTCP between the 3D conformal and IMRT plans.

Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy.

Science.gov (United States)

Koontz, Bridget F; Das, Shiva; Temple, Kathy; Bynum, Sigrun; Catalano, Suzanne; Koontz, Jason I; Montana, Gustavo S; Oleson, James R

2009-01-01

Adjuvant radiotherapy for locally advanced prostate cancer improves biochemical and clinical disease-free survival. While comparisons in intact prostate cancer show a benefit for intensity modulated radiation therapy (IMRT) over 3D conformal planning, this has not been studied for post-prostatectomy radiotherapy (RT). This study compares normal tissue and target dosimetry and radiobiological modeling of IMRT vs. 3D conformal planning in the postoperative setting. 3D conformal plans were designed for 15 patients who had been treated with IMRT planning for salvage post-prostatectomy RT. The same computed tomography (CT) and target/normal structure contours, as well as prescription dose, was used for both IMRT and 3D plans. Normal tissue complication probabilities (NTCPs) were calculated based on the dose given to the bladder and rectum by both plans. Dose-volume histogram and NTCP data were compared by paired t-test. Bladder and rectal sparing were improved with IMRT planning compared to 3D conformal planning. The volume of the bladder receiving at least 75% (V75) and 50% (V50) of the dose was significantly reduced by 28% and 17%, respectively (p = 0.002 and 0.037). Rectal dose was similarly reduced, V75 by 33% and V50 by 17% (p = 0.001 and 0.004). While there was no difference in the volume of rectum receiving at least 65 Gy (V65), IMRT planning significant reduced the volume receiving 40 Gy or more (V40, p = 0.009). Bladder V40 and V65 were not significantly different between planning modalities. Despite these dosimetric differences, there was no significant difference in the NTCP for either bladder or rectal injury. IMRT planning reduces the volume of bladder and rectum receiving high doses during post-prostatectomy RT. Because of relatively low doses given to the bladder and rectum, there was no statistically significant improvement in NTCP between the 3D conformal and IMRT plans.

A high-frequency transimpedance amplifier for CMOS integrated 2D CMUT array towards 3D ultrasound imaging.

Science.gov (United States)

Huang, Xiwei; Cheong, Jia Hao; Cha, Hyouk-Kyu; Yu, Hongbin; Je, Minkyu; Yu, Hao

2013-01-01

One transimpedance amplifier based CMOS analog front-end (AFE) receiver is integrated with capacitive micromachined ultrasound transducers (CMUTs) towards high frequency 3D ultrasound imaging. Considering device specifications from CMUTs, the TIA is designed to amplify received signals from 17.5MHz to 52.5MHz with center frequency at 35MHz; and is fabricated in Global Foundry 0.18-µm 30-V high-voltage (HV) Bipolar/CMOS/DMOS (BCD) process. The measurement results show that the TIA with power-supply 6V can reach transimpedance gain of 61dBΩ and operating frequency from 17.5MHz to 100MHz. The measured input referred noise is 27.5pA/√Hz. Acoustic pulse-echo testing is conducted to demonstrate the receiving functionality of the designed 3D ultrasound imaging system.

Fast multi-core based multimodal registration of 2D cross-sections and 3D datasets.

Science.gov (United States)

Scharfe, Michael; Pielot, Rainer; Schreiber, Falk

2010-01-11

Solving bioinformatics tasks often requires extensive computational power. Recent trends in processor architecture combine multiple cores into a single chip to improve overall performance. The Cell Broadband Engine (CBE), a heterogeneous multi-core processor, provides power-efficient and cost-effective high-performance computing. One application area is image analysis and visualisation, in particular registration of 2D cross-sections into 3D image datasets. Such techniques can be used to put different image modalities into spatial correspondence, for example, 2D images of histological cuts into morphological 3D frameworks. We evaluate the CBE-driven PlayStation 3 as a high performance, cost-effective computing platform by adapting a multimodal alignment procedure to several characteristic hardware properties. The optimisations are based on partitioning, vectorisation, branch reducing and loop unrolling techniques with special attention to 32-bit multiplies and limited local storage on the computing units. We show how a typical image analysis and visualisation problem, the multimodal registration of 2D cross-sections and 3D datasets, benefits from the multi-core based implementation of the alignment algorithm. We discuss several CBE-based optimisation methods and compare our results to standard solutions. More information and the source code are available from http://cbe.ipk-gatersleben.de. The results demonstrate that the CBE processor in a PlayStation 3 accelerates computational intensive multimodal registration, which is of great importance in biological/medical image processing. The PlayStation 3 as a low cost CBE-based platform offers an efficient option to conventional hardware to solve computational problems in image processing and bioinformatics.

Comparative study of the interaction of meso-tetrakis (N-para-trimethyl-anilium) porphyrin (TMAP) in its free base and Fe derivative form with oligo(dA.dT)15 and oligo(dG.dC)15.

Science.gov (United States)

Bathaie, S Zahra; Ajloo, Davood; Daraie, Marzieh; Ghadamgahi, Maryam

2015-01-01

Interaction between a cationic porphyrin and its ferric derivative with oligo(dA.dT)15 and oligo(dG.dC)15 was studied by UV-vis spectroscopy, resonance light scattering (RLS), and circular dichroism (CD) at different ionic strengths; molecular docking and molecular dynamics simulation were also used for completion. Followings are the observed changes in the spectral properties of meso-tetrakis (N-para-trimethyl-anilium) porphyrin (TMAP), as a free-base porphyrin with no axial ligand, and its Fe derivative (FeTMAP) upon interaction with oligo(dA.dT)15 and oligo(dG.dC)15: (1) the substantial red shift and hypochromicity at the Soret maximum in the UV-vis spectra; (2) the increased RLS intensity by increasing the ionic strength; and (3) an intense bisignate excitonic CD signal. All of them are the reasons for TMAP and FeTMAP binding to oligo(dA.dT)15 and oligo(dG.dC)15 with the outside binding mode, accompanied by the self-stacking of the ligands along the oligonucleotide helix. The CD results demonstrated a drastic change from excitonic in monomeric behavior at higher ionic strengths, which indicates the groove binding of the ligands with oligonucleotides. Molecular docking also confirmed the groove binding mode of the ligands and estimated the binding constants and energies of the interactions. Their interaction trend was further confirmed by molecular dynamics technique and structure parameters obtained from simulation. It showed that TMAP reduced the number of intermolecular hydrogen bonds and increased the solvent accessible surface area in the oligonucleotide. The self-aggregation of ligands at lower concentrations was also confirmed.

D and D Knowledge Management Information Tool - 2012 - 12106

Energy Technology Data Exchange (ETDEWEB)

Upadhyay, H.; Lagos, L.; Quintero, W.; Shoffner, P. [Applied Research Center, Florida International University, Miami. FL 33174 (United States); DeGregory, J. [Office of D and D and Facility Engineering, Environmental Management, Department of Energy (United States)

2012-07-01

Deactivation and decommissioning (D and D) work is a high priority activity across the Department of Energy (DOE) complex. Subject matter specialists (SMS) associated with the different ALARA (As-Low-As-Reasonably-Achievable) Centers, DOE sites, Energy Facility Contractors Group (EFCOG) and the D and D community have gained extensive knowledge and experience over the years in the cleanup of the legacy waste from the Manhattan Project. To prevent the D and D knowledge and expertise from being lost over time from the evolving and aging workforce, DOE and the Applied Research Center (ARC) at Florida International University (FIU) proposed to capture and maintain this valuable information in a universally available and easily usable system. D and D KM-IT provides single point access to all D and D related activities through its knowledge base. It is a community driven system. D and D KM-IT makes D and D knowledge available to the people who need it at the time they need it and in a readily usable format. It uses the World Wide Web as the primary source for content in addition to information collected from subject matter specialists and the D and D community. It brings information in real time through web based custom search processes and its dynamic knowledge repository. Future developments include developing a document library, providing D and D information access on mobile devices for the Technology module and Hotline, and coordinating multiple subject matter specialists to support the Hotline. The goal is to deploy a high-end sophisticated and secured system to serve as a single large knowledge base for all the D and D activities. The system consolidates a large amount of information available on the web and presents it to users in the simplest way possible. (authors)

SU-D-BRA-03: Analysis of Systematic Errors with 2D/3D Image Registration for Target Localization and Treatment Delivery in Stereotactic Radiosurgery

International Nuclear Information System (INIS)

Xu, H; Chetty, I; Wen, N

2016-01-01

Purpose: Determine systematic deviations between 2D/3D and 3D/3D image registrations with six degrees of freedom (6DOF) for various imaging modalities and registration algorithms on the Varian Edge Linac. Methods: The 6DOF systematic errors were assessed by comparing automated 2D/3D (kV/MV vs. CT) with 3D/3D (CBCT vs. CT) image registrations from different imaging pairs, CT slice thicknesses, couch angles, similarity measures, etc., using a Rando head and a pelvic phantom. The 2D/3D image registration accuracy was evaluated at different treatment sites (intra-cranial and extra-cranial) by statistically analyzing 2D/3D pre-treatment verification against 3D/3D localization of 192 Stereotactic Radiosurgery/Stereotactic Body Radiation Therapy treatment fractions for 88 patients. Results: The systematic errors of 2D/3D image registration using kV-kV, MV-kV and MV-MV image pairs using 0.8 mm slice thickness CT images were within 0.3 mm and 0.3° for translations and rotations with a 95% confidence interval (CI). No significant difference between 2D/3D and 3D/3D image registrations (P>0.05) was observed for target localization at various CT slice thicknesses ranging from 0.8 to 3 mm. Couch angles (30, 45, 60 degree) did not impact the accuracy of 2D/3D image registration. Using pattern intensity with content image filtering was recommended for 2D/3D image registration to achieve the best accuracy. For the patient study, translational error was within 2 mm and rotational error was within 0.6 degrees in terms of 95% CI for 2D/3D image registration. For intra-cranial sites, means and std. deviations of translational errors were −0.2±0.7, 0.04±0.5, 0.1±0.4 mm for LNG, LAT, VRT directions, respectively. For extra-cranial sites, means and std. deviations of translational errors were - 0.04±1, 0.2±1, 0.1±1 mm for LNG, LAT, VRT directions, respectively. 2D/3D image registration uncertainties for intra-cranial and extra-cranial sites were comparable. Conclusion: The Varian

SU-D-BRA-03: Analysis of Systematic Errors with 2D/3D Image Registration for Target Localization and Treatment Delivery in Stereotactic Radiosurgery

Energy Technology Data Exchange (ETDEWEB)

Xu, H [Wayne State University, Detroit, MI (United States); Chetty, I; Wen, N [Henry Ford Health System, Detroit, MI (United States)

2016-06-15

Purpose: Determine systematic deviations between 2D/3D and 3D/3D image registrations with six degrees of freedom (6DOF) for various imaging modalities and registration algorithms on the Varian Edge Linac. Methods: The 6DOF systematic errors were assessed by comparing automated 2D/3D (kV/MV vs. CT) with 3D/3D (CBCT vs. CT) image registrations from different imaging pairs, CT slice thicknesses, couch angles, similarity measures, etc., using a Rando head and a pelvic phantom. The 2D/3D image registration accuracy was evaluated at different treatment sites (intra-cranial and extra-cranial) by statistically analyzing 2D/3D pre-treatment verification against 3D/3D localization of 192 Stereotactic Radiosurgery/Stereotactic Body Radiation Therapy treatment fractions for 88 patients. Results: The systematic errors of 2D/3D image registration using kV-kV, MV-kV and MV-MV image pairs using 0.8 mm slice thickness CT images were within 0.3 mm and 0.3° for translations and rotations with a 95% confidence interval (CI). No significant difference between 2D/3D and 3D/3D image registrations (P>0.05) was observed for target localization at various CT slice thicknesses ranging from 0.8 to 3 mm. Couch angles (30, 45, 60 degree) did not impact the accuracy of 2D/3D image registration. Using pattern intensity with content image filtering was recommended for 2D/3D image registration to achieve the best accuracy. For the patient study, translational error was within 2 mm and rotational error was within 0.6 degrees in terms of 95% CI for 2D/3D image registration. For intra-cranial sites, means and std. deviations of translational errors were −0.2±0.7, 0.04±0.5, 0.1±0.4 mm for LNG, LAT, VRT directions, respectively. For extra-cranial sites, means and std. deviations of translational errors were - 0.04±1, 0.2±1, 0.1±1 mm for LNG, LAT, VRT directions, respectively. 2D/3D image registration uncertainties for intra-cranial and extra-cranial sites were comparable. Conclusion: The Varian

Collection efficiency of charges in ionization chambers in presence of constant or variable radiation intensity; Efficacite de la collection des charges dans les chambres d'ionisation en presence d'une intensite de rayonnement ionisant constante ou variable

Energy Technology Data Exchange (ETDEWEB)

Decuyper, J [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1970-07-01

The theoretical and experimental study of the collection of carriers built up by ionization in standard chambers, is made by varying the value of different acting parameters. In the presence of constant ionization intensity and under a D.C. and A.C. voltage, the effect of geometry, recombination, diffusion and attachment is analyzed. The compensation of thermal neutron D.C. chambers is equally considered. Under a time dependent ionization intensity and D.C. voltage, is then studied the effect of recombination on current response, and on the collection efficiency of all formed charges. (author) [French] L'etude theorique et experimentale de la collection des porteurs crees par ionisation dans les chambres couramment utilisees est entreprise en fonction de la valeur des differents parametres agissants. En presence d'une ionisation constante et sous une tension d'alimentation d'abord continue puis alternative, on analyse l'influence de la geometrie, de la recombinaison, de la diffusion et de l'attachement. La compensation des chambres a courant continu de mesure neutronique est egalement examinee. Ensuite, sous une intensite d'ionisation variable dans le temps et en alimentation continue, on etudie l'effet de la recombinaison sur la reponse en courant et sur l'efficacite de la collection de la charge totale liberee. (auteur)

A facile route for 3D aerogels from nanostructured 1D and 2D materials

Science.gov (United States)

Jung, Sung Mi; Jung, Hyun Young; Dresselhaus, Mildred S.; Jung, Yung Joon; Kong, Jing

2012-01-01

Aerogels have numerous applications due to their high surface area and low densities. However, creating aerogels from a large variety of materials has remained an outstanding challenge. Here, we report a new methodology to enable aerogel production with a wide range of materials. The method is based on the assembly of anisotropic nano-objects (one-dimensional (1D) nanotubes, nanowires, or two-dimensional (2D) nanosheets) into a cross-linking network from their colloidal suspensions at the transition from the semi-dilute to the isotropic concentrated regime. The resultant aerogels have highly porous and ultrafine three-dimensional (3D) networks consisting of 1D (Ag, Si, MnO2, single-walled carbon nanotubes (SWNTs)) and 2D materials (MoS2, graphene, h-BN) with high surface areas, low densities, and high electrical conductivities. This method opens up a facile route for aerogel production with a wide variety of materials and tremendous opportunities for bio-scaffold, energy storage, thermoelectric, catalysis, and hydrogen storage applications. PMID:23152940

Thermally stable cellulose nanocrystals toward high-performance 2D and 3D nanostructures

Science.gov (United States)

Chao Jia; Huiyang Bian; Tingting Gao; Feng Jiang; Iain Michael Kierzewski; Yilin Wang; Yonggang Yao; Liheng Chen; Ziqiang Shao; J. Y. Zhu; Liangbing Hu

2017-01-01

Cellulose nanomaterials have attracted much attention in a broad range of fields such as flexible electronics, tissue engineering, and 3D printing for their excellent mechanical strength and intriguing optical properties. Economic, sustainable, and eco-friendly production of cellulose nanomaterials with high thermal stability, however, remains a tremendous challenge....

Experimental subcritical facility driven by D-D/D-T neutron generator at BARC, India

Energy Technology Data Exchange (ETDEWEB)

Sinha, Amar, E-mail: image@barc.gov.in; Roy, Tushar; Kashyap, Yogesh; Ray, Nirmal; Shukla, Mayank; Patel, Tarun; Bajpai, Shefali; Sarkar, P.S.; Bishnoi, Saroj

2015-05-01

Highlights: •Experimental subcritical facility BRAHMMA coupled to D-D/D-T neutron generator. •Preliminary results of PNS experiments reported. •Feynman-alpha noise measurements explored with continuous source. -- Abstract: The paper presents design of an experimental subcritical assembly driven by D-D/D-T neutron and preliminary experimental measurements. The system has been developed for investigating the static and dynamic neutronic properties of accelerator driven sub-critical systems. This system is modular in design and it is first in the series of subcritical assemblies being designed. The subcritical core consists of natural uranium fuel with high density polyethylene as moderator and beryllium oxide as reflector. The fuel is embedded in high density polyethylene moderator matrix. Estimated k{sub eff} of the system is ∼0.89. One of the unique features of subcritical core is the use of Beryllium oxide (BeO) as reflector and HDPE as moderator making the assembly a compact modular system. The subcritical core is coupled to Purnima Neutron Generator which works in D-D and D-T mode with both DC and pulsed operation. It has facility for online source strength monitoring using neutron tagging and programmable source modulation. Preliminary experiments have been carried out for spatial flux measurement and reactivity estimation using pulsed neutron source (PNS) techniques with D-D neutrons. Further experiments are being planned to measure the reactivity and other kinetic parameters using noise methods. This facility would also be used for carrying out studies on effect of source importance and measurement of source multiplication factor k{sub s} and external neutron source efficiency φ{sup ∗} in great details. Experiments with D-T neutrons are also underway.

High-Intensity Interval Training for Improving Postprandial Hyperglycemia

Science.gov (United States)

Little, Jonathan P.; Francois, Monique E.

2014-01-01

High-intensity interval training (HIIT) has garnered attention in recent years as a time-efficient exercise option for improving cardiovascular and metabolic health. New research demonstrates that HIIT may be particularly effective for improving postprandial hyperglycemia in individuals with, or at risk for, type 2 diabetes (T2D). These findings…

Export performance and investment in R&D

DEFF Research Database (Denmark)

Smith, Valdemar; Madsen, Erik Strøjer; Dilling-Hansen, Mogens

2002-01-01

This paper analyses the role of R&D in the export behaviour of Danish firms. Export behaviour is defined as the export intensity and the likelihood of a firm being an exporter. In the theoretical part of the paper it is argued that export and being R&D active are endogenous with respect to each...... other, and an empirical model is formulated in order to estimate which factors affect the firm's export. It is argued that besides R&D, firm size, wages and a number of other firm-specific factors controlling for risks are highly important for the export performance. In the empirical part of the paper...... the model is tested on a sample of 3,500 Danish firms. Using a FIML estimation form in order to deal with endogeneity problems between the R&D and export decisions of the firms, the computation clearly verifies the theoretical model put forward. Moreover, R&D is an important factor for being an exporting...

Do R&D Investments Affect Export Performance?

DEFF Research Database (Denmark)

Smith, Valdemar; Madsen, Erik Strøjer; Dilling-Hansen, Mogens

2002-01-01

This paper analyses the role of R&D in the export behaviour of Danish firms. Export behaviour is defined as the export intensity and the likelihood of a firm being an exporter. In the theoretical part of the paper it is argued that export and being R&D active are endogenous with respect to each...... other, and an empirical model is formulated in order to estimate which factors affect the firm's export. It is argued that besides R&D, firm size, wages and a number of other firm-specific factors controlling for risks are highly important for the export performance. In the empirical part of the paper...... the model is tested on a sample of 3,500 Danish firms. Using a FIML estimation form in order to deal with endogeneity problems between the R&D and export decisions of the firms, the computation clearly verifies the theoretical model put forward. Moreover, R&D is an important factor for being an exporting...

New recommendations for vitamin D intake

Directory of Open Access Journals (Sweden)

Evgen Benedik

2013-10-01

Full Text Available Vitamin D is a fat-soluble vitamin that plays an important role in bone metabolism and immune system. Low vitamin D levels (< 50 nmol/l have been widely reported in all age groups in recent years. Lack of vitamin D is associated with increased overall and cardiovascular mortality, cancer incidence and mortality, and autoimmune diseases. Vitamin D deficiency is rising, mainly due to modern lifestyle and malabsorption disorders. As an adequate intake of vitamin D is hard to achieve through the diet alone, the dietary supplements of vitamin D are recommended. Sun exposure (ultraviolet B radiation, UVB represents the main source of vitamin D, which is synthesised in the skin. UVB intensity varies through the year and the time of day. The peak UVB period is between 10 am to 4 pm from April till October (above 40° latitude. There is no universal consent on the amount and frequency of vitamin D supplementation. A sufficient supplementation of vitamin D is necessary through the whole life cycle, especially during lactation. With sufficient supplementation of vitamin D during lactation (4,000 IU/day mother covers her own and through her breast milk also the child`s nutritional needs (400 IU/day for vitamin D. However, further research in this field is needed before recommending such a high supplementation for nursing mothers. New German Reference values from 2012 advises 400 IU / day for infants during the first year of life, and afterwards 800 IU/day for the entire population.

TIPS bilateral noise reduction in 4D CT perfusion scans produces high-quality cerebral blood flow maps

Energy Technology Data Exchange (ETDEWEB)

Mendrik, Adrienne M; Van Ginneken, Bram; Viergever, Max A [Image Sciences Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht (Netherlands); Vonken, Evert-jan; De Jong, Hugo W; Riordan, Alan; Van Seeters, Tom; Smit, Ewoud J; Prokop, Mathias, E-mail: a.m.mendrik@gmail.com [Radiology Department, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht (Netherlands)

2011-07-07

Cerebral computed tomography perfusion (CTP) scans are acquired to detect areas of abnormal perfusion in patients with cerebrovascular diseases. These 4D CTP scans consist of multiple sequential 3D CT scans over time. Therefore, to reduce radiation exposure to the patient, the amount of x-ray radiation that can be used per sequential scan is limited, which results in a high level of noise. To detect areas of abnormal perfusion, perfusion parameters are derived from the CTP data, such as the cerebral blood flow (CBF). Algorithms to determine perfusion parameters, especially singular value decomposition, are very sensitive to noise. Therefore, noise reduction is an important preprocessing step for CTP analysis. In this paper, we propose a time-intensity profile similarity (TIPS) bilateral filter to reduce noise in 4D CTP scans, while preserving the time-intensity profiles (fourth dimension) that are essential for determining the perfusion parameters. The proposed TIPS bilateral filter is compared to standard Gaussian filtering, and 4D and 3D (applied separately to each sequential scan) bilateral filtering on both phantom and patient data. Results on the phantom data show that the TIPS bilateral filter is best able to approach the ground truth (noise-free phantom), compared to the other filtering methods (lowest root mean square error). An observer study is performed using CBF maps derived from fifteen CTP scans of acute stroke patients filtered with standard Gaussian, 3D, 4D and TIPS bilateral filtering. These CBF maps were blindly presented to two observers that indicated which map they preferred for (1) gray/white matter differentiation, (2) detectability of infarcted area and (3) overall image quality. Based on these results, the TIPS bilateral filter ranked best and its CBF maps were scored to have the best overall image quality in 100% of the cases by both observers. Furthermore, quantitative CBF and cerebral blood volume values in both the phantom and the

Population database on: D1S1656, D2S441, D2S1338, D3S1358, D8S1179, D10S1248, D22S1045, D12S391, D16S539, D18S51, D19S433, D21S11, FGA, TH01, vWA loci included in NGM system based on one thousand unrelated individuals from Lodz region of Central Poland

Directory of Open Access Journals (Sweden)

Renata Jacewicz

2017-01-01

Full Text Available A population data obtained on the basis of sample of 1000 unrelated individuals of Polish ancestry living in Lodz region of Central Poland with use of fluorescent multiplex-PCR and capillary electrophoresis were presented. Evaluation included 15 polymorphic loci DNA – STR from NGM multiplex-PCR set, ie. D1S1656, D2S441, D2S1338, D3S1358, D8S1179, D10S1248, D12S391, D16S539, D18S51, D19S433, D21S11, D22S1045, FGA, TH01, vWA. The allele frequency distribution and crucial statistical parameters for the investigated markers and the whole set were calculated. The compliance of the studied population with Hardy-Weinberg equilibrium, independence of inheritance and high parameters of the usefulness in forensic genetics have been demonstrated. The interpopulation comparison performed by the „neighbor-joining” method as well as multidimensional scaling depicted the genetic distances dividing the examined Polish population from other populations of Poland, Europe and the world.

Alfven wave stability in D-III-D

International Nuclear Information System (INIS)

Campbell, R.B.; Samec, T.K.

1989-09-01

Within the framework of the global Alfven eigenmode theory in a cylindrical background plasma, I examine the excitation of global Alfven eigenmodes by intense neutral beam injection in the D III-D tokamak operating at General Atomics. I have considered two separate sets of experimental conditions, a ''low power'' set of cases using 10MW of hydrogen beams, and a ''high power'' shot of 20MW of deuterium beams. My results are particularly sensitive to the background density profile. For parabolic background density profiles, n 0 x (1 - (r/a) 2 ), I have determined that the plasma is stable to all toroidal and poloidal mode numbers for both high and low power cases. For density profiles which are of the form n 0 x (1 - (r/a) 2 ) 1/2 , for the same n 0 , my calculation indicates that the m = -1, l = 0 mode is unstable in each case. The high power case has a considerably higher growth rate at the baseline conditions, which motivated me to study this case more extensively. The results are also sensitive to the beam source radial scalelength, L s , and the electron temperature T e . By narrowing the source from the baseline 36 cm to 20 cm, the growth rate of the (0,-1) actually decreases, but the (0,-2) mode appears with a substantial growth rate. If the source could be made even narrower, L s ∼ 10 cm, the (1,-1) mode would appear, also with a large growth rate. 12 refs., 16 figs., 6 tabs

Targeted 2D/3D registration using ray normalization and a hybrid optimizer

International Nuclear Information System (INIS)

Dey, Joyoni; Napel, Sandy

2006-01-01

X-ray images are often used to guide minimally invasive procedures in interventional radiology. The use of a preoperatively obtained 3D volume can enhance the visualization needed for guiding catheters and other surgical devices. However, for intraoperative usefulness, the 3D dataset needs to be registered to the 2D x-ray images of the patient. We investigated the effect of targeting subvolumes of interest in the 3D datasets and registering the projections with C-arm x-ray images. We developed an intensity-based 2D/3D rigid-body registration using a Monte Carlo-based hybrid algorithm as the optimizer, using a single view for registration. Pattern intensity (PI) and mutual information (MI) were two metrics tested. We used normalization of the rays to address the problems due to truncation in 3D necessary for targeting. We tested the algorithm on a C-arm x-ray image of a pig's head and a 3D dataset reconstructed from multiple views of the C-arm. PI and MI were comparable in performance. For two subvolumes starting with a set of initial poses from +/-15 mm in x, from +/-3 mm (random), in y and z and +/-4 deg in the three angles, the robustness was 94% for PI and 91% for MI, with accuracy of 2.4 mm (PI) and 2.6 mm (MI), using the hybrid algorithm. The hybrid optimizer, when compared with a standard Powell's direction set method, increased the robustness from 59% (Powell) to 94% (hybrid). Another set of 50 random initial conditions from [+/-20] mm in x,y,z and [+/-10] deg in the three angles, yielded robustness of 84% (hybrid) versus 38% (Powell) using PI as metric, with accuracies 2.1 mm (hybrid) versus 2.0 mm (Powell)

Solution structure of d-GAATTCGAATTC by 2D NMR

International Nuclear Information System (INIS)

Hosur, R.V.; Ravikumar, M.; Chary, K.V.R.; Sheth, A.; Govil, G.

1986-01-01

A new approach based on the correlated spectroscopy (COSY) in 2D NMR has been described for determination of sugar geometries in oligonucleotides. Under the usual low resolution conditions employed in COSY, the intensities of cross peaks depend on the magnitudes of coupling constants. There are five vicinal coupling constants in a deoxyribose ring which are sensitive to the sugar geometry. The presence, absence and rough comparison of relative intensities of COSY cross peaks arising from such coupling constants enable one to fix the sugar conformation to a fair degree of precision. The methodology has been applied to d-GAATTCGAATTC. It is observed that ten out of the twelve nucleotide units in this sequence exhibit a rare O1'-endo geometry. The EcoRI cleavage sites in the dodecanucleotide show an interesting variation in the conformation with the two sugars attached to the Gs acquiring a geometry between C2'-endo and C4'-endo. (Auth.)

Modélisation du champ magnétique d'un propulseur M.H.D. annulaire

Science.gov (United States)

Kom, C. H.; Brunet, Y.

1995-01-01

Stray fields have to be as small as possible to reduce the magnetic signature of the vessel in M.H.D. propulsion where the magnetic field has to be very high. The calculation of the magnetic field of an angular M.H.D. thruster is presented. The field is produced by a distribution of superconducting magnets in the shape of sectors. An analytical formulation of the field can be used in the active zone, outside the coil ends. An analytical method using a Fourier development of the current sheets is employed for an inductor in cylindrical sectors, and a direct method is used for a massive inductor. Numerical and analytical results are compared. Pour des raisons de discrétion, les champs de fuite doivent être minimisés en propulsion M.H.D. où les champs magnétiques doivent être intenses. Le calcul du champ magnétique d'un propulseur M.H.D. naval annulaire, constitué de secteurs inducteurs supraconducteurs est représenté. Dans la zone active, hors des têtes de bobines, une formulation analytique peut être utilisée. Une méthode analytique utilisant le développemment en série de Fourier du courant est adoptée pour les industeurs cylindriques, et une méthode directe pour les inducteurs massifs. Les résultats numériques sont comparés à ceux obtenus avec un logiciel d'éléments finis 2D.

Initial-state-radiation production of D{sub s} Mesons and high precision measurements of D{sub s}1(2536) at Babar

Energy Technology Data Exchange (ETDEWEB)

Roney, Michael [Stanford Linear Accelerator Center - SLAC, National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025-7015 (United States); Izen, Joseph Michael [University of Texas at Dallas, Department of Physics, EC 36, 800 West Campbell Road, Richardson, Texas 75080-3021 (United States)

2010-07-01

A search for charmonium and other new states is performed in a study of exclusive initial-state-radiation production of D{sub s}{sup +}D{sub s}{sup -}, D{sub s}{sup *+}D{sub s}{sup -}, and D{sub s}{sup *+}D{sub s}{sup *-} events from electron-positron annihilations at a center-of-mass energy of 10.58 GeV. The data sample corresponds to an integrated luminosity of 525 fb{sup -1} recorded by the BaBar experiment at the PEP-II storage ring. We also study the decay width and the mass of the D{sub s}1(2536) meson with high precision via the decay channel D{sub s}1(2536){yields}D{sup +*} K{sup 0}{sub s} using 384 fb{sup -1} of data recorded by the BABAR experiment. (author)

JANUS reactor d and d project

International Nuclear Information System (INIS)

Fellhauer, C. R.

1998-01-01

Argonne National Laboratory (ANL-E) has recently completed the decontamination and decommissioning (D and D) of the JANUS Reactor Facility located in Building 202. The 200 KW reactor operated from August 1963 to March 1992. The facility was used to study the effects of both high and low doses of fission neutrons in animals. There were two exposure rooms on opposite sides of the reactor and the reactor was therefore named after the two-faced Roman god. The High Dose Room was capable of specimen exposure at a dose rate of 3,600 rads per hour. During calendar year 1996 a detailed characterization of the facility was performed by ANL-E Health Physics personnel. ANL-E Analytical Services performed the required sample analysis. An Auditable Safety Analysis and an Environmental Assessment were completed. D and D plans, procedures and procurement documents were prepared and approved. A D and D subcontractor was selected and a firm, fixed price contract awarded for the field work and final survey effort. The D and D subcontractor was mobilized to ANL-E in January 1997. Electrical isolation of all reactor equipment and control panels was accomplished and the equipment removed. A total of 207,230 pounds (94,082 Kg) of lead shielding was removed, surveyed and sampled, and free-released for recycle. All primary and secondary piping was removed, size reduced and packaged for disposal or recycled as appropriate. The reactor vessel was removed, sized reduced and packaged as radioactive waste in April. The activated graphite block reflector was removed next, followed by the bioshield concrete and steel. All of this material was packaged as low level waste. Total low level radioactive waste generation was 4002.1 cubic feet (113.3 cubic meters). Mixed waste generation was 538 cubic feet (15.2 cubic meters). The Final Release Survey was completed in September. The project field work was completed in 38 weeks without any lost-time accidents, personnel contaminations or unplanned

Low impact plutonium glovebox D ampersand D

International Nuclear Information System (INIS)

Rose, R.W.

