Epidermal segmentation in high-definition optical coherence tomography.

Science.gov (United States)

Li, Annan; Cheng, Jun; Yow, Ai Ping; Wall, Carolin; Wong, Damon Wing Kee; Tey, Hong Liang; Liu, Jiang

2015-01-01

Epidermis segmentation is a crucial step in many dermatological applications. Recently, high-definition optical coherence tomography (HD-OCT) has been developed and applied to imaging subsurface skin tissues. In this paper, a novel epidermis segmentation method using HD-OCT is proposed in which the epidermis is segmented by 3 steps: the weighted least square-based pre-processing, the graph-based skin surface detection and the local integral projection-based dermal-epidermal junction detection respectively. Using a dataset of five 3D volumes, we found that this method correlates well with the conventional method of manually marking out the epidermis. This method can therefore serve to effectively and rapidly delineate the epidermis for study and clinical management of skin diseases.

A novel three-dimensional and high-definition flexible scope.

Science.gov (United States)

Nishiyama, Kenichi; Natori, Yoshihiro; Oka, Kazunari

2014-06-01

Recent high-tech innovations in digital surgical technology have led to advances in three-dimensional (3D) and high-definition (HD) operating scopes. We introduce a novel 3D-HD flexible surgical scope called "3D-Eye-Flex" and evaluate its utility as an alternative to the operating microscope. The 3D-Eye-Flex has a 15 mm long 3D-HD scope-head with a 15 mm outer diameter, a focus distance of 18-100 mm and 80° angle of view. Attached to a 615-mm-long flexible bellows, 3D-Eye-Flex can be easily fixed to the operating table. Microsurgical dissection of wet brain tissue and drilling a skull base model were performed under the scope while using the 3D-HD video monitor. This scope system provided excellent illumination and image quality during the procedures. A large depth of field with stereoscopic vision had a greater advantage over using an operating microscope. 3D-Eye-Flex was easy to manipulate and provided an abundance of space above the operative field. Surgeons felt comfortable while working and could easily shift the position of the scope. This novel 3D-HD flexible scope is an effective alternative to the operating microscope as a new surgeon's eye and will be suitable for digital image-based surgery with further refinement.

H/D isotope effects in high temperature proton conductors

DEFF Research Database (Denmark)

Bonanos, Nikolaos; Huijser, A.; Poulsen, Finn Willy

2015-01-01

The atomic mass ratio of ca. 2 between deuterium and hydrogen is the highest for any pair of stable isotopes and results in significant and measurable H/D isotope effects in high temperature proton conductors containing these species. This paper discusses H/D isotope effects manifested in O-H/O-D...

Post-colonoscopy colorectal cancer rate in the era of high-definition colonoscopy.

Science.gov (United States)

Iwatate, Mineo; Kitagawa, Tomoyuki; Katayama, Yasumi; Tokutomi, Naohiko; Ban, Shinichi; Hattori, Santa; Hasuike, Noriaki; Sano, Wataru; Sano, Yasushi; Tamano, Masaya

2017-11-14

To investigate the post-colonoscopy colorectal cancer (PCCRC) rate for high-definition (HD) colonoscopy compared with that for standard-definition colonoscopy reported previously. Using medical records at Sano Hospital (SH) and Dokkyo Medical University Koshigaya Hospital (DMUKH), we retrospectively obtained data on consecutive patients diagnosed as having CRC between January 2010 and December 2015. The definition of PCCRC was diagnosis of CRC between 7 and 36 mo after initial high-definition colonoscopy that had detected no cancer, and patients were divided into a PCCRC group and a non-PCCRC group. The primary outcome was the rate of PCCRC for HD colonoscopy. The secondary outcomes were factors associated with PCCRC and possible reason for occurrence of early and advanced PCCRC. Among 892 CRC patients, 11 were diagnosed as having PCCRC and 881 had non-PCCRC. The PCCRC rate was 1.7% (8/471) at SH and 0.7% (3/421) at DMUKH. In comparison with the non-PCCRC group, the PCCRC group had a significantly higher preponderance of smaller tumors (39 mm vs 19 mm, P = 0.002), a shallower invasion depth (T1 rate, 25.4% vs 63.6%, P = 0.01), a non-polypoid macroscopic appearance (39.0% vs 85.7%, P = 0.02) and an earlier stage (59.7% vs 90.9%, P = 0.03). Possible reasons for PCCRC were "missed or new" in 9 patients (82%), "incomplete resection" in 1 (9%), and "inadequate examination'" in 1 (9%). Among 9 "missed or new" PCCRC, the leading cause was non-polypoid shape for early PCCRC and blinded location for advanced PCCRC. The PCCRC rate for HD colonoscopy was 0.7%-1.7%, being lower than that for standard-definition colonoscopy (1.8%-9.0%) reported previously employing the same methodology.

HD-DVD: the next consumer electronics revolution?

Science.gov (United States)

Topiwala, Pankaj N.

2003-11-01

The DVD is emerging as one of the world's favorite consumer electronics product, rapidly replacing analog videotape in the US and many other markets at prodigious rates. It is capable of offering a full feature-length, standard-definition movie in crisp rendition on TV. TV technology is itself in the midst of switching from analog to digital TV, with high-definition being the main draw. In fact, the US government has been advocating that switch over to digital TC, with both carrot and stick approaches, for nearly two decades, with only modest results--about 2% penetration. Under FCC herding, broadcasters are falling in the digital line--slowly, and sans profit. Meanwhile, delivery of HD content on portable media would be a great solution. Indeed, a new disk technology based on blue lasers is coming; but its widespread adoption may yet be four to five yeras away. But a promising new video codec--H.264/MPEG-4 AVC, the latest coding standard jointly developed by the Video Coding Experts Group (VCEG) of ITU-T and Moving Picture Experts Group (MPEG) of ISO/IEC, just might be the missing link. It offers substantial coding gains over MPEG-2, used in today's DVDs. With H.264, it appears possible to put HD movies on today's red-laser DVDs. Since consumers love DVDs, and HD--when they can see it, can H.264 and HD-DVD ignite a new revolution, now? It may have a huge impact on (H)DTV adoption rates.

High-Definition transcranial direct current stimulation in early onset epileptic encephalopathy: a case study.

Science.gov (United States)

Meiron, Oded; Gale, Rena; Namestnic, Julia; Bennet-Back, Odeya; David, Jonathan; Gebodh, Nigel; Adair, Devin; Esmaeilpour, Zeinab; Bikson, Marom

2018-01-01

Early onset epileptic encephalopathy is characterized by high daily seizure-frequency, multifocal epileptic discharges, severe psychomotor retardation, and death at infancy. Currently, there are no effective treatments to alleviate seizure frequency and high-voltage epileptic discharges in these catastrophic epilepsy cases. The current study examined the safety and feasibility of High-Definition transcranial direct current stimulation (HD-tDCS) in reducing epileptiform activity in a 30-month-old child suffering from early onset epileptic encephalopathy. HD-tDCS was administered over 10 intervention days spanning two weeks including pre- and post-intervention video-EEG monitoring. There were no serious adverse events or side effects related to the HD-tDCS intervention. Frequency of clinical seizures was not significantly reduced. However, interictal sharp wave amplitudes were significantly lower during the post-intervention period versus baseline. Vital signs and blood biochemistry remained stable throughout the entire study. These exploratory findings support the safety and feasibility of 4 × 1 HD-tDCS in early onset epileptic encephalopathy and provide the first evidence of HD-tDCS effects on paroxysmal EEG features in electroclinical cases under the age of 36 months. Extending HD-tDCS treatment may enhance electrographic findings and clinical effects.

Study on diagnosis of HD

International Nuclear Information System (INIS)

Chen Shuran; Yang Yumei; Zhang Guangli

1994-01-01

The study suggests a three-step diagnostic method for diagnosing HD. The first step is to make TgA, TmA examination; the second step is to make differential diagnosis for the cases of negative TgA, TmA through FNAB examination; the third step is to make TgA, TmA and FNAB examination for dynamic observation of controversial cases left over in the former two steps to achieve accurate diagnosis. Differential diagnosis has been made with the method in 87 cases of HD (clinical diagnosis only). The result shows that 7 cases have been diagnosed as thyropathy through comprehensive evaluation; definite diagnosis of HD has been made in 62 cases through TgA, TmA and in 77 cases through FNAB; 3 cases of negative TgA and TmA failed to accept FNAB examination, and were later diagnosed as HD through operation pathology or clinical treatment

In vivo assessment of optical properties of basal cell carcinoma and differentiation of BCC subtypes by high-definition optical coherence tomography

DEFF Research Database (Denmark)

Boone, Marc; Suppa, Mariano; Miyamoto, Makiko

2016-01-01

High-definition optical coherence tomography (HD-OCT) features of basal cell carcinoma (BCC) have recently been defined. We assessed in vivo optical properties (IV-OP) of BCC, by HD-OCT. Moreover their critical values for BCC subtype differentiation were determined. The technique of semi-log plot...

Image quality of low-dose CCTA in obese patients: impact of high-definition computed tomography and adaptive statistical iterative reconstruction.

Science.gov (United States)

Gebhard, Cathérine; Fuchs, Tobias A; Fiechter, Michael; Stehli, Julia; Stähli, Barbara E; Gaemperli, Oliver; Kaufmann, Philipp A

2013-10-01

The accuracy of coronary computed tomography angiography (CCTA) in obese persons is compromised by increased image noise. We investigated CCTA image quality acquired on a high-definition 64-slice CT scanner using modern adaptive statistical iterative reconstruction (ASIR). Seventy overweight and obese patients (24 males; mean age 57 years, mean body mass index 33 kg/m(2)) were studied with clinically-indicated contrast enhanced CCTA. Thirty-five patients underwent a standard definition protocol with filtered backprojection reconstruction (SD-FBP) while 35 patients matched for gender, age, body mass index and coronary artery calcifications underwent a novel high definition protocol with ASIR (HD-ASIR). Segment by segment image quality was assessed using a four-point scale (1 = excellent, 2 = good, 3 = moderate, 4 = non-diagnostic) and revealed better scores for HD-ASIR compared to SD-FBP (1.5 ± 0.43 vs. 1.8 ± 0.48; p ASIR as compared to 1.4 ± 0.4 mm for SD-FBP (p ASIR (388.3 ± 109.6 versus 350.6 ± 90.3 Hounsfield Units, HU; p ASIR vs. SD-ASIR respectively). Compared to a standard definition backprojection protocol (SD-FBP), a newer high definition scan protocol in combination with ASIR (HD-ASIR) incrementally improved image quality and visualization of distal coronary artery segments in overweight and obese individuals, without increasing image noise and radiation dose.

Autofluorescence and high-definition optical coherence tomography of retinal artery occlusions

OpenAIRE

Mathew, Raeba; Papavasileiou, Evangelia; Sivaprasad, Sobha

2010-01-01

Raeba Mathew, Evangelia Papavasileiou, Sobha SivaprasadLaser and Retinal Research Unit, Department of Ophthalmology, King’s College Hospital, Denmark Hill, London, UKBackground: The purpose of this study is to illustrate the fundus autofluorescence and high-definition optical coherence tomography (HD-OCT) features of acute and long-standing retinal artery occlusions.Design: Retrospective case series.Participants: Patients with acute and chronic retinal and cilioretinal artery occlus...

Imaging of basal cell carcinoma by high-definition optical coherence tomography

DEFF Research Database (Denmark)

Boone, M A L M; Norrenberg, S; Jemec, G B E

2012-01-01

With the continued development of noninvasive therapies for basal cell carcinoma (BCC) such as photodynamic therapy and immune therapies, noninvasive diagnosis and monitoring become increasingly relevant. High-definition optical coherence tomography (HD-OCT) is a high-resolution imaging tool, wit......, with micrometre resolution in both transversal and axial directions, enabling visualization of individual cells up to a depth of around 570 μm, and filling the imaging gap between conventional optical coherence tomography (OCT) and reflectance confocal microscopy (RCM)....

High-definition optical coherence tomography and reflectance confocal microscopy in the in vivo visualization of a reaction to permanent make-up.

Science.gov (United States)

Maier, T; Flaig, M J; Ruzicka, T; Berking, C; Pavicic, T

2015-03-01

After permanent make-up treatments, eczematous and granulomatous reactions may occur which need anti-inflammatory treatment. For the definite diagnosis oftentimes biopsies are recommended. In vivo imaging such as reflectance confocal microscopy (RCM) and high-definition optical coherence tomography (HD-OCT) has been successfully used in the non-invasive diagnosis of various dermatoses before. Here, we report on non-invasive imaging of a reaction towards permanent make-up in a 40-year-old woman by using HD-OCT and RCM. Both in HD-OCT and in RCM subepidermal pigment and granulomatous changes could be visualized and correlated with the histopathological findings. Regression of the lesions in response to topical steroids and intralesional injections of steroids and 5-fluorouracil is reported and treatment options are discussed. Non-invasive imaging techniques such as HD-OCT and RCM allow the visualization and localization of exogenous pigment and help in the evaluation of adverse reactions due to permanent make-up tattooing. © 2014 European Academy of Dermatology and Venereology.

In vitro experiments for the development of a high density (HD) barium sulfate contrast medium

International Nuclear Information System (INIS)

Klein, J.

1986-01-01

In vitro experiments with the high-density (HD) barium meal Falibaryt HD are described. Several charges of BaSO 4 were tested together with certain additives influencing dispersion, stability of the suspension, flowability, surface tension etc. Particle size spectra were measured by the manufacturer, VEB Fahlberg-List. With a simple PVC test plate containing several grooves simulating small details (areae gastricae) the diagnostic capabilities of the HD contrast medium were evaluated in an in vitro test. The developed barium meal Falibaryt HD is in its physical and chemical parameters comparable with Prontobario-HD, one of the best HD barium meals. (author)

Spot auto-focusing and spot auto-stigmation methods with high-definition auto-correlation function in high-resolution TEM.

Science.gov (United States)

Isakozawa, Shigeto; Fuse, Taishi; Amano, Junpei; Baba, Norio

2018-04-01

As alternatives to the diffractogram-based method in high-resolution transmission electron microscopy, a spot auto-focusing (AF) method and a spot auto-stigmation (AS) method are presented with a unique high-definition auto-correlation function (HD-ACF). The HD-ACF clearly resolves the ACF central peak region in small amorphous-thin-film images, reflecting the phase contrast transfer function. At a 300-k magnification for a 120-kV transmission electron microscope, the smallest areas used are 64 × 64 pixels (~3 nm2) for the AF and 256 × 256 pixels for the AS. A useful advantage of these methods is that the AF function has an allowable accuracy even for a low s/n (~1.0) image. A reference database on the defocus dependency of the HD-ACF by the pre-acquisition of through-focus amorphous-thin-film images must be prepared to use these methods. This can be very beneficial because the specimens are not limited to approximations of weak phase objects but can be extended to objects outside such approximations.

High-definition resolution three-dimensional imaging systems in laparoscopic radical prostatectomy: randomized comparative study with high-definition resolution two-dimensional systems.

Science.gov (United States)

Kinoshita, Hidefumi; Nakagawa, Ken; Usui, Yukio; Iwamura, Masatsugu; Ito, Akihiro; Miyajima, Akira; Hoshi, Akio; Arai, Yoichi; Baba, Shiro; Matsuda, Tadashi

2015-08-01

Three-dimensional (3D) imaging systems have been introduced worldwide for surgical instrumentation. A difficulty of laparoscopic surgery involves converting two-dimensional (2D) images into 3D images and depth perception rearrangement. 3D imaging may remove the need for depth perception rearrangement and therefore have clinical benefits. We conducted a multicenter, open-label, randomized trial to compare the surgical outcome of 3D-high-definition (HD) resolution and 2D-HD imaging in laparoscopic radical prostatectomy (LRP), in order to determine whether an LRP under HD resolution 3D imaging is superior to that under HD resolution 2D imaging in perioperative outcome, feasibility, and fatigue. One-hundred twenty-two patients were randomly assigned to a 2D or 3D group. The primary outcome was time to perform vesicourethral anastomosis (VUA), which is technically demanding and may include a number of technical difficulties considered in laparoscopic surgeries. VUA time was not significantly shorter in the 3D group (26.7 min, mean) compared with the 2D group (30.1 min, mean) (p = 0.11, Student's t test). However, experienced surgeons and 3D-HD imaging were independent predictors for shorter VUA times (p = 0.000, p = 0.014, multivariate logistic regression analysis). Total pneumoperitoneum time was not different. No conversion case from 3D to 2D or LRP to open RP was observed. Fatigue was evaluated by a simulation sickness questionnaire and critical flicker frequency. Results were not different between the two groups. Subjective feasibility and satisfaction scores were significantly higher in the 3D group. Using a 3D imaging system in LRP may have only limited advantages in decreasing operation times over 2D imaging systems. However, the 3D system increased surgical feasibility and decreased surgeons' effort levels without inducing significant fatigue.

Medical teleconferencing with high-definition video presentation on the 'usual' Internet.

Science.gov (United States)

Obuchi, Toshiro; Shima, Hiroji; Iwasaki, Akinori

2013-06-01

Although medical teleconferences on advanced academic networks have been common (Telemed J E Health 15:112-117, 1; Asian J Endosc Surg 3:185-188, 2; Surg Today 41:1579-1581, 3; Telemedicine development center of Asia. http://www.aqua.med.kyushu-u.ac.jp/eg/index.html . Accessed 6 March 2013, 4), reports regarding 'usual' Internet teleconferences or tele-lectures employing a telecommunication system for business use are very rare. Medical teleconferences and tele-lectures on the Internet were held three times between our institutions and other institutions, using the 'HD Com' made by Panasonic (HD Com. http://panasonic.biz/com/visual/ . Accessed 6 March 2013, 5), which is a high-definition telecommunication system for business tele-meeting. All of our medical telecommunications were successfully completed without any troubles. This system allows for all kinds of presentations using personal computers to be made from each station, so that discussions with high-definition surgical video presentation, which has recently been developed, could be effortlessly established despite the distance between institutions. Unlike telecommunication using advanced academic networks, this system can run without any need for specific engineering support, on the usual Internet. Medical telecommunication employing this system is likely to become common among ordinary hospitals in the near future.

Computer-aided detection of early cancer in the esophagus using HD endoscopy images

NARCIS (Netherlands)

Sommen, van der F.; Zinger, S.; Schoon, E.J.; With, de P.H.N.

2013-01-01

Esophageal cancer is the fastest rising type of cancer in the Western world. The recent development of High-Definition (HD) endoscopy has enabled the specialist physician to identify cancer at an early stage. Nevertheless, it still requires considerable effort and training to be able to recognize

Effects of High-Definition and Conventional tDCS on Response Inhibition.

Science.gov (United States)

Hogeveen, J; Grafman, J; Aboseria, M; David, A; Bikson, M; Hauner, K K

2016-01-01

Response inhibition is a critical executive function, enabling the adaptive control of behavior in a changing environment. The inferior frontal cortex (IFC) is considered to be critical for response inhibition, leading researchers to develop transcranial direct current stimulation (tDCS) montages attempting to target the IFC and improve inhibitory performance. However, conventional tDCS montages produce diffuse current through the brain, making it difficult to establish causality between stimulation of any one given brain region and resulting behavioral changes. Recently, high-definition tDCS (HD-tDCS) methods have been developed to target brain regions with increased focality relative to conventional tDCS. Remarkably few studies have utilized HD-tDCS to improve cognitive task performance, however, and no study has directly compared the behavioral effects of HD-tDCS to conventional tDCS. In the present study, participants received either HD-tDCS or conventional tDCS to the IFC during performance of a response inhibition task (stop-signal task, SST) or a control task (choice reaction time task, CRT). A third group of participants completed the same behavioral protocols, but received tDCS to a control site (mid-occipital cortex). Post-stimulation improvement in SST performance was analyzed as a function of tDCS group and the task performed during stimulation using both conventional and Bayesian parameter estimation analyses. Bayesian estimation of the effects of HD- and conventional tDCS to IFC relative to control site stimulation demonstrated enhanced response inhibition for both conditions. No improvements were found after control task (CRT) training in any tDCS condition. Results support the use of both HD- and conventional tDCS to the IFC for improving response inhibition, providing empirical evidence that HD-tDCS can be used to facilitate performance on an executive function task. Copyright © 2016 Elsevier Inc. All rights reserved.

Monte Carlo modeling and simulations of the High Definition (HD120) micro MLC and validation against measurements for a 6 MV beam

International Nuclear Information System (INIS)

Borges, C.; Zarza-Moreno, M.; Heath, E.; Teixeira, N.; Vaz, P.

2012-01-01

Purpose: The most recent Varian micro multileaf collimator (MLC), the High Definition (HD120) MLC, was modeled using the BEAMNRC Monte Carlo code. This model was incorporated into a Varian medical linear accelerator, for a 6 MV beam, in static and dynamic mode. The model was validated by comparing simulated profiles with measurements. Methods: The Varian Trilogy (2300C/D) accelerator model was accurately implemented using the state-of-the-art Monte Carlo simulation program BEAMNRC and validated against off-axis and depth dose profiles measured using ionization chambers, by adjusting the energy and the full width at half maximum (FWHM) of the initial electron beam. The HD120 MLC was modeled by developing a new BEAMNRC component module (CM), designated HDMLC, adapting the available DYNVMLC CM and incorporating the specific characteristics of this new micro MLC. The leaf dimensions were provided by the manufacturer. The geometry was visualized by tracing particles through the CM and recording their position when a leaf boundary is crossed. The leaf material density and abutting air gap between leaves were adjusted in order to obtain a good agreement between the simulated leakage profiles and EBT2 film measurements performed in a solid water phantom. To validate the HDMLC implementation, additional MLC static patterns were also simulated and compared to additional measurements. Furthermore, the ability to simulate dynamic MLC fields was implemented in the HDMLC CM. The simulation results of these fields were compared with EBT2 film measurements performed in a solid water phantom. Results: Overall, the discrepancies, with and without MLC, between the opened field simulations and the measurements using ionization chambers in a water phantom, for the off-axis profiles are below 2% and in depth-dose profiles are below 2% after the maximum dose depth and below 4% in the build-up region. On the conditions of these simulations, this tungsten-based MLC has a density of 18.7 g

Supporting autonomous vehicles by creating HD maps

Directory of Open Access Journals (Sweden)

Arpad Barsi

2017-10-01

Full Text Available Maps are constantly developing, also, the newly defined High Definition (HD maps increase the map content remarkably. They are based on three-dimensional survey, like laser scanning, and then stored in a fully new structured way to be able to support modern-day vehicles. Beyond the traditional lane based map content, they contain information about the roads’ neighbourhood. The goal of these maps is twofold. Primarily, they store the connections where the vehicles can travel with the description of the road-environment. Secondly, they efficiently support the exact vehicle positioning. The paper demonstrates the first results of a pilot study in the creation of HD map of an urban and a rural environment. The applied data collection technology was the terrestrial laser scanning, where the obtained point cloud was evaluated. The data storage has been solved by an in-house developed information storage model with the ability to help in vehicle control processes.

Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography.

Science.gov (United States)

Boone, Marc; Draye, Jean Pierre; Verween, Gunther; Pirnay, Jean-Paul; Verbeken, Gilbert; De Vos, Daniel; Rose, Thomas; Jennes, Serge; Jemec, Gregor B E; Del Marmol, Véronique

2014-10-01

While real-time 3-D evaluation of human skin constructs is needed, only 2-D non-invasive imaging techniques are available. The aim of this paper is to evaluate the potential of high-definition optical coherence tomography (HD-OCT) for real-time 3-D assessment of the epidermal splitting and decellularization. Human skin samples were incubated with four different agents: Dispase II, NaCl 1 M, sodium dodecyl sulphate (SDS) and Triton X-100. Epidermal splitting, dermo-epidermal junction, acellularity and 3-D architecture of dermal matrices were evaluated by High-definition optical coherence tomography before and after incubation. Real-time 3-D HD-OCT assessment was compared with 2-D en face assessment by reflectance confocal microscopy (RCM). (Immuno) histopathology was used as control. HD-OCT imaging allowed real-time 3-D visualization of the impact of selected agents on epidermal splitting, dermo-epidermal junction, dermal architecture, vascular spaces and cellularity. RCM has a better resolution (1 μm) than HD-OCT (3 μm), permitting differentiation of different collagen fibres, but HD-OCT imaging has deeper penetration (570 μm) than RCM imaging (200 μm). Dispase II and NaCl treatments were found to be equally efficient in the removal of the epidermis from human split-thickness skin allografts. However, a different epidermal splitting level at the dermo-epidermal junction could be observed and confirmed by immunolabelling of collagen type IV and type VII. Epidermal splitting occurred at the level of the lamina densa with dispase II and above the lamina densa (in the lamina lucida) with NaCl. The 3-D architecture of dermal papillae and dermis was more affected by Dispase II on HD-OCT which corresponded with histopathologic (orcein staining) fragmentation of elastic fibres. With SDS treatment, the epidermal removal was incomplete as remnants of the epidermal basal cell layer remained attached to the basement membrane on the dermis. With Triton X-100 treatment

In vivo assessment of optical properties of melanocytic skin lesions and differentiation of melanoma from non-malignant lesions by high-definition optical coherence tomography

DEFF Research Database (Denmark)

Boone, M A L M; Suppa, M; Dhaenens, F.

2016-01-01

One of the most challenging problems in clinical dermatology is the early detection of melanoma. Reflectance confocal microscopy (RCM) is an added tool to dermoscopy improving considerably diagnostic accuracy. However, diagnosis strongly depends on the experience of physicians. High-definition op......One of the most challenging problems in clinical dermatology is the early detection of melanoma. Reflectance confocal microscopy (RCM) is an added tool to dermoscopy improving considerably diagnostic accuracy. However, diagnosis strongly depends on the experience of physicians. High......-definition optical coherence tomography (HD-OCT) appears to offer additional structural and cellular information on melanocytic lesions complementary to that of RCM. However, the diagnostic potential of HD-OCT seems to be not high enough for ruling out the diagnosis of melanoma if based on morphology analysis...

Simplified Fiber-Wireless Distribution of HD Video in Passive and Active W-band Close Proximity Terminals

DEFF Research Database (Denmark)

Lebedev, Alexander; Rodes Lopez, Roberto; Yu, Xianbin

2012-01-01

We experimentally demonstrate uncompressed high-definition (HD) video distribution at 84 GHz Radio over Fiber link achieving up to 3 meters of wireless transmission. We experimentally emulate Metro-Access architecture by deploying single/multimode fibers. Passive and active approaches for remote...... antenna unit (RAU) are experimentally investigated. The bit error rate (BER) performance of the optical and wireless channels is reported. A successful transmission of uncompressed HD video in the W-band wireless channel is demonstrated with prospects to pave the way for application-focused fiber-wireless...

High Definition Clouds and Precipitation for advancing Climate Prediction (HD(CP)2): Large Eddy Simulation Study Over Germany

Science.gov (United States)

Dipankar, A.; Stevens, B. B.; Zängl, G.; Pondkule, M.; Brdar, S.

2014-12-01

The effect of clouds on large scale dynamics is represented in climate models through parameterization of various processes, of which the parameterization of shallow and deep convection are particularly uncertain. The atmospheric boundary layer, which controls the coupling to the surface, and which defines the scale of shallow convection, is typically 1 km in depth. Thus, simulations on a O(100 m) grid largely obviate the need for such parameterizations. By crossing this threshold of O(100m) grid resolution one can begin thinking of large-eddy simulation (LES), wherein the sub-grid scale parameterization have a sounder theoretical foundation. Substantial initiatives have been taken internationally to approach this threshold. For example, Miura et al., 2007 and Mirakawa et al., 2014 approach this threshold by doing global simulations, with (gradually) decreasing grid resolution, to understand the effect of cloud-resolving scales on the general circulation. Our strategy, on the other hand, is to take a big leap forward by fixing the resolution at O(100 m), and gradually increasing the domain size. We believe that breaking this threshold would greatly help in improving the parameterization schemes and reducing the uncertainty in climate predictions. To take this forward, the German Federal Ministry of Education and Research has initiated a project on HD(CP)2 that aims for a limited area LES at resolution O(100 m) using the new unified modeling system ICON (Zängl et al., 2014). In the talk, results from the HD(CP)2 evaluation simulation will be shown that targets high resolution simulation over a small domain around Jülich, Germany. This site is chosen because high resolution HD(CP)2 Observational Prototype Experiment took place in this region from 1.04.2013 to 31.05.2013, in order to critically evaluate the model. Nesting capabilities of ICON is used to gradually increase the resolution from the outermost domain, which is forced from the COSMO-DE data, to the

Assessing the reproducibility of high definition urethral pressure profilometry and its correlation with an air-charged system.

Science.gov (United States)

Klünder, Mario; Amend, Bastian; Sawodny, Oliver; Stenzl, Arnulf; Ederer, Michael; Kelp, Alexandra; Sievert, Karl-Dietrich; Feuer, Ronny

2017-06-01

Recently, a new urodynamic method for the assessment of stress urinary incontinence called high definition urethral pressure profilometry (HD-UPP) has been introduced. This method combines a novel microtip catheter with advanced signal processing to enable spatial data location and the reconstruction of a pressure image inside the urethra. In order to assess the reproducibility of HD-UPP data, we statistically evaluate HD-UPP datasets and compare them to data from a double balloon air-charged system. Both catheters are used on sedated female minipigs. Data from the microtip catheter are processed through a signal reconstruction algorithm, urodynamic features are extracted, and compared to the air-charged system. Reproducibility of HD-UPP data is assessed by statistically evaluating consecutive, intra-individual datasets. HD-UPP delivers results in agreement with previous comparisons of microtip and air-charged systems. The average deviation of two consecutive, intra-individual pressure images is very low at 7 cm H 2 O. HD-UPP provides physicians with detailed information on the pressure distribution inside the urethra. Through comparison with an air-charged catheter, it is shown that HD-UPP delivers results in agreement with previous studies on the comparison of microtip and air-charged catheters. It provides excellent reproducibility, as the difference between sequentially measured profiles from the same minipig is significantly lower than the one between profiles from different minipigs. © 2016 Wiley Periodicals, Inc.

Search for Exoplanets around Northern Circumpolar Stars. II. The Detection of Radial Velocity Variations in M Giant Stars HD 36384, HD 52030, and HD 208742

Energy Technology Data Exchange (ETDEWEB)

Lee, Byeong-Cheol; Jeong, Gwanghui; Han, Inwoo; Lee, Sang-Min; Kim, Kang-Min [Korea Astronomy and Space Science Institute 776, Daedeokdae-ro, Yuseong-gu, Daejeon 305-348 (Korea, Republic of); Park, Myeong-Gu; Oh, Hyeong-Il [Department of Astronomy and Atmospheric Sciences, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Mkrtichian, David E. [National Astronomical Research Institute of Thailand, Chiang Mai 50200 (Thailand); Hatzes, Artie P. [Thüringer Landessternwarte Tautenburg (TLS), Sternwarte 5, D-07778 Tautenburg (Germany); Gu, Shenghong; Bai, Jinming, E-mail: bclee@kasi.re.kr [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China)

2017-07-20

We present the detection of long-period RV variations in HD 36384, HD 52030, and HD 208742 by using the high-resolution, fiber-fed Bohyunsan Observatory Echelle Spectrograph (BOES) for the precise radial velocity (RV) survey of about 200 northern circumpolar stars. Analyses of RV data, chromospheric activity indicators, and bisector variations spanning about five years suggest that the RV variations are compatible with planet or brown dwarf companions in Keplerian motion. However, HD 36384 shows photometric variations with a period very close to that of RV variations as well as amplitude variations in the weighted wavelet Z-transform (WWZ) analysis, which argues that the RV variations in HD 36384 are from the stellar pulsations. Assuming that the companion hypothesis is correct, HD 52030 hosts a companion with minimum mass 13.3 M {sub Jup} orbiting in 484 days at a distance of 1.2 au. HD 208742 hosts a companion of 14.0 M {sub Jup} at 1.5 au with a period of 602 days. All stars are located at the asymptotic giant branch (AGB) stage on the H–R diagram after undergoing the helium flash and leaving the giant clump.With stellar radii of 53.0 R {sub ⊙} and 57.2 R {sub ⊙} for HD 52030 and HD 208742, respectively, these stars may be the largest yet, in terms of stellar radius, found to host substellar companions. However, given possible RV amplitude variations and the fact that these are highly evolved stars, the planet hypothesis is not yet certain.

KONSENTRASI DAN INTEGRASI KEPEMILIKAN PADA INDUSTRI MEDIA INTERNASIONAL DALAM PERANG FORMAT HIGH DEFINITION OPTICAL DISK

Directory of Open Access Journals (Sweden)

Fajriannoor Fanani

2016-03-01

Full Text Available High definition technology development in the entertainment industry, especially film industry, has produce classic problem about format consensus in the media industry. This situation eventually creates the so called “war of format” between the two most popular high definition formats, the Blu-ray from Sony/Hitachi and the HD DVD from Toshiba. Unlike the war of format before, for example is VHS versus Betamax war, that determinated mostly by the consumer, the format war between Blu-ray and HD DVD is strongly affect by the abilities of the companies behind the two format to consentrate and integrate their business moghul and also to make alliance between competitiors. Concentration of ownership is appears in the trend of holywood studios to merge with the bigger studios, which is creates a few conglomeration in the movie business. Integrations of business could be seen from the owners of the big studios that not only have the studios, but also many other business that relate or not with the entertainment business. And least, the alliance could be seen from this big studios alliance to support one of the format. Initially the HD DVD was on the fruitfull position because has been back up by the studios like Warner Bros, Paramount, and Universal that have more market share in US that the studios that support Blu-ray format, which is Sony, Walt Disneym and 20th Century Fox. Fortunately for Blu-ray, Sony already sells millions of PS 3 console that ingeniously could read Blu-ray disk; this means there’s already millions of Blu-ray reader device in the hand of consument, something that Toshiba could not generate. In the end, the victory of Blu-ray format is accelerate by the switching side of Warner Brothers studio to the Blu-ray follow by the others big studios. Conclusively, the success of a new technology, especially the media industry, is sometimes not depends on the quality of the technology itself. Often, the success is determined by the

High-definition optical coherence tomography - an aid to clinical practice and research in dermatology.

Science.gov (United States)

Cao, Taige; Tey, Hong Liang

2015-09-01

At present, beyond clinical assessment, the diagnosis of skin diseases is primarily made histologically. However, skin biopsies have many disadvantages, including pain, scarring, risk of infection, and sampling error. With recent advances in skin imaging technology, the clinical use of imaging methods for the practical management of skin diseases has become an option. The in vivo high-definition optical coherence tomography (HD-OCT) has recently been developed and commercialized (Skintell; Agfa, Belgium). Compared with conventional OCT, it has a higher resolution; compared with reflectance confocal microscopy, it has a shorter time for image acquisition as well as a greater penetration depth and a larger field of view. HD-OCT is promising but much work is still required to develop it from a research tool to a valuable adjunct for the noninvasive diagnosis of skin lesions. Substantial work has been done to identify HD-OCT features in various diseases but interpretation can be time-consuming and tedious. Projects aimed at automating these processes and improving image quality are currently under way. © 2015 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Feasibility and Clinical Utility of High-definition Transcranial Direct Current Stimulation in the Treatment of Persistent Hallucinations in Schizophrenia.

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Bose, A; Shivakumar, V; Chhabra, H; Parlikar, R; Sreeraj, V S; Dinakaran, D; Narayanaswamy, J C; Venkatasubramanian, G

2017-12-01

Persistent auditory verbal hallucination is a clinically significant problem in schizophrenia. Recent studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in treatment. An optimised version of tDCS, namely high-definition tDCS (HD-tDCS), uses smaller electrodes arranged in a 4x1 ring configuration and may offer more focal and predictable neuromodulation than conventional tDCS. This case report illustrates the feasibility and clinical utility of add-on HD-tDCS over the left temporoparietal junction in a 4x1 ring configuration to treat persistent auditory verbal hallucination in schizophrenia.

Polarized Disk Emission from Herbig Ae/Be Stars Observed Using Gemini Planet Imager: HD 144432, HD 150193, HD 163296, and HD 169142

Energy Technology Data Exchange (ETDEWEB)

Monnier, John D.; Aarnio, Alicia; Adams, Fred C.; Calvet, Nuria; Hartmann, Lee [Astronomy Department, University of Michigan, Ann Arbor, MI 48109 (United States); Harries, Tim J.; Hinkley, Sasha; Kraus, Stefan [University of Exeter, Exeter (United Kingdom); Andrews, Sean; Wilner, David [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 91023 (United States); Espaillat, Catherine [Boston University, Boston, MA (United States); McClure, Melissa [European Southern Observatory, Garching (Germany); Oppenheimer, Rebecca [American Museum of Natural History, New York (United States); Perrin, Marshall [Space Telescope Science Institute, Baltimore, MD (United States)

2017-03-20

In order to look for signs of ongoing planet formation in young disks, we carried out the first J -band polarized emission imaging of the Herbig Ae/Be stars HD 150193, HD 163296, and HD 169142 using the Gemini Planet Imager, along with new H band observations of HD 144432. We confirm the complex “double ring” structure for the nearly face-on system HD 169142 first seen in H -band, finding the outer ring to be substantially redder than the inner one in polarized intensity. Using radiative transfer modeling, we developed a physical model that explains the full spectral energy distribution and J - and H -band surface brightness profiles, suggesting that the differential color of the two rings could come from reddened starlight traversing the inner wall and may not require differences in grain properties. In addition, we clearly detect an elongated, off-center ring in HD 163296 (MWC 275), locating the scattering surface to be 18 au above the midplane at a radial distance of 77 au, co-spatial with a ring seen at 1.3 mm by ALMA linked to the CO snow line. Lastly, we report a weak tentative detection of scattered light for HD 150193 (MWC 863) and a non-detection for HD 144432; the stellar companion known for each of these targets has likely disrupted the material in the outer disk of the primary star. For HD 163296 and HD 169142, the prominent outer rings we detect could be evidence for giant planet formation in the outer disk or a manifestation of large-scale dust growth processes possibly related to snow-line chemistry.

Polarized Disk Emission from Herbig Ae/Be Stars Observed Using Gemini Planet Imager: HD 144432, HD 150193, HD 163296, and HD 169142

International Nuclear Information System (INIS)

Monnier, John D.; Aarnio, Alicia; Adams, Fred C.; Calvet, Nuria; Hartmann, Lee; Harries, Tim J.; Hinkley, Sasha; Kraus, Stefan; Andrews, Sean; Wilner, David; Espaillat, Catherine; McClure, Melissa; Oppenheimer, Rebecca; Perrin, Marshall

2017-01-01

In order to look for signs of ongoing planet formation in young disks, we carried out the first J -band polarized emission imaging of the Herbig Ae/Be stars HD 150193, HD 163296, and HD 169142 using the Gemini Planet Imager, along with new H band observations of HD 144432. We confirm the complex “double ring” structure for the nearly face-on system HD 169142 first seen in H -band, finding the outer ring to be substantially redder than the inner one in polarized intensity. Using radiative transfer modeling, we developed a physical model that explains the full spectral energy distribution and J - and H -band surface brightness profiles, suggesting that the differential color of the two rings could come from reddened starlight traversing the inner wall and may not require differences in grain properties. In addition, we clearly detect an elongated, off-center ring in HD 163296 (MWC 275), locating the scattering surface to be 18 au above the midplane at a radial distance of 77 au, co-spatial with a ring seen at 1.3 mm by ALMA linked to the CO snow line. Lastly, we report a weak tentative detection of scattered light for HD 150193 (MWC 863) and a non-detection for HD 144432; the stellar companion known for each of these targets has likely disrupted the material in the outer disk of the primary star. For HD 163296 and HD 169142, the prominent outer rings we detect could be evidence for giant planet formation in the outer disk or a manifestation of large-scale dust growth processes possibly related to snow-line chemistry.

Study of high-definition and stereoscopic head-aimed vision for improved teleoperation of an unmanned ground vehicle

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Tyczka, Dale R.; Wright, Robert; Janiszewski, Brian; Chatten, Martha Jane; Bowen, Thomas A.; Skibba, Brian

2012-06-01

Nearly all explosive ordnance disposal robots in use today employ monoscopic standard-definition video cameras to relay live imagery from the robot to the operator. With this approach, operators must rely on shadows and other monoscopic depth cues in order to judge distances and object depths. Alternatively, they can contact an object with the robot's manipulator to determine its position, but that approach carries with it the risk of detonation from unintentionally disturbing the target or nearby objects. We recently completed a study in which high-definition (HD) and stereoscopic video cameras were used in addition to conventional standard-definition (SD) cameras in order to determine if higher resolutions and/or stereoscopic depth cues improve operators' overall performance of various unmanned ground vehicle (UGV) tasks. We also studied the effect that the different vision modes had on operator comfort. A total of six different head-aimed vision modes were used including normal-separation HD stereo, SD stereo, "micro" (reduced separation) SD stereo, HD mono, and SD mono (two types). In general, the study results support the expectation that higher resolution and stereoscopic vision aid UGV teleoperation, but the degree of improvement was found to depend on the specific task being performed; certain tasks derived notably more benefit from improved depth perception than others. This effort was sponsored by the Joint Ground Robotics Enterprise under Robotics Technology Consortium Agreement #69-200902 T01. Technical management was provided by the U.S. Air Force Research Laboratory's Robotics Research and Development Group at Tyndall AFB, Florida.

Can optical diagnosis of small colon polyps be accurate? Comparing standard scope without narrow banding to high definition scope with narrow banding.

Science.gov (United States)

Ashktorab, Hassan; Etaati, Firoozeh; Rezaeean, Farahnaz; Nouraie, Mehdi; Paydar, Mansour; Namin, Hassan Hassanzadeh; Sanderson, Andrew; Begum, Rehana; Alkhalloufi, Kawtar; Brim, Hassan; Laiyemo, Adeyinka O

2016-07-28

To study the accuracy of using high definition (HD) scope with narrow band imaging (NBI) vs standard white light colonoscope without NBI (ST), to predict the histology of the colon polyps, particularly those high definition colonoscopes with NBI. The histopathologic diagnosis was reported by pathologists as part of routine care. Of participants in the study, 55 (37%) were male and median (interquartile range) of age was 56 (19-80). Demographic, clinical characteristics, past medical history of patients, and the data obtained by two instruments were not significantly different and two methods detected similar number of polyps. In ST scope 89% of polyps were scope (P = 0.7). The ST scope had a positive predictive value (PPV) and positive likelihood ratio (PLR) of 86% and 4.0 for adenoma compared to 74% and 2.6 for HD scope. There was a trend of higher sensitivity for HD scope (68%) compare to ST scope (53%) with almost the same specificity. The ST scope had a PPV and PLR of 38% and 1.8 for hyperplastic polyp (HPP) compared to 42% and 2.2 for HD scope. The sensitivity and specificity of two instruments for HPP diagnosis were similar. Our results indicated that HD scope was more sensitive in diagnosis of adenoma than ST scope. Clinical diagnosis of HPP with either scope is less accurate compared to adenoma. Colonoscopy diagnosis is not yet fully matched with pathologic diagnosis of colon polyp. However with the advancement of both imaging and training, it may be possible to increase the sensitivity and specificity of the scopes and hence save money for eliminating time and the cost of Immunohistochemistry/pathology.

Automatic and manual segmentation of healthy retinas using high-definition optical coherence tomography.

Science.gov (United States)

Golbaz, Isabelle; Ahlers, Christian; Goesseringer, Nina; Stock, Geraldine; Geitzenauer, Wolfgang; Prünte, Christian; Schmidt-Erfurth, Ursula Margarethe

2011-03-01

This study compared automatic- and manual segmentation modalities in the retina of healthy eyes using high-definition optical coherence tomography (HD-OCT). Twenty retinas in 20 healthy individuals were examined using an HD-OCT system (Carl Zeiss Meditec, Inc.). Three-dimensional imaging was performed with an axial resolution of 6 μm at a maximum scanning speed of 25,000 A-scans/second. Volumes of 6 × 6 × 2 mm were scanned. Scans were analysed using a matlab-based algorithm and a manual segmentation software system (3D-Doctor). The volume values calculated by the two methods were compared. Statistical analysis revealed a high correlation between automatic and manual modes of segmentation. The automatic mode of measuring retinal volume and the corresponding three-dimensional images provided similar results to the manual segmentation procedure. Both methods were able to visualize retinal and subretinal features accurately. This study compared two methods of assessing retinal volume using HD-OCT scans in healthy retinas. Both methods were able to provide realistic volumetric data when applied to raster scan sets. Manual segmentation methods represent an adequate tool with which to control automated processes and to identify clinically relevant structures, whereas automatic procedures will be needed to obtain data in larger patient populations. © 2009 The Authors. Journal compilation © 2009 Acta Ophthalmol.

Sex Mediates the Effects of High-Definition Transcranial Direct Current Stimulation on "Mind-Reading".

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Martin, A K; Huang, J; Hunold, A; Meinzer, M

2017-12-16

Sex differences in social cognitive ability are well established, including measures of Theory of Mind (ToM). The aim of this study was to investigate if sex mediates the effects of high-definition transcranial direct current stimulation (HD-tDCS) administered to a key hub of the social brain (i.e., the dorsomedial prefrontal cortex, dmPFC) on the Reading the Mind in the Eyes Test (RMET). Forty healthy young adults (18-35 years) were randomly allocated to receive either anodal or cathodal HD-tDCS in sham HD-tDCS controlled, double blind designs. In each of the two sessions, subjects completed the RMET. Anodal stimulation to the dmPFC increased accuracy on the RMET in females only. To assure regional specificity we performed a follow-up study stimulating the right temporoparietal junction and found no effect in either sex. The current study is the first to show improved performance on the RMET after tDCS to the dmPFC in females only. The polarity-specific effects and use of focal HD-tDCS provide evidence for sex-dependent differences in dmPFC function in relation to the RMET. Future studies using tDCS to study or improve ToM, need to consider sex. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

Automated choroid segmentation based on gradual intensity distance in HD-OCT images.

Science.gov (United States)

Chen, Qiang; Fan, Wen; Niu, Sijie; Shi, Jiajia; Shen, Honglie; Yuan, Songtao

2015-04-06

The choroid is an important structure of the eye and plays a vital role in the pathology of retinal diseases. This paper presents an automated choroid segmentation method for high-definition optical coherence tomography (HD-OCT) images, including Bruch's membrane (BM) segmentation and choroidal-scleral interface (CSI) segmentation. An improved retinal nerve fiber layer (RNFL) complex removal algorithm is presented to segment BM by considering the structure characteristics of retinal layers. By analyzing the characteristics of CSI boundaries, we present a novel algorithm to generate a gradual intensity distance image. Then an improved 2-D graph search method with curve smooth constraints is used to obtain the CSI segmentation. Experimental results with 212 HD-OCT images from 110 eyes in 66 patients demonstrate that the proposed method can achieve high segmentation accuracy. The mean choroid thickness difference and overlap ratio between our proposed method and outlines drawn by experts was 6.72µm and 85.04%, respectively.

Interobserver variability and accuracy of high-definition endoscopic diagnosis for gastric intestinal metaplasia among experienced and inexperienced endoscopists.

Science.gov (United States)

Hyun, Yil Sik; Han, Dong Soo; Bae, Joong Ho; Park, Hye Sun; Eun, Chang Soo

2013-05-01

Accurate diagnosis of gastric intestinal metaplasia is important; however, conventional endoscopy is known to be an unreliable modality for diagnosing gastric intestinal metaplasia (IM). The aims of the study were to evaluate the interobserver variation in diagnosing IM by high-definition (HD) endoscopy and the diagnostic accuracy of this modality for IM among experienced and inexperienced endoscopists. Selected 50 cases, taken with HD endoscopy, were sent for a diagnostic inquiry of gastric IM through visual inspection to five experienced and five inexperienced endoscopists. The interobserver agreement between endoscopists was evaluated to verify the diagnostic reliability of HD endoscopy in diagnosing IM, and the diagnostic accuracy, sensitivity, and specificity were evaluated for validity of HD endoscopy in diagnosing IM. Interobserver agreement among the experienced endoscopists was "poor" (κ = 0.38) and it was also "poor" (κ = 0.33) among the inexperienced endoscopists. The diagnostic accuracy of the experienced endoscopists was superior to that of the inexperienced endoscopists (P = 0.003). Since diagnosis through visual inspection is unreliable in the diagnosis of IM, all suspicious areas for gastric IM should be considered to be biopsied. Furthermore, endoscopic experience and education are needed to raise the diagnostic accuracy of gastric IM.

Effects of Hd2 in the presence of the photoperiod-insensitive functional allele of Hd1 in rice

Directory of Open Access Journals (Sweden)

Zhen-Hua Zhang

2016-11-01

Full Text Available The role of photoperiod sensitivity (PS of flowering genes have become well recognized in rice, whereas little attention has been drawn to the non-PS component of these genes, especially to their influence on gene-by-gene interactions. Rice populations in which the photoperiod-sensitive allele at Hd1 has become insensitive to photoperiod but continued to affect heading date (HD were used in this study to fine-map a quantitative trait locus (QTL for HD and analyze its genetic relationship to Hd1. The QTL was delimitated to a 96.3-kb region on the distal end of the long arm of chromosome 7. Sequence comparison revealed that this QTL is identical to Hd2. In the near-isogenic line (NIL populations analyzed, Hd1 and Hd2 were shown to be photoperiod insensitive and have pleiotropic effects for HD, plant height and yield traits. The two genes were found to largely act additively in regulating HD and yield traits. The results indicate that non-PS components of flowering genes involved in photoperiod response play an important role in controlling flowering time and grain yield in rice, which should allow breeders to better manipulate pleiotropic genes for balancing adaptability and high-yielding accumulation.

Effects of HD-tDCS on memory and metamemory for general knowledge questions that vary by difficulty

Science.gov (United States)

Chua, Elizabeth F.; Ahmed, Rifat; Garcia, Sandry

2016-01-01

Background The ability to monitor one’s own memory is an important feature of normal memory and is an aspect of ‘metamemory’. Lesion studies have shown dissociations between memory and metamemory, but only single dissociations have been shown using transcranial direct current stimulation (tDCS). One potential reason that only single dissociations have been shown is that tDCS effects may be moderated by task difficulty. Objective/Hypothesis We used high definition (HD) tDCS to test for dissociable roles of the dorsolateral prefrontal cortex (DLPFC) and anterior temporal lobe (ATL) in semantic long-term memory and metamemory tasks. We also tested whether general knowledge question difficulty moderated the effects of HD-tDCS. Methods Across 3 sessions, participants received active HD-tDCS over the left DLPFC or left ATL, or sham HD-tDCS during general knowledge recall and recognition tests, and a ‘feeling-of-knowing’ metamemory task. General knowledge questions were blocked by difficulty. Repeated measures ANOVAs were used to examine the effects of HD-tDCS on memory and metamemory tasks by memory question difficulty. Results HD-tDCS over the ATL led to improved recall compared to DLPFC and sham HD-tDCS, and this occurred only for medium difficulty questions. In contrast, for non-recalled questions, HD-tDCS over the DLPFC led to improved recognition accuracy and improved feeling-of-knowing accuracy compared to ATL and sham HD-tDCS, and this was not moderated by memory question difficulty. Conclusion(s) HD-tDCS can be used to dissociate the roles of the ATL and DLPFC in different memory and ‘metamemory’ tasks. The effects of HD-tDCS on task may be moderated by task difficulty, depending on the nature of the task and site of stimulation. PMID:27876306

Infrared absorption spectra of gaseous HD. II. Collision-induced fundamental band of HD in HD--Ne and HD--Ar mixtures at room temperature

International Nuclear Information System (INIS)

Prasad, R.D.G.; Reddy, S.P.

1976-01-01

The collision-induced infrared absorption spectra of the fundamental band of HD in binary mixtures of HD with Ne and Ar at room temperature have been studied with an absorption path length of 105.2 cm for different base densities of HD in the range 8--20 amagat and a number of total gas densities up to 175 amagat. The observed features of the profiles of the enhancement of absorption in these mixtures resemble closely those of the corresponding profiles of the fundamental band of H 2 in binary mixtures with Ne and Ar. The binary absorption coefficients of the band obtained from the measured integrated intensities are (1.84 +- 0.06) x 10 -35 and (4.41 +- 0.06) x 10 -35 cm 6 s -1 for HD--Ne and HD--Ar, respectively. The characteristic half-width parameters, delta/subd/ and delta/subc/ of the overlap transitions and delta/subq/ (and delta/subq//sub prime/) of the quadrupolar transitions, are obtained from an analysis of the profiles of the enhancement of absorption in both these mixtures. The quantity delta/subc/ which is the half-width of the intercollisional interference dip of the Q branch increases with the density of the perturbing gas Ne or Ar, and for HD--Ne it varies in a manner similar to that for HD--He as described in Paper I of this series

Accurate effective temperatures of the metal-poor benchmark stars HD 140283, HD 122563, and HD 103095 from CHARA interferometry

Science.gov (United States)

Karovicova, I.; White, T. R.; Nordlander, T.; Lind, K.; Casagrande, L.; Ireland, M. J.; Huber, D.; Creevey, O.; Mourard, D.; Schaefer, G. H.; Gilmore, G.; Chiavassa, A.; Wittkowski, M.; Jofré, P.; Heiter, U.; Thévenin, F.; Asplund, M.

2018-03-01

Large stellar surveys of the Milky Way require validation with reference to a set of `benchmark' stars whose fundamental properties are well determined. For metal-poor benchmark stars, disagreement between spectroscopic and interferometric effective temperatures has called the reliability of the temperature scale into question. We present new interferometric measurements of three metal-poor benchmark stars, HD 140283, HD 122563, and HD 103095, from which we determine their effective temperatures. The angular sizes of all the stars were determined from observations with the PAVO beam combiner at visible wavelengths at the CHARA array, with additional observations of HD 103095 made with the VEGA instrument, also at the CHARA array. Together with photometrically derived bolometric fluxes, the angular diameters give a direct measurement of the effective temperature. For HD 140283, we find θLD = 0.324 ± 0.005 mas, Teff = 5787 ± 48 K; for HD 122563, θLD = 0.926 ± 0.011 mas, Teff = 4636 ± 37 K; and for HD 103095, θLD = 0.595 ± 0.007 mas, Teff = 5140 ± 49 K. Our temperatures for HD 140283 and HD 103095 are hotter than the previous interferometric measurements by 253 and 322 K, respectively. We find good agreement between our temperatures and recent spectroscopic and photometric estimates. We conclude some previous interferometric measurements have been affected by systematic uncertainties larger than their quoted errors.

Focal Hemodynamic Responses in the Stimulated Hemisphere During High-Definition Transcranial Direct Current Stimulation.

Science.gov (United States)

Muthalib, Makii; Besson, Pierre; Rothwell, John; Perrey, Stéphane

2017-07-17

High-definition transcranial direct current stimulation (HD-tDCS) using a 4 × 1 electrode montage has been previously shown using modeling and physiological studies to constrain the electric field within the spatial extent of the electrodes. The aim of this proof-of-concept study was to determine if functional near-infrared spectroscopy (fNIRS) neuroimaging can be used to determine a hemodynamic correlate of this 4 × 1 HD-tDCS electric field on the brain. In a three session cross-over study design, 13 healthy males received one sham (2 mA, 30 sec) and two real (HD-tDCS-1 and HD-tDCS-2, 2 mA, 10 min) anodal HD-tDCS targeting the left M1 via a 4 × 1 electrode montage (anode on C3 and 4 return electrodes 3.5 cm from anode). The two real HD-tDCS sessions afforded a within-subject replication of the findings. fNIRS was used to measure changes in brain hemodynamics (oxygenated hemoglobin integral-O 2 Hb int ) during each 10 min session from two regions of interest (ROIs) in the stimulated left hemisphere that corresponded to "within" (L in ) and "outside" (L out ) the spatial extent of the 4 × 1 electrode montage, and two corresponding ROIs (R in and R out ) in the right hemisphere. The ANOVA showed that both real anodal HD-tDCS compared to sham induced a significantly greater O 2 Hb int in the L in than L out ROIs of the stimulated left hemisphere; while there were no significant differences between the real and sham sessions for the right hemisphere ROIs. Intra-class correlation coefficients showed "fair-to-good" reproducibility for the left stimulated hemisphere ROIs. The greater O 2 Hb int "within" than "outside" the spatial extent of the 4 × 1 electrode montage represents a hemodynamic correlate of the electrical field distribution, and thus provides a prospective reliable method to determine the dose of stimulation that is necessary to optimize HD-tDCS parameters in various applications. © 2017 International Neuromodulation Society.

Signal processing in urodynamics: towards high definition urethral pressure profilometry.

Science.gov (United States)

Klünder, Mario; Sawodny, Oliver; Amend, Bastian; Ederer, Michael; Kelp, Alexandra; Sievert, Karl-Dietrich; Stenzl, Arnulf; Feuer, Ronny

2016-03-22

Urethral pressure profilometry (UPP) is used in the diagnosis of stress urinary incontinence (SUI) which is a significant medical, social, and economic problem. Low spatial pressure resolution, common occurrence of artifacts, and uncertainties in data location limit the diagnostic value of UPP. To overcome these limitations, high definition urethral pressure profilometry (HD-UPP) combining enhanced UPP hardware and signal processing algorithms has been developed. In this work, we present the different signal processing steps in HD-UPP and show experimental results from female minipigs. We use a special microtip catheter with high angular pressure resolution and an integrated inclination sensor. Signals from the catheter are filtered and time-correlated artifacts removed. A signal reconstruction algorithm processes pressure data into a detailed pressure image on the urethra's inside. Finally, the pressure distribution on the urethra's outside is calculated through deconvolution. A mathematical model of the urethra is contained in a point-spread-function (PSF) which is identified depending on geometric and material properties of the urethra. We additionally investigate the PSF's frequency response to determine the relevant frequency band for pressure information on the urinary sphincter. Experimental pressure data are spatially located and processed into high resolution pressure images. Artifacts are successfully removed from data without blurring other details. The pressure distribution on the urethra's outside is reconstructed and compared to the one on the inside. Finally, the pressure images are mapped onto the urethral geometry calculated from inclination and position data to provide an integrated image of pressure distribution, anatomical shape, and location. With its advanced sensing capabilities, the novel microtip catheter collects an unprecedented amount of urethral pressure data. Through sequential signal processing steps, physicians are provided with

Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence.

Directory of Open Access Journals (Sweden)

Sharnel Perera

Full Text Available While the profiling of subtypes of Attention Deficit Hyperactivity Disorder (AD/HD have been the subject of considerable scrutiny, both psychometrically and psychophysiologically, little attention has been paid to the effect of diagnoses comorbid with AD/HD on such profiles. This is despite the greater than 80% prevalence of comorbidity under the DSM-IV-TR diagnostic definitions. Here we investigate the event related potential (ERP and psychometric profiles of Controls, AD/HD, and comorbid AD/HD (particularly AD/HD+ODD/CD groups on six neurocognitive tasks thought to probe the constructs of selective and sustained attention, response inhibition and executive function. Data from 29 parameters extracted from a child group (age range 6 to 12; 52 Controls and 64 AD/HD and from an adolescent group (age range 13 to 17; 79 Controls and 88 AD/HD were reduced via a Principal Components Analysis, the 6 significant eigenvectors then used as determinants of cluster membership via a Two-Step Cluster Analysis. Two clusters were found in the analysis of the adolescent age group--a cluster dominated by Control and AD/HD participants without comorbidity, while the second cluster was dominated by AD/HD participants with externalising comorbidity (largely oppositional defiant/conduct disorder ODD/CD. A similar segregation within the child age group was not found. Further analysis of these objectively determined clusters in terms of their clinical diagnoses indicates a significant effect of ODD/CD comorbidity on a concurrent AD/HD diagnosis. We conclude that comorbid externalising behaviour in AD/HD constitutes a distinct pathological entity in adolescence.

Detection of planet candidates around K giants. HD 40956, HD 111591, and HD 113996

Science.gov (United States)

Jeong, G.; Lee, B.-C.; Han, I.; Omiya, M.; Izumiura, H.; Sato, B.; Harakawa, H.; Kambe, E.; Mkrtichian, D.

2018-02-01

Aims: The purpose of this paper is to detect and investigate the nature of long-term radial velocity (RV) variations of K-type giants and to confirm planetary companions around the stars. Methods: We have conducted two planet search programs by precise RV measurement using the 1.8 m telescope at Bohyunsan Optical Astronomy Observatory (BOAO) and the 1.88 m telescope at Okayama Astrophysical Observatory (OAO). The BOAO program searches for planets around 55 early K giants. The OAO program is looking for 190 G-K type giants. Results: In this paper, we report the detection of long-period RV variations of three K giant stars, HD 40956, HD 111591, and HD 113996. We investigated the cause of the observed RV variations and conclude the substellar companions are most likely the cause of the RV variations. The orbital analyses yield P = 578.6 ± 3.3 d, m sin i = 2.7 ± 0.6 MJ, a = 1.4 ± 0.1 AU for HD 40956; P = 1056.4 ± 14.3 d, m sin i = 4.4 ± 0.4 MJ, a = 2.5 ± 0.1 AU for HD 111591; P = 610.2 ± 3.8 d, m sin i = 6.3 ± 1.0 MJ, a = 1.6 ± 0.1 AU for HD 113996. Based on observations made with the BOES at BOAO in Korea and HIDES at OAO in Japan.Tables 3-5 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/610/A3

High-Definition and Non-Invasive Brain Modulation of Pain and Motor Dysfunction in Chronic TMD

Science.gov (United States)

Donnell, Adam; Nascimento, Thiago; Lawrence, Mara; Gupta, Vikas; Zieba, Tina; Truong, Dennis Q.; Bikson, Marom; Datta, Abhi; Bellile, Emily; DaSilva, Alexandre F.

2015-01-01

Background Temporomandibular disorders (TMD) have a relatively high prevalence and in many patients pain and masticatory dysfunction persist despite a range of treatments. Non-invasive brain neuromodulatory methods, namely transcranial direct current stimulation (tDCS), can provide relatively long-lasting pain relief in chronic pain patients. Objective To define the neuromodulatory effect of five daily 2×2 motor cortex high-definition tDCS (HD-tDCS) sessions on clinical pain and motor measures in chronic TMD patients. It is predicted that M1 HD-tDCS will selectively modulate clinical measures, by showing greater analgesic after-effects compared to placebo, and active treatment will increase pain free jaw movement more than placebo. Methods Twenty-four females with chronic myofascial TMD pain underwent five daily, 20-minute sessions of active or sham 2 milliamps (mA) HD-tDCS. Measurable outcomes included pain-free mouth opening, visual analog scale (VAS), sectional sensory-discriminative pain measures tracked by a mobile application, short form of the McGill Pain Questionnaire, and the Positive and Negative Affect Schedule. Follow-up occurred at one-week and four-weeks post treatment. Results There were significant improvements for clinical pain and motor measurements in the active HD-tDCS group compared to the placebo group for: responders with pain relief above 50% in the VAS at four-week follow-up (p=0.04); pain-free mouth opening at one-week follow-up (ppain area, intensity and their sum measures contralateral to putative M1 stimulation during the treatment week (ppain and motor measures during stimulation, and up to four weeks post-treatment in chronic myofascial TMD pain patients. PMID:26226938

Interobserver Variability and Accuracy of High-Definition Endoscopic Diagnosis for Gastric Intestinal Metaplasia among Experienced and Inexperienced Endoscopists

Science.gov (United States)

Hyun, Yil Sik; Bae, Joong Ho; Park, Hye Sun; Eun, Chang Soo

2013-01-01

Accurate diagnosis of gastric intestinal metaplasia is important; however, conventional endoscopy is known to be an unreliable modality for diagnosing gastric intestinal metaplasia (IM). The aims of the study were to evaluate the interobserver variation in diagnosing IM by high-definition (HD) endoscopy and the diagnostic accuracy of this modality for IM among experienced and inexperienced endoscopists. Selected 50 cases, taken with HD endoscopy, were sent for a diagnostic inquiry of gastric IM through visual inspection to five experienced and five inexperienced endoscopists. The interobserver agreement between endoscopists was evaluated to verify the diagnostic reliability of HD endoscopy in diagnosing IM, and the diagnostic accuracy, sensitivity, and specificity were evaluated for validity of HD endoscopy in diagnosing IM. Interobserver agreement among the experienced endoscopists was "poor" (κ = 0.38) and it was also "poor" (κ = 0.33) among the inexperienced endoscopists. The diagnostic accuracy of the experienced endoscopists was superior to that of the inexperienced endoscopists (P = 0.003). Since diagnosis through visual inspection is unreliable in the diagnosis of IM, all suspicious areas for gastric IM should be considered to be biopsied. Furthermore, endoscopic experience and education are needed to raise the diagnostic accuracy of gastric IM. PMID:23678267

HD 101065, the Most Peculiar Star

Indian Academy of Sciences (India)

2016-01-27

Jan 27, 2016 ... In this paper we discuss the prospects for asteroseismology with spatial resolution and motivate studies of the most chemically peculiar roAp star HD 101065. We present the first results from a high-precision radial velocity (RV) study of HD 101065 based on data spanning four nights that were acquired ...

Development of a large-screen high-definition laser video projection system

Science.gov (United States)

Clynick, Tony J.

1991-08-01

A prototype laser video projector which uses electronic, optical, and mechanical means to project a television picture is described. With the primary goal of commercial viability, the price/performance ratio of the chosen means is critical. The fundamental requirement has been to achieve high brightness, high definition images of at least movie-theater size, at a cost comparable with other existing large-screen video projection technologies, while having the opportunity of developing and exploiting the unique properties of the laser projected image, such as its infinite depth-of-field. Two argon lasers are used in combination with a dye laser to achieve a range of colors which, despite not being identical to those of a CRT, prove to be subjectively acceptable. Acousto-optic modulation in combination with a rotary polygon scanner, digital video line stores, novel specialized electro-optics, and a galvanometric frame scanner form the basis of the projection technique achieving a 30 MHz video bandwidth, high- definition scan rates (1125/60 and 1250/50), high contrast ratio, and good optical efficiency. Auditorium projection of HDTV pictures wider than 20 meters are possible. Applications including 360 degree(s) projection and 3-D video provide further scope for exploitation of the HD laser video projector.

The Danish HD Registrya nationwide family registry of HD families in Denmark

DEFF Research Database (Denmark)

Gilling, M.; Budtz-Jorgensen, E.; Boonen, S. E.

2017-01-01

-8:100 000. 1451 individuals in the DHR had the size of the HTT CAG repeat determined of which 975 had 36 CAG repeats or more (mean ± SD: 43,5 ± 4,8). Two unrelated individuals were compound heterozygous for alleles ≥36 CAGs, and 60 individuals from 34 independent families carried an intermediate allele.......The Danish Huntington's Disease Registry (DHR) is a nationwide family registry comprising 14 245 individuals from 445 Huntington's disease (HD) families of which the largest family includes 845 individuals in 8 generations. 1136 DNA and/or blood samples and 18 fibroblast cultures are stored...... in a local biobank. The birthplace of the oldest HD carrier in each of the 261 families of Danish origin was unevenly distributed across Denmark with a high number of families in the middle part of the peninsula Jutland and in Copenhagen, the capital. The prevalence of HD in Denmark was calculated to be 5...

Spectroscopic studies of O-type binaries. IV. HD 165052 and Hd 167771

International Nuclear Information System (INIS)

Morrison, N.D.; Conti, P.S.

1978-01-01

HD 165052, O6.5 V, and HD 167771, 07.5 III ((f)), are double-lined binaries with periods of six and four days, respectively, and velocity semiamplitudes near 100 km s -1 . In our spectroscopic orbital analysis, we investigated the effect of correcting the measured radial velocities for pair blending. The derived velocity amplitudes are increased by roughly 7%, and hence the minimum masses increase by 20%--255. The raw data lead to minimum masses, m sin 3 i, between 2 and 3 mD/sub sun/. Since normal O stars are thought to have masses greater than 20 m/sub sun/, the orbits must be highly inclined to the line of sight. From the luminosities and effective temperatures we derived stellar radii. For HD 167771, the requirement that neither component over fill it Roche lobe implies that each has a mass in the neighborhood of 30m/sub sun/ or larger

NV-CMOS HD camera for day/night imaging

Science.gov (United States)

Vogelsong, T.; Tower, J.; Sudol, Thomas; Senko, T.; Chodelka, D.

2014-06-01

SRI International (SRI) has developed a new multi-purpose day/night video camera with low-light imaging performance comparable to an image intensifier, while offering the size, weight, ruggedness, and cost advantages enabled by the use of SRI's NV-CMOS HD digital image sensor chip. The digital video output is ideal for image enhancement, sharing with others through networking, video capture for data analysis, or fusion with thermal cameras. The camera provides Camera Link output with HD/WUXGA resolution of 1920 x 1200 pixels operating at 60 Hz. Windowing to smaller sizes enables operation at higher frame rates. High sensitivity is achieved through use of backside illumination, providing high Quantum Efficiency (QE) across the visible and near infrared (NIR) bands (peak QE camera, which operates from a single 5V supply. The NVCMOS HD camera provides a substantial reduction in size, weight, and power (SWaP) , ideal for SWaP-constrained day/night imaging platforms such as UAVs, ground vehicles, fixed mount surveillance, and may be reconfigured for mobile soldier operations such as night vision goggles and weapon sights. In addition the camera with the NV-CMOS HD imager is suitable for high performance digital cinematography/broadcast systems, biofluorescence/microscopy imaging, day/night security and surveillance, and other high-end applications which require HD video imaging with high sensitivity and wide dynamic range. The camera comes with an array of lens mounts including C-mount and F-mount. The latest test data from the NV-CMOS HD camera will be presented.

Weekly infusional high-dose fluorouracil (HD-FU), HD-FU plus folinic acid (HD-FU/FA), or HD-FU/FA plus biweekly cisplatin in advanced gastric cancer: randomized phase II trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie.

Science.gov (United States)

Lutz, Manfred P; Wilke, Hansjochen; Wagener, D J Theo; Vanhoefer, Udo; Jeziorski, Krzysztof; Hegewisch-Becker, Susanna; Balleisen, Leopold; Joossens, Eric; Jansen, Rob L; Debois, Muriel; Bethe, Ullrich; Praet, Michel; Wils, Jacques; Van Cutsem, Eric

2007-06-20

This multicentric, randomized, two-stage phase II trial evaluated three simplified weekly infusional regimens of fluorouracil (FU) or FU plus folinic acid (FA) and cisplatin (Cis) with the aim to select a regimen for future phase III trials. A total of 145 patients with advanced gastric cancer where randomly assigned to weekly FU 3,000 mg/m2/24 hours (HD-FU), FU 2,600 mg/m2/24 hours plus dl-FA 500 mg/m2 or l-FA 250 mg/m2 (HD-FU/FA), or FU 2000 mg/m2/24 hours plus FA plus biweekly Cis 50 mg/m2, each administered for 6 weeks with a 1-week rest. The primary end point was the response rate. Confirmed responses were observed in 6.1% (two of 33) of the eligible patients treated with HD-FU, in 25% (12 of 48, including one complete remission [CR]) with HD-FU/FA, and in 45.7% (21 of 46, including four CRs) with HD-FU/FA/Cis. The HD-FU arm was closed after stage 1 because the required minimum number of responses was not met. The median progression-free survival of all patients in the HD-FU, HD-FU/FA, and HD-FU/FA/Cis arm was 1.9, 4.0, and 6.1 months, respectively. The median overall survival was 7.1, 8.9, and 9.7 months, and the survival rate at 1 year was 24.3%, 30.3%, and 45.3%, respectively. Grade 4 toxicities were rare. The most relevant grade 3/4 toxicities were neutropenia in 1.9%, 5.4%, and 19.6%, and diarrhea in 2.7%, 1.9%, and 3.9% of the cycles in the HD-FU, HD-FU/FA, and HD-/FU/Cis arms, respectively. Weekly infusional FU/FA plus biweekly Cis is effective and safe in patients with gastric cancer.

Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography.

Science.gov (United States)

Ahlers, C; Simader, C; Geitzenauer, W; Stock, G; Stetson, P; Dastmalchi, S; Schmidt-Erfurth, U

2008-02-01

A limited number of scans compromise conventional optical coherence tomography (OCT) to track chorioretinal disease in its full extension. Failures in edge-detection algorithms falsify the results of retinal mapping even further. High-definition-OCT (HD-OCT) is based on raster scanning and was used to visualise the localisation and volume of intra- and sub-pigment-epithelial (RPE) changes in fibrovascular pigment epithelial detachments (fPED). Two different scanning patterns were evaluated. 22 eyes with fPED were imaged using a frequency-domain, high-speed prototype of the Cirrus HD-OCT. The axial resolution was 6 mum, and the scanning speed was 25 kA scans/s. Two different scanning patterns covering an area of 6 x 6 mm in the macular retina were compared. Three-dimensional topographic reconstructions and volume calculations were performed using MATLAB-based automatic segmentation software. Detailed information about layer-specific distribution of fluid accumulation and volumetric measurements can be obtained for retinal- and sub-RPE volumes. Both raster scans show a high correlation (p0.89) of measured values, that is PED volume/area, retinal volume and mean retinal thickness. Quality control of the automatic segmentation revealed reasonable results in over 90% of the examinations. Automatic segmentation allows for detailed quantitative and topographic analysis of the RPE and the overlying retina. In fPED, the 128 x 512 scanning-pattern shows mild advantages when compared with the 256 x 256 scan. Together with the ability for automatic segmentation, HD-OCT clearly improves the clinical monitoring of chorioretinal disease by adding relevant new parameters. HD-OCT is likely capable of enhancing the understanding of pathophysiology and benefits of treatment for current anti-CNV strategies in future.

Using the OOI Cabled Array HD Camera to Explore Geophysical and Oceanographic Problems at Axial Seamount

Science.gov (United States)

Crone, T. J.; Knuth, F.; Marburg, A.

2016-12-01

A broad array of Earth science problems can be investigated using high-definition video imagery from the seafloor, ranging from those that are geological and geophysical in nature, to those that are biological and water-column related. A high-definition video camera was installed as part of the Ocean Observatory Initiative's core instrument suite on the Cabled Array, a real-time fiber optic data and power system that stretches from the Oregon Coast to Axial Seamount on the Juan de Fuca Ridge. This camera runs a 14-minute pan-tilt-zoom routine 8 times per day, focusing on locations of scientific interest on and near the Mushroom vent in the ASHES hydrothermal field inside the Axial caldera. The system produces 13 GB of lossless HD video every 3 hours, and at the time of this writing it has generated 2100 recordings totaling 28.5 TB since it began streaming data into the OOI archive in August of 2015. Because of the large size of this dataset, downloading the entirety of the video for long timescale investigations is not practical. We are developing a set of user-side tools for downloading single frames and frame ranges from the OOI HD camera raw data archive to aid users interested in using these data for their research. We use these tools to download about one year's worth of partial frame sets to investigate several questions regarding the hydrothermal system at ASHES, including the variability of bacterial "floc" in the water-column, and changes in high temperature fluid fluxes using optical flow techniques. We show that while these user-side tools can facilitate rudimentary scientific investigations using the HD camera data, a server-side computing environment that allows users to explore this dataset without downloading any raw video will be required for more advanced investigations to flourish.

Low voltage operation of electro-absorption modulator promising for high-definition 3D imaging application using a three step asymmetric coupled quantum well structure

International Nuclear Information System (INIS)

Na, Byung Hoon; Ju, Gun Wu; Cho, Yong Chul; Lee, Yong Tak; Choi, Hee Ju; Jeon, Jin Myeong; Lee, Soo Kyung; Park, Yong Hwa; Park, Chang Young

2015-01-01

In this paper, we propose a transmission type electro-absorption modulator (EAM) operating at 850 nm having low operating voltage and high absorption change with low insertion loss using a novel three step asymmetric coupled quantum well (3 ACQW) structure which can be used as an optical image shutter for high-definition (HD) three dimensional (3D) imaging. Theoretical calculations show that the exciton red shift of 3 ACQW structure is more than two times larger than that of rectangular quantum well (RQW) structure while maintaining high absorption change. The EAM having coupled cavities with 3 ACQW structure shows a wide spectral bandwidth and high amplitude modulation at a bias voltage of only -8V, which is 41% lower in operating voltage than that of RQW, making the proposed EAM highly attractive as an optical image shutter for HD 3D imaging applications

High-definition transcranial direct-current stimulation of the right M1 further facilitates left M1 excitability during crossed facilitation.

Science.gov (United States)

Cabibel, Vincent; Muthalib, Makii; Teo, Wei-Peng; Perrey, Stephane

2018-04-01

The crossed-facilitation (CF) effect refers to when motor-evoked potentials (MEPs) evoked in the relaxed muscles of one arm are facilitated by contraction of the opposite arm. The aim of this study was to determine whether high-definition transcranial direct-current stimulation (HD-tDCS) applied to the right primary motor cortex (M1) controlling the left contracting arm [50% maximum voluntary isometric contraction (MVIC)] would further facilitate CF toward the relaxed right arm. Seventeen healthy right-handed subjects participated in an anodal and cathodal or sham HD-tDCS session of the right M1 (2 mA for 20 min) separated by at least 48 h. Single-pulse transcranial magnetic stimulation (TMS) was used to elicit MEPs and cortical silent periods (CSPs) from the left M1 at baseline and 10 min into and after right M1 HD-tDCS. At baseline, compared with resting, CF (i.e., right arm resting, left arm 50% MVIC) increased left M1 MEP amplitudes (+97%) and decreased CSPs (-11%). The main novel finding was that right M1 HD-tDCS further increased left M1 excitability (+28.3%) and inhibition (+21%) from baseline levels during CF of the left M1, with no difference between anodal and cathodal HD-tDCS sessions. No modulation of CSP or MEP was observed during sham HD-tDCS sessions. Our findings suggest that CF of the left M1 combined with right M1 anodal or cathodal HD-tDCS further facilitated interhemispheric interactions during CF from the right M1 (contracting left arm) toward the left M1 (relaxed right arm), with effects on both excitatory and inhibitory processing. NEW & NOTEWORTHY This study shows modulation of the nonstimulated left M1 by right M1 HD-tDCS combined with crossed facilitation, which was probably achieved through modulation of interhemispheric interactions.

Comparisons of amino acids, body constituents and antioxidative response between long-time HD and normal HD.

Science.gov (United States)

Torigoe, Akira; Sato, Emiko; Mori, Takefumi; Ieiri, Norio; Takahashi, Chika; Ishida, Yoko; Hotta, Osamu; Ito, Sadayoshi

2016-10-01

Introduction Oxidative stress is one of the main mediators of progression of chronic kidney diseases (CKD). Nuclear factor E2-related factor 2 (Nrf2) is the transcription factor of antioxidant and detoxifying enzymes and related proteins which play an important role in cellular defense. Long-time hemodialysis (HD) therapy (8 hours) has been considered to be more beneficial compared to normal HD therapy (4 hours). We investigated oxidative response related to Nrf2 in peripheral blood mononuclear cells (PBMCs) of long-time HD and normal HD patients. Methods Eight adult long-time HD therapy patients (44.5 ± 3.0 years) and 10 normal HD therapy patients (68.1 ± 2.7 years) were enrolled. PBMCs were isolated and processed for expression of Nrf2 and its related genes by qRT-PCR. Plasma indoxyl sulfate, amino acids, and body constituents were measured. Findings Plasma indoxyl sulfate was significantly low after long-time HD therapy compare to that of normal HD therapy. Although, skeletal muscle mass, lean body mass, mineral and protein were significantly decreased 2 months in normal HD patients, those in long-time HD patients were significantly increased after 2 months. Almost of amino acids were significantly decreased after HD therapy in both HD therapies. Plasma amino acids were significantly low in long-time HD patients compared to normal HD patients. In PBMCs, the expression of Nrf2 was significantly decreased and hemooxygenase-1 expression was significantly increased in long-time HD compared to normal HD. Conclusion These observations indicate the beneficial effects of in long-time HD in improving oxidative stress in patients. © 2016 International Society for Hemodialysis.

Clinically Effective Treatment of Fibromyalgia Pain With High-Definition Transcranial Direct Current Stimulation: Phase II Open-Label Dose Optimization.

Science.gov (United States)

Castillo-Saavedra, Laura; Gebodh, Nigel; Bikson, Marom; Diaz-Cruz, Camilo; Brandao, Rivail; Coutinho, Livia; Truong, Dennis; Datta, Abhishek; Shani-Hershkovich, Revital; Weiss, Michal; Laufer, Ilan; Reches, Amit; Peremen, Ziv; Geva, Amir; Parra, Lucas C; Fregni, Felipe

2016-01-01

Despite promising preliminary results in treating fibromyalgia (FM) pain, no neuromodulation technique has been adopted in clinical practice because of limited efficacy, low response rate, or poor tolerability. This phase II open-label trial aims to define a methodology for a clinically effective treatment of pain in FM by establishing treatment protocols and screening procedures to maximize efficacy and response rate. High-definition transcranial direct current stimulation (HD-tDCS) provides targeted subthreshold brain stimulation, combining tolerability with specificity. We aimed to establish the number of HD-tDCS sessions required to achieve a 50% FM pain reduction, and to characterize the biometrics of the response, including brain network activation pain scores of contact heat-evoked potentials. We report a clinically significant benefit of a 50% pain reduction in half (n = 7) of the patients (N = 14), with responders and nonresponders alike benefiting from a cumulative effect of treatment, reflected in significant pain reduction (P = .035) as well as improved quality of life (P = .001) over time. We also report an aggregate 6-week response rate of 50% of patients and estimate 15 as the median number of HD-tDCS sessions to reach clinically meaningful outcomes. The methodology for a pivotal FM neuromodulation clinical trial with individualized treatment is thus supported. Registered in Clinicaltrials.gov under registry number NCT01842009. In this article, an optimized protocol for the treatment of fibromyalgia pain with targeted subthreshold brain stimulation using high-definition transcranial direct current stimulation is outlined. Copyright © 2016 American Pain Society. Published by Elsevier Inc. All rights reserved.

Live Ultra-High Definition from the International Space Station

Science.gov (United States)

Grubbs, Rodney; George, Sandy

2017-01-01

The first ever live downlink of Ultra-High Definition (UHD) video from the International Space Station (ISS) was the highlight of a 'Super Session' at the National Association of Broadcasters (NAB) in April 2017. The Ultra-High Definition video downlink from the ISS all the way to the Las Vegas Convention Center required considerable planning, pushed the limits of conventional video distribution from a space-craft, and was the first use of High Efficiency Video Coding (HEVC) from a space-craft. The live event at NAB will serve as a pathfinder for more routine downlinks of UHD as well as use of HEVC for conventional HD downlinks to save bandwidth. HEVC may also enable live Virtual Reality video downlinks from the ISS. This paper will describe the overall work flow and routing of the UHD video, how audio was synchronized even though the video and audio were received many seconds apart from each other, and how the demonstration paves the way for not only more efficient video distribution from the ISS, but also serves as a pathfinder for more complex video distribution from deep space. The paper will also describe how a 'live' event was staged when the UHD coming from the ISS had a latency of 10+ seconds. Finally, the paper will discuss how NASA is leveraging commercial technologies for use on-orbit vs. creating technology as was required during the Apollo Moon Program and early space age.

Preliminary experience with 4K ultra-high definition endoscope: analysis of pros and cons in skull base surgery.

Science.gov (United States)

Rigante, M; La Rocca, G; Lauretti, L; D'Alessandris, G Q; Mangiola, A; Anile, C; Olivi, A; Paludetti, G

2017-06-01

During the last two decades endoscopic skull base surgery observed a continuous technical and technological development 3D endoscopy and ultra High Definition (HD) endoscopy have provided great advances in terms of visualisation and spatial resolution. Ultra-high definition (UHD) 4K systems, recently introduced in the clinical practice, will shape next steps forward especially in skull base surgery field. Patients were operated on through transnasal transsphenoidal endoscopic approaches performed using Olympus NBI 4K UHD endoscope with a 4 mm 0° Ultra Telescope, 300 W xenon lamp (CLV-S400) predisposed for narrow band imaging (NBI) technology connected through a camera head to a high-quality control unit (OTV-S400 - VISERA 4K UHD) (Olympus Corporation, Tokyo, Japan). Two screens are used, one 31" Monitor - (LMD-X310S) and one main ultra-HD 55" screen optimised for UHD image reproduction (LMD-X550S). In selected cases, we used a navigation system (Stealthstation S7, Medtronic, Minneapolis, MN, US). We evaluated 22 pituitary adenomas (86.3% macroadenomas; 13.7% microadenomas). 50% were not functional (NF), 22.8% GH, 18.2% ACTH, 9% PRL-secreting. Three of 22 were recurrences. In 91% of cases we achieved total removal, while in 9% near total resection. A mean follow-up of 187 days and average length of hospitalisation was 3.09 ± 0.61 days. Surgical duration was 128.18± 30.74 minutes. We experienced only 1 case of intraoperative low flow fistula with no further complications. None of the cases required any post- or intraoperative blood transfusion. The visualisation and high resolution of the operative field provided a very detailed view of all anatomical structures and pathologies allowing an improvement in safety and efficacy of the surgical procedure. The operative time was similar to the standard 2D HD and 3D procedures and the physical strain was also comparable to others in terms of ergonomics and weight. © Copyright by Società Italiana di Otorinolaringologia

Polarized proton and deuteron solid HD targets

International Nuclear Information System (INIS)

Honig, A.

1977-01-01

A decade has now elapsed since HD was proposed as a polarized proton and deuteron target with exceptionally desirable properties. These include a very high free proton proportion, independently polarizable proton and deuteron systems, and a ''frozen-spin'' mode of operation which allows separation of the functions of production and utilization of the highly polarized target. A discussion is given of what can be expected of the polarized HD system right now, without further research. The basic features of solid HD pertinent to its use as a ''frozen-spin'' target are outlined, then a summary is given of the particular experimental results which support the contention that the target will perform successfully, and finally, some feasible operating modes and the expected performances from them are presented

Measurement-based Monte Carlo simulation of high definition dose evaluation for nasopharyngeal cancer patients treated by using intensity modulated radiation therapy

International Nuclear Information System (INIS)

Yeh, C.Y.; Tung, C.J.; Lee, C.C.; Lin, M.H.; Chao, T.C.

2014-01-01

Measurement-based Monte Carlo (MBMC) simulation using a high definition (HD) phantom was used to evaluate the dose distribution in nasopharyngeal cancer (NPC) patients treated with intensity modulated radiation therapy (IMRT). Around nasopharyngeal cavity, there exists many small volume organs-at-risk (OARs) such as the optic nerves, auditory nerves, cochlea, and semicircular canal which necessitate the use of a high definition phantom for accurate and correct dose evaluation. The aim of this research was to study the advantages of using an HD phantom for MBMC simulation in NPC patients treated with IMRT. The MBMC simulation in this study was based on the IMRT treatment plan of three NPC patients generated by the anisotropic analytical algorithm (AAA) of the Eclipse treatment planning system (Varian Medical Systems, Palo Alto, CA, USA) using a calculation grid of 2 mm 2 . The NPC tumor was treated to a cumulative dose of 7000 cGy in 35 fractions using the shrinking-field sequential IMRT (SIMRT) method. The BEAMnrc MC Code was used to simulate a Varian EX21 linear accelerator treatment head. The HD phantom contained 0.5 × 0.5 × 1 mm 3 voxels for the nasopharyngeal area and 0.5 × 0.5 × 3 mm 3 for the rest of the head area. An efficiency map was obtained for the amorphous silicon aS1000 electronic portal imaging device (EPID) to adjust the weighting of each particle in the phase-space file for each IMRT beam. Our analysis revealed that small volume organs such as the eighth cranial nerve, semicircular canal, cochlea and external auditory canal showed an absolute dose difference of ≥200 cGy, while the dose difference for larger organs such as the parotid glands and tumor was negligible for the MBMC simulation using the HD phantom. The HD phantom was found to be suitable for Monte Carlo dose volume analysis of small volume organs. - Highlights: • HD dose evaluation for IMRT of NPC patients have been verified by the MC method. • MC results shows

Processor core for real time background identification of HD video based on OpenCV Gaussian mixture model algorithm

Science.gov (United States)

Genovese, Mariangela; Napoli, Ettore

2013-05-01

The identification of moving objects is a fundamental step in computer vision processing chains. The development of low cost and lightweight smart cameras steadily increases the request of efficient and high performance circuits able to process high definition video in real time. The paper proposes two processor cores aimed to perform the real time background identification on High Definition (HD, 1920 1080 pixel) video streams. The implemented algorithm is the OpenCV version of the Gaussian Mixture Model (GMM), an high performance probabilistic algorithm for the segmentation of the background that is however computationally intensive and impossible to implement on general purpose CPU with the constraint of real time processing. In the proposed paper, the equations of the OpenCV GMM algorithm are optimized in such a way that a lightweight and low power implementation of the algorithm is obtained. The reported performances are also the result of the use of state of the art truncated binary multipliers and ROM compression techniques for the implementation of the non-linear functions. The first circuit has commercial FPGA devices as a target and provides speed and logic resource occupation that overcome previously proposed implementations. The second circuit is oriented to an ASIC (UMC-90nm) standard cell implementation. Both implementations are able to process more than 60 frames per second in 1080p format, a frame rate compatible with HD television.

High-definition hematoxylin and eosin staining in a transition to digital pathology

Directory of Open Access Journals (Sweden)

Jamie D Martina

2011-01-01

Full Text Available Introduction: A lot of attention has been generated in recent years by digital pathology and telepathology. Multiple reasons for and barriers to effective adoption are discussed in the current literature. Digital slides are the most promising medium at this time. The goal of our study was to evaluate whether the change in the methodology, particularly utilizing the so-called high-definition hematoxylin and eosin (H and E slides, enhanced the quality of the final digital slide, and whether pathologists who tested the results perceived this as a difference in quality. Methods: The study was a blinded comparison of digital slides prepared using two methods: standard H&E batch staining and automated individual "high definition" HD HE staining. Four pathologists have compared 80 cases stained with each method. Results: The results discussed in this study show potential promise that the utilization of protocol(s adapted for tissue and for imaging might be preferable for digital pathology in at least some of the pathology subspecialties. In particular, the protocol evaluated here was capable of turning out digital slides that had more contrast and detail, and therefore were perceived to provide enhanced diagnostically significant information for the pathologist.

HD 66051, an eclipsing binary hosting a highly peculiar, HgMn-related star.

Science.gov (United States)

Niemczura, Ewa; Hümmerich, Stefan; Castelli, Fiorella; Paunzen, Ernst; Bernhard, Klaus; Hambsch, Franz-Josef; Hełminiak, Krzysztof

2017-07-19

HD 66051 is an eclipsing system with an orbital period of about 4.75 d that exhibits out-of-eclipse variability with the same period. New multicolour photometric observations confirm the longevity of the secondary variations, which we interpret as a signature of surface inhomogeneities on one of the components. Using archival and newly acquired high-resolution spectra, we have performed a detailed abundance analysis. The primary component is a slowly rotating late B-type star (T eff  = 12500 ± 200 K; log g = 4.0, v sin i = 27 ± 2 km s -1 ) with a highly peculiar composition reminiscent of the singular HgMn-related star HD 65949, which seems to be its closest analogue. Some light elements as He, C, Mg, Al are depleted, while Si and P are enhanced. Except for Ni, all the iron-group elements, as well as most of the heavy elements, and in particular the REE elements, are overabundant. The secondary component was estimated to be a slowly rotating A-type star (T eff  ~ 8000 K; log g = 4.0, v sin i ~ 18 km s -1 ). The unique configuration of HD 66051 opens up intriguing possibilities for future research, which might eventually and significantly contribute to the understanding of such diverse phenomena as atmospheric structure, mass transfer, magnetic fields, photometric variability and the origin of chemical anomalies observed in HgMn stars and related objects.

HD271791: dynamical versus binary-supernova ejection scenario

Science.gov (United States)

Gvaramadze, V. V.

2009-05-01

The atmosphere of the extremely high-velocity (530-920kms-1) early B-type star HD271791 is enriched in α-process elements, which suggests that this star is a former secondary component of a massive tight binary system and that its surface was polluted by the nucleosynthetic products after the primary star exploded in a supernova. It was proposed that the (asymmetric) supernova explosion unbind the system and that the secondary star (HD271791) was released at its orbital velocity in the direction of Galactic rotation. In this Letter, we show that to explain the Galactic rest-frame velocity of HD271791 within the framework of the binary-supernova scenario, the stellar remnant of the supernova explosion (a =750-1200kms-1. We therefore consider the binary-supernova scenario as highly unlikely and instead propose that HD271791 attained its peculiar velocity in the course of a strong dynamical three- or four-body encounter in the dense core of the parent star cluster. Our proposal implies that by the moment of encounter HD271791 was a member of a massive post-supernova binary.

Usefulness and capability of three-dimensional, full high-definition movies for surgical education.

Science.gov (United States)

Takano, M; Kasahara, K; Sugahara, K; Watanabe, A; Yoshida, S; Shibahara, T

2017-12-01

Because of changing surgical procedures in the fields of oral and maxillofacial surgery, new methods for surgical education are needed and could include recent advances in digital technology. Many doctors have attempted to use digital technology as educational tools for surgical training, and movies have played an important role in these attempts. We have been using a 3D full high-definition (full-HD) camcorder to record movies of intra-oral surgeries. The subjects were medical students and doctors receiving surgical training who did not have actual surgical experience ( n  = 67). Participants watched an 8-min, 2D movie of orthognathic surgery and subsequently watched the 3D version. After watching the 3D movie, participants were asked to complete a questionnaire. A lot of participants (84%) felt a 3D movie excellent or good and answered that the advantages of a 3D movie were their appearance of solidity or realism. Almost all participants (99%) answered that 3D movies were quite useful or useful for medical practice. Three-dimensional full-HD movies have the potential to improve the quality of medical education and clinical practice in oral and maxillofacial surgery.

Fundamental parameters of massive stars in multiple systems: The cases of HD 17505A and HD 206267A

Science.gov (United States)

Raucq, F.; Rauw, G.; Mahy, L.; Simón-Díaz, S.

2018-06-01

Context. Many massive stars are part of binary or higher multiplicity systems. The present work focusses on two higher multiplicity systems: HD 17505A and HD 206267A. Aims: Determining the fundamental parameters of the components of the inner binary of these systems is mandatory to quantify the impact of binary or triple interactions on their evolution. Methods: We analysed high-resolution optical spectra to determine new orbital solutions of the inner binary systems. After subtracting the spectrum of the tertiary component, a spectral disentangling code was applied to reconstruct the individual spectra of the primary and secondary. We then analysed these spectra with the non-LTE model atmosphere code CMFGEN to establish the stellar parameters and the CNO abundances of these stars. Results: The inner binaries of these systems have eccentric orbits with e 0.13 despite their relatively short orbital periods of 8.6 and 3.7 days for HD 17505Aa and HD 206267Aa, respectively. Slight modifications of the CNO abundances are found in both components of each system. The components of HD 17505Aa are both well inside their Roche lobe, whilst the primary of HD 206267Aa nearly fills its Roche lobe around periastron passage. Whilst the rotation of the primary of HD 206267Aa is in pseudo-synchronization with the orbital motion, the secondary displays a rotation rate that is higher. Conclusions: The CNO abundances and properties of HD 17505Aa can be explained by single star evolutionary models accounting for the effects of rotation, suggesting that this system has not yet experienced binary interaction. The properties of HD 206267Aa suggest that some intermittent binary interaction might have taken place during periastron passages, but is apparently not operating anymore. Based on observations collected with the TIGRE telescope (La Luz, Mexico), the 1.93 m telescope at Observatoire de Haute Provence (France), the Nordic Optical Telescope at the Observatorio del Roque de los

Actinic keratosis in the en-face and slice imaging mode of high-definition optical coherence tomography and comparison with histology.

Science.gov (United States)

Maier, T; Braun-Falco, M; Laubender, R P; Ruzicka, T; Berking, C

2013-01-01

Optical coherence tomography (OCT) allows real-time, in vivo examination of nonmelanoma skin cancer. An innovative high-definition (HD)-OCT with a horizontal (en-face) and vertical (slice) imaging mode offers additional information in the diagnosis of actinic keratosis (AK) and may potentially replace invasive diagnostic biopsies.  To define the characteristic morphological features of AK by using HD-OCT in the two imaging modes compared with histopathology as gold standard.  In total, 20 AKs were examined by HD-OCT in the en-face and slice imaging modes and characteristic features were described and evaluated in comparison with the histopathological findings. Furthermore, the HD-OCT images of a subgroup of AKs were compared with those of the clinically normal adjacent skin.  The preoperative in vivo diagnostics showed the following features in the en-face imaging mode of HD-OCT: disruption of stratum corneum, architectural disarray, cellular/nuclear polymorphism in the stratum granulosum/stratum spinosum, and bright irregular bundles in the superficial dermis. In the vertical slice imaging mode the following characteristics were found: irregular entrance signal, destruction of layering, white streaks and dots, and grey areas. In contrast, the clinically healthy adjacent skin showed mainly a regular epidermal 'honeycomb' pattern in the en-face mode and distinct layering of the skin in the slice mode.  HD-OCT with both the en-face and slice imaging modes offers additional information in the diagnosis of AK compared with conventional OCT and might enhance the possibility of the noninvasive diagnosis of AK prior to treatment procedures and possibly in the monitoring of noninvasive treatment strategies. © 2012 The Authors. BJD © 2012 British Association of Dermatologists.

High Resolution Optical Spectroscopy of an Intriguing High-Latitude B-Type Star HD119608

Science.gov (United States)

Şahin, T.

2018-01-01

We present an LTE analysis of high resolution echelle optical spectra obtained with the 3.9-m Anglo-Australian Telescope (AAT) and the UCLES spectrograph for a B1Ib high galactic latitude supergiant HD119608. A fresh determination of the atmospheric parameters using line-blanketed LTE model atmospheres and spectral synthesis provided T eff = 23 300 ± 1000 K, log g = 3.0 ± 0.3, and the microturbulent velocity ξ = 6.0 ± 1.0 kms-1 and [Fe/H] = 0.16. The rotational velocity of the star was derived fromC, O, N, Al, and Fe lines as v sin i = 55.8 ± 1.3 kms-1. Elemental abundances were obtained for 10 different species. He, Al, and P abundances of the star were determined for the first time. In the spectra, hot post-AGB status as well as the Pop I characteristics of the star were examined. The approximately solar carbon and oxygen abundances, along with mild excess in helium and nitrogen abundances do not stipulate a CNO processed surface composition, hence a hot post-AGB status. The LTE abundances analysis also indicates solar sulphur and moderately enriched magnesium abundances. The average abundances of B dwarfs of well studied OB associations and Population I stars show a striking resemblance to abundances obtained for HD119608 in this study. This may imply a runaway status for the star.

Precision of high definition spectral-domain optical coherence tomography for measuring central corneal thickness.

Science.gov (United States)

Correa-Pérez, María E; López-Miguel, Alberto; Miranda-Anta, Silvia; Iglesias-Cortiñas, Darío; Alió, Jorge L; Maldonado, Miguel J

2012-04-06

This study was intended to assess the reliability of central corneal thickness (CCT) measurements using Cirrus high-definition optical coherence tomography (HD-OCT) in healthy subjects and its accuracy compared with ultrasonic pachymetry. Seventy-seven consecutive subjects were recruited for evaluating repeatability, and agreement between two examiners. To analyze repeatability, one examiner measured 77 eyes four times in succession. To study agreement between two observers, a second independently trained examiner obtained another CCT measurement. We also measured eyes in a subgroup of 20 patients using standard ultrasonic pachymetry. Within-subject standard deviation (S(w)), coefficient of variation (CV), limits of agreement (LoA), and intraclass correlation coefficient (ICC) data were obtained. For repeatability, the S(w) and precision (1.96 × S(w)) were 4.86 and 9.52 μm, respectively. Intraobserver CV was 0.89% and the ICC was 0.98 (95% confidence interval [CI], 0.97-0.99). For agreement between two examiners, the S(w) and precision were 7.58 and 14.85 μm, respectively; the CV was 1.40%. The mean difference between observers was -0.13 μm (95% CI, -1.85 to 1.58; P = 0.87). The width of the LoA was 29.64 μm. Median difference between Cirrus HD-OCT and ultrasound CCT measurements was -4.5 μm (interquartile range, -7.0-0.0; P = 0.04). Cirrus HD-OCT provides repeatable CCT measurements, good agreement between two independently trained examiners, and its systematic bias compared to ultrasonic pachymetry is clinically negligible. Therefore, research laboratories and eye clinics using Cirrus HD-OCT as a diagnostic imaging method, can also benefit from a reliable noncontact pachymeter when counseling patients with glaucoma and those undergoing corneal and refractive surgeries.

Dosimetry during mango irradiation using Gafchromic HD-810 film

International Nuclear Information System (INIS)

Sharma, S. D.; Chilkulwar, R. H.; Kumar, R.

2009-01-01

The dosimetric characteristics of Gafchromic HD-810 film were evaluated for its possible use as a high-dose dosemeter for routine dosimetry during mango irradiation. The film dosemeter sample of size 2 x 2 cm 2 was used throughout the course of this work. The irradiation of the film dosemeter for characterisation and calibration purposes was carried out in a gamma irradiator. The dose-response of the Gafchromic HD-810 film dosemeter at 550 nm was found to be linear in the dose range 50-1000 Gy, which indicates the feasibility of using this film for dosimetry up to 1000 Gy. The mean inter-dosemeter variation was within 2%, which gives better dose-response consistency of the HD-810 film. The radiation absorbed dose measured by the Gafchromic HD-810 film dosemeter during mango irradiation was compared with that measured by a standard Ceric-cerous dosemeter. This study establishes the Gafchromic HD-810 film as a convenient and technically suitable dosemeter for high-dose dosimetry up to 1.0 kGy during mango irradiation. (authors)

Behavior of Abundances in Chemically Peculiar Dwarf and Subgiant A-Type Stars: HD 23193 and HD 170920

Science.gov (United States)

Kılıçoğlu, Tolgahan; Çalışkan, Şeyma; Ünal, Kübraözge

2018-01-01

To understand the origin of the abundance peculiarities of non-magnetic A-type stars, we present the first detailed chemical abundance analysis of a metallic line star HD 23193 (A2m) and an A-type subgiant HD 170920 (A5), which could have been a HgMn star on the main sequence. Our analysis is based on medium (R ∼ 14,000) and high (R ∼ 40,000) resolution spectroscopic data of the stars. The abundances of 18 elements are derived: C, O, Na, Mg, Al, Si, S, Ca, Sc, Ti, Cr, Mn, Fe, Ni, Zn, Sr, Y, and Ba. The masses of HD 23193 and HD 170920 are estimated from evolutionary tracks as 2.3 ± 0.1 M ⊙ and 2.9 ± 0.1 M ⊙. The ages are found to be 635 ± 33 Myr for HD 23193 and 480 ± 50 Myr for HD 170920 using isochrones. The abundance pattern of HD 23193 shows deviations from solar values in the iron-peak elements and indicates remarkable overabundances of Sr (1.16), Y (1.03), and Ba (1.24) with respect to the solar abundances. We compare the derived abundances of this moderately rotating (v\\sin i =37.5 km s‑1) Am star to the theoretical chemical evolution models including rotational mixing. The theoretically predicted abundances resemble our derived abundance pattern, except for a few elements (Si and Cr). For HD 170920, we find nearly solar abundances, except for C (‑0.43), S (0.16), Ti (0.15), Ni (0.16), Zn (0.41), Y (0.57), and Ba (0.97). Its low rotational velocity (v\\sin i=14.5 km s‑1), reduced carbon abundance, and enhanced heavy element abundances suggest that the star is most likely an evolved HgMn star. Based on observations made at the TÜBITAK National Observatory (Program ID 14BRTT150–671), and the Ankara University Observatory, Turkey.

ROBUST MOTION SEGMENTATION FOR HIGH DEFINITION VIDEO SEQUENCES USING A FAST MULTI-RESOLUTION MOTION ESTIMATION BASED ON SPATIO-TEMPORAL TUBES

OpenAIRE

Brouard , Olivier; Delannay , Fabrice; Ricordel , Vincent; Barba , Dominique

2007-01-01

4 pages; International audience; Motion segmentation methods are effective for tracking video objects. However, objects segmentation methods based on motion need to know the global motion of the video in order to back-compensate it before computing the segmentation. In this paper, we propose a method which estimates the global motion of a High Definition (HD) video shot and then segments it using the remaining motion information. First, we develop a fast method for multi-resolution motion est...

Working memory capacity differentially influences responses to tDCS and HD-tDCS in a retro-cue task.

Science.gov (United States)

Gözenman, Filiz; Berryhill, Marian E

2016-08-26

There is growing interest in non-invasive brain stimulation techniques. A drawback is that the relationship between stimulation and cognitive outcomes for various tasks are unknown. Transcranial direct current stimulation (tDCS) provides diffuse current spread, whereas high-definition tDCS (HD-tDCS) provides more targeted current. The direction of behavioral effects after tDCS can be difficult to predict in cognitive realms such as attention and working memory (WM). Previously, we showed that in low and high WM capacity groups tDCS modulates performance in nearly equal and opposite directions on a change detection task, with improvement for the high capacity participants alone. Here, we used the retro-cue paradigm to test attentional shifting among items in WM to investigate whether WM capacity (WMC) predicted different behavioral consequences during anodal tDCS or HD-tDCS to posterior parietal cortex (PPC). In two experiments, with 24 participants each, we used different stimulus categories (colored circles, letters) and stimulation sites (right, left PPC). The results showed a significant (Experiment 1) or trending (Experiment 2) WMC x stimulation interaction. Compared to tDCS, after HD-tDCS the retro-cueing benefit was significantly greater for the low WMC group but numerically worse for the high WMC group. These data highlight the importance of considering group differences when using non-invasive neurostimulation techniques. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

THE TRENDS HIGH-CONTRAST IMAGING SURVEY. III. A FAINT WHITE DWARF COMPANION ORBITING HD 114174

International Nuclear Information System (INIS)

Crepp, Justin R.; Johnson, John Asher; Howard, Andrew W.; Marcy, Geoffrey W.; Gianninas, Alexandros; Kilic, Mukremin; Wright, Jason T.

2013-01-01

The nearby Sun-like star HD 114174 exhibits a strong and persistent Doppler acceleration indicating the presence of an unseen distant companion. We have acquired high-contrast imaging observations of this star using NIRC2 at Keck and report the direct detection of the body responsible for causing the ''trend''. HD 114174 B has a projected separation of 692 ± 9 mas (18.1 AU) and is 10.75 ± 0.12 mag (contrast of 5 × 10 –5 ) fainter than its host in the K-band, requiring aggressive point-spread function subtraction to identify. Our astrometric time baseline of 1.4 yr demonstrates physical association through common proper motion. We find that the companion has absolute magnitude, M J = 13.97 ± 0.11, and colors, J – K = 0.12 ± 0.16 mag. These characteristics are consistent with an ≈T3 dwarf, initially leading us to believe that HD 114174 B was a substellar object. However, a dynamical analysis that combines radial velocity measurements with available imaging data indicates a minimum mass of 0.260 ± 0.010 M ☉ . We conclude that HD 114174 B must be a white dwarf. Assuming a hydrogen-rich composition, atmospheric and evolutionary model fits yield an effective temperature T eff = 8200 ± 4000 K, surface gravity log g = 8.90 ± 0.02, and cooling age of t c ≈ 3.4 Gyr, which is consistent with the 4.7 +2.3 -2.6 Gyr host star isochronal age estimate. HD 114174 B is a benchmark object located only 26.14 ± 0.37 pc from the Sun. It may be studied at a level of detail comparable to Sirius and Procyon, and used to understand the link between the mass of white dwarf remnants with that of their progenitors

THE TRENDS HIGH-CONTRAST IMAGING SURVEY. III. A FAINT WHITE DWARF COMPANION ORBITING HD 114174

Energy Technology Data Exchange (ETDEWEB)

Crepp, Justin R. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Johnson, John Asher [Department of Planetary Science, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125 (United States); Howard, Andrew W. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Marcy, Geoffrey W. [Department of Astronomy, University of California, Berkeley, CA 94720 (United States); Gianninas, Alexandros; Kilic, Mukremin [Department of Physics and Astronomy, University of Oklahoma, Norman, OK 73019 (United States); Wright, Jason T., E-mail: jcrepp@nd.edu [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States)

2013-09-01

The nearby Sun-like star HD 114174 exhibits a strong and persistent Doppler acceleration indicating the presence of an unseen distant companion. We have acquired high-contrast imaging observations of this star using NIRC2 at Keck and report the direct detection of the body responsible for causing the ''trend''. HD 114174 B has a projected separation of 692 {+-} 9 mas (18.1 AU) and is 10.75 {+-} 0.12 mag (contrast of 5 Multiplication-Sign 10{sup -5}) fainter than its host in the K-band, requiring aggressive point-spread function subtraction to identify. Our astrometric time baseline of 1.4 yr demonstrates physical association through common proper motion. We find that the companion has absolute magnitude, M{sub J} = 13.97 {+-} 0.11, and colors, J - K = 0.12 {+-} 0.16 mag. These characteristics are consistent with an Almost-Equal-To T3 dwarf, initially leading us to believe that HD 114174 B was a substellar object. However, a dynamical analysis that combines radial velocity measurements with available imaging data indicates a minimum mass of 0.260 {+-} 0.010 M{sub Sun }. We conclude that HD 114174 B must be a white dwarf. Assuming a hydrogen-rich composition, atmospheric and evolutionary model fits yield an effective temperature T{sub eff} = 8200 {+-} 4000 K, surface gravity log g = 8.90 {+-} 0.02, and cooling age of t{sub c} Almost-Equal-To 3.4 Gyr, which is consistent with the 4.7{sup +2.3}{sub -2.6} Gyr host star isochronal age estimate. HD 114174 B is a benchmark object located only 26.14 {+-} 0.37 pc from the Sun. It may be studied at a level of detail comparable to Sirius and Procyon, and used to understand the link between the mass of white dwarf remnants with that of their progenitors.

Simulating pad-electrodes with high-definition arrays in transcranial electric stimulation

Science.gov (United States)

Kempe, René; Huang, Yu; Parra, Lucas C.

2014-04-01

Objective. Research studies on transcranial electric stimulation, including direct current, often use a computational model to provide guidance on the placing of sponge-electrode pads. However, the expertise and computational resources needed for finite element modeling (FEM) make modeling impractical in a clinical setting. Our objective is to make the exploration of different electrode configurations accessible to practitioners. We provide an efficient tool to estimate current distributions for arbitrary pad configurations while obviating the need for complex simulation software. Approach. To efficiently estimate current distributions for arbitrary pad configurations we propose to simulate pads with an array of high-definition (HD) electrodes and use an efficient linear superposition to then quickly evaluate different electrode configurations. Main results. Numerical results on ten different pad configurations on a normal individual show that electric field intensity simulated with the sampled array deviates from the solutions with pads by only 5% and the locations of peak magnitude fields have a 94% overlap when using a dense array of 336 electrodes. Significance. Computationally intensive FEM modeling of the HD array needs to be performed only once, perhaps on a set of standard heads that can be made available to multiple users. The present results confirm that by using these models one can now quickly and accurately explore and select pad-electrode montages to match a particular clinical need.

Pro Tools HD

CERN Document Server

Camou, Edouard

2013-01-01

An easy-to-follow guide for using Pro Tools HD 11 effectively.This book is ideal for anyone who already uses ProTools and wants to learn more, or is new to Pro Tools HD and wants to use it effectively in their own audio workstations.

High-Definition 3D Stereoscopic Microscope Display System for Biomedical Applications

Directory of Open Access Journals (Sweden)

Yoo Kwan-Hee

2010-01-01

Full Text Available Biomedical research has been performed by using advanced information techniques, and micro-high-quality stereo images have been used by researchers and/or doctors for various aims in biomedical research and surgery. To visualize the stereo images, many related devices have been developed. However, the devices are difficult to learn for junior doctors and demanding to supervise for experienced surgeons. In this paper, we describe the development of a high-definition (HD three-dimensional (3D stereoscopic imaging display system for operating a microscope or experimenting on animals. The system consists of a stereoscopic camera part, image processing device for stereoscopic video recording, and stereoscopic display. In order to reduce eyestrain and viewer fatigue, we use a preexisting stereo microscope structure and polarized-light stereoscopic display method that does not reduce the quality of the stereo images. The developed system can overcome the discomfort of the eye piece and eyestrain caused by use over a long period of time.

3-D dosimetric evaluation of 2.5 mm HD120 multileaf system for intensity modulated stereotactic radiosurgery using optical CT based polymer gel dosimetry

International Nuclear Information System (INIS)

Wuu, C-S; Kessel, Jack; Xu, Y

2009-01-01

A Trilogy TX equipped with a 2.5 mm HD120 multileaf collimator system is available for the treatment of radiosurgery and IMRT. In this study, we evaluated the 3-D dosimetric impact of leaf width on an IMRT radiosurgery plan by comparing the target coverage and the dose gradient around the target, produced from both a 2.5 mm HD120 high-definition MLC system and a 5mm-leaf-width millennium 120 MLC system, using an optical CT based polymer gel dosimetry system. The 2.5 mm MLC improves target conformity and surrounding tissue sparing when compared to that of 5 mm MLC.

Design of a Binocular Pupil and Gaze Point Detection System Utilizing High Definition Images

Directory of Open Access Journals (Sweden)

Yilmaz Durna

2017-05-01

Full Text Available This study proposes a novel binocular pupil and gaze detection system utilizing a remote full high definition (full HD camera and employing LabVIEW. LabVIEW is inherently parallel and has fewer time-consuming algorithms. Many eye tracker applications are monocular and use low resolution cameras due to real-time image processing difficulties. We utilized the computer’s direct access memory channel for rapid data transmission and processed full HD images with LabVIEW. Full HD images make easier determinations of center coordinates/sizes of pupil and corneal reflection. We modified the camera so that the camera sensor passed only infrared (IR images. Glints were taken as reference points for region of interest (ROI area selection of the eye region in the face image. A morphologic filter was applied for erosion of noise, and a weighted average technique was used for center detection. To test system accuracy with 11 participants, we produced a visual stimulus set up to analyze each eye’s movement. Nonlinear mapping function was utilized for gaze estimation. Pupil size, pupil position, glint position and gaze point coordinates were obtained with free natural head movements in our system. This system also works at 2046 × 1086 resolution at 40 frames per second. It is assumed that 280 frames per second for 640 × 480 pixel images is the case. Experimental results show that the average gaze detection error for 11 participants was 0.76° for the left eye, 0.89° for right eye and 0.83° for the mean of two eyes.

THE MASS OF HD 38529c FROM HUBBLE SPACE TELESCOPE ASTROMETRY AND HIGH-PRECISION RADIAL VELOCITIES

International Nuclear Information System (INIS)

Benedict, G. Fritz; McArthur, Barbara E.; Bean, Jacob L.; Barnes, Rory; Harrison, Thomas E.; Hatzes, Artie; Martioli, Eder; Nelan, Edmund P.

2010-01-01

Hubble Space Telescope Fine Guidance Sensor astrometric observations of the G4 IV star HD 38529 are combined with the results of the analysis of extensive ground-based radial velocity (RV) data to determine the mass of the outermost of two previously known companions. Our new RVs obtained with the Hobby-Eberly Telescope and velocities from the Carnegie-California group now span over 11 yr. With these data we obtain improved RV orbital elements for both the inner companion, HD 38529b, and the outer companion, HD 38529c. We identify a rotational period of HD 38529 (P rot = 31.65 ± 0fd17) with Fine Guidance Sensor photometry. The inferred star spot fraction is consistent with the remaining scatter in velocities being caused by spot-related stellar activity. We then model the combined astrometric and RV measurements to obtain the parallax, proper motion, perturbation period, perturbation inclination, and perturbation size due to HD 38529c. For HD 38529c we find P = 2136.1 ± 0.3 d, perturbation semimajor axis α = 1.05 ± 0.06 mas, and inclination i = 48. 0 3 ± 3. 0 7. Assuming a primary mass M * = 1.48 M sun , we obtain a companion mass M c = 17.6 +1.5 -1.2 M Jup , 3σ above a 13 M Jup deuterium burning, brown dwarf lower limit. Dynamical simulations incorporating this accurate mass for HD 38529c indicate that a near-Saturn mass planet could exist between the two known companions. We find weak evidence of an additional low amplitude signal that can be modeled as a planetary-mass (∼0.17 M Jup ) companion at P ∼194 days. Including this component in our modeling lowers the error of the mass determined for HD 38529c. Additional observations (RVs and/or Gaia astrometry) are required to validate an interpretation of HD 38529d as a planetary-mass companion. If confirmed, the resulting HD 38529 planetary system may be an example of a 'Packed Planetary System'.

Surgeon point-of-view recording: Using a high-definition head-mounted video camera in the operating room

Directory of Open Access Journals (Sweden)

Akshay Gopinathan Nair

2015-01-01

Full Text Available Objective: To study the utility of a commercially available small, portable ultra-high definition (HD camera (GoPro Hero 4 for intraoperative recording. Methods: A head mount was used to fix the camera on the operating surgeon′s head. Due care was taken to protect the patient′s identity. The recorded video was subsequently edited and used as a teaching tool. This retrospective, noncomparative study was conducted at three tertiary eye care centers. The surgeries recorded were ptosis correction, ectropion correction, dacryocystorhinostomy, angular dermoid excision, enucleation, blepharoplasty and lid tear repair surgery (one each. The recorded videos were reviewed, edited, and checked for clarity, resolution, and reproducibility. Results: The recorded videos were found to be high quality, which allowed for zooming and visualization of the surgical anatomy clearly. Minimal distortion is a drawback that can be effectively addressed during postproduction. The camera, owing to its lightweight and small size, can be mounted on the surgeon′s head, thus offering a unique surgeon point-of-view. In our experience, the results were of good quality and reproducible. Conclusions: A head-mounted ultra-HD video recording system is a cheap, high quality, and unobtrusive technique to record surgery and can be a useful teaching tool in external facial and ophthalmic plastic surgery.

Surgeon point-of-view recording: Using a high-definition head-mounted video camera in the operating room.

Science.gov (United States)

Nair, Akshay Gopinathan; Kamal, Saurabh; Dave, Tarjani Vivek; Mishra, Kapil; Reddy, Harsha S; Della Rocca, David; Della Rocca, Robert C; Andron, Aleza; Jain, Vandana

2015-10-01

To study the utility of a commercially available small, portable ultra-high definition (HD) camera (GoPro Hero 4) for intraoperative recording. A head mount was used to fix the camera on the operating surgeon's head. Due care was taken to protect the patient's identity. The recorded video was subsequently edited and used as a teaching tool. This retrospective, noncomparative study was conducted at three tertiary eye care centers. The surgeries recorded were ptosis correction, ectropion correction, dacryocystorhinostomy, angular dermoid excision, enucleation, blepharoplasty and lid tear repair surgery (one each). The recorded videos were reviewed, edited, and checked for clarity, resolution, and reproducibility. The recorded videos were found to be high quality, which allowed for zooming and visualization of the surgical anatomy clearly. Minimal distortion is a drawback that can be effectively addressed during postproduction. The camera, owing to its lightweight and small size, can be mounted on the surgeon's head, thus offering a unique surgeon point-of-view. In our experience, the results were of good quality and reproducible. A head-mounted ultra-HD video recording system is a cheap, high quality, and unobtrusive technique to record surgery and can be a useful teaching tool in external facial and ophthalmic plastic surgery.

Fusion with highly spin polarized HD and D2

International Nuclear Information System (INIS)

Honig, A.; Letzring, S.; Skupsky, S.

1993-01-01

Our experimental efforts over the past 5 years have been aimed at cazrying out ICF shots with spin-polarized 0 fuel. We successfully prepared polarized 0 in HD, and solved the problems of loading target shells with our carefully prepared isotopic -rnixt.l.l?-es, polarizing them so that the 0 polarization remains metastably frozen-in for about half a day, and carrying out the various cold transfer requirements at Syracuse, where the target is prepared, and at Rochester, where the cold target is inserted fusion chamber. Upon shooting the accurately positioned unpolarized high density cold target, no neutron yield was observed. Inspection inside the OMEGA tank after the shot indicated the absence of neutron yield was dus to mal-timing or insufficient retraction rate of OMEGA'S fast shroud mechanism, resulting in interception of at least 20 of the 24 laser beams by the faulty shroud. In spits of this, all alements of the complex experiment we originally undertook have been successfully demonstrated, and the cold retrieval concepts and methods we developed are being utilized on the ICF upgrades at Rochester and at Livermore. In addition to the solution of the interface problems, we obtained novel results on polymer shell characteristics at low temperatures, and continuation of these experiments is c = ently supported by KLUP. Extensive additional mappings were ca=ied out of nuclear spin relaxation rates of H and D in solid HD in the temperature-magnetic field rangs of 0.01 to 4.2K and 0 - 13 Tesla. New phenomena were discovered, such as association of impurity clustering with very low temperature motion, and inequality of the growth-rate and decay-rate of the magnetization

Characterization of a highly toxic strain of Bacillus thuringiensis serovar kurstaki very similar to the HD-73 strain.

Science.gov (United States)

Reinoso-Pozo, Yaritza; Del Rincón-Castro, Ma Cristina; Ibarra, Jorge E

2016-09-01

The LBIT-1200 strain of Bacillus thuringiensis was recently isolated from soil, and showed a 6.4 and 9.5 increase in toxicity, against Manduca sexta and Trichoplusia ni, respectively, compared to HD-73. However, LBIT-1200 was still highly similar to HD-73, including the production of bipyramidal crystals containing only one protein of ∼130 000 kDa, its flagellin gene sequence related to the kurstaki serotype, plasmid and RepPCR patterns similar to HD-73, no production of β-exotoxin and no presence of VIP genes. Sequencing of its cry gene showed the presence of a cry1Ac-type gene with four amino acid differences, including two amino acid replacements in domain III, compared to Cry1Ac1, which may explain its higher toxicity. In conclusion, the LBIT-1200 strain is a variant of the HD-73 strain but shows a much higher toxicity, which makes this new strain an important candidate to be developed as a bioinsecticide, once it passes other tests, throughout its biotechnological development. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Banana (Musa. spp.) strain HD-1 appraisal

International Nuclear Information System (INIS)

Longyan, G.; Xinguo, L.; Lingxia, W.; Xuefei, J.

2016-01-01

Being one of the important tropical and subtropical fruit trees, banana (Musa spp.) belongs to the family Musaceae and the order Scitaminae with two genera, Musa and Ensete. In a field survey, research team has discovered a potential banana mutant strain HD-1 with a sound economic value. The results of the finding are as follows: based on Simmonds classification, the pseudostem of banana strain HD-1 is relatively short and purplish red; its upright outward petiole groove has red edges and wraps its pseudostem loosely. Its ploidy is 3, AAA type. Karyotype analysis shows that the number of chromosomes is 33, the karyotype formula is 2n=3x=33=2L + 3 M2 + 4 M1 + 2 S, HD-1 is classified as 1B type. With the help of ISSR molecular markers, we find thatbanana HD-1 has the closest relationship with Pubei and Tianbao dwarf banana; the similarity coefficient is 0.81. In an artificial simulation tests of cold, drought and salt resistance environment changes of physiological and biochemical indexes indicate that HD-1 exhibits stronger defense capability than Brazil banana. By way of inoculation with injury of root dipping method, we respectively treat two kinds of banana seedlings inoculated Banana Fusarium wilt race 4 small species. The results show that their resistance evaluation scores are 3 and 4, disease levels are susceptible and high sensitivity respectively. We conclude that HD-1 has stronger resistance ability to Fusarium wilt than Brazil banana. (author)

Effect of high pN2 and high pD2 on NH3 production, H2 evolution, and HD formation by nitrogenases

International Nuclear Information System (INIS)

Jensen, B.B.; Burris, R.H.

1985-01-01

We have investigated the effect of the partial pressure of N2 and D2 on HD formation, H2 evolution, and NH3 production by nitrogenase from Klebsiella pneumoniae and Clostridium pasteurianum. By using pressures up to 4 atm, we have been able to extend the concentration range of N2 and D2 in our investigations beyond that used in previous studies. The pN2 dependence of HD formation with constant pD2 ideally shows no HD formation under zero pN2, reaches a peak which depends on the pD2, and then decreases to zero at very high pN2. K. pneumoniae and C. pasteurianum nitrogenases differ in their Ki(D2) for nitrogen fixation. C. pasteurianum nitrogenase had the lower activity for formation of HD. With K. pneumoniae nitrogenase, D2 enhanced H2 evolution from 31% of the electron flux partitioned to H2 in the absence of D2 to 51% of the electron flux partitioned to H2 at 400 kPa of D2. With C. pasteurianum nitrogenase, the equivalent values were 33% and 48% of the total electron flux. Our results support previou findings on the mechanism for nitrogenase-catalyzed reductions proposed by W. W. Cleland

Effects of Anodal High-Definition Transcranial Direct Current Stimulation on Bilateral Sensorimotor Cortex Activation During Sequential Finger Movements: An fNIRS Study.

Science.gov (United States)

Muthalib, Makii; Besson, Pierre; Rothwell, John; Ward, Tomas; Perrey, Stephane

2016-01-01

Transcranial direct current stimulation (tDCS) is a non-invasive electrical brain stimulation technique that can modulate cortical neuronal excitability and activity. This study utilized functional near infrared spectroscopy (fNIRS) neuroimaging to determine the effects of anodal high-definition (HD)-tDCS on bilateral sensorimotor cortex (SMC) activation. Before (Pre), during (Online), and after (Offline) anodal HD-tDCS (2 mA, 20 min) targeting the left SMC, eight healthy subjects performed a simple finger sequence (SFS) task with their right or left hand in an alternating blocked design (30-s rest and 30-s SFS task, repeated five times). In order to determine the level of bilateral SMC activation during the SFS task, an Oxymon MkIII fNIRS system was used to measure from the left and right SMC, changes in oxygenated (O2Hb) and deoxygenated (HHb) haemoglobin concentration values. The fNIRS data suggests a finding that compared to the Pre condition both the "Online" and "Offline" anodal HD-tDCS conditions induced a significant reduction in bilateral SMC activation (i.e., smaller decrease in HHb) for a similar motor output (i.e., SFS tap rate). These findings could be related to anodal HD-tDCS inducing a greater efficiency of neuronal transmission in the bilateral SMC to perform the same SFS task.

Research on compression performance of ultrahigh-definition videos

Science.gov (United States)

Li, Xiangqun; He, Xiaohai; Qing, Linbo; Tao, Qingchuan; Wu, Di

2017-11-01

With the popularization of high-definition (HD) images and videos (1920×1080 pixels and above), there are even 4K (3840×2160) television signals and 8 K (8192×4320) ultrahigh-definition videos. The demand for HD images and videos is increasing continuously, along with the increasing data volume. The storage and transmission cannot be properly solved only by virtue of the expansion capacity of hard disks and the update and improvement of transmission devices. Based on the full use of the coding standard high-efficiency video coding (HEVC), super-resolution reconstruction technology, and the correlation between the intra- and the interprediction, we first put forward a "division-compensation"-based strategy to further improve the compression performance of a single image and frame I. Then, by making use of the above thought and HEVC encoder and decoder, a video compression coding frame is designed. HEVC is used inside the frame. Last, with the super-resolution reconstruction technology, the reconstructed video quality is further improved. The experiment shows that by the proposed compression method for a single image (frame I) and video sequence here, the performance is superior to that of HEVC in a low bit rate environment.

Fusion with highly spin polarized HD and D2

International Nuclear Information System (INIS)

Honig, A.

1992-01-01

This report discusses the following topics relating to inertial confinement with spin polarized hydrogen targets: low temperature implementation of mating a target to omega; dilution-refrigerator cold-entry and retrieval system; target shell tensile strength characterization at low temperatures; and proton and deuteron spin-lattice relaxation measurements in HD in the millikelvin temperature range

Intensity, Duration, and Location of High-Definition Transcranial Direct Current Stimulation for Tinnitus Relief.

Science.gov (United States)

Shekhawat, Giriraj Singh; Sundram, Frederick; Bikson, Marom; Truong, Dennis; De Ridder, Dirk; Stinear, Cathy M; Welch, David; Searchfield, Grant D

2016-05-01

Tinnitus is the perception of a phantom sound. The aim of this study was to compare current intensity (center anode 1 mA and 2 mA), duration (10 minutes and 20 minutes), and location (left temporoparietal area [LTA] and dorsolateral prefrontal cortex [DLPFC]) using 4 × 1 high-definition transcranial direct current stimulation (HD-tDCS) for tinnitus reduction. Twenty-seven participants with chronic tinnitus (>2 years) and mean age of 53.5 years underwent 2 sessions of HD-tDCS of the LTA and DLPFC in a randomized order with a 1 week gap between site of stimulation. During each session, a combination of 4 different settings were used in increasing dose (1 mA, 10 minutes; 1 mA, 20 minutes; 2 mA, 10 minutes; and 2 mA, 20 minutes). The impact of different settings on tinnitus loudness and annoyance was documented. Twenty-one participants (77.78%) reported a minimum of 1 point reduction on tinnitus loudness or annoyance scales. There were significant changes in loudness and annoyance for duration of stimulation,F(1, 26) = 10.08,Ptinnitus relief. The stimulation of the LTA and DLPFC were equally effective for suppressing tinnitus loudness and annoyance. © The Author(s) 2015.

High-Definition Medicine.

Science.gov (United States)

Torkamani, Ali; Andersen, Kristian G; Steinhubl, Steven R; Topol, Eric J

2017-08-24

The foundation for a new era of data-driven medicine has been set by recent technological advances that enable the assessment and management of human health at an unprecedented level of resolution-what we refer to as high-definition medicine. Our ability to assess human health in high definition is enabled, in part, by advances in DNA sequencing, physiological and environmental monitoring, advanced imaging, and behavioral tracking. Our ability to understand and act upon these observations at equally high precision is driven by advances in genome editing, cellular reprogramming, tissue engineering, and information technologies, especially artificial intelligence. In this review, we will examine the core disciplines that enable high-definition medicine and project how these technologies will alter the future of medicine. Copyright © 2017 Elsevier Inc. All rights reserved.

Robust and efficient fiducial tracking for augmented reality in HD-laparoscopic video streams

Science.gov (United States)

Mueller, M.; Groch, A.; Baumhauer, M.; Maier-Hein, L.; Teber, D.; Rassweiler, J.; Meinzer, H.-P.; Wegner, In.

2012-02-01

Augmented Reality (AR) is a convenient way of porting information from medical images into the surgical field of view and can deliver valuable assistance to the surgeon, especially in laparoscopic procedures. In addition, high definition (HD) laparoscopic video devices are a great improvement over the previously used low resolution equipment. However, in AR applications that rely on real-time detection of fiducials from video streams, the demand for efficient image processing has increased due to the introduction of HD devices. We present an algorithm based on the well-known Conditional Density Propagation (CONDENSATION) algorithm which can satisfy these new demands. By incorporating a prediction around an already existing and robust segmentation algorithm, we can speed up the whole procedure while leaving the robustness of the fiducial segmentation untouched. For evaluation purposes we tested the algorithm on recordings from real interventions, allowing for a meaningful interpretation of the results. Our results show that we can accelerate the segmentation by a factor of 3.5 on average. Moreover, the prediction information can be used to compensate for fiducials that are temporarily occluded or out of scope, providing greater stability.

THREE-DIMENSIONAL ATMOSPHERIC CIRCULATION MODELS OF HD 189733b AND HD 209458b WITH CONSISTENT MAGNETIC DRAG AND OHMIC DISSIPATION

International Nuclear Information System (INIS)

Rauscher, Emily; Menou, Kristen

2013-01-01

We present the first three-dimensional circulation models for extrasolar gas giant atmospheres with geometrically and energetically consistent treatments of magnetic drag and ohmic dissipation. Atmospheric resistivities are continuously updated and calculated directly from the flow structure, strongly coupling the magnetic effects with the circulation pattern. We model the hot Jupiters HD 189733b (T eq ≈ 1200 K) and HD 209458b (T eq ≈ 1500 K) and test planetary magnetic field strengths from 0 to 30 G. We find that even at B = 3 G the atmospheric structure and circulation of HD 209458b are strongly influenced by magnetic effects, while the cooler HD 189733b remains largely unaffected, even in the case of B = 30 G and super-solar metallicities. Our models of HD 209458b indicate that magnetic effects can substantially slow down atmospheric winds, change circulation and temperature patterns, and alter observable properties. These models establish that longitudinal and latitudinal hot spot offsets, day-night flux contrasts, and planetary radius inflation are interrelated diagnostics of the magnetic induction process occurring in the atmospheres of hot Jupiters and other similarly forced exoplanets. Most of the ohmic heating occurs high in the atmosphere and on the dayside of the planet, while the heating at depth is strongly dependent on the internal heat flux assumed for the planet, with more heating when the deep atmosphere is hot. We compare the ohmic power at depth in our models, and estimates of the ohmic dissipation in the bulk interior (from general scaling laws), to evolutionary models that constrain the amount of heating necessary to explain the inflated radius of HD 209458b. Our results suggest that deep ohmic heating can successfully inflate the radius of HD 209458b for planetary magnetic field strengths of B ≥ 3-10 G.

Development of the HD-Teen Inventory.

Science.gov (United States)

Driessnack, Martha; Williams, Janet K; Barnette, J Jackson; Sparbel, Kathleen J; Paulsen, Jane S

2012-05-01

Adolescents, who have a parent with Huntington Disease (HD), not only are at genetic risk for HD but also are witness to its onset and devastating clinical progression as their parent declines. To date, no mechanism has been developed to direct health care providers to the atypical adolescent experiences of these teens. The purpose of this report is to describe the process of developing the HD-Teen Inventory clinical assessment tool. Forty-eight teens and young adults from 19 U.S. states participated in the evaluation of the HD-Teen Inventory tool. Following item analysis, the number of items was reduced and item frequency and reaction scales were combined, based on the strong correlation (r = .94). The resultant tool contains 15 inventory and 2 open-ended response items. The HD-Teen Inventory emerged as a more compact and efficient tool for identifying the most salient concerns of at-risk teens in HD families in research and/or clinical practice.

DISEQUILIBRIUM CARBON, OXYGEN, AND NITROGEN CHEMISTRY IN THE ATMOSPHERES OF HD 189733b AND HD 209458b

International Nuclear Information System (INIS)

Moses, Julianne I.; Visscher, C.; Fortney, J. J.; Showman, A. P.; Lewis, N. K.; Griffith, C. A.; Klippenstein, S. J.; Shabram, M.; Friedson, A. J.; Marley, M. S.; Freedman, R. S.

2011-01-01

We have developed a one-dimensional photochemical and thermochemical kinetics and diffusion model to study the effects of disequilibrium chemistry on the atmospheric composition of 'hot-Jupiter' exoplanets. Here we investigate the coupled chemistry of neutral carbon, hydrogen, oxygen, and nitrogen species on HD 189733b and HD 209458b and we compare the model results with existing transit and eclipse observations. We find that the vertical profiles of molecular constituents are significantly affected by transport-induced quenching and photochemistry, particularly on the cooler HD 189733b; however, the warmer stratospheric temperatures on HD 209458b help maintain thermochemical equilibrium and reduce the effects of disequilibrium chemistry. For both planets, the methane and ammonia mole fractions are found to be enhanced over their equilibrium values at pressures of a few bar to less than an mbar due to transport-induced quenching, but CH 4 and NH 3 are photochemically removed at higher altitudes. Disequilibrium chemistry also enhances atomic species, unsaturated hydrocarbons (particularly C 2 H 2 ), some nitriles (particularly HCN), and radicals like OH, CH 3 , and NH 2 . In contrast, CO, H 2 O, N 2 , and CO 2 more closely follow their equilibrium profiles, except at pressures ∼ 2 O, and N 2 are photochemically destroyed and CO 2 is produced before its eventual high-altitude destruction. The enhanced abundances of CH 4 , NH 3 , and HCN are expected to affect the spectral signatures and thermal profiles of HD 189733b and other relatively cool, transiting exoplanets. We examine the sensitivity of our results to the assumed temperature structure and eddy diffusion coefficients and discuss further observational consequences of these models.

Evidences of extragalactic origin and planet engulfment in the metal-poor twin pair HD 134439/HD 134440

Science.gov (United States)

Reggiani, Henrique; Meléndez, Jorge

2018-04-01

Recent studies of chemical abundances in metal-poor halo stars show the existence of different populations, which is important for studies of Galaxy formation and evolution. Here, we revisit the twin pair of chemically anomalous stars HD 134439 and HD 134440, using high resolution (R ˜ 72 000) and high S/N ratio (S/N ˜ 250) HDS/Subaru spectra. We compare them to the well-studied halo star HD 103095, using the line-by-line differential technique to estimate precise stellar parameters and LTE chemical abundances. We present the abundances of C, O, Na, Mg, Si, Ca, Sc, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, Sr, Y, Ba, La, Ce, Nd, and Sm. We compare our results to the precise abundance patterns of Nissen & Schuster (2010) and data from dwarf Spheroidal galaxies (dSphs). We show that the abundance pattern of these stars appears to be closely linked to that of dSphs with [α/Fe] knee below [Fe/H] < -1.5. We also find a systematic difference of 0.06 ± 0.01 dex between the abundances of these twin binary stars, which could be explained by the engulfment of a planet, thus suggesting that planet formation is possible at low metallicities ([Fe/H] = -1.4).

The use of high definition colonoscopy versus standard definition: does it affect polyp detection rate?

Science.gov (United States)

Richardson, John; Thaventhiran, Anthony; Mackenzie, Hugh; Stubbs, Benjamin

2017-11-03

Polyp detection rate (PDR) during lower gastrointestinal endoscopy (LGIE) is of clinical importance. Detecting adenomatous polyps early in the adenoma-carcinoma sequence can halt disease progression, enabling treatment at a favourable stage. High definition colonoscopy (HDC) has been used in our hospital alongside standard definition equipment since 2011. We aim to determine what affect the use of HDC has on PDR. Post-hoc analysis of a prospectively maintained database on all patients undergoing LGIE was performed (01/01/2012-31/12/2015), n = 15,448. Analysis tested the primary outcome of HD's effect on PDR across LGIE and secondary outcome stratified this by endoscopist group (Physician (PE), Surgeon (SE) and Nurse Endoscopist (NE)). Of 15,448 patients, 1353 underwent HDC. Unmatched analysis showed PDR increased by 5.3% in this group (p < 0.001). Matched analysis considered 2288 patients from the total cohort (1144 HDC) and showed an increase of 1% in PDR with HDC (p = 0.578). Further unmatched analysis stratified by endoscopist groups showed a PDR increase of 1.8% (p = 0.375), 5.4% (p = 0.008) and 4.6% (p = 0.021) by PE, SE and NE respectively. Matched analysis demonstrated an increase of 1% (p = 0.734) and 1.5% (p = 0.701) amongst PE and NE, with a decrease of 0.6% (p = 0.883) by SE. The introduction of HDC increased PDR across all LGIE in our hospital, though this was not clinically significant. This marginal benefit was present across all endoscopist groups with no group benefiting over another in matched analysis.

Effect of Blood Collection Tube Type and Time to Processing on the Enumeration and High-Content Characterization of Circulating Tumor Cells Using the High-Definition Single-Cell Assay.

Science.gov (United States)

Rodríguez-Lee, Mariam; Kolatkar, Anand; McCormick, Madelyn; Dago, Angel D; Kendall, Jude; Carlsson, Nils Anders; Bethel, Kelly; Greenspan, Emily J; Hwang, Shelley E; Waitman, Kathryn R; Nieva, Jorge J; Hicks, James; Kuhn, Peter

2018-02-01

- As circulating tumor cell (CTC) assays gain clinical relevance, it is essential to address preanalytic variability and to develop standard operating procedures for sample handling in order to successfully implement genomically informed, precision health care. - To evaluate the effects of blood collection tube (BCT) type and time-to-assay (TTA) on the enumeration and high-content characterization of CTCs by using the high-definition single-cell assay (HD-SCA). - Blood samples of patients with early- and advanced-stage breast cancer were collected into cell-free DNA (CfDNA), EDTA, acid-citrate-dextrose solution, and heparin BCTs. Time-to-assay was evaluated at 24 and 72 hours, representing the fastest possible and more routine domestic shipping intervals, respectively. - We detected the highest CTC levels and the lowest levels of negative events in CfDNA BCT at 24 hours. At 72 hours in this BCT, all CTC subpopulations were decreased with the larger effect observed in high-definition CTCs and cytokeratin-positive cells smaller than white blood cells. Overall cell retention was also optimal in CfDNA BCT at 24 hours. Whole-genome copy number variation profiles were generated from single cells isolated from all BCT types and TTAs. Cells from CfDNA BCT at 24-hour TTA exhibited the least noise. - Circulating tumor cells can be identified and characterized under a variety of collection, handling, and processing conditions, but the highest quality can be achieved with optimized conditions. We quantified performance differences of the HD-SCA for specific preanalytic variables that may be used as a guide to develop best practices for implementation into patient care and/or research biorepository processes.

