WorldWideScience

Sample records for high convergent validity

  1. Convergent Validity of the PUTS

    Directory of Open Access Journals (Sweden)

    Valerie Cathérine Brandt

    2016-04-01

    Full Text Available Premonitory urges are a cardinal feature in Gilles de la Tourette syndrome. Severity of premonitory urges can be assessed with the Premonitory Urge for Tic Disorders Scale (PUTS. However, convergent validity of the measure has been difficult to assess due to the lack of other urge measures.We investigated the relationship between average real-time urge intensity assessed by an in-house developed real-time urge monitor, measuring urge intensity continuously for 5mins on a visual analogue scale, and general urge intensity assessed by the PUTS in 22 adult Tourette patients (mean age 29.8+/- 10.3; 19 male. Additionally, underlying factors of premonitory urges assessed by the PUTS were investigated in the adult sample using factor analysis and were replicated in 40 children and adolescents diagnosed with Tourette syndrome (mean age 12.05 +/- 2.83 SD, 31 male.Cronbach’s alpha for the PUTS10 was acceptable (α = .79 in the adult sample. Convergent validity between average real-time urge intensity scores (as assessed with the real-time urge monitor and the 10-item version of the PUTS (r = .64 and the 9-item version of the PUTS (r = .66 was good. A factor analysis including the 10 items of the PUTS and average real-time urge intensity scores revealed three factors. One factor included the average real-time urge intensity score and appeared to measure urge intensity, while the other two factors can be assumed to reflect the (sensory quality of urges and subjective control, respectively. The factor structure of the 10 PUTS items alone was replicated in a sample of children and adolescents.The results indicate that convergent validity between the PUTS and the real-time urge assessment monitor is good. Furthermore, the results suggest that the PUTS might assess more than one dimension of urges and it may be worthwhile developing different sub-scales of the PUTS assessing premonitory urges in terms of intensity and quality, as well as subjectively

  2. An Extension Convergent Validity Study of the "Systematic Screening for Behavior Disorders" and the Achenbach "Teacher's Report Form" with Middle and High School Students with Emotional Disturbances

    Science.gov (United States)

    Benner, Gregory J.; Uhing, Brad M.; Pierce, Corey D.; Beaudoin, Kathleen M.; Ralston, Nicole C.; Mooney, Paul

    2009-01-01

    We sought to extend instrument validation research for the Systematic Screening for Behavior Disorders (SSBD) (Walker & Severson, 1990) using convergent validation techniques. Associations between Critical Events, Adaptive Behavior, and Maladaptive Behavior indices of the SSBD were examined in relation to syndrome, broadband, and total scores…

  3. Assessing the Validity of Discourse Analysis: Transdisciplinary Convergence

    Science.gov (United States)

    Jaipal-Jamani, Kamini

    2014-01-01

    Research studies using discourse analysis approaches make claims about phenomena or issues based on interpretation of written or spoken text, which includes images and gestures. How are findings/interpretations from discourse analysis validated? This paper proposes transdisciplinary convergence as a way to validate discourse analysis approaches to…

  4. Assessing the Validity of Discourse Analysis: Transdisciplinary Convergence

    Science.gov (United States)

    Jaipal-Jamani, Kamini

    2014-01-01

    Research studies using discourse analysis approaches make claims about phenomena or issues based on interpretation of written or spoken text, which includes images and gestures. How are findings/interpretations from discourse analysis validated? This paper proposes transdisciplinary convergence as a way to validate discourse analysis approaches to…

  5. Assessing the validity of discourse analysis: transdisciplinary convergence

    Science.gov (United States)

    Jaipal-Jamani, Kamini

    2014-12-01

    Research studies using discourse analysis approaches make claims about phenomena or issues based on interpretation of written or spoken text, which includes images and gestures. How are findings/interpretations from discourse analysis validated? This paper proposes transdisciplinary convergence as a way to validate discourse analysis approaches to research. The argument is made that discourse analysis explicitly grounded in semiotics, systemic functional linguistics, and critical theory, offers a credible research methodology. The underlying assumptions, constructs, and techniques of analysis of these three theoretical disciplines can be drawn on to show convergence of data at multiple levels, validating interpretations from text analysis.

  6. Convergent and Divergent Validity of the Devereux Student Strengths Assessment

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    Nickerson, Amanda B.; Fishman, Callen

    2009-01-01

    This study assessed the convergent and divergent validity of the Devereux Student Strengths Assessment (DESSA; LeBuffe, Shapiro, & Naglieri, 2008). A total of 227 (n = 94 teachers, n = 133 parents) raters completed the DESSA, in addition to the Behavioral and Emotional Rating Scales-2 (BERS-2; Epstein, 2004) and/or the Behavior Assessment…

  7. Convergent validity test, construct validity test and external validity test of the David Liberman algorithm

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    David Maldavsky

    2013-08-01

    Full Text Available The author first exposes a complement of a previous test about convergent validity, then a construct validity test and finally an external validity test of the David Liberman algorithm.  The first part of the paper focused on a complementary aspect, the differential sensitivity of the DLA 1 in an external comparison (to other methods, and 2 in an internal comparison (between two ways of using the same method, the DLA.  The construct validity test exposes the concepts underlined to DLA, their operationalization and some corrections emerging from several empirical studies we carried out.  The external validity test examines the possibility of using the investigation of a single case and its relation with the investigation of a more extended sample.

  8. Convergent validity of the Arabic scale of mental health.

    Science.gov (United States)

    Abdel-Khalek, Ahmed M

    2012-02-01

    To estimate the convergent validity of the Arabic Scale of Mental Health, three convenience separate samples (ns = 162, 168, 138) of volunteer Kuwaiti college students, ages 19 to 32 years, responded anonymously to several scales measuring psychopathology. Analyses showed total ratings for the scale correlated negatively with those of the Kuwait University Anxiety Scale, Factorial Arabic Neuroticism Scale, Somatic Symptoms Inventory, Arabic Scale of Insomnia, the nine subscales of the Symptom Checklist-90-R, the Beck Depression Inventory, and the seven subscales of the General Health Questionnaire. Three separate correlation matrices were subjected to principal components analyses for which a single bipolar factor, Mental health versus psychopathology, was retained in all three matrices. Loadings for the Arabic Scale of Mental Health were -.76, -.64, and -.76. It was concluded that this scale has suitable convergent validity.

  9. Just Ask Me: Convergent Validity of Self-Reported Measures of Music Participation

    Science.gov (United States)

    Elpus, Kenneth

    2017-01-01

    The purpose of this study was to determine the convergent validity of self-reported and objective measures of school music ensemble participation. Self-reported survey responses to a question about high school music ensemble participation and administrative data in the form of high school transcript-indicated ensemble enrollments were compared…

  10. Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity

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    Cheyda Chams-Davatchi

    2013-04-01

    Full Text Available Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this study we aimed to introduce the pemphigus vulgaris activity score (PVAS measurement and to assess the convergent validity with the experts’ opinion of disease activity. In PVAS scoring, the distribution of pemphigus vulgaris antigen expression in different anatomical regions is taking in to account with special consideration of the healing process. PVAS is a 0-18 scale, based on the extent of mucocutaneous involvement, type of lesion and the presence of Nikolsky’s sign. The sum of the scores of total number of lesions, number of different anatomic regions involvement and Nikolsky’s sign is weighted by the type of lesion. In the present study, PVAS was assessed in 50 patients diagnosed with pemphigus vulgaris by one dermatologist. Independently, five blinded experts scored all the patients through physician’s global assessment (PGA. The convergent validity with experts’ opinion was assessed. The Spearman coefficient of correlation showed the acceptable value of 0.751 (95%CI: 0.534- 0.876. PVAS is a valid, objective and simple-to-use scoring measurement. It showed a good correlation with PGA of pemphigus disease activity in Iranian patients with pemphigus vulgaris

  11. Convergent and discriminant validity of the Five Factor Form.

    Science.gov (United States)

    Rojas, Stephanie L; Widiger, Thomas A

    2014-04-01

    The current study tests the convergent and discriminant validity of a modified version of the Five Factor Model Rating Form (FFMRF), a one-page, brief measure of the five-factor model. The Five Factor Form (FFF) explicitly identifies maladaptive variants for both poles of each of the 30 facets of the FFMRF. The purpose of the current study was to test empirically whether this modified version still provides a valid assessment of the FFM, as well as to compare its validity as a measure of the FFM to other brief FFM measures. Two independent samples of 510 and 330 community adults were sampled, one third of whom had a history of some form of mental health treatment. The FFF was compared with three abbreviated and/or brief measures of the FFM (i.e., the FFMRF, the Ten Item Personality Inventory, and the Big Five Inventory), a more extended measure (i.e., International Personality Item Pool-NEO), an alternative measure of general personality (i.e., the HEXACO-Personality Inventory-Revised), and a measure of maladaptive personality functioning (i.e., the Personality Inventory for Diagnostic and Statistical Manual of Mental Disorders, 5th edition). The results of the current study demonstrated convergent and discriminant validity, even at the single-item facet level. © The Author(s) 2013.

  12. Pemphigus vulgaris activity score and assessment of convergent validity.

    Science.gov (United States)

    Chams-Davatchi, Cheyda; Rahbar, Ziba; Daneshpazhooh, Maryam; Mortazavizadeh, Seyed Mohammad Ali; Akhyani, Maryam; Esmaili, Nafiseh; Balighi, Kamran

    2013-05-07

    Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this study we aimed to introduce the pemphigus vulgaris activity score (PVAS) measurement and to assess the convergent validity with the experts' opinion of disease activity. In PVAS scoring, the distribution of pemphigus vulgaris antigen expression in different anatomical regions is taking in to account with special consideration of the healing process. PVAS is a 0-18 scale, based on the extent of mucocutaneous involvement, type of lesion and the presence of Nikolsky's sign. The sum of the scores of total number of lesions, number of different anatomic regions involvement and Nikolsky's sign is weighted by the type of lesion. In the present study, PVAS was assessed in 50 patients diagnosed with pemphigus vulgaris by one dermatologist. Independently, five blinded experts scored all the patients through physician's global assessment (PGA). The convergent validity with experts' opinion was assessed. The Spearman coefficient of correlation showed the acceptable value of 0.751 (95%CI: 0.534- 0.876). PVAS is a valid, objective and simple-to-use scoring measurement. It showed a good correlation with PGA of pemphigus disease activity in Iranian patients with pemphigus vulgaris.

  13. Reliability and convergent validity of two outcome instruments for pemphigus.

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    Rosenbach, Misha; Murrell, Dedee F; Bystryn, Jean-Claude; Dulay, Sam; Dick, Sarah; Fakharzadeh, Steve; Hall, Russell; Korman, Neil J; Lin, Julie; Okawa, Joyce; Pandya, Amit G; Payne, Aimee S; Rose, Mathew; Rubenstein, David; Woodley, David; Vittorio, Carmela; Werth, Benjamin B; Williams, Erik A; Taylor, Lynne; Troxel, Andrea B; Werth, Victoria P

    2009-10-01

    A major obstacle in performing multicenter controlled trials for pemphigus is the lack of a validated disease activity scoring system. Here, we assess the reliability and convergent validity of the PDAI (pemphigus disease area index). A group of 10 dermatologists scored 15 patients with pemphigus to estimate the inter- and intra-rater reliability of the PDAI and the recently described ABSIS (autoimmune bullous skin disorder intensity score) instrument. To assess convergent validity, these tools were also correlated with the Physician's Global Assessment (PGA). Reliability studies demonstrated an intra-class correlation coefficient (ICC) for inter-rater reliability of 0.76 (95% confirdence interval (CI)=0.61-0.91) for the PDAI and 0.77 (0.63-0.91) for the ABSIS. The tools differed most in reliability of assessing skin activity, with an ICC of 0.39 (0.17-0.60) for the ABSIS and 0.86 (0.76-0.95) for the PDAI. Intra-rater test-retest reliability demonstrated an ICC of 0.98 (0.96-1.0) for the PDAI and 0.80 (0.65-0.96) for the ABSIS. The PDAI also correlated more closely with the PGA. We conclude that the PDAI is more reproducible and correlates better with physician impression of extent. Subset analysis suggests that for this population of mild-to-moderate disease activity, the PDAI captures more variability in cutaneous disease than the ABSIS.

  14. Convergent, discriminant, and criterion validity of DSM-5 traits.

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    Yalch, Matthew M; Hopwood, Christopher J

    2016-10-01

    Section III of the Diagnostic and Statistical Manual of Mental Disorders (5th edi.; DSM-5; American Psychiatric Association, 2013) contains a system for diagnosing personality disorder based in part on assessing 25 maladaptive traits. Initial research suggests that this aspect of the system improves the validity and clinical utility of the Section II Model. The Computer Adaptive Test of Personality Disorder (CAT-PD; Simms et al., 2011) contains many similar traits as the DSM-5, as well as several additional traits seemingly not covered in the DSM-5. In this study we evaluate the convergent and discriminant validity between the DSM-5 traits, as assessed by the Personality Inventory for DSM-5 (PID-5; Krueger et al., 2012), and CAT-PD in an undergraduate sample, and test whether traits included in the CAT-PD but not the DSM-5 provide incremental validity in association with clinically relevant criterion variables. Results supported the convergent and discriminant validity of the PID-5 and CAT-PD scales in their assessment of 23 out of 25 DSM-5 traits. DSM-5 traits were consistently associated with 11 criterion variables, despite our having intentionally selected clinically relevant criterion constructs not directly assessed by DSM-5 traits. However, the additional CAT-PD traits provided incremental information above and beyond the DSM-5 traits for all criterion variables examined. These findings support the validity of pathological trait models in general and the DSM-5 and CAT-PD models in particular, while also suggesting that the CAT-PD may include additional traits for consideration in future iterations of the DSM-5 system. (PsycINFO Database Record

  15. Validation of the Social Appearance Anxiety Scale: factor, convergent, and divergent validity.

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    Levinson, Cheri A; Rodebaugh, Thomas L

    2011-09-01

    The Social Appearance Anxiety Scale (SAAS) was created to assess fear of overall appearance evaluation. Initial psychometric work indicated that the measure had a single-factor structure and exhibited excellent internal consistency, test-retest reliability, and convergent validity. In the current study, the authors further examined the factor, convergent, and divergent validity of the SAAS in two samples of undergraduates. In Study 1 (N = 323), the authors tested the factor structure, convergent, and divergent validity of the SAAS with measures of the Big Five personality traits, negative affect, fear of negative evaluation, and social interaction anxiety. In Study 2 (N = 118), participants completed a body evaluation that included measurements of height, weight, and body fat content. The SAAS exhibited excellent convergent and divergent validity with self-report measures (i.e., self-esteem, trait anxiety, ethnic identity, and sympathy), predicted state anxiety experienced during the body evaluation, and predicted body fat content. In both studies, results confirmed a single-factor structure as the best fit to the data. These results lend additional support for the use of the SAAS as a valid measure of social appearance anxiety.

  16. Convergent validity of alternative MMPI-2 personality disorder scales.

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    Hicklin, J; Widiger, T A

    2000-12-01

    The Morey, Waugh, and Blashfield (1985) MMPI (Hathaway et al., 1989) personality disorder scales provided a significant contribution to personality disorder research and assessment. However, the subsequent revisions to the MMPI and the multiple revisions to the diagnostic criteria sets that have since occurred may have justified comparable revisions to these scales. Somwaru and Ben-Porath (1995) selected a substantially different set of items from the MMPI-2 (Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) to assess Diagnostic and Statistical Manual of Mental Disorders (4th ed.; American Psychiatric Association, 1994) personality disorder diagnostic criteria. In our study, we compared the convergent validity of these alternative MMPI-2 personality disorder scales with respect to 3 self-report measures of personality disorder symptomatology in a sample of 82 psychiatric outpatients. The results suggested that Somwaru and Ben-Porath's scales are as valid as the original Morey et al. scales and might be even more valid for the assessment of borderline, antisocial, and schizoid personality disorder symptomatology.

  17. Convergent and diagnostic validity of STAVUX, a word and pseudoword spelling test for adults.

    Science.gov (United States)

    Östberg, Per; Backlund, Charlotte; Lindström, Emma

    2016-10-01

    Few comprehensive spelling tests are available in Swedish, and none have been validated in adults with reading and writing disorders. The recently developed STAVUX test includes word and pseudoword spelling subtests with high internal consistency and adult norms stratified by education. This study evaluated the convergent and diagnostic validity of STAVUX in adults with dyslexia. Forty-six adults, 23 with dyslexia and 23 controls, took STAVUX together with a standard word-decoding test and a self-rated measure of spelling skills. STAVUX subtest scores showed moderate to strong correlations with word-decoding scores and predicted self-rated spelling skills. Word and pseudoword subtest scores both predicted dyslexia status. Receiver-operating characteristic (ROC) analysis showed excellent diagnostic discriminability. Sensitivity was 91% and specificity 96%. In conclusion, the results of this study support the convergent and diagnostic validity of STAVUX.

  18. Convergent validity of group tests of cognitive development

    Science.gov (United States)

    Stefanich, Greg P.; Unruh, Roy D.; Perry, Bruce; Phillips, Gary

    This study was designed to investigate the convergent validity of individual clinical task interviews as presented by Piaget and Inhelder paired with three widely used group tests of cognitive development. These tests are designed to assess the acquisition of cognitive abilities. The three group test raw scores paired with summed raw scores on four concrete-formal task interviews yielded the following Pearson product-moment correlations: Reasoning Test (Ankney and Joyce), 0.43; Logical Reasoning Test (Burney), 0.61; Classroom Test of Formal Operations (Lawson), 0.37. The raw data was then ranked into cognitive level groups and presented on contingency tables. The following contingency coefficients were determined: Logical Reasoning Test, 0.52; Logical Reasoning Test (adjusted), 0.61; Classroom Test of Formal Operations, 0.50. This study reflects that the Reasoning Test tends to indicate lower cognitive levels of subjects when paired with summed scores on the clinical task interviews, whereas the Logical Reasoning Test and the Classroom Test of Formal Operations tend to indicate higher cognitive levels of subjects when paired with summed scores on the clinical task interviews. In each case the correlations do not appear to be sufficiently strong to warrant selection or categorization of an individual student based on his/her test performance.

  19. Reliability and convergent validity of the Childhood Anxiety Sensitivity Index in children and adolescents

    Directory of Open Access Journals (Sweden)

    Luciano Isolan

    2012-01-01

    Full Text Available OBJECTIVE: The purpose of this study was to examine the reliability and the convergent validity of the Children Anxiety Sensitivity Index (CASI with DSM-IV anxiety disorder symptoms, by comparison with the Screen for Child Anxiety Related Emotional Disorders (SCARED, in a community sample of Brazilian children and adolescents. METHODS: Children and adolescents from five schools were selected from a larger study that aimed to assess different aspects of childhood anxiety disorders. All participants completed the CASI and the SCARED. RESULTS: This study supported the reliability of the CASI total score. Girls reported higher total anxiety sensitivity scores than boys and there were no differences in total anxiety sensitivity scores between children and adolescents. This study showed moderate to high correlations between the CASI scores with SCARED scores, all correlations coefficients being positive and significant. CONCLUSIONS: Our findings demonstrate an appropriate reliability and evidence of convergent validity in the CASI in a sample of Brazilian children and adolescents.

  20. Convergent Validity of the Aberrant Behavior Checklist and Behavior Problems Inventory with People with Complex Needs

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    Hill, Jennie; Powlitch, Stephanie; Furniss, Frederick

    2008-01-01

    The current study aimed to replicate and extend Rojahn et al. [Rojahn, J., Aman, M. G., Matson, J. L., & Mayville, E. (2003). "The aberrant behavior checklist and the behavior problems inventory: Convergent and divergent validity." "Research in Developmental Disabilities", 24, 391-404] by examining the convergent validity of the behavior problems…

  1. Where Low and High Inference Data Converge: Validation of CLASS Assessment of Mathematics Instruction Using Mobile Eye Tracking with Expert and Novice Teachers

    Science.gov (United States)

    Cortina, Kai S.; Miller, Kevin F.; McKenzie, Ryan; Epstein, Alanna

    2015-01-01

    Classroom observation research and research on teacher expertise are similar in their reliance on observational data with high-inference procedure to assess the quality of instruction. Expertise research usually uses low-inference measures like eye tracking to identify qualitative difference between expert and novice behaviors and cognition. In…

  2. Where Low and High Inference Data Converge: Validation of CLASS Assessment of Mathematics Instruction Using Mobile Eye Tracking with Expert and Novice Teachers

    Science.gov (United States)

    Cortina, Kai S.; Miller, Kevin F.; McKenzie, Ryan; Epstein, Alanna

    2015-01-01

    Classroom observation research and research on teacher expertise are similar in their reliance on observational data with high-inference procedure to assess the quality of instruction. Expertise research usually uses low-inference measures like eye tracking to identify qualitative difference between expert and novice behaviors and cognition. In…

  3. Convergent and discriminant validity of alternative measures of maladaptive personality traits.

    Science.gov (United States)

    Crego, Cristina; Widiger, Thomas A

    2016-12-01

    The purpose of the current study was to test empirically the convergent and discriminant validity of 3 recently developed, alternative measures of maladaptive personality traits: the Personality Inventory for Diagnostic and Statistical Manual for Mental Disorders-Fifth Edition (DSM-5, PID-5; Krueger, Derringer, Markon, Watson, & Skodol, 2012), the Computerized Adaptive Test-Personality Disorder Static Form (CAT-PD-SF; Simms et al., 2011), and Five Factor Model Personality Disorder scales (FFMPD; Widiger, Lynam, Miller, & Oltmanns, 2012). These measures were constructed with different rationales and methods, yet the result was highly congruent. The PID-5 and CAT-PD-SF were administered to 286 community adults with current or a history of mental health treatment; the CAT-PD-SF and FFMPD scales to 262 such adults; and the PID-5 and FFMPD scales to 266. The results indicated good to excellent internal consistency, as well as good to excellent convergent and discriminant validity for most scales with a few notable exceptions. Suggestions for future research are provided, including the potential benefits of scales that are unique to a respective instrument, replication of a dependency factor, and exploration as to the basis for instances of questionable convergent or discriminant validity. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  4. Convergence

    DEFF Research Database (Denmark)

    Madsen, Ole Brun; Nielsen, Jens Frederik Dalsgaard; Schiøler, Henrik

    2002-01-01

    Convergence trends between the WAN Internet area, characterized by best effort service provision, and the real time LAN domain, with requirements for guaranteed services, are identified and discussed. A bilateral evolution is identified, where typical bulk service applications from WAN...

  5. Convergence

    Science.gov (United States)

    Darcie, Thomas E.; Doverspike, Robert; Zirngibl, Martin; Korotky, Steven K.

    2005-09-01

    Call for Papers: Convergence The Journal of Optical Networking (JON) invites submissions to a special issue on Convergence. Convergence has become a popular theme in telecommunications, one that has broad implications across all segments of the industry. Continual evolution of technology and applications continues to erase lines between traditionally separate lines of business, with dramatic consequences for vendors, service providers, and consumers. Spectacular advances in all layers of optical networking-leading to abundant, dynamic, cost-effective, and reliable wide-area and local-area connections-have been essential drivers of this evolution. As services and networks continue to evolve towards some notion of convergence, the continued role of optical networks must be explored. One vision of convergence renders all information in a common packet (especially IP) format. This vision is driven by the proliferation of data services. For example, time-division multiplexed (TDM) voice becomes VoIP. Analog cable-television signals become MPEG bits streamed to digital set-top boxes. T1 or OC-N private lines migrate to Ethernet virtual private networks (VPNs). All these packets coexist peacefully within a single packet-routing methodology built on an optical transport layer that combines the flexibility and cost of data networks with telecom-grade reliability. While this vision is appealing in its simplicity and shared widely, specifics of implementation raise many challenges and differences of opinion. For example, many seek to expand the role of Ethernet in these transport networks, while massive efforts are underway to make traditional TDM networks more data friendly within an evolved but backward-compatible SDH/SONET (synchronous digital hierarchy and synchronous optical network) multiplexing hierarchy. From this common underlying theme follow many specific instantiations. Examples include the convergence at the physical, logical, and operational levels of voice and

  6. Convergence

    DEFF Research Database (Denmark)

    Prasad, Ramjee

    2009-01-01

    This paper presents the main conclusions which can be drawn from the discussions on Future Communication Systems and lessons on Unpredictable Future of Wireless Communication Systems. Future systems beyond the third generation are already under discussions in international bodies, such as ITU, WW...... and R&D programmes worldwide. The incoming era is characterized by the convergence of networks and access technology and the divergence of applications. Future mobile communication systems should bring something more than only faster data or wireless internet access....

  7. Convergent and discriminant validity of FIRO-B questionnaire.

    Science.gov (United States)

    Salminen, S

    1991-12-01

    The Kramer-Froehle controversy about the construct validity of FIRO-B questionnaire was evaluated with a multitrait-multimethod design. 113 women and 26 men completed the FIRO-B questionnaire. After the examiner had given a lecture on the FIRO-dimensions, the subjects rated themselves on these dimensions. Only three out of six intercorrelations on the validity diagonal were statistically significant. Of the discriminant validity comparisons 80% met the required criterion. Our results confirmed Kramer's results about the construct validity of the FIRO-B questionnaire.

  8. Emotional intelligence: new ability or renowned traits? An investigation of the convergent, discriminant and incremental validity

    OpenAIRE

    Wan Husin, Wan Nurul Izza

    2017-01-01

    Despite the recent popularity of the concept of emotional intelligence, several researchers question current emotional intelligence tests on several grounds including their lack of construct validity and unstable factor structure. This thesis aims to investigate the construct validity of emotional intelligence. In particular, the present study seeks to (1) confirm the factorial validity of emotional intelligence, (2) examine the convergent validity between a performance-based test and self-re...

  9. The convergent and discriminant validity of burnout measures in sport: a multi-trait/multi-method analysis.

    Science.gov (United States)

    Cresswell, Scott L; Eklund, Robert C

    2006-02-01

    Athlete burnout research has been hampered by the lack of an adequate measurement tool. The Athlete Burnout Questionnaire (ABQ) and the Maslach Burnout Inventory General Survey (MBI-GS) are two recently developed self-report instruments designed to assess burnout. The convergent and discriminant validity of the ABQ and MBI-GS were assessed through multi-trait/multi-method analysis with a sporting population. Overall, the ABQ and the MBI-GS displayed acceptable convergent validity with matching subscales highly correlated, and satisfactory internal discriminant validity with lower correlations between non-matching subscales. Both scales also indicated an adequate discrimination between the concepts of burnout and depression. These findings add support to previous findings in non-sporting populations that depression and burnout are separate constructs. Based on the psychometric results, construct validity analysis and practical considerations, the results support the use of the ABQ to assess athlete burnout.

  10. Inter-rater reliability and convergent validity of F1000Prime peer review

    CERN Document Server

    Bornmann, Lutz

    2014-01-01

    Peer review is the backbone of modern science. F1000Prime is a post-publication peer review system of the biomedical literature (papers from medical and biological journals). This study is concerned with the inter-rater reliability and convergent validity of the peer recommendations formulated in the F1000Prime peer review system. The study is based on around 100,000 papers with recommendations from Faculty members. Even if intersubjectivity plays a fundamental role in science, the analyses of the reliability of the F1000Prime peer review system show a rather low level of agreement between Faculty members. This result is in agreement with most other studies which have been published on the journal peer review system. Logistic regression models are used to investigate the convergent validity of the F1000Prime peer review system. As the results show, the proportion of highly cited papers among those selected by the Faculty members is significantly higher than expected. In addition, better recommendation scores ...

  11. Assessing Physical Activity in Children with Asthma: Convergent Validity between Accelerometer and Electronic Diary Data

    Science.gov (United States)

    Floro, Josh N.; Dunton, Genevieve F.; Delfino, Ralph J.

    2009-01-01

    Convergent validity of accelerometer and electronic diary physical activity data was assessed in children with asthma. Sixty-two participants, ages 9-18 years, wore an accelerometer and reported their physical activity level in quarter-hour segments every 2 hr using the Ambulatory Diary Assessment (ADA). Moderate validity was found between…

  12. Convergent and Discriminant Validation of Oral Language Proficiency Tests.

    Science.gov (United States)

    Bachman, Lyle F.; Palmer, Adrian S.

    In a study designed to validate oral language proficiency tests, it is planned to administer a series of tests to 100 native Mandarin Chinese-speaking subjects (foreign students and their spouses). The tests will measure communicative competence in speaking (ability to speak, exhibiting control of linguistic, sociolinguistic, and pragmatic rules;…

  13. Analyzing the Convergent and Discriminant Validity of States and Traits: Development and Applications of Multimethod Latent State-Trait Models

    Science.gov (United States)

    Courvoisier, Delphine S.; Nussbeck, Fridtjof W.; Eid, Michael; Geiser, Christian; Cole, David A.

    2008-01-01

    The analysis of convergent and discriminant validity is an integral part of the construct validation process. Models for analyzing the convergent and discriminant validity have typically been developed for cross-sectional data. There exist, however, only a few approaches for longitudinal data that can be applied for analyzing the construct…

  14. Generation of High Pressure and Temperature by Converging Detonation Waves

    Directory of Open Access Journals (Sweden)

    V. P. Singh

    1987-07-01

    Full Text Available Generation of high pressure and temperature has various applications in defence. Several techniques, viz flying plate method, collapsing of linear, convergence of detonation waves in solid explosives, have been established in this connection. In the present paper, converging detonation waves in solid explosives, where variable heat of detonation is being added to the front, is studied, by using Whitham's characteristics rule. Results are compared with those reported elsewhere.

  15. Generation of High Pressure and Temperature by Converging Detonation Waves

    OpenAIRE

    Singh, V. P.; Shukla, S K

    1987-01-01

    Generation of high pressure and temperature has various applications in defence. Several techniques, viz flying plate method, collapsing of linear, convergence of detonation waves in solid explosives, have been established in this connection. In the present paper, converging detonation waves in solid explosives, where variable heat of detonation is being added to the front, is studied, by using Whitham's characteristics rule. Results are compared with those reported elsewhere.

  16. Generation of high pressure and temperature by converging detonation waves

    Science.gov (United States)

    Singh, V. P.; Shukla, S. K.

    1987-07-01

    Generation of high pressure and temperature has various applications in defense. Several techniques, viz flying plate method, collapsing of linear, convergence of detonation waves in solid explosives, have been established in this connection. In this paper, converging detonation waves in solid explosives, where variable heat of detonation is being added to the front, are studied by using Whitham's characteristics rule. Results are compared with those reported elsewhere.

  17. Global Positioning System Technology (GPS for Psychological Research: A Test of Convergent and Nomological Validity

    Directory of Open Access Journals (Sweden)

    Pedro eWolf

    2013-06-01

    Full Text Available The purpose of this paper is to examine the convergent and nomological validity of a GPS-based measure of daily activity, operationalized as Number of Places Visited (NPV. Relations among the GPS-based measure and two self-report measures of NPV, as well as relations among NPV and two factors made up of self-reported individual differences were examined. The first factor was composed of variables related to an Active Lifestyle (AL (e.g. positive affect, extraversion… and the second factor was composed of variables related to a Sedentary Lifestyle (SL (e.g. depression, neuroticism…. NPV was measured over a four-day period. This timeframe was made up of two week and two weekend days. A bi-variate analysis established one level of convergent validity and a Split-Plot GLM examined convergent validity, nomological validity, and alternative hypotheses related to constraints on activity throughout the week simultaneously. The first analysis revealed significant correlations among NPV measures- weekday, weekend, and the entire four day blocks, supporting the convergent validity of the Diary-, Google Maps-, and GPS-NPV measures. Results from the second analysis, indicating non-significant mean differences in NPV regardless of method, also support this conclusion. We also found that AL is a statistically significant predictor of NPV no matter how NPV was measured. We did not find a statically significant relation among NPV and SL. These results permit us to infer that the GPS-based NPV measure has convergent and nomological validity.

  18. Indirectly driven, high-convergence implosions (HEP1)

    Energy Technology Data Exchange (ETDEWEB)

    Hatchett, S.P.; Cable, M.D.; Caird, J.A. [and others

    1996-06-01

    High-gain inertial confinement fusion will most readily be achieved with hot-spot ignition, in which a relatively small mass of gaseous fuel at the center of the target is heated to 5-10 keV, igniting a larger surrounding mass of approximately isobaric fuel at higher density but lower temperature. Existing lasers are too low in energy to achieve thermonuclear gain, but hydrodynamically equivalent implosions using these lasers can demonstrate that the important, scalable parameters of ignition capsules are scientifically and technologically achievable. The experiments described in this article used gas-filled glass shells driven by x rays produced in a surrounding cavity, or hohlraum. These implosions achieved convergence ratios (initial capsule radius/ final fuel radius) high enough to fall in the range required for ignition-scale capsules, and they produced an imploded configuration (high-density glass with hot gas fill) that is equivalent to the hot-spot configuration of an ignition-scale capsule. Other recent laser-driven implosions have achieved high shell density but at lower convergences and without a well defined hot spot. Still other experiments have used very-low-density gas fill to reach high convergence with unshaped drive, but that approach results in a relatively low shell density. Moreover, even at the highest convergence ratios the implosions described here had neutron yields averaging 8% of that calculated for an idealized, clean, spherically symmetric implosion - much higher than previous high-convergence experiments.

  19. Writing Readiness Inventory Tool in Context (WRITIC): reliability and convergent validity

    NARCIS (Netherlands)

    Hartingsveldt, M.J. van; Cup, E.H.C.; Groot, I.J.M. de; Nijhuis-Van der Sanden, M.W.

    2014-01-01

    BACKGROUND/AIM: This study examined the reliability and convergent validity of the Writing Readiness Inventory Tool in Context, a measurement evaluating writing readiness in kindergarten children (aged from five to six years). METHODS: Test-retest reliability was established with 59 children, inter-

  20. Examining the Convergent and Discriminant Validity of Visual and Mental Workload Using Ocular Activity Variables

    Science.gov (United States)

    2010-03-01

    electrodermal activity , topographically recorded electrical brain activity , and subjective measures of workload were recorded. In order to ensure...1994, 369, 742–744. Lowenstein, O.; Loewenfield, I. E. The Sleep -waking Cycle and Pupillary Activity . Annals of the New York Academy of Sciences 1964...Examining the Convergent and Discriminant Validity of Visual and Mental Workload Using Ocular Activity Variables by Michael Sage Jessee

  1. The Convergent Validities of Two Measures of Dating Behaviors Related to Risk for Sexual Victimization

    Science.gov (United States)

    Breitenbecher, Kimberly Hanson

    2008-01-01

    The primary purpose of this investigation was to assess the convergent validities of two measures of dating behaviors related to risk for sexual victimization, the Dating Self-Protection Against Rape Scale (DSPARS) and the Dating Behavior Survey (DBS). Three hundred seventy-seven women responded to measures assessing self-protective dating…

  2. Further Examination of the Convergent and Discriminant Validity of the Student-Teacher Relationship Scale

    Science.gov (United States)

    Doumen, Sarah; Verschueren, Karine; Buyse, Evelien; De Munter, Sofie; Max, Kristel; Moens, Loth

    2009-01-01

    Two studies extended psychometric research on the Student-Teacher Relationship Scale (STRS) with kindergarten and preschool children (N[subscript 1] = 60-7[subscript 1]; N[subscript 2] = 35) and their teachers. These studies used a multi-method approach to replicate and extend previous findings concerning the convergent validity of the STRS…

  3. The Neurological Outcome Scale for Traumatic Brain Injury (NOS-TBI): II. Reliability and convergent validity.

    Science.gov (United States)

    McCauley, Stephen R; Wilde, Elisabeth A; Kelly, Tara M; Weyand, Annie M; Yallampalli, Ragini; Waldron, Eric J; Pedroza, Claudia; Schnelle, Kathleen P; Boake, Corwin; Levin, Harvey S; Moretti, Paolo

    2010-06-01

    A standardized measure of neurological dysfunction specifically designed for TBI currently does not exist and the lack of assessment of this domain represents a substantial gap. To address this, the Neurological Outcome Scale for Traumatic Brain Injury (NOS-TBI) was developed for TBI outcomes research through the addition to and modification of items specifically relevant to patients with TBI, based on the National Institutes of Health Stroke Scale. In a sample of 50 participants (mean age = 33.3 years, SD = 12.9) TBI, internal consistency of the NOS-TBI was high (Cronbach's alpha = 0.942). Test-retest reliability also was high (rho = 0.97, p TBI total score was excellent (W = 0.995). Convergent validity was demonstrated through significant Spearman rank-order correlations between the NOS-TBI and the concurrently administered Disability Rating Scale (rho = 0.75, p TBI is a reliable and valid measure of neurological functioning in patients with moderate to severe TBI.