1995-01-01

A dilemma often encountered in decontamination and decommissioning operations is the lack of choice as to the location where the work is to be performed. Facility siting, laboratory location, and adjacent support areas were often determined based on criteria, which while appropriate at the time, are not always the most conducive to a D ampersand D project. One must learn to adapt and cope with as found conditions. High priority research activities, which cannot be interrupted, may be occurring in adjacent non-radiological facilities in the immediate vicinity where highly contaminated materials must be handled in the course of a D ampersand D operation. The execution of a project within such an environment involves a high level of coordination, cooperation, professionalism and flexibility among the project, the work force and the surrounding occupants. Simply moving occupants from the potentially affected area is not always an option and much consideration must be given in the selection of the D ampersand D methodology to be employed and the processes to be implemented. Determining project boundaries and the ensuring that adjacent occupants are included in the planning/scheduling of specific operations which impact their work area are important in the development of the safety envelope. Such was the case in the recent D ampersand D of 61 gloveboxes contaminated with plutonium and other transuranic nuclides at the Argonne National Laboratory-East site. The gloveboxes, which were used in Department of Energy research and development program activities over the past 30 years, were decontaminated to below transuranic waste criteria, size reduced, packaged and removed from Building 212 by Argonne National Laboratory personnel in conjunction with Nuclear Fuel Services, Inc. with essentially no impact to adjacent occupants

Raman D-band in the irradiated graphene: Origin of the non-monotonous dependence of its intensity with defect concentration

International Nuclear Information System (INIS)

Codorniu Pujals, Daniel

2013-01-01

Raman spectroscopy is one of the most used experimental techniques in studying irradiated carbon nanostructures, in particular graphene, due to its high sensibility to the presence of defects in the crystalline lattice. Special attention has been given to the variation of the intensity of the Raman D-band of graphene with the concentration of defects produced by irradiation. Nowadays, there are enough experimental evidences about the non-monotonous character of that dependence, but the explanation of this behavior is still controversial. In the present work we developed a simplified mathematical model to obtain a functional relationship between these two magnitudes and showed that the non-monotonous dependence is intrinsic to the nature of the D-band and that it is not necessarily linked to amorphization processes. The obtained functional dependence was used to fit experimental data taken from other authors. The determination coefficient of the fitting was 0.96.

Recording stereoscopic 3D neurosurgery with a head-mounted 3D camera system.

Science.gov (United States)

Lee, Brian; Chen, Brian R; Chen, Beverly B; Lu, James Y; Giannotta, Steven L

2015-06-01

Stereoscopic three-dimensional (3D) imaging can present more information to the viewer and further enhance the learning experience over traditional two-dimensional (2D) video. Most 3D surgical videos are recorded from the operating microscope and only feature the crux, or the most important part of the surgery, leaving out other crucial parts of surgery including the opening, approach, and closing of the surgical site. In addition, many other surgeries including complex spine, trauma, and intensive care unit procedures are also rarely recorded. We describe and share our experience with a commercially available head-mounted stereoscopic 3D camera system to obtain stereoscopic 3D recordings of these seldom recorded aspects of neurosurgery. The strengths and limitations of using the GoPro(®) 3D system as a head-mounted stereoscopic 3D camera system in the operating room are reviewed in detail. Over the past several years, we have recorded in stereoscopic 3D over 50 cranial and spinal surgeries and created a library for education purposes. We have found the head-mounted stereoscopic 3D camera system to be a valuable asset to supplement 3D footage from a 3D microscope. We expect that these comprehensive 3D surgical videos will become an important facet of resident education and ultimately lead to improved patient care.

3D MODELLING OF PROPHYLACTIC FOOTWEAR FOR A HIGH ARCHED FOOT

OpenAIRE

COSTEA Mariana; MIHAI Aura

2016-01-01

This article approaches the methodology of designing customized footwear for high arched foot. The authors propose to reconsider the classical structure of footwear bottom components for people with high arched foot and recommend incorporating custom components, with the role of compensation or adjustment. This study continues the authors’ research, starting from a foot’s 3D shape obtained by 3D scanning, the anthropometrical and biomechanical parameters, shoe lasts’ 3D modelling and continui...

2D and 3D high resolution seismic imaging of shallow Solfatara crater in Campi Flegrei (Italy): new insights on deep hydrothermal fluid circulation processes

Science.gov (United States)

De Landro, Grazia; Gammaldi, Sergio; Serlenga, Vincenzo; Amoroso, Ortensia; Russo, Guido; Festa, Gaetano; D'Auria, Luca; Bruno, Pier Paolo; Gresse, Marceau; Vandemeulebrouck, Jean; Zollo, Aldo

2017-04-01

Seismic tomography can be used to image the spatial variation of rock properties within complex geological media such as volcanoes. Solfatara is a volcano located within the Campi Flegrei still active caldera, characterized by periodic episodes of extended, low-rate ground subsidence and uplift called bradyseism accompanied by intense seismic and geochemical activities. In particular, Solfatara is characterized by an impressive magnitude diffuse degassing, which underlines the relevance of fluid and heat transport at the crater and prompted further research to improve the understanding of the hydrothermal system feeding the surface phenomenon. In this line, an active seismic experiment, Repeated Induced Earthquake and Noise (RICEN) (EU Project MEDSUV), was carried out between September 2013 and November 2014 to provide time-varying high-resolution images of the structure of Solfatara. In this study we used the datasets provided by two different acquisition geometries: a) A 2D array cover an area of 90 x 115 m ^ 2 sampled by a regular grid of 240 vertical sensors deployed at the crater surface; b) two 1D orthogonal seismic arrays deployed along NE-SW and NW-SE directions crossing the 400 m crater surface. The arrays are sampled with a regular line of 240 receiver and 116 shots. We present 2D and 3D tomographic high-resolution P-wave velocity images obtained using two different tomographic methods adopting a multiscale strategy. The 3D image of the shallow (30-35 m) central part of Solfatara crater is performed through the iterative, linearized, tomographic inversion of the P-wave first arrival times. 2D P-wave velocity sections (60-70 m) are obtained using a non-linear travel-time tomography method based on the evaluation of a posteriori probability density with a Bayesian approach. The 3D retrieved images integrated with resistivity section and temperature and CO2 flux measurements , define the following characteristics: 1. A depth dependent P-wave velocity layer

Fast multi-core based multimodal registration of 2D cross-sections and 3D datasets

Directory of Open Access Journals (Sweden)

Pielot Rainer

2010-01-01

Full Text Available Abstract Background Solving bioinformatics tasks often requires extensive computational power. Recent trends in processor architecture combine multiple cores into a single chip to improve overall performance. The Cell Broadband Engine (CBE, a heterogeneous multi-core processor, provides power-efficient and cost-effective high-performance computing. One application area is image analysis and visualisation, in particular registration of 2D cross-sections into 3D image datasets. Such techniques can be used to put different image modalities into spatial correspondence, for example, 2D images of histological cuts into morphological 3D frameworks. Results We evaluate the CBE-driven PlayStation 3 as a high performance, cost-effective computing platform by adapting a multimodal alignment procedure to several characteristic hardware properties. The optimisations are based on partitioning, vectorisation, branch reducing and loop unrolling techniques with special attention to 32-bit multiplies and limited local storage on the computing units. We show how a typical image analysis and visualisation problem, the multimodal registration of 2D cross-sections and 3D datasets, benefits from the multi-core based implementation of the alignment algorithm. We discuss several CBE-based optimisation methods and compare our results to standard solutions. More information and the source code are available from http://cbe.ipk-gatersleben.de. Conclusions The results demonstrate that the CBE processor in a PlayStation 3 accelerates computational intensive multimodal registration, which is of great importance in biological/medical image processing. The PlayStation 3 as a low cost CBE-based platform offers an efficient option to conventional hardware to solve computational problems in image processing and bioinformatics.

The neutron small-angle camera D11 at the high-flux reactor, Grenoble

International Nuclear Information System (INIS)

Ibel, K.

1976-01-01

The neutron small-angle scattering system at the high-flux reactor in Grenoble consists of three major parts: the supply of cold neutrons via bent neutron guides; the small-angle camera D11; and the data handling facilities. The camera D11 has an overall length of 80 m. The effective length of the camera is variable. The full length of the collimator before the fixed sample position can be reduced by movable neutron guides; the second flight path of 40 m full length contains detector sites in various positions. Thus a large range of momentum transfers can be used with the same relative resolution. Scattering angles between 5 x 10 -4 and 0.5 rad and neutron wavelengths from 0.2 to 2.0 nm are available. A large-area position-sensitive detector is used which allows simultaneous recording of intensities scattered at different angles; it is a multiwire proportional chamber. 3808 elements of 1 cm 2 are arranged in a two-dimensional matrix. (Auth.)

L-edge sum rule analysis on 3d transition metal sites: from d10 to d0 and towards application to extremely dilute metallo-enzymes.

Science.gov (United States)

Wang, Hongxin; Friedrich, Stephan; Li, Lei; Mao, Ziliang; Ge, Pinghua; Balasubramanian, Mahalingam; Patil, Daulat S

2018-03-28

According to L-edge sum rules, the number of 3d vacancies at a transition metal site is directly proportional to the integrated intensity of the L-edge X-ray absorption spectrum (XAS) for the corresponding metal complex. In this study, the numbers of 3d holes are characterized quantitatively or semi-quantitatively for a series of manganese (Mn) and nickel (Ni) complexes, including the electron configurations 3d 10 → 3d 0 . In addition, extremely dilute (edge jump region; and (2) by adding an inert tracer to the sample that provides a prominent spectral feature to replace the weak edge jump for intensity normalization. In this publication, we present for the first time: (1) L-edge sum rule analysis for a series of Mn and Ni complexes that include electron configurations from an open shell 3d 0 to a closed shell 3d 10 ; (2) a systematic analysis on the uncertainties, especially on that from the edge jump, which was missing in all previous reports; (3) a clearly-resolved edge jump between pre-L 3 and post-L 2 regions from an extremely dilute sample; (4) an evaluation of an alternative normalization standard for L-edge sum rule analysis. XAS from two copper (Cu) proteins measured using a conventional semiconductor X-ray detector are also repeated as bridges between Ni complexes and dilute Ni enzymes. The differences between measuring 1% Cu enzymes and measuring edge sum rule analysis to virtually any 3d metal complex and any dilute biological samples that contain 3d metals.

Modélisation du champ magnétique d'un propulseur M.H.D. annulaire

OpenAIRE

Kom , C.; Brunet , Y.

1995-01-01

Pour des raisons de discrétion, les champs de fuite doivent être minimisés en propulsion M.H.D. où les champs magnétiques doivent être intenses. Le calcul du champ magnétique d'un propulseur M.H.D. naval annulaire, constitué de secteurs inducteurs supraconducteurs est représenté. Dans la zone active, hors des têtes de bobines, une formulation analytique peut être utilisée. Une méthode analytique utilisant le développemment en série de Fourier du courant est adoptée pour les industeurs cylindr...

High accuracy 3-D laser radar

DEFF Research Database (Denmark)

Busck, Jens; Heiselberg, Henning

2004-01-01

We have developed a mono-static staring 3-D laser radar based on gated viewing with range accuracy below 1 m at 10 m and 1 cm at 100. We use a high sensitivity, fast, intensified CCD camera, and a Nd:Yag passively Q-switched 32.4 kHz pulsed green laser at 532 nm. The CCD has 752x582 pixels. Camera...

A Note on R&D and Price Elasticity of Demand

DEFF Research Database (Denmark)

Schröder, Philipp J.H.; Schumacher, Dieter; Lucke, Dorothea

2005-01-01

This note explores the relationship between the price elasticity of demand and the R&D intensity of the product. We introduce the concept of R&D intensity into a standard Dixit-Stiglitz/Krugman-type setting. R&D activity is treated as a fixed cost of production. Within this framework, sectors...... with a higher R&D intensity show a lower price elasticity of demand. This proposition is confirmed by an empirical investigation of export demand for manufactured goods from major industrialised countries. Consequently, real exchange rate changes have an impact on the commodity structure of exports....

D and D projects trends

International Nuclear Information System (INIS)

Gay, Arnaud

2012-01-01

This series of slides presents: 1 - the Various types of needs and types of operations in any D and D project, 2 - the strong variety of nuclear units to dismantle, 3 - the D and D dependence on nuclear operators' strategy (Immediate/Deferred dismantling), 4 - the demand for D and D services with respect to the ageing of the nuclear fleet, 5 - the impacts to come on the D and D environment due to the Fukushima accident, 6 - the geographical dependence of D and D demands, 7 - the different D and D choices from nuclear operators in the supply chain management, 8 - the key levers in a D and D project performance, 9 - Some key competencies in D and D, 10 - Risk management for both clients and suppliers in a D and D project, 11 - AREVA involvement in Fukushima project as a key demonstration of a critical D and D project management

3-D Whole-Core Transport Calculation with 3D/2D Rotational Plane Slicing Method

Energy Technology Data Exchange (ETDEWEB)

Yoo, Han Jong; Cho, Nam Zin [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

2014-10-15

Use of the method of characteristics (MOC) is very popular due to its capability of heterogeneous geometry treatment and widely used for 2-D core calculation, but direct extension of MOC to 3-D core is not so attractive due to huge calculational cost. 2-D/1-D fusion method was very successful for 3-D calculation of current generation reactor types (highly heterogeneous in radial direction but piece-wise homogeneous in axial direction). In this paper, 2-D MOC concept is extended to 3-D core calculation with little modification of an existing 2-D MOC code. The key idea is to suppose 3-D geometry as a set of many 2-D planes like a phone-directory book. Dividing 3-D structure into a large number of 2-D planes and solving each plane with a simple 2-D SN transport method would give the solution of a 3-D structure. This method was developed independently at KAIST but it is found that this concept is similar with that of 'plane tracing' in the MCCG-3D code. The method developed was tested on the 3-D C5G7 OECD/NEA benchmark problem and compared with the 2-D/1-D fusion method. Results show that the proposed method is worth investigating further. A new approach to 3-D whole-core transport calculation is described and tested. By slicing 3-D structure along characteristic planes and solving each 2-D plane problem, we can get 3-D solution. The numerical test results indicate that the new method is comparable with the 2D/1D fusion method and outperforms other existing methods. But more fair comparison should be done in similar discretization level.

4D modeling in high-rise construction

Science.gov (United States)

Balakina, Anastasiya; Simankina, Tatyana; Lukinov, Vitaly

2018-03-01

High-rise construction is a complex construction process, requiring the use of more perfected and sophisticated tools for design, planning and construction management. The use of BIM-technologies allows minimizing the risks associated with design errors and errors that occur during construction. This article discusses a visual planning method using the 4D model, which allows the project team to create an accurate and complete construction plan, which is much more difficult to achieve with the help of traditional planning methods. The use of the 4D model in the construction of a 70-story building allowed to detect spatial and temporal errors before the start of construction work. In addition to identifying design errors, 4D modeling has allowed to optimize the construction, as follows: to optimize the operation of cranes, the placement of building structures and materials at various stages of construction, to optimize the organization of work performance, as well as to monitor the activities related to the preparation of the construction site for compliance with labor protection and safety requirements, which resulted in saving money and time.

D D Bansal

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. D D Bansal. Articles written in Resonance – Journal of Science Education. Volume 8 Issue 12 December 2003 pp 92-93 Research News. New Insights into Obesity · D D Bansal Ravneet Kaur Boparai · More Details Fulltext PDF ...

Clinical input of anti-D quantitation by continuous-flow analysis on autoanalyzer in the management of high-titer anti-D maternal alloimmunization.

Science.gov (United States)

Toly-Ndour, Cécile; Mourtada, Haifa; Huguet-Jacquot, Stéphanie; Maisonneuve, Emeline; Friszer, Stéphanie; Pernot, Françoise; Thomas, Pauline; Jouannic, Jean-Marie; Carbonne, Bruno; Cortey, Anne; Mailloux, Agnès

2018-02-01

In addition to titration by indirect antiglobulin test most widely used, anti-D quantitation by continuous-flow analysis (CFA) may be performed to assess severity of maternal immunization. Only five studies have reported its added value in the management of pregnancies complicated by anti-D immunization. A retrospective study of 74 severe anti-D-immunized pregnancies was conducted from January 1, 2013, to December 31, 2014, in the Trousseau Hospital in Paris (France). Concentration of maternal anti-D was measured by titration and by CFA two-stages method (2SM; total amount of anti-D) and one-stage method (1SM; high-affinity IgG1 anti-D). These biologic data were analyzed according to the severity of the hemolytic disease of the fetus and the newborn. The value of 5 IU anti-D/mL in maternal serum is validated as a threshold to trigger ultrasonographic and Doppler fetal close follow-up. A high 1SM/2SM ratio was associated with a higher risk of intrauterine transfusion (IUT). For pregnancies requiring IUT and without increasing titer, maternal 1SM anti-D concentration tends to correlate with the precocity of fetal anemia. In the "without-IUT" group 1SM and 2SM anti-D concentrations correlate significantly with cord bilirubin levels of the newborn at birth. Altogether our results underline the importance of anti-D quantitation by CFA to optimize the management of anti-D-alloimmunized pregnancies. © 2017 AABB.

Status of neutrino factory and muon collider R and D

International Nuclear Information System (INIS)

Zisman, M.S.

2001-01-01

A significant worldwide R and D effort is presently directed toward solving the technical challenges of producing, cooling, accelerating, storing, and eventually colliding beams of muons. Its primary thrust is toward issues critical to a Neutrino Factory, for which R and D efforts are under way in the U.S., via the Neutrino Factory and Muon Collider Collaboration (MC); in Europe, centered at CERN; and in Japan, at KEK. Under study and experimental development are production targets handling intense proton beams (1-4 MW), phase rotation systems to reduce beam energy spread, cooling channels to reduce transverse beam emittance for the acceleration system, and storage rings where muon decays in a long straight section provide a neutrino beam for a long-baseline (3000 km) experiment. Critical experimental activities include development of very high gradient normal conducting RF (NCRF) and superconducting RF (SCRF) cavities, high-power liquid-hydrogen absorbers, and high-field superconducting solenoids. Components and instrumentation that tolerate the intense decay products of the muon beam are being developed for testing. For a high-luminosity collider, muons must be cooled longitudinally as well as transversely, requiring an emittance exchange scheme. In addition to the experimental R and D effort, sophisticated theoretical and simulation tools are needed for the design. Here, the goals, present status, and future R and D plans in these areas will be described

Collapse and coalescence of spherical voids subject to intense shearing: studied in full 3D

DEFF Research Database (Denmark)

Nielsen, Kim Lau; Dahl, Jonas; Tvergaard, Viggo

2012-01-01

the numerical analysis, which is also reflected in published literature. Rather than moving towards very low triaxiality shearing, work has focused on extracting wide-ranging results for moderate stress triaxiality (T ~ 1), in order to achieve sufficient understanding of the influence of initial porosity, void...... significant straining of the matrix material located on the axis of rotation. In particular, the void surface material is severely deformed during shearing and void surface contact is established early in the deformation process. This 3D effect intensifies with decreasing stress triaxiality and complicates...... shape, void orientation etc. The objective of this work is to expand the range of stress triaxiality usually faced in 3D cell model studies, such that intense shearing is covered, and to bring forward details on the porosity and void shape evolution. The overall material response is presented...

Joint sparse learning for 3-D facial expression generation.

Science.gov (United States)

Song, Mingli; Tao, Dacheng; Sun, Shengpeng; Chen, Chun; Bu, Jiajun

2013-08-01

3-D facial expression generation, including synthesis and retargeting, has received intensive attentions in recent years, because it is important to produce realistic 3-D faces with specific expressions in modern film production and computer games. In this paper, we present joint sparse learning (JSL) to learn mapping functions and their respective inverses to model the relationship between the high-dimensional 3-D faces (of different expressions and identities) and their corresponding low-dimensional representations. Based on JSL, we can effectively and efficiently generate various expressions of a 3-D face by either synthesizing or retargeting. Furthermore, JSL is able to restore 3-D faces with holes by learning a mapping function between incomplete and intact data. Experimental results on a wide range of 3-D faces demonstrate the effectiveness of the proposed approach by comparing with representative ones in terms of quality, time cost, and robustness.

2D:4D digit ratio predicts delay of gratification in preschoolers.

Directory of Open Access Journals (Sweden)

Sergio Da Silva

Full Text Available We replicate the Stanford marshmallow experiment with a sample of 141 preschoolers and find a correlation between lack of self-control and 2D:4D digit ratio. Children with low 2D:4D digit ratio are less likely to delay gratification. Low 2D:4D digit ratio may indicate high fetal testosterone. If this hypothesis is true, our finding means high fetal testosterone children are less likely to delay gratification.

D and D knowledge management information tool - a web based system developed to share D and D knowledge worldwide

International Nuclear Information System (INIS)

Lagos, L.; Upadhyay, H.; Shoffner, P.

2013-01-01

Deactivation and decommissioning (D and D) work is a high risk and technically challenging enterprise within the U.S. Department of Energy complex. During the past three decades, the DOE's Office of Environmental Management has been in charge of carrying out one of the largest environmental restoration efforts in the world: the cleanup of the Manhattan Project legacy. In today's corporate world, worker experiences and knowledge that have developed over time represent a valuable corporate asset. The ever-dynamic workplace, coupled with an aging workforce, presents corporations with the ongoing challenge of preserving work-related experiences and knowledge for cross-generational knowledge transfer to the future workforce [5]. To prevent the D and D knowledge base and expertise from being lost over time, the DOE and the Applied Research Center at Florida International University (FIU) have developed the web-based Knowledge Management Information Tool (KM-IT) to capture and maintain this valuable information in a universally available and easily accessible and usable system. The D and D KM-IT was developed in collaboration with DOE Headquarters (HQ), the Energy Facility Contractors Group (EFCOG), and the ALARA [as low as reasonably achievable] Centers at Savannah River Sites to preserve the D and D information generated and collected by the D and D community. This is an open secured system that can be accessed from https://www.dndkm.org over the web and through mobile devices at https://m.dndkm.org. This knowledge system serves as a centralized repository and provides a common interface for D and D-related activities. It also improves efficiency by reducing the need to rediscover knowledge and promotes the reuse of existing knowledge. It is a community-driven system that facilitates the gathering, analyzing, storing, and sharing of knowledge and information within the D and D community. It assists the DOE D and D community in identifying potential solutions

D and D knowledge management information tool - a web based system developed to share D and D knowledge worldwide

Energy Technology Data Exchange (ETDEWEB)

Lagos, L.; Upadhyay, H.; Shoffner, P. [Applied Research Center, Florida International University, 10555 W. Flagler Street,EC2100, Miami, FL (United States)

2013-07-01

Deactivation and decommissioning (D and D) work is a high risk and technically challenging enterprise within the U.S. Department of Energy complex. During the past three decades, the DOE's Office of Environmental Management has been in charge of carrying out one of the largest environmental restoration efforts in the world: the cleanup of the Manhattan Project legacy. In today's corporate world, worker experiences and knowledge that have developed over time represent a valuable corporate asset. The ever-dynamic workplace, coupled with an aging workforce, presents corporations with the ongoing challenge of preserving work-related experiences and knowledge for cross-generational knowledge transfer to the future workforce [5]. To prevent the D and D knowledge base and expertise from being lost over time, the DOE and the Applied Research Center at Florida International University (FIU) have developed the web-based Knowledge Management Information Tool (KM-IT) to capture and maintain this valuable information in a universally available and easily accessible and usable system. The D and D KM-IT was developed in collaboration with DOE Headquarters (HQ), the Energy Facility Contractors Group (EFCOG), and the ALARA [as low as reasonably achievable] Centers at Savannah River Sites to preserve the D and D information generated and collected by the D and D community. This is an open secured system that can be accessed from https://www.dndkm.org over the web and through mobile devices at https://m.dndkm.org. This knowledge system serves as a centralized repository and provides a common interface for D and D-related activities. It also improves efficiency by reducing the need to rediscover knowledge and promotes the reuse of existing knowledge. It is a community-driven system that facilitates the gathering, analyzing, storing, and sharing of knowledge and information within the D and D community. It assists the DOE D and D community in identifying potential solutions

3D Terahertz Beam Profiling

DEFF Research Database (Denmark)

Pedersen, Pernille Klarskov; Strikwerda, Andrew; Jepsen, Peter Uhd

2013-01-01

We present a characterization of THz beams generated in both a two-color air plasma and in a LiNbO3 crystal. Using a commercial THz camera, we record intensity images as a function of distance through the beam waist, from which we extract 2D beam profiles and visualize our measurements into 3D beam...

Physics study of D-D/D-T neutron driven experimental subcritical assembly

International Nuclear Information System (INIS)

Sinha, Amar

2015-01-01

An experimental program to design and study external source driven subcritical assembly has been initiated at BARC. This program is aimed at understanding neutronic characteristics of accelerator driven system at low power level. In this series, a zero-power, sub-critical assembly driven by a D-D/D-T neutron generator has been developed. This system is modular in design and it is first in the series of subcritical assemblies being designed. The subcritical core consists of natural uranium fuel with high density polyethylene as moderator and beryllium oxide as reflector. The subcritical core is coupled to Purnima Neutron Generator. Preliminary experiments have been carried out for spatial flux measurement and reactivity estimation using pulsed neutron source (PNS) techniques. Further experiments are being planned to measure the reactivity and other kinetic parameters using noise methods. This facility would also be used for carrying out studies on effect of source importance and measurement of source multiplication factor k s and external neutron source efficiency φ* in great details. Some experiments with D-D and D-T neutrons have been presented. (author)

Foreign acquisitions, domestic multinationals, and R&D

DEFF Research Database (Denmark)

Bandick, Roger; Görg, Holger; Karpaty, Patrik

endogeneity of the acquisition dummy.  Overall, our results give no support to the fears that foreign acquisition of domestic firms lead to a brain drain of R&D activity in Swedish MNEs. Rather, this paper finds robust evidence that foreign acquisitions lead to increasing R&D intensity in acquired domestic......The aim of this paper is to evaluate the causal effect of foreign acquisition on R&D intensity in targeted domestic firms. We are able to distinguish domestic multinationals and non-multinationals, which allows us to investigate the fear that the change in ownership of domestic to foreign...

Multiview 3D sensing and analysis for high quality point cloud reconstruction

Science.gov (United States)

Satnik, Andrej; Izquierdo, Ebroul; Orjesek, Richard

2018-04-01

Multiview 3D reconstruction techniques enable digital reconstruction of 3D objects from the real world by fusing different viewpoints of the same object into a single 3D representation. This process is by no means trivial and the acquisition of high quality point cloud representations of dynamic 3D objects is still an open problem. In this paper, an approach for high fidelity 3D point cloud generation using low cost 3D sensing hardware is presented. The proposed approach runs in an efficient low-cost hardware setting based on several Kinect v2 scanners connected to a single PC. It performs autocalibration and runs in real-time exploiting an efficient composition of several filtering methods including Radius Outlier Removal (ROR), Weighted Median filter (WM) and Weighted Inter-Frame Average filtering (WIFA). The performance of the proposed method has been demonstrated through efficient acquisition of dense 3D point clouds of moving objects.

Styrylpyrylium Salts: 1H and 13C NMR High-Resolution Spectroscopy (1D and 2D

Directory of Open Access Journals (Sweden)

Jean Claude W. Ouédraogo

2010-01-01

Full Text Available 1H and 13C NMR high-resolution spectroscopy (1D and 2D (1H, 1H-COSY, HSQC, HMBC for four styrylpyrylium perchlorates were carried out and signal attributions are reported. Chemical shifts observed on 13C NMR spectra for the styrylpyrylium salts were compared with net atomic charge for carbon obtained by AM1 semiempirical calculations. The position of the styryl group present low effect on chemical shifts for carbon atoms, while the presence of methyl group led to the unshielding of the substituted carbon.

Beam halo in high-intensity beams

International Nuclear Information System (INIS)

Wangler, T.P.

1993-01-01

In space-charge dominated beams the nonlinear space-charge forces produce a filamentation pattern, which in projection to the 2-D phase spaces results in a 2-component beam consisting of an inner core and a diffuse outer halo. The beam-halo is of concern for a next generation of cw, high-power proton linacs that could be applied to intense neutron generators for nuclear materials processing. The author describes what has been learned about beam halo and the evolution of space-charge dominated beams using numerical simulations of initial laminar beams in uniform linear focusing channels. Initial results are presented from a study of beam entropy for an intense space-charge dominated beam

Dry-boxes for manipulation of high-energy {beta} emitters; Bottes pour manipulation d'emetteurs {beta} energiques

Energy Technology Data Exchange (ETDEWEB)

Boclet, K; Laurent, H [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

Because of the thinners of latex or neoprene gloves and the high intensity of Bremsstrahlung radiation, manipulation of pure high-energy {beta}{sup -} emitters is impossible in ordinary dry-boxes. There are many types of box equipped with heavy lead or steel protection, but their use for radioelements such as {sup 32}P, {sup 90}Sr, {sup 90}Y is not justified. We have devised units known as 'tong boxes' which, while retaining much of the flexibility of operation found in dry-boxes, provide adequate protection. 1 curie of {sup 32}P placed in the centre of the enclosure gives about 15 mR/ 8 h. at the part of the wall closest to the source. (author) [French] La faible epaisseur des gants de latex ou de neoprene et l'importance du rayonnement de freinage rendent impossible la manipulation des emetteurs {beta}{sup -} purs energiques dans des boites a gants normales. Il existe de nombreux types d'enceintes dotees d'une forte protection de plomb ou d'acier dont l'emploi n'est pas justifie pour des radioelements tels que {sup 32}P, {sup 90}Sr, {sup 90}Y. Nous avons realise des ensembles appeles 'Boites a Pinces', qui tout en conservant une grande partie de la souplesse d'utilisation des boites a gants sont dotees d'une protection suffisante. 1 curie de {sup 32}P place au centre de l'enceinte donne environ 15 mR/ 8 h au contact de la paroi la plus rapprochee de la source. (auteur)

Physics of high performance JET plasmas in D-T

International Nuclear Information System (INIS)

2001-01-01

JET has recently operated with deuterium-tritium (D-T) mixtures, carried out an ITER physics campaign in hydrogen, deuterium, D-T and tritium, installed the Mark IIGB ''Gas Box'' divertor fully by remote handling and started physics experiments with this more closed divertor. The D-T experiments set records for fusion power (16.1 MW), ratio of fusion power to plasma input power (0.62, and 0.95±0.17 if a similar plasma could be obtained in steady-state) and fusion duration (4 MW for 4 s). A large scale tritium supply and processing plant, the first of its kind, allowed the repeated use of the 20 g tritium on site to supply 99.3 g of tritium to the machine. The H-mode threshold power is significantly lower in D-T, but the global energy confinement time is practically unchanged (no isotope effect). Dimensionless scaling ''Wind Tunnel'' experiments in D-T extrapolate to ignition with ITER parameters. The scaling is close to gyroBohm, but the mass dependence is not correct. Separating the thermal plasma energy into core and pedestal contributions could resolve this discrepancy (leading to proper gyroBohm scaling for the core) and also account for confinement degradation at high density and at high radiated power. Four radio frequency heating schemes have been tested successfully in D-T, showing good agreement with calculations. Alpha particle heating has been clearly observed and is consistent with classical expectations. Internal transport barriers have been established in optimised magnetic shear discharges for the first time in D-T and steady-state conditions have been approached with simultaneous internal and edge transport barriers. First results with the newly installed Mark IIGB divertor show that the in/out symmetry of the divertor plasma can be modified using differential gas fuelling, that optimised shear discharges can be produced, and that krypton gas puffing is effective in restoring L-mode edge conditions and establishing an internal transport barrier in

Physics of high performance jet plasmas in D-T

International Nuclear Information System (INIS)

1999-01-01

JET has recently operated with deuterium-tritium (D-T) mixtures, carried out an ITER physics campaign in hydrogen, deuterium, D-T and tritium, installed the Mark IIGB 'Gas Box' divertor fully by remote handling and started physics experiments with this more closed divertor. The D-T experiments set records for fusion power (16.1 MW), ratio of fusion power to plasma input power (0.62, and 0.95±0.17 if a similar plasma could be obtained in steady-state) and fusion duration (4 MW for 4 s). A large scale tritium supply and processing plant, the first of its kind, allowed the repeated use of the 20 g tritium on site to supply 99.3 g of tritium to the machine. The H-mode threshold power is significantly lower in D-T, but the global energy confinement time is practically unchanged (no isotope effect). Dimensionless scaling 'Wind Tunnel' experiments in D-T extrapolate to ignition with ITER parameters. The scaling is close to gyroBohm, but the mass dependence is not correct. Separating the thermal plasma energy into core and pedestal contributions could resolve this discrepancy (leading to proper gyroBohm scaling for the core) and also account for confinement degradation at high density and at high radiated power. Four radio frequency heating schemes have been tested successfully in D-T, showing good agreement with calculations. Alpha particle heating has been clearly observed and is consistent with classical expectations. Internal transport barriers have been established in optimised magnetic shear discharges for the first time in D-T and steady-state conditions have been approached with simultaneous internal and edge transport barriers. First results with the newly installed Mark IIGB divertor show that the in/out symmetry of the divertor plasma can be modified using differential gas fuelling, that optimised shear discharges can be produced, and that krypton gas puffing is effective in restoring L-mode edge conditions and establishing an internal transport barrier in such

SiGe HBT linear-in-dB high dynamic range RF envelope detectors and wideband high linearity amplifiers

OpenAIRE

Pan, Hsuan-yu

2010-01-01

This research work aims on exploiting SiGe HBT technologies in high dynamic range wideband RF linear-in- dB envelope detectors and linear amplifiers. First, an improved all-npn broadband highly linear SiGe HBT differential amplifier is presented based on a variation of Caprio's Quad. A broadband linear amplifier with 46dBm OIP₃ at 20MHz, 34dBm OIP₃ at 1GHz, 6dB noise figure and 10.3dBm P₁dB is demonstrated. Second, an improved exact dynamic model of a fast-settling linear-in-dB Automatic Gain...

