WorldWideScience

Sample records for high costs limited

  1. Photovoltaic energy cost limit

    International Nuclear Information System (INIS)

    Coiante, D.

    1992-01-01

    Referring to a photovoltaic system for grid connected applications, a parametric expression of kWh cost is derived. The limit of kWh cost is carried out extrapolating the values of cost components to their lowest figure. The reliability of the forecast is checked by disaggregating kWh cost in direct and indirect costs and by discussing the possible cost reduction of each component

  2. Cost allocation with limited information

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Tind, Jørgen

    This article investigates progressive development of Aumann-Shapley cost allocation in a multilevel organizational or production structure. In particular, we study a linear parametric programming setup utilizing the Dantzig-Wolfe decomposition procedure. Typically cost allocation takes place after...... all activities have been performed, for example by finishing all outputs. Here the allocation is made progressively with suggestions for activities. I other words cost allocation is performed in parallel for example with a production planning process. This development does not require detailed...... information about some technical constraints in order to make the cost allocation....

  3. TU-G-BRCD-01: Will the High Cost of Proton Therapy Facilities Limit the Availability of Proton Therapy Treatment?

    Science.gov (United States)

    Maughan, R

    2012-06-01

    The potential dose distribution advantages associated with proton therapy, and particularly with pencil beam scanning (PBS) techniques, have lead to considerable interest in this modality in recent years. However, the large capital expenditure necessary for such a project requires careful financial consideration and business planning. The complexity of the beam delivery systems impacts the capital expenditure and the PBS only systems presently being advocated can reduce these costs. Also several manufacturers are considering "one-room" facilities as less expensive alternatives to multi-room facilities. This presentation includes a brief introduction to beam delivery options (passive scattering, uniform and modulated scanning) and some of the new technologies proposed for providing less expensive proton therapy systems. Based on current experience, data on proton therapy center start-up costs, running costs and the financial challenges associated with making this highly conformal therapy more widely available will be discussed. Issues associated with proton therapy implementation that are key to project success include strong project management, vendor cooperation and collaboration, staff recruitment and training. Time management during facility start up is a major concern, particularly in multi-room systems, where time must be shared between continuing vendor system validation, verification and acceptance testing, and user commissioning and patient treatments. The challenges associated with facility operation during this period and beyond are discussed, focusing on how standardization of process, downtime and smart scheduling can influence operational efficiency. 1. To understand the available choices for proton therapy facilities, the different beam delivery systems and the financial implications associated with these choices. 2. To understand the key elements necessary for successfully implementing a proton therapy program. 3. To understand the challenges

  4. Cycling of conventional power plants: Technical limits and actual costs

    International Nuclear Information System (INIS)

    Van den Bergh, Kenneth; Delarue, Erik

    2015-01-01

    Highlights: • Literature reports a wide range of cycling parameters (technical and cost-related). • The impact of different cycling parameters is assessed. • The German 2013 system is studied as a case study. • Even for stringent parameters, the dynamic limit of the portfolio is not reached. • Cycling costs can be reduced with 40% when taken into account in the scheduling. - Abstract: Cycling of conventional generation units is an important source of operational flexibility in the electricity generation system. Cycling is changing the power output of conventional units by means of ramping and switching (starting up and shutting down). In the literature, a wide range of technical and cost-related cycling parameters can be found. Different studies allocate different cycling parameters to similar generation units. This paper assesses the impact of different cycling parameters allocated to a conventional generation portfolio. Both the technical limitations of power plants and all costs related to cycling are considered. The results presented in this paper follow from a unit commitment model, used for a case study based on the German 2013 system. The conventional generation portfolio has to deliver different residual load time series, corresponding to different levels of renewables penetration. The study shows, under the assumptions made, that although the dynamic limits of some units are reached, the limits of the conventional generation portfolio as a whole are not reached, even if stringent dynamic parameters are assigned to the generation portfolio and a highly variable residual load is imposed to the system. The study shows also the importance of including full cycling costs in the unit commitment scheduling. The cycling cost can be reduced by up to 40% when fully taken into account

  5. 20 CFR 631.62 - Cost limitations.

    Science.gov (United States)

    2010-04-01

    ... Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROGRAMS UNDER TITLE III OF THE JOB TRAINING PARTNERSHIP ACT Federal Delivery of Dislocated Worker Services Through National... not adequately justify to the Grant Officer's satisfaction the costs to be incorporated into the grant...

  6. Reducing health care costs - potential and limitations of local ...

    African Journals Online (AJOL)

    Reducing health care costs - potential and limitations of local authority health services. ... both the quality and the cost-effectiveness of health care would be improved. ... LAs offer an appropriate structure for effective community control over the ...

  7. 10 CFR 602.15 - Indirect cost limitations.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Indirect cost limitations. 602.15 Section 602.15 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL ASSISTANCE PROGRAM § 602.15 Indirect cost limitations. Awards issued under this part for conferences and...

  8. 10 CFR 605.16 - Indirect cost limitations.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Indirect cost limitations. 605.16 Section 605.16 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM § 605.16 Indirect cost limitations. Awards issued under this part for conferences and scientific...

  9. Cost optimisation studies of high power accelerators

    Energy Technology Data Exchange (ETDEWEB)

    McAdams, R.; Nightingale, M.P.S.; Godden, D. [AEA Technology, Oxon (United Kingdom)] [and others

    1995-10-01

    Cost optimisation studies are carried out for an accelerator based neutron source consisting of a series of linear accelerators. The characteristics of the lowest cost design for a given beam current and energy machine such as power and length are found to depend on the lifetime envisaged for it. For a fixed neutron yield it is preferable to have a low current, high energy machine. The benefits of superconducting technology are also investigated. A Separated Orbit Cyclotron (SOC) has the potential to reduce capital and operating costs and intial estimates for the transverse and longitudinal current limits of such machines are made.

  10. Fixed transaction costs and modelling limited dependent variables

    NARCIS (Netherlands)

    Hempenius, A.L.

    1994-01-01

    As an alternative to the Tobit model, for vectors of limited dependent variables, I suggest a model, which follows from explicitly using fixed costs, if appropriate of course, in the utility function of the decision-maker.

  11. 48 CFR 32.704 - Limitation of cost or funds.

    Science.gov (United States)

    2010-10-01

    ... GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 32.704 Limitation of cost or funds... contracting officer shall promptly give the contractor written notice of the decision not to provide funds. (b...

  12. A general approach to total repair cost limit replacement policies

    Directory of Open Access Journals (Sweden)

    F. Beichelt

    2014-01-01

    Full Text Available A common replacement policy for technical systems consists in replacing a system by a new one after its economic lifetime, i.e. at that moment when its long-run maintenance cost rate is minimal. However, the strict application of the economic lifetime does not take into account the individual deviations of maintenance cost rates of single systems from the average cost development. Hence, Beichet proposed the total repair cost limit replacement policy: the system is replaced by a new one as soon as its total repair cost reaches or exceeds a given level. He modelled the repair cost development by functions of the Wiener process with drift. Here the same policy is considered under the assumption that the one-dimensional probability distribution of the process describing the repair cost development is given. In the examples analysed, applying the total repair cost limit replacement policy instead of the economic life-time leads to cost savings of between 4% and 30%. Finally, it is illustrated how to include the reliability aspect into the policy.

  13. Maintenance cost savings - snubber elimination with limit stops

    International Nuclear Information System (INIS)

    Monette, P.; Baltus, R.; Cloud, R.L.

    1995-01-01

    ''Active'' snubbers can be replaced with ''passive'' Limit Stops using two separate strategies. One is a straightforward piping re-analysis to optimize the number of dynamics supports and replace remaining snubbers with Limit Stops. A second approach is to take implicit advantage of the margins afforded by the ASME Code Case N-411 damping ratios and simply replace snubbers one-for-one with no re-analysis. Both methods result in major maintenance cost savings and both have been received favorably by the USNRC (United States Nuclear Regulatory Commission). Approaches to maintenance cost reduction using these strategies are discussed in this paper. (Author). 11 refs., 4 figs

  14. Maintenance cost savings - snubber elimination with limit stops

    International Nuclear Information System (INIS)

    Cloud, R.L.; Taylor, W.H.

    1993-01-01

    'Active' snubbers can be replaced with 'passive' Limit Stops using two separate strategies. One is a straightforward piping re-analysis to optimize the number of dynamic supports and replace remaining snubbers with Limit Stops. A second approach is to take implicit advantage of the margins afforded by the ASME Code Case N-411 reduced damping ratios and simply replace snubbers one-for-one with no re-analysis. Both methods result in major maintenance cost savings and both have been discussed with the NRC. Approaches to maintenance cost reduction using these strategies are discussed in this paper

  15. Innovative Feed-In Tariff Designs that Limit Policy Costs

    Energy Technology Data Exchange (ETDEWEB)

    Kreycik, C.; Couture, T. D.; Cory, K. S.

    2011-06-01

    Feed-in tariffs (FITs) are the most prevalent renewable energy policy used globally to date, and there are many benefits to the certainty offered in the marketplace to reduce development risks and associated financing costs and to grow the renewable energy industry. However, concerns over escalating costs in jurisdictions with FIT policies have led to increased attention on cost control in renewable energy policy design. In recent years, policy mechanisms for containing FIT costs have become more refined, allowing policymakers to exert greater control on policy outcomes and on the resulting costs to ratepayers. As policymakers and regulators in the United States begin to explore the use of FITs, careful consideration must be given to the ways in which policy design can be used to balance the policies' advantages while bounding its costs. This report explores mechanisms that policymakers have implemented to limit FIT policy costs. If designed clearly and transparently, such mechanisms can align policymaker and market expectations for project deployment. Three different policy tools are evaluated: (1) caps, (2) payment level adjustment mechanisms, and (3) auction-based designs. The report employs case studies to explore the strengths and weaknesses of these three cost containment tools. These tools are then evaluated with a set of criteria including predictability for policymakers and the marketplace and the potential for unintended consequences.

  16. 34 CFR 656.30 - What are allowable costs and limitations on allowable costs?

    Science.gov (United States)

    2010-07-01

    ... FOREIGN LANGUAGE AND AREA STUDIES OR FOREIGN LANGUAGE AND INTERNATIONAL STUDIES What Conditions Must Be... 34 Education 3 2010-07-01 2010-07-01 false What are allowable costs and limitations on allowable costs? 656.30 Section 656.30 Education Regulations of the Offices of the Department of Education...

  17. High Efficiency, Low Cost Scintillators for PET

    International Nuclear Information System (INIS)

    Kanai Shah

    2007-01-01

    Inorganic scintillation detectors coupled to PMTs are an important element of medical imaging applications such as positron emission tomography (PET). Performance as well as cost of these systems is limited by the properties of the scintillation detectors available at present. The Phase I project was aimed at demonstrating the feasibility of producing high performance scintillators using a low cost fabrication approach. Samples of these scintillators were produced and their performance was evaluated. Overall, the Phase I effort was very successful. The Phase II project will be aimed at advancing the new scintillation technology for PET. Large samples of the new scintillators will be produced and their performance will be evaluated. PET modules based on the new scintillators will also be built and characterized

  18. THE BREAKEVEN POINT GIVEN LIMIT COST USING BIOMASS CHP PLANT

    Directory of Open Access Journals (Sweden)

    Paula VOICU

    2015-06-01

    Full Text Available Biomass is a renewable source, non-fossil, from which can be obtained fuels, which can be used in power generation systems. The main difference of fossil fuels is the availability biomass in nature and that it is in continue "reproduction". The use its enable the use of materials that could be destined destruction, as a source of energy "renewable", though result with many ecological values. In this paper we will study, applying a calculation model in view optimal sizing of the cogeneration plant based on biomass, biomass cost limit for the net present value is zero. It will consider that in cogeneration systems and in heating peak systems using biomass. After applying the mathematical model for limit value of biomass cost will determine the nominal optimal coefficient of cogeneration, for which discounted net revenue value is zero. Optimal sizing of CHP plants based on using biomass will be given by optimum coefficient of cogeneration determined following the application of the proposed mathematical model.

  19. The indirect costs and benefits of greenhouse gas limitations

    Energy Technology Data Exchange (ETDEWEB)

    Markandya, A.

    1998-12-31

    The purpose of this report is to evaluate GHG limitation issues in a broader context. This includes the impacts of projects on vulnerable groups, the impacts on the environment more generally and the impacts on sustainability in a wider sense. It also offers some advice on how a decision-making framework can bring together these different dimensions. The structure of the guidelines is as follows. Section 2 introduces essential cost concepts and discusses the adjustments needed to the financial costs of different components, to arrive at the true economic costs. Section 3 looks at the macro-economic impacts of different GHG limitation project/policies. Section 4 discusses the way in which the sustainability concerns of such projects/policies can be monitored. Section 5 brings these different components together and looks at different methods of project selection. Section 6 provides a basic framework of impacts that are likely to arise in different GHG-related projects/policies, and what kind of method of estimation is available for these different impacts. Sections 7 to 9 go into greater depth on specific impacts. Sections 7 and 8 look at the employment and distributional effects respectively, and how they might be estimated. Section 9 evaluates the benefits in terms of changes in environmental damage resulting from GHG projects/policies. Section 10 provides three case studies in which the methods outlined in the report are applied. These case studies consider a biogas plant in Tanzania, a forestry project in the Russian Federation, and an energy efficiency project in Thailand. Section 11 concludes the report. (au) 59 refs.

  20. The indirect costs and benefits of greenhouse gas limitations

    Energy Technology Data Exchange (ETDEWEB)

    Markandya, A

    1999-12-31

    The purpose of this report is to evaluate GHG limitation issues in a broader context. This includes the impacts of projects on vulnerable groups, the impacts on the environment more generally and the impacts on sustainability in a wider sense. It also offers some advice on how a decision-making framework can bring together these different dimensions. The structure of the guidelines is as follows. Section 2 introduces essential cost concepts and discusses the adjustments needed to the financial costs of different components, to arrive at the true economic costs. Section 3 looks at the macro-economic impacts of different GHG limitation project/policies. Section 4 discusses the way in which the sustainability concerns of such projects/policies can be monitored. Section 5 brings these different components together and looks at different methods of project selection. Section 6 provides a basic framework of impacts that are likely to arise in different GHG-related projects/policies, and what kind of method of estimation is available for these different impacts. Sections 7 to 9 go into greater depth on specific impacts. Sections 7 and 8 look at the employment and distributional effects respectively, and how they might be estimated. Section 9 evaluates the benefits in terms of changes in environmental damage resulting from GHG projects/policies. Section 10 provides three case studies in which the methods outlined in the report are applied. These case studies consider a biogas plant in Tanzania, a forestry project in the Russian Federation, and an energy efficiency project in Thailand. Section 11 concludes the report. (au) 59 refs.

  1. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What types of costs are subject to the... § 286.55 What types of costs are subject to the administrative cost limit on Tribal Family Assistance... tracking, data entry and monitoring, including personnel and other costs associated with the automation...

  2. High cost for drilling ships

    International Nuclear Information System (INIS)

    Hooghiemstra, J.

    2007-01-01

    Prices for the rent of a drilling ship are very high. Per day the rent is 1% of the price for building such a ship, and those prices have risen as well. Still, it is attractive for oil companies to rent a drilling ship [nl

  3. Innovative Feed-In Tariff Designs that Limit Policy Costs

    Energy Technology Data Exchange (ETDEWEB)

    Kreycik, Claire [National Renewable Energy Lab. (NREL), Golden, CO (United States); Couture, Toby D. [E3 Analytics, Berlin (Germany); Cory, Karlynn S. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2011-06-01

    Feed-in tariffs (FITs) are the most prevalent policy used globally to reduce development risks, cut financing costs, and grow the renewable energy industry. However, concerns over escalating costs in jurisdictions with FIT policies have led to increased attention on cost control. Using case studies and market-focused analysis, this report from the National Renewable Energy Laboratory (NREL) examines strengths and weaknesses of three cost-containment tools: (1) caps, (2) payment level adjustment mechanisms, and (3) auction-based designs. The report provides useful insights on containing costs for policymakers and regulators in the United States and other areas where FIT policies are in development.

  4. High-cost users of medical care

    OpenAIRE

    Garfinkel, Steven A.; Riley, Gerald F.; Iannacchione, Vincent G.

    1988-01-01

    Based on data from the National Medical Care Utilization and Expenditure Survey, the 10 percent of the noninstitutionalized U.S. population that incurred the highest medical care charges was responsible for 75 percent of all incurred charges. Health status was the strongest predictor of high-cost use, followed by economic factors. Persons 65 years of age or over incurred far higher costs than younger persons and had higher out-of-pocket costs, absolutely and as a percentage of income, althoug...

  5. The high cost of conflict.

    Science.gov (United States)

    Forté, P S

    1997-01-01

    Conflict is inevitable, especially in highly stressed environments. Clinical environments marked by nurse-physician conflict (and nurse withdrawal related to conflict avoidance) have been proven to be counterproductive to patients. Clinical environments with nurse-physician professional collegiality and respectful communication show decreased patient morbidity and mortality, thus enhancing outcomes. The growth of managed care, and the organizational turmoil associated with rapid change, makes it imperative to structure the health care environment so that conflict can be dealt with in a safe and healthy manner. Professional health care education programs and employers have a responsibility to provide interactive opportunities for multidisciplinary audiences through which conflict management skills can be learned and truly change the interpersonal environment. Professionals must be free to focus their energy on the needs of the patient, not on staff difficulties.

  6. Low-cost high purity production

    Science.gov (United States)

    Kapur, V. K.

    1978-01-01

    Economical process produces high-purity silicon crystals suitable for use in solar cells. Reaction is strongly exothermic and can be initiated at relatively low temperature, making it potentially suitable for development into low-cost commercial process. Important advantages include exothermic character and comparatively low process temperatures. These could lead to significant savings in equipment and energy costs.

  7. The cost of failing states and the limits to sovereignty

    OpenAIRE

    Chauvet, Lisa; Collier, Paul; Hoeffler, Anke

    2007-01-01

    In this paper, we estimate the costs of state failure, both for the failing state itself and for its neighbours. In our analysis, the cost of failure arises from two distinct sources: organized violence due to the incapacity of the state to ensure its own citizens’ security and low quality of regulation and public goods due to poor governance. To estimate the cost of failure, we proceed in two steps. First we estimate the annual loss of growth induced by state failure. Then we cumulate this l...

  8. Health insurance without provider influence: the limits of cost containment.

    Science.gov (United States)

    Goldberg, L G; Greenberg, W

    1988-01-01

    In our previous paper, we showed that market forces can play a significant role in controlling health care costs and that a considerable amount of cost containment effort was pursued by third-party insurers in Oregon in the 1930s and 1940s. Although physicians were able to thwart this cost-control effort, a 1986 Supreme Court decision, FTC v. Indiana Federation of Dentists, found that a boycott of insurers by dentists violated Section 5 of the Federal Trade Commission Act. Further investigation of recent developments, including the recent Wickline v. California decision, indicates that the primary barriers to cost containment today are not obstructive tactics by providers or provider-controlled health insurance plans. Rather, the primary barriers are increases in the development and diffusion of new technology and society's apparent preference for paying for new tests and procedures regardless of economic efficiency.

  9. 40 CFR 35.925-18 - Limitation upon project costs incurred prior to award.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Limitation upon project costs incurred...-Clean Water Act § 35.925-18 Limitation upon project costs incurred prior to award. That project... project costs in the following cases: (1) Step 1 work begun after the date of approval by the Regional...

  10. Assessment of a New Lower-Cost Real-Time PCR Assay for Detection of High-Risk Human Papillomavirus: Useful for Cervical Screening in Limited-Resource Settings?

    Science.gov (United States)

    Fokom Domgue, Joel; Schiffman, Mark; Wentzensen, Nicolas H; Gage, Julia C; Castle, Philip E; Raine-Bennett, Tina R; Fetterman, Barbara; Lorey, Thomas; Poitras, Nancy E; Befano, Brian; Xie, Yi; Miachon, Lais S; Dean, Michael

    2017-08-01

    Inexpensive and easy-to-perform human papillomavirus (HPV) tests are needed for primary cervical cancer screening in lower-resource regions. In a convenience sample of 516 residual exfoliative cervical specimens from the Kaiser Permanente Northern California and U.S. National Cancer Institute Persistence and Progression Study, we assessed the agreement and clinical performance of a simple, inexpensive real-time PCR assay for the detection of 13 carcinogenic HPV types (the H13 assay; Hybribio, Hong Kong) that is marketed in limited-resource settings compared to previous testing by the Hybrid Capture 2 assay (HC2; Qiagen, Germantown, MD) and the Onclarity assay (BD Diagnostics, Sparks, MD). The test set was chosen to include many HPV-positive specimens. The reference standard was a combination of HC2 and Onclarity results for HPV detection and histologic diagnosis of controls (less than cervical intraepithelial neoplasia grade 2 [cost HPV DNA test that might be useful for primary screening in limited-resource settings. Copyright © 2017 American Society for Microbiology.

  11. Evaluating the Cost of Line Capacity Limitations in Aggregations of Commercial Buildings

    DEFF Research Database (Denmark)

    Ziras, Charalampos; Delikaraoglou, Stefanos; Kazempour, Jalal

    2017-01-01

    -ahead optimization strategy to assess the cost of imposing capacity limitations in the total consumption of individual buildings, as well as aggregations of buildings. We show that such capacity limitations lead to an increase for the buildings operational costs, which can be interpreted as the value...... of these limitations. Based on such calculations, the aggregator can value capacity-limitation services to the distribution system operator. Moreover, the value of aggregation is also highlighted, since it leads to lower costs than imposing the same total capacity limitation on individual buildings....

  12. 78 FR 8389 - Natural Gas Pipelines; Project Cost and Annual Limits

    Science.gov (United States)

    2013-02-06

    ... Director of the Office of Energy Projects. The cost limits for calendar year 2013, as published in Table I.... ACTION: Final rule. SUMMARY: Pursuant to the authority delegated by 18 CFR 375.308(x)(1), the Director of the Office of Energy Projects (OEP) computes and publishes the project cost and annual limits for...

  13. Low Cost, Low Power, High Sensitivity Magnetometer

    Science.gov (United States)

    2008-12-01

    which are used to measure the small magnetic signals from brain. Other types of vector magnetometers are fluxgate , coil based, and magnetoresistance...concentrator with the magnetometer currently used in Army multimodal sensor systems, the Brown fluxgate . One sees the MEMS fluxgate magnetometer is...Guedes, A.; et al., 2008: Hybrid - LOW COST, LOW POWER, HIGH SENSITIVITY MAGNETOMETER A.S. Edelstein*, James E. Burnette, Greg A. Fischer, M.G

  14. Novel Low Cost, High Reliability Wind Turbine Drivetrain

    Energy Technology Data Exchange (ETDEWEB)

    Chobot, Anthony; Das, Debarshi; Mayer, Tyler; Markey, Zach; Martinson, Tim; Reeve, Hayden; Attridge, Paul; El-Wardany, Tahany

    2012-09-13

    Clipper Windpower, in collaboration with United Technologies Research Center, the National Renewable Energy Laboratory, and Hamilton Sundstrand Corporation, developed a low-cost, deflection-compliant, reliable, and serviceable chain drive speed increaser. This chain and sprocket drivetrain design offers significant breakthroughs in the areas of cost and serviceability and addresses the key challenges of current geared and direct-drive systems. The use of gearboxes has proven to be challenging; the large torques and bending loads associated with use in large multi-MW wind applications have generally limited demonstrated lifetime to 8-10 years [1]. The large cost of gearbox replacement and the required use of large, expensive cranes can result in gearbox replacement costs on the order of $1M, representing a significant impact to overall cost of energy (COE). Direct-drive machines eliminate the gearbox, thereby targeting increased reliability and reduced life-cycle cost. However, the slow rotational speeds require very large and costly generators, which also typically have an undesirable dependence on expensive rare-earth magnet materials and large structural penalties for precise air gap control. The cost of rare-earth materials has increased 20X in the last 8 years representing a key risk to ever realizing the promised cost of energy reductions from direct-drive generators. A common challenge to both geared and direct drive architectures is a limited ability to manage input shaft deflections. The proposed Clipper drivetrain is deflection-compliant, insulating later drivetrain stages and generators from off-axis loads. The system is modular, allowing for all key parts to be removed and replaced without the use of a high capacity crane. Finally, the technology modularity allows for scalability and many possible drivetrain topologies. These benefits enable reductions in drivetrain capital cost by 10.0%, levelized replacement and O&M costs by 26.7%, and overall cost of

  15. The indirect costs and benefits of greenhouse gas limitations: Mauritius case study

    Energy Technology Data Exchange (ETDEWEB)

    Markandya, A.; Boyd, R.

    1999-09-01

    There has been a considerable amount of work carried out on the appraisal of different projects and programmes that reduce greenhouse gases (GHGs). These studies have focused on the development of appropriate methodologies for estimating of the costs of GHG limitation, and measuring the amount of GHGs abated. These are two of the central issues that need to be considered prior to finalising a policy for GHG mitigation, and ideally one would pursue those policy measures that effectively reduce GHGs at least cost. Although the cost (when correctly measured) should have a strong bearing on which policies to select, it is not the only consideration. Other factors will influence the decision, such as the impacts of the policies on different social groups in society, particularly on vulnerable groups, the benefits of the GHG limitation in other spheres (e.g. reduced air pollution), and the impacts of the policies on broader concern such as sustainability. In developing countries these other factors are even more important than they are in the industrialised countries. GHG limitation does not have as high a priority relative to other goals; such as poverty alleviation, reductions in employment, etc. as it does in the wealthier countries. Indeed, one can argue that the major focus of policy will be development, poverty alleviation etc. and that GHG limitation will be an addendum to a programme designed to meet those needs. Taking account of the GHG component may change the detailed design of a policy or programme, rather than being the main issue that determines the policy. In recognition of the importance of these broader social and environmental issues in developing countries, a methodology has been developed which provides a framework for the assessment of the wider impacts arising from GHG limitation projects, and advice on how to incorporate them into the decision-making framework. The purpose of this report is to apply the methodology to a set of selected GHG

  16. On-line determination of operating limits incorporating constraint costs and reliability assessment

    International Nuclear Information System (INIS)

    Meisingset, M.; Lovas, G. G.

    1997-01-01

    Problems regarding power system operation following deregulation were discussed. The problems arise as a result of the increased power flow pattern created by deregulation and competitive power markets, resulting in power in excess of N-1, (the capacity of transmission lines available), which in turn creates bottlenecks. In a situation like this, constraint costs and security costs (i.e. the cost of supply interruptions) are incurred as the direct result of the deterministic criteria used in reliability assessment. This paper describes an on-line probabilistic method to determine operating limits based on a trade-off between constraint costs and security costs. The probability of the contingencies depend on the existing weather conditions, which therefore has significant impact on the calculated operating limit. In consequence, the proposed method allows power flow to exceed the N-1 limit during normal weather. Under adverse weather conditions the N-1 criteria should be maintained. 15 refs., 13 figs

  17. 38 CFR 21.258 - Cost limitations on approval of self-employment plans.

    Science.gov (United States)

    2010-07-01

    ... approval of self-employment plans. 21.258 Section 21.258 Pensions, Bonuses, and Veterans' Relief DEPARTMENT... Employment Under 38 U.S.C. Chapter 31 Employment Services § 21.258 Cost limitations on approval of self-employment plans. A self-employment plan with an estimated or actual cost of less than $25,000 may be...

  18. Low cost high performance uncertainty quantification

    KAUST Repository

    Bekas, C.

    2009-01-01

    Uncertainty quantification in risk analysis has become a key application. In this context, computing the diagonal of inverse covariance matrices is of paramount importance. Standard techniques, that employ matrix factorizations, incur a cubic cost which quickly becomes intractable with the current explosion of data sizes. In this work we reduce this complexity to quadratic with the synergy of two algorithms that gracefully complement each other and lead to a radically different approach. First, we turned to stochastic estimation of the diagonal. This allowed us to cast the problem as a linear system with a relatively small number of multiple right hand sides. Second, for this linear system we developed a novel, mixed precision, iterative refinement scheme, which uses iterative solvers instead of matrix factorizations. We demonstrate that the new framework not only achieves the much needed quadratic cost but in addition offers excellent opportunities for scaling at massively parallel environments. We based our implementation on BLAS 3 kernels that ensure very high processor performance. We achieved a peak performance of 730 TFlops on 72 BG/P racks, with a sustained performance 73% of theoretical peak. We stress that the techniques presented in this work are quite general and applicable to several other important applications. Copyright © 2009 ACM.

  19. Oral nutritional support in malnourished elderly decreases functional limitations with no extra costs.

    Science.gov (United States)

    Neelemaat, Floor; Bosmans, Judith E; Thijs, Abel; Seidell, Jaap C; van Bokhorst-de van der Schueren, Marian A E

    2012-04-01

    Older people are vulnerable to malnutrition which leads to increased health care costs. The aim of this study was to evaluate the cost-effectiveness of nutritional supplementation from a societal perspective. This randomized controlled trial included hospital admitted malnourished elderly (≥ 60 y) patients. Patients in the intervention group received nutritional supplementation (energy and protein enriched diet, oral nutritional support, calcium-vitamin D supplement, telephone counselling by a dietician) until three months after discharge from hospital. Patients in the control group received usual care (control). Primary outcomes were Quality Adjusted Life Years (QALYs), physical activities and functional limitations. Measurements were performed at hospital admission and three months after discharge. Data were analyzed according to the intention-to-treat principle and multiple imputation was used to impute missing data. Incremental cost-effectiveness ratios were calculated and bootstrapping was applied to evaluate cost-effectiveness. Cost-effectiveness was expressed by cost-effectiveness planes and cost-effectiveness acceptability curves. 210 patients were included, 105 in each group. After three months, no statistically significant differences in quality of life and physical activities were observed between groups. Functional limitations decreased significantly more in the intervention group (mean difference -0.72, 95% CI-1.15; -0.28). There were no differences in costs between groups. Cost-effectiveness for QALYs and physical activities could not be demonstrated. For functional limitations we found a 0.95 probability that the intervention is cost-effective in comparison with usual care for ceiling ratios > €6500. A multi-component nutritional intervention to malnourished elderly patients for three months after hospital discharge leads to significant improvement in functional limitations and is neutral in costs. A follow-up of three months is probably too

  20. Low-Cost High-Performance MRI

    Science.gov (United States)

    Sarracanie, Mathieu; Lapierre, Cristen D.; Salameh, Najat; Waddington, David E. J.; Witzel, Thomas; Rosen, Matthew S.

    2015-10-01

    Magnetic Resonance Imaging (MRI) is unparalleled in its ability to visualize anatomical structure and function non-invasively with high spatial and temporal resolution. Yet to overcome the low sensitivity inherent in inductive detection of weakly polarized nuclear spins, the vast majority of clinical MRI scanners employ superconducting magnets producing very high magnetic fields. Commonly found at 1.5-3 tesla (T), these powerful magnets are massive and have very strict infrastructure demands that preclude operation in many environments. MRI scanners are costly to purchase, site, and maintain, with the purchase price approaching $1 M per tesla (T) of magnetic field. We present here a remarkably simple, non-cryogenic approach to high-performance human MRI at ultra-low magnetic field, whereby modern under-sampling strategies are combined with fully-refocused dynamic spin control using steady-state free precession techniques. At 6.5 mT (more than 450 times lower than clinical MRI scanners) we demonstrate (2.5 × 3.5 × 8.5) mm3 imaging resolution in the living human brain using a simple, open-geometry electromagnet, with 3D image acquisition over the entire brain in 6 minutes. We contend that these practical ultra-low magnetic field implementations of MRI (standards for affordable (<$50,000) and robust portable devices.

  1. Hybrid 21 MW wind-solar system to limit energy costs at an industrial plant

    International Nuclear Information System (INIS)

    López, C.

    2016-01-01

    Ereda has undertaken a project that aims to analyse the possibility of limiting the cost of the energy supply to a medium-sized industrial plant, with an installed capacity of over 26 MW, located in the south-west of Kazakhstan. The cost of electricity for its processes accounts for an important part of its production cost, achieving values in excess of 40%. The price of electricity in the country is expected to rise over the coming years. In addition, the plant is now required to reduce CO2 emissions from its industrial activity, which is why a further cost arising from the acquisition of emissions rights is expected in future. (Author)

  2. 77 FR 8724 - Natural Gas Pipelines; Project Cost and Annual Limits

    Science.gov (United States)

    2012-02-15

    ...] Natural Gas Pipelines; Project Cost and Annual Limits February 9, 2012. AGENCY: Federal Energy Regulatory... limits for natural gas pipelines blanket construction certificates for each calendar year. DATES: This... CFR Part 157 Administrative practice and procedure, Natural gas, Reporting and recordkeeping...

  3. High-density limit of quantum chromodynamics

    International Nuclear Information System (INIS)

    Alvarez, E.

    1983-01-01

    By means of a formal expansion of the partition function presumably valid at large baryon densities, the propagator of the quarks is expressed in terms of the gluon propagator. This result is interpreted as implying that correlations between quarks and gluons are unimportant at high enough density, so that a kind of mean-field approximation gives a very accurate description of the physical system

  4. Limiting liability via high resolution image processing

    Energy Technology Data Exchange (ETDEWEB)

    Greenwade, L.E.; Overlin, T.K.

    1996-12-31

    The utilization of high resolution image processing allows forensic analysts and visualization scientists to assist detectives by enhancing field photographs, and by providing the tools and training to increase the quality and usability of field photos. Through the use of digitized photographs and computerized enhancement software, field evidence can be obtained and processed as `evidence ready`, even in poor lighting and shadowed conditions or darkened rooms. These images, which are most often unusable when taken with standard camera equipment, can be shot in the worst of photographic condition and be processed as usable evidence. Visualization scientists have taken the use of digital photographic image processing and moved the process of crime scene photos into the technology age. The use of high resolution technology will assist law enforcement in making better use of crime scene photography and positive identification of prints. Valuable court room and investigation time can be saved and better served by this accurate, performance based process. Inconclusive evidence does not lead to convictions. Enhancement of the photographic capability helps solve one major problem with crime scene photos, that if taken with standard equipment and without the benefit of enhancement software would be inconclusive, thus allowing guilty parties to be set free due to lack of evidence.

  5. Limitations of high dose carrier based formulations.

    Science.gov (United States)

    Yeung, Stewart; Traini, Daniela; Tweedie, Alan; Lewis, David; Church, Tanya; Young, Paul M

    2018-06-10

    This study was performed to investigate how increasing the active pharmaceutical ingredient (API) content within a formulation affects the dispersion of particles and the aerosol performance efficiency of a carrier based dry powder inhalable (DPI) formulation, using a custom dry powder inhaler (DPI) development rig. Five formulations with varying concentrations of API beclomethasone dipropionate (BDP) between 1% and 30% (w/w) were formulated as a multi-component carrier system containing coarse lactose and fine lactose with magnesium stearate. The morphology of the formulation and each component were investigated using scanning electron micrographs while the particle size was measured by laser diffraction. The aerosol performance, in terms of aerodynamic diameter, was assessed using the British pharmacopeia Apparatus E cascade impactor (Next generation impactor). Chemical analysis of the API was observed by high performance liquid chromatography (HPLC). Increasing the concentration of BDP in the blend resulted in increasing numbers and size of individual agglomerates and densely packed BDP multi-layers on the surface of the lactose carrier. BDP present within the multi-layer did not disperse as individual primary particles but as dense agglomerates, which led to a decrease in aerosol performance and increased percentage of BDP deposition within the Apparatus E induction port and pre-separator. As the BDP concentration in the blends increases, aerosol performance of the formulation decreases, in an inversely proportional manner. Concurrently, the percentage of API deposition in the induction port and pre-separator could also be linked to the amount of micronized particles (BDP and Micronized composite carrier) present in the formulation. The effect of such dose increase on the behaviour of aerosol dispersion was investigated to gain greater insight in the development and optimisation of higher dosed carrier-based formulations. Copyright © 2018 Elsevier B.V. All

  6. Low Cost, High Efficiency, High Pressure Hydrogen Storage

    Energy Technology Data Exchange (ETDEWEB)

    Mark Leavitt

    2010-03-31

    A technical and design evaluation was carried out to meet DOE hydrogen fuel targets for 2010. These targets consisted of a system gravimetric capacity of 2.0 kWh/kg, a system volumetric capacity of 1.5 kWh/L and a system cost of $4/kWh. In compressed hydrogen storage systems, the vast majority of the weight and volume is associated with the hydrogen storage tank. In order to meet gravimetric targets for compressed hydrogen tanks, 10,000 psi carbon resin composites were used to provide the high strength required as well as low weight. For the 10,000 psi tanks, carbon fiber is the largest portion of their cost. Quantum Technologies is a tier one hydrogen system supplier for automotive companies around the world. Over the course of the program Quantum focused on development of technology to allow the compressed hydrogen storage tank to meet DOE goals. At the start of the program in 2004 Quantum was supplying systems with a specific energy of 1.1-1.6 kWh/kg, a volumetric capacity of 1.3 kWh/L and a cost of $73/kWh. Based on the inequities between DOE targets and Quantum’s then current capabilities, focus was placed first on cost reduction and second on weight reduction. Both of these were to be accomplished without reduction of the fuel system’s performance or reliability. Three distinct areas were investigated; optimization of composite structures, development of “smart tanks” that could monitor health of tank thus allowing for lower design safety factor, and the development of “Cool Fuel” technology to allow higher density gas to be stored, thus allowing smaller/lower pressure tanks that would hold the required fuel supply. The second phase of the project deals with three additional distinct tasks focusing on composite structure optimization, liner optimization, and metal.

  7. Are PES connection costs too high?

    International Nuclear Information System (INIS)

    Scott, N.

    1998-01-01

    Windfarm developers often have good reason to question the costs they are quoted by their local distribution company for connection to the system, and these costs can now be challenged under the 'Competition in Connection' initiative. Econnect Ltd specialise in electrical connections for renewable generation throughout the UK and Europe, and have worked on many projects where alternative connections have been designed at more competitive prices. This paper provides some examples which illustrate the importance of acquiring a thorough understanding of all power system issues and PES concerns if the most cost-effective connection is to be realised. (Author)

  8. Limiting the costs of renewable portfolio standards: A review and critique of current methods

    International Nuclear Information System (INIS)

    Stockmayer, Gabriella; Finch, Vanessa; Komor, Paul; Mignogna, Rich

    2012-01-01

    Over half of U.S. states have renewable portfolio standards (RPSs) mandating that a minimum percentage of electricity sold derives from renewable sources. State RPSs vary widely in how they attempt to control or limit the costs of these RPSs. Approaches utilized include alternative compliance payments, direct rate caps, and cost caps on resource acquisitions, while some states employ no specific limitation at all. This paper describes how states attempt to control RPS costs and discusses the strengths and weaknesses of these various cost controls. There is no one best method; however the experience to date suggests that the most important factors in implementing an effective mechanism to curtail costs are clarity of the rule, consistency in application, and transparency for customers. - Highlights: ▶ We review states' RPS statutes and regulations for mechanisms that attempt to control overall compliance costs. ▶ We categorize the major cost curtailment mechanisms. ▶ For each mechanism, we describe policy designs that are or could be implemented by states. ▶ We identify strengths and weaknesses of the various designs for consideration by policymakers.

  9. Low cost high performance uncertainty quantification

    KAUST Repository

    Bekas, C.; Curioni, A.; Fedulova, I.

    2009-01-01

    Uncertainty quantification in risk analysis has become a key application. In this context, computing the diagonal of inverse covariance matrices is of paramount importance. Standard techniques, that employ matrix factorizations, incur a cubic cost

  10. High cost of nuclear power plants

    International Nuclear Information System (INIS)

    Bassett, C.

    1978-01-01

    Retroactive safety standards were found to account for over half the costs of a nuclear power plant and point up the need for an effective cost-benefit analysis of changes made by the Nuclear Regulatory Commission after construction has started. The author compared the Davis-Besse Unit No. 1 construction-cost estimates with the final-cost increases during a rate-case investigation in Ohio. He presents data furnished for ten of the largest construction contracts to illustrate the cost increases involving fixed hardware and intensive labor. The situation was found to repeat with other utilities across the country even though safeguards against irresponsible low bidding were introduced. Low bidding was found to continue, encouraged by the need for retrofitting to meet regulation changes. The average cost per kilowatt of major light-water reactors is shown to have increased from $171 in 1970 to $555 in 1977, while construction duration increased from 43.4 to 95.6 months during the same period

  11. Bureaucratic limits of firm size: Empirical analysis using transaction cost economics

    OpenAIRE

    Canbäck, Staffan

    2002-01-01

    This thesis was submitted for the degree of Doctor of Business Administration and awarded by Brunel University on behalf of Henley Management College This thesis tests Oliver Williamson’s proposition that transaction cost economics can explain the limits of firm size. Williamson suggests that diseconomies of scale are manifested through four interrelated factors: atmospheric consequences due to specialisation, bureaucratic insularity, incentive limits of the employment relation and communi...

  12. High and rising health care costs.

    Science.gov (United States)

    Ginsburg, Paul B

    2008-10-01

    The U.S. is spending a growing share of the GDP on health care, outpacing other industrialized countries. This synthesis examines why costs are higher in the U.S. and what is driving their growth. Key findings include: health care inefficiency, medical technology and health status (particularly obesity) are the primary drivers of rising U.S. health care costs. Health payer systems that reward inefficiencies and preempt competition have impeded productivity gains in the health care sector. The best evidence indicates medical technology accounts for one-half to two-thirds of spending growth. While medical malpractice insurance and defensive medicine contribute to health costs, they are not large enough factors to significantly contribute to a rise in spending. Research is consistent that demographics will not be a significant factor in driving spending despite the aging baby boomers.

  13. 34 CFR 658.40 - What are the limitations on allowable costs?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are the limitations on allowable costs? 658.40 Section 658.40 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION UNDERGRADUATE INTERNATIONAL STUDIES AND FOREIGN LANGUAGE...

  14. 34 CFR 660.40 - What are the limitations on allowable costs?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are the limitations on allowable costs? 660.40 Section 660.40 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM What Conditions...

  15. 76 FR 8293 - Natural Gas Pipelines; Project Cost and Annual Limits

    Science.gov (United States)

    2011-02-14

    ...] Natural Gas Pipelines; Project Cost and Annual Limits February 8, 2011. AGENCY: Federal Energy Regulatory... for natural gas pipelines blanket construction certificates for each calendar year. DATES: Effective... of Subjects in 18 CFR Part 157 Administrative practice and procedure, Natural Gas, Reporting and...

  16. 75 FR 8245 - Natural Gas Pipelines; Project Cost and Annual Limits

    Science.gov (United States)

    2010-02-24

    ...] Natural Gas Pipelines; Project Cost and Annual Limits February 18, 2010. AGENCY: Federal Energy Regulatory... for natural gas pipelines blanket construction certificates for each calendar year. DATES: This final..., Natural gas, Reporting and recordkeeping requirements. Jeff C. Wright, Director, Office of Energy Projects...

  17. The Impact of Debt Limitations and Referenda Requirements on the Cost of School District Bond Issues

    Science.gov (United States)

    Harris, Mary H.; Munley, Vincent G.

    2011-01-01

    One distinction between the markets for corporate and municipal bonds involves institutional constraints that apply to some municipal bond issues. This research focuses on how public finance institutions, in particular explicit debt limits and referenda requirements, affect the borrowing cost of individual school district bond issues. The…

  18. The costs of limiting fossil-fuel CO2 emissions: A survey and analysis

    International Nuclear Information System (INIS)

    Grubb, M.; Brink, P. ten; Morrison, M.

    1993-01-01

    In the late 1980s, interest flourished in the issue of global climate change. Many studies focused on the options for limiting anthropogenic emissions of greenhouse-related gases and managing the consequences of global warming and climate change. Making appropriate policy choices requires information on both the costs and benefits, as the occur over time, of policy interventions, and in increasing number of studies have sought to quantify the costs especially of limiting CO 2 emissions, as the dominant anthropogenic source. Such analyses now form an important part of overall policy assessments and influence international negotiations on policy responses. However, these studies are not well understood. In this paper the authors seek to analyze the literature on the costs of CO 2 abatement. 152 ref

  19. High cost of stage IV pressure ulcers.

    Science.gov (United States)

    Brem, Harold; Maggi, Jason; Nierman, David; Rolnitzky, Linda; Bell, David; Rennert, Robert; Golinko, Michael; Yan, Alan; Lyder, Courtney; Vladeck, Bruce

    2010-10-01

    The aim of this study was to calculate and analyze the cost of treatment for stage IV pressure ulcers. A retrospective chart analysis of patients with stage IV pressure ulcers was conducted. Hospital records and treatment outcomes of these patients were followed up for a maximum of 29 months and analyzed. Costs directly related to the treatment of pressure ulcers and their associated complications were calculated. Nineteen patients with stage IV pressure ulcers (11 hospital-acquired and 8 community-acquired) were identified and their charts were reviewed. The average hospital treatment cost associated with stage IV pressure ulcers and related complications was $129,248 for hospital-acquired ulcers during 1 admission, and $124,327 for community-acquired ulcers over an average of 4 admissions. The costs incurred from stage IV pressure ulcers are much greater than previously estimated. Halting the progression of early stage pressure ulcers has the potential to eradicate enormous pain and suffering, save thousands of lives, and reduce health care expenditures by millions of dollars. Copyright © 2010 Elsevier Inc. All rights reserved.

  20. The High Cost of Saving Energy Dollars.

    Science.gov (United States)

    Rose, Patricia

    1985-01-01

    In alternative financing a private company provides the capital and expertise for improving school energy efficiency. Savings are split between the school system and the company. Options for municipal leasing, cost sharing, and shared savings are explained along with financial, procedural, and legal considerations. (MLF)

  1. Negotiating NORM cleanup and land use limits: Practical use of dose assessment and cost benefit analysis

    International Nuclear Information System (INIS)

    Blanchard, A.D.H.

    1997-01-01

    Oil companies are presently faced with complex and costly environmental decisions, especially concerning NORM cleanup and disposal. Strict cleanup limits and disposal restrictions are established, in theory, to protect public health and environment. While public health is directly measured in terms of dose (mrem/yr), most NORM regulations adopt soil concentration limits to ensure future public health is maintained. These derived soil limits create the potential for unnecessary burden to operators without additional health benefit to society. Operators may use a dose assessment to show direct compliance with dose limits, negotiating less restrictive cleanup levels and land use limits. This paper discusses why a dose assessment is useful to Oilfield operators, NORM exposure scenarios and pathways, assessment advantages, variables and recommendations and one recent dose assessment application. Finally, a cost benefit analysis tool for regulatory negotiations will be presented allowing comparison of Oilfield NORM health benefit costs to that of other industries. One use for this tool--resulting in the savings of approximately $100,000--will be discussed

  2. Cost, affordability and cost-effectiveness of strategies to control tuberculosis in countries with high HIV prevalence

    Directory of Open Access Journals (Sweden)

    Williams Brian G

    2005-12-01

    Full Text Available Abstract Background The HIV epidemic has caused a dramatic increase in tuberculosis (TB in East and southern Africa. Several strategies have the potential to reduce the burden of TB in high HIV prevalence settings, and cost and cost-effectiveness analyses can help to prioritize them when budget constraints exist. However, published cost and cost-effectiveness studies are limited. Methods Our objective was to compare the cost, affordability and cost-effectiveness of seven strategies for reducing the burden of TB in countries with high HIV prevalence. A compartmental difference equation model of TB and HIV and recent cost data were used to assess the costs (year 2003 US$ prices and effects (TB cases averted, deaths averted, DALYs gained of these strategies in Kenya during the period 2004–2023. Results The three lowest cost and most cost-effective strategies were improving TB cure rates, improving TB case detection rates, and improving both together. The incremental cost of combined improvements to case detection and cure was below US$15 million per year (7.5% of year 2000 government health expenditure; the mean cost per DALY gained of these three strategies ranged from US$18 to US$34. Antiretroviral therapy (ART had the highest incremental costs, which by 2007 could be as large as total government health expenditures in year 2000. ART could also gain more DALYs than the other strategies, at a cost per DALY gained of around US$260 to US$530. Both the costs and effects of treatment for latent tuberculosis infection (TLTI for HIV+ individuals were low; the cost per DALY gained ranged from about US$85 to US$370. Averting one HIV infection for less than US$250 would be as cost-effective as improving TB case detection and cure rates to WHO target levels. Conclusion To reduce the burden of TB in high HIV prevalence settings, the immediate goal should be to increase TB case detection rates and, to the extent possible, improve TB cure rates, preferably

  3. High density regimes and beta limits in JET

    International Nuclear Information System (INIS)

    Smeulders, P.

    1990-01-01

    Results are first presented on the density limit in JET discharges with graphite (C), Be gettered graphite and Be limiters. There is a clear improvement in the case of Be limiters. The Be gettered phase showed no increase in the gas fueled density limit, except with Ion Cyclotron Resonance Heating (ICRH), but, the limit changed character. During MARFE-formation, any further increase in density was prevented, leading to a soft density limit. The soft density limit was a function of input power and impurity content with a week dependence on q. Helium and pellet fuelled discharges exceeded the gas-fuelled global density limits, but essentially had the same edge limit. In the second part, results are presented of high β operation in low-B Double-Null (DN) X-point configurations with Be-gettered carbon target plates. The Troyon limit was reached during H-mode discharges and toroidal β values of 5.5% were obtained. At high beta, the sawteeth were modified and characterised by very rapid heat-waves and fishbone-like pre- and post-cursors with strongly ballooning character. 17 refs., 5 figs

  4. Low cost highly available digital control computer

    International Nuclear Information System (INIS)

    Silvers, M.W.

    1986-01-01

    When designing digital controllers for critical plant control it is important to provide several features. Among these are reliability, availability, maintainability, environmental protection, and low cost. An examination of several applications has lead to a design that can be produced for approximately $20,000 (1000 control points). This design is compatible with modern concepts in distributed and hierarchical control. The canonical controller element is a dual-redundant self-checking computer that communicates with a cross-strapped, electrically isolated input/output system. The input/output subsystem comprises multiple intelligent input/output cards. These cards accept commands from the primary processor which are validated, executed, and acknowledged. Each card may be hot replaced to facilitate sparing. The implementation of the dual-redundant computer architecture is discussed. Called the FS-86, this computer can be used for a variety of applications. It has most recently found application in the upgrade of San Francisco's Bay Area Rapid Transit (BART) train control currently in progress and has been proposed for feedwater control in a boiling water reactor

  5. Social incidence and economic costs of carbon limits; A computable general equilibrium analysis for Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Stephan, G.; Van Nieuwkoop, R.; Wiedmer, T. (Institute for Applied Microeconomics, Univ. of Bern (Switzerland))

    1992-01-01

    Both distributional and allocational effects of limiting carbon dioxide emissions in a small and open economy are discussed. It starts from the assumption that Switzerland attempts to stabilize its greenhouse gas emissions over the next 25 years, and evaluates costs and benefits of the respective reduction programme. From a methodological viewpoint, it is illustrated how a computable general equilibrium approach can be adopted for identifying economic effects of cutting greenhouse gas emissions on the national level. From a political economy point of view it considers the social incidence of a greenhouse policy. It shows in particular that public acceptance can be increased and economic costs of greenhouse policies can be reduced, if carbon taxes are accompanied by revenue redistribution. 8 tabs., 1 app., 17 refs.

  6. 48 CFR 49.603-4 - Cost-reimbursement contracts-complete termination, with settlement limited to fee.

    Science.gov (United States)

    2010-10-01

    ... settlement limited to fee. [Insert the following in Block 14 of SF 30 for settlement of cost-reimbursement... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost-reimbursement contracts-complete termination, with settlement limited to fee. 49.603-4 Section 49.603-4 Federal...

  7. Parents and the High Cost of Child Care: 2012 Report

    Science.gov (United States)

    Child Care Aware of America, 2012

    2012-01-01

    "Parents and the High Cost of Child Care: 2012 Report" presents 2011 data reflecting what parents pay for full-time child care in America. It includes average fees for both child care centers and family child care homes. Information was collected through a survey conducted in January 2012 that asked for the average costs charged for…

  8. Comparative risk-benefit-cost effectiveness in nuclear and alternate power sources: methodology, perspective, limitations

    International Nuclear Information System (INIS)

    Vinck, W.; Van Reijen, G.; Maurer, H.; Volta, G.

    1980-01-01

    A critical survey is given of the use of quantitative risk assessment in defining acceptable limits of safety and of its use together with cost-benefit analyses for decision making. The paper indicates uncertainties and even unknowns in risk assessment in particular if the whole fuel cycle for energy production is considered. It is made clear that for decisions on acceptance of risk also the risk perception factor must be considered. A difficult issue here is the potential for low-probability/large consequence accidents. Examples are given, suggestions for improvement are made and perspectives are outlined

  9. Cost-appropriateness of whole body vs limited bone imaging for suspected focal sports injuries

    International Nuclear Information System (INIS)

    Nagle, C.E.

    1986-01-01

    Bone imaging has been recognized as a useful diagnostic tool in detecting the presence of focal musculoskeletal injury when radiographs are normal. A retrospective review of bone images in a small number of amateur athletes indicates that secondary injuries were commonly detected at sites different from the site of musculoskeletal pain being evaluated for injury. While a larger study will be necessary to confirm the data, this review suggests that it is medically justified and cost-appropriate to perform imaging of the entire skeleton as opposed to imaging limited to the anatomic site of pain and suspected injury

  10. Morse oscillator propagator in the high temperature limit I: Theory

    Energy Technology Data Exchange (ETDEWEB)

    Toutounji, Mohamad, E-mail: Mtoutounji@uaeu.ac.ae

    2017-02-15

    In an earlier work of the author the time evolution of Morse oscillator was studied analytically and exactly at low temperatures whereupon optical correlation functions were calculated using Morse oscillator coherent states were employed. Morse oscillator propagator in the high temperature limit is derived and a closed form of its corresponding canonical partition function is obtained. Both diagonal and off-diagonal forms of Morse oscillator propagator are derived in the high temperature limit. Partition functions of diatomic molecules are calculated. - Highlights: • Derives the quantum propagator of Morse oscillator in the high temperature limit. • Uses the resulting diagonal propagator to derive a closed form of Morse oscillator partition function. • Provides a more sophisticated formula of the quantum propagator to test the accuracy of the herein results.

  11. The indirect costs and benefits of greenhouse gas limitations: Hungary Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Zilahy, G.; Zsoka, A.N.; Szeszler, A.; Urge-Vorsatz, D.; Markandya, A.; Hunt, A.

    2000-05-01

    A methodology has been developed which provides a framework for the assessment of the wider impacts arising from GHG limitation projects, and advice on how to incorporate them into the decision-making framework. The purpose of this report is to apply the methodology to a set of selected GHG limitation projects currently being considered for implementation in Hungary. In total, four GHG limitation projects were selected for application of the methodology. This second phase of the research in Hungary, concentrated on four mitigation options in the household sector: Specifically, the selected GHG limitation projects involve: 1. The installation of new, better insulated windows. 2. The installation of water saving devices on water taps. 3. The installation of active solar cells to prepare domestic hot water. 4. The replacement of traditional light bulbs by compact fluorescent bulbs. This study has shown the potential, as well as the current pratical limitations, of the methodology. The value of the employment created has been estimated by adding gains in income effects with health effects. The environmental effects that have been quantified suggest that the reduction of pollution and associated health effects would be significant. The options that have been investigated are too small-scale to generate distributional impacts or macro-economic effects but the estimated effects on sustainability are positive and significant. The principal policy conclusion that can be drawn from the analysis thus far is that it is imperative to consider indirect effects. It is possible that inclusion of indirect effects will make the net economic cost of an option negative thereby making it much more easy to 'sell' as a policy measure - though the assumptions will have to be made explicit and therefore defensible. It is important for policy makers to note that whilst there is a general pattern of lower economic costs derived from this analysis, the reductions are not uniform and

  12. The indirect costs and benefits of greenhouse gas limitations: Hungary Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Zilahy, G; Zsoka, A N; Szeszler, A; Urge-Vorsatz, D; Markandya, A; Hunt, A

    2000-05-01

    A methodology has been developed which provides a framework for the assessment of the wider impacts arising from GHG limitation projects, and advice on how to incorporate them into the decision-making framework. The purpose of this report is to apply the methodology to a set of selected GHG limitation projects currently being considered for implementation in Hungary. In total, four GHG limitation projects were selected for application of the methodology. This second phase of the research in Hungary, concentrated on four mitigation options in the household sector: Specifically, the selected GHG limitation projects involve: 1. The installation of new, better insulated windows. 2. The installation of water saving devices on water taps. 3. The installation of active solar cells to prepare domestic hot water. 4. The replacement of traditional light bulbs by compact fluorescent bulbs. This study has shown the potential, as well as the current pratical limitations, of the methodology. The value of the employment created has been estimated by adding gains in income effects with health effects. The environmental effects that have been quantified suggest that the reduction of pollution and associated health effects would be significant. The options that have been investigated are too small-scale to generate distributional impacts or macro-economic effects but the estimated effects on sustainability are positive and significant. The principal policy conclusion that can be drawn from the analysis thus far is that it is imperative to consider indirect effects. It is possible that inclusion of indirect effects will make the net economic cost of an option negative thereby making it much more easy to 'sell' as a policy measure - though the assumptions will have to be made explicit and therefore defensible. It is important for policy makers to note that whilst there is a general pattern of lower economic costs derived from this analysis, the reductions are not uniform and

  13. Plant process computer replacements - techniques to limit installation schedules and costs

    International Nuclear Information System (INIS)

    Baker, M.D.; Olson, J.L.

    1992-01-01

    Plant process computer systems, a standard fixture in all nuclear power plants, are used to monitor and display important plant process parameters. Scanning thousands of field sensors and alarming out-of-limit values, these computer systems are heavily relied on by control room operators. The original nuclear steam supply system (NSSS) vendor for the power plant often supplied the plant process computer. Designed using sixties and seventies technology, a plant's original process computer has been obsolete for some time. Driven by increased maintenance costs and new US Nuclear Regulatory Commission regulations such as NUREG-0737, Suppl. 1, many utilities have replaced their process computers with more modern computer systems. Given that computer systems are by their nature prone to rapid obsolescence, this replacement cycle will likely repeat. A process computer replacement project can be a significant capital expenditure and must be performed during a scheduled refueling outage. The object of the installation process is to install a working system on schedule. Experience gained by supervising several computer replacement installations has taught lessons that, if applied, will shorten the schedule and limit the risk of costly delays. Examples illustrating this technique are given. This paper and these examples deal only with the installation process and assume that the replacement computer system has been adequately designed, and development and factory tested

  14. Kangaroo mother care in resource-limited settings: implementation, health benefits, and cost-effectiveness

    Directory of Open Access Journals (Sweden)

    Uwaezuoke SN

    2017-06-01

    Full Text Available Samuel N Uwaezuoke Department of Pediatrics, University of Nigeria Teaching Hospital, Ituku–Ozalla, Enugu, Nigeria Abstract: Kangaroo mother care (KMC represents an intervention in low birth weight infants for resource-limited settings which aims to reduce mortality rates by thermoregulation, supporting breastfeeding, and promoting early hospital discharge. In terms of cost and impact on neonatal survival, it has comparative advantages over the conventional method of care (CMC. This paper aimed to review the evidence concerning the progress of KMC implementation, its health benefits, and its cost-effectiveness, especially in developing countries. From the synthesized evidence, KMC was shown to be a useful adjunct to CMC particularly with respect to improving neonatal survival, supporting breastfeeding, and promoting early discharge from the hospital. Substantial progress has been made in its implementation in many developing countries where facility-based KMC has been institutionalized. Despite the cost-effectiveness of KMC in neonatal care, its global implementation is bedeviled with country-specific, multifaceted challenges. In developed countries, there is an implementation gap due to easy accessibility to technology-based CMC. Nevertheless, many developing countries have initiated national policies to scale up KMC services in their domain. Given the major constraints to program implementation peculiar to these resource-limited countries, it has become imperative to boost caregiver confidence and experience using dedicated spaces in the hospital, as well as dedicated staff meant for adequate ambulatory follow-up and continuous health education. Capacity training for health professionals and provision of space infrastructure thus constitute the basic needs which could be funded by International Aid Agencies in order to scale up the program in these settings. Keywords: neonatal care, low birth weight infants, thermoregulation, breastfeeding

  15. Initial investigation into lower-cost CT for resource limited regions of the world

    Science.gov (United States)

    Dobbins, James T., III; Wells, Jered R.; Segars, W. Paul; Li, Christina M.; Kigongo, Christopher J. N.

    2010-04-01

    This paper describes an initial investigation into means for producing lower-cost CT scanners for resource limited regions of the world. In regions such as sub-Saharan Africa, intermediate level medical facilities serving millions have no CT machines, and lack the imaging resources necessary to determine whether certain patients would benefit from being transferred to a hospital in a larger city for further diagnostic workup or treatment. Low-cost CT scanners would potentially be of immense help to the healthcare system in such regions. Such scanners would not produce state-of-theart image quality, but rather would be intended primarily for triaging purposes to determine the patients who would benefit from transfer to larger hospitals. The lower-cost scanner investigated here consists of a fixed digital radiography system and a rotating patient stage. This paper describes initial experiments to determine if such a configuration is feasible. Experiments were conducted using (1) x-ray image acquisition, a physical anthropomorphic chest phantom, and a flat-panel detector system, and (2) a computer-simulated XCAT chest phantom. Both the physical phantom and simulated phantom produced excellent image quality reconstructions when the phantom was perfectly aligned during acquisition, but artifacts were noted when the phantom was displaced to simulate patient motion. An algorithm was developed to correct for motion of the phantom and demonstrated success in correcting for 5-mm motion during 360-degree acquisition of images. These experiments demonstrated feasibility for this approach, but additional work is required to determine the exact limitations produced by patient motion.

  16. The high mass frontier: limits on heavy neutrinos

    International Nuclear Information System (INIS)

    Gronau, M.

    1984-01-01

    The theoretical motivation for a search for heavy neutrinos is discussed followed by the presentation of typical model dependent expectations for the mixing of the latter with ordinary neutrinos. Present mass and mixing limits on such heavy neutral leptons are based on search for secondary peaks in π and K leptonic decays and on the absence of neutrino decay signatures in neutrino beams from conventional sources and beam dumps. While these limits are quite poor for masses above 1 GeV, we describe methods to extend the limits to masses in the many GeV region. Such limits may be derived from search in b decays, high statistics neutrino experiments, search in ep colliders, W and Z decays and finally - decays of very heavy gauge bosons (if such exist in the TeV region) when produced in multi-TeV pp and antipp colliders

  17. High temperature performance limit of containment system of transport cask

    International Nuclear Information System (INIS)

    Kato, Osamu; Saegusa, Toshiari

    1998-01-01

    The containment performance of a containment system using elastomer gaskets for transport casks under a high temperature and high pressure was clarified. Major results are as follows; (1) The deformation characteristics of the gaskets were represented by the compressive permanent strain rate (Dp). The temperature and time dependence was shown by Larson-Miller Parameter (LMP). (2) Generally, the high temperature performance limit is obtained by a value of LMP when the Dp value reaches 80%. However, the gaskets (FKM, VMQ, EPDM) used for real transport casks were not damaged and the containment performance was not deteriorated as a conservative condition. (3) Assuming that the service period of the gaskets for transport casks is 3 months or 1 year, the high temperature performance limit of the gasket made of fluorine rubber (FKM) is 202degC or 182degC, respectively, which includes safety margin. (author)

  18. Transmission Level High Temperature Superconducting Fault Current Limiter

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Gary [SuperPower, Inc., Schenectady, NY (United States)

    2016-10-05

    The primary objective of this project was to demonstrate the feasibility and reliability of utilizing high-temperature superconducting (HTS) materials in a Transmission Level Superconducting Fault Current Limiter (SFCL) application. During the project, the type of high-temperature superconducting material used evolved from 1st generation (1G) BSCCO-2212 melt cast bulk high-temperature superconductors to 2nd generation (2G) YBCO-based high-temperature superconducting tape. The SFCL employed SuperPower's “Matrix” technology, that offers modular features to enable scale up to transmission voltage levels. The SFCL consists of individual modules that contain elements and parallel inductors that assist in carrying the current during the fault. A number of these modules are arranged in an m x n array to form the current-limiting matrix.

  19. High performance discharges near the operational limit in HT-7

    International Nuclear Information System (INIS)

    Li Jiangang; Wan Baonian; Luo Jiarong; Gao Xiang; Zhao Yanping; Kuang Guangli; Zhang Xiaodong; Yang Yu; Yi Bao; Bojiang Ding; Jikang Xie; Yuanxi Wan

    2001-01-01

    Efforts have been made on the HT-7 tokamak to extend the stable operation boundaries. Extensive RF boronization and siliconization have been used and a wider operational Hugill diagram has been obtained. The transit density reached 1.3 times the Greenwald density limit in ohmic discharges. A stationary high performance discharge with q a =2.1 has been obtained after siliconization. Confinement improvement was obtained as a result of the significant reduction of electron thermal diffusivity χ e in the outer region of the plasma. An improved confinement phase was also observed with LHCD in the density range of 70-120% of the Greenwald density limit. Off-axis LH wave power deposition was attributed to the weak hollow current density profile. Code simulations and measurements showed good agreement with the off-axis LH wave deposition. Supersonic molecular beam injection has been successfully used to achieve stable high density operation in the region of the Greenwald density limit. (author)

  20. Modular Laboratories—Cost-Effective and Sustainable Infrastructure for Resource-Limited Settings

    Science.gov (United States)

    Bridges, Daniel J.; Colborn, James; Chan, Adeline S. T.; Winters, Anna M.; Dengala, Dereje; Fornadel, Christen M.; Kosloff, Barry

    2014-01-01

    High-quality laboratory space to support basic science, clinical research projects, or health services is often severely lacking in the developing world. Moreover, the construction of suitable facilities using traditional methods is time-consuming, expensive, and challenging to implement. Three real world examples showing how shipping containers can be converted into modern laboratories are highlighted. These include use as an insectary, a molecular laboratory, and a BSL-3 containment laboratory. These modular conversions have a number of advantages over brick and mortar construction and provide a cost-effective and timely solution to offer high-quality, user-friendly laboratory space applicable within the developing world. PMID:25223943

  1. WHAT DRIVES HIGH COST OF FINANCE IN MOLDOVA?

    Directory of Open Access Journals (Sweden)

    Alexandru Stratan

    2012-03-01

    Full Text Available Why there are high costs to finance in Republic of Moldova? Is it a problem for business environment?These are the questions discussed in this paper. Following the well know Growth Diagnostics approach byHausmann, Rodrik and Velasco, authors assess the barriers and impediments to access to finance in Republic ofMoldova. Guided by international and national statistics we found evidence of poor intermediation, poorinstitutions, high level of inflation, and high collateral as major causes of high cost of financial resources inRepublic of Moldova. At the end of the study authors give policy recommendations identifying other related fieldsto be addressed.