  4. Convergent evidence for construct validity of a 7-point likert scale of lower limb muscle soreness.

    Science.gov (United States)

    Impellizzeri, Franco M; Maffiuletti, Nicola A

    2007-11-01

    The aim of this study was to examine the construct validity of the 7-point Likert scale of muscle soreness, assessing its relationship with Visual Analogue Scale (VAS). An additional aim was to examine its sensitivity as measure of symptom of eccentric-contraction muscle damage. Correlational study. Self-administered questionnaires collected in field setting. Twenty-six soccer players. 4-week preseason training camp, which included high-intensity plyometric training sessions. Players self-reported the perceived muscle soreness of the lower limbs using the VAS (criterion measure) and the 7-point Likert scale of muscle soreness. Significant individual correlations were found between the 2 muscle soreness scales (mean r=0.80+/-0.07; range, 0.65 to 0.94). The correlation using the pooled data was 0.81. No significant muscle soreness scale x time interaction was found for standardized measures of muscle soreness (P=0.98). The main factor for time (24, 48, 72, and 96 hours after the first plyometric training session) was significant (P=0.0001). Effect sizes for the changes in the Likert and VAS absolute scores during the first 96 hours were similar (partial eta=0.13). The results of this study provide further convergent evidence for the construct validity of the 7-point Likert scale of muscle soreness. The 2 scales showed similar sensitivity to muscle soreness caused by eccentric contractions during the first 96 hours after plyometric exercises.

  5. Psychometric properties of the mobility inventory for agoraphobia: convergent, discriminant, and criterion-related validity.

    Science.gov (United States)

    Chambless, Dianne L; Sharpless, Brian A; Rodriguez, Dianeth; McCarthy, Kevin S; Milrod, Barbara L; Khalsa, Shabad-Ratan; Barber, Jacques P

    2011-12-01

    Aims of this study were (a) to summarize the psychometric literature on the Mobility Inventory for Agoraphobia (MIA), (b) to examine the convergent and discriminant validity of the MIA's Avoidance Alone and Avoidance Accompanied rating scales relative to clinical severity ratings of anxiety disorders from the Anxiety Disorders Interview Schedule (ADIS), and (c) to establish a cutoff score indicative of interviewers' diagnosis of agoraphobia for the Avoidance Alone scale. A meta-analytic synthesis of 10 published studies yielded positive evidence for internal consistency and convergent and discriminant validity of the scales. Participants in the present study were 129 people with a diagnosis of panic disorder. Internal consistency was excellent for this sample, α=.95 for AAC and .96 for AAL. When the MIA scales were correlated with interviewer ratings, evidence for convergent and discriminant validity for AAL was strong (convergent r with agoraphobia severity ratings=.63 vs. discriminant rs of .10-.29 for other anxiety disorders) and more modest but still positive for AAC (.54 vs. .01-.37). Receiver operating curve analysis indicated that the optimal operating point for AAL as an indicator of ADIS agoraphobia diagnosis was 1.61, which yielded sensitivity of .87 and specificity of .73.

  6. Stair climbing test post-stroke: feasibility, convergent validity and metabolic, cardiac, and respiratory responses.

    Science.gov (United States)

    Modai, Galia; Sharon, Barak; Bar-Haim, S; Hutzler, Y

    2015-08-01

    The 6-minute walk test (6MWT) and treadmill walk tests (TMW) are commonly used to assess post-stroke patients (PSP) aerobic capacity. However, these tests are not without their limitations (e.g. limited sensitivity to change and the use of external pacing). Therefore, there is a need for additional tools to assess PSP aerobic capacity. To establish the feasibility, convergent validity, and metabolic, cardiac, and respiratory responses of a stair climbing test (SC), among chronic PSP. Nineteen chronic PSP conducted SC, TMW, and 6 MWT. Metabolic (oxygen consumption - VO₂), cardiac (heart rate), and respiratory (ventilation volume, breathing frequency, and tidal volume) measures were established. Adverse events were documented. Correlations established the convergent validity of the SC test. A repeated measures analysis of variance was performed to compare the participant's physiological responses at the end of the various tests. SC is feasible and safe, as all participants completed the test with no adverse events. The SC demonstrated convergent validity as numerous associations were found between SC and TMW, and 6 MWT. Metabolic, cardiac, and respiratory responses to the SC were significantly higher than these of the TMW and 6 MWT (e.g. VO₂= 13.43 ± 2.19, 11.01 ± 2.0, and 11.26 ± 1.87 ml/kg/min, respectively) (P stairs is a common community ambulation requirement. Therefore, it is appropriate to incorporate SC test in PSP testing battery.

  7. Bilingual Advantages in Executive Functioning: Problems in Convergent Validity, Discriminant Validity, and the Identification of the Theoretical Constructs

    Directory of Open Access Journals (Sweden)

    Kenneth R. Paap

    2014-09-01

    Full Text Available A sample of 58 bilingual and 62 monolingual university students completed four tasks commonly used to test for bilingual advantages in executive functioning (EF: antisaccade, flanker, Simon, and color-shape switching. Across the four tasks, 13 different indices were derived that are assumed to reflect individual differences in inhibitory control, monitoring, or switching. The effects of bilingualism on the 13 measures were explored by directly comparing the means of the two language groups and through regression analyses using a continuous measure of bilingualism and multiple demographic characteristics as predictors. Across the 13 different measures and two types of data analysis there were very few significant results and those that did occur supported a monolingual advantage. An equally important goal was to assess the convergent validity through cross-task correlations of indices assume to measure the same component of executive functioning. Most of the correlations using difference-score measures were nonsignificant and many near zero. Although modestly higher levels of convergent validity are sometimes reported, a review of the existing literature suggests that bilingual advantages (or disadvantages may reflect task-specific differences that are unlikely to generalize to important general differences in EF. Finally, as cautioned by Salthouse, assumed measures of executive functioning may also be threatened by a lack of divergent validity that separates individual or group differences in EF from those in general fluid intelligence or simple processing speed.

  8. Internal Consistency and Convergent Validity of the Klontz Money Behavior Inventory (KMBI

    Directory of Open Access Journals (Sweden)

    Colby D. Taylor

    2015-12-01

    Full Text Available The Klontz Money Behavior Inventory (KMBI is a standalone, multi-scale measure than can screen for the presence of eight distinct money disorders. Given the well-established relationship between mental health and financial behaviors, results from the KMBI can be used to inform both mental health care professionals and financial planners. The present study examined the internal consistency and convergent validity of the KMBI, through comparison with similar measures, among a sample of college students (n = 232. Results indicate that the KMBI demonstrates acceptable internal consistency reliability and some convergence for most subscales when compared to other analogous measures. These findings highlight a need for literature and assessments to identify and describe disordered money behaviors.

  9. AULA virtual reality test as an attention measure: convergent validity with Conners' Continuous Performance Test.

    Science.gov (United States)

    Díaz-Orueta, Unai; Garcia-López, Cristina; Crespo-Eguílaz, Nerea; Sánchez-Carpintero, Rocío; Climent, Gema; Narbona, Juan

    2014-01-01

    The majority of neuropsychological tests used to evaluate attention processes in children lack ecological validity. The AULA Nesplora (AULA) is a continuous performance test, developed in a virtual setting, very similar to a school classroom. The aim of the present study is to analyze the convergent validity between the AULA and the Continuous Performance Test (CPT) of Conners. The AULA and CPT were administered correlatively to 57 children, aged 6-16 years (26.3% female) with average cognitive ability (IQ mean = 100.56, SD = 10.38) who had a diagnosis of attention deficit/hyperactivity disorder (ADHD) according to DSM-IV-TR criteria. Spearman correlations analyses were conducted among the different variables. Significant correlations were observed between both tests in all the analyzed variables (omissions, commissions, reaction time, and variability of reaction time), including for those measures of the AULA based on different sensorial modalities, presentation of distractors, and task paradigms. Hence, convergent validity between both tests was confirmed. Moreover, the AULA showed differences by gender and correlation to Perceptual Reasoning and Working Memory indexes of the WISC-IV, supporting the relevance of IQ measures in the understanding of cognitive performance in ADHD. In addition, the AULA (but not Conners' CPT) was able to differentiate between ADHD children with and without pharmacological treatment for a wide range of measures related to inattention, impulsivity, processing speed, motor activity, and quality of attention focus. Additional measures and advantages of the AULA versus Conners' CPT are discussed.

  10. Convergence of electronic bands for high performance bulk thermoelectrics.

    Science.gov (United States)

    Pei, Yanzhong; Shi, Xiaoya; LaLonde, Aaron; Wang, Heng; Chen, Lidong; Snyder, G Jeffrey

    2011-05-01

    Thermoelectric generators, which directly convert heat into electricity, have long been relegated to use in space-based or other niche applications, but are now being actively considered for a variety of practical waste heat recovery systems-such as the conversion of car exhaust heat into electricity. Although these devices can be very reliable and compact, the thermoelectric materials themselves are relatively inefficient: to facilitate widespread application, it will be desirable to identify or develop materials that have an intensive thermoelectric materials figure of merit, zT, above 1.5 (ref. 1). Many different concepts have been used in the search for new materials with high thermoelectric efficiency, such as the use of nanostructuring to reduce phonon thermal conductivity, which has led to the investigation of a variety of complex material systems. In this vein, it is well known that a high valley degeneracy (typically ≤6 for known thermoelectrics) in the electronic bands is conducive to high zT, and this in turn has stimulated attempts to engineer such degeneracy by adopting low-dimensional nanostructures. Here we demonstrate that it is possible to direct the convergence of many valleys in a bulk material by tuning the doping and composition. By this route, we achieve a convergence of at least 12 valleys in doped PbTe(1-x)Se(x) alloys, leading to an extraordinary zT value of 1.8 at about 850 kelvin. Band engineering to converge the valence (or conduction) bands to achieve high valley degeneracy should be a general strategy in the search for and improvement of bulk thermoelectric materials, because it simultaneously leads to a high Seebeck coefficient and high electrical conductivity.

  11. Evidence of convergent and discriminant validity of the Student School Engagement Measure.

    Science.gov (United States)

    Hazel, Cynthia E; Vazirabadi, G Emma; Albanes, Jennifer; Gallagher, John

    2014-09-01

    The purpose of this study was to investigate the convergent and discriminant validity of the Student School Engagement Measure (SSEM) with 3 other measures of student well-being: (a) the School Engagement Scale, (b) the Student Engagement Instrument, and (c) the Student Life Satisfaction Survey. The data were analyzed from 370 8th-grade students from 3 middle schools in an urban school district. As hypothesized, strong and significant positive correlations (.80) were found between the SSEM and the 2 measures of engagement (the School Engagement Measure and the Student Engagement Instrument). Also as hypothesized, a weak but significant positive correlation (.35) was found between the SSEM and a measure of life satisfaction (the Student Life Satisfaction Survey). These findings provide additional support for using the SSEM as a valid measure of adolescents' engagement with school.

  12. The factor structure, metrical properties, and convergent validity of the third edition (1999 of the locus of control inventory

    Directory of Open Access Journals (Sweden)

    Johann M Schepers

    2006-02-01

    Full Text Available The principal objective of the study was to examine the factor structure and metrical properties of the third edition (1999 of the Locus of Control Inventory (LCI. A corollary of the study was to examine the convergent validity of the instrument. After a thorough revision and extension of the scale to 88 items it was applied to a sample of 2091 first-year university students. Particular attention was paid to the shortcomings revealed in a study by de Bruin (2004. An iterative principal factor analysis of the scale was done. The three-factor-structure previously found was substantiated by the analysis. The obtained factors were interpreted as Autonomy, External Control and Internal Control. Highly acceptable reliabilities were obtained. As far as validity is concerned it was found that Internal Control and Autonomy are strongly related to Psychological Wellness and External Control negatively to Stress Management. The implications of the findings are discussed.

  13. Convergent validity between SF-36 and WHOQOL-BREF in older adults

    Directory of Open Access Journals (Sweden)

    Paula Costa Castro

    2014-02-01

    Full Text Available OBJECTIVE : To compare the reliability and convergent validity of instruments assessing quality of life in Brazilian older adults. METHODS : Cross-sectional study of 278 literate, community-dwelling older adults attending a municipal university for the elderly in Sao Carlos, SP, Southeastern Brazil between 2006 and 2008. The Brazilian versions of the SF-36 and WHOQOL-BREF instruments to assess quality of life were compared. Cronbach’s alpha coefficient was used to estimate reliability and Pearson’s correlation for comparison between the two scales. RESULTS : Most of participants were women (87.8% with a mean age of 63.83±7.22 years. Both scales showed an acceptable internal consistency – WHOQOL-BREF Cronbach’s alpha was 0.832 and SF-36 was 0.868. There was a weak (r ≤ 0.6 correlation between the related fields in the two questionnaires. CONCLUSIONS : The SF-36 and WHOQOL-BREF are reliable instruments for clinical and research uses in Brazilian older women. To select one, researchers should consider which aspects of quality of life they aim to capture because of weak convergent validity signs. This study’s results indicate that WHOQOL-BREF may be more relevant to evaluate changes in the quality of life of older women because it prioritizes responses to the aging process and avoids focusing on impairment.

  14. Convergent validity between SF-36 and WHOQOL-BREF in older adults

    Science.gov (United States)

    Castro, Paula Costa; Driusso, Patrícia; Oishi, Jorge

    2014-01-01

    OBJECTIVE To compare the reliability and convergent validity of instruments assessing quality of life in Brazilian older adults. METHODS Cross-sectional study of 278 literate, community-dwelling older adults attending a municipal university for the elderly in Sao Carlos, SP, Southeastern Brazil between 2006 and 2008. The Brazilian versions of the SF-36 and WHOQOL-BREF instruments to assess quality of life were compared. Cronbach’s alpha coefficient was used to estimate reliability and Pearson’s correlation for comparison between the two scales. RESULTS Most of participants were women (87.8%) with a mean age of 63.83±7.22 years. Both scales showed an acceptable internal consistency – WHOQOL-BREF Cronbach’s alpha was 0.832 and SF-36 was 0.868. There was a weak (r ≤ 0.6) correlation between the related fields in the two questionnaires. CONCLUSIONS The SF-36 and WHOQOL-BREF are reliable instruments for clinical and research uses in Brazilian older women. To select one, researchers should consider which aspects of quality of life they aim to capture because of weak convergent validity signs. This study’s results indicate that WHOQOL-BREF may be more relevant to evaluate changes in the quality of life of older women because it prioritizes responses to the aging process and avoids focusing on impairment. PMID:24789638

  15. All framing effects are not created equal: Low convergent validity between two classic measurements of framing.

    Science.gov (United States)

    Zhen, Shanshan; Yu, Rongjun

    2016-07-20

    Human risk-taking attitudes can be influenced by two logically equivalent but descriptively different frames, termed the framing effect. The classic hypothetical vignette-based task (Asian disease problem) and a recently developed reward-based gambling task have been widely used to assess individual differences in the framing effect. Previous studies treat framing bias as a stable trait that has genetic basis. However, these two paradigms differ in terms of task domain (loss vs. gain) and task context (vignette-based vs. reward-based) and the convergent validity of these measurements remains unknown. Here, we developed a vignette-based task and a gambling task in both gain and loss domains and tested correlations of the framing effect among these tasks in 159 young adults. Our results revealed no significant correlation between the vignette-based task in the loss domain and the gambling task in the gain domain, indicating low convergent validity. The current findings raise the question of how to measure the framing effect precisely, especially in individual difference studies using large samples and expensive neuroscience methods. Our results suggest that the framing effect is influenced by both task domain and task context and future research should be cautious about the operationalization of the framing effect.

  16. Further validation of the Satisfaction with Life Scale: evidence for the cross-method convergence of well-being measures.

    Science.gov (United States)

    Pavot, W; Diener, E; Colvin, C R; Sandvik, E

    1991-08-01

    The structure of subjective well-being has been conceptualized as consisting of two major components: the emotional or affective component and the judgmental or cognitive component (Diener, 1984; Veenhoven, 1984). The judgmental component has also been conceptualized as life satisfaction (Andrews & Withey, 1976). Although the affective component of subjective well-being has received considerable attention from researchers, the judgmental component has been relatively neglected. The Satisfaction With Life Scale (SWLS; Diener, Emmons, Larsen, & Griffin, 1985) was developed as a measure of the judgmental component of subjective well-being (SWB). Two studied designed to validate further the SWLS are reported. Peer reports, a memory measure, and clinical ratings are used as external criteria for validation. Evidence for the reliability and predictive validity of the SWLS is presented, and its performance is compared to other related scales. The SWLS is shown to be a valid and reliable measure of life satisfaction, suited for use with a wide range of age groups and applications, which makes possible the savings of interview time and resources compared to many measures of life satisfaction. In addition, the high convergence of self- and peer-reported measures of subjective well-being and life satisfaction provide strong evidence that subjective well-being is a relatively global and stable phenomenon, not simply a momentary judgment based on fleeting influences.

  17. Convergent Validity of the Arab Teens Lifestyle Study (ATLS Physical Activity Questionnaire

    Directory of Open Access Journals (Sweden)

    Hazzaa M. Al-Hazzaa

    2011-09-01

    Full Text Available The Arab Teens Lifestyle Study (ATLS is a multicenter project for assessing the lifestyle habits of Arab adolescents. This study reports on the convergent validity of the physical activity questionnaire used in ATLS against an electronic pedometer. Participants were 39 males and 36 females randomly selected from secondary schools, with a mean age of 16.1 ± 1.1 years. ATLS self-reported questionnaire was validated against the electronic pedometer for three consecutive weekdays. Mean steps counts were 6,866 ± 3,854 steps/day with no significant gender difference observed. Questionnaire results showed no significant gender differences in time spent on total or moderate-intensity activities. However, males spent significantly more time than females on vigorous-intensity activity. The correlation of steps counts with total time spent on all activities by the questionnaire was 0.369. Relationship of steps counts was higher with vigorous-intensity (r = 0.338 than with moderate-intensity activity (r = 0.265. Pedometer steps counts showed higher correlations with time spent on walking (r = 0.350 and jogging (r = 0.383 than with the time spent on other activities. Active participants, based on pedometer assessment, were also most active by the questionnaire. It appears that ATLS questionnaire is a valid instrument for assessing habitual physical activity among Arab adolescents.

  18. Convergent, discriminant, and incremental validity of competing measures of emotional intelligence.

    Science.gov (United States)

    Brackett, Marc A; Mayer, John D

    2003-09-01

    This study investigated the convergent, discriminant, and incremental validity of one ability test of emotional intelligence (EI)--the Mayer-Salovey-Caruso-Emotional Intelligence Test (MSCEIT)--and two self-report measures of EI--the Emotional Quotient Inventory (EQ-i) and the self-report EI test (SREIT). The MSCEIT showed minimal relations to the EQ-i and SREIT, whereas the latter two measures were moderately interrelated. Among EI measures, the MSCEIT was discriminable from well-studied personality and well-being measures, whereas the EQ-i and SREIT shared considerable variance with these measures. After personality and verbal intelligence were held constant, the MSCEIT was predictive of social deviance, the EQ-i was predictive of alcohol use, and the SREIT was inversely related to academic achievement. In general, results showed that ability EI and self-report EI are weakly related and yield different measurements of the same person.

  19. Convergent validity of the ASAM Patient Placement Criteria using a standardized computer algorithm.

    Science.gov (United States)

    Staines, Graham; Kosanke, Nicole; Magura, Stephen; Bali, Priti; Foote, Jeffrey; Deluca, Alexander

    2003-01-01

    The study examined the convergent validity of the ASAM Patient Placement Criteria (PPC) by comparing Level of Care (LOC) recommendations produced by two alternative methods: a computerdriven algorithm and a "standard" clinical assessment. A cohort of 248 applicants for alcoholism treatment were evaluated at a multi-modality treatment center. The two methods disagreed (58% of cases) more often than they agreed (42%). The algorithm recommended a more intense LOC than the clinician protocol in 81% of the discrepant cases. Four categories of disagreement accounted for 97% of the discrepant cases. Several major sources of disagreement were identified and examined in detail: clinicians' reasoned departures from the PPC rules, conservatism in algorithm LOC recommendations, and measurement overlap between two specific dimensions. In order for the ASAM PPC and its associated algorithm to be embraced by treatment programs, the observed differences in LOC recommendations between the algorithm and "standard" clinical assessment should be resolved.

  20. Convergent validity of K-SADS-PL by comparison with CBCL in a Portuguese speaking outpatient population

    Directory of Open Access Journals (Sweden)

    Bordin Isabel A

    2010-10-01

    Full Text Available Abstract Background Different diagnostic interviews in child and adolescent psychiatry have been developed in English but valid translations of instruments to other languages are still scarce especially in developing countries, limiting the comparison of child mental health data across different cultures. The present study aims to examine the convergent validity of the Brazilian version of the Schedule for Affective Disorders and Schizophrenia for School-Age Children/Present and Lifetime Version (K-SADS-PL by comparison with the Child Behavior Checklist (CBCL, a parental screening measure for child/adolescent emotional/behavior problems. Methods An experienced child psychiatrist blind to CBCL results applied the K-SADS-PL to a consecutive sample of 78 children (6-14 years referred to a public child mental health outpatient clinic (response rate = 75%. Three K-SADS-PL parameters were considered regarding current disorders: parent screen interview rates, clinician summary screen interview rates, and final DSM-IV diagnoses. Subjects were classified according to the presence/absence of any affective/anxiety disorder, any disruptive disorder, and any psychiatric disorder based on K-SADS-PL results. All subjects obtained T-scores on CBCL scales (internalizing, externalizing, total problems. Results Significant differences in CBCL mean T-scores were observed between disordered and non-disordered children. Compared to children who screened negative, children positive for any affective/anxiety disorder, any disruptive disorder, and any psychiatric disorder had a higher internalizing, externalizing and total problem T-score mean, respectively. Highly significant differences in T-score means were also found when examining final diagnoses, except for any affective/anxiety disorder. Conclusions Evidence of convergent validity was found when comparing K-SADS-PL results with CBCL data.

  1. The Convergent, Discriminant, and Concurrent Validity of Scores on the Abbreviated Self-Leadership Questionnaire

    Directory of Open Access Journals (Sweden)

    Faruk Şahin

    2015-10-01

    Full Text Available The present study reports the psychometric properties of a short measure of self-leadership in the Turkish context: the Abbreviated Self-Leadership Questionnaire (ASLQ. The ASLQ was examined using two samples and showed sound psychometric properties. Confirmatory factor analysis showed that nine-item ASLQ measured a single construct of self-leadership. The results supported the convergent and discriminant validity of the one-factor model of the ASLQ in relation to the 35-item Revised Self-Leadership Questionnaire and General Self-Efficacy scale, respectively. With regard to internal consistency and test-retest reliability, the ASLQ showed acceptable results. Furthermore, the results provided evidence that scores on the ASLQ positively predicted individual's self-reported task performance and self-efficacy mediated this relationship. Taken together, these findings suggest that the Turkish version of the ASLQ is a reliable and valid measure that can be used to measure self-leadership as one variable of interest in the future studies.

  2. The general environment fit scale: a factor analysis and test of convergent construct validity.

    Science.gov (United States)

    Beasley, Christopher R; Jason, Leonard A; Miller, Steven A

    2012-09-01

    Person-environment fit (P-E fit) was initially espoused as an important construct in the field of community psychology; however, most of the theoretical and empirical development of the construct has been conducted by the industrial/organizational (I/O) psychologists and business management fields. In the current study, the GEFS-a P-E fit measure that was developed from organizational perspectives on fit-was administered to 246 attendees of an annual convention for residents and alumni of Oxford House, a network of over 1,400 mutual-help addiction recovery homes. The authors conducted confirmatory factor and convergent construct validity analyses with the GEFS. The results suggested that the theoretical factor structure of the measure adequately fit the data and provided limited support for the measure's validity. Sufficient supply of resident needs by the Oxford House and similarity between residents and their housemates predicted satisfaction with the recovery home, but only perceived similarity to housemates predicted how long residents intended to stay in the Oxford Houses.

  3. Large-Scale Investigation of the Role of Trait Activation Theory for Understanding Assessment Center Convergent and Discriminant Validity

    Science.gov (United States)

    Lievens, Filip; Chasteen, Christopher S.; Day, Eric Anthony; Christiansen, Neil D.

    2006-01-01

    This study used trait activation theory as a theoretical framework to conduct a large-scale test of the interactionist explanation of the convergent and discriminant validity findings obtained in assessment centers. Trait activation theory specifies the conditions in which cross-situationally consistent and inconsistent candidate performances are…

  4. Four broad temperament dimensions: description, convergent validation correlations, and comparison with the Big Five.

    Science.gov (United States)

    Fisher, Helen E; Island, Heide D; Rich, Jonathan; Marchalik, Daniel; Brown, Lucy L

    2015-01-01

    A new temperament construct based on recent brain physiology literature has been investigated using the Fisher Temperament Inventory (FTI). Four collections of behaviors emerged, each associated with a specific neural system: the dopamine, serotonin, testosterone, and estrogen/oxytocin system. These four temperament suites have been designated: (1) Curious/Energetic, (2) Cautious/Social Norm Compliant, (3) Analytical/Tough-minded, and (4) Prosocial/Empathetic temperament dimensions. Two functional magnetic resonance imaging (fMRI) studies have suggested that the FTI can measure the influence of these neural systems. In this paper, to further the behavioral validation and characterization of the four proposed temperament dimensions, we measured correlations with five variables: (1) gender; (2) level of education; (3) religious preference; (4) political orientation; (5) the degree to which an individual regards sex as essential to a successful relationship. Subjects were 39,913 anonymous members of a US Internet dating site and 70,000+ members in six other countries. Correlations with the five variables characterize the FTI and are consistent with mechanisms using the proposed neuromodulators. We also report on an analysis between the FTI and the NEO-Five Factor Inventory, using a college sample (n = 215), which showed convergent validity. The results provide novel correlates not available in other questionnaires: religiosity, political orientation, and attitudes about sex in a relationship. Also, an Eigen analysis replicated the four clusters of co-varying items. The FTI, with its broad systems and non-pathologic factors complements existing personality questionnaires. It provides an index of some brain systems that contribute to temperament, and may be useful in psychotherapy, business, medicine, and the legal community.

  5. Four broad temperament dimensions: Description, convergent validation correlations, and comparison with the Big Five

    Directory of Open Access Journals (Sweden)

    Helen eFisher

    2015-08-01

    Full Text Available A new temperament construct based on recent brain physiology literature has been investigated using the Fisher Temperament Inventory (FTI. Four collections of behaviors emerged, each associated with a specific neural system: the dopamine, serotonin, testosterone and estrogen/oxytocin system. These four temperament suites have been designated: 1 Curious/Energetic, 2 Cautious/Social Norm Compliant, 3 Analytical/Tough-minded, and 4 Prosocial/Empathetic temperament dimensions. Two functional magnetic resonance imaging (fMRI studies have suggested that the FTI can measure the influence of these neural systems. In this paper, to further the behavioral validation and characterization of the four proposed temperament dimensions, we measured correlations with five variables: 1 gender; 2 level of education; 3 religious preference; 4 political orientation; 5 the degree to which an individual regards sex as essential to a successful relationship. Subjects were 39,913 anonymous members of a US Internet dating site and 70,000+ members in six other countries. Correlations with the five variables characterize the Fisher Temperament Inventory and are consistent with mechanisms using the proposed neuromodulators. We also report on an analysis between the FTI and the NEO-Five Factor Inventory, using a college sample (n=215, which showed convergent validity. The results provide novel correlates not available in other questionnaires: religiosity, political orientation and attitudes about sex in a relationship. Also, an Eigen analysis replicated the four clusters of co-varying items. The FTI, with its broad systems and non-pathologic factors complements existing personality questionnaires. It provides an index of some brain systems that contribute to temperament, and may be useful in psychotherapy, business, medicine, and the legal community.

  6. Screening symptoms of reactive attachment disorder: evidence for measurement invariance and convergent validity.

    Science.gov (United States)

    Vervoort, Eleonora; De Schipper, J Clasien; Bosmans, Guy; Verschueren, Karine

    2013-09-01

    The Relationship Problems Questionnaire (RPQ) was developed to screen symptoms of the inhibited and disinhibited subtype of reactive attachment disorder (RAD). This study further examines the psychometric properties of the RPQ in children with severe emotional and behavioural problems by testing its measurement invariance across informants and its convergent validity. Parents and teachers of 152 children [mean age (Mage) = 7.92] from 20 schools for special education filled out the RPQ and the Strengths and Difficulties Questionnaire (SDQ). During a home visit in a subsample of 77 children the Disturbances of Attachment Interview (DAI) was administered to the caregiver and the child was observed using an observational schedule for RAD. Exploratory and confirmatory factor analyses revealed the expected two-factor structure for both parent and teacher RPQ. Configural and metric invariance, but no scalar invariance, were obtained across informants. Both RPQ-subscales had acceptable to good internal consistencies and correlated as expected with similar DAI-subscales. Furthermore, the disinhibited RPQ-scale related with observations of the child's approach to a stranger. Finally, significant associations were found between the RPQ and the SDQ. Overall, the RPQ has good psychometric qualities as a multi-informant instrument for RAD-symptoms in children with severe emotional and behavioural problems.

  7. Generation of highly symmetric, cylindrically convergent shockwaves in water

    Science.gov (United States)

    Bland, S. N.; Krasik, Ya. E.; Yanuka, D.; Gardner, R.; MacDonald, J.; Virozub, A.; Efimov, S.; Gleizer, S.; Chaturvedi, N.

    2017-08-01

    We report on pulsed power driven, exploding copper wire array experiments conducted to generate cylindrical convergent shockwaves in water employing μs risetime currents >550 kA in amplitude and with stored energies of >15 kJ—a substantial increase over previous results. The experiments were carried out on the recently constructed Mega-Ampere-Compression-and-Hydrodynamics facility at Imperial College London in collaboration with colleagues of Technion, Israel. 10 mm diameter arrays consisting of 60 × 130 μm wires were utilized, and the current and voltage diagnostics of the load region suggested that ˜8 kJ of energy was deposited in the wires (and the load region close to the wires) during the experiments, resulting in the formation of dense, highly resistive plasmas that rapidly expanded driving the shockwaves in water. Laser-backlit framing images of the shockfront were obtained at radii 50:1. Framing images and streak photographs showed that the velocity of the shockwave reached ˜7.5 km s-1 at 0.1 mm from the axis. 2D hydrodynamic simulations that match the experimentally obtained implosion trajectory suggest that pressures >1 Mbar are produced within 10 μm of the axis along with water densities of 3gcm-3 and temperatures of many 1000 s of Kelvin. Under these conditions, Quotidian Equation of State suggests that a strongly coupled plasma with an ionization fraction of ˜0.7 would be formed. The results represent a "stepping stone" in the application of the technique to drive different material samples into high pressure, warm dense matter regimes with compact, university scale generators, and provide support in scaling the technique to multi-mega ampere currents.

  8. Convergency analysis of the high-order mimetic finite difference method

    Energy Technology Data Exchange (ETDEWEB)

    Lipnikov, Konstantin [Los Alamos National Laboratory; Veiga Da Beirao, L [UNIV DEGLI STUDI; Manzini, G [NON LANL

    2008-01-01

    We prove second-order convergence of the conservative variable and its flux in the high-order MFD method. The convergence results are proved for unstructured polyhedral meshes and full tensor diffusion coefficients. For the case of non-constant coefficients, we also develop a new family of high-order MFD methods. Theoretical result are confirmed through numerical experiments.

  9. High-resolution velocimetry in energetic tidal currents using a convergent-beam acoustic Doppler profiler

    Energy Technology Data Exchange (ETDEWEB)

    Sellar, Brian [Univ. of Edinburgh, Scotland (United Kingdom); Harding, Samuel F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Richmond, Marshall C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-07-16

    An array of convergent acoustic Doppler velocimeters has been developed and tested for the high resolution measurement of three-dimensional tidal flow velocities in an energetic tidal site. This configuration has been developed to increase spatial resolution of velocity measurements in comparison to conventional acoustic Doppler profilers (ADPs) which characteristically use diverging acoustic beams emanating from a single instrument. This is achieved using converging acoustic beams with a sample volume at the focal point of 0.03 m3. The array is also able to simultaneously measure three-dimensional velocity components in a profile throughout the water column, and as such is referred to herein as a converging-beam acoustic Doppler profiler (CADP). Mid-depth profiling is achieved through integration of the sensor platform with the operational Alstom 1MW DeepGen-IV Tidal Turbine. This proof-of-concept paper outlines system configuration and comparison to measurements provided by co-installed reference instrumentation. Comparison of CADP to standard ADP velocity measurements reveals a mean difference of 8 mm/s, standard deviation of 18 mm/s, and order-of-magnitude reduction in realizable length-scale. CADP focal point measurements compared to a proximal single-beam reference show peak cross-correlation coefficient of 0.96 over 4.0 s averaging period and a 47% reduction in Doppler noise. The dual functionality of the CADP as a profiling instrument with a high resolution focal point make this configuration a unique and valuable advancement in underwater velocimetry enabling improved turbulence, resource and structural loading quantification and validation of numerical simulations. Alternative modes of operation have been implemented including noise-reducing bi-static sampling. Since waves are simultaneously measured it is expected that derivatives of this system will be a powerful tool in wave-current interaction studies.

  10. Convergent Validity of the One-Mile Run and PACER VO2MAX Prediction Models in Middle School Students

    Directory of Open Access Journals (Sweden)

    Ryan D. Burns

    2014-02-01

    Full Text Available FITNESSGRAM uses an equating method to convert Progressive Aerobic Cardiovascular Endurance Run (PACER laps to One-mile run/walk (1MRW times to estimate aerobic fitness (VO2MAX in children. However, other prediction models can more directly estimate VO2MAX from PACER performance. The purpose of this study was to examine the convergent validity and relative accuracy between 1MRW and various PACER models for predicting VO2MAX in middle school students. Aerobic fitness was assessed on 134 students utilizing the 1MRW and PACER on separate testing days. Pearson correlations, Bland–Altman plots, kappa statistics, proportion of agreement, and prediction error were used to assess associations and agreement among models. Correlation coefficients were strong (r ≥ .80, p .40 and agreement > .90. The results support that PACER models contain convergent validity and strong relative accuracy with the 1MRW model.

  11. Translation and validation of Convergence Insufficiency Symptom Survey (CISS to Portuguese - psychometric results

    Directory of Open Access Journals (Sweden)

    Catarina Tavares

    2014-01-01

    Full Text Available Purpose: Translate and adapt the Convergence Insuficiency Symptom Survey (CISS questionnaire to the Portuguese language and culture and assess the psychometric properties of the translated questionnaire (CISSvp. Methods: The CISS questionnaire was adapted according to the methodology recommended by some authors. The process involved two translations and back-translations performed by independent evaluators, evaluation of these versions, preparation of a synthesis version and its pre-test. The final version (CISSvp was applied in 70 patients (21.79 ± 2.42 years students in higher education, and at two different times, by two observers, to assess its reliability. Results: The results showed good internal consistency of the CISSvp (Cronbach's alpha - α=0.893. The test re-test revealed an average of the differences between the first and second evaluation of 0.75 points (SD ± 3.53, which indicates a minimum bias between the two administrations. The interrater reliability assessed by intraclass correlation coefficient ranged from 0.880 to 0.952, revealing that the CISSvp represents an appropriate tool for measuring the visual discomfort associated with near vision tasks with a high level of reproducibility. Conclusions: The CISS Portuguese version, showed good psychometric properties and has been sown to be applicable to the Portuguese population, to quantify the visual discomfort associated with near vision, in higher education students.