Genotoxic Effects of Low- and High-LET Radiation on Human Epithelial Cells Grown in 2-D Versus 3-D Culture

Science.gov (United States)

Patel, Z. S.; Cucinotta, F. A.; Huff, J. L.

2011-01-01

Risk estimation for radiation-induced cancer relies heavily on human epidemiology data obtained from terrestrial irradiation incidents from sources such as medical and occupational exposures as well as from the atomic bomb survivors. No such data exists for exposures to the types and doses of high-LET radiation that will be encountered during space travel; therefore, risk assessment for space radiation requires the use of data derived from cell culture and animal models. The use of experimental models that most accurately replicate the response of human tissues is critical for precision in risk projections. This work compares the genotoxic effects of radiation on normal human epithelial cells grown in standard 2-D monolayer culture compared to 3-D organotypic co-culture conditions. These 3-D organotypic models mimic the morphological features, differentiation markers, and growth characteristics of fully-differentiated normal human tissue and are reproducible using defined components. Cultures were irradiated with 2 Gy low-LET gamma rays or varying doses of high-LET particle radiation and genotoxic damage was measured using a modified cytokinesis block micronucleus assay. Our results revealed a 2-fold increase in residual damage in 2 Gy gamma irradiated cells grown under organotypic culture conditions compared to monolayer culture. Irradiation with high-LET particle radiation gave similar results, while background levels of damage were comparable under both scenarios. These observations may be related to the phenomenon of "multicellular resistance" where cancer cells grown as 3-D spheroids or in vivo exhibit an increased resistance to killing by chemotherapeutic agents compared to the same cells grown in 2-D culture. A variety of factors are likely involved in mediating this process, including increased cell-cell communication, microenvironment influences, and changes in cell cycle kinetics that may promote survival of damaged cells in 3-D culture that would

Anti-N-Methyl-d-Aspartate Receptor Encephalitis in Adult Patients Requiring Intensive Care.

Science.gov (United States)

de Montmollin, Etienne; Demeret, Sophie; Brulé, Noëlle; Conrad, Marie; Dailler, Frédéric; Lerolle, Nicolas; Navellou, Jean-Christophe; Schwebel, Carole; Alves, Mikaël; Cour, Martin; Engrand, Nicolas; Tonnelier, Jean-Marie; Maury, Eric; Ruckly, Stéphane; Picard, Géraldine; Rogemond, Véronique; Magalhaes, Éric; Sharshar, Tarek; Timsit, Jean-François; Honnorat, Jérôme; Sonneville, Romain

2017-02-15

Encephalitis caused by anti-N-methyl-d-aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis. There are limited data on intensive care unit (ICU) management of these patients. To identify prognostic factors of good neurologic outcome in patients admitted to an ICU with anti-NMDAR encephalitis. This was an observational multicenter study of all consecutive adult patients diagnosed with anti-NMDAR encephalitis at the French National Reference Centre, admitted to an ICU between 2008 and 2014. The primary outcome was a good neurologic outcome at 6 months after ICU admission, defined by a modified Rankin Scale score of 0-2. Seventy-seven patients were included from 52 ICUs. First-line immunotherapy consisted of steroids (n = 61/74; 82%), intravenous immunoglobulins (n = 71/74; 96%), and plasmapheresis (n = 17/74; 23%). Forty-five (61%) patients received second-line immunotherapy (cyclophosphamide, rituximab, or both). At 6 months, 57% of patients had a good neurologic outcome. Independent factors of good neurologic outcome were early (≤8 d after ICU admission) immunotherapy (odds ratio, 16.16; 95% confidence interval, 3.32-78.64; for combined first-line immunotherapy with steroids and intravenous immunoglobulins vs. late immunotherapy), and a low white blood cell count on the first cerebrospinal examination (odds ratio, 9.83 for 50 cells/mm 3 ; 95% confidence interval, 1.07-90.65). Presence of nonneurologic organ failures at ICU admission and occurrence of status epilepticus during ICU stay were not associated with neurologic outcome. The prognosis of adult patients with anti-NMDAR encephalitis requiring intensive care is good, especially when immunotherapy is initiated early, advocating for prompt diagnosis and early aggressive treatment.

Spatial and spectral coherence in propagating high-intensity twin beams

Czech Academy of Sciences Publication Activity Database

Haderka, O.; Machulka, R.; Peřina ml., Jan; Allevi, A.; Bondani, M.

2015-01-01

Roč. 5, Sep (2015), s. 14365 ISSN 2045-2322 R&D Projects: GA ČR GAP205/12/0382 Institutional support: RVO:68378271 Keywords : spatial and spectral coherence * high-intensity twin beams Subject RIV: BH - Optics, Masers, Lasers Impact factor: 5.228, year: 2015

4D modeling in high-rise construction

Directory of Open Access Journals (Sweden)

Balakina Anastasiya

2018-01-01

Full Text Available High-rise construction is a complex construction process, requiring the use of more perfected and sophisticated tools for design, planning and construction management. The use of BIM-technologies allows minimizing the risks associated with design errors and errors that occur during construction. This article discusses a visual planning method using the 4D model, which allows the project team to create an accurate and complete construction plan, which is much more difficult to achieve with the help of traditional planning methods. The use of the 4D model in the construction of a 70-story building allowed to detect spatial and temporal errors before the start of construction work. In addition to identifying design errors, 4D modeling has allowed to optimize the construction, as follows: to optimize the operation of cranes, the placement of building structures and materials at various stages of construction, to optimize the organization of work performance, as well as to monitor the activities related to the preparation of the construction site for compliance with labor protection and safety requirements, which resulted in saving money and time.

A high efficiency PWM CMOS class-D audio power amplifier

Energy Technology Data Exchange (ETDEWEB)

Zhu Zhangming; Liu Lianxi; Yang Yintang [Institute of Microelectronics, Xidian University, Xi' an 710071 (China); Lei Han, E-mail: zmyh@263.ne [Xi' an Power-Rail Micro Co., Ltd, Xi' an 710075 (China)

2009-02-15

Based on the difference close-loop feedback technique and the difference pre-amp, a high efficiency PWM CMOS class-D audio power amplifier is proposed. A rail-to-rail PWM comparator with window function has been embedded in the class-D audio power amplifier. Design results based on the CSMC 0.5 mum CMOS process show that the max efficiency is 90%, the PSRR is -75 dB, the power supply voltage range is 2.5-5.5 V, the THD+N in 1 kHz input frequency is less than 0.20%, the quiescent current in no load is 2.8 mA, and the shutdown current is 0.5 muA. The active area of the class-D audio power amplifier is about 1.47 x 1.52 mm{sup 2}. With the good performance, the class-D audio power amplifier can be applied to several audio power systems.

A high efficiency PWM CMOS class-D audio power amplifier

International Nuclear Information System (INIS)

Zhu Zhangming; Liu Lianxi; Yang Yintang; Lei Han

2009-01-01

Based on the difference close-loop feedback technique and the difference pre-amp, a high efficiency PWM CMOS class-D audio power amplifier is proposed. A rail-to-rail PWM comparator with window function has been embedded in the class-D audio power amplifier. Design results based on the CSMC 0.5 μm CMOS process show that the max efficiency is 90%, the PSRR is -75 dB, the power supply voltage range is 2.5-5.5 V, the THD+N in 1 kHz input frequency is less than 0.20%, the quiescent current in no load is 2.8 mA, and the shutdown current is 0.5 μA. The active area of the class-D audio power amplifier is about 1.47 x 1.52 mm 2 . With the good performance, the class-D audio power amplifier can be applied to several audio power systems.

A high efficiency PWM CMOS class-D audio power amplifier

Science.gov (United States)

Zhangming, Zhu; Lianxi, Liu; Yintang, Yang; Han, Lei

2009-02-01

Based on the difference close-loop feedback technique and the difference pre-amp, a high efficiency PWM CMOS class-D audio power amplifier is proposed. A rail-to-rail PWM comparator with window function has been embedded in the class-D audio power amplifier. Design results based on the CSMC 0.5 μm CMOS process show that the max efficiency is 90%, the PSRR is -75 dB, the power supply voltage range is 2.5-5.5 V, the THD+N in 1 kHz input frequency is less than 0.20%, the quiescent current in no load is 2.8 mA, and the shutdown current is 0.5 μA. The active area of the class-D audio power amplifier is about 1.47 × 1.52 mm2. With the good performance, the class-D audio power amplifier can be applied to several audio power systems.

Report on Workshop on Future Directions for Accelerator R&D at Fermilab

Energy Technology Data Exchange (ETDEWEB)

Shiltsev, V.; Church, M.; Spentzouris, P.; Chou, W.; /Fermilab

2009-09-01

Accelerator R&D has played a crucial role in enabling scientific discovery in the past century and will continue to play this role in the years to come. In the U.S., the Office of High Energy Physics of DOE's Office of Science is developing a plan for national accelerator R&D stewardship. Fermilab undertakes accelerator research, design, and development focused on superconducting radio-frequency (RF), superconducting magnet, beam cooling, and high intensity proton technologies. In addition, the Lab pursues comprehensive integrated theoretical concepts and simulations of complete future facilities on both the energy and intensity frontiers. At present, Fermilab (1) supplies integrated design concept and technology development for a multi-MW proton source (Project X) to support world-leading programs in long baseline neutrino and rare processes experiments; (2) plays a leading role in the development of ionization cooling technologies required for muon storage ring facilities at the energy (multi-TeV Muon Collider) and intensity (Neutrino Factory) frontiers, and supplies integrated design concepts for these facilities; and (3) carries out a program of advanced accelerator R&D (AARD) in the field of high quality beam sources, and novel beam manipulation techniques.

Nature-Inspired 2D-Mosaic 3D-Gradient Mesoporous Framework: Bimetal Oxide Dual-Composite Strategy toward Ultrastable and High-Capacity Lithium Storage.

Science.gov (United States)

Yu, Jia; Wang, Yanlei; Mou, Lihui; Fang, Daliang; Chen, Shimou; Zhang, Suojiang

2018-02-27

In allusion to traditional transition-metal oxide (TMO) anodes for lithium-ion batteries, which face severe volume variation and poor conductivity, herein a bimetal oxide dual-composite strategy based on two-dimensional (2D)-mosaic three-dimensional (3D)-gradient design is proposed. Inspired by natural mosaic dominance phenomena, Zn 1-x Co x O/ZnCo 2 O 4 2D-mosaic-hybrid mesoporous ultrathin nanosheets serve as building blocks to assemble into a 3D Zn-Co hierarchical framework. Moreover, a series of derivative frameworks with high evolution are controllably synthesized, based on which a facile one-pot synthesis process can be developed. From a component-composite perspective, both Zn 1-x Co x O and ZnCo 2 O 4 provide superior conductivity due to bimetal doping effect, which is verified by density functional theory calculations. From a structure-composite perspective, 2D-mosaic-hybrid mode gives rise to ladder-type buffering and electrochemical synergistic effect, thus realizing mutual stabilization and activation between the mosaic pair, especially for Zn 1-x Co x O with higher capacity yet higher expansion. Moreover, the inside-out Zn-Co concentration gradient in 3D framework and rich oxygen vacancies further greatly enhance Li storage capability and stability. As a result, a high reversible capacity (1010 mA h g -1 ) and areal capacity (1.48 mA h cm -2 ) are attained, while ultrastable cyclability is obtained during high-rate and long-term cycles, rending great potential of our 2D-mosaic 3D-gradient design together with facile synthesis.

4D RECONSTRUCTIONS FROM LOW-COUNT SPECT DATA USING DEFORMABLE MODELS WITH SMOOTH INTERIOR INTENSITY VARIATIONS

International Nuclear Information System (INIS)

Cunningham, G. S.; Lehovich, A.

2000-01-01

The Bayes Inference Engine (BIE) has been used to perform a 4D reconstruction of a first-pass radiotracer bolus distribution inside a CardioWest Total Artificial Heart, imaged with the University of Arizona's FastSPECT system. The BIE estimates parameter values that define the 3D model of the radiotracer distribution at each of 41 times spanning about two seconds. The 3D models have two components: a closed surface, composed of hi-quadratic Bezier triangular surface patches, that defines the interface between the part of the blood pool that contains radiotracer and the part that contains no radiotracer, and smooth voxel-to-voxel variations in intensity within the closed surface. Ideally, the surface estimates the ventricular wall location where the bolus is infused throughout the part of the blood pool contained by the right ventricle. The voxel-to-voxel variations are needed to model an inhomogeneously-mixed bolus. Maximum a posterior (MAP) estimates of the Bezier control points and voxel values are obtained for each time frame. We show new reconstructions using the Bezier surface models, and discuss estimates of ventricular volume as a function of time, ejection fraction, and wall motion. The computation time for our reconstruction process, which directly estimates complex 3D model parameters from the raw data, is performed in a time that is competitive with more traditional voxel-based methods (ML-EM, e.g.)

Experimental investigations on the fluid flow through a wall subchannel of a rod bundle (P/D = 1.036, W/D = 1.072)

International Nuclear Information System (INIS)

Rehme, K.

1982-07-01

Measurements of the distributions of the mean velocity, the wall shear stresses and the turbulence were performed in a wall subchannel of a rod bundle of four parallel rods arranged symmetrically in a rectangular channel (P/D = 1.036, W/D = 1.072). The Reynolds number of this investigation was Re = 7.60 x 10 4 . The experimental results show that the momentum transport is highly anisotropic especially in the gaps of the rod bundle. Influences of secondary flow cannot be detected in the distribution of the time-mean velocity, however, such influences are found in the distributions of the turbulence intensities and the kinetic energy of turbulence. Very high turbulence intensities were observed in the gap between the rods. The comparison between experimental wall shear stress distributions and those calculated with the VELASCO-code shows discrepancies especially in the gap between the rods. (orig.) [de

The effect of a single early high-dose vitamin D supplement on fracture union in patients with hypovitaminosis D: a prospective randomised trial.

Science.gov (United States)

Haines, N; Kempton, L B; Seymour, R B; Bosse, M J; Churchill, C; Hand, K; Hsu, J R; Keil, D; Kellam, J; Rozario, N; Sims, S; Karunakar, M A

2017-11-01

To evaluate the effect of a single early high-dose vitamin D supplement on fracture union in patients with hypovitaminosis D and a long bone fracture. Between July 2011 and August 2013, 113 adults with a long bone fracture were enrolled in a prospective randomised double-blind placebo-controlled trial. Their serum vitamin D levels were measured and a total of 100 patients were found to be vitamin D deficient (vitamin D 3 orally (100 000 IU) within two weeks of injury (treatment group, n = 50) or a placebo (control group, n = 50). We recorded patient demographics, fracture location and treatment, vitamin D level, time to fracture union and complications, including vitamin D toxicity. Outcomes included union, nonunion or complication requiring an early, unplanned secondary procedure. Patients without an outcome at 15 months and no scheduled follow-up were considered lost to follow-up. The t -test and cross tabulations verified the adequacy of randomisation. An intention-to-treat analysis was carried out. In all, 100 (89%) patients had hypovitaminosis D. Both treatment and control groups had similar demographics and injury characteristics. The initial median vitamin D levels were 16 ng/mL (interquartile range 5 to 28) in both groups (p = 0.885). A total of 14 patients were lost to follow-up (seven from each group), two had fixation failure (one in each group) and one control group patient developed an infection. Overall, the nonunion rate was 4% (two per group). No patient showed signs of clinical toxicity from their supplement. Despite finding a high level of hypovitaminosis D, the rate of union was high and independent of supplementation with vitamin D 3 . Cite this article: Bone Joint J 2017;99-B:1520-5. ©2017 The British Editorial Society of Bone & Joint Surgery.

A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT

International Nuclear Information System (INIS)

Koivunoro, H.; Lou, T.P.; Leung, K. N.; Reijonen, J.

2003-01-01

Boron-neutron capture therapy (BNCT) is an experimental radiation treatment modality used for highly malignant tumor treatments. Prior to irradiation with low energetic neutrons, a 10B compound is located selectively in the tumor cells. The effect of the treatment is based on the high LET radiation released in the 10 B(n,α) 7 Li reaction with thermal neutrons. BNCT has been used experimentally for brain tumor and melanoma treatments. Lately applications of other severe tumor type treatments have been introduced. Results have shown that liver tumors can also be treated by BNCT. At Lawrence Berkeley National Laboratory, various compact neutron generators based on D-D or D-T fusion reactions are being developed. The earlier theoretical studies of the D-D or D-T fusion reaction based neutron generators have shown that the optimal moderator and reflector configuration for brain tumor BNCT can be created. In this work, the applicability of 2.5 MeV neutrons for liver tumor BNCT application was studied. The optimal neutron energy for external liver treatments is not known. Neutron beams of different energies (1eV < E < 100 keV) were simulated and the dose distribution in the liver was calculated with the MCNP simulation code. In order to obtain the optimal neutron energy spectrum with the D-D neutrons, various moderator designs were performed using MCNP simulations. In this article the neutron spectrum and the optimized beam shaping assembly for liver tumor treatments is presented

Growth of porous anodized alumina on the sputtered aluminum films with 2D-3D morphology for high specific surface area

Science.gov (United States)

Liao, M. W.; Chung, C. K.

2014-08-01

The porous anodic aluminum oxide (AAO) with high-aspect-ratio pore channels is widely used as a template for fabricating nanowires or other one-dimensional (1D) nanostructures. The high specific surface area of AAO can also be applied to the super capacitor and the supporting substrate for catalysis. The rough surface could be helpful to enhance specific surface area but it generally results in electrical field concentration even to ruin AAO. In this article, the aluminum (Al) films with the varied 2D-3D morphology on Si substrates were prepared using magnetron sputtering at a power of 50 W-185 W for 1 h at a working pressure of 2.5 × 10-1 Pa. Then, AAO was fabricated from the different Al films by means of one-step hybrid pulse anodizing (HPA) between the positive 40 V and the negative -2 V (1 s:1 s) for 3 min in 0.3 M oxalic acid at a room temperature. The microstructure and morphology of Al films were characterized by X-ray diffraction, scanning electron microscope and atomic force microscope, respectively. Some hillocks formed at the high target power could be attributed to the grain texture growth in the normal orientation of Al(1 1 1). The 3D porous AAO structure which is different from the conventional 2D planar one has been successfully demonstrated using HPA on the film with greatly rough hillock-surface formed at the highest power of 185 W. It offers a potential application of the new 3D AAO to high specific surface area devices.

3-D printing of liquid metals for stretchable and flexible conductors

Science.gov (United States)

Trlica, Chris; Parekh, Dishit Paresh; Panich, Lazar; Ladd, Collin; Dickey, Michael D.

2014-06-01

3-D printing is an emerging technology that has been used primarily on small scales for rapid prototyping, but which could also herald a wider movement towards decentralized, highly customizable manufacturing. Polymers are the most common materials to be 3-D printed today, but there is great demand for a way to easily print metals. Existing techniques for 3-D printing metals tend to be expensive and energy-intensive, and usually require high temperatures or pressures, making them incompatible with polymers, organics, soft materials, and biological materials. Here, we describe room temperature liquid metals as complements to polymers for 3-D printing applications. These metals enable the fabrication of soft, flexible, and stretchable devices. We survey potential room temperature liquid metal candidates and describe the benefits of gallium and its alloys for these purposes. We demonstrate the direct printing of a liquid gallium alloy in both 2-D and 3-D and highlight the structures and shapes that can be fabricated using these processes.

Design of a high-temperature first wall/blanket for a d-d compact Reversed-Field-Pinch reactor (CRFPR)

International Nuclear Information System (INIS)

Dabiri, A.E.; Glancy, J.E.

1983-05-01

A high-temperature first wall/blanket which would take full advantage of the absence of tritium breeding in a d-d reactor was designed. This design which produces steam at p = 7 MPa and T = 538 0 C at the blanket exit eliminates the requirement for a separate steam generator. A steam cycle with steam-to-steam reheat yielding about 37.5 percent efficiency is compatible with this design

Poster - Thurs Eve-09: Evaluation of a commercial 2D ion-chamber array for intensity modulated radiation therapy dose measurements.

Science.gov (United States)

Mei, X; Bracken, G; Kerr, A

2008-07-01

Experimental verification of calculated dose from a treatment planning system is often essential for quality assurance (QA) of intensity modulated radiation therapy (IMRT). Film dosimetry and single ion chamber measurements are commonly used for IMRT QA. Film dosimetry has very good spatial resolution, but is labor intensive and absolute dose is not reliable. Ion chamber measurements are still required for absolute dose after measurements using films. Dosimeters based on 2D detector arrays that can measure 2D dose in real-time are gaining wider use. These devices provide a much easier and reliable tool for IMRT QA. We report the evaluation of a commercial 2D ion chamber array, including its basic performance characteristics, such as linearity, reproducibility and uniformity of relative ion chamber sensitivities, and comparisons between measured 2D dose and calculated dose with a commercial treatment planning system. Our analysis shows this matrix has excellent linearity and reproducibility, but relative sensitivities are tilted such that the +Y region is over sensitive, while the -Y region is under sensitive. Despite this behavior, our results show good agreement between measured 2D dose profiles and Eclipse planned data for IMRT test plans and a few verification plans for clinical breast field-in-field plans. The gamma values (3% or 3 mm distance-to-agreement) are all less than 1 except for one or two pixels at the field edge This device provides a fast and reliable stand-alone dosimeter for IMRT QA. © 2008 American Association of Physicists in Medicine.

Thermoelastic expansion vs. piezoelectricity for high-frequency, 2-D arrays.

Science.gov (United States)

Buma, Takashi; Spisar, Monica; O'Donnell, Matthew

2003-08-01

Optical generation using the thermoelastic effect has traditionally suffered from low conversion efficiency. We previously demonstrated increased efficiency of nearly 20 dB with an optical absorbing layer consisting of a mixture of polydimethylsiloxane (PDMS) and carbon black spin coated onto a glass microscope slide. In this paper we show that the radiated power from a black PDMS film is comparable to a 20 MHz piezoelectric two-dimensional (2-D) array element. Furthermore, we predict that a thermoelastic array element can produce similar acoustic power levels compared to ideal piezoelectric 2-D array elements at frequencies in the 100 MHz regime. We believe these results show that thermoelastic generation of ultrasound is a promising alternative to piezoelectricity for high-frequency, 2-D arrays.

Contributions in compression of 3D medical images and 2D images; Contributions en compression d'images medicales 3D et d'images naturelles 2D

Energy Technology Data Exchange (ETDEWEB)

Gaudeau, Y

2006-12-15

The huge amounts of volumetric data generated by current medical imaging techniques in the context of an increasing demand for long term archiving solutions, as well as the rapid development of distant radiology make the use of compression inevitable. Indeed, if the medical community has sided until now with compression without losses, most of applications suffer from compression ratios which are too low with this kind of compression. In this context, compression with acceptable losses could be the most appropriate answer. So, we propose a new loss coding scheme based on 3D (3 dimensional) Wavelet Transform and Dead Zone Lattice Vector Quantization 3D (DZLVQ) for medical images. Our algorithm has been evaluated on several computerized tomography (CT) and magnetic resonance image volumes. The main contribution of this work is the design of a multidimensional dead zone which enables to take into account correlations between neighbouring elementary volumes. At high compression ratios, we show that it can out-perform visually and numerically the best existing methods. These promising results are confirmed on head CT by two medical patricians. The second contribution of this document assesses the effect with-loss image compression on CAD (Computer-Aided Decision) detection performance of solid lung nodules. This work on 120 significant lungs images shows that detection did not suffer until 48:1 compression and still was robust at 96:1. The last contribution consists in the complexity reduction of our compression scheme. The first allocation dedicated to 2D DZLVQ uses an exponential of the rate-distortion (R-D) functions. The second allocation for 2D and 3D medical images is based on block statistical model to estimate the R-D curves. These R-D models are based on the joint distribution of wavelet vectors using a multidimensional mixture of generalized Gaussian (MMGG) densities. (author)

High-resolution high-sensitivity elemental imaging by secondary ion mass spectrometry: from traditional 2D and 3D imaging to correlative microscopy

International Nuclear Information System (INIS)

Wirtz, T; Philipp, P; Audinot, J-N; Dowsett, D; Eswara, S

2015-01-01

Secondary ion mass spectrometry (SIMS) constitutes an extremely sensitive technique for imaging surfaces in 2D and 3D. Apart from its excellent sensitivity and high lateral resolution (50 nm on state-of-the-art SIMS instruments), advantages of SIMS include high dynamic range and the ability to differentiate between isotopes. This paper first reviews the underlying principles of SIMS as well as the performance and applications of 2D and 3D SIMS elemental imaging. The prospects for further improving the capabilities of SIMS imaging are discussed. The lateral resolution in SIMS imaging when using the microprobe mode is limited by (i) the ion probe size, which is dependent on the brightness of the primary ion source, the quality of the optics of the primary ion column and the electric fields in the near sample region used to extract secondary ions; (ii) the sensitivity of the analysis as a reasonable secondary ion signal, which must be detected from very tiny voxel sizes and thus from a very limited number of sputtered atoms; and (iii) the physical dimensions of the collision cascade determining the origin of the sputtered ions with respect to the impact site of the incident primary ion probe. One interesting prospect is the use of SIMS-based correlative microscopy. In this approach SIMS is combined with various high-resolution microscopy techniques, so that elemental/chemical information at the highest sensitivity can be obtained with SIMS, while excellent spatial resolution is provided by overlaying the SIMS images with high-resolution images obtained by these microscopy techniques. Examples of this approach are given by presenting in situ combinations of SIMS with transmission electron microscopy (TEM), helium ion microscopy (HIM) and scanning probe microscopy (SPM). (paper)

Large-scale demonstration of D ampersand D technologies

International Nuclear Information System (INIS)

Bhattacharyya, S.K.; Black, D.B.; Rose, R.W.

1997-01-01

It is becoming increasingly evident that new technologies will need to be utilized for decontamination and decommissioning (D ampersand D) activities in order to assure safe and cost effective operations. The magnitude of the international D ampersand D problem is sufficiently large in anticipated cost (100's of billions of dollars) and in elapsed time (decades), that the utilization of new technologies should lead to substantial improvements in cost and safety performance. Adoption of new technologies in the generally highly contaminated D ampersand D environments requires assurances that the technology will perform as advertised. Such assurances can be obtained from demonstrations of the technology in environments that are similar to the actual environments without being quite as contaminated and hazardous. The Large Scale Demonstration Project (LSDP) concept was designed to provide such a function. The first LSDP funded by the U.S. Department Of Energy's Environmental Management Office (EM) was on the Chicago Pile 5 (CP-5) Reactor at Argonne National Laboratory. The project, conducted by a Strategic Alliance for Environmental Restoration, has completed demonstrations of 10 D ampersand D technologies and is in the process of comparing the performance to baseline technologies. At the conclusion of the project, a catalog of performance comparisons of these technologies will be developed that will be suitable for use by future D ampersand D planners

Ion cyclotron heating of JET D-D and D-T optimised shear plasmas

International Nuclear Information System (INIS)

Cottrell, G.; Baranov, Y.; Bartlett, D.

1998-12-01

This paper discusses the unique roles played by Ion Cyclotron Resonance Heating (ICRH) in the preparation, formation and sustainment of internal transport barriers (ITBs) in high fusion performance JET optimised shear experiments using the Mk. H poloidal divertor. Together with Lower Hybrid Current Drive (LHCD), low power ICRH is applied during the early ramp-up phase of the plasma current, 'freezing in' a hollow or flat current density profile with q(0)>1. In combination with up to ∼ 20 MW of Neutral Beam Injection (NBI), the ICRH power is stepped up to ∼ 6 MW during the main low confinement (L-mode) heating phase. An ITB forms promptly after the power step, revealed by a region of reduced central energy transport and peaked profiles, with the ion thermal diffusivity falling to values close to the standard neo-classical level near the centre of both D-D and D-T plasmas. At the critical time of ITB formation, the plasma contains an energetic ICRF hydrogen minority ion population, contributing ∼ 50% to the total plasma pressure and heating mainly electrons. As both the NBI population and the thermal ion pressure develop, a substantial part of the ICRF power is damped resonantly on core ions (ω = 2 ω cD = 3 ω cT ) contributing to the ion heating. In NBI step-down experiments, high performance has been sustained by maintaining central ICRH heating; analysis shows the efficiency of central ICRH ion heating to be comparable with that of NBI. The highest D-D fusion neutron rates (R NT = 5.6 x 10 16 s -1 ) yet achieved in JET plasmas have been produced by combining a low magnetic shear core with a high confinement (H-mode) edge. In D-T, a fusion triple product n i T i τ E = (1.2 ± 0.2) x 10 21 m -3 keVs was achieved with 7.2 MW of fusion power obtained in the L-mode and up to 8.2 MW of fusion power in the H-mode phase. (author)

SPADAS: a high-speed 3D single-photon camera for advanced driver assistance systems

Science.gov (United States)

Bronzi, D.; Zou, Y.; Bellisai, S.; Villa, F.; Tisa, S.; Tosi, A.; Zappa, F.