TWO SMALL PLANETS TRANSITING HD 3167

International Nuclear Information System (INIS)

Vanderburg, Andrew; Bieryla, Allyson; Latham, David W.; Mayo, Andrew W.; Berlind, Perry; Duev, Dmitry A.; Jensen-Clem, Rebecca; Kulkarni, Shrinivas; Riddle, Reed; Baranec, Christoph; Law, Nicholas M.; Nieberding, Megan N.; Salama, Maïssa

2016-01-01

We report the discovery of two super-Earth-sized planets transiting the bright (V = 8.94, K = 7.07) nearby late G-dwarf HD 3167, using data collected by the K2 mission. The inner planet, HD 3167 b, has a radius of 1.6 R ⊕ and an ultra-short orbital period of only 0.96 days. The outer planet, HD 3167 c, has a radius of 2.9 R ⊕ and orbits its host star every 29.85 days. At a distance of just 45.8 ± 2.2 pc, HD 3167 is one of the closest and brightest stars hosting multiple transiting planets, making HD 3167 b and c well suited for follow-up observations. The star is chromospherically inactive with low rotational line-broadening, ideal for radial velocity observations to measure the planets’ masses. The outer planet is large enough that it likely has a thick gaseous envelope that could be studied via transmission spectroscopy. Planets transiting bright, nearby stars like HD 3167 are valuable objects to study leading up to the launch of the James Webb Space Telescope .

CHARACTERIZING THE RIGIDLY ROTATING MAGNETOSPHERE STARS HD 345439 AND HD 23478

Energy Technology Data Exchange (ETDEWEB)

Wisniewski, J. P.; Lomax, J. R. [Homer L. Dodge Department of Physics and Astronomy, The University of Oklahoma, 440 W. Brooks Street, Norman, OK 73019 (United States); Chojnowski, S. D. [Department of Astronomy, New Mexico State University, 1780 E University Avenue, Las Cruces, NM 88003 (United States); Davenport, J. R. A. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Bartz, J.; Pepper, J. [Lehigh University, Department of Physics, 413 Deming Lewis Lab, 16 Memorial Drive, East Bethlehem, PA 18015 (United States); Whelan, D. G. [Department of Physics, Austin College, 900 N. Grand Avenue, Sherman, TX 75090 (United States); Eikenberry, S. S. [Department of Astronomy, University of Florida, 211 Bryant Space Science Center, Gainesville, FL 32611 (United States); Majewski, S. R.; Skrutskie, M. [Department of Astronomy, University of Virginia, P.O. Box 400325, Charlottesville, VA 22904-4325 (United States); Richardson, N. D., E-mail: wisniewski@ou.edu [Département de Physique and Centre de Recherche en Astrophysique du Québec (CRAQ), Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, QC H3C 3J7 (Canada)

2015-10-01

The SDSS III APOGEE survey recently identified two new σ Ori E type candidates, HD 345439 and HD 23478, which are a rare subset of rapidly rotating massive stars whose large (kGauss) magnetic fields confine circumstellar material around these systems. Our analysis of multi-epoch photometric observations of HD 345439 from the Kilodegree Extremely Little Telescope, Wide Angle Search for Planets, and ASAS surveys reveals the presence of a ∼0.7701 day period in each data set, suggesting the system is among the faster known σ Ori E analogs. We also see clear evidence that the strength of Hα, H i Brackett series lines, and He i lines also vary on a ∼0.7701 day period from our analysis of multi-epoch, multi-wavelength spectroscopic monitoring of the system from the APO 3.5 m telescope. We trace the evolution of select emission line profiles in the system, and observe coherent line profile variability in both optical and infrared H i lines, as expected for rigidly rotating magnetosphere stars. We also analyze the evolution of the H i Br-11 line strength and line profile in multi-epoch observations of HD 23478 from the SDSS-III APOGEE instrument. The observed periodic behavior is consistent with that recently reported by Sikora and collaborators in optical spectra.

HD271791: dynamical versus binary-supernova ejection scenario

OpenAIRE

Gvaramadze, V. V.

2009-01-01

The atmosphere of the extremely high-velocity (530-920 km/s) early B-type star HD271791 is enriched in $\\alpha$-process elements, which suggests that this star is a former secondary component of a massive tight binary system and that its surface was polluted by the nucleosynthetic products after the primary star exploded in a supernova. It was proposed that the (asymmetric) supernova explosion unbind the system and that the secondary star (HD271791) was released at its orbital velocity in the...

The impact of reinforcement contingencies on AD/HD: a review and theoretical appraisal.

Science.gov (United States)

Luman, Marjolein; Oosterlaan, Jaap; Sergeant, Joseph A

2005-02-01

One of the core deficits in attention deficit/hyperactivity disorder (AD/HD) is thought to be an aberrant sensitivity to reinforcement, such as reward and response cost. Twenty-two studies (N=1181 children) employing AD/HD and reinforcement contingencies are reviewed from vantage points: task performance, motivation, and psychophysiology. Results indicate that reinforcement contingencies have a positive impact on task performance and levels of motivation for both children with AD/HD and normal controls. There is evidence that the effect related to task performance is somewhat more prominent in AD/HD. There is some evidence that a high intensity of reinforcement is highly effective in AD/HD. Children with AD/HD prefer immediate over delayed reward. From a psychophysiological point of view, children with AD/HD seem less sensitive to reinforcement compared to controls. While comorbid disorders are suggested to be confounders of the dependent variables, many studies do not examine the effect of oppositional defiant disorder (ODD) and conduct disorder (CD). We discuss the implications of the findings for five theoretical frameworks, including the model by, the cognitive-energetic model (CEM), the dual-pathway model and the BIS/BAS model. Results show a discrepancy between the theoretical models and the behavioural findings.

TWO SMALL PLANETS TRANSITING HD 3167

Energy Technology Data Exchange (ETDEWEB)

Vanderburg, Andrew; Bieryla, Allyson; Latham, David W.; Mayo, Andrew W.; Berlind, Perry [Harvard–Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Duev, Dmitry A.; Jensen-Clem, Rebecca; Kulkarni, Shrinivas; Riddle, Reed [California Institute of Technology, Pasadena, CA 91125 (United States); Baranec, Christoph [University of Hawai‘i at Mānoa, Hilo, HI 96720 (United States); Law, Nicholas M. [University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States); Nieberding, Megan N. [National Optical Astronomy Observatory, 950 N. Cherry Avenue, Tucson, AZ 85719 (United States); Salama, Maïssa, E-mail: avanderburg@cfa.harvard.edu [University of Hawai‘i at Mānoa, Honolulu, HI 96822 (United States)

2016-09-20

We report the discovery of two super-Earth-sized planets transiting the bright (V = 8.94, K = 7.07) nearby late G-dwarf HD 3167, using data collected by the K2 mission. The inner planet, HD 3167 b, has a radius of 1.6 R {sub ⊕} and an ultra-short orbital period of only 0.96 days. The outer planet, HD 3167 c, has a radius of 2.9 R {sub ⊕} and orbits its host star every 29.85 days. At a distance of just 45.8 ± 2.2 pc, HD 3167 is one of the closest and brightest stars hosting multiple transiting planets, making HD 3167 b and c well suited for follow-up observations. The star is chromospherically inactive with low rotational line-broadening, ideal for radial velocity observations to measure the planets’ masses. The outer planet is large enough that it likely has a thick gaseous envelope that could be studied via transmission spectroscopy. Planets transiting bright, nearby stars like HD 3167 are valuable objects to study leading up to the launch of the James Webb Space Telescope .

HD5980

Science.gov (United States)

Koenigsberger, C.

HD5980 is a multiple system containing at least 3 very massive and luminous stars. Located in the Small Magellanic Cloud, it is an ideal system for studying the massive star structure and evolutionary processes in low-metallicity environments. Intensely observed over the past few decades, HD5980 is a treasure trove of information on stellar wind structure, on wind-wind collisions and on the formation of wind-blown circumstellar structures. In addition, its characteristics suggest that the eclipsing WR+LBV stars of the system are the product of quasihomogeneous chemical evolution, thus making them candidate pair production supernovae or GRB progenitors. This paper summarizes some of the outstanding results derived from half a century of observations and recent theoretical studies.

HIGH-TEMPERATURE PHOTOCHEMISTRY IN THE ATMOSPHERE OF HD 189733b

International Nuclear Information System (INIS)

Line, M. R.; Yung, Y. L.; Liang, M. C.

2010-01-01

Recent infrared spectroscopy of hot exoplanets is beginning to reveal their atmospheric composition. Deep within the planetary atmosphere, the composition is controlled by thermochemical equilibrium. Photochemistry becomes important higher in the atmosphere, at levels above ∼1 bar. These two chemistries compete between ∼1 and 10 bars in hot-Jupiter-like atmospheres, depending on the strength of the eddy mixing and temperature. HD 189733b provides an excellent laboratory in which to study the consequences of chemistry of hot atmospheres. The recent spectra of HD 189733b contain signatures of CH 4 , CO 2 , CO, and H 2 O. Here we identify the primary chemical pathways that govern the abundances of CH 4 , CO 2 , CO, and H 2 O in the cases of thermochemical equilibrium chemistry, photochemistry, and their combination. Our results suggest that the disequilibrium mechanisms can significantly enhance the abundances of these species above their thermochemical equilibrium value, so some caution must be taken when assuming that an atmosphere is in strict thermochemical equilibrium.

Radiolabeling optimization and reduced staff radiation exposure for high-dose 90Y-ibritumomab tiuxetan (HD-Zevalin)

International Nuclear Information System (INIS)

Papi, Stefano; Martano, Luigi; Garaboldi, Lucia; Rossi, Annalisa; Cremonesi, Marta; Grana, Chiara Maria; Paolucci, Daniele; Sansovini, Maddalena; Paganelli, Giovanni; Chinol, Marco

2010-01-01

Introduction: 90 Y-Zevalin labeling may cause severe finger radiation exposure, especially in high-dose protocols (HD-Zevalin), where up to 7.4 GBq could be injected. In this work, we optimized the labeling of HD-Zevalin with special regard to simplicity, speed, safety and radiation protection. Methods: Factors influencing labeling outcome (activity, specific activity, time, final volume, stability) were studied separately. The critical steps of a standard radiolabeling procedure were optimized to reduce finger exposure, developing an alternative labeling procedure and including a different 90 Y supplier. Finger doses were monitored by thermoluminescent dosimeters at each fingertip under anti-X gloves, considering both absolute values and values after normalization to 1.48 GBq. Results: Labeling of 90 Y-Zevalin was safe and reproducible up to 7.4 GBq with a simple and single-step procedure offering good stability for several hours. Radiolabeling specific activity was found critical, being kept at 740 MBq.mg -1 . Radiochemical purity values ≥98% were routinely achieved. The alternative procedure allowed a sensible reduction of finger dose, due to both the different 90 Y vial and the handling. Finger exposure was reduced from 6.6±4.3 to 3.1±0.8 mSv/1.48 GBq in the case of the original 90 Y vial and from 1.5±0.9 to 0.3±0.1 mSv/1.48 GBq using a shielded 90 Y vial. Conclusions: HD-Zevalin can be prepared in a safe and reproducible way, giving high radiochemical purity values, good stability and low finger exposure. This study may improve the safety of nuclear medicine professionals involved in the preparation of Zevalin.

A Memory Hierarchy Model Based on Data Reuse for Full-Search Motion Estimation on High-Definition Digital Videos

Directory of Open Access Journals (Sweden)

Alba Sandyra Bezerra Lopes

2012-01-01

Full Text Available The motion estimation is the most complex module in a video encoder requiring a high processing throughput and high memory bandwidth, mainly when the focus is high-definition videos. The throughput problem can be solved increasing the parallelism in the internal operations. The external memory bandwidth may be reduced using a memory hierarchy. This work presents a memory hierarchy model for a full-search motion estimation core. The proposed memory hierarchy model is based on a data reuse scheme considering the full search algorithm features. The proposed memory hierarchy expressively reduces the external memory bandwidth required for the motion estimation process, and it provides a very high data throughput for the ME core. This throughput is necessary to achieve real time when processing high-definition videos. When considering the worst bandwidth scenario, this memory hierarchy is able to reduce the external memory bandwidth in 578 times. A case study for the proposed hierarchy, using 32×32 search window and 8×8 block size, was implemented and prototyped on a Virtex 4 FPGA. The results show that it is possible to reach 38 frames per second when processing full HD frames (1920×1080 pixels using nearly 299 Mbytes per second of external memory bandwidth.

HD 101065, the Most Peculiar Star: First Results from Precise Radial ...

Indian Academy of Sciences (India)

Abstract. In this paper we discuss the prospects for asteroseismology with spatial resolution and motivate studies of the most chemically peculiar. roAp star HD 101065. We present the first results from a high-precision radial velocity (RV) study of HD 101065 based on data spanning four nights that were acquired using the ...

Efforts towards a dynamically polarised HD-target

International Nuclear Information System (INIS)

Radtke, E.; Goertz, St.; Harmsen, J.; Heckmann, J.; Meier, A.; Meyer, W.; Reicherz, G.

2004-01-01

The molecular hydrogen isotopes contain no unpolarisable background. From this point of view they appear to be the material of choice for a polarised bulk target in scattering experiments. The fast nuclear relaxation of H 2 and D 2 is one reason that these substances are not highly polarisable. This fact brings hydrogendeuteride (HD) into focus. In Bochum a device to freeze out gases into the consisting 4 He-cryostat has been built up. The principle of the Dynamic Nuclear Polarisation requires a sufficient amount of paramagnetic electrons. These have been produced by cracking HD molecules at 1 K using a 90 Sr β-source with an activity of 3.7 GBq. Six days of effective irradiation resulted in a density of paramagnetic centres in the order of 10 18 spins/cm 3 . This could be estimated from bolometric electron paramagnetic resonance (EPR) measurements. Dynamic polarisation could not be achieved. This is accounted to isotopic impurities in the used HD, which accelerate the nuclear relaxation. The constant of ortho-para conversion in H 2 could be confirmed to be 1.9%/h

Distillation of hydrogen isotopes for polarized HD targets

Energy Technology Data Exchange (ETDEWEB)

Ohta, T., E-mail: takeshi@rcnp.osaka-u.ac.jp [Research Center for Nuclear Physics, Osaka University, Mihogaoka 10-1, Ibaraki, Osaka 567-0047 (Japan); Bouchigny, S. [IN2P3, Institut de Physique Nucleaire, F-91406 Orsay (France); CEA LIST, BP6-92265 Fontenay-aux-Roses, CEDEX (France); Didelez, J.-P. [IN2P3, Institut de Physique Nucleaire, F-91406 Orsay (France); Fujiwara, M. [Research Center for Nuclear Physics, Osaka University, Mihogaoka 10-1, Ibaraki, Osaka 567-0047 (Japan); Fukuda, K. [Kansai University of Nursing and Health Sciences, Shizuki Awaji 656-2131 (Japan); Kohri, H.; Kunimatsu, T.; Morisaki, C.; Ono, S. [Research Center for Nuclear Physics, Osaka University, Mihogaoka 10-1, Ibaraki, Osaka 567-0047 (Japan); Rouille, G. [IN2P3, Institut de Physique Nucleaire, F-91406 Orsay (France); Tanaka, M. [Kobe Tokiwa University, Ohtani-cho 2-6-2, Nagata, Kobe 653-0838 (Japan); Ueda, K.; Uraki, M.; Utsuro, M. [Research Center for Nuclear Physics, Osaka University, Mihogaoka 10-1, Ibaraki, Osaka 567-0047 (Japan); Wang, S.Y. [Institute of Physics, Academia Sinica, Taipei 11529, Taiwan (China); Department of Physics, National Kaohsiung Normal University, Kaohsiung 824, Taiwan (China); Yosoi, M. [Research Center for Nuclear Physics, Osaka University, Mihogaoka 10-1, Ibaraki, Osaka 567-0047 (Japan)

2012-02-01

We have developed a new cryogenic distillation system to purify Hydrogen-Deuteride (HD) gas for polarized HD targets in LEPS experiments at SPring-8. A small amount of ortho-H{sub 2} ({approx}0.01%) in the HD gas plays an important role in efficiently polarizing the HD target. Since there are 1-5% impurities of H{sub 2} and D{sub 2} in commercially available HD gases, it is necessary to purify the HD gas up to {approx}99.99%. The distillation system is equipped with a cryogenic distillation unit filled with many small stainless steel cells called 'Heli-pack'. The distillation unit consists of a condenser part, a rectification part, and a reboiler part. The unit is kept at the temperature of 17-21 K. The Heli-pack has a large surface area that makes a good contact between gases and liquids. An amount of 5.2 mol of commercial HD gas is fed into the distillation unit. Three trials were carried out to purify the HD gas by changing temperatures (17.5 K and 20.5 K) and gas extraction speeds (1.3 ml/min and 5.2 ml/min). The extracted gas was analyzed using a gas analyzer system combining a quadrupole mass spectrometer with a gas chromatograph. One mol of HD gas with a purity better than 99.99% has been successfully obtained for the first time. The effective NTP (Number of Theoretical Plates), which is an indication of the distillation performances, is obtained to be 37.2{+-}0.6. This value is in good agreement with a designed value of 37.9. The HD target is expected to be efficiently polarized under a well-controlled condition by adding an optimal amount of ortho-H{sub 2} to the purified HD gas.

Development of a new high density (HD) barium meal (Falibaryt HD) for double contrast investigation of the stomach

International Nuclear Information System (INIS)

Dietze, R.

1986-01-01

During the development of a new double contrast barium meal barium sulfate preparations with various densities, additives and particle size distributions were tested. Phantoms made of leather, rubber and the opened stomachs of cows and pigs were used. A HD bariumsulfate suspension (200 - 250% W/V) of low viscosity and suitable grain size spectrum containing additives improving the adherence (e.g. natrium citrate) showed the best quality parameters for an optimal imaging of the fine mucosal relief. (author)

AD/HD Symptoms and Conduct Problems: Similarities and Differences in Maternal Perceptions

Science.gov (United States)

Maniadaki, Katerina; Sonuga-Barke, Edmund; Kakouros, Efthymios; Karaba, Rania

2006-01-01

Several theories attempt to explain the high co-occurrence of Attention Deficit/ Hyperactivity Disorder (AD/HD) and Conduct Problems (CP). A strong possibility is that AD/HD behaviours lead to the development of CP, due to family coercive interaction patterns, maintained through parental false beliefs regarding child problem behaviour. We compared…

HD 30187 B and HD 39927 B: Two suspected nearby hot subdwarfs in resolved binaries (based on observations made with the ESA Hipparcos satellite)

DEFF Research Database (Denmark)

Makarov, V.V.; Fabricius, C.

1999-01-01

Stars: Individual: HD 30187 B -- Stars: Individual: HD 39927 B - Stars: White dwarfs - Stars: Binaries: Visual......Stars: Individual: HD 30187 B -- Stars: Individual: HD 39927 B - Stars: White dwarfs - Stars: Binaries: Visual...

HD 97658 and its super-Earth

Directory of Open Access Journals (Sweden)

Van Grootel V.

2015-01-01

Full Text Available Super-Earths transiting nearby bright stars are key objects that simultaneously allow for accurate measurements of both their mass and radius, providing essential constraints on their internal composition. We present the confirmation, based on Spitzer observations, that the super-Earth HD 97658 b transits its host star. HD 97658 is a low-mass (M* = 0.77 ± 0.05 M⊙ K1 dwarf, as determined from the Hipparcos parallax and stellar evolution modeling. To constrain the planet parameters, we carry out Bayesian global analyses of Keck-HIRES radial velocities, and MOST and Spitzer photometry. HD 97658 b is a massive (MP = 7.55−0.79+0.83 M⊕ and large (RP = 2.247−0.095+0.098 R⊕ at 4.5 μm super-Earth. We investigate the possible internal compositions for HD 97658 b. Our results indicate a large rocky component, by at least 60% by mass, and very little H-He components, at most 2% by mass. We also discuss how future asteroseismic observations can improve the knowledge of the HD 97658 system, in particular by constraining its age.

Structure and function of homodomain-leucine zipper (HD-Zip) proteins.

Science.gov (United States)

Elhiti, Mohamed; Stasolla, Claudio

2009-02-01

Homeodomain-leucine zipper (HD-Zip) proteins are transcription factors unique to plants and are encoded by more than 25 genes in Arabidopsis thaliana. Based on sequence analyses these proteins have been classified into four distinct groups: HD-Zip I-IV. HD-Zip proteins are characterized by the presence of two functional domains; a homeodomain (HD) responsible for DNA binding and a leucine zipper domain (Zip) located immediately C-terminal to the homeodomain and involved in protein-protein interaction. Despite sequence similarities HD-ZIP proteins participate in a variety of processes during plant growth and development. HD-Zip I proteins are generally involved in responses related to abiotic stress, abscisic acid (ABA), blue light, de-etiolation and embryogenesis. HD-Zip II proteins participate in light response, shade avoidance and auxin signalling. Members of the third group (HD-Zip III) control embryogenesis, leaf polarity, lateral organ initiation and meristem function. HD-Zip IV proteins play significant roles during anthocyanin accumulation, differentiation of epidermal cells, trichome formation and root development.

On the origin of the hypervelocity runaway star HD271791

OpenAIRE

Gvaramadze, V. V.

2009-01-01

We discuss the origin of the runaway early B-type star HD271791 and show that its extremely high velocity (\\simeq 530-920 km/s) cannot be explained within the framework of the binary-supernova ejection scenario. Instead, we suggest that HD271791 attained its peculiar velocity in the course of a strong dynamical encounter between two hard massive binaries or via an exchange encounter between a hard massive binary and a very massive star, formed through runaway mergers of ordinary massive stars...

New ALMA Images of the HD 32297 and HD 61005 Debris Disks

Science.gov (United States)

MacGregor, Meredith Ann; Weinberger, Alycia; Wilner, David; Hughes, A. Meredith; debes, John Henry; Redfield, Seth; Donaldson, Jessica; Nesvold, Erika; Schneider, Glenn; Currie, Thayne; Roberge, Aki; Rodriguez, David

2018-01-01

HD 61005 (G-type star, “The Moth") and HD 32297 (A-type star) host two of the most iconic debris disks. Scattered light images show that both disks are nearly edge-on with dramatic swept-back wings of dust. Previous studies have proposed a range of mechanisms to explain this distinctive morphology including interactions with the interstellar medium, secular perturbations of grains by low-density, neutral interstellar gas, and gravitational interactions with an inclined, eccentric companion. We present new observations from the Atacama Large Millimeter/submillimeter Array (ALMA) at 1.3 mm that provide the highest resolution images at millimeter wavelengths to date of both systems. Observations at millimeter wavelengths are especially critical to our understanding of the physical mechanisms shaping the structure of these disks, since the large grains that dominate emission at these wavelengths are less affected by stellar radiation and winds and more reliably trace the underlying planetesimal distribution. We fit models directly to the observed visibilities within a Markov Chain Monte Carlo (MCMC) framework to characterize the continuum emission and place constraints on the structure of these unique debris disks. Our new ALMA images reveal that despite differences in spectral type, both systems are best described by a two-component structure with (1) a parent body belt, and (2) an outer halo aligned with the scattered light disk. Such halos have typically been assumed to be composed of small grains visible in scattered light, so these images are some of the first observational evidence that larger grains may also populate extended halos. In addition, we detect significant 12CO gas emission from HD 32297, and determine a robust upper limit for HD 61005.

Evaluation of the Anterior Segment Angle-to-Angle Scan of Cirrus High-Definition Optical Coherence Tomography and Comparison With Gonioscopy and With the Visante OCT.

Science.gov (United States)

Tun, Tin A; Baskaran, Mani; Tan, Shayne S; Perera, Shamira A; Aung, Tin; Husain, Rahat

2017-01-01

To evaluate the diagnostic performance of the anterior segment angle-to-angle scan of the Cirrus high-definition optical coherence tomography (HD-OCT) in detecting eyes with closed angles. All subjects underwent dark-room gonioscopy by an ophthalmologist. A technician performed anterior segment imaging with Cirrus (n = 202) and Visante OCT (n = 85) under dark-room conditions. All eyes were categorized by two masked graders as per number of closed quadrants. Each quadrant of anterior chamber angle was categorized as a closed angle if posterior trabecular meshwork could not be seen on gonioscopy or if there was any irido-corneal contact anterior to scleral spur in Cirrus and Visante images. An eye was graded as having a closed angle if two or more quadrants were closed. Agreement and area under the curve (AUC) were performed. There were 50 (24.8%) eyes with closed angles. The agreements of closed-angle diagnosis (by eye) between Cirrus HD-OCT and gonioscopy (k = 0.59; 95% confidence interval (CI) 0.45-0.72; AC1 = 0.76) and between Cirrus and Visante OCT (k = 0.65; 95% CI 0.48-0.82, AC1 = 0.77) were moderate. The AUC for diagnosing the eye with gonioscopic closed angle by Cirrus HD-OCT was good (AUC = 0.86; sensitivity = 83.33; specificity = 77.78). The diagnostic performance of Cirrus HD-OCT in detecting the eyes with closed angles was similar to that of Visante (AUC 0.87 vs. 0.9, respectively; P = 0.51). The anterior segment angle-to-angle scans of Cirrus HD-OCT demonstrated similar diagnostic performance as Visante in detecting gonioscopic closed angles. The agreement between Cirrus and gonioscopy for detecting eyes with closed angles was moderate.

THE DISCOVERY OF HD 37605c AND A DISPOSITIVE NULL DETECTION OF TRANSITS OF HD 37605b

International Nuclear Information System (INIS)

Wang, Sharon Xuesong; Wright, Jason T.; Mahadevan, Suvrath; Cochran, William; Endl, Michael; MacQueen, Phillip J.; Kane, Stephen R.; Von Braun, Kaspar; Henry, Gregory W.; Payne, Matthew J.; Ford, Eric B.; Valenti, Jeff A.; Antoci, Victoria; Dragomir, Diana; Matthews, Jaymie M.; Howard, Andrew W.; Marcy, Geoffrey W.; Isaacson, Howard

2012-01-01

We report the radial velocity discovery of a second planetary mass companion to the K0 V star HD 37605, which was already known to host an eccentric, P ∼ 55 days Jovian planet, HD 37605b. This second planet, HD 37605c, has a period of ∼7.5 years with a low eccentricity and an Msin i of ∼3.4 M Jup . Our discovery was made with the nearly 8 years of radial velocity follow-up at the Hobby-Eberly Telescope and Keck Observatory, including observations made as part of the Transit Ephemeris Refinement and Monitoring Survey effort to provide precise ephemerides to long-period planets for transit follow-up. With a total of 137 radial velocity observations covering almost 8 years, we provide a good orbital solution of the HD 37605 system, and a precise transit ephemeris for HD 37605b. Our dynamic analysis reveals very minimal planet-planet interaction and an insignificant transit time variation. Using the predicted ephemeris, we performed a transit search for HD 37605b with the photometric data taken by the T12 0.8 m Automatic Photoelectric Telescope (APT) and the MOST satellite. Though the APT photometry did not capture the transit window, it characterized the stellar activity of HD 37605, which is consistent of it being an old, inactive star, with a tentative rotation period of 57.67 days. The MOST photometry enabled us to report a dispositive null detection of a non-grazing transit for this planet. Within the predicted transit window, we exclude an edge-on predicted depth of 1.9% at the >>10σ level, and exclude any transit with an impact parameter b > 0.951 at greater than 5σ. We present the BOOTTRAN package for calculating Keplerian orbital parameter uncertainties via bootstrapping. We made a comparison and found consistency between our orbital fit parameters calculated by the RVLIN package and error bars by BOOTTRAN with those produced by a Bayesian analysis using MCMC.

Late Thyroid Sequlae after Treatment of Hodgkin's Disease (HD)

International Nuclear Information System (INIS)

Abaza, A.

2012-01-01

To identify the late effects of radio- chemotherapy (CTH) on thyroid gland in long-term survivors (LTS) HD patients regularly attending the pediatric oncology clinic of National Cancer Institute (NCI), 42 LTS (33 males and 9 females) were studied, together with 26 newly-diagnosed (ND) HD patients (15 males and 11 females) and 28 healthy controls. During 3 years period, all patients subjected to through clinical history/ examination. Files of LTS were revised for date of diagnoses, original site (s), stage, histopathological subtypes and dose/ duration of therapy. Clinical examination was done with laying stress on neck examination for thyroid swelling and lymphadenopathy. Lab investigations include hormonal assay of thyroid and parathyroid (T3, T4, TSH, Thyroglobin, and parathormone). In LTS the mean age was 14.9±3.4 yrs. versus 9.5±3.7 yrs. in ND patients. In LTS, treatment modalities included radiotherapy (RT) alone (2.4%), CTH alone (26.2%) or combination chemo-RT (71.4%). The mean followup time was 7.47±2.19 yrs. The incidence of hyper-/hypo-thyroidism was significantly higher in LTS. High TSH was found only among patients who received chemo-RT (11/26) with thyroid irradiation (IR) in the whole neck field. Finally, the study documented that the hyper-/hypo-thyroidism was one of the long-term complication of radio-CTH in HD patients. Recommendations regarding the follow-up of therapy for HD were discussed. New strategies and evidence based surveillance of the long-term effects are needed for dealing with HD, especially in children

The massive multiple system HD 64315

Science.gov (United States)

Lorenzo, J.; Simón-Díaz, S.; Negueruela, I.; Vilardell, F.; Garcia, M.; Evans, C. J.; Montes, D.

2017-10-01

Context. The O6 Vn star HD 64315 is believed to belong to the star-forming region known as NGC 2467, but previous distance estimates do not support this association. Moreover, it has been identified as a spectroscopic binary, but existing data support contradictory values for its orbital period. Aims: We explore the multiple nature of this star with the aim of determining its distance, and understanding its connection to NGC 2467. Methods: A total of 52 high-resolution spectra have been gathered over a decade. We use their analysis, in combination with the photometric data from All Sky Automated Survey and Hipparcos catalogues, to conclude that HD 64315 is composed of at least two spectroscopic binaries, one of which is an eclipsing binary. We have developed our own program to fit four components to the combined line shapes. Once the four radial velocities were derived, we obtained a model to fit the radial-velocity curves using the Spectroscopic Binary Orbit Program (SBOP). We then implemented the radial velocities of the eclipsing binary and the light curves in the Wilson-Devinney code iteratively to derive stellar parameters for its components. We were also able to analyse the non-eclipsing binary, and to derive minimum masses for its components which dominate the system flux. Results: HD 64315 contains two binary systems, one of which is an eclipsing binary. The two binaries are separated by 0.09 arcsec (or 500 AU) if the most likely distance to the system, 5 kpc, is considered. The presence of fainter companions is not excluded by current observations. The non-eclipsing binary (HD 64315 AaAb) has a period of 2.70962901 ± 0.00000021 d. Its components are hotter than those of the eclipsing binary, and dominate the appearance of the system. The eclipsing binary (HD 64315 BaBb) has a shorter period of 1.0189569 ± 0.0000008 d. We derive masses of 14.6 ± 2.3 M⊙ for both components of the BaBb system. They are almost identical; both stars are overfilling their

High-resolution spectroscopic search for the thermal emission of the extrasolar planet HD 217107 b

OpenAIRE

Cubillos, Patricio E.; Rojo, Patricio; Fortney, Jonathan J.

2011-01-01

We analyzed the combined near-infrared spectrum of a star-planet system with thermal emission atmospheric models, based on the composition and physical parameters of the system. The main objective of this work is to obtain the inclination of the orbit, the mass of the exoplanet, and the planet-to-star flux ratio. We present the results of our routines on the planetary system HD 217107, which was observed with the high-resolution spectrograph Phoenix at 2.14 microns. We revisited and tuned a c...

New investigations of polarized solid HD targets

International Nuclear Information System (INIS)

Honig, A.; Whisnant, C.S.

1995-01-01

Polarized solid HD targets in a frozen-spin mode, with superior nuclear physics characteristics and simple operational configurations, have previously been restricted in their deployment due to a disproportionate target production time with respect to utilization time. Recent investigations have yielded frozen-spin polarization lifetimes, at a convenient target temperature of 1.5 K, of nearly a year for both H and D at high holding fields, and of more than a week at sub-Tesla holding fields. These results, taken together with the advent of new interesting spin-physics using relatively weakly ionizing beams, such as polarized photon beams, remove the above impediment and open up the use of polarized solid HD to long duration nuclear spin-physics experiments. Large, multiple targets can be produced, retrieved from the polarization-production apparatus with a cold-transport (4 K) device, stored for very long times in inexpensive (1.5 K, 7 T) cryostats, and introduced 'off-the-shelf' into in-beam cryostats via the portable cold-transport apparatus. Various modes for achieving polarized H and/or D, as well as already achieved and expected polarization values, are reported. Experimental results are given on Kapitza resistance between the solid HD and the cooling wires necessary to obtain low temperatures during the heat-evolving polarization process. 15 mK is achievable using gold-plated aluminum wires, which constitute 15% extraneous nucleons over the number of polarizable H or D nucleons. Application to more highly ionizing beams is also given consideration. ((orig.))

On the origin of the hypervelocity runaway star HD 271791

Science.gov (United States)

Gvaramadze, V. V.

2010-01-01

We discuss the origin of the early-B-type runaway star HD 271791 and show that its extremely high velocity (≃530 - 920km s-1) cannot be explained within the framework of the binary-supernova ejection scenario. Instead, we suggest that HD 271791 attained its peculiar velocity in the course of a strong dynamical encounter between two hard, massive binaries or through an exchange encounter between a hard, massive binary and a very massive star, formed through runaway mergers of ordinary massive stars in the dense core of a young massive star cluster.

Quality control of involved field radiotherapy in the HD 13 and HD 14 trials. Report of the radiotherapy panel of the German Hodgkin Study Group (GHSG)

Energy Technology Data Exchange (ETDEWEB)

Kriz, J.; Haverkamp, U.; Eich, H.T. [University of Muenster, Department of Radiation Oncology, Muenster (Germany); Baues, C. [University of Cologne, Department of Radiation Oncology, Cologne (Germany); Engenhart-Cabillic, R. [University of Marburg, Department of Radiation Oncology, Marburg (Germany); Herfarth, K. [University of Heidelberg, Department of Radiation Oncology, Heidelberg (Germany); Lukas, P. [University of Innsbruck, Department of Radiation Oncology, Innsbruck (Austria); Pluetschow, A.; Fuchs, M.; Engert, A. [University of Cologne, Department of Internal Medicine, Cologne (Germany); Schmidberger, H. [University of Mainz, Department of Radiation Oncology, Mainz (Germany); Staar, S. [Bremen Mitte, Department of Radiation Oncology, Bremen (Germany)

2017-02-15

As part of the foundation of the German Hodgkin Study Group (GHSG) in 1978, a central radiotherapy (RT) reference centre was established to evaluate and to improve the quality of treatment. During the study generations, the quality assurance programs (QAP) were continued and adapted to the demands of each study. The purpose of this article is to demonstrate the results of the fifth study generation and to compare them to the previous findings. With the start of the fourth GHSG study generation (HD10-12), a central prospective review of all diagnostic images was established to create an individual treatment plan for each early stage study patient. The quality of involved field RT was retrospectively evaluated by an expert panel of radiation oncologists. In the fifth study generation (HD13-15), the retrospective review of radiotherapy performed was refined and the results were compared with the findings of the fourth generation. The expert panel analyzed the RT planning and application of 1037 (28 %) patients (HD13 n = 465, HD14 n = 572). Simulation films were available in 85 % of cases and verification films in 87 %. RT was assessed as major violation in 46 % (HD13 = 38 %, HD14 = 52 %), minor violation in 9 % (HD13 = 9 %, HD14 = 9 %) and according to the protocol in 45 % (HD13 = 52 %, HD14 = 38 %). The value for QAP of RT within the GHSG trials is well known. Still there were several protocol violations. In the future, the QAP program has to be adapted to the requirements of ''modern RT'' in malignant lymphoma. (orig.) [German] Seit Gruendung der German Hodgkin Study Group (GHSG) im Jahr 1978 wurde ein zentrales Qualitaetssicherungsprogramm (QAP) der Radiotherapie (RT) etabliert, um die Qualitaet der RT sicherzustellen. Waehrend der fortlaufenden Studiengenerationen wurde dieses QAP kontinuierlich weiterentwickelt. In dieser Auswertung werden die Ergebnisse der fuenften Studiengeneration (HD13-15) praesentiert und mit frueheren Ergebnissen

Design of a polarized target made of pure HD: analysis and distillation of HD, resonant virtual Compton scattering on the nucleon at TJNAF; Developpement d'une cible polarisee de pur HD: analyse et distillation du HD, diffusion compton virtuelle resonante sur le nucleon a TJNAF

Energy Technology Data Exchange (ETDEWEB)

Bouchigny, S

2004-04-01

The first part describe my work on the frozen spin target project HYDILE. This target has to be made of very pure HD (Hydrogen Deuterium), better than 99.95%. However, commercial HD is never found with a concentration better than 98%. The goal was, then, to build an HD distillation facility which could produce pure HD. We describe, in this thesis, the design of the distillator and the implementation of a quadrupole mass spectrometer to monitor the HD purity during the distillation process. The second part of the thesis concerns the analysis taken at the electron accelerator facility TJNAF (Virginia, USA). We look at the electroproduction of Delta resonances involving Deep Virtual Compton Scattering (DeltaVCS). The interpretation of this reaction in terms of GPDs (Generalized Parton Distribution) can provide new insights to the nucleon structure. We focus on the measurement of the beam spin asymmetry which comes from the interference of the Bethe Heitler process with the DeltaVCS. (author)

Elemental abundance studies of CP stars. II. The silicon stars HD 133029 and HD 192913

CERN Document Server

López-García, Z

1999-01-01

For pt.1 see ibid., vol.107, no.2, p.353-63 (1994). Fine analyses of the silicon stars HD 133029 and HD 192913 are presented using ATLAS9 model atmospheres whose predictions fit the optical region spectrophotometry and H gamma profiles and have the same bulk metallicity as the deduced abundances. Both are very He poor stars. The light elements are mostly solar except for silicon, and all the heavier elements, except nickel in HD 133029 which is solar, are greatly overabundant. The iron peak elements are typically 10 times overabundant. SrYZr are of order of 100 times solar. The rare earths are 1000 or more times overabundant. Table 4 is is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/Abstract.html. (50 refs).

Nuclear Radiation Degradation Study on HD Camera Based on CMOS Image Sensor at Different Dose Rates.

Science.gov (United States)

Wang, Congzheng; Hu, Song; Gao, Chunming; Feng, Chang

2018-02-08

In this work, we irradiated a high-definition (HD) industrial camera based on a commercial-off-the-shelf (COTS) CMOS image sensor (CIS) with Cobalt-60 gamma-rays. All components of the camera under test were fabricated without radiation hardening, except for the lens. The irradiation experiments of the HD camera under biased conditions were carried out at 1.0, 10.0, 20.0, 50.0 and 100.0 Gy/h. During the experiment, we found that the tested camera showed a remarkable degradation after irradiation and differed in the dose rates. With the increase of dose rate, the same target images become brighter. Under the same dose rate, the radiation effect in bright area is lower than that in dark area. Under different dose rates, the higher the dose rate is, the worse the radiation effect will be in both bright and dark areas. And the standard deviations of bright and dark areas become greater. Furthermore, through the progressive degradation analysis of the captured image, experimental results demonstrate that the attenuation of signal to noise ratio (SNR) versus radiation time is not obvious at the same dose rate, and the degradation is more and more serious with increasing dose rate. Additionally, the decrease rate of SNR at 20.0, 50.0 and 100.0 Gy/h is far greater than that at 1.0 and 10.0 Gy/h. Even so, we confirm that the HD industrial camera is still working at 10.0 Gy/h during the 8 h of measurements, with a moderate decrease of the SNR (5 dB). The work is valuable and can provide suggestion for camera users in the radiation field.

A SEARCH FOR THE TRANSIT OF HD 168443b: IMPROVED ORBITAL PARAMETERS AND PHOTOMETRY

Energy Technology Data Exchange (ETDEWEB)

Pilyavsky, Genady; Mahadevan, Suvrath; Wright, Jason T.; Wang, Xuesong X. [Department of Astronomy and Astrophysics, Pennsylvania State University, 525 Davey Laboratory, University Park, PA 16802 (United States); Kane, Stephen R.; Ciardi, David R.; Dragomir, Diana; Von Braun, Kaspar [NASA Exoplanet Science Institute, Caltech, MS 100-22, 770 South Wilson Avenue, Pasadena, CA 91125 (United States); Howard, Andrew W. [Department of Astronomy, University of California, Berkeley, CA 94720 (United States); De Pree, Chris; Marlowe, Hannah [Department of Physics and Astronomy, Agnes Scott College, 141 East College Avenue, Decatur, GA 30030 (United States); Fischer, Debra [Department of Astronomy, Yale University, New Haven, CT 06511 (United States); Henry, Gregory W. [Center of Excellence in Information Systems, Tennessee State University, 3500 John A. Merritt Blvd., Box 9501, Nashville, TN 37209 (United States); Jensen, Eric L. N. [Department of Physics and Astronomy, Swarthmore College, Swarthmore, PA 19081 (United States); Laughlin, Gregory [UCO/Lick Observatory, University of California, Santa Cruz, CA 95064 (United States); Rabus, Markus, E-mail: gcp5017@psu.edu, E-mail: suvrath@astro.psu.edu [Departamento de Astonomia y Astrofisica, Pontificia Universidad Catolica de Chile, Casilla 306, Santiago 22 (Chile)

2011-12-20

The discovery of transiting planets around bright stars holds the potential to greatly enhance our understanding of planetary atmospheres. In this work we present the search for transits of HD 168443b, a massive planet orbiting the bright star HD 168443 (V = 6.92) with a period of 58.11 days. The high eccentricity of the planetary orbit (e = 0.53) significantly enhances the a priori transit probability beyond that expected for a circular orbit, making HD 168443 a candidate for our ongoing Transit Ephemeris Refinement and Monitoring Survey. Using additional radial velocities from Keck High Resolution Echelle Spectrometer, we refined the orbital parameters of this multi-planet system and derived a new transit ephemeris for HD 168443b. The reduced uncertainties in the transit window make a photometric transit search practicable. Photometric observations acquired during predicted transit windows were obtained on three nights. Cerro Tololo Inter-American Observatory 1.0 m photometry acquired on 2010 September 7 had the required precision to detect a transit but fell just outside of our final transit window. Nightly photometry from the T8 0.8 m automated photometric telescope at Fairborn Observatory, acquired over a span of 109 nights, demonstrates that HD 168443 is constant on a timescale of weeks. Higher-cadence photometry on 2011 April 28 and June 25 shows no evidence of a transit. We are able to rule out a non-grazing transit of HD 168443b.

A Search for the Transit of HD 168443b: Improved Orbital Parameters and Photometry

Science.gov (United States)

Pilyavsky, Genady; Mahadevan, Suvrath; Kane, Stephen R.; Howard, Andrew W.; Ciardi, David R.; de Pree, Chris; Dragomir, Diana; Fischer, Debra; Henry, Gregory W.; Jensen, Eric L. N.; Laughlin, Gregory; Marlowe, Hannah; Rabus, Markus; von Braun, Kaspar; Wright, Jason T.; Wang, Xuesong X.

2011-12-01

The discovery of transiting planets around bright stars holds the potential to greatly enhance our understanding of planetary atmospheres. In this work we present the search for transits of HD 168443b, a massive planet orbiting the bright star HD 168443 (V = 6.92) with a period of 58.11 days. The high eccentricity of the planetary orbit (e = 0.53) significantly enhances the a priori transit probability beyond that expected for a circular orbit, making HD 168443 a candidate for our ongoing Transit Ephemeris Refinement and Monitoring Survey. Using additional radial velocities from Keck High Resolution Echelle Spectrometer, we refined the orbital parameters of this multi-planet system and derived a new transit ephemeris for HD 168443b. The reduced uncertainties in the transit window make a photometric transit search practicable. Photometric observations acquired during predicted transit windows were obtained on three nights. Cerro Tololo Inter-American Observatory 1.0 m photometry acquired on 2010 September 7 had the required precision to detect a transit but fell just outside of our final transit window. Nightly photometry from the T8 0.8 m automated photometric telescope at Fairborn Observatory, acquired over a span of 109 nights, demonstrates that HD 168443 is constant on a timescale of weeks. Higher-cadence photometry on 2011 April 28 and June 25 shows no evidence of a transit. We are able to rule out a non-grazing transit of HD 168443b.

Radiofrequency/infrared double resonance spectroscopy of the HD+ ion

International Nuclear Information System (INIS)

Carrington, Alan; McNab, I.R.; Montgomerie, C.A.

1989-01-01

We describe a double resonance technique for obtaining radiofrequency spectra of the HD + ion in vibration-rotation levels close to the dissociation limit. Infrared transitions are driven by Doppler tuning an HD + ion beam into resonance with a carbon dioxide infrared laser, and are detected by measuring H + fragment ions produced by electric field dissociation of the upper vibration-rotation level. Radiofrequency transitions between nuclear hyperfine components of the lower vibration-rotation level are then detected through resonant increases in the H + fragment ion current. The high spectroscopic resolution obtained, and the ability to measure magnetic dipole hyperfine transitions, will enable the hyperfine constants to be determined accurately. (author)

MULTI-EPOCH OBSERVATIONS OF HD 69830: HIGH-RESOLUTION SPECTROSCOPY AND LIMITS TO VARIABILITY

Energy Technology Data Exchange (ETDEWEB)

Beichman, C. A.; Tanner, A. M.; Bryden, G.; Akeson, R. L.; Ciardi, D. R. [NASA Exoplanet Science Institute, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, 91125 (United States); Lisse, C. M. [Johns Hopkins University, Applied Physics Laboratory, Laurel, MD 20723 (United States); Boden, A. F. [Caltech Optical Observatories, California Institute of Technology, Pasadena, CA 91125 (United States); Dodson-Robinson, S. E.; Salyk, C. [University of Texas, Astronomy Department, Austin, TX 78712 (United States); Wyatt, M. C., E-mail: chas@pop.jpl.nasa.gov [Institute of Astronomy, University of Cambridge, Cambridge, CB3 0HA (United Kingdom)

2011-12-10

The main-sequence solar-type star HD 69830 has an unusually large amount of dusty debris orbiting close to three planets found via the radial velocity technique. In order to explore the dynamical interaction between the dust and planets, we have performed multi-epoch photometry and spectroscopy of the system over several orbits of the outer dust. We find no evidence for changes in either the dust amount or its composition, with upper limits of 5%-7% (1{sigma} per spectral element) on the variability of the dust spectrum over 1 year, 3.3% (1{sigma}) on the broadband disk emission over 4 years, and 33% (1{sigma}) on the broadband disk emission over 24 years. Detailed modeling of the spectrum of the emitting dust indicates that the dust is located outside of the orbits of the three planets and has a composition similar to main-belt, C-type asteroids in our solar system. Additionally, we find no evidence for a wide variety of gas species associated with the dust. Our new higher signal-to-noise spectra do not confirm our previously claimed detection of H{sub 2}O ice leading to a firm conclusion that the debris can be associated with the break-up of one or more C-type asteroids formed in the dry, inner regions of the protoplanetary disk of the HD 69830 system. The modeling of the spectral energy distribution and high spatial resolution observations in the mid-infrared are consistent with a {approx}1 AU location for the emitting material.

Further investigation of the role of HLA-DPB1 in adult Hodgkin's disease (HD) suggests an influence on susceptibility to different HD subtypes.

OpenAIRE

Taylor, G.M.; Gokhale, D.A.; Crowther, D.; Woll, P.J.; Harris, M.; Ryder, D.; Ayres, M.; Radford, J.A.

1999-01-01

It has been suggested in a number of studies that susceptibility to adult Hodgkin's disease (HD) is influenced by the HLA class II region, and specifically by alleles at the HLA-DPB1 locus. Since HD is diagnostically complex, it is not clear whether different HLA-DPB1 alleles confer susceptibility to different HD subtypes. To clarify this we have extended a previous study to type DPB1 alleles in 147 adult HD patients from a single centre. We have analysed patients with nodular sclerosing (NS)...

HD Photo: a new image coding technology for digital photography

Science.gov (United States)

Srinivasan, Sridhar; Tu, Chengjie; Regunathan, Shankar L.; Sullivan, Gary J.

2007-09-01

This paper introduces the HD Photo coding technology developed by Microsoft Corporation. The storage format for this technology is now under consideration in the ITU-T/ISO/IEC JPEG committee as a candidate for standardization under the name JPEG XR. The technology was developed to address end-to-end digital imaging application requirements, particularly including the needs of digital photography. HD Photo includes features such as good compression capability, high dynamic range support, high image quality capability, lossless coding support, full-format 4:4:4 color sampling, simple thumbnail extraction, embedded bitstream scalability of resolution and fidelity, and degradation-free compressed domain support of key manipulations such as cropping, flipping and rotation. HD Photo has been designed to optimize image quality and compression efficiency while also enabling low-complexity encoding and decoding implementations. To ensure low complexity for implementations, the design features have been incorporated in a way that not only minimizes the computational requirements of the individual components (including consideration of such aspects as memory footprint, cache effects, and parallelization opportunities) but results in a self-consistent design that maximizes the commonality of functional processing components.

Listeria monocytogenes infection of HD11, chicken macrophage-like cells.

Science.gov (United States)

Jarvis, N A; Donaldson, J R; O'Bryan, C A; Ricke, S C; Crandall, P G

2017-04-01

Listeria monocytogenes can be carried by and infect poultry, although the clinical disease in birds is rare. Escape from macrophage phagocytosis is a key step in pathogenesis for L. monocytogenes. Therefore, we investigated the infection of the chicken macrophage-like cell line HD11 with 2 strains of L. monocytogenes EGD-e and Scott A. After infection, L. monocytogenes was quantified by spread plating and HD11 was quantified with trypan blue exclusion stain before enumeration. The standard macrophage killing protocols require washing the cell monolayers 3 times with PBS, which was found to negatively influence HD11 monolayers. Maximum bacterial densities within macrophages were not different between the 2 Listeria strains. HD11 required more than 11 h to effectively reduce intracellular L. monocytogenes Scott A, and Scott A was more susceptible to HD11 killing than EGD-e. It appears that Listeria infection initially causes attenuation of HD11 growth, and infected HD11 cells do not begin to lyse until at least 11 h post infection. These results suggest that there are subtle strain to strain differences in response to HD11 macrophage phagocytosis. The long lead-time required for HD11 to kill L. monocytogenes cells means that there is sufficient time available for chicken macrophages to circulate in the blood and transfer the intracellular Listeria to multiple tissues. © 2016 Poultry Science Association Inc.

Game-based combined cognitive and neurofeedback training using Focus Pocus reduces symptom severity in children with diagnosed AD/HD and subclinical AD/HD.

Science.gov (United States)

Johnstone, Stuart J; Roodenrys, Steven J; Johnson, Kirsten; Bonfield, Rebecca; Bennett, Susan J

2017-06-01

Previous studies report reductions in symptom severity after combined working memory (WM) and inhibitory control (IC) training in children with AD/HD. Based on theoretical accounts of the role of arousal/attention modulation problems in AD/HD, the current study examined the efficacy of combined WM, IC, and neurofeedback training in children with AD/HD and subclinical AD/HD. Using a randomized waitlist control design, 85 children were randomly allocated to a training or waitlist condition and completed pre- and post-training assessments of overt behavior, trained and untrained cognitive task performance, and resting and task-related EEG activity. The training group completed twenty-five sessions of training using Focus Pocus software at home over a 7 to 8-week period. Trainees improved at the trained tasks, while enjoyment and engagement declined across sessions. After training, AD/HD symptom severity was reduced in the AD/HD and subclinical groups according to parents, and in the former group only according to blinded teachers and significant-others. There were minor improvements in two of six near-transfer tasks, and evidence of far-transfer of training effects in four of five far-transfer tasks. Frontal region changes indicated normalization of atypical EEG features with reduced delta and increased alpha activity. It is concluded that technology developments provide an interesting a vehicle for delivering interventions and that, while further research is needed, combined WM, IC, and neurofeedback training can reduce AD/HD symptom severity in children with AD/HD and may also be beneficial to children with subclinical AD/HD. Copyright © 2017 Elsevier B.V. All rights reserved.

The Concordance between Patients' Renal Replacement Therapy Choice and Definitive Modality: Is It a Utopia?

Science.gov (United States)

Prieto-Velasco, Mario; Quiros, Pedro; Remon, Cesar

2015-01-01

It is desirable for patients to play active roles in the choice of renal replacement therapy (RRT). Patient decision aid tools (PDAs) have been developed to allow the patients to choose the option best suited to their individual needs. An observational, prospective registry was conducted in 26 Spanish hospitals between September 2010 and May 2012. The results of the patients' choice and the definitive RRT modality were registered through the progressive implementation of an Education Process (EP) with PDAs designed to help Chronic Kidney Disease (CKD) patients choose RRT. Patients included in this study: 1044. Of these, 569 patients used PDAs and had made a definitive choice by the end of registration. A total of 88.4% of patients chose dialysis [43% hemodialysis (HD) and 45% peritoneal dialysis (PD)] 3.2% preemptive living-donor transplant (TX), and 8.4% conservative treatment (CT). A total of 399 patients began RRT during this period. The distribution was 93.4% dialysis (53.6% HD; 40% PD), 1.3% preemptive TX and 5.3% CT. The patients who followed the EP changed their mind significantly less often [kappa value of 0.91 (95% CI, 0.86-0.95)] than those who did not follow it, despite starting unplanned treatment [kappa value of 0.85 (95% CI, 0.75-0.95]. A higher agreement between the final choice and a definitive treatment was achieved by the EP and planned patients [kappa value of 0.93 (95% CI, 0.89-0.98)]. Those who did not go through the EP had a much lower index of choosing PD and changed their decision more frequently when starting definitive treatment [kappa value of 0.73 (95% CI, 0.55-0.91)]. Free choice, assisted by PDAs, leads to a 50/50 distribution of PD and HD choice and an increase in TX choice. The use of PDAs, even with an unplanned start, achieved a high level of concordance between the chosen and definitive modality.

Absolute parameters of southern detached eclipsing binary: HD 53570

Science.gov (United States)

Sürgit, D.

2018-05-01

In this study, we conducted the first analysis of spectroscopic and photometric observations of the eclipsing binary star HD 53570. Spectroscopic observations of HD 53570 were made at the Sutherland Station of the South African Astronomical Observatory in 2013 and 2014. The radial velocities of the components were determined using the cross-correlation technique. The spectroscopic mass ratio obtained for the system was 1.13 ( ± 0.07). The All Sky Automated Survey V light curve of HD 53570 was analyzed using the Wilson-Devinney code combined with the Monte Carlo search method. The final model showed that HD 53570 has a detached configuration. The mass and radii of the primary and secondary components of HD 53570 were derived as 1.06 ( ± 0.07) M⊙, 1.20 ( ± 0.16) M⊙, and 1.42 ( ± 0.14) R⊙, 2.07 ( ± 0.16) R⊙, respectively. The distance of HD 53570 was computed as 248 ( ± 38) pc considering interstellar extinction. The evolutionary status of the component stars was also investigated using Geneva evolutionary models.

Quality control of involved field radiotherapy in the HD 13 and HD 14 trials. Report of the radiotherapy panel of the German Hodgkin Study Group (GHSG)

International Nuclear Information System (INIS)

Kriz, J.; Haverkamp, U.; Eich, H.T.; Baues, C.; Engenhart-Cabillic, R.; Herfarth, K.; Lukas, P.; Pluetschow, A.; Fuchs, M.; Engert, A.; Schmidberger, H.; Staar, S.

2017-01-01

As part of the foundation of the German Hodgkin Study Group (GHSG) in 1978, a central radiotherapy (RT) reference centre was established to evaluate and to improve the quality of treatment. During the study generations, the quality assurance programs (QAP) were continued and adapted to the demands of each study. The purpose of this article is to demonstrate the results of the fifth study generation and to compare them to the previous findings. With the start of the fourth GHSG study generation (HD10-12), a central prospective review of all diagnostic images was established to create an individual treatment plan for each early stage study patient. The quality of involved field RT was retrospectively evaluated by an expert panel of radiation oncologists. In the fifth study generation (HD13-15), the retrospective review of radiotherapy performed was refined and the results were compared with the findings of the fourth generation. The expert panel analyzed the RT planning and application of 1037 (28 %) patients (HD13 n = 465, HD14 n = 572). Simulation films were available in 85 % of cases and verification films in 87 %. RT was assessed as major violation in 46 % (HD13 = 38 %, HD14 = 52 %), minor violation in 9 % (HD13 = 9 %, HD14 = 9 %) and according to the protocol in 45 % (HD13 = 52 %, HD14 = 38 %). The value for QAP of RT within the GHSG trials is well known. Still there were several protocol violations. In the future, the QAP program has to be adapted to the requirements of ''modern RT'' in malignant lymphoma. (orig.) [de

HD 285507b

DEFF Research Database (Denmark)

Quinn, Samuel N.; White, Russel J.; Latham, David W.

2014-01-01

We report the discovery of the first hot Jupiter in the Hyades open cluster. HD 285507b orbits a V = 10.47 K4.5V dwarf (M * = 0.734 M ☉; R * = 0.656 R ☉) in a slightly eccentric () orbit with a period of days. The induced stellar radial velocity corresponds to a minimum companion mass of M Psin i...... timescale for HD 285507b to be larger than the age of the Hyades, which may indicate that this planet's non-zero eccentricity is the result of migration via interactions with a third body. We also demonstrate a significant difference between the eccentricity distributions of hot Jupiters that have had time...... to tidally circularize and those that have not, which we interpret as evidence against Type II migration in the final stages of hot Jupiter formation. Finally, the dependence of the circularization timescale on the planetary tidal quality factor, Q P, allows us to constrain the average value for hot Jupiters to be ....

Nuclear Radiation Degradation Study on HD Camera Based on CMOS Image Sensor at Different Dose Rates

Directory of Open Access Journals (Sweden)

Congzheng Wang

2018-02-01

Full Text Available In this work, we irradiated a high-definition (HD industrial camera based on a commercial-off-the-shelf (COTS CMOS image sensor (CIS with Cobalt-60 gamma-rays. All components of the camera under test were fabricated without radiation hardening, except for the lens. The irradiation experiments of the HD camera under biased conditions were carried out at 1.0, 10.0, 20.0, 50.0 and 100.0 Gy/h. During the experiment, we found that the tested camera showed a remarkable degradation after irradiation and differed in the dose rates. With the increase of dose rate, the same target images become brighter. Under the same dose rate, the radiation effect in bright area is lower than that in dark area. Under different dose rates, the higher the dose rate is, the worse the radiation effect will be in both bright and dark areas. And the standard deviations of bright and dark areas become greater. Furthermore, through the progressive degradation analysis of the captured image, experimental results demonstrate that the attenuation of signal to noise ratio (SNR versus radiation time is not obvious at the same dose rate, and the degradation is more and more serious with increasing dose rate. Additionally, the decrease rate of SNR at 20.0, 50.0 and 100.0 Gy/h is far greater than that at 1.0 and 10.0 Gy/h. Even so, we confirm that the HD industrial camera is still working at 10.0 Gy/h during the 8 h of measurements, with a moderate decrease of the SNR (5 dB. The work is valuable and can provide suggestion for camera users in the radiation field.

ROVIBRATIONAL QUENCHING RATE COEFFICIENTS OF HD IN COLLISIONS WITH He

International Nuclear Information System (INIS)

Nolte, J. L.; Stancil, P. C.; Lee, T.-G.; Balakrishnan, N.; Forrey, R. C.

2012-01-01

Along with H 2 , HD has been found to play an important role in the cooling of the primordial gas for the formation of the first stars and galaxies. It has also been observed in a variety of cool molecular astrophysical environments. The rate of cooling by HD molecules requires knowledge of collisional rate coefficients with the primary impactors, H, He, and H 2 . To improve knowledge of the collisional properties of HD, we present rate coefficients for the He-HD collision system over a range of collision energies from 10 –5 to 5 × 10 3 cm –1 . Fully quantum mechanical scattering calculations were performed for initial HD rovibrational states of j = 0 and 1 for v = 0-17 which utilized accurate diatom rovibrational wave functions. Rate coefficients of all Δv = 0, –1, and –2 transitions are reported. Significant discrepancies with previous calculations, which adopted a small basis and harmonic HD wave functions for excited vibrational levels, were found for the highest previously considered vibrational state of v = 3. Applications of the He-HD rate coefficients in various astrophysical environments are briefly discussed.

Which Executive Functioning Deficits Are Associated with AD/HD, ODD/CD and Comorbid AD/HD+ODD/CD? (Attention Deficit/hyperactivity Disorder)(Oppositional Defiant Disorder)

Science.gov (United States)

Oosterlaan, Jaap; Scheres, Anouk; Sergeant, Joseph A.

2005-01-01

This study investigated (1) whether attention deficit/hyperactivity disorder (AD/HD) is associated with executive functioning (EF) deficits while controlling for oppositional defiant disorder/conduct disorder (ODD/CD), (2) whether ODD/CD is associated with EF deficits while controlling for AD/HD, and (3) whether a combination of AD/HD and ODD/CD…

No hydrogen exosphere detected around the super-Earth HD 97658 b

Science.gov (United States)

Bourrier, V.; Ehrenreich, D.; King, G.; Lecavelier des Etangs, A.; Wheatley, P. J.; Vidal-Madjar, A.; Pepe, F.; Udry, S.

2017-01-01

The exoplanet HD 97658 b provides a rare opportunity to probe the atmospheric composition and evolution of moderately irradiated super-Earths. It transits a bright K star at a moderate orbital distance of 0.08 au. Its low density is compatible with a massive steam envelope that could photodissociate at high altitudes and become observable as escaping neutral hydrogen. Our analysis of three transits with HST/STIS at Lyman-α reveals no such signature, suggesting that the thermosphere of HD 97658 b is not hydrodynamically expanding and is subjected to a low escape of neutral hydrogen (soft X-ray source with signs of chromospheric variability in the Lyman-α line core. We determine an average reference for the intrinsic Lyman-α line and X-EUV (XUV) spectrum of the star, and show that HD 97658 b is in mild conditions of irradiation compared to other known evaporating exoplanets with an XUV irradiation about three times lower than the evaporating warm Neptune GJ436 b. This could be the reason why the thermosphere of HD 97658 b is not expanding: the low XUV irradiation prevents an efficient photodissociation of any putative steam envelope. Alternatively, it could be linked to a low hydrogen content or inefficient conversion of the stellar energy input. The HD 97658 system provides clues for understanding the stability of low-mass planet atmospheres in terms of composition, planetary density, and irradiation. Our study of HD 97658 b can be seen as a control experiment of our methodology, confirming that it does not bias detections of atmospheric escape and underlining its strength and reliability. Our results show that stellar activity can be efficiently discriminated from absorption signatures by a transiting exospheric cloud. They also highlight the potential of observing the upper atmosphere of small transiting planets to probe their physical and chemical properties.

AtHD2D gene plays a role in plant growth, development and response to abiotic stresses in Arabidopsis thaliana

Directory of Open Access Journals (Sweden)

Zhaofen eHan

2016-03-01

Full Text Available Abstracts: The histone deacetylases play important roles in the regulation of gene expression and the subsequent control of a number of important biological processes, including those involved in the response to environmental stress. A specific group of histone deacetylase genes, HD2, is present in plants. In Arabidopsis, HD2s include HD2A, HD2B, HD2C and HD2D. Previous research showed that HD2A, HD2B and HD2C are more related in terms of expression and function, but not HD2D. In this report, we studied different aspects of AtHD2D in Arabidopsis with respect to plant response to drought and other abiotic stresses. Bioinformatics analysis indicates that HD2D is distantly related to other HD2 genes. Transient expression in Nicotiana benthamiana and stable expression in Arabidopsis of AtHD2D fused with gfp showed that AtHD2D was expressed in the nucleus. Overexpression of AtHD2D resulted in developmental changes including fewer main roots, more lateral roots, and a higher root:shoot ratio. Seed germination and plant flowering time were delayed in transgenic plants expressing AtHD2D, but these plants exhibited higher degrees of tolerance to abiotic stresses, including drought, salt and cold stresses. Physiological studies indicated that the malondialdehyde (MDA content was high in wild-type plants but in plants overexpressing HD2D the MDA level increased slowly in response to stress conditions of drought, cold, and salt stress. Furthermore, electrolyte leakage in leaf cells of wild type plants increased but remained stable in transgenic plants. Our results indicate that AtHD2D is unique among HD2 genes and it plays a role in plant growth and development regulation and these changes can modulate plant stress responses.

High definition versus standard definition white light endoscopy for detecting dysplasia in patients with Barrett's esophagus.

Science.gov (United States)

Sami, S S; Subramanian, V; Butt, W M; Bejkar, G; Coleman, J; Mannath, J; Ragunath, K

2015-01-01

High-definition endoscopy systems provide superior image resolution. The aim of this study was to assess the utility of high definition compared with standard definition endoscopy system for detecting dysplastic lesions in patients with Barrett's esophagus. A retrospective cohort study of patients with non-dysplastic Barrett's esophagus undergoing routine surveillance was performed. Data were retrieved from the central hospital electronic database. Procedures performed for non-surveillance indications, Barrett's esophagus Prague C0M1 classification with no specialized intestinal metaplasia on histology, patients diagnosed with any dysplasia or cancer on index endoscopy, and procedures using advanced imaging techniques were excluded. Logistic regression models were constructed to estimate adjusted odds ratios and 95% confidence intervals comparing outcomes with standard definition and high-definition systems. The high definition was superior to standard definition system in targeted detection of all dysplastic lesions (odds ratio 3.27, 95% confidence interval 1.27-8.40) as well as overall dysplasia detected on both random and target biopsies (odds ratio 2.36, 95% confidence interval 1.50-3.72). More non-dysplastic lesions were detected with the high-definition system (odds ratio 1.16, 95% confidence interval 1.01-1.33). There was no difference between high definition and standard definition endoscopy in the overall (random and target) high-grade dysplasia or cancers detected (odds ratio 0.93, 95% confidence interval 0.83-1.04). Trainee endoscopists, number of biopsies taken, and male sex were all significantly associated with a higher yield for dysplastic lesions. The use of the high-definition endoscopy system is associated with better targeted detection of any dysplasia during routine Barrett's esophagus surveillance. However, high-definition endoscopy cannot replace random biopsies at present time. © 2014 International Society for Diseases of the Esophagus.

Thermodynamics of dinonylnaphthalene sulfonic acid (HD)

International Nuclear Information System (INIS)

Raieh, M.A.; Aly, H.F.

1980-01-01

The effect of temperature on the extraction of the trivalent actinides Am 3+ , Cm 3+ and Cf 3+ with the liquid cation exchanger dinonylnaphtalenesulphonic acid (HD) in toluene is studied. The different thermodynamic functions of this system are determined from the experimental results. It is found that the free energy variation for the extraction of these metal ions by HD is mainly determined by the entropic terms arising from the hydration-dehydration process of the exchanged ions. (author)

Identification of Heading Date Six (Hd6 Gene Derived from Rice Mutant Varieties

Directory of Open Access Journals (Sweden)

Aryanti Aryanti

2017-04-01

Full Text Available Genes which were associated with flowering time to indicate the early maturity is known as heading date (Hd. Heading date six (Hd6 gene was identified from rice mutant varieties were Atomita 2, Atomita 3, Atomita 4, Bestari, Cilosari, Diah Suci, Sidenuk, Kahayan, Mayang, Meraoke, Mira-1, Pandan Putri, Superwin, Suluttan Unsrat 1, Suluttan Unsrat 2, Winongo, Woyla, Yuwono, while the rice var. Nipponbare was used as a positive control. All of rice mutant varieties derived from mutation induction by the dose of 0.2 kGy. The aim of this experiment was to find out the data base of mutant varieties which could be used as parent material with earlier maturity trait genetically. To obtain the DNA of plants, young leaves of each variety were extracted by liquid nitrogen, and then lysis and extracted by Kit Plant Genomic DNA. The amplification of DNA with 7 primers of Hd6 conducted of 40 cycles by PCR and were continues to separated by 1 % agarose. The results were shown that the rice Mira-1 and Bestari varieties obtained from mutation of Cisantana highly different from one to another on 7 primers of Hd6 used. Mayang variety from mutation of cross breeding between Cilosari and IR64, Pandan putri from Pandan wangi and Woyla from mutation of cross breeding from Atomita 2 and IR64 were highly different with those of their parents. Identification of Hd6 gene on Sidenuk variety was shown the same bands pattern with Nipponbare as control positive toward all primers used, this variety would be better for earlier maturity parent material compared to others. The information could be useful for breeding programs aiming to develop early maturing widely adaptive and high yielding rice cultivars.

HD 38452 - J. R. Hind's star that changed colour

Science.gov (United States)

Warner, Brian; Sneden, Christopher

1988-01-01

In 1851, John Russell Hind announced that a star previously observed by him to be very red had become bluish white in color. It is shown that this star, HD 38451, is a ninth magnitude shell star which presumably was ejecting a shell when Hind first observed it. From high dispersion coude spectra, low dispersion IUE spectra, and ground-based photometry, HD 38451 is found to be a normal A21V shell star. Its current values of E(B-V) of about 0.14 is probably caused by interstellar rather than circumstellar reddening. There remains a problem to reconcile the large amount of reddening present when Hind first observed the star with its evidently small diminution in visual brightness at that time.

HD 38451: J.R. Hind's star that changed colour

International Nuclear Information System (INIS)

Warner, B.; Cape Town Univ.; Snedon, C.

1988-01-01

In 1851, John Russell Hind announced that a star previously observed by him to be very red had become bluish white in colour. We show that this star, HD 38451, is a ninth magnitude shell star which presumably was ejecting a shell when Hind first observed it. From high dispersion coude spectra, low dispersion IUE spectra and ground-based photometry we find HD 38451 to be a normal A2IV shell star. Its current value of E(B-V) approx. ident to 0.14 is probably caused by interstellar rather than circumstellar reddening. There remains a problem to reconcile the large amount of reddening present when Hind first observed the star with its evidently small diminution in visual brightness at that time. (author)

HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain.

Directory of Open Access Journals (Sweden)

Marie-Claude Gingras

Full Text Available The HD-PTP protein has been described as a tumor suppressor candidate and based on its amino acid sequence, categorized as a classical non-transmembrane protein tyrosine phosphatase (PTP. To date, no HD-PTP phosphorylated substrate has been identified and controversial results concerning its catalytic activity have been recently reported.Here we report a rigorous enzymatic analysis demonstrating that the HD-PTP protein does not harbor tyrosine phosphatase or lipid phosphatase activity using the highly sensitive DiFMUP substrate and a panel of different phosphatidylinositol phosphates. We found that HD-PTP tyrosine phosphatase inactivity is caused by an evolutionary conserved amino acid divergence of a key residue located in the HD-PTP phosphatase domain since its back mutation is sufficient to restore the HD-PTP tyrosine phosphatase activity. Moreover, in agreement with a tumor suppressor activity, HD-PTP expression leads to colony growth reduction in human cancer cell lines, independently of its catalytic PTP activity status.In summary, we demonstrate that HD-PTP is a catalytically inactive protein tyrosine phosphatase. As such, we identify one residue involved in its inactivation and show that its colony growth reduction activity is independent of its PTP activity status in human cancer cell lines.