  12. Thermal metamaterial for convergent transfer of conductive heat with high efficiency

    Science.gov (United States)

    Shen, Xiangying; Jiang, Chaoran; Li, Ying; Huang, Jiping

    2016-11-01

    It is crucially important to focus conductive heat in an efficient way, which has received much attention in energy science (say, solar cells), but is still far from being satisfactory due to the diffusive (divergent) nature of the heat. By developing a theory with hybrid transformations (rotation and stretch-compression), here we provide theoretical and experimental evidences for a type of thermal metamaterial called thermal converger. The converger is capable of convergently conducting heat in contrast to the known divergent behavior of heat diffusion, thus yielding a large heating region with high temperatures close to the heat source (high efficiency). The thermal converger further allows us to design a thermal grating—a thermal counterpart of optical grating. This work has relevance to heat focus with high efficiency, and it offers guidance both for efficient heat transfer and for designing thermal-converger-like metamaterials in other fields, such as electrics/magnetics, electromagnetics/optics, acoustics, and particle diffusion.

  13. Highly stable and routinely convergent 2-dimensional hydrodynamic device simulation

    Science.gov (United States)

    Lin, Qi; Goldsman, Neil; Tai, Gwo-Chung

    1994-02-01

    This paper presents a new method for solving the hydrodynamic (HD) model in submicron semiconductor device simulation. The main feature of this method is that the Poisson, current-continuity and energy-balance equations in the HD model are all expressed in self-adjoint forms through a set of new Slotboom-like variables. As a consequence, the discretization results in a system of finite-difference equations with a diagonally dominant coefficient matrix for each HD equation. The simultaneous HD equations are decoupled by using the Gummel block iteration method. To solve each equation, a fixed-point iteration technique is employed which explicitly updates the state variables at each spatial mesh-point. In addition to avoiding direct solution of large matrix equations, the diagonal dominance guarantees that each HD equation will converge for any initial value. We demonstrate the method by simulating a 2-D submicron MOSFET, and by comparison with Monte Carlo calculations. Excellent numerical convergence, stability, and efficiency are observed.

  14. Sensory outcome with nonsurgical management of esotropia with convergence excess (a high accommodative convergence/accommodation ratio).

    Science.gov (United States)

    Pratt-Johnson, J A; Tillson, G

    1984-08-01

    Twenty-seven patients with esotropia and convergence excess (a high accommodative convergence/accommodation [AC/A] ratio) managed nonsurgically underwent a final standardized evaluation of their sensory and motor status after a follow-up period of at least 8 years. All had a deviation with distance fixation of less than 10 prism dioptres (PD) of esotropia with full optical correction both initially and throughout the follow-up period. The average spherical-equivalent refractive error was +2.3 D. The AC/A ratio had tended to decrease with age, and most patients had fusion, although only a small proportion had central fusion and stereopsis. Approximately half of the patients had been treated with bifocals, but their sensory outcome did not differ from that of the other patients. Miotics had not been used for more than a few months in any patient, as they were ineffective in reducing the deviation with near fixation to less than 10 PD of esotropia. A study, possibly a multicentre one, involving larger numbers of patients should be designed to find out whether bifocal therapy offers an advantage in the final sensory outcome of such patients.

  15. Comparing the nine-item Shared Decision-Making Questionnaire to the OPTION Scale - an attempt to establish convergent validity.

    Science.gov (United States)

    Scholl, Isabelle; Kriston, Levente; Dirmaier, Jörg; Härter, Martin

    2015-02-01

    While there has been a clear move towards shared decision-making (SDM) in the last few years, the measurement of SDM-related constructs remains challenging. There has been a call for further psychometric testing of known scales, especially regarding validity aspects. To test convergent validity of the nine-item Shared Decision-Making Questionnaire (SDM-Q-9) by comparing it to the OPTION Scale. Cross-sectional study. Data were collected in outpatient care practices. Patients suffering from chronic diseases and facing a medical decision were included in the study. Consultations were evaluated using the OPTION Scale. Patients completed the SDM-Q-9 after the consultation. First, the internal consistency of both scales and the inter-rater reliability of the OPTION Scale were calculated. To analyse the convergent validity of the SDM-Q-9, correlation between the patient (SDM-Q-9) and expert ratings (OPTION Scale) was calculated. A total of 21 physicians provided analysable data of consultations with 63 patients. Analyses revealed good internal consistency of the SDM-Q-9 and limited internal consistency of the OPTION Scale. Inter-rater reliability of the latter was less than optimal. Association between the total scores of both instruments was weak with a Spearman correlation of r = 0.19 and did not reach statistical significance. By the use of the OPTION Scale convergent validity of the SDM-Q-9 could not be established. Several possible explanations for this result are discussed. This study shows that the measurement of SDM remains challenging. © 2012 John Wiley & Sons Ltd.

  16. Designing highly flexible and usable cyberinfrastructures for convergence.

    Science.gov (United States)

    Herr, Bruce W; Huang, Weixia; Penumarthy, Shashikant; Börner, Katy

    2006-12-01

    This article presents the results of a 7-year-long quest into the development of a "dream tool" for our research in information science and scientometrics and more recently, network science. The results are two cyberinfrastructures (CI): The Cyberinfrastructure for Information Visualization and the Network Workbench that enjoy a growing national and interdisciplinary user community. Both CIs use the cyberinfrastructure shell (CIShell) software specification, which defines interfaces between data sets and algorithms/services and provides a means to bundle them into powerful tools and (Web) services. In fact, CIShell might be our major contribution to progress in convergence. Just as Wikipedia is an "empty shell" that empowers lay persons to share text, a CIShell implementation is an "empty shell" that empowers user communities to plug-and-play, share, compare and combine data sets, algorithms, and compute resources across national and disciplinary boundaries. It is argued here that CIs will not only transform the way science is conducted but also will play a major role in the diffusion of expertise, data sets, algorithms, and technologies across multiple disciplines and business sectors leading to a more integrative science.

  17. Concurrent and Convergent Validity of the Eating in the Absence of Hunger Questionnaire and Behavioral Paradigm in Overweight Children

    Science.gov (United States)

    Madowitz, Jennifer; Liang, June; Peterson, Carol B.; Rydell, Sarah; Zucker, Nancy L.; Tanofsky-Kraff, Marian; Harnack, Lisa; Boutelle, Kerri N.

    2014-01-01

    Objective This study aimed to assess the concurrent and convergent validity of the Eating in the Absence of Hunger (EAH) questionnaire parent report of child (EAH-PC) and child self-report (EAH-C) with the EAH behavioral paradigm (EAH%) and usual dietary intake. Method Data were obtained at baseline assessment for 117 treatment-seeking overweight and obese (BMI > 85th percentile) 8- to 12-year old children (53% female, 54% white) and their parents. Children participated in the EAH free access paradigm after a standardized ad libitum meal. Parents and children completed EAH questionnaires, and the children completed three 24 h recalls. EAH External Eating subscale and total scores were assessed. Results EAH% was inversely associated with the EAH-PC total score (p < .04), however, it was not associated with the EAH-PC External Eating scale, EAH-C total score or EAH-C External Eating scale. Daily caloric intake was positively related to both the EAH-C total score (p < .02) and External Eating subscale (p < .007). Daily caloric intake was inversely related to EAH-PC total score (p < .05), but was not related to EAH-PC External Eating subscale or EAH%. Discussion Concurrent validity was not supported for EAH questionnaires, but convergent validity was supported for EAH-C and child daily caloric intake. Further research is warranted to assess whether EAH questionnaires and paradigm are measuring different aspects of EAH in treatment-seeking children. PMID:24186043

  18. The Trait Emotional Intelligence Questionnaire: Internal Structure, Convergent, Criterion, and Incremental Validity in an Italian Sample

    Science.gov (United States)

    Andrei, Federica; Smith, Martin M.; Surcinelli, Paola; Baldaro, Bruno; Saklofske, Donald H.

    2016-01-01

    This study investigated the structure and validity of the Italian translation of the Trait Emotional Intelligence Questionnaire. Data were self-reported from 227 participants. Confirmatory factor analysis supported the four-factor structure of the scale. Hierarchical regressions also demonstrated its incremental validity beyond demographics, the…

  19. The Trait Emotional Intelligence Questionnaire: Internal Structure, Convergent, Criterion, and Incremental Validity in an Italian Sample

    Science.gov (United States)

    Andrei, Federica; Smith, Martin M.; Surcinelli, Paola; Baldaro, Bruno; Saklofske, Donald H.

    2016-01-01

    This study investigated the structure and validity of the Italian translation of the Trait Emotional Intelligence Questionnaire. Data were self-reported from 227 participants. Confirmatory factor analysis supported the four-factor structure of the scale. Hierarchical regressions also demonstrated its incremental validity beyond demographics, the…

  20. Convergence among Data Sources, Response Bias, and Reliability and Validity of a Structured Job Analysis Questionnaire.

    Science.gov (United States)

    Smith, Jack E.; Hakel, Milton D.

    1979-01-01

    Examined are questions pertinent to the use of the Position Analysis Questionnaire: Who can use the PAQ reliably and validly? Must one rely on trained job analysts? Can people having no direct contact with the job use the PAQ reliably and validly? Do response biases influence PAQ responses? (Author/KC)

  1. Further evaluation of the construct, convergent and criterion validity of the Gambling Urge Scale with university-student gamblers.

    Science.gov (United States)

    Ashrafioun, Lisham; Rosenberg, Harold; Cross, Nicole A; Brian, Thomas J

    2013-09-01

    Research has documented the prevalence of problem gambling among university students, and craving is one factor that may provoke and maintain episodes of gambling. We designed this study to assess elements of construct, convergent and criterion validity of the Gambling Urge Scale (GUS) when administered to regularly gambling university students. Students (n = 250) recruited from three universities during the spring semester, 2012, were randomly assigned to one of four conditions to test the impact of cue exposure to one of two types of stimuli (gambling versus non-gambling activity), and two types of presentation format (photographic versus imagery scripts), on current craving to gamble. Self-reported craving increased significantly following exposure to gambling cues, but not following exposure to engaging non-gambling cues, regardless of the format by which cues were presented. Among those exposed to gambling cues, GUS craving scores were significantly correlated with all three subscales of another measure of craving to gamble, gambling-related problems, passionate attachment to gambling, distorted gambling beliefs and gambling refusal self-efficacy. These findings provide further support for the construct, convergent and criterion validity of the GUS as a measure of subjective craving in university student gamblers.

  2. Motor competence assessment in children: convergent and discriminant validity between the BOT-2 Short Form and KTK testing batteries.

    Science.gov (United States)

    Fransen, Job; D'Hondt, Eva; Bourgois, Jan; Vaeyens, Roel; Philippaerts, Renaat M; Lenoir, Matthieu

    2014-06-01

    This study investigated convergent and discriminant validity between two motor competence assessment instruments in 2485 Flemish children: the Bruininks-Oseretsky Test of Motor Proficiency 2 Short Form (BOT-2 Short Form) and the KörperKoördinationsTest für Kinder (KTK). A Pearson correlation assessed the relationship between BOT-2 Short Form total, gross and fine motor composite scores and KTK Motor Quotient in three age cohorts (6-7, 8-9, 10-11 years). Crosstabs were used to measure agreement in classification in children scoring below percentile 5 and 15 and above percentile 85 and 95. Moderately strong positive (r=0.44-0.64) associations between BOT-2 total and gross motor composite scores and KTK Motor Quotient and weak positive correlations between BOT-2 Short Form fine motor composite and KTK Motor Quotient scores (r=0.25-0.37) were found. Levels of agreement were fair to moderate. Therefore, some proof of convergent and discriminant validity between BOT-2 Short Form and KTK was established in this study, underlining the notion that the evaluation of motor competence should not be based upon a single assessment instrument.

  3. The Achilles tendon total rupture score: a study of responsiveness, internal consistency and convergent validity on patients with acute Achilles tendon ruptures

    Directory of Open Access Journals (Sweden)

    Kearney Rebecca S

    2012-02-01

    Full Text Available Abstract Background The Achilles tendon Total Rupture Score was developed by a research group in 2007 in response to the need for a patient reported outcome measure for this patient population. Beyond this original development paper, no further validation studies have been published. Consequently the purpose of this study was to evaluate internal consistency, convergent validity and responsiveness of this newly developed patient reported outcome measure within patients who have sustained an isolated acute Achilles tendon rupture. Methods Sixty-four eligible patients with an acute rupture of their Achilles tendon completed the Achilles tendon Total Rupture Score alongside two further patient reported outcome measures (Disability Rating Index and EQ 5D. These were completed at baseline, six weeks, three months, six months and nine months post injury. The Achilles tendon Total Rupture Score was evaluated for internal consistency, using Cronbach's alpha, convergent validity, through correlation analysis and responsiveness, by analysing floor and ceiling effects and calculating its relative efficiency in comparison to the Disability Rating Index and EQ 5D scores. Results The Achilles tendon Total Rupture Score demonstrated high internal consistency (Cronbachs alpha > 0.8 and correlated significantly (p Conclusions A universally accepted outcome measure is imperative to allow comparisons to be made across practice. This is the first study to evaluate aspects of validity of this newly developed outcome measure, outside of the developing centre. The ATRS demonstrated high internal consistency and responsiveness, with limited convergent validity. This research provides further support for the use of this outcome measure, however further research is required to advocate its universal use in patients with acute Achilles tendon ruptures. Such areas include inter-rater reliability and research to determine the minimally clinically important difference

  4. The Achilles tendon total rupture score: a study of responsiveness, internal consistency and convergent validity on patients with acute Achilles tendon ruptures.

    Science.gov (United States)

    Kearney, Rebecca S; Achten, Juul; Lamb, Sarah E; Parsons, Nicholas; Costa, Matthew L

    2012-02-29

    The Achilles tendon Total Rupture Score was developed by a research group in 2007 in response to the need for a patient reported outcome measure for this patient population. Beyond this original development paper, no further validation studies have been published.Consequently the purpose of this study was to evaluate internal consistency, convergent validity and responsiveness of this newly developed patient reported outcome measure within patients who have sustained an isolated acute Achilles tendon rupture. Sixty-four eligible patients with an acute rupture of their Achilles tendon completed the Achilles tendon Total Rupture Score alongside two further patient reported outcome measures (Disability Rating Index and EQ 5D). These were completed at baseline, six weeks, three months, six months and nine months post injury. The Achilles tendon Total Rupture Score was evaluated for internal consistency, using Cronbach's alpha, convergent validity, through correlation analysis and responsiveness, by analysing floor and ceiling effects and calculating its relative efficiency in comparison to the Disability Rating Index and EQ 5D scores. The Achilles tendon Total Rupture Score demonstrated high internal consistency (Cronbachs alpha > 0.8) and correlated significantly (p measure is imperative to allow comparisons to be made across practice. This is the first study to evaluate aspects of validity of this newly developed outcome measure, outside of the developing centre. The ATRS demonstrated high internal consistency and responsiveness, with limited convergent validity. This research provides further support for the use of this outcome measure, however further research is required to advocate its universal use in patients with acute Achilles tendon ruptures. Such areas include inter-rater reliability and research to determine the minimally clinically important difference between scores.All authors have read and concur with the content of this manuscript. The material

  5. Convergent evolution of complex brains and high intelligence.

    Science.gov (United States)

    Roth, Gerhard

    2015-12-19

    Within the animal kingdom, complex brains and high intelligence have evolved several to many times independently, e.g. among ecdysozoans in some groups of insects (e.g. blattoid, dipteran, hymenopteran taxa), among lophotrochozoans in octopodid molluscs, among vertebrates in teleosts (e.g. cichlids), corvid and psittacid birds, and cetaceans, elephants and primates. High levels of intelligence are invariantly bound to multimodal centres such as the mushroom bodies in insects, the vertical lobe in octopodids, the pallium in birds and the cerebral cortex in primates, all of which contain highly ordered associative neuronal networks. The driving forces for high intelligence may vary among the mentioned taxa, e.g. needs for spatial learning and foraging strategies in insects and cephalopods, for social learning in cichlids, instrumental learning and spatial orientation in birds and social as well as instrumental learning in primates.

  6. Convergent polishing: a simple, rapid, full aperture polishing process of high quality optical flats & spheres.

    Science.gov (United States)

    Suratwala, Tayyab; Steele, Rusty; Feit, Michael; Dylla-Spears, Rebecca; Desjardin, Richard; Mason, Dan; Wong, Lana; Geraghty, Paul; Miller, Phil; Shen, Nan

    2014-12-01

    Convergent Polishing is a novel polishing system and method for finishing flat and spherical glass optics in which a workpiece, independent of its initial shape (i.e., surface figure), will converge to final surface figure with excellent surface quality under a fixed, unchanging set of polishing parameters in a single polishing iteration. In contrast, conventional full aperture polishing methods require multiple, often long, iterative cycles involving polishing, metrology and process changes to achieve the desired surface figure. The Convergent Polishing process is based on the concept of workpiece-lap height mismatch resulting in pressure differential that decreases with removal and results in the workpiece converging to the shape of the lap. The successful implementation of the Convergent Polishing process is a result of the combination of a number of technologies to remove all sources of non-uniform spatial material removal (except for workpiece-lap mismatch) for surface figure convergence and to reduce the number of rogue particles in the system for low scratch densities and low roughness. The Convergent Polishing process has been demonstrated for the fabrication of both flats and spheres of various shapes, sizes, and aspect ratios on various glass materials. The practical impact is that high quality optical components can be fabricated more rapidly, more repeatedly, with less metrology, and with less labor, resulting in lower unit costs. In this study, the Convergent Polishing protocol is specifically described for fabricating 26.5 cm square fused silica flats from a fine ground surface to a polished ~λ/2 surface figure after polishing 4 hr per surface on a 81 cm diameter polisher.

  7. The discriminant (and convergent) validity of the Personality Inventory for DSM-5.

    Science.gov (United States)

    Crego, Cristina; Gore, Whitney L; Rojas, Stephanie L; Widiger, Thomas A

    2015-10-01

    A considerable body of research has rapidly accumulated with respect to the validity of the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) dimensional trait model as it is assessed by the Personality Inventory for Diagnostic and Statistical Manual of Mental Disorders (PID-5; Krueger et al., 2012). This research though has not focused specifically on discriminant validity, although allusions to potentially problematic discriminant validity have been raised. The current study addressed discriminant validity, reporting for the first time the correlations among the PID-5 domain scales. Also reported are the bivariate correlations of the 25 PID-5 maladaptive trait scales with the personality domain scales of the NEO Personality Inventory-Revised (Costa & McCrae, 1992), the International Personality Item Pool-NEO (Goldberg et al., 2006), the Inventory of Personal Characteristics (Almagor et al., 1995), the 5-Dimensional Personality Test (van Kampen, 2012), and the HEXACO Personality Inventory-Revised (Lee & Ashton, 2004). The results are discussed with respect to the implications of and alternative explanations for potentially problematic discriminant validity. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  8. High-resolution modeling of indirectly driven high-convergence layered inertial confinement fusion capsule implosions

    Science.gov (United States)

    Haines, Brian M.; Aldrich, C. H.; Campbell, J. M.; Rauenzahn, R. M.; Wingate, C. A.

    2017-05-01

    In this paper, we present the results of high-resolution simulations of the implosion of high-convergence layered indirect-drive inertial confinement fusion capsules of the type fielded on the National Ignition Facility using the xRAGE radiation-hydrodynamics code. In order to evaluate the suitability of xRAGE to model such experiments, we benchmark simulation results against available experimental data, including shock-timing, shock-velocity, and shell trajectory data, as well as hydrodynamic instability growth rates. We discuss the code improvements that were necessary in order to achieve favorable comparisons with these data. Due to its use of adaptive mesh refinement and Eulerian hydrodynamics, xRAGE is particularly well suited for high-resolution study of multi-scale engineering features such as the capsule support tent and fill tube, which are known to impact the performance of high-convergence capsule implosions. High-resolution two-dimensional (2D) simulations including accurate and well-resolved models for the capsule fill tube, support tent, drive asymmetry, and capsule surface roughness are presented. These asymmetry seeds are isolated in order to study their relative importance and the resolution of the simulations enables the observation of details that have not been previously reported. We analyze simulation results to determine how the different asymmetries affect hotspot reactivity, confinement, and confinement time and how these combine to degrade yield. Yield degradation associated with the tent occurs largely through decreased reactivity due to the escape of hot fuel mass from the hotspot. Drive asymmetries and the fill tube, however, degrade yield primarily via burn truncation, as associated instability growth accelerates the disassembly of the hotspot. Modeling all of these asymmetries together in 2D leads to improved agreement with experiment but falls short of explaining the experimentally observed yield degradation, consistent with previous

  9. Convergence and low temperature adaptability analysis of the high temperature series expansion of the free energy.

    Science.gov (United States)

    Zhou, Shiqi

    2013-09-28

    By appealing to the coupling parameter series expansion to calculate the first seven perturbation coefficients of the high temperature series expansion (HTSE) of the free energy, analysis of convergence and low temperature adaptability of the HTSE in calculating fluid thermodynamic properties is performed for the first time; the fluid thermodynamic properties considered include critical parameters, vapor-liquid coexistence curve, thermodynamic characteristic functions, chemical potential, pressure, and constant volume excess heat capacity. To proceed with the analysis, a well known square well model is used as sample; the well widths considered range over a wide interval, and the relevant temperatures amenable to simulation calculations (used as "exact" results to analyze the HTSE) can be both very high and very low. The main discoveries reached are summarized as follows: (1) The HTSE usually converges at the 4th-order truncation, but with decrease of the temperature considered, the lowest truncation order, which makes the HTSE to converge, tends to rise. As a conservative estimate, it is considered that the HTSE always converges for reduced temperature T* higher than 0.25, whereas for T* converges approximately to the correct solution, and the HTSE can be reliably used to calculate the fluid thermodynamic properties, and within this temperature interval, the 4th-order truncation is enough; whereas for T* converge, it does not converge to the correct solution, and the deviations between the HTSE calculations and MC simulations become an ever-prominent issue with the rising of the density, and the slopes of the thermodynamic properties over density are not satisfactorily represented. As a result, the HTSE is not suited for calculations for temperature interval T* < 0.5.

  10. Measures of Trait Mindfulness:Convergent Validity, Shared Dimensionality, and Linkages to the Five-Factor Model

    Directory of Open Access Journals (Sweden)

    A. B. Siegling

    2014-10-01

    Full Text Available This study investigated, and partially aimed to replicate, important construct validity aspects and the homogeneity of trait mindfulness measures. Specifically, the study set out to examine whether a single dimension can explain the shared variance among these measures as well as the extent to which they converge with one another and in terms of their linkages to the Five-Factor Model (FFM. Two samples completed all trait measures of the construct and one of them additionally completed a measure of the Big Five personality traits. Results showed that a single dimension explains the shared variance among measures based on the original, Eastern conceptualization of mindfulness, although not all of them seem to represent this construct comprehensively. Intercorrelations, dimensionality analysis, as well as linkages to the FFM indicated that the Eastern and Western conceptualizations, and their respective measures, reflect distinct constructs. However, the amount of variance overlap with the FFM was similar across the two conceptualizations.

  11. The convergent validity of three surveys as alternative sources of health information to the 2011 UK census.

    Science.gov (United States)

    Taylor, Joanna; Twigg, Liz; Moon, Graham

    2014-09-01

    Censuses have traditionally been a key source of localised information on the state of a nation's health. Many countries are now adopting alternative approaches to the traditional census, placing such information at risk. The purpose of this paper is to inform debate about whether existing social surveys could provide an adequate 'base' for alternative model-based small area estimates of health data in a post traditional census era. Using a case study of 2011 UK Census questions on self-assessed health and limiting long term illness, we examine the extent to which the results from three large-scale surveys - the Health Survey for England, the Crime Survey for England and Wales and the Integrated Household Survey - conform to census output. Particularly in the case of limiting long term illness, the question wording renders comparisons difficult. However, with the exception of the general health question from the Health Survey for England all three surveys meet tests for convergent validity.

  12. The molecular basis of convergence in hemoglobin function in high-altitude Andean birds

    DEFF Research Database (Denmark)

    Storz, Jay; Natarajan, Chandrasekhar; Witt, Christopher C.

    2016-01-01

    was correct that adaptive modifications of Hb function are typically attributable to a small number of substitutions at key positions, then the clear prediction is that the same mutations will be preferentially fixed in different species that have independently evolved Hbs with similar functional properties....... For example, in high-altitude ertebrates that have convergently evolved elevated Hb-O2 affinities, Perutz’s hypothesis predicts that parallel amino acid substitutions should be pervasive. We investigated the predictability of genetic adaptation by examining the molecular basis of convergence in hemoglobin (Hb...

  13. Convergent evolution towards high net carbon gain efficiency contributes to the shade tolerance of palms (Arecaceae)

    NARCIS (Netherlands)

    Ma, Ren Yi; Zhang, Jiao Lin; Cavaleri, Molly A.; Sterck, Frank; Strijk, J.S.; Cao, Kun Fang

    2015-01-01

    Most palm species occur in the shaded lower strata of tropical rain forests, but how their traits relate to shade adaptation is poorly understood. We hypothesized that palms are adapted to the shade of their native habitats by convergent evolution towards high net carbon gain efficiency (CGEn),

  14. Diffusion Patterns in Convergence among High-Technology Industries: A Co-Occurrence-Based Analysis of Newspaper Article Data

    Directory of Open Access Journals (Sweden)

    Hyeokseong Lee

    2016-10-01

    Full Text Available Firms in high-technology industries have faced great technological and market uncertainty and volatility in the past few decades. In order to be competitive and sustainable in this environment, firms have been pursuing technological innovation, product differentiation, vertical integration, and alliances, which eventually drive industry convergence, defined as the process of blurring boundaries between previously distinct industries. Although industry convergence has greatly affected industrial structure and the economy, little research has investigated this phenomenon, especially its diffusion patterns; thus, it is still unclear which industries are converging more rapidly or have a higher potential for convergence. This paper explores these issues by investigating industry convergence in U.S. high-technology industries, using a large set of newspaper articles from 1987 to 2012. We perform a co-occurrence-based analysis to obtain information on industry convergence and estimate its diffusion patterns using an internal-influence logistic model. We find heterogeneous diffusion patterns, depending on convergent-industry pairs and their wide dispersion. In addition, we find that the potential degree of industry convergence is significantly negatively associated with its growth rate, which indicates that a great deal of time will be required for industry convergence between high-technology industries with this high potential to achieve a high degree of convergence.

  15. Validation of two conceptualizations of fragile self-esteem: Contingent high self-esteem and incongruent high self-esteem

    OpenAIRE

    Bodroža Bojana

    2014-01-01

    The aim of this research was to validate two aspects of fragile high self-esteem: a combination of contingent and high (explicit) self-esteem and a combination of high explicit and low implicit self-esteem (i.e. incongruent high self-esteem), as well as to examine the relationship between these aspects of fragile self-esteem and narcissism. No convergence was found between contingent high and incongruent high self-esteem. The result was consistent regardles...

  16. The reliability and convergent and divergent validity of the Ruff Figural Fluency Test in healthy young adults.

    Science.gov (United States)

    Ross, Thomas P

    2014-12-01

    The reliability and validity of standard and qualitative scores for the Ruff Figural Fluency Test (RFFT; Ruff, 1988) was examined in 102 healthy undergraduates. Participants (M age = 21.79; SD = 3.7; age = 80% Caucasian) were administered the RFFT and measures assessing executive functions (EF) and other cognitive domains. Inter-scorer reliability was excellent (0.9 range) for most RFFT indices. Test-retest coefficients (M interval = 7 weeks) ranged from 0.64 for the error ratio score to 0.87 for unique designs. RFFT indices correlated with Block Design performance and nonverbal measures of working memory, but were unrelated to measures of verbal fluency, verbal learning, or working memory for verbal material. RFFT novel design output correlated with most measures of EF supporting the convergent validity of this measure. In contrast, correlations between measures of EF and qualitative scores were absent or weak. RFFT score interpretation is discussed in light of relevant models of EF and directions for future research are presented.

  17. Examining the factor structure and convergent and discriminant validity of the Levenson self-report psychopathy scale: is the two-factor model the best fitting model?

    Science.gov (United States)

    Salekin, Randall T; Chen, Debra R; Sellbom, Martin; Lester, Whitney S; MacDougall, Emily

    2014-07-01

    The Levenson, Kiehl, and Fitzpatrick (1995) Self-Report Psychopathy Scale (LSRP) was introduced in the mid-1990s as a brief measure of psychopathy and has since gained considerable popularity. Despite its attractiveness as a brief psychopathy tool, the LSRP has received limited research regarding its factor structure and convergent and discriminant validity. The present study examined the construct validity of the LSRP, testing both its factor structure and the convergent and discriminant validity. Using a community sample of 1,257 undergraduates (869 females; 378 males), we tested whether a 1-, 2-, or 3-factor model best fit the data and examined the links between the resultant factor structures and external correlates. Confirmatory factor analysis (CFA) findings revealed a 3-factor model best matched the data, followed by an adequate-fitting original 2-factor model. Next, comparisons were made regarding the convergent and discriminant validity of the competing 2- and 3-factor models. Findings showed the LSRP traditional primary and secondary factors had meaningful relations with extratest variables such as neuroticism, stress tolerance, and lack of empathy. The 3-factor model showed particular problems with the Callousness scale. These findings underscore the importance of examining not only CFA fit statistics but also convergent and discriminant validity when testing factor structure models. The current findings suggest that the 2-factor model might still be the best way to interpret the LSRP. (c) 2014 APA, all rights reserved.

  18. Discriminant and Convergent Validity of the Anxiety Construct in Children with Autism Spectrum Disorders

    Science.gov (United States)

    Renno, Patricia; Wood, Jeffrey J.

    2013-01-01

    Despite reports of high anxiety in children with autism spectrum disorders (ASD), there is controversy regarding differential diagnosis of ASD symptoms and anxiety symptoms. This study examined 88 children, aged 7-11 years, with ASD referred for concerns about anxiety. A multitrait-(social anxiety, separation anxiety, overall anxiety severity, and…

  19. Discriminant and Convergent Validity of the Anxiety Construct in Children with Autism Spectrum Disorders

    Science.gov (United States)

    Renno, Patricia; Wood, Jeffrey J.

    2013-01-01

    Despite reports of high anxiety in children with autism spectrum disorders (ASD), there is controversy regarding differential diagnosis of ASD symptoms and anxiety symptoms. This study examined 88 children, aged 7-11 years, with ASD referred for concerns about anxiety. A multitrait-(social anxiety, separation anxiety, overall anxiety severity, and…

  20. EVCP: a convergence time improved high-speed transport congestion control protocol

    Institute of Scientific and Technical Information of China (English)

    LU Guang; WANG Yong-chao; ZHU Miao-liang

    2007-01-01

    The Internet evolves to incorporate very-high-bandwidth optical links and more large-delay satellite links. TCP faces new challenges in this unique environment. Theory and experiments showed that TCP becomes inefficient and is prone to be unstable as the per-flow product of bandwidth and latency increases, regardless of the queuing scheme. Variable-structure congestion Control Protocol (VCP) is proposed to address these problems. However, VCP has problem in terms of convergence time,i.e., it takes a long time for a new VCP flow to achieve fair bandwidth allocation if the existing VCP flows have large congestion windows. This paper proposed an Extended Variable-structure congestion Control Protocol (EVCP), which adopted a convergence controller. The basic idea of convergence controller is that if a flow has larger window than its fair window, its congestion window should be decreased more aggressively than usual in Multiplicative Decrease (MD) phase. Simulations showed that EVCP has better performance in terms of convergence time while keeping the advantages of VCP.

  1. Fast global convergence of gradient methods for high-dimensional statistical recovery

    CERN Document Server

    Agarwal, Alekh; Wainwright, Martin J

    2011-01-01

    Many statistical M-estimators are based on convex optimization problems formed by the combination of a data-dependent loss function with a norm-based regularizer. We analyze the convergence rates of projected gradient methods for solving such problems, working within a high-dimensional framework that allows the data dimension d to grow with (and possibly exceed) the sample size n. This high-dimensional structure precludes the usual global assumptions---namely, strong convexity and smoothness conditions---that underlie much of classical optimization analysis. We define appropriately restricted versions of these conditions, and show that they are satisfied with high probability for various statistical models. Under these conditions, our theory guarantees that projected gradient descent has a globally geometric rate of convergence up to the \\emph{statistical precision} of the model, meaning the typical distance between the true unknown parameter $\\theta^*$ and an optimal solution $\\hat{\\theta}$. This result is s...

  2. Assessment of Childhood Social Phobia: Construct, Convergent and Discriminative Validity of the Social Phobia and Anxiety Inventory for Children (SPAI-C).

    Science.gov (United States)

    Beidel, Deborah C.; And Others

    1996-01-01

    The convergent validity of the SPAI-C was studied by comparing scores to daily diary ratings of social distress for 10 elementary school children with social phobia, 3 of whom had overanxious disorder, and 10 controls. Results support the ability of the SPAI-C to distinguish social phobic children. (SLD)

  3. Evaluation of the Criterion and Convergent Validity of the Diagnostic Interview for Social and Communication Disorders in Young and Low-Functioning Children

    Science.gov (United States)

    Maljaars, Jarymke; Noens, Ilse; Scholte, Evert; van Berckelaer-Onnes, Ina

    2012-01-01

    The Diagnostic Interview for Social and Communication Disorders (DISCO; Wing, 2006) is a standardized, semi-structured and interviewer-based schedule for diagnosis of autism spectrum disorder (ASD). The objective of this study was to evaluate the criterion and convergent validity of the DISCO-11 ICD-10 algorithm in young and low-functioning…

  4. Impact of Alzheimer's Disease on Caregiver Questionnaire: internal consistency, convergent validity, and test-retest reliability of a new measure for assessing caregiver burden.

    Science.gov (United States)

    Cole, Jason C; Ito, Diane; Chen, Yaozhu J; Cheng, Rebecca; Bolognese, Jennifer; Li-McLeod, Josephine

    2014-09-04

    unidimensional, Web-based measure of AD caregiver burden and is supported by strong model fit statistics from CFA, high degree of item-level reliability, good internal consistency, moderate test-retest reliability, and moderate convergent validity. Additional validation of the IADCQ is warranted to ensure invariance between the paper-based and Web-based administration and to determine an appropriate responder definition.

  5. Total synthesis of (+)-discodermolide: a highly convergent fourth-generation approach.

    Science.gov (United States)

    Smith, Amos B; Freeze, B Scott; Xian, Ming; Hirose, Tomoyasu

    2005-04-28

    [structure: see text] A highly convergent, fourth-generation total synthesis of (+)-discodermolide (1), with a longest linear sequence of 17 steps and an overall yield of 9.0%, has been achieved. Highlighting the strategy is the efficient construction and sequential, bidirectional union of a linchpin comprising the C(9)-C(14) Wittig salt-vinyl iodide (-)-18. Importantly, Wittig salt generation proceeded in excellent yield under ambient pressure.

  6. Solving radiative transfer problems in highly heterogeneous media via domain decomposition and convergence acceleration techniques.