2015-02-01

Advanced Driver Assistance Systems (ADAS) are the most advanced technologies to fight road accidents. Within ADAS, an important role is played by radar- and lidar-based sensors, which are mostly employed for collision avoidance and adaptive cruise control. Nonetheless, they have a narrow field-of-view and a limited ability to detect and differentiate objects. Standard camera-based technologies (e.g. stereovision) could balance these weaknesses, but they are currently not able to fulfill all automotive requirements (distance range, accuracy, acquisition speed, and frame-rate). To this purpose, we developed an automotive-oriented CMOS single-photon camera for optical 3D ranging based on indirect time-of-flight (iTOF) measurements. Imagers based on Single-photon avalanche diode (SPAD) arrays offer higher sensitivity with respect to CCD/CMOS rangefinders, have inherent better time resolution, higher accuracy and better linearity. Moreover, iTOF requires neither high bandwidth electronics nor short-pulsed lasers, hence allowing the development of cost-effective systems. The CMOS SPAD sensor is based on 64 × 32 pixels, each able to process both 2D intensity-data and 3D depth-ranging information, with background suppression. Pixel-level memories allow fully parallel imaging and prevents motion artefacts (skew, wobble, motion blur) and partial exposure effects, which otherwise would hinder the detection of fast moving objects. The camera is housed in an aluminum case supporting a 12 mm F/1.4 C-mount imaging lens, with a 40°×20° field-of-view. The whole system is very rugged and compact and a perfect solution for vehicle's cockpit, with dimensions of 80 mm × 45 mm × 70 mm, and less that 1 W consumption. To provide the required optical power (1.5 W, eye safe) and to allow fast (up to 25 MHz) modulation of the active illumination, we developed a modular laser source, based on five laser driver cards, with three 808 nm lasers each. We present the full characterization of

3D Printing of Living Responsive Materials and Devices.

Science.gov (United States)

Liu, Xinyue; Yuk, Hyunwoo; Lin, Shaoting; Parada, German Alberto; Tang, Tzu-Chieh; Tham, Eléonore; de la Fuente-Nunez, Cesar; Lu, Timothy K; Zhao, Xuanhe

2018-01-01

3D printing has been intensively explored to fabricate customized structures of responsive materials including hydrogels, liquid-crystal elastomers, shape-memory polymers, and aqueous droplets. Herein, a new method and material system capable of 3D-printing hydrogel inks with programed bacterial cells as responsive components into large-scale (3 cm), high-resolution (30 μm) living materials, where the cells can communicate and process signals in a programmable manner, are reported. The design of 3D-printed living materials is guided by quantitative models that account for the responses of programed cells in printed microstructures of hydrogels. Novel living devices are further demonstrated, enabled by 3D printing of programed cells, including logic gates, spatiotemporally responsive patterning, and wearable devices. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Foreign acquisitions, domestic multinationals, and R&D

DEFF Research Database (Denmark)

Bandick, Roger; Görg, Holger; Karpaty, Patrik

2014-01-01

The aim of this paper is to evaluate the causal effect of foreign acquisition on R&D intensity in targeted domestic firms. We are able to distinguish domestic multinationals and non-multinationals, which allows us to investigate the fear that the change in ownership of domestic to foreign...... multinationals leads to a reduction in R&D activity in the country. We use unique and rich firm level data for the Swedish manufacturing sector and micro-econometric estimation strategies in order to control for the potential endogeneity of the acquisition decision. Overall, our results give no support...... to the fears that foreign acquisition of domestic firms lead to a relocation of R&D activity in Swedish MNEs. Rather, this paper finds robust evidence that foreign acquisitions lead to increasing R&D intensity in acquired domestic MNEs and non-MNEs....

The CARE accelerator R&D programme in Europe

CERN Document Server

Napoly, Olivier; den Ouden, Andres; Devred, Arnaud; Garoby, Roland; Garvey, Terence; Ghigo, Andrea; Gschwendtner, Edda; Losito, Roberto; Mais, Helmut; Palladino, V; Proch, Dieter; Richard, F; Rinolfi, Louis; Ruggiero, Francesco; Scandale, Walter; Schulte, Daniel; Vretenar, Maurizio

2005-01-01

CARE, an ambitious and coordinated programme of accelerator research and developments oriented towards high energy physics projects, has been launched in January 2004 by the main European laboratories and the European Commission. This project aims at improving existing infrastructures dedicated to future projects such as linear colliders, upgrades of hadron colliders and high intensity proton drivers. We describe the CARE R&D plans, mostly devoted to advancing the performance of the superconducting technology, both in the fields of RF cavities for electron or proton acceleration and of high field magnets, as well as to developing high intensity electron and proton injectors. We highlight some results and progress obtained so far.

High-speed 3D surface measurement with mechanical projector

Science.gov (United States)

Hyun, Jae-Sang; Zhang, Song

2017-05-01

This paper presents a method to overcome the light spectral range limitation of using digital-light-processing (DLP) projector for 3D shape measurement by developing a mechanical projector. The mechanical projector enables much broader spectral range of light than that the DLP projector allows. The rapidly spinning disk with binary structures can generate desired sinusoidal patterns at a frequency of 10 kHz or higher with a single DC motor. By precisely synchronizing the camera with the projector, phase-shifted fringe patterns can be accurately captured for high-accuracy 3D shape measurement. We further employed a computational framework that could enable absolute phase and thus absolute 3D shape measurement. We developed such prototype system that experimentally demonstrated the success of the proposed method.

High-Intensity Interval or Continuous-Moderate Exercise: A 24-Week Pilot Trial.

Science.gov (United States)

Locke, Sean R; Bourne, Jessica E; Beauchamp, Mark R; Little, Jonathan P; Barry, Julianne; Singer, Joel; Jung, Mary E

2018-05-14

High-intensity interval training (HIIT) may lead to superior cardiometabolic improvements when compared to moderate-intensity continuous training (MICT). However, adherence to HIIT requires examination. The purpose of this pilot study was to examine moderate-to-vigorous physical activity (MVPA) adherence 24 weeks following a brief counselling intervention combined with either HIIT or MICT. Individuals at high risk of type 2 diabetes (T2D) were randomized to HIIT (n = 15) or MICT (n = 17) and completed 10 exercise sessions accompanied by a brief 10-minute counselling intervention over a 2-week period. Objectively measured purposeful MVPA (accelerometry) and cardiorespiratory fitness (VO2peak) were assessed at baseline and 24 weeks post-intervention. Self-regulatory efficacy and task self-efficacy were examined at baseline, post-intervention and 24 weeks post-intervention. Using an intention-to-treat analysis, change scores were calculated for HIIT and MICT and compared between groups. Individuals assigned to HIIT increased their MVPA by 53 minutes (Cohen's d=1.52) at 24 weeks compared to 19 minutes in MICT (tbetween=1.96, p=.06, d =.56). Both HIIT and MICT increased relative VO2peak by 2 and 1 ml/kg/min, respectively (tbetween=0.72, p=0.47). Participants in both groups increased in their self-regulatory and task self-efficacy post-intervention but both groups demonstrated similar decline at 24 weeks. This pilot intervention was successful in increasing, and maintaining, free-living MVPA over a 24-week period in individuals at high risk of T2D. Speculation that HIIT is inappropriate or unattainable for overweight individuals at high risk of T2D may be unfounded.

Low-amplitude clustering in low-redshift 21-cm intensity maps cross-correlated with 2dF galaxy densities

Science.gov (United States)

Anderson, C. J.; Luciw, N. J.; Li, Y.-C.; Kuo, C. Y.; Yadav, J.; Masui, K. W.; Chang, T.-C.; Chen, X.; Oppermann, N.; Liao, Y.-W.; Pen, U.-L.; Price, D. C.; Staveley-Smith, L.; Switzer, E. R.; Timbie, P. T.; Wolz, L.

2018-05-01

We report results from 21-cm intensity maps acquired from the Parkes radio telescope and cross-correlated with galaxy maps from the 2dF galaxy survey. The data span the redshift range 0.057 clustering of neutral hydrogen (H I), a small correlation coefficient between optical galaxies and H I, or some combination of the two. Separating 2dF into red and blue galaxies, we find that red galaxies are much more weakly correlated with H I on k ˜ 1.5 h Mpc-1 scales, suggesting that H I is more associated with blue star-forming galaxies and tends to avoid red galaxies.

Studies of the 198Hg(d,d') and 198Hg(d,p) reactions

Science.gov (United States)

Diaz Varela, Alejandra; Garrett, P. E.; Rand, E. T.; Ball, G. C.; Bilstein, V.; Laffoley, A. T.; Maclean, A. D.; Svensson, C. E.; Faestermann, T.; Hertenberger, R.; Wirth, H.-F.

2017-09-01

Limits on the electric dipole moment (EDM) continue to decrease for 199Hg, the most stringent upper limit for a nuclear EDM to date. The experimental limit on the observed atomic EDM for 199Hg is converted to a limit on the nuclear EDM via a calculation of the Schiff moment, requiring knowledge of the nuclear structure of 199Hg. The E 3 and E 1 strength distributions to the ground state of 199Hg, and E 2 transitions amongst excited states, would be ideal information to further constrain 199Hg Schiff moment theoretical models. The high level density of 199Hg makes those determinations challenging, however the similar information can be obtained from exploring surrounding even-even Hg isotopes. As part of a campaign to study the Hg isotopes near 199Hg, two experiments, 198Hg(d,d') 198Hg and 198Hg(d,p)199Hg reaction were performed using the Q3D spectrograph at the Maier-Leibnitz Laboratory (MLL) at Garching, Germany. A 22 MeV deuterium beam was used to impinge a 198Hg32S target. The (d,d') reaction allows us to probe the desired E 2 and E 3 matrix elements, while the (d,p) reaction provides information on the neutron single-particle states of 199Hg.

No effect of glycogen level on glycogen metabolism during high intensity exercise

DEFF Research Database (Denmark)

Vandenberghe, Katleen; Hespel, P.; Eynde, Bart Vanden

1995-01-01

, either for 1 min 45 s (protocol 1; N = 18) or to exhaustion (protocol 2; N = 14). The exercise tests were preceded by either 5 d on a controlled normal (N) diet, or by 2 d of glycogen-depleting exercise accompanied by the normal diet followed by 3 d on a carbohydrate-rich (CHR) diet. In protocol 1......This study examined the effect of glycogen supercompensation on glycogen breakdown, muscle and blood lactate accumulation, blood-pH, and performance during short-term high-intensity exercise. Young healthy volunteers performed two supramaximal (125% of VO2max) exercise tests on a bicycle ergometer...

High-Intensity Exercise as a Dishabituating Stimulus Restores Counterregulatory Responses in Recurrently Hypoglycemic Rodents.

Science.gov (United States)

McNeilly, Alison D; Gallagher, Jennifer R; Huang, Jeffrey T-J; Ashford, Michael L J; McCrimmon, Rory J

2017-06-01

Hypoglycemia is a major adverse effect of insulin therapy for people with type 1 diabetes (T1D). Profound defects in the normal counterregulatory response to hypoglycemia explain the frequency of hypoglycemia occurrence in T1D. Defective counterregulation results to a large extent from prior exposure to hypoglycemia per se, leading to a condition called impaired awareness of hypoglycemia (IAH), the cause of which is unknown. In the current study, we investigate the hypothesis that IAH develops through a special type of adaptive memory referred to as habituation. To test this hypothesis, we used a novel intense stimulus (high-intensity exercise) to demonstrate two classic features of a habituated response, namely dishabituation and response recovery. We demonstrate that after recurrent hypoglycemia the introduction of a novel dishabituating stimulus (a single burst of high-intensity exercise) in male Sprague-Dawley rats restores the defective hypoglycemia counterregulatory response. In addition, the rats showed an enhanced response to the novel stimulus (response recovery). We make the further observation using proteomic analysis of hypothalamic extracts that high-intensity exercise in recurrently hypoglycemic rats increases levels of a number of proteins linked with brain-derived neurotrophic factor signaling. These findings may lead to novel therapeutic approaches for individuals with T1D and IAH. © 2017 by the American Diabetes Association.

WE-D-BRA-05: Pseudo In Vivo Patient Dosimetry Using a 3D-Printed Patient-Specific Phantom

International Nuclear Information System (INIS)

Ger, R; Craft, DF; Burgett, EA; Price, RR; Kry, SF; Howell, RM

2015-01-01

Purpose: To test the feasibility of using 3D-printed patient-specific phantoms for intensity-modulated radiation therapy (IMRT) quality assurance (QA). Methods: We created a patient-specific whole-head phantom using a 3D printer. The printer data file was created from high-resolution DICOM computed tomography (CT) images of 3-year old child treated at our institution for medulloblastoma. A custom-modified extruder system was used to create tissue-equivalent materials. For the printing process, the Hounsfield Units from the CT images were converted to proportional volumetric densities. A 5-field IMRT plan was created from the patient CT and delivered to the 3D- phantom. Dose was measured by an ion chamber placed through the eye. The ion chamber was placed at the posterior edge of the planning target volume in a high dose gradient region. CT scans of the patient and 3D-phantom were fused by using commercial treatment planning software (TPS). The patient’s plan was calculated on the phantom CT images. The ion chamber’s active volume was delineated in the TPS; dose per field and total dose were obtained. Measured and calculated doses were compared. Results: The 3D-phantom dimensions and tissue densities were in good agreement with the patient. However, because of a printing error, there was a large discrepancy in the density in the frontal cortex. The calculated and measured treatment plan doses were 1.74 Gy and 1.72 Gy, respectively. For individual fields, the absolute dose difference between measured and calculated values was on average 3.50%. Conclusion: This study demonstrated the feasibility of using 3D-printed patient-specific phantoms for IMRT QA. Such phantoms would be particularly advantageous for complex IMRT treatment plans featuring high dose gradients and/or for anatomical sites with high variation in tissue densities. Our preliminary findings are promising. We anticipate that, once the printing process is further refined, the agreement between

WE-D-BRA-05: Pseudo In Vivo Patient Dosimetry Using a 3D-Printed Patient-Specific Phantom

Energy Technology Data Exchange (ETDEWEB)

Ger, R; Craft, DF [The University of Texas Graduate School of Biomedical Sciences (United States); Burgett, EA [Idaho State University, Pocatello, idaho (United States); Price, RR [RANDJ Consulting, Frederick, MD (United States); Kry, SF; Howell, RM [The University of Texas Graduate School of Biomedical Sciences (United States); The University of Texas MD Anderson Cancer Ctr., Houston, TX (United States)

2015-06-15

Purpose: To test the feasibility of using 3D-printed patient-specific phantoms for intensity-modulated radiation therapy (IMRT) quality assurance (QA). Methods: We created a patient-specific whole-head phantom using a 3D printer. The printer data file was created from high-resolution DICOM computed tomography (CT) images of 3-year old child treated at our institution for medulloblastoma. A custom-modified extruder system was used to create tissue-equivalent materials. For the printing process, the Hounsfield Units from the CT images were converted to proportional volumetric densities. A 5-field IMRT plan was created from the patient CT and delivered to the 3D- phantom. Dose was measured by an ion chamber placed through the eye. The ion chamber was placed at the posterior edge of the planning target volume in a high dose gradient region. CT scans of the patient and 3D-phantom were fused by using commercial treatment planning software (TPS). The patient’s plan was calculated on the phantom CT images. The ion chamber’s active volume was delineated in the TPS; dose per field and total dose were obtained. Measured and calculated doses were compared. Results: The 3D-phantom dimensions and tissue densities were in good agreement with the patient. However, because of a printing error, there was a large discrepancy in the density in the frontal cortex. The calculated and measured treatment plan doses were 1.74 Gy and 1.72 Gy, respectively. For individual fields, the absolute dose difference between measured and calculated values was on average 3.50%. Conclusion: This study demonstrated the feasibility of using 3D-printed patient-specific phantoms for IMRT QA. Such phantoms would be particularly advantageous for complex IMRT treatment plans featuring high dose gradients and/or for anatomical sites with high variation in tissue densities. Our preliminary findings are promising. We anticipate that, once the printing process is further refined, the agreement between

Gamma diagnostics of thermonuclear plasma using D(d, gamma)4He reaction: Feasibility study

International Nuclear Information System (INIS)

Robouch, B.V.; Brzosko, J.S.; Ingrosso, L.

1993-01-01

Recent measurements of the D(d, Y) 4 He (Ey=25 MeV) reaction cross-section at low energies indicate values about 3 orders of magnitude higher than those obtained through extrapolations of previous experimental data. The new information triggers interest in the use of 25 MeV photons for diagnostics of fusion plasma. Both the spectral broadening of the neutron emission from the D(d, n)-reaction and that of the of the 25 MeV Gamma line offer two sensitive methods for the measurement of plasma temperature. Implementing this method presents an advantage over the classical neutron spectra broadening ((d, n)-branch) since it is simpler, more compact and cheaper. Moreover, once the necessary enhancement of the Y/n ratio is ensured, other complementary Y-diagnostics (under intense neutron fluxes) become possible. A preliminary version of such a system was developed using the 3D-MCSC-RWR subroutine complex of Monte Carlo random walk. The detecting system, composed of a HPGe-detector surrounded by a multilayer shield, appears to be very promising

2D or Not 2D? Testing the Utility of 2D Vs. 3D Landmark Data in Geometric Morphometrics of the Sculpin Subfamily Oligocottinae (Pisces; Cottoidea).

Science.gov (United States)

Buser, Thaddaeus J; Sidlauskas, Brian L; Summers, Adam P

2018-05-01

We contrast 2D vs. 3D landmark-based geometric morphometrics in the fish subfamily Oligocottinae by using 3D landmarks from CT-generated models and comparing the morphospace of the 3D landmarks to one based on 2D landmarks from images. The 2D and 3D shape variables capture common patterns across taxa, such that the pairwise Procrustes distances among taxa correspond and the trends captured by principal component analysis are similar in the xy plane. We use the two sets of landmarks to test several ecomorphological hypotheses from the literature. Both 2D and 3D data reject the hypothesis that head shape correlates significantly with the depth at which a species is commonly found. However, in taxa where shape variation in the z-axis is high, the 2D shape variables show sufficiently strong distortion to influence the outcome of the hypothesis tests regarding the relationship between mouth size and feeding ecology. Only the 3D data support previous studies which showed that large mouth sizes correlate positively with high percentages of elusive prey in the diet. When used to test for morphological divergence, 3D data show no evidence of divergence, while 2D data show that one clade of oligocottines has diverged from all others. This clade shows the greatest degree of z-axis body depth within Oligocottinae, and we conclude that the inability of the 2D approach to capture this lateral body depth causes the incongruence between 2D and 3D analyses. Anat Rec, 301:806-818, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

D and D technology development program

International Nuclear Information System (INIS)

Hyde, J.M.

1998-01-01

This paper describes the content of the current program of work for the Deactivation and Decommissioning Focus Area (DDFA) located in the Office of Science and Technology (EM-50). The authors began using large-scale demonstration projects (LSDPs) in 1996 to demonstrate and test innovative decommissioning and decontamination (D and D) technologies in ongoing US Department of Energy (DOE) decommissioning projects. These LSDPs have been conducted in and are planned for different types of DOE facilities such as research and production reactors; highly enriched uranium, tritium, and plutonium processing facilities; fuel reprocessing canyons; weapons production facilities; gaseous diffusion plants; hot cells; and waste processing facilities. The concept has been to focus on addressing DOE's high-priority deactivation and decommissioning needs through the LSDP strategy. In an LSDP, the focus area demonstrates improved technologies side by side with the current baseline technologies in ongoing site decommissioning projects. This approach helps reduce the risk and liability for the DOE users associated with the first-time use of a technology and promotes creative solutions that expand the D and D tool box beyond standard practices and technologies along with other benefits. As of January 1998, more than 50 technologies have been demonstrated covering the areas of characterization, decontamination, dismantlement, waste disposition, stabilization, and health and safety

Computer assisted determination of acetabular cup orientation using 2D-3D image registration

International Nuclear Information System (INIS)

Zheng, Guoyan; Zhang, Xuan

2010-01-01

2D-3D image-based registration methods have been developed to measure acetabular cup orientation after total hip arthroplasty (THA). These methods require registration of both the prosthesis and the CT images to 2D radiographs and compute implant position with respect to a reference. The application of these methods is limited in clinical practice due to two limitations: (1) the requirement of a computer-aided design (CAD) model of the prosthesis, which may be unavailable due to the proprietary concerns of the manufacturer, and (2) the requirement of either multiple radiographs or radiograph-specific calibration, usually unavailable for retrospective studies. In this paper, we propose a new method to address these limitations. A new formulation for determination of post-operative cup orientation, which couples a radiographic measurement with 2D-3D image matching, was developed. In our formulation, the radiographic measurement can be obtained with known methods so that the challenge lies in the 2D-3D image matching. To solve this problem, a hybrid 2D-3D registration scheme combining a landmark-to-ray 2D-3D alignment with a robust intensity-based 2D-3D registration was used. The hybrid 2D-3D registration scheme allows computing both the post-operative cup orientation with respect to an anatomical reference and the pelvic tilt and rotation with respect to the X-ray imaging table/plate. The method was validated using 2D adult cadaver hips. Using the hybrid 2D-3D registration scheme, our method showed a mean accuracy of 1.0 ± 0.7 (range from 0.1 to 2.0 ) for inclination and 1.7 ± 1.2 (range from 0.0 to 3.9 ) for anteversion, taking the measurements from post-operative CT images as ground truths. Our new solution formulation and the hybrid 2D-3D registration scheme facilitate estimation of post-operative cup orientation and measurement of pelvic tilt and rotation. (orig.)

3D high-resolution two-photon crosslinked hydrogel structures for biological studies.

Science.gov (United States)

Brigo, Laura; Urciuolo, Anna; Giulitti, Stefano; Della Giustina, Gioia; Tromayer, Maximilian; Liska, Robert; Elvassore, Nicola; Brusatin, Giovanna

2017-06-01

Hydrogels are widely used as matrices for cell growth due to the their tuneable chemical and physical properties, which mimic the extracellular matrix of natural tissue. The microfabrication of hydrogels into arbitrarily complex 3D structures is becoming essential for numerous biological applications, and in particular for investigating the correlation between cell shape and cell function in a 3D environment. Micrometric and sub-micrometric resolution hydrogel scaffolds are required to deeply investigate molecular mechanisms behind cell-matrix interaction and downstream cellular processes. We report the design and development of high resolution 3D gelatin hydrogel woodpile structures by two-photon crosslinking. Hydrated structures of lateral linewidth down to 0.5µm, lateral and axial resolution down to a few µm are demonstrated. According to the processing parameters, different degrees of polymerization are obtained, resulting in hydrated scaffolds of variable swelling and deformation. The 3D hydrogels are biocompatible and promote cell adhesion and migration. Interestingly, according to the polymerization degree, 3D hydrogel woodpile structures show variable extent of cell adhesion and invasion. Human BJ cell lines show capability of deforming 3D micrometric resolved hydrogel structures. The design and development of high resolution 3D gelatin hydrogel woodpile structures by two-photon crosslinking is reported. Significantly, topological and mechanical conditions of polymerized gelatin structures were suitable for cell accommodation in the volume of the woodpiles, leading to a cell density per unit area comparable to the bare substrate. The fabricated structures, presenting micrometric features of high resolution, are actively deformed by cells, both in terms of cell invasion within rods and of cell attachment in-between contiguous woodpiles. Possible biological targets for this 3D approach are customized 3D tissue models, or studies of cell adhesion

Comparison of preliminary D-T and ''catalyzed'' D-D system studies

International Nuclear Information System (INIS)

Usher, J.L.; Powell, J.R.; Fillo, J.A.; Lazareth, O.W.

1976-01-01

The purpose of the research currently underway is to provide technological and eventual economic comparison of a reference D-T reactor to a ''catalyzed'' D-D reactor. Two separate reactor designs are delineated and examined for this purpose. These systems include plasma parameters, blanket and shield configurations, magnetic coil configurations, and power conversion systems, including a divertor-direct convertor system for the D-D design. The initial conclusions reached are as follows: (a) no extraordinary requirements in the D-D reactor in the areas of blanket or magnet technology, (b) advantageous use of minimum activity blankets and shields, (c) increased overall efficiency via introduction of divertor-direct convertor subsystem in D-D design and (d) 65 percent increase in the toroidal radius of the D-D design compared to the D-T reference value

Potencies of vitamin D analogs, 1α-hydroxyvitamin D3 , 1α-hydroxyvitamin D2 and 25-hydroxyvitamin D3 , in lowering cholesterol in hypercholesterolemic mice in vivo.

Science.gov (United States)

Quach, Holly P; Dzekic, Tamara; Bukuroshi, Paola; Pang, K Sandy

2018-04-01

Vitamin D 3 and the synthetic vitamin D analogs, 1α-hydroxyvitamin D 3 [1α(OH)D 3 ], 1α-hydroxyvitamin D 2 [1α(OH)D 2 ] and 25-hydroxyvitamin D 3 [25(OH)D 3 ] were appraised for their vitamin D receptor (VDR) associated-potencies as cholesterol lowering agents in mice in vivo. These precursors are activated in vivo: 1α(OH)D 3 and 1α(OH)D 2 are transformed by liver CYP2R1 and CYP27A1 to active VDR ligands, 1α,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] and 1α,25-dihydroxyvitamin D 2 [1,25(OH) 2 D 2 ] , respectively. 1α(OH)D 2 may also be activated by CYP24A1 to 1α,24-dihydroxyvitamin D 2 [1,24(OH) 2 D 2 ], another active VDR ligand. 25(OH)D 3 , the metabolite formed via CYP2R1 and or CYP27A1 in liver from vitamin D 3 , is activated by CYP27B1 in the kidney to 1,25(OH) 2 D 3 . In C57BL/6 mice fed the high fat/high cholesterol Western diet for 3 weeks, vitamin D analogs were administered every other day intraperitoneally during the last week of the diet. The rank order for cholesterol lowering, achieved via mouse liver small heterodimer partner (Shp) inhibition and increased cholesterol 7α-hydroxylase (Cyp7a1) expression, was: 1.75 nmol/kg 1α(OH)D 3  > 1248 nmol/kg 25(OH)D 3 (dose ratio of 0.0014) > > 1625 nmol/kg vitamin D 3 . Except for 1.21 nmol/kg 1α(OH)D 2 that failed to lower liver and plasma cholesterol contents, a significant negative correlation was observed between the liver concentration of 1,25(OH) 2 D 3 formed from the precursors and liver cholesterol levels. The composite results show that vitamin D analogs 1α(OH)D 3 and 25(OH)D 3 exhibit cholesterol lowering properties upon activation to 1,25(OH) 2 D 3 : 1α(OH)D 3 is rapidly activated by liver enzymes and 25(OH)D 3 is slowly activated by renal Cyp27b1 in mouse. Copyright © 2018 John Wiley & Sons, Ltd.

High Performance Implementation of 3D Convolutional Neural Networks on a GPU

Science.gov (United States)

Wang, Zelong; Wen, Mei; Zhang, Chunyuan; Wang, Yijie

2017-01-01

Convolutional neural networks have proven to be highly successful in applications such as image classification, object tracking, and many other tasks based on 2D inputs. Recently, researchers have started to apply convolutional neural networks to video classification, which constitutes a 3D input and requires far larger amounts of memory and much more computation. FFT based methods can reduce the amount of computation, but this generally comes at the cost of an increased memory requirement. On the other hand, the Winograd Minimal Filtering Algorithm (WMFA) can reduce the number of operations required and thus can speed up the computation, without increasing the required memory. This strategy was shown to be successful for 2D neural networks. We implement the algorithm for 3D convolutional neural networks and apply it to a popular 3D convolutional neural network which is used to classify videos and compare it to cuDNN. For our highly optimized implementation of the algorithm, we observe a twofold speedup for most of the 3D convolution layers of our test network compared to the cuDNN version. PMID:29250109

High Performance Implementation of 3D Convolutional Neural Networks on a GPU.

Science.gov (United States)

Lan, Qiang; Wang, Zelong; Wen, Mei; Zhang, Chunyuan; Wang, Yijie

2017-01-01

Convolutional neural networks have proven to be highly successful in applications such as image classification, object tracking, and many other tasks based on 2D inputs. Recently, researchers have started to apply convolutional neural networks to video classification, which constitutes a 3D input and requires far larger amounts of memory and much more computation. FFT based methods can reduce the amount of computation, but this generally comes at the cost of an increased memory requirement. On the other hand, the Winograd Minimal Filtering Algorithm (WMFA) can reduce the number of operations required and thus can speed up the computation, without increasing the required memory. This strategy was shown to be successful for 2D neural networks. We implement the algorithm for 3D convolutional neural networks and apply it to a popular 3D convolutional neural network which is used to classify videos and compare it to cuDNN. For our highly optimized implementation of the algorithm, we observe a twofold speedup for most of the 3D convolution layers of our test network compared to the cuDNN version.

3D Modeling Activity for Novel High Power Electron Guns at SLAC

International Nuclear Information System (INIS)

Krasnykh, Anatoly

2003-01-01

The next generation of powerful electronic devices requires new approaches to overcome the known limitations of existing tube technology. Multi-beam and sheet beam approaches are novel concepts for the high power microwave devices. Direct and indirect modeling methods are being developed at SLAC to meet the new requirements in the 3D modeling. The direct method of solving of Poisson's equations for the multi-beam and sheet beam guns is employed in the TOPAZ 3D tool. The combination of TOPAZ 2D and EGUN (in the beginning) with MAFIA 3D and MAGIC 3D (at the end) is used in an indirect method to model the high power electron guns. Both methods complement each other to get reliable representation of the beam trajectories. Several gun ideas are under consideration at the present time. The collected results of these simulations are discussed

3D Modeling Activity for Novel High Power Electron Guns at SLAC

CERN Document Server

Krasnykh, Anatoly K

2003-01-01

The next generation of powerful electronic devices requires new approaches to overcome the known limitations of existing tube technology. Multi-beam and sheet beam approaches are novel concepts for the high power microwave devices. Direct and indirect modeling methods are being developed at SLAC to meet the new requirements in the 3D modeling. The direct method of solving of Poisson's equations for the multi-beam and sheet beam guns is employed in the TOPAZ 3D tool. The combination of TOPAZ 2D and EGUN (in the beginning) with MAFIA 3D and MAGIC 3D (at the end) is used in an indirect method to model the high power electron guns. Both methods complement each other to get reliable representation of the beam trajectories. Several gun ideas are under consideration at the present time. The collected results of these simulations are discussed.

Anisotropic 3D texture synthesis with application to volume rendering

DEFF Research Database (Denmark)

Laursen, Lasse Farnung; Ersbøll, Bjarne Kjær; Bærentzen, Jakob Andreas

2011-01-01

images using a 12.1 megapixel camera. Next, we extend the volume rendering pipeline by creating a transfer function which yields not only color and opacity from the input intensity, but also texture coordinates for our synthesized 3D texture. Thus, we add texture to the volume rendered images....... This method is applied to a high quality visualization of a pig carcass, where samples of meat, bone, and fat have been used to produce the anisotropic 3D textures....

Infra Red 3D Computer Mouse

DEFF Research Database (Denmark)

Harbo, Anders La-Cour; Stoustrup, Jakob

2000-01-01

The infra red 3D mouse is a three dimensional input device to a computer. It works by determining the position of an arbitrary object (like a hand) by emitting infra red signals from a number of locations and measuring the reflected intensities. To maximize stability, robustness, and use of bandw......The infra red 3D mouse is a three dimensional input device to a computer. It works by determining the position of an arbitrary object (like a hand) by emitting infra red signals from a number of locations and measuring the reflected intensities. To maximize stability, robustness, and use...