MID-INFRARED HIGH-CONTRAST IMAGING OF HD 114174 B: AN APPARENT AGE DISCREPANCY IN A ''SIRIUS-LIKE'' BINARY SYSTEM

Energy Technology Data Exchange (ETDEWEB)

Matthews, Christopher T.; Crepp, Justin R. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Skemer, Andrew; Hinz, Philip M.; Bailey, Vanessa P.; Defrere, Denis; Leisenring, Jarron [Department of Astronomy, University of Arizona, 993 N. Cherry Ave, Tucson, AZ 85721 (United States); Gianninas, Alexandros; Kilic, Mukremin [Department of Physics and Astronomy, University of Oklahoma, Norman, OK 73019 (United States); Skrutskie, Michael [Department of Astronomy, University of Virginia, Charlottesville, VA 22904 (United States); Esposito, Simone; Puglisi, Alfio [Istituto Nazionale di Astrofisica, Osservatorio Astrofisico di Arcetri Largo E. Fermi I-550125 Firenze (Italy)

2014-03-10

We present new observations of the faint ''Sirius-like'' companion discovered to orbit HD 114174. Previous attempts to image HD 114174 B at mid-infrared wavelengths using NIRC2 at Keck have resulted in a non-detection. Our new L'-band observations taken with the Large Binocular Telescope and L/M-band InfraRed Camera recover the companion (ΔL = 10.15 ± 0.15 mag, ρ = 0.''675 ± 0.''016) with a high signal-to-noise ratio (10σ). This measurement represents the deepest L' high-contrast imaging detection at subarcsecond separations to date, including extrasolar planets. We confirm that HD 114174 B has near-infrared colors consistent with the interpretation of a cool white dwarf (WD; J – L' = 0.76 ± 0.19 mag, K – L' = 0.64 ± 0.20). New model fits to the object's spectral energy distribution indicate a temperature T {sub eff} = 4260 ± 360 K, surface gravity log g = 7.94 ± 0.03, a cooling age t{sub c} ≈ 7.8 Gyr, and mass M = 0.54 ± 0.01 M {sub ☉}. We find that the cooling ages given by theoretical atmospheric models do not agree with the age of HD 114174 A derived from both isochronological and gyrochronological analyses. We speculate on possible scenarios to explain the apparent age discrepancy between the primary and secondary. HD 114174 B is a nearby benchmark WD that will ultimately enable a dynamical mass estimate through continued Doppler and astrometric monitoring. Efforts to characterize its physical properties in detail will test theoretical atmospheric models and improve our understanding of WD evolution, cooling, and progenitor masses.

Datablock: hd141

Indian Academy of Sciences (India)

2016-01-15

Jan 15, 2016 ... checkCIF/PLATON page 2 http://checkcif.iucr.org/cgibin/checkcif_hkl.pl. 1/3. checkCIF (basic structural check) running. checkCIF/PLATON (basic structural check). Structure factors have been supplied for datablock(s) hd141. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW.

High-definition endoscopy with iScan and Lugol's solution for the detection of inflammation in patients with nonerosive reflux disease: histologic evaluation in comparison with a control group.

Science.gov (United States)

Rey, J W; Deris, N; Marquardt, J U; Thomaidis, T; Moehler, M; Kittner, J M; Nguyen-Tat, M; Dümcke, S; Tresch, A; Biesterfeld, S; Goetz, M; Mudter, J; Neurath, M F; Galle, P R; Kiesslich, R; Hoffman, A

2016-01-01

Nonerosive reflux disease (NERD) is commonly diagnosed in patients with symptoms of reflux. The aim of the present study was to determine whether high-definition endoscopy (HD) plus equipped with the iScan function or chromoendoscopy with Lugol's solution might permit the differentiation of NERD patients from those without reflux symptoms, proven by targeted biopsies of endoscopic lesions. A total of 100 patients without regular intake of proton pump inhibitors and with a normal conventional upper endoscopy were prospectively divided into NERD patients and controls. A second upper endoscopy was performed using HD+ with additional iScan function and then Lugol's solution was applied. Biopsy specimens were taken from the gastroesophageal junction in all patients. A total of 65 patients with reflux symptoms and 27 controls were included. HD(+) endoscopy with iScan revealed subtle mucosal breaks in 52 patients; the subsequent biopsies confirmed esophagitis in all cases. After Lugol's solution, 58 patients showed mucosal breaks. Sensitivity for the iScan procedure was 82.5%, whereas that for Lugol's solution was 92.06%. Excellent positive predictive values of 100% and 98.3%, respectively, were noted. The present study suggests that the majority of patients with NERD and typical symptoms of reflux disease can be identified by iScan or Lugol's chromoendoscopy as minimal erosive reflux disease (ERD) patients. © 2014 International Society for Diseases of the Esophagus.

Acetone and Water on TiO(110): H/D Exchange

International Nuclear Information System (INIS)

Henderson, Michael A.

2005-01-01

Isotopic H/D exchange between coadsorbed acetone and water on the TiO(110) surface was examined using temperature programmed desorption (TPD) as a function of coverage and two surface pretreatments (oxidation and reduction). Coadsorbed acetone and water interact repulsively on reduced TiO(110) based on results from the companion paper to this study, with water exerting a greater influence in destabilizing acetone and acetone having only a nominal influence on water. Despite the repulsive interaction between these coadsorbates, about 0.02 ML of a 1 ML d6-acetone on the reduced surface exhibits H/D exchange with coadsorbed water, with the exchange occurring exclusively in the high temperature region of the d?-acetone TPD spectrum at ∼340 K. The effect was confirmed with combinations of d?-acetone and D?O. The extent of exchange decreased on the reduced surface with water coverages above ∼0.3 ML due to the ability of water to displace coadsorbed acetone from first layer sites to the multilayer. In contrast, the extent of exchange increased by a factor of 3 when the surface was pre-oxidized prior to coadsorption. In this case, there was no evidence for the negative influence of high water coverages on the extent of H/D exchange. Comparison of the TPD spectra from the exchange products (either d?- or d?-acetone depending on the coadsorption pairing) suggests that, in addition to the 340 K exchange process seen on the reduced surface, a second exchange process was observed on the oxidized surface at ∼390 K. In both cases (oxidized and reduced), desorption of the H/D exchange products appeared to be reaction limited and to involve the influence of OH/OD groups (or water formed during recombinative desorption of OH/OD groups) instead of molecularly adsorbed water. The 340 K exchange process is assigned to reaction at step sites and the 390 K exchange process is attributed to the influence of oxygen adatoms deposited during surface oxidation. The H/D exchange

Conformations of cationized linear oligosaccharides revealed by FTMS combined with in-ESI H/D exchange.

Science.gov (United States)

Kostyukevich, Yury; Kononikhin, Alexey; Popov, Igor; Nikolaev, Eugene

2015-10-01

Previously (Kostyukevich et al. Anal Chem 2014, 86, 2595), we have reported that oligosaccharides anions are produced in the electrospray in two different conformations, which differ by the rate of gas phase hydrogen/deuterium (H/D) exchange reaction. In the present paper, we apply the in-electrospray ionization (ESI) source H/D exchange approach for the investigation of the oligosaccharides cations formed by attaching of metal ions (Na, K) to the molecule. It was observed that the formation of different conformers can be manipulated by varying the temperature of the desolvating capillary of the ESI interphase. Separation of the conformers was performed using gas phase H/D approach. Because the conformers have different rates of the H/D exchange reaction, the deuterium distribution spectrum becomes bimodal. It was found that the conformation corresponding to the slow H/D exchange rate dominates in the spectrum when the capillary temperature is low (~200 °C), and the conformation corresponding to the fast H/D exchange rate dominates at high (~400 °C) temperatures. In the intermediate temperature region, two conformers are present simultaneously. It was also observed that large oligosaccharide requires higher temperature for the formation of another conformer. It was found that the presence of the conformers considerably depends on the solvent used for ESI and the pH. We have compared these results with the previously performed in-ESI source H/D exchange experiments with peptides and proteins. Copyright © 2015 John Wiley & Sons, Ltd.

Phenomena of g-u symmetry-breakdown in HD

NARCIS (Netherlands)

de Lange, A.; Reinhold, E.M.; Ubachs, W.M.G.

2002-01-01

Phenomena associated with the breakdown of inversion symmetry in the HD molecule are reviewed and discussed. A distinction is made between three kinds of physical effects observed in HD spectra. The existence of a small electric dipole moment in the ground state gives rise to vibrational and pure

Resolving the HD 100546 Protoplanetary System with the Gemini Planet Imager: Evidence for Multiple Forming, Accreting Planets

OpenAIRE

Currie, Thayne; Cloutier, Ryan; Brittain, Sean; Grady, Carol; Burrows, Adam; Muto, Takayuki; Kenyon, Scott J.; Kuchner, Marc J.

2015-01-01

We report Gemini Planet Imager H band high-contrast imaging/integral field spectroscopy and polarimetry of the HD 100546, a 10 $Myr$-old early-type star recently confirmed to host a thermal infrared bright (super)jovian protoplanet at wide separation, HD 100546 b. We resolve the inner disk cavity in polarized light, recover the thermal-infrared (IR) bright arm, and identify one additional spiral arm. We easily recover HD 100546 b and show that much of its emission originates an unresolved, po...

Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: a decade of the PREDICT-HD study

Directory of Open Access Journals (Sweden)

Jane S Paulsen

2014-04-01

Full Text Available There is growing consensus that intervention and treatment of Huntington disease (HD should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinical trials for HD are limited by a lack of knowledge of the natural history of the disease and a dearth of appropriate outcome measures. Objectives of the current study are to document the natural history of premanifest HD progression in the largest cohort ever studied and to develop a battery of imaging and clinical markers of premanifest HD progression that can be used as outcome measures in preventive clinical trials. PREDICT-HD is a 32-site, international, observational study of premanifest HD, with annual examination of 1013 participants with premanifest HD and 301 gene-expansion negative controls between 2001 and 2012. Findings document 39 variables representing imaging, motor, cognitive, functional, and psychiatric domains, showing different rates of decline between premanifest Huntington disease and controls. Required sample size and models of premanifest HD are presented to inform future design of clinical and preclinical research. Preventive clinical trials in premanifest HD with participants who have a medium or high probability of motor onset are calculated to be as resource-effective as those conducted in diagnosed HD and could interrupt disease seven to twelve years earlier. Methods and measures for preventive clinical trials in premanifest HD more than a dozen years from motor onset are also feasible. These findings represent the most thorough documentation of a clinical battery for experimental therapeutics in stages of premanifest HD, the time period for which effective intervention may provide the most positive possible outcome for patients and their families affected by this devastating disease.

Fusion with highly spin polarized HD and D2

International Nuclear Information System (INIS)

Honig, A.; Letzring, S.; Skupsky, S.

1993-01-01

The experimental efforts over the past 5 years have been aimed at carrying out ICF shots with spin-polarized D fuel. The authors successfully prepared polarized D in HD, and solved the problems of loading target shells with their carefully prepared isotopic mixtures, polarizing them so that the D polarization remains metastably frozen-in for about half a day, and carrying out the various cold transfer requirements at Syracuse, where the target is prepared, and at Rochester, where the cold target is inserted into the OMEGA fusion chamber. A principal concern during this past year was overcoming difficulties encountered in maintaining the integrity of the fragile cold target during the multitude of cold-transfers required for the experiment. These difficulties arose from insufficient rigidity of the cold transfer systems, which were constrained to be of small diameter by the narrow central access bore of the dilution refrigerator, and were exacerbated by the multitude of required target shell manipulations between different environments, each with different coupling geometry, including target shell permeation, polarization, storage, transport, retrieval and insertion into OMEGA. The authors did solve all of these problems, and were able to position a cold, high density but unpolarized target with required precision in OMEGA. Upon shooting the accurately positioned unpolarized high density cold target, no neutron yield was observed. Inspection inside the OMEGA tank after the shot indicated the absence of neutron yield was due to mal-timing or insufficient retraction rate of OMEGA's fast shroud mechanism, resulting in interception of at least 20 of the 24 laser beams by the faulty shroud. In spite of this, all elements of the complex experiment the authors originally undertook have been successfully demonstrated, and the cold retrieval concepts and methods they developed are being utilized on the ICF upgrades at Rochester and at Livermore

Mitochondrial fragmentation in neuronal degeneration: Toward an understanding of HD striatal susceptibility

International Nuclear Information System (INIS)

Cherubini, Marta; Ginés, Silvia

2017-01-01

Huntington's disease (HD) is an autosomal-dominant progressive neurodegenerative disorder that primarily affects medium spiny neurons within the striatum. HD is caused by inheritance of an expanded CAG repeat in the HTT gene, resulting in a mutant huntingtin (mHtt) protein containing extra glutamine residues. Despite the advances in understanding the molecular mechanisms involved in HD the preferential vulnerability of the striatum remains an intriguing question. This review discusses current knowledge that links altered mitochondrial dynamics with striatal susceptibility in HD. We also highlight how the modulation of mitochondrial function may constitute an attractive therapeutic approach to reduce mHtt-induced toxicity and therefore prevent the selective striatal neurodegeneration. - Highlights: • Mitochondrial dynamics is unbalanced towards fission in HD. • Excessive mitochondrial fragmentation plays a critical role in the selective vulnerability of the striatum in HD. • Therapeutic approaches aimed to inhibit mitochondrial fission could contribute to prevent striatal neurodegeneration in HD.

Computer-aided detection of early cancer in the esophagus using HD endoscopy images

Science.gov (United States)

van der Sommen, Fons; Zinger, Svitlana; Schoon, Erik J.; de With, Peter H. N.

2013-02-01

Esophageal cancer is the fastest rising type of cancer in the Western world. The recent development of High-Definition (HD) endoscopy has enabled the specialist physician to identify cancer at an early stage. Nevertheless, it still requires considerable effort and training to be able to recognize these irregularities associated with early cancer. As a first step towards a Computer-Aided Detection (CAD) system that supports the physician in finding these early stages of cancer, we propose an algorithm that is able to identify irregularities in the esophagus automatically, based on HD endoscopic images. The concept employs tile-based processing, so our system is not only able to identify that an endoscopic image contains early cancer, but it can also locate it. The identification is based on the following steps: (1) preprocessing, (2) feature extraction with dimensionality reduction, (3) classification. We evaluate the detection performance in RGB, HSI and YCbCr color space using the Color Histogram (CH) and Gabor features and we compare with other well-known features to describe texture. For classification, we employ a Support Vector Machine (SVM) and evaluate its performance using different parameters and kernel functions. In experiments, our system achieves a classification accuracy of 95.9% on 50×50 pixel tiles of tumorous and normal tissue and reaches an Area Under the Curve (AUC) of 0.990. In 22 clinical examples our algorithm was able to identify all (pre-)cancerous regions and annotate those regions reasonably well. The experimental and clinical validation are considered promising for a CAD system that supports the physician in finding early stage cancer.

NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity

Directory of Open Access Journals (Sweden)

Wei-Jan Huang

2012-01-01

Full Text Available HDAC inhibitors (HDACis have been developed as promising anticancer agents in recent years. In this study, we synthesized and characterized a novel HDACi, termed NBM-HD-1. This agent was derived from the semisynthesis of propolin G, isolated from Taiwanese green propolis (TGP, and was shown to be a potent suppressor of tumor cell growth in human breast cancer cells (MCF-7 and MDA-MB-231 and rat glioma cells (C6, with an IC50 ranging from 8.5 to 10.3 μM. Western blot demonstrated that levels of p21(Waf1/Cip1, gelsolin, Ac-histone 4, and Ac-tubulin markedly increased after treatment of cancer cells with NBM-HD-1. After NBM-HD-1 treatment for 1–4 h, p-PTEN and p-AKT levels were markedly decreased. Furthermore, we also found the anticancer activities of NBM-HD-1 in regulating cell cycle regulators. Treatment with NBM-HD-1, p21(Waf1/Cip1 gene expression had markedly increased while cyclin B1 and D1 gene expressions had markedly decreased. On the other hand, we found that NBM-HD-1 increased the expressions of tumor-suppressor gene p53 in a dose-dependent manner. Finally, we showed that NBM-HD-1 exhibited potent antitumor activity in a xenograft model. In conclusion, this study demonstrated that this compound, NBM-HD-1, is a novel and potent HDACi with anticancer activity in vitro and in vivo.

Positive evolutionary selection of an HD motif on Alzheimer precursor protein orthologues suggests a functional role.

Science.gov (United States)

Miklós, István; Zádori, Zoltán

2012-02-01

HD amino acid duplex has been found in the active center of many different enzymes. The dyad plays remarkably different roles in their catalytic processes that usually involve metal coordination. An HD motif is positioned directly on the amyloid beta fragment (Aβ) and on the carboxy-terminal region of the extracellular domain (CAED) of the human amyloid precursor protein (APP) and a taxonomically well defined group of APP orthologues (APPOs). In human Aβ HD is part of a presumed, RGD-like integrin-binding motif RHD; however, neither RHD nor RXD demonstrates reasonable conservation in APPOs. The sequences of CAEDs and the position of the HD are not particularly conserved either, yet we show with a novel statistical method using evolutionary modeling that the presence of HD on CAEDs cannot be the result of neutral evolutionary forces (pHD motif is underrepresented in the proteomes of all species of the animal kingdom. Position migration can be explained by high probability occurrence of multiple copies of HD on intermediate sequences, from which only one is kept by selective evolutionary forces, in a similar way as in the case of the "transcription binding site turnover." CAED of all APP orthologues and homologues are predicted to bind metal ions including Amyloid-like protein 1 (APLP1) and Amyloid-like protein 2 (APLP2). Our results suggest that HDs on the CAEDs are most probably key components of metal-binding domains, which facilitate and/or regulate inter- or intra-molecular interactions in a metal ion-dependent or metal ion concentration-dependent manner. The involvement of naturally occurring mutations of HD (Tottori (D7N) and English (H6R) mutations) in early onset Alzheimer's disease gives additional support to our finding that HD has an evolutionary preserved function on APPOs.

Analysis of spectra of V471 Tau and HD 115404

Science.gov (United States)

Shimansky, V. V.; Bikmaev, I. F.; Shimanskaya, N. N.

2011-10-01

We analyze the chemical composition of the atmospheres of a single K-type star HD 115404 and the secondary component of the V471 Tau variable. We use the technique of modeling of synthetic spectra to analyze the high-resolution spectra of these stars, taken with the RTT 150 Russian-Turkish telescope and find the abundances of 23 and 17 elements in the atmospheres of HD 115404 and V471 Tau, respectively. We demonstrate the lack of composition anomalies in the HD 115404 and show it to be consistent with the published data, inferred from equivalent widths of spectral lines. We find the abundances of 15 elements from Na to Ba to be consistent with the metallicity of the atmosphere of V471 Tau ([Fe/H] = -0.22 ± 0.12dex), which differs significantly from the average metallicity of the Hyades cluster. We show the existence of strong carbon and oxygen overabundances (by more than 1dex) due to the enrichment of the secondary by the nucleosynthesis products during the common-envelope stage of the system. On the whole, we demonstrate that V471 Tau and the other precataclysmic variables share similar composition anomalies.

Preface [HD3-2015: International meeting on high-dimensional data-driven science

International Nuclear Information System (INIS)

2016-01-01

A never-ending series of innovations in measurement technology and evolutions in information and communication technologies have led to the ongoing generation and accumulation of large quantities of high-dimensional data every day. While detailed data-centric approaches have been pursued in respective research fields, situations have been encountered where the same mathematical framework of high-dimensional data analysis can be found in a wide variety of seemingly unrelated research fields, such as estimation on the basis of undersampled Fourier transform in nuclear magnetic resonance spectroscopy in chemistry, in magnetic resonance imaging in medicine, and in astronomical interferometry in astronomy. In such situations, bringing diverse viewpoints together therefore becomes a driving force for the creation of innovative developments in various different research fields. This meeting focuses on “Sparse Modeling” (SpM) as a methodology for creation of innovative developments through the incorporation of a wide variety of viewpoints in various research fields. The objective of this meeting is to offer a forum where researchers with interest in SpM can assemble and exchange information on the latest results and newly established methodologies, and discuss future directions of the interdisciplinary studies for High-Dimensional Data-Driven science (HD 3 ). The meeting was held in Kyoto from 14-17 December 2015. We are pleased to publish 22 papers contributed by invited speakers in this volume of Journal of Physics: Conference Series. We hope that this volume will promote further development of High-Dimensional Data-Driven science. (paper)

The Mass of the Candidate Exoplanet Companion to HD 33636 from Hubble Space Telescope Astrometry and High-Precision Radial Velocities

Science.gov (United States)

Bean, Jacob L.; McArthur, Barbara E.; Benedict, G. Fritz; Harrison, Thomas E.; Bizyaev, Dmitry; Nelan, Edmund; Smith, Verne V.

2007-08-01

We have determined a dynamical mass for the companion to HD 33636 that indicates it is a low-mass star instead of an exoplanet. Our result is based on an analysis of Hubble Space Telescope (HST) astrometry and ground-based radial velocity data. We have obtained high-cadence radial velocity measurements spanning 1.3 yr of HD 33636 with the Hobby-Eberly Telescope at McDonald Observatory. We combined these data with previously published velocities to create a data set that spans 9 yr. We used this data set to search for, and place mass limits on, the existence of additional companions in the HD 33636 system. Our high-precision astrometric observations of the system with the HST Fine Guidance Sensor 1r span 1.2 yr. We simultaneously modeled the radial velocity and astrometry data to determine the parallax, proper motion, and perturbation orbit parameters of HD 33636. Our derived parallax, πabs=35.6+/-0.2 mas, agrees within the uncertainties with the Hipparcos value. We find a perturbation period P=2117.3+/-0.8 days, semimajor axis aA=14.2+/-0.2 mas, and system inclination i=4.1deg+/-0.1deg. Assuming the mass of the primary star to be MA=1.02+/-0.03 Msolar, we obtain a companion mass MB=142+/-11 MJup=0.14+/-0.01 Msolar. The much larger true mass of the companion relative to its minimum mass estimated from the spectroscopic orbit parameters (Msini=9.3 MJup) is due to the nearly face-on orbit orientation. This result demonstrates the value of follow-up astrometric observations to determine the true masses of exoplanet candidates detected with the radial velocity method. Based on data obtained with the NASA/ESA Hubble Space Telescope (HST) and the Hobby-Eberly Telescope (HET). The HST observations were obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. The HET is a joint project of the University of Texas at Austin, Pennsylvania State University, Stanford

Quality of Life in Prodromal HD: Qualitative Analyses of Discourse from Participants and Companions

Directory of Open Access Journals (Sweden)

Rebecca E. Ready

2011-01-01

Full Text Available Persons who are at risk for Huntington's Disease (HD can be tested for the HD gene expansion before symptom onset. People with the gene expansion, but no clinical diagnosis, are in the prodromal phase of HD. This study explored quality of life (QOL in prodromal HD. Interviews about QOL, conducted with 9 prodromal HD participants and 6 companions, were transcribed. Discourse was coded for emotional valence, content (e.g., coping, spirituality, interpersonal relationships, HD in others, and employment, and time frame (e.g., current, past, and future. Respondents were more positive than negative about the present, which was their major focus. The most common statements were about positive attitudes. Positive statements were made about spirituality, and negative statements were made about HD in other people. Relationships, employment, and coping with HD reflected both positivity and negativity. Participants and companions spoke of the future with different concerns. Applicability of findings to the clinical management of HD are discussed.

DYNAMICAL MASS OF THE SUBSTELLAR BENCHMARK BINARY HD 130948BC , ,

International Nuclear Information System (INIS)

Dupuy, Trent J.; Liu, Michael C.; Ireland, Michael J.

2009-01-01

We present Keck adaptive optics imaging of the L4+L4 binary HD 130948BC along with archival Hubble Space Telescope and Gemini North observations, which together span ∼ 70% of the binary's orbital period. From the relative orbit, we determine a total dynamical mass of 0.109 ± 0.003 M sun (114 ± 3 M Jup ). The flux ratio of HD 130948BC is near unity, so both components are unambiguously substellar for any plausible mass ratio. An independent constraint on the age of the system is available from the primary HD 130948A (G2V, [M/H] = 0.0). The ensemble of available indicators suggests an age comparable to Hyades, with the most precise age being 0.79 +0.22 -0.15 Gyr based on gyrochronology. Therefore, HD 130948BC is now a unique benchmark among field L and T dwarfs, with a well-determined mass, luminosity, and age. We find that substellar theoretical models disagree with our observations. (1) Both components of HD 130948BC appear to be overluminous by a factor of ∼ 2-3 times compared to evolutionary models. The age of the system would have to be notably younger than the gyro age to ameliorate the luminosity disagreement. (2) Effective temperatures derived from evolutionary models for HD 130948B and C are inconsistent with temperatures determined from spectral synthesis for objects of similar spectral type. Overall, regardless of the adopted age, evolutionary and atmospheric models give inconsistent results, which indicate systematic errors in at least one class of models, possibly both. The masses of HD 130948BC happen to be very near the theoretical mass limit for lithium burning, and thus measuring the differential lithium depletion between B and C will provide a uniquely discriminating test of theoretical models. The potential underestimate of luminosities by evolutionary models would have wide-ranging implications; therefore, a more refined estimate age for HD 130948A is critically needed.

High-definition optical coherence tomography imaging of melanocytic lesions

DEFF Research Database (Denmark)

Boone, Marc A L M; Norrenberg, Sarah; Jemec, Gregor B E

2014-01-01

and cytologic features of melanocytic lesions. All lesions were examined by one observer clinically and using dermoscopy. Cross-sectional HD-OCT images were compared with histopathology. En face HD-OCT images were compared with reflectance confocal microscopy (RCM). Twenty-six melanocytic lesions of 26 patients...... with sufficient resolution and penetration depth to discriminate architectural patterns and cytologic features of pigmented cells in epidermis and dermis. The method appears to offer the possibility of additional three-dimensional structural information complementary to that of RCM, albeit at a slightly lower...

BD+15 2940 AND HD 233604: TWO GIANTS WITH PLANETS CLOSE TO THE ENGULFMENT ZONE

International Nuclear Information System (INIS)

Nowak, G.; Niedzielski, A.; Adamów, M.; Maciejewski, G.; Wolszczan, A.

2013-01-01

We report the discovery of planetary-mass companions to two red giants by the ongoing Penn State-Toruń Planet Search (PTPS) conducted with the 9.2 m Hobby-Eberly Telescope. The 1.1 M ☉ K0-giant, BD+15 2940, has a 1.1 M J minimum mass companion orbiting the star at a 137.5 day period in a 0.54 AU orbit what makes it the closest—in planet around a giant and possible subject of engulfment as the consequence of stellar evolution. HD 233604, a 1.5 M ☉ K5-giant, is orbited by a 6.6 M J minimum mass planet which has a period of 192 days and a semi-major axis of only 0.75 AU making it one of the least distant planets to a giant star. The chemical composition analysis of HD 233604 reveals a relatively high 7 Li abundance which may be a sign of its early evolutionary stage or recent engulfment of another planet in the system. We also present independent detections of planetary-mass companions to HD 209458 and HD 88133, and stellar activity-induced radial velocity variations in HD 166435, as part of the discussion of the observing and data analysis methods used in the PTPS project.

Disagreement between theory and experiment grows with increasing rotational excitation of HD(v', j') product for the H + D2 reaction.

Science.gov (United States)

Jankunas, Justin; Sneha, Mahima; Zare, Richard N; Bouakline, Foudhil; Althorpe, Stuart C

2013-03-07

The Photoloc technique has been employed to measure the state-resolved differential cross sections of the HD(v', j(')) product in the reaction H + D2 over a wide range of collision energies and internal states. The experimental results were compared with fully dimensional, time-dependent quantum mechanical calculations on the refined Boothroyd-Keogh-Martin-Peterson potential energy surface. We find nearly perfect agreement between theory and experiment for HD(v', j(')) product states with low to medium rotational excitation, e.g., HD(v' = 1, j(') = 3) at a collision energy, Ecoll, of 1.72 eV, HD(v' = 1, j(') = 3, 5) at Ecoll = 1.97 eV, and HD(v' = 3, j(') = 3) at Ecoll = 1.97 eV. As the rotational angular momentum, j('), of HD(v', j(')) increases, the agreement between theoretical predictions and experimental measurements worsens but not in a simple fashion. A moderate disagreement between theory and experiment has been found for HD(v' = 0, j(') = 12) at Ecoll = 1.76 eV and increased monotonically for HD(v' = 0, j(') = 13) at Ecoll = 1.74 eV, HD(v' = 0, j(') = 14) at Ecoll = 1.72 eV, and HD(v' = 0, j(') = 15) at Ecoll = 1.70 eV. Disagreement was not limited to vibrationless HD(v', j(')) product states: HD(v' = 1, j(') = 12) at Ecoll = 1.60 eV and HD(v' = 3, j(') = 8, 10) at Ecoll = 1.97 eV followed a similar trend. Theoretical calculations suggest more sideways∕forward scattering than has been observed experimentally for high j(') HD(v', j(')) states. The source of this discrepancy is presently unknown but might be the result of inaccuracy in the potential energy surface.

High Definition Video Streaming Using H.264 Video Compression

OpenAIRE

Bechqito, Yassine

2009-01-01

This thesis presents high definition video streaming using H.264 codec implementation. The experiment carried out in this study was done for an offline streaming video but a model for live high definition streaming is introduced, as well. Prior to the actual experiment, this study describes digital media streaming. Also, the different technologies involved in video streaming are covered. These include streaming architecture and a brief overview on H.264 codec as well as high definition t...

4K Video Traffic Prediction using Seasonal Autoregressive Modeling

Directory of Open Access Journals (Sweden)

D. R. Marković

2017-06-01

Full Text Available From the perspective of average viewer, high definition video streams such as HD (High Definition and UHD (Ultra HD are increasing their internet presence year over year. This is not surprising, having in mind expansion of HD streaming services, such as YouTube, Netflix etc. Therefore, high definition video streams are starting to challenge network resource allocation with their bandwidth requirements and statistical characteristics. Need for analysis and modeling of this demanding video traffic has essential importance for better quality of service and experience support. In this paper we use an easy-to-apply statistical model for prediction of 4K video traffic. Namely, seasonal autoregressive modeling is applied in prediction of 4K video traffic, encoded with HEVC (High Efficiency Video Coding. Analysis and modeling were performed within R programming environment using over 17.000 high definition video frames. It is shown that the proposed methodology provides good accuracy in high definition video traffic modeling.

Baseband Transceiver Design of a High Definition Radio FM System Using Joint Theoretical Analysis and FPGA Implementation

Directory of Open Access Journals (Sweden)

Chien-Sheng Chen

2014-01-01

Full Text Available Advances in wireless communications have enabled various technologies for wireless digital communication. In the field of digital radio broadcasting, several specifications have been proposed, such as Eureka-147 and digital radio mondiale (DRM. These systems require a new spectrum assignment, which incurs heavy cost due to the depletion of the available spectrum. Therefore, the in-band on-channel (IBOC system has been developed to work in the same band with the conventional analog radio and to provide digital broadcasting services. This paper discusses the function and algorithm of the high definition (HD radio frequency modulation (FM digital radio broadcasting system. Content includes data format allocation, constellation mapping, orthogonal frequency division multiplexing (OFDM modulation of the transmitter, timing synchronization, OFDM demodulation, integer and fraction carrier frequency (integer carrier frequency offset (ICFO and fractional CFO (FCFO estimation, and channel estimation of the receiver. When we implement this system to the field programmable gate array (FPGA based on a hardware platform, both theoretical and practical aspects have been considered to accommodate the available hardware resources.

A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins

International Nuclear Information System (INIS)

Cao Qinhong; Chen Jie; Zhu Li; Liu Yun; Zhou Zuomin; Sha Jiahao; Wang Shui; Li Jianmin

2006-01-01

Tumor protein D52-like proteins (TPD52) are small coiled-coil motif bearing proteins that were first identified in breast cancer. TPD52 and related proteins have been implicated in cell proliferation, apoptosis, and vesicle trafficking. To date, three human TPD52 members had been identified, named hD52 (TPD52), hD53 (TPD52L1), and hD54 (TPD52L2). The most important characteristic of the protein family is a highly conserved coiled-coil motif that is required for homo- and heteromeric interaction with other TPD52-like proteins. Herein, we identified a novel TPD52-like sequence (TPD52L3, or hD55) in human testis using cDNA microarray. Sequence analysis of the deduced protein suggests that hD55 contains a coiled-coil motif and is highly conserved compared with other TPD52-like sequences. Yeast two-hybrid and GST pull-down assays revealed that hD55 interacts with hD52, hD53, hD54, and itself. cDNA microarray detection found that hD55 was expressed at 5.6-fold higher levels in adult testis than in fetal testis. Additionally, the expression profile shows that hD55 is testis-specific, indicating a potential role for hD55 in testis development and spermatogenesis

High-cadence, High-resolution Spectroscopic Observations of Herbig Stars HD 98922 and V1295 Aquila

Energy Technology Data Exchange (ETDEWEB)

Aarnio, Alicia N.; Monnier, John D.; Calvet, Nuria; Che, Xiao [Department of Astronomy, University of Michigan, 311 West Hall, 1085 S. University Avenue, Ann Arbor, MI 48109 (United States); Harries, Tim J.; Kraus, Stefan; Acreman, David [Department of Physics and Astronomy, University of Exeter, Stocker Road, Exeter EX4 4QL (United Kingdom)

2017-10-10

Recent observational work has indicated that mechanisms for accretion and outflow in Herbig Ae/Be star–disk systems may differ from magnetospheric accretion (MA) as it is thought to occur in T Tauri star–disk systems. In this work, we assess the temporal evolution of spectral lines probing accretion and mass loss in Herbig Ae/Be systems and test for consistency with the MA paradigm. For two Herbig Ae/Be stars, HD 98922 (B9e) and V1295 Aql (A2e), we have gathered multi-epoch (∼years) and high-cadence (∼minutes) high-resolution optical spectra to probe a wide range of kinematic processes. Employing a line equivalent width evolution correlation metric introduced here, we identify species co-evolving (indicative of common line origin) via novel visualization. We interferometrically constrain often problematically degenerate parameters, inclination and inner-disk radius, allowing us to focus on the structure of the wind, magnetosphere, and inner gaseous disk in radiative transfer models. Over all timescales sampled, the strongest variability occurs within the blueshifted absorption components of the Balmer series lines; the strength of variability increases with the cadence of the observations. Finally, high-resolution spectra allow us to probe substructure within the Balmer series’ blueshifted absorption components: we observe static, low-velocity features and time-evolving features at higher velocities. Overall, we find the observed line morphologies and variability are inconsistent with a scaled-up T Tauri MA scenario. We suggest that as magnetic field structure and strength change dramatically with increasing stellar mass from T Tauri to Herbig Ae/Be stars, so too may accretion and outflow processes.

High-cadence, High-resolution Spectroscopic Observations of Herbig Stars HD 98922 and V1295 Aquila

International Nuclear Information System (INIS)

Aarnio, Alicia N.; Monnier, John D.; Calvet, Nuria; Che, Xiao; Harries, Tim J.; Kraus, Stefan; Acreman, David

2017-01-01

Recent observational work has indicated that mechanisms for accretion and outflow in Herbig Ae/Be star–disk systems may differ from magnetospheric accretion (MA) as it is thought to occur in T Tauri star–disk systems. In this work, we assess the temporal evolution of spectral lines probing accretion and mass loss in Herbig Ae/Be systems and test for consistency with the MA paradigm. For two Herbig Ae/Be stars, HD 98922 (B9e) and V1295 Aql (A2e), we have gathered multi-epoch (∼years) and high-cadence (∼minutes) high-resolution optical spectra to probe a wide range of kinematic processes. Employing a line equivalent width evolution correlation metric introduced here, we identify species co-evolving (indicative of common line origin) via novel visualization. We interferometrically constrain often problematically degenerate parameters, inclination and inner-disk radius, allowing us to focus on the structure of the wind, magnetosphere, and inner gaseous disk in radiative transfer models. Over all timescales sampled, the strongest variability occurs within the blueshifted absorption components of the Balmer series lines; the strength of variability increases with the cadence of the observations. Finally, high-resolution spectra allow us to probe substructure within the Balmer series’ blueshifted absorption components: we observe static, low-velocity features and time-evolving features at higher velocities. Overall, we find the observed line morphologies and variability are inconsistent with a scaled-up T Tauri MA scenario. We suggest that as magnetic field structure and strength change dramatically with increasing stellar mass from T Tauri to Herbig Ae/Be stars, so too may accretion and outflow processes.

Cutaneous Uptake of 14C-HD Vapor by the Hairless Guinea Pig.

Science.gov (United States)

1996-10-01

guinea pig (HGP) is used by our laboratory to model the human cutaneous response to sulfur mustard (HD) exposure. We have determined the HD content in the skin of HOP after 7-minute exposures to vapors saturated with a mixture of HD and 14C-HD. Concentration/time (C1) values in the range of 2 mg/sq cm/min were determined by counting skin 14C disintegrations per minute (dpm) in animals euthanized immediately after exposure. These values are similar to human penetration rates obtained by other investigators. A direct relationship between C1 and relative humidity was

Low latency adaptive streaming of HD H.264 video over 802.11 wireless networks with cross-layer feedback

Science.gov (United States)

Patti, Andrew; Tan, Wai-tian; Shen, Bo

2007-09-01

Streaming video in consumer homes over wireless IEEE 802.11 networks is becoming commonplace. Wireless 802.11 networks pose unique difficulties for streaming high definition (HD), low latency video due to their error-prone physical layer and media access procedures which were not designed for real-time traffic. HD video streaming, even with sophisticated H.264 encoding, is particularly challenging due to the large number of packet fragments per slice. Cross-layer design strategies have been proposed to address the issues of video streaming over 802.11. These designs increase streaming robustness by imposing some degree of monitoring and control over 802.11 parameters from application level, or by making the 802.11 layer media-aware. Important contributions are made, but none of the existing approaches directly take the 802.11 queuing into account. In this paper we take a different approach and propose a cross-layer design allowing direct, expedient control over the wireless packet queue, while obtaining timely feedback on transmission status for each packet in a media flow. This method can be fully implemented on a media sender with no explicit support or changes required to the media client. We assume that due to congestion or deteriorating signal-to-noise levels, the available throughput may drop substantially for extended periods of time, and thus propose video source adaptation methods that allow matching the bit-rate to available throughput. A particular H.264 slice encoding is presented to enable seamless stream switching between streams at multiple bit-rates, and we explore using new computationally efficient transcoding methods when only a high bit-rate stream is available.

Flattening filter free beams from TrueBeam and Versa HD units: Evaluation of the parameters for quality assurance

Energy Technology Data Exchange (ETDEWEB)

Fogliata, Antonella, E-mail: antonella.fogliata@humanitas.it; Reggiori, Giacomo; Stravato, Antonella; Scorsetti, Marta; Cozzi, Luca [Radiotherapy and Radiosurgery Department, Humanitas Research Hospital, Milan-Rozzano I-20098 (Italy); Fleckenstein, Jens; Schneider, Frank; Lohr, Frank [Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim D-68167 (Germany); Pachoud, Marc; Ghandour, Sarah [Radiation Oncology Department, Hôpital Riviera Chablais, Vevey CH-1800 (Switzerland); Krauss, Harald [Radio-Oncology Department, Kaiser Franz Josef Spital, Vienna A-1100 (Austria)

2016-01-15

Purpose: Flattening filter free (FFF) beams generated by medical linear accelerators are today clinically used for stereotactical and non-stereotactical radiotherapy treatments. Such beams differ from the standard flattened beams (FF) in the high dose rate and the profile shape peaked on the beam central axis. Definition of new parameters as unflatness and slope for FFF beams has been proposed based on a renormalization factor for FFF profiles. The present study aims to assess the dosimetric differences between FFF beams generated by linear accelerators from different vendors, and to provide renormalization and parameter data of the two kinds of units. Methods: Dosimetric data from two Varian TrueBeam and two Elekta Versa HD linear accelerators, all with 6 and 10 MV nominal accelerating potentials, FF and FFF modes have been collected. Renormalization factors and related fit parameters according to Fogliata et al. [“Definition of parameters for quality assurance of flattening filter free (FFF) photon beams in radiation therapy,” Med. Phys. 39, 6455–6464 (2012)] have been evaluated for FFF beams of both units and energies. Unflatness and slope parameters from profile curves were evaluated. Dosimetric differences in terms of beam penetration and near-the-surface dose were also assessed. Results: FFF profile parameters have been updated; renormalization factors and unflatness from the Varian units are consistent with the published data. Elekta FFF beam qualities, different from the Varian generated beams, tend to express similar behaviour as the FF beam of the corresponding nominal energy. TPR{sub 20,10} for 6 and 10 MV FF and FFF TrueBeam beams are 0.665, 0.629 (6 MV) and 0.738, 0.703 (10 MV). The same figures for Versa HD units are 0.684, 0.678 (6 MV) and 0.734, 0.721 (10 MV). Conclusions: Renormalization factor and unflatness parameters evaluated from Varian and Elekta FFF beams are provided, in particular renormalization factors table and fit parameters.

Catalytically important amino-acid residues of abalone alginate lyase HdAly assessed by site-directed mutagenesis

OpenAIRE

Yamamoto, Sayo; Sahara, Takehiko; Sato, Daisuke; Kawasaki, Kosei; Ohgiya, Satoru; Inoue, Akira; Ojima, Takao

2008-01-01

Alginate lyase is an enzyme that degrades alginate chains via β-elimination and has been used for the production of alginate oligosaccharides and protoplasts from brown algae. Previously, we deduced the amino-acid sequence of an abalone alginate lyase, HdAly, from its cDNA sequence and, through multiple amino-acid sequence alignment, found that several basic amino-acid residues were highly conserved among the polysaccharide-lyase family 14 (PL-14) enzymes including HdAly. In the present study...

THE PECULIAR DEBRIS DISK OF HD 111520 AS RESOLVED BY THE GEMINI PLANET IMAGER

Energy Technology Data Exchange (ETDEWEB)

Draper, Zachary H.; Matthews, Brenda C.; Gerard, Benjamin [Department of Physics and Astronomy, University of Victoria, 3800 Finnerty Rd., Victoria, BC V8P 5C2 (Canada); Duchêne, Gaspard; Wang, Jason J.; Kalas, Paul; Graham, James R. [Department of Astronomy, UC Berkeley, Berkeley, CA 94720 (United States); Millar-Blanchaer, Maxwell A. [Department of Astronomy and Astrophysics, University of Toronto, Toronto, ON M5S 3H4 (Canada); Padgett, Deborah [NASA Goddard Space Flight Center, 8800 Greenbelt Rd., Greenbelt, MD 20771 (United States); Ammons, S. Mark [Lawrence Livermore National Lab, 7000 East Ave., Livermore, CA 94551 (United States); Bulger, Joanna [Subaru Telescope, NAOJ, 650 North Aohoku Pl., Hilo, HI 96720 (United States); Chen, Christine; Greenbaum, Alexandra Z. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Chilcote, Jeffrey K. [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George St., Toronto, ON M5S 3H4 (Canada); Doyon, René [Institut de Recherche sur les Exoplanètes, Départment de Physique, Université de Montréal, Montréal, QC H3C 3J7 (Canada); Fitzgerald, Michael P. [Department of Physics and Astronomy, UCLA, Los Angeles, CA 90095 (United States); Follette, Kate B.; Macintosh, Bruce [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, Stanford, CA 94305 (United States); Hibon, Pascale [European Southern Observatory, Casilla 19001, Santiago 19 (Chile); Hinkley, Sasha [University of Exeter, Astrophysics Group, Physics Building, Stocker Rd., Exeter, EX4 4QL (United Kingdom); and others

2016-08-01

Using the Gemini Planet Imager, we have resolved the circumstellar debris disk around HD 111520 at a projected range of ∼30–100 AU in both total and polarized H -band intensity. The disk is seen edge-on at a position angle of 165° along the spine of emission. A slight inclination and asymmetric warp are covariant and alter the interpretation of the observed disk emission. We employ three point-spread function subtraction methods to reduce the stellar glare and instrumental artifacts to confirm that there is a roughly 2:1 brightness asymmetry between the NW and SE extension. This specific feature makes HD 111520 the most extreme example of asymmetric debris disks observed in scattered light among similar highly inclined systems, such as HD 15115 and HD 106906. We further identify a tentative localized brightness enhancement and scale height enhancement associated with the disk at ∼40 AU away from the star on the SE extension. We also find that the fractional polarization rises from 10% to 40% from 0.″5 to 0.″8 from the star. The combination of large brightness asymmetry and symmetric polarization fraction leads us to believe that an azimuthal dust density variation is causing the observed asymmetry.

Elemental abundances of the field horizontal-branch stars HD 86986, 130095 and 202759

International Nuclear Information System (INIS)

Adelman, S.J.

1990-01-01

Fine analyses of limited spectral regions of the field horizontal-branch A Stars HD86986, 130095 and 202759 confirm that these stars have abundances typical of Population II stars. HD 86986 has a metallicity of about 1/200 solar while HD 130095 and 202759 are even more metal poor. (author)

Introduction and feasibility study of the HD-270 MLC

International Nuclear Information System (INIS)

Kim, Dae Young; Kim Won Taek; Lee, Hwa Jung; Lee, Kang Hyeok

2003-01-01

The multileaf collimator(MLC) has many advantages, but use of the MLC increased effective penumbra and isodose undulation in dose distribution compared with that of an alloy block. In this work, we introduced the HD-270 MLC, which can improve the above disadvantages of MLC, and reported its feasibility study. The HD-270 MLC is a technique which combines the use of the existing Siemens multileaf collimator(3D MLC) with patient translation perpendicular to the leaf plane. The technique produces a smoothed isodose distribution with the reduced isodose undulation and effective penumbra. To assess the efficacy of the HD-270 technique and determine the appropriate resolution, a polygonal shaped MLC field was made to produce field edge angles from 0 degree to 75 degree with a step of 15 degree. Each HD-270 group was generated according to the allowed resolution, i. e., 5, 3, and 2 mm. The experiment was carried out on Primus, a Siemens linear accelerator configured with HD-270 MLC. The total 60 MU of 6 MV photon beam was delivered to X-Omat film (Kodak, USA) at a SAD of 100 cm and 1.5 cm depth in solid water phantom. Exposed films were scanned by Lumiscan75(LUMISYS) and analyzed using RIT113 software (Radiological Imaging Technology Inc., USA). To test the mechanical accuracy of table movement, the transverse, longitudinal, and vertical positions were controlled by a consol with ±5 mm, ±4 mm, ±3 mm, and ±2 mm steps, and then measured using a dial gauge with an accuracy of 0.001 inch. During the experiments, the table loaded with about 50 Kg human phantom to simulate the real treatment situation. The effective penumbra and isodose undulation became larger with increase the resolution and field edge angle. The accuracy of the table movement on each direction is good within the ±1 mm. Clinical use of the MLC can be increased by using of the HD-270 MLC which complements to the disadvantages of the MLC.

THE McDONALD OBSERVATORY PLANET SEARCH: NEW LONG-PERIOD GIANT PLANETS AND TWO INTERACTING JUPITERS IN THE HD 155358 SYSTEM

International Nuclear Information System (INIS)

Robertson, Paul; Endl, Michael; Cochran, William D.; MacQueen, Phillip J.; Brugamyer, Erik J.; Barnes, Stuart I.; Caldwell, Caroline; Wittenmyer, Robert A.; Horner, J.; Simon, Attila E.

2012-01-01

We present high-precision radial velocity (RV) observations of four solar-type (F7-G5) stars—HD 79498, HD 155358, HD 197037, and HD 220773—taken as part of the McDonald Observatory Planet Search Program. For each of these stars, we see evidence of Keplerian motion caused by the presence of one or more gas giant planets in long-period orbits. We derive orbital parameters for each system and note the properties (composition, activity, etc.) of the host stars. While we have previously announced the two-gas-giant HD 155358 system, we now report a shorter period for planet c. This new period is consistent with the planets being trapped in mutual 2:1 mean-motion resonance. We therefore perform an in-depth stability analysis, placing additional constraints on the orbital parameters of the planets. These results demonstrate the excellent long-term RV stability of the spectrometers on both the Harlan J. Smith 2.7 m telescope and the Hobby-Eberly telescope.

Light variations of the population II F-type supergiant HD 46703

Science.gov (United States)

Bond, H. E.; Carney, B. W.; Grauer, A. D.

1984-01-01

Photometric monitoring has revealed brightness variations of 0.1 m on a time scale of weeks for HD 46703, a metal-deficient F-type field analog of the stars lying above the horizontal branch in globular clusters. It is suggested that HD 46703 belongs to the '89 Her' class of luminous F-type variables. Since HD 46703 is unquestionably a halo object, it is almost certainly a low-mass star. It is suggested that it, and probably the other 89 Her variables, are masquerading as supergiants during their final evolution off the asymptotic giant branch.

Bidirectional uncompressed HD video distribution over fiber employing VCSELs

DEFF Research Database (Denmark)

Estaran Tolosa, Jose Manuel; Vegas Olmos, Juan José; Rodes, G. A.

2012-01-01

We report on a bidirectional system in which VCSELs are simultaneously modulated with two uncompressed HD video signals. The results show a large power budget and a negligible penalty over 10 km long transmission links.......We report on a bidirectional system in which VCSELs are simultaneously modulated with two uncompressed HD video signals. The results show a large power budget and a negligible penalty over 10 km long transmission links....

Maternal Emotions and Self-Efficacy Beliefs in Relation to Boys and Girls with AD/HD

Science.gov (United States)

Maniadaki, Katerina; Sonuga-Barke, Edmund; Kakouros, Efthymios; Karaba, Rania

2005-01-01

This study examined the impact of child gender on mothers' emotional responses to AD/HD, self-efficacy beliefs and perceived severity of AD/HD. Mothers (N = 118) of pre-schoolers were presented with a vignette describing a typical boy or girl with AD/HD and then completed three scales relating to their emotional response to AD/HD behaviour, their…

Subfoveal choroidal thickness measured by Cirrus HD optical coherence tomography in myopia

Directory of Open Access Journals (Sweden)

Li-Li Chen

2014-09-01

Full Text Available ATM: To measure the subfoveal choroidal thickness(SFCTin myopia using Cirrus HD optical coherence tomography(OCT, and to explore the relationship between the SFCT, axial length and myopic refractive spherical equivalent.METHODS: One-hundred thirty-three eyes of 70 healthy volunteers were recruited, and were divided into emmetropia group, low-degree myopia, middle-degree myopia and high-degree myopia group. SFCT were measured by Cirrus HD OCT, and the relationship between the SFCT, axial length and myopic refractive spherical equivalent were evaluated.RESULTS: 1Average SFCT was(275.91±55.74μm in normals, that in emmetropia group, low-degree myopia, middle-degree myopia and high-degree myopia group were(290.03±34.82μm,(287.64±51.51μm,(274.95±56.83μm,(248.37±67.98μm; 2the SFCT of high-degree myopia group was significant thinner than that of emmetropia group(PPPCONCLUSION: the SFCT is inversely correlated with increasing axial length and myopic refractive error.

Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases

Directory of Open Access Journals (Sweden)

Wernicke Caroline M

2011-08-01

Full Text Available Abstract Severe acute graft versus host disease (GvHD is a life-threatening complication after allogeneic hematopoietic stem cell transplantation. Human mesenchymal stromal cells (MSCs play an important role in endogenous tissue repair and possess strong immune-modulatory properties making them a promising tool for the treatment of steroid-refractory GvHD. To date, a few reports exist on the use of MSCs in treatment of GvHD in children indicating that children tend to respond better than adults, albeit with heterogeneous results. We here present a review of the literature and the clinical course of two instructive pediatric patients with acute steroid-refractory GvHD after haploidentical stem cell transplantation, which exemplify the beneficial effects of third-party transplanted MSCs in treatment of acute steroid-refractory GvHD. Moreover, we provide a meta-analysis of clinical studies addressing the outcome of patients with steroid-refractory GvHD and treatment with MSCs in adults and in children (n = 183; 122 adults, 61 children. Our meta-analysis demonstrates that the overall response-rate is high (73.8% and confirms, for the first time, that children indeed respond better to treatment of GvHD with MSCs than adults (complete response 57.4% vs. 45.1%, respectively. These data emphasize the significance of this therapeutic approach especially in children and indicate that future prospective studies are needed to assess the reasons for the observed differential response-rates in pediatric and adult patients.

Isolation and expression analysis of four HD-ZIP III family genes targeted by microRNA166 in peach.

Science.gov (United States)

Zhang, C H; Zhang, B B; Ma, R J; Yu, M L; Guo, S L; Guo, L

2015-10-30

MicroRNA166 (miR166) is known to have highly conserved targets that encode proteins of the class III homeodomain-leucine zipper (HD-ZIP III) family, in a broad range of plant species. To further understand the relationship between HD-ZIP III genes and miR166, four HD-ZIP III family genes (PpHB14, PpHB15, PpHB8, and PpREV) were isolated from peach (Prunus persica) tissue and characterized. Spatio-temporal expression profiles of the genes were analyzed. Genes of the peach HD-ZIP III family were predicted to encode five conserved domains. Deduced amino acid sequences and tertiary structures of the four peach HD-ZIP III genes were highly conserved, with corresponding genes in Arabidopsis thaliana. The expression level of four targets displayed the opposite trend to that of miR166 throughout fruit development, with the exception of PpHB14 from 35 to 55 days after full bloom (DAFB). This finding indicates that miR166 may negatively regulate its four targets throughout fruit development. As for leaf and phloem, the same trend in expression level was observed between four targets and miR166 from 75 to 105 DAFB. However, the opposite trend was observed for the transcript level between four targets and miR166 from 35 to 55 DAFB. miRNA166 may negatively regulate four targets in some but not all developmental stages for a given tissue. The four genes studied were observed to have, exactly or generally, the same change tendency as individual tissue development, a finding that suggests genes of the HD-ZIP III family in peach may have complementary or cooperative functions in various tissues.

HDAC4-Myogenin Axis As an Important Marker of HD-Related Skeletal Muscle Atrophy

Science.gov (United States)

Smeets, Cleo J. L. M.; Franklin, Sophie A.; Bondulich, Marie K.; Jolinon, Nelly; Muller, Thomas; Ahmed, Mhoriam; Dick, James R. T.; Piotrowska, Izabela; Greensmith, Linda; Smolenski, Ryszard T.; Bates, Gillian P.

2015-01-01

Skeletal muscle remodelling and contractile dysfunction occur through both acute and chronic disease processes. These include the accumulation of insoluble aggregates of misfolded amyloid proteins that is a pathological feature of Huntington’s disease (HD). While HD has been described primarily as a neurological disease, HD patients’ exhibit pronounced skeletal muscle atrophy. Given that huntingtin is a ubiquitously expressed protein, skeletal muscle fibres may be at risk of a cell autonomous HD-related dysfunction. However the mechanism leading to skeletal muscle abnormalities in the clinical and pre-clinical HD settings remains unknown. To unravel this mechanism, we employed the R6/2 transgenic and HdhQ150 knock-in mouse models of HD. We found that symptomatic animals developed a progressive impairment of the contractile characteristics of the hind limb muscles tibialis anterior (TA) and extensor digitorum longus (EDL), accompanied by a significant loss of motor units in the EDL. In symptomatic animals, these pronounced functional changes were accompanied by an aberrant deregulation of contractile protein transcripts and their up-stream transcriptional regulators. In addition, HD mouse models develop a significant reduction in muscle force, possibly as a result of a deterioration in energy metabolism and decreased oxidation that is accompanied by the re-expression of the HDAC4-DACH2-myogenin axis. These results show that muscle dysfunction is a key pathological feature of HD. PMID:25748626

Three Super-Earths Orbiting HD 7924

Science.gov (United States)

Fulton, Benjamin J.; Weiss, Lauren M.; Sinukoff, Evan; Isaacson, Howard; Howard, Andrew W.; Marcy, Geoffrey W.; Henry, Gregory W.; Holden, Bradford P.; Kibrick, Robert I.

2015-06-01

We report the discovery of two super-Earth-mass planets orbiting the nearby K0.5 dwarf HD 7924, which was previously known to host one small planet. The new companions have masses of 7.9 and 6.4 {{M}\\oplus }, and orbital periods of 15.3 and 24.5 days. We perform a joint analysis of high-precision radial velocity data from Keck/HIRES and the new Automated Planet Finder Telescope (APF) to robustly detect three total planets in the system. We refine the ephemeris of the previously known planet using 5 yr of new Keck data and high-cadence observations over the last 1.3 yr with the APF. With this new ephemeris, we show that a previous transit search for the inner-most planet would have covered 70% of the predicted ingress or egress times. Photometric data collected over the last eight years using the Automated Photometric Telescope shows no evidence for transits of any of the planets, which would be detectable if the planets transit and their compositions are hydrogen-dominated. We detect a long-period signal that we interpret as the stellar magnetic activity cycle since it is strongly correlated with the Ca ii H and K activity index. We also detect two additional short-period signals that we attribute to rotationally modulated starspots and a one-month alias. The high-cadence APF data help to distinguish between the true orbital periods and aliases caused by the window function of the Keck data. The planets orbiting HD 7924 are a local example of the compact, multi-planet systems that the Kepler Mission found in great abundance. Based on observations obtained at the W. M. Keck Observatory, which is operated jointly by the University of California and the California Institute of Technology. Keck time was granted for this project by the University of Hawai‘i, the University of California, and NASA.

Genome-wide analysis of the homeodomain-leucine zipper (HD-ZIP) gene family in peach (Prunus persica).

Science.gov (United States)

Zhang, C H; Ma, R J; Shen, Z J; Sun, X; Korir, N K; Yu, M L

2014-04-08

In this study, 33 homeodomain-leucine zipper (HD-ZIP) genes were identified in peach using the HD-ZIP amino acid sequences of Arabidopsis thaliana as a probe. Based on the phylogenetic analysis and the individual gene or protein characteristics, the HD-ZIP gene family in peach can be classified into 4 subfamilies, HD-ZIP I, II, III, and IV, containing 14, 7, 4, and 8 members, respectively. The most closely related peach HD-ZIP members within the same subfamilies shared very similar gene structure in terms of either intron/exon numbers or lengths. Almost all members of the same subfamily shared common motif compositions, thereby implying that the HD-ZIP proteins within the same subfamily may have functional similarity. The 33 peach HD-ZIP genes were distributed across scaffolds 1 to 7. Although the primary structure varied among HD-ZIP family proteins, their tertiary structures were similar. The results from this study will be useful in selecting candidate genes from specific subfamilies for functional analysis.

Virtually transparent epidermal imagery (VTEI): on new approaches to in vivo wireless high-definition video and image processing.

Science.gov (United States)

Anderson, Adam L; Lin, Bingxiong; Sun, Yu

2013-12-01

This work first overviews a novel design, and prototype implementation, of a virtually transparent epidermal imagery (VTEI) system for laparo-endoscopic single-site (LESS) surgery. The system uses a network of multiple, micro-cameras and multiview mosaicking to obtain a panoramic view of the surgery area. The prototype VTEI system also projects the generated panoramic view on the abdomen area to create a transparent display effect that mimics equivalent, but higher risk, open-cavity surgeries. The specific research focus of this paper is on two important aspects of a VTEI system: 1) in vivo wireless high-definition (HD) video transmission and 2) multi-image processing-both of which play key roles in next-generation systems. For transmission and reception, this paper proposes a theoretical wireless communication scheme for high-definition video in situations that require extremely small-footprint image sensors and in zero-latency applications. In such situations the typical optimized metrics in communication schemes, such as power and data rate, are far less important than latency and hardware footprint that absolutely preclude their use if not satisfied. This work proposes the use of a novel Frequency-Modulated Voltage-Division Multiplexing (FM-VDM) scheme where sensor data is kept analog and transmitted via "voltage-multiplexed" signals that are also frequency-modulated. Once images are received, a novel Homographic Image Mosaicking and Morphing (HIMM) algorithm is proposed to stitch images from respective cameras, that also compensates for irregular surfaces in real-time, into a single cohesive view of the surgical area. In VTEI, this view is then visible to the surgeon directly on the patient to give an "open cavity" feel to laparoscopic procedures.

The comparison of high and standard definition computed ...

African Journals Online (AJOL)

Material and methods: 28 patients with history of coronary artery disease scanned by HDCT (Discovery CT750 HD) and ... The radiation dose of HDCT was higher than that of SDCT. The mean ..... Because it is hard to find both devices in the.

HD 12098 and Other Results from Nainital–Cape Survey V. Girish

Indian Academy of Sciences (India)

Strömgren colours (δm1) of HD 12098, the first roAp star discovered under the ... 2, we can see an unresolved frequency very close to the alias peak (marked ... Figure 3. Lightcurve of HD 25499 observed on the night of 10th November 2003.

RESOLVING THE HD 100546 PROTOPLANETARY SYSTEM WITH THE GEMINI PLANET IMAGER: EVIDENCE FOR MULTIPLE FORMING, ACCRETING PLANETS

Energy Technology Data Exchange (ETDEWEB)

Currie, Thayne [National Astronomical Observatory of Japan, Subaru Telescope (Japan); Cloutier, Ryan [Department of Astronomy and Astrophysics, University of Toronto, Toronto, ON (Canada); Brittain, Sean [Department of Physics and Astronomy, Clemson University, Clemson, SC (United States); Grady, Carol; Kuchner, Marc J. [Exoplanets and Stellar Astrophysics Laboratory, NASA Goddard Space Flight Center, Greenbelt, MD (United States); Burrows, Adam [Department of Astrophysics Sciences, Princeton University, Princeton, NJ (United States); Muto, Takayuki [Division of Liberal Arts, Kogakuin University, Tokyo (Japan); Kenyon, Scott J. [Smithsonian Astrophysical Observatory, Cambridge, MA (United States)

2015-12-01

We report Gemini Planet Imager H-band high-contrast imaging/integral field spectroscopy and polarimetry of the HD 100546, a 10 Myr old early-type star recently confirmed to host a thermal infrared (IR) bright (super-)Jovian protoplanet at wide separation, HD 100546 b. We resolve the inner disk cavity in polarized light, recover the thermal IR-bright arm, and identify one additional spiral arm. We easily recover HD 100546 b and show that much of its emission plausibly originates from an unresolved point source. The point-source component of HD 100546 b has extremely red IR colors compared to field brown dwarfs, qualitatively similar to young cloudy super-Jovian planets; however, these colors may instead indicate that HD 100546 b is still accreting material from a circumplanetary disk. Additionally, we identify a second point-source-like peak at r{sub proj} ∼ 14 AU, located just interior to or at the inner disk wall consistent with being a <10–20 M{sub J} candidate second protoplanet—“HD 100546 c”—and lying within a weakly polarized region of the disk but along an extension of the thermal IR-bright spiral arm. Alternatively, it is equally plausible that this feature is a weakly polarized but locally bright region of the inner disk wall. Astrometric monitoring of this feature over the next 2 years and emission line measurements could confirm its status as a protoplanet, rotating disk hot spot that is possibly a signpost of a protoplanet, or a stationary emission source from within the disk.

RESOLVING THE HD 100546 PROTOPLANETARY SYSTEM WITH THE GEMINI PLANET IMAGER: EVIDENCE FOR MULTIPLE FORMING, ACCRETING PLANETS

International Nuclear Information System (INIS)

Currie, Thayne; Cloutier, Ryan; Brittain, Sean; Grady, Carol; Kuchner, Marc J.; Burrows, Adam; Muto, Takayuki; Kenyon, Scott J.

2015-01-01

We report Gemini Planet Imager H-band high-contrast imaging/integral field spectroscopy and polarimetry of the HD 100546, a 10 Myr old early-type star recently confirmed to host a thermal infrared (IR) bright (super-)Jovian protoplanet at wide separation, HD 100546 b. We resolve the inner disk cavity in polarized light, recover the thermal IR-bright arm, and identify one additional spiral arm. We easily recover HD 100546 b and show that much of its emission plausibly originates from an unresolved point source. The point-source component of HD 100546 b has extremely red IR colors compared to field brown dwarfs, qualitatively similar to young cloudy super-Jovian planets; however, these colors may instead indicate that HD 100546 b is still accreting material from a circumplanetary disk. Additionally, we identify a second point-source-like peak at r proj ∼ 14 AU, located just interior to or at the inner disk wall consistent with being a <10–20 M J candidate second protoplanet—“HD 100546 c”—and lying within a weakly polarized region of the disk but along an extension of the thermal IR-bright spiral arm. Alternatively, it is equally plausible that this feature is a weakly polarized but locally bright region of the inner disk wall. Astrometric monitoring of this feature over the next 2 years and emission line measurements could confirm its status as a protoplanet, rotating disk hot spot that is possibly a signpost of a protoplanet, or a stationary emission source from within the disk

Low-frequency photospheric and wind variability in the early-B supergiant HD2905

DEFF Research Database (Denmark)

Simon-Diaz, S.; Aerts, C.; Urbaneja, M. A.

2018-01-01

to the lack of adequate observations for a proper characterization of the complex spectroscopic and photometric variability occurring in these stars. Aims. Our goal is to detect, analyze, and interpret variability in the early-B-type supergiant HD2905 (kappa Cas, B1 Ia) using long-term, ground-based, high...... snapshot and time-dependent information about the stellar parameters and abundances by means of the FASTWIND stellar atmosphere code. Results. HD2905 is a spectroscopic variable with peak-to-peak amplitudes in the zero and first moments of the photospheric lines of up to 15% and 30 km s(-1), respectively....... Conclusions. Combined long-term uninterrupted space photometry with high-precision spectroscopy is the best strategy to unravel the complex low-frequency photospheric and wind variability of B supergiants. Three-dimensional (3D) simulations of waves and of convective motions in the sub-surface layers can shed...

The HD+ dissociative recombination rate coefficient at low temperature

Directory of Open Access Journals (Sweden)

Wolf A.

2015-01-01

Full Text Available The effect of the rotational temperature of the ions is considered for low-energy dissociative recombination (DR of HD+. Merged beams measurements with HD+ ions of a rotational temperature near 300 K are compared to multichannel quantum defect theory calculations. The thermal DR rate coefficient for a Maxwellian electron velocity distribution is derived from the merged-beams data and compared to theoretical results for a range of rotational temperatures. Good agreement is found for the theory with 300 K rotational temperature. For a low-temperature plasma environment where also the rotational temperature assumes 10 K, theory predicts a considerably higher thermal DR rate coefficient. The origin of this is traced to predicted resonant structures of the collision-energy dependent DR cross section at few-meV collision energies for the particular case of HD+ ions in the rotational ground state.

[Relationship between characteristic behaviors of children with AD/HD and mothers' parenting styles].

Science.gov (United States)

Mano, Shoko; Uno, Hiroyuki

2007-01-01

Previous studies have revealed that mothers of children with attention-deficit/hyperactivity disorder (AD/HD) have an authoritarian parenting style. However, the psychological process of developing an authoritarian parenting style has yet to be clearly defined. To clarify this psychological process, the present study examined the hypothesis that the characteristic behaviors of children with AD/HD initially increase the mothers' parenting stress, which influences their parenting style. Thirty-six mothers of children with AD/HD (children's mean age: 8.1 years) and the same number of controls (children's mean age: 8.4 years) participated in the present study. The mothers' parenting stress was assessed using the Japanese Parenting Stress Index. Parenting styles were assessed using the TK-style scale for evaluating the relationships between parents and children. The results indicated that the mothers of children with AD/HD had significantly higher scores than controls for all parenting stress items and negative parenting style variables (dissatisfaction, reproach, strictness, interference, inconsistency and disagreement of 10 attitudes). Stepwise multiple regression analysis revealed that the characteristic behaviors of children with AD/HD were associated with the degree of attachment in mothers, which was related to the strict and reproachful parenting style in the AD/HD group. These results suggest that mothers of children with AD/HD are likely to have a strict and reproachful parenting style as a result of a lack of attachment with the child.

Testing stellar evolution models with the retired A star HD 185351

DEFF Research Database (Denmark)

Hjørringgaard, J. G.; Silva Aguirre, V.; White, T. R.

2017-01-01

The physical parameters of the retired A star HD 185351 were analysed in great detail by Johnson et al. using interferometry, spectroscopy, and asteroseismology. Results from all independent methods are consistent with HD 185351 having a mass in excess of 1.5 M⊙. However, the study also showed th...

Quantum stereodynamics study for the reaction F + HD

International Nuclear Information System (INIS)

Yu-Fang, Liu; Wei, Zhang; De-Heng, Shi; Jin-Feng, Sun

2009-01-01

This paper studies the quantum stereodynamics of the F + HD(ν = 0,j = 0) → HD + F/HF + D reaction at the collision energies of 0.52 and 0.87 kcal/mol. The quantum scattering calculations, based on Stark–Werner potential energy surfaces, show that the differential cross sections for the HF(ν' = 2) + D and DF(ν' = 3) + H channels are consistent with the recent theoretical results. Furthermore, the product rotational angular momentum orientation and alignment have been determined for some selected rovibrational states of the HF + D and DF + H channels. (atomic and molecular physics)

SCExAO and GPI Y JH band photometry and integral field spectroscopy of the young brown dwarf companion to HD 1160

International Nuclear Information System (INIS)

Garcia, Eugenio Victor; Currie, Thayne; Guyon, Olivier

2017-01-01

Here, we present high signal-to-noise ratio, precise Y JH photometry and Y band (0.957–1.120 μm) spectroscopy of HD 1160 B, a young substellar companion discovered from the Gemini NICI Planet Finding Campaign using the Subaru Coronagraphic Extreme Adaptive Optics instrument and the Gemini Planet Imager. HD 1160 B has typical mid-M dwarf-like infrared colors and a spectral type of M5.5_−_0_._5"+"1"."0, where the blue edge of our Y band spectrum rules out earlier spectral types. Atmospheric modeling suggests HD 1160 B has an effective temperature of 3000–3100 K, a surface gravity of log g = 4–4.5, a radius of 1.55 ± 0.10 R J, and a luminosity of log L/L _⊙ = –2.76 ± 0.05. Neither the primary's Hertzspring–Russell diagram position nor atmospheric modeling of HD 1160 B show evidence for a subsolar metallicity. Interpretation of the HD 1160 B spectroscopy depends on which stellar system components are used to estimate the age. Considering HD 1160 A, B and C jointly, we derive an age of 80–125 Myr, implying that HD 1160 B straddles the hydrogen-burning limit (70–90 M _J). If we consider HD 1160 A alone, younger ages (20–125 Myr) and a brown dwarf-like mass (35–90 M _J) are possible. Interferometric measurements of the primary, a precise Gaia parallax, and moderate-resolution spectroscopy can better constrain the system's age and how HD 1160 B fits within the context of (sub)stellar evolution.