    Science.gov (United States)

    Previti, Alberto; Furfaro, Roberto; Picca, Paolo; Ganapol, Barry D; Mostacci, Domiziano

    2011-08-01

    This paper deals with finding accurate solutions for photon transport problems in highly heterogeneous media fastly, efficiently and with modest memory resources. We propose an extended version of the analytical discrete ordinates method, coupled with domain decomposition-derived algorithms and non-linear convergence acceleration techniques. Numerical performances are evaluated using a challenging case study available in the literature. A study of accuracy versus computational time and memory requirements is reported for transport calculations that are relevant for remote sensing applications.

  7. Modeling high-grade serous carcinoma: how converging insights into pathogenesis and genetics are driving better experimental platforms

    Directory of Open Access Journals (Sweden)

    Paul Michael Jones

    2013-08-01

    Full Text Available Recent developments in the study of epithelial ovarian cancer have called into question the traditional views regarding the site of tumor initiation. Histopathologic studies and genomic analyses suggest that extra-ovarian sites, like the fallopian tube, may harbor the coveted cell of origin and could therefore contribute significantly to the development of high-grade serous ovarian carcinoma (HG-SOC. Our ability to validate these emerging genomic and pathologic observations and characterize the early transformation events of HG-SOC hinges on the development of novel model systems. Currently, there are only a handful of new model systems that are addressing these concerns. This review will chronicle the convergent evolution of these ovarian cancer model systems in the context of the changing pathologic and genomic understanding of HG-SOC.

  8. Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent.

    Science.gov (United States)

    Rubio-Garrido, Pablo; Pérez-de-Manzo, Flor; Porrero, César; Galazo, Maria J; Clascá, Francisco

    2009-10-01

    Input to apical dendritic tufts is now deemed crucial for associative learning, attention, and similar "feedback" interactions in the cerebral cortex. Excitatory input to apical tufts in neocortical layer 1 has been traditionally assumed to be predominantly cortical, as thalamic pathways directed to this layer were regarded relatively scant and diffuse. However, the sensitive tracing methods used in the present study show that, throughout the rat neocortex, large numbers (mean approximately 4500/mm(2)) of thalamocortical neurons converge in layer 1 and that this convergence gives rise to a very high local density of thalamic terminals. Moreover, we show that the layer 1-projecting neurons are present in large numbers in most, but not all, motor, association, limbic, and sensory nuclei of the rodent thalamus. Some layer 1-projecting axons branch to innervate large swaths of the cerebral hemisphere, whereas others arborize within only a single cortical area. Present data imply that realistic modeling of cortical circuitry should factor in a dense axonal canopy carrying highly convergent thalamocortical input to pyramidal cell apical tufts. In addition, they are consistent with the notion that layer 1-projecting axons may be a robust anatomical substrate for extensive "feedback" interactions between cortical areas via the thalamus.

  9. Convergence of high order perturbative expansions in open system quantum dynamics

    Science.gov (United States)

    Xu, Meng; Song, Linze; Song, Kai; Shi, Qiang

    2017-02-01

    We propose a new method to directly calculate high order perturbative expansion terms in open system quantum dynamics. They are first written explicitly in path integral expressions. A set of differential equations are then derived by extending the hierarchical equation of motion (HEOM) approach. As two typical examples for the bosonic and fermionic baths, specific forms of the extended HEOM are obtained for the spin-boson model and the Anderson impurity model. Numerical results are then presented for these two models. General trends of the high order perturbation terms as well as the necessary orders for the perturbative expansions to converge are analyzed.

  10. Internal Consistency and Convergent Validity of the Portuguese Versions of the Global Appraisal of Individual Needs-Initial and Short Screener: Validity of the Portuguese GAIN-I and SS.

    Science.gov (United States)

    Garcia Claro, Heloísa; Ferreira de Oliveira, Márcia Aparecida; de Almeida Lopes Fernandes, Ivan Filipe; Titus, Janet C; Ribeiro Tarifa, Rosana; Fernandes Rojas, Thais; Hayasi Pinho, Paula

    The goal of this article is to present evidence on the internal consistency and convergent validity of the Brazilian Portuguese versions of the Global Appraisal of Individual Needs-"Initial" and "Short Screener" versions. One hundred sixty-eight individuals from an inpatient service and/or a community-based outpatient service located in São Paulo were interviewed using the Brazilian Portuguese versions of the instruments. The internal consistency of the instruments scales was computed, along with evidence for the convergent validity between corresponding subscales of the Initial and Short Screener instruments. Cronbach's alpha values for both instruments' total scale scores were greater than .7. The Short Screener scales showed strong-to-moderate correlations with corresponding subscales of the Initial. The General Individual Severity Scale from the Initial and Total Disorder Screener from the Short Screener have convergent validity with each other (ρ = 0.801). The Brazilian Portuguese instrument scales showed evidence for internal consistency and convergent validity performing similarly to the American English versions.

  11. Convergent validity and sex differences in healthy elderly adults for performance on 3D virtual reality navigation learning and 2D hidden maze tasks.

    Science.gov (United States)

    Tippett, William J; Lee, Jang-Han; Mraz, Richard; Zakzanis, Konstantine K; Snyder, Peter J; Black, Sandra E; Graham, Simon J

    2009-04-01

    This study assessed the convergent validity of a virtual environment (VE) navigation learning task, the Groton Maze Learning Test (GMLT), and selected traditional neuropsychological tests performed in a group of healthy elderly adults (n = 24). The cohort was divided equally between males and females to explore performance variability due to sex differences, which were subsequently characterized and reported as part of the analysis. To facilitate performance comparisons, specific "efficiency" scores were created for both the VE navigation task and the GMLT. Men reached peak performance more rapidly than women during VE navigation and on the GMLT and significantly outperformed women on the first learning trial in the VE. Results suggest reasonable convergent validity across the VE task, GMLT, and selected neuropsychological tests for assessment of spatial memory.

  12. Convergent Evolution towards High Net Carbon Gain Efficiency Contributes to the Shade Tolerance of Palms (Arecaceae).

    Science.gov (United States)

    Ma, Ren-Yi; Zhang, Jiao-Lin; Cavaleri, Molly A; Sterck, Frank; Strijk, Joeri S; Cao, Kun-Fang

    2015-01-01

    Most palm species occur in the shaded lower strata of tropical rain forests, but how their traits relate to shade adaptation is poorly understood. We hypothesized that palms are adapted to the shade of their native habitats by convergent evolution towards high net carbon gain efficiency (CGEn), which is given by the maximum photosynthetic rate to dark respiration rate ratio. Leaf mass per area, maximum photosynthetic rate, dark respiration and N and P concentrations were measured in 80 palm species grown in a common garden, and combined with data of 30 palm species growing in their native habitats. Compared to other species from the global leaf economics data, dicotyledonous broad-leaved trees in tropical rainforest or other monocots in the global leaf economics data, palms possessed consistently higher CGEn, achieved by lowered dark respiration and fairly high foliar P concentration. Combined phylogenetic analyses of evolutionary signal and trait evolution revealed convergent evolution towards high CGEn in palms. We conclude that high CGEn is an evolutionary strategy that enables palms to better adapt to shady environments than coexisting dicot tree species, and may convey advantages in competing with them in the tropical forest understory. These findings provide important insights for understanding the evolution and ecology of palms, and for understanding plant shade adaptations of lower rainforest strata. Moreover, given the dominant role of palms in tropical forests, these findings are important for modelling carbon and nutrient cycling in tropical forest ecosystems.

  13. Convergent Evolution towards High Net Carbon Gain Efficiency Contributes to the Shade Tolerance of Palms (Arecaceae.

    Directory of Open Access Journals (Sweden)

    Ren-Yi Ma

    Full Text Available Most palm species occur in the shaded lower strata of tropical rain forests, but how their traits relate to shade adaptation is poorly understood. We hypothesized that palms are adapted to the shade of their native habitats by convergent evolution towards high net carbon gain efficiency (CGEn, which is given by the maximum photosynthetic rate to dark respiration rate ratio. Leaf mass per area, maximum photosynthetic rate, dark respiration and N and P concentrations were measured in 80 palm species grown in a common garden, and combined with data of 30 palm species growing in their native habitats. Compared to other species from the global leaf economics data, dicotyledonous broad-leaved trees in tropical rainforest or other monocots in the global leaf economics data, palms possessed consistently higher CGEn, achieved by lowered dark respiration and fairly high foliar P concentration. Combined phylogenetic analyses of evolutionary signal and trait evolution revealed convergent evolution towards high CGEn in palms. We conclude that high CGEn is an evolutionary strategy that enables palms to better adapt to shady environments than coexisting dicot tree species, and may convey advantages in competing with them in the tropical forest understory. These findings provide important insights for understanding the evolution and ecology of palms, and for understanding plant shade adaptations of lower rainforest strata. Moreover, given the dominant role of palms in tropical forests, these findings are important for modelling carbon and nutrient cycling in tropical forest ecosystems.

  14. A focusable, convergent fast-electron beam from ultra-high-intensity laser-solid interactions

    CERN Document Server

    Scott, R H H

    2015-01-01

    A novel scheme for the creation of a convergent, or focussing, fast-electron beam generated from ultra-high-intensity laser-solid interactions is described. Self-consistent particle-in-cell simulations are used to demonstrate the efficacy of this scheme in two dimensions. It is shown that a beam of fast-electrons of energy 500 keV - 3 MeV propagates within a solid-density plasma, focussing at depth. The depth of focus of the fast-electron beam is controlled via the target dimensions and focussing optics.

  15. Convergence of valence bands for high thermoelectric performance for p-type InN

    Science.gov (United States)

    Li, Hai-Zhu; Li, Ruo-Ping; Liu, Jun-Hui; Huang, Ming-Ju

    2015-12-01

    Band engineering to converge the bands to achieve high valley degeneracy is one of effective approaches for designing ideal thermoelectric materials. Convergence of many valleys in the valence band may lead to a high Seebeck coefficient, and induce promising thermoelectric performance of p-type InN. In the current work, we have systematically investigated the electronic structure and thermoelectric performance of wurtzite InN by using the density functional theory combined with semiclassical Boltzmann transport theory. Form the results, it can be found that intrinsic InN has a large Seebeck coefficient (254 μV/K) and the largest value of ZeT is 0.77. The transport properties of p-type InN are better than that of n-type one at the optimum carrier concentration, which mainly due to the large Seebeck coefficient for p-type InN, although the electrical conductivity of n-type InN is larger than that of p-type one. We found that the larger Seebeck coefficient for p-type InN may originate from the large valley degeneracy in the valence band. Moreover, the low minimum lattice thermal conductivity for InN is one key factor to become a good thermoelectric material. Therefore, p-type InN could be a potential material for further applications in the thermoelectric area.

  16. Experimental validation of prototype high voltage bushing

    Science.gov (United States)

    Shah, Sejal; Tyagi, H.; Sharma, D.; Parmar, D.; M. N., Vishnudev; Joshi, K.; Patel, K.; Yadav, A.; Patel, R.; Bandyopadhyay, M.; Rotti, C.; Chakraborty, A.

    2017-08-01

    Prototype High voltage bushing (PHVB) is a scaled down configuration of DNB High Voltage Bushing (HVB) of ITER. It is designed for operation at 50 kV DC to ensure operational performance and thereby confirming the design configuration of DNB HVB. Two concentric insulators viz. Ceramic and Fiber reinforced polymer (FRP) rings are used as double layered vacuum boundary for 50 kV isolation between grounded and high voltage flanges. Stress shields are designed for smooth electric field distribution. During ceramic to Kovar brazing, spilling cannot be controlled which may lead to high localized electrostatic stress. To understand spilling phenomenon and precise stress calculation, quantitative analysis was performed using Scanning Electron Microscopy (SEM) of brazed sample and similar configuration modeled while performing the Finite Element (FE) analysis. FE analysis of PHVB is performed to find out electrical stresses on different areas of PHVB and are maintained similar to DNB HV Bushing. With this configuration, the experiment is performed considering ITER like vacuum and electrical parameters. Initial HV test is performed by temporary vacuum sealing arrangements using gaskets/O-rings at both ends in order to achieve desired vacuum and keep the system maintainable. During validation test, 50 kV voltage withstand is performed for one hour. Voltage withstand test for 60 kV DC (20% higher rated voltage) have also been performed without any breakdown. Successful operation of PHVB confirms the design of DNB HV Bushing. In this paper, configuration of PHVB with experimental validation data is presented.

  17. Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level.

    Directory of Open Access Journals (Sweden)

    Chandrasekhar Natarajan

    2015-12-01

    Full Text Available A fundamental question in evolutionary genetics concerns the extent to which adaptive phenotypic convergence is attributable to convergent or parallel changes at the molecular sequence level. Here we report a comparative analysis of hemoglobin (Hb function in eight phylogenetically replicated pairs of high- and low-altitude waterfowl taxa to test for convergence in the oxygenation properties of Hb, and to assess the extent to which convergence in biochemical phenotype is attributable to repeated amino acid replacements. Functional experiments on native Hb variants and protein engineering experiments based on site-directed mutagenesis revealed the phenotypic effects of specific amino acid replacements that were responsible for convergent increases in Hb-O2 affinity in multiple high-altitude taxa. In six of the eight taxon pairs, high-altitude taxa evolved derived increases in Hb-O2 affinity that were caused by a combination of unique replacements, parallel replacements (involving identical-by-state variants with independent mutational origins in different lineages, and collateral replacements (involving shared, identical-by-descent variants derived via introgressive hybridization. In genome scans of nucleotide differentiation involving high- and low-altitude populations of three separate species, function-altering amino acid polymorphisms in the globin genes emerged as highly significant outliers, providing independent evidence for adaptive divergence in Hb function. The experimental results demonstrate that convergent changes in protein function can occur through multiple historical paths, and can involve multiple possible mutations. Most cases of convergence in Hb function did not involve parallel substitutions and most parallel substitutions did not affect Hb-O2 affinity, indicating that the repeatability of phenotypic evolution does not require parallelism at the molecular level.

  18. Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level.

    Science.gov (United States)

    Natarajan, Chandrasekhar; Projecto-Garcia, Joana; Moriyama, Hideaki; Weber, Roy E; Muñoz-Fuentes, Violeta; Green, Andy J; Kopuchian, Cecilia; Tubaro, Pablo L; Alza, Luis; Bulgarella, Mariana; Smith, Matthew M; Wilson, Robert E; Fago, Angela; McCracken, Kevin G; Storz, Jay F

    2015-12-01

    A fundamental question in evolutionary genetics concerns the extent to which adaptive phenotypic convergence is attributable to convergent or parallel changes at the molecular sequence level. Here we report a comparative analysis of hemoglobin (Hb) function in eight phylogenetically replicated pairs of high- and low-altitude waterfowl taxa to test for convergence in the oxygenation properties of Hb, and to assess the extent to which convergence in biochemical phenotype is attributable to repeated amino acid replacements. Functional experiments on native Hb variants and protein engineering experiments based on site-directed mutagenesis revealed the phenotypic effects of specific amino acid replacements that were responsible for convergent increases in Hb-O2 affinity in multiple high-altitude taxa. In six of the eight taxon pairs, high-altitude taxa evolved derived increases in Hb-O2 affinity that were caused by a combination of unique replacements, parallel replacements (involving identical-by-state variants with independent mutational origins in different lineages), and collateral replacements (involving shared, identical-by-descent variants derived via introgressive hybridization). In genome scans of nucleotide differentiation involving high- and low-altitude populations of three separate species, function-altering amino acid polymorphisms in the globin genes emerged as highly significant outliers, providing independent evidence for adaptive divergence in Hb function. The experimental results demonstrate that convergent changes in protein function can occur through multiple historical paths, and can involve multiple possible mutations. Most cases of convergence in Hb function did not involve parallel substitutions and most parallel substitutions did not affect Hb-O2 affinity, indicating that the repeatability of phenotypic evolution does not require parallelism at the molecular level.

  19. High dynamic GPS receiver validation demonstration

    Science.gov (United States)

    Hurd, W. J.; Statman, J. I.; Vilnrotter, V. A.

    1985-01-01

    The Validation Demonstration establishes that the high dynamic Global Positioning System (GPS) receiver concept developed at JPL meets the dynamic tracking requirements for range instrumentation of missiles and drones. It was demonstrated that the receiver can track the pseudorange and pseudorange rate of vehicles with acceleration in excess of 100 g and jerk in excess of 100 g/s, dynamics ten times more severe than specified for conventional High Dynamic GPS receivers. These results and analytic extensions to a complete system configuration establish that all range instrumentation requirements can be met. The receiver can be implemented in the 100 cu in volume required by all missiles and drones, and is ideally suited for transdigitizer or translator applications.

  20. Convergent validity of the Timed Up and Go Test and Ten-metre Timed Walk Test in pregnant women with pelvic girdle pain.

    Science.gov (United States)

    Evensen, Natalie Michelle; Kvåle, Alice; Brækken, Ingeborg Hoff

    2016-02-01

    Pregnant women with pelvic girdle pain (PGP) often experience functional difficulties, in particular walking difficulties. Currently, however, there is a lack of validated performance-orientated outcome measures available for use in this population. The Timed Up and Go (TUG) test and Ten-metre Timed Walk Test (10 mTWT) are two short-distance walking tests that have demonstrated reliability in pregnant women with PGP, but as yet have no established validity. The aim of the present study was to evaluate the convergent validity of the TUG and 10 mTWT by comparing performances on these two walking tests with scores achieved on the Active Straight Leg Raise (ASLR) test and the Pelvic Girdle Questionnaire (PGQ). Eighteen pregnant women with PGP aged 31.4 years (SD = 2.7) and 28.9 weeks pregnant (SD = 7.3) were included. Spearman rank correlation coefficient (rs) was used to determine convergent validity. Strong correlations were found between the TUG and ASLR (rs = 0.73, p = 0.001), and the 10 mTWT and ASLR (rs = -0.65, p = 0.003). Relationships between the TUG and PGQ were moderate (rs = 0.41 to 0.52) and between the 10 mTWT and PGQ low to moderate (rs = -0.25 to -0.56). The strong relationships between the walking tests and the ASLR may suggest these tests all assess the same construct. The weaker relationships found between the walking tests and the PGQ may be related to the self-report and multiple functional activities nature of the questionnaire. This study found both the TUG and 10 mTWT to be valid weight-bearing physical performance measures, although more research is warranted due to the small study sample.

  1. The Short Version of the Activities-Specific Balance Confidence Scale for Older Adults with Diabetes-Convergent, Discriminant and Concurrent Validity: A Pilot Study.

    Science.gov (United States)

    Hewston, Patricia; Deshpande, Nandini

    2017-06-01

    The short version of the Activities-Specific Balance Confidence Scale (ABC-6) is advantageous in busy clinical or research settings because it can be administered in less time than the original 16-item Activities-Specific Balance Confidence Scale (ABC-16). This pilot study examined the convergent, discriminant and concurrent validity of the ABC-6 in older adults with diabetes mellitus with and without diagnosed diabetic peripheral neuropathy (DPN). Thirty older adults (aged ≥65) were age- and sex-matched in 3 groups: 10 with diabetes (DM group), 10 with diagnosed DPN (DPN group) and 10 without diabetes (no-DM group). Balance confidence was quantified by the ABC-16, which includes the ABC-6. Potential correlates were evaluated in physical and psychological domains. The ABC-6 and ABC-16 balance confidence scores were strongly correlated (r=0.969; pconfidence between the no-DM and the DM groups (p0.05). The ABC-6 was moderately, but significantly, correlated with physical activity level (r=0.528; p=0.017), mobility (r=-0.520; p=0.027), balance (r=0.633; p=0.003), and depressive symptoms (r=-0.515; p=0.020) in the DM study groups (concurrent validity). The ABC-6 and ABC-16 had excellent convergent validity, and both ABC scales had similar concurrent validity. However, the ABC-6 was more sensitive in detecting subtle differences in balance confidence in older adults with diabetes without diagnosed DPN than the ABC-16. Overall, this pilot study provided evidence of the validity of the ABC-6 in older adults with diabetes. Further exploration involving a larger sample size is recommended to confirm these findings. Copyright © 2017 Diabetes Canada. Published by Elsevier Inc. All rights reserved.

  2. Convergent validity of the Integrated Visual and Auditory Continuous Performance Test (IVA+Plus): associations with working memory, processing speed, and behavioral ratings.

    Science.gov (United States)

    Arble, Eamonn; Kuentzel, Jeffrey; Barnett, Douglas

    2014-05-01

    Though the Integrated Visual and Auditory Continuous Performance Test (IVA + Plus) is commonly used by researchers and clinicians, few investigations have assessed its convergent and discriminant validity, especially with regard to its use with children. The present study details correlates of the IVA + Plus using measures of cognitive ability and ratings of child behavior (parent and teacher), drawing upon a sample of 90 psychoeducational evaluations. Scores from the IVA + Plus correlated significantly with the Working Memory and Processing Speed Indexes from the Fourth Edition of the Wechsler Intelligence Scales for Children (WISC-IV), though fewer and weaker significant correlations were seen with behavior ratings scales, and significant associations also occurred with WISC-IV Verbal Comprehension and Perceptual Reasoning. The overall pattern of relations is supportive of the validity of the IVA + Plus; however, general cognitive ability was associated with better performance on most of the primary scores of the IVA + Plus, suggesting that interpretation should take intelligence into account.

  3. The French Version of the Screen for Child Anxiety Related Emotional Disorders-Revised (Scared-R: Factor Structure, Convergent and Divergent Validity in a Sample of Teenagers

    Directory of Open Access Journals (Sweden)

    Martine Bouvard

    2013-06-01

    Full Text Available The principal objective of this study is to provide data on the French version of the SCARED-R. This article investigates the factor structure of the French version of the Screen for Child Anxiety Related Emotional Disorders-Revised (SCARED-R and its convergent and divergent validity. 704 normal adolescents aged 10 to 19 years completed the questionnaires in their classrooms. A sub-sample of 595 adolescents also completed an anxiety questionnaire (the French version of the Fear Survey Schedule for Children-Revised, FSSC-R and a depression questionnaire (the French version of the Center for Epidemiological Studies Depression Scale, CES-D. Confirmatory factor analysis of the SCARED-R suggested reasonable fit for the 9-factor model. The comparison of the convergent and divergent validity revealed that the SCARED-R total score and five SCARED-R subscales (SAD, Social Phobia and the three Specific Phobias correlated more strongly with anxiety than depression. The other SCARED-R subscales (GAD, Panic Disorder, OCD and PTSD are positively related to levels of anxiety and depression. Altogether, the French version of the SCARED-R showed reasonable psychometric properties.

  4. Convergent validity of the ACC/AHA pooled cohort equations in associating with health-related quality of life among adults in the United States

    Science.gov (United States)

    Nooe, Allison; Edwards, Meghan K.; Addoh, Ovuokerie; Loprinzi, Paul D.

    2017-01-01

    Background: The potential convergent validity of the pooled cohort risk (PCR) equations in predicting health-related quality of life (HRQOL) has yet to be evaluated, which was this study’s purpose. Methods: Data from the 2001-2011 National Health and Nutrition Examination Survey (NHANES) were used (N = 8978 adults, 40-79 years, free of cardiovascular disease at baseline). Calculation of an individual’s 10-year risk of a first atherosclerotic cardiovascular disease (ASCVD) event was determined via the PCR equation. The Centers for Disease Control and Prevention (CDC) HRQOL measure was assessed utilizing 4 questions regarding participants’ perceived mental and physical health status from the past 30 days. Results: When adjusting for moderate-to-vigorous physical activity (MVPA), obesity, age, gender and race-ethnicity, an ASCVD score of >20% (vs. HRQOL score. A higher HRQOL score indicates a poorer patient perception of their mental and physical health. Conclusion: The observed association between PCR-determined ASCVD-risk scores and HRQOL provides evidence for the convergent validity of the PCR algorithms, indicating that individuals with a higher risk for a first time ASCVD-event may also have an overall worse HRQOL. As such, employing ASCVD risk reduction efforts may be an important strategy in improving an individual’s HRQOL. PMID:28058241

  5. Convergent validity of the ACC/AHA pooled cohort equations in associating with health-related quality of life among adults in the United States.

    Science.gov (United States)

    Nooe, Allison; Edwards, Meghan K; Addoh, Ovuokerie; Loprinzi, Paul D

    2017-01-01

    Background: The potential convergent validity of the pooled cohort risk (PCR) equations in predicting health-related quality of life (HRQOL) has yet to be evaluated, which was this study's purpose. Methods: Data from the 2001-2011 National Health and Nutrition Examination Survey (NHANES) were used (N = 8978 adults, 40-79 years, free of cardiovascular disease at baseline). Calculation of an individual's 10-year risk of a first atherosclerotic cardiovascular disease (ASCVD) event was determined via the PCR equation. The Centers for Disease Control and Prevention (CDC) HRQOL measure was assessed utilizing 4 questions regarding participants' perceived mental and physical health status from the past 30 days. Results: When adjusting for moderate-to-vigorous physical activity (MVPA), obesity, age, gender and race-ethnicity, an ASCVD score of >20% (vs. <20%) was associated with a 0.53-unit (95% CI: 0.34-0.71) higher HRQOL score. A higher HRQOL score indicates a poorer patient perception of their mental and physical health. Conclusion: The observed association between PCR-determined ASCVD-risk scores and HRQOL provides evidence for the convergent validity of the PCR algorithms, indicating that individuals with a higher risk for a first time ASCVD-event may also have an overall worse HRQOL. As such, employing ASCVD risk reduction efforts may be an important strategy in improving an individual's HRQOL.

  6. High-resolution velocimetry in energetic tidal currents using a convergent-beam acoustic Doppler profiler

    Science.gov (United States)

    Sellar, Brian; Harding, Samuel; Richmond, Marshall

    2015-08-01

    An array of single-beam acoustic Doppler profilers has been developed for the high resolution measurement of three-dimensional tidal flow velocities and subsequently tested in an energetic tidal site. This configuration has been developed to increase spatial resolution of velocity measurements in comparison to conventional acoustic Doppler profilers (ADPs) which characteristically use divergent acoustic beams emanating from a single instrument. This is achieved using geometrically convergent acoustic beams creating a sample volume at the focal point of 0.03 m3. Away from the focal point, the array is also able to simultaneously reconstruct three-dimensional velocity components in a profile throughout the water column, and is referred to herein as a convergent-beam acoustic Doppler profiler (C-ADP). Mid-depth profiling is achieved through integration of the sensor platform with the operational commercial-scale Alstom 1 MW DeepGen-IV Tidal Turbine deployed at the European Marine Energy Center, Orkney Isles, UK. This proof-of-concept paper outlines the C-ADP system configuration and comparison to measurements provided by co-installed reference instrumentation. Comparison of C-ADP to standard divergent ADP (D-ADP) velocity measurements reveals a mean difference of 8 mm s-1, standard deviation of 18 mm s-1, and an order of magnitude reduction in realisable length scale. C-ADP focal point measurements compared to a proximal single-beam reference show peak cross-correlation coefficient of 0.96 over 4.0 s averaging period and a 47% reduction in Doppler noise. The dual functionality of the C-ADP as a profiling instrument with a high resolution focal point make this configuration a unique and valuable advancement in underwater velocimetry enabling improved quantification of flow turbulence. Since waves are simultaneously measured via profiled velocities, pressure measurements and surface detection, it is expected that derivatives of this system will be a powerful tool in

  7. Suppression associated with esotropia with convergence excess (high AC/A ratio).

    Science.gov (United States)

    Pratt-Johnson, J A

    1984-08-15

    With binocular perimetry suppression was found for near vision in patients with esotropia with convergence excess, whereas fusion was present for distance. If a bitenuporal stimulation was obtained by means of base-out prisms, diplopia was elicited instead.

  8. Convergence Insufficiency

    Science.gov (United States)

    ... from convergence insufficiency? Symptoms of convergence insufficiency include diplopia (double vision) and headaches when reading. Many patients ... another time or simply watched for symptoms of diplopia or headaches with near work. A patient who ...

  9. Response character styles in adolescents: a replication of convergent validity between the MMPI-A and the Rorschach.

    Science.gov (United States)

    Stokes, John M; Pogge, David L; Zaccario, Michele

    2013-01-01

    This study explored the extent to which similar or discordant response character styles (RCS) affected convergence between MMPI-A and Rorschach findings in a sample of 673 adolescents from a psychiatric inpatient setting. Meyer's (Meyer, 1997; Meyer, Riethmiller, Brooks, Benoit, & Handler, 2000) findings for adult samples were generally replicated in that adolescents showing similar RCS across both measures showed moderate to strong relationships between Rorschach and MMPI-A indicants of affective distress, psychosis, and interpersonal wariness, whereas those showing discordant RCS demonstrated negligible or negative correlations between these indicants. This pattern was evident for conceptually similar, but not conceptually unrelated variable pairs. Similarity and discordance of RCS was also found to have an impact on relationships with external criterion variables, including therapist ratings and discharge diagnoses. Moderated regression analysis supports the hypothesis that RCS moderates the strength of the relationship between Rorschach and MMPI-A. Implications for practice and future research are discussed.

  10. Low Convergence path to Fusion I: Ignition physics and high margin design

    Science.gov (United States)

    Molvig, Kim; Schmitt, M. J.; McCall, G. H.; Betti, R.; Foula, D. H.; Campbell, E. M.

    2016-10-01

    A new class of inertial fusion capsules is presented that combines multi-shell targets with laser direct drive at low intensity (280 TW/cm2) to achieve robust ignition. These Revolver targets consist of three concentric metal shells, enclosing a volume of 10s of µg of liquid deuterium-tritium fuel. The inner shell pusher, nominally of gold, is compressed to over 2000 g/cc, effectively trapping the radiation and enabling ignition at low temperature (2.5 keV) and relatively low implosion velocity (20 cm/micro-sec) at a fuel convergence of 9. Ignition is designed to occur well ``upstream'' from stagnation, with implosion velocity at 90% of maximum, so that any deceleration phase mix will occur only after ignition. Mix, in all its non-predictable manifestations, will effect net yield in a Revolver target - but not the achievement of ignition and robust burn. Simplicity of the physics is the dominant principle. There is no high gain requirement. These basic physics elements can be combined into a simple analytic model that generates a complete target design specification given the fuel mass and the kinetic energy needed in the middle (drive) shell (of order 80 kJ). This research supported by the US DOE/NNSA, performed in part at LANL, operated by LANS LLC under contract DE-AC52-06NA25396.

  11. On the well-posedness of multivariate spectrum approximation and convergence of high-resolution spectral estimators

    CERN Document Server

    Ramponi, Federico; Pavon, Michele

    2009-01-01

    In this paper, we establish the well-posedness of the generalized moment problems recently studied by Byrnes-Georgiou-Lindquist and coworkers, and by Ferrante-Pavon-Ramponi. We then apply these continuity results to prove almost sure convergence of a sequence of high-resolution spectral estimators indexed by the sample size.

  12. Convergent Validity of the Autism Spectrum Disorders-Diagnostic Adult (ASD-DA) with the Pervasive Developmental Disorder/Autism Subscale of the Diagnostic Assessment for the Severely Handicapped-II (DASH-II)

    Science.gov (United States)

    Belva, Brian C.; Matson, Johnny L.; Hattier, Megan A.; Kozlowski, Allison M.; Bamburg, Jay W.

    2012-01-01

    The "Autism Spectrum Disorders-Diagnosis for Adults" ("ASD-DA") is a standardized assessment used to measure autistic symptomatology in adults with intellectual disabilities (ID). In order to further establish the validity of this measure, convergent validity of the "ASD-DA" was established by comparing "ASD-DA" total and subscales scores with the…

  13. Convergent Validity with the BERS-2 Teacher Rating Scale and the Achenbach Teacher's Report Form: A Replication and Extension

    Science.gov (United States)

    Benner, Gregory J.; Beaudoin, Kathleen; Mooney, Paul; Uhing, Brad M.; Pierce, Corey D.

    2008-01-01

    In the present study, we sought to extend instrument validation research for a strength-based emotional and behavior rating scale, the "Teacher Rating Scale of the Behavior and Emotional Rating Scale-Second Edition" (BERS-2; Epstein, M. H. (2004). "Behavioral and emotional rating scale" (2nd ed.). Austin, TX: PRO-ED) through…

  14. Convergent Validity with the BERS-2 Teacher Rating Scale and the Achenbach Teacher's Report Form: A Replication and Extension

    Science.gov (United States)

    Benner, Gregory J.; Beaudoin, Kathleen; Mooney, Paul; Uhing, Brad M.; Pierce, Corey D.

    2008-01-01

    In the present study, we sought to extend instrument validation research for a strength-based emotional and behavior rating scale, the "Teacher Rating Scale of the Behavior and Emotional Rating Scale-Second Edition" (BERS-2; Epstein, M. H. (2004). "Behavioral and emotional rating scale" (2nd ed.). Austin, TX: PRO-ED) through…

  15. A factor confirmation and convergent validity of the “areas of worklife scale” (AWS) to Spanish translation

    Science.gov (United States)

    2013-01-01

    Background Perceived incongruity between the individual and the job on work-life areas such as workload, control, reward, fairness, community and values have implications for the dimensions of burnout syndrome. The “Areas of Work-life Scale” (AWS) is a practical instrument to measure employees´ perceptions of their work environments. AIMS: Validate a Spanish translation of the AWS, and it relationship with Masclach Burnout Inventory dimensions. Methods The study was conducted in three medium-sized hospitals and seven rural and urban Primary Care centres (N = 871) in Spain. The “Maslach Burnout Inventory General Survey” (MBI-GS) and AWS were applied. We developed a complete psychometric analysis of its reliability, and validity. Results Data on the reliability supported a good internal consistency (Cronbach α between .71, and .85). Construct validity was confirmed by a six factor model of the AWS as a good measure of work environments (χ2(352) = 806.21, p < 0.001; χ2/df = 2.29; CFI = 0.935, RMSEA = 0.039); concurrent validity was analysed for its relationship with other measures (opposing dimensions to burnout, and MBI), and each correlation between dimensions and sub-dimensions were statistically significant; as well, predictive validity, by a series of Multiple Regression Analysis examined the resulting patterns of the Confirmatory Factor Analysis (CFA) confirms the relationship between the work-life areas and burnout dimensions. Conclusions Leiter and Maslach’s AWS has been an important instrument in exploring several work-life factors that contribute to burnout. This scale can now be used to assess the quality of work-life in order to design and assess the need for intervention programs in Spanish-speaking countries. PMID:23596987

  16. Towards parsimony in habit measurement: Testing the convergent and predictive validity of an automaticity subscale of the Self-Report Habit Index

    Directory of Open Access Journals (Sweden)

    Gardner Benjamin

    2012-08-01

    Full Text Available Abstract Background The twelve-item Self-Report Habit Index (SRHI is the most popular measure of energy-balance related habits. This measure characterises habit by automatic activation, behavioural frequency, and relevance to self-identity. Previous empirical research suggests that the SRHI may be abbreviated with no losses in reliability or predictive utility. Drawing on recent theorising suggesting that automaticity is the ‘active ingredient’ of habit-behaviour relationships, we tested whether an automaticity-specific SRHI subscale could capture habit-based behaviour patterns in self-report data. Methods A content validity task was undertaken to identify a subset of automaticity indicators within the SRHI. The reliability, convergent validity and predictive validity of the automaticity item subset was subsequently tested in secondary analyses of all previous SRHI applications, identified via systematic review, and in primary analyses of four raw datasets relating to energy‐balance relevant behaviours (inactive travel, active travel, snacking, and alcohol consumption. Results A four-item automaticity subscale (the ‘Self-Report Behavioural Automaticity Index’; ‘SRBAI’ was found to be reliable and sensitive to two hypothesised effects of habit on behaviour: a habit-behaviour correlation, and a moderating effect of habit on the intention-behaviour relationship. Conclusion The SRBAI offers a parsimonious measure that adequately captures habitual behaviour patterns. The SRBAI may be of particular utility in predicting future behaviour and in studies tracking habit formation or disruption.