Photo-Detection on Narrow-Bandgap High-Mobility 2D Semiconductors

Science.gov (United States)

Charnas, Adam; Qiu, Gang; Deng, Yexin; Wang, Yixiu; Du, Yuchen; Yang, Lingming; Wu, Wenzhuo; Ye, Peide

Photo-detection and energy harvesting device concepts have been demonstrated widely in 2D materials such as graphene, TMDs, and black phosphorus. In this work, we demonstrate anisotropic photo-detection achieved using devices fabricated from hydrothermally grown narrow-bandgap high-mobility 2D semiconductor. Back-gated FETs were fabricated by transferring the 2D flakes onto a Si/SiO2 substrate and depositing various metal contacts across the flakes to optimize the access resistance for optoelectronic devices. Photo-responsivity was measured and mapped by slightly biasing the devices and shining a laser spot at different locations of the device to observe and map the resulting photo-generated current. Optimization of the Schottky barrier height for both n and p at the metal-2D interfaces using asymmetric contact engineering was performed to improve device performance.

GPU accelerated generation of digitally reconstructed radiographs for 2-D/3-D image registration.

Science.gov (United States)

Dorgham, Osama M; Laycock, Stephen D; Fisher, Mark H

2012-09-01

Recent advances in programming languages for graphics processing units (GPUs) provide developers with a convenient way of implementing applications which can be executed on the CPU and GPU interchangeably. GPUs are becoming relatively cheap, powerful, and widely available hardware components, which can be used to perform intensive calculations. The last decade of hardware performance developments shows that GPU-based computation is progressing significantly faster than CPU-based computation, particularly if one considers the execution of highly parallelisable algorithms. Future predictions illustrate that this trend is likely to continue. In this paper, we introduce a way of accelerating 2-D/3-D image registration by developing a hybrid system which executes on the CPU and utilizes the GPU for parallelizing the generation of digitally reconstructed radiographs (DRRs). Based on the advancements of the GPU over the CPU, it is timely to exploit the benefits of many-core GPU technology by developing algorithms for DRR generation. Although some previous work has investigated the rendering of DRRs using the GPU, this paper investigates approximations which reduce the computational overhead while still maintaining a quality consistent with that needed for 2-D/3-D registration with sufficient accuracy to be clinically acceptable in certain applications of radiation oncology. Furthermore, by comparing implementations of 2-D/3-D registration on the CPU and GPU, we investigate current performance and propose an optimal framework for PC implementations addressing the rigid registration problem. Using this framework, we are able to render DRR images from a 256×256×133 CT volume in ~24 ms using an NVidia GeForce 8800 GTX and in ~2 ms using NVidia GeForce GTX 580. In addition to applications requiring fast automatic patient setup, these levels of performance suggest image-guided radiation therapy at video frame rates is technically feasible using relatively low cost PC

Dissociation and ionization of molecular ions by ultra-short intense laser pulses probed by coincidence 3D momentum imaging

International Nuclear Information System (INIS)

Ben-Itzhak, Itzik; Wang, Pengqian; Xia, Jiangfan; Max Sayler, A.; Smith, Mark A.; Maseberg, J.W.; Carnes, Kevin D.; Esry, Brett D.

2005-01-01

We have experimentally explored laser-induced dissociation and ionization of diatomic molecular ions using coincidence 3D momentum imaging. The vibrationally excited molecular ion beam (4-8 keV) is crossed by an ultrafast intense laser beam (28-200 fs, 10 13 -10 14 W/cm 2 ). The resulting fragments are recorded in coincidence by a time and position-sensitive detector. Complete angular distributions and kinetic energy release maps are reconstructed from the measured dissociation-momentum vectors. The angular distribution of the H + + H fragments was found to be strongly correlated to their kinetic energy release upon dissociation. Low KER was associated with very narrow angular distributions and high KER with distributions peaking away from the laser polarization. Ionization was found to be smaller than dissociation and increased with laser intensity. The H + + H + fragments have a very narrow angular distribution along the laser polarization

A semi-automatic 2D-to-3D video conversion with adaptive key-frame selection

Science.gov (United States)

Ju, Kuanyu; Xiong, Hongkai

2014-11-01

To compensate the deficit of 3D content, 2D to 3D video conversion (2D-to-3D) has recently attracted more attention from both industrial and academic communities. The semi-automatic 2D-to-3D conversion which estimates corresponding depth of non-key-frames through key-frames is more desirable owing to its advantage of balancing labor cost and 3D effects. The location of key-frames plays a role on quality of depth propagation. This paper proposes a semi-automatic 2D-to-3D scheme with adaptive key-frame selection to keep temporal continuity more reliable and reduce the depth propagation errors caused by occlusion. The potential key-frames would be localized in terms of clustered color variation and motion intensity. The distance of key-frame interval is also taken into account to keep the accumulated propagation errors under control and guarantee minimal user interaction. Once their depth maps are aligned with user interaction, the non-key-frames depth maps would be automatically propagated by shifted bilateral filtering. Considering that depth of objects may change due to the objects motion or camera zoom in/out effect, a bi-directional depth propagation scheme is adopted where a non-key frame is interpolated from two adjacent key frames. The experimental results show that the proposed scheme has better performance than existing 2D-to-3D scheme with fixed key-frame interval.

Contributions in compression of 3D medical images and 2D images; Contributions en compression d'images medicales 3D et d'images naturelles 2D

Energy Technology Data Exchange (ETDEWEB)

Gaudeau, Y

2006-12-15

The huge amounts of volumetric data generated by current medical imaging techniques in the context of an increasing demand for long term archiving solutions, as well as the rapid development of distant radiology make the use of compression inevitable. Indeed, if the medical community has sided until now with compression without losses, most of applications suffer from compression ratios which are too low with this kind of compression. In this context, compression with acceptable losses could be the most appropriate answer. So, we propose a new loss coding scheme based on 3D (3 dimensional) Wavelet Transform and Dead Zone Lattice Vector Quantization 3D (DZLVQ) for medical images. Our algorithm has been evaluated on several computerized tomography (CT) and magnetic resonance image volumes. The main contribution of this work is the design of a multidimensional dead zone which enables to take into account correlations between neighbouring elementary volumes. At high compression ratios, we show that it can out-perform visually and numerically the best existing methods. These promising results are confirmed on head CT by two medical patricians. The second contribution of this document assesses the effect with-loss image compression on CAD (Computer-Aided Decision) detection performance of solid lung nodules. This work on 120 significant lungs images shows that detection did not suffer until 48:1 compression and still was robust at 96:1. The last contribution consists in the complexity reduction of our compression scheme. The first allocation dedicated to 2D DZLVQ uses an exponential of the rate-distortion (R-D) functions. The second allocation for 2D and 3D medical images is based on block statistical model to estimate the R-D curves. These R-D models are based on the joint distribution of wavelet vectors using a multidimensional mixture of generalized Gaussian (MMGG) densities. (author)

High Field Magnet R and D in the USA

International Nuclear Information System (INIS)

Gourlay, S.A.

2003-01-01

Accelerator magnet technology is currently dominated by the use of NbTi superconductor. New and more demanding applications for superconducting accelerator magnets require the use of alternative materials. Several programs in the US are taking advantage of recent improvements in Nb 3 Sn to develop high field magnets for new applications. Highlights and challenges of the US R and D program are presented along with the status of conductor development. In addition, a new R and D focus, the US LHC Accelerator Research Program, will be discussed.

High Field Magnet R and D in the USA

International Nuclear Information System (INIS)

Gourlay, Stephen A.

2003-01-01

Accelerator magnet technology is currently dominated by the use of NbTi superconductor. New and more demanding applications for superconducting accelerator magnets require the use of alternative materials. Several programs in the US are taking advantage of recent improvements in Nb 3 Sn to develop high field magnets for new applications. Highlights and challenges of the US R and D program are presented along with the status of conductor development. In addition, a new R and D focus, the US LHC Accelerator Research Program, will be discussed

High dose vitamin D may improve lower urinary tract symptoms in postmenopausal women.

Science.gov (United States)

Oberg, Johanna; Verelst, Margareta; Jorde, Rolf; Cashman, Kevin; Grimnes, Guri

2017-10-01

Lower urinary tract symptoms (LUTS) are common in postmenopausal women, and have been reported inversely associated with vitamin D intake and serum 25-hydroxyvitamin D (25(OH)D) levels. The aim of this study was to investigate if high dose vitamin D supplementation would affect LUTS in comparison to standard dose. In a randomized controlled study including 297 postmenopausal women with low bone mineral density, the participants were allocated to receive capsules of 20 000IU of vitamin D 3 twice a week (high dose group) or similar looking placebo (standard dose group). In addition, all the participants received 1g of calcium and 800IU of vitamin D daily. A validated questionnaire regarding LUTS was filled in at baseline and after 12 months. At baseline, 76 women in the high dose group and 82 in the standard dose group reported any LUTS. Levels of serum 25(OH)D increased significantly more in the high dose group (from 64.7 to 164.1nmol/l compared to from 64.1 to 81.8nmol/l, p<0.01). No differences between the groups were seen regarding change in LUTS except for a statistically significant reduction in the reported severity of urine incontinence in the high dose group as compared to the standard dose group after one year (p<0.05). The results need confirmation in a study specifically designed for this purpose. Copyright © 2017 Elsevier Ltd. All rights reserved.

anti B_d_,_s → D"*_d_,_sV and anti B"*_d_,_s → D_d_,_sV decays in QCD factorization and possible puzzles

International Nuclear Information System (INIS)

Chang, Qin; Chen, Ling-Xin; Zhang, Yun-Yun; Sun, Jun-Feng; Yang, Yue-Ling

2016-01-01

Motivated by the rapid development of heavy-flavor experiments, phenomenological studies of nonleptonic anti B_d_,_s → D"*_d_,_sV and anti B"*_d_,_s → D_d_,_sV (V = ρ, K*) decays are performed within the framework of QCD factorization. Relative to the previous work, the QCD corrections to the transverse amplitudes are evaluated at next-to-leading order. The theoretical predictions of the observables are updated. For the measured anti B_d_,_s → D"*_d_,_sV decays, the tensions between theoretical results and experimental measurements, i.e. the ''R_d_s"V puzzle'' and ''D*V (or R_V_/_l _a_n_t_i _ν__l_) puzzle'', are presented after detailed analyses. For the anti B"*_d_,_s → D_d_,_sV decays, they have relatively large branching fractions of the order >or similar O(10"-"9) and are in the scope of Belle-II and LHCb experiments. Moreover, they also provide a way to crosscheck the possible puzzles mentioned above through the similar ratios R_d_s"'"V and R"'_V_/_l _a_n_t_i _ν__l_. More refined experimental measurements and theoretical efforts are required to confirm or refute such two anomalies. (orig.)

Simultaneous analysis of D-alanine, D-aspartic acid, and D-serine using chiral high-performance liquid chromatography-tandem mass spectrometry and its application to the rat plasma and tissues.

Science.gov (United States)

Karakawa, Sachise; Shimbo, Kazutaka; Yamada, Naoyuki; Mizukoshi, Toshimi; Miyano, Hiroshi; Mita, Masashi; Lindner, Wolfgang; Hamase, Kenji

2015-11-10

A highly sensitive and selective chiral LC-MS/MS method for D-alanine, D-aspartic acid and D-serine has been developed using the precolumn derivatization reagents, 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AccQ-Tag) or p-N,N,N-trimethylammonioanilyl N'-hydroxysuccinimidyl carbamate iodide (TAHS). The thus N-tagged enantiomers of the derivatized amino acids were nicely separated within 20min using the cinchona alkaloid-based zwittterionic ion-exchange type enantioselective column, Chiralpak ZWIX(+). The selected reaction monitoring was applied for detecting the target d-amino acids in biological matrices. By using the present chiral LC-MS/MS method, the three d-amino acids and their l-forms could be simultaneously determined in the range of 0.1-500nmol/mL. Finally, the technique was successfully applied to rat plasma and tissue samples. Copyright © 2015 Elsevier B.V. All rights reserved.

Regime of very high confinement in the boronized DIII-D tokamak

International Nuclear Information System (INIS)

Jackson, G.L.; Winter, J.; Taylor, T.S.; Burrell, K.H.; DeBoo, J.C.; Greenfield, C.M.; Groebner, R.J.; Hodapp, T.; Holtrop, K.; Lazarus, E.A.; Lao, L.L.; Lippmann, S.I.; Osborne, T.H.; Petrie, T.W.; Phillips, J.; James, R.; Schissel, D.P.; Strait, E.J.; Turnbull, A.D.; West, W.P.; DIII-D Team

1991-01-01

Following boronization, tokamak discharges in DIII-D have been obtained with confinement times up to a factor of 3.5 above the ITER89-P L-mode scaling and 1.8 times greater than the DIII-D/JET H-mode scaling relation. Very high confinement phases are characterized by relatively high central density with n e (0)∼1x10 20 m -3 , and central ion temperatures up to 13.6 keV at moderate plasma currents (1.6 MA) and heating powers (12.5--15.3 MW). These discharges exhibit a low fraction of radiated power, P≤25%, Z eff (0) close to unity, and lower impurity influxes than comparable DIII-D discharges before boronization

Multispectroscopic methods reveal different modes of interaction of anti cancer drug mitoxantrone with Poly(dG-dC).Poly(dG-dC) and Poly(dA-dT).Poly(dA-dT).

Science.gov (United States)

Awasthi, Pamita; Dogra, Shilpa; Barthwal, Ritu

2013-10-05

The interaction of mitoxantrone with alternating Poly(dG-dC).Poly(dG-dC) and Poly(dA-dT).Poly(dA-dT) duplex has been studied by absorption, fluorescence and Circular Dichroism (CD) spectroscopy at Drug to Phosphate base pair ratios D/P=20.0-0.04. Binding to GC polymer occurs in two distinct modes: partial stacking characterized by red shifts of 18-23nm at D/P=0.2-0.8 and external binding at D/P=1.0-20.0 whereas that to AT polymer occurs externally in the entire range of D/P. The binding constant and number of binding sites is 3.7×10(5)M(-1), 0.3 and 1.3× 10(4)M(-1), 1.5 in GC and AT polymers, respectively at low D/P ratios. CD binding isotherms show breakpoints at D/P=0.1, 0.5 and 0.25, 0.5 in GC and AT polymers, respectively. The intrinsic CD bands indicate that the distortions in GC polymer are significantly higher than that in AT polymer. Docking studies show partial insertion of mitoxantrone rings between to GC base pairs in alternating GC polymer. Side chains of mitoxantrone interact specifically with base pairs and DNA backbone. The studies are relevant to the understanding of suppression or inhibition of DNA cleavage on formation of ternary complex with topoisomerase-II enzyme and hence the anti cancer action. Copyright © 2013 Elsevier B.V. All rights reserved.

Vitamin D derivatives

International Nuclear Information System (INIS)

Deluca, H.F.; Schnoes, H.K.; Napoli, J.L.; Fivizzani, M.A.

1982-01-01

The chemical preparation of 26,27-isotopically labelled vitamin D 3 derivatives of high specific activity is described. These labelled vitamin D derivatives are useful in the determination of vitamin D metabolite levels in the blood and tissues of man and animals. (U.K.)

Vitamin D-binding protein controls T cell responses to vitamin D

DEFF Research Database (Denmark)

Kongsbak, Martin; von Essen, Marina Rode; Levring, Trine Bøegh

2014-01-01

BACKGROUND: In vitro studies have shown that the active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), can regulate differentiation of CD4+ T cells by inhibiting Th1 and Th17 cell differentiation and promoting Th2 and Treg cell differentiation. However, the serum concentration of 1...... that activated T cells express the 25(OH)D-1α-hydroxylase CYP27B1 that converts 25(OH)D3 to 1,25(OH)2D3, it is still controversial whether activated T cells have the capacity to produce sufficient amounts of 1,25(OH)2D3 to affect vitamin D-responsive genes. Furthermore, it is not known how the vitamin D......-binding protein (DBP) found in high concentrations in serum affects T cell responses to 25(OH)D3. RESULTS: We found that activated T cells express CYP27B1 and have the capacity to produce sufficient 1,25(OH)2D3 to affect vitamin D-responsive genes when cultured with physiological concentrations of 25(OH)D3...

3D Stereoscopic Visualization of Fenestrated Stent Grafts

International Nuclear Information System (INIS)

Sun Zhonghua; Squelch, Andrew; Bartlett, Andrew; Cunningham, Kylie; Lawrence-Brown, Michael

2009-01-01

The purpose of this study was to present a technique of stereoscopic visualization in the evaluation of patients with abdominal aortic aneurysm treated with fenestrated stent grafts compared with conventional 2D visualizations. Two patients with abdominal aortic aneurysm undergoing fenestrated stent grafting were selected for inclusion in the study. Conventional 2D views including axial, multiplanar reformation, maximum-intensity projection, and volume rendering and 3D stereoscopic visualizations were assessed by two experienced reviewers independently with regard to the treatment outcomes of fenestrated repair. Interobserver agreement was assessed with Kendall's W statistic. Multiplanar reformation and maximum-intensity projection visualizations were scored the highest in the evaluation of parameters related to the fenestrated stent grafting, while 3D stereoscopic visualization was scored as valuable in the evaluation of appearance (any distortions) of the fenestrated stent. Volume rendering was found to play a limited role in the follow-up of fenestrated stent grafting. 3D stereoscopic visualization adds additional information that assists endovascular specialists to identify any distortions of the fenestrated stents when compared with 2D visualizations.

3D Simulations of NIF Wetted Foam Experiments to Understand the Transition from 2D to 3D Implosion Behavior

Science.gov (United States)

Haines, Brian; Olson, Richard; Yi, Austin; Zylstra, Alex; Peterson, Robert; Bradley, Paul; Shah, Rahul; Wilson, Doug; Kline, John; Leeper, Ramon; Batha, Steve

2017-10-01

The high convergence ratio (CR) of layered Inertial Confinement Fusion capsule implosions contribute to high performance in 1D simulations yet make them more susceptible to hydrodynamic instabilities, contributing to the development of 3D flows. The wetted foam platform is an approach to hot spot ignition to achieve low-to-moderate convergence ratios in layered implosions on the NIF unobtainable using an ice layer. Detailed high-resolution modeling of these experiments in 2D and 3D, including all known asymmetries, demonstrates that 2D hydrodynamics explain capsule performance at CR 12 but become less suitable as the CR increases. Mechanisms for this behavior and detailed comparisons of simulations to experiments on NIF will be presented. To evaluate the tradeoff between increased instability and improved 1D performance, we present a full-scale wetted foam capsule design with 17

Dopamine D/sub 2/ and D/sub 1/ receptors: biochemical characterization

Energy Technology Data Exchange (ETDEWEB)

Niznik, H B

1986-01-01

In order to label dopamine D/sub 2/ receptors reversibly and selectively the potent substituted benzamide neuroleptic, YM-09151-2, was tritium labeled and its binding characteristics to striatal homogenates investigated. (/sup 3/H) YM-09151-2 bound to D/sub 2/ receptors with high affinity in a specific, saturable, reversible and sodium dependent fashion, displaying an appropriate pharmacological D/sub 2/ receptor profile. (/sup 3/H) YM-09151-2 appears to be the ligand of choice for labeling D/sub 2/ receptors since it displays approximately 20-fold lower affinity for serotonergic S/sub 2/ receptors than does (/sup 3/H) spiperone. As an initial step towards the molecular identification of the ligand binding subunit of the striatal D/sub 2/ receptor, photolabile analogues of the substituted benzamide clebopride were synthesized and their reversible and irreversible binding interactions to D/sub 2/ receptors characterized. D/sub 2/ receptor photoinactivation was prevented in a concentration and stereoselective manner by dopaminergic agonists and antagonists. In vivo biodistribution studies with (/sup 125/I) iodoazidoclebopride confirmed the ligand's ability to bind to D/sub 2/ receptor-rich regions and as such, may become a useful tool for the molecular characterization of D/sub 2/ receptor proteins. Digitonin solubilized striatal dopamine D/sub 2/ and D/sub 1/ receptors can be completely separated with full retention of biological activity by steric exclusion High Pressure Liquid Chromatography (HPLC) with corresponding Stokes radii of 7.1 and 5.6 nm.

Efficacy and tolerability of a high loading dose (25,000 IU weekly) vitamin D3 supplementation in obese children with vitamin D insufficiency/deficiency

NARCIS (Netherlands)

Radhakishun, Nalini N E; van Vliet, Mariska; Poland, Dennis C W; Weijer, Olivier; Beijnen, Jos H; Brandjes, Dees P M; Diamant, Michaela; von Rosenstiel, Ines A

2014-01-01

BACKGROUND: The recommended dose of vitamin D supplementation of 400 IU/day might be inadequate to treat obese children with vitamin D insufficiency. Therefore, we tested the efficacy and tolerability of a high loading dose vitamin D3 supplementation of 25,000 IU weekly in multiethnic obese

Recent mathematical developments in 2D correlation spectroscopy

Science.gov (United States)

Noda, I.

2000-03-01

Recent mathematical developments in the field of 2D correlation spectroscopy, especially those related to the statistical theory, are reported. The notion of correlation phase angle is introduced. The significance of correlation phase angle between dynamic fluctuations of signals measured at two different spectral variables may be linked to more commonly known statistical concepts, such as coherence and correlation coefficient. This treatment provides the direct mathematical connection between the synchronous 2D correlation spectrum with a continuous form of the variance-covariance matrix. Moreover, it gives the background for the formal definition of the disrelation spectrum, which may be used as a heuristic substitution for the asynchronous 2D spectrum. The 2D correlation intensity may be separated into two independent factors representing the normalized extent of signal fluctuation coherence (i.e., correlation coefficient) and the magnitude of spectral intensity changes (i.e., variance). Such separation offers a convenient way to artificially enhance the discriminating power of 2D correlation spectra.

Enhancing gas-phase reaction in a plasma using high intensity and high power ultrasonic acoustic waves

DEFF Research Database (Denmark)

2010-01-01

is absorbed into said plasma (104), and where a sound pressure level of said generated ultrasonic high intensity and high power acoustic waves (102) is at least substantially 140 dB and where an acoustic power of said generated ultrasonic high intensity and high power acoustic waves (102); is at least...... substantially 100 W. In this way, a high sound intensity and power are obtained that efficiently enhances a gas-phase reaction in the plasma, which enhances the plasma process, e.g. enabling more efficient ozone or hydrogen generation using plasma in relation to reaction speed and/or obtained concentration......This invention relates to enhancing a gas-phase reaction in a plasma comprising: creating plasma (104) by at least one plasma source (106), and wherein that the method further comprises: generating ultrasonic high intensity and high power acoustic waves (102) having a predetermined amount...

INEL D&D long-range plan

Energy Technology Data Exchange (ETDEWEB)

Buckland, R.J.; Kenoyer, D.J.; LaBuy, S.A.

1995-09-01

This Long-Range Plan presents the Decontamination and Dismantlement (D&D) Program planning status for facilities at the Idaho National Engineering Laboratory (INEL). The plan provides a general description of the D&D Program objectives, management criteria, and policy; discusses current activities; and documents the INEL D&D Program cost and schedule estimate projections for the next 15 years. Appendices are included that provide INEL D&D project historical information, a comprehensive descriptive summary of each current D&D surplus facility, and a summary database of all INEL contaminated facilities awaiting or undergoing the facility transition process.

BRDF-dependent accuracy of array-projection-based 3D sensors.

Science.gov (United States)

Heist, Stefan; Kühmstedt, Peter; Tünnermann, Andreas; Notni, Gunther

2017-03-10

In order to perform high-speed three-dimensional (3D) shape measurements with structured light systems, high-speed projectors are required. One possibility is an array projector, which allows pattern projection at several tens of kilohertz by switching on and off the LEDs of various slide projectors. The different projection centers require a separate analysis, as the intensity received by the cameras depends on the projection direction and the object's bidirectional reflectance distribution function (BRDF). In this contribution, we investigate the BRDF-dependent errors of array-projection-based 3D sensors and propose an error compensation process.

High-Z material erosion and its control in DIII-D carbon divertor

Directory of Open Access Journals (Sweden)

R. Ding

2017-08-01

Full Text Available As High-Z materials will likely be used as plasma-facing components (PFCs in future fusion devices, the erosion of high-Z materials is a key issue for high-power, long pulse operation. High-Z material erosion and redeposition have been studied using tungsten and molybdenum coated samples exposed in well-diagnosed DIII-D divertor plasma discharges. By coupling dedicated experiments and modelling using the 3D Monte Carlo code ERO, the roles of sheath potential and background carbon impurities in determining high-Z material erosion are identified. Different methods suggested by modelling have been investigated to control high-Z material erosion in DIII-D experiments. The erosion of Mo and W is found to be strongly suppressed by local injection of methane and deuterium gases. The 13C deposition resulting from local 13CH4 injection also provides information on radial transport due to E ×B drifts and cross field diffusion. Finally, D2 gas puffing is found to cause local plasma perturbation, suppressing W erosion because of the lower effective sputtering yield of W at lower plasma temperature and for higher carbon concentration in the mixed surface layer.

Vitamin D: An overview of vitamin D status and intake in Europe.

Science.gov (United States)

Spiro, A; Buttriss, J L

2014-12-01

In recent years, there have been reports suggesting a high prevalence of low vitamin D intakes and vitamin D deficiency or inadequate vitamin D status in Europe. Coupled with growing concern about the health risks associated with low vitamin D status, this has resulted in increased interest in the topic of vitamin D from healthcare professionals, the media and the public. Adequate vitamin D status has a key role in skeletal health. Prevention of the well-described vitamin D deficiency disorders of rickets and osteomalacia are clearly important, but there may also be an implication of low vitamin D status in bone loss, muscle weakness and falls and fragility fractures in older people, and these are highly significant public health issues in terms of morbidity, quality of life and costs to health services in Europe. Although there is no agreement on optimal plasma levels of vitamin D, it is apparent that blood 25-hydroxyvitamin D [25(OH)D] levels are often below recommended ranges for the general population and are particularly low in some subgroups of the population, such as those in institutions or who are housebound and non-Western immigrants. Reported estimates of vitamin D status within different European countries show large variation. However, comparison of studies across Europe is limited by their use of different methodologies. The prevalence of vitamin D deficiency [often defined as plasma 25(OH)D definition of an adequate or optimal vitamin D status is key in determining recommendations for a vitamin D intake that will enable satisfactory status to be maintained all year round, including the winter months. In most European countries, there seems to be a shortfall in achieving current vitamin D recommendations. An exception is Finland, where dietary survey data indicate that recent national policies that include fortification and supplementation, coupled with a high habitual intake of oil-rich fish, have resulted in an increase in vitamin D intakes, but

Dosimetric comparison between intensity-modulated with coplanar field and 3D conformal radiotherapy with noncoplanar field for postocular invasion tumor.

Science.gov (United States)

Wenyong, Tu; Lu, Liu; Jun, Zeng; Weidong, Yin; Yun, Li

2010-01-01

This study presents a dosimetric optimization effort aiming to compare noncoplanar field (NCF) on 3 dimensions conformal radiotherapy (3D-CRT) and coplanar field (CF) on intensity-modulated radiotherapy (IMRT) planning for postocular invasion tumor. We performed a planning study on the computed tomography data of 8 consecutive patients with localized postocular invasion tumor. Four fields NCF 3D-CRT in the transverse plane with gantry angles of 0-10 degrees , 30-45 degrees , 240-270 degrees , and 310-335 degrees degrees were isocentered at the center of gravity of the target volume. The geometry of the beams was determined by beam's eye view. The same constraints were prepared with between CF IMRT optimization and NCF 3D-CRT treatment. The maximum point doses (D max) for the different optic pathway structures (OPS) with NCF 3D-CRT treatment should differ in no more than 3% from those with the NCF IMRT plan. Dose-volume histograms (DVHs) were obtained for all targets and organ at risk (OAR) with both treatment techniques. Plans with NCF 3D-CRT and CF IMRT constraints on target dose in homogeneity were computed, as well as the conformity index (CI) and homogeneity index (HI) in the target volume. The PTV coverage was optimal with both NCF 3D-CRT and CF IMRT plans in the 8 tumor sites. No difference was noted between the two techniques for the average D(max) and D(min) dose. NCF 3D-CRT and CF IMRT will yield similar results on CI. However, HI was a significant difference between NCF 3D-CRT and CF IMRT plan (p 3D-CRT versus CF IMRT set-up is very slight. NCF3D-CRT is one of the treatment options for postocular invasion tumor. However, constraints for OARs are needed. 2010 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.

Dosimetric Comparison Between Intensity-Modulated with Coplanar Field and 3D Conformal Radiotherapy with Noncoplanar Field for Postocular Invasion Tumor

International Nuclear Information System (INIS)

Tu Wenyong; Liu Lu; Zeng Jun; Yin Weidong; Li Yun

2010-01-01

This study presents a dosimetric optimization effort aiming to compare noncoplanar field (NCF) on 3 dimensions conformal radiotherapy (3D-CRT) and coplanar field (CF) on intensity-modulated radiotherapy (IMRT) planning for postocular invasion tumor. We performed a planning study on the computed tomography data of 8 consecutive patients with localized postocular invasion tumor. Four fields NCF 3D-CRT in the transverse plane with gantry angles of 0-10 deg., 30-45 deg., 240-270 deg., and 310-335 deg. degrees were isocentered at the center of gravity of the target volume. The geometry of the beams was determined by beam's eye view. The same constraints were prepared with between CF IMRT optimization and NCF 3D-CRT treatment. The maximum point doses (D max) for the different optic pathway structures (OPS) with NCF 3D-CRT treatment should differ in no more than 3% from those with the NCF IMRT plan. Dose-volume histograms (DVHs) were obtained for all targets and organ at risk (OAR) with both treatment techniques. Plans with NCF 3D-CRT and CF IMRT constraints on target dose in homogeneity were computed, as well as the conformity index (CI) and homogeneity index (HI) in the target volume. The PTV coverage was optimal with both NCF 3D-CRT and CF IMRT plans in the 8 tumor sites. No difference was noted between the two techniques for the average D max and D min dose. NCF 3D-CRT and CF IMRT will yield similar results on CI. However, HI was a significant difference between NCF 3D-CRT and CF IMRT plan (p < 0.001). Physical endpoints for target showed the mean target dose to be low in the CF IMRT plan, caused by a large target dose in homogeneity (p < 0.001). The impact of NCF 3D-CRT versus CF IMRT set-up is very slight. NCF3D-CRT is one of the treatment options for postocular invasion tumor. However, constraints for OARs are needed.

Intense pulsed sources of ions and electrons produced by lasers; Sources pulsees intenses d'ions et d'electrons produites par laser

Energy Technology Data Exchange (ETDEWEB)

Bourrabier, G [Centre de Recherche de la C.S.F., Corbeville (France); Consoli, T; Slama, L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1966-11-01

We describe a device for the acceleration of the plasma burst produced by focusing a laser beam into a metal target. We extract the electrons and the ions from the plasma. The maximum current is around 2000 amperes during few microseconds. The study of the effect of the kind of the target on the characteristics of the current shows the great importance of the initial conditions that is the ionisation potential of the target and the energy laser. (authors) [French] On decrit un dispositif destine a accelerer la bouffee de plasma produite par focalisation d'un faisceau laser sur une cible solide. On extrait du plasma les electrons et les ions. Le courant maximum atteint pres de 2000 amperes pendant quelques microsecondes. L'etude de l'effet de la nature de la cible sur les caracteristiques du courant collecte, met en evidence l'importance des conditions initiales (potentiel d'ionisation de la cible, energie du laser). (auteurs)

Non-equilibrium Modeling of the Fe XVII 3C/3D Line Ratio in an Intense X-Ray Free-Electron Laser Excited Plasma

Science.gov (United States)

Loch, S. D.; Ballance, C. P.; Li, Y.; Fogle, M.; Fontes, C. J.