Differentiating allergic and irritant contact dermatitis by high-definition optical coherence tomography

DEFF Research Database (Denmark)

Boone, Marc A L M; Jemec, Gregor B E; Del Marmol, V

2015-01-01

Differentiation of allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD) is important because of different management requirements. Various non-invasive tests have been used in an attempt to improve diagnosis. In irritant dermatitis, thickening of the epidermis has been a constant...... was threefold. (1) To evaluate the correlation between HD-OCT features and clinical scores of allergic and irritant patch test reactions. (2) To explore the potential of HD-OCT in optimizing the visual patch test scoring. (3) To assess in vivo the cytological and 3-D micro-architectural differences in skin...... reaction types between doubtful positive ACD and ICD. Twenty-two volunteers were patch tested using potassium(VI)dichromate, cobalt(II)chloride, nickel(II) sulfate and palladium(II)chloride. Visual patch test scoring and HD-OCT assisted patch test scoring were performed at 48 and 96 h after patch test...

Simulation and control of a HD diesel engine equipped with new EGR technology

NARCIS (Netherlands)

Dekker, H.J.; Sturm, W.L.

1996-01-01

A dynamic model of a Heavy Duty (HD) turbocharged and aftercooled diesel engine was developed. The engine was equipped with high pressure diesel injection, a Variable Geometry Turbine (VGT) and an Exhaust Gas Recirculation (EGR) system. This engine was targeted at meeting EURO4 emission

AD/HD: POSSIBLE DIAGNOSIS AND TREATMENT

Directory of Open Access Journals (Sweden)

Karl REICHELT

2008-12-01

Full Text Available The purpose of this paper is to show that a more exact diagnosis and dietary intervention in AD/HD (Attention Deficit/Hyperactivity Di­sor­der is possible and probable. The clinical symptom based diagnosis we suggest may be supplemented with physiological tests. A ge­netic and environmental inter-action is clearly involved and explainable using phenyl­ke­tonuria as a model.Method: Examining peer reviewed published papers on gut to blood, blood to brain inter­action and effect of interventions in AD/HD and our own studies in the field. The various treatment options are discussed.Results: It can be shown that a gut to brain activity is possible and probable, and dietary intervention is useful and probably safer than drugs. Preliminary data on a small five year follow up of dietary intervention is shown.

Genome-wide analysis of the HD-ZIP IV transcription factor family in Gossypium arboreum and GaHDG11 involved in osmotic tolerance in transgenic Arabidopsis.

Science.gov (United States)

Chen, Eryong; Zhang, Xueyan; Yang, Zhaoen; Wang, Xiaoqian; Yang, Zuoren; Zhang, Chaojun; Wu, Zhixia; Kong, Depei; Liu, Zhao; Zhao, Ge; Butt, Hamama Islam; Zhang, Xianlong; Li, Fuguang

2017-06-01

HD-ZIP IV proteins belong to the homeodomain-leucine zipper (HD-ZIP) transcription factor family and are involved in trichome development and drought stress in plants. Although some functions of the HD-ZIP IV group are well understood in Arabidopsis, little is known about their function in cotton. In this study, HD-ZIP genes were identified from three Gossypium species (G. arboreum, G. raimondii and G. hirsutum) and clustered into four families (HD-ZIP I, II, III and IV) to separate HD-ZIP IV from the other three families. Systematic analyses of phylogeny, gene structure, conserved domains, and expression profiles in different plant tissues and the expression patterns under osmotic stress in leaves were further conducted in G. arboreum. More importantly, ectopic overexpression of GaHDG11, a representative of the HD-ZIP IV family, confers enhanced osmotic tolerance in transgenic Arabidopsis plants, possibly due to elongated primary root length, lower water loss rates, high osmoprotectant proline levels, significant levels of antioxidants CAT, and/or SOD enzyme activity with reduced levels of MDA. Taken together, these observations may lay the foundation for future functional analysis of cotton HD-ZIP IV genes to unravel their biological roles in cotton.

Characterization of Runella slithyformis HD-Pnk, a bifunctional DNA/RNA end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase domain.

Science.gov (United States)

Munir, Annum; Shuman, Stewart

2016-11-28

5' and 3' end healing are key steps in nucleic acid break repair in which 5' -OH ends are phosphorylated by a polynucleotide kinase and 3' -PO 4 or 2',3' -cyclic-PO 4 ends are hydrolyzed by a phosphoesterase to generate the 5' -PO 4 and 3' -OH termini required for sealing by classic polynucleotide ligases. End healing and sealing enzymes are present in diverse bacterial taxa, often organized as modular units within a single multifunctional polypeptide or as subunits of a repair complex. Here we identify and characterize Runella slithyformis HD-Pnk as a novel bifunctional end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase P-loop domain. HD-Pnk phosphorylates 5' -OH polynucleotides (9-mers or longer) in the presence of magnesium and any NTP donor. HD-Pnk dephosphorylates RNA 2',3' -cyclic phosphate, RNA 3' -phosphate, RNA 2' -phosphate, and DNA 3' -phosphate ends in the presence of a transition metal cofactor, which can be nickel, copper or cobalt. HD-Pnkp homologs are present in genera from eleven bacterial phyla and are often encoded in an operon with a putative ATP-dependent polynucleotide ligase. The present study provides insights to the diversity of nucleic acid repair strategies via the characterization of Runella slithyformis HD-Pnkp as the exemplar of a novel clade of dual 5' and 3' end-healing enzymes that phosphorylate 5' -OH termini and dephosphorylate 2',3' -cyclic-PO 4 , 3' -PO 4 , and 2' -PO 4 ends. The distinctive feature of HD-Pnk is its domain composition: a fusion of an N-terminal HD phosphohydrolase module to a C-terminal P-loop polynucleotide kinase module. Homologs of Runella HD-Pnk with the same domain composition, domain order, and similar polypeptide size are distributed widely among genera from eleven bacterial phyla. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

HD 185330 — chemically peculiar 3He star in the Kepler field

Science.gov (United States)

Niemczura, E.; Vennes, S.; Różański, T.; Pigulski, A.; Hełminiak, K.; Lehmann, H.

2018-01-01

We analyzed high-resolution spectra of the chemically peculiar 3He star HD 185330. We determined its atmospheric parameters (Teff, log g, ξ) and constrained its rotation velocity and abundance pattern. In particular, we found a large (×100) phosphorus abundance excess and evidence of 3He and 4He abundance stratification in the atmosphere.

Clarifying the Status of HD 100546 as Observed by the Gemini Planet Imager

Science.gov (United States)

Currie, Thayne; Brittain, Sean; Grady, Carol A.; Kenyon, Scott J.; Muto, Takayuki

2017-12-01

HD 100546 is a young, early-type star and key laboratory for studying gas giant planet formation. GPI data taken in 2015 and reported by Currie et al. (2015) recover the previously-identified protoplanet candidate HD 100546 b and identify a second emission source at ~13--14 au: either a disk hot spot or a second protoplanetary candidate (HD 100546 "c"). In this short research note, we update the status of HD 100546 as observed by the Gemini Planet Imager by rereducing our original data using a different PSF subtraction method (KLIP instead of A-LOCI), rereducing recently public GPI Campaign Team (GPIES) data, and comparing the quality of the two data sets. Our results support the original findings in Currie et al. (2015).

A pilot study of combined working memory and inhibition training for children with AD/HD.

Science.gov (United States)

Johnstone, Stuart J; Roodenrys, Steven; Phillips, Elise; Watt, Annele J; Mantz, Sharlene

2010-03-01

Building on recent favourable outcomes using working memory (WM) training, this study examined the behavioural and physiological effect of concurrent computer-based WM and inhibition training for children with attention-deficit hyperactivity disorder (AD/HD). Using a double-blind active-control design, 29 children with AD/HD completed a 5-week at-home training programme and pre- and post-training sessions which included the assessment of overt behaviour, resting EEG, as well as task performance, skin conductance level and event-related potentials (ERPs) during a Go/Nogo task. Results indicated that after training, children from the high-intensity training condition showed reduced frequency of inattention and hyperactivity symptoms. Although there were trends for improved Go/Nogo performance, increased arousal and specific training effects for the inhibition-related N2 ERP component, they failed to reach standard levels of statistical significance. Both the low- and high-intensity conditions showed resting EEG changes (increased delta, reduced alpha and theta activity) and improved early attention alerting to Go and Nogo stimuli, as indicated by the N1 ERP component, post-training. Despite limitations, this preliminary work indicates the potential for cognitive training that concurrently targets the interrelated processes of WM and inhibition to be used as a treatment for AD/HD.

Profile of He I lambda5876 in the P-Cygni-type of star HD 152408

International Nuclear Information System (INIS)

Walborn, N.R.

1975-01-01

The blue-shifted absorption component of the P-Cygni profile at He I lambda 5876 in HD 152408 (O8: Iafpe) has been found to be extremely broad, extending -1000 km sec -1 from the emission maximum. This unusual profile is probably due to overpopulation of the lower level of lambda 5876, which permits it to form throughout a greater extent of the expanding atmosphere than most other lines. This observation confirms Hutchings' identification of very large velocities in the blue-violet spectrum of HD 152408, and in particular his interpretation of a similar feature at He I lambda 3889, which is metastable. The lambda 5876 profile in HD 152408 is compared to those in the similar but less extreme P-Cygni star HD 151804 (O8 Iaf), and in the Wolf-Rayet star HD 151932 (WN7-A). The similarity between the absorption components in HD 152408 and the WN star is striking

RETIRED A STARS AND THEIR COMPANIONS. VI. A PAIR OF INTERACTING EXOPLANET PAIRS AROUND THE SUBGIANTS 24 SEXTANIS AND HD 200964

International Nuclear Information System (INIS)

Johnson, John Asher; Payne, Matthew; Ford, Eric B.; Howard, Andrew W.; Marcy, Geoffrey W.; Clubb, Kelsey I.; Bowler, Brendan P.; Henry, Gregory W.; Fischer, Debra A.; Brewer, John M.; Schwab, Christian; Reffert, Sabine; Lowe, Thomas B.

2011-01-01

We report radial velocity (RV) measurements of the G-type subgiants 24 Sextanis (= HD 90043) and HD 200964. Both are massive, evolved stars that exhibit periodic variations due to the presence of a pair of Jovian planets. Photometric monitoring with the T12 0.80 m APT at Fairborn Observatory demonstrates both stars to be constant in brightness to ≤0.002 mag, thus strengthening the planetary interpretation of the RV variations. Based on our dynamical analysis of the RV time series, 24 Sex b, c have orbital periods of 452.8 days and 883.0 days, corresponding to semimajor axes 1.333 AU and 2.08 AU, and minimum masses 1.99 M Jup and 0.86 M Jup , assuming a stellar mass M * = 1.54 M sun . HD 200964 b, c have orbital periods of 613.8 days and 825.0 days, corresponding to semimajor axes 1.601 AU and 1.95 AU, and minimum masses 1.99 M Jup and 0.90 M Jup , assuming M * = 1.44 M sun . We also carry out dynamical simulations to properly account for gravitational interactions between the planets. Most, if not all, of the dynamically stable solutions include crossing orbits, suggesting that each system is locked in a mean-motion resonance that prevents close encounters and provides long-term stability. The planets in the 24 Sex system likely have a period ratio near 2:1, while the HD 200964 system is even more tightly packed with a period ratio close to 4:3. However, we caution that further RV observations and more detailed dynamical modeling will be required to provide definitive and unique orbital solutions for both cases, and to determine whether the two systems are truly resonant.

Mechanical Analysis of the Nb3Sn Dipole Magnet HD1

International Nuclear Information System (INIS)

Ferracin, Paolo; Bartlett, Scott E.; Caspi, Shlomo; Dietderich, Daniel R.; Gourlay, Steve A.; Hannaford, Charles R.; Hafalia, Aurelio R.; Lietzke, Alan F.; Mattafirri, Sara; Sabbi, Gianluca

2005-01-01

The Superconducting Magnet Group at Lawrence Berkeley National Laboratory (LBNL) has recently fabricated and tested HD1, a Nb3Sn dipole magnet. The magnet reached a 16 T field, and exhibited training quenches in the end regions and in the straight section. After the test, HD1 was disassembled and inspected, and a detailed 3D finite element mechanical analysis was done to investigate for possible quench triggers. The study led to minor modifications to mechanical structure and assembly procedure, which were verified in a second test (HD1b). This paper presents the results of the mechanical analysis, including strain gauge measurements and coil visual inspection. The adjustments implemented in the magnet structure are reported and their effect on magnet training discussed

Mechanical analysis of the Nb3Sn dipole magnet HD1

International Nuclear Information System (INIS)

Ferracin, Paolo; Bartlett, Scott E.; Caspi, Shlomo; Dietderich, Daniel R.; Gourlay, Steve A.; Hannaford, Carles R.; Hafalia, Aurelio R.; Lietzke, Alan F.; Mattafirri, Sara; Sabbi, Gianluca

2005-01-01

The Superconducting Magnet Group at Lawrence Berkeley National Laboratory (LBNL) has recently fabricated and tested HD1, a Nb 3 Sn dipole magnet. The magnet reached a 16 T field, and exhibited training quenches in the end regions and in the straight section. After the test, HD1 was disassembled and inspected, and a detailed 3D finite element mechanical analysis was done to investigate for possible quench triggers. The study led to minor modifications to mechanical structure and assembly procedure, which were verified in a second test (HD1b). This paper presents the results of the mechanical analysis, including strain gauge measurements and coil visual inspection. The adjustments implemented in the magnet structure are reported and their effect on magnet training discussed

SUBSTELLAR-MASS COMPANIONS TO THE K-GIANTS HD 240237, BD +48 738, AND HD 96127

International Nuclear Information System (INIS)

Gettel, S.; Wolszczan, A.; Niedzielski, A.; Nowak, G.; Adamów, M.; Zieliński, P.; Maciejewski, G.

2012-01-01

We present the discovery of substellar-mass companions to three giant stars by the ongoing Penn State-Toruń Planet Search conducted with the 9.2 m Hobby-Eberly Telescope. The most massive of the three stars, K2-giant HD 240237, has a 5.3 M J minimum mass companion orbiting the star at a 746 day period. The K0-giant BD +48 738 is orbited by a ≥0.91 M J planet which has a period of 393 days and shows a nonlinear, long-term radial velocity (RV) trend that indicates a presence of another, more distant companion, which may have a substellar mass or be a low-mass star. The K2-giant HD 96127 has a ≥4.0 M J mass companion in a 647 day orbit around the star. The two K2-giants exhibit a significant RV noise that complicates the detection of low-amplitude, periodic variations in the data. If the noise component of the observed RV variations is due to solar-type oscillations, we show, using all the published data for the substellar companions to giants, that its amplitude is anti-correlated with stellar metallicity.

The Discovery of HD 37605c and a Dispositive Null Detection of Transits of HD 37605b

DEFF Research Database (Denmark)

Xuesong Wang, Sharon; Wright, Jason T.; Cochran, William

2012-01-01

the predicted ephemeris, we performed a transit search for HD 37605b with the photometric data taken by the T12 0.8-m Automatic Photoelectric Telescope (APT) and the Microvariability and Oscillations of Stars (MOST) satellite. Though the APT photometry did not capture the transit window, it characterized...

Three-dimensional (3D) structure prediction and function analysis of the chitin-binding domain 3 protein HD73_3189 from Bacillus thuringiensis HD73.

Science.gov (United States)

Zhan, Yiling; Guo, Shuyuan

2015-01-01

Bacillus thuringiensis (Bt) is capable of producing a chitin-binding protein believed to be functionally important to bacteria during the stationary phase of its growth cycle. In this paper, the chitin-binding domain 3 protein HD73_3189 from B. thuringiensis has been analyzed by computer technology. Primary and secondary structural analyses demonstrated that HD73_3189 is negatively charged and contains several α-helices, aperiodical coils and β-strands. Domain and motif analyses revealed that HD73_3189 contains a signal peptide, an N-terminal chitin binding 3 domains, two copies of a fibronectin-like domain 3 and a C-terminal carbohydrate binding domain classified as CBM_5_12. Moreover, analysis predicted the protein's associated localization site to be the cell wall. Ligand site prediction determined that amino acid residues GLU-312, TRP-334, ILE-341 and VAL-382 exposed on the surface of the target protein exhibit polar interactions with the substrate.

Symmetry Breakdown in Ground State Dissociation of HD+

International Nuclear Information System (INIS)

Ben-Itzhak, I.; Wells, E.; Carnes, K. D.; Krishnamurthi, Vidhya; Weaver, O. L.; Esry, B. D.

2000-01-01

Experimental studies of the dissociation of the electronic ground state of HD + following ionization of HD by fast proton impact indicate that the H + +D 1s dissociation channel is more likely than the H1s+D + dissociation channel by about 7% . This isotopic symmetry breakdown is due to the finite nuclear mass correction to the Born-Oppenheimer approximation which makes the 1sσ state 3.7 meV lower than the 2pσ state at the dissociation limit. The measured fractions of the two dissociation channels are in agreement with coupled-channels calculations of 1sσ to 2pσ transitions. (c) 2000 The American Physical Society

High Definition Colonoscopy Combined with i-SCAN Imaging Technology Is Superior in the Detection of Adenomas and Advanced Lesions Compared to High Definition Colonoscopy Alone.

Science.gov (United States)

Bowman, Erik A; Pfau, Patrick R; Mitra, Arnab; Reichelderfer, Mark; Gopal, Deepak V; Hall, Benjamin S; Benson, Mark E

2015-01-01

Background. Improved detection of adenomatous polyps using i-SCAN has mixed results in small studies. Utility of i-SCAN as a primary surveillance modality for colorectal cancer screening during colonoscopy is uncertain. Aim. Comparing high definition white light endoscopy (HDWLE) to i-SCAN in their ability to detect adenomas during colonoscopy. Methods. Prospective cohort study of 1936 average risk patients who had a screening colonoscopy at an ambulatory procedure center. Patients underwent colonoscopy with high definition white light endoscopy withdrawal versus i-SCAN withdrawal during endoscopic screening exam. Primary outcome measurement was adenoma detection rate for i-SCAN versus high definition white light endoscopy. Secondary measurements included polyp size, pathology, and morphology. Results. 1007 patients underwent colonoscopy with i-SCAN and 929 with HDWLE. 618 adenomas were detected in the i-SCAN group compared to 402 in the HDWLE group (p definition white light endoscopy.

A Petunia Homeodomain-Leucine Zipper Protein, PhHD-Zip, Plays an Important Role in Flower Senescence

Science.gov (United States)

Chang, Xiaoxiao; Donnelly, Linda; Sun, Daoyang; Rao, Jingping; Reid, Michael S.; Jiang, Cai-Zhong

2014-01-01

Flower senescence is initiated by developmental and environmental signals, and regulated by gene transcription. A homeodomain-leucine zipper transcription factor, PhHD-Zip, is up-regulated during petunia flower senescence. Virus-induced gene silencing of PhHD-Zip extended flower life by 20% both in unpollinated and pollinated flowers. Silencing PhHD-Zip also dramatically reduced ethylene production and the abundance of transcripts of genes involved in ethylene (ACS, ACO), and ABA (NCED) biosynthesis. Abundance of transcripts of senescence-related genes (SAG12, SAG29) was also dramatically reduced in the silenced flowers. Over-expression of PhHD-Zip accelerated petunia flower senescence. Furthermore, PhHD-Zip transcript abundance in petunia flowers was increased by application of hormones (ethylene, ABA) and abiotic stresses (dehydration, NaCl and cold). Our results suggest that PhHD-Zip plays an important role in regulating petunia flower senescence. PMID:24551088

A Petunia homeodomain-leucine zipper protein, PhHD-Zip, plays an important role in flower senescence.

Science.gov (United States)

Chang, Xiaoxiao; Donnelly, Linda; Sun, Daoyang; Rao, Jingping; Reid, Michael S; Jiang, Cai-Zhong

2014-01-01

Flower senescence is initiated by developmental and environmental signals, and regulated by gene transcription. A homeodomain-leucine zipper transcription factor, PhHD-Zip, is up-regulated during petunia flower senescence. Virus-induced gene silencing of PhHD-Zip extended flower life by 20% both in unpollinated and pollinated flowers. Silencing PhHD-Zip also dramatically reduced ethylene production and the abundance of transcripts of genes involved in ethylene (ACS, ACO), and ABA (NCED) biosynthesis. Abundance of transcripts of senescence-related genes (SAG12, SAG29) was also dramatically reduced in the silenced flowers. Over-expression of PhHD-Zip accelerated petunia flower senescence. Furthermore, PhHD-Zip transcript abundance in petunia flowers was increased by application of hormones (ethylene, ABA) and abiotic stresses (dehydration, NaCl and cold). Our results suggest that PhHD-Zip plays an important role in regulating petunia flower senescence.

A Petunia homeodomain-leucine zipper protein, PhHD-Zip, plays an important role in flower senescence.

Directory of Open Access Journals (Sweden)

Xiaoxiao Chang

Full Text Available Flower senescence is initiated by developmental and environmental signals, and regulated by gene transcription. A homeodomain-leucine zipper transcription factor, PhHD-Zip, is up-regulated during petunia flower senescence. Virus-induced gene silencing of PhHD-Zip extended flower life by 20% both in unpollinated and pollinated flowers. Silencing PhHD-Zip also dramatically reduced ethylene production and the abundance of transcripts of genes involved in ethylene (ACS, ACO, and ABA (NCED biosynthesis. Abundance of transcripts of senescence-related genes (SAG12, SAG29 was also dramatically reduced in the silenced flowers. Over-expression of PhHD-Zip accelerated petunia flower senescence. Furthermore, PhHD-Zip transcript abundance in petunia flowers was increased by application of hormones (ethylene, ABA and abiotic stresses (dehydration, NaCl and cold. Our results suggest that PhHD-Zip plays an important role in regulating petunia flower senescence.

FIVE PLANETS AND AN INDEPENDENT CONFIRMATION OF HD 196885Ab FROM LICK OBSERVATORY

International Nuclear Information System (INIS)

Fischer, Debra; Isaacson, Howard; Giguere, Matt; McCarthy, Chris; Driscoll, Peter; Marcy, Geoffrey W.; Howard, Andrew; Peek, Katherine; Valenti, Jeff; Wright, Jason T.; Henry, Gregory W.; Johnson, John Asher

2009-01-01

We present time series Doppler data from Lick Observatory that reveal the presence of long-period planetary companions orbiting nearby stars. The typical eccentricity of these massive planets are greater than the mean eccentricity of known exoplanets. HD 30562b has Msin i = 1.29 M Jup , with semimajor axis of 2.3 AU and eccentricity 0.76. The host star has a spectral type F8V and is metal rich. HD 86264b has Msin i = 7.0 M Jup , a rel = 2.86 AU, an eccentricity e = 0.7 and orbits a metal-rich, F7V star. HD 87883b has Msin i = 1.78 M Jup , a rel = 3.6 AU, e = 0.53 and orbits a metal-rich K0V star. HD 89307b has Msin i = 1.78 M Jup , a rel = 3.3 AU, e = 0.24 and orbits a G0V star with slightly subsolar metallicity. HD 148427b has Msin i = 0.96 M Jup , a rel = 0.93 AU, eccentricity of 0.16 and orbits a metal rich K0 subgiant. We also present velocities for a planet orbiting the F8V metal-rich binary star, HD 196885A. The planet has Msin i = 2.58 M Jup , a rel = 2.37 AU, and orbital eccentricity of 0.48, in agreement with the independent discovery by Correia et al.

Dayside atmospheric structure of HD209458b from Spitzer eclipses

Science.gov (United States)

Reinhard, Matthew; Harrington, Joseph; Challener, Ryan; Cubillos, Patricio; Blecic, Jasmina

2017-10-01

HD209458b is a hot Jupiter with a radius of 1.26 ± 0.08 Jupiter radii (Richardson et al, 2006) and a mass of 0.64 ± 0.09 Jupiter masses (Snellen et al, 2010). The planet orbits a G0 type star with an orbital period of 3.52472 ± 2.81699e-05 days, and a relatively low eccentricity of 0.0082 +0.0078/-0.0082 (Wang and Ford 2013). We report the analysis of observations of HD209458b during eclipse, taken in the 3.6 and 4.5 micron channels by the Spitzer Space Telescope's Infrared Array Camera (Program 90186). We produce a photometric light curve of the eclipses in both channels, using our Photometry for Orbits Eclipses and Transits (POET) code, and calculate the brightness temperatures and eclipse depths. We also present best estimates of the atmospheric parameters of HD209458b using our Bayesian Atmospheric Radiative Transfer (BART) code. These are some preliminary results of what will be an analysis of all available Spitzer data for HD209458b. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

Transit confirmation and improved stellar and planet parameters for the super-Earth HD 97658 b and its host star

Energy Technology Data Exchange (ETDEWEB)

Van Grootel, V.; Gillon, M.; Scuflaire, R. [Institut d' Astrophysique et de Géophysique, Université de Liège, 17 Allée du 6 Août, B-4000 Liège (Belgium); Valencia, D. [Department of Physical and Environmental Sciences, University of Toronto, 1265 Military Trail, Toronto, ON, M1C 1A4 (Canada); Madhusudhan, N.; Demory, B.-O.; Queloz, D. [Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA (United Kingdom); Dragomir, D. [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Dr. Suite 102, Goleta, CA 93117 (United States); Howe, A. R.; Burrows, A. S. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Deming, D. [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Ehrenreich, D.; Lovis, C.; Mayor, M.; Pepe, F.; Segransan, D.; Udry, S. [Observatoire de Genève, Université de Genève, 51 Chemin des Maillettes, CH-1290 Sauverny (Switzerland); Seager, S., E-mail: valerie.vangrootel@ulg.ac.be [Department of Earth, Atmospheric and Planetary Sciences, Department of Physics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States)

2014-05-01

Super-Earths transiting nearby bright stars are key objects that simultaneously allow for accurate measurements of both their mass and radius, providing essential constraints on their internal composition. We present here the confirmation, based on Spitzer transit observations, that the super-Earth HD 97658 b transits its host star. HD 97658 is a low-mass (M {sub *} = 0.77 ± 0.05 M {sub ☉}) K1 dwarf, as determined from the Hipparcos parallax and stellar evolution modeling. To constrain the planet parameters, we carry out Bayesian global analyses of Keck-High Resolution Echelle Spectrometer (Keck-HIRES) radial velocities and Microvariability and Oscillations of STars (MOST) and Spitzer photometry. HD 97658 b is a massive (M{sub P}=7.55{sub −0.79}{sup +0.83} M{sub ⊕}) and large (R{sub P}=2.247{sub −0.095}{sup +0.098}R{sub ⊕} at 4.5 μm) super-Earth. We investigate the possible internal compositions for HD 97658 b. Our results indicate a large rocky component, of at least 60% by mass, and very little H-He components, at most 2% by mass. We also discuss how future asteroseismic observations can improve the knowledge of the HD 97658 system, in particular by constraining its age. Orbiting a bright host star, HD 97658 b will be a key target for upcoming space missions such as the Transiting Exoplanet Survey Satellite (TESS), the Characterizing Exoplanet Satellite (CHEOPS), the Planetary Transits and Oscillations of stars (PLATO), and the James Webb Space Telescope to characterize thoroughly its structure and atmosphere.

EVIDENCE FOR THE DIRECT DETECTION OF THE THERMAL SPECTRUM OF THE NON-TRANSITING HOT GAS GIANT HD 88133 b

KAUST Repository

Piskorz, Danielle

2016-11-23

We target the thermal emission spectrum of the non-transiting gas giant HD 88133 b with high-resolution near-infrared spectroscopy, by treating the planet and its host star as a spectroscopic binary. For sufficiently deep summed flux observations of the star and planet across multiple epochs, it is possible to resolve the signal of the hot gas giant\\'s atmosphere compared to the brighter stellar spectrum, at a level consistent with the aggregate shot noise of the full data set. To do this, we first perform a principal component analysis to remove the contribution of the Earth\\'s atmosphere to the observed spectra. Then, we use a cross-correlation analysis to tease out the spectra of the host star and HD 88133 b to determine its orbit and identify key sources of atmospheric opacity. In total, six epochs of Keck NIRSPEC L-band observations and three epochs of Keck NIRSPEC K-band observations of the HD 88133 system were obtained. Based on an analysis of the maximum likelihood curves calculated from the multi-epoch cross-correlation of the full data set with two atmospheric models, we report the direct detection of the emission spectrum of the non-transiting exoplanet HD 88133 b and measure a radial projection of the Keplerian orbital velocity of 40 +/- 15 km s(-1), a true mass of 1.02(-0.28)(+0.61) M-J, a nearly face-on orbital inclination of 15(-5)(+60), and an atmosphere opacity structure at high dispersion dominated by water vapor. This, combined with 11 years of radial velocity measurements of the system, provides the most up-to-date ephemeris for HD 88133.

76 FR 2243 - List of Approved Spent Fuel Storage Casks: NUHOMS ® HD System Revision 1

Science.gov (United States)

2011-01-13

... Storage Casks: NUHOMS [supreg] HD System Revision 1 AGENCY: Nuclear Regulatory Commission. ACTION: Direct... fuel storage regulations by revising the Transnuclear, Inc. (TN) NUHOMS [supreg] HD System listing... NUHOMS [supreg] HD System cask design listed in Sec. 72.214 (List of approved spent fuel storage casks...

Mechanical Design of HD2, a 15 T Nb3Sn Dipole Magnet with a 35 mm Bore

Energy Technology Data Exchange (ETDEWEB)

Ferracin, P.; Bartlett, S.E.; Caspi, S.; Dietderich, D.R.; Gourlay, S.A.; Hafalia, A.R.; Hannaford, C.R.; Lietzke, A.F.; Mattafirri, S.; McInturff, A.D.; Sabbi, G.L.

2006-06-01

After the fabrication and test of HD1, a 16 T Nb{sub 3}Sn dipole magnet based on flat racetrack coil configuration, the Superconducting Magnet Program at Lawrence Berkeley National Laboratory (LBNL) is developing the Nb{sub 3}Sn dipole HD2. With a dipole field above 15 T, a 35 mm clear bore, and nominal field harmonics within a fraction of one unit, HD2 represents a further step towards the application of block-type coils to high-field accelerator magnets. The design features tilted racetrack-type ends, to avoid obstructing the beam path, and a 4 mm thick stainless steel tube, to support the coil during the preloading operation. The mechanical structure, similar to the one used for HD1, is based on an external aluminum shell pretensioned with pressurized bladders. Axial rods and stainless steel plates provide longitudinal support to the coil ends during magnet excitation. A 3D finite element analysis has been performed to evaluate stresses and deformations from assembly to excitation, with particular emphasis on conductor displacements due to Lorentz forces. Numerical results are presented and discussed.

R- and s-process nuclei in the early history of the galaxy: HD 122563

International Nuclear Information System (INIS)

Sneden, C.; Parthasarathy, M.

1983-01-01

New high-resolution, high signal-to-noise spectra in the blue and ultraviolet spectral regions have been obtained for the extremely metal-poor giant star HD 122563. A complete model atmosphere, spectrum synthesis analysis of this star has been performed, employing a large number of weak iron-peak species lines and laboratory oscillator strengths. Spectral features of many rare earth elements have been detected in the ultraviolet. The large overdeficiency of nearly a factor of 10 for the s-process element barium is confirmed and is shown to extend to the other s-process elements La, Ce, Pr, Nd, and Sm. The r-process elements Eu, Gd, Dy, and possibly Er and Yb are less deficient than the s-process elements but do exhibit lower ratios with respect to iron-peak elements than in the Sun. A supplementary differential analysis of HD 122563 with respect to the Sun shows that the heavy-element abundances are not very model-atmosphere dependent. The heavy-element abundances can be understood with nucleosynthesis models in which the progenitors of this star produce mainly r-process isotopes. A small contribution of the s-process to the creation of the elements Sr, Y, Zr, and possibly Ba is not ruled out, but such traditional s-process elements as La, Pr, and Nd appear to have been made in the r-process in stellar generations prior to the formation of HD 122563

HD 140283: A STAR IN THE SOLAR NEIGHBORHOOD THAT FORMED SHORTLY AFTER THE BIG BANG

Energy Technology Data Exchange (ETDEWEB)

Bond, Howard E.; Nelan, Edmund P. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); VandenBerg, Don A. [Department of Physics and Astronomy, University of Victoria, P.O. Box 3055, Victoria, BC V8W 3P6 (Canada); Schaefer, Gail H. [The CHARA Array of Georgia State University, Mount Wilson Observatory, Mount Wilson, CA 91023 (United States); Harmer, Dianne, E-mail: bond@stsci.edu, E-mail: nelan@stsci.edu, E-mail: vandenbe@uvic.ca, E-mail: schaefer@chara-array.org, E-mail: diharmer@noao.edu [National Optical Astronomy Observatories, 950 North Cherry Avenue, Tucson, AZ 85726 (United States)

2013-03-01

HD 140283 is an extremely metal-deficient and high-velocity subgiant in the solar neighborhood, having a location in the Hertzsprung-Russell diagram where absolute magnitude is most sensitive to stellar age. Because it is bright, nearby, unreddened, and has a well-determined chemical composition, this star avoids most of the issues involved in age determinations for globular clusters. Using the Fine Guidance Sensors on the Hubble Space Telescope, we have measured a trigonometric parallax of 17.15 {+-} 0.14 mas for HD 140283, with an error one-fifth of that determined by the Hipparcos mission. Employing modern theoretical isochrones, which include effects of helium diffusion, revised nuclear reaction rates, and enhanced oxygen abundance, we use the precise distance to infer an age of 14.46 {+-} 0.31 Gyr. The quoted error includes only the uncertainty in the parallax, and is for adopted surface oxygen and iron abundances of [O/H] = -1.67 and [Fe/H] = -2.40. Uncertainties in the stellar parameters and chemical composition, especially the oxygen content, now contribute more to the error budget for the age of HD 140283 than does its distance, increasing the total uncertainty to about {+-}0.8 Gyr. Within the errors, the age of HD 140283 does not conflict with the age of the Universe, 13.77 {+-} 0.06 Gyr, based on the microwave background and Hubble constant, but it must have formed soon after the big bang.

ALMA 1.3 Millimeter Map of the HD 95086 System -- A Young Analog of the HR 8799 System

Science.gov (United States)

Su, Kate; MacGregor, Meredith Ann; Booth, Mark; Wilner, David; Malhotra, Renu; Morrison, Sarah; OST STDT

2018-01-01

Planets and minor bodies such as asteroids, Kuiper-belt objects and comets are integral components of a planetary system. Interactions among them leave clues about the formation process of a planetary system. The signature of such interactions is best illustrated through resolved observations of its debris disk. Here we present ALMA 1.3 mm observations of HD 95086, a young analog of the HR 8799 system, that hosts a directly imaged giant planet b and a massive debris disk with both asteroid- and Kuiper-belt analogs. The location of the Kuiper-belt analog is resolved for the first time. Our deep ALMA map also reveals a bright source located near the edge of the ring. The properties of the source, based on limited data, are consistent with it being a luminous star-forming galaxy at high redshift. We will discuss future, resolved observations of debris disks, highlighting the potential of the Origins Space Telescope (OST), one of the four science and technology definition studies commissioned by NASA Headquarters for the 2020 Astronomy and Astrophysics Decadal survey.

High-definition velocity-space tomography of fast-ion dynamics

DEFF Research Database (Denmark)

Salewski, Mirko; Geiger, B.; Jacobsen, A.S.

2016-01-01

Velocity-space tomography of the fast-ion distribution function in a fusion plasma is usually a photon-starved tomography method due to limited optical access and signal-to-noise ratio of fast-ion Dα (FIDA) spectroscopy as well as the strive for high-resolution images. In high-definition tomography...... information to reconstruct where in velocity space the measurements and the simulation disagree. This alternative approach is demonstrated for four-view as well as for two-view FIDA measurements. The high-definition tomography tools allow us to study fast ions in sawtoothing plasmas and the formation of NBI...

Methylphenidate Improves Working Memory and Set-Shifting in AD/HD: Relationships to Baseline Memory Capacity

Science.gov (United States)

Mehta, Mitul A.; Goodyer, Ian M.; Sahakian, Barbara J.

2004-01-01

Objective: Catecholamine stimulant drugs are highly efficacious treatments for attention deficit/hyperactivity disorders (AD/HD). Catecholamine modulation in humans influences performance of numerous cognitive tasks, including tests of attention and working memory (WM). Clear delineation of the effects of methylphenidate upon such cognitive…

Very High-Risk Localized Prostate Cancer: Outcomes Following Definitive Radiation

International Nuclear Information System (INIS)

Narang, Amol K.; Gergis, Carol; Robertson, Scott P.; He, Pei; Ram, Ashwin N.; McNutt, Todd R.; Griffith, Emily; DeWeese, Theodore A.; Honig, Stephanie; Singh, Harleen; Song, Danny Y.; Tran, Phuoc T.; DeWeese, Theodore L.

2016-01-01

Purpose: Existing definitions of high-risk prostate cancer consist of men who experience significant heterogeneity in outcomes. As such, criteria that identify a subpopulation of National Comprehensive Cancer Network (NCCN) high-risk prostate cancer patients who are at very high risk (VHR) for poor survival outcomes following prostatectomy were recently developed at our institution and include the presence of any of the following disease characteristics: multiple NCCN high-risk factors, primary Gleason pattern 5 disease and/or ≥5 biopsy cores with Gleason sums of 8 to 10. Whether these criteria also apply to men undergoing definitive radiation is unclear, as is the optimal treatment regimen in these patients. Methods and Materials: All men consecutively treated with definitive radiation by a single provider from 1993 to 2006 and who fulfilled criteria for NCCN high-risk disease were identified (n=288), including 99 patients (34%) with VHR disease. Multivariate-adjusted competing risk regression models were constructed to assess associations between the VHR definition and biochemical failure (BF), distant metastasis (DM), and prostate cancer–specific mortality (PCSM). Multivariate-adjusted Cox regression analysis assessed the association of the VHR definition with overall mortality (OM). Cumulative incidences of failure endpoints were compared between VHR men and other NCCN high-risk men. Results: Men with VHR disease compared to other NCCN high-risk men experienced a higher 10-year incidence of BF (54.0% vs 35.4%, respectively, P<.001), DM (34.9% vs 13.4%, respectively, P<.001), PCSM (18.5% vs 5.9%, respectively, P<.001), and OM (36.4% vs 27.0%, respectively, P=.04). VHR men with a detectable prostate-specific antigen (PSA) concentration at the end of radiation (EOR) remained at high risk of 10-year PCSM compared to VHR men with an undetectable EOR PSA (31.0% vs 13.7%, respectively, P=.05). Conclusions: NCCN high-risk prostate cancer patients who meet VHR

Hearily reddened Hg-Mn star HD 29647

International Nuclear Information System (INIS)

Strajzhis, V.; Glagolevskij, Yu.V.; Romanyuk, I.I.; Bychkov, V.D.; AN SSSR, Nizhnij Arkhyz. Spetsial'naya Astrofizicheskaya Observatoriya)

1982-01-01

A heavily reddened HD 29647 (V=8sup(m).4) star is investigated using the 6-meter telescope spectrograms with dispersions 9 and 28 A/mm and photometric observations in the Vilnius seven- color system. Parameters Tsub(e)=15600 K (corresponding spectral type B5) and log g=3.70 from hydrogen lines and Balmer jump were obtained. HD 29647 is a peculiar star of the Hg-Mn type. The radial velocity of the star is+14.1+-1.0 km/s, almost identical with that of the dark Taurus cloud and its T Tauri-type variables. If the star is near the front edge of the dark cloud at the distance of 165 pc and has Esub(B-V)=1.06, its visual absolute magnitude is - 0sup(m).9. Photometric observations permit to suspect a slight varia bility in the U, P, and X colors [ru

High-definition television evaluation for remote handling task performance

International Nuclear Information System (INIS)

Fujita, Y.; Omori, E.; Hayashi, S.; Draper, J.V.; Herndon, J.N.

1986-01-01

In a plant that employs remote handling techniques for equipment maintenance, operators perform maintenance tasks primarily by using the information from television systems. The efficiency of the television system has a significant impact on remote maintenance task performance. High-definition television (HDTV) transmits a video image with more than twice the number of horizontal scan lines as standard-resolution television (1125 for HDTV to 525 for standard-resolution NTSC television). The added scan lines dramatically improve the resolution of images on the HDTV monitors. This paper describes experiments designed to evaluate the impact of HDTV on the performance of typical remote tasks. The experiments described in this paper compared the performance of four operators using HDTV with their performance while using other television systems. The experiments included four television systems: (a) high-definition color television, (b) high-definition monochromatic television, (c) standard-resolution monochromatic television, and (d) standard-resolution stereoscopic monochromatic television

The Stroop Revisited: A Meta-Analysis of Interference Control in AD/HD

Science.gov (United States)

Van Mourik, Rosa; Oosterlaan, Jaap; Sergeant, Joseph A.

2005-01-01

Background: An inhibition deficit, including poor interference control, has been implicated as one of the core deficits in AD/HD. Interference control is clinically measured by the Stroop Colour-Word Task. The aim of this meta-analysis was to investigate the strength of an interference deficit in AD/HD as measured by the Stroop Colour-Word Task…

CHANDRA CHARACTERIZATION OF X-RAY EMISSION IN THE YOUNG F-STAR BINARY SYSTEM HD 113766

International Nuclear Information System (INIS)

Lisse, C. M.; Christian, D. J.; Wolk, S. J.; Günther, H. M.; Chen, C. H.; Grady, C. A.

2017-01-01

Using Chandra , we have obtained imaging X-ray spectroscopy of the 10–16 Myr old F-star binary HD 113766. We individually resolve the 1.″4 separation binary components for the first time in the X-ray and find a total 0.3–2.0 keV luminosity of 2.2 × 10 29 erg s −1 , consistent with previous RASS estimates. We find emission from the easternmost, infrared-bright, dusty member HD 113766A to be only ∼10% that of the western, infrared-faint member HD 113766B. There is no evidence for a 3rd late-type stellar or substellar member of HD 113766 with L x  > 6 × 10 25 erg s −1 within 2′ of the binary pair. The ratio of the two stars’ X-ray luminosity is consistent with their assignments as F2V and F6V by Pecaut et al. The emission is soft for both stars, kT Apec  = 0.30–0.50 keV, suggesting X-rays produced by stellar rotation and/or convection in young dynamos, but not accretion or outflow shocks, which we rule out. A possible 2.8 ± 0.15 (2 σ ) hr modulation in the HD 113766B X-ray emission is seen, but at very low confidence and of unknown provenance. Stellar wind drag models corresponding to L x  ∼ 2 × 10 29 erg s −1 argue for a 1 mm dust particle lifetime around HD 113766B of only ∼90,0000 years, suggesting that dust around HD 113766B is quickly removed, whereas 1 mm sized dust around HD 113766A can survive for >1.5 × 10 6 years. At 10 28 –10 29 erg s −1 X-ray luminosity, astrobiologically important effects, like dust warming and X-ray photolytic organic synthesis, are likely for any circumstellar material in the HD 113766 systems.

Modeling the HD 32297 Debris Disk With Far-Infrared Herschel Data

Science.gov (United States)

Donaldson, J.K.; Lebreton, J.; Roberge, A.; Augereau, J.-C.; Krivov, A. V.

2013-01-01

HD 32297 is a young A-star (approx. 30 Myr) 112 pc away with a bright edge-on debris disk that has been resolved in scattered light. We observed the HD 32297 debris disk in the far-infrared and sub-millimeter with the Herschel Space Observatory PACS and SPIRE instruments, populating the spectral energy distribution (SED) from 63 to 500 micron..We aimed to determine the composition of dust grains in the HD 32297 disk through SED modeling, using geometrical constraints from the resolved imaging to break the degeneracies inherent in SED modeling. We found the best fitting SED model has two components: an outer ring centered around 110 AU, seen in the scattered light images, and an inner disk near the habitable zone of the star. The outer disk appears to be composed of grains>2 micron consisting of silicates, carbonaceous material, and water ice with an abundance ratio of 1:2:3 respectively and 90% porosity. These grains appear consistent with cometary grains, implying the underlying planetesimal population is dominated by comet-like bodies. We also discuss the 3.7 sigma detection of [C ii] emission at 158 micron with the Herschel PACS instrument, making HD 32297 one of only a handful of debris disks with circumstellar gas detected

Characterization of Runella slithyformis HD-Pnk, a Bifunctional DNA/RNA End-Healing Enzyme Composed of an N-Terminal 2′,3′-Phosphoesterase HD Domain and a C-Terminal 5′-OH Polynucleotide Kinase Domain

Science.gov (United States)

Munir, Annum

2016-01-01

ABSTRACT 5′- and 3′-end-healing reactions are key steps in nucleic acid break repair in which 5′-OH ends are phosphorylated by a polynucleotide kinase (Pnk) and 3′-PO4 or 2′,3′-cyclic-PO4 ends are hydrolyzed by a phosphoesterase to generate the 5′-PO4 and 3′-OH termini required for sealing by classic polynucleotide ligases. End-healing and sealing enzymes are present in diverse bacterial taxa, often organized as modular units within a single multifunctional polypeptide or as subunits of a repair complex. Here we identify and characterize Runella slithyformis HD-Pnk as a novel bifunctional end-healing enzyme composed of an N-terminal 2′,3′-phosphoesterase HD domain and a C-terminal 5′-OH polynucleotide kinase P-loop domain. HD-Pnk phosphorylates 5′-OH polynucleotides (9-mers or longer) in the presence of magnesium and any nucleoside triphosphate donor. HD-Pnk dephosphorylates RNA 2′,3′-cyclic phosphate, RNA 3′-phosphate, RNA 2′-phosphate, and DNA 3′-phosphate ends in the presence of a transition metal cofactor, which can be nickel, copper, or cobalt. HD-Pnk homologs are present in genera from 11 bacterial phyla and are often encoded in an operon with a putative ATP-dependent polynucleotide ligase. IMPORTANCE The present study provides insights regarding the diversity of nucleic acid repair strategies via the characterization of Runella slithyformis HD-Pnk as the exemplar of a novel clade of dual 5′- and 3′-end-healing enzymes that phosphorylate 5′-OH termini and dephosphorylate 2′,3′-cyclic-PO4, 3′-PO4, and 2′-PO4 ends. The distinctive feature of HD-Pnk is its domain composition, i.e., a fusion of an N-terminal HD phosphohydrolase module and a C-terminal P-loop polynucleotide kinase module. Homologs of Runella HD-Pnk with the same domain composition, same domain order, and similar polypeptide sizes are distributed widely among genera from 11 bacterial phyla. PMID:27895092

Effects of High-Definition Anodal Transcranial Direct Current Stimulation Applied Simultaneously to Both Primary Motor Cortices on Bimanual Sensorimotor Performance

Directory of Open Access Journals (Sweden)

Nils H. Pixa

2017-07-01

Full Text Available Many daily activities, such as tying one’s shoe laces, opening a jar of jam or performing a free throw in basketball, require the skillful coordinated use of both hands. Even though the non-invasive method of transcranial direct current stimulation (tDCS has been repeatedly shown to improve unimanual motor performance, little is known about its effects on bimanual motor performance. More knowledge about how tDCS may improve bimanual behavior would be relevant to motor recovery, e.g., in persons with bilateral impairment of hand function. We therefore examined the impact of high-definition anodal tDCS (HD-atDCS on the performance of a bimanual sequential sensorimotor task. Thirty-two volunteers (age M = 24.25; SD = 2.75; 14 females participated in this double-blind study and performed sport stacking in six experimental sessions. In sport stacking, 12 specially designed cups must be stacked (stacked up and dismantled (stacked down in predefined patterns as fast as possible. During a pretest, posttest and follow-up test, two sport stacking formations (3-6-3 stack and 1-10-1 stack were performed. Between the pretest and posttest, all participants were trained in sport stacking with concurrent brain stimulation for three consecutive days. The experimental group (STIM-M1 received HD-atDCS over both primary motor cortices (M1, while the control group received a sham stimulation (SHAM. Three-way analysis of variance (ANOVA revealed a significant main effect of TIME and a significant interaction of TIME × GROUP. No significant effects were found for GROUP, nor for the three-way interaction of TIME × GROUP × FORMATION. Further two-way ANOVAs showed a significant main effect of TIME and a non-significant main effect for GROUP in both sport stacking formations. A significant interaction between TIME × GROUP was found only for the 3-6-3 formation, indicating superior performance gains for the experimental group (STIM-M1. To account and control for

Effects of High-Definition Anodal Transcranial Direct Current Stimulation Applied Simultaneously to Both Primary Motor Cortices on Bimanual Sensorimotor Performance

Science.gov (United States)

Pixa, Nils H.; Steinberg, Fabian; Doppelmayr, Michael

2017-01-01

Many daily activities, such as tying one’s shoe laces, opening a jar of jam or performing a free throw in basketball, require the skillful coordinated use of both hands. Even though the non-invasive method of transcranial direct current stimulation (tDCS) has been repeatedly shown to improve unimanual motor performance, little is known about its effects on bimanual motor performance. More knowledge about how tDCS may improve bimanual behavior would be relevant to motor recovery, e.g., in persons with bilateral impairment of hand function. We therefore examined the impact of high-definition anodal tDCS (HD-atDCS) on the performance of a bimanual sequential sensorimotor task. Thirty-two volunteers (age M = 24.25; SD = 2.75; 14 females) participated in this double-blind study and performed sport stacking in six experimental sessions. In sport stacking, 12 specially designed cups must be stacked (stacked up) and dismantled (stacked down) in predefined patterns as fast as possible. During a pretest, posttest and follow-up test, two sport stacking formations (3-6-3 stack and 1-10-1 stack) were performed. Between the pretest and posttest, all participants were trained in sport stacking with concurrent brain stimulation for three consecutive days. The experimental group (STIM-M1) received HD-atDCS over both primary motor cortices (M1), while the control group received a sham stimulation (SHAM). Three-way analysis of variance (ANOVA) revealed a significant main effect of TIME and a significant interaction of TIME × GROUP. No significant effects were found for GROUP, nor for the three-way interaction of TIME × GROUP × FORMATION. Further two-way ANOVAs showed a significant main effect of TIME and a non-significant main effect for GROUP in both sport stacking formations. A significant interaction between TIME × GROUP was found only for the 3-6-3 formation, indicating superior performance gains for the experimental group (STIM-M1). To account and control for baseline

RESONANCES REQUIRED: DYNAMICAL ANALYSIS OF THE 24 Sex AND HD 200964 PLANETARY SYSTEMS

Energy Technology Data Exchange (ETDEWEB)

Wittenmyer, Robert A.; Horner, Jonathan; Tinney, C. G., E-mail: rob@phys.unsw.edu.au [Department of Astrophysics, School of Physics, Faculty of Science, University of New South Wales, NSW 2052 (Australia)

2012-12-20

We perform several suites of highly detailed dynamical simulations to investigate the architectures of the 24 Sextantis and HD 200964 planetary systems. The best-fit orbital solution for the two planets in the 24 Sex system places them on orbits with periods that lie very close to 2:1 commensurability, while that for the HD 200964 system places the two planets therein in orbits whose periods lie close to a 4:3 commensurability. In both cases, the proposed best-fit orbits are mutually crossing-a scenario that is only dynamically feasible if the planets are protected from close encounters by the effects of mutual mean-motion resonance (MMR). Our simulations reveal that the best-fit orbits for both systems lie within narrow islands of dynamical stability, and are surrounded by much larger regions of extreme instability. As such, we show that the planets are only feasible if they are currently trapped in mutual MMR-the 2:1 resonance in the case of 24 Sex b and c, and the 4:3 resonance in the case of HD 200964 b and c. In both cases, the region of stability is strongest and most pronounced when the planetary orbits are mutually coplanar. As the inclination of planet c with respect to planet b is increased, the stability of both systems rapidly collapses.

The 4.5 μm full-orbit phase curve of the hot Jupiter HD 209458b

International Nuclear Information System (INIS)

Zellem, Robert T.; Griffith, Caitlin A.; Showman, Adam P.; Lewis, Nikole K.; Knutson, Heather A.; Fortney, Jonathan J.; Laughlin, Gregory; Cowan, Nicolas B.; Agol, Eric; Burrows, Adam; Charbonneau, David; Deming, Drake; Langton, Jonathan

2014-01-01

The hot Jupiter HD 209458b is particularly amenable to detailed study as it is among the brightest transiting exoplanet systems currently known (V-mag = 7.65; K-mag = 6.308) and has a large planet-to-star contrast ratio. HD 209458b is predicted to be in synchronous rotation about its host star with a hot spot that is shifted eastward of the substellar point by superrotating equatorial winds. Here we present the first full-orbit observations of HD 209458b, in which its 4.5 μm emission was recorded with Spitzer/IRAC. Our study revises the previous 4.5 μm measurement of HD 209458b's secondary eclipse emission downward by ∼35% to 0.1391% −0.0069% +0.0072% , changing our interpretation of the properties of its dayside atmosphere. We find that the hot spot on the planet's dayside is shifted eastward of the substellar point by 40.°9 ± 6.°0, in agreement with circulation models predicting equatorial superrotation. HD 209458b's dayside (T bright = 1499 ± 15 K) and nightside (T bright = 972 ± 44 K) emission indicate a day-to-night brightness temperature contrast smaller than that observed for more highly irradiated exoplanets, suggesting that the day-to-night temperature contrast may be partially a function of the incident stellar radiation. The observed phase curve shape deviates modestly from global circulation model predictions potentially due to disequilibrium chemistry or deficiencies in the current hot CH 4 line lists used in these models. Observations of the phase curve at additional wavelengths are needed in order to determine the possible presence and spatial extent of a dayside temperature inversion, as well as to improve our overall understanding of this planet's atmospheric circulation.

The 4.5 μm full-orbit phase curve of the hot Jupiter HD 209458b

Energy Technology Data Exchange (ETDEWEB)

Zellem, Robert T.; Griffith, Caitlin A.; Showman, Adam P. [Lunar and Planetary Laboratory, University of Arizona, 1629 East University Boulevard, Tucson, AZ 85721 (United States); Lewis, Nikole K. [Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States); Knutson, Heather A. [Division of Geological and Planetary Sciences, MC 170-25 1200 East California Boulevard, Pasadena, CA 91125 (United States); Fortney, Jonathan J.; Laughlin, Gregory [Department of Astronomy and Astrophysics, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Cowan, Nicolas B. [Department of Earth and Planetary Sciences, Northwestern University, Technological Institute, 2145 Sheridan Road, Evanston, IL 60208 (United States); Agol, Eric [Astronomy Department, University of Washington, Physics-Astronomy Building, 3910 15th Avenue NE, Seattle, WA 98195 (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, 4 Ivy Lane, Peyton Hall, Princeton University, Princeton, NJ 08544 (United States); Charbonneau, David [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street MS-16, Cambridge, MA 02138 (United States); Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Langton, Jonathan, E-mail: rzellem@lpl.arizona.edu [Physics Department, Principia College, 1 Maybeck Place, Elsah, IL 62028 (United States)

2014-07-20

The hot Jupiter HD 209458b is particularly amenable to detailed study as it is among the brightest transiting exoplanet systems currently known (V-mag = 7.65; K-mag = 6.308) and has a large planet-to-star contrast ratio. HD 209458b is predicted to be in synchronous rotation about its host star with a hot spot that is shifted eastward of the substellar point by superrotating equatorial winds. Here we present the first full-orbit observations of HD 209458b, in which its 4.5 μm emission was recorded with Spitzer/IRAC. Our study revises the previous 4.5 μm measurement of HD 209458b's secondary eclipse emission downward by ∼35% to 0.1391%{sub −0.0069%}{sup +0.0072%}, changing our interpretation of the properties of its dayside atmosphere. We find that the hot spot on the planet's dayside is shifted eastward of the substellar point by 40.°9 ± 6.°0, in agreement with circulation models predicting equatorial superrotation. HD 209458b's dayside (T{sub bright} = 1499 ± 15 K) and nightside (T{sub bright} = 972 ± 44 K) emission indicate a day-to-night brightness temperature contrast smaller than that observed for more highly irradiated exoplanets, suggesting that the day-to-night temperature contrast may be partially a function of the incident stellar radiation. The observed phase curve shape deviates modestly from global circulation model predictions potentially due to disequilibrium chemistry or deficiencies in the current hot CH{sub 4} line lists used in these models. Observations of the phase curve at additional wavelengths are needed in order to determine the possible presence and spatial extent of a dayside temperature inversion, as well as to improve our overall understanding of this planet's atmospheric circulation.

Treating AD/HD with Hypnosis and Neurotherapy.

Science.gov (United States)

Barabasz, Arreed; Barabasz, Marianne

2000-01-01

Presents details of Instant Alert Hypnosis procedure as an adjunct to neurotherapy in the treatment of attention deficit/hyperactivity disorder. Discusses AD/HD diagnostic issues, demographics, traditional treatments, neurological basis, EEG assessment, implications for the use of hypnosis, and the efficacy and promise of neurotherapy with and…

Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database.

Science.gov (United States)

Kalathur, Ravi Kiran Reddy; Hernández-Prieto, Miguel A; Futschik, Matthias E

2012-06-28

Huntington's disease (HD) is a fatal progressive neurodegenerative disorder caused by the expansion of the polyglutamine repeat region in the huntingtin gene. Although the disease is triggered by the mutation of a single gene, intensive research has linked numerous other genes to its pathogenesis. To obtain a systematic overview of these genes, which may serve as therapeutic targets, CHDI Foundation has recently established the HD Research Crossroads database. With currently over 800 cataloged genes, this web-based resource constitutes the most extensive curation of genes relevant to HD. It provides us with an unprecedented opportunity to survey molecular mechanisms involved in HD in a holistic manner. To gain a synoptic view of therapeutic targets for HD, we have carried out a variety of bioinformatical and statistical analyses to scrutinize the functional association of genes curated in the HD Research Crossroads database. In particular, enrichment analyses were performed with respect to Gene Ontology categories, KEGG signaling pathways, and Pfam protein families. For selected processes, we also analyzed differential expression, using published microarray data. Additionally, we generated a candidate set of novel genetic modifiers of HD by combining information from the HD Research Crossroads database with previous genome-wide linkage studies. Our analyses led to a comprehensive identification of molecular mechanisms associated with HD. Remarkably, we not only recovered processes and pathways, which have frequently been linked to HD (such as cytotoxicity, apoptosis, and calcium signaling), but also found strong indications for other potentially disease-relevant mechanisms that have been less intensively studied in the context of HD (such as the cell cycle and RNA splicing, as well as Wnt and ErbB signaling). For follow-up studies, we provide a regularly updated compendium of molecular mechanism, that are associated with HD, at http://hdtt.sysbiolab.eu Additionally

Huntington's Disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database

Directory of Open Access Journals (Sweden)

Kalathur Ravi Kiran

2012-06-01

Full Text Available Abstract Background Huntington’s disease (HD is a fatal progressive neurodegenerative disorder caused by the expansion of the polyglutamine repeat region in the huntingtin gene. Although the disease is triggered by the mutation of a single gene, intensive research has linked numerous other genes to its pathogenesis. To obtain a systematic overview of these genes, which may serve as therapeutic targets, CHDI Foundation has recently established the HD Research Crossroads database. With currently over 800 cataloged genes, this web-based resource constitutes the most extensive curation of genes relevant to HD. It provides us with an unprecedented opportunity to survey molecular mechanisms involved in HD in a holistic manner. Methods To gain a synoptic view of therapeutic targets for HD, we have carried out a variety of bioinformatical and statistical analyses to scrutinize the functional association of genes curated in the HD Research Crossroads database. In particular, enrichment analyses were performed with respect to Gene Ontology categories, KEGG signaling pathways, and Pfam protein families. For selected processes, we also analyzed differential expression, using published microarray data. Additionally, we generated a candidate set of novel genetic modifiers of HD by combining information from the HD Research Crossroads database with previous genome-wide linkage studies. Results Our analyses led to a comprehensive identification of molecular mechanisms associated with HD. Remarkably, we not only recovered processes and pathways, which have frequently been linked to HD (such as cytotoxicity, apoptosis, and calcium signaling, but also found strong indications for other potentially disease-relevant mechanisms that have been less intensively studied in the context of HD (such as the cell cycle and RNA splicing, as well as Wnt and ErbB signaling. For follow-up studies, we provide a regularly updated compendium of molecular mechanism, that are

THz/Infrared Double Resonance Two-Photon Spectroscopy of HD+ for Determination of Fundamental Constants

Directory of Open Access Journals (Sweden)

Florin Lucian Constantin

2017-10-01

Full Text Available A double resonance two-photon spectroscopy scheme is discussed to probe jointly rotational and rovibrational transitions of ensembles of trapped HD+ ions. The two-photon transition rates and lightshifts are calculated with the two-photon tensor operator formalism. The rotational lines may be observed with sub-Doppler linewidth at the hertz level and good signal-to-noise ratio, improving the resolution in HD+ spectroscopy beyond the 10−12 level. The experimental accuracy, estimated at the 10−12 level, is comparable with the accuracy of theoretical calculations of HD+ energy levels. An adjustment of selected rotational and rovibrational HD+ lines may add clues to the proton radius puzzle, may provide an independent determination of the Rydberg constant, and may improve the values of proton-to-electron and deuteron-to-proton mass ratios beyond the 10−11 level.

Skylab ultraviolet stellar spectra - A new white dwarf, HD 149499 B

Science.gov (United States)

Parsons, S. B.; Wray, J. D.; Benedict, G. F.; Henize, K. G.; Laget, M.

1976-01-01

The letter reports the discovery of a cool star with excess brightness in the vacuum ultraviolet on an objective-prism photograph obtained during the second Skylab mission. This star, HD 149499, is of type K0 V and has a companion with an apparent magnitude of about 11.8; the relatively flat UV spectrum observed at the position of HD 149499 is characteristic of a 10th or 11th magnitude unreddened O- or early B-type star. It is shown that the excess VUV brightness is due to the companion, HD 149499B, which probably lies in the region of the H-R diagram occupied by the hot white dwarfs. Inspection of white dwarf lists indicates that this star is the sixth or seventh brightest white dwarf known. A maximum orbital motion of 0.025 arcsec/yr is estimated along with a period of just under 500 yr.

Frequency analysis of the 5.65-min oscillations in the rapidly oscillating Ap star HD 134214

International Nuclear Information System (INIS)

Kreidl, T.J.; Kurtz, D.W.

1986-01-01

High-speed photometric observations of HD 134214 obtained during 35 hr of observation in 1985 from Lowell Observatory and the South African Astronomical Observatory are presented. A frequency analysis of these data indicate the presence of only one frequency of oscillation in this star at f 1 = 2.94960 + - 0.00004 mHz. This is the highest frequency which is demonstrably not a harmonic of a lower frequency yet discovered in a rapidly oscillating Ap star. This frequency is above the critical frequency calculated for A star models by previous authors. The phase shift has been calculated for HD 134214 for simultaneous B and V observations obtained on three nights from Lowell Observatory. (author)

High accuracy results for the energy levels of the molecular ions H+2, D+2 and HD+, up to J = 2

International Nuclear Information System (INIS)

Karr, J Ph; Hilico, L

2006-01-01

We present a nonrelativistic calculation of the rotation-vibration levels of the molecular ions H + 2 , D + 2 and HD + , relying on the diagonalization of the exact three-body Hamiltonian in a variational basis. The J = 2 levels are obtained with a very high accuracy of 10 -14 au (for most levels) representing an improvement by five orders of magnitude over previous calculations. The accuracy is also improved for the J = 1 levels of H + 2 and D + 2 with respect to earlier works. Moreover, we have computed the sensitivities of the energy levels with respect to the mass ratios, allowing these levels to be used for metrological purposes

Extraction and Analysis of Sulfur Mustard (HD) from Various Food Matrices by Gas ChromatographyMass Spectrometry

Science.gov (United States)

2016-01-01

9 8. (a) GC chromatogram and (b) mass spectrum for HD extracted from hot dog; (c) mass spectrum at Rt = 5.08 min (benzoic acid ...shows the mass spectrum for benzoic acid . Percent recoveries were calculated based on an external calibration curve for HD (Figure 14). The recoveries...EXTRACTION AND ANALYSIS OF SULFUR MUSTARD ( HD ) FROM VARIOUS FOOD MATRICES BY GAS CHROMATOGRAPHY–MASS

Test Results of HD1b, an upgraded 16 Tesla Nb3Sn Dipole Magnet

International Nuclear Information System (INIS)

Lietzke, A.F.; Bartlett, S.E.; Bish, P.; Caspi, S.; Dietderich, D.; Ferracin, P.; Gourlay, S.; Hafalia, A.R.; Hannaford, C.R.; Higley, H.; Lau, W.; Liggins, N.; Mattafirri, S.; Nyman, M.; Sabbi, G.; Scanlan, R.; Swanson, J.

2005-01-01

The Superconducting Magnet Group at Lawrence Berkeley National Laboratory has been developing high-field, brittle-superconductor, accelerator magnet technology, in which the conductor's support system can significantly impact conductor performance (as well as magnet training). A recent H-dipole coil test (HD1) achieved a peak bore-field of 16 Tesla, using two, flat-racetrack, double-layer Nb 3 Sn coils. However, its 4.5 K training was slow, with an erratic plateau at ∼92% of its un-degraded ''short-sample'' expectation (∼16.6 T). Quench-origins correlated with regions where low conductor pre-stress had been expected (3-D FEM predictions and variations in 300 K coil-size). The coils were re-assembled with minor coil-support changes and re-tested as ''HD1b'', with a 185 MPa average pre-stress (30 MPa higher than HD1, with a 15-20 MPa pole-turn margin expected at 17 T). Training started higher (15.1 T), and quickly reached a stable, negligibly higher plateau at 16 T. After a thermal cycle, training started at 15.4 T, but peaked at 15.8 T, on the third attempt, before degrading to a 15.7 T plateau. The temperature dependence of this plateau was explored in a sub-atmospheric LHe bath to 3.0 K. Magnet performance data for both thermal cycles is presented and discussed, along with issues for future high-field accelerator magnet development

CHANDRA CHARACTERIZATION OF X-RAY EMISSION IN THE YOUNG F-STAR BINARY SYSTEM HD 113766

Energy Technology Data Exchange (ETDEWEB)

Lisse, C. M. [Planetary Exploration Branch, Space Exploration Sector, Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723 (United States); Christian, D. J. [Department of Physics and Astronomy, California State University Northridge, 18111 Nordhoff Street, Northridge, CA 91330 (United States); Wolk, S. J. [Chandra X-ray Center, Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Günther, H. M. [Massachusetts Institute of Technology, Kavli Institute for Astrophysics and Space Research, 77 Massachusetts Avenue, NE83-569, Cambridge, MA 02139 (United States); Chen, C. H. [STScI, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Grady, C. A., E-mail: carey.lisse@jhuapl.edu, E-mail: damian.christian@csun.edu, E-mail: swolk@cfa.harvard.edu, E-mail: hgunther@mit.edu, E-mail: cchen@stsci.edu, E-mail: carol.a.grady@nasa.gov [Eureka Scientific and Goddard Space Flight Center, Code 667, NASA-GSFC, Greenbelt, MD 20771 (United States)

2017-02-01

Using Chandra , we have obtained imaging X-ray spectroscopy of the 10–16 Myr old F-star binary HD 113766. We individually resolve the 1.″4 separation binary components for the first time in the X-ray and find a total 0.3–2.0 keV luminosity of 2.2 × 10{sup 29} erg s{sup −1}, consistent with previous RASS estimates. We find emission from the easternmost, infrared-bright, dusty member HD 113766A to be only ∼10% that of the western, infrared-faint member HD 113766B. There is no evidence for a 3rd late-type stellar or substellar member of HD 113766 with L {sub x} > 6 × 10{sup 25} erg s{sup −1} within 2′ of the binary pair. The ratio of the two stars’ X-ray luminosity is consistent with their assignments as F2V and F6V by Pecaut et al. The emission is soft for both stars, kT {sub Apec} = 0.30–0.50 keV, suggesting X-rays produced by stellar rotation and/or convection in young dynamos, but not accretion or outflow shocks, which we rule out. A possible 2.8 ± 0.15 (2 σ ) hr modulation in the HD 113766B X-ray emission is seen, but at very low confidence and of unknown provenance. Stellar wind drag models corresponding to L {sub x} ∼ 2 × 10{sup 29} erg s{sup −1} argue for a 1 mm dust particle lifetime around HD 113766B of only ∼90,0000 years, suggesting that dust around HD 113766B is quickly removed, whereas 1 mm sized dust around HD 113766A can survive for >1.5 × 10{sup 6} years. At 10{sup 28}–10{sup 29} erg s{sup −1} X-ray luminosity, astrobiologically important effects, like dust warming and X-ray photolytic organic synthesis, are likely for any circumstellar material in the HD 113766 systems.

The Schooling Experience of Adolescent Boys with AD/HD: An Australian Case Study

Science.gov (United States)

Gibbs, Kathryn; Mercer, K. Louise; Carrington, Suzanne

2016-01-01

This study explored the experience of schooling of six adolescent boys diagnosed with AD/HD from the perspectives of the boys, their mothers and their teachers. The study utilised social constructionism as the theoretical orientation and the Dynamic Developmental Theory (DDT) of AD/HD as the explanatory framework. Utilising a multiple,…

Left and right reaction time differences to the sound intensity in normal and AD/HD children.

Science.gov (United States)

Baghdadi, Golnaz; Towhidkhah, Farzad; Rostami, Reza

2017-06-01

Right hemisphere, which is attributed to the sound intensity discrimination, has abnormality in people with attention deficit/hyperactivity disorder (AD/HD). However, it is not studied whether the defect in the right hemisphere has influenced on the intensity sensation of AD/HD subjects or not. In this study, the sensitivity of normal and AD/HD children to the sound intensity was investigated. Nineteen normal and fourteen AD/HD children participated in the study and performed a simple auditory reaction time task. Using the regression analysis, the sensitivity of right and left ears to various sound intensity levels was examined. The statistical results showed that the sensitivity of AD/HD subjects to the intensity was lower than the normal group (p Left and right pathways of the auditory system had the same pattern of response in AD/HD subjects (p > 0.05). However, in control group the left pathway was more sensitive to the sound intensity level than the right one (p = 0.0156). It can be probable that the deficit of the right hemisphere has influenced on the auditory sensitivity of AD/HD children. The possible existent deficits of other auditory system components such as middle ear, inner ear, or involved brain stem nucleuses may also lead to the observed results. The development of new biomarkers based on the sensitivity of the brain hemispheres to the sound intensity has been suggested to estimate the risk of AD/HD. Designing new technique to correct the auditory feedback has been also proposed in behavioral treatment sessions. Copyright © 2017. Published by Elsevier B.V.

Multi-modal neuroimaging in premanifest and early Huntington's disease: 18 month longitudinal data from the IMAGE-HD study.