  17. Treatment of Partly Accommodative Esotropia With a High Accommodative Convergence-Accommodation Ratio

    NARCIS (Netherlands)

    H.J. Simonsz (Huib)

    1988-01-01

    textabstractIn the June 1987 issue of the Archives, the results were published of a study by Kushner et al1 on the treatment of accommodative convergence excess, with bilateral medial rectus recessions or recessions with 14-mm posterior fixation sutures. Posterior fixation surgery was considered an

  18. Convergence of eigenvalues for a highly non-self-adjoint differential operator

    CERN Document Server

    Davies, E B

    2008-01-01

    In this paper we study a family of operators dependent on a small parameter $\\epsilon > 0$, which arise in a problem in fluid mechanics. We show that the spectra of these operators converge to N as $\\epsilon \\to 0$, even though, for fixed $\\epsilon > 0$, the eigenvalue asymptotics are quadratic.

  19. Convergence Patterns in Latin America

    DEFF Research Database (Denmark)

    Quiroga, Paola Andrea Barrientos

    Literature on convergence among Latin American countries is still scarce compared to other regions. Moreover, almost none of the research connects convergence to the economic history of Latin America and the usual finding is one speed of convergence. In this paper I analyze 32 countries and 108...... years, more observations than any other study. This long span of data allows me to use economic history to explain, analyze, validate, and understand the results of convergence patterns in the region. I find more than one speed of convergence (clubs) related to the known historical background, country...

  20. The Five-Factor Narcissism Inventory (FFNI): a test of the convergent, discriminant, and incremental validity of FFNI scores in clinical and community samples.

    Science.gov (United States)

    Miller, Joshua D; Few, Lauren R; Wilson, Lauren; Gentile, Brittany; Widiger, Thomas A; Mackillop, James; Keith Campbell, W

    2013-09-01

    The five-factor narcissism inventory (FFNI) is a new self-report measure that was developed to assess traits associated with narcissistic personality disorder (NPD), as well as grandiose and vulnerable narcissism from a five-factor model (FFM) perspective. In the current study, the FFNI was examined in relation to Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; DSM-IV; American Psychiatric Association, 2000) NPD, DSM-5 (http://www.dsm5.org) NPD traits, grandiose narcissism, and vulnerable narcissism in both community (N = 287) and clinical samples (N = 98). Across the samples, the FFNI scales manifested good convergent and discriminant validity such that FFNI scales derived from FFM neuroticism were primarily related to vulnerable narcissism scores, scales derived from FFM extraversion were primarily related to grandiose scores, and FFNI scales derived from FFM agreeableness were related to both narcissism dimensions, as well as the DSM-IV and DSM-5 NPD scores. The FFNI grandiose and vulnerable narcissism composites also demonstrated incremental validity in the statistical prediction of these scores, above and beyond existing measures of DSM NPD, grandiose narcissism, and vulnerable narcissism, respectively. The FFNI is a promising measure that provides a comprehensive assessment of narcissistic pathology while maintaining ties to the significant general personality literature on the FFM.

  1. Convergent Validation of the Kohlman Evaluation of Living Skills (KELS) as a Screening Tool of Older Adults’ Capacity to Live Safely and Independently in the Community

    Science.gov (United States)

    Burnett, Jason; Dyer, Carmel B.; Naik, Aanand D.

    2010-01-01

    Objective Convergent validation of the Kohlman Evaluation of Living Skills (KELS) to screen older adults’ capacity for safe and independent living. Design Cross-sectional study correlating KELS with components of a Comprehensive Geriatric Assessment. Setting Participants’ homes Participants 200 community-dwelling older adults aged ≥65 including 100 referred by adult protective services (APS) and 100 ambulatory patients matched on age, race, gender, and socio-economic status. Interventions In-home comprehensive assessment Main Outcome Measures Kohlman Evaluation of Living Skills (KELS), Geriatric Depression Scale (GDS), Physical Performance Test (mPPT), Mini-mental state examination (MMSE), Knee Extensor Break Test, Executive test (EXIT25), CLOX 1 & 2, and an 8-foot walk test. Results Older adults with abnormal KELS scores performed significantly worse on all tests except for the Knee Extensor Break Test. Accordingly, among the entire group, the KELS correlated with measures of executive function (EXIT25, r = .705, p older adults’ ability to live safely and independently in the community. KELS may be a valid and pragmatic alternative to screen for the capacity to live safely and independently among older adults. PMID:19887222

  2. Assessing clinical reasoning skills in scenarios of uncertainty: convergent validity for a Script Concordance Test in an emergency medicine clerkship and residency.

    Science.gov (United States)

    Humbert, Aloysius J; Besinger, Bart; Miech, Edward J

    2011-06-01

    The Script Concordance Test (SCT) is a new method of assessing clinical reasoning in the face of uncertainty. An SCT item consists of a short clinical vignette followed by an additional piece of information and asks how this new information affects the learner's decision regarding a possible diagnosis, investigational study, or therapy. Scoring is based on the item responses of a panel of experts in the field. This study attempts to provide additional validity evidence in the realm of emergency medicine (EM). This observational study examined the performance of medical students, EM residents, and expert emergency physicians (EPs) on an SCT in the area of general EM (SCT-EM) at one of the largest medical schools in the United States. The 59-item SCT-EM was developed for a fourth-year required clerkship in EM. The results on the SCT-EM were compared between different levels of clinical experience. Results were also compared to performance on other measures to evaluate convergent validity. The SCT-EM was given to 314 fourth-year medical students (MS4), 40 EM residents, and 13 EPs during the study period. Mean differences between the three different groups of test takers was statistically significant (p reasoning skills in the face of uncertainty. Future research will compare performance on the SCT to other measures of clinical reasoning abilities. © 2011 by the Society for Academic Emergency Medicine.

  3. Combining Two Methods of Sequence Definition in a Convergent Approach: Scalable Synthesis of Highly Defined and Multifunctionalized Macromolecules.

    Science.gov (United States)

    Solleder, Susanne C; Martens, Steven; Espeel, Pieter; Du Prez, Filip; Meier, Michael A R

    2017-08-23

    The straightforward convergent synthesis of sequence-defined and multifunctionalized macromolecules is described herein. The first combination of two efficient approaches for the synthesis of sequence-defined macromolecules is reported: thiolactone chemistry and the Passerini three-component reaction (P-3CR). The thiolactone moiety was used as protecting group for the thiol, allowing the synthesis of a library of sequence-defined α,ω-functionalized building blocks. These building blocks were subsequently efficiently coupled to oligomers with carboxylic acid functionalities in a P-3CR. Thus, larger oligomers with molecular weights of up to 4629.73 g mol(-1) were obtained in gram quantities in a convergent approach along with the introduction of independently selectable side chains (up to 15), thus clearly demonstrating the high versatility and the efficiency of the reported approach. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Convergent and discriminant validity of psychiatric symptoms reported in The Norwegian Mother and Child Cohort Study at age 3 years with independent clinical assessment in the Longitudinal ADHD Cohort Study

    Directory of Open Access Journals (Sweden)

    Guido Biele

    2014-12-01

    Full Text Available Epidemiological studies often use parent questionnaires to assess children's development and mental health. To date, few studies have investigated the validity of parent questionnaires with standardized clinical assessments as criterion. The current study examines discriminant and convergent validity of parent questionnaires for symptoms of Attention Deficit Hyperactivity Disorder (ADHD, Oppositional Defiance Disorder (ODD, and Conduct Disorder (CD as well as symptoms of Separation Anxiety employed in the Norwegian Mother and Child Cohort Study by using structured clinical interviews performed 5 months later in the Longitudinal ADHD Cohort Study as a criterion. The comparison of confirmatory factor analysis models and examination of factor correlations indicate convergent and discriminant validity of MoBa parent questionnaires for preschool children, especially for the assessment of ADHD and ODD/CD. Future research should attempt to further improve parent questionnaires, examine their validity in representative samples, and explicitly test their utility for screening.

  5. Validez Convergente de la Version Espanola Preliminar del Child Abuse Potential Inventory: Depresion y Aduste Marital (Convergent Validity of the Preliminary Spanish Version of the Child Abuse Potential Inventory: Depression and Marital Adjustment).

    Science.gov (United States)

    Arruabarrena, M. Ignacia; de Paul, Joaquin

    1992-01-01

    "Convergent validity" of preliminary Spanish version of Child Abuse Potential (CAP) Inventory was studied. CAP uses ecological-systemic model of child maltreatment to evaluate individual, family, and social factors facilitating physical child abuse. Depression and marital adjustment were measured in three groups of mothers. Results found…

  6. Validez Convergente de la Version Espanola Preliminar del Child Abuse Potential Inventory: Depresion y Aduste Marital (Convergent Validity of the Preliminary Spanish Version of the Child Abuse Potential Inventory: Depression and Marital Adjustment).

    Science.gov (United States)

    Arruabarrena, M. Ignacia; de Paul, Joaquin

    1992-01-01

    "Convergent validity" of preliminary Spanish version of Child Abuse Potential (CAP) Inventory was studied. CAP uses ecological-systemic model of child maltreatment to evaluate individual, family, and social factors facilitating physical child abuse. Depression and marital adjustment were measured in three groups of mothers. Results found…

  7. Magnetized Converging Flows toward the Hot Core in the Intermediate/High-mass Star-forming Region NGC 6334 V

    Science.gov (United States)

    Juárez, Carmen; Girart, Josep M.; Zamora-Avilés, Manuel; Tang, Ya-Wen; Koch, Patrick M.; Liu, Hauyu Baobab; Palau, Aina; Ballesteros-Paredes, Javier; Zhang, Qizhou; Qiu, Keping

    2017-07-01

    We present Submillimeter Array (SMA) observations at 345 GHz toward the intermediate/high-mass cluster-forming region NGC 6334 V. From the dust emission we spatially resolve three dense condensations, the brightest one presenting the typical chemistry of a hot core. The magnetic field (derived from the dust polarized emission) shows a bimodal converging pattern toward the hot core. The molecular emission traces two filamentary structures at two different velocities, separated by 2 km s-1, converging to the hot core and following the magnetic field distribution. We compare the velocity field and the magnetic field derived from the SMA observations with magnetohydrodynamic simulations of star-forming regions dominated by gravity. This comparison allows us to show how the gas falls in from the larger-scale extended dense core (˜0.1 pc) of NGC 6334 V toward the higher-density hot core region (˜0.02 pc) through two distinctive converging flows dragging the magnetic field, whose strength seems to have been overcome by gravity.

  8. A multitrait (ADHD-IN, ADHD-HI, ODD toward adults, academic and social competence) by multisource (mothers and fathers) evaluation of the invariance and convergent/discriminant validity of the Child and Adolescent Disruptive Behavior Inventory with Thai adolescents.

    Science.gov (United States)

    Burns, G Leonard; Desmul, Chris; Walsh, James A; Silpakit, Chatchawan; Ussahawanitchakit, Phapruke

    2009-12-01

    Confirmatory factor analysis was used with a multitrait (attention-deficit/hyperactivity disorder-inattention, attention-deficit/hyperactivity disorder-hyperactivity/impulsivity, oppositional defiant disorder toward adults, academic competence, and social competence) by multisource (mothers and fathers) matrix to test the invariance and convergent/discriminant validity of the 5-factor model between mothers' and fathers' ratings of Thai adolescents (Year 1: n = 872; Year 2: n = 903; Year 3: n = 700; Year 4: n = 984) with the Child and Adolescent Disruptive Behavior Inventory (G. L. Burns, T. Taylor, & J. Rusby, 2001). The results showed equality of like-item loadings, intercepts, and residuals, as well as like-factor variances, covariances, and means between mothers' and fathers' ratings within each of the 4 yearly samples. In addition, the between-parent factor correlations showed convergent and discriminant validity with the within-parent factor correlations, showing discriminant validity for each year as well. These results for Thai adolescents and similar results (G. L. Burns et al., 2008) for mothers' and fathers' ratings of Brazilian, Thai, and American children provide broader support for the construct validity of the scale. The confirmatory factor analysis invariance and convergent/discriminant validity procedure with multiple sources is considered to provide a much more sophisticated procedure to evaluate the construct validity of attention-deficit/hyperactivity disorder and oppositional defiant disorder rating scales than a single-source approach.

  9. Weak Convergence and Weak Convergence

    Directory of Open Access Journals (Sweden)

    Narita Keiko

    2015-09-01

    Full Text Available In this article, we deal with weak convergence on sequences in real normed spaces, and weak* convergence on sequences in dual spaces of real normed spaces. In the first section, we proved some topological properties of dual spaces of real normed spaces. We used these theorems for proofs of Section 3. In Section 2, we defined weak convergence and weak* convergence, and proved some properties. By RNS_Real Mizar functor, real normed spaces as real number spaces already defined in the article [18], we regarded sequences of real numbers as sequences of RNS_Real. So we proved the last theorem in this section using the theorem (8 from [25]. In Section 3, we defined weak sequential compactness of real normed spaces. We showed some lemmas for the proof and proved the theorem of weak sequential compactness of reflexive real Banach spaces. We referred to [36], [23], [24] and [3] in the formalization.

  10. Convergent Aeronautics Solutions Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Convergent Aeronautics Solutions (CAS) Project uses short-duration activities to establish early-stage concept and technology feasibility for high-potential...

  11. Student Self-Regulated Learning in an Urban High School: Predictive Validity and Relations between Teacher Ratings and Student Self-Reports

    Science.gov (United States)

    Cleary, Timothy J.; Callan, Gregory L.

    2014-01-01

    This study examined the predictive validity of a teacher rating scale called the Self-Regulation Strategy Inventory-Teacher Rating Scale (SRSI-TRS) and its level of convergence with several student self-report measures of self-regulated learning (SRL). Eighty-seven high school students enrolled in one of four sections of a mathematics course in an…

  12. Construct validity of Comprehensive High-Level Activity Mobility Predictor (CHAMP for male servicemembers with traumatic lower-limb loss

    Directory of Open Access Journals (Sweden)

    Robert S. Gailey, PhD, PT

    2013-10-01

    Full Text Available This study examined the convergent construct validity of a new performance-based assessment instrument called the Comprehensive High-Level Activity Mobility Predictor (CHAMP as a measure of high-level mobility in servicemembers (SMs with traumatic lower-limb loss (LLL. The study was completed by 118 SMs. Convergent construct validity of the CHAMP was established using the 6-minute walk test (6MWT as a measure of overall mobility and physical function and the Amputee Mobility Predictor (AMP as a measure of basic prosthetic mobility. The known group methods construct validity examined disparities in high-level mobility capability among SMs with different levels of LLL. The CHAMP score demonstrated a strong positive relationship between 6MWT distance (r = 0.80, p < 0.001 and AMP score (r = 0.87, p < 0.001, respectively. In addition, the CHAMP can discriminate between different levels of LLL. Study findings support the CHAMP as a valid performance-based assessment instrument of high-level mobility for SMs with traumatic LLL.

  13. Convergent evolution of highly reduced fruiting bodies in Pezizomycotina suggests key adaptations to the bee habitat.

    Science.gov (United States)

    Wynns, Anja Amtoft

    2015-07-21

    cyst are both shown to have evolved convergently within the bee habitat. The convergent evolution of these unusual ascocarps is hypothesized to be adaptive for bee-mediated dispersal. Elucidating the dispersal strategies of these fungal symbionts contributes to our understanding of their interaction with bees and provides insight into the factors which potentially drive the evolution of reduced ascocarps in Pezizomycotina.

  14. Ecological convergence in a rocky intertidal shore metacommunity despite high spatial variability in recruitment regimes.

    Science.gov (United States)

    Caro, Andrés U; Navarrete, Sergio A; Castilla, Juan Carlos

    2010-10-26

    In open ecological systems, community structure can be determined by physically modulated processes such as the arrival of individuals from a regional pool and by local biological interactions. There is debate centering on whether niche differentiation and local interactions among species are necessary to explain macroscopic community patterns or whether the patterns can be generated by the neutral interplay of dispersal and stochastic demography among ecologically identical species. Here we evaluate how much of the observed spatial variation within a rocky intertidal metacommunity along 800 km of coastline can be explained by drift in the structure of recruits across 15 local sites. Our results show that large spatial changes in recruitment do not explain the observed spatial variation in adult local structure and that, in comparison with the large drift in structure of recruits, local adult communities converged to a common, although not unique, structure across the region. Although there is no unique adult community structure in the entire region, the observed variation represents only a small subset of the possible structures that would be expected from passive recruitment drift. Thus, in this diverse system our results do not support the idea that rocky intertidal metacommunities are structured by neutral mechanisms.

  15. 70% efficiency of bistate molecular machines explained by information theory, high dimensional geometry and evolutionary convergence

    Science.gov (United States)

    Schneider, Thomas D.

    2010-01-01

    The relationship between information and energy is key to understanding biological systems. We can display the information in DNA sequences specifically bound by proteins by using sequence logos, and we can measure the corresponding binding energy. These can be compared by noting that one of the forms of the second law of thermodynamics defines the minimum energy dissipation required to gain one bit of information. Under the isothermal conditions that molecular machines function this is joules per bit ( is Boltzmann's constant and T is the absolute temperature). Then an efficiency of binding can be computed by dividing the information in a logo by the free energy of binding after it has been converted to bits. The isothermal efficiencies of not only genetic control systems, but also visual pigments are near 70%. From information and coding theory, the theoretical efficiency limit for bistate molecular machines is ln 2 = 0.6931. Evolutionary convergence to maximum efficiency is limited by the constraint that molecular states must be distinct from each other. The result indicates that natural molecular machines operate close to their information processing maximum (the channel capacity), and implies that nanotechnology can attain this goal. PMID:20562221

  16. 70% efficiency of bistate molecular machines explained by information theory, high dimensional geometry and evolutionary convergence.

    Science.gov (United States)

    Schneider, Thomas D

    2010-10-01

    The relationship between information and energy is key to understanding biological systems. We can display the information in DNA sequences specifically bound by proteins by using sequence logos, and we can measure the corresponding binding energy. These can be compared by noting that one of the forms of the second law of thermodynamics defines the minimum energy dissipation required to gain one bit of information. Under the isothermal conditions that molecular machines function this is [Formula in text] joules per bit (kB is Boltzmann's constant and T is the absolute temperature). Then an efficiency of binding can be computed by dividing the information in a logo by the free energy of binding after it has been converted to bits. The isothermal efficiencies of not only genetic control systems, but also visual pigments are near 70%. From information and coding theory, the theoretical efficiency limit for bistate molecular machines is ln 2=0.6931. Evolutionary convergence to maximum efficiency is limited by the constraint that molecular states must be distinct from each other. The result indicates that natural molecular machines operate close to their information processing maximum (the channel capacity), and implies that nanotechnology can attain this goal.

  17. IT Convergence and Security 2012

    CERN Document Server

    Chung, Kyung-Yong

    2013-01-01

    The proceedings approaches the subject matter with problems in technical convergence and convergences of security technology. This approach is new because we look at new issues that arise from techniques converging. The general scope of the proceedings content is convergence security and the latest information technology. The intended readership are societies, enterprises, and research institutes, and intended content level is mid- to highly educated personals. The most important features and benefits of the proceedings are the introduction of the most recent information technology and its related ideas, applications and problems related to technology convergence, and its case studies and finally an introduction of converging existing security techniques through convergence security. Overall, through the proceedings, authors will be able to understand the most state of the art information strategies and technologies of convergence security.

  18. Adaptation and convergent evolution within the Jamesonia-Eriosorus complex in high-elevation biodiverse Andean hotspots.

    Science.gov (United States)

    Sánchez-Baracaldo, Patricia; Thomas, Gavin H

    2014-01-01

    The recent uplift of the tropical Andes (since the late Pliocene or early Pleistocene) provided extensive ecological opportunity for evolutionary radiations. We test for phylogenetic and morphological evidence of adaptive radiation and convergent evolution to novel habitats (exposed, high-altitude páramo habitats) in the Andean fern genera Jamesonia and Eriosorus. We construct time-calibrated phylogenies for the Jamesonia-Eriosorus clade. We then use recent phylogenetic comparative methods to test for evolutionary transitions among habitats, associations between habitat and leaf morphology, and ecologically driven variation in the rate of morphological evolution. Páramo species (Jamesonia) display morphological adaptations consistent with convergent evolution in response to the demands of a highly exposed environment but these adaptations are associated with microhabitat use rather than the páramo per se. Species that are associated with exposed microhabitats (including Jamesonia and Eriorsorus) are characterized by many but short pinnae per frond whereas species occupying sheltered microhabitats (primarily Eriosorus) have few but long pinnae per frond. Pinnae length declines more rapidly with altitude in sheltered species. Rates of speciation are significantly higher among páramo than non-páramo lineages supporting the hypothesis of adaptation and divergence in the unique Páramo biodiversity hotspot.

  19. Evidence for the Convergence Model: The Emergence of Highly Pathogenic Avian Influenza (H5N1) in Viet Nam.

    Science.gov (United States)

    Saksena, Sumeet; Fox, Jefferson; Epprecht, Michael; Tran, Chinh C; Nong, Duong H; Spencer, James H; Nguyen, Lam; Finucane, Melissa L; Tran, Vien D; Wilcox, Bruce A

    2015-01-01

    Building on a series of ground breaking reviews that first defined and drew attention to emerging infectious diseases (EID), the 'convergence model' was proposed to explain the multifactorial causality of disease emergence. The model broadly hypothesizes disease emergence is driven by the co-incidence of genetic, physical environmental, ecological, and social factors. We developed and tested a model of the emergence of highly pathogenic avian influenza (HPAI) H5N1 based on suspected convergence factors that are mainly associated with land-use change. Building on previous geospatial statistical studies that identified natural and human risk factors associated with urbanization, we added new factors to test whether causal mechanisms and pathogenic landscapes could be more specifically identified. Our findings suggest that urbanization spatially combines risk factors to produce particular types of peri-urban landscapes with significantly higher HPAI H5N1 emergence risk. The work highlights that peri-urban areas of Viet Nam have higher levels of chicken densities, duck and geese flock size diversities, and fraction of land under rice or aquaculture than rural and urban areas. We also found that land-use diversity, a surrogate measure for potential mixing of host populations and other factors that likely influence viral transmission, significantly improves the model's predictability. Similarly, landscapes where intensive and extensive forms of poultry production overlap were found at greater risk. These results support the convergence hypothesis in general and demonstrate the potential to improve EID prevention and control by combing geospatial monitoring of these factors along with pathogen surveillance programs.

  20. Evidence for the Convergence Model: The Emergence of Highly Pathogenic Avian Influenza (H5N1 in Viet Nam.

    Directory of Open Access Journals (Sweden)

    Sumeet Saksena

    Full Text Available Building on a series of ground breaking reviews that first defined and drew attention to emerging infectious diseases (EID, the 'convergence model' was proposed to explain the multifactorial causality of disease emergence. The model broadly hypothesizes disease emergence is driven by the co-incidence of genetic, physical environmental, ecological, and social factors. We developed and tested a model of the emergence of highly pathogenic avian influenza (HPAI H5N1 based on suspected convergence factors that are mainly associated with land-use change. Building on previous geospatial statistical studies that identified natural and human risk factors associated with urbanization, we added new factors to test whether causal mechanisms and pathogenic landscapes could be more specifically identified. Our findings suggest that urbanization spatially combines risk factors to produce particular types of peri-urban landscapes with significantly higher HPAI H5N1 emergence risk. The work highlights that peri-urban areas of Viet Nam have higher levels of chicken densities, duck and geese flock size diversities, and fraction of land under rice or aquaculture than rural and urban areas. We also found that land-use diversity, a surrogate measure for potential mixing of host populations and other factors that likely influence viral transmission, significantly improves the model's predictability. Similarly, landscapes where intensive and extensive forms of poultry production overlap were found at greater risk. These results support the convergence hypothesis in general and demonstrate the potential to improve EID prevention and control by combing geospatial monitoring of these factors along with pathogen surveillance programs.

  1. Validation of a RANS transition model using a high-order weighted compact nonlinear scheme

    Science.gov (United States)

    Tu, GuoHua; Deng, XiaoGang; Mao, MeiLiang

    2013-04-01

    A modified transition model is given based on the shear stress transport (SST) turbulence model and an intermittency transport equation. The energy gradient term in the original model is replaced by flow strain rate to saving computational costs. The model employs local variables only, and then it can be conveniently implemented in modern computational fluid dynamics codes. The fifth-order weighted compact nonlinear scheme and the fourth-order staggered scheme are applied to discrete the governing equations for the purpose of minimizing discretization errors, so as to mitigate the confusion between numerical errors and transition model errors. The high-order package is compared with a second-order TVD method on simulating the transitional flow of a flat plate. Numerical results indicate that the high-order package give better grid convergence property than that of the second-order method. Validation of the transition model is performed for transitional flows ranging from low speed to hypersonic speed.

  2. Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau

    Science.gov (United States)

    Wang, Guo-Dong; Fan, Ruo-Xi; Zhai, Weiwei; Liu, Fei; Wang, Lu; Zhong, Li; Wu, Hong; Yang, He-Chuan; Wu, Shi-Fang; Zhu, Chun-Ling; Li, Yan; Gao, Yun; Ge, Ri-Li; Wu, Chung-I; Zhang, Ya-Ping

    2014-01-01

    The high-altitude hypoxic environment represents one of the most extreme challenges for mammals. Previous studies of humans on the Tibetan plateau and in the Andes Mountains have identified statistical signatures of selection in different sets of loci. Here, we first measured the hemoglobin levels in village dogs from Tibet and those from Chinese lowlands. We found that the hemoglobin levels are very similar between the two groups, suggesting that Tibetan dogs might share similar adaptive strategies as the Tibetan people. Through a whole-genome sequencing approach, we have identified EPAS1 and HBB as candidate genes for the hypoxic adaptation on the Tibetan plateau. The population genetic analysis shows a significant convergence between humans and dogs in Tibet. The similarities in the sets of loci that exhibit putative signatures of selection and the hemoglobin levels between humans and dogs of the same environment, but not between human populations in different regions, suggests an extraordinary landscape of convergent evolution between human beings and their best friend on the Tibetan plateau. PMID:25091388

  3. Field testing of a convergent array of acoustic Doppler profilers for high-resolution velocimetry in energetic tidal currents

    Energy Technology Data Exchange (ETDEWEB)

    Harding, Samuel F.; Sellar, Brian; Richmond, Marshall C.

    2016-04-25

    An array of single-beam acoustic Doppler profilers has been developed for the high resolution measurement of three-dimensional tidal flow velocities and subsequently tested in an energetic tidal site. This configuration has been developed to increase spatial resolution of velocity measurements in comparison to conventional acoustic Doppler profilers (ADPs) which characteristically use divergent acoustic beams emanating from a single instrument. This is achieved using geometrically convergent acoustic beams creating a sample volume at the focal point of 0.03 m3. Away from the focal point, the array is also able to simultaneously reconstruct three-dimensional velocity components in a profile throughout the water column, and is referred to herein as a convergent-beam acoustic Doppler profiler (C-ADP). Mid-depth profiling is achieved through integration of the sensor platform with the operational commercial-scale Alstom 1MW DeepGen-IV Tidal Turbine deployed at the European Marine Energy Center, Orkney Isles, UK. This proof-of-concept paper outlines the C-ADP system configuration and comparison to measurements provided by co-installed reference instrumentation.

  4. Convergence in spectral forward modelling: Binominal series solutions vs. direct integral solutions at high degrees - spherical and ellipsoidal case

    Science.gov (United States)

    Rexer, Moritz; Claessens, Sten; Hirt, Christian

    2016-04-01

    The number of relevant terms of binominal series expansions used in spectral forward modelling of the gravitational potential is known to rise substantially as the resolution of the models increases. Here, we investigate and compare the binominal series expansions in forward modelling w.r.t. a sphere and w.r.t. an ellipsoid (Claessens and Hirt, 2013) in view of high degree forward modelling (d/o 10800). The series in each case depend on different parameters - such as elevation of the topographic function or ellipsoidal radius/co-latitude - and reveal different maximum orders of truncation for a 1% convergence level (=relative error). The results are verified in a real data scenario up to d/o 5400 by spot-checks using direct integral solutions that do not depend on binomial series expansions. As a conclusion, our study demonstrates that for d/o 10800 modelling up to 30 terms of the binominal series accounting for the radial integral are needed within the spherical and the ellipsoidal case, while up to 60 terms are needed for the binominal series accounting for the oblateness of Earth in the ellipsoidal case for a convergence at the 1% level. References: Claessens, S.J.; Hirt, C.: Ellipsoidal topographic potential - new solutions for spectral forward gravity modelling of topography with respect to a reference ellipsoid; Journal of Geophysical Research (JGR) - Solid Earth, Vol. 118, DOI: 10.1002/2013JB010457, 2013.

  5. Nonaccommodative convergence excess.

    Science.gov (United States)

    von Noorden, G K; Avilla, C W

    1986-01-15

    Nonaccommodative convergence excess is a condition in which a patient has orthotropia or a small-angle esophoria or esotropia at distance and a large-angle esotropia at near, not significantly reduced by the addition of spherical plus lenses. The AC/A ratio, determined with the gradient method, is normal or subnormal. Tonic convergence is suspected of causing the convergence excess in these patients. Nonaccommodative convergence excess must be distinguished from esotropia with a high AC/A ratio and from hypoaccommodative esotropia. In 24 patients treated with recession of both medial recti muscles with and without posterior fixation or by posterior fixation alone, the mean correction of esotropia was 7.4 prism diopters at distance and 17 prism diopters at near.

  6. Neural convergence for language comprehension and grammatical class production in highly proficient bilinguals is independent of age of acquisition.

    Science.gov (United States)

    Consonni, Monica; Cafiero, Riccardo; Marin, Dario; Tettamanti, Marco; Iadanza, Antonella; Fabbro, Franco; Perani, Daniela

    2013-05-01

    In bilinguals, native (L1) and second (L2) languages are processed by the same neural resources that can be modulated by age of second language acquisition (AOA), proficiency level, and daily language exposure and usage. AOA seems to particularly affect grammar processing, where a complete neural convergence has been shown only in bilinguals with parallel language acquisition from birth. Despite the fact that proficiency-related neuroanatomical differences have been well documented in language comprehension (LC) and production, few reports have addressed the influence of language exposure. A still unanswered question pertains to the role of AOA, when proficiency is comparably high across languages, with respect to its modulator effects both on LC and production. Here, we evaluated with fMRI during sentence comprehension and verb and noun production tasks, two groups of highly proficient bilinguals only differing in AOA. One group learned Italian and Friulian in parallel from birth, whereas the second group learned Italian between 3 and 6 years. All participants were highly exposed to both languages, but more to Italian than Friulian. The results indicate a complete overlap of neural activations for the comprehension of both languages, not only in bilinguals from birth, but also in late bilinguals. A slightly extra activation in the left thalamus for the less-exposed language confirms that exposure may affect language processing. Noteworthy, we report for the first time that, when proficiency and exposure are kept high, noun and verb production recruit the same neural networks for L1 and L2, independently of AOA. These results support the neural convergence hypothesis. Copyright © 2012 Elsevier Ltd. All rights reserved.

  7. Convergent chaos

    Science.gov (United States)

    Pradas, Marc; Pumir, Alain; Huber, Greg; Wilkinson, Michael

    2017-07-01

    Chaos is widely understood as being a consequence of sensitive dependence upon initial conditions. This is the result of an instability in phase space, which separates trajectories exponentially. Here, we demonstrate that this criterion should be refined. Despite their overall intrinsic instability, trajectories may be very strongly convergent in phase space over extremely long periods, as revealed by our investigation of a simple chaotic system (a realistic model for small bodies in a turbulent flow). We establish that this strong convergence is a multi-facetted phenomenon, in which the clustering is intense, widespread and balanced by lacunarity of other regions. Power laws, indicative of scale-free features, characterize the distribution of particles in the system. We use large-deviation and extreme-value statistics to explain the effect. Our results show that the interpretation of the ‘butterfly effect’ needs to be carefully qualified. We argue that the combination of mixing and clustering processes makes our specific model relevant to understanding the evolution of simple organisms. Lastly, this notion of convergent chaos, which implies the existence of conditions for which uncertainties are unexpectedly small, may also be relevant to the valuation of insurance and futures contracts.

  8. Validation of the High-Risk Pregnancy Stress Scale in a sample of hospitalized Greek high-risk pregnant women.

    Science.gov (United States)

    Gourounti, Kleanthi; Karpathiotaki, Natassa; Karapanou, Vassiliki; Antzaklis, Panos; Daskalakis, Georgios

    2016-01-01

    The aim of the authors in this study was to determine the psychometric properties of the Greek adaptation of the High-Risk Pregnancy Stress Scale (HRPSS) in a sample of high-risk hospitalized pregnant women. The sample consisted of 133 high-risk pregnant women with gestational age from 9 to 37 weeks. Data were collected between February and June of 2014. HRPSS was "forward-backward" translated from English to Greek. Principal axis factoring with promax rotation was used to test the factor structure of the HRPSS. Measures of state anxiety (STAI) and depressive symptoms (EPDS) were used to assess the convergent validity of the HRPSS. Exploratory factor analysis suggested three factors: concerns of pregnancy, movement restriction, and isolation and restriction of external activities. Construct validity was confirmed by computing correlations between the HRPSS and constructions of anxiety and depressive symptoms. Internal consistency reliability was satisfactory (α = 0.813). The original factor structure of the HRPSS was only partly replicated. The results of the exploratory factor analysis suggested that a three-factor solution instead of a two-factor solution would be the most adequate. The HRPSS is an appropriate measure for assessing the levels of concerns regarding pregnancy outcome, movement restriction, isolation, and external activity restrictions in Greek high-risk pregnant women.

  9. Convergence of Sample Eigenvalues, Eigenvectors, and Principal Component Scores for Ultra-High Dimensional Data.

    Science.gov (United States)

    Lee, Seunggeun; Zou, Fei; Wright, Fred A

    2014-06-01

    The development of high-throughput biomedical technologies has led to increased interest in the analysis of high-dimensional data where the number of features is much larger than the sample size. In this paper, we investigate principal component analysis under the ultra-high dimensional regime, where both the number of features and the sample size increase as the ratio of the two quantities also increases. We bridge the existing results from the finite and the high-dimension low sample size regimes, embedding the two regimes in a more general framework. We also numerically demonstrate the universal application of the results from the finite regime.

  10. MHD Flow of an Incompressible Viscous Fluid through Convergent or Divergent Channels in Presence of a High Magnetic Field

    Directory of Open Access Journals (Sweden)

    Reza Hosseini

    2012-01-01

    Full Text Available The flow of an incompressible electrically conducting viscous fluid in convergent or divergent channels under the influence of an externally applied homogeneous magnetic field is studied both analytically and numerically. Navier-Stokes equations of fluid mechanics and Maxwell’s electromagnetism equations are reduced into highly non-linear ordinary differential equation. The resulting non-linear equation has been solved analytically using a very efficient technique, namely, differential transform method (DTM. The DTM solution is compared with the results obtained by a numerical method (shooting method, coupled with fourth-order Runge-Kutta scheme. The plots have revealed the physical characteristics of flow by changing angles of the channel, Hartmann and Reynolds numbers.

  11. A new selection method for high-dimensionial instrumental setting: application to the Growth Rate convergence hypothesis

    CERN Document Server

    Mougeot, Mathilde; Tribouley, Karine

    2011-01-01

    This paper investigates the problem of selecting variables in regression-type models for an "instrumental" setting. Our study is motivated by empirically verifying the conditional convergence hypothesis used in the economical literature concerning the growth rate. To avoid unnecessary discussion about the choice and the pertinence of instrumental variables, we embed the model in a very high dimensional setting. We propose a selection procedure with no optimization step called LOLA, for Learning Out of Leaders with Adaptation. LOLA is an auto-driven algorithm with two thresholding steps. The consistency of the procedure is proved under sparsity conditions and simulations are conducted to illustrate the practical good performances of LOLA. The behavior of the algorithm is studied when instrumental variables are artificially added without a priori significant connection to the model. Using our algorithm, we provide a solution for modeling the link between the growth rate and the initial level of the gross domest...