  2. Radiance limits of ceramic phosphors under high excitation fluxes

    Science.gov (United States)

    Lenef, Alan; Kelso, John; Zheng, Yi; Tchoul, Maxim

    2013-09-01

    Ceramic phosphors, excited by high radiance pump sources, offer considerable potential for high radiance conversion. Interestingly, thermodynamic arguments suggest that the radiance of the luminescent spot can even exceed that of the incoming light source. In practice, however, thermal quenching and (non-thermal) optical saturation limit the maximum attainable radiance of the luminescent source. We present experimental data for Ce:YAG and Ce:GdYAG ceramics in which these limits have been investigated. High excitation fluxes are achieved using laser pumping. Optical pumping intensities exceeding 100W/mm2 have been shown to produce only modest efficiency depreciation at low overall pump powers because of the short Ce3+ lifetime, although additional limitations exist. When pump powers are higher, heat-transfer bottlenecks within the ceramic and heat-sink interfaces limit maximum pump intensities. We find that surface temperatures of these laser-pumped ceramics can reach well over 150°C, causing thermal-quenching losses. We also find that in some cases, the loss of quantum efficiency with increasing temperature can cause a thermal run-away effect, resulting in a rapid loss in converted light, possibly over-heating the sample or surrounding structures. While one can still obtain radiances on the order of many W/mm2/sr, temperature quenching effects ultimately limit converted light radiance. Finally, we use the diffusion-approximation radiation transport models and rate equation models to simulate some of these nonlinear optical pumping and heating effects in high-scattering ceramics.

  3. High-Efficient Low-Cost Photovoltaics Recent Developments

    CERN Document Server

    Petrova-Koch, Vesselinka; Goetzberger, Adolf

    2009-01-01

    A bird's-eye view of the development and problems of recent photovoltaic cells and systems and prospects for Si feedstock is presented. High-efficient low-cost PV modules, making use of novel efficient solar cells (based on c-Si or III-V materials), and low cost solar concentrators are in the focus of this book. Recent developments of organic photovoltaics, which is expected to overcome its difficulties and to enter the market soon, are also included.

  4. Distributed Flexibility Management Targeting Energy Cost and Total Power Limitations in Electricity Distribution Grids

    DEFF Research Database (Denmark)

    Bessler, Sanford; Kemal, Mohammed Seifu; Silva, Nuno

    2018-01-01

    Demand Management uses the interaction and information exchange between multiple control functions in order to achieve goals that can vary in different application contexts. Since there are several stakeholders involved, these may have diverse objectives and even use different architectures...... to actively manage power demand. This paper utilizes an existing distributed demand management architecture in order to provide the following contributions: (1) It develops and evaluates a set of algorithms that combine the optimization of energy costs in scenarios of variable day-ahead prices with the goal...... to improve distribution grid operation reliability, here implemented by a total Power limit. (2) It evaluates the proposed scheme as a distributed system where flexibility information is exchanged with the existing industry standard OpenADR. A Hardware-in-the-Loop testbed realization demonstrates...

  5. Resistive current limiter with high-temperature superconductors. Final report

    International Nuclear Information System (INIS)

    Schubert, M.

    1995-12-01

    Fundamental results of the possibility of using high temperature superconductors (HTSC) in resistive fault current limiters are discussed. Measurement of the homogeneity of BSCCO-powder-in-tube materials were made. In addition, investigations of the transition from superconducting to normalconducting state under AC-current conditions were carried out. Based on these results, simulations of HTSC-materials on ceramic substrate were made and recent results are presented. Important results of the investigations are: 1. Current-limiting without external trigger only possible when the critical current density of HTSC exceeds 10 4 A/cm 2 . 2. Inhomogeneities sometimes cause problems with local destruction. This can be solved by parallel-elements or external trigger. 3. Fast current-limiting causes overvoltages which can be reduced by using parallel-elements. (orig.) [de

  6. 42 CFR 447.206 - Cost limit for providers operated by units of government.

    Science.gov (United States)

    2010-10-01

    ... cost report (or Medicaid cost report for intermediate nursing facility care and ICFs/MR consistent with Medicare cost reporting principles, and audited financial statements that will be used in conjunction with...

  7. Power MOSFET-diode-based limiter for high-frequency ultrasound systems.

    Science.gov (United States)

    Choi, Hojong; Kim, Min Gon; Cummins, Thomas M; Hwang, Jae Youn; Shung, K Kirk

    2014-10-01

    The purpose of the limiter circuits used in the ultrasound imaging systems is to pass low-voltage echo signals generated by ultrasonic transducers while preventing high-voltage short pulses transmitted by pulsers from damaging front-end circuits. Resistor-diode-based limiters (a 50 Ω resistor with a single cross-coupled diode pair) have been widely used in pulse-echo measurement and imaging system applications due to their low cost and simple architecture. However, resistor-diode-based limiters may not be suited for high-frequency ultrasound transducer applications since they produce large signal conduction losses at higher frequencies. Therefore, we propose a new limiter architecture utilizing power MOSFETs, which we call a power MOSFET-diode-based limiter. The performance of a power MOSFET-diode-based limiter was evaluated with respect to insertion loss (IL), total harmonic distortion (THD), and response time (RT). We compared these results with those of three other conventional limiter designs and showed that the power MOSFET-diode-based limiter offers the lowest IL (-1.33 dB) and fastest RT (0.10 µs) with the lowest suppressed output voltage (3.47 Vp-p) among all the limiters at 70 MHz. A pulse-echo test was performed to determine how the new limiter affected the sensitivity and bandwidth of the transducer. We found that the sensitivity and bandwidth of the transducer were 130% and 129% greater, respectively, when combined with the new power MOSFET-diode-based limiter versus the resistor-diode-based limiter. Therefore, these results demonstrate that the power MOSFET-diode-based limiter is capable of producing lower signal attenuation than the three conventional limiter designs at higher frequency operation. © The Author(s) 2014.

  8. Limited applicability of cost-effectiveness and cost-benefit analyses for the optimization of radon remedial measures

    International Nuclear Information System (INIS)

    Jiránek, Martin; Rovenská, Kateřina

    2010-01-01

    Ways of using different decision-aiding techniques for optimizing and evaluating radon remedial measures have been studied on a large set of data obtained from the remediation of 32 houses that had an original indoor radon concentration level above 1,000 Bq/m 3 (around 0.2 % of all dwellings in the Czech Republic have a radon concentration higher than 1,000 Bq/ m 3 ). Detailed information about radon concentrations before and after remediation, type and extent of remedial measures and installation and operation costs were used as the input parameters for a comparison of costs and for determining the efficiencies, for a cost-benefit analysis and a cost-effectiveness analysis, in order to find out whether these criteria and techniques provide sufficient and relevant information for the improvement and optimization of remediation. The study has delivered quite new results. It is confirmed that the installation costs of remedial measures do not depend on the original level of indoor radon concentration, but on the technical state of the building. In addition, the study reveals that the efficiency of remediation does not depend on the installation costs. Each of the studied remedial measures will on an average save 0.3 lives and gain 4.3 years of life. On one hand, the general decision-aiding techniques - cost-benefit analysis and cost-effectiveness analysis - lead to the conclusion that the remedial measures reducing the indoor radon concentration from values above 1,000 Bq/m 3 to values below the action level of 400 Bq/m 3 are always acceptable and reasonable. On the other hand, these analytical techniques can neither help the designer to choose the proper remedial measure nor provide information resulting in improved remediation. (author)

  9. The Medicare Cost Report and the limits of hospital accountability: improving financial accounting data.

    Science.gov (United States)

    Kane, N M; Magnus, S A

    2001-02-01

    Health policy makers, legislators, providers, payers, and a broad range of other players in the health care market routinely seek information on hospital financial performance. Yet the data at their disposal are limited, especially since hospitals' audited financial statements--the "gold standard" in hospital financial reporting--are not publicly available in many states. As a result, the Medicare Cost Report (MCR), filed annually by most U.S. hospitals in order to receive payment for treating Medicare patients, has become the primary public source of hospital financial information. However, financial accounting elements in the MCR are unreliable, poorly defined, and lacking in critical detail. Comparative analyses of MCRs and matched, audited financial statements reveal long-standing problems with the MCR's data, including major differences in reported profits; variations in the reporting of both revenues and expenses; an absence of relevant details, such as charity care, bad debt, operating versus nonoperating income, and affiliate transactions; an inconsistent classification of changes in net assets; and a failure to provide cash flow statements. Because of these problems, MCR financial data give only a limited and often inaccurate picture of the financial position of hospitals. Audited financial statements provide a more complete perspective, enabling analysts to address important questions left unanswered by the MCR data. Regulatory action is needed to create a national database of financial information based upon audited statements.

  10. Intra- and Trans-Generational Costs of Reduced Female Body Size Caused by Food Limitation Early in Life in Mites

    OpenAIRE

    Walzer, Andreas; Schausberger, Peter

    2013-01-01

    Background Food limitation early in life may be compensated for by developmental plasticity resulting in accelerated development enhancing survival at the expense of small adult body size. However and especially for females in non-matching maternal and offspring environments, being smaller than the standard may incur considerable intra- and trans-generational costs. Methodology/Principal Findings Here, we evaluated the costs of small female body size induced by food limitation early in life i...

  11. Stringy symmetries and their high-energy limits

    International Nuclear Information System (INIS)

    Chan, C.-T.; Lee, J.-C.

    2005-01-01

    We derive stringy symmetries with conserved charges of arbitrarily high spins from the decoupling of two types of zero-norm states in the old covariant first quantized (OCFQ) spectrum of open bosonic string. These symmetries are valid to all energy α ' and all loop orders χ in string perturbation theory. The high-energy limit α ' ->∞ of these stringy symmetries can then be used to fix the proportionality constants between scattering amplitudes of different string states algebraically without referring to Gross and Mende's saddle point calculation of high-energy string-loop amplitudes. These proportionality constants are, as conjectured by Gross, independent of the scattering angle φ CM and the order χ of string perturbation theory. However, we also discover some new nonzero components of high-energy amplitudes not found previously by Gross and Manes. These components are essential to preserve massive gauge invariances or decouple massive zero-norm states of string theory. A set of massive scattering amplitudes and their high energy limit are calculated explicitly to justify our results

  12. Cost/benefit of high technology in diagnostic radiology

    Energy Technology Data Exchange (ETDEWEB)

    Goethlin, J.H.

    1987-08-01

    High technology is frequently blamed as a main cause for the last decade's disproportionate rise in health expenditure. Total costs for all large diagnostic and therapeutic appliances are typically less than 1% of annual expenditure on health care. CT, DSA, MRI, interventional radiology, ESWL, US, mammography, computers in radiology and PACS may save 10-80% of total cost for diagnosis and treatment of disease. Expenditure on high technology is in general vastly overestimated. Because of its medical utility, a slower deployment cannot be desirable. (orig.)

  13. Cost/benefit of high technology in diagnostic radiology

    International Nuclear Information System (INIS)

    Goethlin, J.H.

    1987-01-01

    High technology is frequently blamed as a main cause for the last decade's disproportionate rise in health expenditure. Total costs for all large diagnostic and therapeutic appliances are typically less than 1% of annual expenditure on health care. CT, DSA, MRI, interventional radiology, ESWL, US, mammography, computers in radiology and PACS may save 10-80% of total cost for diagnosis and treatment of disease. Expenditure on high technology is in general vastly overestimated. Because of its medical utility, a slower deployment cannot be desirable. (orig.)

  14. Modular laboratories--cost-effective and sustainable infrastructure for resource-limited settings.

    Science.gov (United States)

    Bridges, Daniel J; Colborn, James; Chan, Adeline S T; Winters, Anna M; Dengala, Dereje; Fornadel, Christen M; Kosloff, Barry

    2014-12-01

    High-quality laboratory space to support basic science, clinical research projects, or health services is often severely lacking in the developing world. Moreover, the construction of suitable facilities using traditional methods is time-consuming, expensive, and challenging to implement. Three real world examples showing how shipping containers can be converted into modern laboratories are highlighted. These include use as an insectary, a molecular laboratory, and a BSL-3 containment laboratory. These modular conversions have a number of advantages over brick and mortar construction and provide a cost-effective and timely solution to offer high-quality, user-friendly laboratory space applicable within the developing world. © The American Society of Tropical Medicine and Hygiene.

  15. CLASSICAL CALCULATION METHODS OF COSTS AND THEIR LIMITS IN ACTUAL FRAME OF ROMANIAN ECONOMY. PRESENT TENDENCIES IN COSTS ACCOUNTANCY

    Directory of Open Access Journals (Sweden)

    Simona Dragomirescu

    2008-12-01

    Full Text Available Classical accountancy shaped and coagulated in an informational system grafted on traditional production systems, characterized by mass productions, planning etc. The powerful concentrations and grouping, economies globalization, both as offer and as demand, the new restrictions and economical opportunities and global environment technologies lead to a redefining of enterprises’ objectives. From the well-known “quantity and productivity”, the enterprise faced a new system of objectives: quality’s increase; terms and costs decrease; productivity; flexibility. In such conditions the need of “defining new methods” appeared, the need of adapting the fundamental calculation methods, their improvement – respective the appearance of modern methods of costs calculation.

  16. Repository emplacement costs for Al-clad high enriched uranium spent fuel

    International Nuclear Information System (INIS)

    McDonell, W.R.; Parks, P.B.

    1994-01-01

    A range of strategies for treatment and packaging of Al-clad high-enriched uranium (HEU) spent fuels to prevent or delay the onset of criticality in a geologic repository was evaluated in terms of the number of canisters produced and associated repository costs incurred. The results indicated that strategies in which neutron poisons were added to consolidated forms of the U-Al alloy fuel generally produced the lowest number of canisters and associated repository costs. Chemical processing whereby the HEU was removed from the waste form was also a low cost option. The repository costs generally increased for isotopic dilution strategies, because of the substantial depleted uranium added. Chemical dissolution strategies without HEU removal were also penalized because of the inert constituents in the final waste glass form. Avoiding repository criticality by limiting the fissile mass content of each canister incurred the highest repository costs

  17. Surfaces for high heat dissipation with no Leidenfrost limit

    Science.gov (United States)

    Sajadi, Seyed Mohammad; Irajizad, Peyman; Kashyap, Varun; Farokhnia, Nazanin; Ghasemi, Hadi

    2017-07-01

    Heat dissipation from hot surfaces through cooling droplets is limited by the Leidenfrost point (LFP), in which an insulating vapor film prevents direct contact between the cooling droplet and the hot surface. A range of approaches have been developed to raise this limit to higher temperatures, but the limit still exists. Recently, a surface architecture, decoupled hierarchical structure, was developed that allows the suppression of LFP completely. However, heat dissipation by the structure in the low superheat region was inferior to other surfaces and the structure required an extensive micro/nano fabrication procedure. Here, we present a metallic surface structure with no LFP and high heat dissipation capacity in all temperature ranges. The surface features the nucleate boiling phenomenon independent of the temperature with an approximate heat transfer coefficient of 20 kW m-2 K-1. This surface is developed in a one-step process with no micro/nano fabrication. We envision that this metallic surface provides a unique platform for high heat dissipation in power generation, photonics/electronics, and aviation systems.

  18. Potential and Limitations of Low-Cost Unmanned Aerial Systems for Monitoring Altitudinal Vegetation Phenology in the Tropics

    Science.gov (United States)

    Silva, T. S. F.; Torres, R. S.; Morellato, P.

    2017-12-01

    Vegetation phenology is a key component of ecosystem function and biogeochemical cycling, and highly susceptible to climatic change. Phenological knowledge in the tropics is limited by lack of monitoring, traditionally done by laborious direct observation. Ground-based digital cameras can automate daily observations, but also offer limited spatial coverage. Imaging by low-cost Unmanned Aerial Systems (UAS) combines the fine resolution of ground-based methods with and unprecedented capability for spatial coverage, but challenges remain in producing color-consistent multitemporal images. We evaluated the applicability of multitemporal UAS imaging to monitor phenology in tropical altitudinal grasslands and forests, answering: 1) Can very-high resolution aerial photography from conventional digital cameras be used to reliably monitor vegetative and reproductive phenology? 2) How is UAS monitoring affected by changes in illumination and by sensor physical limitations? We flew imaging missions monthly from Feb-16 to Feb-17, using a UAS equipped with an RGB Canon SX260 camera. Flights were carried between 10am and 4pm, at 120-150m a.g.l., yielding 5-10cm spatial resolution. To compensate illumination changes caused by time of day, season and cloud cover, calibration was attempted using reference targets and empirical models, as well as color space transformations. For vegetative phenological monitoring, multitemporal response was severely affected by changes in illumination conditions, strongly confounding the phenological signal. These variations could not be adequately corrected through calibration due to sensor limitations. For reproductive phenology, the very-high resolution of the acquired imagery allowed discrimination of individual reproductive structures for some species, and its stark colorimetric differences to vegetative structures allowed detection of the reproductive timing on the HSV color space, despite illumination effects. We conclude that reliable

  19. Payer decision-making with limited comparative and cost effectiveness data: the case of new pharmacological treatments for gout.

    Science.gov (United States)

    Meltzer, Michele; Pizzi, Laura T; Jutkowitz, Eric

    2012-08-01

    The need for comparative effectiveness (CE) data continues to grow, fuelled by market demand as well as health reform. There may be an assumption that new drugs result in improved efficacy compared with the standard of care, therefore warranting premium prices. Gout treatment has recently become controversial, as expensive new drugs enter the market with limited CE data. The authors reviewed published clinical trials and conducted a cost effectiveness analysis on a new drug (febuxostat) versus the standard (allopurinol) to illustrate the limitations in using these data to inform evidence-based decision-making. Although febuxostat trials included allopurinol as a comparator, methodological limitations make comparative effectiveness evaluations difficult. However, when available trial data were input to a decision analytic model, the authors found that a significant reduction in febuxostat cost would be required in order for it to dominate allopurinol in cost effectiveness analysis. This case exemplifies the challenges of using clinical trial data in comparative and cost effectiveness analyses.

  20. The high cost of low-acuity ICU outliers.

    Science.gov (United States)

    Dahl, Deborah; Wojtal, Greg G; Breslow, Michael J; Holl, Randy; Huguez, Debra; Stone, David; Korpi, Gloria

    2012-01-01

    Direct variable costs were determined on each hospital day for all patients with an intensive care unit (ICU) stay in four Phoenix-area hospital ICUs. Average daily direct variable cost in the four ICUs ranged from $1,436 to $1,759 and represented 69.4 percent and 45.7 percent of total hospital stay cost for medical and surgical patients, respectively. Daily ICU cost and length of stay (LOS) were higher in patients with higher ICU admission acuity of illness as measured by the APACHE risk prediction methodology; 16.2 percent of patients had an ICU stay in excess of six days, and these LOS outliers accounted for 56.7 percent of total ICU cost. While higher-acuity patients were more likely to be ICU LOS outliers, 11.1 percent of low-risk patients were outliers. The low-risk group included 69.4 percent of the ICU population and accounted for 47 percent of all LOS outliers. Low-risk LOS outliers accounted for 25.3 percent of ICU cost and incurred fivefold higher hospital stay costs and mortality rates. These data suggest that severity of illness is an important determinant of daily resource consumption and LOS, regardless of whether the patient arrives in the ICU with high acuity or develops complications that increase acuity. The finding that a substantial number of long-stay patients come into the ICU with low acuity and deteriorate after ICU admission is not widely recognized and represents an important opportunity to improve patient outcomes and lower costs. ICUs should consider adding low-risk LOS data to their quality and financial performance reports.

  1. An analysis of factors affecting participation behavior of limited resource farmers in agricultural cost-share programs in Alabama

    Science.gov (United States)

    Okwudili Onianwa; Gerald Wheelock; Buddhi Gyawali; Jianbang Gan; Mark Dubois; John Schelhas

    2004-01-01

    This study examines factors that affect the participation behavior of limited resource farmers in agricultural cost-share programs in Alabama. The data were generated from a survey administered to a sample of limited resource farm operators. A binary logit model was employed to analyze the data. Results indicate that college education, age, gross sales, ratio of owned...

  2. Low Cost Lithography Tool for High Brightness LED Manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Andrew Hawryluk; Emily True

    2012-06-30

    The objective of this activity was to address the need for improved manufacturing tools for LEDs. Improvements include lower cost (both capital equipment cost reductions and cost-ofownership reductions), better automation and better yields. To meet the DOE objective of $1- 2/kilolumen, it will be necessary to develop these highly automated manufacturing tools. Lithography is used extensively in the fabrication of high-brightness LEDs, but the tools used to date are not scalable to high-volume manufacturing. This activity addressed the LED lithography process. During R&D and low volume manufacturing, most LED companies use contact-printers. However, several industries have shown that these printers are incompatible with high volume manufacturing and the LED industry needs to evolve to projection steppers. The need for projection lithography tools for LED manufacturing is identified in the Solid State Lighting Manufacturing Roadmap Draft, June 2009. The Roadmap states that Projection tools are needed by 2011. This work will modify a stepper, originally designed for semiconductor manufacturing, for use in LED manufacturing. This work addresses improvements to yield, material handling, automation and throughput for LED manufacturing while reducing the capital equipment cost.

  3. A high-performance, low-cost, leading edge discriminator

    Indian Academy of Sciences (India)

    Abstract. A high-performance, low-cost, leading edge discriminator has been designed with a timing performance comparable to state-of-the-art, commercially available discrim- inators. A timing error of 16 ps is achieved under ideal operating conditions. Under more realistic operating conditions the discriminator displays a ...

  4. The Cost of SOx Limits to Marine Operators; Results from Exploring Marine Fuel Prices

    Directory of Open Access Journals (Sweden)

    Orestis Schinas

    2013-06-01

    Full Text Available Marine operators are confronted with the new air emissions regulations that determine the limits of sulfur content in marine fuels. The low-sulfur (LS marine fuels have a higher price, and their fluctuation is almost similar to the fluctuation of high-sulfur (HS fuels. The price difference between HS and LS might also determine the decision of operators for alternative technical means, such as scrubbers, in order to comply with the new limits. This paper aims to provide a thorough statistical analysis of the currently available LS and HS marine fuels time series, as well as to present the analysis of the differential of the HS and LS fuel prices. The paper concludes with suggestions for further research.

  5. Black hole emission process in the high energy limit

    Energy Technology Data Exchange (ETDEWEB)

    Carter, B [Observatoire de Paris, Section de Meudon, 92 (France). Groupe d' Astrophysique Relativiste; Gibbons, G W; Lin, D N.C.; Perry, M J [Cambridge Univ. (UK). Dept. of Applied Mathematics and Theoretical Physics; Cambridge Univ. (UK). Inst. of Astronomy)

    1976-11-01

    The ultimate outcome of the Hawking process of particle emission by small black holes is discussed in terms of the various conceivable theories of the behaviour of matter in the ultra-high temperature limit. It is shown that if high temperature matter is described by a relatively hard equation of state with an adiabatic index GAMMA greater than 6/5 then interactions between particles can probably be ignored so that the rate of creation will continue to be describable by Hawking's method. On the other hand for softer equations of state (including those of the ultra soft Hagedorn type) the created matter will almost certainly be highly opaque and a hydrodynamic model of the emission process will be more appropriate. Actual astronomical detection of the final emission products might in principle have provided valuable information about the correct theory of ultra high energy physics but it is shown that in practice the black hole death rate is so low that observational distinction of the resulting high energy decay products from the background would require high resolution detectors.

  6. Command vector memory systems: high performance at low cost

    OpenAIRE

    Corbal San Adrián, Jesús; Espasa Sans, Roger; Valero Cortés, Mateo

    1998-01-01

    The focus of this paper is on designing both a low cost and high performance, high bandwidth vector memory system that takes advantage of modern commodity SDRAM memory chips. To successfully extract the full bandwidth from SDRAM parts, we propose a new memory system organization based on sending commands to the memory system as opposed to sending individual addresses. A command specifies, in a few bytes, a request for multiple independent memory words. A command is similar to a burst found in...

  7. Limitations of acceptability curves for presenting uncertainty in cost-effectiveness analysis

    NARCIS (Netherlands)

    Groot Koerkamp, Bas; Hunink, M. G. Myriam; Stijnen, Theo; Hammitt, James K.; Kuntz, Karen M.; Weinstein, Milton C.

    2007-01-01

    Clinical journals increasingly illustrate uncertainty about the cost and effect of health care interventions using cost-effectiveness acceptability curves (CEACs). CEACs present the probability that each competing alternative is optimal for a range of values of the cost-effectiveness threshold. The

  8. Capacitor performance limitations in high power converter applications

    DEFF Research Database (Denmark)

    El-Khatib, Walid Ziad; Holbøll, Joachim; Rasmussen, Tonny Wederberg

    2013-01-01

    High voltage low inductance capacitors are used in converters as HVDC-links, snubber circuits and sub model (MMC) capacitances. They facilitate the possibility of large peak currents under high frequent or transient voltage applications. On the other hand, using capacitors with larger equivalent...... series inductances include the risk of transient overvoltages, with a negative effect on life time and reliability of the capacitors. These allowable limits of such current and voltage peaks are decided by the ability of the converter components, including the capacitors, to withstand them over...... the expected life time. In this paper results are described from investigations on the electrical environment of these capacitors, including all the conditions they would be exposed to, thereby trying to find the tradeoffs needed to find a suitable capacitor. Different types of capacitors with the same voltage...

  9. High costs of female choice in a lekking lizard.

    Directory of Open Access Journals (Sweden)

    Maren N Vitousek

    2007-06-01

    Full Text Available Although the cost of mate choice is an essential component of the evolution and maintenance of sexual selection, the energetic cost of female choice has not previously been assessed directly. Here we report that females can incur high energetic costs as a result of discriminating among potential mates. We used heart rate biologging to quantify energetic expenditure in lek-mating female Galápagos marine iguanas (Amblyrhynchus cristatus. Receptive females spent 78.9+/-23.2 kJ of energy on mate choice over a 30-day period, which is equivalent to approximately (3/4 of one day's energy budget. Females that spent more time on the territories of high-quality, high-activity males displayed greater energetic expenditure on mate choice, lost more mass, and showed a trend towards producing smaller follicles. Choosy females also appear to face a reduced probability of survival if El Niño conditions occur in the year following breeding. These findings indicate that female choice can carry significant costs, and suggest that the benefits that lek-mating females gain through mating with a preferred male may be higher than previously predicted.

  10. Superconducting fault current limiter using high-resistive YBCO tapes

    Energy Technology Data Exchange (ETDEWEB)

    Yazawa, T. [Power and Industrial System R and D Center, Toshiba Corporation, 2-4 Suehiro, Tsurumi, Yokohama 230-0045 (Japan)], E-mail: takashi.yazawa@toshiba.co.jp; Koyanagi, K.; Takahashi, M.; Ono, M.; Toba, K.; Takigami, H.; Urata, M. [Power and Industrial System R and D Center, Toshiba Corporation, 2-4 Suehiro, Tsurumi, Yokohama 230-0045 (Japan); Iijima, Y.; Saito, T. [Fujikura Ltd., 1-5-1 Kiba, Koto, Tokyo 135-0042 (Japan); Ameniya, N. [Yokohama National University, 79-1 Tokiwadai, Hodogaya, Yokohama 240-8501 (Japan); Shiohara, Y. [Superconductivity Research Laboratory, ISTEC, 1-10-13 Shinonome, Koto, Tokyo 135-0062 (Japan)

    2008-09-15

    One of the programs in the Ministry of Economy and Trade and Industry (METI) project regarding R and D on YBCO conductor is to evaluate the applicability of the developed conductor toward several applications. This paper focuses on a fault current limiter (FCL) as one of the expected power applications. YBCO tape conductors with ion beam assisted deposition (IBAD) substrate are used in this work. In order to obtain high resistance of the conductor, which is preferable to an FCL, the thickness of the protecting layer made of silver was decreased as possible. Then high-resistive metal stabilizing layer is attached on the silver layer to improve stability. Obtaining the relevant current limiting performance on short sample experiments, model coils were developed to aim the 6.6 kV-class FCL. Short circuit experiments were implemented with a short circuit generator. The coil successfully restricted the short circuit current over 17 kA to about 700 A by the applied voltage of 3.8 kV, which is nominal phase-to-ground voltage. The experimental results show good agreement with computer analyses and show promising toward the application.

  11. Regulatory and cost barriers are likely to limit biosimilar development and expected savings in the near future.

    Science.gov (United States)

    Grabowski, Henry G; Guha, Rahul; Salgado, Maria

    2014-06-01

    In March 2010 Congress established an abbreviated Food and Drug Administration approval pathway for biosimilars-drugs that are very similar but not identical to a reference biological product and cost less. Because bringing biosimilars to the market currently requires large investments of money, fewer biosimilars are expected to enter the biologics market than has been the case with generic drugs entering the small-molecule drug market. Additionally, given the high regulatory hurdles to obtaining interchangeability-which would allow pharmacists to substitute a biosimilar for its reference product, subject to evolving state substitution laws-most biosimilars will likely compete as therapeutic alternatives instead of as therapeutic equivalents. In other words, biosimilars will need to compete with their reference product on the basis of quality; price; and manufacturer's reputation with physicians, insurers, and patient groups. Biosimilars also will face dynamic competition from new biologics in the same therapeutic class-including "biobetters," which offer incremental improvements on reference products, such as extended duration of action. The prospects for significant cost savings from the use of biosimilars appear to be limited for the next several years, but their use should increase over time because of both demand- and supply-side factors. Project HOPE—The People-to-People Health Foundation, Inc.

  12. Low cost, high yield IFE reactors: Revisiting Velikhov's vaporizing blankets

    International Nuclear Information System (INIS)

    Logan, B.G.

    1992-01-01

    The performance (efficiency and cost) of IFE reactors using MHD conversion is explored for target blanket shells of various materials vaporized and ionized by high fusion yields (5 to 500 GJ). A magnetized, prestressed reactor chamber concept is modeled together with previously developed models for the Compact Fusion Advanced Rankine II (CFARII) MHD Balance-of-Plant (BoP). Using conservative 1-D neutronics models, high fusion yields (20 to 80 GJ) are found necessary to heat Flibe, lithium, and lead-lithium blankets to MHD plasma temperatures, at initial solid thicknesses sufficient to capture most of the fusion yield. Advanced drivers/targets would need to be developed to achieve a ''Bang per Buck'' figure-of-merit approx-gt 20 to 40 joules yield per driver $ for this scheme to be competitive with these blanket materials. Alternatively, more realistic neutronics models and better materials such as lithium hydride may lower the minimum required yields substantially. The very low CFARII BoP costs (contributing only 3 mills/kWehr to CoE) allows this type of reactor, given sufficient advances that non-driver costs dominate, to ultimately produce electricity at a much lower cost than any current nuclear plant

  13. Highly integrated image sensors enable low-cost imaging systems

    Science.gov (United States)

    Gallagher, Paul K.; Lake, Don; Chalmers, David; Hurwitz, J. E. D.

    1997-09-01

    The highest barriers to wide scale implementation of vision systems have been cost. This is closely followed by the level of difficulty of putting a complete imaging system together. As anyone who has every been in the position of creating a vision system knows, the various bits and pieces supplied by the many vendors are not under any type of standardization control. In short, unless you are an expert in imaging, electrical interfacing, computers, digital signal processing, and high speed storage techniques, you will likely spend more money trying to do it yourself rather than to buy the exceedingly expensive systems available. Another alternative is making headway into the imaging market however. The growing investment in highly integrated CMOS based imagers is addressing both the cost and the system integration difficulties. This paper discusses the benefits gained from CMOS based imaging, and how these benefits are already being applied.

  14. Assessing the utility and limitations of high throughput virtual screening

    Directory of Open Access Journals (Sweden)

    Paul Daniel Phillips

    2016-05-01

    Full Text Available Due to low cost, speed, and unmatched ability to explore large numbers of compounds, high throughput virtual screening and molecular docking engines have become widely utilized by computational scientists. It is generally accepted that docking engines, such as AutoDock, produce reliable qualitative results for ligand-macromolecular receptor binding, and molecular docking results are commonly reported in literature in the absence of complementary wet lab experimental data. In this investigation, three variants of the sixteen amino acid peptide, α-conotoxin MII, were docked to a homology model of the a3β2-nicotinic acetylcholine receptor. DockoMatic version 2.0 was used to perform a virtual screen of each peptide ligand to the receptor for ten docking trials consisting of 100 AutoDock cycles per trial. The results were analyzed for both variation in the calculated binding energy obtained from AutoDock, and the orientation of bound peptide within the receptor. The results show that, while no clear correlation exists between consistent ligand binding pose and the calculated binding energy, AutoDock is able to determine a consistent positioning of bound peptide in the majority of trials when at least ten trials were evaluated.

  15. COST EFFECTIVE AND HIGH RESOLUTION SUBSURFACE CHARACTERIZATION USING HYDRAULIC TOMOGRAPHY

    Science.gov (United States)

    2017-08-01

    objective of this project is to provide the DoD and its remediation contractors with the HT technology for delineating the spatial distribution of...STATEMENT Approved for public release; distribution is unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Hydraulic Tomography ( HT ) is a high-resolution...performance of subsurface remedial actions at environmental sites. The good technical performance and cost-effectiveness of HT have been demonstrated in

  16. Patents Associated with High-Cost Drugs in Australia

    OpenAIRE

    Christie, Andrew F.; Dent, Chris; McIntyre, Peter; Wilson, Lachlan; Studdert, David M.

    2013-01-01

    Australia, like most countries, faces high and rapidly-rising drug costs. There are longstanding concerns about pharmaceutical companies inappropriately extending their monopoly position by "evergreening" blockbuster drugs, through misuse of the patent system. There is, however, very little empirical information about this behaviour. We fill the gap by analysing all of the patents associated with 15 of the costliest drugs in Australia over the last 20 years. Specifically, we search the patent...

  17. Limited fitness costs of herbicide-resistance traits in Amaranthus tuberculatus facilitate resistance evolution

    Science.gov (United States)

    The fitness cost of herbicide resistance (HR) in the absence of herbicide selection plays a key role in HR evolution. Quantifying the fitness cost of resistance, however, is challenging, and there exists a knowledge gap in this area. A synthetic Amaranthus tuberculatus population segregating for fiv...

  18. Oral nutritional support in malnourished elderly decreases functional limitations with no extra costs

    NARCIS (Netherlands)

    Neelemaat, Floor; Bosmans, Judith E; Thijs, Abel; Seidell, Jaap C; van Bokhorst-de van der Schueren, Marian A E

    2012-01-01

    BACKGROUND & AIMS: Older people are vulnerable to malnutrition which leads to increased health care costs. The aim of this study was to evaluate the cost-effectiveness of nutritional supplementation from a societal perspective. DESIGN: This randomized controlled trial included hospital admitted

  19. Norplant's high cost may prohibit use in Title 10 clinics.

    Science.gov (United States)

    1991-04-01

    The article discusses the prohibitive cost of Norplant for the Title 10 low-income population served in public family planning clinics in the U.S. It is argued that it's unfair for U.S. users to pay $350 to Wyeth- Ayerst when another pharmaceutical company provides developing countries with Norplant at a cost of $14 - 23. Although the public sector and private foundations funded the development, it was explained that the company needs to recoup the investment in training and education. Medicaid and third party payers such as insurance companies will reimburse for the higher price, but if the public sector price is lowered, then the company would not make a profit and everyone would have argued for the reimbursement at the lower cost. It was suggested that a boycott of American Home Products, Wyeth-Ayerst's parent company, be made. Public family planning providers who are particularly low in funding reflect that their budget of $30,000 would only provide 85 users, and identified in this circumstance by drug abusers and multiple pregnancy women, and the need for teenagers remains unfulfilled. Another remarked that the client population served is 4700 with $54,000 in funding, which is already accounted for. The general trend of comments was that for low income women the cost is to high.

  20. Removing Known SPS Intensity Limitations for High Luminosity LHC Goals

    CERN Document Server

    Shaposhnikova, Elena; Bohl, Thomas; Cruikshank, Paul; Goddard, Brennan; Kaltenbacher, Thomas; Lasheen, Alexandre; Perez Espinos, Jaime; Repond, Joël; Salvant, Benoit; Vollinger, Christine

    2016-01-01

    In preparation of the SPS as an LHC injector its impedance was significantly reduced in 1999 - 2000. A new SPS impedance reduction campaign is planned now for the High Luminosity (HL)-LHC project, which requires bunch intensities twice as high as the nominal one. One of the known intensity limitations is a longitudinal multi-bunch instability with a threshold 3 times below this operational intensity. The instability is presently cured using the 4th harmonic RF system and controlled emittance blow-up, but reaching the HL-LHC parameters cannot be assured without improving the machine impedance. Recently the impedance sources responsible for this instability were identified and implementation of their shielding and damping is foreseen during the next long shutdown (2019 - 2020) in synergy with two other important upgrades: amorphous carbon coating of (part of) the vacuum chamber against the e-cloud effect and rearrangement of the 200 MHz RF system. In this paper the strategy of impedance reduction is presented t...

  1. Analysis for the high-level waste disposal cost object

    International Nuclear Information System (INIS)

    Kim, S. K.; Lee, J. R.; Choi, J. W.; Han, P. S.

    2003-01-01

    The purpose of this study is to analyse the ratio of cost object in terms of the disposal cost estimation. According to the result, the ratio of operating cost is the most significant object in total cost. There are a lot of differences between the disposal costs and product costs in view of their constituents. While the product costs may be classified by the direct materials cost, direct manufacturing labor cost, and factory overhead the disposal cost factors should be constituted by the technical factors and the non-technical factors

  2. Cheap imports next ordeal for Europe's high-cost producers

    International Nuclear Information System (INIS)

    Chynoweth, E.

    1993-01-01

    About one-third of Europe's 34 cracker and downstream units lost money in the final quarter of 1992, says Chem Systems (London). Average return on capital employed is negative - at the same level as in the gloomy days of the early 1980s - yet average operating rates are 80% now, compared with 65% a decade ago. Margins at what Chem Systems calls leader cracks (naphtha-based units that use good modern practices) are DM42/m.t. ethylene, DM100/m.t. less than they were in 1991. The consultant firm's recent report, European Petrochemical Strategy in the 1990s, suggests closure of 5%-10% of high-cost production. But, Chem Systems director Roger Longley states: We are not advocating wholesale closure. There are a small number (of plants) where additional investment would not payback that would be economical to shut. Cost reduction through mergers and acquisitions and operational changes is much more important, especially from an international aspect, Longley says. One thing people do not fully appreciate is that Europe is a high-cost region for petrochemical production, he adds. Traditionally, Europe exports 5% of its ethylene output, now it needs to tolerate cheap imports

  3. Patents associated with high-cost drugs in Australia.

    Directory of Open Access Journals (Sweden)

    Andrew F Christie

    Full Text Available Australia, like most countries, faces high and rapidly-rising drug costs. There are longstanding concerns about pharmaceutical companies inappropriately extending their monopoly position by "evergreening" blockbuster drugs, through misuse of the patent system. There is, however, very little empirical information about this behaviour. We fill the gap by analysing all of the patents associated with 15 of the costliest drugs in Australia over the last 20 years. Specifically, we search the patent register to identify all the granted patents that cover the active pharmaceutical ingredient of the high-cost drugs. Then, we classify the patents by type, and identify their owners. We find a mean of 49 patents associated with each drug. Three-quarters of these patents are owned by companies other than the drug's originator. Surprisingly, the majority of all patents are owned by companies that do not have a record of developing top-selling drugs. Our findings show that a multitude of players seek monopoly control over innovations to blockbuster drugs. Consequently, attempts to control drug costs by mitigating misuse of the patent system are likely to miss the mark if they focus only on the patenting activities of originators.

  4. Patents associated with high-cost drugs in Australia.

    Science.gov (United States)

    Christie, Andrew F; Dent, Chris; McIntyre, Peter; Wilson, Lachlan; Studdert, David M

    2013-01-01

    Australia, like most countries, faces high and rapidly-rising drug costs. There are longstanding concerns about pharmaceutical companies inappropriately extending their monopoly position by "evergreening" blockbuster drugs, through misuse of the patent system. There is, however, very little empirical information about this behaviour. We fill the gap by analysing all of the patents associated with 15 of the costliest drugs in Australia over the last 20 years. Specifically, we search the patent register to identify all the granted patents that cover the active pharmaceutical ingredient of the high-cost drugs. Then, we classify the patents by type, and identify their owners. We find a mean of 49 patents associated with each drug. Three-quarters of these patents are owned by companies other than the drug's originator. Surprisingly, the majority of all patents are owned by companies that do not have a record of developing top-selling drugs. Our findings show that a multitude of players seek monopoly control over innovations to blockbuster drugs. Consequently, attempts to control drug costs by mitigating misuse of the patent system are likely to miss the mark if they focus only on the patenting activities of originators.

  5. The limitations of mathematical modeling in high school physics education

    Science.gov (United States)

    Forjan, Matej

    The theme of the doctoral dissertation falls within the scope of didactics of physics. Theoretical analysis of the key constraints that occur in the transmission of mathematical modeling of dynamical systems into field of physics education in secondary schools is presented. In an effort to explore the extent to which current physics education promotes understanding of models and modeling, we analyze the curriculum and the three most commonly used textbooks for high school physics. We focus primarily on the representation of the various stages of modeling in the solved tasks in textbooks and on the presentation of certain simplifications and idealizations, which are in high school physics frequently used. We show that one of the textbooks in most cases fairly and reasonably presents the simplifications, while the other two half of the analyzed simplifications do not explain. It also turns out that the vast majority of solved tasks in all the textbooks do not explicitly represent model assumptions based on what we can conclude that in high school physics the students do not develop sufficiently a sense of simplification and idealizations, which is a key part of the conceptual phase of modeling. For the introduction of modeling of dynamical systems the knowledge of students is also important, therefore we performed an empirical study on the extent to which high school students are able to understand the time evolution of some dynamical systems in the field of physics. The research results show the students have a very weak understanding of the dynamics of systems in which the feedbacks are present. This is independent of the year or final grade in physics and mathematics. When modeling dynamical systems in high school physics we also encounter the limitations which result from the lack of mathematical knowledge of students, because they don't know how analytically solve the differential equations. We show that when dealing with one-dimensional dynamical systems

  6. Cost modelling in maintenance strategy optimisation for infrastructure assets with limited data

    International Nuclear Information System (INIS)

    Zhang, Wenjuan; Wang, Wenbin

    2014-01-01

    Our paper reports on the use of cost modelling in maintenance strategy optimisation for infrastructure assets. We present an original approach: the possibility of modelling even when the data and information usually required are not sufficient in quantity and quality. Our method makes use of subjective expert knowledge, and requires information gathered for only a small sample of assets to start with. Bayes linear methods are adopted to combine the subjective expert knowledge with the sample data to estimate the unknown model parameters of the cost model. When new information becomes available, Bayes linear methods also prove useful in updating these estimates. We use a case study from the rail industry to demonstrate our methods. The optimal maintenance strategy is obtained via simulation based on the estimated model parameters and the strategy with the least unit time cost is identified. When the optimal strategy is not followed due to insufficient funding, the future costs of recovering the degraded asset condition are estimated

  7. Gasoline Engine HCCI Combustion - Extending the high load limit

    Energy Technology Data Exchange (ETDEWEB)

    Dahl, Daniel

    2012-07-01

    There is an increasing global focus on reducing emissions of greenhouse gases. For the automotive industry this means reducing CO2 emissions of the vehicles manufactured, which is synonymous with reducing their fuel consumption or adapting them for using renewable fuels. This thesis is based on a project aimed at improving the efficiency of gasoline engines in the lower load/speed region. The focus was mainly on a combustion strategy called homogeneous charge compression ignition (HCCI), but also on homogeneous lean and stratified lean spark-ignited combustion. In contrast to traditional stoichiometric spark-ignited combustion, HCCI can operate with diluted mixtures, which leads to better cycle efficiency, smaller pumping losses and smaller heat losses. However, at relatively high loads, HCCI combustion becomes excessively rapid, generating in-cylinder pressure oscillations (ringing), which are perceived as noise by the human ear. The main objective of the project was to identify ways to avoid this ringing behaviour in order to increase the upper load limit of HCCI. This is vital to avoid the need for mode switches to spark-ignited combustion at higher loads and to operate the engine as much as possible in the more effective HCCI mode. The strategy for reducing ringing investigated most extensively in the project was charge stratification, achieved by injecting part of the fuel late in the compression stroke. Available literature on effects of this strategy gave conflicting indications, both positive and negative effects have been reported, depending on the type of fuel and engine used. It was soon found that the strategy is effective for reducing ringing, but with resulting increases of NOX emissions. Further, in order for the strategy to be effective, global air/fuel ratios must not be much leaner than stoichiometric. The increases in NOX emissions were countered by shifting the ratio towards stoichiometric using exhaust gas recirculation (EGR), allowing a three

  8. High Performance, Low Cost Hydrogen Generation from Renewable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Ayers, Katherine [Proton OnSite; Dalton, Luke [Proton OnSite; Roemer, Andy [Proton OnSite; Carter, Blake [Proton OnSite; Niedzwiecki, Mike [Proton OnSite; Manco, Judith [Proton OnSite; Anderson, Everett [Proton OnSite; Capuano, Chris [Proton OnSite; Wang, Chao-Yang [Penn State University; Zhao, Wei [Penn State University

    2014-02-05

    Renewable hydrogen from proton exchange membrane (PEM) electrolysis is gaining strong interest in Europe, especially in Germany where wind penetration is already at critical levels for grid stability. For this application as well as biogas conversion and vehicle fueling, megawatt (MW) scale electrolysis is required. Proton has established a technology roadmap to achieve the necessary cost reductions and manufacturing scale up to maintain U.S. competitiveness in these markets. This project represents a highly successful example of the potential for cost reduction in PEM electrolysis, and provides the initial stack design and manufacturing development for Proton’s MW scale product launch. The majority of the program focused on the bipolar assembly, from electrochemical modeling to subscale stack development through prototyping and manufacturing qualification for a large active area cell platform. Feasibility for an advanced membrane electrode assembly (MEA) with 50% reduction in catalyst loading was also demonstrated. Based on the progress in this program and other parallel efforts, H2A analysis shows the status of PEM electrolysis technology dropping below $3.50/kg production costs, exceeding the 2015 target.

  9. A cost of sexual attractiveness to high-fitness females.

    Directory of Open Access Journals (Sweden)

    Tristan A F Long

    2009-12-01

    Full Text Available Adaptive mate choice by females is an important component of sexual selection in many species. The evolutionary consequences of male mate preferences, however, have received relatively little study, especially in the context of sexual conflict, where males often harm their mates. Here, we describe a new and counterintuitive cost of sexual selection in species with both male mate preference and sexual conflict via antagonistic male persistence: male mate choice for high-fecundity females leads to a diminished rate of adaptive evolution by reducing the advantage to females of expressing beneficial genetic variation. We then use a Drosophila melanogaster model system to experimentally test the key prediction of this theoretical cost: that antagonistic male persistence is directed toward, and harms, intrinsically higher-fitness females more than it does intrinsically lower-fitness females. This asymmetry in male persistence causes the tails of the population's fitness distribution to regress towards the mean, thereby reducing the efficacy of natural selection. We conclude that adaptive male mate choice can lead to an important, yet unappreciated, cost of sex and sexual selection.

  10. Low cost photomultiplier high-voltage readout system

    International Nuclear Information System (INIS)

    Oxoby, G.J.; Kunz, P.F.

    1976-10-01

    The Large Aperture Solenoid Spectrometer (LASS) at Stanford Linear Accelerator Center (SLAC) requires monitoring over 300 voltages. This data is recorded on magnetic tapes along with the event data. It must also be displayed so that operators can easily monitor and adjust the voltages. A low-cost high-voltage readout system has been implemented to offer stand-alone digital readout capability as well as fast data transfer to a host computer. The system is flexible enough to permit use of a DVM or ADC and commercially available analogue multiplexers

  11. Limiting technologies for particle beams and high energy physics

    International Nuclear Information System (INIS)

    Panofsky, W.K.H.

    1985-07-01

    Since 1930 the energy of accelerators had grown by an order of magnitude roughly every 7 years. Like all exponential growths, be they human population, the size of computers, or anything else, this eventually will have to come to an end. When will this happen to the growth of the energy of particle accelerators and colliders. Fortunately, as the energy of accelerators has grown the cost per unit energy has decreased almost as fast as has the increase in energy. The result is that while the energy has increased so dramatically the cost per new installation has increased only by roughly an order of magnitude since the 1930's (corrected for inflation), while the number of accelerators operating at the frontier of the field has shrunk. As is shown in the by now familiar Livingston chart this dramatic decrease in cost has been achieved largely by a succession of new technologies, in addition to the more moderate gains in efficiency due to improved design, economies of scale, etc. We are therefore facing two questions: (1) Is there good reason scientifically to maintain the exponential growth, and (2) Are there new technologies in sight which promise continued decreases in unit costs. The answer to the first question is definitely yes; the answer to the second question is maybe

  12. Limited risk assessment and some cost/benefit considerations for greater confinement disposal compared to shallow land burial

    International Nuclear Information System (INIS)

    Hunter, P.H.; Lester, D.H.; Robertson, L.D.; Spaeth, M.E.; Stoddard, J.A.; Dickman, P.T.

    1984-09-01

    A limited risk assessment and some cost/benefit considerations of greater confinement disposal (GCD) compared to shallow land burial (SLB) are presented. This study is limited to an analysis of the postclosure phase of hypothetical GCD and SLB facilities. Selected release scenarios are used which bound the range of risks to a maximally exposed individual and a hypothetical population. Based on the scenario assessments, GCD had a significant risk advantage over SLB for normal exposure pathways at both humid and arid sites, particularly for the human intrusion scenario. Since GCD costs are somewhat higher than SLB, it is necessary to weigh the higher costs of GCD against the higher risks of SLB. In this regard, GCD should be pursued as an alternative to SLB for certain types of low-level waste, and as an alternative to processing for wastes requiring improved stabilization or higher integrity packaging to be compatible with SLB. There are two reasons for this conclusion. First, GCD might diminish public apprehension regarding the disposal of wastes perceived to be too hazardous for SLB. Second, GCD may be a relatively cost-effective alternative to various stabilization and packaging schemes required to meet 10 CFR 61 near-surface requirements as well as being a cost-effective alternative to deep geologic disposal. Radionuclide transport through the biosphere and resultant dose consequences were determined using the RADTRAN radionuclide transport code. 19 references, 4 figures, 5 tables

  13. Local Property Tax Limitations vs. School District Employee Pension Costs in Pennsylvania

    Science.gov (United States)

    Hartman, William T.; Shrom, Timothy J.

    2014-01-01

    In Pennsylvania as in many other states, employee pension costs are a significant source of financial pressure for school districts (Zeehandelaar and Northern 2013, Pennsylvania Public Employees' Retirement Commission 2013). In order to gain greater insight into the nature of Pennsylvania school districts' financial burden related to pension…

  14. Reducing health care costs - potential and limitations of local, a1 ...

    African Journals Online (AJOL)

    1990-08-04

    Aug 4, 1990 ... ambulatory and hospital curative care, both the quality and the cost-effectiveness of .... home-nursing in South Mrica. This activity could either ... has perverted the axiom that 'prevention is cheaper than cure'. This axiom is not ...

  15. Moving beyond a limited follow-up in cost-effectiveness analyses of behavioral interventions

    NARCIS (Netherlands)

    Prenger, Hendrikje Cornelia; Pieterse, Marcel E.; Braakman-Jansen, Louise Marie Antoinette; van der Palen, Jacobus Adrianus Maria; Christenhusz, Lieke C.A.; Seydel, E.R.

    2013-01-01

    Background Cost-effectiveness analyses of behavioral interventions typically use a dichotomous outcome criterion. However, achieving behavioral change is a complex process involving several steps towards a change in behavior. Delayed effects may occur after an intervention period ends, which can

  16. 78 FR 43203 - Federal Acquisition Regulation; Submission for OMB Review; Contract Funding-Limitation of Costs...

    Science.gov (United States)

    2013-07-19

    ... information collection would violate the fundamental purposes of the Paperwork Reduction Act because of the... notification typically involves an observation of the contractors accounting and financial reporting system... probable cost overruns carries with it a duty to maintain an accounting and financial reporting system...

  17. 24 CFR 248.157 - Voluntary sale of housing not in excess of Federal cost limit.

    Science.gov (United States)

    2010-04-01

    ... costs; (5) Receive a distribution equal to an 8 percent annual return on any actual cash investment made... by a priority purchaser seeking to make an offer during either 6-month priority purchaser marketing...-based nonprofit and the offer is submitted within the marketing period established in paragraph (c)(1...

  18. Low Cost DIY Lenses kit For High School Teaching

    Science.gov (United States)

    Thepnurat, Meechai; Saphet, Parinya; Tong-on, Anusorn

    2017-09-01

    A set of lenses was fabricated from a low cost materials in a DIY (Do it yourself) process. The purpose was to demonstrate to teachers and students in high schools how to construct lenses by themselves with the local available materials. The lenses could be applied in teaching Physics, about the nature of a lens such as focal length and light rays passing through lenses in either direction, employing a set of simple laser pointers. This instrumental kit was made from a transparent 2 mm thick of acrylic Perspex. It was cut into rectangular pieces with dimensions of 2x15 cm2 and bent into curved shape by a hot air blower on a cylindrical wooden rod with curvature radii of about 3-4.5 cm. Then a pair of these Perspex were formed into a hollow thick lenses with a base supporting platform, so that any appropriate liquids could be filled in. The focal length of the lens was measured from laser beam drawing on a paper. The refractive index, n (n) of a filling liquid could be calculated from the measured focal length (f). The kit was low cost and DIY but was greatly applicable for optics teaching in high school laboratory.

  19. Evaluation of high yielding soybean germplasm under water limitation.

    Science.gov (United States)

    Prince, Silvas J; Murphy, Mackensie; Mutava, Raymond N; Zhang, Zhengzhi; Nguyen, Na; Kim, Yoon Ha; Pathan, Safiullah M; Shannon, Grover J; Valliyodan, Babu; Nguyen, Henry T

    2016-05-01

    Limited information is available for soybean root traits and their plasticity under drought stress. To date, no studies have focused on examining diverse soybean germplasm for regulation of shoot and root response under water limited conditions across varying soil types. In this study, 17 genetically diverse soybean germplasm lines were selected to study root response to water limited conditions in clay (trial 1) and sandy soil (trial 2) in two target environments. Physiological data on shoot traits was measured at multiple crop stages ranging from early vegetative to pod filling. The phenotypic root traits, and biomass accumulation data are collected at pod filling stage. In trial 1, the number of lateral roots and forks were positively correlated with plot yield under water limitation and in trial 2, lateral root thickness was positively correlated with the hill plot yield. Plant Introduction (PI) 578477A and 088444 were found to have higher later root number and forks in clay soil with higher yield under water limitation. In sandy soil, PI458020 was found to have a thicker lateral root system and higher yield under water limitation. The genotypes identified in this study could be used to enhance drought tolerance of elite soybean cultivars through improved root traits specific to target environments. © 2015 Institute of Botany, Chinese Academy of Sciences.

  20. Cost-effectiveness of national health insurance programs in high-income countries: A systematic review.

    Directory of Open Access Journals (Sweden)

    Son Nghiem

    Full Text Available National health insurance is now common in most developed countries. This study reviews the evidence and synthesizes the cost-effectiveness information for national health insurance or disability insurance programs across high-income countries.A literature search using health, economics and systematic review electronic databases (PubMed, Embase, Medline, Econlit, RepEc, Cochrane library and Campbell library, was conducted from April to October 2015.Two reviewers independently selected relevant studies by applying screening criteria to the title and keywords fields, followed by a detailed examination of abstracts.Studies were selected for data extraction using a quality assessment form consisting of five questions. Only studies with positive answers to all five screening questions were selected for data extraction. Data were entered into a data extraction form by one reviewer and verified by another.Data on costs and quality of life in control and treatment groups were used to draw distributions for synthesis. We chose the log-normal distribution for both cost and quality-of-life data to reflect non-negative value and high skew. The results were synthesized using a Monte Carlo simulation, with 10,000 repetitions, to estimate the overall cost-effectiveness of national health insurance programs.Four studies from the United States that examined the cost-effectiveness of national health insurance were included in the review. One study examined the effects of medical expenditure, and the remaining studies examined the cost-effectiveness of health insurance reforms. The incremental cost-effectiveness ratio (ICER ranged from US$23,000 to US$64,000 per QALY. The combined results showed that national health insurance is associated with an average incremental cost-effectiveness ratio of US$51,300 per quality-adjusted life year (QALY. Based on the standard threshold for cost-effectiveness, national insurance programs are cost-effective interventions

  1. Segmentation of low‐cost high efficiency oxide‐based thermoelectric materials

    DEFF Research Database (Denmark)

    Le, Thanh Hung; Van Nong, Ngo; Linderoth, Søren

    2015-01-01

    Thermoelectric (TE) oxide materials have attracted great interest in advanced renewable energy research owing to the fact that they consist of abundant elements, can be manufactured by low-cost processing, sustain high temperatures, be robust and provide long lifetime. However, the low conversion...... efficiency of TE oxides has been a major drawback limiting these materials to broaden applications. In this work, theoretical calculations are used to predict how segmentation of oxide and semimetal materials, utilizing the benefits of both types of materials, can provide high efficiency, high temperature...... oxide-based segmented legs. The materials for segmentation are selected by their compatibility factors and their conversion efficiency versus material cost, i.e., “efficiency ratio”. Numerical modelling results showed that conversion efficiency could reach values of more than 10% for unicouples using...

  2. How do high cost-sharing policies for physician care affect total care costs among people with chronic disease?

    Science.gov (United States)

    Xin, Haichang; Harman, Jeffrey S; Yang, Zhou

    2014-01-01

    This study examines whether high cost-sharing in physician care is associated with a differential impact on total care costs by health status. Total care includes physician care, emergency room (ER) visits and inpatient care. Since high cost-sharing policies can reduce needed care as well as unneeded care use, it raises the concern whether these policies are a good strategy for controlling costs among chronically ill patients. This study used the 2007 Medical Expenditure Panel Survey data with a cross-sectional study design. Difference in difference (DID), instrumental variable technique, two-part model, and bootstrap technique were employed to analyze cost data. Chronically ill individuals' probability of reducing any overall care costs was significantly less than healthier individuals (beta = 2.18, p = 0.04), while the integrated DID estimator from split results indicated that going from low cost-sharing to high cost-sharing significantly reduced costs by $12,853.23 more for sick people than for healthy people (95% CI: -$17,582.86, -$8,123.60). This greater cost reduction in total care among sick people likely resulted from greater cost reduction in physician care, and may have come at the expense of jeopardizing health outcomes by depriving patients of needed care. Thus, these policies would be inappropriate in the short run, and unlikely in the long run to control health plans costs among chronically ill individuals. A generous benefit design with low cost-sharing policies in physician care or primary care is recommended for both health plans and chronically ill individuals, to save costs and protect these enrollees' health status.

  3. Evaluation of a Low-Cost Bubble CPAP System Designed for Resource-Limited Settings.

    Science.gov (United States)

    Bennett, Desmond J; Carroll, Ryan W; Kacmarek, Robert M

    2018-04-01

    Respiratory compromise is a leading contributor to global neonatal death. CPAP is a method of treatment that helps maintain lung volume during expiration, promotes comfortable breathing, and improves oxygenation. Bubble CPAP is an effective alternative to standard CPAP. We sought to determine the reliability and functionality of a low-cost bubble CPAP device designed for low-resource settings. The low-cost bubble CPAP device was compared to a commercially available bubble CPAP system. The devices were connected to a lung simulator that simulated neonates of 4 different weights with compromised respiratory mechanics (∼1, ∼3, ∼5, and ∼10 kg). The devices' abilities to establish and maintain pressure and flow under normal conditions as well as under conditions of leak were compared. Multiple combinations of pressure levels (5, 8, and 10 cm H 2 O) and flow levels (3, 6, and 10 L/min) were tested. The endurance of both devices was also tested by running the systems continuously for 8 h and measuring the changes in pressure and flow. Both devices performed equivalently during the no-leak and leak trials. While our testing revealed individual differences that were statistically significant and clinically important (>10% difference) within specific CPAP and flow-level settings, no overall comparisons of CPAP or flow were both statistically significant and clinically important. Each device delivered pressures similar to the desired pressures, although the flows delivered by both machines were lower than the set flows in most trials. During the endurance trials, the low-cost device was marginally better at maintaining pressure, while the commercially available device was better at maintaining flow. The low-cost bubble CPAP device evaluated in this study is comparable to a bubble CPAP system used in developed settings. Extensive clinical trials, however, are necessary to confirm its effectiveness. Copyright © 2018 by Daedalus Enterprises.

  4. High performance operational limits of tokamak and helical systems

    International Nuclear Information System (INIS)

    Yamazaki, Kozo; Kikuchi, Mitsuru

    2003-01-01

    The plasma operational boundaries of tokamak and helical systems are surveyed and compared with each other. Global confinement scaling laws are similar and gyro-Bohm like, however, local transport process is different due to sawtooth oscillations in tokamaks and ripple transport loss in helical systems. As for stability limits, achievable tokamak beta is explained by ideal or resistive MHD theories. On the other hand, beta values obtained so far in helical system are beyond ideal Mercier mode limits. Density limits in tokamak are often related to the coupling between radiation collapse and disruptive MHD instabilities, but the slow radiation collapse is dominant in the helical system. The pulse length of both tokamak and helical systems is on the order of hours in small machines, and the longer-pulsed good-confinement plasma operations compatible with radiative divertors are anticipated in both systems in the future. (author)

  5. Low-cost matched sibling bone marrow transplant for standard-risk thalassemia in a limited-resource setting

    Directory of Open Access Journals (Sweden)

    Stalin Ramprakash

    2017-12-01

    Full Text Available Thalassemias are the most common inherited genetic disorder in India and a major public health burden with bone marrow transplant (BMT considered the only established curative therapy. We describe outcomes for patients (n = 71 with standard-risk thalassemia (liver size 80 at the last follow up. 5 patients (7% died, mortality related to transplant. Enough data existed for 2 centers in India (36/71 transplants to analyze overall costs from admission up to one-year post-BMT which revealed a median cost of Rs 7,30,445 ($11519 [Range Rs 4,52,821–10,32,842 ($ 7079–16147]. In conclusion, children with thalassemia in resource limited settings can achieve good outcomes with BMT at a reasonable cost.

  6. The Cost-Effectiveness of High-Risk Lung Cancer Screening and Drivers of Program Efficiency.

    Science.gov (United States)

    Cressman, Sonya; Peacock, Stuart J; Tammemägi, Martin C; Evans, William K; Leighl, Natasha B; Goffin, John R; Tremblay, Alain; Liu, Geoffrey; Manos, Daria; MacEachern, Paul; Bhatia, Rick; Puksa, Serge; Nicholas, Garth; McWilliams, Annette; Mayo, John R; Yee, John; English, John C; Pataky, Reka; McPherson, Emily; Atkar-Khattra, Sukhinder; Johnston, Michael R; Schmidt, Heidi; Shepherd, Frances A; Soghrati, Kam; Amjadi, Kayvan; Burrowes, Paul; Couture, Christian; Sekhon, Harmanjatinder S; Yasufuku, Kazuhiro; Goss, Glenwood; Ionescu, Diana N; Hwang, David M; Martel, Simon; Sin, Don D; Tan, Wan C; Urbanski, Stefan; Xu, Zhaolin; Tsao, Ming-Sound; Lam, Stephen

    2017-08-01

    Lung cancer risk prediction models have the potential to make programs more affordable; however, the economic evidence is limited. Participants in the National Lung Cancer Screening Trial (NLST) were retrospectively identified with the risk prediction tool developed from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. The high-risk subgroup was assessed for lung cancer incidence and demographic characteristics compared with those in the low-risk subgroup and the Pan-Canadian Early Detection of Lung Cancer Study (PanCan), which is an observational study that was high-risk-selected in Canada. A comparison of high-risk screening versus standard care was made with a decision-analytic model using data from the NLST with Canadian cost data from screening and treatment in the PanCan study. Probabilistic and deterministic sensitivity analyses were undertaken to assess uncertainty and identify drivers of program efficiency. Use of the risk prediction tool developed from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial with a threshold set at 2% over 6 years would have reduced the number of individuals who needed to be screened in the NLST by 81%. High-risk screening participants in the NLST had more adverse demographic characteristics than their counterparts in the PanCan study. High-risk screening would cost $20,724 (in 2015 Canadian dollars) per quality-adjusted life-year gained and would be considered cost-effective at a willingness-to-pay threshold of $100,000 in Canadian dollars per quality-adjusted life-year gained with a probability of 0.62. Cost-effectiveness was driven primarily by non-lung cancer outcomes. Higher noncurative drug costs or current costs for immunotherapy and targeted therapies in the United States would render lung cancer screening a cost-saving intervention. Non-lung cancer outcomes drive screening efficiency in diverse, tobacco-exposed populations. Use of risk selection can reduce the budget impact, and

  7. High voltage fault current limiter having immersed phase coils

    Science.gov (United States)

    Darmann, Francis Anthony

    2014-04-22

    A fault current limiter including: a ferromagnetic circuit formed from a ferromagnetic material and including at least a first limb, and a second limb; a saturation mechanism surrounding a limb for magnetically saturating the ferromagnetic material; a phase coil wound around a second limb; a dielectric fluid surrounding the phase coil; a gaseous atmosphere surrounding the saturation mechanism.