Science.gov (United States)

Domínguez D, Juan F; Egan, Gary F; Gray, Marcus A; Poudel, Govinda R; Churchyard, Andrew; Chua, Phyllis; Stout, Julie C; Georgiou-Karistianis, Nellie

2013-01-01

IMAGE-HD is an Australian based multi-modal longitudinal magnetic resonance imaging (MRI) study in premanifest and early symptomatic Huntington's disease (pre-HD and symp-HD, respectively). In this investigation we sought to determine the sensitivity of imaging methods to detect macrostructural (volume) and microstructural (diffusivity) longitudinal change in HD. We used a 3T MRI scanner to acquire T1 and diffusion weighted images at baseline and 18 months in 31 pre-HD, 31 symp-HD and 29 controls. Volume was measured across the whole brain, and volume and diffusion measures were ascertained for caudate and putamen. We observed a range of significant volumetric and, for the first time, diffusion changes over 18 months in both pre-HD and symp-HD, relative to controls, detectable at the brain-wide level (volume change in grey and white matter) and in caudate and putamen (volume and diffusivity change). Importantly, longitudinal volume change in the caudate was the only measure that discriminated between groups across all stages of disease: far from diagnosis (>15 years), close to diagnosis (fractional anisotropy, FA), only longitudinal FA change was sensitive to group differences, but only after diagnosis. These findings further confirm caudate atrophy as one of the most sensitive and early biomarkers of neurodegeneration in HD. They also highlight that different tissue properties have varying schedules in their ability to discriminate between groups along disease progression and may therefore inform biomarker selection for future therapeutic interventions.

High-speed infrared imaging for material characterization in experimental mechanics experiments

Science.gov (United States)

Gagnon, Marc-André; Marcotte, Frédérick; Lagueux, Philippe; Farley, Vincent; Guyot, Éric; Morton, Vince

2017-10-01

Heat transfers are involved in many phenomena such as friction, tensile stress, shear stress and material rupture. Among the challenges encountered during the characterization of such thermal patterns is the need for both high spatial and temporal resolution. Infrared imaging provides information about surface temperature that can be attributed to the stress response of the material and breaking of chemical bounds. In order to illustrate this concept, tensile and shear tests were carried out on steel, aluminum and carbon fiber composite materials and monitored using high-speed (Telops FASTM2K) and high-definition (Telops HD-IR) infrared imaging. Results from split-Hopkinson experiments carried out on a polymer material at high strain-rate are also presented. The results illustrate how high-speed and high-definition infrared imaging in the midwave infrared (MWIR, 3 - 5 μm) spectral range can provide detailed information about the thermal properties of materials undergoing mechanical testing.

Purification and characterization of antifungal compounds from Lactobacillus plantarum HD1 isolated from kimchi.

Science.gov (United States)

Ryu, Eun Hye; Yang, Eun Ju; Woo, Eun Rhan; Chang, Hae Choon

2014-08-01

Strain HD1 with antifungal activity was isolated from kimchi and identified as Lactobacillus plantarum. Antifungal compounds from Lb. plantarum HD1 were active against food- and feed-borne filamentous fungi and yeasts in a spot-on-the-lawn assay. Antifungal activity of Lb. plantarum HD1 was stronger against filamentous fungi than yeast. Antifungal compounds were purified using solid phase extraction (SPE) and recycling preparative-HPLC. Structures of the antifungal compounds were elucidated by electrospray ionization-mass spectrometry and nuclear magnetic resonance. Active compounds from Lb. plantarum HD1 were identified as 5-oxododecanoic acid (MW 214), 3-hydroxy decanoic acid (MW 188), and 3-hydroxy-5-dodecenoic acid (MW 214). To investigate the potential application of these antifungal compounds for reduction of fungal spoilage in foods, Korean draft rice wine was used as a food model. White film-forming yeasts were observed in control draft rice wine after 11 days of incubation. However, film-forming yeasts were not observed in draft rice wine treated with SPE-prepared culture supernatant of Lb. plantarum HD1 (equivalent to 2.5% addition of culture supernatant) until 27 days of incubation. The addition of antifungal compounds to Korean draft rice wine extended shelf-life up to 27 days at 10 °C without any sterilization process. Therefore, the antifungal activity of Lb. plantarum HD1 may lead to the development of powerful biopreservative systems capable of preventing food- and feed-borne fungal spoilage. Copyright © 2014 Elsevier Ltd. All rights reserved.

Discovery of multiple pulsations in the new δ Scuti star HD 92277: Asteroseismology from Dome A, Antarctica

International Nuclear Information System (INIS)

Zong, Weikai; Fu, Jian-Ning; Niu, Jia-Shu; Zhu, Zonghong; Charpinet, S.; Vauclair, G.; Ashley, Michael C. B.; Lawrence, Jon S.; Luong-Van, Daniel; Cui, Xiangqun; Gong, Xuefei; Feng, Longlong; Wang, Lifan; Yuan, Xiangyan; Zhu, Zhenxi; Liu, Qiang; Wang, Lingzhi; Zhou, Xu; Pennypacker, Carl R.; York, Donald G.

2015-01-01

We report the discovery of low-amplitude oscillations in the star HD 92277 from long, continuous observations in the r and g bands using the CSTAR telescopes in Antarctica. A total of more than 1950 hours of high-quality light curves were used to categorize HD 92277 as a new member of the δ Scuti class. We have detected 21 (20 frequencies are independent and one is the linear combination) and 14 (13 frequencies are independent and one is the linear combination) pulsation frequencies in the r and g bands, respectively, indicating a multi-periodic pulsation behavior. The primary frequency f 1 = 10.810 days −1 corresponds to a period of 0.0925 days and is an l = 1 mode. We estimate a B − V index of 0.39 and derive an effective temperature of 6800 K for HD 92277. We conclude that long, continuous and uninterrupted time-series photometry can be performed from Dome A, Antarctica, and that this is especially valuable for asteroseismology where multi-color observations (often not available from space-based telescopes) assist with mode identification.

Autism-relevant traits interact with temporoparietal junction stimulation effects on social cognition: a high-definition transcranial direct current stimulation and electroencephalography study.

Science.gov (United States)

Donaldson, Peter H; Kirkovski, Melissa; Rinehart, Nicole J; Enticott, Peter G

2018-03-01

The temporoparietal junction (TPJ) is implicated in mental and emotional state attribution, processes associated with autism-relevant traits. Transcranial direct current stimulation (tDCS) to the TPJ can influence social-cognitive performance. However, associations with electrophysiology and autism-relevant traits remain relatively unexamined. This study had two aims: first, exploring links between Autism-Spectrum Quotient (AQ) scores and social-cognitive performance; second, examining interactions between AQ scores and high-definition-tDCS (HD-tDCS) applied to the right TPJ in terms of mental/emotional state attribution and neurophysiological outcomes. Fifty-three participants completed mental/emotional state attribution tasks before and after HD-tDCS. Pre-stimulation mental state attribution accuracy was reduced in participants with higher AQ Switching scores. Cathodal stimulation was associated with reduced emotion attribution performance in participants with higher AQ Switching and AQ Social scores (the latter at trend-level). Anodal stimulation more frequently interacted with AQ Social scores in terms of neurophysiology, in particular regarding reduced delta power in the left compared to right TPJ, and trend-level positive interactions with P100 and P300 latencies during the emotion recognition task. Elements of attention/switching (AQ Switching) may subserve or underpin elements of social cognition (AQ Social), and cathodal and anodal stimulation may have differing effects depending on trait levels in these domains. This study makes an important and original contribution in terms of increasing understanding of how such trait-level variation might interact with the effects of tDCS and also extending previous studies with regard to understanding potential roles of the rTPJ in both attention and social cognition and how autism-relevant traits might influence TPJ function. © 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

The discovery of 13.72-min oscillations in the cool magnetic Ap star HD 217522

International Nuclear Information System (INIS)

Kurtz, D.W.

1983-01-01

The discovery is announced of oscillations with a period near 13.72 min in the cool magnetic Ap star HD 217522. 97 hr of high-speed photometric observations are presented, obtained on 18 nights spread over a time span of 74 days in 1982. The amplitude of the oscillations in HD 217522 is variable from night to night and also on a longer time-scale. A frequency analysis of the data identifies the principal frequency of oscillation to be 4.37435+-0.00014 hr -1 . Because of the complexities of the amplitude modulation of the light curve and the very low amplitude of the light variations, the data are insufficient for a complete frequency solution. This star is the seventh member of the class of rapidly oscillating Ap stars. (author)

Multi-modal neuroimaging in premanifest and early Huntington's disease: 18 month longitudinal data from the IMAGE-HD study.

Directory of Open Access Journals (Sweden)

Juan F Domínguez D

Full Text Available IMAGE-HD is an Australian based multi-modal longitudinal magnetic resonance imaging (MRI study in premanifest and early symptomatic Huntington's disease (pre-HD and symp-HD, respectively. In this investigation we sought to determine the sensitivity of imaging methods to detect macrostructural (volume and microstructural (diffusivity longitudinal change in HD. We used a 3T MRI scanner to acquire T1 and diffusion weighted images at baseline and 18 months in 31 pre-HD, 31 symp-HD and 29 controls. Volume was measured across the whole brain, and volume and diffusion measures were ascertained for caudate and putamen. We observed a range of significant volumetric and, for the first time, diffusion changes over 18 months in both pre-HD and symp-HD, relative to controls, detectable at the brain-wide level (volume change in grey and white matter and in caudate and putamen (volume and diffusivity change. Importantly, longitudinal volume change in the caudate was the only measure that discriminated between groups across all stages of disease: far from diagnosis (>15 years, close to diagnosis (<15 years and after diagnosis. Of the two diffusion metrics (mean diffusivity, MD; fractional anisotropy, FA, only longitudinal FA change was sensitive to group differences, but only after diagnosis. These findings further confirm caudate atrophy as one of the most sensitive and early biomarkers of neurodegeneration in HD. They also highlight that different tissue properties have varying schedules in their ability to discriminate between groups along disease progression and may therefore inform biomarker selection for future therapeutic interventions.

Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16

Science.gov (United States)

Djoussé, Luc; Knowlton, Beth; Hayden, Michael R.; Almqvist, Elisabeth W.; Brinkman, Ryan R.; Ross, Christopher A.; Margolis, Russel L.; Rosenblatt, Adam; Durr, Alexandra; Dode, Catherine; Morrison, Patrick J.; Novelletto, Andrea; Frontali, Marina; Trent, Ronald J. A.; McCusker, Elizabeth; Gómez-Tortosa, Estrella; Mayo Cabrero, David; Jones, Randi; Zanko, Andrea; Nance, Martha; Abramson, Ruth K.; Suchowersky, Oksana; Paulsen, Jane S.; Harrison, Madaline B.; Yang, Qiong; Cupples, L. Adrienne; Mysore, Jayalakshmi; Gusella, James F.; MacDonald, Marcy E.

2007-01-01

Huntington disease (HD) is a neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the HD gene on chromosome 4p16.3. A recent genome scan for genetic modifiers of age at onset of motor symptoms (AO) in HD suggests that one modifier may reside in the region close to the HD gene itself. We used data from 535 HD participants of the New England Huntington cohort and the HD MAPS cohort to assess whether AO was influenced by any of the three markers in the 4p16 region: MSX1 (Drosophila homeo box homologue 1, formerly known as homeo box 7, HOX7), Δ2642 (within the HD coding sequence), and BJ56 (D4S127). Suggestive evidence for an association was seen between MSX1 alleles and AO, after adjustment for normal CAG repeat, expanded repeat, and their product term (model P value 0.079). Of the variance of AO that was not accounted for by HD and normal CAG repeats, 0.8% could be attributed to the MSX1 genotype. Individuals with MSX1 genotype 3/3 tended to have younger AO. No association was found between Δ2642 (P=0.44) and BJ56 (P=0.73) and AO. This study supports previous studies suggesting that there may be a significant genetic modifier for AO in HD in the 4p16 region. Furthermore, the modifier may be present on both HD and normal chromosomes bearing the 3 allele of the MSX1 marker. PMID:15029481

The peculiar A star HD 110066: a photographic region line identification study

International Nuclear Information System (INIS)

Adelman, S.J.

1988-01-01

A line identification study of the very sharp-lined peculiar A star HD 110066 has been performed using four high dispersion photographic region spectrograms. New species found include Al I, Si I, S II, Ti I, Co II, Zr II, Cd I, La II, Ce III, Gd III, Dy II, Er II and Tm II. The presence of these species is in accord with the continuity of the magnetic Ap star sequence. (author)

Classroon demonstration: Foucault s currents explored by the computer hard disc (HD

Directory of Open Access Journals (Sweden)

Jorge Roberto Pimentel

2008-09-01

Full Text Available This paper making an experimental exploration of Foucault s currents (eddy currents through a rotor magnetically coupled to computer hard disc (HD that is no longer being used. The set-up allows to illustrate in a stimulating way electromagnetism classes in High Schools for mean of the qualitative observations of the currents which are created as consequence of the movement of an electric conductor in a region where a magnetic field exists.

The TERMS Project: Improved Orbital Parameters and Photometry of HD168443 and the Photometry Pipeline

Science.gov (United States)

Pilyavsky, Genady; Mahadevan, S.; Kane, S. R.; Howard, A. W.; Ciardi, D. R.; de Pree, C.; Dragomir, D.; Fischer, D.; Henry, G. W.; Jensen, E. L. N.; Laughlin, G.; Marlowe, H.; Rabus, M.; von Braun, K.; Wright, J. T.; Wang, X.

2012-01-01

The discovery of transiting planets around bright stars holds the potential to greatly enhance our understanding of planetary atmospheres. The Transit Ephemeris Refinement and Monitoring Survey (TERMS) project focuses on updating the ephemerides of known exoplanets, put tighter constraints on the orbital parameters and shrink the large errors on the predicted transit windows, enabling photometric monitoring to search for a transit signature. Here, we present the revised orbital parameters and the photometric coverage during a predicted transit window of HD168443b, a massive planet orbiting the bright star HD 168443 (V = 6.92) with a period of 58.11 days. The high eccentricity of the planetary orbit (e = 0.53) significantly enhances the a-priori transit probability (3.7%) from what is expected for a circular orbit (2.5%). The transit ephemeris was updated using refined orbital parameters from additional Keck-HIRES radial velocities. The photometry obtained at the 1 m telescope in Cerro Tololo Inter-American Observatory (CTIO) and the T8 0.8 m Automated Photometric Telescope (APT) at Fairborn Observatory achieved the necessary millimag precision. The expected change in flux (0.5%) for HD168443 was not observed during the predicted transit window, thus allowing us to rule out the transit and put tighter constrains on the orbital inclination of HD168443b. Additionally, we present the software used to analyze the CTIO data. Developed by the TERMS team, this IDL based package is a fast, precise, and easy to use program which has eliminated the need for external software and command line prompts by utilizing the functionality of a graphical user interface (GUI).

Water vapor in the spectrum of the extrasolar planet HD 189733b. II. The eclipse

Energy Technology Data Exchange (ETDEWEB)

Crouzet, Nicolas [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, Ontario M5S 3H4 (Canada); McCullough, Peter R. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Madhusudhan, Nikku, E-mail: crouzet@dunlap.utoronto.ca [Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA (United Kingdom)

2014-11-10

Spectroscopic observations of exoplanets are crucial to infer the composition and properties of their atmospheres. HD 189733b is one of the most extensively studied exoplanets and is a cornerstone for hot Jupiter models. In this paper, we report the dayside emission spectrum of HD 189733b in the wavelength range 1.1-1.7 μm obtained with the Hubble Space Telescope Wide Field Camera 3 (WFC3) in spatial scan mode. The quality of the data is such that even a straightforward analysis yields a high-precision Poisson noise-limited spectrum: the median 1σ uncertainty is 57 ppm per 0.02 μm bin. We also build a white-light curve correcting for systematic effects and derive an absolute eclipse depth of 96 ± 39 ppm. The resulting spectrum shows marginal evidence for water vapor absorption, but can also be well explained by a blackbody spectrum. However, the combination of these WFC3 data with previous Spitzer photometric observations is best explained by a dayside atmosphere of HD 189733b with no thermal inversion and a nearly solar or subsolar H{sub 2}O abundance in a cloud-free atmosphere. Alternatively, this apparent subsolar abundance may be the result of clouds or hazes that future studies need to investigate.

Brief historical perspective on the definition of high-level nuclear wastes

International Nuclear Information System (INIS)

Jacobs, D.G.; Szluha, A.T.; Gablin, K.A.; Croff, A.G.

1985-03-01

This report constitutes a historical perspective on the definition of HLW with emphasis on the US situation. The major HLW definitions are summarized chronologically, including a categorization of the considerations (e.g., waste source, heat generation rate, radiological effects) forming the bases of the definitions. High-level waste (HLW) definitions are then discussed in terms of these considerations. A brief discussion of the institutional aspects of HLW regulation and management are presented. An appendix to the report constitutes an annotated, chronological bibliography that formed the basis of the perspective

The role of three-dimensional high-definition laparoscopic surgery for gynaecology.

Science.gov (United States)

Usta, Taner A; Gundogdu, Elif C

2015-08-01

This article reviews the potential benefits and disadvantages of new three-dimensional (3D) high-definition laparoscopic surgery for gynaecology. With the new-generation 3D high-definition laparoscopic vision systems (LVSs), operation time and learning period are reduced and procedural error margin is decreased. New-generation 3D high-definition LVSs enable to reduce operation time both for novice and experienced surgeons. Headache, eye fatigue or nausea reported with first-generation systems are not different than two-dimensional (2D) LVSs. The system's being more expensive, having the obligation to wear glasses, big and heavy camera probe in some of the devices are accounted for negative aspects of the system that need to be improved. Depth loss in tissues in 2D LVSs and associated adverse events can be eliminated with 3D high-definition LVSs. By virtue of faster learning curve, shorter operation time, reduced error margin and lack of side-effects reported by surgeons with first-generation systems, 3D LVSs seem to be a strong competition to classical laparoscopic imaging systems. Thanks to technological advancements, using lighter and smaller cameras and monitors without glasses is in the near future.

High-contrast imaging of the close environment of HD 142527. VLT/NaCo adaptive optics thermal and angular differential imaging

Science.gov (United States)

Rameau, J.; Chauvin, G.; Lagrange, A.-M.; Thébault, P.; Milli, J.; Girard, J. H.; Bonnefoy, M.

2012-10-01

Context. It has long been suggested that circumstellar disks surrounding young stars may be the signposts of planets, and even more so since the recent discoveries of embedded substellar companions. According to models, the planet-disk interaction may create large structures, gaps, rings, or spirals in the disk. In that sense, the Herbig star HD 142527 is particularly compelling, as its massive disk displays intriguing asymmetries that suggest the existence of a dynamical peturber of unknown nature. Aims: Our goal was to obtain deep thermal images of the close circumstellar environment of HD 142527 to re-image the reported close-in structures (cavity, spiral arms) of the disk and to search for stellar and substellar companions that could be connected to their presence. Methods: We obtained high-contrast images with the NaCo adaptive optics system at the Very Large Telescope in L'-band. We applied different analysis strategies using both classical PSF-subtraction and angular differential imaging to probe for any extended structures or point-like sources. Results: The circumstellar environment of HD 142527 is revealed at an unprecedented spatial resolution down to the subarcsecond level for the first time at 3.8 μm. Our images reveal important radial and azimuthal asymmetries that invalidate an elliptical shape for the disk. It instead suggests a bright inhomogeneous spiral arm plus various fainter spiral arms. We also confirm an inner cavity down to 30 AU and two important dips at position angles of 0 and 135 deg. The detection performance in angular differential imaging enables exploration of the planetary mass regime for projected physical separations as close as 40 AU. Use of our detection map together with Monte Carlo simulations sets stringent constraints on the presence of planetary mass, brown dwarf or stellar companions as a function of the semi-major axis. They severely limit any presence of massive giant planets with semi-major axis beyond 50 AU, i

HD 179821 (V1427 Aql, IRAS 19114+0002) - a massive post-red supergiant star?

Science.gov (United States)

Şahin, T.; Lambert, David L.; Klochkova, Valentina G.; Panchuk, Vladimir E.

2016-10-01

We have derived elemental abundances of a remarkable star, HD 179821, with unusual composition (e.g. [Na/Fe] = 1.0 ± 0.2 dex) and extra-ordinary spectral characteristics. Its metallicity at [Fe/H] = 0.4 dex places it among the most metal-rich stars yet analysed. The abundance analysis of this luminous star is based on high-resolution and high-quality (S/N ≈ 120-420) optical echelle spectra from McDonald Observatory and Special Astronomy Observatory. The data includes five years of observations over 21 epochs. Standard 1D local thermodynamic equilibrium analysis provides a fresh determination of the atmospheric parameters over all epochs: Teff = 7350 ± 200 K, log g= +0.6 ± 0.3, and a microturbulent velocity ξ = 6.6 ± 1.6 km s-1 and [Fe/H] = 0.4 ± 0.2, and a carbon abundance [C/Fe] = -0.19 ± 0.30. We find oxygen abundance [O/Fe] = -0.25 ± 0.28 and an enhancement of 0.9 dex in N. A supersonic macroturbulent velocity of 22.0 ± 2.0 km s-1 is determined from both strong and weak Fe I and Fe II lines. Elemental abundances are obtained for 22 elements. HD 179821 is not enriched in s-process products. Eu is overabundant relative to the anticipated [X/Fe] ≈ 0.0. Some peculiarities of its optical spectrum (e.g. variability in the spectral line shapes) is noticed. This includes the line profile variations for H α line. Based on its estimated luminosity, effective temperature and surface gravity, HD 179821 is a massive star evolving to become a red supergiant and finally a Type II supernova.

ACCRETION KINEMATICS THROUGH THE WARPED TRANSITION DISK IN HD 142527 FROM RESOLVED CO(6–5) OBSERVATIONS

Energy Technology Data Exchange (ETDEWEB)

Casassus, S.; Marino, S.; Pérez, S.; Plas, G. van der; Christiaens, V.; Montesinos, Matías [Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago (Chile); Roman, P.; Dunhill, A.; Cuadra, J.; Cieza, L.; Moral, Victor [Millennium Nucleus “Protoplanetary Disks,” Chile (Chile); Armitage, P. J. [JILA, University of Colorado and NIST, UCB 440, Boulder, CO 80309 (United States); Wootten, A., E-mail: scasassus@u.uchile.cl [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903-2475 (United States)

2015-10-01

The finding of residual gas in the large central cavity of the HD 142527 disk motivates questions regarding the origin of its non-Keplerian kinematics and possible connections with planet formation. We aim to understand the physical structure that underlies the intra-cavity gaseous flows, guided by new molecular-line data in CO(6–5) with unprecedented angular resolutions. Given the warped structure inferred from the identification of scattered-light shadows cast on the outer disk, the kinematics are consistent, to first order, with axisymmetric accretion onto the inner disk occurring at all azimuths. A steady-state accretion profile, fixed at the stellar accretion rate, explains the depth of the cavity as traced in CO isotopologues. The abrupt warp and evidence for near free-fall radial flows in HD 142527 resemble theoretical models for disk tearing, which could be driven by the reported low-mass companion, whose orbit may be contained in the plane of the inner disk. The companion’s high inclination with respect to the massive outer disk could drive Kozai oscillations over long timescales; high-eccentricity periods may perhaps account for the large cavity. While shadowing by the tilted disk could imprint an azimuthal modulation in the molecular-line maps, further observations are required to ascertain the significance of azimuthal structure in the density field inside the cavity of HD 142527.

The comparison of high and standard definition computed ...

African Journals Online (AJOL)

The comparison of high and standard definition computed tomography techniques regarding coronary artery imaging. A Aykut, D Bumin, Y Omer, K Mustafa, C Meltem, C Orhan, U Nisa, O Hikmet, D Hakan, K Mert ...

Permeation of a H2 + HD + D2 gas mixture through a polymer membrane

International Nuclear Information System (INIS)

Mercea, P.; Cuna, S.; Kreibik, S.; Ursu, I.

1990-01-01

The selective permeation of a H 2 + HD + D 2 gas mixture through a polyethylene terephthalate membrane was studied at T 20 0 C. It was found that the permeation of the HD through the membrane leads to a smaller overall hydrogen-deuterium separation factor than that determined in the permeation experiments with pure H 2 and D 2 . On the other hand, a process of isotopic exchange between deuterium atoms from the penetrant gas stream and hydrogen atoms from the polymer membrane is assumed and discussed in order to explain temporal variations of the H 2 , HD and D 2 concentrations of the permanent gas stream. (author)

PHOTOELECTRIC OBSERVATIONS OF HD 8358

Directory of Open Access Journals (Sweden)

Woo-Baik Lee

1989-06-01

Full Text Available UBV photoelectric observations of RS CVn type variable star HD 8358 were made using the 61cm reflector at Sobaeksan Astronomical Observatory. The data were obtained on 15 nights from October 1987 to December 1988. Double peaks of maximum light is seen from the light curve and continuous change of phase in notified from the times of maximum lights. The colors of October, 1987 - January, 1988 observations are bluer in ∆(b-u, but redder in ∆(u-b, than those of November -December, 1988 observations.

α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome

Directory of Open Access Journals (Sweden)

Mayim E. Wiens

2017-01-01

Full Text Available α-Defensins are an important class of abundant innate immune effectors that are potently antiviral against a number of nonenveloped viral pathogens; however, a common mechanism to explain their ability to block infection by these unrelated viruses is lacking. We previously found that human defensin 5 (HD5 blocks a critical host-mediated proteolytic processing step required for human papillomavirus (HPV infection. Here, we show that bypassing the requirement for this cleavage failed to abrogate HD5 inhibition. Instead, HD5 altered HPV trafficking in the cell. In the presence of an inhibitory concentration of HD5, HPV was internalized and reached the early endosome. The internalized capsid became permeable to antibodies and proteases; however, HD5 prevented dissociation of the viral capsid from the genome, reduced viral trafficking to the trans-Golgi network, redirected the incoming viral particle to the lysosome, and accelerated the degradation of internalized capsid proteins. This mechanism is equivalent to the mechanism by which HD5 inhibits human adenovirus. Thus, our data support capsid stabilization and redirection to the lysosome during infection as a general antiviral mechanism of α-defensins against nonenveloped viruses.

HD 208905: um sistema múltiplo de estrelas quentes

Science.gov (United States)

Candeias, J. P.; Daflon, S.; Cunha, K.

2003-08-01

Durante o survey de associações OB do disco Galáctico, foi constatada a multiplicidade do sistema HD 208905, pertencentes à associação de Cep OB2. Este objeto está classificado como uma estrela pertencente a um sistema múltiplo, com magnitude mv = 7.0 e tipo espectral B1V. De fato, os espectros de HD 208905 apresentam perfis de absorção triplicados. Dois dos perfis são bastante similares entre si, e são estreitos e bem definidos, sugerindo que as velocidades rotacionais projetadas (v sin i) das duas estrelas são baixas. Os espectros obtidos também apresentam perfis mais alargados que poderiam ser atribuídos a uma terceira componente estelar com v sin i mais alto. A análise de HD 208905 é baseada no estudo da variação da posição relativa dos perfis espectrais de acordo com a fase do sistema. Nossos dados observacionais são um conjunto de espectros de alta resolução obtidos no McDonald Observatory (Universidade do Texas, Austin), Kitt Peak National Observatory e Palomar Observatory, cobrindo o período de 10/91 até 12/95. Inicialmente, calculamos a velocidade radial de cada componente do sistema, considerando o desvio Doppler sofrido por cada estrela. As velocidades radiais medidas foram, em seguida, corrigidas para velocidades radiais heliocêntricas. O passo seguinte constituiu na determinação da periodicidade da série temporal definida pelas medidas das velocidades radiais heliocêntricas através da análise de Fourier. A nossa base de dados não permitiu definir uma solução única para o sistema HD 208905. As possíveis soluções encontradas têm períodos entre 1 e 27 dias e serão apresentadas e discutidas.

Interocular symmetry of retinal nerve fiber layer and optic nerve head parameters measured by Cirrus high-definition optical coherence tomography in a normal pediatric population.

Science.gov (United States)

Pawar, Neelam; Maheshwari, Devendra; Ravindran, Meenakshi; Ramakrishnan, Renagappa

2017-10-01

To determine interocular differences in the retinal nerve fiber layer (RNFL) and optic nerve head (ONH) parameters in a pediatric population using Cirrus high-definition optical coherence tomography (HD-OCT). Seventy normal Indian children aged 5-17 years presenting to the Pediatric Clinic were included in this observational cross-sectional study. All subjects underwent a comprehensive ophthalmologic examination and an evaluation of the RNFL and ONH by Cirrus HD-OCT. Differences between the right and left eyes were calculated and values were compared by means of a paired t-test. Subjects were also divided into two groups based on age (under or over 10 years of age). Interocular differences in RNFL and ONH parameters together with sex and age variations for these differences were determined. The mean age of studied pediatric population was 11.83 ± 3.3 years (range 5-17). Average RNFL thickness was 94.46 ± 8.7 μm (± SD) (range 77-111). Differences in the average RNFL between right and left eyes were not statistically significant (P = 0.060). Superior quadrant RNFL was thicker in the left eye and temporal quadrant was thicker in the right eye. Among ONH parameters, there were no statistically significant differences in any parameters, except vertical cup-disc (CD) ratio which was significant (P = 0.007). The 2.5%-97.5% limits of asymmetry were 9 μm for average RNFL, 0.14 for average CD ratio, and 0.22 for vertical CD ratio. Mean interocular RNFL thickness differences in superior, superior nasal, and temporal superior quadrants were 10.61 (P sex, while only significant differences with age were observed in 12 clock hour sector analysis, mainly in nasal inferior and inferior quadrant. We report the degree of interocular symmetry of RNFL and ONH parameters measured by Cirrus HD-OCT in a healthy pediatric population. The normal interocular RNFL asymmetry should not exceed 9 μm and vertical CD ratio beyond 0.22 should be considered for further investigations. The

Achievement of transportable polarized D, in solid HD, with a one day passively maintained polarization

International Nuclear Information System (INIS)

Honig, A.; Alexander, N.; Fan, Q.; Wei, X.; Yu, Y.Y.

1993-01-01

At a previous workshop, we discussed evaporating solid HD with spin-polarized deuterons to produce a high density polarized deuteron gaseous internal target. Since then, we have achieved in solid HD 38% polarized D, whose spin-lattice relaxation time at 1.5 K in a field of 0.1 T is of the order of a day. Optimization of the procedure with the present apparatus should result in 60% D polarization, and longer polarization holding times. The polarized sample of approximately 0.2 cm 3 volume used here is extractable from the dilution refrigerator with a cold-transfer apparatus which maintains the sample at or below 5 K, insuring retention of the high polarization. It is subsequently insertable into a variety of systems, and employable as a polarized solid, liquid, or gas. We are exploring the possibility of extending the polarization maintenance time to about a month (with a matched 1 month preparation time), of polarizing metastably H as well as D, and of producing much larger samples, of the order of 100 cm 3

Cold quantum-controlled rotationally inelastic scattering of HD with H2 and D2 reveals collisional partner reorientation

Science.gov (United States)

Perreault, William E.; Mukherjee, Nandini; Zare, Richard N.

2018-05-01

Molecular interactions are best probed by scattering experiments. Interpretation of these studies has been limited by lack of control over the quantum states of the incoming collision partners. We report here the rotationally inelastic collisions of quantum-state prepared deuterium hydride (HD) with H2 and D2 using a method that provides an improved control over the input states. HD was coexpanded with its partner in a single supersonic beam, which reduced the collision temperature to 0-5 K, and thereby restricted the involved incoming partial waves to s and p. By preparing HD with its bond axis preferentially aligned parallel and perpendicular to the relative velocity of the colliding partners, we observed that the rotational relaxation of HD depends strongly on the initial bond-axis orientation. We developed a partial-wave analysis that conclusively demonstrates that the scattering mechanism involves the exchange of internal angular momentum between the colliding partners. The striking differences between H2/HD and D2/HD scattering suggest the presence of anisotropically sensitive resonances.

Calculation of the inter-nuclei separation of HD+

International Nuclear Information System (INIS)

Zhu Zhousen; Shi Miangong; Tang Ayou; Yang Baifang; Miao Jingwei

1993-01-01

With the Ritz variational principle, the authors calculate the inter nuclei separation of the HD + molecular ion, and introduces a method to calculate the inter nuclei separations of other simple non-symmetry two-atom molecular ions. One way to work out the trial wave function is provided

Observation of the v′=8←v=0 vibrational overtone in cold trapped HD +

NARCIS (Netherlands)

J.C.J. Koelemeij; D.W.E. Noom; D. de Jong; M.A. Haddad; W. Ubachs

2011-01-01

textabstractWe report the observation of the hitherto undetected v′=8←v=0 vibrational overtone in trapped HD+molecular ions, sympathetically cooled by laser-cooled Be+ions. The overtone is excited using 782 nm laser radiation, after which HD+ions in v=8 are photodissociated by the 313 nm laser used

HD 140283: A Star in the Solar Neighborhood that Formed Shortly after the Big Bang

Science.gov (United States)

Bond, Howard E.; Nelan, Edmund P.; VandenBerg, Don A.; Schaefer, Gail H.; Harmer, Dianne

2013-03-01

HD 140283 is an extremely metal-deficient and high-velocity subgiant in the solar neighborhood, having a location in the Hertzsprung-Russell diagram where absolute magnitude is most sensitive to stellar age. Because it is bright, nearby, unreddened, and has a well-determined chemical composition, this star avoids most of the issues involved in age determinations for globular clusters. Using the Fine Guidance Sensors on the Hubble Space Telescope, we have measured a trigonometric parallax of 17.15 ± 0.14 mas for HD 140283, with an error one-fifth of that determined by the Hipparcos mission. Employing modern theoretical isochrones, which include effects of helium diffusion, revised nuclear reaction rates, and enhanced oxygen abundance, we use the precise distance to infer an age of 14.46 ± 0.31 Gyr. The quoted error includes only the uncertainty in the parallax, and is for adopted surface oxygen and iron abundances of [O/H] = -1.67 and [Fe/H] = -2.40. Uncertainties in the stellar parameters and chemical composition, especially the oxygen content, now contribute more to the error budget for the age of HD 140283 than does its distance, increasing the total uncertainty to about ±0.8 Gyr. Within the errors, the age of HD 140283 does not conflict with the age of the Universe, 13.77 ± 0.06 Gyr, based on the microwave background and Hubble constant, but it must have formed soon after the big bang. Based in part on observations made with the NASA/ESA Hubble Space Telescope, obtained by the Space Telescope Science Institute. STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.

76 FR 2277 - List of Approved Spent Fuel Storage Casks: NUHOMS® HD System Revision 1

Science.gov (United States)

2011-01-13

... Fuel Storage Casks: NUHOMS[supreg] HD System Revision 1 AGENCY: Nuclear Regulatory Commission. ACTION... System listing within the ``List of Approved Spent Fuel Storage Casks'' to include Amendment No. 1 to... the NUHOMS[supreg] HD Horizontal Modular Storage System for Irradiated Nuclear Fuel. [[Page 2279...

Discovery of multiple pulsations in the new δ Scuti star HD 92277: Asteroseismology from Dome A, Antarctica

Energy Technology Data Exchange (ETDEWEB)

Zong, Weikai; Fu, Jian-Ning; Niu, Jia-Shu; Zhu, Zonghong [Department of Astronomy, Beijing Normal University, Beijing 100875 (China); Charpinet, S.; Vauclair, G. [Université de Toulouse, UPS-OMP, IRAP, F-31400 Toulouse (France); Ashley, Michael C. B.; Lawrence, Jon S.; Luong-Van, Daniel [School of Physics, University of New South Wales, Sydney, NSW 2052 (Australia); Cui, Xiangqun; Gong, Xuefei [Nanjing Institute of Astronomical Optics and Technology, Nanjing 210042 (China); Feng, Longlong; Wang, Lifan; Yuan, Xiangyan; Zhu, Zhenxi [Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China); Liu, Qiang; Wang, Lingzhi; Zhou, Xu [National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Pennypacker, Carl R. [Center for Astrophysics, Lawrence Berkeley National Laboratory, Berkeley, CA (United States); York, Donald G., E-mail: jnfu@bnu.edu.cn [Department of Astronomy and Astrophysics and Enrico Fermi Institute, University of Chicago, Chicago, IL 60637 (United States)

2015-02-01

We report the discovery of low-amplitude oscillations in the star HD 92277 from long, continuous observations in the r and g bands using the CSTAR telescopes in Antarctica. A total of more than 1950 hours of high-quality light curves were used to categorize HD 92277 as a new member of the δ Scuti class. We have detected 21 (20 frequencies are independent and one is the linear combination) and 14 (13 frequencies are independent and one is the linear combination) pulsation frequencies in the r and g bands, respectively, indicating a multi-periodic pulsation behavior. The primary frequency f{sub 1} = 10.810 days{sup −1} corresponds to a period of 0.0925 days and is an l = 1 mode. We estimate a B − V index of 0.39 and derive an effective temperature of 6800 K for HD 92277. We conclude that long, continuous and uninterrupted time-series photometry can be performed from Dome A, Antarctica, and that this is especially valuable for asteroseismology where multi-color observations (often not available from space-based telescopes) assist with mode identification.

Nanodiamonds around HD 97048 and Elias 1

NARCIS (Netherlands)

Van Kerckhoven, C; Tielens, AGGM; Waelkens, C

We present an analysis of ISO-SWS observations of the Herbig Ae/Be stars HD 97048 and Elias 1. Besides the well-known family of IR emission bands at 3.3, 6.2, "7.7", 8.6 and 11.2 mum these objects show strong, peculiar emission features at 3.43 and 3.53 mum. The latter two features show pronounced

The Reality of Living with AD/HD: Children's Concern about Educational and Medical Support

Science.gov (United States)

Hughes, Lesley

2007-01-01

A diagnosis of AD/HD may tell us that the child has the core characteristics of inattentiveness, impulsivity and or hyperactivity, but it fails to convey the extent to which the social context of the child's environment manipulates these characteristics. This article reports on how children with a diagnosis of AD/HD view the impact their social…

Ultraviolet anomalies of the WASP-12 and HD 189733 systems: Trojan satellites as a plasma source

Science.gov (United States)

Kislyakova, Kristina; Pilat-Lohinger, Elke; Funk, Barbara; Lammer, Helmut; Fossati, Luca; Eggl, Siegfried; Schwarz, Richard; Boudyada, Mohammed; Erkaev, Nikolai

2017-04-01

We suggest an additional possible plasma source in the WASP-12 and HD189733b systems to explain part of the phenomena observed in ultraviolet (UV) light curves during planetary transits. In the proposed scenario, material originates from the molten surface of Trojan satellites on orbits near the Lagrange points L4 and L5. We show that the temperature at the orbital location of WASP-12b is high enough to melt the surface of rocky Trojans and to form shallow lava oceans on them. At the orbital distance of WASP-12b, this leads to the release of elements such as Mg and Ca, which are expected to surround the system. The predicted Mg and Ca outgassing rates from two Io-sized WASP-12b Trojans are ≈ 2.2 × 1027 s-1 and ≈ 2.2 × 1026 s-1, respectively. Trojan outgassing can lead to the observed lack of emission in MgII h&k and CaII H&K line cores of WASP-12. For HD 189733b, the mechanism is only marginally possible due to the lower temperature. The early ingress of HD 189733b observed in the far-UV (FUV) CII doublet couldn't be explained by this mechanism due to absence of carbon within elements outgassed by molten lava. We investigate the long-term stability region of WASP-12b and HD 189733b in case of planar and inclined motion of these satellites and show that unlike the classical exomoons orbiting the planet, Io-sized Trojans can be stable for the whole systems life time.

Asymmetric H-D exchange reactions of fluorinated aromatic ketones

KAUST Repository

Zhao, Yujun; Lim, XiaoZhi; Pan, Yuanhang; Zong, Lili; Feng, Wei; Tan, Choonhong; Huang, Kuo-Wei

2012-01-01

Chiral bicyclic guanidine catalyzes the asymmetric H-D exchange reactions. Up to 30% ee was achieved. DFT calculations were employed to elucidate and explain the origin of the reaction's stereoselectivity. © 2012 The Royal Society of Chemistry.

75 FR 24786 - List of Approved Spent Fuel Storage Casks: NUHOMS® HD System Revision 1

Science.gov (United States)

2010-05-06

... Fuel Storage Casks: NUHOMS[supreg] HD System Revision 1 AGENCY: Nuclear Regulatory Commission. ACTION... storage regulations by revising the Transnuclear, Inc. (TN) NUHOMS[supreg] HD System listing within the... System cask design within the list of approved spent fuel storage casks that power reactor licensees can...

SEARCHING FOR TROJAN ASTEROIDS IN THE HD 209458 SYSTEM: SPACE-BASED MOST PHOTOMETRY AND DYNAMICAL MODELING

International Nuclear Information System (INIS)

Moldovan, Reka; Matthews, Jaymie M.; Gladman, Brett; Bottke, William F.; Vokrouhlicky, David

2010-01-01

We have searched Microvariability and Oscillations of Stars (MOST) satellite photometry obtained in 2004, 2005, and 2007 of the solar-type star HD 209458 for Trojan asteroid swarms dynamically coupled with the system's transiting 'hot Jupiter' HD 209458b. Observations of the presence and nature of asteroids around other stars would provide unique constraints on migration models of exoplanetary systems. Our results set an upper limit on the optical depth of Trojans in the HD 209458 system that can be used to guide current and future searches of similar systems by upcoming missions. Using cross-correlation methods with artificial signals implanted in the data, we find that our detection limit corresponds to a relative Trojan transit depth of 1 x10 -4 , equivalent to ∼1 lunar mass of asteroids, assuming power-law Trojan size distributions similar to Jupiter's Trojans in our solar system. We confirm with dynamical interpretations that some asteroids could have migrated inward with the planet to its current orbit at 0.045 AU, and that the Yarkovsky effect is ineffective at eliminating objects of >1 m in size. However, using numerical models of collisional evolution we find that, due to high relative speeds in this confined Trojan environment, collisions destroy the vast majority of the asteroids in -7 .

Assembly and Test of HD2, a 36 mm bore high field Nb3Sn Dipole Magnet

International Nuclear Information System (INIS)

Ferracin, P.; Bingham, B.; Caspi, S.; Cheng, D.W.; Dietderich, D.R.; Felice, H.; Godeke, A.; Hafalia, A.R.; Hannaford, C.R.; Joseph, J.; Lietzke, A.F.; Lizarazo, J.; Sabbi, G.; Trillaud, F.; Wang, X.

2008-01-01

We report on the fabrication, assembly, and test of the Nb 3 Sn dipole magnet HD2. The magnet, aimed at demonstrating the application of Nb 3 Sn superconductor in high field accelerator-type dipoles, features a 36 mm clear bore surrounded by block-type coils with tilted ends. The coil design is optimized to minimize geometric harmonics in the aperture and the magnetic peak field on the conductor in the coil ends. The target bore field of 15 T at 4.3 K is consistent with critical current measurements of extracted strands. The coils are horizontally pre-stressed during assembly using an external aluminum shell pre-tensioned with water-pressurized bladders. Axial pre-loading of the coil ends is accomplished through two end plates and four aluminum tension rods. The strain in coil, shell, and rods is monitored with strain gauges during assembly, cool-down and magnet excitation, and compared with 3D finite element computations. Magnet's training performance, quench locations, and ramp-rate dependence are then analyzed and discussed.

A Preliminary Multiple Case Report of Neurocognitive Training for Children With AD/HD in China

Directory of Open Access Journals (Sweden)

Han Jiang

2015-06-01

Full Text Available This preliminary multiple case study examined the behavioral outcomes of neurocognitive training on children with attention-deficit/hyperactivity disorder (AD/HD in China, as well as parent acceptance of the treatment. The training approach targeted working memory, impulse control, and attention/relaxation (via brain electrical activity. Outcome measures included overt behavior as rated by parents and teachers, AD/HD symptom frequency, and parent opinion/feedback. Training was completed by five individuals and delivered via a themed computer game with electroencephalogram (EEG input via a wireless, single-channel, dry-sensor, portable measurement device. The objective (i.e., training outcomes and EEG and subjective (i.e., parent ratings/feedback and teacher ratings data suggested that use of the neurocognitive training resulted in reduced AD/HD behaviors and improvement in socially meaningful outcomes. The parents expressed satisfaction with the training procedure and outcomes. It is concluded that the innovative neurocognitive training approach is effective for improving behavior and reducing symptoms of AD/HD for children in China.

The far-UV spectrum of the low-excitation planetary nebula HD 138403

OpenAIRE

Surdej, Jean; Heck, A.

1982-01-01

Two high-resolution far-UV spectra of the low-excitation planetary nebula HD 138403 are analyzed which were obtained with the IUE satellite over the wavelength range from 1170 to 2070 A. It is shown that the nebula's far-UV spectrum comprises a stellar continuum on which are superimposed a few emission lines, numerous interstellar absorption lines, and various types of P Cygni profiles. Evidence is examined for substantial mass loss from the central nucleus, with terminal velocities of the or...

Search for Black-Holes: the nature of the Unseen Companions of the Systems HD 152667 and 72754

International Nuclear Information System (INIS)

Freitas Pacheco, J.A. de

1978-01-01

The nature of the unseen companions in the single spectroscopic binary systems HD 152667 and HD 72754 is analysed. In the first system, the secondary is likely to be a normal B4 main sequence star while in HD 72754, the secondary, in spite of being the more massive star, is not detected. We cannot at the present, disregard the possibility that this massive object be associated with a collapsed star - a black-hole [pt

GLOBAL INTEGRATED ISR: A BETTER ORGANIZATIONAL CONSTRUCT FOR AIR FORCE LD/HD ISR

Science.gov (United States)

2017-04-06

E-8 intelligence, surveillance, and reconnaissance (ISR) aircraft it refers to as Low Density/High Demand (LD/HD). Current worldwide demand for LD...would allow for the easy flow of missions across CCMD boundaries within, or even inside, the normal book process timeline without having to approach...Quarter 2007). Harvard , James W. "Airmen and Mission Command." Air and Space Power Journal, March - April 2013: 131-146. Headquarters Air Force, Air

Asymmetric H-D exchange reactions of fluorinated aromatic ketones

KAUST Repository

Zhao, Yujun

2012-01-01

Chiral bicyclic guanidine catalyzes the asymmetric H-D exchange reactions. Up to 30% ee was achieved. DFT calculations were employed to elucidate and explain the origin of the reaction\\'s stereoselectivity. © 2012 The Royal Society of Chemistry.

Novel theory of the HD dipole moment. II. Computations

International Nuclear Information System (INIS)

Thorson, W.R.; Choi, J.H.; Knudson, S.K.

1985-01-01

In the preceding paper we derived a new theory of the dipole moments of homopolar but isotopically asymmetric molecules (such as HD, HT, and DT) in which the electrical asymmetry appears directly in the electronic Hamiltonian (in an appropriate Born-Oppenheimer separation) and the dipole moment may be computed as a purely electronic property. In the present paper we describe variation-perturbation calculations and convergence studies on the dipole moment for HD, which is found to have the value 8.51 x 10 -4 debye at 1.40 a.u. Using the two alternative formulations of the electronic problem, we can provide a test of basis-set adequacy and convergence of the results, and such convergence studies are reported here. We have also computed vibration-rotation transition matrix elements and these are compared with experimental and other theoretical results

75 FR 25120 - List of Approved Spent Fuel Storage Casks: NUHOMS® HD System Revision 1

Science.gov (United States)

2010-05-07

...] RIN 3150-AI75 List of Approved Spent Fuel Storage Casks: NUHOMS[supreg] HD System Revision 1 AGENCY...), NUHOMS[supreg] HD System listing within the ``List of Approved Spent Fuel Storage Casks'' to include... Modular Storage System for Irradiated Nuclear Fuel. Docket Number: 72-1030. Certificate Expiration Date...

Secondary electron emission from solid HD and a solid H2-D2 mixture

DEFF Research Database (Denmark)

Sørensen, H.; Børgesen, P.; Hao-Ming, Chen

1983-01-01

Secondary electron emission from solid HD and a solid 0.6 H2 + 0.4 D2 mixture has been studied for electron and hydrogen ion bombardment at primary energies from 0.5 to 3 keV and 2 to 10 keV/amu, respectively. The yield for solid HD is well explained by a simple stoichiometric model of the low...

Highly pathogenic avian influenza virus H5N1 controls type I IFN induction in chicken macrophage HD-11 cells: a polygenic trait that involves NS1 and the polymerase complex

Science.gov (United States)

2012-01-01

Background Influenza A viruses are well characterized to antagonize type I IFN induction in infected mammalian cells. However, limited information is available for avian cells. It was hypothesised that avian influenza viruses (AIV) with distinct virulence may interact differently with the avian innate immune system. Therefore, the type I IFN responses induced by highly virulent and low virulent H5N1 AIV and reassortants thereof were analysed in chicken cells. Results The highly pathogenic (HP) AIV A/chicken/Yamaguchi/7/04 (H5N1) (Yama) did not induce type I IFN in infected chicken HD-11 macrophage-like cells. This contrasted with an NS1 mutant Yama virus (Yama-NS1A144V) and with the attenuated H5N1 AIV A/duck/Hokkaido/Vac-1/04 (Vac) carrying the haemagglutinin (HA) of the Yama virus (Vac-Yama/HA), that both induced type I IFN in these cells. The substitution of the NS segment from Yama with that from Vac in the Yama backbone resulted in induction of type I IFN secretion in HD-11 cells. However, vice versa, the Yama NS segment did not prevent type I IFN induction by the Vac-Yama/HA virus. This was different with the PB1/PB2/PA segment reassortant Yama and Vac-Yama/HA viruses. Whereas the Yama virus with the Vac PB1/PB2/PA segments induced type I IFN in HD-11 cells, the Vac-Yama/HA virus with the Yama PB1/PB2/PA segments did not. As reported for mammalian cells, the expression of H5N1 PB2 inhibited the activation of the IFN-β promoter in chicken DF-1 fibroblast cells. Importantly, the Yama PB2 was more potent at inhibiting the IFN-β promoter than the Vac PB2. Conclusions The present study demonstrates that the NS1 protein and the polymerase complex of the HPAIV Yama act in concert to antagonize chicken type I IFN secretion in HD-11 cells. PB2 alone can also exert a partial inhibitory effect on type I IFN induction. In conclusion, the control of type I IFN induction by H5N1 HPAIV represents a complex phenotype that involves a particular viral gene constellation

High-definition television evaluation for remote handling task performance

International Nuclear Information System (INIS)

Fujita, Y.; Omori, E.; Hayashi, S.; Draper, J.V.; Herndon, J.N.

1986-01-01

This paper describes experiments designed to evaluate the impact of HDTV on the performance of typical remote tasks. The experiments described in this paper compared the performance of four operators using HDTV with their performance while using other television systems. The experiments included four television systems: (1) high-definition color television, (2) high-definition monochromatic television, (3) standard-resolution monochromatic television, and (4) standard-resolution stereoscopic monochromatic television. The stereo system accomplished stereoscopy by displaying two cross-polarized images, one reflected by a half-silvered mirror and one seen through the mirror. Observers wore a pair of glasses with cross-polarized lenses so that the left eye received only the view from the left camera and the right eye received only the view from the right camera

Vibration-free stirling cryocooler for high definition microscopy

Science.gov (United States)

Riabzev, S. V.; Veprik, A. M.; Vilenchik, H. S.; Pundak, N.; Castiel, E.

2009-12-01

The normal operation of high definition Scanning Electronic and Helium Ion microscope tools often relies on maintaining particular components at cryogenic temperatures. This has traditionally been accomplished by using liquid coolants such as liquid Nitrogen. This inherently limits the useful temperature range to above 77 K, produces various operational hazards and typically involves elevated ownership costs, inconvenient logistics and maintenance. Mechanical coolers, over-performing the above traditional method and capable of delivering required (even below 77 K) cooling to the above cooled components, have been well-known elsewhere for many years, but their typical drawbacks, such as high purchasing cost, cooler size, low reliability and high power consumption have so far prevented their wide-spreading. Additional critical drawback is inevitable degradation of imagery performance originated from the wideband vibration export as typical for the operation of the mechanical cooler incorporating numerous movable components. Recent advances in the development of reliable, compact, reasonably priced and dynamically quiet linear cryogenic coolers gave rise to so-called "dry cooling" technologies aimed at eventually replacing the traditional use of outdated liquid Nitrogen cooling facilities. Although much improved these newer cryogenic coolers still produce relatively high vibration export which makes them incompatible with modern high definition microscopy tools. This has motivated further research activity towards developing a vibration free closed-cycle mechanical cryocooler. The authors have successfully adapted the standard low vibration Stirling cryogenic refrigerator (Ricor model K535-LV) delivering 5 W@40 K heat lift for use in vibration-sensitive high definition microscopy. This has been achieved by using passive mechanical counterbalancing of the main portion of the low frequency vibration export in combination with an active feed-forward multi

The Deuterator: software for the determination of backbone amide deuterium levels from H/D exchange MS data

Directory of Open Access Journals (Sweden)

Tsinoremas NF

2007-05-01

Full Text Available Abstract Background The combination of mass spectrometry and solution phase amide hydrogen/deuterium exchange (H/D exchange experiments is an effective method for characterizing protein dynamics, and protein-protein or protein-ligand interactions. Despite methodological advancements and improvements in instrumentation and automation, data analysis and display remains a tedious process. The factors that contribute to this bottleneck are the large number of data points produced in a typical experiment, each requiring manual curation and validation, and then calculation of the level of backbone amide exchange. Tools have become available that address some of these issues, but lack sufficient integration, functionality, and accessibility required to address the needs of the H/D exchange community. To date there is no software for the analysis of H/D exchange data that comprehensively addresses these issues. Results We have developed an integrated software system for the automated analysis and representation of H/D exchange data that has been titled "The Deuterator". Novel approaches have been implemented that enable high throughput analysis, automated determination of deuterium incorporation, and deconvolution of overlapping peptides. This has been achieved by using methods involving iterative theoretical envelope fitting, and consideration of peak data within expected m/z ranges. Existing common file formats have been leveraged to allow compatibility with the output from the myriad of MS instrument platforms and peptide sequence database search engines. A web-based interface is used to integrate the components of The Deuterator that are able to analyze and present mass spectral data from instruments with varying resolving powers. The results, if necessary, can then be confirmed, adjusted, re-calculated and saved. Additional tools synchronize the curated calculation parameters with replicate time points, increasing throughput. Saved results can then

Spectral calibration of EBT3 and HD-V2 radiochromic film response at high dose using 20 MeV proton beams

Science.gov (United States)

Feng, Yiwei; Tiedje, Henry F.; Gagnon, Katherine; Fedosejevs, Robert

2018-04-01

Radiochromic film is used extensively in many medical, industrial, and scientific applications. In particular, the film is used in analysis of proton generation and in high intensity laser-plasma experiments where very high dose levels can be obtained. The present study reports calibration of the dose response of Gafchromic EBT3 and HD-V2 radiochromic films up to high exposure densities. A 2D scanning confocal densitometer system is employed to carry out accurate optical density measurements up to optical density 5 on the exposed films at the peak spectral absorption wavelengths. Various wavelengths from 400 to 740 nm are also scanned to extend the practical dose range of such films by measuring the response at wavelengths removed from the peak response wavelengths. Calibration curves for the optical density versus exposure dose are determined and can be used for quantitative evaluation of measured doses based on the measured optical densities. It was found that blue and UV wavelengths allowed the largest dynamic range though at some trade-off with overall accuracy.

EVIDENCE FOR THE DIRECT DETECTION OF THE THERMAL SPECTRUM OF THE NON-TRANSITING HOT GAS GIANT HD 88133 b

KAUST Repository

Piskorz, Danielle; Benneke, Bjö rn; Crockett, Nathan R.; Lockwood, Alexandra C.; Blake, Geoffrey A.; Barman, Travis S.; Bender, Chad F.; Bryan, Marta L.; Carr, John S.; Fischer, Debra A.; Howard, Andrew W.; Isaacson, Howard; Johnson, John A.

2016-01-01

We target the thermal emission spectrum of the non-transiting gas giant HD 88133 b with high-resolution near-infrared spectroscopy, by treating the planet and its host star as a spectroscopic binary. For sufficiently deep summed flux observations

MagAO IMAGING OF LONG-PERIOD OBJECTS (MILO). II. A PUZZLING WHITE DWARF AROUND THE SUN-LIKE STAR HD 11112

International Nuclear Information System (INIS)

Rodigas, Timothy J.; Arriagada, Pamela; Faherty, Jacqueline K.; Weinberger, Alycia; Butler, R. Paul; Bergeron, P.; Simon, Amélie; Anglada-Escudé, Guillem; Mamajek, Eric E.; Males, Jared R.; Morzinski, Katie; Close, Laird M.; Hinz, Philip M.; Bailey, Jeremy; Tinney, C. G.; Wittenmyer, Rob; Carter, Brad; Jenkins, James S.; Jones, Hugh; O’Toole, Simon

2016-01-01

HD 11112 is an old, Sun-like star that has a long-term radial velocity (RV) trend indicative of a massive companion on a wide orbit. Here we present direct images of the source responsible for the trend using the Magellan Adaptive Optics system. We detect the object (HD 11112B) at a separation of 2.″2 (100 au) at multiple wavelengths spanning 0.6–4 μ m and show that it is most likely a gravitationally bound cool white dwarf. Modeling its spectral energy distribution suggests that its mass is 0.9–1.1 M ⊙ , which corresponds to very high eccentricity, near edge-on orbits from a Markov chain Monte Carlo analysis of the RV and imaging data together. The total age of the white dwarf is >2 σ , which is discrepant with that of the primary star under most assumptions. The problem can be resolved if the white dwarf progenitor was initially a double white dwarf binary that then merged into the observed high-mass white dwarf. HD 11112B is a unique and intriguing benchmark object that can be used to calibrate atmospheric and evolutionary models of cool white dwarfs and should thus continue to be monitored by RV and direct imaging over the coming years.

MagAO IMAGING OF LONG-PERIOD OBJECTS (MILO). II. A PUZZLING WHITE DWARF AROUND THE SUN-LIKE STAR HD 11112

Energy Technology Data Exchange (ETDEWEB)

Rodigas, Timothy J.; Arriagada, Pamela; Faherty, Jacqueline K.; Weinberger, Alycia; Butler, R. Paul [Department of Terrestrial Magnetism, Carnegie Institution of Washington, 5241 Broad Branch Road, NW, Washington, DC 20015 (United States); Bergeron, P.; Simon, Amélie [Département de Physique, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Québec H3C 3J7 (Canada); Anglada-Escudé, Guillem [School of Physics and Astronomy, Queen Mary, University of London, 327 Mile End Road, London (United Kingdom); Mamajek, Eric E. [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627-0171 (United States); Males, Jared R.; Morzinski, Katie; Close, Laird M.; Hinz, Philip M. [Steward Observatory, The University of Arizona, 933 N. Cherry Avenue, Tucson, AZ 85721 (United States); Bailey, Jeremy; Tinney, C. G.; Wittenmyer, Rob [Exoplanetary Science at UNSW, School of Physics, UNSW Australia, Sydney, NSW 2052 (Australia); Carter, Brad [Computational Engineering and Science Research Centre, University of Southern Queensland, Springfield, QLD 4300 (Australia); Jenkins, James S. [Departamento de Astronomia, Universidad de Chile, Casilla 36-D, Las Condes, Santiago (Chile); Jones, Hugh [Centre for Astrophysics Research, University of Hertfordshire, College Lane, Hatfield, Herts AL10 9AB (United Kingdom); O’Toole, Simon, E-mail: trodigas@carnegiescience.edu [Australian Astronomical Observatory, P.O. Box 915, North Ryde, NSW 1670 (Australia); and others

2016-11-10

HD 11112 is an old, Sun-like star that has a long-term radial velocity (RV) trend indicative of a massive companion on a wide orbit. Here we present direct images of the source responsible for the trend using the Magellan Adaptive Optics system. We detect the object (HD 11112B) at a separation of 2.″2 (100 au) at multiple wavelengths spanning 0.6–4 μ m and show that it is most likely a gravitationally bound cool white dwarf. Modeling its spectral energy distribution suggests that its mass is 0.9–1.1 M {sub ⊙}, which corresponds to very high eccentricity, near edge-on orbits from a Markov chain Monte Carlo analysis of the RV and imaging data together. The total age of the white dwarf is >2 σ , which is discrepant with that of the primary star under most assumptions. The problem can be resolved if the white dwarf progenitor was initially a double white dwarf binary that then merged into the observed high-mass white dwarf. HD 11112B is a unique and intriguing benchmark object that can be used to calibrate atmospheric and evolutionary models of cool white dwarfs and should thus continue to be monitored by RV and direct imaging over the coming years.

Low-frequency high-definition power Doppler in visualizing and defining fetal pulmonary venous connections.

Science.gov (United States)

Liu, Lin; He, Yihua; Li, Zhian; Gu, Xiaoyan; Zhang, Ye; Zhang, Lianzhong

2014-07-01

The use of low-frequency high-definition power Doppler in assessing and defining pulmonary venous connections was investigated. Study A included 260 fetuses at gestational ages ranging from 18 to 36 weeks. Pulmonary veins were assessed by performing two-dimensional B-mode imaging, color Doppler flow imaging (CDFI), and low-frequency high-definition power Doppler. A score of 1 was assigned if one pulmonary vein was visualized, 2 if two pulmonary veins were visualized, 3 if three pulmonary veins were visualized, and 4 if four pulmonary veins were visualized. The detection rate between Exam-1 and Exam-2 (intra-observer variability) and between Exam-1 and Exam-3 (inter-observer variability) was compared. In study B, five cases with abnormal pulmonary venous connection were diagnosed and compared to their anatomical examination. In study A, there was a significant difference between CDFI and low-frequency high-definition power Doppler for the four pulmonary veins observed (P low-frequency high-definition power Doppler was higher than that when employing two-dimensional B-mode imaging or CDFI. There was no significant difference between the intra- and inter-observer variabilities using low-frequency high-definition power Doppler display of pulmonary veins (P > 0.05). The coefficient correlation between Exam-1 and Exam-2 was 0.844, and the coefficient correlation between Exam-1 and Exam-3 was 0.821. In study B, one case of total anomalous pulmonary venous return and four cases of partial anomalous pulmonary venous return were diagnosed by low-frequency high-definition power Doppler and confirmed by autopsy. The assessment of pulmonary venous connections by low-frequency high-definition power Doppler is advantageous. Pulmonary venous anatomy can and should be monitored during fetal heart examination.

Chromospherically active stars. IV - HD 178450 = V478 Lyr: An early-type BY Draconis type binary

Science.gov (United States)

Fekel, Francis C.

1988-01-01

It is shown that the variable star HD 178450 = V478 Lyr is a chromospherically active G8 V single-lined spectroscopic binary with a period of 2.130514 days. This star is characterized by strong UV emission features and a filled-in H-alpha absorption line which is variable in strength. Classified as an early-type BY Draconis system, it is similar to the BY Dra star HD 175742 = V775 Her. The unseen secondary of HD 178450 has a mass of about 0.3 solar masses and is believed to be an M2-M3 dwarf.

Dynamic behavior of PE-HD pipes grade

Czech Academy of Sciences Publication Activity Database

Trnka, Jan; Buchar, Jaroslav; Nezbedová, E.

2017-01-01

Roč. 373, č. 1 (2017), č. článku 1700038. ISSN 1022-1360 R&D Projects: GA MŠk(CZ) EF15_003/0000493 Institutional support: RVO:61388998 Keywords : dynamic behavior * PE-HD * split Hopkinson pressure bar test * strain rate Subject RIV: JI - Composite Materials OBOR OECD: Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics http://onlinelibrary.wiley.com/doi/10.1002/masy.201700038/full

Understanding evaporation characteristics of a drop of distilled sulfur mustard (HD) chemical agent from stainless steel and aluminum substrates

Energy Technology Data Exchange (ETDEWEB)

Jung, H., E-mail: junghs@add.re.kr; Lee, H.W.

2014-05-01

Highlights: • Evaporation rates of HD are obtained from stainless steel and aluminum substrates. • The rates increase with temperature and are linearly proportional to drop size. • HD evaporation from stainless steel follows only constant contact area mechanism. • HD evaporation from aluminum proceeds by a combined mechanism. - Abstract: We report herein the evaporation rates and mechanism of a drop of distilled sulfur mustard (HD) agent from stainless steel and aluminum substrates. For systematic analysis, we used a laboratory-sized wind tunnel, thermal desorption (TD) connected to gas chromatograph/mass spectrometry (GC/MS) and drop shape analysis (DSA). We found that the evaporation rates of HD from stainless steel and aluminum increased with temperature. The rates were also linearly proportional to drop size. The time-dependent contact angle measurement showed that the evaporation of the drop of HD proceeded only by constant contact area mechanism from stainless steel surface. On the other hand, the evaporation of HD from aluminum proceeded by a combined mechanism of constant contact area mode and constant contact angle mode. Our experimental data sets and analysis could be used to predict vapor and contact hazard persistence of chemical warfare agents (CWAs) in the air and on exterior surfaces with chemical releases, which assists the military decision influencing personnel safety and decontamination of the site upon a chemical attack event.

Understanding evaporation characteristics of a drop of distilled sulfur mustard (HD) chemical agent from stainless steel and aluminum substrates

International Nuclear Information System (INIS)

Jung, H.; Lee, H.W.

2014-01-01

Highlights: • Evaporation rates of HD are obtained from stainless steel and aluminum substrates. • The rates increase with temperature and are linearly proportional to drop size. • HD evaporation from stainless steel follows only constant contact area mechanism. • HD evaporation from aluminum proceeds by a combined mechanism. - Abstract: We report herein the evaporation rates and mechanism of a drop of distilled sulfur mustard (HD) agent from stainless steel and aluminum substrates. For systematic analysis, we used a laboratory-sized wind tunnel, thermal desorption (TD) connected to gas chromatograph/mass spectrometry (GC/MS) and drop shape analysis (DSA). We found that the evaporation rates of HD from stainless steel and aluminum increased with temperature. The rates were also linearly proportional to drop size. The time-dependent contact angle measurement showed that the evaporation of the drop of HD proceeded only by constant contact area mechanism from stainless steel surface. On the other hand, the evaporation of HD from aluminum proceeded by a combined mechanism of constant contact area mode and constant contact angle mode. Our experimental data sets and analysis could be used to predict vapor and contact hazard persistence of chemical warfare agents (CWAs) in the air and on exterior surfaces with chemical releases, which assists the military decision influencing personnel safety and decontamination of the site upon a chemical attack event

High-Flux Hemodialysis and High-Volume Hemodiafiltration Improve Serum Calcification Propensity.

Directory of Open Access Journals (Sweden)

Marijke Dekker

Full Text Available Calciprotein particles (CPPs may play an important role in the calcification process. The calcification propensity of serum (T50 is highly predictive of all-cause mortality in chronic kidney disease patients. Whether T50 is therapeutically improvable, by high-flux hemodialysis (HD or hemodiafiltration (HDF, has not been studied yet.We designed a cross-sectional single center study, and included stable prevalent in-center dialysis patients on HD or HDF. Patients were divided into two groups based on dialysis modality, were on a thrice-weekly schedule, had a dialysis vintage of > 3 months and vascular access providing a blood flow rate > 300 ml/min. Calcification propensity of serum was measured by the time of transformation from primary to secondary CPP (T50 test, by time-resolved nephelometry.We included 64 patients, mean convective volume was 21.7L (SD 3.3L. In the pooled analysis, T50 levels increased in both the HD and HDF group with pre- and post-dialysis (mean (SD of 244(64 - 301(57 and 253(55 - 304(61 min respectively (P = 0.43(HD vs. HDF. The mean increase in T50 was 26.29% for HD and 21.97% for HDF patients (P = 0.61 (HD vs. HDF. The delta values (Δ of calcium, phosphate and serum albumin were equal in both groups. Baseline T50 was negatively correlated with phosphate, and positively correlated with serum magnesium and fetuin-A. The ΔT50 was mostly influenced by Δ phosphate (r = -0.342; P = 0.002 HD and r = -0.396; P<0.001 HDF in both groups.HD and HDF patients present with same baseline T50 calcification propensity values pre-dialysis. Calcification propensity is significantly improved during both HD and HDF sessions without significant differences between both modalities.

Astrometry, radial velocity, and photometry: the HD 128311 system remixed with data from HST, HET, and APT

International Nuclear Information System (INIS)

McArthur, Barbara E.; Benedict, G. Fritz.; Cochran, William D.; Henry, Gregory W.; Hatzes, Artie; Harrison, Tom E.; Johns-Krull, Chris; Nelan, Ed

2014-01-01

We have used high-cadence radial velocity measurements from the Hobby-Eberly Telescope with published velocities from the Lick 3 m Shane Telescope, combined with astrometric data from the Hubble Space Telescope (HST) Fine Guidance Sensors to refine the orbital parameters of the HD 128311 system, and determine an inclination of 55.°95 ± 14.°55 and true mass of 3.789 −0.432 +0.924 M JUP for HD 128311 c. The combined radial velocity data also reveal a short period signal which could indicate a third planet in the system with an Msin i of 0.133 ± 0.005 M JUP or stellar phenomena. Photometry from the T12 0.8 m automatic photometric telescope at the Fairborn Observatory and HST are used to determine a photometric period close to, but not within the errors of the radial velocity signal. We performed a cross-correlation bisector analysis of the radial velocity data to look for correlations with the photometric period and found none. Dynamical integrations of the proposed system show long-term stability with the new orbital parameters of over 10 million years. Our new orbital elements do not support the claims of HD 128311 b and c being in mean motion resonance.

Strong water absorption in the dayside emission spectrum of the planet HD 189733b.

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Grillmair, Carl J; Burrows, Adam; Charbonneau, David; Armus, Lee; Stauffer, John; Meadows, Victoria; van Cleve, Jeffrey; von Braun, Kaspar; Levine, Deborah

2008-12-11

Recent observations of the extrasolar planet HD 189733b did not reveal the presence of water in the emission spectrum of the planet. Yet models of such 'hot-Jupiter' planets predict an abundance of atmospheric water vapour. Validating and constraining these models is crucial to understanding the physics and chemistry of planetary atmospheres in extreme environments. Indications of the presence of water in the atmosphere of HD 189733b have recently been found in transmission spectra, where the planet's atmosphere selectively absorbs the light of the parent star, and in broadband photometry. Here we report the detection of strong water absorption in a high-signal-to-noise, mid-infrared emission spectrum of the planet itself. We find both a strong downturn in the flux ratio below 10 microm and discrete spectral features that are characteristic of strong absorption by water vapour. The differences between these and previous observations are significant and admit the possibility that predicted planetary-scale dynamical weather structures may alter the emission spectrum over time. Models that match the observed spectrum and the broadband photometry suggest that heat redistribution from the dayside to the nightside is weak. Reconciling this with the high nightside temperature will require a better understanding of atmospheric circulation or possible additional energy sources.

Business Travel | Climate Neutral Research Campuses | NREL

Science.gov (United States)

, for example, business air travel generated 27,000 tons of carbon dioxide in 2008, accounting for 8.5 immersion into high-definition telepresence meetings (see example project below). In addition to in summer 2009. The facility consists of four high-definition liquid crystal displays (HD-LCD

State resolved rotational excitation in HD+D2 collisions. II. Angular dependence of 0→2 transitions

International Nuclear Information System (INIS)

Buck, U.; Huisken, F.; Maneke, G.; Schaefer, J.