  12. Measurements for validation of high voltage underground cable modelling

    DEFF Research Database (Denmark)

    Bak, Claus Leth; Gudmundsdottir, Unnur Stella; Wiechowski, Wojciech Tomasz

    2009-01-01

    This paper discusses studies concerning cable modelling for long high voltage AC cable lines. In investigating the possibilities of using long cables instead of overhead lines, the simulation results must be trustworthy. Therefore a model validation is of great importance. This paper describes...

  13. High-throughput Phenotyping and Genomic Selection: The Frontiers of Crop Breeding Converge

    Institute of Scientific and Technical Information of China (English)

    Llorenc Cabrera-Bosquet; José Crossa; Jarislav von Zitzewitz; Maria Dolors Serret; José Luis Araus

    2012-01-01

    Genomic selection (GS) and high-throughput phenotyping have recently been captivating the interest of the crop breeding community from both the public and private sectors world-wide.Both approaches promise to revolutionize the prediction of complex traits,including growth,yield and adaptation to stress.Whereas high-throughput phenotyping may help to improve understanding of crop physiology,most powerful techniques for high-throughput field phenotyping are empirical rather than analytical and comparable to genomic selection.Despite the fact that the two methodological approaches represent the extremes of what is understood as the breeding process (phenotype versus genome),they both consider the targeted traits (e.g.grain yield,growth,phenology,plant adaptation to stress) as a black box instead of dissecting them as a set of secondary traits (i.e.physiological) putatively related to the target trait.Both GS and high-throughput phenotyping have in common their empirical approach enabling breeders to use genome profile or phenotype without understanding the underlying biology.This short review discusses the main aspects of both approaches and focuses on the case of genomic selection of maize flowering traits and near-infrared spectroscopy (NIRS) and plant spectral reflectance as high-throughput field phenotyping methods for complex traits such as crop growth and yield.

  14. Validation of two conceptualizations of fragile self-esteem: Contingent high self-esteem and incongruent high self-esteem

    Directory of Open Access Journals (Sweden)

    Bodroža Bojana

    2014-01-01

    Full Text Available The aim of this research was to validate two aspects of fragile high self-esteem: a combination of contingent and high (explicit self-esteem and a combination of high explicit and low implicit self-esteem (i.e. incongruent high self-esteem, as well as to examine the relationship between these aspects of fragile self-esteem and narcissism. No convergence was found between contingent high and incongruent high self-esteem. The result was consistent regardless of the technique of measurement of implicit self-esteem. There was a limited evidence that individuals with narcissistic personality characteristics were characterized by high self-esteem contingent upon competences, but not by a combination of high explicit and low implicit self-esteem, as an aspect of fragile self-esteem. Also, individuals with low selfesteem more contingent upon competences showed higher levels of narcissistic characteristics than those who were not contingent in this domain. [Projekat Ministarstva nauke Republike Srbije, br.179034: From encouraging initiative, cooperation and creativity in education to new roles and identities in society i br. 47008: Improving he quality and accessibility of education in modernization processes in Serbia

  15. Comparison of social cognitive functioning in schizophrenia and high functioning autism: more convergence than divergence

    OpenAIRE

    Couture, S. M.; Penn, D. L.; Losh, M.; Adolphs, R.; Hurley, R; Piven, J.

    2010-01-01

    Background: Individuals with schizophrenia and individuals with high-functioning autism (HFA) seem to share some social, behavioral and biological features. Although marked impairments in social cognition have been documented in both groups, little empirical work has compared the social cognitive functioning of these two clinical groups. Method: Forty-four individuals with schizophrenia, 36 with HFA and 41 non-clinical controls completed a battery of social cognitive measures that have been l...

  16. The management of esotropia with high AC/A ratio (convergence excess).

    Science.gov (United States)

    Pratt-Johnson, J A; Tillson, G

    1985-01-01

    This paper reviews the long-term follow-up of esotropia with a high AC/A ratio defined as an increase of 20 delta or more of the esotropia at near compared with distance with the full optical correction of any refractive error in place. Ninety-nine patients were studied for an average follow-up of eight years. Eighty-six achieved fusion but only five achieved central fusion. Forty-five were treated with bifocals. No significant difference in the sensory results were recorded in those patients wearing bifocals compared with those who did not wear bifocals. No patient had miotic therapy for more than a few months. The suppression characteristic of this condition is reviewed.

  17. Evolution of HIV treatment guidelines in high- and low-income countries: converging recommendations.

    Science.gov (United States)

    Richardson, Eugene T; Grant, Philip M; Zolopa, Andrew R

    2014-03-01

    Over the past 15 years, antiretroviral treatment guidelines for HIV infection have evolved significantly, reflecting the major advances in this therapeutic area. Evidenced-based recommendations have largely replaced expert opinion, while diagnostic monitoring and therapeutic interventions have become more sophisticated and effective. Just 10 years ago, there was a marked difference in access to antiretroviral therapy for patients in wealthy and impoverished countries. The increasing availability of therapy across the globe, however, has made it possible for international guidelines to resemble more closely those in high-income countries. This article compares the evolution of antiretroviral therapy treatment guidelines from the United States Department of Health and Human Services and the World Health Organization, focusing on when to initiate ART in asymptomatic patients and in those with an opportunistic infection; initial regimens in the general population and in special populations; when to change and what to change; and laboratory monitoring.

  18. The Convergence of High Performance Computing and Large Scale Data Analytics

    Science.gov (United States)

    Duffy, D.; Bowen, M. K.; Thompson, J. H.; Yang, C. P.; Hu, F.; Wills, B.

    2015-12-01

    As the combinations of remote sensing observations and model outputs have grown, scientists are increasingly burdened with both the necessity and complexity of large-scale data analysis. Scientists are increasingly applying traditional high performance computing (HPC) solutions to solve their "Big Data" problems. While this approach has the benefit of limiting data movement, the HPC system is not optimized to run analytics, which can create problems that permeate throughout the HPC environment. To solve these issues and to alleviate some of the strain on the HPC environment, the NASA Center for Climate Simulation (NCCS) has created the Advanced Data Analytics Platform (ADAPT), which combines both HPC and cloud technologies to create an agile system designed for analytics. Large, commonly used data sets are stored in this system in a write once/read many file system, such as Landsat, MODIS, MERRA, and NGA. High performance virtual machines are deployed and scaled according to the individual scientist's requirements specifically for data analysis. On the software side, the NCCS and GMU are working with emerging commercial technologies and applying them to structured, binary scientific data in order to expose the data in new ways. Native NetCDF data is being stored within a Hadoop Distributed File System (HDFS) enabling storage-proximal processing through MapReduce while continuing to provide accessibility of the data to traditional applications. Once the data is stored within HDFS, an additional indexing scheme is built on top of the data and placed into a relational database. This spatiotemporal index enables extremely fast mappings of queries to data locations to dramatically speed up analytics. These are some of the first steps toward a single unified platform that optimizes for both HPC and large-scale data analysis, and this presentation will elucidate the resulting and necessary exascale architectures required for future systems.

  19. Halogenated pollutants in terrestrial and aquatic bird eggs: converging patterns of pollutant profiles, and impacts and risks from high levels.

    Science.gov (United States)

    Bouwman, Hindrik; Viljoen, Ignatius M; Quinn, Laura P; Polder, Anuschka

    2013-10-01

    We investigated the presence, levels, relationships, and risks of HCHs, DDTs, chlordanes, mirex, PCBs, and brominated flame retardants (BFRs) in terrestrial and aquatic bird eggs from an area in South Africa where DDT is used for malaria control. We found one of the highest ΣDDT levels reported this century; 13,000 ng/g wm (wet mass) in Grey Heron eggs which exceeds critical levels for reproductive success (3000 ng/g wm) calculated for Brown Pelicans, with a no-effect level estimated at 500 ng/g wm. Even higher ΣDDT levels at 16,000 ng/g wm were found in House Sparrow eggs (possibly the highest ever recorded for sparrows), with a maximum of 24,400 ng/g wm. Significant eggshell thinning in Cattle Egrets (33% between thickest and thinnest) was associated with increased levels of p,p'-DDT and p,p'-DDE. There were indications of unknown use of DDT and lindane. Relative to DDT, PCBs and BFRs levels were quite low. Ordinated data showed that different terrestrial pollutant profiles converged to a homogenised aquatic profile. Converging profiles, high levels of DDT in heron and sparrow eggs, and thinning eggs shells, indicate risk and impacts at release, in the aquatic environment, and in between. If characteristic life-strategies of birds in warm areas (e.g. longer-lived and fewer eggs per clutch) increases the risk compared with similar birds living in colder regions when both experience the same environmental pollutant levels, then malaria control using DDT probably has more significant impacts on biota than previously realised. Therefore, risk assessment and modelling without hard data may miss crucial impacts and risks, as the chemical use patterns and ecologies in Africa and elsewhere may differ from the conditions and assumptions of existing risk assessment and modelling parameters. Consideration of other findings associated with DDT from the same area (intersex in fish and urogental birth defects in baby boys), together with the findings of this study (high

  20. Validation of AIRS high-resolution stratospheric temperature retrievals

    Science.gov (United States)

    Meyer, Catrin I.; Hoffmann, Lars

    2014-10-01

    This paper focuses on stratospheric temperature observations by the Atmospheric InfraRed Sounder (AIRS) aboard NASA's Aqua satellite. We validate a nine-year record (2003 - 2011) of data retrieved with a scientific retrieval processor independent from the operational processor operated by NASA. The retrieval discussed here provides stratospheric temperature profiles for each individual AIRS footprint and has nine times better horizontal sampling than the operational data provided by NASA. The high-resolution temperature data are considered optimal for for gravity wave studies. For validation the high-resolution retrieval data are compared with results from the AIRS operational Level-2 data and the ERA-Interim meteorological reanalysis. Due to the large amount of data we performed statistical comparisons of monthly zonal mean cross-sections and time series. The comparisons show that the high-resolution temperature data are in good agreement with the validation data sets. The bias in the zonal averages is mostly within ±2K. The bias reaches a maximum of 7K to ERA-Interim and 4K to the AIRS operational data at the stratopause, it is related to the different resolutions of the data sets. Variability is nearly the same in all three data sets, having maximum standard deviations around the polar vortex in the mid and upper stratosphere. The validation presented here indicates that the high-resolution temperature retrievals are well-suited for scientific studies. In particular, we expect that they will become a valuable asset for future studies of stratospheric gravity waves.

  1. Teste de Inteligência R1-Forma B e G36: evidência de validade convergente R1-Forma B Intelligence Test and G36: evidences of convergent validity

    Directory of Open Access Journals (Sweden)

    Acácia A. Angeli dos Santos

    2005-08-01

    Full Text Available Considerando-se a relevância de se obter medidas confiáveis para a avaliação da inteligência, este estudo foi proposto com o objetivo de verificar a validade convergente entre os testes R1-Forma B e o G36. Participaram 78 alunos que freqüentavam o Telecurso do ensino médio, com idades entre 15 e 64 anos (média = 36,84; DP = 10,10, sendo 27 (34,6% do sexo feminino e 51 (65,4% do masculino. Os resultados apontaram para uma alta correlação entre os testes (r = 0,80, o que permite afirmar que medem o mesmo construto. Apesar disso, a hipótese de que o G36 estaria mais correlacionado com o Fator 2 do R-1 não pôde ser confirmada. Esse dado pode indicar que o G36 não seja unidimensional e se relacione mais com a inteligência cristalizada do que com o fator g.Considering the relevance of obtaining trustful measurement for the evaluation of intelligence, this study aimed at verifying the convergent validity between the R1-Forma B and the G36 tests. 78 students of both gender (34,6% female and 65,4% male, aged from 15 to 64 years old (mean = 36,84; SD = 10,10 and attending to the high school Telecurso were studied. The results indicated a high correlation between tests (r = 0.80, what allowed for the statement that they measure similar constructs. Nevertheless, the hypothesis that G36 would be more correlated with Factor 2 of R-1 could not be confirmed. This information suggests that the G36 is not unidimensional and is more related to crystallized intelligence than the g factor.

  2. High-throughput analysis of 19 endogenous androgenic steroids by ultra-performance convergence chromatography tandem mass spectrometry.

    Science.gov (United States)

    Quanson, Jonathan L; Stander, Marietjie A; Pretorius, Elzette; Jenkinson, Carl; Taylor, Angela E; Storbeck, Karl-Heinz

    2016-09-15

    11-Oxygenated steroids such as 11-ketotestosterone and 11-ketodihydrotestosterone have recently been shown to play a putative role in the development and progression of castration resistant prostate cancer. In this study we report on the development of a high throughput ultra-performance convergence chromatography tandem mass spectrometry (UPC(2)-MS/MS) method for the analysis of thirteen 11-oxygenated and six canonical C19 steroids isolated from a cell culture matrix. Using an Acquity UPC(2) BEH 2-EP column we found that UPC(2) resulted in superior selectivity, increased chromatographic efficiency and a scattered elution order when compared to conventional reverse phase ultra-performance liquid chromatography (UPLC). Furthermore, there was a significant improvement in sensitivity (5-50 times). The lower limits of quantification ranged between 0.01-10ngmL(-1), while the upper limit of quantification was 100ngmL(-1) for all steroids. Accuracy, precision, intra-day variation, recovery, matrix effects and process efficiency were all evaluated and found to be within acceptable limits. Taken together we show that the increased power of UPC(2)-MS/MS allows the analyst to complete in vitro assays at biologically relevant concentrations for the first time and in so doing determine the routes of steroid metabolism which is vital for studies of androgen responsive cancers, such as prostate cancer, and could highlight new mechanisms of disease progression and new targets for cancer therapy. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Verification and validation guidelines for high integrity systems. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Hecht, H.; Hecht, M.; Dinsmore, G.; Hecht, S.; Tang, D. [SoHaR, Inc., Beverly Hills, CA (United States)

    1995-03-01

    High integrity systems include all protective (safety and mitigation) systems for nuclear power plants, and also systems for which comparable reliability requirements exist in other fields, such as in the process industries, in air traffic control, and in patient monitoring and other medical systems. Verification aims at determining that each stage in the software development completely and correctly implements requirements that were established in a preceding phase, while validation determines that the overall performance of a computer system completely and correctly meets system requirements. Volume I of the report reviews existing classifications for high integrity systems and for the types of errors that may be encountered, and makes recommendations for verification and validation procedures, based on assumptions about the environment in which these procedures will be conducted. The final chapter of Volume I deals with a framework for standards in this field. Volume II contains appendices dealing with specific methodologies for system classification, for dependability evaluation, and for two software tools that can automate otherwise very labor intensive verification and validation activities.

  4. Verification & Validation of High-Order Short-Characteristics-Based Deterministic Transport Methodology on Unstructured Grids

    Energy Technology Data Exchange (ETDEWEB)

    Azmy, Yousry [North Carolina State Univ., Raleigh, NC (United States); Wang, Yaqi [North Carolina State Univ., Raleigh, NC (United States)

    2013-12-20

    The research team has developed a practical, high-order, discrete-ordinates, short characteristics neutron transport code for three-dimensional configurations represented on unstructured tetrahedral grids that can be used for realistic reactor physics applications at both the assembly and core levels. This project will perform a comprehensive verification and validation of this new computational tool against both a continuous-energy Monte Carlo simulation (e.g. MCNP) and experimentally measured data, an essential prerequisite for its deployment in reactor core modeling. Verification is divided into three phases. The team will first conduct spatial mesh and expansion order refinement studies to monitor convergence of the numerical solution to reference solutions. This is quantified by convergence rates that are based on integral error norms computed from the cell-by-cell difference between the code’s numerical solution and its reference counterpart. The latter is either analytic or very fine- mesh numerical solutions from independent computational tools. For the second phase, the team will create a suite of code-independent benchmark configurations to enable testing the theoretical order of accuracy of any particular discretization of the discrete ordinates approximation of the transport equation. For each tested case (i.e. mesh and spatial approximation order), researchers will execute the code and compare the resulting numerical solution to the exact solution on a per cell basis to determine the distribution of the numerical error. The final activity comprises a comparison to continuous-energy Monte Carlo solutions for zero-power critical configuration measurements at Idaho National Laboratory’s Advanced Test Reactor (ATR). Results of this comparison will allow the investigators to distinguish between modeling errors and the above-listed discretization errors introduced by the deterministic method, and to separate the sources of uncertainty.

  5. Convergent Findings of Altered Functional and Structural Brain Connectivity in Individuals with High Functioning Autism: A Multimodal MRI Study.

    Science.gov (United States)

    Mueller, Sophia; Keeser, Daniel; Samson, Andrea C; Kirsch, Valerie; Blautzik, Janusch; Grothe, Michel; Erat, Okan; Hegenloh, Michael; Coates, Ute; Reiser, Maximilian F; Hennig-Fast, Kristina; Meindl, Thomas

    2013-01-01

    Brain tissue changes in autism spectrum disorders seem to be rather subtle and widespread than anatomically distinct. Therefore a multimodal, whole brain imaging technique appears to be an appropriate approach to investigate whether alterations in white and gray matter integrity relate to consistent changes in functional resting state connectivity in individuals with high functioning autism (HFA). We applied diffusion tensor imaging (DTI), voxel-based morphometry (VBM) and resting state functional connectivity magnetic resonance imaging (fcMRI) to assess differences in brain structure and function between 12 individuals with HFA (mean age 35.5, SD 11.4, 9 male) and 12 healthy controls (mean age 33.3, SD 9.0, 8 male). Psychological measures of empathy and emotionality were obtained and correlated with the most significant DTI, VBM and fcMRI findings. We found three regions of convergent structural and functional differences between HFA participants and controls. The right temporo-parietal junction area and the left frontal lobe showed decreased fractional anisotropy (FA) values along with decreased functional connectivity and a trend towards decreased gray matter volume. The bilateral superior temporal gyrus displayed significantly decreased functional connectivity that was accompanied by the strongest trend of gray matter volume decrease in the temporal lobe of HFA individuals. FA decrease in the right temporo-parietal region was correlated with psychological measurements of decreased emotionality. In conclusion, our results indicate common sites of structural and functional alterations in higher order association cortex areas and may therefore provide multimodal imaging support to the long-standing hypothesis of autism as a disorder of impaired higher-order multisensory integration.

  6. Convergent Findings of Altered Functional and Structural Brain Connectivity in Individuals with High Functioning Autism: A Multimodal MRI Study.

    Directory of Open Access Journals (Sweden)

    Sophia Mueller

    Full Text Available Brain tissue changes in autism spectrum disorders seem to be rather subtle and widespread than anatomically distinct. Therefore a multimodal, whole brain imaging technique appears to be an appropriate approach to investigate whether alterations in white and gray matter integrity relate to consistent changes in functional resting state connectivity in individuals with high functioning autism (HFA. We applied diffusion tensor imaging (DTI, voxel-based morphometry (VBM and resting state functional connectivity magnetic resonance imaging (fcMRI to assess differences in brain structure and function between 12 individuals with HFA (mean age 35.5, SD 11.4, 9 male and 12 healthy controls (mean age 33.3, SD 9.0, 8 male. Psychological measures of empathy and emotionality were obtained and correlated with the most significant DTI, VBM and fcMRI findings. We found three regions of convergent structural and functional differences between HFA participants and controls. The right temporo-parietal junction area and the left frontal lobe showed decreased fractional anisotropy (FA values along with decreased functional connectivity and a trend towards decreased gray matter volume. The bilateral superior temporal gyrus displayed significantly decreased functional connectivity that was accompanied by the strongest trend of gray matter volume decrease in the temporal lobe of HFA individuals. FA decrease in the right temporo-parietal region was correlated with psychological measurements of decreased emotionality. In conclusion, our results indicate common sites of structural and functional alterations in higher order association cortex areas and may therefore provide multimodal imaging support to the long-standing hypothesis of autism as a disorder of impaired higher-order multisensory integration.

  7. Giant lobelias exemplify convergent evolution.

    Science.gov (United States)

    Givnish, Thomas J

    2010-01-14

    Giant lobeliads on tropical mountains in East Africa and Hawaii have highly unusual, giant-rosette growth forms that appear to be convergent on each other and on those of several independently evolved groups of Asteraceae and other families. A recent phylogenetic analysis by Antonelli, based on sequencing the widest selection of lobeliads to date, raises doubts about this paradigmatic example of convergent evolution. Here I address the kinds of evidence needed to test for convergent evolution and argue that the analysis by Antonelli fails on four points. Antonelli's analysis makes several important contributions to our understanding of lobeliad evolution and geographic spread, but his claim regarding convergence appears to be invalid. Giant lobeliads in Hawaii and Africa represent paradigmatic examples of convergent evolution.

  8. Giant lobelias exemplify convergent evolution

    Directory of Open Access Journals (Sweden)

    Givnish Thomas J

    2010-01-01

    Full Text Available Abstract Giant lobeliads on tropical mountains in East Africa and Hawaii have highly unusual, giant-rosette growth forms that appear to be convergent on each other and on those of several independently evolved groups of Asteraceae and other families. A recent phylogenetic analysis by Antonelli, based on sequencing the widest selection of lobeliads to date, raises doubts about this paradigmatic example of convergent evolution. Here I address the kinds of evidence needed to test for convergent evolution and argue that the analysis by Antonelli fails on four points. Antonelli's analysis makes several important contributions to our understanding of lobeliad evolution and geographic spread, but his claim regarding convergence appears to be invalid. Giant lobeliads in Hawaii and Africa represent paradigmatic examples of convergent evolution.

  9. Statistical validation of high-dimensional models of growing networks

    CERN Document Server

    Medo, Matus

    2013-01-01

    The abundance of models of complex networks and the current insufficient validation standards make it difficult to judge which models are strongly supported by data and which are not. We focus here on likelihood maximization methods for models of growing networks with many parameters and compare their performance on artificial and real datasets. While high dimensionality of the parameter space harms the performance of direct likelihood maximization on artificial data, this can be improved by introducing a suitable penalization term. Likelihood maximization on real data shows that the presented approach is able to discriminate among available network models. To make large-scale datasets accessible to this kind of analysis, we propose a subset sampling technique and show that it yields substantial model evidence in a fraction of time necessary for the analysis of the complete data.

  10. Convergence role of transcriptional coactivator p300 and apparent modification on HMCs metabolic memory induced by high glucose

    Directory of Open Access Journals (Sweden)

    Hong SU

    2013-03-01

    Full Text Available Objective  To investigate the protein expression of transcriptional coactivator p300, acetylated histone H3 (Ac-H3 and Ac-H4 in human renal mesangial cell (HMCs as imitative "metabolic memory" in vitro, and explore the potential role of convergence point of p300. Methods  The HMCs were divided into the following groups: ① High glucose metabolic memory model: normal glucose group (NG, 5.5mmol/L D-glucose×2d, high glucose group (HG, 25mmol/L D-glucose×2d, memory groups (M1, M2, M3, 25mmol/L D-glucose×2days + 5.5mmol/L D-glucose×3d, 6d or 9d, persisting normal glucose group (NG, 5.5mmol/L D-glucose×9d. ② Advanced glycation end products memory model: normal glucose group (NG, 5.5mmol/ L D-glucose×2d, NG+AGEs group (AGEs, 5.5mmol/L D-glucose+250µg/ml AGEs×2d; AGEs memory group (AGEs-M, 5.5mmol/L D-glucose + 250µg/ml AGEs×2d + 5.5mmol/L D-glucose×3d; BSA control group (NG+BSA, 5.5mmol/L D-glucose + 250µg/ml BSA×2d. ③ H2O2 was used to simulate oxidative stress memory model: normal glucose group (NG, 5.5mmol/L D-glucose×2d, NG+H2O2 group (H2O2, 5.5mmol/L D-glucose +100µmol/L H2O2×30min; H2O2 memory group [(5.5mmol/ L D-glucose + 100µmol/L H2O2×30min + 5.5mmol/L D-glucose×3d]; normal glucose control group (NG3, 5.5mmol/L D-glucose×3d. ④ Transfection with PKCβ2 memory model: normal glucose group (NG, 5.5mmol/L D-glucose×2d; high glucose group (HG, 25mmol/L D-glucose×2d; memory group (M, 25mmol/L D-glucose×2d + 5.5mmol/L D-glucose×3d; Ad5-null memory group (HN, 25mmol/L D-glucose + Ad5-null×2d + 5.5mmol/L D-glucose×3d; PKCβ2 memory group (PO, 25mmol/L D-glucose + Ad5-PKCβ2×2d + 5.5mmol/L D-glucose×3d; inhibitor of PKCβ2 memory group (PI, 25mmol/L D-glucose×2d + 10µmol/L CGP53353 + 5.5mmol/L D-glucose×3d. The expression of intracellular reactive oxygen species (ROS was detected by fluorescence microscope and fluorescence microplate reader. The expression levels of p300, Ac-H3, Ac-H4 and PKCβ2 proteins were

  11. Fast converging with high accuracy estimates of satellite attitude and orbit based on magnetometer augmented with gyro, star sensor and GPS via extended Kalman filter

    Directory of Open Access Journals (Sweden)

    Tamer Mekky Ahmed Habib

    2011-12-01

    Full Text Available The primary goal of this work is to extend the work done in, Tamer (2009, to provide high accuracy satellite attitude and orbit estimates needed for imaging purposes and also before execution of spacecraft orbital maneuvers for the next Egyptian scientific satellite. The problem of coarse satellite attitude and orbit estimation based on magnetometer measurements has been treated in the literature. The current research expands the field of application from coarse and slow converging estimates to accurate and fast converging attitude and orbit estimates within 0.1°, and 10 m for attitude angles and spacecraft location respectively (1-σ. The magnetometer is used for both spacecraft attitude and orbit estimation, aided with gyro to provide angular velocity measurements, star sensor to provide attitude quaternion, and GPS receiver to provide spacecraft location. The spacecraft under consideration is subject to solar radiation pressure forces and moments, aerodynamics forces and moments, earth’s oblateness till the fourth order (i.e. J4, gravity gradient moments, and residual magnetic dipole moments. The estimation algorithm developed is powerful enough to converge quickly (actually within 10 s despite very large initial estimation errors with sufficiently high accuracy estimates.

  12. Excellence of numerical differentiation method in calculating the coefficients of high temperature series expansion of the free energy and convergence problem of the expansion

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, S., E-mail: chixiayzsq@yahoo.com [School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China); Solana, J. R. [Departamento de Física Aplicada, Universidad de Cantabria, 39005 Santander (Spain)

    2014-12-28

    In this paper, it is shown that the numerical differentiation method in performing the coupling parameter series expansion [S. Zhou, J. Chem. Phys. 125, 144518 (2006); AIP Adv. 1, 040703 (2011)] excels at calculating the coefficients a{sub i} of hard sphere high temperature series expansion (HS-HTSE) of the free energy. Both canonical ensemble and isothermal-isobaric ensemble Monte Carlo simulations for fluid interacting through a hard sphere attractive Yukawa (HSAY) potential with extremely short ranges and at very low temperatures are performed, and the resulting two sets of data of thermodynamic properties are in excellent agreement with each other, and well qualified to be used for assessing convergence of the HS-HTSE for the HSAY fluid. Results of valuation are that (i) by referring to the results of a hard sphere square well fluid [S. Zhou, J. Chem. Phys. 139, 124111 (2013)], it is found that existence of partial sum limit of the high temperature series expansion series and consistency between the limit value and the true solution depend on both the potential shapes and temperatures considered. (ii) For the extremely short range HSAY potential, the HS-HTSE coefficients a{sub i} falls rapidly with the order i, and the HS-HTSE converges from fourth order; however, it does not converge exactly to the true solution at reduced temperatures lower than 0.5, wherein difference between the partial sum limit of the HS-HTSE series and the simulation result tends to become more evident. Something worth mentioning is that before the convergence order is reached, the preceding truncation is always improved by the succeeding one, and the fourth- and higher-order truncations give the most dependable and qualitatively always correct thermodynamic results for the HSAY fluid even at low reduced temperatures to 0.25.

  13. High inter-rater reliability, agreement, and convergent validity of Constant score in patients with clavicle fractures

    DEFF Research Database (Denmark)

    Ban, Ilija; Troelsen, Anders; Kristensen, Morten Tange

    2016-01-01

    standardized CS assessment at a mean of 6.8 weeks (SD, 1.0 weeks) after injury. Reliability and agreement of the CS were determined by 2 raters. The interclass correlation coefficient (ICC2,1), standard error of measurement, minimal detectable change, Cronbach α coefficient, and Pearson correlation coefficient....... The secondary aim was to estimate the correlation between the CS and the Disabilities of the Arm, Shoulder and Hand score and the internal consistency of the 2 scores. METHODS: On the basis of sample sizing, 36 patients (31 male and 5 female patients; mean age, 41.3 years) with clavicle fractures underwent...... were estimated. RESULTS: Inter-rater reliability of the total CS was excellent (interclass correlation coefficient, 0.94; 95% confidence interval, 0.88-0.97), with no systematic difference between the 2 raters (P = .75). The standard error of measurement (measurement error at the group level) was 4...

  14. Validation of body composition models for high school wrestlers.

    Science.gov (United States)

    Williford, H N; Smith, J F; Mansfield, E R; Conerly, M D; Bishop, P A

    1986-04-01

    This study investigates the utility of two equations for predicting minimum wrestling weight and three equations for predicting body density for the population of high school wrestlers. A sample of 54 wrestlers was assessed for body density by underwater weighing, residual volume by helium dilution, and selected anthropometric measures. The differences between observed and predicted responses were analyzed for the five models. Four statistical tests were used to validate the equations, including tests for the mean of differences, proportion of positive differences, equality of standard errors from regression, and equivalence of regression coefficients between original and second sample data. The Michael and Katch equation and two Forsyth and Sinning equations (FS1 and FS21) for body density did not predict as well as expected. The Michael and Katch equation tends to overpredict body density while FS1 underpredicts. The FS2 equation, consisting of a constant adjustment to FS1, predicts well near the mean but not at the ends of the sample range. The two Tcheng and Tipton equations produce estimates which slightly but consistently overpredict minimum wrestling weight, the long form equation by 2.5 pounds and the short form by 3.8 pounds. As a result the proportion of positive differences is less than would be expected. But based on the tests for the standard errors and regression coefficients, the evidence does not uniformly reject these two equations.

  15. Strong path convergence from Loewner driving convergence

    CERN Document Server

    Sheffield, Scott

    2010-01-01

    We show that, under mild assumptions on the limiting curve, a sequence of simple chordal planar curves converges uniformly whenever certain Loewner driving functions converge. We extend this result to random curves. The random version applies in particular to random lattice paths that have chordal SLE as a scaling limit, with kappa less than 8 (non-space-filling). Existing SLE convergence proofs often begin by showing that the Loewner driving functions of these paths (viewed from infinity) converge to Brownian motion. Unfortunately, this is not sufficient, and additional arguments are required to complete the proofs. We show that driving function convergence is sufficient if it can be established for both parametrization directions and a generic target.

  16. Alignment validation

    Energy Technology Data Exchange (ETDEWEB)

    ALICE; ATLAS; CMS; LHCb; Golling, Tobias

    2008-09-06

    The four experiments, ALICE, ATLAS, CMS and LHCb are currently under constructionat CERN. They will study the products of proton-proton collisions at the Large Hadron Collider. All experiments are equipped with sophisticated tracking systems, unprecedented in size and complexity. Full exploitation of both the inner detector andthe muon system requires an accurate alignment of all detector elements. Alignmentinformation is deduced from dedicated hardware alignment systems and the reconstruction of charged particles. However, the system is degenerate which means the data is insufficient to constrain all alignment degrees of freedom, so the techniques are prone to converging on wrong geometries. This deficiency necessitates validation and monitoring of the alignment. An exhaustive discussion of means to validate is subject to this document, including examples and plans from all four LHC experiments, as well as other high energy experiments.

  17. Development and psychometric validation of the Brief Intellectual Disability Scale for use in low-health resource, high-burden countries.

    Science.gov (United States)

    Mammen, Priya; Russell, Paul Swamidhas Sudhakar; Nair, Muttathu K C; Russell, Sushila; Kishore, Catherine; Shankar, Satyaraj

    2013-01-01

    To develop and validate a concise, parent-completed Brief Intellectual Disability Scale (BIDS) for children in low-disability resource and high-disability care burden countries. In this prospective cross-sectional study of 124 children recruited from a facility for intellectual disability (ID), the newly developed BIDS as the measure for validation as well as for the gold standard and convergent and divergent validities was administered by independent raters. Tests for diagnostic accuracy, reproducibility, and validity were conducted at the item and scale levels. The BIDS scores of ≥5 (sensitivity [Sn] = 71.43%, specificity [Sp] = 80.95%) and ≥11 (Sn = 4.29%, Sp = 100%), with area under the curve of 0.79, are suggested, respectively, for screening and diagnostic use in Indian populations. The inter-rater reliability (intra-class correlation coefficient [ICC] = 0.96) and test-retest reliability at 4 weeks (ICC = 0.95) for BIDS are strong. Besides the adequate face and content validities, BIDS demonstrates good internal consistency (Cronbach α = 0.80) and item-total correlation. There is moderate convergent validity with Binet-Kamat Test of Intelligence or Gesell's Developmental Schedule (r = -0.66, P = 0.001) as well as with adaptive behavior measure of Vineland Social Maturity Scale (r =-0.52, P = 0.001) and low divergent validity with the subscales of Attention Deficit Disorder with Hyperactivity: Comprehensive Teacher Rating Scale ( r = -0.11, P = 0.7; r = 0.18, P = 0.5; r = 0.13, P = 0.6; r = 0.08, P = 0.7). An exploratory factor analysis demonstrated a three-factor structure, explaining 60% of variance. The BIDS shows promise as a psychometrically adequate, yet brief measure for identifying ID in countries with low disability care resources and high disability-related burden. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Brief report: The Identity Style Inventory (ISI-3) and the Utrecht-Management of Identity Commitments Scale (U-MICS): factor structure, reliability, and convergent validity in French-speaking university students.

    Science.gov (United States)

    Zimmermann, Grégoire; Mahaim, Elodie Biermann; Mantzouranis, Gregory; Genoud, Philippe A; Crocetti, Elisabetta

    2012-04-01

    The purpose of this study was to evaluate the factor structure and the reliability of the French versions of the Identity Style Inventory (ISI-3) and the Utrecht-Management of Identity Commitments Scale (U-MICS) in a sample of college students (N = 457, 18-25 years old). Confirmatory factor analyses confirmed the hypothesized three-factor solution of the ISI-3 identity styles (i.e. informational, normative, and diffuse-avoidant styles), the one-factor solution of the ISI-3 identity commitment, and the three-factor structure of the U-MICS (i.e. commitment, in-depth exploration, and reconsideration of commitment). Additionally, theoretically consistent and meaningful associations among the ISI-3, U-MICS, and Ego Identity Process Questionnaire (EIPQ) confirmed convergent validity. Overall, the results of the present study indicate that the French versions of the ISI-3 and UMICS are useful instruments for assessing identity styles and processes, and provide additional support to the cross-cultural validity of these tools.

  19. Social Skills and Psychological Disorders: Converging and Criterion-Related Validity for YSR and IHSA-Del-Prette in Adolescents at Risk [Habilidades sociales y trastornos psicológicos: validez convergente y de criterio para YSR e IHSA- Del-Prette en Adolescentes en riesgo

    Directory of Open Access Journals (Sweden)

    Zilda Aparecida Pereira Del Prette

    2012-07-01

    Full Text Available This study evaluated indexes of converging and criterion-related validi- ty for the Social Skills Inventory for Adolescents (IHSA-Del-Prette and the Youth Self-Report (YSR in two samples: one referring to clinical ser- vice (CLIN, with 28 adolescents (64.3% boys, 11 through 17 years old (M = 13.75; SD = 1.74, and the other referring to a psycho-educational program (PME = 46.2%, mainly composed of boys (91.7% aged 13 through 17 (M = 15.33; SD = 1.47. Both samples completed the two inventories. Results showed a high incidence of psychological disorders in both samples (between 4% and 79% in the borderline or clinical range on YSR scales and accentuated deficits in the general and subscale scores of IHSA-Del-Prette, especially on the frequency scale (25% to 58%. The correlations between the instruments in the two groups supported criterion-related and converging validity. Some issues concerning the differences between the samples and about the construct of social competence, underlying these inventories, are discussed.