  8. Nonlocal ultrafast magnetization dynamics in the high fluence limit

    NARCIS (Netherlands)

    Kuiper, K.C.; Malinowski, G.; Dalla Longa, F.; Koopmans, B.

    2011-01-01

    In order to explain a number of recent experimental observations of laser-induced femtosecond demagnetization in the large fluence limit, we discuss the consequences of a recently proposed nonlocal approach. A microscopic description of spin flip scattering is implemented in an effective three

  9. Is There a Limit to Growth? Comparing the Environmental Cost of an Airport’s Operations with Its Economic Benefit

    Directory of Open Access Journals (Sweden)

    Cherie Lu

    2017-11-01

    Full Text Available With the growing global awareness of the requirement for sustainable development, economic development is no longer the sole objective of business activities. The need to find a balance between environmental impacts and economic benefits is especially the case for airport operations in or around cities. This study measured the environmental costs and economic benefits and of an airport for a period of 10 years, using Taipei Songshan Airport for the empirical analysis, to examine whether the environmental costs could outweigh the economic benefits. Of all the environmental negative side effects, aircraft engine emissions and noise nuisance are considered the main sources of environmental impacts. The dose-response method and the hedonic price method, respectively, were used for estimating the social costs of these. Income generation from both direct and secondary employment is measured as economic benefits by applying the Garin-Lowry model, originally developed in 1966, for estimation of the employment multiplier. The results show that, in general, the operation of Taipei Songshan Airport brought more economic benefits than environmental costs. The sensitivity analysis of emissions and noise social cost parameters shows that the environmental costs might have exceeded the economic benefits in 2008 and 2009 in certain high emissions and noise social cost cases.

  10. When it is costly to have a caring mother: food limitation erases the benefits of parental care in earwigs

    OpenAIRE

    Meunier Joel; Koelliker Mathias

    2012-01-01

    The aggregation of parents with offspring is generally associated with different forms of care that improve offspring survival at potential costs to parents. Under poor environments, the limited amount of resources available can increase the level of competition among family members and consequently lead to adaptive changes in parental investment. However, it remains unclear as to what extent such changes modify offspring fitness, particularly when offspring can survive without parents such a...

  11. High Resolution Melting (HRM) for High-Throughput Genotyping—Limitations and Caveats in Practical Case Studies

    Science.gov (United States)

    Słomka, Marcin; Sobalska-Kwapis, Marta; Wachulec, Monika; Bartosz, Grzegorz

    2017-01-01

    High resolution melting (HRM) is a convenient method for gene scanning as well as genotyping of individual and multiple single nucleotide polymorphisms (SNPs). This rapid, simple, closed-tube, homogenous, and cost-efficient approach has the capacity for high specificity and sensitivity, while allowing easy transition to high-throughput scale. In this paper, we provide examples from our laboratory practice of some problematic issues which can affect the performance and data analysis of HRM results, especially with regard to reference curve-based targeted genotyping. We present those examples in order of the typical experimental workflow, and discuss the crucial significance of the respective experimental errors and limitations for the quality and analysis of results. The experimental details which have a decisive impact on correct execution of a HRM genotyping experiment include type and quality of DNA source material, reproducibility of isolation method and template DNA preparation, primer and amplicon design, automation-derived preparation and pipetting inconsistencies, as well as physical limitations in melting curve distinction for alternative variants and careful selection of samples for validation by sequencing. We provide a case-by-case analysis and discussion of actual problems we encountered and solutions that should be taken into account by researchers newly attempting HRM genotyping, especially in a high-throughput setup. PMID:29099791

  12. High Resolution Melting (HRM) for High-Throughput Genotyping-Limitations and Caveats in Practical Case Studies.

    Science.gov (United States)

    Słomka, Marcin; Sobalska-Kwapis, Marta; Wachulec, Monika; Bartosz, Grzegorz; Strapagiel, Dominik

    2017-11-03

    High resolution melting (HRM) is a convenient method for gene scanning as well as genotyping of individual and multiple single nucleotide polymorphisms (SNPs). This rapid, simple, closed-tube, homogenous, and cost-efficient approach has the capacity for high specificity and sensitivity, while allowing easy transition to high-throughput scale. In this paper, we provide examples from our laboratory practice of some problematic issues which can affect the performance and data analysis of HRM results, especially with regard to reference curve-based targeted genotyping. We present those examples in order of the typical experimental workflow, and discuss the crucial significance of the respective experimental errors and limitations for the quality and analysis of results. The experimental details which have a decisive impact on correct execution of a HRM genotyping experiment include type and quality of DNA source material, reproducibility of isolation method and template DNA preparation, primer and amplicon design, automation-derived preparation and pipetting inconsistencies, as well as physical limitations in melting curve distinction for alternative variants and careful selection of samples for validation by sequencing. We provide a case-by-case analysis and discussion of actual problems we encountered and solutions that should be taken into account by researchers newly attempting HRM genotyping, especially in a high-throughput setup.

  13. High Resolution Melting (HRM for High-Throughput Genotyping—Limitations and Caveats in Practical Case Studies

    Directory of Open Access Journals (Sweden)

    Marcin Słomka

    2017-11-01

    Full Text Available High resolution melting (HRM is a convenient method for gene scanning as well as genotyping of individual and multiple single nucleotide polymorphisms (SNPs. This rapid, simple, closed-tube, homogenous, and cost-efficient approach has the capacity for high specificity and sensitivity, while allowing easy transition to high-throughput scale. In this paper, we provide examples from our laboratory practice of some problematic issues which can affect the performance and data analysis of HRM results, especially with regard to reference curve-based targeted genotyping. We present those examples in order of the typical experimental workflow, and discuss the crucial significance of the respective experimental errors and limitations for the quality and analysis of results. The experimental details which have a decisive impact on correct execution of a HRM genotyping experiment include type and quality of DNA source material, reproducibility of isolation method and template DNA preparation, primer and amplicon design, automation-derived preparation and pipetting inconsistencies, as well as physical limitations in melting curve distinction for alternative variants and careful selection of samples for validation by sequencing. We provide a case-by-case analysis and discussion of actual problems we encountered and solutions that should be taken into account by researchers newly attempting HRM genotyping, especially in a high-throughput setup.

  14. Offshore compression system design for low cost high and reliability

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Carlos J. Rocha de O.; Carrijo Neto, Antonio Dias; Cordeiro, Alexandre Franca [Chemtech Engineering Services and Software Ltd., Rio de Janeiro, RJ (Brazil). Special Projects Div.], Emails: antonio.carrijo@chemtech.com.br, carlos.rocha@chemtech.com.br, alexandre.cordeiro@chemtech.com.br

    2010-07-01

    In the offshore oil fields, the oil streams coming from the wells usually have significant amounts of gas. This gas is separated at low pressure and has to be compressed to the export pipeline pressure, usually at high pressure to reduce the needed diameter of the pipelines. In the past, this gases where flared, but nowadays there are a increasing pressure for the energy efficiency improvement of the oil rigs and the use of this gaseous fraction. The most expensive equipment of this kind of plant are the compression and power generation systems, being the second a strong function of the first, because the most power consuming equipment are the compressors. For this reason, the optimization of the compression system in terms of efficiency and cost are determinant to the plant profit. The availability of the plants also have a strong influence in the plant profit, specially in gas fields where the products have a relatively low aggregated value, compared to oil. Due this, the third design variable of the compression system becomes the reliability. As high the reliability, larger will be the plant production. The main ways to improve the reliability of compression system are the use of multiple compression trains in parallel, in a 2x50% or 3x50% configuration, with one in stand-by. Such configurations are possible and have some advantages and disadvantages, but the main side effect is the increase of the cost. This is the offshore common practice, but that does not always significantly improve the plant availability, depending of the previous process system. A series arrangement and a critical evaluation of the overall system in some cases can provide a cheaper system with equal or better performance. This paper shows a case study of the procedure to evaluate a compression system design to improve the reliability but without extreme cost increase, balancing the number of equipment, the series or parallel arrangement, and the driver selection. Two cases studies will be

  15. Capital cost: high and low sulfur coal plants-1200 MWe. [High sulfur coal

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    This Commercial Electric Power Cost Study for 1200 MWe (Nominal) high and low sulfur coal plants consists of three volumes. The high sulfur coal plant is described in Volumes I and II, while Volume III describes the low sulfur coal plant. The design basis and cost estimate for the 1232 MWe high sulfur coal plant is presented in Volume I, and the drawings, equipment list and site description are contained in Volume II. The reference design includes a lime flue gas desulfurization system. A regenerative sulfur dioxide removal system using magnesium oxide is also presented as an alternate in Section 7 Volume II. The design basis, drawings and summary cost estimate for a 1243 MWe low sulfur coal plant are presented in Volume III. This information was developed by redesigning the high sulfur coal plant for burning low sulfur sub-bituminous coal. These coal plants utilize a mechanical draft (wet) cooling tower system for condenser heat removal. Costs of alternate cooling systems are provided in Report No. 7 in this series of studies of costs of commercial electrical power plants.

  16. Gaps between Jets in the high energy limit

    International Nuclear Information System (INIS)

    Forshaw, Jeffrey R.; Kyrieleis, Albrecht; Seymour, Michael H.

    2005-01-01

    We use perturbative QCD to calculate the parton level cross section for the production of two jets that are far apart in rapidity, subject to a limitation on the total transverse momentum Q 0 in the interjet region. We specifically address the question of how to combine the approach which sums all leading logarithms in Q/Q 0 (where Q is the jet transverse momentum) with the BFKL approach, in which leading logarithms of the scattering energy are summed. This paper constitutes progress towards the simultaneous summation of all important logarithms. Using an 'all orders' matching, we are able to obtain results for the cross section which correctly reproduce the two approaches in the appropriate limits

  17. The costs and cost-efficiency of providing food through schools in areas of high food insecurity.

    Science.gov (United States)

    Gelli, Aulo; Al-Shaiba, Najeeb; Espejo, Francisco

    2009-03-01

    The provision of food in and through schools has been used to support the education, health, and nutrition of school-aged children. The monitoring of financial inputs into school health and nutrition programs is critical for a number of reasons, including accountability, transparency, and equity. Furthermore, there is a gap in the evidence on the costs, cost-efficiency, and cost-effectiveness of providing food through schools, particularly in areas of high food insecurity. To estimate the programmatic costs and cost-efficiency associated with providing food through schools in food-insecure, developing-country contexts, by analyzing global project data from the World Food Programme (WFP). Project data, including expenditures and number of schoolchildren covered, were collected through project reports and validated through WFP Country Office records. Yearly project costs per schoolchild were standardized over a set number of feeding days and the amount of energy provided by the average ration. Output metrics, such as tonnage, calories, and micronutrient content, were used to assess the cost-efficiency of the different delivery mechanisms. The average yearly expenditure per child, standardized over a 200-day on-site feeding period and an average ration, excluding school-level costs, was US$21.59. The costs varied substantially according to choice of food modality, with fortified biscuits providing the least costly option of about US$11 per year and take-home rations providing the most expensive option at approximately US$52 per year. Comparisons across the different food modalities suggested that fortified biscuits provide the most cost-efficient option in terms of micronutrient delivery (particularly vitamin A and iodine), whereas on-site meals appear to be more efficient in terms of calories delivered. Transportation and logistics costs were the main drivers for the high costs. The choice of program objectives will to a large degree dictate the food modality

  18. Sources for high frequency heating. Performance and limitations

    International Nuclear Information System (INIS)

    Le Gardeur, R.

    1976-01-01

    The various problems encountered in high frequency heating of plasmas can be decomposed into three spheres of action: theoretical development, antenna designing, and utilization of power sources. By classifying heating into three spectral domains, present and future needs are enumerated. Several specific antenna designs are treated. High frequency power sources are reviewed. The actual development of the gyratron is discussed in view of future needs in very high frequency heating of plasmas [fr

  19. Limiting overselling in international emissions trading 1: Costs and environmental impacts of alternative proposals

    Energy Technology Data Exchange (ETDEWEB)

    Haites, E.; Missfeldt, F.

    2002-07-01

    Emission trading allows a country with an emission limitation commitment, an Annex B Party, to sell parts of its assigned amount (AAUs) to other Annex B Parties. If the seller subsequently does not have sufficient AAUs to cover its actual emissions it will be subject to the penalties for non-compliance. The revenue from the sale of AAUs may exceed the sanctions for non-compliance if these penalties are weak or difficult to enforce. Under these circumstances emission trading enables a country to benefit financially through non-compliance. Liability proposals seek to ensure that non-compliance is not rewarded, by limiting sales of AAUs to amounts surplus to the seller's compliance needs. This study develops and applies a model to assess the performance of different liability proposals. A simple model based on the Emissions Projection and Policy Analysis (EPPA) model of the Massachusetts Institute of Technology is used for the analysis. (BA)

  20. Growth limitation of Lemna minor due to high plant density

    NARCIS (Netherlands)

    Driever, S.M.; Nes, van E.H.; Roijackers, R.M.M.

    2005-01-01

    The effect of high population densities on the growth rate of Lemna minor (L.) was studied under laboratory conditions at 23°C in a medium with sufficient nutrients. At high population densities, we found a non-linear decreasing growth rate with increasing L. minor density. Above a L. minor biomass

  1. Classical limit for scalar fields at high temperature

    International Nuclear Information System (INIS)

    Buchmueller, W.; Jakovac, A.

    1998-01-01

    We study real-time correlation functions in scalar quantum field theories at temperature T=1/β. We show that the behaviour of soft, long-wavelength modes is determined by classical statistical field theory. The loss of quantum coherence is due to interactions with the soft modes of the thermal bath. The soft modes are separated from the hard modes by an infrared cutoff Λ<<1/(ℎβ). Integrating out the hard modes yields an effective theory for the soft modes. The infrared cutoff Λ controls corrections to the classical limit which are O(ℎβΛ). As an application, the plasmon damping rate is calculated. (orig.)

  2. Animal Welfare Groups Press for Limits on High School Research.

    Science.gov (United States)

    BioScience, 1979

    1979-01-01

    Discussions from the conference on "The Use of Animals in High School Biology Classes" are highlighted in this article. The list of science fair rules, which resulted from the conference, is included. (SA)

  3. Predicting Future High-Cost Schizophrenia Patients Using High-Dimensional Administrative Data

    Directory of Open Access Journals (Sweden)

    Yajuan Wang

    2017-06-01

    Full Text Available BackgroundThe burden of serious and persistent mental illness such as schizophrenia is substantial and requires health-care organizations to have adequate risk adjustment models to effectively allocate their resources to managing patients who are at the greatest risk. Currently available models underestimate health-care costs for those with mental or behavioral health conditions.ObjectivesThe study aimed to develop and evaluate predictive models for identification of future high-cost schizophrenia patients using advanced supervised machine learning methods.MethodsThis was a retrospective study using a payer administrative database. The study cohort consisted of 97,862 patients diagnosed with schizophrenia (ICD9 code 295.* from January 2009 to June 2014. Training (n = 34,510 and study evaluation (n = 30,077 cohorts were derived based on 12-month observation and prediction windows (PWs. The target was average total cost/patient/month in the PW. Three models (baseline, intermediate, final were developed to assess the value of different variable categories for cost prediction (demographics, coverage, cost, health-care utilization, antipsychotic medication usage, and clinical conditions. Scalable orthogonal regression, significant attribute selection in high dimensions method, and random forests regression were used to develop the models. The trained models were assessed in the evaluation cohort using the regression R2, patient classification accuracy (PCA, and cost accuracy (CA. The model performance was compared to the Centers for Medicare & Medicaid Services Hierarchical Condition Categories (CMS-HCC model.ResultsAt top 10% cost cutoff, the final model achieved 0.23 R2, 43% PCA, and 63% CA; in contrast, the CMS-HCC model achieved 0.09 R2, 27% PCA with 45% CA. The final model and the CMS-HCC model identified 33 and 22%, respectively, of total cost at the top 10% cost cutoff.ConclusionUsing advanced feature selection leveraging detailed

  4. 42 CFR 412.84 - Payment for extraordinarily high-cost cases (cost outliers).

    Science.gov (United States)

    2010-10-01

    ... obtains accurate data with which to calculate either an operating or capital cost-to-charge ratio (or both... outlier payments will be based on operating and capital cost-to-charge ratios calculated based on a ratio... outliers). 412.84 Section 412.84 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF...

  5. Fibre and components induced limitations in high capacity optical networks

    DEFF Research Database (Denmark)

    Peucheret, Christophe

    2003-01-01

    The design of future all-optical networks relies on the knowledge of the physical layer transport properties. In this thesis, we focus on two types of system impairments: those induced by the non-ideal transfer functions of optical filters to be found in network elements such as optical add...... design in order to maximise the spectral efficiency in a four add-drop node ring network. The concept of "normalised transmission sections" is introduced in order to ease the dimensioning of transparent domains in future all-optical networks. Normalised sections based on standard single mode fibre (SMF......-drop multiplexers (OADM) and optical cross-connects (OXC), as well as those due to the interaction of group-velocity dispersion, optical fibre non-linearities and accumulation of amplifier noise in the transmission path. The dispersion of fibre optics components is shown to limit their cascadability. Dispersion...

  6. Feasibility of Using Low-Cost Motion Capture for Automated Screening of Shoulder Motion Limitation after Breast Cancer Surgery.

    Directory of Open Access Journals (Sweden)

    Valeriya Gritsenko

    Full Text Available To determine if a low-cost, automated motion analysis system using Microsoft Kinect could accurately measure shoulder motion and detect motion impairments in women following breast cancer surgery.Descriptive study of motion measured via 2 methods.Academic cancer center oncology clinic.20 women (mean age = 60 yrs were assessed for active and passive shoulder motions during a routine post-operative clinic visit (mean = 18 days after surgery following mastectomy (n = 4 or lumpectomy (n = 16 for breast cancer.Participants performed 3 repetitions of active and passive shoulder motions on the side of the breast surgery. Arm motion was recorded using motion capture by Kinect for Windows sensor and on video. Goniometric values were determined from video recordings, while motion capture data were transformed to joint angles using 2 methods (body angle and projection angle.Correlation of motion capture with goniometry and detection of motion limitation.Active shoulder motion measured with low-cost motion capture agreed well with goniometry (r = 0.70-0.80, while passive shoulder motion measurements did not correlate well. Using motion capture, it was possible to reliably identify participants whose range of shoulder motion was reduced by 40% or more.Low-cost, automated motion analysis may be acceptable to screen for moderate to severe motion impairments in active shoulder motion. Automatic detection of motion limitation may allow quick screening to be performed in an oncologist's office and trigger timely referrals for rehabilitation.

  7. Feasibility of Using Low-Cost Motion Capture for Automated Screening of Shoulder Motion Limitation after Breast Cancer Surgery.

    Science.gov (United States)

    Gritsenko, Valeriya; Dailey, Eric; Kyle, Nicholas; Taylor, Matt; Whittacre, Sean; Swisher, Anne K

    2015-01-01

    To determine if a low-cost, automated motion analysis system using Microsoft Kinect could accurately measure shoulder motion and detect motion impairments in women following breast cancer surgery. Descriptive study of motion measured via 2 methods. Academic cancer center oncology clinic. 20 women (mean age = 60 yrs) were assessed for active and passive shoulder motions during a routine post-operative clinic visit (mean = 18 days after surgery) following mastectomy (n = 4) or lumpectomy (n = 16) for breast cancer. Participants performed 3 repetitions of active and passive shoulder motions on the side of the breast surgery. Arm motion was recorded using motion capture by Kinect for Windows sensor and on video. Goniometric values were determined from video recordings, while motion capture data were transformed to joint angles using 2 methods (body angle and projection angle). Correlation of motion capture with goniometry and detection of motion limitation. Active shoulder motion measured with low-cost motion capture agreed well with goniometry (r = 0.70-0.80), while passive shoulder motion measurements did not correlate well. Using motion capture, it was possible to reliably identify participants whose range of shoulder motion was reduced by 40% or more. Low-cost, automated motion analysis may be acceptable to screen for moderate to severe motion impairments in active shoulder motion. Automatic detection of motion limitation may allow quick screening to be performed in an oncologist's office and trigger timely referrals for rehabilitation.

  8. Performance Limitations in High-Energy Ion Colliders

    CERN Document Server

    Fischer, Wolfram

    2005-01-01

    High-energy ion colliders (hadron colliders operating with species other than protons) are premier research tools for nuclear physics. The collision energy and high luminosity are important design and operations considerations. However, the experiments also expect flexibility with frequent changes in the collision energy, lattice configuration, and ion species, including asymmetric collisions. For the creation, acceleration, and storage of bright intense ion beams, attention must be paid to space charge, charge exchange, and intra-beam scattering effects. The latter leads to luminosity lifetimes of only a few hours for heavy ions. Ultimately cooling at full energy is needed to overcome this effect. Currently, the Relativistic Heavy Ion Collider at BNL is the only operating high-energy ion collider. The Large Hadron Collider, under construction at CERN, will also run with heavy ions.

  9. Dynamic flood webmapping: an operational and cost-limited tool to optimize crisis management

    Directory of Open Access Journals (Sweden)

    Strappazzon Quentin

    2016-01-01

    Full Text Available Due to strong climate variations and the multiplication of flood events, protection based strategies are no longer sufficient to handle a watershed scale crisis. Monitoring, prediction and alert procedures are required to ensure effective crisis and post-crisis management which explains the recent interest for real time predictions systems. Nevertheless, this kind of system, when fully implemented with in-situ monitoring network, meteorological forecast inputs, hydrological and hydraulic modelling and flood mapping, are often postponed or cancelled because of both their cost and time scale. That is why Prolog Ingénierie and the SyAGE have developed, as an economical and technical sustainable alternative, a tool providing shared access to a real time mapping of current and predicted flooded areas along with a dynamic listing of exposed stakes (such as public buildings, sensible infrastructures, environmental buildings, roads. The update of these maps is performed from the combination of predicted water levels in the river and a flood envelop library (based on 1D/2D hydraulic model results for a wide panel of discharges and hydraulic structures states conditions. This tool has already been implemented on the downstream part of the Yerres River, a tributary of the Seine River in France.

  10. High Efficiency and Low Cost Thermal Energy Storage System

    Energy Technology Data Exchange (ETDEWEB)

    Sienicki, James J. [Argonne National Lab. (ANL), Argonne, IL (United States). Nuclear Engineering Division; Lv, Qiuping [Argonne National Lab. (ANL), Argonne, IL (United States). Nuclear Engineering Division; Moisseytsev, Anton [Argonne National Lab. (ANL), Argonne, IL (United States). Nuclear Engineering Division; Bucknor, Matthew [Argonne National Lab. (ANL), Argonne, IL (United States). Nuclear Engineering Division

    2017-09-29

    BgtL, LLC (BgtL) is focused on developing and commercializing its proprietary compact technology for processes in the energy sector. One such application is a compact high efficiency Thermal Energy Storage (TES) system that utilizes the heat of fusion through phase change between solid and liquid to store and release energy at high temperatures and incorporate state-of-the-art insulation to minimize heat dissipation. BgtL’s TES system would greatly improve the economics of existing nuclear and coal-fired power plants by allowing the power plant to store energy when power prices are low and sell power into the grid when prices are high. Compared to existing battery storage technology, BgtL’s novel thermal energy storage solution can be significantly less costly to acquire and maintain, does not have any waste or environmental emissions, and does not deteriorate over time; it can keep constant efficiency and operates cleanly and safely. BgtL’s engineers are experienced in this field and are able to design and engineer such a system to a specific power plant’s requirements. BgtL also has a strong manufacturing partner to fabricate the system such that it qualifies for an ASME code stamp. BgtL’s vision is to be the leading provider of compact systems for various applications including energy storage. BgtL requests that all technical information about the TES designs be protected as proprietary information. To honor that request, only non-proprietay summaries are included in this report.

  11. High Thermal Conductivity and High Wear Resistance Tool Steels for cost-effective Hot Stamping Tools

    Science.gov (United States)

    Valls, I.; Hamasaiid, A.; Padré, A.

    2017-09-01

    In hot stamping/press hardening, in addition to its shaping function, the tool controls the cycle time, the quality of the stamped components through determining the cooling rate of the stamped blank, the production costs and the feasibility frontier for stamping a given component. During the stamping, heat is extracted from the stamped blank and transported through the tool to the cooling medium in the cooling lines. Hence, the tools’ thermal properties determine the cooling rate of the blank, the heat transport mechanism, stamping times and temperature distribution. The tool’s surface resistance to adhesive and abrasive wear is also an important cost factor, as it determines the tool durability and maintenance costs. Wear is influenced by many tool material parameters, such as the microstructure, composition, hardness level and distribution of strengthening phases, as well as the tool’s working temperature. A decade ago, Rovalma developed a hot work tool steel for hot stamping that features a thermal conductivity of more than double that of any conventional hot work tool steel. Since that time, many complimentary grades have been developed in order to provide tailored material solutions as a function of the production volume, degree of blank cooling and wear resistance requirements, tool geometries, tool manufacturing method, type and thickness of the blank material, etc. Recently, Rovalma has developed a new generation of high thermal conductivity, high wear resistance tool steel grades that enable the manufacture of cost effective tools for hot stamping to increase process productivity and reduce tool manufacturing costs and lead times. Both of these novel grades feature high wear resistance and high thermal conductivity to enhance tool durability and cut cycle times in the production process of hot stamped components. Furthermore, one of these new grades reduces tool manufacturing costs through low tool material cost and hardening through readily

  12. Does High Educational Attainment Limit the Availability of Romantic Partners?

    Science.gov (United States)

    Burt, Isaac; Lewis, Sally V.; Beverly, Monifa G.; Patel, Samir H.

    2010-01-01

    Research indicates that highly educated individuals endure hardships in finding suitable romantic partners. Romantic hardships affect social and emotional adjustment levels, leading to low self-efficacy in relationship decision making. To address the need for research pertaining to this topic, the authors explored the experiences of eight…

  13. Production of solidified high level wastes: a cost comparison of solidification processes

    International Nuclear Information System (INIS)

    1977-06-01

    Differential cost estimates of the annual operating and maintenance costs and the capital costs for five HLW Waste Solidification Alternates were developed. The annual operating and maintenance cost estimates included the cost of labor, consumables, utilities, shipping casks, shipping and disposal at a federal repository. The capital cost included the cost of the component, installation and building. The differential cost estimates do not include equipment and facilities which are either shared with the reprocessing facility or are common between all of the alternates. Total annual cost differential between the five waste form alternates is summarized in tabular form. The Borosilicate Glass Alternate has the lowest total annual cost. The other alternates have higher costs which range from $6.6 M to $7.4 M per year higher than the Glass alternate with the Supercalcine being the highest cost at $7.4 M per year differential. The major items in the cost estimates are then disposal costs in the operating cost estimates and the HLW Storage Tanks in the capital cost estimates. The Supercalcine Multibarrier Alternate ships 180 canisters per year more than the other alternates and consequently has a significantly higher operating cost. However, off-setting this the Supercalcine Multibarrier Alternate does not require HLW Storage Tanks for decay because of the high heat conductivity of this product and correspondingly the capital cost for this alternate is significantly lower than the other alternates. The radiological risk values are correlated with the cost evaluation normalized to cost ($)/MWe-yr

  14. High-temperature superconducting fault-current limiter - optimisation of superconducting elements

    International Nuclear Information System (INIS)

    2004-01-01

    This report summarises the findings of a study initiated to continue the work of a DTI-LINK Collaborative Research Programme 'Enhancing the Properties of Bulk High Temperature Superconductors and their Potential Application as Fault Current Limiters (FCL). Details are given of computer modelling of the quenching process involving the transition from superconducting to normal conducting states undergone by the material when large currents are present. The design of compound elements, and a multi-element model are described along with FCL design covering distribution bus-coupler, embedded generator connection, larger generator connection, hazardous area safety, and interconnection to fault-prone network. The evaluation of thermal loss, test equipment and schedule, the optimised element, installed cost data, and the UK market are considered

  15. Reduced oxygen at high altitude limits maximum size.

    Science.gov (United States)

    Peck, L S; Chapelle, G

    2003-11-07

    The trend towards large size in marine animals with latitude, and the existence of giant marine species in polar regions have long been recognized, but remained enigmatic until a recent study showed it to be an effect of increased oxygen availability in sea water of a low temperature. The effect was apparent in data from 12 sites worldwide because of variations in water oxygen content controlled by differences in temperature and salinity. Another major physical factor affecting oxygen content in aquatic environments is reduced pressure at high altitude. Suitable data from high-altitude sites are very scarce. However, an exceptionally rich crustacean collection, which remains largely undescribed, was obtained by the British 1937 expedition from Lake Titicaca on the border between Peru and Bolivia in the Andes at an altitude of 3809 m. We show that in Lake Titicaca the maximum length of amphipods is 2-4 times smaller than other low-salinity sites (Caspian Sea and Lake Baikal).

  16. Manufacturing High-Quality Carbon Nanotubes at Lower Cost

    Science.gov (United States)

    Benavides, Jeanette M.; Lidecker, Henning

    2004-01-01

    A modified electric-arc welding process has been developed for manufacturing high-quality batches of carbon nanotubes at relatively low cost. Unlike in some other processes for making carbon nanotubes, metal catalysts are not used and, consequently, it is not necessary to perform extensive cleaning and purification. Also, unlike some other processes, this process is carried out at atmospheric pressure under a hood instead of in a closed, pressurized chamber; as a result, the present process can be implemented more easily. Although the present welding-based process includes an electric arc, it differs from a prior electric-arc nanotube-production process. The welding equipment used in this process includes an AC/DC welding power source with an integral helium-gas delivery system and circulating water for cooling an assembly that holds one of the welding electrodes (in this case, the anode). The cathode is a hollow carbon (optionally, graphite) rod having an outside diameter of 2 in. (approximately equal to 5.1 cm) and an inside diameter of 5/8 in. (approximately equal to 1.6 cm). The cathode is partly immersed in a water bath, such that it protrudes about 2 in. (about 5.1 cm) above the surface of the water. The bottom end of the cathode is held underwater by a clamp, to which is connected the grounding cable of the welding power source. The anode is a carbon rod 1/8 in. (approximately equal to 0.3 cm) in diameter. The assembly that holds the anode includes a thumbknob- driven mechanism for controlling the height of the anode. A small hood is placed over the anode to direct a flow of helium downward from the anode to the cathode during the welding process. A bell-shaped exhaust hood collects the helium and other gases from the process. During the process, as the anode is consumed, the height of the anode is adjusted to maintain an anode-to-cathode gap of 1 mm. The arc-welding process is continued until the upper end of the anode has been lowered to a specified height

  17. Association of prescription abandonment with cost share for high-cost specialty pharmacy medications.

    Science.gov (United States)

    Gleason, Patrick P; Starner, Catherine I; Gunderson, Brent W; Schafer, Jeremy A; Sarran, H Scott

    2009-10-01

    In 2008, specialty medications accounted for 15.1% of total pharmacy benefit medication spending, and per member expenditures have increased by 11.1% annually from 2004 to 2008 within a commercially insured population of 8 million members. Insurers face increasing pressure to control specialty medication expenditures and to rely on increasing member cost share through creation of a fourth copayment tier within the incentive-based formulary pharmacy benefit system. Data are needed on the influence that member out-of-pocket (OOP) expense may have on prescription abandonment (defined as the patient never actually taking possession of the medication despite evidence of a written prescription generated by a prescriber). To explore the relationship between prescription abandonment and OOP expense among individuals newly initiating high-cost medication therapy with a tumor necrosis factor (TNF) blocker or multiple sclerosis (MS) biologic agent. This observational cross-sectional study queried a midwestern and southern U.S. database of 13,172,480 commercially insured individuals to find members with a pharmacy benefit-adjudicated claim for a TNF blocker or MS specialty medication during the period from July 2006 through June 2008. Prescription abandonment was assessed among continuously enrolled members newly initiating TNF blocker or MS therapy. Prescription abandonment was defined as reversal of the adjudicated claim with no evidence of a subsequent additional adjudicated paid claim in the ensuing 90 days. Separate analyses for MS and TNF blocker therapy were performed to assess the association between member OOP expense and abandonment rate using the Cochran-Armitage test for trend and multivariate logistic regression. Members were placed into 1 of the 7 following OOP expense groups per claim: $0-$100, $101-$150, $151-$200, $201-$250, $251-$350, $351-$500, or more than $500. The association of MS or TNF blocker abandonment rate with OOP expense was tested with logistic

  18. Design of Low Cost, Highly Adsorbent Activated Carbon Fibers

    National Research Council Canada - National Science Library

    Mangun, Christian

    2003-01-01

    .... EKOS has developed a novel activated carbon fiber - (ACF) that combines the low cost and durability of GAC with tailored pore size and pore surface chemistry for improved defense against chemical agents...

  19. A Low-Cost, High-Precision Navigator, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Toyon Research Corporation proposes to develop and demonstrate a prototype low-cost precision navigation system using commercial-grade gyroscopes and accelerometers....

  20. A high-performance, low-cost, leading edge discriminator

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 65; Issue 2 ... commercial discriminators. A low-cost discriminator is an essential requirement of the GRAPES-3 experiment where a large number of discriminator channels are used.

  1. The high cost of clinical negligence litigation in the NHS.

    Science.gov (United States)

    Tingle, John

    2017-03-09

    John Tingle, Reader in Health Law at Nottingham Trent University, discusses a consultation document from the Department of Health on introducing fixed recoverable costs in lower-value clinical negligence claims.

  2. Intra- and trans-generational costs of reduced female body size caused by food limitation early in life in mites.

    Science.gov (United States)

    Walzer, Andreas; Schausberger, Peter

    2013-01-01

    Food limitation early in life may be compensated for by developmental plasticity resulting in accelerated development enhancing survival at the expense of small adult body size. However and especially for females in non-matching maternal and offspring environments, being smaller than the standard may incur considerable intra- and trans-generational costs. Here, we evaluated the costs of small female body size induced by food limitation early in life in the sexually size-dimorphic predatory mite Phytoseiulus persimilis. Females are larger than males. These predators are adapted to exploit ephemeral spider mite prey patches. The intra- and trans-generational effects of small maternal body size manifested in lower maternal survival probabilities, decreased attractiveness for males, and a reduced number and size of eggs compared to standard-sized females. The trans-generational effects of small maternal body size were sex-specific with small mothers producing small daughters but standard-sized sons. Small female body size apparently intensified the well-known costs of sexual activity because mortality of small but not standard-sized females mainly occurred shortly after mating. The disadvantages of small females in mating and egg production may be generally explained by size-associated morphological and physiological constraints. Additionally, size-assortative mate preferences of standard-sized mates may have rendered small females disproportionally unattractive mating partners. We argue that the sex-specific trans-generational effects were due to sexual size dimorphism - females are the larger sex and thus more strongly affected by maternal stress than the smaller males - and to sexually selected lower plasticity of male body size.

  3. Intra- and Trans-Generational Costs of Reduced Female Body Size Caused by Food Limitation Early in Life in Mites

    Science.gov (United States)

    Walzer, Andreas; Schausberger, Peter

    2013-01-01

    Background Food limitation early in life may be compensated for by developmental plasticity resulting in accelerated development enhancing survival at the expense of small adult body size. However and especially for females in non-matching maternal and offspring environments, being smaller than the standard may incur considerable intra- and trans-generational costs. Methodology/Principal Findings Here, we evaluated the costs of small female body size induced by food limitation early in life in the sexually size-dimorphic predatory mite Phytoseiulus persimilis. Females are larger than males. These predators are adapted to exploit ephemeral spider mite prey patches. The intra- and trans-generational effects of small maternal body size manifested in lower maternal survival probabilities, decreased attractiveness for males, and a reduced number and size of eggs compared to standard-sized females. The trans-generational effects of small maternal body size were sex-specific with small mothers producing small daughters but standard-sized sons. Conclusions/Significance Small female body size apparently intensified the well-known costs of sexual activity because mortality of small but not standard-sized females mainly occurred shortly after mating. The disadvantages of small females in mating and egg production may be generally explained by size-associated morphological and physiological constraints. Additionally, size-assortative mate preferences of standard-sized mates may have rendered small females disproportionally unattractive mating partners. We argue that the sex-specific trans-generational effects were due to sexual size dimorphism – females are the larger sex and thus more strongly affected by maternal stress than the smaller males – and to sexually selected lower plasticity of male body size. PMID:24265745

  4. Intra- and trans-generational costs of reduced female body size caused by food limitation early in life in mites.

    Directory of Open Access Journals (Sweden)

    Andreas Walzer

    Full Text Available Food limitation early in life may be compensated for by developmental plasticity resulting in accelerated development enhancing survival at the expense of small adult body size. However and especially for females in non-matching maternal and offspring environments, being smaller than the standard may incur considerable intra- and trans-generational costs.Here, we evaluated the costs of small female body size induced by food limitation early in life in the sexually size-dimorphic predatory mite Phytoseiulus persimilis. Females are larger than males. These predators are adapted to exploit ephemeral spider mite prey patches. The intra- and trans-generational effects of small maternal body size manifested in lower maternal survival probabilities, decreased attractiveness for males, and a reduced number and size of eggs compared to standard-sized females. The trans-generational effects of small maternal body size were sex-specific with small mothers producing small daughters but standard-sized sons.Small female body size apparently intensified the well-known costs of sexual activity because mortality of small but not standard-sized females mainly occurred shortly after mating. The disadvantages of small females in mating and egg production may be generally explained by size-associated morphological and physiological constraints. Additionally, size-assortative mate preferences of standard-sized mates may have rendered small females disproportionally unattractive mating partners. We argue that the sex-specific trans-generational effects were due to sexual size dimorphism - females are the larger sex and thus more strongly affected by maternal stress than the smaller males - and to sexually selected lower plasticity of male body size.

  5. Assessing the high costs of new nuclear power plants

    International Nuclear Information System (INIS)

    Komanoff, C.

    1984-01-01

    The variation in nuclear plant capital costs, both over time and within the current generation of plants, is considerable and is one of the impressive facts associated with that technology. This article concerns statistical methods for determining relative management efficiency or inefficiency in nuclear plant construction. It emphasizes the need to adjust raw cost data for important variables in order to make fair comparisons among disparate projects. The analysis identifies the costliest and least-costly projects and elucidates trends that helped or harmed several or more projects at the same time. Its findings can form a supplement and guide for engineering and management audits of individual nuclear projects. 5 references, 1 figure, 1 table

  6. Alternative ceramic circuit constructions for low cost, high reliability applications

    International Nuclear Information System (INIS)

    Modes, Ch.; O'Neil, M.

    1997-01-01

    The growth in the use of hybrid circuit technology has recently been challenged by recent advances in low cost laminate technology, as well as the continued integration of functions into IC's. Size reduction of hybrid 'packages' has turned out to be a means to extend the useful life of this technology. The suppliers of thick film materials technology have responded to this challenge by developing a number of technology options to reduce circuit size, increase density, and reduce overall cost, while maintaining or increasing reliability. This paper provides an overview of the processes that have been developed, and, in many cases are used widely to produce low cost, reliable microcircuits. Comparisons of each of these circuit fabrication processes are made with a discussion of advantages and disadvantages of each technology. (author)

  7. Cost tradeoffs in consequence management at nuclear power plants: A risk based approach to setting optimal long-term interdiction limits for regulatory analyses

    International Nuclear Information System (INIS)

    Mubayi, V.

    1995-05-01

    The consequences of severe accidents at nuclear power plants can be limited by various protective actions, including emergency responses and long-term measures, to reduce exposures of affected populations. Each of these protective actions involve costs to society. The costs of the long-term protective actions depend on the criterion adopted for the allowable level of long-term exposure. This criterion, called the ''long term interdiction limit,'' is expressed in terms of the projected dose to an individual over a certain time period from the long-term exposure pathways. The two measures of offsite consequences, latent cancers and costs, are inversely related and the choice of an interdiction limit is, in effect, a trade-off between these two measures. By monetizing the health effects (through ascribing a monetary value to life lost), the costs of the two consequence measures vary with the interdiction limit, the health effect costs increasing as the limit is relaxed and the protective action costs decreasing. The minimum of the total cost curve can be used to calculate an optimal long term interdiction limit. The calculation of such an optimal limit is presented for each of five US nuclear power plants which were analyzed for severe accident risk in the NUREG-1150 program by the Nuclear Regulatory Commission

  8. The High Direct Medical Costs of Prader-Willi Syndrome.

    Science.gov (United States)

    Shoffstall, Andrew J; Gaebler, Julia A; Kreher, Nerissa C; Niecko, Timothy; Douglas, Diah; Strong, Theresa V; Miller, Jennifer L; Stafford, Diane E; Butler, Merlin G

    2016-08-01

    To assess medical resource utilization associated with Prader-Willi syndrome (PWS) in the US, hypothesized to be greater relative to a matched control group without PWS. We used a retrospective case-matched control design and longitudinal US administrative claims data (MarketScan) during a 5-year enrollment period (2009-2014). Patients with PWS were identified by Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code 759.81. Controls were matched on age, sex, and payer type. Outcomes included total, outpatient, inpatient and prescription costs. After matching and application of inclusion/exclusion criteria, we identified 2030 patients with PWS (1161 commercial, 38 Medicare supplemental, and 831 Medicaid). Commercially insured patients with PWS (median age 10 years) had 8.8-times greater total annual direct medical costs than their counterparts without PWS (median age 10 years: median costs $14 907 vs $819; P < .0001; mean costs: $28 712 vs $3246). Outpatient care comprised the largest portion of medical resource utilization for enrollees with and without PWS (median $5605 vs $675; P < .0001; mean $11 032 vs $1804), followed by mean annual inpatient and medication costs, which were $10 879 vs $1015 (P < .001) and $6801 vs $428 (P < .001), respectively. Total annual direct medical costs were ∼42% greater for Medicaid-insured patients with PWS than their commercially insured counterparts, an increase partly explained by claims for Medicaid Waiver day and residential habilitation. Direct medical resource utilization was considerably greater among patients with PWS than members without the condition. This study provides a first step toward quantifying the financial burden of PWS posed to individuals, families, and society. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  9. Thin film solar modules: the low cost, high throughput and versatile alternative to Si wafers

    Energy Technology Data Exchange (ETDEWEB)

    Hegedus, S. [Delaware Univ., Inst. of Energy Conversion, Newark, DE (United States)

    2006-07-01

    Thin film solar cells (TFSC) have passed adolescence and are ready to make a substantial contribution to the world's electricity generation. They can have advantages over c-Si solar modules in ease of large area, lower cost manufacturing and in several types of applications. Factors which limit TFSC module performance relative to champion cell performance are discussed along with the importance of increased throughput and yield. The consensus of several studies is that all TFSC can achieve costs below 1 $/W if manufactured at sufficiently large scale >100 MW using parallel lines of cloned equipment with high material utilization and spray-on encapsulants. There is significant new commercial interest in TFSC from small investors and large corporations, validating the thin film approach. Unique characteristics are discussed which give TFSC an advantage over c-Si in two specific markets: small rural solar home systems and building integrated photovoltaic installations. TFSC have outperformed c-Si in annual energy production (kWhrs/kW), have demonstrated outdoor durability comparable to c-Si and are being used in MW scale installations worldwide. The merits of the thin film approach cannot be judged on the basis of efficiency alone but must also account for module performance and potential for low cost. TFSC advocates should promote their unique virtues compared to c-Si: lower cost, higher kWhr/kW output, higher battery charging current, attractive visual appearance, flexible substrates, long-term stability comparable to c-Si, and multiple pathways for deposition with room for innovation and evolutionary improvement. There is a huge market for TFSC even at today's efficiency if costs can be reduced. A brief window of opportunity exists for TFSC over the next few years due the Si shortage. The demonstrated capabilities and advantages of TFSC must be proclaimed more persistently to funding decision-makers and customers without minimizing the remaining

  10. Bipolar-power-transistor-based limiter for high frequency ultrasound imaging systems.

    Science.gov (United States)

    Choi, Hojong; Yang, Hao-Chung; Shung, K Kirk

    2014-03-01

    High performance limiters are described in this paper for applications in high frequency ultrasound imaging systems. Limiters protect the ultrasound receiver from the high voltage (HV) spikes produced by the transmitter. We present a new bipolar power transistor (BPT) configuration and compare its design and performance to a diode limiter used in traditional ultrasound research and one commercially available limiter. Limiter performance depends greatly on the insertion loss (IL), total harmonic distortion (THD) and response time (RT), each of which will be evaluated in all the limiters. The results indicated that, compared with commercial limiter, BPT-based limiter had less IL (-7.7 dB), THD (-74.6 dB) and lower RT (43 ns) at 100 MHz. To evaluate the capability of these limiters, they were connected to a 100 MHz single element transducer and a two-way pulse-echo test was performed. It was found that the -6 dB bandwidth and sensitivity of the transducer using BPT-based limiter were better than those of the commercial limiter by 22% and 140%, respectively. Compared to the commercial limiter, BPT-based limiter is shown to be capable of minimizing signal attenuation, RT and THD at high frequencies and is thus suited for high frequency ultrasound applications. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Many Mobile Health Apps Target High-Need, High-Cost Populations, But Gaps Remain.

    Science.gov (United States)

    Singh, Karandeep; Drouin, Kaitlin; Newmark, Lisa P; Lee, JaeHo; Faxvaag, Arild; Rozenblum, Ronen; Pabo, Erika A; Landman, Adam; Klinger, Elissa; Bates, David W

    2016-12-01

    With rising smartphone ownership, mobile health applications (mHealth apps) have the potential to support high-need, high-cost populations in managing their health. While the number of available mHealth apps has grown substantially, no clear strategy has emerged on how providers should evaluate and recommend such apps to patients. Key stakeholders, including medical professional societies, insurers, and policy makers, have largely avoided formally recommending apps, which forces patients to obtain recommendations from other sources. To help stakeholders overcome barriers to reviewing and recommending apps, we evaluated 137 patient-facing mHealth apps-those intended for use by patients to manage their health-that were highly rated by consumers and recommended by experts and that targeted high-need, high-cost populations. We found that there is a wide variety of apps in the marketplace but that few apps address the needs of the patients who could benefit the most. We also found that consumers' ratings were poor indications of apps' clinical utility or usability and that most apps did not respond appropriately when a user entered potentially dangerous health information. Going forward, data privacy and security will continue to be major concerns in the dissemination of mHealth apps. Project HOPE—The People-to-People Health Foundation, Inc.

  12. The High Cost of Harsh Discipline and Its Disparate Impact

    Science.gov (United States)

    Rumberger, Russell W.; Losen, Daniel J.

    2016-01-01

    School suspension rates have been rising since the early 1970s, especially for children of color. One body of research has demonstrated that suspension from school is harmful to students, as it increases the risk of retention and school dropout. Another has demonstrated that school dropouts impose huge social costs on their states and localities,…

  13. Distribution Grid Integration Costs Under High PV Penetrations Workshop |

    Science.gov (United States)

    utility business model and structure: policies and regulations, revenue requirements and investment Practices Panel 3: Future Directions in Grid Integration Cost-Benefit Analysis Determining Distribution Grid into Utility Planning Notes on Future Needs All speakers were asked to include their opinions on

  14. Fundamental phenomena affecting low temperature combustion and HCCI engines, high load limits and strategies for extending these limits

    KAUST Repository

    Saxena, Samveg; Bedoya, Ivá n D.

    2013-01-01

    Low temperature combustion (LTC) engines are an emerging engine technology that offers an alternative to spark-ignited and diesel engines. One type of LTC engine, the homogeneous charge compression ignition (HCCI) engine, uses a well-mixed fuel–air charge like spark-ignited engines and relies on compression ignition like diesel engines. Similar to diesel engines, the use of high compression ratios and removal of the throttling valve in HCCI allow for high efficiency operation, thereby allowing lower CO2 emissions per unit of work delivered by the engine. The use of a highly diluted well-mixed fuel–air charge allows for low emissions of nitrogen oxides, soot and particulate matters, and the use of oxidation catalysts can allow low emissions of unburned hydrocarbons and carbon monoxide. As a result, HCCI offers the ability to achieve high efficiencies comparable with diesel while also allowing clean emissions while using relatively inexpensive aftertreatment technologies. HCCI is not, however, without its challenges. Traditionally, two important problems prohibiting market penetration of HCCI are 1) inability to achieve high load, and 2) difficulty in controlling combustion timing. Recent research has significantly mitigated these challenges, and thus HCCI has a promising future for automotive and power generation applications. This article begins by providing a comprehensive review of the physical phenomena governing HCCI operation, with particular emphasis on high load conditions. Emissions characteristics are then discussed, with suggestions on how to inexpensively enable low emissions of all regulated emissions. The operating limits that govern the high load conditions are discussed in detail, and finally a review of recent research which expands the high load limits of HCCI is discussed. Although this article focuses on the fundamental phenomena governing HCCI operation, it is also useful for understanding the fundamental phenomena in reactivity controlled

  15. Fundamental phenomena affecting low temperature combustion and HCCI engines, high load limits and strategies for extending these limits

    KAUST Repository

    Saxena, Samveg

    2013-10-01

    Low temperature combustion (LTC) engines are an emerging engine technology that offers an alternative to spark-ignited and diesel engines. One type of LTC engine, the homogeneous charge compression ignition (HCCI) engine, uses a well-mixed fuel–air charge like spark-ignited engines and relies on compression ignition like diesel engines. Similar to diesel engines, the use of high compression ratios and removal of the throttling valve in HCCI allow for high efficiency operation, thereby allowing lower CO2 emissions per unit of work delivered by the engine. The use of a highly diluted well-mixed fuel–air charge allows for low emissions of nitrogen oxides, soot and particulate matters, and the use of oxidation catalysts can allow low emissions of unburned hydrocarbons and carbon monoxide. As a result, HCCI offers the ability to achieve high efficiencies comparable with diesel while also allowing clean emissions while using relatively inexpensive aftertreatment technologies. HCCI is not, however, without its challenges. Traditionally, two important problems prohibiting market penetration of HCCI are 1) inability to achieve high load, and 2) difficulty in controlling combustion timing. Recent research has significantly mitigated these challenges, and thus HCCI has a promising future for automotive and power generation applications. This article begins by providing a comprehensive review of the physical phenomena governing HCCI operation, with particular emphasis on high load conditions. Emissions characteristics are then discussed, with suggestions on how to inexpensively enable low emissions of all regulated emissions. The operating limits that govern the high load conditions are discussed in detail, and finally a review of recent research which expands the high load limits of HCCI is discussed. Although this article focuses on the fundamental phenomena governing HCCI operation, it is also useful for understanding the fundamental phenomena in reactivity controlled

  16. Design of a Novel Low Cost Point of Care Tampon (POCkeT) Colposcope for Use in Resource Limited Settings

    Science.gov (United States)

    Lam, Christopher T.; Krieger, Marlee S.; Gallagher, Jennifer E.; Asma, Betsy; Muasher, Lisa C.; Schmitt, John W.; Ramanujam, Nimmi

    2015-01-01

    Introduction Current guidelines by WHO for cervical cancer screening in low- and middle-income countries involves visual inspection with acetic acid (VIA) of the cervix, followed by treatment during the same visit or a subsequent visit with cryotherapy if a suspicious lesion is found. Implementation of these guidelines is hampered by a lack of: trained health workers, reliable technology, and access to screening facilities. A low cost ultra-portable Point of Care Tampon based digital colposcope (POCkeT Colposcope) for use at the community level setting, which has the unique form factor of a tampon, can be inserted into the vagina to capture images of the cervix, which are on par with that of a state of the art colposcope, at a fraction of the cost. A repository of images to be compiled that can be used to empower front line workers to become more effective through virtual dynamic training. By task shifting to the community setting, this technology could potentially provide significantly greater cervical screening access to where the most vulnerable women live. The POCkeT Colposcope’s concentric LED ring provides comparable white and green field illumination at a fraction of the electrical power required in commercial colposcopes. Evaluation with standard optical imaging targets to assess the POCkeT Colposcope against the state of the art digital colposcope and other VIAM technologies. Results Our POCkeT Colposcope has comparable resolving power, color reproduction accuracy, minimal lens distortion, and illumination when compared to commercially available colposcopes. In vitro and pilot in vivo imaging results are promising with our POCkeT Colposcope capturing comparable quality images to commercial systems. Conclusion The POCkeT Colposcope is capable of capturing images suitable for cervical lesion analysis. Our portable low cost system could potentially increase access to cervical cancer screening in limited resource settings through task shifting to community

  17. Consequences of Reducing the Cost of PV Modules on a PV Wind Diesel Hybrid System with Limited Sizing Components

    Directory of Open Access Journals (Sweden)

    Jones S. Silva

    2012-01-01

    Full Text Available The use of renewable resources for power supply in family homes has passed the stage of utopia to became a reality, with limits set by technical and economic parameters. This paper presents the results of a project originated from the initiative of a middle-class family to achieve energy independence at home. The starting point was the concept of home with “zero energy” in which the total energy available is equal to the energy consumed. The solution devised to meet the energy demand of the residence in question is a PV wind diesel hybrid system connected to the grid, with the possibility of energy storage in batteries and in the form of heating water and the environment of the house. As a restriction, the family requested that the system would represent little impact to the lifestyle and landscape. This paper aims to assess the consequences of reductions in the cost of the PV modules on the optimization space, as conceived by the software Homer. The results show that for this system, a 50% reduction in the cost of PV modules allows all viable solutions including PV modules.

  18. Low cost, low tech SNP genotyping tools for resource-limited areas: Plague in Madagascar as a model.

    Science.gov (United States)

    Mitchell, Cedar L; Andrianaivoarimanana, Voahangy; Colman, Rebecca E; Busch, Joseph; Hornstra-O'Neill, Heidie; Keim, Paul S; Wagner, David M; Rajerison, Minoarisoa; Birdsell, Dawn N

    2017-12-01

    Genetic analysis of pathogenic organisms is a useful tool for linking human cases together and/or to potential environmental sources. The resulting data can also provide information on evolutionary patterns within a targeted species and phenotypic traits. However, the instruments often used to generate genotyping data, such as single nucleotide polymorphisms (SNPs), can be expensive and sometimes require advanced technologies to implement. This places many genotyping tools out of reach for laboratories that do not specialize in genetic studies and/or lack the requisite financial and technological resources. To address this issue, we developed a low cost and low tech genotyping system, termed agarose-MAMA, which combines traditional PCR and agarose gel electrophoresis to target phylogenetically informative SNPs. To demonstrate the utility of this approach for generating genotype data in a resource-constrained area (Madagascar), we designed an agarose-MAMA system targeting previously characterized SNPs within Yersinia pestis, the causative agent of plague. We then used this system to genetically type pathogenic strains of Y. pestis in a Malagasy laboratory not specialized in genetic studies, the Institut Pasteur de Madagascar (IPM). We conducted rigorous assay performance validations to assess potential variation introduced by differing research facilities, reagents, and personnel and found no difference in SNP genotyping results. These agarose-MAMA PCR assays are currently employed as an investigative tool at IPM, providing Malagasy researchers a means to improve the value of their plague epidemiological investigations by linking outbreaks to potential sources through genetic characterization of isolates and to improve understanding of disease ecology that may contribute to a long-term control effort. The success of our study demonstrates that the SNP-based genotyping capacity of laboratories in developing countries can be expanded with manageable financial cost for

  19. Providing strong Security and high privacy in low-cost RFID networks

    DEFF Research Database (Denmark)

    David, Mathieu; Prasad, Neeli R.

    2009-01-01

    Since the dissemination of Radio Frequency IDentification (RFID) tags is getting larger and larger, the requirement for strong security and privacy is also increasing. Low-cost and ultra-low-cost tags are being implemented on everyday products, and their limited resources constraints the security...

  20. High fitness costs of climate change-induced camouflage mismatch.

    Science.gov (United States)

    Zimova, Marketa; Mills, L Scott; Nowak, J Joshua

    2016-03-01

    Anthropogenic climate change has created myriad stressors that threaten to cause local extinctions if wild populations fail to adapt to novel conditions. We studied individual and population-level fitness costs of a climate change-induced stressor: camouflage mismatch in seasonally colour molting species confronting decreasing snow cover duration. Based on field measurements of radiocollared snowshoe hares, we found strong selection on coat colour molt phenology, such that animals mismatched with the colour of their background experienced weekly survival decreases up to 7%. In the absence of adaptive response, we show that these mortality costs would result in strong population-level declines by the end of the century. However, natural selection acting on wide individual variation in molt phenology might enable evolutionary adaptation to camouflage mismatch. We conclude that evolutionary rescue will be critical for hares and other colour molting species to keep up with climate change. © 2016 The Authors. Ecology Letters published by CNRS and John Wiley & Sons Ltd.

  1. HTGR high temperature process heat design and cost status report

    International Nuclear Information System (INIS)

    1981-12-01

    This report describes the status of the studies conducted on the 850 0 C ROT indirect cycle and the 950 0 C ROT direct cycle through the end of Fiscal Year 1981. Volume I provides summaries of the design and optimization studies and the resulting capital and product costs, for the HTGR/thermochemical pipeline concept. Additionally, preliminary evaluations are presented for coupling of candidate process applications to the HTGR system

  2. Capital and operating cost estimates for high temperature superconducting magnetic energy storage

    International Nuclear Information System (INIS)

    Schoenung, S.M.; Meier, W.R.; Fagaly, R.L.; Heiberger, M.; Stephens, R.B.; Leuer, J.A.; Guzman, R.A.

    1992-01-01

    Capital and operating costs have been estimated for mid-scale (2 to 200 Mwh) superconducting magnetic energy storage (SMES) designed to use high temperature superconductors (HTS). Capital costs are dominated by the cost of superconducting materials. Operating costs, primarily for regeneration, are significantly reduced for HTS-SMES in comparison to low temperature, conventional systems. This cost component is small compared to other O and M and capital components, when levelized annual costs are projected. In this paper, the developments required for HTS-SMES feasibility are discussed

  3. Museum genomics: low-cost and high-accuracy genetic data from historical specimens.

    Science.gov (United States)

    Rowe, Kevin C; Singhal, Sonal; Macmanes, Matthew D; Ayroles, Julien F; Morelli, Toni Lyn; Rubidge, Emily M; Bi, Ke; Moritz, Craig C

    2011-11-01

    Natural history collections are unparalleled repositories of geographical and temporal variation in faunal conditions. Molecular studies offer an opportunity to uncover much of this variation; however, genetic studies of historical museum specimens typically rely on extracting highly degraded and chemically modified DNA samples from skins, skulls or other dried samples. Despite this limitation, obtaining short fragments of DNA sequences using traditional PCR amplification of DNA has been the primary method for genetic study of historical specimens. Few laboratories have succeeded in obtaining genome-scale sequences from historical specimens and then only with considerable effort and cost. Here, we describe a low-cost approach using high-throughput next-generation sequencing to obtain reliable genome-scale sequence data from a traditionally preserved mammal skin and skull using a simple extraction protocol. We show that single-nucleotide polymorphisms (SNPs) from the genome sequences obtained independently from the skin and from the skull are highly repeatable compared to a reference genome. © 2011 Blackwell Publishing Ltd.

  4. Low-Cost High-Speed In-Plane Stroboscopic Micro-Motion Analyzer

    Directory of Open Access Journals (Sweden)

    Shashank S. Pandey

    2017-11-01

    Full Text Available Instrumentation for high-speed imaging and laser vibrometry is essential for the understanding and analysis of microstructure dynamics, but commercial instruments are largely unaffordable for most microelectromechanical systems (MEMS laboratories. We present the implementation of a very low cost in-plane micro motion stroboscopic analyzer that can be directly attached to a conventional probe station. The low-cost analyzer has been used to characterize the harmonic motion of 52.1 kHz resonating comb drive microactuators using ~50 ns pulsed light-emitting diode (LED stroboscope exposure times, producing sharp and high resolution (~0.5 μm device images at resonance, which rivals those of several orders of magnitude more expensive systems. This paper details the development of the high-speed stroboscopic imaging system and presents experimental results of motion analysis of example microstructures and a discussion of its operating limits. The system is shown to produce stable stroboscopic LED illumination to freeze device images up to 11 MHz.

  5. Cost-Effectiveness Analysis in Practice: Interventions to Improve High School Completion

    Science.gov (United States)

    Hollands, Fiona; Bowden, A. Brooks; Belfield, Clive; Levin, Henry M.; Cheng, Henan; Shand, Robert; Pan, Yilin; Hanisch-Cerda, Barbara

    2014-01-01

    In this article, we perform cost-effectiveness analysis on interventions that improve the rate of high school completion. Using the What Works Clearinghouse to select effective interventions, we calculate cost-effectiveness ratios for five youth interventions. We document wide variation in cost-effectiveness ratios between programs and between…

  6. CONSTRUCTION OF A DIFFERENTIAL ISOTHERMAL CALORIMETER OF HIGH SENSITIVITY AND LOW COST.

    OpenAIRE

    Trinca, RB; Perles, CE; Volpe, PLO

    2009-01-01

    CONSTRUCTION OF A DIFFERENTIAL ISOTHERMAL CALORIMETER OF HIGH SENSITIVITY AND LOW COST The high cost of sensitivity commercial calorimeters may represent an obstacle for many calorimetric research groups. This work describes (fie construction and calibration of a batch differential heat conduction calorimeter with sample cells volumes of about 400 mu L. The calorimeter was built using two small high sensibility square Peltier thermoelectric sensors and the total cost was estimated to be about...

  7. Ultra High Brightness/Low Cost Fiber Coupled Packaging, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — High peak power, high efficiency, high reliability lightweight, low cost QCW laser diode pump modules with up to 1000W of QCW output become possible with nLight's...