1983-01-01

Time-of-flight spectra for the scattering of HD molecules from D 2 molecules have been measured at a collision energy of E = 70.3 meV over a range of center-of-mass scattering angles from 45 0 to 158 0 . The spectra reveal clearly resolved transitions at the energy loss ΔE = 33 meV which corresponds to 0→2 transitions of HD and the double transition 0→1 of HD and 0→2 of D 2 . The differential cross sections derived from these spectra increase with increasing scattering angle from 1.7% to 34.7% of the elastic cross section. The pure 0→2 transition of D 2 which only needs 22 meV to be induced could not be detected within our experimental sensitivity of 0.02 A 2 /sr. Closed coupled calculations based on the ab initio potential surface of Meyer and Schaefer show that this result can be explained by the different coupling terms which are responsible for these transitions. In contrast to the 0→1 transition the 0→2 transition of HD proved to be sensitive to the anisotropic part of the interaction potential for the homonuclear system. The comparison of experimental and calculated cross sections for the ab initio potential of Meyer and Schaefer reveals discrepancies for the 0→1 transition of HD, but shows agreement for the 0→2 transition of HD at intermediate angles

Resonant ion-pair formation in electron collisions with HD+ and OH+

International Nuclear Information System (INIS)

Larson, Aa.; Djuric, N.; Zong, W.; Greene, C. H.; Orel, A. E.; Al-Khalili, A.; Derkatch, A. M.; Le Padellec, A.; Neau, A.; Rosen, S.

2000-01-01

Resonant ion-pair formation from collisions of electrons with electronic and vibronic ground-state diatomic molecular ions has been studied in the present work for HD + and OH + . The cross section for HD + has a magnitude of the order of 3x10 -19 cm 2 and is characterized by an energy threshold and 14 resolved peaks in the energy range up to 16 eV. A theoretical study confirms that the structures derive primarily from quantum interference of the multiple dissociation pathways. Measurements for OH + reveal that the cross section for H + and O - formation is lower than 10 -21 cm 2 at energies of 6 and 12 eV. (c) 2000 The American Physical Society

Some measurements of H/D polarizability isotope effects using differential refractometry

Energy Technology Data Exchange (ETDEWEB)

Foster Smith, M; Van Hook, W A [Tennessee Univ., Knoxville (USA). Dept. of Chemistry

1989-05-01

Refractive index differences between the H and D isomers of some common molecules in the liquid phase were measured between 404.7 and 690.0 nm. The data are combined with information on molar volume isotope effects to yield values for H/D isotope effects on the static polarizability, the vibrational contribution to the static and frequency dependent parts of the polarizability, and the H/D isotope effect on the second moment of the electronic charge distribution. The present results suffice to demonstrate the practicability of this technique to measure the components of the polarizability listed above. However for accurate resolution of the vibrational and second moment contributions, refractive index data of still greater precision will be required. (orig.).

Some measurements of H/D polarizability isotope effects using differential refractometry

International Nuclear Information System (INIS)

Foster Smith, M.; Van Hook, W.A.

1989-01-01

Refractive index differences between the H and D isomers of some common molecules in the liquid phase were measured between 404.7 and 690.0 nm. The data are combined with information on molar volume isotope effects to yield values for H/D isotope effects on the static polarizability, the vibrational contribution to the static and frequency dependent parts of the polarizability, and the H/D isotope effect on the second moment of the electronic charge distribution. The present results suffice to demonstrate the practicability of this technique to measure the components of the polarizability listed above. However for accurate resolution of the vibrational and second moment contributions, refractive index data of still greater precision will be required. (orig.)

CHANDRA AND SUZAKU OBSERVATIONS OF THE Be/X-RAY STAR HD110432

International Nuclear Information System (INIS)

Torrejón, J. M.; Schulz, N. S.; Nowak, M. A.

2012-01-01

We present an analysis of a pointed 141 ks Chandra high-resolution transmission gratings observation of the Be X-ray emitting star HD110432, a prominent member of the γ Cas analogs. This observation represents the first high-resolution spectrum taken for this source as well as the longest uninterrupted observation of any γ Cas analog. The Chandra light curve shows a high variability but its analysis fails to detect any coherent periodicity up to a frequency of 0.05 Hz. Hardness ratio versus intensity analyses demonstrate that the relative contributions of the [1.5-3] Å, [3-6] Å, and [6-16] Å energy bands to the total flux change rapidly in the short term. The analysis of the Chandra High Energy Transmission Grating (HETG) spectrum shows that, to correctly describe the spectrum, three model components are needed. Two of those components are optically thin thermal plasmas of different temperatures (kT ≈ 8-9 and 0.2-0.3 keV, respectively) described by the models vmekal or bvapec. The Fe abundance in each of these two components appears equal within the errors and is slightly subsolar with Z ≈ 0.75 Z ☉ . The bvapec model better describes the Fe L transitions, although it cannot fit well the Na XI Lyα line at 10.02 Å, which appears to be overabundant. Two different models seem to describe well the third component. One possibility is a third hot optically thin thermal plasma at kT = 16-21 keV with an Fe abundance Z ≈ 0.3 Z ☉ , definitely smaller than for the other two thermal components. Furthermore, the bvapec model describes well the Fe K shell transitions because it accounts for the turbulence broadening of the Fe XXV and Fe XXVI lines with a v turb ≈ 1200 km s –1 . These two lines, contributed mainly by the hot thermal plasma, are significantly wider than the Fe Kα line whose FWHM ☉ , and a very hot second plasma with kT ≈ 33 keV or, alternatively, a power law with photon index of Γ = 1.58. In either case, each one of the two components

75 FR 27401 - List of Approved Spent Fuel Storage Casks: NUHOMS® HD System Revision 1; Correction

Science.gov (United States)

2010-05-17

... Storage Casks: NUHOMS[reg] HD System Revision 1; Correction AGENCY: Nuclear Regulatory Commission. ACTION... HD spent fuel storage cask system. This action is necessary to correctly specify the effective date... on May 6, 2010 (75 FR 24786), that amends the regulations that govern storage of spent nuclear fuel...

Intra-individual cognitive imbalance in ASD between perceptual reasoning and ambiguity-solving related to tool use: Comparison among children exhibiting ASD, AD/HD, and typical development.

Science.gov (United States)

Wakusawa, Keisuke; Nara, Chieko; Kubota, Yuki; Tomizawa, Yayoi; Taki, Yasuyuki; Sassa, Yuko; Kobayashi, Satoru; Suzuki-Muromoto, Sato; Hirose, Mieko; Yokoyama, Hiroyuki; Nara, Takahiro; Kure, Shigeo; Mori, Norio; Takei, Noriyoshi; Kawashima, Ryuta

2018-01-01

Several studies have suggested that objective deficits in the processing of abstract information in conjunction with an enhanced ability to process concrete information is a definitive characteristic of autism spectrum disorder (ASD). However, this cognitive imbalance is not necessarily clear in high-functioning autistic individuals who do not display absolute differences relative to typically developing (TD) populations. Thus, the purpose of this study was to identify this cognitive tendency in high-functioning autistic individuals using intra-individual cognitive comparisons. The reaction times (RTs) of TD children, children with ASD, and children with attention deficit hyperactivity disorder (AD/HD) (n=17 in each group, mean age=11.9years, age range=9.8-15.8years) were compared using the Which/How-to-Apply Tools (W/HAT) test, which consists of tasks requiring the adaptive use of novel tools and familiar tools in atypical and typical situations. Differences in RTs between the atypical and typical trials ([A-T]) were used to assess intra-individual cognitive imbalances. As predicted, the [A-T] scores of the ASD group were significantly higher than those of the TD group even though the RTs in the atypical and typical trials did not differ. Additionally, the [A-T] values were significantly higher in the ASD group than in the AD/HD group, which indicates that the cognitive imbalance was specific to ASD individuals. No significant interaction was detected between the trial and subject group. The findings of this study demonstrate that a cognitive imbalance in ASD individuals may enhance the current understanding of the pathophysiology of this disorder, which is found in a range of individuals, including those with obvious cortical dysfunction to those with only intra-individual imbalances. Copyright © 2017 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

IUE observations of an active region of HD206860

Energy Technology Data Exchange (ETDEWEB)

Blanco, C; Catalano, S; Marilli, E [Catania Univ. (Italy). Ist. di Astronomia

1979-08-23

The results of UV observations, with the IUE, of the Mg II H and k lines of HD206860, a GOV star, are reported. The aim of the observations was to search for short-term variability of the chromospheric emission connected with the rotation of the star.

Simulation of polarimetric effects in planetary system HD 189733

Science.gov (United States)

Frantseva, K.; Kostogryz, N. M.; Yakobchuk, T. M.

2012-11-01

In this paper we present results of linear polarization modelling for HD 189733 in the U filter using the Monte Carlo method. Our simulations are based on the well known effect that linear polarization of a centrosymmetric unresolved star becomes non-zero during the planet transit or in the presence of spots on its surface. HD 189733 is currently the brightest (m_{V}=7.67^{m}) known star to harbour a transiting exoplanet. This fact, along with the short orbital period (2.2 d), makes it very suitable for different types of observations including polarimetry. Since we are interested in occultation effects, a very important parameter is the ratio of the planet to star radii, which is also very large (0.15). As the host star is active and spots may cover up to 1% of the planetary surface, we perform our simulations for different spot parameters such as sizes, locations on the stellar disk, and temperatures.

Identifying Motor, Emotional-Behavioral, and Cognitive Deficits that Comprise the Triad of HD Symptoms from Patient, Caregiver, and Provider Perspectives

Directory of Open Access Journals (Sweden)

David Victorson

2014-04-01

Full Text Available Background: The objective of this study was to identify important attributes associated with the triad of symptoms (cognition, emotional–behavioral, and motor of Huntington's disease (HD from patient, caregiver, and medical provider perspectives to facilitate development of a new disease‐specific, health‐related quality of life (HRQOL instrument. Methods: We conducted a targeted literature review of HD and HRQOL instruments, expert surveys, and patient and caregiver phone‐based interviews to extract information on the symptoms and issues most relevant to the HD symptom triad (HD triad. The data collected from these sources were used to generate themes and subdomains and to develop an integrated schema that highlights the key dimensions of the triad. Results: The search identified the following areas: emotional functioning/behavioral changes (e.g., positive emotions, sadness/depression; cognitive functioning (e.g., memory/learning, attention/comprehension; physical functioning (e.g., motor functioning, medication; social functioning (e.g., leisure, interpersonal relationships; end‐of‐life concerns/planning; and gene testing. Fifteen individuals diagnosed with HD and 16 HD caregivers, recruited from several Huntington's Disease Society of America support group networks, completed phone interviews. Nineteen US medical providers who specialize in HD completed the online survey. Twenty‐six subdomains of the HD symptom triad (seven cognition, 12 emotional–behavioral, and seven motor emerged relatively consistently across patient, caregiver, and provider samples. These included movements/chorea, memory impairment, depression, and anxiety. Discussion: Based on an integrated, mixed‐methods approach, important HD triad symptom were identified and organized into a guiding schema. These patient‐, caregiver‐, and provider‐triangulated data served as the basis for development of a HD‐specific HRQOL instrument, the HD‐PRO‐TRIAD™.

Age-Related Vitamin D Deficiency Is Associated with Reduced Macular Ganglion Cell Complex: A Cross-Sectional High-Definition Optical Coherence Tomography Study.

Directory of Open Access Journals (Sweden)

Mathieu Uro

Full Text Available Vitamin D deficiency is associated with smaller volume of optic chiasm in older adults, indicating a possible loss of the visual axons and their cellular bodies. Our objective was to determine whether vitamin D deficiency in older adults is associated with reduced thickness of the ganglion cell complex (GCC and of the retinal nerve fibre layer (RNFL, as measured with high-definition optical coherence tomography (HD-OCT.Eighty-five French older community-dwellers without open-angle glaucoma and patent age-related macular degeneration (mean, 71.1±4.7 years; 45.9% female from the GAIT study were separated into 2 groups according to serum 25OHD level (i.e., deficient≤25 nmol/L or sufficient>25 nmol/L. Measurements of GCC and RNFL thickness were performed using HD-OCT. Age, gender, body mass index, number of comorbidities, dementia, functional autonomy, intracranial volume, visual acuity, serum calcium concentration and season of testing were considered as potential confounders.Mean serum 25OHD concentration was 58.4±26.8 nmol/L. Mean logMAR visual acuity was 0.03±0.06. Mean visual field mean deviation was -1.25±2.29 dB. Patients with vitamin D deficiency (n=11 had a reduced mean GCC thickness compared to those without vitamin D deficiency (72.1±7.4 μm versus 77.5±7.5 μm, P=0.028. There was no difference of the mean RNFL thickness in these two groups (P=0.133. After adjustment for potential confounders, vitamin D deficiency was associated with reduced GCC thickness (ß=-5.12, P=0.048 but not RNFL thickness (ß=-9.98, P=0.061. Specifically, vitamin D deficiency correlated with the superior medial GCC area (P=0.017 and superior temporal GCC area (P=0.010.Vitamin D deficiency in older patients is associated with reduced mean GCC thickness, which can represent an early stage of optic nerve damage, prior to RNFL loss.

75 FR 27463 - List of Approved Spent Fuel Storage Casks: NUHOMS® HD System Revision 1; Correction

Science.gov (United States)

2010-05-17

... Fuel Storage Casks: NUHOMS[supreg] HD System Revision 1; Correction AGENCY: Nuclear Regulatory... fuel storage casks to add revision 1 to the NUHOMS HD spent fuel storage cask system. This action is... Federal Register on May 7, 2010 (75 FR 25120), that proposes to amend the regulations that govern storage...

Long-term safety and efficacy of autologous platelet lysate drops for treatment of ocular GvHD.

Science.gov (United States)

Pezzotta, S; Del Fante, C; Scudeller, L; Rossi, G C; Perotti, C; Bianchi, P E; Antoniazzi, E

2017-01-01

Current ocular GvHD (oGvHD) treatments are suboptimal. We investigated the safety and efficacy of long-term continuous treatment with autologous platelet lysate (PL) drops in patients with oGvHD Dry Eye Syndrome (DES) score 2-3 refractory to topical conventional therapy. Ophthalmic evaluation was performed at 6 month intervals. Symptoms were assessed using the Glaucoma Symptom Scale (GSS). Patients were defined 'responders' when showing a reduction at least one grade on National Institutes of Health Eye Score from baseline at the 6 month visit. Thirty-one patients were included, and 16 (51%) completed 36 months of follow-up (range 6.5-72.7). At 6 months all patients were classified as responders: median GSS symptom score decreased from 70 to 41 (33 at 36 months), median GSS function score reduced from 68 to 46 (33 at 36 months) (all P<0.001). Median Tear Break Up Time improved from 3 to 6 s after 6 months and was maintained over time. All signs improved at 6 and 36 months (clinical and statistical significance). No severe adverse events occurred. Long-term treatment with PL drops is secure and effective for oGvHD and can be an efficient therapy option from initial stages of oGvHD to prevent permanent ocular impairment and improving quality of life.

Spectrum variability of the silicon Ap star HD 192913

International Nuclear Information System (INIS)

Riabchikova, T.A.; Davidova, E.S.; Adelman, S.J.

1990-01-01

The metal lines in the spectrum of the silicon Ap star HD 192913 are found to change with the photometric period. Many commonly found atomic species have lines which vary together in phase. The spectrum contains lines of most of the doubly ionized rare earth elements. 27 refs

Locus-specific microemulsion catalysts for sulfur mustard (HD) chemical warfare agent decontamination.

Science.gov (United States)

Fallis, Ian A; Griffiths, Peter C; Cosgrove, Terence; Dreiss, Cecile A; Govan, Norman; Heenan, Richard K; Holden, Ian; Jenkins, Robert L; Mitchell, Stephen J; Notman, Stuart; Platts, Jamie A; Riches, James; Tatchell, Thomas

2009-07-22

The rates of catalytic oxidative decontamination of the chemical warfare agent (CWA) sulfur mustard (HD, bis(2-chlororethyl) sulfide) and a range (chloroethyl) sulfide simulants of variable lipophilicity have been examined using a hydrogen peroxide-based microemulsion system. SANS (small-angle neutron scattering), SAXS (small-angle X-ray scattering), PGSE-NMR (pulsed-gradient spin-echo NMR), fluorescence quenching, and electrospray mass spectroscopy (ESI-MS) were implemented to examine the distribution of HD, its simulants, and their oxidation/hydrolysis products in a model oil-in-water microemulsion. These measurements not only present a means of interpreting decontamination rates but also a rationale for the design of oxidation catalysts for these toxic materials. Here we show that by localizing manganese-Schiff base catalysts at the oil droplet-water interface or within the droplet core, a range of (chloroethyl) sulfides, including HD, spanning some 7 orders of octanol-water partition coefficient (K(ow)), may be oxidized with equal efficacy using dilute (5 wt. % of aqueous phase) hydrogen peroxide as a noncorrosive, environmentally benign oxidant (e.g., t(1/2) (HD) approximately 18 s, (2-chloroethyl phenyl sulfide, C(6)H(5)SCH(2)CH(2)Cl) approximately 15 s, (thiodiglycol, S(CH(2)CH(2)OH)(2)) approximately 19 s {20 degrees C}). Our observations demonstrate that by programming catalyst lipophilicity to colocalize catalyst and substrate, the inherent compartmentalization of the microemulsion can be exploited to achieve enhanced rates of reaction or to exert control over product selectivity. A combination of SANS, ESI-MS and fluorescence quenching measurements indicate that the enhanced catalytic activity is due to the locus of the catalyst and not a result of partial hydrolysis of the substrate.

Perception, experience, and response to genetic discrimination in Huntington disease: the international RESPOND-HD study.

Science.gov (United States)

Erwin, Cheryl; Williams, Janet K; Juhl, Andrew R; Mengeling, Michelle; Mills, James A; Bombard, Yvonne; Hayden, Michael R; Quaid, Kimberly; Shoulson, Ira; Taylor, Sandra; Paulsen, Jane S

2010-07-01

Genetic discrimination-defined as the denial of rights, privileges, or opportunities or other adverse treatment based solely on genetic information (including family history)-is an important concern to patients, healthcare professionals, lawmakers, and family members at risk for carrying a deleterious gene. Data from the United States, Canada, and Australia were collected from 433 individuals at risk for Huntington disease (HD) who have tested either positive or negative for the gene that causes HD and family members of affected individuals who have a 50% risk for developing the disorder but remain untested. Across all three countries, a total of 46.2% of respondents report genetic discrimination or stigma based on either their family history of HD or genetic testing for the HD gene mutation. We report on the overall incidence of discrimination and stigma in the domains of insurance (25.9%), employment (6.5%), relationships (32.9%), and other transactions (4.6%) in the United States, Canada, and Australia combined. The incidence of self-reported discrimination is less than the overall worry about the risk of discrimination, which is more prevalent in each domain. Despite a relatively low rate of perceived genetic discrimination in the areas of health insurance and employment, compared to the perception of discrimination and stigma in personal relationships, the cumulative burden of genetic discrimination across all domains of experience represents a challenge to those at risk for HD. The effect of this cumulative burden on daily life decisions remains unknown. (c) 2010 Wiley-Liss, Inc.

Epstein-Barr virus (EBV antibody in childhood Hodgkin's disease (HD at Imam khomeini Medical Complex

Directory of Open Access Journals (Sweden)

Nahid M

1998-08-01

Full Text Available Association of EBV with the tumor cells of HD has been proven by a variety of the methods, using serologic and immunohistochemical techniques and in the recent years with molecular biologic techniques which can detect EBV genome in tumor biopsies. In this regard we prompted to perform a case control study on 25 childhood HD cases with respected to their antibodies gainst EBNA and EBV-IgM antibodies in Imam Khomeini Hospital in Tehran. In our study the ratio of positive titers was significantly higher among HD patients compared with age and sex-matched healthy controls.

Enhanced neuronal glucose transporter expression reveals metabolic choice in a HD Drosophila model.

Science.gov (United States)

Besson, Marie Thérèse; Alegría, Karin; Garrido-Gerter, Pamela; Barros, Luis Felipe; Liévens, Jean-Charles

2015-01-01

Huntington's disease is a neurodegenerative disorder caused by toxic insertions of polyglutamine residues in the Huntingtin protein and characterized by progressive deterioration of cognitive and motor functions. Altered brain glucose metabolism has long been suggested and a possible link has been proposed in HD. However, the precise function of glucose transporters was not yet determined. Here, we report the effects of the specifically-neuronal human glucose transporter expression in neurons of a Drosophila model carrying the exon 1 of the human huntingtin gene with 93 glutamine repeats (HQ93). We demonstrated that overexpression of the human glucose transporter in neurons ameliorated significantly the status of HD flies by increasing their lifespan, reducing their locomotor deficits and rescuing eye neurodegeneration. Then, we investigated whether increasing the major pathways of glucose catabolism, glycolysis and pentose-phosphate pathway (PPP) impacts HD. To mimic increased glycolytic flux, we overexpressed phosphofructokinase (PFK) which catalyzes an irreversible step in glycolysis. Overexpression of PFK did not affect HQ93 fly survival, but protected from photoreceptor loss. Overexpression of glucose-6-phosphate dehydrogenase (G6PD), the key enzyme of the PPP, extended significantly the lifespan of HD flies and rescued eye neurodegeneration. Since G6PD is able to synthesize NADPH involved in cell survival by maintenance of the redox state, we showed that tolerance to experimental oxidative stress was enhanced in flies co-expressing HQ93 and G6PD. Additionally overexpressions of hGluT3, G6PD or PFK were able to circumvent mitochondrial deficits induced by specific silencing of genes necessary for mitochondrial homeostasis. Our study confirms the involvement of bioenergetic deficits in HD course; they can be rescued by specific expression of a glucose transporter in neurons. Finally, the PPP and, to a lesser extent, the glycolysis seem to mediate the hGluT3

Enhanced neuronal glucose transporter expression reveals metabolic choice in a HD Drosophila model.

Directory of Open Access Journals (Sweden)

Marie Thérèse Besson

Full Text Available Huntington's disease is a neurodegenerative disorder caused by toxic insertions of polyglutamine residues in the Huntingtin protein and characterized by progressive deterioration of cognitive and motor functions. Altered brain glucose metabolism has long been suggested and a possible link has been proposed in HD. However, the precise function of glucose transporters was not yet determined. Here, we report the effects of the specifically-neuronal human glucose transporter expression in neurons of a Drosophila model carrying the exon 1 of the human huntingtin gene with 93 glutamine repeats (HQ93. We demonstrated that overexpression of the human glucose transporter in neurons ameliorated significantly the status of HD flies by increasing their lifespan, reducing their locomotor deficits and rescuing eye neurodegeneration. Then, we investigated whether increasing the major pathways of glucose catabolism, glycolysis and pentose-phosphate pathway (PPP impacts HD. To mimic increased glycolytic flux, we overexpressed phosphofructokinase (PFK which catalyzes an irreversible step in glycolysis. Overexpression of PFK did not affect HQ93 fly survival, but protected from photoreceptor loss. Overexpression of glucose-6-phosphate dehydrogenase (G6PD, the key enzyme of the PPP, extended significantly the lifespan of HD flies and rescued eye neurodegeneration. Since G6PD is able to synthesize NADPH involved in cell survival by maintenance of the redox state, we showed that tolerance to experimental oxidative stress was enhanced in flies co-expressing HQ93 and G6PD. Additionally overexpressions of hGluT3, G6PD or PFK were able to circumvent mitochondrial deficits induced by specific silencing of genes necessary for mitochondrial homeostasis. Our study confirms the involvement of bioenergetic deficits in HD course; they can be rescued by specific expression of a glucose transporter in neurons. Finally, the PPP and, to a lesser extent, the glycolysis seem to

Competition H(D) kinetic isotope effects in the autoxidation of hydrocarbons.

Science.gov (United States)

Muchalski, Hubert; Levonyak, Alexander J; Xu, Libin; Ingold, Keith U; Porter, Ned A

2015-01-14

Hydrogen atom transfer is central to many important radical chain sequences. We report here a method for determination of both the primary and secondary isotope effects for symmetrical substrates by the use of NMR. Intramolecular competition reactions were carried out on substrates having an increasing number of deuterium atoms at symmetry-related sites. Products that arise from peroxyl radical abstraction at each position of the various substrates reflect the competition rates for H(D) abstraction. The primary KIE for autoxidation of tetralin was determined to be 15.9 ± 1.4, a value that exceeds the maximum predicted by differences in H(D) zero-point energies (∼7) and strongly suggests that H atom abstraction by the peroxyl radical occurs with substantial quantum mechanical tunneling.

Serum Bicarbonate And Survival In Peritoneal Dialysis (Pd: Comparison With Hemodialysis (Hd

Directory of Open Access Journals (Sweden)

Tania Sharma

2012-06-01

Full Text Available Correction of metabolic acidosis is one of the goals of effective dialysis. The KDOQI guidelines recommend serum bicarbonate >22 meq/L irrespective of dialysis modality. Since the measured bicarbonate reflects the steady state in PD patients and the lowest inter-dialytic value in HD patients, we compared the survival predictability of serum bicarbonate 10,400 PD and 110,951 HD patients treated in DaVita facilities from 7/2001-6/2006 with follow-up through 6/2007. PD patients were substantially less likely to have lower serum bicarbonate (adjusted odds, 22 meq/L for all end-stage renal disease irrespective of dialysis modality.fx1

Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.

Science.gov (United States)

Handley, Renee R; Reid, Suzanne J; Brauning, Rudiger; Maclean, Paul; Mears, Emily R; Fourie, Imche; Patassini, Stefano; Cooper, Garth J S; Rudiger, Skye R; McLaughlan, Clive J; Verma, Paul J; Gusella, James F; MacDonald, Marcy E; Waldvogel, Henry J; Bawden, C Simon; Faull, Richard L M; Snell, Russell G

2017-12-26

The neurodegenerative disorder Huntington's disease (HD) is typically characterized by extensive loss of striatal neurons and the midlife onset of debilitating and progressive chorea, dementia, and psychological disturbance. HD is caused by a CAG repeat expansion in the Huntingtin ( HTT ) gene, translating to an elongated glutamine tract in the huntingtin protein. The pathogenic mechanism resulting in cell dysfunction and death beyond the causative mutation is not well defined. To further delineate the early molecular events in HD, we performed RNA-sequencing (RNA-seq) on striatal tissue from a cohort of 5-y-old OVT73 -line sheep expressing a human CAG-expansion HTT cDNA transgene. Our HD OVT73 sheep are a prodromal model and exhibit minimal pathology and no detectable neuronal loss. We identified significantly increased levels of the urea transporter SLC14A1 in the OVT73 striatum, along with other important osmotic regulators. Further investigation revealed elevated levels of the metabolite urea in the OVT73 striatum and cerebellum, consistent with our recently published observation of increased urea in postmortem human brain from HD cases. Extending that finding, we demonstrate that postmortem human brain urea levels are elevated in a larger cohort of HD cases, including those with low-level neuropathology (Vonsattel grade 0/1). This elevation indicates increased protein catabolism, possibly as an alternate energy source given the generalized metabolic defect in HD. Increased urea and ammonia levels due to dysregulation of the urea cycle are known to cause neurologic impairment. Taken together, our findings indicate that aberrant urea metabolism could be the primary biochemical disruption initiating neuropathogenesis in HD.

Results of a Long-Term Spectral and Photometric Monitoring of the Herbig Ae Star HD 179218

Science.gov (United States)

Kozlova, O. V.; Alekseev, I. Yu.

2017-06-01

We present the results of the long-term spectroscopic and photometric monitoring of the Herbig Ae star HD 179218. The high-resolution spectra (R = 20000) were made on the 2.6-m telescope at the Crimean Astrophysical Observatory (CrAO) in the regions of Hα emission line. The photometric observations were obtained on 1.25-m telescope AZT-11 (CrAO) equipped with the UBVRI electrophotometer-polarimeter. Our results showed that Hα emission parameters demonstrate the long- term variability on the time scale about 4000 days. The same variability is observed in the change of the stellar brightness in V-band. The unusual behavior the V-I color index depending on the stellar brightness in the V-band can be concluded that around the star there is an additional source of IR-radiation. We believe that the obtained results can be explained by the presence in the vicinity of HD 179218 a low-mass component.

Affordable headphones for accessible screening audiometry: An evaluation of the Sennheiser HD202 II supra-aural headphone.

Science.gov (United States)

Van der Aerschot, Mathieu; Swanepoel, De Wet; Mahomed-Asmail, Faheema; Myburgh, Herman Carel; Eikelboom, Robert Henry

2016-11-01

Evaluation of the Sennheiser HD 202 II supra-aural headphones as an alternative headphone to enable more affordable hearing screening. Study 1 measured the equivalent threshold sound pressure levels (ETSPL) of the Sennheiser HD 202 II. Study 2 evaluated the attenuation of the headphones. Study 3 determined headphone characteristics by analyzing the total harmonic distortion (THD), frequency response and force of the headband. Twenty-five participants were included in study 1 and 15 in study 2 with ages ranging between 18 and 25. No participants were involved in study 3. The Sennheiser HD 202 II ETSPLs (250-16000 Hz) showed no significant effects on ETSPL for ear laterality, gender or age. Attenuation was not significantly different (p > 0.01) to TDH 39 except at 8000 Hz (p 3%. Sennheiser HD 202 II supra-aural headphones can be used as an affordable headphone for screening audiometry provided reported MPANLs, maximum intensities and ETSPL values are employed.

Neural processing of emotions in traumatized children treated with Eye Movement Desensitization and Reprocessing therapy: a hdEEG study

Science.gov (United States)

Trentini, Cristina; Pagani, Marco; Fania, Piercarlo; Speranza, Anna Maria; Nicolais, Giampaolo; Sibilia, Alessandra; Inguscio, Lucio; Verardo, Anna Rita; Fernandez, Isabel; Ammaniti, Massimo

2015-01-01

Eye Movement Desensitization and Reprocessing (EMDR) therapy has been proven efficacious in restoring affective regulation in post-traumatic stress disorder (PTSD) patients. However, its effectiveness on emotion processing in children with complex trauma has yet to be explored. High density electroencephalography (hdEEG) was used to investigate the effects of EMDR on brain responses to adults’ emotions on children with histories of early maltreatment. Ten school-aged children were examined before (T0) and within one month after the conclusion of EMDR (T1). hdEEGs were recorded while children passively viewed angry, afraid, happy, and neutral faces. Clinical scales were administered at the same time. Correlation analyses were performed to detect brain regions whose activity was linked to children’s traumatic symptom-related and emotional-adaptive problem scores. In all four conditions, hdEEG showed similar significantly higher activity on the right medial prefrontal and fronto-temporal limbic regions at T0, shifting toward the left medial and superior temporal regions at T1. Moreover, significant correlations were found between clinical scales and the same regions whose activity significantly differed between pre- and post-treatment. These preliminary results demonstrate that, after EMDR, children suffering from complex trauma show increased activity in areas implicated in high-order cognitive processing when passively viewing pictures of emotional expressions. These changes are associated with the decrease of depressive and traumatic symptoms, and with the improvement of emotional-adaptive functioning over time. PMID:26594183

THE NASA-UC ETA-EARTH PROGRAM. I. A SUPER-EARTH ORBITING HD 7924

International Nuclear Information System (INIS)

Howard, Andrew W.; Marcy, Geoffrey W.; Johnson, John Asher; Fischer, Debra A.; Giguere, Matthew J.; Isaacson, Howard; Wright, Jason T.; Henry, Gregory W.; Valenti, Jeff A.; Anderson, Jay; Piskunov, Nikolai E.

2009-01-01

We report the discovery of the first low-mass planet to emerge from the NASA-UC Eta-Earth Program, a super-Earth orbiting the K0 dwarf HD 7924. Keplerian modeling of precise Doppler radial velocities reveals a planet with minimum mass M P sin i = 9.26 M + in a P = 5.398 d orbit. Based on Keck-HIRES measurements from 2001 to 2008, the planet is robustly detected with an estimated false alarm probability of less than 0.001. Photometric observations using the Automated Photometric Telescopes at Fairborn Observatory show that HD 7924 is photometrically constant over the radial velocity period to 0.19 mmag, supporting the existence of the planetary companion. No transits were detected down to a photometric limit of ∼0.5 mmag, eliminating transiting planets with a variety of compositions. HD 7924b is one of only eight planets detected by the radial velocity technique with M P sin i + and as such is a member of an emerging family of low-mass planets that together constrain theories of planet formation.

THE ROTATION PERIOD OF HD-77581 (VELA X-1)

NARCIS (Netherlands)

ZUIDERWIJK, EJ

The rotation period of HD 77581, supergiant primary in the X-ray binary Vela X-1, is determined from an analysis of selected absorption line profiles. The rotation rate determined from He I line profiles is 0.67 +/- 0.04 times that of the binary angular velocity, corresponding to a rotation velocity

In their own words: reports of stigma and genetic discrimination by people at risk for Huntington disease in the International RESPOND-HD study.

Science.gov (United States)

Williams, Janet K; Erwin, Cheryl; Juhl, Andrew R; Mengeling, Michelle; Bombard, Yvonne; Hayden, Michael R; Quaid, Kimberly; Shoulson, Ira; Taylor, Sandra; Paulsen, Jane S

2010-09-01

Genetic discrimination may be experienced in the day-to-day lives of people at risk for Huntington disease (HD), encompassing occurrences in the workplace, when seeking insurance, within social relationships, and during other daily encounters. At-risk individuals who have tested either positive or negative for the genetic expansion that causes HD, as well as at-risk persons with a 50% chance for developing the disorder but have not had DNA testing completed the International RESPOND-HD (I-RESPOND-HD) survey. One of the study's purposes was to examine perceptions of genetic stigmatization and discrimination. A total of 412 out of 433 participants provided narrative comments, and 191 provided related codable narrative data. The core theme, Information Control, refers to organizational policies and interpersonal actions. This theme was found in narrative comments describing genetic discrimination perceptions across employment, insurance, social, and other situations. These reports were elaborated with five themes: What They Encountered, What They Felt, What Others Did, What They Did, and What Happened. Although many perceptions were coded as hurtful, this was not true in all instances. Findings document that reports of genetic discrimination are highly individual, and both policy as well as interpersonal factors contribute to the outcome of potentially discriminating events. (c) 2010 Wiley-Liss, Inc.

High-definition video display based on the FPGA and THS8200

Science.gov (United States)

Qian, Jia; Sui, Xiubao

2014-11-01

This paper presents a high-definition video display solution based on the FPGA and THS8200. THS8200 is a video decoder chip launched by TI company, this chip has three 10-bit DAC channels which can capture video data in both 4:2:2 and 4:4:4 formats, and its data synchronization can be either through the dedicated synchronization signals HSYNC and VSYNC, or extracted from the embedded video stream synchronization information SAV / EAV code. In this paper, we will utilize the address and control signals generated by FPGA to access to the data-storage array, and then the FPGA generates the corresponding digital video signals YCbCr. These signals combined with the synchronization signals HSYNC and VSYNC that are also generated by the FPGA act as the input signals of THS8200. In order to meet the bandwidth requirements of the high-definition TV, we adopt video input in the 4:2:2 format over 2×10-bit interface. THS8200 is needed to be controlled by FPGA with I2C bus to set the internal registers, and as a result, it can generate the synchronous signal that is satisfied with the standard SMPTE and transfer the digital video signals YCbCr into analog video signals YPbPr. Hence, the composite analog output signals YPbPr are consist of image data signal and synchronous signal which are superimposed together inside the chip THS8200. The experimental research indicates that the method presented in this paper is a viable solution for high-definition video display, which conforms to the input requirements of the new high-definition display devices.

Spectroscopic Variability of Supergiant Star HD14134, B3Ia

Indian Academy of Sciences (India)

Y. M. Maharramov

2017-06-19

Jun 19, 2017 ... the hot supergiant HD14134 studied in the present paper has a mass-loss rate of ...... tific program for the priority fields of research of the. National .... emission-line stars in the Large Magellanic Cloud, Astron. Astrophys., 158 ...

INFRARED TRANSMISSION SPECTROSCOPY OF THE EXOPLANETS HD 209458b AND XO-1b USING THE WIDE FIELD CAMERA-3 ON THE HUBBLE SPACE TELESCOPE

Energy Technology Data Exchange (ETDEWEB)

Deming, Drake; Wilkins, Ashlee [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); McCullough, Peter; Crouzet, Nicolas [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544-1001 (United States); Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Agol, Eric; Dobbs-Dixon, Ian [NASA Astrobiology Institute' s Virtual Planetary Laboratory (United States); Madhusudhan, Nikku [Yale Center for Astronomy and Astrophysics, Yale University, New Haven, CT 06511 (United States); Desert, Jean-Michel; Knutson, Heather A.; Line, Michael [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Gilliland, Ronald L. [Center for Exoplanets and Habitable Worlds, The Pennsylvania State University, University Park, PA 16802 (United States); Haynes, Korey [Department of Physics and Astronomy, George Mason University, Fairfax, VA 22030 (United States); Magic, Zazralt [Max-Planck-Institut fuer Astrophysik, D-85741 Garching (Germany); Mandell, Avi M.; Clampin, Mark [NASA' s Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Ranjan, Sukrit; Charbonneau, David [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Seager, Sara, E-mail: ddeming@astro.umd.edu [Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); and others

2013-09-10

Exoplanetary transmission spectroscopy in the near-infrared using the Hubble Space Telescope (HST) NICMOS is currently ambiguous because different observational groups claim different results from the same data, depending on their analysis methodologies. Spatial scanning with HST/WFC3 provides an opportunity to resolve this ambiguity. We here report WFC3 spectroscopy of the giant planets HD 209458b and XO-1b in transit, using spatial scanning mode for maximum photon-collecting efficiency. We introduce an analysis technique that derives the exoplanetary transmission spectrum without the necessity of explicitly decorrelating instrumental effects, and achieves nearly photon-limited precision even at the high flux levels collected in spatial scan mode. Our errors are within 6% (XO-1) and 26% (HD 209458b) of the photon-limit at a resolving power of {lambda}/{delta}{lambda} {approx} 70, and are better than 0.01% per spectral channel. Both planets exhibit water absorption of approximately 200 ppm at the water peak near 1.38 {mu}m. Our result for XO-1b contradicts the much larger absorption derived from NICMOS spectroscopy. The weak water absorption we measure for HD 209458b is reminiscent of the weakness of sodium absorption in the first transmission spectroscopy of an exoplanet atmosphere by Charbonneau et al. Model atmospheres having uniformly distributed extra opacity of 0.012 cm{sup 2} g{sup -1} account approximately for both our water measurement and the sodium absorption. Our results for HD 209458b support the picture advocated by Pont et al. in which weak molecular absorptions are superposed on a transmission spectrum that is dominated by continuous opacity due to haze and/or dust. However, the extra opacity needed for HD 209458b is grayer than for HD 189733b, with a weaker Rayleigh component.

Production of H,D(2s, 2p) by electron impact (0 - 2000 eV) on simple hydrogen containing molecules, ch. 2, A2

International Nuclear Information System (INIS)

Moehlman, G.R.; Heer, F.J. de

1977-01-01

Absolute emission cross sections of Ly-α (H,D(2p → 1s)) radiation have been determined for 0 - 2000 eV electrons incident on H 2 , HD, HCl, H 2 O, NH 3 and CH 4 . By means of the application of electric quenching, the excitation cross sections of H,D(2s) could be obtained from the increase of the resulting Ly-α radiation for these molecules. Only in the case of electrons on H 2 , D 2 and HD was excitation of H,D(2s) found

High Definition Television: A New Challenge for Telecommunication Policy.

Science.gov (United States)

Hongcharu, Boonchai

The telecommunications industry has now entered the most critical period of evolution in television technology since the introduction of color television. The transition to high definition television (HDTV), with related technologies such as semiconductors and computers, would mean a multi-billion dollar business for the telecommunications…

Interfacial Interactions and Nano structure Changes in DPPG/HD Monolayer at the Air/Water Interface

International Nuclear Information System (INIS)

Zhu, H.; Zhang, P.; Sun, R.; Hao, Ch.; Wang, J.; Zhu, H.; Zhang, T.; Zhang, P.; Li, Sh.

2015-01-01

Lung surfactant (LS) plays a crucial role in regulating surface tension during normal respiration cycles by decreasing the work associated with lung expansion and therefore decreases the metabolic energy consumed. Monolayer surfactant films composed of a mixture of phospholipids and spreading additives are of optional utility for applications in lung surfactant-based therapies. A simple, minimal model of such a lung surfactant system, composed of 1,2-dipalmitoyl-sn-glycero-3-[phosphor-rac-(1-glycerol)] (DPPG) and hexadecanol (HD), was prepared, and the surface pressure-area π-A) isotherms and nano structure characteristics of the binary mixture were investigated at the air/water interface using a combination of Langmuir-Blodgett (LB) and atomic force microscopy (AFM) techniques. Based on the regular solution theory, the miscibility and stability of the two components in the monolayer were analyzed in terms of compression modulusC_s"-1) , excess Gibbs free energy (δG"π_exc) , activity coefficients (γ), and interaction parameterζ. The results of this paper provide valuable insight into basic thermodynamics and nano structure of mixed DPPG/HD monolayers; it is helpful to understand the thermodynamic behavior of HD as spreading additive in LS monolayer with a view toward characterizing potential improvements to LS performance brought about by addition of HD to lung phospholipids

A LIKELY CLOSE-IN LOW-MASS STELLAR COMPANION TO THE TRANSITIONAL DISK STAR HD 142527

International Nuclear Information System (INIS)

Biller, Beth; Benisty, Myriam; Chauvin, Gael; Olofsson, Johan; Pott, Jörg-Uwe; Müller, André; Bonnefoy, Mickaël; Henning, Thomas; Lacour, Sylvestre; Thebault, Philippe; Juhász, Attila; Sicilia-Aguilar, Aurora; Tuthill, Peter; Crida, Aurelien

2012-01-01

With the uniquely high contrast within 0.''1 (Δmag(L') = 5-6.5 mag) available using Sparse Aperture Masking with NACO at Very Large Telescope, we detected asymmetry in the flux from the Herbig Fe star HD 142527 with a barycenter emission situated at a projected separation of 88 ± 5 mas (12.8 ± 1.5 AU at 145 pc) and flux ratios in H, K, and L' of 0.016 ± 0.007, 0.012 ± 0.008, and 0.0086 ± 0.0011, respectively (3σ errors), relative to the primary star and disk. After extensive closure-phase modeling, we interpret this detection as a close-in, low-mass stellar companion with an estimated mass of ∼0.1-0.4 M ☉ . HD 142527 has a complex disk structure, with an inner gap imaged in both the near and mid-IR as well as a spiral feature in the outer disk in the near-IR. This newly detected low-mass stellar companion may provide a critical explanation of the observed disk structure.

76 FR 12825 - List of Approved Spent Fuel Storage Casks: NUHOMS® HD System Revision 1; Confirmation of...

Science.gov (United States)

2011-03-09

... Storage Casks: NUHOMS[supreg] HD System Revision 1; Confirmation of Effective Date AGENCY: Nuclear... direct final rule amended the NRC's spent fuel storage regulations at Title 10 of the Code of Federal Regulations (10 CFR 72.214) to revise the NUHOMS[supreg] HD System listing to include Amendment Number 1 to...

Spectroscopic Binaries near the North Galactic Pole Paper 15: HD ...

Indian Academy of Sciences (India)

tribpo

Galactic Pole field he treated HD 106947 as if nothing were already known ... By good fortune a Palomar radial-velocity observing run in late 1986 fell near to a .... obvious to the naked eye as a grouping of fifth- and sixth-magnitude stars in an.

Spectroscopic Binaries near the North Galactic Pole Paper 24: HD ...

Indian Academy of Sciences (India)

R. Narasimhan (Krishtel eMaging Solutions)

Paper 24: HD 106104, 109281, 109463 and 110743. R. F. Griffin, The ... with photoelectric radial-velocity spectrometers for many years. They have ..... G3 V against the principal star's F9 V, so the two objects would very well pass for a physical ...

A modern study of HD 166734: a massive supergiant system

Science.gov (United States)

Mahy, L.; Damerdji, Y.; Gosset, E.; Nitschelm, C.; Eenens, P.; Sana, H.; Klotz, A.

2017-11-01

Aims: HD 166734 is an eccentric eclipsing binary system composed of two supergiant O-type stars, orbiting with a 34.5-day period. In this rare configuration for such stars, the two objects mainly evolve independently, following single-star evolution so far. This system provides a chance to study the individual parameters of two supergiant massive stars and to derive their real masses. Methods: An intensive monitoring was dedicated to HD 166734. We analyzed mid- and high-resolution optical spectra to constrain the orbital parameters of this system. We also studied its light curve for the first time, obtained in the VRI filters. Finally, we disentangled the spectra of the two stars and modeled them with the CMFGEN atmosphere code in order to determine the individual physical parameters. Results: HD 166734 is a O7.5If+O9I(f) binary. We confirm its orbital period but we revise the other orbital parameters. In comparison to what we found in the literature, the system is more eccentric and, now, the hottest and the most luminous component is also the most massive one. The light curve exhibits only one eclipse and its analysis indicates an inclination of 63.0° ± 2.7°. The photometric analysis provides us with a good estimation of the luminosities of the stars, and therefore their exact positions in the Hertzsprung-Russell diagram. The evolutionary and the spectroscopic masses show good agreement with the dynamical masses of 39.5 M⊙ for the primary and 33.5 M⊙ for the secondary, within the uncertainties. The two components are both enriched in helium and in nitrogen and depleted in carbon. In addition, the primary also shows a depletion in oxygen. Their surface abundances are however not different from those derived from single supergiant stars, yielding, for both components, an evolution similar to that of single stars. Based on observations collected at the European Southern Observatory (La Silla, Chile) with FEROS and TAROT and on data collected at the San Pedro

The new Be-type star HD 147196 in the Rho Ophiuchi dark cloud region

Science.gov (United States)

The, P. S.; Perez, M. R.; De Winter, D.; Van Den Ancker, M. E.

1993-01-01

The newly discovered hot-emission line star, HD 147196 in the Rho Oph dark cloud region was observed spectroscopically and photometrically and high and low resolution IUE spectra were obtained. The finding of Irvine (1990) that this relatively bright star show its H-alpha-line in emission is confirmed. Previous H-alpha-surveys of the Rho Oph star-forming region did not detect HD 147196 as an H-alpha-emission star, meaning that it must recently be very active and has perhaps transformed itself from a B-type star at shell phase to a Be-phase. The Mg II h + k resonance lines are in absorption and they appear to be interstellar in nature, which means that either the abundance of Mg in the extended atmosphere of the star is low or that the shell is not extended enough to produce emission lines of Mg II. Photometric observations of this B8 V type star do not show any variations during at least the years covered by our monitoring or any excess of NIR radiation in its spectral energy distribution up to the M-passband at 4.8 microns.

VizieR Online Data Catalog: Radial velocities for the HD 3167 system (Christiansen+, 2017)

Science.gov (United States)

Christiansen, J. L.; Vanderburg, A.; Burt, J.; Fulton, B. J.; Batygin, K.; Benneke, B.; Brewer, J. M.; Charbonneau, D.; Ciardi, D. R.; Cameron, A. C.; Coughlin, J. L.; Crossfield, I. J. M.; Dressing, C.; Greene, T. P.; Howard, A. W.; Latham, D. W.; Molinari, E.; Mortier, A.; Mullally, F.; Pepe, F.; Rice, K.; Sinukoff, E.; Sozzetti, A.; Thompson, S. E.; Udry, S.; Vogt, S. S.; Barman, T. S.; Batalha, N. E.; Bouchy, F.; Buchhave, L. A.; Butler, R. P.; Cosentino, R.; Dupuy, T. J.; Ehrenreich, D.; Fiorenzano, A.; Hansen, B. M. S.; Henning, T.; Hirsch, L.; Holden, B. P.; Isaacson, H. T.; Johnson, J. A.; Knutson, H. A.; Kosiarek, M.; Lopez-Morales, M.; Lovis, C.; Malavolta, L.; Mayor, M.; Micela, G.; Motalebi, F.; Petigura, E.; Phillips, D. F.; Piotto, G.; Rogers, L. A.; Sasselov, D.; Schlieder, J. E.; Segransan, D.; Watson, C. A.; Weiss, L. M.

2018-06-01

The final data set includes observations obtained with Keck/HIRES, Automated Planet Finder (APF)/Levy, and HARPS-N. Our observational setup for both Keck/HIRES and the APF/Levy was essentially identical to those described in Fulton et al. (2016, J/ApJ/830/46) and Burt et al. (2014ApJ...789..114B). We collected a total of 60 RV measurements using Keck/HIRES (Vogt et al. 1994SPIE.2198..362V), and 116 measurements using the Levy Spectrograph on the APF (Radovan et al. 2014SPIE.9145E..2BR; Vogt et al. 2014PASP..126..359V) at Lick Observatory between 2016 July 7 and 2016 December 2. We also observed HD 3167 with the HARPS-N spectrograph (Cosentino et al. 2012SPIE.8446E..1VC) located at the 3.58 m Telescopio Nazionale Galileo on the island of La Palma, Spain. HARPS-N is a stabilized spectrograph designed for precise RV measurements. We observed HD 3167 76 times between 2016 July 7 (independently beginning the same night as the HIRES/APF campaign) and 2016 December 7, obtaining high-resolution optical spectra with a spectral resolving power of R=115000. (1 data file).

Imaging actinic keratosis by high-definition optical coherence tomography. Histomorphologic correlation

DEFF Research Database (Denmark)

Boone, Marc A L M; Norrenberg, Sarah; Jemec, Gregor B E

2013-01-01

With the continued development of non-invasive therapies for actinic keratosis such as PDT and immune therapies, the non-invasive diagnosis and monitoring become increasingly relevant. High-definition optical coherence tomography is a high-resolution imaging tool, with micrometre resolution in both...... transversal and axial directions, enable to visualize individual cells up to a depth of around 570 μm filling the imaging gap between conventional optical coherence tomography and reflectance confocal microscopy. We sought to determine the feasibility of detecting and grading of actinic keratosis...... by this technique using criteria defined for reflectance confocal microscopy compared to histology. In this pilot study, skin lesions of 17 patients with a histologically proven actinic keratosis were imaged by high-definition optical coherence tomography just before excision and images analysed qualitatively...

XUV-laser spectroscopy of HD at 92-98 nm.

NARCIS (Netherlands)

Hinnen, P.C.; Werners, S.E.; Stolte, S.; Hogervorst, W.; Ubachs, W.M.G.

1995-01-01

Sub-Doppler excitation spectra of HD have been recorded in the range 9298 nm with the use of a narrow-band and tunable extreme ultraviolet laser in combination with a molecular beam. Frequencies of 147 transitions to the B 1u+, C 1 u, and EF 1g+ states have been calibrated with an average absolute

Effect of an 8K ultra-high-definition television system in a case of laparoscopic gynecologic surgery.

Science.gov (United States)

Aoki, Yoichi; Matsuura, Masahiko; Chiba, Toshio; Yamashita, Hiromasa

2017-09-01

Various endoscopic devices have been developed for advanced minimally invasive surgery. We recently applied a new 8K ultra-high-definition television system during laparoscopic treatment of endometriosis. The procedure, which is described in detail, stands as the first reported application of an 8K ultra-high-definition system for laparoscopic gynecologic surgery. Comparison is made between depiction of the lesion by the new system and depiction by a full high-definition system. Improved diagnostic accuracy resulted from the increased image resolution, and we believe that this and other advantages will lead to widespread acceptance and further application of 8K ultra-high-definition systems in the field of gynecologic surgery.

Spectroscopic abundance analyses of the 3He stars HD 185330 and 3 Cen A

Science.gov (United States)

Sadakane, Kozo; Nishimura, Masayoshi

2018-04-01

Abundances of 21 elements in two 3He stars, HD 185330 and 3 Cen A, have been analysed relative to the well-studied sharp-lined B3 V star ι Her. Six elements (P, Ti, Mn, Fe, Ni, and Br) are over-abundant in these two peculiar stars, while six elements (C, O, Mg, Al, S, and Cl) are under-abundant. Absorption lines of the two rarely observed heavy elements Br II and Kr II are detected in both stars and these elements are both over-abundant. The centroid wavelengths of the Ca II infrared triplet lines in these stars are redshifted relative to those lines in ι Her and the presence of heavy isotopes of Ca (mass number 44-46) in these two stars is confirmed. In spite of these similarities, there are several remarkable differences in abundance pattern between these two stars. N is under-abundant in HD 185330, as in many Hg-Mn stars, while it is significantly over-abundant in 3 Cen A. P and Ga are both over-abundant in 3 Cen A, while only P is over-abundant and no trace of absorption line of Ga II can be found in HD 185330. Large over-abundances of Kr and Xe are found in both stars, while the abundance ratio Kr/Xe is significantly different between them (-1.4 dex in HD 185330 and +1.2 dex in 3 Cen A). Some physical explanations are needed to account for these qualitative differences.

Arene-mercury complexes stabilized by gallium chloride: relative rates of H/D and arene exchange.

Science.gov (United States)

Branch, Catherine S; Barron, Andrew R

2002-11-27

We have previously proposed that the Hg(arene)(2)(GaCl(4))(2) catalyzed H/D exchange reaction of C(6)D(6) with arenes occurs via an electrophilic aromatic substitution reaction in which the coordinated arene protonates the C(6)D(6). To investigate this mechanism, the kinetics of the Hg(C(6)H(5)Me)(2)(GaCl(4))(2) catalyzed H/D exchange reaction of C(6)D(6) with naphthalene has been studied. Separate second-order rate constants were determined for the 1- and 2-positions on naphthalene; that is, the initial rate of H/D exchange = k(1i)[Hg][C-H(1)] + k(2i)[Hg][C-H(2)]. The ratio of k(1i)/k(2i) ranges from 11 to 2.5 over the temperature range studied, commensurate with the proposed electrophilic aromatic substitution reaction. Observation of the reactions over an extended time period shows that the rates change with time, until they again reach a new and constant second-order kinetics regime. The overall form of the rate equation is unchanged: final rate = k(1f)[Hg][C-H(1)] + k(2f)[Hg][C-H(2)]. This change in the H/D exchange is accompanied by ligand exchange between Hg(C(6)D(6))(2)(GaCl(4))(2) and naphthalene to give Hg(C(10)H(8))(2)(GaCl(4))(2,) that has been characterized by (13)C CPMAS NMR and UV-visible spectroscopy. The activation parameters for the ligand exchange may be determined and are indicative of a dissociative reaction and are consistent with our previously calculated bond dissociation for Hg(C(6)H(6))(2)(AlCl(4))(2). The initial Hg(arene)(2)(GaCl(4))(2) catalyzed reaction of naphthalene with C(6)D(6) involves the deuteration of naphthalene by coordinated C(6)D(6); however, as ligand exchange progresses, the pathway for H/D exchange changes to where the protonation of C(6)D(6) by coordinated naphthalene dominates. The site selectivity for the H/D exchange is initially due to the electrophilic aromatic substitution of naphthalene. As ligand exchange occurs, this selectivity is controlled by the activation of the naphthalene C-H bonds by mercury.

GPI Spectroscopy of the Mass, Age, and Metallicity Benchmark Brown Dwarf HD 4747 B

Science.gov (United States)

Crepp, Justin R.; Principe, David A.; Wolff, Schuyler; Giorla Godfrey, Paige A.; Rice, Emily L.; Cieza, Lucas; Pueyo, Laurent; Bechter, Eric B.; Gonzales, Erica J.

2018-02-01

The physical properties of brown dwarf companions found to orbit nearby, solar-type stars can be benchmarked against independent measures of their mass, age, chemical composition, and other parameters, offering insights into the evolution of substellar objects. The TRENDS high-contrast imaging survey has recently discovered a (mass/age/metallicity) benchmark brown dwarf orbiting the nearby (d = 18.69 ± 0.19 pc), G8V/K0V star HD 4747. We have acquired follow-up spectroscopic measurements of HD 4747 B using the Gemini Planet Imager to study its spectral type, effective temperature, surface gravity, and cloud properties. Observations obtained in the H-band and K 1-band recover the companion and reveal that it is near the L/T transition (T1 ± 2). Fitting atmospheric models to the companion spectrum, we find strong evidence for the presence of clouds. However, spectral models cannot satisfactorily fit the complete data set: while the shape of the spectrum can be well-matched in individual filters, a joint fit across the full passband results in discrepancies that are a consequence of the inherent color of the brown dwarf. We also find a 2σ tension in the companion mass, age, and surface gravity when comparing to evolutionary models. These results highlight the importance of using benchmark objects to study “secondary effects” such as metallicity, non-equilibrium chemistry, cloud parameters, electron conduction, non-adiabatic cooling, and other subtleties affecting emergent spectra. As a new L/T transition benchmark, HD 4747 B warrants further investigation into the modeling of cloud physics using higher resolution spectroscopy across a broader range of wavelengths, polarimetric observations, and continued Doppler radial velocity and astrometric monitoring.

HD 91669B: A NEW BROWN DWARF CANDIDATE FROM THE MCDONALD OBSERVATORY PLANET SEARCH

International Nuclear Information System (INIS)

Wittenmyer, Robert A.; Endl, Michael; Cochran, William D.; Ramirez, Ivan; MacQueen, Phillip J.; Shetrone, Matthew; Reffert, Sabine

2009-01-01

We report the detection of a brown dwarf candidate orbiting the metal-rich K dwarf HD 91669, based on radial-velocity data from the McDonald Observatory Planet Search. HD 91669b is a substellar object in an eccentric orbit (e = 0.45) at a separation of 1.2 AU. The minimum mass of 30.6M Jup places this object firmly within the brown dwarf desert for inclinations i ∼> 23 0 . This is the second rare close-in brown dwarf candidate discovered by the McDonald planet search program.

Results of a cooperative study for the evaluation of the barium meal Falibaryt HD

International Nuclear Information System (INIS)

Reisinger, W.; Liess, G.; Beckmann, D.; Block, H.G.; Dietze, R.; Grosche, N.; Hall, E.; Lasch, G.; Knoth, H.J.; Kroeger, W.

1986-01-01

The diagnostic capabilities of radiologic investigations of the stomach in double contrast can be significantly improved with high-density low-viscosity barium meals. In the GDR the barium meal Falibaryt HD with a barium sulfate content of 215 g per 100 ml suspension has been developed. In nearly 1,000 radiologic investigations of the stomach (81% in relaxation with spasmolytics, 66% without hypotony) all fine structures were well imaged and the preparation therefore is comparable with the best barium meals presently on the market. (author)

Delay Tolerance: A Therapeutic Possibility for AD/HD?

Directory of Open Access Journals (Sweden)

Edmund J. S. Sonuga-Barke

2004-01-01

on these two insights to explore the possibility that the motivational alterations underpinning delay aversion can be modified through specific training regimes in a way equivalent to that found with executive and attentional training. The requirements for such an approach are set out. Delay fading is proposed as a possible basis for reorganizing delay experience, altering the incentive value of delay (e.g., increasing tolerance for delay, thereby reducing AD/HD symptoms.

Probing the Gaseous Structure of a β-Hairpin Peptide with H/D Exchange and Electron Capture Dissociation.

Science.gov (United States)

Straus, Rita N; Jockusch, Rebecca A

2017-02-01

An improved understanding of the extent to which native protein structure is retained upon transfer to the gas phase promises to enhance biological mass spectrometry, potentially streamlining workflows and providing fundamental insights into hydration effects. Here, we investigate the gaseous conformation of a model β-hairpin peptide using gas-phase hydrogen-deuterium (H/D) exchange with subsequent electron capture dissociation (ECD). Global gas-phase H/D exchange levels, and residue-specific exchange levels derived from ECD data, are compared among the wild type 16-residue peptide GB1p and several variants. High protection from H/D exchange observed for GB1p, but not for a truncated version, is consistent with the retention of secondary structure of GB1p in the gas phase or its refolding into some other compact structure. Four alanine mutants that destabilize the hairpin in solution show levels of protection similar to that of GB1p, suggesting collapse or (re)folding of these peptides upon transfer to the gas phase. These results offer a starting point from which to understand how a key secondary structural element, the β-hairpin, is affected by transfer to the gas phase. This work also demonstrates the utility of a much-needed addition to the tool set that is currently available for the investigation of the gaseous conformation of biomolecules, which can be employed in the future to better characterize gaseous proteins and protein complexes. Graphical Abstract ᅟ.

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study

Directory of Open Access Journals (Sweden)

Stefan Klöppel

2015-10-01

Interpretation: Our findings provide evidence for active compensatory processes in premanifest-HD for cognitive demands and suggest a higher vulnerability of the left hemisphere to the effects of regional atrophy.

Complex Spiral Structure in the HD 100546 Transitional Disk as Revealed by GPI and MagAO

Energy Technology Data Exchange (ETDEWEB)

Follette, Katherine B.; Macintosh, Bruce; Mullen, Wyatt; Bailey, Vanessa P. [Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics, Stanford University, Stanford, CA, 94305 (United States); Rameau, Julien [Institut de Recherche sur les Exoplanètes, Départment de Physique, Université de Montréal, Montréal QC H3C 3J7 (Canada); Dong, Ruobing; Close, Laird M.; Males, Jared R.; Morzinski, Katie M. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Pueyo, Laurent; Perrin, Marshall [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Duchêne, Gaspard; Fung, Jeffrey; Wang, Jason [Astronomy Department, University of California, Berkeley, Berkeley CA 94720 (United States); Leonard, Clare; Spiro, Elijah [Physics and Astronomy Department, Amherst College, 21 Merrill Science Drive, Amherst, MA 01002 (United States); Marois, Christian [National Research Council of Canada Herzberg, 5071 West Saanich Road, Victoria, BC V9E 2E7 (Canada); Millar-Blanchaer, Maxwell A. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91125 (United States); Ammons, S. Mark [Lawrence Livermore National Laboratory, Livermore, CA 94551 (United States); Barman, Travis [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States); and others

2017-06-01

We present optical and near-infrared high-contrast images of the transitional disk HD 100546 taken with the Magellan Adaptive Optics system (MagAO) and the Gemini Planet Imager (GPI). GPI data include both polarized intensity and total intensity imagery, and MagAO data are taken in Simultaneous Differential Imaging mode at H α . The new GPI H -band total intensity data represent a significant enhancement in sensitivity and field rotation compared to previous data sets and enable a detailed exploration of substructure in the disk. The data are processed with a variety of differential imaging techniques (polarized, angular, reference, and simultaneous differential imaging) in an attempt to identify the disk structures that are most consistent across wavelengths, processing techniques, and algorithmic parameters. The inner disk cavity at 15 au is clearly resolved in multiple data sets, as are a variety of spiral features. While the cavity and spiral structures are identified at levels significantly distinct from the neighboring regions of the disk under several algorithms and with a range of algorithmic parameters, emission at the location of HD 100546 “ c ” varies from point-like under aggressive algorithmic parameters to a smooth continuous structure with conservative parameters, and is consistent with disk emission. Features identified in the HD 100546 disk bear qualitative similarity to computational models of a moderately inclined two-armed spiral disk, where projection effects and wrapping of the spiral arms around the star result in a number of truncated spiral features in forward-modeled images.

Development, validation, and application of ELISA for detection of anti-HD105 antibodies in pre-clinical safety evaluation using monkeys.

Science.gov (United States)

Choi, Woo Hyuck; Jo, Hye Ryun; Jeon, Eun-Jeong; Youm, So-Young; Jeon, Jang Su; Son, Yong-Gyu; You, Weon-Kyoo; Koh, Woo Suk; Lee, Sang Hoon; Kim, Sang Kyum

2016-11-30

Unwanted immunogenicity of protein therapeutics can result in severe side effects and should be assessed in animals before applying the treatment to humans. Monkeys are the most relevant choice for pre-clinical toxicity testing of antibody-based therapeutics. To assess the immunogenicity of HD105, a novel antibody therapeutic that targets both vascular endothelial growth factor and Delta-like-ligand 4, a bridging enzyme-linked immunosorbent assay was developed as an anti-drug antibody (ADA) assay and validated for use in pre-clinical studies using non-human primates. This method was found to have suitable assay sensitivity, intra- and inter-assay precision, confirmation, drug tolerance, recovery, and sample stability for measuring ADA in monkey serum samples. The results showed that ADA elevation occurred following repeated doses of HD105, and that ADA production was negatively associated with serum HD105 concentration. These results suggest that intravenous administration of HD105 induces production of ADA in monkeys and that the detection of ADA may be negatively influenced by free HD105 in serum. Copyright © 2016 Elsevier B.V. All rights reserved.

A Decade of H α Transits for HD 189733 b: Stellar Activity versus Absorption in the Extended Atmosphere

Energy Technology Data Exchange (ETDEWEB)

Cauley, P. Wilson; Redfield, Seth [Wesleyan University, Astronomy Department, Van Vleck Observatory, 96 Foss Hill Drive, Middletown, CT 06459 (United States); Jensen, Adam G., E-mail: pcauley@wesleyan.edu [University of Nebraska-Kearney, Department of Physics and Astronomy, 24011 11th Avenue, Kearney, NE 68849 (United States)

2017-05-01

HD 189733 b is one of the most well studied exoplanets due to its large transit depth and host star brightness. The focus on this object has produced a number of high-cadence transit observations using high-resolution optical spectrographs. Here we present an analysis of seven full H α transits of HD 189733 b using HARPS on the 3.6 meter La Silla telescope and HIRES on Keck I, taken over the course of nine years from 2006 to 2015. H α transmission signals are analyzed as a function of the stellar activity level, as measured using the normalized core flux of the Ca ii H and K lines. We find strong variations in the strength of the H α transmission spectrum from epoch to epoch. However, there is no clear trend between the Ca ii core emission and the strength of the in-transit H α signal, although the transit showing the largest absorption value also occurs when the star is the most active. We present simulations of the in-transit contrast effect and find that the planet must consistently transit active latitudes with very strong facular and plage emission regions in order to reproduce the observed line strengths. We also investigate the measured velocity centroids with models of planetary rotation and show that the small line profile velocities could be due to large velocities in the upper atmosphere of the planet. Overall, we find it more likely that the measured H α signals arise in the extended planetary atmosphere, although a better understanding of active region emission for active stars such as HD 189733 is needed.

In Planta Single-Molecule Pull-Down Reveals Tetrameric Stoichiometry of HD-ZIPIII:LITTLE ZIPPER Complexes.

Science.gov (United States)

Husbands, Aman Y; Aggarwal, Vasudha; Ha, Taekjip; Timmermans, Marja C P

2016-08-01

Deciphering complex biological processes markedly benefits from approaches that directly assess the underlying biomolecular interactions. Most commonly used approaches to monitor protein-protein interactions typically provide nonquantitative readouts that lack statistical power and do not yield information on the heterogeneity or stoichiometry of protein complexes. Single-molecule pull-down (SiMPull) uses single-molecule fluorescence detection to mitigate these disadvantages and can quantitatively interrogate interactions between proteins and other compounds, such as nucleic acids, small molecule ligands, and lipids. Here, we establish SiMPull in plants using the HOMEODOMAIN LEUCINE ZIPPER III (HD-ZIPIII) and LITTLE ZIPPER (ZPR) interaction as proof-of-principle. Colocalization analysis of fluorophore-tagged HD-ZIPIII and ZPR proteins provides strong statistical evidence of complex formation. In addition, we use SiMPull to directly quantify YFP and mCherry maturation probabilities, showing these differ substantially from values obtained in mammalian systems. Leveraging these probabilities, in conjunction with fluorophore photobleaching assays on over 2000 individual complexes, we determined HD-ZIPIII:ZPR stoichiometry. Intriguingly, these complexes appear as heterotetramers, comprising two HD-ZIPIII and two ZPR molecules, rather than heterodimers as described in the current model. This surprising result raises new questions about the regulation of these key developmental factors and is illustrative of the unique contribution SiMPull is poised to make to in planta protein interaction studies. © 2016 American Society of Plant Biologists. All rights reserved.

The period of the magnetic star HD 133 029

International Nuclear Information System (INIS)

Panov, K.; Schoeneich, W.

1976-01-01

The period of 0.741285 days for the light variability of the magnetic star HD 133 029 was obtained from UBV observations. The observations of the effective magnetic field by Babcock show variations with a period of 0.7447 days. A small change of the period and a slow change of the magnitude of this magnetic star seems to be present. (author)

Optical intensity modulation direct detection versus heterodyne detection: A high-SNR capacity comparison

KAUST Repository

Chaaban, Anas

2016-09-15

An optical wireless communications system which employs either intensity-modulation and direct-detection (IM-DD) or heterodyne detection (HD) is considered. IM-DD has lower complexity and cost than HD, but on the other hand, has lower capacity. It is therefore interesting to investigate the capacity gap between the two systems. The main focus of this paper is to investigate this gap at high SNR. Bounds on this gap are established for two cases: between IM-DD and HD, and between IM-DD and an HD-PAM which is an HD system employing pulse-amplitude modulation (PAM). While the gap between IM-DD and HD increases as the signal-to-noise ratio (SNR) increases, the gap between IM-DD and an HD-PAM is upper bounded by a constant at high SNR. © 2015 IEEE.

Optical intensity modulation direct detection versus heterodyne detection: A high-SNR capacity comparison

KAUST Repository

Chaaban, Anas; Alouini, Mohamed-Slim

2016-01-01

An optical wireless communications system which employs either intensity-modulation and direct-detection (IM-DD) or heterodyne detection (HD) is considered. IM-DD has lower complexity and cost than HD, but on the other hand, has lower capacity. It is therefore interesting to investigate the capacity gap between the two systems. The main focus of this paper is to investigate this gap at high SNR. Bounds on this gap are established for two cases: between IM-DD and HD, and between IM-DD and an HD-PAM which is an HD system employing pulse-amplitude modulation (PAM). While the gap between IM-DD and HD increases as the signal-to-noise ratio (SNR) increases, the gap between IM-DD and an HD-PAM is upper bounded by a constant at high SNR. © 2015 IEEE.

Impact of Constant Rate Factor on Objective Video Quality Assessment

Directory of Open Access Journals (Sweden)

Juraj Bienik

2017-01-01

Full Text Available This paper deals with the impact of constant rate factor value on the objective video quality assessment using PSNR and SSIM metrics. Compression efficiency of H.264 and H.265 codecs defined by different Constant rate factor (CRF values was tested. The assessment was done for eight types of video sequences depending on content for High Definition (HD, Full HD (FHD and Ultra HD (UHD resolution. Finally, performance of both mentioned codecs with emphasis on compression ratio and efficiency of coding was compared.

Bound energy levels at the n=2 dissociation threshold in HD

NARCIS (Netherlands)

Pielage, T.G.P.; de Lange, A.; Brandi, F.; Ubachs, W.M.G.