2015-03-01

Recent measurements using an X-ray Free Electron Laser (XFEL) and an Electron Beam Ion Trap at the Linac Coherent Light Source facility highlighted large discrepancies between the observed and theoretical values for the Fe xvii 3C/3D line intensity ratio. This result raised the question of whether the theoretical oscillator strengths may be significantly in error, due to insufficiencies in the atomic structure calculations. We present time-dependent spectral modeling of this experiment and show that non-equilibrium effects can dramatically reduce the predicted 3C/3D line intensity ratio, compared with that obtained by simply taking the ratio of oscillator strengths. Once these non-equilibrium effects are accounted for, the measured line intensity ratio can be used to determine a revised value for the 3C/3D oscillator strength ratio, giving a range from 3.0 to 3.5. We also provide a framework to narrow this range further, if more precise information about the pulse parameters can be determined. We discuss the implications of the new results for the use of Fe xvii spectral features as astrophysical diagnostics and investigate the importance of time-dependent effects in interpreting XFEL-excited plasmas.

Class D audio amplifiers for high voltage capacitive transducers

DEFF Research Database (Denmark)

Nielsen, Dennis

of high volume, weight, and cost. High efficient class D amplifiers are now widely available offering power densities, that their linear counterparts can not match. Unlike the technology of audio amplifiers, the loudspeaker is still based on the traditional electrodynamic transducer invented by C.W. Rice......Audio reproduction systems contains two key components, the amplifier and the loudspeaker. In the last 20 – 30 years the technology of audio amplifiers have performed a fundamental shift of paradigm. Class D audio amplifiers have replaced the linear amplifiers, suffering from the well-known issues...... with the low level of acoustical output power and complex amplifier requirements, have limited the commercial success of the technology. Horn or compression drivers are typically favoured, when high acoustic output power is required, this is however at the expense of significant distortion combined...

3D CISS, 3D MP-PAGE and 2D TSE for MRI prior to Cochlear implantation

International Nuclear Information System (INIS)

Seitz, J.; Held, P.; Voelk, M.; Lenhart, M.; Strotzer, M.; Waldeck, A.

2000-01-01

Purpose: The aim of this study was to determine the presurgical predictive value of high resolution MRI in patients scheduled for chochlear implantation. Method and material: The presurgical MRI (3D CISS, 3D MP-RAGE with and without i.v. contrast medium, 2D TSE) findings of 54 patients and the intraoperative situation reported by the surgeon were compared retrospectively. The surgical and functional success of the cochlear implantation was evaluated. Results: We found a high degree of correlation between MRI and intraoperative findings concerning the patency of the whole cochlea and anomalies as well as in the diagnosis of pathology of the cochlear, vestibular and facial nerves and in anomalies of the internal auditory canal. However, in four out of 54 patients there was a false negative prediction regarding the patency of the cochlea. The sensitivity was 50% (4/8), the specificity 100% (46/46). Concerning the surgical success the accuracy was 100%. In all patients MRI gave sufficient anatomical information to the surgeon concerning the jugular bulb and the facial nerve. Conclusion: A high-resolution MRI protocol consisting of coronal 2D T2w TSE, 3D T2*w transverse CISS; plain and contrast enhanced sagittal T1w 3D MP-RAGE is recommended for the evaluation of candidates scheduled for cochlear implantation. (orig.) [de

High-Throughput Cancer Cell Sphere Formation for 3D Cell Culture.

Science.gov (United States)

Chen, Yu-Chih; Yoon, Euisik

2017-01-01

Three-dimensional (3D) cell culture is critical in studying cancer pathology and drug response. Though 3D cancer sphere culture can be performed in low-adherent dishes or well plates, the unregulated cell aggregation may skew the results. On contrary, microfluidic 3D culture can allow precise control of cell microenvironments, and provide higher throughput by orders of magnitude. In this chapter, we will look into engineering innovations in a microfluidic platform for high-throughput cancer cell sphere formation and review the implementation methods in detail.

3D Tendon Strain Estimation Using High-frequency Volumetric Ultrasound Images: A Feasibility Study.

Science.gov (United States)

Carvalho, Catarina; Slagmolen, Pieter; Bogaerts, Stijn; Scheys, Lennart; D'hooge, Jan; Peers, Koen; Maes, Frederik; Suetens, Paul

2018-03-01

Estimation of strain in tendons for tendinopathy assessment is a hot topic within the sports medicine community. It is believed that, if accurately estimated, existing treatment and rehabilitation protocols can be improved and presymptomatic abnormalities can be detected earlier. State-of-the-art studies present inaccurate and highly variable strain estimates, leaving this problem without solution. Out-of-plane motion, present when acquiring two-dimensional (2D) ultrasound (US) images, is a known problem and may be responsible for such errors. This work investigates the benefit of high-frequency, three-dimensional (3D) US imaging to reduce errors in tendon strain estimation. Volumetric US images were acquired in silico, in vitro, and ex vivo using an innovative acquisition approach that combines the acquisition of 2D high-frequency US images with a mechanical guided system. An affine image registration method was used to estimate global strain. 3D strain estimates were then compared with ground-truth values and with 2D strain estimates. The obtained results for in silico data showed a mean absolute error (MAE) of 0.07%, 0.05%, and 0.27% for 3D estimates along axial, lateral direction, and elevation direction and a respective MAE of 0.21% and 0.29% for 2D strain estimates. Although 3D could outperform 2D, this does not occur in in vitro and ex vivo settings, likely due to 3D acquisition artifacts. Comparison against the state-of-the-art methods showed competitive results. The proposed work shows that 3D strain estimates are more accurate than 2D estimates but acquisition of appropriate 3D US images remains a challenge.

Power Control for D2D Underlay Cellular Networks With Channel Uncertainty

KAUST Repository

Memmi, Amen

2016-12-26

Device-to-device (D2D) communications underlying the cellular infrastructure are a technology that have been proposed recently as a promising solution to enhance cellular network capabilities. It improves spectrum utilization, overall throughput, and energy efficiency while enabling new peer-to-peer and location-based applications and services. However, interference is the major challenge, since the same resources are shared by both systems. Therefore, interference management techniques are required to keep the interference under control. In this paper, in order to mitigate interference, we consider centralized and distributed power control algorithms in a one-cell random network model. Existing results on D2D underlay networks assume perfect channel state information (CSI). This assumption is usually unrealistic in practice due to the dynamic nature of wireless channels. Thus, it is of great interest to study and evaluate achievable performances under channel uncertainty. Differently from previous works, we are assuming that the CSI may be imperfect and include estimation errors. In the centralized approach, we derive the optimal powers that maximize the coverage probability and the rate of the cellular user while scheduling as many D2D links as possible. These powers are computed at the base station (BS) and then delivered to the users, and hence the name “centralized”. For the distributed method, the ON–OFF power control and the truncated channel inversion are proposed. Expressions of coverage probabilities are established in the function of D2D links intensity, pathloss exponent, and estimation error variance. Results show the important influence of CSI error on achievable performances and thus how crucial it is to consider it while designing networks and evaluating performances.

4D Near Real-Time Environmental Monitoring Using Highly Temporal LiDAR

Science.gov (United States)

Höfle, Bernhard; Canli, Ekrem; Schmitz, Evelyn; Crommelinck, Sophie; Hoffmeister, Dirk; Glade, Thomas

2016-04-01

The last decade has witnessed extensive applications of 3D environmental monitoring with the LiDAR technology, also referred to as laser scanning. Although several automatic methods were developed to extract environmental parameters from LiDAR point clouds, only little research has focused on highly multitemporal near real-time LiDAR (4D-LiDAR) for environmental monitoring. Large potential of applying 4D-LiDAR is given for landscape objects with high and varying rates of change (e.g. plant growth) and also for phenomena with sudden unpredictable changes (e.g. geomorphological processes). In this presentation we will report on the most recent findings of the research projects 4DEMON (http://uni-heidelberg.de/4demon) and NoeSLIDE (https://geomorph.univie.ac.at/forschung/projekte/aktuell/noeslide/). The method development in both projects is based on two real-world use cases: i) Surface parameter derivation of agricultural crops (e.g. crop height) and ii) change detection of landslides. Both projects exploit the "full history" contained in the LiDAR point cloud time series. One crucial initial step of 4D-LiDAR analysis is the co-registration over time, 3D-georeferencing and time-dependent quality assessment of the LiDAR point cloud time series. Due to the high amount of datasets (e.g. one full LiDAR scan per day), the procedure needs to be performed fully automatically. Furthermore, the online near real-time 4D monitoring system requires to set triggers that can detect removal or moving of tie reflectors (used for co-registration) or the scanner itself. This guarantees long-term data acquisition with high quality. We will present results from a georeferencing experiment for 4D-LiDAR monitoring, which performs benchmarking of co-registration, 3D-georeferencing and also fully automatic detection of events (e.g. removal/moving of reflectors or scanner). Secondly, we will show our empirical findings of an ongoing permanent LiDAR observation of a landslide (Gresten

Parameterizations of Chromospheric Condensations in dG and dMe Model Flare Atmospheres

Science.gov (United States)

Kowalski, Adam F.; Allred, Joel C.

2018-01-01

The origin of the near-ultraviolet and optical continuum radiation in flares is critical for understanding particle acceleration and impulsive heating in stellar atmospheres. Radiative-hydrodynamic (RHD) simulations in 1D have shown that high energy deposition rates from electron beams produce two flaring layers at T ∼ 104 K that develop in the chromosphere: a cooling condensation (downflowing compression) and heated non-moving (stationary) flare layers just below the condensation. These atmospheres reproduce several observed phenomena in flare spectra, such as the red-wing asymmetry of the emission lines in solar flares and a small Balmer jump ratio in M dwarf flares. The high beam flux simulations are computationally expensive in 1D, and the (human) timescales for completing NLTE models with adaptive grids in 3D will likely be unwieldy for some time to come. We have developed a prescription for predicting the approximate evolved states, continuum optical depth, and emergent continuum flux spectra of RHD model flare atmospheres. These approximate prescriptions are based on an important atmospheric parameter: the column mass ({m}{ref}) at which hydrogen becomes nearly completely ionized at the depths that are approximately in steady state with the electron beam heating. Using this new modeling approach, we find that high energy flux density (>F11) electron beams are needed to reproduce the brightest observed continuum intensity in IRIS data of the 2014 March 29 X1 solar flare, and that variation in {m}{ref} from 0.001 to 0.02 g cm‑2 reproduces most of the observed range of the optical continuum flux ratios at the peak of M dwarf flares.

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Energy Technology Data Exchange (ETDEWEB)

Chien, Ellen Y.T.; Liu, Wei; Zhao, Qiang; Katritch, Vsevolod; Han, Gye Won; Hanson, Michael A.; Shi, Lei; Newman, Amy Hauck; Javitch, Jonathan A.; Cherezov, Vadim; Stevens, Raymond C. (Cornell); (Scripps); (NIDA); (Columbia); (UCSD); (Receptos)

2010-11-30

Dopamine modulates movement, cognition, and emotion through activation of dopamine G protein-coupled receptors in the brain. The crystal structure of the human dopamine D3 receptor (D3R) in complex with the small molecule D2R/D3R-specific antagonist eticlopride reveals important features of the ligand binding pocket and extracellular loops. On the intracellular side of the receptor, a locked conformation of the ionic lock and two distinctly different conformations of intracellular loop 2 are observed. Docking of R-22, a D3R-selective antagonist, reveals an extracellular extension of the eticlopride binding site that comprises a second binding pocket for the aryl amide of R-22, which differs between the highly homologous D2R and D3R. This difference provides direction to the design of D3R-selective agents for treating drug abuse and other neuropsychiatric indications.

The effect of vitamin D on primary dysmenorrhea with vitamin D deficiency: a randomized double-blind controlled clinical trial.

Science.gov (United States)

Moini, Ashraf; Ebrahimi, Tabandeh; Shirzad, Nooshin; Hosseini, Reihaneh; Radfar, Mania; Bandarian, Fatemeh; Jafari-Adli, Shahrzad; Qorbani, Mostafa; Hemmatabadi, Mahboobeh

2016-06-01

Dysmenorrhea is common among women of reproductive age. This study aim was to investigate the effect of vitamin D (vit D) supplementation in treatment of primary dysmenorrhea with vit D deficiency. A randomized double-blind placebo-controlled clinical trial was conducted on 60 women with primary dysmenorrhea and vit D deficiency referred to our clinic at Arash Women's Hospital from September 2013 to December 2014. Eligible women were randomly assigned into treatment and control groups (30 in each group). Individuals in the treatment group received 50 000 IU oral vit D and the control group received placebo weekly for eight weeks. After two months of treatment, there was a significant difference in serum vit D concentration between the two groups (p dysmenorrhea and vit D deficiency could improve pain intensity.

Transitional cell carcinoma express vitamin D receptors

DEFF Research Database (Denmark)

Hermann, G G; Andersen, C B

1997-01-01

Recently, vitamin D analogues have shown antineoplastic effect in several diseases. Vitamin D analogues exert its effect by interacting with the vitamin D receptor (VDR). Studies of VDR in transitional cell carcinoma (TCC) have not been reported. The purpose of the present study was therefore.......05). Similarly, also tumor grade appeared to be related to the number of cells expressing the receptor. Normal urothlium also expressed VDR but only with low intensity. Our study shows that TCC cells possess the VDR receptor which may make them capable to respond to stimulation with vitamin D, but functional...... studies of vitamin D's effect on TCC cells in vitro are necessary before the efficacy of treatment with vitamin D analogues in TCC can be evaluated in patients....

A High Precision $3.50 Open Source 3D Printed Rain Gauge Calibrator

Science.gov (United States)

Lopez Alcala, J. M.; Udell, C.; Selker, J. S.

2017-12-01

Currently available rain gauge calibrators tend to be designed for specific rain gauges, are expensive, employ low-precision water reservoirs, and do not offer the flexibility needed to test the ever more popular small-aperture rain gauges. The objective of this project was to develop and validate a freely downloadable, open-source, 3D printed rain gauge calibrator that can be adjusted for a wide range of gauges. The proposed calibrator provides for applying low, medium, and high intensity flow, and allows the user to modify the design to conform to unique system specifications based on parametric design, which may be modified and printed using CAD software. To overcome the fact that different 3D printers yield different print qualities, we devised a simple post-printing step that controlled critical dimensions to assure robust performance. Specifically, the three orifices of the calibrator are drilled to reach the three target flow rates. Laboratory tests showed that flow rates were consistent between prints, and between trials of each part, while the total applied water was precisely controlled by the use of a volumetric flask as the reservoir.

3D modeling of high-Tc superconductors by finite element software

International Nuclear Information System (INIS)

Zhang Min; Coombs, T A

2012-01-01

A three-dimensional (3D) numerical model is proposed to solve the electromagnetic problems involving transport current and background field of a high-T c superconducting (HTS) system. The model is characterized by the E–J power law and H-formulation, and is successfully implemented using finite element software. We first discuss the model in detail, including the mesh methods, boundary conditions and computing time. To validate the 3D model, we calculate the ac loss and trapped field solution for a bulk material and compare the results with the previously verified 2D solutions and an analytical solution. We then apply our model to test some typical problems such as superconducting bulk array and twisted conductors, which cannot be tackled by the 2D models. The new 3D model could be a powerful tool for researchers and engineers to investigate problems with a greater level of complicity.

Characterizing 3D sensors using the 3D modulation transfer function

Science.gov (United States)

Kellner, Timo; Breitbarth, Andreas; Zhang, Chen; Notni, Gunther

2018-03-01

The fields of optical 3D measurement system applications are continuously expanding and becoming more and more diverse. To evaluate appropriate systems for various measurement tasks, comparable parameters are necessary, whereas the 3D modulation transfer function (3D-MTF) has been established as a further criterion. Its aim is the determination of the system response between the measurement of a straight, sharp-edged cube and its opposite ideal calculated one. Within the scope of this work simulations and practical investigations regarding the 3D-MTF’s influences and its main issues are specifically investigated. Therefore, different determined edge radii representing the high-frequency spectra lead to various decreasing 3D-MTF characteristics. Furthermore, rising sampling frequencies improve its maximum transfer value to a saturation point in dependence of the radius. To approve these results of previous simulations, three fringe projection scanners were selected to determine the diversity. As the best 3D-MTF characteristic, a saturated transfer value of H_3D( f_N, 3D) = 0.79 has been identified at a sufficient sampling frequency, which is reached at four times the Nyquist limit. This high 3D resolution can mainly be achieved due to an improved camera projector interaction. Additionally, too small sampling ratios lead to uncertainties in the edge function determination, while higher ratios do not show major improvements. In conclusion, the 3D-MTF algorithm has thus been practically verified and its repeatability as well as its robustness have been confirmed.

24,25,28-Trihydroxyvitamin D2 and 24,25,26-trihydroxyvitamin D2: Novel metabolites of vitamin D2

International Nuclear Information System (INIS)

Reddy, G.S.; Tserng, K.

1990-01-01

Understanding of the inactivation pathways of 25-hydroxyvitamin D 2 and 24-hydroxyvitamin D 2 , the two physiologically significant monohydroxylated metabolites of vitamin D 2 , is of importance, especially during hypervitaminosis D 2 . At present, little information is available regarding the inactivation pathway of 25-hydroxyvitamin D 2 except its further metabolism into 24,25-dihydroxyvitamin D 2 . In our present study, the authors investigated the metabolic fate of 25-hydroxyvitamin D 2 in the isolated perfused rat kidney and demonstrated its conversion not only into 24,25-dihydroxyvitamin D 2 but also into two other new metabolites, namely, 24,25,28-trihydroxyvitamin D 2 and 24,25,26-trihydroxyvitamin D 2 . The structure identification of the new metabolites was established by the techniques of ultraviolet absorption spectrophotometry and mass spectrometry and by the characteristic nature of each new metabolite's susceptibility to sodium metaperiodate oxidation. In order to demonstrate the physiological significance of the two new trihydroxy metabolites of vitamin D 2 , induced hypervitaminosis D 2 in a rat using [3α- 3 H]vitamin D 2 and analyzed its plasma for the various [3α- 3 H]vitamin D 2 metabolites on two different high-pressure liquid chromatography systems. The results indicate that both 24,25,26-trihydroxyvitamin D 2 and 24,25,26-trihydroxyvitamin D 2 circulate in the vitamin D 2 intoxicated rat in significant amounts along with other previously identified monohydroxy and dihydroxy metabolites of vitamin D 2 , namely, 24-hydroxyvitamin D 2 , 25-hydroxyvitamin D 2 , and 24,25-dihydroxyvitamin D 2

Nonclassical Vitamin D Actions

Directory of Open Access Journals (Sweden)

Armin Zittermann

2010-03-01

Full Text Available It is becoming increasingly clear that vitamin D has a broad range of actions in the human body. Besides its well-known effects on calcium/phosphate homeostasis, vitamin D influences muscle function, cardiovascular homeostasis, nervous function, and the immune response. Vitamin D deficiency/insufficiency has been associated with muscle weakness and a high incidence of various chronic diseases such as cardiovascular disease, cancer, multiple sclerosis, and type 1 and 2 diabetes. Most importantly, low vitamin D status has been found to be an independent predictor of all-cause mortality. Several recent randomized controlled trials support the assumption that vitamin D can improve muscle strength, glucose homeostasis, and cardiovascular risk markers. In addition, vitamin D may reduce cancer incidence and elevated blood pressure. Since the prevalence of vitamin D deficiency/insufficiency is high throughout the world, there is a need to improve vitamin D status in the general adult population. However, the currently recommended daily vitamin D intake of 5–15 µg is too low to achieve an adequate vitamin D status in individuals with only modest skin synthesis. Thus, there is a need to recommend a vitamin D intake that is effective for achieving adequate circulating 25-hydroxyvitamin D concentrations (>75 nmol/L.

3D shaping of electron beams using amplitude masks

Energy Technology Data Exchange (ETDEWEB)

Shiloh, Roy, E-mail: royshilo@post.tau.ac.il; Arie, Ady

2017-06-15

Highlights: • Electron beams are shaped in 3D with examples of curves and lattices. • Computer generated holograms are manifested as binary amplitude masks. • Applications in electron-optical particle trapping, manipulation, and synthesis. • Electron beam lithography fabrication scheme explained in detail. • Measurement paradigms of 3D shaped beams are discussed. - Abstract: Shaping the electron wavefunction in three dimensions may prove to be an indispensable tool for research involving atomic-sized particle trapping, manipulation, and synthesis. We utilize computer-generated holograms to sculpt electron wavefunctions in a standard transmission electron microscope in 3D, and demonstrate the formation of electron beams exhibiting high intensity along specific trajectories as well as shaping the beam into a 3D lattice of hot-spots. The concepts presented here are similar to those used in light optics for trapping and tweezing of particles, but at atomic scale resolutions.

Advances in research on 2D and 3D graphene-based supercapacitors

Science.gov (United States)

Mensing, Johannes Ph.; Poochai, Chatwarin; Kerdpocha, Sadanan; Sriprachuabwong, Chakrit; Wisitsoraat, Anurat; Tuantranont, Adisorn

2017-09-01

Graphene-based materials in two-dimensional (2D) and three-dimensional (3D) configurations are promising as electrode materials for supercapacitors due to their large surface area, excellent electrical conductivity, high electrochemical activity and high stability. In this article recent advances in research on 2D and 3D graphene-based materials for supercapacitor electrodes are reviewed extensively in aspects of fabrication methods and electrochemical performances. From the survey, the performance of 2D and 3D graphene-based materials could be significantly enhanced by employing nanostructures of metal oxides, metals and polymers as well as doping graphene with hetero atoms such as nitrogen and boron. In addition, the charge storage performances were found to depend greatly on materials, preparation method and structural configuration. With similar material components, 3D graphene-based networks tended to exhibit superior supercapacitive performances. Therefore, future research should be focusing on further development of 3D graphene-based materials for supercapacitor applications. Invited talk at 5th Thailand International Nanotechnology Conference (Nano Thailand-2016), 27-29 November 2016, Nakhon Ratchasima, Thailand.

Preparation and luminescence properties of Eu2+-doped CaSi2O2-dN2+2/3d phosphors

International Nuclear Information System (INIS)

Gu Yunxin; Zhang Qinghong; Wang Hongzhi; Li Yaogang

2009-01-01

Eu 2+ -doped CaSi 2 O 2-d N 2+2/3d phosphors for white LED lamps were prepared by solid-state reaction, and the effects of heat-treatment conditions and the overall composition of host lattice on the optical properties have been discussed. Eu 2+ -doped CaSi 2 O 2-d N 2+2/3d displayed a single broad emission band peak at 540 nm, which could be assigned to the allowed transition of Eu 2+ from the lowest crystal field component of 4f 6 5d to 4f 7 ground-state level. The excitation band of samples, extending from UV to blue, is extremely wide, so the phosphors are suitable for white LED lamps in combination with a UV or blue LED dies. The highest PL intensity is found for the sample sintered at 1400 0 C. Moreover, the emission intensity decreases when N partially replaces O. A red shift of emission wavelength did not occur with increasing of the N content.

Development of apparatus for high-intensity beam lines at the KEK-PS new experimental hall

International Nuclear Information System (INIS)

Yamanoi, Yutaka; Tanaka, Kazuhiro; Minakawa, Michifumi

1992-01-01

The new counter experimental hall was constructed at the KEK 12 GeV Proton Synchrotron (the KEK-PS) in order to handle high-intensity primary proton beams of up to 1 x 10 13 pps (protons per second), which is one order of magnitude greater than the present beam intensity of the KEK-PS, 1 x 10 12 pps. New technologies for handling high-intensity beams have, then, been developed and employed in the new hall construction. A part of our R/D work on handling high intensity beam is briefly reported. (author)

A BES proposal, searching for D0-bar D0 mixing

International Nuclear Information System (INIS)

Rongsheng, X.

1990-01-01

The measurement of D 0 - D -0 mixing is of great interest for BES. Since the Standard Model predicts the approximate value for this process ( -3 ). But, the experimental showed only 10 -2 level. Clearly, more data are needed to reach a real conclusion. BEPC is going to run at Ψ double-prime (3770) energy region next year with the high luminosity, Ψ double-prime (3770) is just 40 MeV above D bar D threshold decaying about 100% of the time into D bar D (57% D 0 D -0 , 43% D + D - ) which is very good for searching D 0 - D -0 mixing events. This paper reports that due to D decays into hadronic or leptonic final states in sort time, the main experimental requirements are good mass resolution to reconstruct masses from decay products. Good particle identification to minimize combinational background. Good vertex detection in cases where flight path are reconstructed. Good detection efficiency to avoid losing events in cases limited by statistics. For D decaying, it yields, on average, the momentum of final states: π = 250 MeV/c, Kaon = 600 MeV/c, Photon = 125 MeV/c. BES detector located at BEPC has been optimized to detect particle

2D-Driven 3D Object Detection in RGB-D Images

KAUST Repository

Lahoud, Jean

2017-12-25

In this paper, we present a technique that places 3D bounding boxes around objects in an RGB-D scene. Our approach makes best use of the 2D information to quickly reduce the search space in 3D, benefiting from state-of-the-art 2D object detection techniques. We then use the 3D information to orient, place, and score bounding boxes around objects. We independently estimate the orientation for every object, using previous techniques that utilize normal information. Object locations and sizes in 3D are learned using a multilayer perceptron (MLP). In the final step, we refine our detections based on object class relations within a scene. When compared to state-of-the-art detection methods that operate almost entirely in the sparse 3D domain, extensive experiments on the well-known SUN RGB-D dataset [29] show that our proposed method is much faster (4.1s per image) in detecting 3D objects in RGB-D images and performs better (3 mAP higher) than the state-of-the-art method that is 4.7 times slower and comparably to the method that is two orders of magnitude slower. This work hints at the idea that 2D-driven object detection in 3D should be further explored, especially in cases where the 3D input is sparse.

A 3D heat conduction model for block-type high temperature reactors and its implementation into the code DYN3D

International Nuclear Information System (INIS)

Baier, Silvio; Kliem, Soeren; Rohde, Ulrich

2011-01-01

The gas-cooled high temperature reactor is a concept to produce energy at high temperatures with a high level of inherent safety. It gets special attraction due to e.g. high thermal efficiency and the possibility of hydrogen production. In addition to the PBMR (Pebble Bed Modular Reactor) the (V)HTR (Very high temperature reactor) concept has been established. The basic design of a prismatic HTR consists of the following elements. The fuel is coated with four layers of isotropic materials. These so-called TRISO particles are dispersed into compacts which are placed in a graphite block matrix. The graphite matrix additionally contains holes for the coolant gas. A one-dimensional model is sufficient to describe (the radial) heat transfer in LWRs. But temperature gradients in a prismatic HTR can occur in axial as well as in radial direction, since regions with different heat source release and with different coolant temperature heat up are coupled through the graphite matrix elements. Furthermore heat transfer into reflector elements is possible. DYN3D is a code system for coupled neutron and thermal hydraulics core calculations developed at the Helmholtzzentrum Dresden-Rossendorf. Concerning neutronics DYN3D consists of a two-group and multi-group diffusion approach based on nodal expansion methods. Furthermore a 1D thermal-hydraulics model for parallel coolant flow channels is included. The DYN3D code was extensively verified and validated via numerous numerical and experimental benchmark problems. That includes the NEA CRP benchmarks for PWR and BWR, the Three-Miles-Island-1 main steam line break and the Peach Bottom Turbine Trip benchmarks, as well as measurements carried out in an original-size VVER-1000 mock-up. An overview of the verification and validation activities can be found. Presently a DYN3D-HTR version is under development. It involves a 3D heat conduction model to deal with higher-(than one)-dimensional effects of heat transfer and heat conduction in

Applications of High Intensity Proton Accelerators

Science.gov (United States)

Raja, Rajendran; Mishra, Shekhar

2010-06-01

Superconducting radiofrequency linac development at Fermilab / S. D. Holmes -- Rare muon decay experiments / Y. Kuno -- Rare kaon decays / D. Bryman -- Muon collider / R. B. Palmer -- Neutrino factories / S. Geer -- ADS and its potential / J.-P. Revol -- ADS history in the USA / R. L. Sheffield and E. J. Pitcher -- Accelerator driven transmutation of waste: high power accelerator for the European ADS demonstrator / J. L. Biarrotte and T. Junquera -- Myrrha, technology development for the realisation of ADS in EU: current status & prospects for realisation / R. Fernandez ... [et al.] -- High intensity proton beam production with cyclotrons / J. Grillenberger and M. Seidel -- FFAG for high intensity proton accelerator / Y. Mori -- Kaon yields for 2 to 8 GeV proton beams / K. K. Gudima, N. V. Mokhov and S. I. Striganov -- Pion yield studies for proton driver beams of 2-8 GeV kinetic energy for stopped muon and low-energy muon decay experiments / S. I. Striganov -- J-Parc accelerator status and future plans / H. Kobayashi -- Simulation and verification of DPA in materials / N. V. Mokhov, I. L. Rakhno and S. I. Striganov -- Performance and operational experience of the CNGS facility / E. Gschwendtner -- Particle physics enabled with super-conducting RF technology - summary of working group 1 / D. Jaffe and R. Tschirhart -- Proton beam requirements for a neutrino factory and muon collider / M. S. Zisman -- Proton bunching options / R. B. Palmer -- CW SRF H linac as a proton driver for muon colliders and neutrino factories / M. Popovic, C. M. Ankenbrandt and R. P. Johnson -- Rapid cycling synchrotron option for Project X / W. Chou -- Linac-based proton driver for a neutrino factory / R. Garoby ... [et al.] -- Pion production for neutrino factories and muon colliders / N. V. Mokhov ... [et al.] -- Proton bunch compression strategies / V. Lebedev -- Accelerator test facility for muon collider and neutrino factory R&D / V. Shiltsev -- The superconducting RF linac for muon

3D-CT of the temporal bone area with high-speed processing

International Nuclear Information System (INIS)

Hattori, Taku

1994-01-01

Three-dimentional (3D)-CT was introduced to represent abnormal findings in the temporal bone area utilizing a SOMATOM DRH CT scanner with accessory 3D reconstruction software and an exclusive high-speed 3D processing system, VOXEL FLINGER. In a patient with eosinophilic granuloma, a defect in the squamous part of the temporal bone was demonstrated suggesting exposure of the dura mater during surgery. In a patient with a normal ear, well-developed mastoid cavity, a part of the handle and the head of the malleus, the incudomalleal joint, the short limb, body and a part of the long limb of the incus and the round window niche were demonstrated. In a case of chronic otitis media, poorly developed mastoid cavity and a possible defect of the tip of the long limb of the incus were demonstrated, in contrast to the patient with the normal ear. 3D-CT yields objective and solid images which are useful for diagnosis, treatment planning and explanation of the pathology to patients and their family. To obtain convincing 3D images, physicians themselves have to choose exact rotation angles. It is not adequate to reconstruct original CT data using a CT computer with accessory 3D software whose processing capability is not good enough for this purpose. The conclusion is as follows: 1) it is necessary and effective to transfer original CT data into the memory of the exclusive high-speed 3D processing system and 2) process the data by the voxel memory method to establish a clinically valuable 3D-CT imaging system. (author)

High-Intensity Events in International Women's Team Handball Matches.

Science.gov (United States)

Luteberget, Live S; Spencer, Matt

2017-01-01

International women's team handball is a physically demanding sport and is intermittent in nature. The aim of the study was to profile high-intensity events (HIEs) in international women's team handball matches with regard to playing positions. Twenty female national-team handball players were equipped with inertial movement units (OptimEye S5, Catapult Sports, Australia) in 9 official international matches. Players were categorized in 4 different playing positions: backs, wings, pivots, and goalkeepers (GKs). PlayerLoad™, accelerations (Acc), changes of direction (CoD), decelerations (Dec), and the sum of the latter 3, HIEs, were extracted from raw-data files using the manufacturer's software. All Acc, Dec, CoD, and HIEs >2.5 m/s were included. Data were log-transformed and differences were standardized for interpretation of magnitudes and reported with effect-size statistics. Mean numbers of events were 0.7 ± 0.4 Acc/min, 2.3 ± 0.9 Dec/min, and 1.0 ± 0.4 CoD/min. Substantial differences between playing positions, ranging from small to very large, were found in the 3 parameters. Backs showed a most likely greater frequency for HIE/min (5.0 ± 1.1 HIE/min) than all other playing positions. Differences between playing positions were also apparent in PlayerLoad/min. HIEs in international women's team handball are position specific, and the overall intensity depends on the positional role within a team. Specific HIE and intensity profiles from match play provide useful information for a better understanding of the overall game demands and for each playing position.