  8. What Contributes Most to High Health Care Costs? Health Care Spending in High Resource Patients.

    Science.gov (United States)

    Pritchard, Daryl; Petrilla, Allison; Hallinan, Shawn; Taylor, Donald H; Schabert, Vernon F; Dubois, Robert W

    2016-02-01

    U.S. health care spending nearly doubled in the decade from 2000-2010. Although the pace of increase has moderated recently, the rate of growth of health care costs is expected to be higher than the growth in the economy for the near future. Previous studies have estimated that 5% of patients account for half of all health care costs, while the top 1% of spenders account for over 27% of costs. The distribution of health care expenditures by type of service and the prevalence of particular health conditions for these patients is not clear, and is likely to differ from the overall population. To examine health care spending patterns and what contributes to costs for the top 5% of managed health care users based on total expenditures. This retrospective observational study employed a large administrative claims database analysis of health care claims of managed care enrollees across the full age and care spectrum. Direct health care expenditures were compared during calendar year 2011 by place of service (outpatient, inpatient, and pharmacy), payer type (commercially insured, Medicare Advantage, and Medicaid managed care), and therapy area between the full population and high resource patients (HRP). The mean total expenditure per HRP during calendar year 2011 was $43,104 versus $3,955 per patient for the full population. Treatment of back disorders and osteoarthritis contributed the largest share of expenditures in both HRP and the full study population, while chronic renal failure, heart disease, and some oncology treatments accounted for disproportionately higher expenditures in HRP. The share of overall expenditures attributed to inpatient services was significantly higher for HRP (40.0%) compared with the full population (24.6%), while the share of expenditures attributed to pharmacy (HRP = 18.1%, full = 21.4%) and outpatient services (HRP = 41.9%, full = 54.1%) was reduced. This pattern was observed across payer type. While the use of physician

  9. Running behavior and its energy cost in mice selectively bred for high voluntary locomotor activity.

    Science.gov (United States)

    Rezende, Enrico L; Gomes, Fernando R; Chappell, Mark A; Garland, Theodore

    2009-01-01

    Locomotion is central to behavior and intrinsic to many fitness-critical activities (e.g., migration, foraging), and it competes with other life-history components for energy. However, detailed analyses of how changes in locomotor activity and running behavior affect energy budgets are scarce. We quantified these effects in four replicate lines of house mice that have been selectively bred for high voluntary wheel running (S lines) and in their four nonselected control lines (C lines). We monitored wheel speeds and oxygen consumption for 24-48 h to determine daily energy expenditure (DEE), resting metabolic rate (RMR), locomotor costs, and running behavior (bout characteristics). Daily running distances increased roughly 50%-90% in S lines in response to selection. After we controlled for body mass effects, selection resulted in a 23% increase in DEE in males and a 6% increase in females. Total activity costs (DEE - RMR) accounted for 50%-60% of DEE in both S and C lines and were 29% higher in S males and 5% higher in S females compared with their C counterparts. Energetic costs of increased daily running distances differed between sexes because S females evolved higher running distances by running faster with little change in time spent running, while S males also spent 40% more time running than C males. This increase in time spent running impinged on high energy costs because the majority of running costs stemmed from "postural costs" (the difference between RMR and the zero-speed intercept of the speed vs. metabolic rate relationship). No statistical differences in these traits were detected between S and C females, suggesting that large changes in locomotor behavior do not necessarily effect overall energy budgets. Running behavior also differed between sexes: within S lines, males ran with more but shorter bouts than females. Our results indicate that selection effects on energy budgets can differ dramatically between sexes and that energetic constraints in S

  10. A LOW COST AND HIGH QUALITY SOLID FUEL FROM BIOMASS AND COAL FINES

    Energy Technology Data Exchange (ETDEWEB)

    John T. Kelly; George Miller; Mehdi Namazian

    2001-07-01

    Use of biomass wastes as fuels in existing boilers would reduce greenhouse gas emissions, SO2 and NOx emissions, while beneficially utilizing wastes. However, the use of biomass has been limited by its low energy content and density, high moisture content, inconsistent configuration and decay characteristics. If biomass is upgraded by conventional methods, the cost of the fuel becomes prohibitive. Altex has identified a process, called the Altex Fuel Pellet (AFP) process, that utilizes a mixture of biomass wastes, including municipal biosolids, and some coal fines, to produce a strong, high energy content, good burning and weather resistant fuel pellet, that is lower in cost than coal. This cost benefit is primarily derived from fees that are collected for accepting municipal biosolids. Besides low cost, the process is also flexible and can incorporate several biomass materials of interest The work reported on herein showed the technical and economic feasibility of the AFP process. Low-cost sawdust wood waste and light fractions of municipal wastes were selected as key biomass wastes to be combined with biosolids and coal fines to produce AFP pellets. The process combines steps of dewatering, pellet extrusion, drying and weatherizing. Prior to pilot-scale tests, bench-scale test equipment was used to produce limited quantities of pellets for characterization. These tests showed which pellet formulations had a high potential. Pilot-scale tests then showed that extremely robust pellets could be produced that have high energy content, good density and adequate weatherability. It was concluded that these pellets could be handled, stored and transported using equipment similar to that used for coal. Tests showed that AFP pellets have a high combustion rate when burned in a stoker type systems. While NOx emissions under stoker type firing conditions was high, a simple air staging approach reduced emissions to below that for coal. In pulverized-fuel-fired tests it was

  11. The variation of acute treatment costs of trauma in high-income countries

    Directory of Open Access Journals (Sweden)

    Willenberg Lynsey

    2012-08-01

    Full Text Available Abstract Background In order to assist health service planning, understanding factors that influence higher trauma treatment costs is essential. The majority of trauma costing research reports the cost of trauma from the perspective of the receiving hospital. There has been no comprehensive synthesis and little assessment of the drivers of cost variation, such as country, trauma, subgroups and methods. The aim of this review is to provide a synthesis of research reporting the trauma treatment costs and factors associated with higher treatment costs in high income countries. Methods A systematic search for articles relating to the cost of acute trauma care was performed and included studies reporting injury severity scores (ISS, per patient cost/charge estimates; and costing methods. Cost and charge values were indexed to 2011 cost equivalents and converted to US dollars using purchasing power parities. Results A total of twenty-seven studies were reviewed. Eighty-one percent of these studies were conducted in high income countries including USA, Australia, Europe and UK. Studies either reported a cost (74.1% or charge estimate (25.9% for the acute treatment of trauma. Across studies, the median per patient cost of acute trauma treatment was $22,448 (IQR: $11,819-$33,701. However, there was variability in costing methods used with 18% of studies providing comprehensive cost methods. Sixty-three percent of studies reported cost or charge items incorporated in their cost analysis and 52% reported items excluded in their analysis. In all publications reviewed, predictors of cost included Injury Severity Score (ISS, surgical intervention, hospital and intensive care, length of stay, polytrauma and age. Conclusion The acute treatment cost of trauma is higher than other disease groups. Research has been largely conducted in high income countries and variability exists in reporting costing methods as well as the actual costs. Patient populations studied

  12. The variation of acute treatment costs of trauma in high-income countries.

    Science.gov (United States)

    Willenberg, Lynsey; Curtis, Kate; Taylor, Colman; Jan, Stephen; Glass, Parisa; Myburgh, John

    2012-08-21

    In order to assist health service planning, understanding factors that influence higher trauma treatment costs is essential. The majority of trauma costing research reports the cost of trauma from the perspective of the receiving hospital. There has been no comprehensive synthesis and little assessment of the drivers of cost variation, such as country, trauma, subgroups and methods. The aim of this review is to provide a synthesis of research reporting the trauma treatment costs and factors associated with higher treatment costs in high income countries. A systematic search for articles relating to the cost of acute trauma care was performed and included studies reporting injury severity scores (ISS), per patient cost/charge estimates; and costing methods. Cost and charge values were indexed to 2011 cost equivalents and converted to US dollars using purchasing power parities. A total of twenty-seven studies were reviewed. Eighty-one percent of these studies were conducted in high income countries including USA, Australia, Europe and UK. Studies either reported a cost (74.1%) or charge estimate (25.9%) for the acute treatment of trauma. Across studies, the median per patient cost of acute trauma treatment was $22,448 (IQR: $11,819-$33,701). However, there was variability in costing methods used with 18% of studies providing comprehensive cost methods. Sixty-three percent of studies reported cost or charge items incorporated in their cost analysis and 52% reported items excluded in their analysis. In all publications reviewed, predictors of cost included Injury Severity Score (ISS), surgical intervention, hospital and intensive care, length of stay, polytrauma and age. The acute treatment cost of trauma is higher than other disease groups. Research has been largely conducted in high income countries and variability exists in reporting costing methods as well as the actual costs. Patient populations studied and the cost methods employed are the primary drivers for the

  13. Novel Low Cost Organic Vapor Jet Printing of Striped High Efficiency Phosphorescent OLEDs for White Lighting

    Energy Technology Data Exchange (ETDEWEB)

    Mike Hack

    2008-12-31

    shaped features. As a result, we believe that this work will lead to the development of a cost-effective manufacturing solution to produce very-high efficiency OLEDs. By comparison to more common ink-jet printing (IJP), OVJP can also produce well-defined patterns without the need to pattern the substrate with ink wells or to dry/anneal the ink. In addition, the material set is not limited by viscosity and solvent solubility. During the program we successfully demonstrated a 6-inch x 6-inch PHOLED lighting panel consisting of fine-featured red, green and blue (R-G-B) stripes (1mm width) using an OVJP deposition system that was designed, procured and installed into UDC's cleanroom as part of this program. This project will significantly accelerate the DOE's ability to meet its 2015 DOE SSL targets of 70-150 lumens/Watt and less than $10 per 1,000 lumens for high CRI lighting index (76-90). Coupled with a low cost manufacturing path through OVJP, we expect that this achievement will enable the DOE to achieve its 2015 performance goals by the year 2013, two years ahead of schedule. As shown by the technical work performed under this program, we believe that OVJP is a very promising technology to produce low cost, high efficacy, color tunable light sources. While we have made significant progress to develop OVJP technology and build a pilot line tool to study basic aspects of the technology and demonstrate a lighting panel prototype, further work needs to be performed before its full potential and commercial viability can be fully assessed.

  14. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Science.gov (United States)

    2010-10-01

    ... direction; budgeting, accounting, and auditing; and management of purchasing, property, payroll and... costs are those costs related to the overall management of the program. These costs can be in both the personnel and non-personnel categories. (2) Grantees must charge the costs of organization-wide management...

  15. 45 CFR 2521.45 - What are the limitations on the Federal government's share of program costs?

    Science.gov (United States)

    2010-10-01

    ...) Your share of member support costs must be non-Federal cash. (4) The Corporation's share of health care... administration costs. (1) You may provide your share of program operating costs with cash, including other...'s share of program costs? 2521.45 Section 2521.45 Public Welfare Regulations Relating to Public...

  16. A Low-Cost Neutral Zinc-Iron Flow Battery with High Energy Density for Stationary Energy Storage.

    Science.gov (United States)

    Xie, Congxin; Duan, Yinqi; Xu, Wenbin; Zhang, Huamin; Li, Xianfeng

    2017-11-20

    Flow batteries (FBs) are one of the most promising stationary energy-storage devices for storing renewable energy. However, commercial progress of FBs is limited by their high cost and low energy density. A neutral zinc-iron FB with very low cost and high energy density is presented. By using highly soluble FeCl 2 /ZnBr 2 species, a charge energy density of 56.30 Wh L -1 can be achieved. DFT calculations demonstrated that glycine can combine with iron to suppress hydrolysis and crossover of Fe 3+ /Fe 2+ . The results indicated that an energy efficiency of 86.66 % can be obtained at 40 mA cm -2 and the battery can run stably for more than 100 cycles. Furthermore, a low-cost porous membrane was employed to lower the capital cost to less than $ 50 per kWh, which was the lowest value that has ever been reported. Combining the features of low cost, high energy density and high energy efficiency, the neutral zinc-iron FB is a promising candidate for stationary energy-storage applications. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Preliminary estimates of cost savings for defense high level waste vitrification options

    International Nuclear Information System (INIS)

    Merrill, R.A.; Chapman, C.C.

    1993-09-01

    The potential for realizing cost savings in the disposal of defense high-level waste through process and design modificatins has been considered. Proposed modifications range from simple changes in the canister design to development of an advanced melter capable of processing glass with a higher waste loading. Preliminary calculations estimate the total disposal cost (not including capital or operating costs) for defense high-level waste to be about $7.9 billion dollars for the reference conditions described in this paper, while projected savings resulting from the proposed process and design changes could reduce the disposal cost of defense high-level waste by up to $5.2 billion

  18. Cost of Mastitis in Scottish Dairy Herds with Low and High Subclinical Mastitis Problems

    OpenAIRE

    YALÇIN, Cengiz

    2000-01-01

    The aim of this study was to estimate the cost of mastitis and the contribution of each cost component of mastitis to the total mastitis induced cost in herds with low and high levels of subclinical mastitis under Scottish field conditions. It was estimated that mastitis cost £140 per cow/year to the average Scottish dairy farmer in 1996. However, this figure was as low as £69 per cow/year in herds with lower levels of subclinical mastitis, and as high as £228 cow/year in herds with high s...

  19. Low Cost High Performance Nanostructured Spectrally Selective Coating

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Sungho [Univ. of California, San Diego, CA (United States)

    2017-04-05

    Sunlight absorbing coating is a key enabling technology to achieve high-temperature high-efficiency concentrating solar power operation. A high-performance solar absorbing material must simultaneously meet all the following three stringent requirements: high thermal efficiency (usually measured by figure of merit), high-temperature durability, and oxidation resistance. The objective of this research is to employ a highly scalable process to fabricate and coat black oxide nanoparticles onto solar absorber surface to achieve ultra-high thermal efficiency. Black oxide nanoparticles have been synthesized using a facile process and coated onto absorber metal surface. The material composition, size distribution and morphology of the nanoparticle are guided by numeric modeling. Optical and thermal properties have been both modeled and measured. High temperature durability has been achieved by using nanocomposites and high temperature annealing. Mechanical durability on thermal cycling have also been investigated and optimized. This technology is promising for commercial applications in next-generation high-temperature concentration solar power (CSP) plants.

  20. A Low-Cost Time-Hopping Impulse Radio System for High Data Rate Transmission

    Directory of Open Access Journals (Sweden)

    Jinyun Zhang

    2005-03-01

    Full Text Available We present an efficient, low-cost implementation of time-hopping impulse radio that fulfills the spectral mask mandated by the FCC and is suitable for high-data-rate, short-range communications. Key features are (i all-baseband implementation that obviates the need for passband components, (ii symbol-rate (not chip rate sampling, A/D conversion, and digital signal processing, (iii fast acquisition due to novel search algorithms, and (iv spectral shaping that can be adapted to accommodate different spectrum regulations and interference environments. Computer simulations show that this system can provide 110 Mbps at 7–10 m distance, as well as higher data rates at shorter distances under FCC emissions limits. Due to the spreading concept of time-hopping impulse radio, the system can sustain multiple simultaneous users, and can suppress narrowband interference effectively.

  1. Low cost, low tech SNP genotyping tools for resource-limited areas: Plague in Madagascar as a model.

    Directory of Open Access Journals (Sweden)

    Cedar L Mitchell

    2017-12-01

    financial cost for resource constraint laboratories. This is a practical formula that reduces resource-driven limitations to genetic research and promises to advance global collective knowledge of infectious diseases emanating from resource limited regions of the world.

  2. Training Physicians to Provide High-Value, Cost-Conscious Care A Systematic Review

    NARCIS (Netherlands)

    Stammen, L.A.; Stalmeijer, R.E.; Paternotte, E.; Pool, A.O.; Driessen, E.W.; Scheele, F.; Stassen, L.P.S.

    2015-01-01

    Importance Increasing health care expenditures are taxing the sustainability of the health care system. Physicians should be prepared to deliver high-value, cost-conscious care. Objective To understand the circumstances in which the delivery of high-value, cost-conscious care is learned, with a goal

  3. Costs and limits of dosage response to predation risk: to what extent can tadpoles invest in anti-predator morphology?

    Science.gov (United States)

    Teplitsky, Céline; Plénet, Sandrine; Joly, Pierre

    2005-09-01

    Inducible defences have long been considered as a polyphenism opposing defended and undefended morphs. However, in nature, preys are exposed to various levels of predation risk and scale their investment in defence to actual predation risk. Still, among the traits that are involved in the defence, some are specific to one predator type while others act as a more generalised defence. The existence of defence costs could prevent an individual investing in all these traits simultaneously. In this study, we investigate the impact of an increasing level of predator density (stickleback, Gasterosteus aculeatus) on the expression of morphological inducible defences in tadpoles of Rana dalmatina. In this species, investment in tail length and tail muscle is a stickleback-specific response while increased tail fin depth is a more general defence. As expected, we found a relationship between investment in defence and level of risk through the responses of tail fin depth and tail length. We also found an exponential increase of defence cost, notably expressed by convex decrease of growth and developmental rates. We found a relative independence of investment in the different traits that compose the defence, revealing a high potential for fine tuning the expression of defended phenotypes with respect to local ecological conditions.

  4. High-value, cost-conscious health care: concepts for clinicians to evaluate the benefits, harms, and costs of medical interventions.

    Science.gov (United States)

    Owens, Douglas K; Qaseem, Amir; Chou, Roger; Shekelle, Paul

    2011-02-01

    Health care costs in the United States are increasing unsustainably, and further efforts to control costs are inevitable and essential. Efforts to control expenditures should focus on the value, in addition to the costs, of health care interventions. Whether an intervention provides high value depends on assessing whether its health benefits justify its costs. High-cost interventions may provide good value because they are highly beneficial; conversely, low-cost interventions may have little or no value if they provide little benefit. Thus, the challenge becomes determining how to slow the rate of increase in costs while preserving high-value, high-quality care. A first step is to decrease or eliminate care that provides no benefit and may even be harmful. A second step is to provide medical interventions that provide good value: medical benefits that are commensurate with their costs. This article discusses 3 key concepts for understanding how to assess the value of health care interventions. First, assessing the benefits, harms, and costs of an intervention is essential to understand whether it provides good value. Second, assessing the cost of an intervention should include not only the cost of the intervention itself but also any downstream costs that occur because the intervention was performed. Third, the incremental cost-effectiveness ratio estimates the additional cost required to obtain additional health benefits and provides a key measure of the value of a health care intervention.

  5. Improvement of the cost-benefit analysis algorithm for high-rise construction projects

    Directory of Open Access Journals (Sweden)

    Gafurov Andrey

    2018-01-01

    Full Text Available The specific nature of high-rise investment projects entailing long-term construction, high risks, etc. implies a need to improve the standard algorithm of cost-benefit analysis. An improved algorithm is described in the article. For development of the improved algorithm of cost-benefit analysis for high-rise construction projects, the following methods were used: weighted average cost of capital, dynamic cost-benefit analysis of investment projects, risk mapping, scenario analysis, sensitivity analysis of critical ratios, etc. This comprehensive approach helped to adapt the original algorithm to feasibility objectives in high-rise construction. The authors put together the algorithm of cost-benefit analysis for high-rise construction projects on the basis of risk mapping and sensitivity analysis of critical ratios. The suggested project risk management algorithms greatly expand the standard algorithm of cost-benefit analysis in investment projects, namely: the “Project analysis scenario” flowchart, improving quality and reliability of forecasting reports in investment projects; the main stages of cash flow adjustment based on risk mapping for better cost-benefit project analysis provided the broad range of risks in high-rise construction; analysis of dynamic cost-benefit values considering project sensitivity to crucial variables, improving flexibility in implementation of high-rise projects.

  6. Improvement of the cost-benefit analysis algorithm for high-rise construction projects

    Science.gov (United States)

    Gafurov, Andrey; Skotarenko, Oksana; Plotnikov, Vladimir

    2018-03-01

    The specific nature of high-rise investment projects entailing long-term construction, high risks, etc. implies a need to improve the standard algorithm of cost-benefit analysis. An improved algorithm is described in the article. For development of the improved algorithm of cost-benefit analysis for high-rise construction projects, the following methods were used: weighted average cost of capital, dynamic cost-benefit analysis of investment projects, risk mapping, scenario analysis, sensitivity analysis of critical ratios, etc. This comprehensive approach helped to adapt the original algorithm to feasibility objectives in high-rise construction. The authors put together the algorithm of cost-benefit analysis for high-rise construction projects on the basis of risk mapping and sensitivity analysis of critical ratios. The suggested project risk management algorithms greatly expand the standard algorithm of cost-benefit analysis in investment projects, namely: the "Project analysis scenario" flowchart, improving quality and reliability of forecasting reports in investment projects; the main stages of cash flow adjustment based on risk mapping for better cost-benefit project analysis provided the broad range of risks in high-rise construction; analysis of dynamic cost-benefit values considering project sensitivity to crucial variables, improving flexibility in implementation of high-rise projects.

  7. When it is costly to have a caring mother: food limitation erases the benefits of parental care in earwigs.

    Science.gov (United States)

    Meunier, Joël; Kölliker, Mathias

    2012-08-23

    The aggregation of parents with offspring is generally associated with different forms of care that improve offspring survival at potential costs to parents. Under poor environments, the limited amount of resources available can increase the level of competition among family members and consequently lead to adaptive changes in parental investment. However, it remains unclear as to what extent such changes modify offspring fitness, particularly when offspring can survive without parents such as in the European earwig, Forficula auricularia. Here, we show that under food restriction, earwig maternal presence decreased offspring survival until adulthood by 43 per cent. This effect was independent of sibling competition and was expressed after separation from the female, indicating lasting detrimental effects. The reduced benefits of maternal presence on offspring survival were not associated with higher investment in future reproduction, suggesting a condition-dependent effect of food restriction on mothers and local mother-offspring competition for food. Overall, these findings demonstrate for the first time a long-term negative effect of maternal presence on offspring survival in a species with maternal care, and highlight the importance of food availability in the early evolution of family life.

  8. Mobility at any cost? Necessity and limits. Pt. 1; Mobilitaet um jeden Preis? Notwendigkeit und Grenzen. T. 1

    Energy Technology Data Exchange (ETDEWEB)

    Assmann, G. [comp.; Froese, B. [comp.; Haury, H.J. [comp.; Jahn, T. [comp.

    1996-06-01

    On 27 June 1996, the `Information Umwelt` organisation held a seminar for journalists in Munich under the title `Mobility at any cost? Necessity and limits`. In industrial societies, mobility is defined as a basic need. The contributions compiled in the present volume are basically transcripts of the lectures held at the meeting. Their titles are as follows: Mobility for tomorrow - problems, requirements,possible solutions; California dreaming? - new framework conditions for tomorrow`s mobility; Mobility as a success strategy - who falls by the wayside?; Climate and transport; Pollutants from road traffic and breathing trouble in children; Transport development in a developing country: The example of the People`s Republic of China; The fuel cell in mobile use. (orig/RHM) [Deutsch] `Mobilitaet um jeden Preis? Notwendigkeit und Grenzen` hiess das Thema des Journalistenseminars, das die Information Umwelt am 27.6.1966 in Muenchen veranstaltete. Mobilitaet wird in der Industriegesellschaft als Grundbeduerfnis definiert. Bei den Beitraegen handelt es sich im wesentlichen um schriftliche Ausarbeitungen der Referenten zu den Themen: Mobilitaet fuer morten - Probleme, Anforderungen, Loesungsansaetze; California Dreaming? - Neue Rahmenbedingungen fuer die Mobilitaet von morgen; Erfolgsprinzip Fortbewegung - wer bleibt auf der Strecke?; Klima und Verkehr; Schadstoffe aus dem Strassenverkehr; Verkehrsentwicklung in einem Entwicklungsland - Das Beispiel der Volksrepublik China; Die Brennstoffzelle im mobilen Einsatz. (orig./RHM)

  9. Social cost of heavy drinking and alcohol dependence in high-income countries.

    Science.gov (United States)

    Mohapatra, Satya; Patra, Jayadeep; Popova, Svetlana; Duhig, Amy; Rehm, Jürgen

    2010-06-01

    A comprehensive review of cost drivers associated with alcohol abuse, heavy drinking, and alcohol dependence for high-income countries was conducted. The data from 14 identified cost studies were tabulated according to the potential direct and indirect cost drivers. The costs associated with alcohol abuse, alcohol dependence, and heavy drinking were calculated. The weighted average of the total societal cost due to alcohol abuse as percent gross domestic product (GDP)--purchasing power parity (PPP)--was 1.58%. The cost due to heavy drinking and/or alcohol dependence as percent GDP (PPP) was estimated to be 0.96%. On average, the alcohol-attributable indirect cost due to loss of productivity is more than the alcohol-attributable direct cost. Most of the countries seem to incur 1% or more of their GDP (PPP) as alcohol-attributable costs, which is a high toll for a single factor and an enormous burden on public health. The majority of alcohol-attributable costs incurred as a consequence of heavy drinking and/or alcohol dependence. Effective prevention and treatment measures should be implemented to reduce these costs.

  10. High Performance Low Cost Digitally Controlled Power Conversion Technology

    DEFF Research Database (Denmark)

    Jakobsen, Lars Tønnes

    2008-01-01

    in order to reduce the power consumption of servers and datacenters. The work presented in this thesis includes digital control methods for switch-mode converters implemented in microcontrollers, digital signal controllers and field programmable gate arrays. Microcontrollers are cheap devices that can...... be used for real-time control of switch-mode converters. Software design in the assembly language of the microcontroller is important because of the limited resources of the microcontroller. Microcontrollers are best suited for power electronics applications with low bandwidth requirements because...... the execution time of the software algorithm that realises the digital control law will constitute a considerable delay in the control loop. Digital signal controllers are powerful devices capable of performing arithmetic functions much faster than a microcontroller can. Digital signal controllers are well...

  11. Low-Cost Ultra-High Spatial and Temporal Resolution Mapping of Intertidal Rock Platforms

    Science.gov (United States)

    Bryson, M.; Johnson-Roberson, M.; Murphy, R.

    2012-07-01

    Intertidal ecosystems have primarily been studied using field-based sampling; remote sensing offers the ability to collect data over large areas in a snapshot of time which could compliment field-based sampling methods by extrapolating them into the wider spatial and temporal context. Conventional remote sensing tools (such as satellite and aircraft imaging) provide data at relatively course, sub-meter resolutions or with limited temporal resolutions and relatively high costs for small-scale environmental science and ecology studies. In this paper, we describe a low-cost, kite-based imaging system and photogrammetric pipeline that was developed for constructing highresolution, 3D, photo-realistic terrain models of intertidal rocky shores. The processing pipeline uses automatic image feature detection and matching, structure-from-motion and photo-textured terrain surface reconstruction algorithms that require minimal human input and only a small number of ground control points and allow the use of cheap, consumer-grade digital cameras. The resulting maps combine colour and topographic information at sub-centimeter resolutions over an area of approximately 100m, thus enabling spatial properties of the intertidal environment to be determined across a hierarchy of spatial scales. Results of the system are presented for an intertidal rock platform at Cape Banks, Sydney, Australia. Potential uses of this technique include mapping of plant (micro- and macro-algae) and animal (e.g. gastropods) assemblages at multiple spatial and temporal scales.

  12. Universality of the high-temperature viscosity limit of silicate liquids

    DEFF Research Database (Denmark)

    Zheng, Qiuju; Mauro, John C.; Ellison, Adam J.

    2011-01-01

    We investigate the high-temperature limit of liquid viscosity by analyzing measured viscosity curves for 946 silicate liquids and 31 other liquids including metallic, molecular, and ionic systems. Our results show no systematic dependence of the high-temperature viscosity limit on chemical...... composition for the studied liquids. Based on theMauro-Yue-Ellison-Gupta-Allan (MYEGA) model of liquid viscosity, the high-temperature viscosity limit of silicate liquids is 10−2.93 Pa·s. Having established this value, there are only two independent parameters governing the viscosity-temperature relation...

  13. A high dutycycle low cost multichannel analyser for electron spectroscopy

    International Nuclear Information System (INIS)

    Norell, K.E.; Baltzer, P.

    1983-03-01

    A high dutycycle multichannel analyzer has been designed and used in time-of-flight electron spectroscopy. The memory capacity is 64k counts. The number of channels is 8192 with a time resolution of 100 ns. An oscilloscope is used to display the spectra synchronous with the counting. The unit has been built with standard electronic components. (author)

  14. Calculus in High School--At What Cost?

    Science.gov (United States)

    Sorge, D. H.; Wheatley, G. H.

    1977-01-01

    Evidence on the decline in preparation of entering calculus students and the relationship to high school preparation is presented, focusing on the trend toward the de-emphasis of trigonometry and analytic geometry in favor of calculus. Data on students' perception of the adequacy of their preparation are also presented. (Author/MN)

  15. Low-Cost, High-Performance Hall Thruster Support System

    Science.gov (United States)

    Hesterman, Bryce

    2015-01-01

    Colorado Power Electronics (CPE) has built an innovative modular PPU for Hall thrusters, including discharge, magnet, heater and keeper supplies, and an interface module. This high-performance PPU offers resonant circuit topologies, magnetics design, modularity, and a stable and sustained operation during severe Hall effect thruster current oscillations. Laboratory testing has demonstrated discharge module efficiency of 96 percent, which is considerably higher than current state of the art.

  16. 14 CFR 101.25 - Operating limitations for Class 2-High Power Rockets and Class 3-Advanced High Power Rockets.

    Science.gov (United States)

    2010-01-01

    ... Power Rockets and Class 3-Advanced High Power Rockets. 101.25 Section 101.25 Aeronautics and Space... OPERATING RULES MOORED BALLOONS, KITES, AMATEUR ROCKETS AND UNMANNED FREE BALLOONS Amateur Rockets § 101.25 Operating limitations for Class 2-High Power Rockets and Class 3-Advanced High Power Rockets. When operating...

  17. 40 CFR Table 3 to Subpart Eeee of... - Operating Limits-High Throughput Transfer Racks

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits-High Throughput Transfer Racks 3 Table 3 to Subpart EEEE of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION... Throughput Transfer Racks As stated in § 63.2346(e), you must comply with the operating limits for existing...

  18. Comparison of Liquid Limit of Highly Plastic Clay by Means of Casagrande and Fall Cone Apparatus

    DEFF Research Database (Denmark)

    Grønbech, Gitte Lyng; Nielsen, Benjaminn Nordahl; Ibsen, Lars Bo

    2011-01-01

    The connection between the Liquid Limit found using the Casagrande and the Fall Cone Apparatus is tested for the Danish Eocene Clay that has Liquid Limits up to 350% and Plasticity Index up to 300%, which is well outside the normal range of Casagrande’s Plasticity Chart. Based on the high plastic...

  19. Integrated cost estimation methodology to support high-performance building design

    Energy Technology Data Exchange (ETDEWEB)

    Vaidya, Prasad; Greden, Lara; Eijadi, David; McDougall, Tom [The Weidt Group, Minnetonka (United States); Cole, Ray [Axiom Engineers, Monterey (United States)

    2007-07-01

    Design teams evaluating the performance of energy conservation measures (ECMs) calculate energy savings rigorously with established modelling protocols, accounting for the interaction between various measures. However, incremental cost calculations do not have a similar rigor. Often there is no recognition of cost reductions with integrated design, nor is there assessment of cost interactions amongst measures. This lack of rigor feeds the notion that high-performance buildings cost more, creating a barrier for design teams pursuing aggressive high-performance outcomes. This study proposes an alternative integrated methodology to arrive at a lower perceived incremental cost for improved energy performance. The methodology is based on the use of energy simulations as means towards integrated design and cost estimation. Various points along the spectrum of integration are identified and characterized by the amount of design effort invested, the scheduling of effort, and relative energy performance of the resultant design. It includes a study of the interactions between building system parameters as they relate to capital costs. Several cost interactions amongst energy measures are found to be significant.The value of this approach is demonstrated with alternatives in a case study that shows the differences between perceived costs for energy measures along various points on the integration spectrum. These alternatives show design tradeoffs and identify how decisions would have been different with a standard costing approach. Areas of further research to make the methodology more robust are identified. Policy measures to encourage the integrated approach and reduce the barriers towards improved energy performance are discussed.

  20. Utility of the heteroduplex assay (HDA) as a simple and cost-effective tool for the identification of HIV type 1 dual infections in resource-limited settings.

    Science.gov (United States)

    Powell, Rebecca L R; Urbanski, Mateusz M; Burda, Sherri; Nanfack, Aubin; Kinge, Thompson; Nyambi, Phillipe N

    2008-01-01

    The predominance of unique recombinant forms (URFs) of HIV-1 in Cameroon suggests that dual infection, the concomitant or sequential infection with genetically distinct HIV-1 strains, occurs frequently in this region; yet, identifying dual infection among large HIV cohorts in local, resource-limited settings is uncommon, since this generally relies on labor-intensive and costly sequencing methods. Consequently, there is a need to develop an effective, cost-efficient method appropriate to the developing world to identify these infections. In the present study, the heteroduplex assay (HDA) was used to verify dual or single infection status, as shown by traditional sequence analysis, for 15 longitudinally sampled study subjects from Cameroon. Heteroduplex formation, indicative of a dual infection, was identified for all five study subjects shown by sequence analysis to be dually infected. Conversely, heteroduplex formation was not detectable for all 10 HDA reactions of the singly infected study subjects. These results suggest that the HDA is a simple yet powerful and inexpensive tool for the detection of both intersubtype and intrasubtype dual infections, and that the HDA harbors significant potential for reliable, high-throughput screening for dual infection. As these infections and the recombinants they generate facilitate leaps in HIV-1 evolution, and may present major challenges for treatment and vaccine design, this assay will be critical for monitoring the continuing pandemic in regions of the world where HIV-1 viral diversity is broad.

  1. High-speed photographic observation of plasma-limiter interactions in ISX-B

    International Nuclear Information System (INIS)

    Clausing, R.E.; Emerson, L.C.; Heatherly, L.

    1981-01-01

    High-speed motion pictures confirm that arcing occurs during periods of plasma instability in ISX-B. Various types of plasma-limiter interactions are described and illustrated. Arcing and other visible phenomena are correlated to plasma parameters

  2. Testing the black disk limit in $pp$ collisions at very high energy

    OpenAIRE

    Brogueira, P.; de Deus, J. Dias

    2011-01-01

    We use geometric scaling invariant quantities to measure the approach, or not, of the imaginary and real parts of the elastic scattering amplitude, to the black disk limit, in $pp$ collisions at very high energy.

  3. Transformational Electronics: Towards Flexible Low-Cost High Mobility Channel Materials

    KAUST Repository

    Nassar, Joanna M.

    2014-05-01

    For the last four decades, Si CMOS technology has been advancing with Moore’s law prediction, working itself down to the sub-20 nm regime. However, fundamental problems and limitations arise with the down-scaling of transistors and thus new innovations needed to be discovered in order to further improve device performance without compromising power consumption and size. Thus, a lot of studies have focused on the development of new CMOS compatible architectures as well as the discovery of new high mobility channel materials that will allow further miniaturization of CMOS transistors and improvement of device performance. Pushing the limits even further, flexible and foldable electronics seem to be the new attractive topic. By being able to make our devices flexible through a CMOS compatible process, one will be able to integrate hundreds of billions of more transistors in a small volumetric space, allowing to increase the performance and speed of our electronics all together with making things thinner, lighter, smaller and even interactive with the human skin. Thus, in this thesis, we introduce for the first time a cost-effective CMOS compatible approach to make high-k/metal gate devices on flexible Germanium (Ge) and Silicon-Germanium (SiGe) platforms. In the first part, we will look at the various approaches in the literature that has been developed to get flexible platforms, as well as we will give a brief overview about epitaxial growth of Si1-xGex films. We will also examine the electrical properties of the Si1-xGex alloys up to Ge (x=1) and discuss how strain affects the band structure diagram, and thus the mobility of the material. We will also review the material growth properties as well as the state-of-the-art results on high mobility metal-oxide semiconductor capacitors (MOSCAPs) using strained SiGe films. Then, we will introduce the flexible process that we have developed, based on a cost-effective “trench-protect-release-reuse” approach, utilizing

  4. Medicaid care management: description of high-cost addictions treatment clients.

    Science.gov (United States)

    Neighbors, Charles J; Sun, Yi; Yerneni, Rajeev; Tesiny, Ed; Burke, Constance; Bardsley, Leland; McDonald, Rebecca; Morgenstern, Jon

    2013-09-01

    High utilizers of alcohol and other drug treatment (AODTx) services are a priority for healthcare cost control. We examine characteristics of Medicaid-funded AODTx clients, comparing three groups: individuals cost clients in the top decile of AODTx expenditures (HC; n=5,718); and 1760 enrollees in a chronic care management (CM) program for HC clients implemented in 22 counties in New York State. Medicaid and state AODTx registry databases were combined to draw demographic, clinical, social needs and treatment history data. HC clients accounted for 49% of AODTx costs funded by Medicaid. As expected, HC clients had significant social welfare needs, comorbid medical and psychiatric conditions, and use of inpatient services. The CM program was successful in enrolling some high-needs, high-cost clients but faced barriers to reaching the most costly and disengaged individuals. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. Clinical and cost-effectiveness of internal limiting membrane peeling for patients with idiopathic full thickness macular hole. Protocol for a Randomised Controlled Trial: FILMS (Full-thickness macular hole and Internal Limiting Membrane peeling Study

    Directory of Open Access Journals (Sweden)

    Cook Jonathan

    2008-11-01

    Full Text Available Abstract Background A full-thickness macular hole (FTMH is a common retinal condition associated with impaired vision. Randomised controlled trials (RCTs have demonstrated that surgery, by means of pars plana vitrectomy and post-operative intraocular tamponade with gas, is effective for stage 2, 3 and 4 FTMH. Internal limiting membrane (ILM peeling has been introduced as an additional surgical manoeuvre to increase the success of the surgery; i.e. increase rates of hole closure and visual improvement. However, little robust evidence exists supporting the superiority of ILM peeling compared with no-peeling techniques. The purpose of FILMS (Full-thickness macular hole and Internal Limiting Membrane peeling Study is to determine whether ILM peeling improves the visual function, the anatomical closure of FTMH, and the quality of life of patients affected by this disorder, and the cost-effectiveness of the surgery. Methods/Design Patients with stage 2–3 idiopathic FTMH of less or equal than 18 months duration (based on symptoms reported by the participant and with a visual acuity ≤ 20/40 in the study eye will be enrolled in this FILMS from eight sites across the UK and Ireland. Participants will be randomised to receive combined cataract surgery (phacoemulsification and intraocular lens implantation and pars plana vitrectomy with postoperative intraocular tamponade with gas, with or without ILM peeling. The primary outcome is distance visual acuity at 6 months. Secondary outcomes include distance visual acuity at 3 and 24 months, near visual acuity at 3, 6, and 24 months, contrast sensitivity at 6 months, reading speed at 6 months, anatomical closure of the macular hole at each time point (1, 3, 6, and 24 months, health related quality of life (HRQOL at six months, costs to the health service and the participant, incremental costs per quality adjusted life year (QALY and adverse events. Discussion FILMS will provide high quality evidence on the

  6. Performance Limiting Flow Processes in High-State Loading High-Mach Number Compressors

    National Research Council Canada - National Science Library

    Tan, Choon S

    2008-01-01

    In high-stage loading high-Mach number (HLM) compressors, counter-rotating pairs of discrete vortices are shed at the trailing edge of the upstream blade row at a frequency corresponding to the downstream rotor blade passing frequency...

  7. Critical operations capabilities in a high cost environment: a multiple case study

    Science.gov (United States)

    Sansone, C.; Hilletofth, P.; Eriksson, D.

    2018-04-01

    Operations capabilities have been a popular research area for many years and several frameworks have been proposed in the literature. The current frameworks do not take specific contexts into consideration, for instance a high cost environment. This research gap is of particular interest since a manufacturing relocation process has been ongoing the last decades, leading to a huge amount of manufacturing being moved from high to low cost environments. The purpose of this study is to identify critical operations capabilities in a high cost environment. The two research questions were: What are the critical operations capabilities dimensions in a high cost environment? What are the critical operations capabilities in a high cost environment? A multiple case study was conducted and three Swedish manufacturing firms were selected. The study was based on the investigation of an existing framework of operations capabilities. The main dimensions of operations capabilities included in the framework were: cost, quality, delivery, flexibility, service, innovation and environment. Each of the dimensions included two or more operations capabilities. The findings confirmed the validity of the framework and its usefulness in a high cost environment and a new operations capability was revealed (employee flexibility).

  8. Effects of structure and defect on fatigue limit in high strength ductile irons

    International Nuclear Information System (INIS)

    Kim, Jin Hak; Kim, Min Gun

    2000-01-01

    In this paper, the influence of several factors such as hardness, internal defect and non-propagating crack on fatigue limits was investigated with three kinds of ductile iron specimens. From the experimental results the fatigue limits were examined in relation with hardness and tensile strength in case of high strength specimens under austempering treatment; in consequence the marked improvement of fatigue limits were not showed. The maximum defect size was an important factor to predict and to evaluate the fatigue limits of ductile irons. And, the quantitative relationship between the fatigue limits(σ ω ) and the maximum defect size(√area max ) was expressed as σ ω n · √area max =C 2 . Also, it was possible to explain the difference for the fatigue limits in three ductile irons by introduction of the non-propagating crack rates

  9. Empathy costs: Negative emotional bias in high empathisers.

    Science.gov (United States)

    Chikovani, George; Babuadze, Lasha; Iashvili, Nino; Gvalia, Tamar; Surguladze, Simon

    2015-09-30

    Excessive empathy has been associated with compassion fatigue in health professionals and caregivers. We investigated an effect of empathy on emotion processing in 137 healthy individuals of both sexes. We tested a hypothesis that high empathy may underlie increased sensitivity to negative emotion recognition which may interact with gender. Facial emotion stimuli comprised happy, angry, fearful, and sad faces presented at different intensities (mild and prototypical) and different durations (500ms and 2000ms). The parameters of emotion processing were represented by discrimination accuracy, response bias and reaction time. We found that higher empathy was associated with better recognition of all emotions. We also demonstrated that higher empathy was associated with response bias towards sad and fearful faces. The reaction time analysis revealed that higher empathy in females was associated with faster (compared with males) recognition of mildly sad faces of brief duration. We conclude that although empathic abilities were providing for advantages in recognition of all facial emotional expressions, the bias towards emotional negativity may potentially carry a risk for empathic distress. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. Bottom-Up Cost Analysis of a High Concentration PV Module; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    Horowitz, K.; Woodhouse, M.; Lee, H.; Smestad, G.

    2015-04-13

    We present a bottom-up model of III-V multi-junction cells, as well as a high concentration PV (HCPV) module. We calculate $0.65/Wp(DC) manufacturing costs for our model HCPV module design with today’s capabilities, and find that reducing cell costs and increasing module efficiency offer the promising pathways for future cost reductions. Cell costs could be significantly reduced via an increase in manufacturing scale, substrate reuse, and improved manufacturing yields. We also identify several other significant drivers of HCPV module costs, including the Fresnel lens primary optic, module housing, thermal management, and the receiver board. These costs could potentially be lowered by employing innovative module designs.

  11. Controlling Capital Costs in High Performance Office Buildings: A Review of Best Practices for Overcoming Cost Barriers

    Energy Technology Data Exchange (ETDEWEB)

    Pless, S.; Torcellini, P.

    2012-05-01

    This paper presents a set of 15 best practices for owners, designers, and construction teams of office buildings to reach high performance goals for energy efficiency, while maintaining a competitive budget. They are based on the recent experiences of the owner and design/build team for the Research Support Facility (RSF) on National Renewable Energy Facility's campus in Golden, CO, which show that achieving this outcome requires each key integrated team member to understand their opportunities to control capital costs.

  12. Evaluation of Risk Management Strategies for a Low-Cost, High-Risk Project

    Science.gov (United States)

    Shishko, Robert; Jorgensen, Edward J.

    1996-01-01

    This paper summarizes work in progress to define and implement a risk management process tailored to a low-cost, high-risk, NASA mission -the Microrover Flight Experiment (MFEX, commonly called the Mars microrover).

  13. A highly sensitive, low-cost, wearable pressure sensor based on conductive hydrogel spheres

    KAUST Repository

    Tai, Yanlong; Mulle, Matthieu; Ventura, Isaac Aguilar; Lubineau, Gilles

    2015-01-01

    Wearable pressure sensing solutions have promising future for practical applications in health monitoring and human/machine interfaces. Here, a highly sensitive, low-cost, wearable pressure sensor based on conductive single-walled carbon nanotube

  14. Very Low-Cost, Rugged, High-Vacuum System for Mass Spectrometers, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA, the DoD, DHS, and commercial industry have a pressing need for miniaturized, rugged, low-cost, high vacuum systems. Recent advances in sensor technology at...

  15. The hidden costs of installing xpert machines in a tuberculosis high ...

    African Journals Online (AJOL)

    The hidden costs of installing xpert machines in a tuberculosis high-burden country: experiences from Nigeria. Saddiq Tsimiri Abdurrahman, Nnamdi Emenyonu, Olusegun Joshua Obasanya, Lovett Lawson, Russell Dacombe, Muhammad Muhammad, Olanrewaju Oladimeji, Luis Eduardo Cuevas ...

  16. The cost of empathy : Parent-adolescent conflict predicts emotion dysregulation for highly empathic youth

    NARCIS (Netherlands)

    van Lissa, C.J.; Hawk, S.T.; Koot, Hans M.; Branje, S.J.T.; Meeus, W.H.J.

    Empathy plays a key role in maintaining close relationships and promoting prosocial conflict resolution. However, research has not addressed the potential emotional cost of adolescents' high empathy, particularly when relationships are characterized by more frequent conflict. The present 6-year

  17. Hummingbird - A Very Low Cost, High Delta V Spacecraft for Solar System Exploration, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Based on Microcosm's development of a high delta-V small Earth observation spacecraft called NanoEye, with a planned recurring cost of $2 million, Microcosm will...

  18. Cost optimization of load carrying thin-walled precast high performance concrete sandwich panels

    DEFF Research Database (Denmark)

    Hodicky, Kamil; Hansen, Sanne; Hulin, Thomas

    2015-01-01

    and HPCSP’s geometrical parameters as well as on material cost function in the HPCSP design. Cost functions are presented for High Performance Concrete (HPC), insulation layer, reinforcement and include labour-related costs. The present study reports the economic data corresponding to specific manufacturing......The paper describes a procedure to find the structurally and thermally efficient design of load-carrying thin-walled precast High Performance Concrete Sandwich Panels (HPCSP) with an optimal economical solution. A systematic optimization approach is based on the selection of material’s performances....... The solution of the optimization problem is performed in the computer package software Matlab® with SQPlab package and integrates the processes of HPCSP design, quantity take-off and cost estimation. The proposed optimization process outcomes in complex HPCSP design proposals to achieve minimum cost of HPCSP....

  19. Costs associated with implementation of a strict policy for controlling spread of highly resistant microorganisms in France.

    Science.gov (United States)

    Birgand, Gabriel; Leroy, Christophe; Nerome, Simone; Luong Nguyen, Liem Binh; Lolom, Isabelle; Armand-Lefevre, Laurence; Ciotti, Céline; Lecorre, Bertrand; Marcade, Géraldine; Fihman, Vincent; Nicolas-Chanoine, Marie-Hélène; Pelat, Camille; Perozziello, Anne; Fantin, Bruno; Yazdanpanah, Yazdan; Ricard, Jean-Damien; Lucet, Jean-Christophe

    2016-01-29

    To assess costs associated with implementation of a strict 'search and isolate' strategy for controlling highly drug-resistant organisms (HDRO). Review of data from 2-year prospective surveillance (01/2012 to 12/2013) of HDRO. Three university hospitals located in northern Paris. Episodes were defined as single cases or outbreaks of glycopeptide-resistant enterococci (GRE) or carbapenemase-producing Enterobacteriacae (CPE) colonisation. Costs were related to staff reinforcement, costs of screening cultures, contact precautions and interruption of new admissions. Univariate analysis, along with simple and multiple linear regression analyses, was conducted to determine variables associated with cost of HDRO management. Overall, 41 consecutive episodes were included, 28 single cases and 13 outbreaks. The cost (mean ± SD) associated with management of a single case identified within and/or 48 h after admission was €4443 ± 11,552 and €11,445 ± 15,743, respectively (pcost varied from €14,864 ± 17,734 for an episode with one secondary case (€7432 ± 8867 per case) to €136,525 ± 151,231 (€12,845 ± 5129 per case) when more than one secondary case occurred. In episodes of single cases, contact precautions and microbiological analyses represented 51% and 30% of overall cost, respectively. In outbreaks, cost related to interruption of new admissions represented 77-94% of total costs, and had the greatest financial impact (R(2)=0.98, pcostly measure in an outbreak situation. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  20. Re-Engineering a High Performance Electrical Series Elastic Actuator for Low-Cost Industrial Applications

    Directory of Open Access Journals (Sweden)

    Kenan Isik

    2017-01-01

    Full Text Available Cost is an important consideration when transferring a technology from research to industrial and educational use. In this paper, we introduce the design of an industrial grade series elastic actuator (SEA performed via re-engineering a research grade version of it. Cost-constrained design requires careful consideration of the key performance parameters for an optimal performance-to-cost component selection. To optimize the performance of the new design, we started by matching the capabilities of a high-performance SEA while cutting down its production cost significantly. Our posit was that performing a re-engineering design process on an existing high-end device will significantly reduce the cost without compromising the performance drastically. As a case study of design for manufacturability, we selected the University of Texas Series Elastic Actuator (UT-SEA, a high-performance SEA, for its high power density, compact design, high efficiency and high speed properties. We partnered with an industrial corporation in China to research the best pricing options and to exploit the retail and production facilities provided by the Shenzhen region. We succeeded in producing a low-cost industrial grade actuator at one-third of the cost of the original device by re-engineering the UT-SEA with commercial off-the-shelf components and reducing the number of custom-made parts. Subsequently, we conducted performance tests to demonstrate that the re-engineered product achieves the same high-performance specifications found in the original device. With this paper, we aim to raise awareness in the robotics community on the possibility of low-cost realization of low-volume, high performance, industrial grade research and education hardware.

  1. Using the Black Scholes method for estimating high cost illness insurance premiums in Colombia

    Directory of Open Access Journals (Sweden)

    Liliana Chicaíza

    2009-04-01

    Full Text Available This article applied the Black-Scholes option valuation formula to calculating high-cost illness reinsurance premiums in the Colombian health system. The coverage pattern used in reinsuring high-cost illnesses was replicated by means of a European call option contract. The option’s relevant variables and parameters were adapted to an insurance market context. The premium estimated by the BlackScholes method fell within the range of premiums estimated by the actuarial method.

  2. [Evolution of reimbursement of high-cost anticancer drugs: Financial impact within a university hospital].

    Science.gov (United States)

    Baudouin, Amandine; Fargier, Emilie; Cerruti, Ariane; Dubromel, Amélie; Vantard, Nicolas; Ranchon, Florence; Schwiertz, Vérane; Salles, Gilles; Souquet, Pierre-Jean; Thomas, Luc; Bérard, Frédéric; Nancey, Stéphane; Freyer, Gilles; Trillet-Lenoir, Véronique; Rioufol, Catherine

    2017-06-01

    In the context of health expenses control, reimbursement of high-cost medicines with a 'minor' or 'nonexistent' improvement in actual health benefit evaluated by the Haute Autorité de santé is revised by the decree of March 24, 2016 related to the procedure and terms of registration of high-cost pharmaceutical drugs. This study aims to set up the economic impact of this measure. A six months retrospective study was conducted within a French university hospital from July 1, 2015 to December 31, 2015. For each injectable high-cost anticancer drug prescribed to a patient with cancer, the therapeutic indication, its status in relation to the marketing authorization and the associated improvement in actual health benefit were examined. The total costs of these treatments, the cost per type of indication and, in the case of marketing authorization indications, the cost per improvement in actual health benefit were evaluated considering that all drugs affected by the decree would be struck off. Over six months, 4416 high-cost injectable anticancer drugs were prescribed for a total cost of 4.2 million euros. The costs of drugs with a minor or nonexistent improvement in actual benefit and which comparator is not onerous amount 557,564 euros. The reform of modalities of inscription on the list of onerous drugs represents a significant additional cost for health institutions (1.1 million euros for our hospital) and raises the question of the accessibility to these treatments for cancer patients. Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

  3. High-Pressure Limit Rate Rules for α-H Isomerization of Hydroperoxyalkylperoxy Radicals

    KAUST Repository

    Mohamed, Samah Y; Davis, Alexander Cory; Al Rashidi, Mariam J; Sarathy, Mani

    2018-01-01

    group. In this work, a combination of high level composite methods - CBS-QB3, G3 and G4 - is used to determine the high-pressure-limit rate parameters for the title reaction. Rate rules for H-migration reactions proceeding through 5-, 6-, 7- and 8

  4. Low-Cost Superconducting Wire for Wind Generators: High Performance, Low Cost Superconducting Wires and Coils for High Power Wind Generators

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-01-01

    REACT Project: The University of Houston will develop a low-cost, high-current superconducting wire that could be used in high-power wind generators. Superconducting wire currently transports 600 times more electric current than a similarly sized copper wire, but is significantly more expensive. The University of Houston’s innovation is based on engineering nanoscale defects in the superconducting film. This could quadruple the current relative to today’s superconducting wires, supporting the same amount of current using 25% of the material. This would make wind generators lighter, more powerful and more efficient. The design could result in a several-fold reduction in wire costs and enable their commercial viability of high-power wind generators for use in offshore applications.

  5. A high-temperature fiber sensor using a low cost interrogation scheme.

    Science.gov (United States)

    Barrera, David; Sales, Salvador

    2013-09-04

    Regenerated Fibre Bragg Gratings have the potential for high-temperature monitoring. In this paper, the inscription of Fibre Bragg Gratings (FBGs) and the later regeneration process to obtain Regenerated Fiber Bragg Gratings (RFBGs) in high-birefringence optical fiber is reported. The obtained RFBGs show two Bragg resonances corresponding to the slow and fast axis that are characterized in temperature terms. As the temperature increases the separation between the two Bragg resonances is reduced, which can be used for low cost interrogation. The proposed interrogation setup is based in the use of optical filters in order to convert the wavelength shift of each of the Bragg resonances into optical power changes. The design of the optical filters is also studied in this article. In first place, the ideal filter is calculated using a recursive method and defining the boundary conditions. This ideal filter linearizes the output of the interrogation setup but is limited by the large wavelength shift of the RFBG with temperature and the maximum attenuation. The response of modal interferometers as optical filters is also analyzed. They can be easily tuned shifting the optical spectrum. The output of the proposed interrogation scheme is simulated in these conditions improving the sensitivity.

  6. Fundamental understanding and development of low-cost, high-efficiency silicon solar cells

    Energy Technology Data Exchange (ETDEWEB)

    ROHATGI,A.; NARASIMHA,S.; MOSCHER,J.; EBONG,A.; KAMRA,S.; KRYGOWSKI,T.; DOSHI,P.; RISTOW,A.; YELUNDUR,V.; RUBY,DOUGLAS S.

    2000-05-01

    The overall objectives of this program are (1) to develop rapid and low-cost processes for manufacturing that can improve yield, throughput, and performance of silicon photovoltaic devices, (2) to design and fabricate high-efficiency solar cells on promising low-cost materials, and (3) to improve the fundamental understanding of advanced photovoltaic devices. Several rapid and potentially low-cost technologies are described in this report that were developed and applied toward the fabrication of high-efficiency silicon solar cells.

  7. Aspect Ratio Scaling of Ideal No-wall Stability Limits in High Bootstrap Fraction Tokamak Plasmas

    International Nuclear Information System (INIS)

    Menard, J.E.; Bell, M.G.; Bell, R.E.; Gates, D.A.; Kaye, S.M.; LeBlanc, B.P.; Maingi, R.; Sabbagh, S.A.; Soukhanovskii, V.; Stutman, D.

    2003-01-01

    Recent experiments in the low aspect ratio National Spherical Torus Experiment (NSTX) [M. Ono et al., Nucl. Fusion 40 (2000) 557] have achieved normalized beta values twice the conventional tokamak limit at low internal inductance and with significant bootstrap current. These experimental results have motivated a computational re-examination of the plasma aspect ratio dependence of ideal no-wall magnetohydrodynamic stability limits. These calculations find that the profile-optimized no-wall stability limit in high bootstrap fraction regimes is well described by a nearly aspect ratio invariant normalized beta parameter utilizing the total magnetic field energy density inside the plasma. However, the scaling of normalized beta with internal inductance is found to be strongly aspect ratio dependent at sufficiently low aspect ratio. These calculations and detailed stability analyses of experimental equilibria indicate that the nonrotating plasma no-wall stability limit has been exceeded by as much as 30% in NSTX in a high bootstrap fraction regime

  8. Retinopathy of prematurity: the high cost of screening regional and remote infants.

    Science.gov (United States)

    Yu, Tzu-Ying; Donovan, Tim; Armfield, Nigel; Gole, Glen A

    2018-01-25

    Demand for retinopathy of prematurity (ROP) screening is increasing for infants born at rural and regional hospitals where the service is not generally available. The health system cost for screening regional/remote infants has not been reported. The objective of this study is to evaluate the cost of ROP screening at a large centralized tertiary neonatal service for infants from regional/rural hospitals. This is a retrospective study to establish the cost of transferring regional/rural infants to the Royal Brisbane and Women's Hospital for ROP screening over a 28-month period. A total of 131 infants were included in this study. Individual infant costs were calculated from analysis of clinical and administrative records. Economic cost of ROP screening for all transfers from regional/rural hospitals to Royal Brisbane and Women's Hospital. The average economic cost of ROP screening for this cohort was AUD$5110 per infant screened and the total cost was AUD$669 413. The average cost per infant screened was highest for infants from a regional centre with a population of 75 000 (AUD$14 856 per child), which was also geographically furthest from Brisbane. No infant in this cohort transferred from a regional nursery reached criteria for intervention for ROP by standard guidelines. Health system costs for ROP screening of remote infants at a centralized hospital are high. Alternative strategies using telemedicine can now be compared with centralized screening. © 2018 Royal Australian and New Zealand College of Ophthalmologists.

  9. Considerations on a Cost Model for High-Field Dipole Arc Magnets for FCC

    CERN Document Server

    AUTHOR|(CDS)2078700; Durante, Maria; Lorin, Clement; Martinez, Teresa; Ruuskanen, Janne; Salmi, Tiina; Sorbi, Massimo; Tommasini, Davide; Toral, Fernando

    2017-01-01

    In the frame of the European Circular Collider (EuroCirCol), a conceptual design study for a post-Large Hadron Collider (LHC) research infrastructure based on an energy-frontier 100 TeV circular hadron collider [1]–[3], a cost model for the high-field dipole arc magnets is being developed. The aim of the cost model in the initial design phase is to provide the basis for sound strategic decisions towards cost effective designs, in particular: (A) the technological choice of superconducting material and its cost, (B) the target performance of Nb$_{3}$Sn superconductor, (C) the choice of operating temperature (D) the relevant design margins and their importance for cost, (E) the nature and extent of grading, and (F) the aperture’s influence on cost. Within the EuroCirCol study three design options for the high field dipole arc magnets are under study: cos − θ [4], block [5], and common-coil [6]. Here, in the advanced design phase, a cost model helps to (1) identify the cost drivers and feed-back this info...

  10. Considerations on a Cost Model for High-Field Dipole Arc Magnets for FCC

    CERN Document Server

    AUTHOR|(CDS)2078700; Durante, Maria; Lorin, Clement; Martinez, Teresa; Ruuskanen, Janne; Salmi, Tiina; Sorbi, Massimo; Tommasini, Davide; Toral, Fernando

    2017-01-01

    In the frame of the European Circular Collider (EuroCirCol), a conceptual design study for a post-Large Hadron Collider (LHC) research infrastructure based on an energy-frontier 100 TeV circular hadron collider [1]–[3], a cost model for the high-field dipole arc magnets is being developed. The aim of the cost model in the initial design phase is to provide the basis for sound strategic decisions towards cost effective designs, in particular: (A) the technological choice of superconducting material and its cost, (B) the target performance of Nb3Sn superconductor, (C) the choice of operating temperature (D) the relevant design margins and their importance for cost, (E) the nature and extent of grading, and (F) the aperture’s influence on cost. Within the EuroCirCol study three design options for the high field dipole arc magnets are under study: cos − θ [4], block [5], and common-coil [6]. Here, in the advanced design phase, a cost model helps to (1) identify the cost drivers and feed-back this informati...

  11. The Science of Cost-Effective Materials Design - A Study in the Development of a High Strength, Impact Resistant Steel

    Science.gov (United States)

    Abrahams, Rachel

    2017-06-01

    Intermediate alloy steels are widely used in applications where both high strength and toughness are required for extreme/dynamic loading environments. Steels containing greater than 10% Ni-Co-Mo are amongst the highest strength martensitic steels, due to their high levels of solution strengthening, and preservation of toughness through nano-scaled secondary hardening, semi-coherent hcp-M2 C carbides. While these steels have high yield strengths (σy 0.2 % >1200 MPa) with high impact toughness values (CVN@-40 >30J), they are often cost-prohibitive due to the material and processing cost of nickel and cobalt. Early stage-I steels such as ES-1 (Eglin Steel) were developed in response to the high cost of nickel-cobalt steels and performed well in extreme shock environments due to the presence of analogous nano-scaled hcp-Fe2.4 C epsilon carbides. Unfortunately, the persistence of W-bearing carbides limited the use of ES-1 to relatively thin sections. In this study, we discuss the background and accelerated development cycle of AF96, an alternative Cr-Mo-Ni-Si stage-I temper steel using low-cost heuristic and Integrated Computational Materials Engineering (ICME)-assisted methods. The microstructure of AF96 was tailored to mimic that of ES-1, while reducing stability of detrimental phases and improving ease of processing in industrial environments. AF96 is amenable to casting and forging, deeply hardenable, and scalable to 100,000 kg melt quantities. When produced at the industrial scale, it was found that AF96 exhibits near-statistically identical mechanical properties to ES-1 at 50% of the cost.

  12. Compressor motor for air conditioners realizing high efficiency and low cost; Kokoritsu tei cost wo jitsugenshita eakonyo asshukuki motor

    Energy Technology Data Exchange (ETDEWEB)

    Inaba, Y.; Kawamura, K.; Imazawa, K. [Toshiba Corp., Tokyo (Japan)

    2000-01-01

    The compressor motor accounts for most of the consumption of electric power in an air conditioner. To promote energy-saving, Toshiba has been progressively changing the compressor motors in its air conditioners to high-efficiency brushless DC motors. We have now developed a new compressor motor in order to achieve even greater energy-saving. A concentrated winding system was adopted featuring direct winding on the teeth of the stator core, for the first time in the industry. As a result, it was possible to realize a high-efficiency, compact, lightweight, and low-cost motor. Moreover, by constructing a new system for production, we were able to improve productivity and quality. The newly developed motor is expected to contribute to the further diffusion of energy-saving air conditioners. (author)

  13. High-energy neutrino background: Limitations on models of deuterium production

    International Nuclear Information System (INIS)

    Eichler, D.

    1979-01-01

    It is pointed out that Epstein's model for deuterium production via high-energy spallation reactions produces high-energy neutrinos in sufficient quantity to stand out above those that are produced by cosmic-ray interactions in the Earth's atmosphere. That the Reines experiment detected neutrinos of atmospheric origin without detecting any cosmic component restricts deuterium production by spallation reactions to very high redshifts (z> or approx. =300). Improved neutrino experiments may be able to push these limits back to recombination

  14. 13 CFR 107.855 - Interest rate ceiling and limitations on fees charged to Small Businesses (“Cost of Money”).

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Interest rate ceiling and... § 107.855 Interest rate ceiling and limitations on fees charged to Small Businesses (“Cost of Money... weighted average interest rate you pay on your “qualified borrowings”. “Qualified borrowings” means your...

  15. Investigation of Truck Size and Weight Limits - Technical Supplement. Vol. 7. Carrier, Market and Regional Cost and Energy Tradeoffs (pt. 1)

    Science.gov (United States)

    1982-01-01

    This study applied a systematic investigation of the range of benefits and costs to the U.S. economy and society as a whole, as well as to individual interest groups, resulting from a set of alternative changes to current Federal limits on truck size...

  16. Specialized surveillance for individuals at high risk for melanoma: a cost analysis of a high-risk clinic.

    Science.gov (United States)

    Watts, Caroline G; Cust, Anne E; Menzies, Scott W; Coates, Elliot; Mann, Graham J; Morton, Rachael L

    2015-02-01

    Regular surveillance of individuals at high risk for cutaneous melanoma improves early detection and reduces unnecessary excisions; however, a cost analysis of this specialized service has not been undertaken. To determine the mean cost per patient of surveillance in a high-risk clinic from the health service and societal perspectives. We used a bottom-up microcosting method to measure resource use in a consecutive sample of 102 patients treated in a high-risk hospital-based clinic in Australia during a 12-month period. Surveillance and treatment of melanoma. All surveillance and treatment procedures were identified through direct observation, review of medical records, and interviews with staff and were valued using scheduled fees from the Australian government. Societal costs included transportation and loss of productivity. The mean number of clinic visits per year was 2.7 (95% CI, 2.5-2.8) for surveillance and 3.8 (95% CI, 3.4-4.1) for patients requiring surgical excisions. The mean annual cost per patient to the health system was A $882 (95% CI, A $783-$982) (US $599 [95% CI, US $532-$665]); the cost discounted across 20 years was A $11,546 (95% CI, A $10,263-$12,829) (US $7839 [95% CI, US $6969-$8710]). The mean annual societal cost per patient (excluding health system costs) was A $972 (95% CI, A $899-$1045) (US $660 [95% CI, US $611-$710]); the cost discounted across 20 years was A $12,721 (95% CI, A $12,554-$14,463) (US $8637 [95% CI, US $8523-$9820]). Diagnosis of melanoma or nonmelanoma skin cancer and frequent excisions for benign lesions in a relatively small number of patients was responsible for positively skewed health system costs. Microcosting techniques provide an accurate cost estimate for the provision of a specialized service. The high societal cost reflects the time that patients are willing to invest to attend the high-risk clinic. This alternative model of care for a high-risk population has relevance for decision making about health policy.

  17. MONITORING HIGH-FREQUENCY OCEAN SIGNALS USING LOW-COST GNSS/IMU BUOYS

    Directory of Open Access Journals (Sweden)

    Y.-L. Huang

    2016-06-01

    Full Text Available In oceans there are different ocean signals covering the multi-frequencies including tsunami, meteotsunami, storm surge, as sea level change, and currents. These signals have the direct and significant impact on the economy and life of human-beings. Therefore, measuring ocean signals accurately becomes more and more important and necessary. Nowadays, there are many techniques and methods commonly used for monitoring oceans, but each has its limitation. For example, tide gauges only measure sea level relative to benchmarks and are disturbed unevenly, and satellite altimeter measurements are not continuous and inaccurate near coastal oceans. In addition, high-frequency ocean signals such as tsunami and meteotsunami cannot be sufficiently detected by 6-minutes tide gauge measurements or 10-day sampled altimetry data. Moreover, traditional accelerometer buoy is heavy, expensive and the low-frequency noise caused by the instrument is unavoidable. In this study, a small, low-cost and self-assembly autonomous Inertial Measurement Unit (IMU that independently collects continuous acceleration and angular velocity data is mounted on a GNSS buoy to provide the positions and tilts of the moving buoy. The main idea is to integrate the Differential GNSS (DGNSS or Precise Point Positioning (PPP solutions with IMU data, and then evaluate the performance by comparing with in situ tide gauges. The validation experiments conducted in the NCKU Tainan Hydraulics Laboratory showed that GNSS and IMU both can detect the simulated regular wave frequency and height, and the field experiments in the Anping Harbor, Tainan, Taiwan showed that the low-cost GNSS buoy has an excellent ability to observe significant wave heights in amplitude and frequency.

  18. Innovative High-Performance Deposition Technology for Low-Cost Manufacturing of OLED Lighting

    Energy Technology Data Exchange (ETDEWEB)

    Scott, David; Hamer, John

    2017-06-30

    In this project, OLEDWorks developed and demonstrated the innovative high-performance deposition technology required to deliver dramatic reductions in the cost of manufacturing OLED lighting in production equipment. The current high manufacturing cost of OLED lighting is the most urgent barrier to its market acceptance. The new deposition technology delivers solutions to the two largest parts of the manufacturing cost problem – the expense per area of good product for organic materials and for the capital cost and depreciation of the equipment. Organic materials cost is the largest expense item in the bill of materials and is predicted to remain so through 2020. The high-performance deposition technology developed in this project, also known as the next generation source (NGS), increases material usage efficiency from 25% found in current Gen2 deposition technology to 60%. This improvement alone results in a reduction of approximately $25/m2 of good product in organic materials costs, independent of production volumes. Additionally, this innovative deposition technology reduces the total depreciation cost from the estimated value of approximately $780/m2 of good product for state-of-the-art G2 lines (at capacity, 5-year straight line depreciation) to $170/m2 of good product from the OLEDWorks production line.

  19. Comparison of high-speed transportation systems in special consideration of investment costs

    Directory of Open Access Journals (Sweden)

    R. Schach

    2007-10-01

    Full Text Available In this paper a substantial comparison of different high-speed transportation systems and an approach to stochastic cost estimations are provided. Starting from the developments in Europe, the high-speed traffic technical characteristics of high-speed railways and Maglev systems are compared. But for a comprehensive comparison more criterions must be included and led to a wider consideration and the development of a multi-criteria comparison of high-speed transportation systems. In the second part a stochastic approach to cost estimations of infrastructure projects is encouraged. Its advantages in comparison with the traditional proceeding are presented and exemplify the practical implementation.

  20. High Cost/High Risk Components to Chalcogenide Molded Lens Model: Molding Preforms and Mold Technology

    Energy Technology Data Exchange (ETDEWEB)

    Bernacki, Bruce E.

    2012-10-05

    This brief report contains a critique of two key components of FiveFocal's cost model for glass compression molding of chalcogenide lenses for infrared applications. Molding preforms and mold technology have the greatest influence on the ultimate cost of the product and help determine the volumes needed to select glass molding over conventional single-point diamond turning or grinding and polishing. This brief report highlights key areas of both technologies with recommendations for further study.