  20. There is poverty convergence

    OpenAIRE

    Crespo Cuaresma, Jesus; Klasen, Stephan; Wacker, Konstantin M.

    2016-01-01

    Martin Ravallion ("Why Don't We See Poverty Convergence?" American Economic Review, 102(1): 504-23; 2012) presents evidence against the existence of convergence in global poverty rates despite convergence in household mean income levels and the close linkage between income growth and poverty reduction. We show that this finding is driven by a specification that demands more than simple convergence in poverty headcount rates and assumes a growth elasticity of poverty reduction, which is well-k...

  1. Convergence S-compactifications

    Directory of Open Access Journals (Sweden)

    Bernd Losert

    2014-07-01

    Full Text Available Properties of continuous actions on convergence spaces are investigated. The primary focus is the characterization as to when a continuous action on a convergence space can be continuously extended to an action on a compactification of the convergence space. The largest and smallest such compactifications are studied.

  2. Norm-Resolvent Convergence of One-Dimensional High-Contrast Periodic Problems to a Kronig-Penney Dipole-Type Model

    Science.gov (United States)

    Cherednichenko, Kirill D.; Kiselev, Alexander V.

    2016-07-01

    We prove operator-norm resolvent convergence estimates for one-dimensional periodic differential operators with rapidly oscillating coefficients in the non-uniformly elliptic high-contrast setting, which has been out of reach of the existing homogenisation techniques. Our asymptotic analysis is based on a special representation of the resolvent of the operator in terms of the M-matrix of an associated boundary triple ("Krein resolvent formula"). The resulting asymptotic behaviour is shown to be described, up to a unitary transformation, by a non-standard version of the Kronig-Penney model on R.

  3. Systematic approach to verification and validation: High explosive burn models

    Energy Technology Data Exchange (ETDEWEB)

    Menikoff, Ralph [Los Alamos National Laboratory; Scovel, Christina A. [Los Alamos National Laboratory

    2012-04-16

    Most material models used in numerical simulations are based on heuristics and empirically calibrated to experimental data. For a specific model, key questions are determining its domain of applicability and assessing its relative merits compared to other models. Answering these questions should be a part of model verification and validation (V and V). Here, we focus on V and V of high explosive models. Typically, model developers implemented their model in their own hydro code and use different sets of experiments to calibrate model parameters. Rarely can one find in the literature simulation results for different models of the same experiment. Consequently, it is difficult to assess objectively the relative merits of different models. This situation results in part from the fact that experimental data is scattered through the literature (articles in journals and conference proceedings) and that the printed literature does not allow the reader to obtain data from a figure in electronic form needed to make detailed comparisons among experiments and simulations. In addition, it is very time consuming to set up and run simulations to compare different models over sufficiently many experiments to cover the range of phenomena of interest. The first difficulty could be overcome if the research community were to support an online web based database. The second difficulty can be greatly reduced by automating procedures to set up and run simulations of similar types of experiments. Moreover, automated testing would be greatly facilitated if the data files obtained from a database were in a standard format that contained key experimental parameters as meta-data in a header to the data file. To illustrate our approach to V and V, we have developed a high explosive database (HED) at LANL. It now contains a large number of shock initiation experiments. Utilizing the header information in a data file from HED, we have written scripts to generate an input file for a hydro code

  4. Convergent Validity of a Wearable Sensor System for Measuring Sub-Task Performance during the Timed Up-and-Go Test.

    Science.gov (United States)

    Beyea, James; McGibbon, Chris A; Sexton, Andrew; Noble, Jeremy; O'Connell, Colleen

    2017-04-23

    The timed-up-and-go test (TUG) is one of the most commonly used tests of physical function in clinical practice and for research outcomes. Inertial sensors have been used to parse the TUG test into its composite phases (rising, walking, turning, etc.), but have not validated this approach against an optoelectronic gold-standard, and to our knowledge no studies have published the minimal detectable change of these measurements. Eleven adults performed the TUG three times each under normal and slow walking conditions, and 3 m and 5 m walking distances, in a 12-camera motion analysis laboratory. An inertial measurement unit (IMU) with tri-axial accelerometers and gyroscopes was worn on the upper-torso. Motion analysis marker data and IMU signals were analyzed separately to identify the six main TUG phases: sit-to-stand, 1st walk, 1st turn, 2nd walk, 2nd turn, and stand-to-sit, and the absolute agreement between two systems analyzed using intra-class correlation (ICC, model 2) analysis. The minimal detectable change (MDC) within subjects was also calculated for each TUG phase. The overall difference between TUG sub-tasks determined using 3D motion capture data and the IMU sensor data was time and walk times (ICC > 0.90), but less for chair activity (ICC range 0.5-0.9) and typically poor for the turn time (ICC time ranged between 2-4 s or 12-22% of the TUG time measurement. MDC of the sub-task times were higher proportionally, being 20-60% of the sub-task duration. We conclude that a commercial IMU can be used for quantifying the TUG phases with accuracy sufficient for clinical applications; however, the MDC when using inertial sensors is not necessarily improved over less sophisticated measurement tools.

  5. Validation of High-Fidelity CFD Simulations for Rocket Injector Design

    Science.gov (United States)

    Tucker, P. Kevin; Menon, Suresh; Merkle, Charles L.; Oefelein, Joseph C.; Yang, Vigor

    2008-01-01

    Computational fluid dynamics (CFD) has the potential to improve the historical rocket injector design process by evaluating the sensitivity of performance and injector-driven thermal environments to the details of the injector geometry and key operational parameters. Methodical verification and validation efforts on a range of coaxial injector elements have shown the current production CFD capability must be improved in order to quantitatively impact the injector design process. This paper documents the status of a focused effort to compare and understand the predictive capabilities and computational requirements of a range of CFD methodologies on a set of single element injector model problems. The steady Reynolds-Average Navier-Stokes (RANS), unsteady Reynolds-Average Navier-Stokes (URANS) and three different approaches using the Large Eddy Simulation (LES) technique were used to simulate the initial model problem, a single element coaxial injector using gaseous oxygen and gaseous hydrogen propellants. While one high-fidelity LES result matches the experimental combustion chamber wall heat flux very well, there is no monotonic convergence to the data with increasing computational tool fidelity. Systematic evaluation of key flow field regions such as the flame zone, the head end recirculation zone and the downstream near wall zone has shed significant, though as of yet incomplete, light on the complex, underlying causes for the performance level of each technique. 1 Aerospace Engineer and Combustion CFD Team Leader, MS ER42, NASA MSFC, AL 35812, Senior Member, AIAA. 2 Professor and Director, Computational Combustion Laboratory, School of Aerospace Engineering, 270 Ferst Dr., Atlanta, GA 30332, Associate Fellow, AIAA. 3 Reilly Professor of Engineering, School of Mechanical Engineering, 585 Purdue Mall, West Lafayette, IN 47907, Fellow, AIAA. 4 Principal Member of Technical Staff, Combustion Research Facility, 7011 East Avenue, MS9051, Livermore, CA 94550, Associate

  6. Convergence of electromagnetic coilgun design code and its experimental validation%电磁线圈炮计算程序的收敛性与实验验证

    Institute of Scientific and Technical Information of China (English)

    何勇; 高贵山; 宋盛义; 关永超; 程诚; 李业勋; 仇旭

    2014-01-01

    根据电磁线圈炮中推力线圈与电枢之间的感应耦合方程和电枢动态响应方程,考虑发射过程中推力线圈和电枢的欧姆加热,开发了电磁线圈炮的计算程序,给出了程序的算法和流程。分析了程序的收敛性,认为最大时间步长和电枢最大网格均依赖于驱动脉冲波形的上升时间。通过模拟结果与单级线圈炮实验测量结果的比较,验证了程序的有效性。模拟的线圈电流波形与实验波形吻合较好,模拟的出口速度比测量速度大约6.5%。程序收敛性和有效性的验证表明该程序可用于电磁线圈炮系统的初步设计。%A coilgun design code is programmed according to the formulas describing the inductive coupling between the thrust coils and the armature,the dynamic response of the armature,and the ohmic heating in the thrust coils and armature.The algorithms determining the operation status of the driven pulse forming network are presented.The convergence of the code is an-alyzed.The maximum time-step and mesh size of the armature are dependent on the rise time of the driven pulse current.The code is validated by comparing the simulated results with the experimental ones.The calculated coil current wave is in agreement with the experimental results.However,the calculated velocity is higher than the measured one about 6.5%.The convergence and validation of the code indicate that it can be used for the primary design for a coilgun system.

  7. Order Handling in Convergent Environments

    CERN Document Server

    Vrtanoski, Jordan

    2012-01-01

    The rapid development of IT&T technology had big impact on the traditional telecommunications market, transforming it from monopolistic market to highly competitive high-tech market where new services are required to be created frequently. This paper aims to describe a design approach that puts order management process (as part of enterprise application integration) in function of rapid service creation. In the text we will present a framework for collaborative order handling supporting convergent services. The design splits the order handling processes in convergent environments in three business process groups: order capture, order management and order fulfillment. The paper establishes abstract framework for order handling and provides design guidelines for transaction handling implementation based on the checkpoint and inverse command strategy. The proposed design approach is based in a convergent telecommunication environment. Same principles are applicable in solving problems of collaboration in fun...

  8. Numerical simulation of converging shock waves

    Science.gov (United States)

    Yee, Seokjune; Abe, Kanji

    We can achieve the high pressure and high temperature state of gas if the shock wave converges stably. In order to check the stability of the converging shock wave, we introduce two kinds of perturbed initial conditions. The Euler equations of conservation form are integrated by using explicit Non-Muscl TVD finite difference scheme.

  9. A Methodology for Validation of High Resolution Combat Models

    Science.gov (United States)

    1988-06-01

    Additionally, as sensors on a target register receipt of a laser pulse, the B unit will transmit the near miss , hit, or kill status of the shot, and the...Laser Illumination Event sent by target. This event is one of three differend kinds of codes, for HIT, NEAR MISS , and KILL. Live Fire There are four...Once a valid arrangement of bits is formed corresponding to a code for a particular weapon, a decision is made to determine "hit" or " near miss ". To

  10. Converged Registries Solution (CRS)

    Data.gov (United States)

    Department of Veterans Affairs — The Converged Registries platform is a hardware and software architecture designed to host individual patient registries and eliminate duplicative development effort...

  11. Vadose zone flow convergence test suite

    Energy Technology Data Exchange (ETDEWEB)

    Butcher, B. T. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-06-05

    Performance Assessment (PA) simulations for engineered disposal systems at the Savannah River Site involve highly contrasting materials and moisture conditions at and near saturation. These conditions cause severe convergence difficulties that typically result in unacceptable convergence or long simulation times or excessive analyst effort. Adequate convergence is usually achieved in a trial-anderror manner by applying under-relaxation to the Saturation or Pressure variable, in a series of everdecreasing RELAxation values. SRNL would like a more efficient scheme implemented inside PORFLOW to achieve flow convergence in a more reliable and efficient manner. To this end, a suite of test problems that illustrate these convergence problems is provided to facilitate diagnosis and development of an improved convergence strategy. The attached files are being transmitted to you describing the test problem and proposed resolution.

  12. Explaining convergence of oecd welfare states

    DEFF Research Database (Denmark)

    Schmitt, C.; Starke, Peter

    2011-01-01

    Existing studies have found only limited empirical evidence of welfare state convergence. Moreover, although there are good theoretical reasons both for and against welfare state convergence, there are virtually no studies that have explicitly tested the assumed effects. We argue that the concept....... First, we show that there is very strong evidence of convergence across all categories of social expenditure when conditional factors are taken into account. Second, we demonstrate that the speed of convergence is highly driven by globalization and European Union membership and shaped by existing...... welfare state structures. © The Author(s) 2011....

  13. Convergent validation study of the Contemplation Ladder for application via telephone in tobacco users Estudo da validação convergente da Escala de Contemplação Ladder aplicada por telefone em tabagistas

    Directory of Open Access Journals (Sweden)

    Mauro Barbosa Terra

    2009-01-01

    Full Text Available OBJECTIVE: This work was designed to validate the Portuguese version of the Contemplation Ladder, whose purpose is to assess the motivational phase to quit smoking among tobacco users using a telephone service. METHOD: A cross-sectional study was conducted in a nationwide drug use information hotline. In order to assess the convergent validation, the correlation between the Contemplation Ladder and the URICA Scale was calculated, which was previously validated. RESULTS: The study included 271 tobacco users. Statistically significant correlations were found between the Contemplation Ladder scores and the scores of the URICA precontemplation (r=-0.16; pOBJETIVO: Este estudo teve como objetivo validar a versão em português da Escala de Contemplação Ladder, que visa verificar o estágio motivacional para parar de fumar em tabagistas, em um serviço de atendimento telefônico. MÉTODO: Um estudo transversal foi conduzido em um serviço de âmbito nacional de informação sobre uso de drogas por telefone. Para avaliação da validação convergente foi calculada a correlação entre a Escala de Contemplação Ladder e a Escala URICA, a qual já foi validada anteriormente. RESULTADOS: O estudo incluiu 271 tabagistas. Foram encontradas correlações estatisticamente significativas entre os escores da Escala de Contemplação Ladder e os escores das subescalas de pré-contemplação (r=-0,16; p<0,01, ação (r=0,15; p<0,01 e manutenção (r=0,18; p<0,01 da URICA. A correlação entre o escore composto da Escala URICA e a Escala de Contemplação Ladder também foi significativa (r=0,31; p<0,01. CONCLUSÃO: Os resultados do nosso estudo sugerem que a Escala de Contemplação Ladder pode ser uma alternativa para a Escala URICA (cuja aplicação dura no máximo 20 minutos, sem se impor uma carga maior de perguntas ao entrevistado. O estudo mostrou evidências de validade convergente da Escala de Contemplação Ladder, quando aplicada por telefone, em

  14. An experimental investigation of thrust vectoring two-dimensional convergent-divergent nozzles installed in a twin-engine fighter model at high angles of attack

    Science.gov (United States)

    Capone, Francis J.; Mason, Mary L.; Leavitt, Laurence D.

    1990-01-01

    An investigation was conducted in the Langley 16-Foot Transonic Tunnel to determine thrust vectoring capability of subscale 2-D convergent-divergent exhaust nozzles installed on a twin engine general research fighter model. Pitch thrust vectoring was accomplished by downward rotation of nozzle upper and lower flaps. The effects of nozzle sidewall cutback were studied for both unvectored and pitch vectored nozzles. A single cutback sidewall was employed for yaw thrust vectoring. This investigation was conducted at Mach numbers ranging from 0 to 1.20 and at angles of attack from -2 to 35 deg. High pressure air was used to simulate jet exhaust and provide values of nozzle pressure ratio up to 9.

  15. [Cultural scale adaptation and validation of the Spanish version of the BRCA Self-Concept Scale in women carriers at high risk for hereditary breast and ovarian cancer].

    Science.gov (United States)

    Castejón, Vanessa; Rovira, Tatiana; Sumalla, Enric C; Darder, Esther; Iglesias, Silvia; Ochoa, Cristian; Blanco, Ignacio

    2016-02-19

    Having an inherited predisposition to cancer may have a psychological impact, and one goal of genetic counseling is to promote psychological adjustment to the new situation. Thus, in the genetic context, validated measures of adjustment are required. Given that self-concept is a good indicator of adjustment to the disease or to the risk for it, and a relevant variable in oncology, the goal of the study is to culturally adapt and validate the BRCA Self-Concept Scale. One hundred and sixty-five BRCA carriers' women answered to the questionnaire, previously adapted through a process of forward/back-translation, and to the Cancer Worry Scale (CWS) as a measure of convergent validity. Theoretical structure of BRCA Self-Concept Scale was assessed by expert judges, and submitted to a confirmatory factor analysis (CFA). Cronbach's α was calculated for each subscale (Stigma, Vulnerability and Control), and correlations with CWS were performed. Expert judges' structure and CFA do not support the original structure of the questionnaire. The respecificity model (with items 10 and 13 loading on Vulnerability factor) show a better fit: comparative fit index 0.973; Tucker-Lewis index 0.968; root mean square error of approximation 0.067. The Cronbach's α is 0.83 for Stigma, 0.84 for Vulnerability, and 0.61 for Control. Evidence of convergent validity with CWS has been obtained (Spearman's rho 0.631 for Stigma, 0.683 for Vulnerability, and -0.363 for Control; P<.001). Results support the validity of the modified Spanish BRCA Self-Concept Scale, which is a potentially useful measure for the study of psychological adjustment to high risk for hereditary breast and ovarian cancer. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

  16. Convergence of DFP algorithm

    Institute of Scientific and Technical Information of China (English)

    袁亚湘

    1995-01-01

    The DFP method is one of the most famous numerical algorithms for unconstrained optimization. For uniformly convex objective functions convergence properties of the DFP method are studied. Several conditions that can ensure the global convergence of the DFP method are given.

  17. Combined Heat Transfer in High-Porosity High-Temperature Fibrous Insulations: Theory and Experimental Validation

    Science.gov (United States)

    Daryabeigi, Kamran; Cunnington, George R.; Miller, Steve D.; Knutson, Jeffry R.

    2010-01-01

    Combined radiation and conduction heat transfer through various high-temperature, high-porosity, unbonded (loose) fibrous insulations was modeled based on first principles. The diffusion approximation was used for modeling the radiation component of heat transfer in the optically thick insulations. The relevant parameters needed for the heat transfer model were derived from experimental data. Semi-empirical formulations were used to model the solid conduction contribution of heat transfer in fibrous insulations with the relevant parameters inferred from thermal conductivity measurements at cryogenic temperatures in a vacuum. The specific extinction coefficient for radiation heat transfer was obtained from high-temperature steady-state thermal measurements with large temperature gradients maintained across the sample thickness in a vacuum. Standard gas conduction modeling was used in the heat transfer formulation. This heat transfer modeling methodology was applied to silica, two types of alumina, and a zirconia-based fibrous insulation, and to a variation of opacified fibrous insulation (OFI). OFI is a class of insulations manufactured by embedding efficient ceramic opacifiers in various unbonded fibrous insulations to significantly attenuate the radiation component of heat transfer. The heat transfer modeling methodology was validated by comparison with more rigorous analytical solutions and with standard thermal conductivity measurements. The validated heat transfer model is applicable to various densities of these high-porosity insulations as long as the fiber properties are the same (index of refraction, size distribution, orientation, and length). Furthermore, the heat transfer data for these insulations can be obtained at any static pressure in any working gas environment without the need to perform tests in various gases at various pressures.

  18. The EU's Convergence Dilemma

    Directory of Open Access Journals (Sweden)

    Notermans Ton

    2015-02-01

    Full Text Available As economic stagnation continues to mark the EU in the fifth year of the euro zone crisis, political support for integration is waning. The European Parliament elections of 2014 returned a hitherto unparalleled number of Eurosceptic MEPs, with EU-critical parties becoming the largest ones in several Member States. Much of this Euroscepticism is driven by economic polarisation between core and peripheral countries. While an increasing number of voters in the northwestern creditor countries resent having to foot the bill for what they consider economic mismanagement in the periphery, voters in peripheral countries increasingly rebel against what they deem to be an economically catastrophic Diktat from Germany and its allies. Continued political support for European integration will hinge on successful income convergence in the EU but the current dilemma is that such policies might not be politically feasible. Periods of rapid convergence would seem to suggest that success depends on two main policy strategies. First, a monetary policy that promotes credit for productive purposes, leaves inflation control to other instruments, and employs selective credit rationing to prevent asset booms. Second, a vertical industrial policy prioritising selected industrial sectors. The first policy conflicts with the present framework of euro zone monetary policy, but that framework was only installed in the first place because many peripheral countries were desperately in search of an external constraint on domestic distributional conflict. Industrial policies, in turn, require a sufficient degree of state autonomy from business elites in order to be effective, but it is highly questionable whether most states in the EU possess such autonomy. Though there are, as yet hesitant, signs of a reorientation of both monetary and cohesion policy in the EU, the question of the institutional and political preconditions for their successful implementation has been largely

  19. Secure versus fragile high self-esteem as a predictor of verbal defensiveness: converging findings across three different markers.

    Science.gov (United States)

    Kernis, Michael H; Lakey, Chad E; Heppner, Whitney L

    2008-06-01

    Why is it that many individuals verbally rationalize and distort self-esteem threatening information? We examined whether such verbal defensiveness (Feldman Barrett, Williams, & Fong, 2002) differs as a function of whether individuals' high self-esteem is secure or fragile. Our findings indicated that individuals whose self-esteem was stable, not contingent, or congruent with high implicit self-esteem exhibited especially low amounts of verbal defensiveness. In contrast, verbal defensiveness was considerably higher when individuals' high self-esteem was unstable, contingent, or paired with discrepant low implicit self-esteem. Discussion centers on why the possession of well-anchored and secure high self-esteem obviates defensiveness directed toward enhancing, maintaining, or bolstering feelings of self-worth.

  20. Morphological and molecular convergences in mammalian phylogenetics.

    Science.gov (United States)

    Zou, Zhengting; Zhang, Jianzhi

    2016-09-02

    Phylogenetic trees reconstructed from molecular sequences are often considered more reliable than those reconstructed from morphological characters, in part because convergent evolution, which confounds phylogenetic reconstruction, is believed to be rarer for molecular sequences than for morphologies. However, neither the validity of this belief nor its underlying cause is known. Here comparing thousands of characters of each type that have been used for inferring the phylogeny of mammals, we find that on average morphological characters indeed experience much more convergences than amino acid sites, but this disparity is explained by fewer states per character rather than an intrinsically higher susceptibility to convergence for morphologies than sequences. We show by computer simulation and actual data analysis that a simple method for identifying and removing convergence-prone characters improves phylogenetic accuracy, potentially enabling, when necessary, the inclusion of morphologies and hence fossils for reliable tree inference.

  1. Critical validity assessment of theoretical models: charge-exchange at intermediate and high energies

    Science.gov (United States)

    Belkić, Dževad

    1999-06-01

    Exact comprehensive computations are carried out by means of four leading second-order approximations yielding differential cross sections dQ/ dΩ for the basic charge exchange process H ++H(1s)→H(1s)+H + at intermediate and high energies. The obtained extensive set of results is thoroughly tested against all the existing experimental data with the purpose of critically assessing the validity of the boundary corrected second-Born (CB2), continuum-distorted wave (CDW), impulse approximation (IA) and the reformulated impulse approximation (RIA). The conclusion which emerges from this comparative study clearly indicates that the RIA agrees most favorably with the measurements available over a large energy range 25 keV-5 MeV. Such a finding reaffirms the few-particle quantum scattering theory which imposes several strict conditions on adequate second-order methods. These requirements satisfied by the RIA are: (i) normalisations of all the scattering wave functions, (ii) correct boundary conditions in both entrance and exit channels, (iii) introduction of a mathematically justified two-center continuum state for the sum of an attractive and a repulsive Coulomb potential with the same interaction strength, (iv) inclusion of the multiple scattering effects neglected in the IA, (v) a proper description of the Thomas double scattering in good agreement with the experiments and without any unobserved peak splittings. Nevertheless, the performed comparative analysis of the above four approximations indicates that none of the methods is free from some basic shortcomings. Despite its success, the RIA remains essentially a high-energy model like the other three methods under study. More importantly, their perturbative character leaves virtually no room for further systematic improvements, since the neglected higher-order terms are prohibitively tedious for practical purposes and have never been computed exactly. To bridge this gap, we presently introduce the variational Pad

  2. Convergence of Fuzzy Set Sequences

    Institute of Scientific and Technical Information of China (English)

    FENG Yu-hu

    2002-01-01

    There are more than one mode of convergence with respect to the fuzzy set sequences. In this paper,common six modes of convergence and their relationships are discussed. These six modes are convergence in uniform metric D, convergence in separable metric Dp or D*p, 1 ≤ p <∞, convergence in level set, strong convergence in level set and weak convergence. Suitable counterexamples are given. The necessary and sufficient conditions of convergence in uniform metric D are described. Some comme nts on the convergence of LRfuzzy number sequences are represented.

  3. Spacecraft Power Beaming Using High-Energy Lasers, Experimental Validation

    Science.gov (United States)

    Michael, Sherif

    2008-04-01

    The lifetime of many spacecrafts are often limited by degradation of their electrical power subsystem, e.g. radiation-damaged solar arrays or failed batteries. Being able to beam power from terrestrial sites using high energy lasers, could alleviate this limitation, extending the lifetime of billions of dollars of satellite assets, as well as providing additional energy for electric propulsion that can be used for stationkeeping and orbital changes. In addition, extensive research at the Naval Postgraduate School (NPS) has shown the potential for annealing damaged solar cells using lasers. This paper describes that research and a proposed experiment to demonstrate the relevant concepts of high energy laser power beaming to an NPS-built and operated satellite. Preliminary results of ground experiment of laser illuminations of some of the solar panels of one of the spacecrafts are also presented.

  4. Measuring Long-Distance Romantic Relationships: A Validity Study

    Science.gov (United States)

    Pistole, M. Carole; Roberts, Amber

    2011-01-01

    This study investigated aspects of construct validity for the scores of a new long-distance romantic relationship measure. A single-factor structure of the long-distance romantic relationship index emerged, with convergent and discriminant evidence of external validity, high internal consistency reliability, and applied utility of the scores.…

  5. ARTIFICIAL IMMUNE ALGORITHM OF MULTICELLULAR GROUP AND ITS CONVERGENCE

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Objective To find out more extrema simultaneously including global optimum and multiple local optima existed in multi-modal functions. Methods Germinal center is the generator and selector of high-affinity B cells, a multicellular group's artificial immune algorithm was proposed based on the germinal center reaction mechanism of natural immune systems. Main steps of the algorithm were given, including hyper-mutation, selection, memory, similarity suppression and recruitment of B cells and the convergence of it was proved. Results The algorithm has been tested to optimize various multi-modal functions, and the simulation results show that the artificial immune algorithm proposed here can find multiple extremum of these functions with lower computational cost. Conclusion The algorithm is valid and can converge on the satisfactory solution set D with probability 1 and approach to global solution and many local optimal solutions existed.

  6. An Experimentally Validated SOA Model for High-Bit Rate System Applications

    Institute of Scientific and Technical Information of China (English)

    Hasan I. Saleheen

    2003-01-01

    A comprehensive model of the Semiconductor Optical Amplifier with experimental validation result is presented. This model accounts for various physical behavior of the device which is necessary for high bit-rate system application.

  7. Turbulent Scalar Transport Model Validation for High Speed Propulsive Flows Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This effort entails the validation of a RANS turbulent scalar transport model (SFM) for high speed propulsive flows, using new experimental data sets and...

  8. Getting a head in hard soils: Convergent skull evolution and divergent allometric patterns explain shape variation in a highly diverse genus of pocket gophers (Thomomys).

    Science.gov (United States)

    Marcy, Ariel E; Hadly, Elizabeth A; Sherratt, Emma; Garland, Kathleen; Weisbecker, Vera

    2016-10-10

    High morphological diversity can occur in closely related animals when selection favors morphologies that are subject to intrinsic biological constraints. A good example is subterranean rodents of the genus Thomomys, one of the most taxonomically and morphologically diverse mammalian genera. Highly procumbent, tooth-digging rodent skull shapes are often geometric consequences of increased body size. Indeed, larger-bodied Thomomys species tend to inhabit harder soils. We used geometric morphometric analyses to investigate the interplay between soil hardness (the main extrinsic selection pressure on fossorial mammals) and allometry (i.e. shape change due to size change; generally considered the main intrinsic factor) on crania and humeri in this fast-evolving mammalian clade. Larger Thomomys species/subspecies tend to have more procumbent cranial shapes with some exceptions, including a small-bodied species inhabiting hard soils. Counter to earlier suggestions, cranial shape within Thomomys does not follow a genus-wide allometric pattern as even regional subpopulations differ in allometric slopes. In contrast, humeral shape varies less with body size and with soil hardness. Soft-soil taxa have larger humeral muscle attachment sites but retain an orthodont (non-procumbent) cranial morphology. In intermediate soils, two pairs of sister taxa diverge through differential modifications on either the humerus or the cranium. In the hardest soils, both humeral and cranial morphology are derived through large muscle attachment sites and a high degree of procumbency. Our results show that conflict between morphological function and intrinsic allometric patterning can quickly and differentially alter the rodent skeleton, especially the skull. In addition, we found a new case of convergent evolution of incisor procumbency among large-, medium-, and small-sized species inhabiting hard soils. This occurs through different combinations of allometric and non-allometric changes

  9. Fixed mobile convergence handbook

    CERN Document Server

    Ahson, Syed A

    2010-01-01

    From basic concepts to future directions, this handbook provides technical information on all aspects of fixed-mobile convergence (FMC). The book examines such topics as integrated management architecture, business trends and strategic implications for service providers, personal area networks, mobile controlled handover methods, SIP-based session mobility, and supervisory and notification aggregator service. Case studies are used to illustrate technical and systematic implementation of unified and rationalized internet access by fixed-mobile network convergence. The text examines the technolo

  10. Subsequential Convergence Conditions

    Directory of Open Access Journals (Sweden)

    Dik Mehmet

    2007-01-01

    Full Text Available Let be a sequence of real numbers and let be any regular limitable method. We prove that, under some assumptions, if a sequence or its generator sequence generated regularly by a sequence in a class of sequences is a subsequential convergence condition for , then for any integer , the repeated arithmetic means of , , generated regularly by a sequence in the class , is also a subsequential convergence condition for .

  11. IT-BT convergence technology

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-12-15

    This book explains IT-BT convergence technology as the future technology, which includes a prolog, easy IT-BT convergence technology that has infinite potentials for new value, policy of IT-BT convergence technology showing the potential of smart Korea, IT-BT convergence opening happy future, for the new future of IT powerful nation Korea with IT-BT convergence technology and an epilogue. This book reveals the conception, policy, performance and future of IT-BT convergence technology.

  12. Investigating convergence of the reaction $\\gamma p\\to\\pi^\\pm\\Delta$ with tensor meson $a_2$ exchange at high energy

    CERN Document Server

    Yu, Byung-Geel

    2016-01-01

    A Regge approach to the reaction processes $\\gamma p\\to\\pi^-\\Delta^{++}$ and $\\gamma p\\to\\pi^+\\Delta^0$ is presented for the description of existing data up to $E_\\gamma= 16$ GeV. The model consists of the $t$-channel $\\pi+\\rho+a_2$ exchanges which are reggeized from the relevant Born amplitude. Discussion is given on the minimal gauge prescription for the $\\pi$ exchange to render convergent the divergence of the $u$-channel $\\Delta$-pole in the former process. A new Lagrangian is constructed for the $a_2N\\Delta$ coupling in this work and applied to the process for the first time with the coupling constant deduced from the duality plus vector dominance. It is shown that, while the $\\pi$ exchange dominates over the process, the role of the $a_2$ exchange is crucial rather than the $\\rho$ in reproducing the cross sections for total, differential, and photon polarization asymmetry to agree with data at high energy.

  13. Contrast validation test for retrieval method of high frequency ground wave radar

    Institute of Scientific and Technical Information of China (English)

    WANG Hailong; GUO Peifang; HAN Shuzong; XIE Qiang; ZHOU Liangming

    2005-01-01

    In this paper, on the basis of the working principles of high frequency ground wave radar for retrieval of ocean wave and sea wind elements were used to systematically study the data obtained from contrast validation test in Zhoushan sea area of Zhejiang Province on Oct. 2000, to validate the accuracy of OSMAR2000for wave and wind parameters, and to analyze the possible error caused when using OSMAR2000 to retrieve ocean parameters.

  14. Towards a semiquantitative non invasive characterisation of Tyrian purple dye composition: Convergence of UV-Visible reflectance spectroscopy and fast-high temperature-high performance liquid chromatography with photodiode array detection.

    Science.gov (United States)

    Clementi, Catia; Nowik, Witold; Romani, Aldo; Cardon, Dominique; Trojanowicz, Marek; Davantès, Athénaïs; Chaminade, Pierre

    2016-07-05

    In this paper, partial least square (PLS) regression is innovatively applied for a semi-quantitative non invasive study of the most precious dye of Antiquity: Tyrian purple. This original approach for the study of organic dyes in the cultural heritage field, is based on the correlation of spectrophotometric (UV-Visible) and chromatographic (Fast-HT-HPLC-PDA) data from an extensive set of textiles prepared with different snail species according to historical recipes. A cross-validated PLS model, based on the quantity of 6,6'-dibromoindigotin, displays an excellent correlation factor (R(2)Y = 0.987) between values determined by chromatography and those predicted from reflectance spectra. This indicates that the spectral features of Tyrian purple on textile fibre is strictly related to the amount of this indigoid component whose content may be non invasively predicted from reflectance spectrum. The studied correlation also highlights that, independently of the dyeing method and nature of the textile fibre used, the relative content of 6,6'-dibromindigotin may be used as a parameter to distinguish samples prepared with Hexaplex trunculus L. snails from those prepared with further mollusc species. To validate this model, archaeological textile fragments dating from the Roman period were successfully examined. The results achieved open an absolutely new way in Tyrian purple analysis in cultural heritage by non invasive spectroscopic techniques attesting their convergence with HPLC and giving them a semi-quantitative value. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Convergent variational calculation of positronium-hydrogen-atom scattering lengths

    CERN Document Server

    Adhikari, S K; Adhikari, Sadhan K.; Mandal, Puspajit

    2001-01-01

    We present a convergent variational basis-set calculational scheme for elastic scattering of positronium atom by hydrogen atom in S wave. Highly correlated trial functions with appropriate symmetry are needed for achieving convergence. We report convergent results for scattering lengths in atomic units for both singlet ($=3.49\\pm 0.20$) and triplet ($=2.46\\pm 0.10$) states.

  16. Surface meshing with curvature convergence

    KAUST Repository

    Li, Huibin

    2014-06-01

    Surface meshing plays a fundamental role in graphics and visualization. Many geometric processing tasks involve solving geometric PDEs on meshes. The numerical stability, convergence rates and approximation errors are largely determined by the mesh qualities. In practice, Delaunay refinement algorithms offer satisfactory solutions to high quality mesh generations. The theoretical proofs for volume based and surface based Delaunay refinement algorithms have been established, but those for conformal parameterization based ones remain wide open. This work focuses on the curvature measure convergence for the conformal parameterization based Delaunay refinement algorithms. Given a metric surface, the proposed approach triangulates its conformal uniformization domain by the planar Delaunay refinement algorithms, and produces a high quality mesh. We give explicit estimates for the Hausdorff distance, the normal deviation, and the differences in curvature measures between the surface and the mesh. In contrast to the conventional results based on volumetric Delaunay refinement, our stronger estimates are independent of the mesh structure and directly guarantee the convergence of curvature measures. Meanwhile, our result on Gaussian curvature measure is intrinsic to the Riemannian metric and independent of the embedding. In practice, our meshing algorithm is much easier to implement and much more efficient. The experimental results verified our theoretical results and demonstrated the efficiency of the meshing algorithm. © 2014 IEEE.

  17. Converging towards the future

    Energy Technology Data Exchange (ETDEWEB)

    Gale, R. W.