Bioluminescence imaging of chondrocytes in rabbits by intraarticular injection of D-luciferin

Energy Technology Data Exchange (ETDEWEB)

Moon, Sung Min; Min, Jung Joon; Kim, Sung Mi; Bom, Hee Seung [Chonnam National University Medical School, Gwangju (Korea, Republic of); Oh, Suk Jung; Kang, Han Saem; Kim, Kwang Yoon [ECOBIO INC., Gwangju (Korea, Republic of); Kim, Young Ho [College of Natural Science, Chosun University, Gwangju (Korea, Republic of)

2007-02-15

Luciferase is one of the most commonly used reporter enzymes in the field of in vivo optical imaging. D-luciferin, the substrate for firefly luciferase has very high cost that allows this kind of experiment limited to small animals such as mice and rats. In this current study, we validated local injection of D-luciferin in the articular capsule for bioluminescence imaging in rabbits. Chondrocytes were cultured and infected by replication-defective adenoviral vector encoding firefly luciferase (Fluc). Chondrocytes expressing Fluc were injected or implanted in the left knee joint. The rabbits underwent optical imaging studies after local injection of D-luciferin at 1, 5, 7, 9 days after cellular administration. We sought whether optimal imaging signals was could be by a cooled CCD camera after local injection of D-luciferin. Imaging signal was not observed from the left knee joint after intraperitoneal injection of D-luciferin (15 mg/kg), whereas it was observed after intraarticular injection. Photon intensity from the left knee joint of rabbits was compared between cell injected and implanted groups after intraarticular injection of D-luciferin. During the period of imaging studies, photon intensity of the cell implanted group was 5-10 times higher than that of the cell injected group. We successfully imaged chondrocytes expressing Fluc after intraarticular injection of D-luciferin. This technique may be further applied to develop new drugs for knee joint disease.

Site characterization of ORNL D ampersand D facilities

International Nuclear Information System (INIS)

Kelsey, A.P.; Mandry, G.J.; Haghighi, M.H.

1994-01-01

Site characterization for decontamination and decommissioning (D ampersand D) planning purposes was done for two surplus facilities at Oak Ridge National Laboratory (ORNL) in late 1993 and early 1994. This site characterization includes measurements of radiological and chemical contaminants, assessment of general structural conditions, and investigation of unknown conditions within the buildings. It will serve as input to decisions on D ampersand D engineering, D ampersand D task sequences, radiological and contamination control, and waste management. This paper presents the methods used to investigate these facilities and discusses the preliminary results as they apply to D ampersand D planning. Investigation methods include gross alpha, beta, and gamma surveys; directional gamma surveys; gamma spectroscopy; concrete coring; photography; and collection of soil and miscellaneous samples that are analyzed for radiological and chemical contaminants. Data will be analyzed using radiological models to sort sources and estimate exposure rates and waste volumes due to D ampersand D. The former Waste Evaporator Facility (WEF), consisting of two concrete cells and an operating gallery, once contained a liquid radwaste evaporator. Subsequently it was used for an incinerator experiment and as a dressing area for remediation work on an adjacent tank farm. The building has been partially decontaminated. Figure 1 is a photograph of the WEF. The Fission Product Pilot Plant (FPPP) is a small concrete building containing two cells. It was used to extract isotopes of ruthenium, strontium, cesium, cerium, and other elements from liquid waste. This facility is highly contaminated. In 1960 all doors into FPPP were sealed with concrete block and mortar, and concrete block shielding was added to the external walls making them up to five feet thick. Prior to this study, almost nothing was known about the interior of this building

High-Resolution Multibeam Sonar Survey and Interactive 3-D Exploration of the D-Day Wrecks off Normandy

Science.gov (United States)

Mayer, L. A.; Calder, B.; Schmidt, J. S.

2003-12-01

Historically, archaeological investigations use sidescan sonar and marine magnetometers as initial search tools. Targets are then examined through direct observation by divers, video, or photographs. Magnetometers can demonstrate the presence, absence, and relative susceptibility of ferrous objects but provide little indication of the nature of the target. Sidescan sonar can present a clear image of the overall nature of a target and its surrounding environment, but the sidescan image is often distorted and contains little information about the true 3-D shape of the object. Optical techniques allow precise identification of objects but suffer from very limited range, even in the best of situations. Modern high-resolution multibeam sonar offers an opportunity to cover a relatively large area from a safe distance above the target, while resolving the true three-dimensional (3-D) shape of the object with centimeter-level resolution. The combination of 3-D mapping and interactive 3-D visualization techniques provides a powerful new means to explore underwater artifacts. A clear demonstration of the applicability of high-resolution multibeam sonar to wreck and artifact investigations occurred when the Naval Historical Center (NHC), the Center for Coastal and Ocean Mapping (CCOM) at the University of New Hampshire, and Reson Inc., collaborated to explore the state of preservation and impact on the surrounding environment of a series of wrecks located off the coast of Normandy, France, adjacent to the American landing sectors The survey augmented previously collected magnetometer and high-resolution sidescan sonar data using a Reson 8125 high-resolution focused multibeam sonar with 240, 0.5° (at nadir) beams distributed over a 120° swath. The team investigated 21 areas in water depths ranging from about three -to 30 meters (m); some areas contained individual targets such as landing craft, barges, a destroyer, troop carrier, etc., while others contained multiple smaller

Self-powered heat-resistant polymeric 1D nanowires and 3D micro/nanowire assemblies in a pressure-crystallized size-distributed graphene oxide/poly (vinylidene fluoride) composite

Science.gov (United States)

Tian, Pengfei; Lyu, Jun; Huang, Rui; Zhang, Chaoliang

2017-12-01

Piezoelectric one- (1D) and three-dimensional (3D) hybrid micro/nanostructured materials have received intense research interest because of their ability in capturing trace amounts of energy and transforming it into electrical energy. In this work, a size-distributed graphene oxide (GO) was utilized for the concurrent growth of both the 1D nanowires and 3D micro/nanowire architectures of poly (vinylidene fluoride) (PVDF) with piezoelectricity. The in situ formation of the polymeric micro/nanostructures, with crystalline beta phase, was achieved by the high-pressure crystallization of a well dispersed GO/PVDF composite, fabricated by an environmentally friendly physical approach. Particularly, by controlling the crystallization conditions of the binary composite at high pressure, the melting point of the polymeric micro/nanowires, which further constructed the 3D micro/nanoarchitectures, was nearly 30°C higher than that of the original PVDF. The large scale simultaneous formation of the 1D and 3D micro/nanostructures was attributed to a size-dependent catalysis of the GOs in the pressure-treated composite system. The as-fabricated heat-resistant hybrid micro/nanoarchitectures, consisting of GOs and piezoelectric PVDF micro/nanowires, may permit niche applications in self-powered micro/nanodevices for energy scavenging from their working environments.

MR imaging of cranial nerve lesions using six different high-resolution T1- and T2(*)-weighted 3D and 2D sequences

Energy Technology Data Exchange (ETDEWEB)

Seitz, J.; Held, P.; Strotzer, M.; Voelk, M.; Nitz, W.R.; Dorenbeck, U.; Feuerbach, S. [Univ. Hospital of Regensburg (Germany). Dept. of Diagnostic Radiology; Stamato, S. [Univ. of California, San Diego, CA (United States). Dept. of Radiology

2002-07-01

Purpose: To find a suitable high-resolution MR protocol for the visualization of lesions of all 12 cranial nerves. Material and Methods: Thirty-eight pathologically changed cranial nerves (17 patients) were studied with MR imaging at 1.5T using 3D T2*-weighted CISS, T1-weighted 3D MP-RAGE (without and with i.v. contrast medium), T2-weighted 3D TSE, T2-weighted 2D TSE and T1-weighted fat saturation 2D TSE sequences. Visibility of the 38 lesions of the 12 cranial nerves in each sequence was evaluated by consensus of two radiologists using an evaluation scale from 1 (excellently visible) to 4 (not visible). Results: The 3D CISS sequence provided the best resolution of the cranial nerves and their lesions when surrounded by CSF. In nerves which were not surrounded by CSF, the 2D T1-weighted contrast-enhanced fat suppression technique was the best sequence. Conclusions: A combination of 3D CISS, the 2D T1-weighted fat suppressed sequence and a 3D contrast-enhanced MP-RAGE proved to be the most useful sequence to visualize all lesions of the cranial nerves. For the determination of enhancement, an additional 3D MP-RAGE sequence without contrast medium is required. This sequence is also very sensitive for the detection of hemorrhage.

MR imaging of cranial nerve lesions using six different high-resolution T1- and T2(*)-weighted 3D and 2D sequences

International Nuclear Information System (INIS)

Seitz, J.; Held, P.; Strotzer, M.; Voelk, M.; Nitz, W.R.; Dorenbeck, U.; Feuerbach, S.; Stamato, S.

2002-01-01

Purpose: To find a suitable high-resolution MR protocol for the visualization of lesions of all 12 cranial nerves. Material and Methods: Thirty-eight pathologically changed cranial nerves (17 patients) were studied with MR imaging at 1.5T using 3D T2*-weighted CISS, T1-weighted 3D MP-RAGE (without and with i.v. contrast medium), T2-weighted 3D TSE, T2-weighted 2D TSE and T1-weighted fat saturation 2D TSE sequences. Visibility of the 38 lesions of the 12 cranial nerves in each sequence was evaluated by consensus of two radiologists using an evaluation scale from 1 (excellently visible) to 4 (not visible). Results: The 3D CISS sequence provided the best resolution of the cranial nerves and their lesions when surrounded by CSF. In nerves which were not surrounded by CSF, the 2D T1-weighted contrast-enhanced fat suppression technique was the best sequence. Conclusions: A combination of 3D CISS, the 2D T1-weighted fat suppressed sequence and a 3D contrast-enhanced MP-RAGE proved to be the most useful sequence to visualize all lesions of the cranial nerves. For the determination of enhancement, an additional 3D MP-RAGE sequence without contrast medium is required. This sequence is also very sensitive for the detection of hemorrhage

Production of the excited charm mesons D1 and D*2 at HERA

International Nuclear Information System (INIS)

Verbytskyi, Andrii

2013-02-01

The production of the excited charm mesons D 1 , D * 2 and D + s1 in ep collisions has been measured with the ZEUS detector at Hera. The data sample taken by the ZEUS detector in the years 2003-2007, corresponding to an integrated luminosity of 373 pb -1 has been used. The masses of the neutral, charged and strange states, the widths of the neutral states, the helicity parameters of D 0 1 and D + s1 were determined and compared with other measurements and with theoretical expectations. The measured helicity parameters of the D 0 1 and D + s1 allows for some mixing of S- and D-waves in their decays to D *± π -+ and D *± K 0 respectively. The measured value of the D 0 1 helicity parameter is also consistent with a pure D-wave decay. Ratios of branching fractions of the two decay modes of the D *0 2 , D *± 2 and D + s1 states were measured and compared with previous measurements. The fractions of charm quarks hadronising into D 1 , D * 2 and D + s1 were measured and are consistent with those obtained in e + e - annihilations. The Grid computing technology has a high importance for modern High Energy Physics. This technology has been successfully used in Zeus experiment for the MC simulations and data analysis. The dedicated infrastructure has been maintained by the author since 2010. In addition to continuous support, the author has upgraded and improved the performance of the Grid MC simulations and contributed to the Zeus data preservation project.

Recent DIII-D high power heating and current drive experiments

International Nuclear Information System (INIS)

Simonen, T.C.; Jackson, G.L.; Mahdavi, M.A.; Petrie, T.W.; Politzer, P.A.; Taylor, T.S.; Lazarus, E.A.

1994-02-01

This paper describes recent DIII-D high power heating and current drive experiments. Describes are experiments with improved wall conditioning, divertor particle pumping, radiative divertor experiments, studies of plasma shape and high poloidal beta

Digit Ratio (2D:4D and Gender Inequalities Across Nations

Directory of Open Access Journals (Sweden)

John T. Manning

2014-10-01

Full Text Available Gender inequality varies across nations, where such inequality is defined as the disproportionate representation of one sex over the other in desirable social, economic, and biological roles (typically male over female. Thus in Norway, 40% of parliamentarians are women, in the USA 17%, and in Saudi Arabia 0%. Some of this variation is associated with economic prosperity but there is evidence that this cause and effect can go in either direction. Here we show that within a population the average ratio of index (2D to ring (4D finger lengths (2D:4D—a proxy measure of the relative degree to which offspring is exposed in utero to testosterone versus estrogen—is correlated with measures of gender inequality between nations. We compared male and female 2D:4D ratios to female parliamentary representation, labor force participation, female education level, maternal mortality rates, and juvenile pregnancy rates per nation in a sample of 29 countries. We found those nations who showed higher than expected female fetal exposure to testosterone (low 2D:4D and lower than expected male exposure to fetal testosterone (high 2D:4D had higher rates of female parliamentary representation, and higher female labor force participation. In short, the more similar the two sexes were in 2D:4D, the more equal were the two sexes in parliamentary and labor force participation. The other variables were not as strongly correlated. We suggest that higher than expected fetal testosterone in females and lower fetal testosterone in males may lead to high female representation in the national labor force and in parliament.

B0 → D0 anti D0K0, B+ → D0 anti D0K+, and the scalar D anti D bound state

International Nuclear Information System (INIS)

Dai, L.R.; Xie, Ju-Jun; Oset, E.

2016-01-01

We study the B 0 decay to D 0 anti D 0 K 0 based on the chiral unitary approach, which generates the X(3720) resonance, and we make predictions for the D 0 anti D 0 invariant mass distribution. From the shape of the distribution, the existence of the resonance below threshold could be induced. We also predict the rate of production of the X(3720) resonance to the D 0 anti D 0 mass distribution with no free parameters. (orig.)

2D-Driven 3D Object Detection in RGB-D Images

KAUST Repository

Lahoud, Jean; Ghanem, Bernard

2017-01-01

In this paper, we present a technique that places 3D bounding boxes around objects in an RGB-D scene. Our approach makes best use of the 2D information to quickly reduce the search space in 3D, benefiting from state-of-the-art 2D object detection

3D printable highly conductive and mechanically strong thermoplastic-based nanocomposites

Science.gov (United States)

Tabiai, Ilyass; Therriault, Daniel

Highly conductive 3D printable inks can be used to design electrical devices with various functionalities and geometries. We use the solvent evaporation assisted 3D-printing method to create high resolution structures made of poly(lactid) acid (PLA) reinforced with multi-walled carbon nanotube (MWCNTs). We characterize fibers with diameters ranging between 100 μm to 330 μm and reinforced with MWCNTs from 0.5 up to 40wt% here. Tensile test, shrinkage ratio, density and electrical conductivity measurements of the printed nanocomposite are presented. The material's electrical conductivity is strongly improved by adding MWCNTs (up to 3000S/m), this value was found to be higher than any 3D-printable carbon based material available in the literature. It is observed that MWCNTs significantly increase the material's strength and stiffness while reducing its ductility. The ink's density was also higher while still being in the range of polymers' densities. The presented nanocomposite is light weight, highly conductive, has good mechanical properties and can be printed in a freeform fashion at the micro scale. A myriad of low power consumption with less resistive heating sensors and devices can potentially be designed using it and integrated into other 3D printable products.

High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers

DEFF Research Database (Denmark)

Bohr, Adam; Boetker, Johan; Wang, Yingya

2017-01-01

3D printing allows a rapid and inexpensive manufacturing of custom made and prototype devices. Micromixers are used for rapid and controlled production of nanoparticles intended for therapeutic delivery. In this study, we demonstrate the fabrication of micromixers using computational design and 3D...... via bulk mixing. Moreover, each micromixer could process more than 2 liters per hour with unaffected performance and the setup could easily be scaled-up by aligning several micromixers in parallel. This demonstrates that 3D printing can be used to prepare disposable high-throughput micromixers...... printing, which enable a continuous and industrial scale production of nanocomplexes formed by electrostatic complexation, using the polymers poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate). Several parameters including polymer concentration, flow rate, and flow ratio were...

Emulsion Inks for 3D Printing of High Porosity Materials.

Science.gov (United States)

Sears, Nicholas A; Dhavalikar, Prachi S; Cosgriff-Hernandez, Elizabeth M

2016-08-01

Photocurable emulsion inks for use with solid freeform fabrication (SFF) to generate constructs with hierarchical porosity are presented. A high internal phase emulsion (HIPE) templating technique was utilized to prepare water-in-oil emulsions from a hydrophobic photopolymer, surfactant, and water. These HIPEs displayed strong shear thinning behavior that permitted layer-by-layer deposition into complex shapes and adequately high viscosity at low shear for shape retention after extrusion. Each layer was actively polymerized with an ultraviolet cure-on-dispense (CoD) technique and compositions with sufficient viscosity were able to produce tall, complex scaffolds with an internal lattice structure and microscale porosity. Evaluation of the rheological and cure properties indicated that the viscosity and cure rate both played an important role in print fidelity. These 3D printed polyHIPE constructs benefit from the tunable pore structure of emulsion templated material and the designed architecture of 3D printing. As such, these emulsion inks can be used to create ultra high porosity constructs with complex geometries and internal lattice structures not possible with traditional manufacturing techniques. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

2D-3D rigid registration to compensate for prostate motion during 3D TRUS-guided biopsy.

Science.gov (United States)

De Silva, Tharindu; Fenster, Aaron; Cool, Derek W; Gardi, Lori; Romagnoli, Cesare; Samarabandu, Jagath; Ward, Aaron D

2013-02-01

Three-dimensional (3D) transrectal ultrasound (TRUS)-guided systems have been developed to improve targeting accuracy during prostate biopsy. However, prostate motion during the procedure is a potential source of error that can cause target misalignments. The authors present an image-based registration technique to compensate for prostate motion by registering the live two-dimensional (2D) TRUS images acquired during the biopsy procedure to a preacquired 3D TRUS image. The registration must be performed both accurately and quickly in order to be useful during the clinical procedure. The authors implemented an intensity-based 2D-3D rigid registration algorithm optimizing the normalized cross-correlation (NCC) metric using Powell's method. The 2D TRUS images acquired during the procedure prior to biopsy gun firing were registered to the baseline 3D TRUS image acquired at the beginning of the procedure. The accuracy was measured by calculating the target registration error (TRE) using manually identified fiducials within the prostate; these fiducials were used for validation only and were not provided as inputs to the registration algorithm. They also evaluated the accuracy when the registrations were performed continuously throughout the biopsy by acquiring and registering live 2D TRUS images every second. This measured the improvement in accuracy resulting from performing the registration, continuously compensating for motion during the procedure. To further validate the method using a more challenging data set, registrations were performed using 3D TRUS images acquired by intentionally exerting different levels of ultrasound probe pressures in order to measure the performance of our algorithm when the prostate tissue was intentionally deformed. In this data set, biopsy scenarios were simulated by extracting 2D frames from the 3D TRUS images and registering them to the baseline 3D image. A graphics processing unit (GPU)-based implementation was used to improve the

Vitamin D, Sunlight and Prostate Cancer Risk

Directory of Open Access Journals (Sweden)

Krishna Vanaja Donkena

2011-01-01

Full Text Available Prostate cancer is the second common cancer in men worldwide. The prevention of prostate cancer remains a challenge to researchers and clinicians. Here, we review the relationship of vitamin D and sunlight to prostate cancer risk. Ultraviolet radiation of the sunlight is the main stimulator for vitamin D production in humans. Vitamin D's antiprostate cancer activities may be involved in the actions through the pathways mediated by vitamin D metabolites, vitamin D metabolizing enzymes, vitamin D receptor (VDR, and VDR-regulated genes. Although laboratory studies including the use of animal models have shown that vitamin D has antiprostate cancer properties, whether it can effectively prevent the development and/or progression of prostate cancer in humans remains to be inconclusive and an intensively studied subject. This review will provide up-to-date information regarding the recent outcomes of laboratory and epidemiology studies on the effects of vitamin D on prostate cancer prevention.

From 2D to 3D - a new dimension for modelling the effect of natural products on human tissue

DEFF Research Database (Denmark)

Wrzesinski, Krzysztof; Fey, Stephen John

2015-01-01

to be considered, perhaps the most important, is that the compound should have the desired effect on the tissue in vivo. Since it is not possible (or ethical) to test all compounds in vivo one must preselect using a surrogate assay system. While animal models have the advantage of being holistic and current 3D...... using classical 2D culture systems. We will discuss advantages and disadvantages of these new culture technologies and highlight theoretical reasons for the differences. 3D cell culture technologies are more labour intensive than 2D culture systems and therefore their introduction is a trade-off between...

Recent DIII-D high power heating and current drive experiments

International Nuclear Information System (INIS)

Simonen, T.C.; Jackson, G.L.; Lazarus, E.A.; Mahdavi, M.A.; Petrie, T.W.; Politzer, P.A.; Taylor, T.S.

1995-01-01

This paper describes recent DIII-D high power heating and current drive experiments. Described are experiments with improved wall conditioning, divertor particle pumping, radiative divertor experiments, studies of plasma shape and high poloidal β. ((orig.))

Recent DIII-D high power heating and current drive experiments

Energy Technology Data Exchange (ETDEWEB)

Simonen, T.C. [General Atomics, San Diego, CA (United States); Jackson, G.L. [General Atomics, San Diego, CA (United States); Lazarus, E.A. [Oak Ridge National Lab., TN (United States); Mahdavi, M.A. [General Atomics, San Diego, CA (United States); Petrie, T.W. [General Atomics, San Diego, CA (United States); Politzer, P.A. [General Atomics, San Diego, CA (United States); Taylor, T.S. [General Atomics, San Diego, CA (United States); DIII-D Team

1995-01-01

This paper describes recent DIII-D high power heating and current drive experiments. Described are experiments with improved wall conditioning, divertor particle pumping, radiative divertor experiments, studies of plasma shape and high poloidal {beta}. ((orig.)).

3D radiation therapy or intensity-modulated radiotherapy for recurrent and metastatic cervical cancer: the Shanghai Cancer Hospital experience.

Directory of Open Access Journals (Sweden)

Su-Ping Liu

Full Text Available We evaluate the outcomes of irradiation by using three-dimensional radiation therapy (3D-RT or intensity-modulated radiotherapy (IMRT for recurrent and metastatic cervical cancer. Between 2007 and 2010, 50 patients with recurrent and metastatic cervical cancer were treated using 3D-RT or IMRT. The median time interval between the initial treatment and the start of irradiation was 12 (6-51 months. Salvage surgery was performed before irradiation in 5 patients, and 38 patients received concurrent chemotherapy. Sixteen patients underwent 3D-RT, and 34 patients received IMRT. Median follow-up for all the patients was 18.3 months. Three-year overall survival and locoregional control were 56.1% and 59.7%, respectively. Three-year progression-free survival and disease-free survival were 65.3% and 64.3%, respectively. Nine patients developed grade 3 leukopenia. Grade 5 acute toxicity was not observed in any of the patients; however, 2 patients developed Grade 3 late toxicity. 3D-RT or IMRT is effective for the treatment of recurrent and metastatic cervical cancer, with the 3-year overall survival of 56.1%, and its complications are acceptable. Long-term follow-up and further studies are needed to confirm the role of 3D-RT or IMRT in the multimodality management of the disease.

3D printed high performance strain sensors for high temperature applications

Science.gov (United States)

Rahman, Md Taibur; Moser, Russell; Zbib, Hussein M.; Ramana, C. V.; Panat, Rahul

2018-01-01

Realization of high temperature physical measurement sensors, which are needed in many of the current and emerging technologies, is challenging due to the degradation of their electrical stability by drift currents, material oxidation, thermal strain, and creep. In this paper, for the first time, we demonstrate that 3D printed sensors show a metamaterial-like behavior, resulting in superior performance such as high sensitivity, low thermal strain, and enhanced thermal stability. The sensors were fabricated using silver (Ag) nanoparticles (NPs), using an advanced Aerosol Jet based additive printing method followed by thermal sintering. The sensors were tested under cyclic strain up to a temperature of 500 °C and showed a gauge factor of 3.15 ± 0.086, which is about 57% higher than that of those available commercially. The sensor thermal strain was also an order of magnitude lower than that of commercial gages for operation up to a temperature of 500 °C. An analytical model was developed to account for the enhanced performance of such printed sensors based on enhanced lateral contraction of the NP films due to the porosity, a behavior akin to cellular metamaterials. The results demonstrate the potential of 3D printing technology as a pathway to realize highly stable and high-performance sensors for high temperature applications.

3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs.

Science.gov (United States)

Knowlton, Stephanie; Yu, Chu Hsiang; Ersoy, Fulya; Emadi, Sharareh; Khademhosseini, Ali; Tasoglu, Savas

2016-06-20

Three-dimensional (3D) printing offers potential to fabricate high-throughput and low-cost fabrication of microfluidic devices as a promising alternative to traditional techniques which enables efficient design iterations in the development stage. In this study, we demonstrate a single-step fabrication of a 3D transparent microfluidic chip using two alternative techniques: a stereolithography-based desktop 3D printer and a two-step fabrication using an industrial 3D printer based on polyjet technology. This method, compared to conventional fabrication using relatively expensive materials and labor-intensive processes, presents a low-cost, rapid prototyping technique to print functional 3D microfluidic chips. We enhance the capabilities of 3D-printed microfluidic devices by coupling 3D cell encapsulation and spatial patterning within photocrosslinkable gelatin methacryloyl (GelMA). The platform presented here serves as a 3D culture environment for long-term cell culture and growth. Furthermore, we have demonstrated the ability to print complex 3D microfluidic channels to create predictable and controllable fluid flow regimes. Here, we demonstrate the novel use of 3D-printed microfluidic chips as controllable 3D cell culture environments, advancing the applicability of 3D printing to engineering physiological systems for future applications in bioengineering.

A high sensitive 66 dB linear dynamic range receiver for 3-D laser radar

Science.gov (United States)

Ma, Rui; Zheng, Hao; Zhu, Zhangming

2017-08-01

This study presents a CMOS receiver chip realized in 0.18 μm standard CMOS technology and intended for high precision 3-D laser radar. The chip includes an adjustable gain transimpedance pre-amplifier, a post-amplifier and two timing comparators. An additional feedback is employed in the regulated cascode transimpedance amplifier to decrease the input impedance, and a variable gain transimpedance amplifier controlled by digital switches and analog multiplexer is utilized to realize four gain modes, extending the input dynamic range. The measurement shows that the highest transimpedance of the channel is 50 k {{Ω }}, the uncompensated walk error is 1.44 ns in a wide linear dynamic range of 66 dB (1:2000), and the input referred noise current is 2.3 pA/\\sqrt{{Hz}} (rms), resulting in a very low detectable input current of 1 μA with SNR = 5.

High resolution, large deformation 3D traction force microscopy.

Directory of Open Access Journals (Sweden)

Jennet Toyjanova

Full Text Available Traction Force Microscopy (TFM is a powerful approach for quantifying cell-material interactions that over the last two decades has contributed significantly to our understanding of cellular mechanosensing and mechanotransduction. In addition, recent advances in three-dimensional (3D imaging and traction force analysis (3D TFM have highlighted the significance of the third dimension in influencing various cellular processes. Yet irrespective of dimensionality, almost all TFM approaches have relied on a linear elastic theory framework to calculate cell surface tractions. Here we present a new high resolution 3D TFM algorithm which utilizes a large deformation formulation to quantify cellular displacement fields with unprecedented resolution. The results feature some of the first experimental evidence that cells are indeed capable of exerting large material deformations, which require the formulation of a new theoretical TFM framework to accurately calculate the traction forces. Based on our previous 3D TFM technique, we reformulate our approach to accurately account for large material deformation and quantitatively contrast and compare both linear and large deformation frameworks as a function of the applied cell deformation. Particular attention is paid in estimating the accuracy penalty associated with utilizing a traditional linear elastic approach in the presence of large deformation gradients.

Facts and Misconceptions about 2D:4D, Social and Risk Preferences

Science.gov (United States)

Alonso, Judit; Di Paolo, Roberto; Ponti, Giovanni; Sartarelli, Marcello

2018-01-01

We study how the ratio between the length of the second and fourth digit (2D:4D) correlates with choices in social and risk preferences elicitation tasks by building a large dataset from five experimental projects with more than 800 subjects. Our results confirm the recent literature that downplays the link between 2D:4D and many domains of economic interest, such as social and risk preferences. As for the former, we find that social preferences are significantly lower when 2D:4D is above the median value only for subjects with low cognitive ability. As for the latter, we find that a high 2D:4D is not correlated with the frequency of subjects' risky choices. PMID:29487510

EXPLORING THE POTENTIAL OF AERIAL PHOTOGRAMMETRY FOR 3D MODELLING OF HIGH-ALPINE ENVIRONMENTS

Directory of Open Access Journals (Sweden)

K. Legat

2016-03-01

Based on the very promising results, some general recommendations for aerial photogrammetry processing in high-alpine areas are made to achieve best possible accuracy of the final 3D-, 2.5D- and 2D products.

D-T plasma of self-sustained burning under high performance

International Nuclear Information System (INIS)

Gong Xueyu

2003-01-01

By adopting a Bohm-type thermal diffusion coefficient related to the energy confinement enhancement factor H within the conventional magnetic shear regime, and a mixed Bohm-gyro-Bohm thermal diffusion coefficient related to the shear within the negative central magnetic shear regime, considering the effect of the α particle anomalous diffusion and the dynamic feedback heating, and starting from energy transport of electrons and ions, we have studied the high performance self-sustaining burning deuterium-tritium plasma under a given plasma density profile for the two different kinds of magnetic shear regimes. Some conclusions are obtained: under the conventional shear, only when H≥3, the D-T burning can produce a large power output, and when H is larger than a certain value (H≅4), D-T plasma self-sustained burning can be maintained without the dynamic feedback heating; under the negative central shear, the plasmas have a higher plasma performance and a larger power output than that under conventional shear, and D-T plasma self-sustained burning can be maintained without the dynamic feedback heating power, the suitable alpha particle diffusion is advantage ous to D-T plasma burning under the conventional shear, and D-T self-sustained burning cannot be maintained under a large α particle anomalous diffusion for the negative central shear. The dynamic feedback heating power is important for sustaining D-T plasma burning under the conventional shear

Assessment of Hematological and Biochemical parameters with extended D-Ribose ingestion

Directory of Open Access Journals (Sweden)

Frelich Angela

2008-09-01

Full Text Available Abstract D-ribose, a naturally occurring pentose carbohydrate, has been shown to replenish high- energy phosphates following myocardial ischemia and high intensity, repetitive exercise. Human studies have mainly involved short-term assessment, including potential toxicity. Reports describing adverse effects of D-ribose with prolonged ingestion have been lacking. Therefore, this study assessed the toxicity of extended consumption of D-ribose in healthy adults. Nineteen subjects ingested 20 grams/Day (10 grams, twice a Day of ribose with serial measurements of biochemical and hematological parameters at Days 0, 7, and 14. No significant toxic changes over the 14-day assessment period occurred in complete blood count, albumin, alkaline phosphatase, gamma glutamyltransferase, alanine amiotransferase, and aspartate aminotransferase. However, D-ribose did produce an asymptomatic, mild hypoglycemia of short duration. Uric acid levels increased at Day 7, but decreased to baseline values by Day 14. D-ribose consumption for 14 days appears not to produce significant toxic changes in both hematological and biochemical parameters in healthy human volunteers.

Reusable High Aspect Ratio 3-D Nickel Shadow Mask

Science.gov (United States)

Shandhi, M.M.H.; Leber, M.; Hogan, A.; Warren, D.J.; Bhandari, R.; Negi, S.