  1. Extending the process limits of laser polymer welding with high-brilliance beam sources (recent status and prospects of POLYBRIGHT)

    Science.gov (United States)

    Olowinsky, A.; Boglea, A.

    2011-03-01

    Plastics play an important role in almost every facet of our lives and constitute a wide variety of products, from everyday products such as food and beverage packaging, over furniture and building materials to high tech products in the automotive, electronics, aerospace, white goods, medical and other sectors [1]. The objective of PolyBright, the European Research project on laser polymer welding, is to provide high speed and flexible laser manufacturing technology and expand the limits of current plastic part assembly. New laser polymer joining processes for optimized thermal management in combination with adapted wavelengths will provide higher quality, high processing speed up to 1 m/s and robust manufacturing processes at lower costs. Key innovations of the PolyBright project are fibre lasers with high powers up to 500 W, high speed scanning and flexible beam manipulation systems for simultaneous welding and high-resolution welding, such as dynamic masks and multi kHz scanning heads. With this initial step, PolyBright will break new paths in processing of advanced plastic products overcoming the quality and speed limitations of conventional plastic part assembly. Completely new concepts for high speed processing, flexibility and quality need to be established in combination with high brilliance lasers and related equipment. PolyBright will thus open new markets for laser systems with a short term potential of over several 100 laser installations per year and a future much larger market share in the still growing plastic market. PolyBright will hence establish a comprehensive and sustainable development activity on new high brilliance lasers that will strengthen the laser system industry.

  2. Cost-effectiveness of internal limiting membrane peeling versus no peeling for patients with an idiopathic full-thickness macular hole: results from a randomised controlled trial.

    Science.gov (United States)

    Ternent, Laura; Vale, Luke; Boachie, Charles; Burr, Jennifer M; Lois, Noemi

    2012-03-01

    To determine whether internal limiting membrane (ILM) peeling is cost-effective compared with no peeling for patients with an idiopathic stage 2 or 3 full-thickness macular hole. A cost-effectiveness analysis was performed alongside a randomised controlled trial. 141 participants were randomly allocated to receive macular-hole surgery, with either ILM peeling or no peeling. Health-service resource use, costs and quality of life were calculated for each participant. The incremental cost per quality-adjusted life year (QALY) gained was calculated at 6 months. At 6 months, the total costs were on average higher (£424, 95% CI -182 to 1045) in the No Peel arm, primarily owing to the higher reoperation rate in the No Peel arm. The mean additional QALYs from ILM peel at 6 months were 0.002 (95% CI 0.01 to 0.013), adjusting for baseline EQ-5D and other minimisation factors. A mean incremental cost per QALY was not computed, as Peeling was on average less costly and slightly more effective. A stochastic analysis suggested that there was more than a 90% probability that Peeling would be cost-effective at a willingness-to-pay threshold of £20,000 per QALY. Although there is no evidence of a statistically significant difference in either costs or QALYs between macular hole surgery with or without ILM peeling, the balance of probabilities is that ILM Peeling is likely to be a cost-effective option for the treatment of macular holes. Further long-term follow-up data are needed to confirm these findings.

  3. Synergistic methods for the production of high-strength and low-cost boron carbide

    Science.gov (United States)

    Wiley, Charles Schenck

    2011-12-01

    Boron carbide (B4C) is a non-oxide ceramic in the same class of nonmetallic hard materials as silicon carbide and diamond. The high hardness, high elastic modulus and low density of B4C make it a nearly ideal material for personnel and vehicular armor. B4C plates formed via hot-pressing are currently issued to U.S. soldiers and have exhibited excellent performance; however, hot-pressed articles contain inherent processing defects and are limited to simple geometries such as low-curvature plates. Recent advances in the pressureless sintering of B4C have produced theoretically-dense and complex-shape articles that also exhibit superior ballistic performance. However, the cost of this material is currently high due to the powder shape, size, and size distribution that are required, which limits the economic feasibility of producing such a product. Additionally, the low fracture toughness of pure boron carbide may have resulted in historically lower transition velocities (the projectile velocity range at which armor begins to fail) than competing silicon carbide ceramics in high-velocity long-rod tungsten penetrator tests. Lower fracture toughness also limits multi-hit protection capability. Consequently, these requirements motivated research into methods for improving the densification and fracture toughness of inexpensive boron carbide composites that could result in the development of a superior armor material that would also be cost-competitive with other high-performance ceramics. The primary objective of this research was to study the effect of titanium and carbon additives on the sintering and mechanical properties of inexpensive B4C powders. The boron carbide powder examined in this study was a sub-micron (0.6 mum median particle size) boron carbide powder produced by H.C. Starck GmbH via a jet milling process. A carbon source in the form of phenolic resin, and titanium additives in the form of 32 nm and 0.9 mum TiO2 powders were selected. Parametric studies of

  4. Automated packaging platform for low-cost high-performance optical components manufacturing

    Science.gov (United States)

    Ku, Robert T.

    2004-05-01

    Delivering high performance integrated optical components at low cost is critical to the continuing recovery and growth of the optical communications industry. In today's market, network equipment vendors need to provide their customers with new solutions that reduce operating expenses and enable new revenue generating IP services. They must depend on the availability of highly integrated optical modules exhibiting high performance, small package size, low power consumption, and most importantly, low cost. The cost of typical optical system hardware is dominated by linecards that are in turn cost-dominated by transmitters and receivers or transceivers and transponders. Cost effective packaging of optical components in these small size modules is becoming the biggest challenge to be addressed. For many traditional component suppliers in our industry, the combination of small size, high performance, and low cost appears to be in conflict and not feasible with conventional product design concepts and labor intensive manual assembly and test. With the advent of photonic integration, there are a variety of materials, optics, substrates, active/passive devices, and mechanical/RF piece parts to manage in manufacturing to achieve high performance at low cost. The use of automation has been demonstrated to surpass manual operation in cost (even with very low labor cost) as well as product uniformity and quality. In this paper, we will discuss the value of using an automated packaging platform.for the assembly and test of high performance active components, such as 2.5Gb/s and 10 Gb/s sources and receivers. Low cost, high performance manufacturing can best be achieved by leveraging a flexible packaging platform to address a multitude of laser and detector devices, integration of electronics and handle various package bodies and fiber configurations. This paper describes the operation and results of working robotic assemblers in the manufacture of a Laser Optical Subassembly

  5. Scalable Light Module for Low-Cost, High-Efficiency Light- Emitting Diode Luminaires

    Energy Technology Data Exchange (ETDEWEB)

    Tarsa, Eric [Cree, Inc., Goleta, CA (United States)

    2015-08-31

    During this two-year program Cree developed a scalable, modular optical architecture for low-cost, high-efficacy light emitting diode (LED) luminaires. Stated simply, the goal of this architecture was to efficiently and cost-effectively convey light from LEDs (point sources) to broad luminaire surfaces (area sources). By simultaneously developing warm-white LED components and low-cost, scalable optical elements, a high system optical efficiency resulted. To meet program goals, Cree evaluated novel approaches to improve LED component efficacy at high color quality while not sacrificing LED optical efficiency relative to conventional packages. Meanwhile, efficiently coupling light from LEDs into modular optical elements, followed by optimally distributing and extracting this light, were challenges that were addressed via novel optical design coupled with frequent experimental evaluations. Minimizing luminaire bill of materials and assembly costs were two guiding principles for all design work, in the effort to achieve luminaires with significantly lower normalized cost ($/klm) than existing LED fixtures. Chief project accomplishments included the achievement of >150 lm/W warm-white LEDs having primary optics compatible with low-cost modular optical elements. In addition, a prototype Light Module optical efficiency of over 90% was measured, demonstrating the potential of this scalable architecture for ultra-high-efficacy LED luminaires. Since the project ended, Cree has continued to evaluate optical element fabrication and assembly methods in an effort to rapidly transfer this scalable, cost-effective technology to Cree production development groups. The Light Module concept is likely to make a strong contribution to the development of new cost-effective, high-efficacy luminaries, thereby accelerating widespread adoption of energy-saving SSL in the U.S.

  6. Study on the fuel cycle cost of gas turbine high temperature reactor (GTHTR300). Contract research

    Energy Technology Data Exchange (ETDEWEB)

    Takei, Masanobu; Katanishi, Shoji; Nakata, Tetsuo; Kunitomi, Kazuhiko [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Oda, Takefumi; Izumiya, Toru [Nuclear Fuel Industries, Ltd., Tokyo (Japan)

    2002-11-01

    In the basic design of gas turbine high temperature reactor (GTHTR300), reduction of the fuel cycle cost has a large benefit of improving overall plant economy. Then, fuel cycle cost was evaluated for GTHTR300. First, of fuel fabrication for high-temperature gas cooled reactor, since there was no actual experience with a commercial scale, a preliminary design for a fuel fabrication plant with annual processing of 7.7 ton-U sufficient four GTHTR300 was performed, and fuel fabrication cost was evaluated. Second, fuel cycle cost was evaluated based on the equilibrium cycle of GTHTR300. The factors which were considered in this cost evaluation include uranium price, conversion, enrichment, fabrication, storage of spent fuel, reprocessing, and waste disposal. The fuel cycle cost of GTHTR300 was estimated at about 1.07 yen/kWh. If the back-end cost of reprocessing and waste disposal is included and assumed to be nearly equivalent to LWR, the fuel cycle cost of GTHTR300 was estimated to be about 1.31 yen/kWh. Furthermore, the effects on fuel fabrication cost by such of fuel specification parameters as enrichment, the number of fuel types, and the layer thickness were considered. Even if the enrichment varies from 10 to 20%, the number of fuel types change from 1 to 4, the 1st layer thickness of fuel changes by 30 {mu}m, or the 2nd layer to the 4th layer thickness of fuel changes by 10 {mu}m, the impact on fuel fabrication cost was evaluated to be negligible. (author)

  7. Investigation of different modifications of the modular high temperature reactor for cost reduction

    International Nuclear Information System (INIS)

    Heek, A. van.

    1993-06-01

    Regarding the specific costs reactor with low power output have disadvantages compared to large reactors. In this study it was investigated for the HTR Module how to reduce the specific investment costs and consequently the electricity production costs by modification of the reactor and the power plant design. To reduce the investment costs different design changes were investigated, e.g. possible alternatives for the arrangement of the reactors and the steam generators and a different building layout. The cost reduction gained by a more compact type of construction and a reduction of the number of large components remains below 10%. The use of a gas turbine instead of a steam turbine with steam generator would result in a more efficient cost reduction. The increase in the power output has a much bigger potential to reduce the electricity production costs. The best way to realize this is the changing of the core geometry from cylindric to annular. A module concept with a power maximized under certain boundary conditions (limitation of the core temperatures in case of accident, use of proven technology) was worked out in detail. The optimum core geometry and power density, determined by tolerable accident temperatures and core pressure loss, make a thermal power of 350 MW possible. The physical properties and the accident behaviour in case of pressure release and water ingress were investigated. The specific investment costs and the electricity production costs of a 4-Modular Plant for pure electricity production are reduced about 28% resp. 19% compared with the 200 MWth-Module (KWU/Interatom). (orig.) [de

  8. Development of low-cost high-performance multispectral camera system at Banpil

    Science.gov (United States)

    Oduor, Patrick; Mizuno, Genki; Olah, Robert; Dutta, Achyut K.

    2014-05-01

    Banpil Photonics (Banpil) has developed a low-cost high-performance multispectral camera system for Visible to Short- Wave Infrared (VIS-SWIR) imaging for the most demanding high-sensitivity and high-speed military, commercial and industrial applications. The 640x512 pixel InGaAs uncooled camera system is designed to provide a compact, smallform factor to within a cubic inch, high sensitivity needing less than 100 electrons, high dynamic range exceeding 190 dB, high-frame rates greater than 1000 frames per second (FPS) at full resolution, and low power consumption below 1W. This is practically all the feature benefits highly desirable in military imaging applications to expand deployment to every warfighter, while also maintaining a low-cost structure demanded for scaling into commercial markets. This paper describes Banpil's development of the camera system including the features of the image sensor with an innovation integrating advanced digital electronics functionality, which has made the confluence of high-performance capabilities on the same imaging platform practical at low cost. It discusses the strategies employed including innovations of the key components (e.g. focal plane array (FPA) and Read-Out Integrated Circuitry (ROIC)) within our control while maintaining a fabless model, and strategic collaboration with partners to attain additional cost reductions on optics, electronics, and packaging. We highlight the challenges and potential opportunities for further cost reductions to achieve a goal of a sub-$1000 uncooled high-performance camera system. Finally, a brief overview of emerging military, commercial and industrial applications that will benefit from this high performance imaging system and their forecast cost structure is presented.

  9. Low Cost Automated Manufacture of High Efficiency THINS ZTJ PV Blanket Technology (P-NASA12-007), Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA needs lower cost solar arrays with high performance for a variety of missions. While high efficiency, space-qualified solar cells are in themselves costly, >...

  10. Bevacizumab in Treatment of High-Risk Ovarian Cancer—A Cost-Effectiveness Analysis

    Science.gov (United States)

    Herzog, Thomas J.; Hu, Lilian; Monk, Bradley J.; Kiet, Tuyen; Blansit, Kevin; Kapp, Daniel S.; Yu, Xinhua

    2014-01-01

    Objective. The objective of this study was to evaluate a cost-effectiveness strategy of bevacizumab in a subset of high-risk advanced ovarian cancer patients with survival benefit. Methods. A subset analysis of the International Collaboration on Ovarian Neoplasms 7 trial showed that additions of bevacizumab (B) and maintenance bevacizumab (mB) to paclitaxel (P) and carboplatin (C) improved the overall survival (OS) of high-risk advanced cancer patients. Actual and estimated costs of treatment were determined from Medicare payment. Incremental cost-effectiveness ratio per life-year saved was established. Results. The estimated cost of PC is $535 per cycle; PCB + mB (7.5 mg/kg) is $3,760 per cycle for the first 6 cycles and then $3,225 per cycle for 12 mB cycles. Of 465 high-risk stage IIIC (>1 cm residual) or stage IV patients, the previously reported OS after PC was 28.8 months versus 36.6 months in those who underwent PCB + mB. With an estimated 8-month improvement in OS, the incremental cost-effectiveness ratio of B was $167,771 per life-year saved. Conclusion. In this clinically relevant subset of women with high-risk advanced ovarian cancer with overall survival benefit after bevacizumab, our economic model suggests that the incremental cost of bevacizumab was approximately $170,000. PMID:24721817

  11. The role of mental health and addiction among high-cost patients: a population-based study.

    Science.gov (United States)

    de Oliveira, Claire; Cheng, Joyce; Rehm, Jürgen; Kurdyak, Paul

    2018-04-01

    Previous work found that, among high-cost patients, those with a majority of mental health and addiction (MHA)-related costs (>50%) incur over 30% more costs than other high-cost patients. However, this work did not examine other high-cost patients in depth or whether they had any MHA-related costs. The objective of this analysis was to examine the role of MHA-related care among other high-cost patients. Using administrative healthcare data from Ontario, Canada, this study selected all patients in the 90th percentile of the cost distribution in 2012. It focused primarily on two groups based on the percentage of MHA-related costs relative to total costs: (1) high-cost patients with some MHA-related costs (0% > and cost patients with no MHA-related costs (0%). We examined socio-demographic and clinical characteristics, utilization and costs for both groups, and modeled patient-level costs using appropriate regression techniques. We also compared these groups with high-cost patients with a majority of MHA-related costs (>50%). High-cost patients with some MHA-related costs incurred over 40% more costs than those without ($27,883 vs $19,702). Patients with some MHA-related costs were older, lived in poorer neighborhoods, and had higher levels of comorbidity compared to those without. After controlling for relevant variables, having any type of MHA-related utilization increased costs by $2,698. Having a diagnosis of psychosis had a large impact on costs. This study did not examine children and adolescents. We were only able to account for 91% of all costs incurred by the public third-party payer; addiction-related costs from community-based agencies were not available. High-cost patients with MHA incur higher costs compared to those without. When considering interventions aimed at high-cost patients, policy-makers should consider their complex nature, specifically both their physical and MHA-related comorbidities.

  12. High frequency components of tracheal sound are emphasized during prolonged flow limitation

    International Nuclear Information System (INIS)

    Tenhunen, M; Huupponen, E; Saastamoinen, A; Kulkas, A; Himanen, S-L; Rauhala, E

    2009-01-01

    A nasal pressure transducer, which is used to study nocturnal airflow, also provides information about the inspiratory flow waveform. A round flow shape is presented during normal breathing. A flattened, non-round shape is found during hypopneas and it can also appear in prolonged episodes. The significance of this prolonged flow limitation is still not established. A tracheal sound spectrum has been analyzed further in order to achieve additional information about breathing during sleep. Increased sound frequencies over 500 Hz have been connected to obstruction of the upper airway. The aim of the present study was to examine the tracheal sound signal content of prolonged flow limitation and to find out whether prolonged flow limitation would consist of abundant high frequency activity. Sleep recordings of 36 consecutive patients were examined. The tracheal sound spectral analysis was performed on 10 min episodes of prolonged flow limitation, normal breathing and periodic apnea-hypopnea breathing. The highest total spectral amplitude, implicating loudest sounds, occurred during flow-limited breathing which also presented loudest sounds in all frequency bands above 100 Hz. In addition, the tracheal sound signal during flow-limited breathing constituted proportionally more high frequency activities compared to normal breathing and even periodic apnea-hypopnea breathing

  13. Cross-Continuum Tool Is Associated with Reduced Utilization and Cost for Frequent High-Need Users.

    Science.gov (United States)

    Hardin, Lauran; Kilian, Adam; Muller, Leslie; Callison, Kevin; Olgren, Michael

    2017-02-01

    High-need, high-cost (HNHC) patients can over-use acute care services, a pattern of behavior associated with many poor outcomes that disproportionately contributes to increased U.S. healthcare cost. Our objective was to reduce healthcare cost and improve outcomes by optimizing the system of care. We targeted HNHC patients and identified root causes of frequent healthcare utilization. We developed a cross-continuum intervention process and a succinct tool called a Complex Care Map (CCM)© that addresses fragmentation in the system and links providers to a comprehensive individualized analysis of the patient story and causes for frequent access to health services. Using a pre-/post-test design in which each subject served as his/her own historical control, this quality improvement project focused on determining if the interdisciplinary intervention called CCM© had an impact on healthcare utilization and costs for HNHC patients. We conducted the analysis between November 2012 and December 2015 at Mercy Health Saint Mary's, a Midwestern urban hospital with greater than 80,000 annual emergency department (ED) visits. All referred patients with three or more hospital visits (ED or inpatient [IP]) in the 12 months prior to initiation of a CCM© (n=339) were included in the study. Individualized CCMs© were created and made available in the electronic medical record (EMR) to all healthcare providers. We compared utilization, cost, social, and healthcare access variables from the EMR and cost-accounting system for 12 months before and after CCMs© implementation. We used both descriptive and limited inferential statistics. ED mean visits decreased 43% (pcost of care.

  14. Reduction of electricity comsumption during 'high cost' periods in winter 2005 - 2006

    CERN Multimedia

    Mario Batz

    2005-01-01

    In previous years CERN was able to limit its electricity consumption during the winter months sufficiently to be supplied from the Swiss grid. In order to make enough power available for the LHC machine and experiments at the lowest possible cost during the coming winter 2005 / 2006 CERN is supplied from the French grid by EDF (Electricité de France). As a consequence, when the grids are at peak demand during the tariff period 'Effacement Jour de Pointe' (EJP) in France, the energy price is at least four times as high as for the usual winter period. From 1st November until 31st March these increased prices are applicable during twenty-two 18-hour periods, each beginning at 7 a.m. and ending at 1 a.m. the following day. Notice will be given by EDF to the Technical Infrastructure Control Room (TI) at 5 p.m. the previous day. The notice period may be reduced to two hours for days following weekends and public holidays, or omitted entirely for technical reasons. During these days of EJP CERN has a strong fina...

  15. A highly sensitive, low-cost, wearable pressure sensor based on conductive hydrogel spheres

    KAUST Repository

    Tai, Yanlong

    2015-01-01

    Wearable pressure sensing solutions have promising future for practical applications in health monitoring and human/machine interfaces. Here, a highly sensitive, low-cost, wearable pressure sensor based on conductive single-walled carbon nanotube (SWCNT)/alginate hydrogel spheres is reported. Conductive and piezoresistive spheres are embedded between conductive electrodes (indium tin oxide-coated polyethylene terephthalate films) and subjected to environmental pressure. The detection mechanism is based on the piezoresistivity of the SWCNT/alginate conductive spheres and on the sphere-electrode contact. Step-by-step, we optimized the design parameters to maximize the sensitivity of the sensor. The optimized hydrogel sensor exhibited a satisfactory sensitivity (0.176 ΔR/R0/kPa-1) and a low detectable limit (10 Pa). Moreover, a brief response time (a few milliseconds) and successful repeatability were also demonstrated. Finally, the efficiency of this strategy was verified through a series of practical tests such as monitoring human wrist pulse, detecting throat muscle motion or identifying the location and the distribution of an external pressure using an array sensor (4 × 4). © 2015 The Royal Society of Chemistry.

  16. [Access to high-cost drugs in Brazil from the perspective of physicians, pharmacists and patients].

    Science.gov (United States)

    Rover, Marina Raijche Mattozo; Vargas-Pelaez, Claudia Marcela; Rocha Farias, Mareni; Nair Leite, Silvana

    2016-01-01

    To explore perceptions on access to medication supplied by the Specialized Component of Pharmaceutical Assistance (CEAF) within the Brazilian Unified Health System (which includes high-cost drugs) by the actors involved in the healthcare services of this component. A descriptive, qualitative study was carried out by using a focal group with 7 users and 11 semi-structured interviews with health professionals (physicians and pharmacist) in the state of Santa Catarina. According to the participants, access to medicines had improved. Two main perceptions of the CEAF Clinical Guidelines were identified: the requirements constitute a bureaucracy that limits access, and the requisites increase the demand for tests and specialized healthcare services, exceeding the capacity of the healthcare services network. These assumptions generated the search for other means of access that revealed a lack of information and understanding of the right to health among the users. In addition, according to the participants, because of the difficulties of accessing services as a whole, full access to CEAF medicines is a goal that remains to be achieved. Although access to CEAF medicines has improved, there are still some difficulties in guaranteeing treatment access and comprehensiveness. Copyright © 2016 SESPAS. Published by Elsevier Espana. All rights reserved.

  17. Source limitation of carbon gas emissions in high-elevation mountain streams and lakes

    Science.gov (United States)

    Crawford, John T.; Dornblaser, Mark M.; Stanley, Emily H.; Clow, David W.; Striegl, Robert G.

    2015-01-01

    Inland waters are an important component of the global carbon cycle through transport, storage, and direct emissions of CO2 and CH4 to the atmosphere. Despite predictions of high physical gas exchange rates due to turbulent flows and ubiquitous supersaturation of CO2—and perhaps also CH4—patterns of gas emissions are essentially undocumented for high mountain ecosystems. Much like other headwater networks around the globe, we found that high-elevation streams in Rocky Mountain National Park, USA, were supersaturated with CO2 during the growing season and were net sources to the atmosphere. CO2concentrations in lakes, on the other hand, tended to be less than atmospheric equilibrium during the open water season. CO2 and CH4 emissions from the aquatic conduit were relatively small compared to many parts of the globe. Irrespective of the physical template for high gas exchange (high k), we found evidence of CO2 source limitation to mountain streams during the growing season, which limits overall CO2emissions. Our results suggest a reduced importance of aquatic ecosystems for carbon cycling in high-elevation landscapes having limited soil development and high CO2 consumption via mineral weathering.

  18. Case Managers for High-Risk, High-Cost Patients as Agents and Street-Level Bureaucrats.

    Science.gov (United States)

    Swanson, Jeffrey; Weissert, William G

    2017-08-01

    Case management programs often designate a nurse or social worker to take responsibility for guiding care when patients are expected to be expensive or risk a major decline. We hypothesized that though an intuitively appealing idea, careful program design and faithful implementation are essential if case management programs are to succeed. We employed two theory perspectives, principal-agent framework and street-level bureaucratic theory to describe the relationship between program designers (principals) and case managers (agents/street-level bureaucrats) to review 65 case management studies. Most programs were successful in limited program-specific process and outcome goals. But there was much less success in cost-saving or cost-effectiveness-the original and overarching goal of case management. Cost results might be improved if additional ideas of agency and street-level theory were adopted, specifically, incentives, as well as "green tape," clear rules, guidelines, and algorithms relating to resource allocation among patients.

  19. Effect of RF Parameters on Breakdown Limits in High-Vacuum X-Band Structures

    International Nuclear Information System (INIS)

    Dolgashev, Valery A.

    2003-01-01

    RF breakdown is one of the major factors determining performance of high power rf components and rf sources. RF breakdown limits working power and produces irreversible surface damage. The breakdown limit depends on the rf circuit, structure geometry, and rf frequency. It is also a function of the input power, pulse width, and surface electric and magnetic fields. In this paper we discuss multi-megawatt operation of X-band rf structures at pulse width on the order of one microsecond. These structures are used in rf systems of high gradient accelerators. Recent experiments at Stanford Linear Accelerator Center (SLAC) have explored the functional dependence of breakdown limit on input power and pulse width. The experimental data covered accelerating structures and waveguides. Another breakdown limit of accelerating structures was associated with high magnetic fields found in waveguide-to-structure couplers. To understand and quantify these limits we simulated 3D structures with the electrodynamics code Ansoft HFSS and the Particle-In-Cell code MAGIC3D. Results of these simulations together with experimental data will be discussed in this paper

  20. Effects of Limited Hydrolysis and High-Pressure Homogenization on Functional Properties of Oyster Protein Isolates.

    Science.gov (United States)

    Yu, Cuiping; Cha, Yue; Wu, Fan; Xu, Xianbing; Du, Ming

    2018-03-22

    In this study, the effects of limited hydrolysis and/or high-pressure homogenization (HPH) treatment in acid conditions on the functional properties of oyster protein isolates (OPI) were studied. Protein solubility, surface hydrophobicity, particle size distribution, zeta potential, foaming, and emulsifying properties were evaluated. The results showed that acid treatment led to the dissociation and unfolding of OPI. Subsequent treatment such as limited proteolysis, HPH, and their combination remarkably improved the functional properties of OPI. Acid treatment produced flexible aggregates, as well as reduced particle size and solubility. On the contrary, limited hydrolysis increased the solubility of OPI. Furthermore, HPH enhanced the effectiveness of the above treatments. The emulsifying and foaming properties of acid- or hydrolysis-treated OPI significantly improved. In conclusion, a combination of acid treatment, limited proteolysis, and HPH improved the functional properties of OPI. The improvements in the functional properties of OPI could potentiate the use of oyster protein and its hydrolysates in the food industry.

  1. Scaling Limit of Symmetric Random Walk in High-Contrast Periodic Environment

    Science.gov (United States)

    Piatnitski, A.; Zhizhina, E.

    2017-11-01

    The paper deals with the asymptotic properties of a symmetric random walk in a high contrast periodic medium in Z^d, d≥1. From the existing homogenization results it follows that under diffusive scaling the limit behaviour of this random walk need not be Markovian. The goal of this work is to show that if in addition to the coordinate of the random walk in Z^d we introduce an extra variable that characterizes the position of the random walk inside the period then the limit dynamics of this two-component process is Markov. We describe the limit process and observe that the components of the limit process are coupled. We also prove the convergence in the path space for the said random walk.

  2. Low-cost high-quality crystalline germanium based flexible devices

    KAUST Repository

    Nassar, Joanna M.

    2014-06-16

    High performance flexible electronics promise innovative future technology for various interactive applications for the pursuit of low-cost, light-weight, and multi-functional devices. Thus, here we show a complementary metal oxide semiconductor (CMOS) compatible fabrication of flexible metal-oxide-semiconductor capacitors (MOSCAPs) with high-κ/metal gate stack, using a physical vapor deposition (PVD) cost-effective technique to obtain a high-quality Ge channel. We report outstanding bending radius ~1.25 mm and semi-transparency of 30%.

  3. Low-cost high-quality crystalline germanium based flexible devices

    KAUST Repository

    Nassar, Joanna M.; Hussain, Aftab M.; Rojas, Jhonathan Prieto; Hussain, Muhammad Mustafa

    2014-01-01

    High performance flexible electronics promise innovative future technology for various interactive applications for the pursuit of low-cost, light-weight, and multi-functional devices. Thus, here we show a complementary metal oxide semiconductor (CMOS) compatible fabrication of flexible metal-oxide-semiconductor capacitors (MOSCAPs) with high-κ/metal gate stack, using a physical vapor deposition (PVD) cost-effective technique to obtain a high-quality Ge channel. We report outstanding bending radius ~1.25 mm and semi-transparency of 30%.

  4. A high volume cost efficient production macrostructuring process. [for silicon solar cell surface treatment

    Science.gov (United States)

    Chitre, S. R.

    1978-01-01

    The paper presents an experimentally developed surface macro-structuring process suitable for high volume production of silicon solar cells. The process lends itself easily to automation for high throughput to meet low-cost solar array goals. The tetrahedron structure observed is 0.5 - 12 micron high. The surface has minimal pitting with virtually no or very few undeveloped areas across the surface. This process has been developed for (100) oriented as cut silicon. Chemi-etched, hydrophobic and lapped surfaces were successfully texturized. A cost analysis as per Samics is presented.

  5. The high intensity solar cell: Key to low cost photovoltaic power

    Science.gov (United States)

    Sater, B. L.; Goradia, C.

    1975-01-01

    The design considerations and performance characteristics of the 'high intensity' (HI) solar cell are presented. A high intensity solar system was analyzed to determine its cost effectiveness and to assess the benefits of further improving HI cell efficiency. It is shown that residential sized systems can be produced at less than $1000/kW peak electric power. Due to their superior high intensity performance characteristics compared to the conventional and VMJ cells, HI cells and light concentrators may be the key to low cost photovoltaic power.

  6. Potential Impact of a Free Online HIV Treatment Response Prediction System for Reducing Virological Failures and Drug Costs after Antiretroviral Therapy Failure in a Resource-Limited Setting

    Directory of Open Access Journals (Sweden)

    Andrew D. Revell

    2013-01-01

    Full Text Available Objective. Antiretroviral drug selection in resource-limited settings is often dictated by strict protocols as part of a public health strategy. The objective of this retrospective study was to examine if the HIV-TRePS online treatment prediction tool could help reduce treatment failure and drug costs in such settings. Methods. The HIV-TRePS computational models were used to predict the probability of response to therapy for 206 cases of treatment change following failure in India. The models were used to identify alternative locally available 3-drug regimens, which were predicted to be effective. The costs of these regimens were compared to those actually used in the clinic. Results. The models predicted the responses to treatment of the cases with an accuracy of 0.64. The models identified alternative drug regimens that were predicted to result in improved virological response and lower costs than those used in the clinic in 85% of the cases. The average annual cost saving was $364 USD per year (41%. Conclusions. Computational models that do not require a genotype can predict and potentially avoid treatment failure and may reduce therapy costs. The use of such a system to guide therapeutic decision-making could confer health economic benefits in resource-limited settings.

  7. Limited Angle Torque Motors Having High Torque Density, Used in Accurate Drive Systems

    Directory of Open Access Journals (Sweden)

    R. Obreja

    2011-01-01

    Full Text Available A torque motor is a special electric motor that is able to develop the highest possible torque in a certain volume. A torque motor usually has a pancake configuration, and is directly jointed to a drive system (without a gear box. A limited angle torque motor is a torque motor that has no rotary electromagnetic field — in certain papers it is referred to as a linear electromagnet. The main intention of the authors for this paper is to present a means for analyzing and designing a limited angle torque motor only through the finite element method. Users nowadays require very high-performance limited angle torque motors with high density torque. It is therefore necessary to develop the highest possible torque in a relatively small volume. A way to design such motors is by using numerical methods based on the finite element method.

  8. Impurity screening in high density plasmas in tokamaks with a limiter configuration

    International Nuclear Information System (INIS)

    Ferro, C.; Zanino, R.

    1992-01-01

    Impurity screening in high density plasmas in tokamaks with a limiter configuration is investigated by means of a simple semi-analytical model. An iterative scheme is devised, in order to determine self-consistently the values of scrape-off layer thickness, edge electron density and temperature, and main plasma contamination parameter Z eff , as a function of given average electron density and temperature in the main plasma and given input power. The model is applied to the poloidal limiter case of the Frascati Tokamak Upgrade, and results are compared with experimental data. A reasonable agreement between the trends is found, emphasizing the importance of a high edge plasma density for obtaining a clean main plasma in limiter tokamaks. (orig.)

  9. Second Generation Novel High Temperature Commercial Receiver & Low Cost High Performance Mirror Collector for Parabolic Solar Trough

    Energy Technology Data Exchange (ETDEWEB)

    Stettenheim, Joel [Norwich Technologies, White River Junction, VT (United States)

    2016-02-29

    Norwich Technologies (NT) is developing a disruptively superior solar field for trough concentrating solar power (CSP). Troughs are the leading CSP technology (85% of installed capacity), being highly deployable and similar to photovoltaic (PV) systems for siting. NT has developed the SunTrap receiver, a disruptive alternative to vacuum-tube concentrating solar power (CSP) receivers, a market currently dominated by the Schott PTR-70. The SunTrap receiver will (1) operate at higher temperature (T) by using an insulated, recessed radiation-collection system to overcome the energy losses that plague vacuum-tube receivers at high T, (2) decrease acquisition costs via simpler structure, and (3) dramatically increase reliability by eliminating vacuum. It offers comparable optical efficiency with thermal loss reduction from ≥ 26% (at presently standard T) to ≥ 55% (at high T), lower acquisition costs, and near-zero O&M costs.

  10. Cost calculation and financial measures for high-level waste disposal business

    International Nuclear Information System (INIS)

    Sekiguchi, Hiromasa.

    1987-01-01

    A study is made on the costs for disposal of high-level wastes, centering on financial problems involving cost calculation for disposal business and methods and systems for funding the business. The first half of the report is focused on calculation of costs for disposal business. Basic equations are shown to calculate the total costs required for a disposal plant and the costs for disposal of one unit of high-level wastes. A model is proposed to calculate the charges to be paid by electric power companies to the plant for disposal of their wastes. Another equation is derived to calculate the disposal charge per kWh of power generation in a power plant. The second half of the report is focused on financial measures concerning expenses for disposal. A financial basis should be established for the implementation of high-level waste disposal. It is insisted that a reasonable method for estimating the disposal costs should be set up and it should be decided who will pay the expenses. Discussions are made on some methods and systems for funding the disposal business. An additional charge should be included in the electricity bill to be paid by electric power users, or it should be included in tax. (Nogami, K.)

  11. Exploring the Limits of Crop Productivity: High Light Studies with Lettuce

    OpenAIRE

    USU Crop Physiology Lab

    2015-01-01

    There are many different leaf lettuce cultivars and they range in color from light green and yellow to deep green as a result of higher concentrations of chlorophyll in the leaves. We tested four cultivars in high light to explore the limits of lettuce productivity.

  12. Double-Higgs boson production in the high-energy limit: planar master integrals

    Science.gov (United States)

    Davies, Joshua; Mishima, Go; Steinhauser, Matthias; Wellmann, David

    2018-03-01

    We consider the virtual corrections to the process gg → HH at NLO in the high energy limit and compute the corresponding planar master integrals in an expansion for small top quark mass. We provide details on the evaluation of the boundary conditions and present analytic results expressed in terms of harmonic polylogarithms.

  13. Starch hydrolysis in autogenerative high pressure digestion: Gelatinisation and saccharification as rate limiting steps

    NARCIS (Netherlands)

    Lindeboom, R.E.F.; Ding, L.; Weijma, J.; Plugge, C.M.; Lier, van J.B.

    2014-01-01

    Autogenerative high pressure digestion (AHPD) provides an integrated biogas upgrading technology, capable of producing biogas with a CH4 content exceeding 95% at pressures up to 90 bar. Hydrolysis is generally regarded as the rate-limiting step in the anaerobic digestion of complex organic matter,

  14. Pre-fracture individual characteristics associated with high total health care costs after hip fracture.

    Science.gov (United States)

    Schousboe, J T; Paudel, M L; Taylor, B C; Kats, A M; Virnig, B A; Dowd, B E; Langsetmo, L; Ensrud, K E

    2017-03-01

    Older women with pre-fracture slow walk speed, high body mass index, and/or a high level of multimorbidity have significantly higher health care costs after hip fracture compared to those without those characteristics. Studies to investigate if targeted health care interventions for these individuals can reduce hip fracture costs are warranted. The aim of this study is to estimate the associations of individual pre-fracture characteristics with total health care costs after hip fracture, using Study of Osteoporotic Fractures (SOF) cohort data linked to Medicare claims. Our study population was 738 women age 70 and older enrolled in Medicare Fee for Service (FFS) who experienced an incident hip fracture between January 1, 1992 and December 31, 2009. We assessed pre-fracture individual characteristics at SOF study visits and estimated costs of hospitalizations, skilled nursing facility and inpatient rehabilitation stays, home health care visits, and outpatient utilization from Medicare FFS claims. We used generalized linear models to estimate the associations of predictor variables with total health care costs (2010 US dollars) after hip fracture. Median total health care costs for 1 year after hip fracture were $35,536 (inter-quartile range $24,830 to $50,903). Multivariable-adjusted total health care costs for 1 year after hip fracture were 14 % higher ($5256, 95 % CI $156 to $10,356) in those with walk speed total health care costs after hip fracture in older women. Studies to investigate if targeted health care interventions for these individuals can reduce the costs of hip fractures are warranted.

  15. Cost-effectiveness of annual versus biennial screening mammography for women with high mammographic breast density.

    Science.gov (United States)

    Pataky, Reka; Ismail, Zahra; Coldman, Andrew J; Elwood, Mark; Gelmon, Karen; Hedden, Lindsay; Hislop, Greg; Kan, Lisa; McCoy, Bonnie; Olivotto, Ivo A; Peacock, Stuart

    2014-12-01

    The sensitivity of screening mammography is much lower among women who have dense breast tissue, compared with women who have largely fatty breasts, and they are also at much higher risk of developing the disease. Increasing mammography screening frequency from biennially to annually has been suggested as a policy option to address the elevated risk in this population. The purpose of this study was to assess the cost-effectiveness of annual versus biennial screening mammography among women aged 50-79 with dense breast tissue. A Markov model was constructed based on screening, diagnostic, and treatment pathways for the population-based screening and cancer care programme in British Columbia, Canada. Model probabilities and screening costs were calculated from screening programme data. Costs for breast cancer treatment were calculated from treatment data, and utility values were obtained from the literature. Incremental cost-effectiveness was expressed as cost per quality adjusted life year (QALY), and probabilistic sensitivity analysis was conducted. Compared with biennial screening, annual screening generated an additional 0.0014 QALYs (95% CI: -0.0480-0.0359) at a cost of $819 ($ = Canadian dollars) per patient (95% CI: 506-1185), resulting in an incremental cost effectiveness ratio of $565,912/QALY. Annual screening had a 37.5% probability of being cost-effective at a willingness-to-pay threshold of $100,000/QALY. There is considerable uncertainty about the incremental cost-effectiveness of annual mammography. Further research on the comparative effectiveness of screening strategies for women with high mammographic breast density is warranted, particularly as digital mammography and density measurement become more widespread, before cost-effectiveness can be reevaluated. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  16. High-cost users of hospital beds in Western Australia: a population-based record linkage study.

    Science.gov (United States)

    Calver, Janine; Brameld, Kate J; Preen, David B; Alexia, Stoney J; Boldy, Duncan P; McCaul, Kieran A

    2006-04-17

    To describe how high-cost users of inpatient care in Western Australia differ from other users in age, health problems and resource use. Secondary analysis of hospital data and linked mortality data from the WA Data Linkage System for 2002, with cost data from the National Hospital Cost Data Collection (2001-02 financial year). Comparison of high-cost users and other users of inpatient care in terms of age, health profile (major diagnostic category) and resource use (annualised costs, separations and bed days). Older high-cost users (> or = 65 years) were not more expensive to treat than younger high-cost users (at the patient level), but were costlier as a group overall because of their disproportionate representation (n = 8466; 55.9%). Chronic stable and unstable conditions were a key feature of high-cost users, and included end stage renal disease, angina, depression and secondary malignant neoplasms. High-cost users accounted for 38% of both inpatient costs and inpatient days, and 26% of inpatient separations. Ageing of the population is associated with an increase in the proportion of high-cost users of inpatient care. High costs appear to be needs-driven. Constraining high-cost inpatient use requires more focus on preventing the onset and progression of chronic disease, and reducing surgical complications and injuries in vulnerable groups.

  17. Low-Cost Bio-Based Carbon Fibers for High Temperature Processing

    Energy Technology Data Exchange (ETDEWEB)

    Paul, Ryan Michael [GrafTech International, Brooklyn Heights, OH (United States); Naskar, Amit [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-03

    GrafTech International Holdings Inc. (GTI), under Award No. DE-EE0005779, worked with Oak Ridge National Laboratory (ORNL) under CRADA No. NFE-15-05807 to develop lignin-based carbon fiber (LBCF) technology and to demonstrate LBCF performance in high-temperature products and applications. This work was unique and different from other reported LBCF work in that this study was application-focused and scalability-focused. Accordingly, the executed work was based on meeting criteria based on technology development, cost, and application suitability. High-temperature carbon fiber based insulation is used in energy intensive industries, such as metal heat treating and ceramic and semiconductor material production. Insulation plays a critical role in achieving high thermal and process efficiency, which is directly related to energy usage, cost, and product competitiveness. Current high temperature insulation is made with petroleum based carbon fibers, and one goal of this protect was to develop and demonstrate an alternative lignin (biomass) based carbon fiber that would achieve lower cost, CO2 emissions, and energy consumption and result in insulation that met or exceeded the thermal efficiency of current commercial insulation. In addition, other products were targeted to be evaluated with LBCF. As the project was designed to proceed in stages, the initial focus of this work was to demonstrate lab-scale LBCF from at least 4 different lignin precursor feedstock sources that could meet the estimated production cost of $5.00/pound and have ash level of less than 500 ppm in the carbonized insulation-grade fiber. Accordingly, a preliminary cost model was developed based on publicly available information. The team demonstrated that 4 lignin samples met the cost criteria. In addition, the ash level for the 4 carbonized lignin samples was below 500 ppm. Processing as-received lignin to produce a high purity lignin fiber was a significant accomplishment in that most industrial

  18. Low–Cost Bio-Based Carbon Fiber for High-Temperature Processing

    Energy Technology Data Exchange (ETDEWEB)

    Naskar, Amit K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Akato, Kokouvi M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Tran, Chau D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Paul, Ryan M. [GrafTech International Holdings, Inc., Brooklyn Heights, OH (United States); Dai, Xuliang [GrafTech International Holdings, Inc., Brooklyn Heights, OH (United States)

    2017-02-01

    GrafTech International Holdings Inc. (GTI), worked with Oak Ridge National Laboratory (ORNL) under CRADA No. NFE-15-05807 to develop lignin-based carbon fiber (LBCF) technology and to demonstrate LBCF performance in high-temperature products and applications. This work was unique and different from other reported LBCF work in that this study was application-focused and scalability-focused. Accordingly, the executed work was based on meeting criteria based on technology development, cost, and application suitability. The focus of this work was to demonstrate lab-scale LBCF from at least 4 different precursor feedstock sources that could meet the estimated production cost of $5.00/pound and have ash level of less than 500 ppm in the carbonized insulation-grade fiber. Accordingly, a preliminary cost model was developed based on publicly available information. The team demonstrated that 4 lignin samples met the cost criteria, as highlighted in Table 1. In addition, the ash level for the 4 carbonized lignin samples were below 500 ppm. Processing asreceived lignin to produce a high purity lignin fiber was a significant accomplishment in that most industrial lignin, prior to purification, had greater than 4X the ash level needed for this project, and prior to this work there was not a clear path of how to achieve the purity target. The lab scale development of LBCF was performed with a specific functional application in mind, specifically for high temperature rigid insulation. GTI is currently a consumer of foreignsourced pitch and rayon based carbon fibers for use in its high temperature insulation products, and the motivation was that LBCF had potential to decrease costs and increase product competitiveness in the marketplace through lowered raw material costs, lowered energy costs, and decreased environmental footprint. At the end of this project, the Technology Readiness Level (TRL) remained at 5 for LBCF in high temperature insulation.

  19. Pooled HIV-1 viral load testing using dried blood spots to reduce the cost of monitoring antiretroviral treatment in a resource-limited setting.

    Science.gov (United States)

    Pannus, Pieter; Fajardo, Emmanuel; Metcalf, Carol; Coulborn, Rebecca M; Durán, Laura T; Bygrave, Helen; Ellman, Tom; Garone, Daniela; Murowa, Michael; Mwenda, Reuben; Reid, Tony; Preiser, Wolfgang

    2013-10-01

    Rollout of routine HIV-1 viral load monitoring is hampered by high costs and logistical difficulties associated with sample collection and transport. New strategies are needed to overcome these constraints. Dried blood spots from finger pricks have been shown to be more practical than the use of plasma specimens, and pooling strategies using plasma specimens have been demonstrated to be an efficient method to reduce costs. This study found that combination of finger-prick dried blood spots and a pooling strategy is a feasible and efficient option to reduce costs, while maintaining accuracy in the context of a district hospital in Malawi.

  20. Innovation Rather than Improvement: A Solvable High-Dimensional Model Highlights the Limitations of Scalar Fitness

    Science.gov (United States)

    Tikhonov, Mikhail; Monasson, Remi

    2018-01-01

    Much of our understanding of ecological and evolutionary mechanisms derives from analysis of low-dimensional models: with few interacting species, or few axes defining "fitness". It is not always clear to what extent the intuition derived from low-dimensional models applies to the complex, high-dimensional reality. For instance, most naturally occurring microbial communities are strikingly diverse, harboring a large number of coexisting species, each of which contributes to shaping the environment of others. Understanding the eco-evolutionary interplay in these systems is an important challenge, and an exciting new domain for statistical physics. Recent work identified a promising new platform for investigating highly diverse ecosystems, based on the classic resource competition model of MacArthur. Here, we describe how the same analytical framework can be used to study evolutionary questions. Our analysis illustrates how, at high dimension, the intuition promoted by a one-dimensional (scalar) notion of fitness can become misleading. Specifically, while the low-dimensional picture emphasizes organism cost or efficiency, we exhibit a regime where cost becomes irrelevant for survival, and link this observation to generic properties of high-dimensional geometry.

  1. Capital cost expenditure of high temperature latent and sensible thermal energy storage systems

    Science.gov (United States)

    Jacob, Rhys; Saman, Wasim; Bruno, Frank

    2017-06-01

    In the following study cost estimates have been undertaken for an encapsulated phase change material (EPCM) packed bed, a packed bed thermocline and a traditional two-tank molten salt system. The effect of various heat transfer fluids (air and molten salt), system configuration (cascade vs one PCM, and direct vs indirect) and temperature difference (ΔT = 100-500 °C) on the cost estimate of the system was also investigated. Lastly, the storage system boundary was expanded to include heat exchangers, pumps and fans, and heat tracing so that a thorough cost comparison could be undertaken. The results presented in this paper provide a methodology to quickly compare various systems and configurations while providing design limits for the studied technologies.

  2. Suppression of the sonic heat transfer limit in high-temperature heat pipes

    Science.gov (United States)

    Dobran, Flavio

    1989-08-01

    The design of high-performance heat pipes requires optimization of heat transfer surfaces and liquid and vapor flow channels to suppress the heat transfer operating limits. In the paper an analytical model of the vapor flow in high-temperature heat pipes is presented, showing that the axial heat transport capacity limited by the sonic heat transfer limit depends on the working fluid, vapor flow area, manner of liquid evaporation into the vapor core of the evaporator, and lengths of the evaporator and adiabatic regions. Limited comparisons of the model predictions with data of the sonic heat transfer limits are shown to be very reasonable, giving credibility to the proposed analytical approach to determine the effect of various parameters on the axial heat transport capacity. Large axial heat transfer rates can be achieved with large vapor flow cross-sectional areas, small lengths of evaporator and adiabatic regions or a vapor flow area increase in these regions, and liquid evaporation in the evaporator normal to the main flow.

  3. OA 2014-5 Dataset - Limited Entry and Open Access cost earnings survey collecting 2014-15 data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project collects economic data from vessel owners participating in the West Coast limited entry fixed gear and open access groundfish, salmon, crab, and shrimp...

  4. Suppression of Noise to Obtain a High-Performance Low-Cost Optical Encoder

    Directory of Open Access Journals (Sweden)

    Sergio Alvarez-Rodríguez

    2018-01-01

    Full Text Available Currently, commercial encoders endowed with high precision are expensive sensors, and optical low-cost designs to measure the positioning angle have undesirable levels of system noise which reduce the good performance of devices. This research is devoted to the designing of mathematical filters to suppress noise in polarized transducers, in order to obtain high accuracy, precision, and resolution, along with an adaptive maximum response speed for low-cost optical encoders. This design was proved through a prototype inside a research platform, and experimental results show an accuracy of 3.9, a precision of 26, and a resolution of 17 [arc seconds], at least for the specified working conditions, for the sensing of the angular position of a rotary polarizer. From this work has been obtained a high-performance low-cost polyphase optical encoder, which uses filtering mathematical principles potentially generalizable to other inventions.

  5. Bandwidth-limited control and ringdown suppression in high-Q resonators.

    Science.gov (United States)

    Borneman, Troy W; Cory, David G

    2012-12-01

    We describe how the transient behavior of a tuned and matched resonator circuit and a ringdown suppression pulse may be integrated into an optimal control theory (OCT) pulse-design algorithm to derive control sequences with limited ringdown that perform a desired quantum operation in the presence of resonator distortions of the ideal waveform. Inclusion of ringdown suppression in numerical pulse optimizations significantly reduces spectrometer deadtime when using high quality factor (high-Q) resonators, leading to increased signal-to-noise ratio (SNR) and sensitivity of inductive measurements. To demonstrate the method, we experimentally measure the free-induction decay of an inhomogeneously broadened solid-state free radical spin system at high Q. The measurement is enabled by using a numerically optimized bandwidth-limited OCT pulse, including ringdown suppression, robust to variations in static and microwave field strengths. We also discuss the applications of pulse design in high-Q resonators to universal control of anisotropic-hyperfine coupled electron-nuclear spin systems via electron-only modulation even when the bandwidth of the resonator is significantly smaller than the hyperfine coupling strength. These results demonstrate how limitations imposed by linear response theory may be vastly exceeded when using a sufficiently accurate system model to optimize pulses of high complexity. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. Network coupling via a current-limiting throttle with a high-Tc superconductor core

    International Nuclear Information System (INIS)

    Bochenek, E.; Fischer, R.; Lampen, U.; Voigt, H.

    1989-01-01

    A current-limiting concept is tested by means of a choke with a current-responsive inductivity for linking three-phase current supplies. The choke has a core of a material with a high transition point T c . In the case of nominal current, the core is superconductive and keeps the resulting inductance of the choke low by shield currents. In the case of overload, the core passes into the normal conductive state due to the increased magnetic field of the winding. The resulting inductance of the choke rises and, in doing so, effects current limitation. (orig.) [de

  7. Accuracy of a Low-Cost Novel Computer-Vision Dynamic Movement Assessment: Potential Limitations and Future Directions

    Science.gov (United States)

    McGroarty, M.; Giblin, S.; Meldrum, D.; Wetterling, F.

    2016-04-01

    The aim of the study was to perform a preliminary validation of a low cost markerless motion capture system (CAPTURE) against an industry gold standard (Vicon). Measurements of knee valgus and flexion during the performance of a countermovement jump (CMJ) between CAPTURE and Vicon were compared. After correction algorithms were applied to the raw CAPTURE data acceptable levels of accuracy and precision were achieved. The knee flexion angle measured for three trials using Capture deviated by -3.8° ± 3° (left) and 1.7° ± 2.8° (right) compared to Vicon. The findings suggest that low-cost markerless motion capture has potential to provide an objective method for assessing lower limb jump and landing mechanics in an applied sports setting. Furthermore, the outcome of the study warrants the need for future research to examine more fully the potential implications of the use of low-cost markerless motion capture in the evaluation of dynamic movement for injury prevention.

  8. Theory of factors limiting high gradient operation of warm accelerating structures

    Energy Technology Data Exchange (ETDEWEB)

    Nusinovich, Gregory S. [Univ. of Maryland, College Park, MD (United States)

    2014-07-22

    This report consists of two parts. In the first part we describe a study of the heating of microprotrusions on surfaces of accelerating structures. This ;process is believed to lead to breakdown in these structures. Our study revealed that for current accelerator parameters melting should not occur due to space charge limitations of the current emitted by a protrusion. The second part describes a novel concept to develop THz range sources based on harmonic cyclotron masers for driving future colliders. This work was stimulated by a recent request of SLAC to develop high power, high-efficiency sources of sub-THz radiation for future high-gradient accelerators.

  9. High performance H-mode plasmas at densities above the Greenwald limit

    International Nuclear Information System (INIS)

    Mahdavi, M.A.; Osborne, T.H.; Leonard, A.W.

    2001-01-01

    Densities up to 40 percent above the Greenwald limit are reproducibly achieved in high confinement (H ITER89p =2) ELMing H-mode discharges. Simultaneous gas fueling and divertor pumping were used to obtain these results. Confinement of these discharges, similar to moderate density H-mode, is characterized by a stiff temperature profile, and therefore sensitive to the density profile. A particle transport model is presented that explains the roles of divertor pumping and geometry for access to high densities. Energy loss per ELM at high density is a factor of five lower than predictions of an earlier scaling, based on data from lower density discharges. (author)

  10. Cost allocation model for distribution networks considering high penetration of distributed energy resources

    DEFF Research Database (Denmark)

    Soares, Tiago; Pereira, Fábio; Morais, Hugo

    2015-01-01

    The high penetration of distributed energy resources (DER) in distribution networks and the competitive environment of electricity markets impose the use of new approaches in several domains. The network cost allocation, traditionally used in transmission networks, should be adapted and used...... in the distribution networks considering the specifications of the connected resources. The main goal is to develop a fairer methodology trying to distribute the distribution network use costs to all players which are using the network in each period. In this paper, a model considering different type of costs (fixed......, losses, and congestion costs) is proposed comprising the use of a large set of DER, namely distributed generation (DG), demand response (DR) of direct load control type, energy storage systems (ESS), and electric vehicles with capability of discharging energy to the network, which is known as vehicle...

  11. Assessing Risk in Costing High-energy Accelerators: from Existing Projects to the Future Linear Collider

    CERN Document Server

    Lebrun, Philippe

    2010-01-01

    High-energy accelerators are large projects funded by public money, developed over the years and constructed via major industrial contracts both in advanced technology and in more conventional domains such as civil engineering and infrastructure, for which they often constitute one-of markets. Assessing their cost, as well as the risk and uncertainty associated with this assessment is therefore an essential part of project preparation and a justified requirement by the funding agencies. Stemming from the experience with large circular colliders at CERN, LEP and LHC, as well as with the Main Injector, the Tevatron Collider Experiments and Accelerator Upgrades, and the NOvA Experiment at Fermilab, we discuss sources of cost variance and derive cost risk assessment methods applicable to the future linear collider, through its two technical approaches for ILC and CLIC. We also address disparities in cost risk assessment imposed by regional differences in regulations, procedures and practices.

  12. The High Rise Low Cost Housing : Sustainable Neighbourhood Elements (Green Elements) in Malaysia

    Science.gov (United States)

    Wahi, Noraziah; Mohamad, Ismail; Mohamad Zin, Rosli; Munikanan, Vikneswaran; Junaini, Syahrizan

    2018-03-01

    The sustainable development is a vital measure to alleviate the greenhouse gas effect, global warming and any other environment issues. The sustainable neighbourhood concept is not new in Malaysia, However, the concept still needs attention and awareness from the stakeholders. This paper discusses on the sustainable neighbourhood elements specifically green elements application on the high rise low cost housing in Malaysia. Malaysia should have focused sustainable neighbourhood planning and design especially on the high rise low cost housing therefore the future generation can be benefited from this type development.

  13. Toward Low-Cost, High-Energy Density, and High-Power Density Lithium-Ion Batteries

    Science.gov (United States)

    Li, Jianlin; Du, Zhijia; Ruther, Rose E.; AN, Seong Jin; David, Lamuel Abraham; Hays, Kevin; Wood, Marissa; Phillip, Nathan D.; Sheng, Yangping; Mao, Chengyu; Kalnaus, Sergiy; Daniel, Claus; Wood, David L.

    2017-09-01

    Reducing cost and increasing energy density are two barriers for widespread application of lithium-ion batteries in electric vehicles. Although the cost of electric vehicle batteries has been reduced by 70% from 2008 to 2015, the current battery pack cost (268/kWh in 2015) is still >2 times what the USABC targets (125/kWh). Even though many advancements in cell chemistry have been realized since the lithium-ion battery was first commercialized in 1991, few major breakthroughs have occurred in the past decade. Therefore, future cost reduction will rely on cell manufacturing and broader market acceptance. This article discusses three major aspects for cost reduction: (1) quality control to minimize scrap rate in cell manufacturing; (2) novel electrode processing and engineering to reduce processing cost and increase energy density and throughputs; and (3) material development and optimization for lithium-ion batteries with high-energy density. Insights on increasing energy and power densities of lithium-ion batteries are also addressed.

  14. The impact of high-risk drivers and benefits of limiting their driving degree of freedom.

    Science.gov (United States)

    Habtemichael, Filmon G; de Picado-Santos, Luis

    2013-11-01

    The perception of drivers regarding risk-taking behaviour is widely varied. High-risk drivers are the segment of drivers who are disproportionately represented in the majority of crashes. This study examines the typologies of drivers in risk-taking behaviour, the common high-risk driving errors (speeding, close following, abrupt lane-changing and impaired driving), their safety consequences and the technological (ITS) devices for their detection and correction. Limiting the driving degree of freedom of high-risk drivers is proposed and its benefits on safety as well as traffic operations are quantified using VISSIM microscopic traffic simulation at various proportions of high-risk drivers; namely, 4%, 8% and 12%. Assessment of the safety benefits was carried out by using the technique of simulated vehicle conflicts which was validated against historic crashes, and reduction in travel time was used to quantify the operational benefits. The findings imply that limiting the freedom of high-risk drivers resulted in a reduction of crashes by 12%, 21% and 27% in congested traffic conditions; 9%, 13% and 18% in lightly congested traffic conditions as well as 9%, 10% and 17% in non-congested traffic conditions for high-risk drivers in proportions of 4%, 8% and 12% respectively. Moreover, the surrogate safety measures indicated that there was a reduction in crash severity levels. The operational benefits amounted to savings of nearly 1% in travel time for all the proportions of high-risk drivers considered. The study concluded that limiting the freedom of high-risk drivers has safety and operational benefits; though there could be social, legal and institutional concerns for its practical implementation. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Threshold effect under nonlinear limitation of the intensity of high-power light

    International Nuclear Information System (INIS)

    Tereshchenko, S A; Podgaetskii, V M; Gerasimenko, A Yu; Savel'ev, M S

    2015-01-01

    A model is proposed to describe the properties of limiters of high-power laser radiation, which takes into account the threshold character of nonlinear interaction of radiation with the working medium of the limiter. The generally accepted non-threshold model is a particular case of the threshold model if the threshold radiation intensity is zero. Experimental z-scan data are used to determine the nonlinear optical characteristics of media with carbon nanotubes, polymethine and pyran dyes, zinc selenide, porphyrin-graphene and fullerene-graphene. A threshold effect of nonlinear interaction between laser radiation and some of investigated working media of limiters is revealed. It is shown that the threshold model more adequately describes experimental z-scan data. (nonlinear optical phenomena)

  16. Notch size effects on high cycle fatigue limit stress of Udimet 720

    International Nuclear Information System (INIS)

    Ren Weiju; Nicholas, Theodore

    2003-01-01

    Notch size effects on the high cycle fatigue (HCF) limit stress of Ni-base superalloy Udimet 720 were investigated on cylindrical specimens with three notch sizes of the same stress concentration factor K t =2.74. The HCF limit stress corresponding to a life of 10 6 cycles was experimentally determined at a stress ratio of 0.1 and a frequency of 25 Hz at room temperature. The stresses were calculated using finite element analysis (FEA) and the specimens analyzed using scanning electron microscopy (SEM). Test results show that at the same K t value, notch size can slightly affect the HCF limit stress of U720 when notch root plasticity occurs. FEA and SEM results reveal that the notch size effects are influenced by a complicated combination of the stress and plastic strain fields at the notch tip, the nominal stress, and the effects of prior plastic deformation on fatigue crack initiation

  17. Cost-benefit analyses of supplementary measles immunisation in the highly immunized population of New Zealand.

    Science.gov (United States)

    Hayman, D T S; Marshall, J C; French, N P; Carpenter, T E; Roberts, M G; Kiedrzynski, T

    2017-09-05

    As endemic measles is eliminated from countries through increased immunisation, the economic benefits of enhanced immunisation programs may come into question. New Zealand has suffered from outbreaks after measles introductions from abroad and we use it as a model system to understand the benefits of catch up immunisation in highly immunised populations. We provide cost-benefit analyses for measles supplementary immunisation in New Zealand. We model outbreaks based on estimates of the basic reproduction number in the vaccinated population (R v , the number of secondary infections in a partially immunised population), based on the number of immunologically-naïve people at district and national levels, considering both pre- and post-catch up vaccination scenarios. Our analyses suggest that measles R v often includes or exceeds one (0.18-3.92) despite high levels of population immunity. We calculate the cost of the first 187 confirmed and probable measles cases in 2014 to be over NZ$1 million (∼US$864,200) due to earnings lost, case management and hospitalization costs. The benefit-cost ratio analyses suggest additional vaccination beyond routine childhood immunisation is economically efficient. Supplemental vaccination-related costs are required to exceed approximately US$66 to US$1877 per person, depending on different scenarios, before supplemental vaccination is economically inefficient. Thus, our analysis suggests additional immunisation beyond childhood programs to target naïve individuals is economically beneficial even when childhood immunisation rates are high. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Intertidal oysters reach their physiological limit in a future high-CO2 world.

    Science.gov (United States)

    Scanes, Elliot; Parker, Laura M; O'Connor, Wayne A; Stapp, Laura S; Ross, Pauline M

    2017-03-01

    Sessile marine molluscs living in the intertidal zone experience periods of internal acidosis when exposed to air (emersion) during low tide. Relative to other marine organisms, molluscs have been identified as vulnerable to future ocean acidification; however, paradoxically it has also been shown that molluscs exposed to high CO 2 environments are more resilient compared with those molluscs naive to CO 2 exposure. Two competing hypotheses were tested using a novel experimental design incorporating tidal simulations to predict the future intertidal limit of oysters in a high-CO 2 world; either high-shore oysters will be more tolerant of elevated P CO 2 because of their regular acidosis, or elevated P CO 2  will cause high-shore oysters to reach their limit. Sydney rock oysters, Saccostrea glomerata , were collected from the high-intertidal and subtidal areas of the shore and exposed in an orthogonal design to either an intertidal or a subtidal treatment at ambient or elevated P CO 2 , and physiological variables were measured. The combined treatment of tidal emersion and elevated P CO 2  interacted synergistically to reduce the haemolymph pH (pH e ) of oysters, and increase the P CO 2  in the haemolymph ( P e,CO 2 ) and standard metabolic rate. Oysters in the intertidal treatment also had lower condition and growth. Oysters showed a high degree of plasticity, and little evidence was found that intertidal oysters were more resilient than subtidal oysters. It is concluded that in a high-CO 2 world the upper vertical limit of oyster distribution on the shore may be reduced. These results suggest that previous studies on intertidal organisms that lacked tidal simulations may have underestimated the effects of elevated P CO 2 . © 2017. Published by The Company of Biologists Ltd.

  19. No speed limits in medical imaging and high-energy physics

    CERN Multimedia

    Rita Giuffredi & Tom Meyer

    2015-01-01

    Speed, or high time resolution, is becoming increasingly important, if not crucial, in the high-energy physics domain, both for particle acceleration and detection systems. Medical-imaging technology also vitally depends on high time resolution detection techniques, often the offspring of today’s large particle physics experiments. The four-year FP7 Marie Curie Training Project “PicoSEC-MCNet”, which draws to a close at the end of November, was designed to develop ultra-fast photon detectors for applications in both domains. The project has achieved important results that promise to trigger further developments in the years to come.   The PicoSEC-MCNet project participants. “New requirements in high-energy physics force us to push the limits of photon detection speed, as future high-luminosity accelerators will force us to cope with the unprecedentedly short bunch crossing intervals needed to produce sufficient luminosity,” explains Tom M...

  20. High-Cost Patients Had Substantial Rates Of Leaving Medicare Advantage And Joining Traditional Medicare.

    Science.gov (United States)

    Rahman, Momotazur; Keohane, Laura; Trivedi, Amal N; Mor, Vincent

    2015-10-01

    Medicare Advantage payment regulations include risk-adjusted capitated reimbursement, which was implemented to discourage favorable risk selection and encourage the retention of members who incur high costs. However, the extent to which risk-adjusted capitation has succeeded is not clear, especially for members using high-cost services not previously considered in assessments of risk selection. We examined the rates at which participants who used three high-cost services switched between Medicare Advantage and traditional Medicare. We found that the switching rate from 2010 to 2011 away from Medicare Advantage and to traditional Medicare exceeded the switching rate in the opposite direction for participants who used long-term nursing home care (17 percent versus 3 percent), short-term nursing home care (9 percent versus 4 percent), and home health care (8 percent versus 3 percent). These results were magnified among people who were enrolled in both Medicare and Medicaid. Our findings raise questions about the role of Medicare Advantage plans in serving high-cost patients with complex care needs, who account for a disproportionately high amount of total health care spending. Project HOPE—The People-to-People Health Foundation, Inc.