2002-01-01

Level energies of g symmetry states lying just below the n = 2 dissociation threshold have been determined in a XUV + IR multi-step laser excitation experiment in HD, with an absolute accuracy of the excitation energy of 0.015 cm

SU-F-J-20: Commissioning and Acceptance Testing of the C-Rad CatalystHD Surface Imaging System

International Nuclear Information System (INIS)

Stanley, D; Rasmussen, K; Kirby, N; Papanikolaou, N; Gutierrez, A

2016-01-01

Introduction: With the increasing use of surface-based, nonionizing image-guided radiotherapy (IGRT) systems, a comprehensive set of clinical acceptance and commissioning procedures are needed to ensure correct functionality and proper clinical integration. Although TG-147 provides a specific set of parameters, measurement methodologies have yet to be described. The aim of this study was to provide a comprehensive overview of the commissioning and acceptance analysis performed for the C-Rad CatalystHD imaging system. Methods and Materials: Methodology for the commissioning and acceptance of the C-Rad CatalystHD imaging system was developed using commercially available clinical equipment. Following TG-147 guidelines, the following tests were performed: integration of peripheral equipment, system drift, static spatial reproducibility and localization accuracy, static end-to-end analysis, static rotational accuracy, dynamic spatial accuracy, dynamic temporal accuracy, dynamic radiation delivery and a comprehensive end-to-end analysis. Results: The field of view (FOV) of the CatalystHD was 105×109×83 cm3 in the lateral, longitudinal and vertical directions. For thermal equilibrium and system drift, a thermal drift of 1.0mm was noted. A 45 min warmup time is recommended if the system has been shut off an extended period of time (>24 hours) before the QA procedure to eliminate any thermal drift. Spatial reproducibility was found to be 0.05±0.03 mm using a rigid phantom. For the static localization accuracy, system agreement with couch shifts was within 0.1±0.1 mm and positioning agreement with kV-CBCT was 0.16±0.10 mm. For static rotational accuracy, system agreement with a high precision rotational stage (0.01 deg precision) was within 0.10±0.07 deg. Dynamic spatial and temporal localization accuracy was found to be within 0.2±0.1 mm. Conclusion: A comprehensive commissioning and acceptance study was performed using commercially available phantoms and in

Project VeSElkA: a search for the vertical stratification of element abundances in HD 157087

Science.gov (United States)

Khalack, V.

2018-06-01

The new spectropolarimetric spectra of HD 157087 obtained recently with ESPaDOnS (Echelle SpectroPolarimetric Device for Observations of Stars) at the Canada-France-Hawaii Telescope are analysed to verify the nature of this object. The fundamental stellar parameters Teff = 8882 K, log g = 3.57 were obtained for HD 157087 from the analysis of nine Balmer line profiles in two available spectra. A comparison of the results of our abundance analysis with previously published data shows a variability of the average abundance with time for some chemical species, while the abundances of other elements remain almost constant. The abundance analysis also reveals evidence of a significant abundance increase towards the deeper atmospheric layers for C, S, Ca, Sc, V, Cr, Mn, Co, Ni and Zr. Together with the discovered enhanced abundance of Ca and Sc, this finding contradicts the classification of HD 157087 as a marginal Am star. An analysis of the available measurements of radial velocity revealed long- and short-period variations. The long-period variation supports the idea that HD 157087 is an astrometric binary system with a period longer than 6 yr. The presence of the short-period variation of Vr, as well as the detection of the temporal variation of the average abundance, suggests that HD 157087 may be a triple system, in which a short-period binary rotates around a third star. In this case, the short-period binary may consist of slowly rotating Am and A (or Ap with a weak magnetic field) stars that have similar effective temperatures and surface gravities, but different abundance peculiarities.

Combining high-speed SVM learning with CNN feature encoding for real-time target recognition in high-definition video for ISR missions

Science.gov (United States)

Kroll, Christine; von der Werth, Monika; Leuck, Holger; Stahl, Christoph; Schertler, Klaus

2017-05-01

For Intelligence, Surveillance, Reconnaissance (ISR) missions of manned and unmanned air systems typical electrooptical payloads provide high-definition video data which has to be exploited with respect to relevant ground targets in real-time by automatic/assisted target recognition software. Airbus Defence and Space is developing required technologies for real-time sensor exploitation since years and has combined the latest advances of Deep Convolutional Neural Networks (CNN) with a proprietary high-speed Support Vector Machine (SVM) learning method into a powerful object recognition system with impressive results on relevant high-definition video scenes compared to conventional target recognition approaches. This paper describes the principal requirements for real-time target recognition in high-definition video for ISR missions and the Airbus approach of combining an invariant feature extraction using pre-trained CNNs and the high-speed training and classification ability of a novel frequency-domain SVM training method. The frequency-domain approach allows for a highly optimized implementation for General Purpose Computation on a Graphics Processing Unit (GPGPU) and also an efficient training of large training samples. The selected CNN which is pre-trained only once on domain-extrinsic data reveals a highly invariant feature extraction. This allows for a significantly reduced adaptation and training of the target recognition method for new target classes and mission scenarios. A comprehensive training and test dataset was defined and prepared using relevant high-definition airborne video sequences. The assessment concept is explained and performance results are given using the established precision-recall diagrams, average precision and runtime figures on representative test data. A comparison to legacy target recognition approaches shows the impressive performance increase by the proposed CNN+SVM machine-learning approach and the capability of real-time high-definition

Fabrication of high edge-definition steel-tape gratings for optical encoders

Science.gov (United States)

Ye, Guoyong; Liu, Hongzhong; Yan, Jiawei; Ban, Yaowen; Fan, Shanjin; Shi, Yongsheng; Yin, Lei

2017-10-01

High edge definition of a scale grating is the basic prerequisite for high measurement accuracy of optical encoders. This paper presents a novel fabrication method of steel tape gratings using graphene oxide nanoparticles as anti-reflective grating strips. Roll-to-roll nanoimprint lithography is adopted to manufacture the steel tape with hydrophobic and hydrophilic pattern arrays. Self-assembly technology is employed to obtain anti-reflective grating strips by depositing the graphene oxide nanoparticles on hydrophobic regions. A thin SiO2 coating is deposited on the grating to protect the grating strips. Experimental results confirm that the proposed fabrication process enables a higher edge definition in making steel-tape gratings, and the new steel tape gratings offer better performance than conventional gratings.

Tracking Advanced Planetary Systems (TAPAS) with HARPS-N. VI. HD 238914 and TYC 3318-01333-1: two more Li-rich giants with planets

Science.gov (United States)

Adamów, M.; Niedzielski, A.; Kowalik, K.; Villaver, E.; Wolszczan, A.; Maciejewski, G.; Gromadzki, M.

2018-05-01

Context. We present the latest results of our search for planets with HARPS-N at the 3.6 m Telescopio Nazionale Galileo under the Tracking Advanced Planetary Systems project: an in-depth study of the 15 most Li abundant giants from the PennState - Toruń Planet Search sample. Aims: Our goals are first, to obtain radial velocities of the most Li-rich giants we identified in our sample to search for possible low-mass substellar companions, and second, to perform an extended spectral analysis to define the evolutionary status of these stars. Methods: This work is based on high-resolution spectra obtained with the Hobby-Eberly Telescope and its High Resolution Spectrograph, and with the HARPS-N spectrograph at the Telescopio Nazionale Galileo. Two stars, HD 181368 and HD 188214, were also observed with UVES at the VLT to determine beryllium abundances. Results: We report i) the discovery of two new planetary systems around the Li-rich giant stars: HD 238914 and TYC 3318-01333-1 (a binary system); ii) reveal a binary Li-rich giant, HD 181368; iii) although our current phase coverage is not complete, we suggest the presence of planetary mass companions around TYC 3663-01966-1 and TYC 3105-00152-1; iv) we confirm the previous result for BD+48 740 and present updated orbital parameters, and v) we find a lack of a relation between the Li enhancement and the Be abundance for the stars HD 181368 and HD 188214, for which we acquired blue spectra. Conclusions: We found seven stars with stellar or potential planetary companions among the 15 Li-rich giant stars. The binary star frequency of the Li-rich giants in our sample appears to be normal, but the planet frequency is twice that of the general sample, which suggests a possible connection between hosting a companion and enhanced Li abundance in giant stars. We also found most of the companions orbits to be highly eccentric. Based on observations obtained with the Hobby-Eberly Telescope, which is a joint project of the

KEPLER-21b: A 1.6 R{sub Earth} PLANET TRANSITING THE BRIGHT OSCILLATING F SUBGIANT STAR HD 179070

Energy Technology Data Exchange (ETDEWEB)

Howell, Steve B. [National Optical Astronomy Observatory, Tucson, AZ 85719 (United States); Rowe, Jason F.; Bryson, Stephen T. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Quinn, Samuel N. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Marcy, Geoffrey W.; Isaacson, Howard [Department of Astronomy, University of California, Berkeley, CA 94720 (United States); Ciardi, David R. [NASA Exoplanet Science Institute/Caltech, Pasadena, CA 91125 (United States); Chaplin, William J.; Elsworth, Yvonne [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Metcalfe, Travis S. [High Altitude Observatory and Scientific Computing Division, National Center for Atmospheric Research, Boulder, CO 80307 (United States); Monteiro, Mario J. P. F. G. [Centro de Astrofisica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Appourchaux, Thierry [Institut d' Astrophysique Spatiale, Universite Paris XI-CNRS (UMR8617), Batiment 121, 91405 Orsay Cedex (France); Basu, Sarbani [Department of Astronomy, Yale University, New Haven, CT 06520-8101 (United States); Creevey, Orlagh L. [Departamento de Astrofisica, Universidad de La Laguna, E-38206 La Laguna, Tenerife (Spain); Gilliland, Ronald L. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Quirion, Pierre-Olivier [Canadian Space Agency, 6767 Boulevard de l' Aeroport, Saint-Hubert, QC, J3Y 8Y9 (Canada); Stello, Denis [Sydney Institute for Astronomy (SIfA), School of Physics, University of Sydney, NSW 2006 (Australia); Kjeldsen, Hans; Christensen-Dalsgaard, Joergen [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Garcia, Rafael A. [Laboratoire AIM, CEA/DSM-CNRS-Universite Paris Diderot-IRFU/SAp, 91191 Gif-sur-Yvette Cedex (France); and others

2012-02-20

We present Kepler observations of the bright (V = 8.3), oscillating star HD 179070. The observations show transit-like events which reveal that the star is orbited every 2.8 days by a small, 1.6 R{sub Earth} object. Seismic studies of HD 179070 using short cadence Kepler observations show that HD 179070 has a frequency-power spectrum consistent with solar-like oscillations that are acoustic p-modes. Asteroseismic analysis provides robust values for the mass and radius of HD 179070, 1.34 {+-} 0.06 M{sub Sun} and 1.86 {+-} 0.04 R{sub Sun }, respectively, as well as yielding an age of 2.84 {+-} 0.34 Gyr for this F5 subgiant. Together with ground-based follow-up observations, analysis of the Kepler light curves and image data, and blend scenario models, we conservatively show at the >99.7% confidence level (3{sigma}) that the transit event is caused by a 1.64 {+-} 0.04 R{sub Earth} exoplanet in a 2.785755 {+-} 0.000032 day orbit. The exoplanet is only 0.04 AU away from the star and our spectroscopic observations provide an upper limit to its mass of {approx}10 M{sub Earth} (2{sigma}). HD 179070 is the brightest exoplanet host star yet discovered by Kepler.

Spectral analysis of the He-enriched sdO-star HD 127493

Science.gov (United States)

Dorsch, Matti; Latour, Marilyn; Heber, Ulrich

2018-02-01

The bright sdO star HD127493 is known to be of mixed H/He composition and excellent archival spectra covering both optical and ultraviolet ranges are available. UV spectra play a key role as they give access to many chemical species that do not show spectral lines in the optical, such as iron and nickel. This encouraged the quantitative spectral analysis of this prototypical mixed H/He composition sdO star. We determined atmospheric parameters for HD127493 in addition to the abundance of C, N, O, Si, S, Fe, and Ni in the atmosphere using non-LTE model atmospheres calculated with TLUSTY/SYNSPEC. A comparison between the parallax distance measured by Hipparcos and the derived spectroscopic distance indicate that the derived atmospheric parameters are realistic. From our metal abundance analysis, we find a strong CNO signature and enrichment in iron and nickel.

High Protein Diet and Huntington's Disease

Science.gov (United States)

Wu, Yih-Ru; Chen, Pei; Tsai, Fuu-Jen; Yang, Chueh-Lien; Tsao, Ya-Tzu; Chang, Wen; Hsieh, I-Shan; Chern, Yijuang; Soong, Bing-Wen

2015-01-01

Huntington’s disease (HD) is a neurodegenerative disorder caused by the huntingtin (HTT) gene with expanded CAG repeats. In addition to the apparent brain abnormalities, impairments also occur in peripheral tissues. We previously reported that mutant Huntingtin (mHTT) exists in the liver and causes urea cycle deficiency. A low protein diet (17%) restores urea cycle activity and ameliorates symptoms in HD model mice. It remains unknown whether the dietary protein content should be monitored closely in HD patients because the normal protein consumption is lower in humans (~15% of total calories) than in mice (~22%). We assessed whether dietary protein content affects the urea cycle in HD patients. Thirty HD patients were hospitalized and received a standard protein diet (13.7% protein) for 5 days, followed by a high protein diet (HPD, 26.3% protein) for another 5 days. Urea cycle deficiency was monitored by the blood levels of citrulline and ammonia. HD progression was determined by the Unified Huntington’s Disease Rating Scale (UHDRS). The HPD increased blood citrulline concentration from 15.19 μmol/l to 16.30 μmol/l (p = 0.0378) in HD patients but did not change blood ammonia concentration. A 2-year pilot study of 14 HD patients found no significant correlation between blood citrulline concentration and HD progression. Our results indicated a short period of the HPD did not markedly compromise urea cycle function. Blood citrulline concentration is not a reliable biomarker of HD progression. PMID:25992839

High Protein Diet and Huntington's Disease.

Directory of Open Access Journals (Sweden)

Chiung-Mei Chen

Full Text Available Huntington's disease (HD is a neurodegenerative disorder caused by the huntingtin (HTT gene with expanded CAG repeats. In addition to the apparent brain abnormalities, impairments also occur in peripheral tissues. We previously reported that mutant Huntingtin (mHTT exists in the liver and causes urea cycle deficiency. A low protein diet (17% restores urea cycle activity and ameliorates symptoms in HD model mice. It remains unknown whether the dietary protein content should be monitored closely in HD patients because the normal protein consumption is lower in humans (~15% of total calories than in mice (~22%. We assessed whether dietary protein content affects the urea cycle in HD patients. Thirty HD patients were hospitalized and received a standard protein diet (13.7% protein for 5 days, followed by a high protein diet (HPD, 26.3% protein for another 5 days. Urea cycle deficiency was monitored by the blood levels of citrulline and ammonia. HD progression was determined by the Unified Huntington's Disease Rating Scale (UHDRS. The HPD increased blood citrulline concentration from 15.19 μmol/l to 16.30 μmol/l (p = 0.0378 in HD patients but did not change blood ammonia concentration. A 2-year pilot study of 14 HD patients found no significant correlation between blood citrulline concentration and HD progression. Our results indicated a short period of the HPD did not markedly compromise urea cycle function. Blood citrulline concentration is not a reliable biomarker of HD progression.

Evidence for a connection between photospheric and wind structure in HD 64760

Science.gov (United States)

Kaufer, A.; Prinja, R. K.; Stahl, O.

2002-02-01

We report on the results of an extended optical spectroscopic monitoring campaign on the early-type B supergiant HD 64760 (B0.5 Ib). The study is based on high-resolution echelle spectra obtained with the Landessternwarte Heidelberg's HEROS instrument at ESO La Silla. Ninety-nine spectra were collected over 103 nights between January 19 and May 1, 1996. The Hα line shows a characteristic profile with a central photospheric absorption superimposed by symmetrically blue- and red-shifted wind-emission humps. The time-averaged line profile is well described by a differentially rotating and expanding radiation-driven wind: the redistribution of the wind emission flux into a double peak profile is interpreted in terms of the resonance zone effect in rotating winds as first described by Petrenz & Puls (\\cite{Pet96}). Detailed time-series analyses of the line profile variations across the Hα profile reveal for the first time in an optical data set of HD 64760 a periodic 2.4-day modulation of the inner and outer flanks of the Hα emission humps. The stronger modulations of the inner flanks of the emission humps at photospheric velocities are due to complex width variations of the underlying photospheric Hα profile. The weaker variations of the outer flanks are in phase and reflect variations at the base of the stellar wind. The detected 2.4-day modulation period together with a second period of 1.2 days (in the red emission hump only) is in excellent agreement with the outer-wind modulation periods as reported by Fullerton et al. (\\cite{Ful97}) from intensive IUE UV time-series observations in 1993 and 1995. The 2.4-day period is further detected in the photospheric He I lambda4026 line as prograde traveling (pseudo-)absorption and emission features. The observed variability pattern is indicative for low-order non-radial pulsations in the photosphere of HD 64760. The non-radial pulsations are identified as the source of persistent, regularly spaced stellar surface

SU-F-T-629: Effect of Multi-Leaf Collimator (MLC) Width On Plan Quality of Single-Isocenter VMAT Intracranial Stereotactic Radiosurgery for Multiple Metastases

International Nuclear Information System (INIS)

Kraus, J; Thomas, E; Wu, X; Fiveash, J; Popple, R

2016-01-01

Purpose: Single-isocenter VMAT has been shown able to create high quality plans for complex intracranial multiple metastasis SRS cases. Linacs capable of the technique are typically outfitted with an MLC that consists of a combination of 5 mm and 10 mm leaves (standard) or 2.5 mm and 5 mm leaves (high-definition). In this study, we test the hypothesis that thinner collimator leaves are associated with improved plan quality. Methods: Ten multiple metastasis cases were identified and planned for VMAT SRS using a 10 MV flattening filter free beam. Plans were created for a standard (std) and a high-definition (HD) MLC. Published values for leaf transmission factor and dosimetric leaf gap were utilized. All other parameters were invariant. Conformity (plan and individual target), moderate isodose spill (V50%), and low isodose spill (mean brain dose) were selected for analysis. Results: Compared to standard MLC, HD-MLC improved overall plan conformity (median: Paddick CI-HD = 0.83, Paddick CI-std = 0.79; p = 0.004 and median: RTOG CI-HD =1.18, RTOG CI-std =1.24; p = 0.01 ), improved individual lesion conformity (median: Paddick CI-HD,i =0.77, Paddick CI-std,i =0.72; p < 0.001 and median: RTOG CI-HD,i = 1.28, RTOG CI-std,i =1.35; p < 0.001), improved moderate isodose spill (median: V50%-HD = 37.0 cc, V50%-std = 45.7 cc; p = 0.002), and improved low dose spill (median: dmean-HD = 2.90 Gy, dmean-std = 3.19 Gy; p = 0.002). Conclusion: For the single-isocenter VMAT SRS of multiple metastasis plans examined, use of HD-MLC modestly improved conformity, moderate isodose, and low isodose spill compared to standard MLC. However, in all cases we were able to generate clinically acceptable plans with the standard MLC. More work is need to further quantify the difference in cases with higher numbers of small targets and to better understand any potential clinical significance. This research was supported in part by Varian Medical Systems.

SU-F-T-629: Effect of Multi-Leaf Collimator (MLC) Width On Plan Quality of Single-Isocenter VMAT Intracranial Stereotactic Radiosurgery for Multiple Metastases

Energy Technology Data Exchange (ETDEWEB)

Kraus, J; Thomas, E; Wu, X; Fiveash, J; Popple, R [University Alabama Birmingham, Birmingham, AL (United States)

2016-06-15

Purpose: Single-isocenter VMAT has been shown able to create high quality plans for complex intracranial multiple metastasis SRS cases. Linacs capable of the technique are typically outfitted with an MLC that consists of a combination of 5 mm and 10 mm leaves (standard) or 2.5 mm and 5 mm leaves (high-definition). In this study, we test the hypothesis that thinner collimator leaves are associated with improved plan quality. Methods: Ten multiple metastasis cases were identified and planned for VMAT SRS using a 10 MV flattening filter free beam. Plans were created for a standard (std) and a high-definition (HD) MLC. Published values for leaf transmission factor and dosimetric leaf gap were utilized. All other parameters were invariant. Conformity (plan and individual target), moderate isodose spill (V50%), and low isodose spill (mean brain dose) were selected for analysis. Results: Compared to standard MLC, HD-MLC improved overall plan conformity (median: Paddick CI-HD = 0.83, Paddick CI-std = 0.79; p = 0.004 and median: RTOG CI-HD =1.18, RTOG CI-std =1.24; p = 0.01 ), improved individual lesion conformity (median: Paddick CI-HD,i =0.77, Paddick CI-std,i =0.72; p < 0.001 and median: RTOG CI-HD,i = 1.28, RTOG CI-std,i =1.35; p < 0.001), improved moderate isodose spill (median: V50%-HD = 37.0 cc, V50%-std = 45.7 cc; p = 0.002), and improved low dose spill (median: dmean-HD = 2.90 Gy, dmean-std = 3.19 Gy; p = 0.002). Conclusion: For the single-isocenter VMAT SRS of multiple metastasis plans examined, use of HD-MLC modestly improved conformity, moderate isodose, and low isodose spill compared to standard MLC. However, in all cases we were able to generate clinically acceptable plans with the standard MLC. More work is need to further quantify the difference in cases with higher numbers of small targets and to better understand any potential clinical significance. This research was supported in part by Varian Medical Systems.

Upregulated GABA inhibitory function in AD/HD children with Child Behavior Checklist–Dysregulation Profile: 123I-iomazenil SPECT study

Directory of Open Access Journals (Sweden)

Shinichiro eNagamitsu

2015-06-01

Full Text Available The Child Behavior Checklist–Dysregulation Profile (CBCL-DP refers to a pattern of elevated scores on the Attention Problems, Aggression, and Anxiety/Depression subscales of the Child Behavior Checklist. The aim of the present study was to investigate the potential role of GABA inhibitory neurons in children with attention deficit/hyperactivity disorder (AD/HD and dysregulation assessed with a dimensional measure. Brain single photon emission computed tomography (SPECT was performed in 35 children with AD/HD using 123I-iomazenil, which binds with high affinity to benzodiazepine receptors. Iomazenil binding activities were assessed with respect to the presence or absence of a threshold CBCL-DP (a score ≥210 for the sum of the three subscales Attention Problems, Aggression, and Anxiety/Depression. We then attempted to identify which CBCL-DP subscale explained the most variance with respect to SPECT data, using age, sex, and history of maltreatment as covariates. Significantly higher iomazenil binding activity was seen in the posterior cingulate cortex (PCC of AD/HD children with a significant CBCL-DP. The Anxiety/Depression subscale on the CBCL had significant effects on higher iomazenil binding activity in the left superior frontal, middle frontal, and temporal regions, as well as in the PCC. The present brain SPECT findings suggest that GABAergic inhibitory neurons may play an important role in the neurobiology of the CBCL-DP, in children with ADHD.

New analysis indicates no thermal inversion in the atmosphere of HD 209458b

International Nuclear Information System (INIS)

Diamond-Lowe, Hannah; Stevenson, Kevin B.; Bean, Jacob L.; Line, Michael R.; Fortney, Jonathan J.

2014-01-01

An important focus of exoplanet research is the determination of the atmospheric temperature structure of strongly irradiated gas giant planets, or hot Jupiters. HD 209458b is the prototypical exoplanet for atmospheric thermal inversions, but this assertion does not take into account recently obtained data or newer data reduction techniques. We reexamine this claim by investigating all publicly available Spitzer Space Telescope secondary-eclipse photometric data of HD 209458b and performing a self-consistent analysis. We employ data reduction techniques that minimize stellar centroid variations, apply sophisticated models to known Spitzer systematics, and account for time-correlated noise in the data. We derive new secondary-eclipse depths of 0.119% ± 0.007%, 0.123% ± 0.006%, 0.134% ± 0.035%, and 0.215% ± 0.008% in the 3.6, 4.5, 5.8, and 8.0 μm bandpasses, respectively. We feed these results into a Bayesian atmospheric retrieval analysis and determine that it is unnecessary to invoke a thermal inversion to explain our secondary-eclipse depths. The data are well fitted by a temperature model that decreases monotonically between pressure levels of 1 and 0.01 bars. We conclude that there is no evidence for a thermal inversion in the atmosphere of HD 209458b.

Gonadal function and fertility in survivors after Hodgkin lymphoma treatment within the German Hodgkin Study Group HD13 to HD15 trials.

Science.gov (United States)

Behringer, Karolin; Mueller, Horst; Goergen, Helen; Thielen, Indra; Eibl, Angelika Diana; Stumpf, Volker; Wessels, Carsten; Wiehlpütz, Martin; Rosenbrock, Johannes; Halbsguth, Teresa; Reiners, Katrin S; Schober, Thomas; Renno, Jorg H; von Wolff, Michael; van der Ven, Katrin; Kuehr, Marietta; Fuchs, Michael; Diehl, Volker; Engert, Andreas; Borchmann, Peter

2013-01-10

To optimize fertility advice in patients with Hodgkin lymphoma (HL) before therapy and during survivorship, information on the impact of chemotherapy is needed. Therefore, we analyzed gonadal functions in survivors of HL. Women younger than age 40 and men younger than 50 years at diagnosis in ongoing remission at least 1 year after therapy within the German Hodgkin Study Group HD13 to HD15 trials for early- and advanced-stage HL were included. Hormone parameters, menstrual cycle, symptoms of hypogonadism, and offspring were evaluated. A total of 1,323 (55%) of 2,412 contacted female and male survivors were evaluable for the current analysis (mean follow-up, 46 and 48 months, respectively). Follicle-stimulating hormone, anti-Müllerian hormone, and inhibin B levels correlated significantly with therapy intensity (P years: 82% v 45%, respectively; P years suffered severe menopausal symptoms (three- to four-fold more frequently than expected). In contrast, male survivors had mean levels of testosterone within the normal range and reported no increased symptoms of hypogonadism. The present analysis in a large group of survivors of HL provides well-grounded information on gonadal toxicity of currently used treatment regimens and allows risk-adapted fertility preservation and comprehensive support during therapy and follow-up.

Integrated Structural Health Sensors for Inflatable Space Habitats, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Luna proposes to continue development of integrated high-definition fiber optic sensors (HD-FOS) and carbon nanotube (CNT)-graphene piezoresistive sensors for...

A genome-wide survey of homeodomain-leucine zipper genes and analysis of cold-responsive HD-Zip I members' expression in tomato.

Science.gov (United States)

Zhang, Zhenzhu; Chen, Xiuling; Guan, Xin; Liu, Yang; Chen, Hongyu; Wang, Tingting; Mouekouba, Liana Dalcantara Ongouya; Li, Jingfu; Wang, Aoxue

2014-01-01

Homeodomain-leucine zipper (HD-Zip) proteins are a kind of transcriptional factors that play a vital role in plant growth and development. However, no detailed information of HD-Zip family in tomato has been reported till now. In this study, 51 HD-Zip genes (SlHZ01-51) in this family were identified and categorized into 4 classes by exon-intron and protein structure in tomato (Solanum lycopersicum) genome. The synthetical phylogenetic tree of tomato, Arabidopsis and rice HD-Zip genes were established for an insight into their evolutionary relationships and putative functions. The results showed that the contribution of segmental duplication was larger than that of tandem duplication for expansion and evolution of genes in this family of tomato. The expression profile results under abiotic stress suggested that all SlHZ I genes were responsive to cold stress. This study will provide a clue for the further investigation of functional identification and the role of tomato HD-Zip I subfamily in plant cold stress responses and developmental events.

"Osiris"(HD209458b), an evaporating planet

OpenAIRE

Vidal-Madjar, Alfred; Etangs, Alain Lecavelier des

2003-01-01

Three transits of the planet orbiting the solar type star HD209458 were observed in the far UV at the wavelength of the HI Ly-alpha line. The planet size at this wavelength is equal to 4.3 R_Jup, i.e. larger than the planet Roche radius (3.6 R_Jup). Absorbing hydrogen atoms were found to be blueshifted by up to -130 km/s, exceeding the planet escape velocity. This implies that hydrogen atoms are escaping this ``hot Jupiter'' planet. An escape flux of >~ 10^10g/s is needed to explain the obser...

NEW PRECISION ORBITS OF BRIGHT DOUBLE-LINED SPECTROSCOPIC BINARIES. V. THE AM STARS HD 434 AND 41 SEXTANTIS

International Nuclear Information System (INIS)

Fekel, Francis C.; Williamson, Michael H.

2010-01-01

We have detected the secondary component in two previously known spectroscopic binaries, HD 434 and 41 Sex, and for the first time determined double-lined orbits for them. Despite the relatively long period of 34.26 days and a moderate eccentricity of 0.32, combined with the components' rotationally broadened lines, measurement of the primary and secondary radial velocities of HD 434 has enabled us to obtain significantly improved orbital elements. While the 41 Sex system has a much shorter period of 6.167 days and a circular orbit, the estimated V mag difference of 3.2 between its components also makes this a challenging system. The new orbital dimensions (a 1 sin i and a 2 sin i) and minimum masses (m 1 sin 3 i and m 2 sin 3 i) of HD 434 have accuracies of 0.8% or better, while the same quantities for 41 Sex are good to 0.5% or better. Both components of HD 434 are Am stars while the Am star primary of 41 Sex has a late-F or early-G companion. All four stars are on the main sequence. The two components of HD 434 are rotating much faster than their predicted pseudosynchronous velocities, while both components of 41 Sex are synchronously rotating. For the primary of 41 Sex, the spectrum line depth changes noted by Sreedhar Rao et al. were not detected.

HD domain of SAMHD1 influences Vpx-induced degradation at a post-interaction step

Energy Technology Data Exchange (ETDEWEB)

Kang, Jian; Hou, Jingwei; Zhao, Ke; Yu, Xiao-Fang; Du, Juan, E-mail: jdu@jlu.edu.cn

2016-02-12

Primate SAMHD1 proteins are potent inhibitors of viruses, including retroviruses such as HIV-1, HIV-2, and SIV. Vpx, a distinctive viral protein expressed by HIV-2 and some SIVs, induces SAMHD1 degradation by forming a Vpx-DCAF1-based ubiquitin ligase complex. Either the N- or the C-terminus of SAMHD1 is critical for Vpx-induced degradation, depending on the types of SAMHD1 and Vpx proteins. However, it was not fully understood whether other regions of SAMHD1 also contribute to its depletion by Vpx. In the present study, we report that SAMHD1 from chicken (SAMHD1{sub GG}) was not degraded by SIVmac Vpx, in contrast with results for human SAMHD1 (SAMHD1{sub HS}). Results regarding to SAMHD1{sub HS} and SAMHD1{sub GG} fusion proteins supported previous findings that the C-terminus of SAMHD1{sub HS} is essential for Vpx-induced degradation. Internal domain substitution, however, revealed that the HD domain also contributes to Vpx-mediated SAMHD1 degradation. Interestingly, the HD domain influenced Vpx-mediated SAMHD1 degradation without affecting Vpx-SAMHD1 interaction. Therefore, our findings revealed that factors in addition to Vpx-SAMHD1 binding influence the efficiency of Vpx-mediated SAMHD1 degradation. - Highlights: • SAMHD1{sub GG} from chicken could not be depleted by SIVmac Vpx. • The C-terminus of human SAMHD1{sub HS} is critical for its degradation by Vpx. • The HD domain is essential for Vpx-induced degradation of SAMHD1{sub HS}. • Altering the HD domain does not affect Vpx-SAMHD1 interaction.

High definition endoscopy with or without I-Scan increases the detection of celiac disease during routine endoscopy.

Science.gov (United States)

Penny, Hugo A; Mooney, Peter D; Burden, Mitchell; Patel, Nisha; Johnston, Alexander J; Wong, Simon H; Teare, Julian; Sanders, David S

2016-06-01

Celiac disease remains underdiagnosed at endoscopy. We aimed to assess the utility of I-Scan (virtual chromo-endoscopy) to improve sensitivity of endoscopy to detect markers of villous atrophy in this condition. Patients from 2 UK hospitals were studied in 3 groups. Group 1: standard high definition, white light endoscopy (WLE); Group 2: WLE plus I-Scan; Group 3: non-high definition control group. The presence of endoscopic markers was recorded. At least 4 duodenal biopsies were taken from all patients. Serology was performed concurrently and observations were compared with histology. 758 patients (62% female, mean age 52) were recruited (Group 1: 230; Group 2: 228; Group 3: 300). 135 (17.8%) new diagnoses of coeliac disease were made (21 Group 1; 24 Group 2; 89 Group 3). The sensitivity for detection of endoscopic markers of villous atrophy was significantly higher in both Group 1 (85.7%, p=0.0004) and Group 2 (75%, p=0.005) compared to non-high definition controls (41.6%). There was no significant difference between high definition only and I-Scan groups (p=0.47). In non-high definition endoscopy a missed diagnosis was associated with lesser degrees of villous atrophy (p=0.019) and low tTG titre (p=0.007). High definition endoscopy with or without I-Scan increases the detection of celiac disease during routine endoscopy. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Interstellar gas and large grains toward HD 38087

International Nuclear Information System (INIS)

Snow, T.P.; Witt, A.

1989-01-01

High-dispersion IUE spectra have been obtained of HD 38087, a star associated with reflection nebulosity where 2175 A scattering has previously been observed. The presence of 2175 A in emission implies unusually large grains, an attempt was made to see how these unusual grains may have affected the depletions of gas-phase elements onto dust in the line of sight. Even though the observed scattering region constitutes only a fraction of the total column density of dust, it is expected that the present line-of-sight analysis provides useful information on the gas and dust in the scattering nebulosity. Somewhat larger overall depletions than normal are found, and it is found that the depletions of certain elements (manganese and zinc) are enhanced relative to the normal pattern of element-to-element depletions, suggesting that grain growth has occurred with some elements sticking to grains preferentially. The molecular fraction in the line of sight is low, in accord with similar lines of sight having low far-ultraviolet extinction and large depletions. 37 refs

HD 169142 in the eyes of ZIMPOL/SPHERE

Science.gov (United States)

Bertrang, G. H.-M.; Avenhaus, H.; Casassus, S.; Montesinos, M.; Kirchschlager, F.; Perez, S.; Cieza, L.; Wolf, S.

2018-03-01

We present new data of the protoplanetary disc surrounding the Herbig Ae/Be star HD 169142 obtained in the very broad-band (VBB) with the Zurich imaging polarimeter (ZIMPOL), a subsystem of the Spectro-Polarimetric High-contrast Exoplanet REsearch instrument (SPHERE) at the Very Large Telescope (VLT). Our Polarimetric Differential Imaging (PDI) observations probe the disc as close as 0.03 arcsec (3.5 au) to the star and are able to trace the disc out to ˜1.08 arcsec (˜126 au). We find an inner hole, a bright ring bearing substructures around 0.18 arcsec (21 au), and an elliptically shaped gap stretching from 0.25 to 0.47 arcsec (29-55 au). Outside of 0.47 arcsec, the surface brightness drops off, discontinued only by a narrow annular brightness minimum at ˜0.63 to 0.74 arcsec (74-87 au). These observations confirm features found in less-well-resolved data as well as reveal yet undetected indications for planet-disc interactions, such as small-scale structures, star-disc offsets, and potentially moving shadows.

A MULTIPLE SCATTERING POLARIZED RADIATIVE TRANSFER MODEL: APPLICATION TO HD 189733b

Energy Technology Data Exchange (ETDEWEB)

Kopparla, Pushkar; Yung, Yuk L. [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA (United States); Natraj, Vijay; Swain, Mark R. [Jet Propulsion Laboratory (NASA-JPL), Pasadena, CA (United States); Zhang, Xi [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ (United States); Wiktorowicz, Sloane J., E-mail: pkk@gps.caltech.edu [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA (United States)

2016-01-20

We present a multiple scattering vector radiative transfer model that produces disk integrated, full phase polarized light curves for reflected light from an exoplanetary atmosphere. We validate our model against results from published analytical and computational models and discuss a small number of cases relevant to the existing and possible near-future observations of the exoplanet HD 189733b. HD 189733b is arguably the most well observed exoplanet to date and the only exoplanet to be observed in polarized light, yet it is debated if the planet’s atmosphere is cloudy or clear. We model reflected light from clear atmospheres with Rayleigh scattering, and cloudy or hazy atmospheres with Mie and fractal aggregate particles. We show that clear and cloudy atmospheres have large differences in polarized light as compared to simple flux measurements, though existing observations are insufficient to make this distinction. Futhermore, we show that atmospheres that are spatially inhomogeneous, such as being partially covered by clouds or hazes, exhibit larger contrasts in polarized light when compared to clear atmospheres. This effect can potentially be used to identify patchy clouds in exoplanets. Given a set of full phase polarimetric measurements, this model can constrain the geometric albedo, properties of scattering particles in the atmosphere, and the longitude of the ascending node of the orbit. The model is used to interpret new polarimetric observations of HD 189733b in a companion paper.

Application of an Arbitrary Lagrangian Eulerian Method to Describe High Velocity Gas-Particle Flow Behavior

Science.gov (United States)

2011-09-01

applied in this work was based on some of the standard definitions of soil constitutive properties as found in, e.g., Chen and Baladi [20], and...Livermore, CA. [20] Chen, W. F., and Baladi , G. Y., 1985. Soil Plasticity: Theory and Implementation. Elsevier Science, New York. [21] Zimmerman, H.D

Quantum Dynamics Study of the Isotopic Effect on Capture Reactions: HD, D2 + CH3

Science.gov (United States)

Wang, Dunyou; Kwak, Dochan (Technical Monitor)

2002-01-01

Time-dependent wave-packet-propagation calculations are reported for the isotopic reactions, HD + CH3 and D2 + CH3, in six degrees of freedom and for zero total angular momentum. Initial state selected reaction probabilities for different initial rotational-vibrational states are presented in this study. This study shows that excitations of the HD(D2) enhances the reactivities; whereas the excitations of the CH3 umbrella mode have the opposite effects. This is consistent with the reaction of H2 + CH3. The comparison of these three isotopic reactions also shows the isotopic effects in the initial-state-selected reaction probabilities. The cumulative reaction probabilities (CRP) are obtained by summing over initial-state-selected reaction probabilities. The energy-shift approximation to account for the contribution of degrees of freedom missing in the six dimensionality calculation is employed to obtain approximate full-dimensional CRPs. The rate constant comparison shows H2 + CH3 reaction has the biggest reactivity, then HD + CH3, and D2 + CH3 has the smallest.

PpHB22, a member of HD-Zip proteins, activates PpDAM1 to regulate bud dormancy transition in 'Suli' pear (Pyrus pyrifolia White Pear Group).

Science.gov (United States)

Yang, Qinsong; Niu, Qingfeng; Li, Jianzhao; Zheng, Xiaoyan; Ma, Yunjing; Bai, Songling; Teng, Yuanwen

2018-06-01

Homeodomain-leucine zipper (HD-Zip) proteins, which form one of the largest and most diverse families, regulate many biological processes in plants, including differentiation, flowering, vascular development, and stress signaling. Abscisic acid (ABA) has been proved to be one of the key regulators of bud dormancy and to influence several HD-Zip genes expression. However, the role of HD-Zip genes in regulating bud dormancy remains unclear. We identified 47 pear (P. pyrifolia White Pear Group) HD-Zip genes, which were classified into four subfamilies (HD-Zip I-IV). We further revealed that gene expression levels of some HD-Zip members were closely related to ABA concentrations in flower buds during dormancy transition. Exogenous ABA treatment confirmed that PpHB22 and several other HD-Zip genes responded to ABA. Yeast one-hybrid and dual luciferase assay results combining subcellular localization showed that PpHB22 was present in nucleus and directly induced PpDAM1 (dormancy associated MADS-box 1) expression. Thus, PpHB22 is a negative regulator of plant growth associated with the ABA response pathway and functions upstream of PpDAM1. These findings enrich our understanding of the function of HD-Zip genes related to the bud dormancy transition. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

The Case of the Tail Wagging the Dog: HD 189733 - Evidence of Hot Jupiter Exoplanets Spinning-up Their Host Stars

Science.gov (United States)

Guinan, E. F.

2013-06-01

(Abstract only) HD 189733A is an eighth mag K1.5V star that has attracted much attention because it hosts a short period, transiting, hot-Jupiter planet. This planet, HD 189733b, has one of the shortest known orbital periods (P = 2.22 days) and is only 0.031 AU from its host star. Because the system undergoes eclipses and is bright, HD 189733 has been extensively studied. The planet's atmosphere has been found to contain water vapor, methane, CO2, and sodium and possible haze. Spitzer IR observations indicate planet temperature, varying ~970 K to ~1,200 K over its surface (Tinetti (2007). Based on measurements of the K-star's P(rot) from starspot modulations of ~11.95 d, strong coronal X-ray emission and chromospheric Ca II-HK emission indicate a young age of ~0.7 Gyr. But this apparent young age is discrepant with a much older age (> 4 Gyr) inferred from the star's very low Lithium abundance. However, the age of the HD 189733 system can be independently determined by the presence of a faint dM4 companion (HD 189733B) some 12" away. Our Age-Activity relations for this star (no detectable coronal X-ray emission and no H-alpha emission) indicate an age > 4 Gyr (and < 8 Gyr from kinematics and metallicity). This age should apply to its K star companion and its planet. The fast rotation and resultant high activity levels of the K star can best be explained from the increase in its (rotation) angular momentum (AM) from the orbital AM of the planet. This AM transfer occurs from tidal and magnetic interactions of the K star with its planet. Determining the possible decrease in the planet's orbital period is possible from studying the planet eclipse times (which can be done by AAVSO members with CCD photometry). We also discuss the properties of other related short-period exoplanet systems found by the Kepler Mission that show similar behavior - in that close-in hot Jupiter size planets appear to be physically interacting with their host stars. This work is supported by

GRANULATION SIGNATURES IN THE SPECTRUM OF THE VERY METAL-POOR RED GIANT HD 122563

International Nuclear Information System (INIS)

RamIrez, I.; Collet, R.; Asplund, M.; Lambert, D. L.; Allende Prieto, C.

2010-01-01

A very high resolution (R = λ/Δλ = 200, 000), high signal-to-noise ratio (S/N ≅ 340) blue-green spectrum of the very metal-poor ([Fe/H] ≅ -2.6) red giant star HD 122563 has been obtained by us at McDonald Observatory. We measure the asymmetries and core wavelengths of a set of unblended Fe I lines covering a wide range of line strength. Line bisectors exhibit the characteristic C-shape signature of surface convection (granulation) and they span from about 100 m s -1 in the strongest Fe I features to 800 m s -1 in the weakest ones. Core wavelength shifts range from about -100 to -900 m s -1 , depending on line strength. In general, larger blueshifts are observed in weaker lines, but there is increasing scatter with increasing residual flux. Assuming local thermodynamic equilibrium (LTE), we synthesize the same set of spectral lines using a state-of-the-art three-dimensional (3D) hydrodynamic simulation for a stellar atmosphere of fundamental parameters similar to those of HD 122563. We find good agreement between model predictions and observations. This allows us to infer an absolute zero point for the line shifts and radial velocity. Moreover, it indicates that the structure and dynamics of the simulation are realistic, thus providing support to previous claims of large 3D-LTE corrections to elemental abundances and fundamental parameters of very metal-poor red giant stars obtained with standard 1D-LTE spectroscopic analyses, as suggested by the hydrodynamic model used here.

Exocometary gas in the HD 181327 debris ring

OpenAIRE

Marino, S; Matrà, L; Stark, C; Wyatt, MC; Casassus, S; Kennedy, G; Rodriguez, D; Zuckerman, B; Perez, S; Dent, WRF; Kuchner, M; Hughes, AM; Schneider, G; Steele, A; Roberge, A

2016-01-01

An increasing number of observations have shown that gaseous debris discs are not an exception. However, until now, we only knew of cases around A stars. Here we present the first detection of 12CO (2-1) disc emission around an F star, HD 181327, obtained with the Atacama Large Millimeter/submillimeter Array (ALMA) observations at 1.3 mm. The continuum and CO emission are resolved into an axisymmetric disc with ring-like morphology. Using a Markov chain Monte Carlo method coupled with radiati...

Dosimetric validation of Monaco treatment planning system on an Elekta VersaHD linear accelerator.

Science.gov (United States)

Narayanasamy, Ganesh; Saenz, Daniel L; Defoor, Dewayne; Papanikolaou, Niko; Stathakis, Sotirios

2017-11-01

The purpose of this study is to perform dosimetric validation of Monaco treatment planning system version 5.1. The Elekta VersaHD linear accelerator with high dose rate flattening filter-free photon modes and electron energies was used in this study. The dosimetric output of the new Agility head combined with the FFF photon modes warranted this investigation into the dosimetric accuracy prior to clinical usage. A model of the VersaHD linac was created in Monaco TPS by Elekta using commissioned beam data including percent depth dose curves, beam profiles, and output factors. A variety of 3D conformal fields were created in Monaco TPS on a combined Plastic water/Styrofoam phantom and validated against measurements with a calibrated ion chamber. Some of the parameters varied including source to surface distance, field size, wedges, gantry angle, and depth for all photon and electron energies. In addition, a series of step and shoot IMRT, VMAT test plans, and patient plans on various anatomical sites were verified against measurements on a Delta 4 diode array. The agreement in point dose measurements was within 2% for all photon and electron energies in the homogeneous phantom and within 3% for photon energies in the heterogeneous phantom. The mean ± SD gamma passing rates of IMRT test fields yielded 93.8 ± 4.7% based on 2% dose difference and 2 mm distance-to-agreement criteria. Eight previously treated IMRT patient plans were replanned in Monaco TPS and five measurements on each yielded an average gamma passing rate of 95% with 6.7% confidence limit based on 3%, 3 mm gamma criteria. This investigation on dosimetric validation ensures accuracy of modeling VersaHD linac in Monaco TPS thereby improving patient safety. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

HD 62542: Probing the Bare, Dense Core of an Interstellar Cloud

Science.gov (United States)

Welty, Daniel; Sonnentrucker, Paule G.; Rachford, Brian; Snow, Theodore; York, Donald G.

2018-01-01

We discuss the interstellar absorption from many atomic and molecular species seen in high-resolution HST/STIS UV spectra of the moderately reddened B3-5 V star HD 62542 [E(B-V) ~ 0.35; AV ~ 1.2]. This remarkable sight line exhibits both very steep far-UV extinction and a high fraction of hydrogen in molecular form -- with strong absorption from CH, C2, CN, and CO but weak absorption from CH+ and most of the commonly observed diffuse interstellar bands. Most of the material appears to reside in a single narrow velocity component -- thus offering a rare opportunity to probe the relatively dense, primarily molecular core of a single interstellar cloud, with little associated diffuse atomic gas.Detailed analyses of the absorption-line profiles seen in the UV spectra reveal a number of properties of the main diffuse molecular cloud toward HD 62542:1) The depletions of Mg, Si, and Fe are more severe than those seen in any other sight line, but the depletions of Cl and Kr are very mild; the overall pattern of depletions differs somewhat from those derived from larger samples of Galactic sight lines.2) The rotational excitation of H2 and C2 indicates that the gas is fairly cold (Tk = 40-45 K) and moderately dense (nH > 420 cm-3) somewhat higher densities are suggested by the fine-structure excitation of neutral carbon.3) The excitation temperatures characterizing the rotational populations of both 12CO (11.7 K) and 13CO (7.7 K) are higher than those typically found for Galactic diffuse molecular clouds.4) Carbon is primarily singly ionized -- N(C+) > N(CO) > N(C).5) The relative abundances of various trace neutral atomic species reflect the effects of both the steep far-UV extinction and the severe depletions of some elements.6) Differences in line widths for the various atomic and molecular species are suggestive of differences in spatial distribution within the main cloud.Support for this study was provided by NASA, via STScI grant GO-12277.008-A.

Chemical spots on the surface of the strongly magnetic Herbig Ae star HD 101412

DEFF Research Database (Denmark)

Järvinen, S. P.; Hubrig, S.; Schöller, M.

2016-01-01

Due to the knowledge of the rotation period and the presence of a rather strong surface magnetic field, the sharp-lined young Herbig Ae star HD 101412 with a rotation period of 42 d has become one of the most well-studied targets among the Herbig Ae stars. High-resolution HARPS polarimetric spectra...... that is opposite to the behaviour of the other elements studied. Since classical Ap stars usually show a relationship between the magnetic field geometry and the distribution of element spots, we used in our magnetic field measurements different line samples belonging to the three elements with the most numerous...

HD 193793, a radio-emitting Wolf-Rayet binary star

International Nuclear Information System (INIS)

Florkowski, D.R.; Gottesman, S.T.

1977-01-01

The Wolf-Rayet binary HD 193793 has been observed as a weak, unresolved radio source. The observed flux densities do not agree with the predictions of the constant-mass-flow model of Wright and Barlow and Panagia and Felli. A variable-mass-flow model is suggested and an observational test is proposed. A comparison with γ 2 Vel is made, and the parameters affecting radio emission from Wolf-Rayet stars are briefly discussed. (author)

El medio interestelar alrededor de estrellas Of: HD 108

Science.gov (United States)

Cappa, C.; Testori, J. C.

Hemos analizado la distribución del hidrógeno neutro interestelar en la vecindad de la estrella Of HD 108 en base a perfiles de la línea de 21 cm. Estos datos nos han permitido encontrar una probable burbuja interestelar asociada a la estrella. Comparamos estos resultados con la emisión en otros rangos espectrales y estimamos los principales parámetros físicos de la estructura.

The Transiting Exocomets in the HD 172555 System

Science.gov (United States)

Grady, C. A.; Brown, A.; Kamp, I.; Roberge, A.; Riviere-Marichalar, P.; Welsh, B.

2017-01-01

The Earth is thought to have formed dry, in a part of the Solar Nebula deficient in organic material, and to have acquired its organics and water through bombardment by minor bodies. Observations of this process in well-dated systems can provide insight into the probable origin and composition of the bombarding parent bodies. Transiting cometary activity has previously been reported in Ca II for the late-A member of the 241 Myr old Pictoris Moving Group member, HD 172555(Kiefer et al. 2014). We present HST STIS and COS spectra of HD 172555 demonstrating that the star has chromospheric emission and variable in falling gas features in transitions of silicon and carbon ions at times when no Fe II absorption is seen in the UV data, and no Ca II absorption is seen in contemporary optical spectra. The lack of CO absorption and stable gas absorption at the system velocity is consistent with the absence of a cold Kuiper belt analog (Riviere-Marichalar et al. 2012) in this system. The presence of infall in some species at one epoch and others at different epochs suggests that, like Pictoris, there may be more than one family of exocomets. If perturbed into star-grazing orbits by the same mechanism as for Pic, these data suggest that the wide planet frequency among A-early F stars in the PMG is at least 37.5, well above the frequency estimated for young moving groups independent of host star spectral type.

Molecular marker analysis of heading date Hd1 locus in Egyptian ...

African Journals Online (AJOL)

Nine molecular markers derived from the heading date QTL Hd1 DNA sequence for cultivated rice were used to study the heading date allelic diversity of the cultivated Egyptian rice varieties. The results showed that among the nine simple sequence repeats (SSR) and sequence tagged-sites (STS) markers used, one SSR ...

Electrochemical H-D isotope effect at metal-perovskite proton conductor interfaces

DEFF Research Database (Denmark)

Kek, D.; Bonanos, N.

1999-01-01

The H-D isotope effect on the electrode kinetics of a metal-proton conductor interface has been investigated. The current-voltage behaviour depends on the nature of the electrode (Ni, Ag), the atmosphere (H(2), D(2)), the partial pressures of the gases, and the temperature. The isotope effect was...

A framework for the definition of variants of high-level Petri nets

DEFF Research Database (Denmark)

Kindler, Ekkart; Petrucci, Laure

2009-01-01

with data-type specific issues, which often blocks the view for the really relevant parts. Even worse, supposedly simpler versions of high-level nets often are more difficult to define than high-level nets in general. This paper introduces the concepts and the mathematical tools to ease the definition...

SU-E-I-22: A Comprehensive Investigation of Noise Variations Between the GE Discovery CT750 HD and GE LightSpeed VCT

International Nuclear Information System (INIS)

Bache, S; Loyer, E; Stauduhar, P; Liu, X; Rong, J

2015-01-01

Purpose: To quantify and compare the noise properties between two GE CT models-the Discovery CT750 HD (aka HD750) and LightSpeed VCT, with the overall goal of assessing the impact in clinical diagnostic practice. Methods: Daily QC data from a fleet of 9 CT scanners currently in clinical use were investigated – 5 HD750 and 4 VCT (over 600 total acquisitions for each scanner). A standard GE QC phantom was scanned daily using two sets of scan parameters with each scanner over 1 year. Water CT number and standard deviation were recorded from the image of water section of the QC phantom. The standard GE QC scan parameters (Pitch = 0.516, 120kVp, 0.4s, 335mA, Small Body SFOV, 5mm thickness) and an in-house developed protocol (Axial, 120kVp, 1.0s, 240mA, Head SFOV, 5mm thickness) were used, with Standard reconstruction algorithm. Noise was measured as the standard deviation in the center of the water phantom image. Inter-model noise distributions and tube output in mR/mAs were compared to assess any relative differences in noise properties. Results: With the in-house protocols, average noise for the five HD750 scanners was ∼9% higher than the VCT scanners (5.8 vs 5.3). For the GE QC protocol, average noise with the HD750 scanners was ∼11% higher than with the VCT scanners (4.8 vs 4.3). This discrepancy in noise between the two models was found despite the tube output in mR/mAs being comparable with the HD750 scanners only having ∼4% lower output (8.0 vs 8.3 mR/mAs). Conclusion: Using identical scan protocols, average noise in images from the HD750 group was higher than that from the VCT group. This confirms feedback from an institutional radiologist’s feedback regarding grainier patient images from HD750 scanners. Further investigation is warranted to assess the noise texture and distribution, as well as clinical impact

Neural processing of emotions in traumatized children treated with Eye Movement Desensitization and Reprocessing therapy: A hdEEG study

Directory of Open Access Journals (Sweden)

Cristina eTrentini

2015-11-01

Full Text Available Eye Movement Desensitization and Reprocessing (EMDR therapy has been proven efficacious in restoring affective regulation in Post–Traumatic Stress Disorder (PTSD patients. However, its effectiveness on emotion processing in children with complex trauma has yet to be explored. High density Electroencephalography (hdEEG was used to investigate the effects of EMDR on brain responses to adults’ emotions on children with histories of early maltreatment. Ten school–aged children were examined before (T0 and within one month after the conclusion of EMDR (T1. hdEEGs were recorded while children passively viewed angry, afraid, happy, and neutral faces. Clinical scales were administered at the same time. Correlation analyses were performed to detect brain regions whose activity was linked to children’s traumatic symptom–related and emotional–adaptive problem scores. In all four conditions, hdEEG showed similar significantly higher activity on the right medial prefrontal and fronto–temporal limbic regions at T0, shifting towards the left medial and superior temporal regions at T1. Moreover, significant correlations were found between clinical scales and the same regions whose activity significantly differed between pre– and post–treatment. These preliminary results demonstrate that, after EMDR, children suffering from complex trauma show increased activity in areas implicated in high–order cognitive processing when passively viewing pictures of emotional expressions. These changes are associated with the decrease of depressive and traumatic symptoms, and with the improvement of emotional–adaptive functioning over time.

Slow Histidine H/D Exchange Protocol for Thermodynamic Analysis of Protein Folding and Stability using Mass Spectrometry

OpenAIRE

Tran, Duc T.; Banerjee, Sambuddha; Alayash, Abdu I.; Crumbliss, Alvin L.; Fitzgerald, Michael C.

2012-01-01

Described here is a mass spectrometry based protocol to study the thermodynamic stability of proteins and protein-ligand complexes using the slow H/D exchange reaction of the imidazole C2 proton in histidine side chains. The protocol, which involves evaluating the denaturant dependence of this slow H/D exchange reaction in proteins, allows the global and/or subglobal unfolding/refolding properties of proteins and protein-ligand complexes to be probed. The protocol is developed using several m...

Score of Inattention Subscale of ADHD Rating Scale-IV is Significantly Higher for AD/HD than PDD.

OpenAIRE

Fujibayashi, Hiromi; Kitayama, Shinji; Matsuo, Masafumi

2010-01-01

Attention-deficit/hyperactivity disorder (AD/HD) and pervasive developmental disorder (PDD) must be differentiated because the respective treatments are different. However, they are difficult to distinguish because they often show similar symptoms. At our hospital, we have the rearer of a patient answer both the ADHD Rating Scale-IV (ADHD-RS) and the Autism Spectrum Screening Questionnaire (ASSQ), and use the results as an aid for the diagnosis of AD/HD or PDD. These results were compared wit...

Computation of the Transmitted and Polarized Scattered Fluxes by the Exoplanet HD 189733b in X-Rays

Energy Technology Data Exchange (ETDEWEB)

Marin, Frédéric [Astronomical Institute of the Academy of Sciences, Boční II 1401, CZ-14100 Prague (Czech Republic); Grosso, Nicolas, E-mail: frederic.marin@astro.unistra.fr [Université de Strasbourg, CNRS, Observatoire astronomique de Strasbourg, UMR 7550, F-67000 Strasbourg (France)

2017-02-01

Thousands of exoplanets have been detected, but only one exoplanetary transit was potentially observed in X-rays from HD 189733A. What makes the detection of exoplanets so difficult in this band? To answer this question, we run Monte-Carlo radiative transfer simulations to estimate the amount of X-ray flux reprocessed by HD 189733b. Despite its extended evaporating atmosphere, we find that the X-ray absorption radius of HD 189733b at 0.7 keV, which is the mean energy of the photons detected in the 0.25–2 keV energy band by XMM-Newton , is ∼1.01 times the planetary radius for an atmosphere of atomic hydrogen and helium (including ions), and produces a maximum depth of ∼2.1% at ∼±46 minutes from the center of the planetary transit on the geometrically thick and optically thin corona. We compute numerically in the 0.25–2 keV energy band that this maximum depth is only of ∼1.6% at ∼±47 minutes from the transit center, and not very sensitive to the metal abundance, assuming that adding metals in the atmosphere would not dramatically change the density–temperature profile. Regarding a direct detection of HD 189733b in X-rays, we find that the amount of flux reprocessed by the exoplanetary atmosphere varies with the orbital phase, spanning between three and five orders of magnitude fainter than the flux of the primary star. Additionally, the degree of linear polarization emerging from HD 189733b is <0.003%, with maximums detected near planetary greatest elongations. This implies that both the modulation of the X-ray flux with the orbital phase and the scatter-induced continuum polarization cannot be observed with current X-ray facilities.

The novel kinetics expression of Cadmium (II) removal using green adsorbent horse dung humic acid (Hd-Ha)

Science.gov (United States)

Basuki, Rahmat; Santosa, Sri Juari; Rusdiarso, Bambang

2017-03-01

Humic acid from dry horse dung powder has been prepared and this horse dung humic acid (HD-HA) was then applied as a sorbent to adsorb Cadmium(II) from a solution. Characterization of HD-HA was conducted by detection of its functional group, UV-Vis spectra, ash level, and total acidity. Result of the work showed that HD-HA had similar character compared with peat soil humic acid (PS-HA) and previous researchers. The adsorption study of this work was investigated by batch experiment in pH 5. The thermodynamics parameters in this work were determined by the Langmuir isotherm model for monolayer sorption and Freundlich isotherm model multilayer sorption. Monolayer sorption capacity (b) for HD-HA was 1.329 × 10-3 mol g-1, equilibrium constant (K) was 5.651 (mol/L)-1, and multilayer sorption capacity was 2.646 × 10-2 mol g-1. The kinetics parameters investigated in this work were determined by the novel kinetics expression resulted from the mathematical derivation the availability of binding sites of sorbent. Adsorption rate constant (ka) from this novel expression was 43.178 min-1 (mol/L)-1 and desorption rate constant (kd) was 1.250 × 10-2 min-1. Application of the kinetics model on sorption Cd(II) onto HD-HA showed the nearly all of models gave a good linearity. However, only this proposed kinetics expression has good relation with Langmuir model. The novel kinetics expression proposed in this paper seems to be more realistic and reasonable and close to the experimental real condition because the value of ka/kd (3452 (mol/L)-1) was fairly close with K from Langmuir isotherm model (5651 (mol/L)-1). Comparison of this novel kinetics expression with well-known Lagergren pseudo-first order kinetics and Ho pseudo-second order kinetics was also critically discussed in this paper.

DEBRIS DISTRIBUTION IN HD 95086—A YOUNG ANALOG OF HR 8799

International Nuclear Information System (INIS)

Su, Kate Y. L.; Smith, Paul S.; Rieke, George H.; Morrison, Sarah; Malhotra, Renu; Balog, Zoltan

2015-01-01

HD 95086 is a young early-type star that hosts (1) a 5 M J planet at the projected distance of 56 AU revealed by direct imaging, and (2) a prominent debris disk. Here we report the detection of 69 μm crystalline olivine feature from the disk using the Spitzer/MIPS-SED data covering 55-95 μm. Due to the low resolution of the MIPS-SED mode, this feature is not spectrally resolved, but is consistent with the emission from crystalline forsterite contributing ∼5% of the total dust mass. We also present detailed analysis of the disk spectral energy distribution and re-analysis of resolved images obtained by Herschel. Our results suggest that the debris structure around HD 95086 consists of a warm (∼175 K) belt, a cold (∼55 K) disk, and an extended disk halo (up to ∼800 AU), and is very similar to that of HR 8799. We compare the properties of the three debris components, and suggest that HD 95086 is a young analog of HR 8799. We further investigate and constrain single-planet, two-planet, three-planet, and four-planet architectures that can account for the observed debris structure and are compatible with dynamical stability constraints. We find that equal-mass four-planet configurations of geometrically spaced orbits, with each planet of mass ∼ 5 M J , could maintain the gap between the warm and cold debris belts, and also be just marginally stable for timescales comparable to the age of the system

DEBRIS DISTRIBUTION IN HD 95086—A YOUNG ANALOG OF HR 8799

Energy Technology Data Exchange (ETDEWEB)

Su, Kate Y. L.; Smith, Paul S.; Rieke, George H. [Steward Observatory, University of Arizona, 933 N Cherry Ave., Tucson, AZ 85721 (United States); Morrison, Sarah; Malhotra, Renu [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States); Balog, Zoltan, E-mail: ksu@as.arizona.edu [Max-Planck-Institut für Astronomie, Königstuhl 17 D-69117, Heidelberg (Germany)

2015-02-01

HD 95086 is a young early-type star that hosts (1) a 5 M{sub J} planet at the projected distance of 56 AU revealed by direct imaging, and (2) a prominent debris disk. Here we report the detection of 69 μm crystalline olivine feature from the disk using the Spitzer/MIPS-SED data covering 55-95 μm. Due to the low resolution of the MIPS-SED mode, this feature is not spectrally resolved, but is consistent with the emission from crystalline forsterite contributing ∼5% of the total dust mass. We also present detailed analysis of the disk spectral energy distribution and re-analysis of resolved images obtained by Herschel. Our results suggest that the debris structure around HD 95086 consists of a warm (∼175 K) belt, a cold (∼55 K) disk, and an extended disk halo (up to ∼800 AU), and is very similar to that of HR 8799. We compare the properties of the three debris components, and suggest that HD 95086 is a young analog of HR 8799. We further investigate and constrain single-planet, two-planet, three-planet, and four-planet architectures that can account for the observed debris structure and are compatible with dynamical stability constraints. We find that equal-mass four-planet configurations of geometrically spaced orbits, with each planet of mass ∼ 5 M{sub J} , could maintain the gap between the warm and cold debris belts, and also be just marginally stable for timescales comparable to the age of the system.

HD-MTL: Hierarchical Deep Multi-Task Learning for Large-Scale Visual Recognition.

Science.gov (United States)

Fan, Jianping; Zhao, Tianyi; Kuang, Zhenzhong; Zheng, Yu; Zhang, Ji; Yu, Jun; Peng, Jinye

2017-02-09

In this paper, a hierarchical deep multi-task learning (HD-MTL) algorithm is developed to support large-scale visual recognition (e.g., recognizing thousands or even tens of thousands of atomic object classes automatically). First, multiple sets of multi-level deep features are extracted from different layers of deep convolutional neural networks (deep CNNs), and they are used to achieve more effective accomplishment of the coarseto- fine tasks for hierarchical visual recognition. A visual tree is then learned by assigning the visually-similar atomic object classes with similar learning complexities into the same group, which can provide a good environment for determining the interrelated learning tasks automatically. By leveraging the inter-task relatedness (inter-class similarities) to learn more discriminative group-specific deep representations, our deep multi-task learning algorithm can train more discriminative node classifiers for distinguishing the visually-similar atomic object classes effectively. Our hierarchical deep multi-task learning (HD-MTL) algorithm can integrate two discriminative regularization terms to control the inter-level error propagation effectively, and it can provide an end-to-end approach for jointly learning more representative deep CNNs (for image representation) and more discriminative tree classifier (for large-scale visual recognition) and updating them simultaneously. Our incremental deep learning algorithms can effectively adapt both the deep CNNs and the tree classifier to the new training images and the new object classes. Our experimental results have demonstrated that our HD-MTL algorithm can achieve very competitive results on improving the accuracy rates for large-scale visual recognition.

NEW PRECISION ORBITS OF BRIGHT DOUBLE-LINED SPECTROSCOPIC BINARIES. III. HD 82191, ω DRACONIS, AND 108 HERCULIS

International Nuclear Information System (INIS)

Fekel, Francis C.; Williamson, Michael H.; Tomkin, Jocelyn

2009-01-01

We have determined improved spectroscopic orbits for three double-lined binaries, HD 82191 (Am), ω Dra (F5 V), and 108 Her (Am), using radial velocities from the 2.1 m telescope at McDonald Observatory, the coude feed telescope at Kitt Peak National Observatory, and 2 m telescope at Fairborn Observatory. The orbital periods range from 5.28 to 9.01 days, and all three systems have circular orbits. The new orbital dimensions (a 1 sin i and a 2 sin i) and minimum masses (m 1 sin 3 i and m 2 sin 3 i) have accuracies of 0.2% or better. Our improved results confirm the large minimum masses of HD 82191 and also agree with the values previously found for ω Dra. However, for the components of 108 Her our minimum masses are about 20% larger than the previous best values. We conclude that both components of HD 82191 as well as the primary of 108 Her are Am stars. However, the A9 secondary of 108 Her has normal abundances. We estimate spectral types of F4 dwarf and G0 dwarf for the components of ω Dra. The primaries of the three binaries are synchronously rotating as is the secondary of 108 Her. The secondaries of HD 82191 and ω Dra are possibly synchronously rotating.

VizieR Online Data Catalog: HD20794 HARPS radial velocities (Feng+, 2017)

Science.gov (United States)

Feng, F.; Tuomi, M.; Jones, H. R. A.

2017-05-01

HARPS radial velocities, activity indices and differential radial velocities for HD 20794. The HARPS spectra are available in the European Southern Observatory archive, and are processed using the TERRA algorithm (Anglada-Escude and Butler, 2012, Cat. J/ApJS/200/15). (1 data file).

Comparative evaluation of HD 2D/3D laparoscopic monitors and benchmarking to a theoretically ideal 3D pseudodisplay: even well-experienced laparoscopists perform better with 3D.

Science.gov (United States)

Wilhelm, D; Reiser, S; Kohn, N; Witte, M; Leiner, U; Mühlbach, L; Ruschin, D; Reiner, W; Feussner, H

2014-08-01

Though theoretically superior to standard 2D visualization, 3D video systems have not yet achieved a breakthrough in laparoscopy. The latest 3D monitors, including autostereoscopic displays and high-definition (HD) resolution, are designed to overcome the existing limitations. We performed a randomized study on 48 individuals with different experience levels in laparoscopy. Three different 3D displays (glasses-based 3D monitor, autostereoscopic display, and a mirror-based theoretically ideal 3D display) were compared to a 2D HD display by assessing multiple performance and mental workload parameters and rating the subjects during a laparoscopic suturing task. Electromagnetic tracking provided information on the instruments' pathlength, movement velocity, and economy. The usability, the perception of visual discomfort, and the quality of image transmission of each monitor were subjectively rated. Almost all performance parameters were superior with the conventional glasses-based 3D display compared to the 2D display and the autostereoscopic display, but were often significantly exceeded by the mirror-based 3D display. Subjects performed a task faster and with greater precision when visualization was achieved with the 3D and the mirror-based display. Instrument pathlength was shortened by improved depth perception. Workload parameters (NASA TLX) did not show significant differences. Test persons complained of impaired vision while using the autostereoscopic monitor. The 3D and 2D displays were rated user-friendly and applicable in daily work. Experienced and inexperienced laparoscopists profited equally from using a 3D display, with an improvement in task performance about 20%. Novel 3D displays improve laparoscopic interventions as a result of faster performance and higher precision without causing a higher mental workload. Therefore, they have the potential to significantly impact the further development of minimally invasive surgery. However, as shown by the

Recombinant Bacillus thuringiensis subsp. kurstaki HD73 strain that synthesizes Cry1Ac and chimeric ChiA74∆sp chitinase inclusions.

Science.gov (United States)

González-Ponce, Karen S; Casados-Vázquez, Luz E; Salcedo-Hernández, Rubén; Bideshi, Dennis K; Del Rincón-Castro, María C; Barboza-Corona, José E

2017-05-01

In this study, the endochitinase chiA74 gene lacking its secretion signal peptide sequence (chiA74∆sp) was fused in frame with the sequence coding for the C-terminal crystallization domain and transcription terminator of cry1Ac. The chimeric gene was expressed under the strong pcytA-p/STAB-SD promoter system in an acrystalliferous Cry - B strain of Bacillus thuringiensis and B. thuringiensis subsp. kurstaki HD73. We showed that the chimeric ChiA74∆sp produced amorphous inclusions in both Cry - B and HD73. In addition to the amorphous inclusions putatively composed of the chimera, bipyramidal Cry1Ac crystals, smaller than the wild-type crystal, were observed in recombinant HD73, and chitinase activity was remarkably higher (75-fold) in this strain when compared with parental HD73. Moreover, we observed that lyophilized samples of a mixture containing Cry1Ac, amorphous inclusions, and spores maintained chitinase activity. Amorphous inclusions could not be separated from Cry1Ac crystals by sucrose gradient centrifugation. Interestingly, the chitinase activity of purified Cry1Ac/amorphous inclusions was 51-fold higher compared to purified Cry1Ac inclusions of parental HD73, indicating that the increased enzymatic activity was due primarily to the presence of the atypical amorphous component. The possibility that the chimera is occluded with the Cry1Ac crystal, thereby contributing to the increased endochitinolytic activity, cannot be excluded. Finally, bioassays against larvae of Spodoptera frugiperda with spore/crystals of HD73 or spore-crystal ChiA74∆sp chimeric inclusions of recombinant HD73 strain showed LC 50 s of 396.86 and 290.25 ng/cm 2 , respectively. Our study suggests a possible practical application of the chimera in formulations of B. thuringiensis-based lepidopteran larvicides.