2017-01-01

Shadow Mask technology has been used over the years for resistless patterning and to pattern on unconventional surfaces, fragile substrate and biomaterial. In this work, we are presenting a novel method to fabricate high aspect ratio (15:1) three-dimensional (3D) Nickel (Ni) shadow mask with vertical pattern length and width of 1.2 mm and 40 μm respectively. The Ni shadow mask is 1.5 mm tall and 100 μm wide at the base. The aspect ratio of the shadow mask is 15. Ni shadow mask is mechanically robust and hence easy to handle. It is also reusable and used to pattern the sidewalls of unconventional and complex 3D geometries such as microneedles or neural electrodes (such as the Utah array). The standard Utah array has 100 active sites at the tip of the shaft. Using the proposed high aspect ratio Ni shadow mask, the Utah array can accommodate 300 active sites, 200 of which will be along and around the shaft. The robust Ni shadow mask is fabricated using laser patterning and electroplating techniques. The use of Ni 3D shadow mask will lower the fabrication cost, complexity and time for patterning out-of-plane structures. PMID:29056835

Assessment of engineered surfaces roughness by high-resolution 3D SEM photogrammetry

Energy Technology Data Exchange (ETDEWEB)

Gontard, L.C., E-mail: lionelcg@gmail.com [Departamento de Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica, Universidad de Cádiz, Puerto Real 11510 (Spain); López-Castro, J.D.; González-Rovira, L. [Departamento de Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica, Escuela Superior de Ingeniería, Laboratorio de Corrosión, Universidad de Cádiz, Puerto Real 11519 (Spain); Vázquez-Martínez, J.M. [Departamento de Ingeniería Mecánica y Diseño Industrial, Escuela Superior de Ingeniería, Universidad de Cádiz, Puerto Real 11519 (Spain); Varela-Feria, F.M. [Servicio de Microscopía Centro de Investigación, Tecnología e Innovación (CITIUS), Universidad de Sevilla, Av. Reina Mercedes 4b, 41012 Sevilla (Spain); Marcos, M. [Departamento de Ingeniería Mecánica y Diseño Industrial, Escuela Superior de Ingeniería, Universidad de Cádiz, Puerto Real 11519 (Spain); and others

2017-06-15

Highlights: • We describe a method to acquire a high-angle tilt series of SEM images that is symmetrical respect to the zero tilt of the sample stage. The method can be applied in any SEM microscope. • Using the method, high-resolution 3D SEM photogrammetry can be applied on planar surfaces. • 3D models of three surfaces patterned with grooves are reconstructed with high resolution using multi-view freeware photogrammetry software as described in LC Gontard et al. Ultramicroscopy, 2016. • From the 3D models roughness parameters are measured • 3D SEM high-resolution photogrammetry is compared with two conventional methods used for roughness characetrization: stereophotogrammetry and contact profilometry. • It provides three-dimensional information with high-resolution that is out of reach for any other metrological technique. - Abstract: We describe a methodology to obtain three-dimensional models of engineered surfaces using scanning electron microscopy and multi-view photogrammetry (3DSEM). For the reconstruction of the 3D models of the surfaces we used freeware available in the cloud. The method was applied to study the surface roughness of metallic samples patterned with parallel grooves by means of laser. The results are compared with measurements obtained using stylus profilometry (PR) and SEM stereo-photogrammetry (SP). The application of 3DSEM is more time demanding than PR or SP, but it provides a more accurate representation of the surfaces. The results obtained with the three techniques are compared by investigating the influence of sampling step on roughness parameters.

SU-F-BRD-01: A Novel 4D Robust Optimization Mitigates Interplay Effect in Intensity-Modulated Proton Therapy for Lung Cancer

Energy Technology Data Exchange (ETDEWEB)

Liu, W; Shen, J; Stoker, J; Bues, M [Mayo Clinic Arizona, Phoenix, AZ (United States); Schild, S; Wong, W [Mayo Clinic, Phoenix, Arizona (United States); Chang, J; Liao, Z; Wen, Z; Sahoo, N [MD Anderson Cancer Center, Houston, TX (United States); Herman, M [Mayo Clinic, Rochester, MN (United States); Mohan, R [UT MD Anderson Cancer Center, Houston, TX (United States)

2015-06-15

Purpose: To compare the impact of interplay effect on 3D and 4D robustly optimized intensity-modulated proton therapy (IMPT) plans to treat lung cancer. Methods: Two IMPT plans were created for 11 non-small-cell-lung-cancer cases with 6–14 mm spots. 3D robust optimization generated plans on average CTs with the internal gross tumor volume density overridden to deliver 66 CGyE in 33 fractions to the internal target volume (ITV). 4D robust optimization generated plans on 4D CTs with the delivery of prescribed dose to the clinical target volume (CTV). In 4D optimization, the CTV of individual 4D CT phases received non-uniform doses to achieve a uniform cumulative dose. Dose evaluation software was developed to model time-dependent spot delivery to incorporate interplay effect with randomized starting phases of each field per fraction. Patient anatomy voxels were mapped from phase to phase via deformable image registration to score doses. Indices from dose-volume histograms were used to compare target coverage, dose homogeneity, and normal-tissue sparing. DVH indices were compared using Wilcoxon test. Results: Given the presence of interplay effect, 4D robust optimization produced IMPT plans with better target coverage and homogeneity, but slightly worse normal tissue sparing compared to 3D robust optimization (unit: Gy) [D95% ITV: 63.5 vs 62.0 (p=0.014), D5% - D95% ITV: 6.2 vs 7.3 (p=0.37), D1% spinal cord: 29.0 vs 29.5 (p=0.52), Dmean total lung: 14.8 vs 14.5 (p=0.12), D33% esophagus: 33.6 vs 33.1 (p=0.28)]. The improvement of target coverage (D95%,4D – D95%,3D) was related to the ratio RMA3/(TVx10−4), with RMA and TV being respiratory motion amplitude (RMA) and tumor volume (TV), respectively. Peak benefit was observed at ratios between 2 and 10. This corresponds to 125 – 625 cm3 TV with 0.5-cm RMA. Conclusion: 4D optimization produced more interplay-effect-resistant plans compared to 3D optimization. It is most effective when respiratory motion is modest

SU-F-BRD-01: A Novel 4D Robust Optimization Mitigates Interplay Effect in Intensity-Modulated Proton Therapy for Lung Cancer

International Nuclear Information System (INIS)

Liu, W; Shen, J; Stoker, J; Bues, M; Schild, S; Wong, W; Chang, J; Liao, Z; Wen, Z; Sahoo, N; Herman, M; Mohan, R

2015-01-01

Purpose: To compare the impact of interplay effect on 3D and 4D robustly optimized intensity-modulated proton therapy (IMPT) plans to treat lung cancer. Methods: Two IMPT plans were created for 11 non-small-cell-lung-cancer cases with 6–14 mm spots. 3D robust optimization generated plans on average CTs with the internal gross tumor volume density overridden to deliver 66 CGyE in 33 fractions to the internal target volume (ITV). 4D robust optimization generated plans on 4D CTs with the delivery of prescribed dose to the clinical target volume (CTV). In 4D optimization, the CTV of individual 4D CT phases received non-uniform doses to achieve a uniform cumulative dose. Dose evaluation software was developed to model time-dependent spot delivery to incorporate interplay effect with randomized starting phases of each field per fraction. Patient anatomy voxels were mapped from phase to phase via deformable image registration to score doses. Indices from dose-volume histograms were used to compare target coverage, dose homogeneity, and normal-tissue sparing. DVH indices were compared using Wilcoxon test. Results: Given the presence of interplay effect, 4D robust optimization produced IMPT plans with better target coverage and homogeneity, but slightly worse normal tissue sparing compared to 3D robust optimization (unit: Gy) [D95% ITV: 63.5 vs 62.0 (p=0.014), D5% - D95% ITV: 6.2 vs 7.3 (p=0.37), D1% spinal cord: 29.0 vs 29.5 (p=0.52), Dmean total lung: 14.8 vs 14.5 (p=0.12), D33% esophagus: 33.6 vs 33.1 (p=0.28)]. The improvement of target coverage (D95%,4D – D95%,3D) was related to the ratio RMA3/(TVx10−4), with RMA and TV being respiratory motion amplitude (RMA) and tumor volume (TV), respectively. Peak benefit was observed at ratios between 2 and 10. This corresponds to 125 – 625 cm3 TV with 0.5-cm RMA. Conclusion: 4D optimization produced more interplay-effect-resistant plans compared to 3D optimization. It is most effective when respiratory motion is modest

MR colonography with fecal tagging: comparison between 2D turbo FLASH and 3D FLASH sequences

International Nuclear Information System (INIS)

Papanikolaou, Nickolas; Grammatikakis, John; Maris, Thomas; Prassopoulos, Panos; Gourtsoyiannis, Nicholas; Lauenstein, Thomas

2003-01-01

The objective of this study was to compare inversion recovery turbo 2D fast low-angle shot (FLASH) and 3D FLASH sequences for fecal-tagged MR colonography studies. Fifteen consecutive patients with indications for colonoscopy underwent MR colonography with fecal tagging. An inversion recovery turbo-FLASH sequence was applied and compared in terms of artifacts presence, efficiency for masking residual stool, and colonic wall conspicuity with a fat-saturated 3D FLASH sequence. Both sequences were acquired following administration of paramagnetic contrast agent. Contrast-to-noise ratio and relative contrast between colonic wall and lumen were calculated and compared for both sequences. Turbo 2D FLASH provided fewer artifacts, higher efficiency for masking the residual stool, and colonic wall conspicuity equivalent to 3D FLASH. An inversion time of 10 ms provided homogeneously low signal intensity of the colonic lumen. Contrast to noise between colonic wall and lumen was significantly higher in the 3D FLASH images, whereas differences in relative contrast were not statistically significant. An optimized inversion-recovery 2D turbo-FLASH sequence provides better fecal tagging results and should be added to the 3D FLASH sequence when designing dark-lumen MR colonography examination protocols. (orig.)

2D and 3D impellers of centrifugal compressors - advantages, shortcomings and fields of application

Science.gov (United States)

Galerkin, Y.; Reksrin, A.; Drozdov, A.

2017-08-01

The simplified equations are presented for calculation of inlet dimensions and velocity values for impellers with three-dimensional blades located in axial and radial part of an impeller (3D impeller) and with two-dimensional blades in radial part (2D). Considerations concerning loss coefficients of 3D and 2D impellers at different design flow rate coefficients are given. The tendency of reduction of potential advantages of 3D impellers at medium and small design flow rate coefficients is shown. The data on high-efficiency compressors and stages with 2D impellers coefficients designed by the authors are presented. The reached efficiency level of 88 - 90% makes further increase of efficiency by the application of 3D impellers doubtful. CFD-analysis of stage candidates with medium flow rate coefficient with 3D and 2D impellers revealed specific problems. In some cases the constructive advantage of a 2D impeller is smaller hub ratio. It makes possible the reaching of higher efficiency. From other side, there is a positive tendency of gas turbine drive RPM increase. 3D impellers have no alternative for stages with high flow rate coefficients matching high-speed drive.

Application of parallel connected power-MOSFET elements to high current d.c. power supply

International Nuclear Information System (INIS)

Matsukawa, Tatsuya; Shioyama, Masanori; Shimada, Katsuhiro; Takaku, Taku; Neumeyer, Charles; Tsuji-Iio, Shunji; Shimada, Ryuichi

2001-01-01

The low aspect ratio spherical torus (ST), which has single turn toroidal field coil, requires the extremely high d.c. current like as 20 MA to energize the coil. Considering the ratings of such extremely high current and low voltage, power-MOSFET element is employed as the switching device for the a.c./d.c. converter of power supply. One of the advantages of power-MOSFET element is low on-state resistance, which is to meet the high current and low voltage operation. Recently, the capacity of power-MOSFET element has been increased and its on-state resistance has been decreased, so that the possibility of construction of high current and low voltage a.c./d.c. converter with parallel connected power-MOSFET elements has been growing. With the aim of developing the high current d.c. power supply using power-MOSFET, the basic characteristics of parallel operation with power-MOSFET elements are experimentally investigated. And, the synchronous rectifier type and the bi-directional self commutated type a.c./d.c. converters using parallel connected power-MOSFET elements are proposed

Low 25(OH) vitamin D concentrations in international UK track and ...

African Journals Online (AJOL)

and advocating intensive sun-block cream use, reports have also found high insufficiency ... population, and those with the fairest skin type to be, in fact, most deficient.28 ..... Kanzler M, et al. Sun protective behaviors and vitamin D levels in.

d-Fructose-Decorated Poly(ethylene imine) for Human Breast Cancer Cell Targeting.

Science.gov (United States)

Englert, Christoph; Pröhl, Michael; Czaplewska, Justyna A; Fritzsche, Carolin; Preußger, Elisabeth; Schubert, Ulrich S; Traeger, Anja; Gottschaldt, Michael

2017-08-01

The high affinity of GLUT5 transporter for d-fructose in breast cancer cells has been discussed intensely. In this contribution, high molar mass linear poly(ethylene imine) (LPEI) is functionalized with d-fructose moieties to combine the selectivity for the GLUT5 transporter with the delivery potential of PEI for genetic material. The four-step synthesis of a thiol-group bearing d-fructose enables the decoration of a cationic polymer backbone with d-fructose via thiol-ene photoaddition. The functionalization of LPEI is confirmed by 2D NMR techniques, elemental analysis, and size exclusion chromatography. Importantly, a d-fructose decoration of 16% renders the polymers water-soluble and eliminates the cytotoxicity of PEI in noncancer L929 cells, accompanied by a reduced unspecific cellular uptake of the genetic material. In contrast, the cytotoxicity as well as the cell specific uptake is increased for triple negative MDA-MB-231 breast cancer cells. Therefore, the introduction of d-fructose shows superior potential for cell targeting, which can be assumed to be GLUT5 dependent. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A 3D CZT high resolution detector for x- and gamma-ray astronomy

DEFF Research Database (Denmark)

Kuvvetli, Irfan; Budtz-Jørgensen, Carl; Zappettini, A.

2014-01-01

At DTU Space we have developed a high resolution three dimensional (3D) position sensitive CZT detector for high energy astronomy. The design of the 3D CZT detector is based on the CZT Drift Strip detector principle. The position determination perpendicular to the anode strips is performed using...

A dosimetric comparison of 3D conformal vs intensity modulated vs volumetric arc radiation therapy for muscle invasive bladder cancer

Directory of Open Access Journals (Sweden)

Foroudi Farshad

2012-07-01

Full Text Available Abstract Background To compare 3 Dimensional Conformal radiotherapy (3D-CRT with Intensity Modulated Radiotherapy (IMRT with Volumetric-Modulated Arc Therapy (VMAT for bladder cancer. Methods Radiotherapy plans for 15 patients with T2-T4N0M0 bladder cancer were prospectively developed for 3-DCRT, IMRT and VMAT using Varian Eclipse planning system. The same radiation therapist carried out all planning and the same clinical dosimetric constraints were used. 10 of the patients with well localised tumours had a simultaneous infield boost (SIB of the primary tumour planned for both IMRT and VMAT. Tumour control probabilities and normal tissue complication probabilities were calculated. Results Mean planning time for 3D-CRT, IMRT and VMAT was 30.0, 49.3, and 141.0 minutes respectively. The mean PTV conformity (CI index for 3D-CRT was 1.32, for IMRT 1.05, and for VMAT 1.05. The PTV Homogeneity (HI index was 0.080 for 3D-CRT, 0.073 for IMRT and 0.086 for VMAT. Tumour control and normal tissue complication probabilities were similar for 3D-CRT, IMRT and VMAT. The mean monitor units were 267 (range 250–293 for 3D-CRT; 824 (range 641–1083 for IMRT; and 403 (range 333–489 for VMAT (P  Conclusions VMAT is associated with similar dosimetric advantages as IMRT over 3D-CRT for muscle invasive bladder cancer. VMAT is associated with faster delivery times and less number of mean monitor units than IMRT. SIB is feasible in selected patients with localized tumours.

INEL D ampersand D long-range plan

International Nuclear Information System (INIS)

Buckland, R.J.; Kenoyer, D.J.; LaBuy, S.A.

1995-09-01

This Long-Range Plan presents the Decontamination and Dismantlement (D ampersand D) Program planning status for facilities at the Idaho National Engineering Laboratory (INEL). The plan provides a general description of the D ampersand D Program objectives, management criteria, and policy; discusses current activities; and documents the INEL D ampersand D Program cost and schedule estimate projections for the next 15 years. Appendices are included that provide INEL D ampersand D project historical information, a comprehensive descriptive summary of each current D ampersand D surplus facility, and a summary database of all INEL contaminated facilities awaiting or undergoing the facility transition process

Metal-Free 2D/2D Phosphorene/g-C3 N4 Van der Waals Heterojunction for Highly Enhanced Visible-Light Photocatalytic H2 Production.

Science.gov (United States)

Ran, Jingrun; Guo, Weiwei; Wang, Hailong; Zhu, Bicheng; Yu, Jiaguo; Qiao, Shi-Zhang

2018-04-30

The generation of green hydrogen (H 2 ) energy using sunlight is of great significance to solve the worldwide energy and environmental issues. Particularly, photocatalytic H 2 production is a highly promising strategy for solar-to-H 2 conversion. Recently, various heterostructured photocatalysts with high efficiency and good stability have been fabricated. Among them, 2D/2D van der Waals (VDW) heterojunctions have received tremendous attention, since this architecture can promote the interfacial charge separation and transfer and provide massive reactive centers. On the other hand, currently, most photocatalysts are composed of metal elements with high cost, limited reserves, and hazardous environmental impact. Hence, the development of metal-free photocatalysts is desirable. Here, a novel 2D/2D VDW heterostructure of metal-free phosphorene/graphitic carbon nitride (g-C 3 N 4 ) is fabricated. The phosphorene/g-C 3 N 4 nanocomposite shows an enhanced visible-light photocatalytic H 2 production activity of 571 µmol h -1 g -1 in 18 v% lactic acid aqueous solution. This improved performance arises from the intimate electronic coupling at the 2D/2D interface, corroborated by the advanced characterizations techniques, e.g., synchrotron-based X-ray absorption near-edge structure, and theoretical calculations. This work not only reports a new metal-free phosphorene/g-C 3 N 4 photocatalyst but also sheds lights on the design and fabrication of 2D/2D VDW heterojunction for applications in catalysis, electronics, and optoelectronics. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Direct production of D-arabinose from D-xylose by a coupling reaction using D-xylose isomerase, D-tagatose 3-epimerase and D-arabinose isomerase.

Science.gov (United States)

Sultana, Ishrat; Mizanur, Rahman Md; Takeshita, Kei; Takada, Goro; Izumori, Ken

2003-01-01

Klebsiella pneumoniae 40bXX, a mutant strain that constitutively produces D-arabinose isomerase (D-AI), was isolated through a series of repeated subcultures from the parent strain on a mineral salt medium supplemented with L-Xylose as the sole carbon source. D-AI could be efficiently immobilized on chitopearl beads. The optimum temperature for the activity of the immobilized enzyme was 40 degrees C and the enzyme was stable up to 50 degrees C. The D-Al was active at pH 10.0 and was stable in the range of pH 6.0-11.0. The enzyme required manganese ions for maximum activity. Three immobilized enzymes, D-xylose isomerase (D-XI), D-tagatose 3-epimerase (D-TE and D-AI were used for the preparation of D-arabinose from D-xylose in a coupling reaction. After completion of the reaction, degradation of D-xylulose was carried out by Saccharomyces cerevisiae. The reaction mixture containing D-Xylose, D-ribulose and the product was then separated by ion exchange column chromatography. After crystallization, the product was checked by HPLC, IR spectroscopy, NMR spectroscopy and optical rotation measurements. Finally, 2.0 g of D-arabinose could be obtained from 5 g of the substrate.

Vitamin D derivatives

International Nuclear Information System (INIS)

Deluca, H.F.; Schnoes, H.K.; Napoli, J.L.; Fivizzani, M.A.

1981-01-01

The preparation is described of specified vitamin D 3 esters containing alkyl and hydroxy groups. They can be used, in particular, for preparing radiolabeled vitamin D 3 compounds of high specific activity. (U.K.)

Can positron 2D-ACAR resolve the electronic structure of high-Tc superconductors

International Nuclear Information System (INIS)

Chan, L.P.; Lynn, K.G.; Harshman, D.R.

1992-01-01

In this paper, the authors examine the ability of the positron Two-Dimensional Angular Correlation Annihilation Radiation (2D-ACAR) technique to resolve the electronic structures of high-T c cuprate superconductors. Following a short description of the technique, discussions of the theoretical assumptions, data analysis and experimental considerations, in relation to the high-T c superconductors, are given. The authors briefly review recent 2D-ACAR experiments on YBa 2 Cu 3 O 7-x , Bi 2 Sr 2 CaCuO 8+δ and La 2-x Sr x CuO 4 . The 2D-ACAR technique is useful in resolving the band crossings associated with the layers of the superconductors that are preferentially sampled by the positrons. Together with other Fermi surface measurements (namely angle-resolved photoemission), 2D-ACAR can resolve some of the electronic structures of high-T c cuprate superconductors

A model of the enhancement of coal combustion using high intensity acoustic fields

International Nuclear Information System (INIS)

Yavuzkurt, S.; Ha, M.Y.; Koopmann, G.H.; Scaroni, A.

1989-01-01

In this paper a model for the enhancement of coal combustion in the presence of high intensity acoustics is developed. A high intensity acoustic field induces an oscillating velocity over pulverized coal particles otherwise entrained in the main gas stream, resulting in increased heat and mass transfer. The augmented heat and mass transfer coefficients, expressed as space- and time-averaged Nusselt and Sherwood numbers for the oscillating flow, were implemented in an existing computer code (PCGC-2) capable of predicting various aspects of pulverized coal combustion and gasification. Increases in the Nusselt and Sherwood numbers of about 45, 60 and 82.5% at sound pressure levels of 160, 165, and 170 dB for 100 μm coal particles were obtained due to increases in the acoustic slop velocity associated with the increased sound pressure levels. The main effect of the acoustic field was observed during the char combustion phase in a diffusionally controlled situation. A decrease in the char burnout length (time) of 15.7% at 160 dB and 30.2% at 170 dB was obtained compared to the case with no sound for the 100 μm coal particles

Low 25(OH) Vitamin D3 Levels Are Associated with Adverse Outcome in Newly-Diagnosed Intensively-Treated Adult Acute Myeloid Leukemia Patients

Science.gov (United States)

Lee, Hun Ju; Muindi, Josephia R.; Tan, Wei; Hu, Qiang; Wang, Dan; Liu, Song; Wilding, Gregory E.; Ford, Laurie A.; Sait, Sheila N.J.; Block, Annemarie W.; Adjei, Araba A.; Barcos, Maurice; Griffiths, Elizabeth A; Thompson, James E.; Wang, Eunice S.; Johnson, Candace S; Trump, Donald L.; Wetzler, Meir

2013-01-01

Background Several studies suggest that low 25(OH) vitamin D3 levels may be prognostic in some malignancies, but no studies have evaluated their impact on treatment outcome in acute myeloid leukemia (AML). Methods VD levels were evaluated in 97 consecutive newly diagnosed, intensively-treated AML patients. MicroRNA-expression profiles and single nucleotide polymorphisms (SNPs) in the 25(OH) vitamin D3 pathway genes were evaluated and correlated with 25(OH) vitamin D3 levels and treatment outcome. Results Thirty-four (35%) patients had normal 25(OH) vitamin D3 levels (32–100 ng/ml), 34 (35%) insufficient (20–31.9 ng/ml) and 29 (30%) deficient levels (<20 ng/ml). Insufficient/deficient 25(OH) vitamin D3 levels were associated with worse relapse-free survival (RFS) compared to normal vitamin D3 levels. In multivariate analyses, deficient 25(OH) vitamin D3, smoking, European LeukemiaNet Genetic Groups and white blood cell count retained their statistical significance for RFS. A number of microRNAs and SNPs were found to be associated with 25(OH) vitamin D3 level, although none remained significant after multiple test corrections; one 25(OH) vitamin D3 receptor SNP, rs10783219, was associated with lower complete remission rate (p=0.0442), shorter RFS (p=0.0058) and overall survival (p=0.0011). Conclusions It remains to be determined what role microRNA and SNP profiles play in contributing to low 25(OH) vitamin D3 level and/or outcome and whether supplementation will improve AML outcome. PMID:24166051

D-D fusion experiments using fast z pinches

International Nuclear Information System (INIS)

Spielman, R.B.; Baldwin, G.T.; Cooper, G.

1994-01-01

The development of high current (I > 10 MA) drivers provides us with a new tool for the study of neutron-producing plasmas in the thermal regime. The imploded deuterium mass (or collisionality) increases as I 2 and the ability of the driver to heat the plasma to relevant fusion temperatures improves as the power of the driver increases. Additionally, fast ( 2 fiber arrays were imploded in a fast z-pinch configuration on Sandia's Saturn facility generating up to 3 x 10 12 D-D neutrons. These experiments were designed to explore the physics of neutron-generating plasmas in a z-pinch geometry. Specifically, we intended to produce neutrons from a nearly thermal plasma where the electrons and ions have a nearly Maxwellian distribution. This is to be clearly differentiated from the more usual D-D beam-target neutrons generated in many dense plasma focus (DPF) devices

D-D fusion experiments using fast Z pinches

International Nuclear Information System (INIS)

Spielman, R.B.; Baldwin, G.T.; Cooper, G.

1998-03-01

The development of high current (I > 10 MA) drivers provides the authors with a new tool for the study of neutron-producing plasmas in the thermal regime. The imploded deuterium mass (or collisionality) increases as I 2 and the ability of the driver to heat the plasma to relevant fusion temperatures improves as the power of the driver increases. Additionally, fast ( 2 fiber arrays were imploded in a fast z-pinch configuration on Sandia's Saturn facility generating up to 3 x 10 12 D-D neutrons. These experiments were designed to explore the physics of neutron-generating plasmas in a z-pinch geometry. Specifically, the authors intended to produce neutrons from a nearly thermal plasma where the electrons and ions have a nearly Maxwellian distribution. This is to be clearly differentiated from the more usual D-D beam-target neutrons generated in many dense plasma focus (DPF) devices

Detection of infarct lesions from single MRI modality using inconsistency between voxel intensity and spatial location--a 3-D automatic approach.

Science.gov (United States)

Shen, Shan; Szameitat, André J; Sterr, Annette

2008-07-01

Detection of infarct lesions using traditional segmentation methods is always problematic due to intensity similarity between lesions and normal tissues, so that multispectral MRI modalities were often employed for this purpose. However, the high costs of MRI scan and the severity of patient conditions restrict the collection of multiple images. Therefore, in this paper, a new 3-D automatic lesion detection approach was proposed, which required only a single type of anatomical MRI scan. It was developed on a theory that, when lesions were present, the voxel-intensity-based segmentation and the spatial-location-based tissue distribution should be inconsistent in the regions of lesions. The degree of this inconsistency was calculated, which indicated the likelihood of tissue abnormality. Lesions were identified when the inconsistency exceeded a defined threshold. In this approach, the intensity-based segmentation was implemented by the conventional fuzzy c-mean (FCM) algorithm, while the spatial location of tissues was provided by prior tissue probability maps. The use of simulated MRI lesions allowed us to quantitatively evaluate the performance of the proposed method, as the size and location of lesions were prespecified. The results showed that our method effectively detected lesions with 40-80% signal reduction compared to normal tissues (similarity index > 0.7). The capability of the proposed method in practice was also demonstrated on real infarct lesions from 15 stroke patients, where the lesions detected were in broad agreement with true lesions. Furthermore, a comparison to a statistical segmentation approach presented in the literature suggested that our 3-D lesion detection approach was more reliable. Future work will focus on adapting the current method to multiple sclerosis lesion detection.

3D MODELLING OF PROPHYLACTIC FOOTWEAR FOR A HIGH ARCHED FOOT

Directory of Open Access Journals (Sweden)

COSTEA Mariana

2016-05-01

Full Text Available This article approaches the methodology of designing customized footwear for high arched foot. The authors propose to reconsider the classical structure of footwear bottom components for people with high arched foot and recommend incorporating custom components, with the role of compensation or adjustment. This study continues the authors’ research, starting from a foot’s 3D shape obtained by 3D scanning, the anthropometrical and biomechanical parameters, shoe lasts’ 3D modelling and continuing with 3D footwear design. Including customized orthosis can help to stop the evolution of abnormalities, diminishes sensations of pain during walking and improves performance in various physical activities carried out during the day, walking, running, and standing. The prophylactic footwear has to meet four main requirements: to protect the foot and ankle during walking and static; to ensure the normal resistance systems (bones, muscle and joint of the foot; to prevent the installation of irreversible structural changes by reducing stress on the foot; to contribute to increased performance in conducting regular physical activity. It is presented the steps of modelling an orthosis, a virtual simulation of its cutting process, followed by the integration and development of the insole, filling and sole for a customized shoe. Delcam Crispin CAD system and its applications for orthopaedics are used to design the bottom components of prophylactic footwear for a high arched foot.

Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status?

Science.gov (United States)

Bikle, Daniel; Bouillon, Roger; Thadhani, Ravi; Schoenmakers, Inez

2017-10-01

There is general consensus that serum 25(OH)D is the best biochemical marker for nutritional vitamin D status. Whether free 25(OH)D would be a better marker than total 25(OH)D is so far unclear. Free 25(OH)D can either be calculated based on the measurement of the serum concentrations of total 25(OH)D, vitamin D-binding protein (DBP), albumin, and the affinity between 25(OH)D and its binding proteins in physiological situations. Free 25(OH)D can also be measured directly by equilibrium dialysis, ultrafitration or immunoassays. During the vitamin D workshop held in Boston in March 2016, a debate was organized about the measurements and clinical value of free 25(OH)D, and this debate is summarized in the present manuscript. Overall there is consensus that most cells apart from the renal tubular cells are exposed to free rather than to total 25(OH)D. Therefore free 25(OH)D may be highly relevant for the local production and action of 1,25(OH) 2 D. During the debate it became clear that there is a need for standardization of measurements of serum DBP and of direct measurements of free 25(OH)D. There seems to be very limited genetic or racial differences in DBP concentrations or (probably) in the affinity of DBP for its major ligands. Therefore, free 25(OH)D is strongly correlated to total 25(OH)D in most normal populations. Appropriate studies are needed to define the clinical implications of free rather than total 25(OH)D in normal subjects and in disease states. Special attention is needed for such studies in cases of abnormal DBP concentrations or when one could expect changes in its affinity for its ligands. Copyright © 2017. Published by Elsevier Ltd.

Fiscal 1998 R and D report on femtosecond technology (power generation facility monitoring system using high- intensity X-ray pulse); 1998 nendo femuto byo technology no kenkyu kaihatsu (kokido X senb pulse riyo hatsuden shisetsu monitoring system no kenkyu kaihatsu) seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

This report reports the fiscal 1998 R and D result of Femtosecond Technology Research Association (FESTA) supported by NEDO. For creation of industrial basic technologies supporting the advanced information society in the 21st century, ultra-high speed electronics technology including new functions beyond the speed limit of conventional electronics technologies is indispensable. From such viewpoint, this R and D aims at establishment of the basic technology controlling conditions of beams and electrons in a femtosecond (10{sup -15}-10{sup -12} seconds) region. In development of the titled system, this R and D aims at generation of high-intensity X-ray pulse by interaction between femtosecond light pulse and high-density electron beam pulse, and development of measurement technology (non- stop inspection) of high-speed moving objects using such X- ray pulse. In fiscal 1998, this project succeeded in time stabilization of laser oscillators at a 100fs level and generation of low-emittance electron beam pulse through development of ultra-short pulse synchronization, laser stabilization and electron beam pulse generation technologies. (NEDO)