  1. Using self-organizing maps to determine observation threshold limit predictions in highly variant data

    Science.gov (United States)

    Paganoni, C.A.; Chang, K.C.; Robblee, M.B.

    2006-01-01

    A significant data quality challenge for highly variant systems surrounds the limited ability to quantify operationally reasonable limits on the data elements being collected and provide reasonable threshold predictions. In many instances, the number of influences that drive a resulting value or operational range is too large to enable physical sampling for each influencer, or is too complicated to accurately model in an explicit simulation. An alternative method to determine reasonable observation thresholds is to employ an automation algorithm that would emulate a human analyst visually inspecting data for limits. Using the visualization technique of self-organizing maps (SOM) on data having poorly understood relationships, a methodology for determining threshold limits was developed. To illustrate this approach, analysis of environmental influences that drive the abundance of a target indicator species (the pink shrimp, Farfantepenaeus duorarum) provided a real example of applicability. The relationship between salinity and temperature and abundance of F. duorarum is well documented, but the effect of changes in water quality upstream on pink shrimp abundance is not well understood. The highly variant nature surrounding catch of a specific number of organisms in the wild, and the data available from up-stream hydrology measures for salinity and temperature, made this an ideal candidate for the approach to provide a determination about the influence of changes in hydrology on populations of organisms.

  2. Stability Limits of High-Beta Plasmas in DIII-D

    International Nuclear Information System (INIS)

    Strait, E.J.

    2005-01-01

    Stability at high beta is an important requirement for a compact, economically attractive fusion reactor. DIII-D experiments have shown that ideal magnetohydrodynamic (MHD) theory is an accurate predictor of the ultimate stability limits for tokamaks, and the Troyon scaling law has provided a useful approximation of ideal stability limits for discharges with 'conventional' profiles. However, variation of the discharge shape, pressure profile, and current density profile can lead to ideal MHD beta limits that differ significantly from simple Troyon scaling. The need for profiles consistent with steady-state operation places an important additional constraint on plasma stability. Nonideal effects can also be important and must be taken into account. For example, neoclassical tearing modes (NTMs), resulting from plasma resistivity and the nonlinear effects of the bootstrap current, can become unstable at beta values well below the ideal MHD limit. DIII-D experiments are now entering a new era of unprecedented control over plasma stability, including suppression of NTMs by localized current drive at the island location, and direct feedback stabilization of kink modes with a resistive wall. The continuing development of physics understanding and control tools holds the potential for stable, steady-state fusion plasmas at high beta

  3. 75 FR 73972 - Medicaid Program; Cost Limit for Providers Operated by Units of Government and Provisions To...

    Science.gov (United States)

    2010-11-30

    ... District Court for the District of Columbia on May 23, 2008 in Alameda County Medical Center, et al. v... limit on reimbursement. On May 23, 2008, the United States District Court for the District of Columbia...), DHHS is removing the word ``nursing facilities'' replacing it with ``NFs.'' In Sec. 447.272(a)(1), DHHS...

  4. Considerations for Assessing the Appropriateness of High-Cost Pediatric Care in Low-Income Regions

    Directory of Open Access Journals (Sweden)

    Andrew C. Argent

    2018-03-01

    Full Text Available It may be difficult to predict the consequences of provision of high-cost pediatric care (HCC in low- and middle-income countries (LMICs, and these consequences may be different to those experienced in high-income countries. An evaluation of the implications of HCC in LMICs must incorporate considerations of the specific context in that country (population age profile, profile of disease, resources available, likely costs of the HCC, likely benefits that can be gained versus the costs that will be incurred. Ideally, the process that is followed in decision making around HCC should be transparent and should involve the communities that will be most affected by those decisions. It is essential that the impacts of provision of HCC are carefully monitored so that informed decisions can be made about future provision medical interventions.

  5. Sliver Solar Cells: High-Efficiency, Low-Cost PV Technology

    Directory of Open Access Journals (Sweden)

    Evan Franklin

    2007-01-01

    Full Text Available Sliver cells are thin, single-crystal silicon solar cells fabricated using standard fabrication technology. Sliver modules, composed of several thousand individual Sliver cells, can be efficient, low-cost, bifacial, transparent, flexible, shadow tolerant, and lightweight. Compared with current PV technology, mature Sliver technology will need 10% of the pure silicon and fewer than 5% of the wafer starts per MW of factory output. This paper deals with two distinct challenges related to Sliver cell and Sliver module production: providing a mature and robust Sliver cell fabrication method which produces a high yield of highly efficient Sliver cells, and which is suitable for transfer to industry; and, handling, electrically interconnecting, and encapsulating billions of sliver cells at low cost. Sliver cells with efficiencies of 20% have been fabricated at ANU using a reliable, optimised processing sequence, while low-cost encapsulation methods have been demonstrated using a submodule technique.

  6. Possibilities and limits of digital industrial radiology: the new high contrast sensitivity technique - Examples and system theoretical analysis

    International Nuclear Information System (INIS)

    Zscherpel, U.; Ewert, U.; Bavendiek, K.

    2007-01-01

    During the last years more and more reports about film replacement techniques are published using different ways to prove the required and obtained image quality. The motivation is usually cost reduction due to shorter exposure times and lower storage costs, smaller space requirements and elimination of chemical processing inclusive associated waste handling and disposal. There are no other publications known, which explore the upper limits of image quality achievable by the new digital techniques. This is important for inspection of safety relevant and high risk parts, as e.g. in nuclear or aerospace industries. A new calibration and measurement procedure for digital detector arrays (DDA) was explored to obtain the maximum signal/noise ratio achievable with DDAs. This procedure yields a contrast sensitivity which allows distinguishing wall thickness changes of up to 1/1000 of the penetrated material thickness. Standard film radiography using NDT film systems (with and without lead screens) achieves a wall thickness contrast which is not better than 1/100 even with the best film system class (class 'C1' according to EN 584-1 or 'special' according to ASTM E 1815). Computed Radiography (CR) using phosphor imaging plates is a true film replacement technique without enhancement of the image quality compared to NDT film systems. The comparison is based on parameter studies which measure signal/noise ratios and determine the basic spatial resolution as well as a comparison of radiological images with fine flaws. (authors)

  7. Limits to evaporation residue cross sections from fission and particle decay at high angular momentum

    International Nuclear Information System (INIS)

    Newton, J.O.

    1980-06-01

    In recent years there has been great interest in nuclear properties at very high angular momentum. The heavy-ion (HI),xnγ reaction and to a lesser extent the (HI,xn,ypγ) reactions, have so far offered the most powerful experimental technique for their study. Measurements on the resolved discrete γ-rays from the decay of yrast or near-yrast states has lead to considerable understanding of states with angular momenta up to a little over 20h and in a few special cases as high as 37 h. To investigate nuclei at still higher angular angular momenta one can study the so called 'continuum γ-rays', which cannot be resolved by present techniques because so many pathways are involved. The author considers the factors which determine the upper limits of the angular momenta for which continuum γ-ray studies can be usefully employed and how one may gain information beyond these limits

  8. Forming limit diagram of aluminum AA6063 tubes at high temperatures by bulge tests

    International Nuclear Information System (INIS)

    Hashemi, Seyed Jalal; Naeini, Hassan Moslemi; Liaghat, Gholamhossein; Tafti, Rooholla Azizi; Rahmani, Farzad

    2014-01-01

    A free bulge test and ductile fracture criteria were used to obtain the forming limit diagrams (FLD) of aluminum alloy AA6063 tubes at high temperatures. Ductile fracture criteria were calibrated using the results of uniaxial tension tests at various elevated temperatures and different strain rates through adjusting the Zener-Holloman parameter. High temperature free bulge test of tubes was simulated in finite element software Abaqus, and tube bursting was predicted using ductile fracture criteria under different loading paths. FLDs which were obtained from finite element simulation were compared to experimental results to select the most accurate criterion for prediction of forming limit diagram. According to the results, all studied ductile fracture criteria predict similarly when forming condition is close to the uniaxial tension, while Ayada criterion predicts the FLD at 473 K and 573 K very well.

  9. Forming limit diagram of aluminum AA6063 tubes at high temperatures by bulge tests

    Energy Technology Data Exchange (ETDEWEB)

    Hashemi, Seyed Jalal; Naeini, Hassan Moslemi; Liaghat, Gholamhossein [Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Tafti, Rooholla Azizi [Yazd University, Yazd (Iran, Islamic Republic of); Rahmani, Farzad [Kar Higher Education Institute, Qazvin (Iran, Islamic Republic of)

    2014-11-15

    A free bulge test and ductile fracture criteria were used to obtain the forming limit diagrams (FLD) of aluminum alloy AA6063 tubes at high temperatures. Ductile fracture criteria were calibrated using the results of uniaxial tension tests at various elevated temperatures and different strain rates through adjusting the Zener-Holloman parameter. High temperature free bulge test of tubes was simulated in finite element software Abaqus, and tube bursting was predicted using ductile fracture criteria under different loading paths. FLDs which were obtained from finite element simulation were compared to experimental results to select the most accurate criterion for prediction of forming limit diagram. According to the results, all studied ductile fracture criteria predict similarly when forming condition is close to the uniaxial tension, while Ayada criterion predicts the FLD at 473 K and 573 K very well.

  10. Comparison of costs for solidification of high-level radioactive waste solutions: glass monoliths vs metal matrices

    International Nuclear Information System (INIS)

    Jardine, L.J.; Carlton, R.E.; Steindler, M.J.

    1981-05-01

    A comparative economic analysis was made of four solidification processes for liquid high-level radioactive waste. Two processes produced borosilicate glass monoliths and two others produced metal matrix composites of lead and borosilicate glass beads and lead and supercalcine pellets. Within the uncertainties of the cost (1979 dollars) estimates, the cost of the four processes was about the same, with the major cost component being the cost of the primary building structure. Equipment costs and operating and maintenance costs formed only a small portion of the building structure costs for all processes

  11. Limitations of cost-benefit evaluation of non-systematic radiological screening of congenital dislocatable or dislocated hip in Germany

    International Nuclear Information System (INIS)

    Weidtman, V.; Heereman, B. von; Herrmann, F.

    1987-01-01

    Cost-benefit analyses in the field of screening procedures not only comprise economic aspects, but they also require a thorough analysis of possible health risks, which are imminent in these examinations. Many publications on this topic during the past years have proven that even in such a well investigated problem, like the dislocated or dislocatable hip, this can lead to difficulties. We encountered in Germany these questions connected to hip joint screening, when we tried to analyse the data from the German General Screening Program (GGSP). It ws found that 10 times as many children were treated than one would have expected from epidemiological data. In addition a similarly large number of tentative diagnoses was found, which in summary caused great concern amongst the interested social pediatricians. It was to be expected, that the special examinations and treatments resulting from the screening of children had caused considerable and partially useless costs and unnecessary x-ray exposures. Considerable concern was stirred by information from orthopedic clinics, which reported that still cases of hip luxations and hip dysplasias are seen past the half year margin

  12. Cost effectiveness of option B plus for prevention of mother-to-child transmission of HIV in resource-limited countries: evidence from Kumasi, Ghana.

    Science.gov (United States)

    VanDeusen, Adam; Paintsil, Elijah; Agyarko-Poku, Thomas; Long, Elisa F

    2015-03-18

    Achieving the goal of eliminating mother-to-child HIV transmission (MTCT) necessitates increased access to antiretroviral therapy (ART) for HIV-infected pregnant women. Option B provides ART through pregnancy and breastfeeding, whereas Option B+ recommends continuous ART regardless of CD4 count, thus potentially reducing MTCT during future pregnancies. Our objective was to compare maternal and pediatric health outcomes and cost-effectiveness of Option B+ versus Option B in Ghana. A decision-analytic model was developed to simulate HIV progression in mothers and transmission (in utero, during birth, or through breastfeeding) to current and all future children. Clinical parameters, including antenatal care access and fertility rates, were estimated from a retrospective review of 817 medical records at two hospitals in Ghana. Additional parameters were obtained from published literature. Modeled outcomes include HIV infections averted among newborn children, quality-adjusted life-years (QALYs), and cost-effectiveness ratios. HIV-infected women in Ghana have a lifetime average of 2.3 children (SD 1.3). Projected maternal life expectancy under Option B+ is 16.1 years, versus 16.0 years with Option B, yielding a gain of 0.1 maternal QALYs and 3.2 additional QALYs per child. Despite higher initial ART costs, Option B+ costs $785/QALY gained, a value considered very cost-effective by World Health Organization benchmarks. Widespread implementation of Option B+ in Ghana could theoretically prevent up to 668 HIV infections among children annually. Cost-effectiveness estimates remained favorable over robust sensitivity analyses. Although more expensive than Option B, Option B+ substantially reduces MTCT in future pregnancies, increases both maternal and pediatric QALYs, and is a cost-effective use of limited resources in Ghana.

  13. Theory of the high-frequency limiting viscosity of a dilute polymer solution. Pt. 2

    Energy Technology Data Exchange (ETDEWEB)

    Doi, M; Nakajima, H; Wada, Y

    1976-06-01

    High-frequency limiting viscosities of dilute polymer solutions are calculated on the basis of the author's previous theory for (1) necklace model of a chain with constant bond length and bond angle under a hindering rotational potential, and (2) broken rod model consisting of N rods with equal length connected by universal joints. Exact treatment is possible for a once-broken rod model, but the Monte Carlo method is used in the other calculations.

  14. A high efficiency, high quality and low cost internal regulated bioanalytical laboratory to support drug development needs.

    Science.gov (United States)

    Song, Yan; Dhodda, Raj; Zhang, Jun; Sydor, Jens

    2014-05-01

    In the recent past, we have seen an increase in the outsourcing of bioanalysis in pharmaceutical companies in support of their drug development pipeline. This trend is largely driven by the effort to reduce internal cost, especially in support of late-stage pipeline assets where established bioanalytical assays are used to analyze a large volume of samples. This article will highlight our perspective of how bioanalytical laboratories within pharmaceutical companies can be developed into the best partner in the advancement of drug development pipelines with high-quality support at competitive cost.

  15. Linear versus non-linear structural information limit in high-resolution transmission electron microscopy

    International Nuclear Information System (INIS)

    Van Aert, S.; Chen, J.H.; Van Dyck, D.

    2010-01-01

    A widely used performance criterion in high-resolution transmission electron microscopy (HRTEM) is the information limit. It corresponds to the inverse of the maximum spatial object frequency that is linearly transmitted with sufficient intensity from the exit plane of the object to the image plane and is limited due to partial temporal coherence. In practice, the information limit is often measured from a diffractogram or from Young's fringes assuming a weak phase object scattering beyond the inverse of the information limit. However, for an aberration corrected electron microscope, with an information limit in the sub-angstrom range, weak phase objects are no longer applicable since they do not scatter sufficiently in this range. Therefore, one relies on more strongly scattering objects such as crystals of heavy atoms observed along a low index zone axis. In that case, dynamical scattering becomes important such that the non-linear and linear interaction may be equally important. The non-linear interaction may then set the experimental cut-off frequency observed in a diffractogram. The goal of this paper is to quantify both the linear and the non-linear information transfer in terms of closed form analytical expressions. Whereas the cut-off frequency set by the linear transfer can be directly related with the attainable resolution, information from the non-linear transfer can only be extracted using quantitative, model-based methods. In contrast to the historic definition of the information limit depending on microscope parameters only, the expressions derived in this paper explicitly incorporate their dependence on the structure parameters as well. In order to emphasize this dependence and to distinguish from the usual information limit, the expressions derived for the inverse cut-off frequencies will be referred to as the linear and non-linear structural information limit. The present findings confirm the well-known result that partial temporal coherence has

  16. Flooding-limited thermal mixing: The case of high-froude number injection

    International Nuclear Information System (INIS)

    Iyer, K.; Theofanous, T.G.

    1985-01-01

    The stratification in the cold leg due to high pressure injection in a stagnated loop of a PWR is considered. The working hypothesis is that at high injection Froude numbers the extent of mixing approaches a limit controlled only by the flooding condition at the cold leg exit. The available experimental data support this hypothesis. Predictions for reactor conditions indicate a stratification of about --40 0 C. As a consequence, the downcomer plume would be rather weak (low Froude Number) and is expected to decay quickly

  17. Sparking limits, cavity loading, and beam breakup instability associated with high-current rf linacs

    International Nuclear Information System (INIS)

    Faehl, R.J.; Lemons, D.S.; Thode, L.E.

    1982-01-01

    The limitations on high-current rf linacs due to gap sparking, cavity loading, and the beam breakup instability are studied. It appears possible to achieve cavity accelerating gradients as high as 35 MV/m without sparking. Furthermore, a linear analysis, as well as self-consistent particle simulations of a multipulsed 10 kA beam, indicated that only a negligible small fraction of energy is radiated into nonfundamental cavity modes. Finally, the beam breakup instability is analyzed and found to be able to magnify initial radial perturbations by a factor of no more than about 20 during the beam transit time through a 1 GeV accelerator

  18. Low-cost, High Flexibility I-V Curve Tracer for Photovoltaic Modules

    DEFF Research Database (Denmark)

    Ibirriaga, Julen Joseba Maestro; Pena, Xabier Miquelez de Mendiluce; Opritescu, Adrian

    2010-01-01

    This work presents the design, construction and test of an in-door low cost, high flexibility I-V curve tracer for photovoltaic modules. The tracer is connected to a Xenon lamp based flashing solar simulator. The designed tracer is able to deal with the very fast changing irradiation conditions...

  19. The Cost of Empathy: Parent-Adolescent Conflict Predicts Emotion Dysregulation for Highly Empathic Youth

    Science.gov (United States)

    Van Lissa, Caspar J.; Hawk, Skyler T.; Koot, Hans M.; Branje, Susan; Meeus, Wim H. J.

    2017-01-01

    Empathy plays a key role in maintaining close relationships and promoting prosocial conflict resolution. However, research has not addressed the potential emotional cost of adolescents' high empathy, particularly when relationships are characterized by more frequent conflict. The present 6-year longitudinal study (N = 467) investigated whether…

  20. 78 FR 16808 - Connect America Fund; High-Cost Universal Service Support

    Science.gov (United States)

    2013-03-19

    ... USF/ ICC Transformation Order, including granting in part requests to modify the high cost loop... 27, 2013. The full text of this document is available for public inspection during regular business... following Internet address: http://transition.fcc.gov/Daily_Releases/Daily_Business/2013/db0227/FCC-13-16A1...

  1. What factors increase the risk of incurring high market impact costs?

    NARCIS (Netherlands)

    Bikker, Jacob A.; Spierdijk, L.; van der Sluis, Pieter Jelle

    2010-01-01

    This article applies quantile regression to assess the factors that influence the risk of incurring high trading costs. Using data on the equity trades of the world’s second largest pension fund in the first quarter of 2002, we show that trade timing, momentum, volatility and the type of broker

  2. Total and Marginal Cost Analysis for a High School Based Bystander Intervention

    Science.gov (United States)

    Bush, Joshua L.; Bush, Heather M.; Coker, Ann L.; Brancato, Candace J.; Clear, Emily R.; Recktenwald, Eileen A.

    2018-01-01

    Costs of providing the Green Dot bystander-based intervention, shown to be effective in the reduction of sexual violence among Kentucky high school students, were estimated based on data from a large cluster-randomized clinical trial. Rape Crisis Center Educators were trained to provide Green Dot curriculum to students. Implementing Green Dot in…

  3. What factors increase the risk of incurring high market impact costs?

    NARCIS (Netherlands)

    Bikker, Jacob A.; Spierdijk, Laura; van der Sluis, Pieter-Jelle

    2010-01-01

    This article applies quantile regression to assess the factors that influence the risk of incurring high trading costs. Using data on the equity trades of the world's second largest pension fund in the first quarter of 2002, we show that trade timing, momentum, volatility and the type of broker

  4. Case mix-adjusted cost of colectomy at low-, middle-, and high-volume academic centers.

    Science.gov (United States)

    Chang, Alex L; Kim, Young; Ertel, Audrey E; Hoehn, Richard S; Wima, Koffi; Abbott, Daniel E; Shah, Shimul A

    2017-05-01

    Efforts to regionalize surgery based on thresholds in procedure volume may have consequences on the cost of health care delivery. This study aims to delineate the relationship between hospital volume, case mix, and variability in the cost of operative intervention using colectomy as the model. All patients undergoing colectomy (n = 90,583) at 183 academic hospitals from 2009-2012 in The University HealthSystems Consortium Database were studied. Patient and procedure details were used to generate a case mix-adjusted predictive model of total direct costs. Observed to expected costs for each center were evaluated between centers based on overall procedure volume. Patient and procedure characteristics were significantly different between volume tertiles. Observed costs at high-volume centers were less than at middle- and low-volume centers. According to our predictive model, high-volume centers cared for a less expensive case mix than middle- and low-volume centers ($12,786 vs $13,236 and $14,497, P case mix at low-volume centers, which may lead to perceived poor performance at these centers. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Calculation of high-rise construction limitations for non-resident housing fund in megacities

    Directory of Open Access Journals (Sweden)

    Iliashenko Oksana

    2018-01-01

    Full Text Available The paper is devoted to topical issues of urban planning in terms of high-rise construction of a non-resident housing stock in relation to megacities. We consider this issue taking into account the limitations of natural, communal and social resources. The problem is especially acute for the overwhelming majority of the state capitals, as well as cities with historical heritage that are of great interest due to the rapid development of tourism and the high mobility of the population in the world. The growth of the population of many states capitals led to the use of high-rise buildings as a non-resident housing stock. However, there are a number of restrictions on the high-rise construction of non-resident housing stock in megacities. The authors formalize the problem of determining the optimal ratio of the volume of urban buildings belonging to the high-rise buildings types and intended for non-residents to a common housing fund. We conduct economic calculations to determine the quantitative indicators. It can be used as the basis for administrative measures aimed at limiting the people flow arriving with the intention of temporarily deploying in megacities.

  6. A proposal for limited criminal liability in high-accuracy endoscopic sinus surgery.

    Science.gov (United States)

    Voultsos, P; Casini, M; Ricci, G; Tambone, V; Midolo, E; Spagnolo, A G

    2017-02-01

    The aim of the present study is to propose legal reform limiting surgeons' criminal liability in high-accuracy and high-risk surgery such as endoscopic sinus surgery (ESS). The study includes a review of the medical literature, focusing on identifying and examining reasons why ESS carries a very high risk of serious complications related to inaccurate surgical manoeuvers and reviewing British and Italian legal theory and case-law on medical negligence, especially with regard to Italian Law 189/2012 (so called "Balduzzi" Law). It was found that serious complications due to inaccurate surgical manoeuvers may occur in ESS regardless of the skill, experience and prudence/diligence of the surgeon. Subjectivity should be essential to medical negligence, especially regarding high-accuracy surgery. Italian Law 189/2012 represents a good basis for the limitation of criminal liability resulting from inaccurate manoeuvres in high-accuracy surgery such as ESS. It is concluded that ESS surgeons should be relieved of criminal liability in cases of simple/ordinary negligence where guidelines have been observed. © Copyright by Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale, Rome, Italy.

  7. Calculation of high-rise construction limitations for non-resident housing fund in megacities

    Science.gov (United States)

    Iliashenko, Oksana; Krasnov, Sergey; Sergeev, Sergey

    2018-03-01

    The paper is devoted to topical issues of urban planning in terms of high-rise construction of a non-resident housing stock in relation to megacities. We consider this issue taking into account the limitations of natural, communal and social resources. The problem is especially acute for the overwhelming majority of the state capitals, as well as cities with historical heritage that are of great interest due to the rapid development of tourism and the high mobility of the population in the world. The growth of the population of many states capitals led to the use of high-rise buildings as a non-resident housing stock. However, there are a number of restrictions on the high-rise construction of non-resident housing stock in megacities. The authors formalize the problem of determining the optimal ratio of the volume of urban buildings belonging to the high-rise buildings types and intended for non-residents to a common housing fund. We conduct economic calculations to determine the quantitative indicators. It can be used as the basis for administrative measures aimed at limiting the people flow arriving with the intention of temporarily deploying in megacities.

  8. Measurements of soil, surface water, and groundwater CO2 concentration variability within Earth's critical zone: low-cost, long-term, high-temporal resolution monitoring

    Science.gov (United States)

    Blackstock, J. M.; Covington, M. D.; Williams, S. G. W.; Myre, J. M.; Rodriguez, J.

    2017-12-01

    Variability in CO2 fluxes within Earth's Critical zone occurs over a wide range of timescales. Resolving this and its drivers requires high-temporal resolution monitoring of CO2 both in the soil and aquatic environments. High-cost (> 1,000 USD) gas analyzers and data loggers present cost-barriers for investigations with limited budgets, particularly if high spatial resolution is desired. To overcome high-costs, we developed an Arduino based CO2 measuring platform (i.e. gas analyzer and data logger). The platform was deployed at multiple sites within the Critical Zone overlying the Springfield Plateau aquifer in Northwest Arkansas, USA. The CO2 gas analyzer used in this study was a relatively low-cost SenseAir K30. The analyzer's optical housing was covered by a PTFE semi-permeable membrane allowing for gas exchange between the analyzer and environment. Total approximate cost of the monitoring platform was 200 USD (2% detection limit) to 300 USD (10% detection limit) depending on the K30 model used. For testing purposes, we deployed the Arduino based platform alongside a commercial monitoring platform. CO2 concentration time series were nearly identical. Notably, CO2 cycles at the surface water site, which operated from January to April 2017, displayed a systematic increase in daily CO2 amplitude. Preliminary interpretation suggests key observation of seasonally increasing stream metabolic function. Other interpretations of observed cyclical and event-based behavior are out of the scope of the study; however, the presented method describes an accurate near-hourly characterization of CO2 variability. The new platform has been shown to be operational for several months, and we infer reliable operation for much longer deployments (> 1 year) given adequate environmental protection and power supply. Considering cost-savings, this platform is an attractive option for continuous, accurate, low-power, and low-cost CO2 monitoring for remote locations, globally.

  9. The clinical and economic impact of point-of-care CD4 testing in mozambique and other resource-limited settings: a cost-effectiveness analysis.

    Directory of Open Access Journals (Sweden)

    Emily P Hyle

    2014-09-01

    Full Text Available Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to laboratory-based tests in Mozambique.We use a validated model of HIV testing, linkage, and treatment (CEPAC-International to examine two strategies of immunological staging in Mozambique: (1 laboratory-based CD4 testing (LAB-CD4 and (2 point-of-care CD4 testing (POC-CD4. Model outcomes include 5-y survival, life expectancy, lifetime costs, and incremental cost-effectiveness ratios (ICERs. Input parameters include linkage to care (LAB-CD4, 34%; POC-CD4, 61%, probability of correctly detecting antiretroviral therapy (ART eligibility (sensitivity: LAB-CD4, 100%; POC-CD4, 90% or ART ineligibility (specificity: LAB-CD4, 100%; POC-CD4, 85%, and test cost (LAB-CD4, US$10; POC-CD4, US$24. In sensitivity analyses, we vary POC-CD4-specific parameters, as well as cohort and setting parameters to reflect a range of scenarios in sub-Saharan Africa. We consider ICERs less than three times the per capita gross domestic product in Mozambique (US$570 to be cost-effective, and ICERs less than one times the per capita gross domestic product in Mozambique to be very cost-effective. Projected 5-y survival in HIV-infected persons with LAB-CD4 is 60.9% (95% CI, 60.9%-61.0%, increasing to 65.0% (95% CI, 64.9%-65.1% with POC-CD4. Discounted life expectancy and per person lifetime costs with LAB-CD4 are 9.6 y (95% CI, 9.6-9.6 y and US$2,440 (95% CI, US$2,440-US$2,450 and increase with POC-CD4 to 10.3 y (95% CI, 10.3-10.3 y and US$2,800 (95% CI, US$2,790-US$2,800; the ICER of POC-CD4 compared to LAB-CD4 is US$500/year of life saved (YLS (95% CI, US$480-US$520/YLS. POC-CD4 improves clinical outcomes and remains near the very cost-effective threshold in sensitivity analyses, even if point-of-care CD4 tests have lower sensitivity/specificity and higher cost than published

  10. The High Luminosity Challenge: potential and limitations of High Intensity High Brightness in the LHC and its injectors

    CERN Document Server

    De Maria, R; Banfi, D; Barranco, J; Bartosik, H; Benedetto, E; Bruce, R; Brüning, O; Calaga, R; Cerutti, F; Damerau, H; Esposito, L; Fartoukh, S; Fitterer, M; Garoby, R; Gilardoni, S; Giovannozzi, M; Goddard, B; Gorini, B; Hanke, K; Iadarola, G; Lamont, M; Meddahi, M; Métral, E; Mikulec, B; Mounet, N; Papaphilippou, Y; Pieloni, T; Redaelli, S; Rossi, L; Rumolo, G; Shaposhnikova, E; Sterbini, G; Todesco, E; Tomás, R; Zimmermann, F; Valishev, A

    2014-01-01

    High-intensity and high-brightness beams are key ingredients to maximize the LHC integrated luminosity and to exploit its full potential. This contribution describes the optimization of beam and machine parameters to maximize the integrated luminosity as seen by the LHC experiments, by taking into account the expected intensity and brightness reach of LHC itself and its injector chain as well as the capabilities of the detectors for next run and foreseen upgrade scenarios.

  11. The modular high-temperature gas-cooled reactor: A cost/risk competitive nuclear option

    International Nuclear Information System (INIS)

    Gotschall, H.L.

    1994-01-01

    The business risks of nuclear plant ownership are identified as a constraint on the expanded use of nuclear power. Such risks stem from the exacting demands placed on owner/operator organizations of current plants to demonstrate ongoing compliance with safety regulations and the resulting high costs for operation and maintenance. This paper describes the Modular High-Temperature Gas-Cooled Reactor (MHTGR) design, competitive economics, and approach to reducing the business risks of nuclear plant ownership

  12. Cross-Continuum Tool Is Associated with Reduced Utilization and Cost for Frequent High-Need Users

    Directory of Open Access Journals (Sweden)

    Lauran Hardin

    2017-02-01

    Full Text Available Introduction: High-need, high-cost (HNHC patients can over-use acute care services, a pattern of behavior associated with many poor outcomes that disproportionately contributes to increased U.S. healthcare cost. Our objective was to reduce healthcare cost and improve outcomes by optimizing the system of care. We targeted HNHC patients and identified root causes of frequent healthcare utilization. We developed a crosscontinuum intervention process and a succinct tool called a Complex Care Map (CCM© that addresses fragmentation in the system and links providers to a comprehensive individualized analysis of the patient story and causes for frequent access to health services. Methods: Using a pre-/post-test design in which each subject served as his/her own historical control, this quality improvement project focused on determining if the interdisciplinary intervention called CCM© had an impact on healthcare utilization and costs for HNHC patients. We conducted the analysis between November 2012 and December 2015 at Mercy Health Saint Mary’s, a Midwestern urban hospital with greater than 80,000 annual emergency department (ED visits. All referred patients with three or more hospital visits (ED or inpatient [IP] in the 12 months prior to initiation of a CCM© (n=339 were included in the study. Individualized CCMs© were created and made available in the electronic medical record (EMR to all healthcare providers. We compared utilization, cost, social, and healthcare access variables from the EMR and cost-accounting system for 12 months before and after CCMs© implementation. We used both descriptive and limited inferential statistics. Results: ED mean visits decreased 43% (p<0.001, inpatient mean admissions decreased 44% (p<0.001, outpatient mean visits decreased 17% (p<0.001, computed tomography mean scans decreased 62% (p<0.001, and OBS/IP length of stay mean days decreased 41% (p<0.001. Gross charges decreased 45% (p<0.001, direct expenses

  13. Enhancement of lipid accumulation by oleaginous yeast through phosphorus limitation under high content of ammonia.

    Science.gov (United States)

    Huang, Xiangfeng; Luo, Huijuan; Mu, Tianshuai; Shen, Yi; Yuan, Ming; Liu, Jia

    2018-04-18

    Low concentrations of acetic acid were used as carbon source to cultivate Cryptococcus curvatus MUCL 29819 for lipid production under high content of ammonia. Phosphorus limitation combined with initial pH regulation (pH = 6) weakened inhibition of free ammonia and promoted lipid accumulation. In batch cultivation, the produced lipid content and yield was 30.3% and 0.92 g/L, higher than those under unlimited condition (18.3% and 0.64 g/L). The content of monounsaturated fatty acid also increased from 37.3% (unlimited condition) to 45.8% (phosphorus-limited condition). During sequencing batch cultivation (SBC), the lipid content reached up to 51.02% under phosphorus-limited condition while only 31.88% under unlimited condition, which can be explained by the higher conversion efficiency of the carbon source to lipid. The total energy consumption including lipid extraction, transesterification and purification was 7.47 and 8.33 GJ under phosphorus-limited and unlimited condition, respectively. Copyright © 2018. Published by Elsevier Ltd.

  14. Low-cost, highly transparent flexible low-e coating film to enable electrochromic windows with increased energy savings

    Energy Technology Data Exchange (ETDEWEB)

    Berland, Brian [ITN Energy Systems, Inc., Littleton, CO (United States); Hollingsworth, Russell [ITN Energy Systems, Inc., Littleton, CO (United States)

    2015-03-31

    Five Quads of energy are lost through windows annually in the U.S. Low-e coatings are increasingly employed to reduce the wasted energy. Most commonly, the low-e coating is an oxide material applied directly to the glass at high temperature. With over 100,000,000 existing homes, a retrofit product is crucial to achieve widespread energy savings. Low-e films, i.e. coatings on polymeric substrates, are now also available to meet this need. However, the traditional oxide materials and process is incompatible with low temperature plastics. Alternate high performing low-e films typically incorporate materials that limit visible transmission to 35% or less. Further, the cost is high. The objective of this award was to develop a retrofit, integrated low-e/electrochromic window film to dramatically reduce energy lost through windows. While field testing of state-of-the-art electrochromic (EC) windows show the energy savings are maximized if a low-e coating is used in conjunction with the EC, available low-e films have a low visible transmission (~70% or less) that limits the achievable clear state and therefore, appearance and energy savings potential. Comprehensive energy savings models were completed at Lawrence Berkeley National Lab (LBNL). A parametric approach was used to project energy usage for windows with a large range of low-e properties across all U.S. climate zones, without limiting the study to materials that had already been produced commercially or made in a lab. The model enables projection of energy savings for low-e films as well as integrated low-e/EC products. This project developed a novel low-e film, optimized for compatibility with EC windows, using low temperature, high deposition rate processes for the growth of low-e coatings on plastic films by microwave plasma enhanced chemical vapor deposition. Silica films with good density and optical properties were demonstrated at deposition rates as high as 130Å/sec. A simple bi-layer low-e stack of

  15. Assessing Patient Activation among High-Need, High-Cost Patients in Urban Safety Net Care Settings.

    Science.gov (United States)

    Napoles, Tessa M; Burke, Nancy J; Shim, Janet K; Davis, Elizabeth; Moskowitz, David; Yen, Irene H

    2017-12-01

    We sought to examine the literature using the Patient Activation Measure (PAM) or the Patient Enablement Instrument (PEI) with high-need, high-cost (HNHC) patients receiving care in urban safety net settings. Urban safety net care management programs serve low-income, racially/ethnically diverse patients living with multiple chronic conditions. Although many care management programs track patient progress with the PAM or the PEI, it is not clear whether the PAM or the PEI is an effective and appropriate tool for HNHC patients receiving care in urban safety net settings in the United States. We searched PubMed, EMBASE, Web of Science, and PsycINFO for articles published between 2004 and 2015 that used the PAM and between 1998 and 2015 that used the PEI. The search was limited to English-language articles conducted in the United States and published in peer-reviewed journals. To assess the utility of the PAM and the PEI in urban safety net care settings, we defined a HNHC patient sample as racially/ethnically diverse, low socioeconomic status (SES), and multimorbid. One hundred fourteen articles used the PAM. All articles using the PEI were conducted outside the U.S. and therefore were excluded. Nine PAM studies (8%) included participants similar to those receiving care in urban safety net settings, three of which were longitudinal. Two of the three longitudinal studies reported positive changes following interventions. Our results indicate that research on patient activation is not commonly conducted on racially and ethnically diverse, low SES, and multimorbid patients; therefore, there are few opportunities to assess the appropriateness of the PAM in such populations. Investigators expressed concerns with the potential unreliability and inappropriate nature of the PAM on multimorbid, older, and low-literacy patients. Thus, the PAM may not be able to accurately assess patient progress among HNHC patients receiving care in urban safety net settings. Assessing

  16. Patient-Facing Mobile Apps to Treat High-Need, High-Cost Populations: A Scoping Review.

    Science.gov (United States)

    Singh, Karandeep; Drouin, Kaitlin; Newmark, Lisa P; Filkins, Malina; Silvers, Elizabeth; Bain, Paul A; Zulman, Donna M; Lee, Jae-Ho; Rozenblum, Ronen; Pabo, Erika; Landman, Adam; Klinger, Elissa V; Bates, David W

    2016-12-19

    Self-management is essential to caring for high-need, high-cost (HNHC) populations. Advances in mobile phone technology coupled with increased availability and adoption of health-focused mobile apps have made self-management more achievable, but the extent and quality of the literature supporting their use is not well defined. The purpose of this review was to assess the breadth, quality, bias, and types of outcomes measured in the literature supporting the use of apps targeting HNHC populations. Data sources included articles in PubMed and MEDLINE (National Center for Biotechnology Information), EMBASE (Elsevier), the Cochrane Central Register of Controlled Trials (EBSCO), Web of Science (Thomson Reuters), and the NTIS (National Technical Information Service) Bibliographic Database (EBSCO) published since 2008. We selected studies involving use of patient-facing iOS or Android mobile health apps. Extraction was performed by 1 reviewer; 40 randomly selected articles were evaluated by 2 reviewers to assess agreement. Our final analysis included 175 studies. The populations most commonly targeted by apps included patients with obesity, physical handicaps, diabetes, older age, and dementia. Only 30.3% (53/175) of the apps studied in the reviewed literature were identifiable and available to the public through app stores. Many of the studies were cross-sectional analyses (42.9%, 75/175), small (median number of participants=31, interquartile range 11.0-207.2, maximum 11,690), or performed by an app's developers (61.1%, 107/175). Of the 175 studies, only 36 (20.6%, 36/175) studies evaluated a clinical outcome. Most apps described in the literature could not be located on the iOS or Android app stores, and existing research does not robustly evaluate the potential of mobile apps. Whereas apps may be useful in patients with chronic conditions, data do not support this yet. Although we had 2-3 reviewers to screen and assess abstract eligibility, only 1 reviewer abstracted

  17. Exploring the Limits of High Altitude GPS for Future Lunar Missions

    Science.gov (United States)

    Ashman, Benjamin W.; Parker, Joel J. K.; Bauer, Frank H.; Esswein, Michael

    2018-01-01

    An increasing number of spacecraft are relying on the Global Positioning System (GPS) for navigation at altitudes near or above the GPS constellation itself - the region known as the Space Service Volume (SSV). While the formal definition of the SSV ends at geostationary altitude, the practical limit of high-altitude space usage is not known, and recent missions have demonstrated that signal availability is sufficient for operational navigation at altitudes halfway to the moon. This paper presents simulation results based on a high-fidelity model of the GPS constellation, calibrated and validated through comparisons of simulated GPS signal availability and strength with flight data from recent high-altitude missions including the Geostationary Operational Environmental Satellite 16 (GOES-16) and the Magnetospheric Multiscale (MMS) mission. This improved model is applied to the transfer to a lunar near-rectilinear halo orbit (NRHO) of the class being considered for the international Deep Space Gateway concept. The number of GPS signals visible and their received signal strengths are presented as a function of receiver altitude in order to explore the practical upper limit of high-altitude space usage of GPS.

  18. Adaptation of superconducting fault current limiter to high-speed reclosing

    International Nuclear Information System (INIS)

    Koyama, T.; Yanabu, S.

    2009-01-01

    Using a high temperature superconductor, we constructed and tested a model superconducting fault current limiter (SFCL). The superconductor might break in some cases because of its excessive generation of heat. Therefore, it is desirable to interrupt early the current that flows to superconductor. So, we proposed the SFCL using an electromagnetic repulsion switch which is composed of a superconductor, a vacuum interrupter and a by-pass coil, and its structure is simple. Duration that the current flow in the superconductor can be easily minimized to the level of less than 0.5 cycle using this equipment. On the other hand, the fault current is also easily limited by large reactance of the parallel coil. There is duty of high-speed reclosing after interrupting fault current in the electric power system. After the fault current is interrupted, the back-up breaker is re-closed within 350 ms. So, the electromagnetic repulsion switch should return to former state and the superconductor should be recovered to superconducting state before high-speed reclosing. Then, we proposed the SFCL using an electromagnetic repulsion switch which employs our new reclosing function. We also studied recovery time of the superconductor, because superconductor should be recovered to superconducting state within 350 ms. In this paper, the recovery time characteristics of the superconducting wire were investigated. Also, we combined the superconductor with the electromagnetic repulsion switch, and we did performance test. As a result, a high-speed reclosing within 350 ms was proven to be possible.

  19. Generation of forming limit bands for ultra-high-strength steels in car body structures

    Science.gov (United States)

    Bayat, Hamid Reza; Sarkar, Sayantan; Italiano, Francesco; Bach, Aleksandar; Wulfinghoff, Stephan; Reese, Stefanie

    2018-05-01

    The application of ultra-high-strength steels in safety-related automotive components has led to higher safety levels as well as weight reduction. Nevertheless, this class of advanced high-strength steels (AHSS) show material scatter due to its manufacturing processes. To address this problem in advance, it is of significance not only to model the failure of the sheet metal but also to specify a band for the necking regime. The former is described by a forming limit curve (FLC), whereas a forming limit band (FLB) introduces the upper and lower bounds for the permissible strains. The objective of the present work is to generate a robust prediction of the strain-based failure of the sheet metal during a car crash. The FLCs are generated numerically applying a modified Marciniak-Kuczynski (MK) model, where the existence of an angled groove is mandatory. This assures to obtain the maximum admissible strain. In addition, a zero extension angle is utilized for the left hand side of the FLC (tension-compression). The material scatter is captured in experiments and applied in the hardening relations. Necking strains are recorded experimentally by a digital image correlation based system (ARAMIS). Later, they are fit into the FLC based on an inhomogeneity parameter fi from the MK model. In order to generate a theoretical FLB, first a statistical approach is exploited to take the experimental data into consideration. Eventually, the forming limit band distinguishes between safe, necking and failed regions.

  20. Operational limits of high density H-modes in ASDEX Upgrade

    International Nuclear Information System (INIS)

    Mertens, V.; Borrass, K.; Kaufmann, M.; Lang, P.T.; Lang, R.; Mueller, H.W.; Neuhauser, J.; Schneider, R.; Schweinzer, J.; Suttrop, W.

    2001-01-01

    Systematic investigations of H-mode density limit (H→L-mode back transition) plasmas with gas fuelling and alternatively with additional pellet injection from the magnetic high-field-side HFS are being performed in the new closed divertor configuration DV-II. The resulting database covering a wide range of the externally controllable plasma parameters I p , B t and P heat confirms that the H-mode threshold power exceeds the generally accepted prediction P L→H heat ∝B-bar t dramatically when one approaches Greenwald densities. Additionally, in contrast to the Greenwald scaling a moderate B t -dependence of the H-mode density limit is found. The limit is observed to coincide with divertor detachment and a strong increase of the edge thermal transport, which has, however, no detrimental effect on global τ E . The pellet injection scheme from the magnetic high-field-side HFS, developed recently on ASDEX Upgrade, leads to fast particle drifts which are, contrary to the standard injection from the low-field-side, directed into the plasma core. This improves markedly the pellet particle fuelling efficiency. The responsible physical mechanism, the diamagnetic particle drift of the pellet ablatant was successfully verified recently. Other increased particle losses on respectively different time scales after the ablation process, however, still persist. Generally, a clear gain in achievable density and plasma stored energy is achieved with stationary HFS pellet injection compared to gas-puffing. (author)

  1. Evidence against the energetic cost hypothesis for the short introns in highly expressed genes

    Directory of Open Access Journals (Sweden)

    Niu Deng-Ke

    2008-05-01

    Full Text Available Abstract Background In animals, the moss Physcomitrella patens and the pollen of Arabidopsis thaliana, highly expressed genes have shorter introns than weakly expressed genes. A popular explanation for this is selection for transcription efficiency, which includes two sub-hypotheses: to minimize the energetic cost or to minimize the time cost. Results In an individual human, different organs may differ up to hundreds of times in cell number (for example, a liver versus a hypothalamus. Considered at the individual level, a gene specifically expressed in a large organ is actually transcribed tens or hundreds of times more than a gene with a similar expression level (a measure of mRNA abundance per cell specifically expressed in a small organ. According to the energetic cost hypothesis, the former should have shorter introns than the latter. However, in humans and mice we have not found significant differences in intron length between large-tissue/organ-specific genes and small-tissue/organ-specific genes with similar expression levels. Qualitative estimation shows that the deleterious effect (that is, the energetic burden of long introns in highly expressed genes is too negligible to be efficiently selected against in mammals. Conclusion The short introns in highly expressed genes should not be attributed to energy constraint. We evaluated evidence for the time cost hypothesis and other alternatives.

  2. High-efficiency and low-cost permanent magnet guideway consideration for high-Tc superconducting Maglev vehicle practical application

    International Nuclear Information System (INIS)

    Deng, Z; Wang, J; Zheng, J; Jing, H; Lu, Y; Ma, G; Liu, L; Liu, W; Zhang, Y; Wang, S

    2008-01-01

    In order to improve the cost performance of the present high-T c superconducting (HTS) Maglev vehicle system for practical application, the multi-pole permanent magnet guideway (PMG) concept was introduced. A well-known double-pole Halbach PMG was chosen as a representative of multi-pole PMGs to compare with traditional monopole PMGs from the point of view of levitation efficiency and cost. Experimental results show that YBCO bulks above the double-pole Halbach PMG can exhibit better load capability and guidance performance as well as dynamics stability at the applied working height between the bulk HTSC and the PMG due to a more reasonable magnetic field distribution at the working range of bulk HTSC. Furthermore, the double-pole PMG configuration can play a more important role in improving guidance performance due to the potential-well field configuration. By comparing with former 'century' PMGs, the double-pole Halbach PMG shows another remarkable advantage in reducing the cost of levitation. As another necessary issue, magnetic field homogeneity and the corresponding magnetic drag force of a double-pole Halbach PMG has been considered by experiment in spite of the above highlights. Synthetically, the multi-pole Halbach PMG design is concluded to be one important choice for future HTS Maglev vehicle applications because of its high efficiency and low cost.

  3. Establishing a Cost Basis for Converting the High Flux Isotope Reactor from High Enriched to Low Enriched Uranium Fuel

    International Nuclear Information System (INIS)

    Primm, Trent; Guida, Tracey

    2010-01-01

    Under the auspices of the Global Threat Reduction Initiative Reduced Enrichment for Research and Test Reactors Program, the National Nuclear Security Administration/Department of Energy (NNSA/DOE) has, as a goal, to convert research reactors worldwide from weapons grade to non-weapons grade uranium. The High Flux Isotope Reactor (HFIR) at Oak Ridge National Lab (ORNL) is one of the candidates for conversion of fuel from high enriched uranium (HEU) to low enriched uranium (LEU). A well documented business model, including tasks, costs, and schedules was developed to plan the conversion of HFIR. Using Microsoft Project, a detailed outline of the conversion program was established and consists of LEU fuel design activities, a fresh fuel shipping cask, improvements to the HFIR reactor building, and spent fuel operations. Current-value costs total $76 million dollars, include over 100 subtasks, and will take over 10 years to complete. The model and schedule follows the path of the fuel from receipt from fuel fabricator to delivery to spent fuel storage and illustrates the duration, start, and completion dates of each subtask to be completed. Assumptions that form the basis of the cost estimate have significant impact on cost and schedule.

  4. Between Cost Cheap Prices And Increasing High Quality Educational University In Pekanbaru City

    Directory of Open Access Journals (Sweden)

    Prama Widayat

    2018-02-01

    Full Text Available The need of higher education in the community has become the main thing for the future, not all can study at State Universities (PTN but some must enter in Private Universities (PTS. But the problem that arises is the problem of tuition fees in the PTS course higher than the state university, the tendency of prospective students in choosing Higher Education (PT based on cost and quality. While the problems from the PT side lies in the budget constraints in improving quality because of talk about the quality of course comprehensive from the means of lectures to the specialization of universities. Limitations of costs can at least be overcome by the synergy of universities, private companies and governments so it is not always student.

  5. Cost reduction for large turbine generator Pedestal in high seismic zone

    International Nuclear Information System (INIS)

    Sawhney, P.S.; Irani, P.; Pusheck, B.N.

    1985-01-01

    Turbine Generator Pedestals have generally been designed using reinforced concrete. For present day large turbine generators (1100 MWe class and above) with tall (about 80 feet) pedestals, the amount of reinforcing steel becomes quite large, especially for plants in high seismic zones. With the prime objective of cost reduction, an approach using steel/concrete composite design has been studied for a large BWR Turbine Generator pedestal with 0.3g peak ground acceleration. Large prefabricated steel modules were adopted for composite design and simplified construction. Design was based on the ACI and AISC codes. Costs and schedules were developed and compared with those for a conventionally designed reinforced concrete pedestal. Composite design was found to give considerable cost and schedule advantage over the conventional reinforced concrete design

  6. Effect of canister size on costs of disposal of SRP high-level wastes

    International Nuclear Information System (INIS)

    McDonell, W.R.

    1982-01-01

    The current plan for managing the high-level nuclear wastes at the Savannah River Plant (SRP) calls for processing them into solid forms contained in stainless steel canisters for eventual disposal in a federal geologic repository. A new SRP facility called the Defense Waste Processing Facility (DWPF) is being designed for the onsite waste processing operations. Preliminary evaluations indicate that costs of the overall disposal operation will depend significantly on the size of the canisters, which determines the number of waste forms to be processed. The objective of this study was to evaluate the effects of canister size on costs of DWPF process operations, including canister procurement, waste solidification, and interim storage, on offsite transport, and on repository costs of disposal, including provision of suitable waste packages

  7. A low-cost, high-resolution, video-rate imaging optical radar

    Energy Technology Data Exchange (ETDEWEB)

    Sackos, J.T.; Nellums, R.O.; Lebien, S.M.; Diegert, C.F. [Sandia National Labs., Albuquerque, NM (United States); Grantham, J.W.; Monson, T. [Air Force Research Lab., Eglin AFB, FL (United States)

    1998-04-01

    Sandia National Laboratories has developed a unique type of portable low-cost range imaging optical radar (laser radar or LADAR). This innovative sensor is comprised of an active floodlight scene illuminator and an image intensified CCD camera receiver. It is a solid-state device (no moving parts) that offers significant size, performance, reliability, and simplicity advantages over other types of 3-D imaging sensors. This unique flash LADAR is based on low cost, commercially available hardware, and is well suited for many government and commercial uses. This paper presents an update of Sandia`s development of the Scannerless Range Imager technology and applications, and discusses the progress that has been made in evolving the sensor into a compact, low, cost, high-resolution, video rate Laser Dynamic Range Imager.

  8. [Predicting individual risk of high healthcare cost to identify complex chronic patients].

    Science.gov (United States)

    Coderch, Jordi; Sánchez-Pérez, Inma; Ibern, Pere; Carreras, Marc; Pérez-Berruezo, Xavier; Inoriza, José M

    2014-01-01

    To develop a predictive model for the risk of high consumption of healthcare resources, and assess the ability of the model to identify complex chronic patients. A cross-sectional study was performed within a healthcare management organization by using individual data from 2 consecutive years (88,795 people). The dependent variable consisted of healthcare costs above the 95th percentile (P95), including all services provided by the organization and pharmaceutical consumption outside of the institution. The predictive variables were age, sex, morbidity-based on clinical risk groups (CRG)-and selected data from previous utilization (use of hospitalization, use of high-cost drugs in ambulatory care, pharmaceutical expenditure). A univariate descriptive analysis was performed. We constructed a logistic regression model with a 95% confidence level and analyzed sensitivity, specificity, positive predictive values (PPV), and the area under the ROC curve (AUC). Individuals incurring costs >P95 accumulated 44% of total healthcare costs and were concentrated in ACRG3 (aggregated CRG level 3) categories related to multiple chronic diseases. All variables were statistically significant except for sex. The model had a sensitivity of 48.4% (CI: 46.9%-49.8%), specificity of 97.2% (CI: 97.0%-97.3%), PPV of 46.5% (CI: 45.0%-47.9%), and an AUC of 0.897 (CI: 0.892 to 0.902). High consumption of healthcare resources is associated with complex chronic morbidity. A model based on age, morbidity, and prior utilization is able to predict high-cost risk and identify a target population requiring proactive care. Copyright © 2013 SESPAS. Published by Elsevier Espana. All rights reserved.

  9. Collapse Scenarios of High-Rise Buildings Using Plastic Limit Analysis

    Directory of Open Access Journals (Sweden)

    G. Liu

    2009-01-01

    Full Text Available The Twin Towers of the World Trade Center (WTC in New York, USA collapsed on 11 September, 2001. The incident is regarded as the most severe disaster for high-rise buildings in history. Investigations into the collapse scenarios are still being conducted. Possible collapse scenarios assessed by local and international experts were reported. Another possible collapse scenario of the WTC based on two hypotheses was proposed in this paper, and the idea of plastic limit analysis was applied to evaluate the approximate limit load. According to the theory analysis and numerical calculations, a conclusion can be drawn that the large fires, aroused by the terrorist attack, play a significant role on the collapse of the WTC.

  10. Limits on diffuse fluxes of high energy extraterrestrial neutrinos with the AMANDA-B10 detector

    International Nuclear Information System (INIS)

    Ahrens, J.; Bai, X.; Barwick, S.W.; Bay, R.C.; Becka, T.; Becker, K.-H.; Bernardini, E.; Bertrand, D.; Binon, F.; Boeser, S.; Botner, O.; Bouchta, A.; Bouhali, O.; Burgess, T.; Carius, S.; Castermans, T.; Chirkin, D.; Conrad, J.; Cooley, J.; Cowen, D.F.; Davour, A.; De Clercq, C.; DeYoung, T.; Desiati, P.; Doksus, P.; Ekstrom, P.; Feser, T.; Gaisser, T.K.; Ganugapati, R.; Gaug, M.; Geenen, H.; Gerhardt, L.; Goldschmidt, A.; Hallgren, A.; Halzen, F.; Hanson, K.; Hardtke, R.; Hauschildt, T.; Hellwig, M.; Herquet, P.; Hill, G.C.; Hulth, P.O.; Hughey, B.; Hultqvist, K.; Hundertmark, S.; Jacobsen, J.; Karle, A.; Kuehn, K.; Kim, J.; Kopke, L.; Kowalski, M.; Lamoureux, J.I.; Leich, H.; Leuthold, M.; Lindahl, P.; Liubarsky, I.; Madsen, J.; Mandli, K.; Marciniewski, P.; Matis, H.S.; McParland, C.P.; Messarius, T.; Miller, T.C.; Minaeva, Y.; Miocinovic, P.; Mock, P.C.; Morse, R.; Neunhoffer, T.; Niessen, P.; Nygren, D.R.; Ogelman, H.; Olbrechts, P.; Perez de los Heros, C.; Pohl, A.C.; Porrata, R.; Price, P.B.; Przybylski, G.T.; Rawlins, K.; Resconi, E.; Rhode, W.; Ribordy, M.; Richter, S.; Rodriguez Martino, J.; Romenesko, P.; Ross, D.; Sander, H.-G.; Schlenstedt, S.; Schinarakis, K.; Schmidt, T.; Schneider, D.; Schwarz, R.; Silvestri, A.; Solarz, M.; Stamatikos, M.; Spiczak, G.M.; Spiering, C.; Steele, D.; Steffen, P.; Stokstad, R.G.; Sulanke, K.-H.; Taboada, I.; Tilav, S.; Wagner, W.; Walck, C.; Wang, Y.-R.; Wiebusch, C.H.; Wiedemann, C.; Wischnewski, R.; Wissing, H.; Woschnagg, K.; Wu, W.; Yodh, G.; Young, S.

    2003-01-01

    Data from the AMANDA-B10 detector taken during the austral winter of 1997 have been searched for a diffuse flux of high energy extraterrestrial muon-neutrinos, as predicted from, e.g., the sum of all active galaxies in the universe. This search yielded no excess events above those expected from the background atmospheric neutrinos, leading to upper limits on the extraterrestrial neutrino flux. For an assumed E -2 spectrum, a 90 percent classical confidence level upper limit has been placed at a level E 2 Phi(E) = 8.4 x 10 -7 GeV cm -2 s -1 1 sr -1 (for a predominant neutrino energy range 6-1000 TeV) which is the most restrictive bound placed by any neutrino detector. When specific predicted spectral forms are considered, it is found that some are excluded

  11. Influence of laser cutting on the fatigue limit of two high strength steels

    International Nuclear Information System (INIS)

    Mateo, Antonio; Fargas, Gemma; Calvo, Jessica; Roa, Joan Josep

    2015-01-01

    Laser cutting is widely used in the metal industry, particularly when components of high strength steel sheets are produced. However, the roughness of cut edges produced by laser differs from that obtained by other methods, such as mechanical blanking, and this fact influences the fatigue performance. In the present investigation, specimens of two grades of high strength austenitic steels, i.e. AISI 301LN and TWIP17Mn, were cut by laser and tested in the high cycle fatigue regime to determine their corresponding fatigue limits. A series of fatigue specimens were tested without polishing and other series after a careful polishing of the cut edges, in order to assess the influence of the cut edges condition. Results indicate a significant influence of the edge roughness, more distinctive for AISI 301LN than for TWIP steel.

  12. Influence of laser cutting on the fatigue limit of two high strength steels

    Energy Technology Data Exchange (ETDEWEB)

    Mateo, Antonio; Fargas, Gemma; Calvo, Jessica; Roa, Joan Josep [Univ. Politecnica de Catalunya, Barcelona (Spain). Dept. of Materials Science and Metallurgical Engineering

    2015-02-01

    Laser cutting is widely used in the metal industry, particularly when components of high strength steel sheets are produced. However, the roughness of cut edges produced by laser differs from that obtained by other methods, such as mechanical blanking, and this fact influences the fatigue performance. In the present investigation, specimens of two grades of high strength austenitic steels, i.e. AISI 301LN and TWIP17Mn, were cut by laser and tested in the high cycle fatigue regime to determine their corresponding fatigue limits. A series of fatigue specimens were tested without polishing and other series after a careful polishing of the cut edges, in order to assess the influence of the cut edges condition. Results indicate a significant influence of the edge roughness, more distinctive for AISI 301LN than for TWIP steel.

  13. At-wavelength interferometry of high-NA diffraction-limited EUV optics

    Energy Technology Data Exchange (ETDEWEB)

    Goldberg, Kenneth A.; Naulleau, Patrick; Rekawa, Senajith; Denham, Paul; Liddle, J. Alexander; Anderson, Erik; Jackson, Keith; Bokor, Jeffrey; Attwood, David

    2003-08-01

    Recent advances in all-reflective diffraction-limited optical systems designed for extreme ultraviolet (EUV) lithography have pushed numerical aperture (NA) values from 0.1 to 0.3, providing Rayleigh resolutions of 27-nm. Worldwide, several high-NA EUV optics are being deployed to serve in the development of advanced lithographic techniques required for EUV lithography, including the creation and testing of new, high-resolution photoresists. One such system is installed on an undulator beamline at Lawrence Berkeley National Laboratory's Advanced Light Source. Sub{angstrom}-accuracy optical testing and alignment techniques, developed for use with the previous generations of EUV lithographic optical systems, are being extended for use at high NA. Considerations for interferometer design and use are discussed.

  14. At-wavelength interferometry of high-NA diffraction-limited EUV optics

    International Nuclear Information System (INIS)

    Goldberg, Kenneth A.; Naulleau, Patrick; Rekawa, Senajith; Denham, Paul; Liddle, J. Alexander; Anderson, Erik; Jackson, Keith; Bokor, Jeffrey; Attwood, David

    2003-01-01

    Recent advances in all-reflective diffraction-limited optical systems designed for extreme ultraviolet (EUV) lithography have pushed numerical aperture (NA) values from 0.1 to 0.3, providing Rayleigh resolutions of 27-nm. Worldwide, several high-NA EUV optics are being deployed to serve in the development of advanced lithographic techniques required for EUV lithography, including the creation and testing of new, high-resolution photoresists. One such system is installed on an undulator beamline at Lawrence Berkeley National Laboratory's Advanced Light Source. Sub(angstrom)-accuracy optical testing and alignment techniques, developed for use with the previous generations of EUV lithographic optical systems, are being extended for use at high NA. Considerations for interferometer design and use are discussed

  15. Quantity Surveying Undergraduates’ Awareness on Cost Significant of High-Rise Condominium Projects in Malaysia: The Case of a Private University in Malaysia

    OpenAIRE

    Peng Lee Wah; Seng Ng See; Choon Toh Tien; Sim Lim Cheng; Khian Yong Ching; Chen Goh Kai

    2016-01-01

    Recent developments in quantity surveying (QS) emphasised the importance of identifying cost significant elements (CSE). The knowledge on CSE of high-rise condominium projects (HRCP) is essential as high-rise residential multi-unit projects are the next option in building construction due to limited land areas in urban areas. This study aims to determine the levels of awareness among QS undergraduates of a private university in Malaysia on CSE of HRCP in Malaysia. The respondents’ knowledge o...

  16. Low Cost Al-Si Casting Alloy As In-Situ Composite for High Temperature Applications

    Science.gov (United States)

    Lee, Jonathan A.

    2000-01-01

    A new aluminum-silicon (Al-Si) alloy has been successfully developed at NASA- Marshall Space Flight Center (MSFC) that has significant improvement in tensile and fatigue strength at elevated temperatures (500 F-700 F). The alloy offers a number of benefits such as light weight, high hardness, low thermal expansion and high surface wear resistance. In hypereutectic form, this alloy is considered as an in-situ Al-Si composite with tensile strength of about 90% higher than the auto industry 390 alloy at 600 F. This composite is very economically produced by using either conventional permanent steel molds or die casting. The projected material cost is less than $0.90 per pound, and automotive components such as pistons can be cast for high production rate using conventional casting techniques with a low and fully accounted cost. Key Words: Metal matrix composites, In-situ composite, aluminum-silicon alloy, hypereutectic alloy, permanent mold casting, die casting.

  17. The high intensity solar cell - Key to low cost photovoltaic power

    Science.gov (United States)

    Sater, B. L.; Goradia, C.

    1975-01-01

    This paper discusses the problems associated with conventional solar cells at high intensities and presents the design considerations and performance characteristics of the 'high intensity' (HI) solar cell which appears to eliminate the major problems. Test data obtained at greater than 250 AM1 suns gave a peak output power density of 2 W per sq cm at an efficiency exceeding 6% with an unoptimized cell operating at over 100 C. It appears that operation at 1000 AM1 suns at efficiencies greater than 10% is possible. At 1000 AM1 suns and 10% efficiency, the HI cell manufacturing cost is estimated to be $0.25/watt, with multi-megawatt annual production capability already existing within the industrial sector. A high intensity solar system was also analyzed to determine its cost effectiveness and to assess the benefits of further improving HI cell efficiency.

  18. Inefficient national environmental regulation as a signal of high abatement costs

    Energy Technology Data Exchange (ETDEWEB)

    Steiner, U.

    1997-12-31

    This paper analyses the importance of informational asymmetries in international environmental regulation by use of a game theoretic approach of signaling games. More specific it analysis whether it is possible for a government to try to extract higher compensation in an international unidirectoral environmental problem. This may be possible when the national environmental regulation carries a signal of the cost of the regulated industry. In this case the government e.g. by means of inefficient environmental regulation on a national level may try to signal high abatement costs. In spite of the fact that many international environmental problems seem to be solvable by the use of financial payments there are only few examples that compensation payment arrangements have been implemented. As many countries and especially many polluting firms possess better information about abatement costs than the countries that receive the pollution, it is worthwhile to include asymmetric information. Consequently, this paper analyses whether the introduction of asymmetric information about abatement costs may bring forward incentives to misrepresent the true abatement cost in order to capture more compensation. If these incentives turn out to be present, it may explain some of the suspicion against using financial payment in order to induce other countries to join an agreement. The analysis shows that it may indeed be the case that the expected gain from cheating is so large that it gives incentives to use an inefficient national environmental policy. (au) 13 refs.

  19. Development and evaluation of a low-cost and high-capacity DICOM image data storage system for research.

    Science.gov (United States)

    Yakami, Masahiro; Ishizu, Koichi; Kubo, Takeshi; Okada, Tomohisa; Togashi, Kaori

    2011-04-01

    Thin-slice CT data, useful for clinical diagnosis and research, is now widely available but is typically discarded in many institutions, after a short period of time due to data storage capacity limitations. We designed and built a low-cost high-capacity Digital Imaging and COmmunication in Medicine (DICOM) storage system able to store thin-slice image data for years, using off-the-shelf consumer hardware components, such as a Macintosh computer, a Windows PC, and network-attached storage units. "Ordinary" hierarchical file systems, instead of a centralized data management system such as relational database, were adopted to manage patient DICOM files by arranging them in directories enabling quick and easy access to the DICOM files of each study by following the directory trees with Windows Explorer via study date and patient ID. Software used for this system was open-source OsiriX and additional programs we developed ourselves, both of which were freely available via the Internet. The initial cost of this system was about $3,600 with an incremental storage cost of about $900 per 1 terabyte (TB). This system has been running since 7th Feb 2008 with the data stored increasing at the rate of about 1.3 TB per month. Total data stored was 21.3 TB on 23rd June 2009. The maintenance workload was found to be about 30 to 60 min once every 2 weeks. In conclusion, this newly developed DICOM storage system is useful for research due to its cost-effectiveness, enormous capacity, high scalability, sufficient reliability, and easy data access.

  20. High level waste transport and disposal cost calculations for the United Kingdom

    International Nuclear Information System (INIS)

    Nattress, P.C.; Ward, R.D.

    1992-01-01

    Commercial nuclear power has been generated in the United Kingdom since 1962, and throughout that time fuel has been reprocessed giving rise to high level waste. This has been managed by storing fission products and related wastes as highly active liquor, and more recently by a program of vitrification and storage of the glass blocks produced. Government policy is that vitrified high level waste should be stored for at least 50 years, which has the technical advantage of allowing the heat output rate of the waste to fall, making disposal easier and cheaper. Thus, there is no immediate requirement to develop a deep geological repository in the UK, but the nuclear companies do have a requirement to make financial provision out of current revenues for high level waste disposal at a future repository. In 1991 the interested organizations undertook a new calculation of costs for such provisions, which is described here. The preliminary work for the calculation included the assumption of host geology characteristics, a compatible repository concept including overpacking, and a range of possible nuclear programs. These have differing numbers of power plants, and differing mixes of high level waste from reprocessing and spent fuel for direct disposal. An algorithm was then developed so that the cost of high level waste disposal could be calculated for any required case within a stated envelope of parameters. An Example Case was then considered in detail leading to the conclusion that a repository to meet the needs of a constant UK nuclear economy up to the middle of the next century would have a cash cost of UK Pounds 1194M (US$2011M). By simple division the cost to a kWh of electricity is UK Pounds 0.00027 (0.45 US mil). (author)

  1. Mobility at any cost? Necessity and limits. Part 2; Mobilitaet um jeden Preis? Notwendigkeit und Grenzen. T. 2

    Energy Technology Data Exchange (ETDEWEB)

    Haury, H J; Assmann, G; Froese, B; Jahn, T [comps.

    1996-08-01

    Mobility and progress have caused depletion of resources, air pollution, noise and stress resulting from increasing traffic. Ecological and health effects impose limits on mobility. Solutions are offered by intelligent traffic concepts (task sharing between transportation systems, logistics and telecommunication, sustainable mobility, environment-friendly transportation systems and measures for traffic reduction) and, best of all, by preventing traffic. This, however, necessitates a new concept of mobility. (GL) [Deutsch] Mobilitaet und Fortschritt fuehren in die Sackgasse: Resourcenverbrauch, Luftverschmutzung, Laerm und Stress erfolgen durch wachsendes Verkehrsaufkommen. Oekologische Folgen und gesundheitliche Auswirkungen setzen dem Mobilitaetsbeduerfnis deutliche Grenzen. Loesungsansaetze fuer umwelt- und gesundheitsvertraegliche Verkehrsentwicklung sind intelligente Verkehrskonzepte (Aufgabenverteilung zwischen den Verkehrsmitteln, Logistik und Telekommunikation, sustainable Mobility, Einsatz umweltfreundlicher Verkehrsmittel und umweltbezogene Massnahmen zur Verkehrsreduktion) und als wichtigste Groesse die Verkehrsvermeidung. Dafuer bedarf es in unserer Gesellschaft ein neues Verstaendnis von Mobilitaet.(GL)

  2. Cost Analysis of a High Support Housing Initiative for Persons with Severe Mental Illness and Long-Term Psychiatric Hospitalization.

    Science.gov (United States)

    Rudoler, David; de Oliveira, Claire; Jacob, Binu; Hopkins, Melonie; Kurdyak, Paul

    2018-01-01

    The objective of this article was to conduct a cost analysis comparing the costs of a supportive housing intervention to inpatient care for clients with severe mental illness who were designated alternative-level care while inpatient at the Centre for Addiction and Mental Health in Toronto. The intervention, called the High Support Housing Initiative, was implemented in 2013 through a collaboration between 15 agencies in the Toronto area. The perspective of this cost analysis was that of the Ontario Ministry of Health and Long-Term Care. We compared the cost of inpatient mental health care to high-support housing. Cost data were derived from a variety of sources, including health administrative data, expenditures reported by housing providers, and document analysis. The High Support Housing Initiative was cost saving relative to inpatient care. The average cost savings per diem were between $140 and $160. This amounts to an annual cost savings of approximately $51,000 to $58,000. When tested through sensitivity analysis, the intervention remained cost saving in most scenarios; however, the result was highly sensitive to health system costs for clients of the High Support Housing Initiative program. This study suggests the High Support Housing Initiative is potentially cost saving relative to inpatient hospitalization at the Centre for Addiction and Mental Health.

  3. U.S. DOE Progress Towards Developing Low-Cost, High Performance, Durable Polymer Electrolyte Membranes for Fuel Cell Applications.

    Science.gov (United States)

    Houchins, Cassidy; Kleen, Greg J; Spendelow, Jacob S; Kopasz, John; Peterson, David; Garland, Nancy L; Ho, Donna Lee; Marcinkoski, Jason; Martin, Kathi Epping; Tyler, Reginald; Papageorgopoulos, Dimitrios C

    2012-12-18

    Low cost, durable, and selective membranes with high ionic conductivity are a priority need for wide-spread adoption of polymer electrolyte membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs). Electrolyte membranes are a major cost component of PEMFC stacks at low production volumes. PEMFC membranes also impose limitations on fuel cell system operating conditions that add system complexity and cost. Reactant gas and fuel permeation through the membrane leads to decreased fuel cell performance, loss of efficiency, and reduced durability in both PEMFCs and DMFCs. To address these challenges, the U.S. Department of Energy (DOE) Fuel Cell Technologies Program, in the Office of Energy Efficiency and Renewable Energy, supports research and development aimed at improving ion exchange membranes for fuel cells. For PEMFCs, efforts are primarily focused on developing materials for higher temperature operation (up to 120 °C) in automotive applications. For DMFCs, efforts are focused on developing membranes with reduced methanol permeability. In this paper, the recently revised DOE membrane targets, strategies, and highlights of DOE-funded projects to develop new, inexpensive membranes that have good performance in hot and dry conditions (PEMFC) and that reduce methanol crossover (DMFC) will be discussed.

  4. U.S. DOE Progress Towards Developing Low-Cost, High Performance, Durable Polymer Electrolyte Membranes for Fuel Cell Applications

    Directory of Open Access Journals (Sweden)

    Dimitrios C. Papageorgopoulos

    2012-12-01

    Full Text Available Low cost, durable, and selective membranes with high ionic conductivity are a priority need for wide-spread adoption of polymer electrolyte membrane fuel cells (PEMFCs and direct methanol fuel cells (DMFCs. Electrolyte membranes are a major cost component of PEMFC stacks at low production volumes. PEMFC membranes also impose limitations on fuel cell system operating conditions that add system complexity and cost. Reactant gas and fuel permeation through the membrane leads to decreased fuel cell performance, loss of efficiency, and reduced durability in both PEMFCs and DMFCs. To address these challenges, the U.S. Department of Energy (DOE Fuel Cell Technologies Program, in the Office of Energy Efficiency and Renewable Energy, supports research and development aimed at improving ion exchange membranes for fuel cells. For PEMFCs, efforts are primarily focused on developing materials for higher temperature operation (up to 120 °C in automotive applications. For DMFCs, efforts are focused on developing membranes with reduced methanol permeability. In this paper, the recently revised DOE membrane targets, strategies, and highlights of DOE-funded projects to develop new, inexpensive membranes that have good performance in hot and dry conditions (PEMFC and that reduce methanol crossover (DMFC will be discussed.

  5. Implicit high-order discontinuous Galerkin method with HWENO type limiters for steady viscous flow simulations

    Science.gov (United States)

    Jiang, Zhen-Hua; Yan, Chao; Yu, Jian

    2013-08-01

    Two types of implicit algorithms have been improved for high order discontinuous Galerkin (DG) method to solve compressible Navier-Stokes (NS) equations on triangular grids. A block lower-upper symmetric Gauss-Seidel (BLU-SGS) approach is implemented as a nonlinear iterative scheme. And a modified LU-SGS (LLU-SGS) approach is suggested to reduce the memory requirements while retain the good convergence performance of the original LU-SGS approach. Both implicit schemes have the significant advantage that only the diagonal block matrix is stored. The resulting implicit high-order DG methods are applied, in combination with Hermite weighted essentially non-oscillatory (HWENO) limiters, to solve viscous flow problems. Numerical results demonstrate that the present implicit methods are able to achieve significant efficiency improvements over explicit counterparts and for viscous flows with shocks, and the HWENO limiters can be used to achieve the desired essentially non-oscillatory shock transition and the designed high-order accuracy simultaneously.

  6. Limits to the Fraction of High-energy Photon Emitting Gamma-Ray Bursts

    Science.gov (United States)

    Akerlof, Carl W.; Zheng, WeiKang

    2013-02-01

    After almost four years of operation, the two instruments on board the Fermi Gamma-ray Space Telescope have shown that the number of gamma-ray bursts (GRBs) with high-energy photon emission above 100 MeV cannot exceed roughly 9% of the total number of all such events, at least at the present detection limits. In a recent paper, we found that GRBs with photons detected in the Large Area Telescope have a surprisingly broad distribution with respect to the observed event photon number. Extrapolation of our empirical fit to numbers of photons below our previous detection limit suggests that the overall rate of such low flux events could be estimated by standard image co-adding techniques. In this case, we have taken advantage of the excellent angular resolution of the Swift mission to provide accurate reference points for 79 GRB events which have eluded any previous correlations with high-energy photons. We find a small but significant signal in the co-added field. Guided by the extrapolated power-law fit previously obtained for the number distribution of GRBs with higher fluxes, the data suggest that only a small fraction of GRBs are sources of high-energy photons.

  7. LIMITS TO THE FRACTION OF HIGH-ENERGY PHOTON EMITTING GAMMA-RAY BURSTS

    International Nuclear Information System (INIS)

    Akerlof, Carl W.; Zheng, WeiKang

    2013-01-01

    After almost four years of operation, the two instruments on board the Fermi Gamma-ray Space Telescope have shown that the number of gamma-ray bursts (GRBs) with high-energy photon emission above 100 MeV cannot exceed roughly 9% of the total number of all such events, at least at the present detection limits. In a recent paper, we found that GRBs with photons detected in the Large Area Telescope have a surprisingly broad distribution with respect to the observed event photon number. Extrapolation of our empirical fit to numbers of photons below our previous detection limit suggests that the overall rate of such low flux events could be estimated by standard image co-adding techniques. In this case, we have taken advantage of the excellent angular resolution of the Swift mission to provide accurate reference points for 79 GRB events which have eluded any previous correlations with high-energy photons. We find a small but significant signal in the co-added field. Guided by the extrapolated power-law fit previously obtained for the number distribution of GRBs with higher fluxes, the data suggest that only a small fraction of GRBs are sources of high-energy photons.

  8. A Strong Limit on the Very-high-energy Emission from GRB 150323A

    Science.gov (United States)

    Abeysekara, A. U.; Archer, A.; Benbow, W.; Bird, R.; Brose, R.; Buchovecky, M.; Bugaev, V.; Connolly, M. P.; Cui, W.; Errando, M.; Falcone, A.; Feng, Q.; Finley, J. P.; Flinders, A.; Fortson, L.; Furniss, A.; Gillanders, G. H.; Hütten, M.; Hanna, D.; Hervet, O.; Holder, J.; Hughes, G.; Humensky, T. B.; Johnson, C. A.; Kaaret, P.; Kar, P.; Kelley-Hoskins, N.; Kertzman, M.; Kieda, D.; Krause, M.; Krennrich, F.; Lang, M. J.; Lin, T. T. Y.; Maier, G.; McArthur, S.; Moriarty, P.; Mukherjee, R.; O’Brien, S.; Ong, R. A.; Park, N.; Perkins, J. S.; Petrashyk, A.; Pohl, M.; Popkow, A.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Richards, G. T.; Roache, E.; Rulten, C.; Sadeh, I.; Santander, M.; Sembroski, G. H.; Shahinyan, K.; Tyler, J.; Wakely, S. P.; Weiner, O. M.; Weinstein, A.; Wells, R. M.; Wilcox, P.; Wilhelm, A.; Williams, D. A.; Zitzer, B.; VERITAS Collaboration; Vurm, Indrek; Beloborodov, Andrei

    2018-04-01

    On 2015 March 23, the Very Energetic Radiation Imaging Telescope Array System (VERITAS) responded to a Swift-Burst Alert Telescope (BAT) detection of a gamma-ray burst, with observations beginning 270 s after the onset of BAT emission, and only 135 s after the main BAT emission peak. No statistically significant signal is detected above 140 GeV. The VERITAS upper limit on the fluence in a 40-minute integration corresponds to about 1% of the prompt fluence. Our limit is particularly significant because the very-high-energy (VHE) observation started only ∼2 minutes after the prompt emission peaked, and Fermi-Large Area Telescope observations of numerous other bursts have revealed that the high-energy emission is typically delayed relative to the prompt radiation and lasts significantly longer. Also, the proximity of GRB 150323A (z = 0.593) limits the attenuation by the extragalactic background light to ∼50% at 100–200 GeV. We conclude that GRB 150323A had an intrinsically very weak high-energy afterglow, or that the GeV spectrum had a turnover below ∼100 GeV. If the GRB exploded into the stellar wind of a massive progenitor, the VHE non-detection constrains the wind density parameter to be A ≳ 3 × 1011 g cm‑1, consistent with a standard Wolf–Rayet progenitor. Alternatively, the VHE emission from the blast wave would be weak in a very tenuous medium such as the interstellar medium, which therefore cannot be ruled out as the environment of GRB 150323A.

  9. Long-dated evaluation of the external costs of the nuclear; L'evaluation des couts externes a long terme de la filiere nucleaire: interets et limites

    Energy Technology Data Exchange (ETDEWEB)

    Le Dars, A.; Schneider, T

    2002-09-01

    Since the middle of the years 1990, the European Commission developed an ''ExternE'' methodology to propose an homogenous evaluation of the sanitary and environmental external costs of the various energy sectors in Europe. This document discusses the taking into account of the long-dated and analyzes the interests and the limits of the monetary evaluation, in terms of external costs, of the nuclear choice. It is organized in three chapters: 1. a presentation and a discussion on the various evaluation of the ''ExternE'' methodology; 2. a description of the available methods for the monetary evaluation of the long-dated impacts and more particularly the analysis of the monetary values actualization principle; 3. highlighted of the impacts for which the monetary evaluations exist. (A.L.B.)

  10. Application of Low-Cost UASs and Digital Photogrammetry for High-Resolution Snow Depth Mapping in the Arctic

    Directory of Open Access Journals (Sweden)

    Emiliano Cimoli

    2017-11-01

    Full Text Available The repeat acquisition of high-resolution snow depth measurements has important research and civil applications in the Arctic. Currently the surveying methods for capturing the high spatial and temporal variability of the snowpack are expensive, in particular for small areal extents. An alternative methodology based on Unmanned Aerial Systems (UASs and digital photogrammetry was tested over varying surveying conditions in the Arctic employing two diverse and low-cost UAS-camera combinations (500 and 1700 USD, respectively. Six areas, two in Svalbard and four in Greenland, were mapped covering from 1386 to 38,410 m2. The sites presented diverse snow surface types, underlying topography and light conditions in order to test the method under potentially limiting conditions. The resulting snow depth maps achieved spatial resolutions between 0.06 and 0.09 m. The average difference between UAS-estimated and measured snow depth, checked with conventional snow probing, ranged from 0.015 to 0.16 m. The impact of image pre-processing was explored, improving point cloud density and accuracy for different image qualities and snow/light conditions. Our UAS photogrammetry results are expected to be scalable to larger areal extents. While further validation is needed, with the inclusion of extra validation points, the study showcases the potential of this cost-effective methodology for high-resolution monitoring of snow dynamics in the Arctic and beyond.

  11. Do "premium" joint implants add value?: analysis of high cost joint implants in a community registry.

    Science.gov (United States)

    Gioe, Terence J; Sharma, Amit; Tatman, Penny; Mehle, Susan

    2011-01-01

    Numerous joint implant options of varying cost are available to the surgeon, but it is unclear whether more costly implants add value in terms of function or longevity. We evaluated registry survival of higher-cost "premium" knee and hip components compared to lower-priced standard components. Premium TKA components were defined as mobile-bearing designs, high-flexion designs, oxidized-zirconium designs, those including moderately crosslinked polyethylene inserts, or some combination. Premium THAs included ceramic-on-ceramic, metal-on-metal, and ceramic-on-highly crosslinked polyethylene designs. We compared 3462 standard TKAs to 2806 premium TKAs and 868 standard THAs to 1311 premium THAs using standard statistical methods. The cost of the premium implants was on average approximately $1000 higher than the standard implants. There was no difference in the cumulative revision rate at 7-8 years between premium and standard TKAs or THAs. In this time frame, premium implants did not demonstrate better survival than standard implants. Revision indications for TKA did not differ, and infection and instability remained contributors. Longer followup is necessary to demonstrate whether premium implants add value in younger patient groups. Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

  12. The high exponent limit $p \\to \\infty$ for the one-dimensional nonlinear wave equation

    OpenAIRE

    Tao, Terence

    2009-01-01

    We investigate the behaviour of solutions $\\phi = \\phi^{(p)}$ to the one-dimensional nonlinear wave equation $-\\phi_{tt} + \\phi_{xx} = -|\\phi|^{p-1} \\phi$ with initial data $\\phi(0,x) = \\phi_0(x)$, $\\phi_t(0,x) = \\phi_1(x)$, in the high exponent limit $p \\to \\infty$ (holding $\\phi_0, \\phi_1$ fixed). We show that if the initial data $\\phi_0, \\phi_1$ are smooth with $\\phi_0$ taking values in $(-1,1)$ and obey a mild non-degeneracy condition, then $\\phi$ converges locally uniformly to a piecewis...

  13. Focusing of high power ultrasound beams and limiting values of shock wave parameters

    Science.gov (United States)

    Bessonova, O. V.; Khokhlova, V. A.; Bailey, M. R.; Canney, M. S.; Crum, L. A.

    2009-10-01

    In this work, the influence of nonlinear and diffraction effects on amplification factors of focused ultrasound systems is investigated. The limiting values of acoustic field parameters obtained by focusing of high power ultrasound are studied. The Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation was used for the numerical modeling. Solutions for the nonlinear acoustic field were obtained at output levels corresponding to both pre- and post-shock formation conditions in the focal area of the beam in a weakly dissipative medium. Numerical solutions were compared with experimental data as well as with known analytic predictions.

  14. Gender Identification Using High-Frequency Speech Energy: Effects of Increasing the Low-Frequency Limit.

    Science.gov (United States)

    Donai, Jeremy J; Halbritter, Rachel M

    The purpose of this study was to investigate the ability of normal-hearing listeners to use high-frequency energy for gender identification from naturally produced speech signals. Two experiments were conducted using a repeated-measures design. Experiment 1 investigated the effects of increasing high-pass filter cutoff (i.e., increasing the low-frequency spectral limit) on gender identification from naturally produced vowel segments. Experiment 2 studied the effects of increasing high-pass filter cutoff on gender identification from naturally produced sentences. Confidence ratings for the gender identification task were also obtained for both experiments. Listeners in experiment 1 were capable of extracting talker gender information at levels significantly above chance from vowel segments high-pass filtered up to 8.5 kHz. Listeners in experiment 2 also performed above chance on the gender identification task from sentences high-pass filtered up to 12 kHz. Cumulatively, the results of both experiments provide evidence that normal-hearing listeners can utilize information from the very high-frequency region (above 4 to 5 kHz) of the speech signal for talker gender identification. These findings are at variance with current assumptions regarding the perceptual information regarding talker gender within this frequency region. The current results also corroborate and extend previous studies of the use of high-frequency speech energy for perceptual tasks. These findings have potential implications for the study of information contained within the high-frequency region of the speech spectrum and the role this region may play in navigating the auditory scene, particularly when the low-frequency portion of the spectrum is masked by environmental noise sources or for listeners with substantial hearing loss in the low-frequency region and better hearing sensitivity in the high-frequency region (i.e., reverse slope hearing loss).

  15. Limiting stable states of high-Tc superconductors in the alternating current modes

    International Nuclear Information System (INIS)

    Romanovskii, V.R.; Watanabe, K.; Awaji, S.

    2014-01-01

    The limiting current-carrying capacity of high-T c superconductor and superconducting tape has been studied in the alternating current states. The features that are responsible for their stable formation have been investigated under the conduction-cooled conditions when the operating peak values of the electric field and the current may essentially exceed the corresponding critical values of superconductor. Besides, it has been proved that these peak values are higher than the values of the electric field and the current, which lead to the thermal runaway phenomenon when the current instability onset occurs in the operating modes with direct current. As a result, the stable extremely high heat generation exists in these operating states, which can be called as overloaded states. The limiting stable peak values of charged currents and stability conditions have been determined taking into account the flux creep states of superconductors. The analysis performed has revealed that there exist characteristic times defining the corresponding time windows in the stable development of overloaded states of the alternating current. In order to explain their existence, the basic thermo-electrodynamics mechanisms have been formulated, which have allowed to explain the high stable values of the temperature and the induced electric field before the onset of alternating current instability. In general, it has been shown that the high-T c superconductors may stably operate in the overloaded alternating current states even under the not intensive cooling conditions at a very high level of heat generation, which is not considered in the existing theory of losses. (authors)

  16. Advanced gasifier and water gas shift technologies for low cost coal conversion to high hydrogen syngas

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, Andrew Kramer [Gas Technology Inst., Des Plaines, IL (United States)

    2016-09-30

    The Gas Technology Institute (GTI) and team members RTI International (RTI), Coanda Research and Development, and Nexant, are developing and maturing a portfolio of technologies to meet the United States Department of Energy (DOE) goals for lowering the cost of producing high hydrogen syngas from coal for use in carbon capture power and coal-to-liquids/chemicals. This project matured an advanced pilot-scale gasifier, with scalable and commercially traceable components, to readiness for use in a first-of-a-kind commercially-relevant demonstration plant on the scale of 500-1,000 tons per day (TPD). This was accomplished through cold flow simulation of the gasifier quench zone transition region at Coanda and through an extensive hotfire gasifier test program on highly reactive coal and high ash/high ash fusion temperature coals at GTI. RTI matured an advanced water gas shift process and catalyst to readiness for testing at pilot plant scale through catalyst development and testing, and development of a preliminary design basis for a pilot scale reactor demonstrating the catalyst. A techno-economic analysis was performed by Nexant to assess the potential benefits of the gasifier and catalyst technologies in the context of power production and methanol production. This analysis showed an 18%reduction in cost of power and a 19%reduction in cost of methanol relative to DOE reference baseline cases.

  17. Effects of Birkeland current limitation on high-latitude convection patterns

    International Nuclear Information System (INIS)

    Marklund, G.T.; Raadu, M.A.; Lindqvist, P.-A.

    1984-12-01

    It is shown how the high-latitude convection pattern may be mo- dified by substorm-enhanced polarization electric fields. These are generated whenever the flow of those Birkeland currents which are associated with ionospheric conductivity gradients is limited. Such Birkeland currents are fed mainly by the enhanced Pedersen current in the evening and morning sectors of the auro- ral oval and by the enhanced Hall current around local midnight. As the current limitation increases, the ionospheric potential, represented here by a symmetric two-cell pattern, will rotate clockwise and deform, just as the associated Birkeland current distribution. The resulting patterns are shown to agree well with observations. A pronounced westward intrusion of the equi- potential contours occurs in the auroral oval, and may be asso- ciated with the Westward Travelling Surge. This feature does not however require any assumed longitudinal conductivity gradi- ents. Rather it falls out naturally when the limitation of the enhanced Pedersen current is taken into account. (Author)

  18. Ideal-MHD beta limits: scaling laws and comparison with Doublet III high-beta plasmas

    International Nuclear Information System (INIS)

    Bernard, L.C.; Bhadra, D.K.; Helton, F.J.; Lao, L.L.; Todd, T.N.

    1983-06-01

    Doublet III (DIII) recently has achieved a value for #betta#, the ratio of volume averaged plasma to magnetic pressure, of 4.5%. This #betta# value is in the range required for an economically attractive tokamak reactor, and also close to the relevant limit predicted by ideal-MHD theory. It is therefore of great interest to assess the validity of the theory by comparison with experiment and thus to have a basis for the prediction of future reactor performance. A large variety of plasma shapes have been obtained in DIII. These shapes can be divided into two classes: (1) limiter discharges, and (2) diverted discharges, which are of great interest because of their good confinement in the H-mode operation. We derive simple scaling laws from the variation of optimized ideal-MHD beta limits (#betta#/sub c/) with plasma shape parameters. The current profile is optimized for fixed plasma shapes, separately for the high-n (ballooning) and the low-n (kink) modes. Results are presented in the form of suitability normalized curves of #betta# versus poloidal beta, #betta#/sub p/, for both ballooning and kink modes in order to simultaneously compare all the DIII experimental data

  19. High-Speed Imaging of Explosive Droplet Boiling at the Superheat Limit

    Science.gov (United States)

    Ferris, F. Robert; Hermanson, Jim; Asadollahi, Arash; Esmaeeli, Asghar

    2017-11-01

    The explosive boiling processes of droplets of diethyl ether (1-2 mm in diameter) at the superheat limit were examined both experimentally and computationally. Experimentally, droplet explosion was studied using a heated bubble column to bring the test droplet to the superheat limit. The droplet fluid was diethyl ether (superheat limit 147 C at 1 bar) with immiscible glycerol employed as the heated host fluid. Tests were carried out at pressures between 0.5 and 4 bar absolute. The pressure rise associated with the explosive boiling event was captured using a piezoelectric quartz pressure transducer with a 1 MHz DAQ system. High-speed imaging of the interfacial behavior during explosive boiling was performed using a Phantom v12.1 camera at a frame rate of up to one million frames per second with the droplets illuminated by diffuse back-lighting. The imaging reveals features of the Rayleigh-Taylor instability at the vapor-liquid interface resulting from the unstable boiling process. Computationally, Direct Numerical Simulations are performed at Southern Illinois University Carbondale to compliment the experimental tests. NSF Award Number 1511152.

  20. Low-frequency-high-intensity limit of the Keldysh-Faisal-Reiss theory

    International Nuclear Information System (INIS)

    Bauer, Jaroslaw

    2006-01-01

    When a frequency of the circularly polarized laser field approaches zero the above threshold ionization rate should approach the well-known static-field limit of tunneling ionization. In the high-intensity limit of the laser field the Keldysh-Faisal-Reiss (KFR) theory is expected to be valid. For the ground state of a hydrogen atom we study various forms of the KFR theory when both conditions: ω<<1 a.u. and γ<<1 (ω is the frequency and γ the Keldysh parameter) are satisfied. For the circularly polarized laser field ionization rate in the Keldysh theory [which utilizes the length gauge (d(vector sign)·E(vector sign)) form of the matrix element] is calculated analytically. We show numerically that if the WKB Coulomb correction in the final state of the ionized electron is included, the Keldysh theory gives the correct result in the tunneling domain. In the barrier-suppression regime the Keldysh theory without this correction gives ionization rates close to the exact static-field results. The Reiss theory [which utilizes the velocity gauge (p(vector sign)·A(vector sign)) form of the matrix element] leads to too small ionization rates in the limit ω→0, γ→0

  1. Using cost-benefit analysis and social return on investment to evaluate the impact of social enterprise: Promises, implementation, and limitations.

    Science.gov (United States)

    Cordes, Joseph J

    2017-10-01

    Since the early 2000's there has been growing interest in using the Social Return on Investment (SROI) as a measure for assessing the performance of social enterprises. By analogy with its business counterpart, the Return on Investment (ROI), the SROI is a metric that compares the monetized social costs of a program with the monetized social benefits of achieving an outcome (or set of outcomes). For example, calculating the SROI of a nonprofit half-way house for drug addicts might involve estimating the reduced social costs attributable to successful rehabilitation of addicts, and comparing this to the social costs of operating the half-way house. Alternatively, the total return of a for-profit social enterprise providing affordable housing might consist both of the traditional private return on investment along with the economic value of meeting the housing needs of lower income households. Early descriptions of the methodology for calculating the SROI suggest that the approach initially evolved from standard methodologies found in the business finance literature for evaluating investments, with the important twist that nonprofit sector returns/payoffs are defined in broader social terms (Thornley, Anderson, & Dixon, 2016). Yet, someone who is familiar with the economic literature on cost benefit analysis (CBA) as it is applied to the evaluation of public programs cannot help but be struck by the similarity between the outcomes that CBA is intended to measure, and those that are the object of efforts to calculate the SROI. One implication is that the literature on the theory and practice of cost benefit analysis offers useful lessons about how to measure the social return on investment, as well as about potential caveats and limitations that need to be confronted when attempting to undertake an analysis of the SROI. The paper discusses the potential uses and limitations of CBA and SROI as tools that governments, private donor/investors, and foundations can use to

  2. Big data in health care: using analytics to identify and manage high-risk and high-cost patients.

    Science.gov (United States)

    Bates, David W; Saria, Suchi; Ohno-Machado, Lucila; Shah, Anand; Escobar, Gabriel

    2014-07-01

    The US health care system is rapidly adopting electronic health records, which will dramatically increase the quantity of clinical data that are available electronically. Simultaneously, rapid progress has been made in clinical analytics--techniques for analyzing large quantities of data and gleaning new insights from that analysis--which is part of what is known as big data. As a result, there are unprecedented opportunities to use big data to reduce the costs of health care in the United States. We present six use cases--that is, key examples--where some of the clearest opportunities exist to reduce costs through the use of big data: high-cost patients, readmissions, triage, decompensation (when a patient's condition worsens), adverse events, and treatment optimization for diseases affecting multiple organ systems. We discuss the types of insights that are likely to emerge from clinical analytics, the types of data needed to obtain such insights, and the infrastructure--analytics, algorithms, registries, assessment scores, monitoring devices, and so forth--that organizations will need to perform the necessary analyses and to implement changes that will improve care while reducing costs. Our findings have policy implications for regulatory oversight, ways to address privacy concerns, and the support of research on analytics. Project HOPE—The People-to-People Health Foundation, Inc.

  3. OPERATIONAL LIMITATIONS FOR DEMOLITION OF A HIGHLY ALPHA CONTAMINATED BUILDING MODLES VERSUS MEASURED AIR & SURFACE ACTIVITY CONCENTRATIONS

    Energy Technology Data Exchange (ETDEWEB)

    LLOYD, E.R.

    2006-11-02

    The demolition of a facility historically used for processing and handling transuranic materials is considered. Residual alpha emitting radionuclide contamination poses an exposure hazard if released to the local environment during the demolition. The process of planning for the demolition of this highly alpha contaminated building, 232-Z, included a predemolition modeling analysis of potential exposures. Estimated emission rates were used as input to an air dispersion model to estimate frequencies of occurrence of peak air and surface exposures. Postdemolition modeling was also conducted, based on the actual demolition schedule and conditions. The modeling results indicated that downwind deposition is the main operational limitation for demolition of a highly alpha-contaminated building. During the demolition of 232-Z, airborne radiation and surface contamination were monitored. The resultant non-detect monitoring results indicate a significant level of conservatism in the modeled results. This comparison supports the use of more realistic assumption in the estimating emission rates. The resultant reduction in modeled levels of potential exposures has significant implications in terms of the projected costs of demolition of such structures.

  4. Cost-Effectiveness of Highly Active Antiretroviral Therapy in South Africa.

    Directory of Open Access Journals (Sweden)

    2005-12-01

    Full Text Available BACKGROUND: Little information exists on the impact of highly active antiretroviral therapy (HAART on health-care provision in South Africa despite increasing scale-up of access to HAART and gradual reduction in HAART prices. METHODS AND FINDINGS: Use and cost of services for 265 HIV-infected adults without AIDS (World Health Organization [WHO] stage 1, 2, or 3 and 27 with AIDS (WHO stage 4 receiving HAART between 1995 and 2000 in Cape Town were compared with HIV-infected controls matched for baseline WHO stage, CD4 count, age, and socioeconomic status, who did not receive antiretroviral therapy (ART; No-ART group. Costs of service provision (January 2004 prices, US$1 = 7.6 Rand included local unit costs, and two scenarios for HAART prices for WHO recommended first-line regimens: scenario 1 used current South African public-sector ART drug prices of $730 per patient-year (PPY, whereas scenario 2 was based on the anticipated public-sector price for locally manufactured drug of $181 PPY. All analyses are presented in terms of patients without AIDS and patients with AIDS. For patients without AIDS, the mean number of inpatient days PPY was 1.08 (95% confidence interval [CI]: 0.97-1.19 for the HAART group versus 3.73 (95% CI: 3.55-3.97 for the No-ART group, and 8.71 (95% CI: 8.40-9.03 versus 4.35 (95% CI: 4.12-5.61, respectively, for mean number of outpatient visits PPY. Average service provision PPY was $950 for the No-ART group versus $1,342 and $793 PPY for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per life-year gained (LYG was $1,622 for scenario 1 and $675 for scenario 2. For patients with AIDS, mean inpatients days PPY was 2.04 (95% CI: 1.63-2.52 for the HAART versus 15.36 (95% CI: 13.97-16.85 for the No-ART group. Mean outpatient visits PPY was 7.62 (95% CI: 6.81-8.49 compared with 6.60 (95% CI: 5.69-7.62 respectively. Average service provision PPY was $3,520 for the No-ART group versus $1,513 and $964

  5. Cost-effectiveness of highly active antiretroviral therapy in South Africa.

    Directory of Open Access Journals (Sweden)

    Motasim Badri

    2006-01-01

    Full Text Available Little information exists on the impact of highly active antiretroviral therapy (HAART on health-care provision in South Africa despite increasing scale-up of access to HAART and gradual reduction in HAART prices.Use and cost of services for 265 HIV-infected adults without AIDS (World Health Organization [WHO] stage 1, 2, or 3 and 27 with AIDS (WHO stage 4 receiving HAART between 1995 and 2000 in Cape Town were compared with HIV-infected controls matched for baseline WHO stage, CD4 count, age, and socioeconomic status, who did not receive antiretroviral therapy (ART; No-ART group. Costs of service provision (January 2004 prices, USD 1 = 7.6 Rand included local unit costs, and two scenarios for HAART prices for WHO recommended first-line regimens: scenario 1 used current South African public-sector ART drug prices of $730 per patient-year (PPY, whereas scenario 2 was based on the anticipated public-sector price for locally manufactured drug of $181 PPY. All analyses are presented in terms of patients without AIDS and patients with AIDS. For patients without AIDS, the mean number of inpatient days PPY was 1.08 (95% confidence interval [CI]: 0.97-1.19 for the HAART group versus 3.73 (95% CI: 3.55-3.97 for the No-ART group, and 8.71 (95% CI: 8.40-9.03 versus 4.35 (95% CI: 4.12-5.61, respectively, for mean number of outpatient visits PPY. Average service provision PPY was $950 for the No-ART group versus $1,342 and $793 PPY for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per life-year gained (LYG was $1,622 for scenario 1 and $675 for scenario 2. For patients with AIDS, mean inpatients days PPY was 2.04 (95% CI: 1.63-2.52 for the HAART versus 15.36 (95% CI: 13.97-16.85 for the No-ART group. Mean outpatient visits PPY was 7.62 (95% CI: 6.81-8.49 compared with 6.60 (95% CI: 5.69-7.62 respectively. Average service provision PPY was $3,520 for the No-ART group versus $1,513 and $964 for the HAART group for scenario 1

  6. Nitrate transport and supply limitations quantified using high-frequency stream monitoring and turning point analysis

    Science.gov (United States)

    Jones, Christopher S.; Wang, Bo; Schilling, Keith E.; Chan, Kung-sik

    2017-06-01

    Agricultural landscapes often leak inorganic nitrogen to the stream network, usually in the form of nitrate-nitrite (NOx-N), degrading downstream water quality on both the local and regional scales. While the spatial distribution of nitrate sources has been delineated in many watersheds, less is known about the complicated temporal dynamics that drive stream NOx-N because traditional methods of stream grab sampling are often conducted at a low frequency. Deployment of accurate real-time, continuous measurement devices that have been developed in recent years enables high-frequency sampling that provides detailed information on the concentration-discharge relation and the timing of NOx-N delivery to streams. We aggregated 15-min interval NOx-N and discharge data over a nine-year period into daily averages and then used robust statistical methods to identify how the discharge regime within an artificially-drained agricultural watershed reflected catchment hydrology and NOx-N delivery pathways. We then quantified how transport and supply limitations varied from year-to-year and how dependence of these limitations varied with climate, especially drought. Our results show NOx-N concentrations increased linearly with discharge up to an average "turning point" of 1.42 mm of area-normalized discharge, after which concentrations decline with increasing discharge. We estimate transport and supply limitations to govern 57 and 43 percent, respectively, of the NOx-N flux over the nine-year period. Drought effects on the NOx-N flux linger for multiple years and this is reflected in a greater tendency toward supply limitations in the three years following drought. How the turning point varies with climate may aid in prediction of NOx-N loading in future climate regimes.

  7. The cost-effectiveness of intervening in low and high HIV prevalence areas in South Africa

    Directory of Open Access Journals (Sweden)

    Josue Mbonigaba

    2013-05-01

    Full Text Available This research compared the cost-effectiveness of a set of HIV/AIDS interventions in a low HIV prevalence area (LPA and in a high HIV prevalence area (HPA in South Africa. The rationale for this analysis was to assess the interaction dynamics between a specific HIV/AIDS intervention and an area of implementation and the effects of these dynamics on the cost-effectiveness of such an HIV/AIDS intervention. A pair of Markov models was evaluated for each intervention; one model for a HPA and another for an LPA and the cost-effectiveness of that intervention was compared across an LPA and a HPA. The baseline costs and health outcomes in each area were collected from the literature. To depict interaction dynamics between an HIV/AIDS intervention and an area of implementation, baseline health outcomes collected in each area, were adjusted over time based on the patterns of the projections observed in the AIDS model of the Actuarial Society of South Africa (ASSA2008. The study found that the VCT and treatment of STDs were equally cost-effective in an LPA and in a HPA while PMTCT and HAART were more cost-effective in an LPA than in a HPA. As a policy proposal, resources earmarked to non-ARV based interventions (VCT and treatment of STDs should  be equally shared across an LPA and a HPA while  more of the resources reserved for ARV-based interventions (PMTCT and HAART should go in an LPA in order to increase efficiency.

  8. High energy bursts from a solid state laser operated in the heat capacity limited regime

    Science.gov (United States)

    Albrecht, G.; George, E.V.; Krupke, W.F.; Sooy, W.; Sutton, S.B.

    1996-06-11

    High energy bursts are produced from a solid state laser operated in a heat capacity limited regime. Instead of cooling the laser, the active medium is thermally well isolated. As a result, the active medium will heat up until it reaches some maximum acceptable temperature. The waste heat is stored in the active medium itself. Therefore, the amount of energy the laser can put out during operation is proportional to its mass, the heat capacity of the active medium, and the temperature difference over which it is being operated. The high energy burst capacity of a heat capacity operated solid state laser, together with the absence of a heavy, power consuming steady state cooling system for the active medium, will make a variety of applications possible. Alternately, cooling takes place during a separate sequence when the laser is not operating. Industrial applications include new material working processes. 5 figs.

  9. VERITAS UPPER LIMIT ON THE VERY HIGH ENERGY EMISSION FROM THE RADIO GALAXY NGC 1275

    International Nuclear Information System (INIS)

    Acciari, V. A.; Benbow, W.; Aliu, E.; Boltuch, D.; Arlen, T.; Celik, O.; Aune, T.; Bautista, M.; Cogan, P.; Beilicke, M.; Buckley, J. H.; Bugaev, V.; Dickherber, R.; Bradbury, S. M.; Byrum, K.; Cannon, A.; Cesarini, A.; Ciupik, L.; Cui, W.; Duke, C.

    2009-01-01

    The recent detection by the Fermi γ-ray space telescope of high-energy γ-rays from the radio galaxy NGC 1275 makes the observation of the very high energy (VHE: E>100 GeV) part of its broadband spectrum particularly interesting, especially for the understanding of active galactic nuclei with misaligned multi-structured jets. The radio galaxy NGC 1275 was recently observed by VERITAS at energies above 100 GeV for about 8 hr. No VHE γ-ray emission was detected by VERITAS from NGC 1275. A 99% confidence level upper limit of 2.1% of the Crab Nebula flux level is obtained at the decorrelation energy of approximately 340 GeV, corresponding to 19% of the power-law extrapolation of the Fermi Large Area Telescope result.

  10. Chest wall restriction limits high airway pressure-induced lung injury in young rabbits.

    Science.gov (United States)

    Hernandez, L A; Peevy, K J; Moise, A A; Parker, J C

    1989-05-01

    High peak inspiratory pressures (PIP) during mechanical ventilation can induce lung injury. In the present study we compare the respective roles of high tidal volume with high PIP in intact immature rabbits to determine whether the increase in capillary permeability is the result of overdistension of the lung or direct pressure effects. New Zealand White rabbits were assigned to one of three protocols, which produced different degrees of inspiratory volume limitation: intact closed-chest animals (CC), closed-chest animals with a full-body plaster cast (C), and isolated excised lungs (IL). The intact animals were ventilated at 15, 30, or 45 cmH2O PIP for 1 h, and the lungs of the CC and C groups were placed in an isolated lung perfusion system. Microvascular permeability was evaluated using the capillary filtration coefficient (Kfc). Base-line Kfc for isolated lungs before ventilation was 0.33 +/- 0.31 ml.min-1.cmH2O-1.100g-1 and was not different from the Kfc in the CC group ventilated with 15 cmH2O PIP. Kfc increased by 850% after ventilation with only 15 cmH2O PIP in the unrestricted IL group, and in the CC group Kfc increased by 31% after 30 cmH2O PIP and 430% after 45 cmH2O PIP. Inspiratory volume limitation by the plaster cast in the C group prevented any significant increase in Kfc at the PIP values used. These data indicate that volume distension of the lung rather than high PIP per se produces microvascular damage in the immature rabbit lung.

  11. "Water-in-salt" electrolytes enable the use of cost-effective aluminum current collectors for aqueous high-voltage batteries.

    Science.gov (United States)

    Kühnel, R-S; Reber, D; Remhof, A; Figi, R; Bleiner, D; Battaglia, C

    2016-08-16

    The extended electrochemical stability window offered by highly concentrated electrolytes allows the operation of aqueous batteries at voltages significantly above the thermodynamic stability limit of water, at which the stability of the current collector potentially limits the cell voltage. Here we report the observation of suppressed anodic dissolution of aluminum in "water-in-salt" electrolytes enabling roll-to-roll electrode fabrication for high-voltage aqueous lithium-ion batteries on cost-effective light-weight aluminum current collectors using established lithium-ion battery technology.

  12. High contrast stellar observations within the diffraction limit at the Palomar Hale telescope

    Science.gov (United States)

    Mennesson, B.; Hanot, C.; Serabyn, E.; Martin, S. R.; Liewer, K.; Loya, F.; Mawet, D.

    2010-07-01

    We report on high-accuracy, high-resolution (statistical method, baptized "Null Self-Calibration" (NSC), which provides astrophysical null measurements at the 0.001 level, with 1 σ uncertainties as low as 0.0003. Such accuracy translates into a dynamic range greater than 1000:1 within the diffraction limit, demonstrating that the approach effectively bridges the traditional gap between regular coronagraphs, limited in angular resolution, and long baseline visibility interferometers, whose dynamic range is restricted to 100:1. As our measurements are extremely sensitive to the brightness distribution very close to the optical axis, we were able to constrain the stellar diameters and amounts of circumstellar emission for a sample of very bright stars. With the improvement expected when the PALM-3000 extreme AO system comes on-line at Palomar, the same instrument now equipped with a state of the art low noise fast read-out near IR camera, will yield 10-4 to 10-3 contrast as close as 30 mas for stars with K magnitude brighter than 6. Such a system will provide a unique and ideal tool for the detection of young (AUs) of nearby (< 50pc) stars.

  13. Status of high temperature superconductor cable and fault current limiter projects at American Superconductor

    International Nuclear Information System (INIS)

    Maguire, J.F.; Yuan, J.

    2009-01-01

    This paper will describe the status of three key programs currently underway at American Superconductor Corp. The first program is the LIPA project which is a transmission voltage high temperature superconducting cable program, with funding support from the US Department of Energy. The 600 m cable, capable of carrying 574 MVA, was successfully installed and commissioned in LIPA grid on April 22, 2008. An overview of the project, system level design details and operational data will be provided. In addition, the status of the newly awarded LIPA II project will be described. The second program is Project Hydra, with funding support from the US Department of Homeland Security, to design, develop and demonstrate an HTS cable with fault current limiting functionality. The cable is 300 m long and is being designed to carry 96 MVA at a distribution level voltage of 13.8 kV. The cable will be permanently installed and energized in Manhattan, New York in 2010. The initial status of Project Hydra will be presented. The final program to be discussed is a transmission voltage, high temperature superconducting fault current limiter funded by the US DOE. The project encompasses the design, construction and test of a 115 kV FCL for power transmission within a time frame of 4-5 years. Installation and testing are planned for a Southern California Edison substation. A project overview and progress under the first phase will be reported.

  14. Status of high temperature superconductor cable and fault current limiter projects at American Superconductor

    Energy Technology Data Exchange (ETDEWEB)

    Maguire, J.F., E-mail: jmaguire@amsc.co [American Superconductor Co., 64 Jackson Road, Devens, MA 01434 (United States); Yuan, J. [American Superconductor Co., 64 Jackson Road, Devens, MA 01434 (United States)

    2009-10-15

    This paper will describe the status of three key programs currently underway at American Superconductor Corp. The first program is the LIPA project which is a transmission voltage high temperature superconducting cable program, with funding support from the US Department of Energy. The 600 m cable, capable of carrying 574 MVA, was successfully installed and commissioned in LIPA grid on April 22, 2008. An overview of the project, system level design details and operational data will be provided. In addition, the status of the newly awarded LIPA II project will be described. The second program is Project Hydra, with funding support from the US Department of Homeland Security, to design, develop and demonstrate an HTS cable with fault current limiting functionality. The cable is 300 m long and is being designed to carry 96 MVA at a distribution level voltage of 13.8 kV. The cable will be permanently installed and energized in Manhattan, New York in 2010. The initial status of Project Hydra will be presented. The final program to be discussed is a transmission voltage, high temperature superconducting fault current limiter funded by the US DOE. The project encompasses the design, construction and test of a 115 kV FCL for power transmission within a time frame of 4-5 years. Installation and testing are planned for a Southern California Edison substation. A project overview and progress under the first phase will be reported.

  15. Status of high temperature superconductor cable and fault current limiter projects at American Superconductor

    Science.gov (United States)

    Maguire, J. F.; Yuan, J.

    2009-10-01

    This paper will describe the status of three key programs currently underway at American Superconductor Corp. The first program is the LIPA project which is a transmission voltage high temperature superconducting cable program, with funding support from the US Department of Energy. The 600 m cable, capable of carrying 574 MVA, was successfully installed and commissioned in LIPA grid on April 22, 2008. An overview of the project, system level design details and operational data will be provided. In addition, the status of the newly awarded LIPA II project will be described. The second program is Project Hydra, with funding support from the US Department of Homeland Security, to design, develop and demonstrate an HTS cable with fault current limiting functionality. The cable is 300 m long and is being designed to carry 96 MVA at a distribution level voltage of 13.8 kV. The cable will be permanently installed and energized in Manhattan, New York in 2010. The initial status of Project Hydra will be presented. The final program to be discussed is a transmission voltage, high temperature superconducting fault current limiter funded by the US DOE. The project encompasses the design, construction and test of a 115 kV FCL for power transmission within a time frame of 4-5 years. Installation and testing are planned for a Southern California Edison substation. A project overview and progress under the first phase will be reported.

  16. Rabbit System. Low cost, high reliability front end electronics featuring 16 bit dynamic range

    International Nuclear Information System (INIS)

    Drake, G.; Droege, T.F.; Nelson, C.A. Jr.; Turner, K.J.; Ohska, T.K.

    1985-10-01

    A new crate-based front end system has been built which features low cost, compact packaging, command capability, 16 bit dynamic range digitization, and a high degree of redundancy. The crate can contain a variety of instrumentation modules, and is designed to be situated close to the detector. The system is suitable for readout of a large number of channels via parallel multiprocessor data acquisition

  17. Low-Cost 3D Printers Enable High-Quality and Automated Sample Preparation and Molecular Detection.

    Directory of Open Access Journals (Sweden)

    Kamfai Chan

    Full Text Available Most molecular diagnostic assays require upfront sample preparation steps to isolate the target's nucleic acids, followed by its amplification and detection using various nucleic acid amplification techniques. Because molecular diagnostic methods are generally rather difficult to perform manually without highly trained users, automated and integrated systems are highly desirable but too costly for use at point-of-care or low-resource settings. Here, we showcase the development of a low-cost and rapid nucleic acid isolation and amplification platform by modifying entry-level 3D printers that cost between $400 and $750. Our modifications consisted of replacing the extruder with a tip-comb attachment that houses magnets to conduct magnetic particle-based nucleic acid extraction. We then programmed the 3D printer to conduct motions that can perform high-quality extraction protocols. Up to 12 samples can be processed simultaneously in under 13 minutes and the efficiency of nucleic acid isolation matches well against gold-standard spin-column-based extraction technology. Additionally, we used the 3D printer's heated bed to supply heat to perform water bath-based polymerase chain reactions (PCRs. Using another attachment to hold PCR tubes, the 3D printer was programmed to automate the process of shuttling PCR tubes between water baths. By eliminating the temperature ramping needed in most commercial thermal cyclers, the run time of a 35-cycle PCR protocol was shortened by 33%. This article demonstrates that for applications in resource-limited settings, expensive nucleic acid extraction devices and thermal cyclers that are used in many central laboratories can be potentially replaced by a device modified from inexpensive entry-level 3D printers.

  18. Low-Cost 3D Printers Enable High-Quality and Automated Sample Preparation and Molecular Detection

    Science.gov (United States)

    Chan, Kamfai; Coen, Mauricio; Hardick, Justin; Gaydos, Charlotte A.; Wong, Kah-Yat; Smith, Clayton; Wilson, Scott A.; Vayugundla, Siva Praneeth; Wong, Season

    2016-01-01

    Most molecular diagnostic assays require upfront sample preparation steps to isolate the target’s nucleic acids, followed by its amplification and detection using various nucleic acid amplification techniques. Because molecular diagnostic methods are generally rather difficult to perform manually without highly trained users, automated and integrated systems are highly desirable but too costly for use at point-of-care or low-resource settings. Here, we showcase the development of a low-cost and rapid nucleic acid isolation and amplification platform by modifying entry-level 3D printers that cost between $400 and $750. Our modifications consisted of replacing the extruder with a tip-comb attachment that houses magnets to conduct magnetic particle-based nucleic acid extraction. We then programmed the 3D printer to conduct motions that can perform high-quality extraction protocols. Up to 12 samples can be processed simultaneously in under 13 minutes and the efficiency of nucleic acid isolation matches well against gold-standard spin-column-based extraction technology. Additionally, we used the 3D printer’s heated bed to supply heat to perform water bath-based polymerase chain reactions (PCRs). Using another attachment to hold PCR tubes, the 3D printer was programmed to automate the process of shuttling PCR tubes between water baths. By eliminating the temperature ramping needed in most commercial thermal cyclers, the run time of a 35-cycle PCR protocol was shortened by 33%. This article demonstrates that for applications in resource-limited settings, expensive nucleic acid extraction devices and thermal cyclers that are used in many central laboratories can be potentially replaced by a device modified from inexpensive entry-level 3D printers. PMID:27362424

  19. Advantages and Limits of 4H-SIC Detectors for High- and Low-Flux Radiations

    Science.gov (United States)

    Sciuto, A.; Torrisi, L.; Cannavò, A.; Mazzillo, M.; Calcagno, L.

    2017-11-01

    Silicon carbide (SiC) detectors based on Schottky diodes were used to monitor low and high fluxes of photons and ions. An appropriate choice of the epilayer thickness and geometry of the surface Schottky contact allows the tailoring and optimizing the detector efficiency. SiC detectors with a continuous front electrode were employed to monitor alpha particles in a low-flux regime emitted by a radioactive source with high energy (>5.0 MeV) or generated in an ion implanter with sub-MeV energy. An energy resolution value of 0.5% was measured in the high energy range, while, at energy below 1.0 MeV, the resolution becomes 10%; these values are close to those measured with a traditional silicon detector. The same SiC devices were used in a high-flux regime to monitor high-energy ions, x-rays and electrons of the plasma generated by a high-intensity (1016 W/cm2) pulsed laser. Furthermore, SiC devices with an interdigit Schottky front electrode were proposed and studied to overcome the limits of the such SiC detectors in the detection of low-energy (˜1.0 keV) ions and photons of the plasmas generated by a low-intensity (1010 W/cm2) pulsed laser. SiC detectors are expected to be a powerful tool for the monitoring of radioactive sources and ion beams produced by accelerators, for a complete characterization of radiations emitted from laser-generated plasmas at high and low temperatures, and for dosimetry in a radioprotection field.

  20. The Limited Role of Number of Nested Syntactic Dependencies in Accounting for Processing Cost: Evidence from German Simplex and Complex Verbal Clusters

    Directory of Open Access Journals (Sweden)

    Markus Bader

    2018-01-01

    Full Text Available This paper presents three acceptability experiments investigating German verb-final clauses in order to explore possible sources of sentence complexity during human parsing. The point of departure was De Vries et al.'s (2011 generalization that sentences with three or more crossed or nested dependencies are too complex for being processed by the human parsing mechanism without difficulties. This generalization is partially based on findings from Bach et al. (1986 concerning the acceptability of complex verb clusters in German and Dutch. The first experiment tests this generalization by comparing two sentence types: (i sentences with three nested dependencies within a single clause that contains three verbs in a complex verb cluster; (ii sentences with four nested dependencies distributed across two embedded clauses, one center-embedded within the other, each containing a two-verb cluster. The results show that sentences with four nested dependencies are judged as acceptable as control sentences with only two nested dependencies, whereas sentences with three nested dependencies are judged as only marginally acceptable. This argues against De Vries et al.'s (2011 claim that the human parser can process no more than two nested dependencies. The results are used to refine the Verb-Cluster Complexity Hypothesis of Bader and Schmid (2009a. The second and the third experiment investigate sentences with four nested dependencies in more detail in order to explore alternative sources of sentence complexity: the number of predicted heads to be held in working memory (storage cost in terms of the Dependency Locality Theory [DLT], Gibson, 2000 and the length of the involved dependencies (integration cost in terms of the DLT. Experiment 2 investigates sentences for which storage cost and integration cost make conflicting predictions. The results show that storage cost outweighs integration cost. Experiment 3 shows that increasing integration cost in sentences

  1. Cost estimate of high-level radioactive waste containers for the Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Russell, E.W.; Clarke, W. [Lawrence Livermore National Lab., CA (United States); Domian, H.A. [Babcock and Wilcox Co., Lynchburg, VA (United States); Madson, A.A. [Kaiser Engineers California Corp., Oakland, CA (United States)

    1991-08-01

    This report summarizes the bottoms-up cost estimates for fabrication of high-level radioactive waste disposal containers based on the Site Characterization Plan Conceptual Design (SCP-CD). These estimates were acquired by Babcock and Wilcox (B&S) under sub-contract to Lawrence Livermore National Laboratory (LLNL) for the Yucca Mountain Site Characterization Project (YMP). The estimates were obtained for two leading container candidate materials (Alloy 825 and CDA 715), and from other three vendors who were selected from a list of twenty solicited. Three types of container designs were analyzed that represent containers for spent fuel, and for vitrified high-level waste (HLW). The container internal structures were assumed to be AISI-304 stainless steel in all cases, with an annual production rate of 750 containers. Subjective techniques were used for estimating QA/QC costs based on vendor experience and the specifications derived for the LLNL-YMP Quality Assurance program. In addition, an independent QA/QC analysis is reported which was prepared by Kasier Engineering. Based on the cost estimates developed, LLNL recommends that values of $825K and $62K be used for the 1991 TSLCC for the spent fuel and HLW containers, respectively. These numbers represent the most conservative among the three vendors, and are for the high-nickel anstenitic steel (Alloy 825). 6 refs., 7 figs.

  2. Covariates of depression and high utilizers of healthcare: Impact on resource use and costs.

    Science.gov (United States)

    Robinson, Rebecca L; Grabner, Michael; Palli, Swetha Rao; Faries, Douglas; Stephenson, Judith J

    2016-06-01

    To characterize healthcare costs, resource use, and treatment patterns of survey respondents with a history of depression who are high utilizers (HUds) of healthcare and to identify factors associated with high utilization. Adults with two or more depression diagnoses identified from the HealthCore Integrated Research Database were invited to participate in the CODE study, which links survey data with 12-month retrospective claims data. Patient surveys provided data on demographics, general health, and symptoms and/or comorbidities associated with depression. Similar clinical conditions also were identified from the medical claims. Factors associated with high utilization were identified using logistic regression models. Of 3132 survey respondents, 1921 were included, 193 of whom were HUds (defined as those who incurred the top 10% of total all-cause costs in the preceding 12months). Mean total annual healthcare costs were eightfold greater for HUds than for non-HUds ($US56,145 vs. $US6,954; pcosts/resource use. HUds were prescribed twice as many medications (total mean: 16.86 vs. 8.32; psychotropic mean: 4.11 vs. 2.61; both pcosts in patients with depression. Copyright © 2016 Eli Lilly and Company. Published by Elsevier Inc. All rights reserved.

  3. Cost estimate of high-level radioactive waste containers for the Yucca Mountain Site Characterization Project

    International Nuclear Information System (INIS)

    Russell, E.W.; Clarke, W.; Domian, H.A.; Madson, A.A.

    1991-08-01

    This report summarizes the bottoms-up cost estimates for fabrication of high-level radioactive waste disposal containers based on the Site Characterization Plan Conceptual Design (SCP-CD). These estimates were acquired by Babcock and Wilcox (B ampersand S) under sub-contract to Lawrence Livermore National Laboratory (LLNL) for the Yucca Mountain Site Characterization Project (YMP). The estimates were obtained for two leading container candidate materials (Alloy 825 and CDA 715), and from other three vendors who were selected from a list of twenty solicited. Three types of container designs were analyzed that represent containers for spent fuel, and for vitrified high-level waste (HLW). The container internal structures were assumed to be AISI-304 stainless steel in all cases, with an annual production rate of 750 containers. Subjective techniques were used for estimating QA/QC costs based on vendor experience and the specifications derived for the LLNL-YMP Quality Assurance program. In addition, an independent QA/QC analysis is reported which was prepared by Kasier Engineering. Based on the cost estimates developed, LLNL recommends that values of $825K and $62K be used for the 1991 TSLCC for the spent fuel and HLW containers, respectively. These numbers represent the most conservative among the three vendors, and are for the high-nickel anstenitic steel (Alloy 825). 6 refs., 7 figs

  4. Cost-effectiveness analysis of online hemodiafiltration versus high-flux hemodialysis

    Directory of Open Access Journals (Sweden)

    Ramponi F

    2016-09-01

    Full Text Available Francesco Ramponi,1,2 Claudio Ronco,1,3 Giacomo Mason,1 Enrico Rettore,4 Daniele Marcelli,5,6 Francesca Martino,1,3 Mauro Neri,1,7 Alejandro Martin-Malo,8 Bernard Canaud,5,9 Francesco Locatelli10 1International Renal Research Institute (IRRIV, San Bortolo Hospital, Vicenza, 2Department of Economics and Management, University of Padova, Padova, 3Department of Nephrology, San Bortolo Hospital, Vicenza, 4Department of Sociology and Social Research, University of Trento, FBK-IRVAPP & IZA, Trento, Italy; 5Europe, Middle East, Africa and Latin America Medical Board, Fresenius Medical Care,, Bad Homburg, Germany; 6Danube University, Krems, Austria; 7Department of Management and Engineering, University of Padova, Vicenza, Italy; 8Nephrology Unit, Reina Sofia University Hospital, Córdoba, Spain; 9School of Medicine, Montpellier University, Montpellier, France; 10Department of Nephrology, Manzoni Hospital, Lecco, Italy Background: Clinical studies suggest that hemodiafiltration (HDF may lead to better clinical outcomes than high-flux hemodialysis (HF-HD, but concerns have been raised about the cost-effectiveness of HDF versus HF-HD. Aim of this study was to investigate whether clinical benefits, in terms of longer survival and better health-related quality of life, are worth the possibly higher costs of HDF compared to HF-HD.Methods: The analysis comprised a simulation based on the combined results of previous published studies, with the following steps: 1 estimation of the survival function of HF-HD patients from a clinical trial and of HDF patients using the risk reduction estimated in a meta-analysis; 2 simulation of the survival of the same sample of patients as if allocated to HF-HD or HDF using three-state Markov models; and 3 application of state-specific health-related quality of life coefficients and differential costs derived from the literature. Several Monte Carlo simulations were performed, including simulations for patients with different

  5. Low-cost, high-performance and efficiency computational photometer design

    Science.gov (United States)

    Siewert, Sam B.; Shihadeh, Jeries; Myers, Randall; Khandhar, Jay; Ivanov, Vitaly

    2014-05-01

    Researchers at the University of Alaska Anchorage and University of Colorado Boulder have built a low cost high performance and efficiency drop-in-place Computational Photometer (CP) to test in field applications ranging from port security and safety monitoring to environmental compliance monitoring and surveying. The CP integrates off-the-shelf visible spectrum cameras with near to long wavelength infrared detectors and high resolution digital snapshots in a single device. The proof of concept combines three or more detectors into a single multichannel imaging system that can time correlate read-out, capture, and image process all of the channels concurrently with high performance and energy efficiency. The dual-channel continuous read-out is combined with a third high definition digital snapshot capability and has been designed using an FPGA (Field Programmable Gate Array) to capture, decimate, down-convert, re-encode, and transform images from two standard definition CCD (Charge Coupled Device) cameras at 30Hz. The continuous stereo vision can be time correlated to megapixel high definition snapshots. This proof of concept has been fabricated as a fourlayer PCB (Printed Circuit Board) suitable for use in education and research for low cost high efficiency field monitoring applications that need multispectral and three dimensional imaging capabilities. Initial testing is in progress and includes field testing in ports, potential test flights in un-manned aerial systems, and future planned missions to image harsh environments in the arctic including volcanic plumes, ice formation, and arctic marine life.

  6. Systems costs for disposal of Savannah River high-level waste sludge and salt

    International Nuclear Information System (INIS)

    McDonell, W.R.; Goodlett, C.B.

    1984-01-01

    A systems cost model has been developed to support disposal of defense high-level waste sludge and salt generated at the Savannah River Plant. Waste processing activities covered by the model include decontamination of the salt by a precipitation process in the waste storage tanks, incorporation of the sludge and radionuclides removed from the salt into glass in the Defense Waste Processing Facility (DWPF), and, after interim storage, final disposal of the DWPF glass waste canisters in a federal geologic repository. Total costs for processing of waste generated to the year 2000 are estimated to be about $2.9 billion (1984 dollars); incremental unit costs for DWPF and repository disposal activities range from $120,000 to $170,000 per canister depending on DWPF processing schedules. In a representative evaluation of process alternatives, the model is used to demonstrate cost effectiveness of adjustments in the frit content of the waste glass to reduce impacts of wastes generated by the salt decontamination operations. 13 references, 8 tables

  7. Cost comparison of very high temperature nuclear reactors for process heat applications

    International Nuclear Information System (INIS)

    Crowley, J.H.; Newman, J.B.

    1975-03-01

    In April 1974, the United States Atomic Energy Commission (USAEC) authorized General Atomic Company, General Electric Company and Westinghouse Astronuclear Laboratory to assess the available technology for producing process heat utilizing very high temperature nuclear reactors. General Electric and Westinghouse produced concepts for the entire nuclear system, including the balance of plant. The General Atomic assessment included only the nuclear reactor portion of the nuclear plant. United Engineers and Constructors Inc. (UE and C) was requested by the USAEC in November 1974 to prepare an economic comparison of the three conceptual plants. The comparison is divided into three tasks: (1) Develop a balance of plant conceptual design to be combined with the General Atomic concept as a basis for comparison, and estimate the cost of the General Atomic/UE and C concept in July 1974 dollars; (2) Normalize the overall plant costs for the General Atomic/UE and C, General Electric and Westinghouse concepts, compare the costs, and identify significant differences between the concepts; and (3) Estimate the operation and maintenance costs for the General Atomic/UE and C plant and compare with the other concepts. The results of these task studies are discussed

  8. SETTING UP OF A HOMECARE SYSTEM FOR HIGH COST NEBULISERS IN A PAEDIATRIC CYSTIC FIBROSIS CENTRE.

    Science.gov (United States)

    Chorro-Mari, Veronica; Christiansen, Nanna

    2016-09-01

    Due to national changes to the commissioning process of high cost nebulisers (HCN) for Cystic Fibrosis (CF) patients, CF centres have to repatriate the prescribing of the HCN to the tertiary care centres.1 The following nebulisers will no longer be prescribed by primary care: Cayston® (Aztreonam); Colomycin®, Pomixin®, Clobreathe® (Colistimethate); Pulmozyme® (Dornase alfa); Tobi®, Tobi Podhaler ®, Bramitob® (Tobramycin).This abstract explains how the Royal London Hospital (RLH) Paediatric Pharmacy recruited over 100 paediatric (CF) patients smoothly within a period of 4 months and set up a homecare system to avoid patients and families having to travel large distances to obtain their medication. A number of homecare companies were evaluated initially. Parameters looked at were reports of customer satisfaction, delivery cost, turn-around time once the prescription was received and availability of same day delivery service.In order to capture existing patients we met with CF Specialist Nurses to establish the total number of patients on HCN, what nebulised treatment they were on and their respective doses. We prioritised patients that had known problems with GP prescribing and anybody newly starting on HCN.To communicate the change to parents, a letter was sent to all parents explaining the changeover to homecare delivery and tertiary prescribing. In addition a section in the parent bulletin was dedicated to the topic as well. Following this we contacted parents via phone and in clinic to request consent and explain the process.Up to 10 patients were contacted weekly (average of 7); the consent form and registration form were then faxed to the Homecare company for patient registration. In parallel to this prescriptions were requested for the patients that had been set up in the previous week, ensuring that prescribing was spread out over time to avoid having peak times for repeat prescriptions.In addition to the letter to parents GP surgeries were also

  9. Investigation of the limitations of the highly pixilated CdZnTe detector for PET applications.

    Science.gov (United States)

    Komarov, Sergey; Yin, Yongzhi; Wu, Heyu; Wen, Jie; Krawczynski, Henric; Meng, Ling-Jian; Tai, Yuan-Chuan

    2012-11-21

    We are investigating the feasibility of a high resolution positron emission tomography (PET) insert device based on the CdZnTe detector with 350 µm anode pixel pitch to be integrated into a conventional animal PET scanner to improve its image resolution. In this paper, we have used a simplified version of the multi pixel CdZnTe planar detector, 5 mm thick with 9 anode pixels only. This simplified 9 anode pixel structure makes it possible to carry out experiments without a complete application-specific integrated circuits readout system that is still under development. Special attention was paid to the double pixel (or charge sharing) detections. The following characteristics were obtained in experiment: energy resolution full-width-at-half-maximum (FWHM) is 7% for single pixel and 9% for double pixel photoelectric detections of 511 keV gammas; timing resolution (FWHM) from the anode signals is 30 ns for single pixel and 35 ns for double pixel detections (for photoelectric interactions only the corresponding values are 20 and 25 ns); position resolution is 350 µm in x,y-plane and ∼0.4 mm in depth-of-interaction. The experimental measurements were accompanied by Monte Carlo (MC) simulations to find a limitation imposed by spatial charge distribution. Results from MC simulations suggest the limitation of the intrinsic spatial resolution of the CdZnTe detector for 511 keV photoelectric interactions is 170 µm. The interpixel interpolation cannot recover the resolution beyond the limit mentioned above for photoelectric interactions. However, it is possible to achieve higher spatial resolution using interpolation for Compton scattered events. Energy and timing resolution of the proposed 350 µm anode pixel pitch detector is no better than 0.6% FWHM at 511 keV, and 2 ns FWHM, respectively. These MC results should be used as a guide to understand the performance limits of the pixelated CdZnTe detector due to the underlying detection processes, with the understanding of

  10. A high resolution IR/visible imaging system for the W7-X limiter

    International Nuclear Information System (INIS)

    Wurden, G. A.; Dunn, J. P.; Stephey, L. A.; Biedermann, C.; Jakubowski, M. W.; Gamradt, M.

    2016-01-01

    A high-resolution imaging system, consisting of megapixel mid-IR and visible cameras along the same line of sight, has been prepared for the new W7-X stellarator and was operated during Operational Period 1.1 to view one of the five inboard graphite limiters. The radial line of sight, through a large diameter (184 mm clear aperture) uncoated sapphire window, couples a direct viewing 1344 × 784 pixel FLIR SC8303HD camera. A germanium beam-splitter sends visible light to a 1024 × 1024 pixel Allied Vision Technologies Prosilica GX1050 color camera. Both achieve sub-millimeter resolution on the 161 mm wide, inertially cooled, segmented graphite tiles. The IR and visible cameras are controlled via optical fibers over full Camera Link and dual GigE Ethernet (2 Gbit/s data rates) interfaces, respectively. While they are mounted outside the cryostat at a distance of 3.2 m from the limiter, they are close to a large magnetic trim coil and require soft iron shielding. We have taken IR data at 125 Hz to 1.25 kHz frame rates and seen that surface temperature increases in excess of 350 °C, especially on leading edges or defect hot spots. The IR camera sees heat-load stripe patterns on the limiter and has been used to infer limiter power fluxes (∼1–4.5 MW/m"2), during the ECRH heating phase. IR images have also been used calorimetrically between shots to measure equilibrated bulk tile temperature, and hence tile energy inputs (in the range of 30 kJ/tile with 0.6 MW, 6 s heating pulses). Small UFO’s can be seen and tracked by the FLIR camera in some discharges. The calibrated visible color camera (100 Hz frame rate) has also been equipped with narrow band C-III and H-alpha filters, to compare with other diagnostics, and is used for absolute particle flux determination from the limiter surface. Sometimes, but not always, hot-spots in the IR are also seen to be bright in C-III light.

  11. A high resolution IR/visible imaging system for the W7-X limiter

    Energy Technology Data Exchange (ETDEWEB)

    Wurden, G. A., E-mail: wurden@lanl.gov; Dunn, J. P. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Stephey, L. A. [University of Wisconsin, Madison, Wisconsin 53706 (United States); Biedermann, C.; Jakubowski, M. W.; Gamradt, M. [Max Planck Institut für Plasma Physik, Wendelsteinstrasse 1, 17491 Greifswald (Germany)

    2016-11-15

    A high-resolution imaging system, consisting of megapixel mid-IR and visible cameras along the same line of sight, has been prepared for the new W7-X stellarator and was operated during Operational Period 1.1 to view one of the five inboard graphite limiters. The radial line of sight, through a large diameter (184 mm clear aperture) uncoated sapphire window, couples a direct viewing 1344 × 784 pixel FLIR SC8303HD camera. A germanium beam-splitter sends visible light to a 1024 × 1024 pixel Allied Vision Technologies Prosilica GX1050 color camera. Both achieve sub-millimeter resolution on the 161 mm wide, inertially cooled, segmented graphite tiles. The IR and visible cameras are controlled via optical fibers over full Camera Link and dual GigE Ethernet (2 Gbit/s data rates) interfaces, respectively. While they are mounted outside the cryostat at a distance of 3.2 m from the limiter, they are close to a large magnetic trim coil and require soft iron shielding. We have taken IR data at 125 Hz to 1.25 kHz frame rates and seen that surface temperature increases in excess of 350 °C, especially on leading edges or defect hot spots. The IR camera sees heat-load stripe patterns on the limiter and has been used to infer limiter power fluxes (∼1–4.5 MW/m{sup 2}), during the ECRH heating phase. IR images have also been used calorimetrically between shots to measure equilibrated bulk tile temperature, and hence tile energy inputs (in the range of 30 kJ/tile with 0.6 MW, 6 s heating pulses). Small UFO’s can be seen and tracked by the FLIR camera in some discharges. The calibrated visible color camera (100 Hz frame rate) has also been equipped with narrow band C-III and H-alpha filters, to compare with other diagnostics, and is used for absolute particle flux determination from the limiter surface. Sometimes, but not always, hot-spots in the IR are also seen to be bright in C-III light.

  12. Sensory shelf-life limiting factor of high hydrostatic pressure processed avocado paste.

    Science.gov (United States)

    Jacobo-Velázquez, D A; Hernández-Brenes, C

    2011-08-01

    High hydrostatic pressure (HHP) processing pasteurizes avocado paste without a significant impact on flavor. Although HHP-treated avocado paste stored under refrigeration is safe for human consumption for months, sensory changes taking place during storage cause the rejection of the product by consumers within days. Although it is known that the shelf life of the product ends before its microbial counts are high, its sensory shelf life limiting factor remains unknown. The present study focused on the use of a trained panel and a consumer panel to determine the sensory shelf life limiting factor of HHP-treated avocado paste. The trained panel identified sour and rancid flavors as the main sensory descriptors (critical descriptors) that differentiated stored from freshly processed samples. Further data obtained from consumers identified sour flavor as the main cause for a significant decrease in the acceptability (shelf life limiting factor) of refrigerated HHP-treated avocado paste. The study allowed the elucidation of a proposed deterioration mechanism for HHP-treated avocado paste during its refrigerated shelf life. The information through this work enhances scientific knowledge of the product and proposes the sour flavor development during storage as a relevant sensory attribute that needs to be improved in order to enhance the product shelf life. At present, HHP is the most effective commercial nonthermal technology to process avocado paste when compared to thermal and chemical alternatives. HHP-treated avocado paste is a microbiologically stable food for a period of at least 45 d stored under refrigeration. However, previous published work indicated that consumers rejected the product after approximately 19 d of storage due to sensory changes. This manuscript presents a sensory study that permitted the identification of the critical sensory descriptor that is acting as the sensory shelf life limiting factor of the product. The data presented herein along with

  13. Model of investment appraisal of high-rise construction with account of cost of land resources

    Science.gov (United States)

    Okolelova, Ella; Shibaeva, Marina; Trukhina, Natalya

    2018-03-01

    The article considers problems and potential of high-rise construction as a global urbanization. The results of theoretical and practical studies on the appraisal of investments in high-rise construction are provided. High-rise construction has a number of apparent upsides in modern terms of development of megapolises and primarily it is economically efficient. Amid serious lack of construction sites, skyscrapers successfully deal with the need of manufacturing, office and living premises. Nevertheless, there are plenty issues, which are related with high-rise construction, and only thorough scrutiny of them allow to estimate the real economic efficiency of this branch. The article focuses on the question of economic efficiency of high-rise construction. The suggested model allows adjusting the parameters of a facility under construction, setting the tone for market value as well as the coefficient for appreciation of the construction net cost, that depends on the number of storey's, in the form of function or discrete values.

  14. High heat flux testing impact on the Tore Supra toroidal pumped limiter achievement

    International Nuclear Information System (INIS)

    Schlosser, J.; Escourbiac, F.; Cordier, J.J.; Mitteau, R.; Durocher, A.; Grosman, A.

    2003-01-01

    The toroidal pumped limiter of Tore Supra is made of 576 elementary high heat flux (HHF) cooled plasma-facing components (PFCs) and designed to sustain 10 MW/m 2 in steady state. One of the main technical difficulties is to ensure a high quality of the bond between the carbon fiber composite armor tile and the water-cooled heat sink due to the high thermal stresses that develop at the bond during operation. Consequently, a HHF facility able to reproduce in service operation of PFCs is required all along the development and manufacturing route. In Europe, the FE200 facility (electron beam, 200 kW, France) operating since 1991, was extensively used for such a development. A first testing campaign in 1995 was devoted to the qualification of this bond: AMC technology from Plansee GmbH was selected. Afterwards, a second campaign on scale-one elements (1996) allowed an optimization of the element design and series production to be launched. During the mass production, a non-destructive control process - cheaper and faster than HHF testing - based on infrared characterization was routinely operated on 100% of the manufactured elements. Strong variability of the bond quality was observed and a repair process allowing the replacement of deficient tiles was developed. In 2000 and 2001, 2 campaigns of HHF testing were launched to correlate the non-destructive measurements and to optimize and validate the repair process. This was done, in two steps, with success. This yielded moreover interesting information for qualifying both tests across each other and also to analyze the fatigue evolution of the bond. The qualification and the achievement of the Tore Supra limiter has greatly been made possible by such HHF tests, which appears as essential before and during PFC manufacturing. (authors)

  15. Kite aerial photography for low-cost, ultra-high spatial resolution multi-spectral mapping of intertidal landscapes.

    Directory of Open Access Journals (Sweden)

    Mitch Bryson

    Full Text Available Intertidal ecosystems have primarily been studied using field-based sampling; remote sensing offers the ability to collect data over large areas in a snapshot of time that could complement field-based sampling methods by extrapolating them into the wider spatial and temporal context. Conventional remote sensing tools (such as satellite and aircraft imaging provide data at limited spatial and temporal resolutions and relatively high costs for small-scale environmental science and ecologically-focussed studies. In this paper, we describe a low-cost, kite-based imaging system and photogrammetric/mapping procedure that was developed for constructing high-resolution, three-dimensional, multi-spectral terrain models of intertidal rocky shores. The processing procedure uses automatic image feature detection and matching, structure-from-motion and photo-textured terrain surface reconstruction algorithms that require minimal human input and only a small number of ground control points and allow the use of cheap, consumer-grade digital cameras. The resulting maps combine imagery at visible and near-infrared wavelengths and topographic information at sub-centimeter resolutions over an intertidal shoreline 200 m long, thus enabling spatial properties of the intertidal environment to be determined across a hierarchy of spatial scales. Results of the system are presented for an intertidal rocky shore at Jervis Bay, New South Wales, Australia. Potential uses of this technique include mapping of plant (micro- and macro-algae and animal (e.g. gastropods assemblages at multiple spatial and temporal scales.

  16. Kite aerial photography for low-cost, ultra-high spatial resolution multi-spectral mapping of intertidal landscapes.

    Science.gov (United States)

    Bryson, Mitch; Johnson-Roberson, Matthew; Murphy, Richard J; Bongiorno, Daniel

    2013-01-01

    Intertidal ecosystems have primarily been studied using field-based sampling; remote sensing offers the ability to collect data over large areas in a snapshot of time that could complement field-based sampling methods by extrapolating them into the wider spatial and temporal context. Conventional remote sensing tools (such as satellite and aircraft imaging) provide data at limited spatial and temporal resolutions and relatively high costs for small-scale environmental science and ecologically-focussed studies. In this paper, we describe a low-cost, kite-based imaging system and photogrammetric/mapping procedure that was developed for constructing high-resolution, three-dimensional, multi-spectral terrain models of intertidal rocky shores. The processing procedure uses automatic image feature detection and matching, structure-from-motion and photo-textured terrain surface reconstruction algorithms that require minimal human input and only a small number of ground control points and allow the use of cheap, consumer-grade digital cameras. The resulting maps combine imagery at visible and near-infrared wavelengths and topographic information at sub-centimeter resolutions over an intertidal shoreline 200 m long, thus enabling spatial properties of the intertidal environment to be determined across a hierarchy of spatial scales. Results of the system are presented for an intertidal rocky shore at Jervis Bay, New South Wales, Australia. Potential uses of this technique include mapping of plant (micro- and macro-algae) and animal (e.g. gastropods) assemblages at multiple spatial and temporal scales.

  17. Clinical effectiveness and cost-effectiveness of fissure sealants in children and adolescents with a high caries risk

    Directory of Open Access Journals (Sweden)

    Neusser, Silke

    2014-10-01

    Full Text Available [english] In Germany, the application of resin-based pits and fissures sealants on the occlusal surfaces of permanent molars is part of individual prophylaxis for children and adolescents between six and 18 years. The individual prophylaxis is covered by the Statutory Health Insurance since 1993.The report addresses questions on medical effectiveness, cost-effectiveness, as well as ethical, social, and legal implications of pit and fissure sealants in preventing dental caries for children and adolescents at high caries risk. The results of the studies indicate a protective effect of pit and fissure sealants, particularly for children and adolescents at high caries risk. Additionally, the economic evaluation suggests a tendency for cost savings in this group. Nevertheless, a general expansion of the intervention cannot be recommended. All studies show a risk of bias in favour of pit and fissure sealing and a limited transferability to the German health care system. Studies included in the economic evaluation revealed methodological flaws. Both the economic models and primary studies do not provide reliable results.

  18. High Z neoclassical transport: Application and limitation of analytical formulae for modelling JET experimental parameters

    Science.gov (United States)

    Breton, S.; Casson, F. J.; Bourdelle, C.; Angioni, C.; Belli, E.; Camenen, Y.; Citrin, J.; Garbet, X.; Sarazin, Y.; Sertoli, M.; JET Contributors

    2018-01-01

    Heavy impurities, such as tungsten (W), can exhibit strongly poloidally asymmetric density profiles in rotating or radio frequency heated plasmas. In the metallic environment of JET, the poloidal asymmetry of tungsten enhances its neoclassical transport up to an order of magnitude, so that neoclassical convection dominates over turbulent transport in the core. Accounting for asymmetries in neoclassical transport is hence necessary in the integrated modeling framework. The neoclassical drift kinetic code, NEO [E. Belli and J. Candy, Plasma Phys. Controlled Fusion P50, 095010 (2008)], includes the impact of poloidal asymmetries on W transport. However, the computational cost required to run NEO slows down significantly integrated modeling. A previous analytical formulation to describe heavy impurity neoclassical transport in the presence of poloidal asymmetries in specific collisional regimes [C. Angioni and P. Helander, Plasma Phys. Controlled Fusion 56, 124001 (2014)] is compared in this work to numerical results from NEO. Within the domain of validity of the formula, the factor for reducing the temperature screening due to poloidal asymmetries had to be empirically adjusted. After adjustment, the modified formula can reproduce NEO results outside of its definition domain, with some limitations: When main ions are in the banana regime, the formula reproduces NEO results whatever the collisionality regime of impurities, provided that the poloidal asymmetry is not too large. However, for very strong poloidal asymmetries, agreement requires impurities in the Pfirsch-Schlüter regime. Within the JETTO integrated transport code, the analytical formula combined with the poloidally symmetric neoclassical code NCLASS [W. A. Houlberg et al., Phys. Plasmas 4, 3230 (1997)] predicts the same tungsten profile as NEO in certain cases, while saving a factor of one thousand in computer time, which can be useful in scoping studies. The parametric dependencies of the temperature

  19. Discovery of high-performance low-cost n-type Mg3Sb2-based thermoelectric materials with multi-valley conduction bands

    DEFF Research Database (Denmark)

    Zhang, Jiawei; Song, Lirong; Pedersen, Steffen Hindborg

    2017-01-01

    Widespread application of thermoelectric devices for waste heat recovery requires low-cost high-performance materials. The currently available n-type thermoelectric materials are limited either by their low efficiencies or by being based on expensive, scarce or toxic elements. Here we report a low-cost...... because of the multi-valley band behaviour dominated by a unique near-edge conduction band with a sixfold valley degeneracy. This makes Te-doped Mg3Sb1.5Bi0.5 a promising candidate for the low- and intermediate-temperature thermoelectric applications....

  20. Highly Efficient Perovskite-Perovskite Tandem Solar Cells Reaching 80% of the Theoretical Limit in Photovoltage.

    Science.gov (United States)

    Rajagopal, Adharsh; Yang, Zhibin; Jo, Sae Byeok; Braly, Ian L; Liang, Po-Wei; Hillhouse, Hugh W; Jen, Alex K-Y

    2017-09-01

    Organic-inorganic hybrid perovskite multijunction solar cells have immense potential to realize power conversion efficiencies (PCEs) beyond the Shockley-Queisser limit of single-junction solar cells; however, they are limited by large nonideal photovoltage loss (V oc,loss ) in small- and large-bandgap subcells. Here, an integrated approach is utilized to improve the V oc of subcells with optimized bandgaps and fabricate perovskite-perovskite tandem solar cells with small V oc,loss . A fullerene variant, Indene-C 60 bis-adduct, is used to achieve optimized interfacial contact in a small-bandgap (≈1.2 eV) subcell, which facilitates higher quasi-Fermi level splitting, reduces nonradiative recombination, alleviates hysteresis instabilities, and improves V oc to 0.84 V. Compositional engineering of large-bandgap (≈1.8 eV) perovskite is employed to realize a subcell with a transparent top electrode and photostabilized V oc of 1.22 V. The resultant monolithic perovskite-perovskite tandem solar cell shows a high V oc of 1.98 V (approaching 80% of the theoretical limit) and a stabilized PCE of 18.5%. The significantly minimized nonideal V oc,loss is better than state-of-the-art silicon-perovskite tandem solar cells, which highlights the prospects of using perovskite-perovskite tandems for solar-energy generation. It also unlocks opportunities for solar water splitting using hybrid perovskites with solar-to-hydrogen efficiencies beyond 15%. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. ICC Experiment Performance Improvement through Advanced Feedback Controllers for High-Power Low-Cost Switching Power Amplifiers

    International Nuclear Information System (INIS)

    Nelson, Brian A.

    2006-01-01

    Limited resources force most smaller fusion energy research experiments to have little or no feedback control of their operational parameters, preventing achievement of their full operational potential. Recent breakthroughs in high-power switching technologies have greatly reduced feedback-controlled power supply costs, primarily those classified as switching power amplifiers. However, inexpensive and flexible controllers for these power supplies have not been developed. A uClinux-based micro-controller (Analog Devices Blackfin BF537) was identified as having the capabilities to form the base of a digital control system for switching power amplifiers. A control algorithm was created, and a Linux character device driver was written to realize the algorithm. The software and algorithm were successfully tested on a switching power amplifier and magnetic field coil using University of Washington (subcontractor) resources

  2. A generic concept to overcome bandgap limitations for designing highly efficient multi-junction photovoltaic cells.

    Science.gov (United States)

    Guo, Fei; Li, Ning; Fecher, Frank W; Gasparini, Nicola; Ramirez Quiroz, Cesar Omar; Bronnbauer, Carina; Hou, Yi; Radmilović, Vuk V; Radmilović, Velimir R; Spiecker, Erdmann; Forberich, Karen; Brabec, Christoph J

    2015-07-16

    The multi-junction concept is the most relevant approach to overcome the Shockley-Queisser limit for single-junction photovoltaic cells. The record efficiencies of several types of solar technologies are held by series-connected tandem configurations. However, the stringent current-matching criterion presents primarily a material challenge and permanently requires developing and processing novel semiconductors with desired bandgaps and thicknesses. Here we report a generic concept to alleviate this limitation. By integrating series- and parallel-interconnections into a triple-junction configuration, we find significantly relaxed material selection and current-matching constraints. To illustrate the versatile applicability of the proposed triple-junction concept, organic and organic-inorganic hybrid triple-junction solar cells are constructed by printing methods. High fill factors up to 68% without resistive losses are achieved for both organic and hybrid triple-junction devices. Series/parallel triple-junction cells with organic, as well as perovskite-based subcells may become a key technology to further advance the efficiency roadmap of the existing photovoltaic technologies.

  3. Limitations to very high rate wire chambers in fixed target geometries

    International Nuclear Information System (INIS)

    Spiegel, L.

    1989-11-01

    The task is to explore physical limitations to the operation of wire chambers in fixed target geometries at an interaction rate of 52 MHz (chosen as it corresponds to the FNAL accelerator rf rate.) That is, to see if there are physical limitations to the operation of gaseous wire chambers at such a high operating rate. A primary proton beam energy of 800 GeV has been assumed although modest increases in the primary energy should not affect the basic conclusion as secondary multiplicity increases logarithmically with center-of-momentum energy. By sustaining a 52 MHz interaction rate it is meant that results from a given interaction are electronically isolated from preceding and subsequent rf buckets, good wire plane efficiency is maintained throughout the active region of the chamber, and the chamber operates in a stable manner throughout the course of a typical fixed target run -- six months to a full year. Other working assumptions include the understanding that chamber electronics -- amplifiers, discriminators, delay elements, encoders -- will not suffer degradation at 52 MHz and that the intensely populated beam regions have been somehow excluded from the chambers. 7 refs., 2 figs

  4. Chlorine-trapped CVD bilayer graphene for resistive pressure sensor with high detection limit and high sensitivity

    Science.gov (United States)

    Phuong Pham, Viet; Triet Nguyen, Minh; Park, Jin Woo; Kwak, Sung Soo; Nguyen, Dieu Hien Thi; Kyeom Mun, Mu; Danh Phan, Hoang; San Kim, Doo; Kim, Ki Hyun; Lee, Nae-Eung; Yeom, Geun Young

    2017-06-01

    Pressure sensing is one of the key functions for smart electronics. Considerably more effort is required to achieve the fabrication of pressure sensors that can imitate and overcome the sophisticated pressure sensing characteristics in nature and industry, especially in the innovation of materials and structures. Almost all of the pressure sensors reported until now have a high sensitivity at a low-pressure detection limit (type chlorine trap doping in the channel graphene with chlorine radicals without damaging the graphene. This work indicates that the ZGClG channel used for the pressure sensing device could also provide a simple and essential sensing platform for chemical-, medical-, and biological-sensing for future smart electronics.

  5. High-resolution surface analysis for extended-range downscaling with limited-area atmospheric models

    Science.gov (United States)

    Separovic, Leo; Husain, Syed Zahid; Yu, Wei; Fernig, David

    2014-12-01

    High-resolution limited-area model (LAM) simulations are frequently employed to downscale coarse-resolution objective analyses over a specified area of the globe using high-resolution computational grids. When LAMs are integrated over extended time frames, from months to years, they are prone to deviations in land surface variables that can be harmful to the quality of the simulated near-surface fields. Nudging of the prognostic surface fields toward a reference-gridded data set is therefore devised in order to prevent the atmospheric model from diverging from the expected values. This paper presents a method to generate high-resolution analyses of land-surface variables, such as surface canopy temperature, soil moisture, and snow conditions, to be used for the relaxation of lower boundary conditions in extended-range LAM simulations. The proposed method is based on performing offline simulations with an external surface model, forced with the near-surface meteorological fields derived from short-range forecast, operational analyses, and observed temperatures and humidity. Results show that the outputs of the surface model obtained in the present study have potential to improve the near-surface atmospheric fields in extended-range LAM integrations.

  6. On Limitations of the Ultrasonic Characterization of Pieces Manufactured with Highly Attenuating Materials

    Science.gov (United States)

    Ramos, A.; Moreno, E.; Rubio, B.; Calas, H.; Galarza, N.; Rubio, J.; Diez, L.; Castellanos, L.; Gómez, T.

    Some technical aspects of two Spanish cooperation projects, funded by DPI and Innpacto Programs of the R&D National Plan, are discussed. The objective is to analyze the common belief about than the ultrasonic testing in MHz range is not a tool utilizable to detect internal flaws in highly attenuating pieces made of coarse-grained steel. In fact high-strength steels, used in some safe industrial infrastructures of energy & transport sectors, are difficult to be inspected using the conventional "state of the art" in ultrasonic technology, due to their internal microstructures are very attenuating and coarse-grained. It is studied if this inspection difficulty could be overcome by finding intense interrogating pulses and advanced signal processing of the acquired echoes. A possible solution would depend on drastically improving signal-to-noise-ratios, by applying new advances on: ultrasonic transduction, HV electronics for intense pulsed driving of the testing probes, and an "ad-hoc" digital processing or focusing of the received noisy signals, in function of each material to be inspected. To attain this challenging aim on robust steel pieces would open the possibility of obtaining improvements in inspecting critical industrial components made of highly attenuating & dispersive materials, as new composites in aeronautic and motorway bridges, or new metallic alloys in nuclear area, where additional testing limitations often appear.

  7. Knockouts of high-ranking males have limited impact on baboon social networks.

    Science.gov (United States)

    Franz, Mathias; Altmann, Jeanne; Alberts, Susan C

    Social network structures can crucially impact complex social processes such as collective behaviour or the transmission of information and diseases. However, currently it is poorly understood how social networks change over time. Previous studies on primates suggest that `knockouts' (due to death or dispersal) of high-ranking individuals might be important drivers for structural changes in animal social networks. Here we test this hypothesis using long-term data on a natural population of baboons, examining the effects of 29 natural knockouts of alpha or beta males on adult female social networks. We investigated whether and how knockouts affected (1) changes in grooming and association rates among adult females, and (2) changes in mean degree and global clustering coefficient in these networks. The only significant effect that we found was a decrease in mean degree in grooming networks in the first month after knockouts, but this decrease was rather small, and grooming networks rebounded to baseline levels by the second month after knockouts. Taken together our results indicate that the removal of high-ranking males has only limited or no lasting effects on social networks of adult female baboons. This finding calls into question the hypothesis that the removal of high-ranking individuals has a destabilizing effect on social network structures in social animals.

  8. Definition and measurement of the times-diffraction-limit number of high-power laser beams

    Science.gov (United States)

    Bollanti, Sarah; Di Lazzaro, Paolo; Murra, Daniele

    1998-07-01

    A novel definition of the times-diffraction-limit (TDL) number of a laser beam is given. A comparison is made with the commonly used beam-propagation parameter M2, which is unreliable for hard-edge beams, like those produced by unstable resonators with diffraction output coupling. The new suggested TDL number definition doesn't rely on the real beam comparison to a Gaussian beam, but on the comparison of the far-field performances of the real beam with respect to those of a uniphase beam with the same amplitude profile in the near field. A practical method is also given for the estimation of the TDL number of real beams. Finally, this procedure is applied to the high-peak-power laser beams generated by two excimer laser systems developed in ENEA.

  9. Spot Size Limited Carbon Propellant Characterization for Efficient High Isp Laser Propulsion

    International Nuclear Information System (INIS)

    Uchida, Shigeaki; Shimada, Yoshinori; Hashimoto, Kazuhisa; Yamaura, Michiteru; Birou, Tomoya; Yoshida, Minoru

    2005-01-01

    Laser propulsion has very unique advantage of producing exhausting gas (ions) of very high velocity. Specific impulse from laser plasma could easily exceed 10,000 seconds that reduce the current propellant consumption rate on space born thrusters significantly. For efficient propellant usage, it is desirable that the exhaust plasma has rather narrow velocity distribution of fast ions. In order to accomplish the requirements, thermal conduction and neutral particle losses at and vicinity of the laser heated region have to be eliminated. A concept of spot size limited propellant shape has been proposed and tested in terms of the effects of the loss reduction. Ion and neutral particle measurements from laser plasmas produced on the above mentioned carbon targets are used to characterize the performance of the propellant

  10. Highly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerization

    KAUST Repository

    Fetsch, Corinna

    2012-06-05

    Advanced macromolecular engineering requires excellent control over the polymerization reaction. Living polymerization methods are notoriously sensitive to impurities, which makes a practical realization of such control very challenging. Reversible-deactivation radical polymerization methods are typically more robust, but have other limitations. Here, we demonstrate by repeated (ge;10 times) chain extension the extraordinary robustness of the living nucleophilic ring-opening polymerization of N-substituted glycine N-carboxyanhydrides, which yields polypeptoids. We observe essentially quantitative end-group fidelity under experimental conditions that are comparatively easily managed. This is employed to synthesize a pentablock quinquiespolymer with high definition. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Highly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerization

    KAUST Repository

    Fetsch, Corinna; Luxenhofer, Robert

    2012-01-01

    Advanced macromolecular engineering requires excellent control over the polymerization reaction. Living polymerization methods are notoriously sensitive to impurities, which makes a practical realization of such control very challenging. Reversible-deactivation radical polymerization methods are typically more robust, but have other limitations. Here, we demonstrate by repeated (ge;10 times) chain extension the extraordinary robustness of the living nucleophilic ring-opening polymerization of N-substituted glycine N-carboxyanhydrides, which yields polypeptoids. We observe essentially quantitative end-group fidelity under experimental conditions that are comparatively easily managed. This is employed to synthesize a pentablock quinquiespolymer with high definition. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Bandwidth Limitations in Characterization of High Intensity Focused Ultrasound Fields in the Presence of Shocks

    Science.gov (United States)

    Khokhlova, V. A.; Bessonova, O. V.; Soneson, J. E.; Canney, M. S.; Bailey, M. R.; Crum, L. A.

    2010-03-01

    Nonlinear propagation effects result in the formation of weak shocks in high intensity focused ultrasound (HIFU) fields. When shocks are present, the wave spectrum consists of hundreds of harmonics. In practice, shock waves are modeled using a finite number of harmonics and measured with hydrophones that have limited bandwidths. The goal of this work was to determine how many harmonics are necessary to model or measure peak pressures, intensity, and heat deposition rates of the HIFU fields. Numerical solutions of the Khokhlov-Zabolotskaya-Kuznetzov-type (KZK) nonlinear parabolic equation were obtained using two independent algorithms, compared, and analyzed for nonlinear propagation in water, in gel phantom, and in tissue. Measurements were performed in the focus of the HIFU field in the same media using fiber optic probe hydrophones of various bandwidths. Experimental data were compared to the simulation results.

  13. Weight Loss at a Cost: Implications of High-Protein, Low- Carbohydrate Diets.

    Science.gov (United States)

    Gabel, Kathe A.; Lund, Robin J.

    2002-01-01

    Addresses three claims of high-protein, low-carbohydrate diets: weight loss is attributed to the composition of the diet; insulin promotes the storage of fat, thereby, by limiting carbohydrates, dieters will decrease levels of insulin and body fat; and weight loss is the result of fat loss. The paper examines relevant scientific reports and notes…

  14. Critical parameters in cost-effective alkaline extraction for high protein yield from leaves

    NARCIS (Netherlands)

    Zhang, C.; Sanders, J.P.M.; Bruins, M.E.

    2014-01-01

    Leaves are potential resources for feed or food, but their applications are limited due to a high proportion of insoluble protein and inefficient processing. To overcome these problems, parameters of alkaline extraction were evaluated using green tea residue (GTR). Protein extraction could be

  15. Inkjet printing of novel wideband and high gain antennas on low-cost paper substrate

    KAUST Repository

    Cook, Benjamin Stassen

    2012-09-01

    A complete characterization of the inkjet printing process using metallic nanoparticle inks on a paper substrate for microwave frequencies up to 12.5 GHz as well as its application to low-cost, high gain and wideband antenna design are demonstrated in this work. Laser and heat sintering of metallic nanoparticles are compared on paper substrate for the first time which demonstrate immense cost and time benefits of laser sintering. The antennas fabricated using the characterized process include a Vivaldi for the UWB band which exhibits a significantly higher gain of up to 8 dBi as compared to the currently published inkjet printed antennas, and a novel slow-wave log periodic dipole array which employs a new miniaturization technique to show 20% width reduction. © 1963-2012 IEEE.

  16. Locating operations in high labor cost countries – Evidence from Spain

    Directory of Open Access Journals (Sweden)

    Angel Diaz

    2017-06-01

    Full Text Available The location of operations in high labor cost countries is increasingly discussed in the media, in part for recent declarations and actions from the president of USA, Donald Trump. While this particular instance can be labeled as populist or protectionist, the factors underlying the debate are extremely important: advances in systematic increases in productivity, low population growth, and the transfer of jobs to countries with lower labor costs are creating unemployment and underemployment in developed countries that could eventually result in protectionism and restrictions to free trade. This phenomenon has enormous social and economic implications, and has attracted considerable interest from researchers. In particular, this study provides empirical evidence of the location of manufacturing and services in the context of a European country (Spain, exploring the drivers, social implications and organizational theories that can explain it.

  17. Designing HIGH-COST medicine: hospital surveys, health planning, and the paradox of progressive reform.

    Science.gov (United States)

    Perkins, Barbara Bridgman

    2010-02-01

    Inspired by social medicine, some progressive US health reforms have paradoxically reinforced a business model of high-cost medical delivery that does not match social needs. In analyzing the financial status of their areas' hospitals, for example, city-wide hospital surveys of the 1910s through 1930s sought to direct capital investments and, in so doing, control competition and markets. The 2 national health planning programs that ran from the mid-1960s to the mid-1980s continued similar strategies of economic organization and management, as did the so-called market reforms that followed. Consequently, these reforms promoted large, extremely specialized, capital-intensive institutions and systems at the expense of less complex (and less costly) primary and chronic care. The current capital crisis may expose the lack of sustainability of such a model and open up new ideas and new ways to build health care designed to meet people's health needs.

  18. Characteristics and healthcare utilisation patterns of high-cost beneficiaries in the Netherlands: a cross-sectional claims database study

    NARCIS (Netherlands)

    Wammes, J.J.G.; Tanke, M.A.C.; Jonkers, W.; Westert, G.P.; Wees, P.J. van der; Jeurissen, P.P.T.

    2017-01-01

    OBJECTIVE: To determine medical needs, demographic characteristics and healthcare utilisation patterns of the top 1% and top 2%-5% high-cost beneficiaries in the Netherlands. DESIGN: Cross-sectional study using 1 year claims data. We broke down high-cost beneficiaries by demographics, the most

  19. 76 FR 60031 - Notice of Order: Revisions to Enterprise Public Use Database Incorporating High-Cost Single...

    Science.gov (United States)

    2011-09-28

    ... single-family matrix in FHFA's Public Use Database (PUDB) to include data fields for the high-cost single... Use Database Incorporating High-Cost Single-Family Securitized Loan Data Fields and Technical Data... amended, it is necessary to revise the single-family matrix of FHFA's Public Use Database (PUDB) by adding...

  20. The High Cost of Failing to Reform Public Education in Indiana. School Choice Issues in the State

    Science.gov (United States)

    Gottlob, Brian J.

    2006-01-01

    This study documents the public costs of high school dropouts in Indiana, and examines how school choice would provide large public benefits by increasing the graduation rate in Indiana public schools. It calculates the annual cost of high school dropouts in Indiana due to lower state income tax payments, increased reliance on Medicaid, and…

  1. Lessons Learned in the Update of a Safety Limit for the High Flux Isotope Reactor

    International Nuclear Information System (INIS)

    Cook, David Howard

    2009-01-01

    A recent unreviewed safety question (USQ) regarding a portion of the High Flux Isotope Reactor (HFIR) transient decay heat removal analysis focused on applicability of a heat transfer correlation at the low flow end of reactor operations. During resolution of this issue, review of the correlations used to establish the safety limit (SL) on reactor flux-to-flow ratio revealed the need to change the magnitude of the SL at the low flow end of reactor operations and the need to update the hot spot fuel damage criteria to incorporate current knowledge involving parallel channel flow stability. Because of the original safety design strategy for the reactor, resolution of the issues for the flux-to-flow ratio involved reevaluation of all key process variable SLs and limiting control settings (LCSs) using the current version of the heat transfer analysis code for the reactor. Goals of the work involved updating and upgrading the SL analysis where necessary, while preserving the safety design strategy for the reactor. Changes made include revisions to the safety design criteria at low flows to address the USQ, update of the process- and analysis input-variable uncertainty considerations, and upgrade of the safety design criteria at high flow. The challenges faced during update/upgrade of this SL and LCS are typical of the problems found in the integration of safety into the design process for a complex facility. In particular, the problems addressed in the area of instrument uncertainties provide valuable lessons learned for establishment and configuration control of SLs for large facilities

  2. Limited efficacy of the ketogenic diet in the treatment of highly refractory epileptic spasms.

    Science.gov (United States)

    Hussain, Shaun A; Shin, Ji Hyun; Shih, Evan J; Murata, Kristina K; Sewak, Sarika; Kezele, Michele E; Sankar, Raman; Matsumoto, Joyce H

    2016-02-01

    Numerous studies have suggested that the ketogenic diet is effective in the treatment of epileptic spasms, even in refractory cases. However, there has been very limited demonstration of prompt and complete (video-EEG confirmed) response. We set out to describe our center's experience with the ketogenic diet in the treatment of children with highly refractory epileptic spasms, with rigorous seizure outcome assessment. Children treated with the ketogenic diet for epileptic spasms between April, 2010 and June, 2014 were retrospectively identified. Seizure burden was tabulated at baseline and after 1, 3, 6, and 12-months of ketogenic diet exposure. Adverse events were similarly ascertained. We identified a cohort of 22 consecutive patients who received ketogenic diet therapy, with median age of onset of epileptic spasms of 5.2 (IQR 2.0-9.0) months, with diet initiation beginning a median of 26.4 (12.5-38.7) months after onset, and following a median of 7 (IQR 5-7) treatment failures. Only 2 patients exhibited a complete response during ketogenic diet exposure, and response was more reasonably attributed to alternative therapies in both cases. A modest early reduction in seizure frequency was not sustained beyond 1 month of diet exposure. The diet was well tolerated, and continued in 6 patients with subjective and/or partial response. In contrast to prior studies reporting substantial efficacy of the ketogenic diet, our findings suggest limited efficacy, albeit in a highly refractory cohort. Prospective studies in both refractory and new-onset populations, with both video-EEG confirmation of response and rigorous cognitive outcome assessment, would be of great value to more clearly define the utility of the ketogenic diet in the treatment of epileptic spasms. Copyright © 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  3. Gluten-Free Foods in Rural Maritime Provinces: Limited Availability, High Price, and Low Iron Content.

    Science.gov (United States)

    Jamieson, Jennifer A; Gougeon, Laura

    2017-12-01

    We investigated the price difference between gluten-free (GF) and gluten-containing (GC) foods available in rural Maritime stores. GF foods and comparable GC items were sampled through random visits to 21 grocery stores in nonurban areas of Nova Scotia, New Brunswick, and Prince Edward Island, Canada. Wilcoxon rank tests were conducted on price per 100 g of product, and on the price relative to iron content; 2226 GF foods (27.2% staple items, defined as breads, cereals, flours, and pastas) and 1625 GC foods were sampled, with an average ± SD of 66 ± 2.7 GF items per store in rural areas and 331 ± 12 in towns. The median price of GF items ($1.76/100 g) was more expensive than GC counterparts ($1.05/100 g) and iron density was approximately 50% less. GF staple foods were priced 5% higher in rural stores than in town stores. Although the variety of GF products available to consumers has improved, higher cost and lower nutrient density remain issues in nonurban Maritime regions. Dietitians working in nonurban areas should consider the relative high price, difficult access, and low iron density of key GF items, and work together with clients to find alternatives and enhance their food literacy.

  4. Uncovering behavioural diversity amongst high-strength Pseudomonas spp. surfactants at the limit of liquid surface tension reduction.

    Science.gov (United States)

    Kabir, Kamaluddeen; Deeni, Yusuf Y; Hapca, Simona M; Moore, Luke; Spiers, Andrew J

    2018-02-01

    Bacterial biosurfactants have a wide range of biological functions and biotechnological applications. Previous analyses had suggested a limit to their reduction of aqueous liquid surface tensions (γMin), and here we confirm this in an analysis of 25 Pseudomonas spp. strains isolated from soil which produce high-strength surfactants that reduce surface tensions to 25.2 ± 0.1-26.5 ± 0.2 mN m-1 (the surface tension of sterile growth medium and pure water was 52.9 ± 0.4 mN m-1 and 72.1 ± 1.2 mN m-1, respectively). Comparisons of culture supernatants produced using different growth media and semi-purified samples indicate that the limit of 24.2-24.7 mN m-1 is not greatly influenced by culture conditions, pH or NaCl concentrations. We have used foam, emulsion and oil-displacement behavioural assays as a simple and cost-effective proxy for in-depth biochemical characterisation, and these suggest that there is significant structural diversity amongst these surfactants that may reflect different biological functions and offer new biotechnological opportunities. Finally, we obtained a draft genome for the strain producing the highest strength surfactant, and identified a cluster of non-ribosomal protein synthase genes that may produce a cyclic lipopeptide (CLP)-like surfactant. Further investigation of this group of related bacteria recovered from the same site will allow a better understanding of the significance of the great variety of surfactants produced by bacterial communities found in soil and elsewhere. © FEMS 2018. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. Accuracy and cost-analysis of placental alpha-microglobulin-1 test in the diagnosis of premature rupture of fetal membranes in resource-limited community settings.

    Science.gov (United States)

    Eleje, George Uchenna; Ezugwu, Euzebus Chinonye; Ogunyemi, Dotun; Eleje, Lydia Ijeoma; Ikechebelu, Joseph Ifeanyichukwu; Igwegbe, Anthony Osita; Okonkwo, John E; Ikpeze, Okechukwu Christian; Udigwe, Gerald Okanandu; Onah, Hyacinth Eze; Nwosu, Betrand Obi; Ezeama, Chukwuemeka Okwudili; Ezenkwele, Eziamaka Pauline

    2015-01-01

    To determine accuracy and costs of placental α-microglobulin-1 (PAMG-1) test compared to standard clinical assessment (SCA) for diagnosing rupture of membranes (ROM). A multicenter double-blind study of consecutive women with symptoms and signs of ROM in Nnamdi Azikiwe University Teaching Hospital, Nnewi and University of Nigeria Teaching Hospital, Enugu, both in south-east Nigeria using SCA for ROM and the PAMG-1 test was done. ROM was diagnosed if two out of three methods from SCA (pooling, positive nitrazine test or ferning) were present and confirmed post-delivery based on presence of any two of these clinical criteria: delivery in 48 h to 7 days, evidence of chorioamnionitis, membranes overtly ruptured at delivery and adverse perinatal outcomes strongly correlated with prolonged PROM. A cost-analysis was also done. The outcome measures included sensitivity, specificity, accuracy and costs for the two tests. Accuracy, sensitivity and specificity for the PAMG-1 test were 97.2%, 97.4% and 96.7%, higher than for SCA which were 83.7%, 87.9% and 70.5%, respectively (P < 0.001). Accuracy of SCA was higher at less than 34 weeks than 34 weeks or more (88.3% vs 81.4%) while the PAMG-1 test performed equally at both gestational age categories (96.1% vs 97.7%). In women without pooling, accuracy of the PAMG-1 test was 96.7%, while it was 40.0% with SCA. Analysis showed that the overall cost of SCA was 45% higher than the PAMG-1 test. This study confirms that the PAMG-1 test has a consistently high diagnostic accuracy at all gestational ages and with equivocal cases of ROM. The PAMG-1 test appears less costly than SCA. © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.

  6. The high-ion content and kinematics of low-redshift Lyman limit systems

    International Nuclear Information System (INIS)

    Fox, Andrew J.; Tumlinson, Jason; Bordoloi, Rongmon; Lehner, Nicolas; Howk, J. Christopher; Tripp, Todd M.; Katz, Neal; Prochaska, J. Xavier; Werk, Jessica K.; O'Meara, John M.; Oppenheimer, Benjamin D.; Davé, Romeel

    2013-01-01

    We study the high-ion content and kinematics of the circumgalactic medium around low-redshift galaxies using a sample of 23 Lyman limit systems (LLSs) at 0.08 < z < 0.93 observed with the Cosmic Origins Spectrograph on board the Hubble Space Telescope. In Lehner et al., we recently showed that low-z LLSs have a bimodal metallicity distribution. Here we extend that analysis to search for differences between the high-ion and kinematic properties of the metal-poor and metal-rich branches. We find that metal-rich LLSs tend to show higher O VI columns and broader O VI profiles than metal-poor LLSs. The total H I line width (Δv 90 statistic) in LLSs is not correlated with metallicity, indicating that the H I kinematics alone cannot be used to distinguish inflow from outflow and gas recycling. Among the 17 LLSs with O VI detections, all but two show evidence of kinematic sub-structure, in the form of O VI-H I centroid offsets, multiple components, or both. Using various scenarios for how the metallicities in the high-ion and low-ion phases of each LLS compare, we constrain the ionized hydrogen column in the O VI phase to lie in the range log N(H II) ∼ 17.6-20. The O VI phase of LLSs is a substantial baryon reservoir, with M(high-ion) ∼ 10 8.5-10.9 (r/150 kpc) 2 M ☉ , similar to the mass in the low-ion phase. Accounting for the O VI phase approximately doubles the contribution of low-z LLSs to the cosmic baryon budget.

  7. The high-ion content and kinematics of low-redshift Lyman limit systems

    Energy Technology Data Exchange (ETDEWEB)

    Fox, Andrew J.; Tumlinson, Jason; Bordoloi, Rongmon [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Lehner, Nicolas; Howk, J. Christopher [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Tripp, Todd M.; Katz, Neal [Department of Astronomy, University of Massachusetts, Amherst, MA 01003 (United States); Prochaska, J. Xavier; Werk, Jessica K. [UCO/Lick Observatory, University of California, Santa Cruz, CA 95064 (United States); O' Meara, John M. [Department of Physics, Saint Michael' s College, One Winooski Park, Colchester, VT 05439 (United States); Oppenheimer, Benjamin D. [Leiden Observatory, Leiden University, NL-2300 RA Leiden (Netherlands); Davé, Romeel, E-mail: afox@stsci.edu [University of the Western Cape, Robert Sobukwe Road, Bellville 7535 (South Africa)

    2013-12-01

    We study the high-ion content and kinematics of the circumgalactic medium around low-redshift galaxies using a sample of 23 Lyman limit systems (LLSs) at 0.08 < z < 0.93 observed with the Cosmic Origins Spectrograph on board the Hubble Space Telescope. In Lehner et al., we recently showed that low-z LLSs have a bimodal metallicity distribution. Here we extend that analysis to search for differences between the high-ion and kinematic properties of the metal-poor and metal-rich branches. We find that metal-rich LLSs tend to show higher O VI columns and broader O VI profiles than metal-poor LLSs. The total H I line width (Δv {sub 90} statistic) in LLSs is not correlated with metallicity, indicating that the H I kinematics alone cannot be used to distinguish inflow from outflow and gas recycling. Among the 17 LLSs with O VI detections, all but two show evidence of kinematic sub-structure, in the form of O VI-H I centroid offsets, multiple components, or both. Using various scenarios for how the metallicities in the high-ion and low-ion phases of each LLS compare, we constrain the ionized hydrogen column in the O VI phase to lie in the range log N(H II) ∼ 17.6-20. The O VI phase of LLSs is a substantial baryon reservoir, with M(high-ion) ∼ 10{sup 8.5-10.9} (r/150 kpc){sup 2} M {sub ☉}, similar to the mass in the low-ion phase. Accounting for the O VI phase approximately doubles the contribution of low-z LLSs to the cosmic baryon budget.

  8. Cost of illness for cholera in a high risk urban area in Bangladesh: an analysis from household perspective

    Science.gov (United States)

    2013-01-01

    Background Cholera poses a substantial health burden to developing countries such as Bangladesh. In this study, the objective is to estimate the economic burden of cholera treatments incurred by households. The study was carried out in the context of a large vaccine trial in an urban area of Bangladesh. Methods The study used a combination of prospective and retrospective incidence-based cost analyses of cholera illness per episode per household. A total of 394 confirmed cholera hospitalized cases were identified and treated in the study area during June–October 2011. Households with cholera patients were interviewed within 15 days after discharge from hospitals or clinics. To estimate the total cost of cholera illness a structured questionnaire was used, which included questions on direct medical costs, non-medical costs, and the indirect costs of patients and caregivers. Results The average total household cost of treatment for an episode of cholera was US$30.40. Total direct and indirect costs constituted 24.6% (US$7.40) and 75.4% (US$23.00) of the average total cost, respectively. The cost for children under 5 years of age (US$21.50) was higher than that of children aged 5–14 years (US$17.50). The direct cost of treatment was similar for male and female patients, but the indirect cost was higher for males. Conclusion Our study suggests that by preventing one cholera episode (3 days on an average), we can avert a total cost of 2,278.50 BDT (US$30.40) per household. Among medical components, medicines are the largest cost driver. No clear socioeconomic gradient emerged from our study, but limited demographic patterns were observed in the cost of illness. By preventing cholera cases, large production losses can be reduced. PMID:24188717

  9. The cost of empathy: Parent-adolescent conflict predicts emotion dysregulation for highly empathic youth.

    Science.gov (United States)

    Van Lissa, Caspar J; Hawk, Skyler T; Koot, Hans M; Branje, Susan; Meeus, Wim H J

    2017-09-01

    Empathy plays a key role in maintaining close relationships and promoting prosocial conflict resolution. However, research has not addressed the potential emotional cost of adolescents' high empathy, particularly when relationships are characterized by more frequent conflict. The present 6-year longitudinal study (N = 467) investigated whether conflict with parents predicted emotion dysregulation more strongly for high-empathy adolescents than for lower-empathy adolescents. Emotion dysregulation was operationalized at both the experiential level, using mood diary data collected for 3 weeks each year, and at the dispositional level, using annual self-report measures. In line with predictions, we found that more frequent adolescent-parent conflict predicted greater day-to-day mood variability and dispositional difficulties in emotion regulation for high-empathy adolescents, but not for average- and low-empathy adolescents. Mood variability and difficulties in emotion regulation, in turn, also predicted increased conflict with parents. These links were not moderated by empathy. Moreover, our research allowed for a novel investigation of the interplay between experiential and dispositional emotion dysregulation. Day-to-day mood variability predicted increasing dispositional difficulties in emotion regulation over time, which suggests that experiential dysregulation becomes consolidated into dispositional difficulties in emotion regulation. Moderated mediation analyses revealed that, for high-empathy adolescents, conflict was a driver of this dysregulation consolidation process. Finally, emotion dysregulation played a role in overtime conflict maintenance for high-empathy adolescents. This suggests that, through emotion dysregulation, high empathy may paradoxically also contribute to maintaining negative adolescent-parent interactions. Our research indicates that high empathy comes at a cost when adolescent-parent relationships are characterized by greater negativity

  10. The psychological costs and benefits of being highly persistent: personality profiles distinguish mood disorders from anxiety disorders.

    Science.gov (United States)

    Cloninger, C Robert; Zohar, Ada H; Hirschmann, Schmuel; Dahan, Dana

    2012-02-01

    The personality trait of Persistence is highly valued by conscientious overachievers, but it has both psychological costs and benefits. The interactions among multiple personality factors influencing the development of mood and anxiety disorders have been confounded in prior clinical samples, but can be disentangled in terms of their underlying brain circuitry and influence on perception of emotional stimuli. 285 individuals who represented the full range of personality variation in a large sample of adult volunteers from the general community of Israel were selected for follow-up by psychiatric interviews, cognitive testing, and medical examinations. The Temperament and Character Inventory (TCI) measured profiles of traits that distinguished individuals with diagnoses of mood and/or anxiety disorders using linear discriminant analysis and non-linear profile analysis. High Harm Avoidance and low Self-directedness strongly distinguished people with mood and/or anxiety disorders from those with neither. High Persistence distinguished people with only anxiety disorders from those with mood disorders. High Persistence was associated with greater health and happiness overall, but also led to more negative emotions than in people with low Persistence unless they were both unusually tolerant of frustration (i.e., low in Harm Avoidance) and self-accepting of personal limitations (i.e. high in Self-directedness). Subjects were volunteers over 40 years of age at assessment. People who are highly persistent (i.e., persevering, ambitious, perfectionistic) are more likely to have anxiety disorders than mood disorders, even when they have other traits increasing risk for both (i.e., high Harm Avoidance and low Self-directedness). High Persistence increases both positive and negative emotions in most people. However, high Persistence reduces negative emotions and increases positive emotions if a person is easy-going (i.e., "happy-go-lucky" when low in both Harm Avoidance and Self

  11. High aspect ratio problem in simulation of a fault current limiter based on superconducting tapes

    International Nuclear Information System (INIS)

    Velichko, A V; Coombs, T A

    2006-01-01

    We are offering a solution for the high-aspect-ratio problem relevant to the numerical simulation of AC loss in superconductors and metals with high aspect (width-to-thickness) ratio. This is particularly relevant to simulation of fault current limiters (FCLs) based on second generation YBCO tapes on RABiTS. By assuming a linear scaling of the electric and thermal properties with the size of the structure, we can replace the real sample with an effective sample of a reduced aspect ratio by introducing size multipliers into the equations that govern the physics of the system. The simulation is performed using both a proprietary equivalent circuit software and a commercial FEM software. The correctness of the procedure is verified by simulating temperature and current distributions for samples with all three dimensions varying within 10 -3 -10 3 of the original size. Qualitatively the distributions for the original and scaled samples are indistinguishable, whereas quantitative differences in the worst case do not exceed 10%

  12. High aspect ratio problem in simulation of a fault current limiter based on superconducting tapes

    Energy Technology Data Exchange (ETDEWEB)

    Velichko, A V; Coombs, T A [Electrical Engineering Division, University of Cambridge (United Kingdom)

    2006-06-15

    We are offering a solution for the high-aspect-ratio problem relevant to the numerical simulation of AC loss in superconductors and metals with high aspect (width-to-thickness) ratio. This is particularly relevant to simulation of fault current limiters (FCLs) based on second generation YBCO tapes on RABiTS. By assuming a linear scaling of the electric and thermal properties with the size of the structure, we can replace the real sample with an effective sample of a reduced aspect ratio by introducing size multipliers into the equations that govern the physics of the system. The simulation is performed using both a proprietary equivalent circuit software and a commercial FEM software. The correctness of the procedure is verified by simulating temperature and current distributions for samples with all three dimensions varying within 10{sup -3}-10{sup 3} of the original size. Qualitatively the distributions for the original and scaled samples are indistinguishable, whereas quantitative differences in the worst case do not exceed 10%.

  13. High-energy limit of collision-induced false vacuum decay

    Energy Technology Data Exchange (ETDEWEB)

    Demidov, Sergei; Levkov, Dmitry [Institute for Nuclear Research of the Russian Academy of Sciences,60-th October Anniversary Prospect 7a, Moscow, 117312 (Russian Federation)

    2015-06-17

    We develop a consistent semiclassical description of field-theoretic collision-induced tunneling at arbitrary high collision energies. As a playground we consider a (1+1)-dimensional false vacuum decay initiated by a collision of N particles at energy E, paying special attention to the realistic case of N=2 particles. We demonstrate that the cross section of this process is exponentially suppressed at all energies. Moreover, the respective suppressesion exponent F{sub N}(E) exhibits a specific behavior which is significant for our semiclassical method and assumed to be general: it decreases with energy, reaches absolute minimum F=F{sub min}(N) at a certain threshold energy E=E{sub rt}(N), and stays constant at higher energies. We show that the minimal suppression F{sub min}(N) and threshold energy can be evaluated using a special class of semiclassical solutions which describe exponentially suppressed transitions but nevertheless evolve in real time. Importantly, we argue that the cross section at energies above E{sub rt}(N) is computed perturbatively in the background of the latter solutions, and the terms of this perturbative expansion stay bounded in the infinite-energy limit. Transitions in the high-energy regime proceed via emission of many soft quanta with total energy E{sub rt}; the energy excess E−E{sub rt} remains in the colliding particles till the end of the process.

  14. The cost-effectiveness and cost-utility of high-dose palliative radiotherapy for advanced non-small-cell lung cancer

    International Nuclear Information System (INIS)

    Coy, Peter; Schaafsma, Joseph; Schofield, John A.

    2000-01-01

    Purpose: To compute cost-effectiveness/cost-utility (CE/CU) ratios, from the treatment clinic and societal perspectives, for high-dose palliative radiotherapy treatment (RT) for advanced non-small-cell lung cancer (NSCLC) against best supportive care (BSC) as comparator, and thereby demonstrate a method for computing CE/CU ratios when randomized clinical trial (RCT) data cannot be generated. Methods and Materials: Unit cost estimates based on an earlier reported 1989-90 analysis of treatment costs at the Vancouver Island Cancer Centre, Victoria, British Columbia, Canada, are updated to 1997-1998 and then used to compute the incremental cost of an average dose of high-dose palliative RT. The incremental number of life days and quality-adjusted life days (QALDs) attributable to treatment are from earlier reported regression analyses of the survival and quality-of-life data from patients who enrolled prospectively in a lung cancer management cost-effectiveness study at the clinic over a 2-year period from 1990 to 1992. Results: The baseline CE and CU ratios are $9245 Cdn per life year (LY) and $12,836 per quality-adjusted life year (QALY), respectively, from the clinic perspective; and $12,253/LY and $17,012/QALY, respectively, from the societal perspective. Multivariate sensitivity analysis for the CE ratio produces a range of $5513-28,270/LY from the clinic perspective, and $7307-37,465/LY from the societal perspective. Similar calculations for the CU ratio produce a range of $7205-37,134/QALY from the clinic perspective, and $9550-49,213/QALY from the societal perspective. Conclusion: The cost effectiveness and cost utility of high-dose palliative RT for advanced NSCLC compares favorably with the cost effectiveness of other forms of treatment for NSCLC, of treatments of other forms of cancer, and of many other commonly used medical interventions; and lies within the US $50,000/QALY benchmark often cited for cost-effective care

  15. Pole lengths influence O2-cost during double poling in highly trained cross-country skiers.

    Science.gov (United States)

    Carlsen, Camilla Høivik; Rud, Bjarne; Myklebust, Håvard; Losnegard, Thomas

    2018-02-01

    In elite cross-country skiing, double poling is used in different terrain. This study compared O 2 -cost and kinematics during double poling with four different pole lengths [self-selected (SS), SS - 5 cm, SS + 5 cm, SS + 10 cm] at Low versus Moderate incline. Thirteen highly trained male cross-country skiers (mean ± SD 23 ± 3 years; 182 ± 4 cm; 77 ± 6 kg) completed eight submaximal trials with roller skis on a treadmill at two conditions: "Low incline" (1.7°; 4.5 m s -1 ) and "Moderate incline" (4.5°; 2.5 m s -1 ) with each of the four pole lengths. O 2 -cost and 3D body kinematics were assessed in each trial. In Low incline, SS + 10 cm induced a lower O 2 -cost than all the other pole lengths [P size (ES) 0.5-0.8], whereas no differences were found between the remaining pole lengths (P > 0.05; ES 0.2-0.4). In Moderate incline, significant differences between all pole lengths were found for O 2 -cost, with SS - 5 cm > SS > SS + 5 cm > SS + 10 cm (P differences in O 2 -cost between SS and the other pole lengths were greater in Moderate incline than Low incline (SS - 5 cm; 1.5%, ES 0.8, SS + 5 cm; 1.3%, ES 1.0, and SS + 10 cm; 1.9%, ES 1.0, all P difference was found in cycle, poling or reposition times between pole lengths. However, at both conditions a smaller total vertical displacement of center of mass was observed with SS + 10 cm compared to the other pole lengths. Increasing pole length from SS - 5 cm to SS + 10 cm during double poling induced lower O 2 -cost and this advantage was greater in Moderate compared to Low incline.

  16. Expected cost effectiveness of high-dose trivalent influenza vaccine in US seniors.

    Science.gov (United States)

    Chit, Ayman; Roiz, Julie; Briquet, Benjamin; Greenberg, David P

    2015-01-29

    Seniors are particularly vulnerable to complications resulting from influenza infection. Numerous influenza vaccines are available to immunize US seniors, and practitioners must decide which product to use. Options include trivalent and quadrivalent standard-dose inactivated influenza vaccines (IIV3 and IIV4 respectively), as well as a high-dose IIV3 (HD). Our research examines the public health impact, budget impact, and cost-utility of HD versus IIV3 and IIV4 for immunization of US seniors 65 years of age and older. Our model was based on US influenza-related health outcome data. Health care costs and vaccine prices were obtained from the Centers for Medicare and Medicaid Services. Efficacies of IIV3 and IIV4 were estimated from various meta-analyses of IIV3 efficacy. The results of a head-to-head randomized controlled trial of HD vs. IIV3 were used to estimate relative efficacy of HD. Conservatively, herd protection was not considered. Compared to IIV3, HD would avert 195,958 cases of influenza, 22,567 influenza-related hospitalizations, and 5423 influenza-related deaths among US seniors. HD generates 29,023 more Quality Adjusted Life Years (QALYs) and a net societal budget impact of $154 million. The Incremental Cost Effectiveness Ratio (ICER) for this comparison is $5299/QALY. 71% of the probabilistic sensitivity analysis (PSA) simulations were seniors. Our conclusions were robust in the face of sensitivity analyses. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  17. Balancing forest-regeneration probabilities and maintenance costs in dry grasslands of high conservation priority

    Science.gov (United States)

    Bolliger, Janine; Edwards, Thomas C.; Eggenberg, Stefan; Ismail, Sascha; Seidl, Irmi; Kienast, Felix

    2011-01-01

    Abandonment of agricultural land has resulted in forest regeneration in species-rich dry grasslands across European mountain regions and threatens conservation efforts in this vegetation type. To support national conservation strategies, we used a site-selection algorithm (MARXAN) to find optimum sets of floristic regions (reporting units) that contain grasslands of high conservation priority. We sought optimum sets that would accommodate 136 important dry-grassland species and that would minimize forest regeneration and costs of management needed to forestall predicted forest regeneration. We did not consider other conservation elements of dry grasslands, such as animal species richness, cultural heritage, and changes due to climate change. Optimal sets that included 95–100% of the dry grassland species encompassed an average of 56–59 floristic regions (standard deviation, SD 5). This is about 15% of approximately 400 floristic regions that contain dry-grassland sites and translates to 4800–5300 ha of dry grassland out of a total of approximately 23,000 ha for the entire study area. Projected costs to manage the grasslands in these optimum sets ranged from CHF (Swiss francs) 5.2 to 6.0 million/year. This is only 15–20% of the current total estimated cost of approximately CHF30–45 million/year required if all dry grasslands were to be protected. The grasslands of the optimal sets may be viewed as core sites in a national conservation strategy.

  18. FlexSAR, a high quality, flexible, cost effective, prototype SAR system

    Science.gov (United States)

    Jensen, Mark; Knight, Chad; Haslem, Brent

    2016-05-01

    The FlexSAR radar system was designed to be a high quality, low-cost, flexible research prototype instrument. Radar researchers and practitioners often desire the ability to prototype new or advanced configurations, yet the ability to enhance or upgrade existing radar systems can be cost prohibitive. FlexSAR answers the need for a flexible radar system that can be extended easily, with minimal cost and time expenditures. The design approach focuses on reducing the resources required for developing and validating new advanced radar modalities. Such an approach fosters innovation and provides risk reduction since actual radar data can be collected in the appropriate mode, processed, and analyzed early in the development process. This allows for an accurate, detailed understanding of the corresponding trade space. This paper is a follow-on to last years paper and discusses the advancements that have been made to the FlexSAR system. The overall system architecture is discussed and presented along with several examples illustrating the system utility.

  19. Cost-Benefit Analysis of High-Speed Rail Link between Hong Kong and Mainland China

    Directory of Open Access Journals (Sweden)

    R. Tao

    2011-07-01

    Full Text Available The Legislative Council in Hong Kong has approved a funding of USD$8.60 billion to build the high-speed rail (HSR line linking mainland China. HSR is a break-through technology that allows trains running at a speed over 250 km per hour. The most controversial part of the HSR investment is whether its cost could be compensated by the social benefits. In this study, a cost-benefit analysis of the Hong Kong to mainland HSR (HKM-HSR line is carried out. First, all the direct and indirect costs, and social benefits are defined; then, monetary equivalents are assigned to these elements; third, all the future values are discounted into present values and aggregated. The results show that the project has a positive net present value (NPV up to USD$2,068.49 million, which proves that the investment is worth. In addition, other transport alternatives, i.e. the existing roadway and conventional railway, are examined and compared with HKM-HSR, which unveils that HSR has the largest positive NPV among these three passenger transportation modes because of its excellent performance in ticket revenue, travel time savings and safety improvement.

  20. Hydrostatic limits of Fluorinert liquids used for neutron and transport studies at high pressure

    International Nuclear Information System (INIS)

    Sidorov, V A; Sadykov, R A

    2005-01-01

    We determined the hydrostatic limits at room temperature for a number of Fluorinert liquids: FC70, FC75, FC77, FC84, FC87 and their mixtures. Pressure exceeding this limit produces pressure gradients in the sample, which are retained at low temperature. The maximum hydrostatic limit (2.3 GPa) was found for a (1:1) mixture of FC84/87