    1997-05-01

    The likelihood of convergence in the electric power industry in Canada and the United Sates was examined, and the impact of such a development with respect to electricity and natural gas was explored. Based on developments to date, convergence between gas and electric utilities was considered an inevitable step towards the ultimate consolidation of the energy industry as a whole. Characteristics shared by gas and electric utilities were described, and likely developments leading to convergence of the two industries were reviewed. According to this author the competition between the opposing utilities will lead to price wars, loss leaders and other marketing strategies. Prices will be set by supply and demand principles. While users will be able to select customized, money-saving energy solutions, for suppliers, the new utility market will be a Darwinian battle royale, where only the most viable will survive. The end result will be a larger market dominated by a few super players.

  18. Validation of the fatigue scale for motor and cognitive functions in a danish multiple sclerosis cohort

    DEFF Research Database (Denmark)

    Oervik, M. S.; Sejbaek, T.; Penner, I. K.

    2017-01-01

    ) and a healthy control cohort (n = 147). The Modified Fatigue Impact Scale (MFIS) was used as reference scale and Becks Depression Inventory-Fast Screen (BDI-FS) and Expanded Disability Status Scale (EDSS) for confounding factors. We assessed internal consistencies; convergent, divergent, and predictive validity...... positive correlations between the two fatigue scales implied high convergent validity (total scores: r = 0.851, p EDSS score; age; gender). Correcting for depression did not result in any significant adjustments of the correlations...

  19. On the Fuzzy Convergence

    Directory of Open Access Journals (Sweden)

    Abdul Hameed Q. A. Al-Tai

    2011-01-01

    Full Text Available The aim of this paper is to introduce and study the fuzzy neighborhood, the limit fuzzy number, the convergent fuzzy sequence, the bounded fuzzy sequence, and the Cauchy fuzzy sequence on the base which is adopted by Abdul Hameed (every real number r is replaced by a fuzzy number r¯ (either triangular fuzzy number or singleton fuzzy set (fuzzy point. And then, we will consider that some results respect effect of the upper sequence on the convergent fuzzy sequence, the bounded fuzzy sequence, and the Cauchy fuzzy sequence.

  20. Convergence of Networks

    DEFF Research Database (Denmark)

    Prasad, Ramjee; Ruggieri, Marina

    2008-01-01

    The paper focuses on the revolutionary changes that could characterise the future of networks. Those changes involve many aspects in the conceivement and exploitation of networks: architecture, services, technologies and modeling. The convergence of wired and wireless technologies along...... with the integration of system componennts and the convergence of services (e.g. communications and navigation) are only some of the elements that shape the perpsected mosaic. Authors delineate this vision, highlighting the presence of the space and stratospheric components and the related services as building block...

  1. Computer Literacy and the Construct Validity of a High-Stakes Computer-Based Writing Assessment

    Science.gov (United States)

    Jin, Yan; Yan, Ming

    2017-01-01

    One major threat to validity in high-stakes testing is construct-irrelevant variance. In this study we explored whether the transition from a paper-and-pencil to a computer-based test mode in a high-stakes test in China, the College English Test, has brought about variance irrelevant to the construct being assessed in this test. Analyses of the…

  2. Using Self-Concept Instruments with High-Ability College Students: Reliability and Validity Evidence

    Science.gov (United States)

    Rinn, Anne N.; Cunningham, Lindy G.

    2008-01-01

    This study investigated the reliability and validity of the academic subscales of Marsh's Self-Description Questionnaire III and Neeman and Harter's Self-Perception Profile for College Students for use with high-ability college students. Participants included 100 high-ability college students and 196 average-ability college students enrolled in a…

  3. The convergence of chaotic integrals

    CERN Document Server

    Bauer, O; Bauer, Oliver; Mainieri, Ronnie

    1995-01-01

    We review the convergence of chaotic integrals computed by Monte Carlo simulation, the trace method, dynamical zeta function, and Fredholm determinant on a simple one-dimensional example: the parabola repeller. There is a dramatic difference in convergence between these approaches. The convergence of the Monte Carlo method follows an inverse power law, whereas the trace method and dynamical zeta function converge exponentially, and the Fredholm determinant converges faster than any exponential.

  4. BCFPI Validation for a High-risk High-needs Sample of Children and Youth Admitted to Tertiary Care

    Science.gov (United States)

    Cook, Steven; Leschied, Alan W.; St. Pierre, Jeff; Stewart, Shannon L.; den Dunnen, Wendy; Johnson, Andrew M.

    2013-01-01

    Objective: This study examined the validity and reliability of the Brief Child and Family Phone Interview (BCFPI) in a sample of high-risk, high-need children and youth admitted to a tertiary residential psychiatric facility. This is the first validation study of the BCFPI with children and youth functioning at the extreme clinical range. Method: Participants consisted of children and youth in a southwestern Ontario tertiary residential mental health facility. Two hundred twenty seven children and youth aged 6.28 to 16.74 (M = 12.06 years, SD = 2.46) were evaluated. Internal consistencies of each scale were tested using Cronbach’s alpha, and subsequently confirmed with unidimensional principal components analyses. Concurrent validity was evaluated through Pearson product-moment correlations between each subscale and the empirically validated subscales in the Conners’ Rating Scales. Results: With exception of the conduct subscale (alpha =.68), all Cronbach’s alpha estimates were in the acceptable range. Each scale demonstrated acceptable factor loadings on a single-factor principal components extraction derived from the pool of items within each scale. Concurrent validity was evidenced by moderate to strong correlations identified with selected measures of the Conners’ Parent Rating Scale. Conclusions: Considered together, the results of this study indicate that the BCFPI is a reliable and valid indicator of child functioning within this client population, and is recommended in the assessment of tertiary populations. PMID:23667361

  5. High-resolution multi-band imaging for validation and characterization of small Kepler planets

    Energy Technology Data Exchange (ETDEWEB)

    Everett, Mark E.; Silva, David R. [National Optical Astronomy Observatory, 950 North Cherry Avenue Tucson, AZ 85719 (United States); Barclay, Thomas; Howell, Steve B. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Ciardi, David R. [NASA Exoplanet Science Institute, 770 South Wilson Avenue, Pasadena, CA 91125 (United States); Horch, Elliott P. [Department of Physics, Southern Connecticut State University, 501 Crescent Street, New Haven, CT 06515 (United States); Crepp, Justin R. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States)

    2015-02-01

    High-resolution ground-based optical speckle and near-infrared adaptive optics images are taken to search for stars in close angular proximity to host stars of candidate planets identified by the NASA Kepler Mission. Neighboring stars are a potential source of false positive signals. These stars also blend into Kepler light curves, affecting estimated planet properties, and are important for an understanding of planets in multiple star systems. Deep images with high angular resolution help to validate candidate planets by excluding potential background eclipsing binaries as the source of the transit signals. A study of 18 Kepler Object of Interest stars hosting a total of 28 candidate and validated planets is presented. Validation levels are determined for 18 planets against the likelihood of a false positive from a background eclipsing binary. Most of these are validated at the 99% level or higher, including five newly validated planets in two systems: Kepler-430 and Kepler-431. The stellar properties of the candidate host stars are determined by supplementing existing literature values with new spectroscopic characterizations. Close neighbors of seven of these stars are examined using multi-wavelength photometry to determine their nature and influence on the candidate planet properties. Most of the close neighbors appear to be gravitationally bound secondaries, while a few are best explained as closely co-aligned field stars. Revised planet properties are derived for each candidate and validated planet, including cases where the close neighbors are the potential host stars.

  6. The Convergence Years

    Science.gov (United States)

    Kolodzy, Janet; Grant, August E.; DeMars, Tony R.; Wilkinson, Jeffrey S.

    2014-01-01

    The emergence of the Internet, social media, and digital technologies in the twenty-first century accelerated an evolution in journalism and communication that fit under the broad term of convergence. That evolution changed the relationship between news producers and consumers. It broke down the geographical boundaries in defining our communities,…

  7. Convergent Filter Bases

    OpenAIRE

    Coghetto Roland

    2015-01-01

    We are inspired by the work of Henri Cartan [16], Bourbaki [10] (TG. I Filtres) and Claude Wagschal [34]. We define the base of filter, image filter, convergent filter bases, limit filter and the filter base of tails (fr: filtre des sections).

  8. Convergence of Networks

    DEFF Research Database (Denmark)

    Prasad, Ramjee; Ruggieri, Marina

    2008-01-01

    with the integration of system componennts and the convergence of services (e.g. communications and navigation) are only some of the elements that shape the perpsected mosaic. Authors delineate this vision, highlighting the presence of the space and stratospheric components and the related services as building block...

  9. Convergent Filter Bases

    Directory of Open Access Journals (Sweden)

    Coghetto Roland

    2015-09-01

    Full Text Available We are inspired by the work of Henri Cartan [16], Bourbaki [10] (TG. I Filtres and Claude Wagschal [34]. We define the base of filter, image filter, convergent filter bases, limit filter and the filter base of tails (fr: filtre des sections.

  10. Language Convergence Infrastructure

    NARCIS (Netherlands)

    V. Zaytsev (Vadim); J.M. Fernandes; R. Lämmel (Ralf); J.M.W. Visser (Joost); J. Saraiva

    2011-01-01

    htmlabstractThe process of grammar convergence involves grammar extraction and transformation for structural equivalence and contains a range of technical challenges. These need to be addressed in order for the method to deliver useful results. The paper describes a DSL and the infrastructure behind

  11. Convergence of Arnoldi method

    Energy Technology Data Exchange (ETDEWEB)

    Nevanlinna, O. [Helsinki Univ. of Technology, Espoo (Finland)

    1994-12-31

    This note summarizes some results on (a monitored version of) the Arnoldi method in Hilbert spaces. The interest in working in infinite dimensional spaces comes partly from the fact that only then can one have meaningful asymptotical statements (which hopefully give some light to the convergence of Arnoldi in large dimensional problems with iteration indices far less than the dimension).

  12. The Convergence Years

    Science.gov (United States)

    Kolodzy, Janet; Grant, August E.; DeMars, Tony R.; Wilkinson, Jeffrey S.

    2014-01-01

    The emergence of the Internet, social media, and digital technologies in the twenty-first century accelerated an evolution in journalism and communication that fit under the broad term of convergence. That evolution changed the relationship between news producers and consumers. It broke down the geographical boundaries in defining our communities,…

  13. Continental Subduction and Subduction Initiation Leading to Extensional Exhumation of Ultra-High Pressure Rocks During Ongoing Plate Convergence in Papua New Guinea

    Science.gov (United States)

    Buck, W. R.; Petersen, K. D.

    2014-12-01

    Subduction of continental rocks is necessary to produce ultra-high pressure (UHP) rocks but the mechanism bringing them to the surface is disputed. A major question is whether this involves fairly small diapirs of crust that move up through the mantle or it involves an entire subducted plate that undergoes coherent 'reverse subduction' (sometimes called 'eduction'). Both mechanisms have been invoked to explain the only known region of on-going exhumation of UHP rocks, on the D'Entrecasteaux Islands of Papua New Guinea. Ductile flow fabrics in the island rocks have been used to argue for a diapiric model while constraints on the plate kinematics of the region require relatively large (>100 km) amounts of recent (>6 Myr) extension, supporting eduction as a primary mechanism. A self-consistent thermo-mechanical model of continental subduction shows that eduction can be accompanied by some ductile flow within the crust. Also we show, that subduction and stacking of continental crust can cause a subduction zone to lock up and lead to subduction initiation elsewhere. When this happens the region of earlier continental subduction can reverse direction causing exhumation of rocks from depth of ~100 km followed by localized extension and plate spreading. This can occur even if a region is in overall convergence. Applied to New Guinea our results are consistent with earlier suggestions that extension of the Woodlark Basin was caused by the initiation of the New Britain Trench, as indicated on the attached figure. We suggest that this subduction initiation event triggered eduction that led to exposure of the D'Entrcasteaux Islands and exhumation of the UHP rocks there. Our numerical results are broadly consistent with the recently refined seismic structure of the region around the islands. The model implies that the present-day basement of the ~70 km wide Goodenough Bay, south of the islands, was subducted then exhumed. This can be tested by drilling.

  14. Heterogeneity and convergence of olfactory first-order neurons account for the high speed and sensitivity of second-order neurons.

    Science.gov (United States)

    Rospars, Jean-Pierre; Grémiaux, Alexandre; Jarriault, David; Chaffiol, Antoine; Monsempes, Christelle; Deisig, Nina; Anton, Sylvia; Lucas, Philippe; Martinez, Dominique

    2014-12-01

    In the olfactory system of male moths, a specialized subset of neurons detects and processes the main component of the sex pheromone emitted by females. It is composed of several thousand first-order olfactory receptor neurons (ORNs), all expressing the same pheromone receptor, that contact synaptically a few tens of second-order projection neurons (PNs) within a single restricted brain area. The functional simplicity of this system makes it a favorable model for studying the factors that contribute to its exquisite sensitivity and speed. Sensory information--primarily the identity and intensity of the stimulus--is encoded as the firing rate of the action potentials, and possibly as the latency of the neuron response. We found that over all their dynamic range, PNs respond with a shorter latency and a higher firing rate than most ORNs. Modelling showed that the increased sensitivity of PNs can be explained by the ORN-to-PN convergent architecture alone, whereas their faster response also requires cell-to-cell heterogeneity of the ORN population. So, far from being detrimental to signal detection, the ORN heterogeneity is exploited by PNs, and results in two different schemes of population coding based either on the response of a few extreme neurons (latency) or on the average response of many (firing rate). Moreover, ORN-to-PN transformations are linear for latency and nonlinear for firing rate, suggesting that latency could be involved in concentration-invariant coding of the pheromone blend and that sensitivity at low concentrations is achieved at the expense of precise encoding at high concentrations.

  15. Heterogeneity and convergence of olfactory first-order neurons account for the high speed and sensitivity of second-order neurons.

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Rospars

    2014-12-01

    Full Text Available In the olfactory system of male moths, a specialized subset of neurons detects and processes the main component of the sex pheromone emitted by females. It is composed of several thousand first-order olfactory receptor neurons (ORNs, all expressing the same pheromone receptor, that contact synaptically a few tens of second-order projection neurons (PNs within a single restricted brain area. The functional simplicity of this system makes it a favorable model for studying the factors that contribute to its exquisite sensitivity and speed. Sensory information--primarily the identity and intensity of the stimulus--is encoded as the firing rate of the action potentials, and possibly as the latency of the neuron response. We found that over all their dynamic range, PNs respond with a shorter latency and a higher firing rate than most ORNs. Modelling showed that the increased sensitivity of PNs can be explained by the ORN-to-PN convergent architecture alone, whereas their faster response also requires cell-to-cell heterogeneity of the ORN population. So, far from being detrimental to signal detection, the ORN heterogeneity is exploited by PNs, and results in two different schemes of population coding based either on the response of a few extreme neurons (latency or on the average response of many (firing rate. Moreover, ORN-to-PN transformations are linear for latency and nonlinear for firing rate, suggesting that latency could be involved in concentration-invariant coding of the pheromone blend and that sensitivity at low concentrations is achieved at the expense of precise encoding at high concentrations.

  16. Electro-thermal modeling of high power IGBT module short-circuits with experimental validation

    DEFF Research Database (Denmark)

    Wu, Rui; Iannuzzo, Francesco; Wang, Huai

    2015-01-01

    A novel Insulated Gate Bipolar Transistor (IGBT) electro-thermal modeling approach involving PSpice and ANSYS/Icepak with both high accuracy and simulation speed has been presented to study short-circuit of a 1.7 kV/1 kA commercial IGBT module. The approach successfully predicts the current...... and temperature distribution inside the chip of power IGBT modules. The simulation result is further validated using a 6 kA/1.1 kV non-destructive tester. The experimental validation demonstrates the modeling approach’s capability for reliable design of high power IGBT power modules given electrical...

  17. Validity of the malnutrition screening tool for older adults at high risk of hospital readmission.

    Science.gov (United States)

    Wu, Min-Lin; Courtney, Mary D; Shortridge-Baggett, Lillie M; Finlayson, Kathleen; Isenring, Elisabeth A

    2012-06-01

    Malnutrition is a serious problem in older adults, particularly for those at risk of hospital readmission. The essential step in managing malnutrition is early identification using a valid nutrition screening tool. The purpose of this study was to validate the Malnutrition Screening Tool (MST) in older adults at high risk of hospital readmission. Two RNs administered the MST to identify malnutrition risk and compared it with the comprehensive Subjective Global Assessment (SGA) to assess nutritional status for patients 65 and older who had at least one risk factor for hospital readmission. The MST demonstrates substantial sensitivity, specificity, and agreement with the SGA. These findings indicate that nursing staff can use the MST as a valid tool for routine screening and rescreening to identify patients at risk of malnutrition. Use of the MST may prevent hospital-acquired malnutrition in acute hospitalized older adults at high risk of readmission.

  18. Summable series and convergence factors

    CERN Document Server

    Moore, Charles N

    1938-01-01

    Fairly early in the development of the theory of summability of divergent series, the concept of convergence factors was recognized as of fundamental importance in the subject. One of the pioneers in this field was C. N. Moore, the author of the book under review.... Moore classifies convergence factors into two types. In type I he places the factors which have only the property that they preserve convergence for a convergent series or produce convergence for a summable series. In type II he places the factors which not only maintain or produce convergence but have the additional property that

  19. Validity Inferences under High-Stakes Conditions: A Response from Language Testing

    Science.gov (United States)

    Hill, Kathryn; McNamara, Tim

    2015-01-01

    Those who work in second- and foreign-language testing often find Koretz's concern for validity inferences under high-stakes (VIHS) conditions both welcome and familiar. While the focus of the article is more narrowly on the potential for two instructional responses to test-based accountability, "reallocation" and "coaching,"…

  20. Social Validity Assessment of Mindfulness Education and Practices among High School Students

    Science.gov (United States)

    Luiselli, James K.; Worthen, Douglas; Carbonell, Lauren; Queen, Alexander H.

    2017-01-01

    The authors describe social validity assessment of mindfulness education and practices among high school students (N = 84) participating in a 10-week instructional program. The participants rated their satisfaction with and acceptance of several program components, content areas, and outcomes, as well as their engagement in specific mindfulness…

  1. Social Validity Assessment of Mindfulness Education and Practices among High School Students

    Science.gov (United States)

    Luiselli, James K.; Worthen, Douglas; Carbonell, Lauren; Queen, Alexander H.

    2017-01-01

    The authors describe social validity assessment of mindfulness education and practices among high school students (N = 84) participating in a 10-week instructional program. The participants rated their satisfaction with and acceptance of several program components, content areas, and outcomes, as well as their engagement in specific mindfulness…

  2. Validity Inferences under High-Stakes Conditions: A Response from Language Testing

    Science.gov (United States)

    Hill, Kathryn; McNamara, Tim

    2015-01-01

    Those who work in second- and foreign-language testing often find Koretz's concern for validity inferences under high-stakes (VIHS) conditions both welcome and familiar. While the focus of the article is more narrowly on the potential for two instructional responses to test-based accountability, "reallocation" and "coaching,"…

  3. VATE: VAlidation of high TEchnology based on large database analysis by learning machine

    NARCIS (Netherlands)

    Meldolesi, E; Van Soest, J; Alitto, A R; Autorino, R; Dinapoli, N; Dekker, A; Gambacorta, M A; Gatta, R; Tagliaferri, L; Damiani, A; Valentini, V

    2014-01-01

    The interaction between implementation of new technologies and different outcomes can allow a broad range of researches to be expanded. The purpose of this paper is to introduce the VAlidation of high TEchnology based on large database analysis by learning machine (VATE) project that aims to combine

  4. The Convergent Learning Space:

    DEFF Research Database (Denmark)

    Kjærgaard, Hanne Wacher; Kjeldsen, Lars Peter; Asmussen, Jørgen Bering

    2013-01-01

    is described as well as the theoretical construct and hypotheses surrounding the emergence of the concept in technology-rich classrooms, where students bring their own devices and involve their personal learning spaces and networks. The need for new ways of approaching concepts like choice, learning resources......This paper describes the concept of “The Convergent Learning Space” as it is being explored in an ongoing action research project carried out at undergraduate level in select bachelor programs at a Danish University College. The background nature, design, and beginning of this work in progress......, trajectories of participation etc. calls for new action and new pedagogies by teachers in order to secure alignment between students’ worlds and expectations and aims and plans of the teacher. Action research methods are being used to define and test the constituents and variables of the convergent learning...

  5. Subsequential Convergence Conditions

    Directory of Open Access Journals (Sweden)

    İbrahim Çanak

    2007-10-01

    Full Text Available Let (un be a sequence of real numbers and let L be any (C,1 regular limitable method. We prove that, under some assumptions, if a sequence (un or its generator sequence (Vn(0(Δu generated regularly by a sequence in a class 𝒜 of sequences is a subsequential convergence condition for L, then for any integer m≥1, the mth repeated arithmetic means of (Vn(0(Δu, (Vn(m(Δu, generated regularly by a sequence in the class 𝒜(m, is also a subsequential convergence condition for L.

  6. Convergence Reflects Maturity

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Competition has been playing a dominant role among telecommunication equipment manufacturers. In 2006, however, merger overwhelmed competition. In the tide of converging, a large number of equipment manufacturers were involved in mergers. At the same time, telecommunication equipment manufacturers, the most innovative community in the world, drive 3G technology fast in line with its technical roadmap. In addition, Chinese equipment manufacturers cut a figure in world-class telecommunication markets, whic...

  7. Development of interpersonal problem solving inventory for high school students: The validity and reliability process

    Directory of Open Access Journals (Sweden)

    Sabahattin Çam

    2008-07-01

    Full Text Available The current study investigated reliability and validity of an inventory to measure high school students' problem solving strategies and abilities with Interpersonal Problem Solving Inventory (IPSI, which is originally developed to assess college students' problem solving strategies and abilities. IPSI consist of 50 items constructed in a form of 5 sub-scale. These five sub-scales are called; Approaching problems in a negative way, Constructive problem solving, Lack of self-confidence, Unwilling to take responsibility, and Insistent-persevering approach. The sample consist of 482 pupils, 48.1 % of boys (232, 51.9 % of girls (250. % 34.2 of these students were in 9th grade, %33.8 of them were in 10th grade, and %32 of them were in 11th grade. The results of confirmatory factor analysis (CFA show that the scale consists of five interpersonal problem solving. The relationships between sub-scale scores of high school student showed similar results to the college students' sub-scale score.  Confirmatory factor analysis, criterion validity, similar and different structure validity of the sub-scales were proved. The internal consistency values of Cronbach Alfa for the sub-scales are found between .67 and .89; the test-retest reliability is found between .67 and .84. The reliability and validity of the inventory showed that five sub-scales have the ability to measure the interpersonal problem solving ability and behavior for high school students.

  8. Validation of a novel automatic sleep spindle detector with high performance during sleep in middle aged subjects

    DEFF Research Database (Denmark)

    Wendt, Sabrina Lyngbye; Christensen, Julie A. E.; Kempfner, Jacob

    2012-01-01

    Many of the automatic sleep spindle detectors currently used to analyze sleep EEG are either validated on young subjects or not validated thoroughly. The purpose of this study is to develop and validate a fast and reliable sleep spindle detector with high performance in middle aged subjects. An a...

  9. Knowledge Convergence and Collaborative Learning

    Science.gov (United States)

    Jeong, Heisawn; Chi, Michelene T. H.

    2007-01-01

    This paper operationalized the notion of knowledge convergence and assessed quantitatively how much knowledge convergence occurred during collaborative learning. Knowledge convergence was defined as an increase in common knowledge where common knowledge referred to the knowledge that all collaborating partners had. Twenty pairs of college students…

  10. Regional disparities and convergences in America

    Directory of Open Access Journals (Sweden)

    Petr Blížkovský

    2012-01-01

    Full Text Available This paper analyses the levels and trends of regional disparity and convergence in the two American macro-regions, NAFTA and MERCOSUR. In the case of NAFTA, 95 micro-regions were analysed (12 in Canada; 32 in Mexico; 51 states in the US. In MERCOSUR, the regions are represented by four countries (Argentina, Brazil, Paraguay and Uruguay. The analysis covers the period 2000–2008 (or rather 2000 to 2005 for Mexico. The regional disparities were calculated with the Gini coefficient based on nominal GDP, GDP per capita and GDP per capita PPS. Convergence analysis was done with the Disparity Range Coefficient (DRC, the Average Disparity Range Coefficient (ADRC, σ- convergence and β-convergence. The results of regional disparity were as follows. Based on the nominal GDP, it was at high levels in both macro-regions, with a Gini coefficient above 0.55. With the disparities calculated on GDP per capita, the level of regional disparity in both macro-regions was lower at 0.36 in NAFTA and 0.28 in MERCOSUR in 2000. Based on GDP per capita in PPP, the levels were lower than based on the GDP per capita analysis starting at 0.31 in NAFTA and 0.16 in MERCOSUR. The disparities further decreased by half in NAFTA while slightly increasing in MERSCOSUR. The convergence analysis results based on the DRC analysis showed that neither NAFTA nor MERCOSUR regions converged. The speed of divergence varied significantly. The disparities among the richest and poorest regions in GDP per capita increased 6.26 times more than the average GDP per capita in PPP in NAFTA as a whole. It was only 0.52 in MERCOSUR. The ADRC analysis also resulted in divergence trends for both macro-regions but with lower rates. Convergence calculated with the σ- convergence analysis confirmed that both macro-regions diverged. The divergence rate for NAFTA was 1.41% and for MERCOSUR 0.74. Calculated with the β-convergence analysis, the NAFTA region showed a status quo (convergence of 0.01% and a

  11. Calibration of a γ-Reθ transition model and its validation in low-speed flows with high-order numerical method

    Directory of Open Access Journals (Sweden)

    Wang Yuntao

    2015-06-01

    Full Text Available Based on the Reynolds-averaged Navier–Stokes (RANS equations and structured grid technology, the calibration and validation of γ-Reθ transition model is preformed with fifth-order weighted compact nonlinear scheme (WCNS, and the purpose of the present work is to improve the numerical accuracy for aerodynamic characteristics simulation of low-speed flow with transition model on the basis of high-order numerical method study. Firstly, the empirical correlation functions involved in the γ-Reθ transition model are modified and calibrated with experimental data of turbulent flat plates. Then, the grid convergence is studied on NLR-7301 two-element airfoil with the modified empirical correlation. At last, the modified empirical correlation is validated with NLR-7301 two-element airfoil and high-lift trapezoidal wing from transition location, velocity profile in boundary layer, surface pressure coefficient and aerodynamic characteristics. The numerical results illustrate that the numerical accuracy of transition length and skin friction behind transition location are improved with modified empirical correlation function, and obviously increases the numerical accuracy of aerodynamic characteristics prediction for typical transport configurations in low-speed range.

  12. Validating Steady-State and Transient Modeling Tools for High-Power-Density Thermoelectric Generators

    Science.gov (United States)

    Crane, D. T.; Koripella, C. R.; Jovovic, V.

    2012-06-01

    Steady-state and transient models have been created in a MATLAB/Simulink environment for high-power-density thermoelectric generators (TEG). These numerical models, comprising simultaneously solved, nonlinear, energy balance equations, simulate novel TEG architectures, such as a cylindrical TEG with gas/liquid heat exchangers. Model validation studies, including component-level testing of thermoelectric (TE) subassemblies, interface thermal resistance tests, and full-scale TEG tests, were performed under different operating conditions and designs. Targeted finite-element analysis studies were also conducted. A full-scale cylindrical-shaped TE generator was built using high-power-density, segmented TE elements and tested on a test-bench with hot air and cold water with maximum power output of 608 W. Measured performance data from these tests were used in model validation. Process outlet temperatures, pressure drops, hot and cold shunt temperatures along the length of the TEG, TEG voltage, and TEG current are some of the performance variables included in the model validation. The validated model is now being used with more confidence to optimize new TEG designs for different applications.

  13. The effects of convergence ratio on the implosion behavior of DT layered inertial confinement fusion capsules

    Science.gov (United States)

    Haines, Brian M.; Yi, S. A.; Olson, R. E.; Khan, S. F.; Kyrala, G. A.; Zylstra, A. B.; Bradley, P. A.; Peterson, R. R.; Kline, J. L.; Leeper, R. J.; Shah, R. C.

    2017-07-01

    The wetted foam capsule design for inertial confinement fusion capsules, which includes a foam layer wetted with deuterium-tritium liquid, enables layered capsule implosions with a wide range of hot-spot convergence ratios (CR) on the National Ignition Facility. We present a full-scale wetted foam capsule design that demonstrates high gain in one-dimensional simulations. In these simulations, increasing the convergence ratio leads to an improved capsule yield due to higher hot-spot temperatures and increased fuel areal density. High-resolution two-dimensional simulations of this design are presented with detailed and well resolved models for the capsule fill tube, support tent, surface roughness, and predicted asymmetries in the x-ray drive. Our modeling of these asymmetries is validated by comparisons with available experimental data. In 2D simulations of the full-scale wetted foam capsule design, jetting caused by the fill tube is prevented by the expansion of the tungsten-doped shell layer due to preheat. While the impacts of surface roughness and predicted asymmetries in the x-ray drive are enhanced by convergence effects, likely underpredicted in 2D at high CR, simulations predict that the capsule is robust to these features. Nevertheless, the design is highly susceptible to the effects of the capsule support tent, which negates all of the one-dimensional benefits of increasing the convergence ratio. Indeed, when the support tent is included in simulations, the yield decreases as the convergence ratio is increased for CR > 20. Nevertheless, the results suggest that the full-scale wetted foam design has the potential to outperform ice layer capsules given currently achievable levels of asymmetries when fielded at low convergence ratios (CR < 20).

  14. Medialogy - convergence and transdisciplinarity

    DEFF Research Database (Denmark)

    Nordahl, Rolf

    2007-01-01

    for changes in society, developments in taste etc.  However, it certainly seems fair to say, that available technology makes a great difference to the development of any art form or practice. With the up rise of new educations such as Medialogy, new aspects of convergence and different forms...... of interdisciplinarity and transdisciplinarity is a pre-requisite for both researchers and students. In this talk we will demonstrate our approach through concrete examples of student productions and projects. We will also display the pedagogical method (problem based learning), that enables students to bridge gaps...... between art and science....

  15. 带电清扫机器人液压自动调平收敛性研究%Research on the Convergence of Hydraulic Automatic Levelling System for High-voltage Cleaning Robot

    Institute of Scientific and Technical Information of China (English)

    汤君茂; 翁新华; 杨汝清

    2009-01-01

    High-voltage cleaning robot needs a horizontal platform, but it is hard to ensure the convergence of a hydraulic automatic levelling system. Thus,this paper analysed the three key problems: platform modelling, movement coupling, characteristics of the leg's velocity. And then, this paper designed a control algorithm to solve the convergence problem. According to the results of experiments, the algorithm can ensure the convergence and keep the high precision and speed.%针对带电清扫机器人作业过程中对平台水平度的要求,以及液压调平系统收敛性难以保证的现状,在对平台模型的建立、运动耦合和支腿速度特性进行研究的基础上,提出了一种确保系统收敛性的控制方法.实验结果表明该方法能够确保液压自动调平系统的收敛性,而且调平精度高、速度快.

  16. Convergence of Wachspress coordinates: from polygons to curved domains

    KAUST Repository

    Kosinka, Jiří

    2014-08-08

    Given a smooth, strictly convex planar domain, we investigate point-wise convergence of the sequence of Wachspress coordinates defined over finer and finer inscribed polygonal approximations of the domain. Based on a relation between the discrete Wachspress case and the limit smooth case given by the Wachspress kernel defined by Warren et al., we show that the corresponding sequences of Wachspress interpolants and mappings converge as 𝓞(h2) for a sampling step size h of the boundary curve of the domain as h → 0. Several examples are shown to numerically validate the results and to visualise the behaviour of discrete interpolants and mappings as they converge to their smooth counterparts. Empirically, the same convergence order is observed also for mean value coordinates. Moreover, our numerical tests suggest that the convergence of interpolants and mappings is uniform both in the Wachspress and mean value cases. © 2014 Springer Science+Business Media New York.

  17. The Validity and Incremental Validity of Knowledge Tests, Low-Fidelity Simulations, and High-Fidelity Simulations for Predicting Job Performance in Advanced-Level High-Stakes Selection

    Science.gov (United States)

    Lievens, Filip; Patterson, Fiona

    2011-01-01

    In high-stakes selection among candidates with considerable domain-specific knowledge and experience, investigations of whether high-fidelity simulations (assessment centers; ACs) have incremental validity over low-fidelity simulations (situational judgment tests; SJTs) are lacking. Therefore, this article integrates research on the validity of…

  18. The Validity and Incremental Validity of Knowledge Tests, Low-Fidelity Simulations, and High-Fidelity Simulations for Predicting Job Performance in Advanced-Level High-Stakes Selection

    Science.gov (United States)

    Lievens, Filip; Patterson, Fiona

    2011-01-01

    In high-stakes selection among candidates with considerable domain-specific knowledge and experience, investigations of whether high-fidelity simulations (assessment centers; ACs) have incremental validity over low-fidelity simulations (situational judgment tests; SJTs) are lacking. Therefore, this article integrates research on the validity of…

  19. The Canadian Arctic ACE/OSIRIS Validation Project at PEARL: Validating Satellite Observations Over the High Arctic

    Science.gov (United States)

    Walker, Kaley A.; Strong, Kimberly; Fogal, Pierre F.; Drummond, James R.

    2016-04-01

    Ground-based measurements provide critical data for the validation of satellite retrievals of atmospheric trace gases and for the assessment of long-term stability of these measurements. As of February 2016, the Canadian-led Atmospheric Chemistry Experiment (ACE) satellite mission has been making measurements of the Earth's atmosphere for nearly twelve years and Canada's Optical Spectrograph and InfraRed Imager System (OSIRIS) instrument on the Odin satellite has been operating for fourteen years. As ACE and OSIRIS operations have extended beyond their planned two-year missions, there is an ongoing need to validate the trace gas data profiles from the ACE-Fourier Transform Spectrometer (ACE-FTS), the Measurement of Aerosol Extinction in the Stratosphere and Troposphere Retrieved by Occultation (ACE-MAESTRO) and OSIRIS. In particular, validation comparisons are needed during Arctic springtime to understand better the measurements of species involved in stratospheric ozone chemistry. To this end, thirteen Canadian Arctic ACE/OSIRIS Validation Campaigns have been conducted during the spring period (February - April in 2004 - 2016) at the Polar Environment Atmospheric Research Laboratory (PEARL) in Eureka, Nunavut (80N, 86W). For the past decade, these campaigns have been undertaken in collaboration with the Canadian Network for the Detection of Atmospheric Change (CANDAC). The spring period coincides with the most chemically active time of year in the Arctic, as well as a significant number of satellite overpasses. A suite of as many as 12 ground-based instruments, as well as frequent balloon-borne ozonesonde and radiosonde launches, have been used in each campaign. These instruments include: a ground-based version of the ACE-FTS (PARIS - Portable Atmospheric Research Interferometric Spectrometer), a terrestrial version of the ACE-MAESTRO, a SunPhotoSpectrometer, two CANDAC zenith-viewing UV-visible grating spectrometers, a Bomem DA8 Fourier transform spectrometer

  20. A validated high performance thin layer chromatography method for determination of yohimbine hydrochloride in pharmaceutical preparations

    OpenAIRE

    Badr, Jihan M.

    2013-01-01

    Background: Yohimbine is an indole alkaloid used as a promising therapy for erectile dysfunction. A number of methods were reported for the analysis of yohimbine in the bark or in pharmaceutical preparations. Materials and Method: In the present work, a simple and sensitive high performance thin layer chromatographic method is developed for determination of yohimbine (occurring as yohimbine hydrochloride) in pharmaceutical preparations and validated according to International Conference of Ha...

  1. Music Performance Anxiety Scale for High School Students: Validity and Reliability Study

    Directory of Open Access Journals (Sweden)

    Mehmet Palancı

    2015-01-01

    Full Text Available This study aims to develop a Music Performance Anxiety Scale (MPAS for high school students, and to conduct a validity and reliability study. In this respect, a scale will be developed to be used for high school students (adolescents, and differences between the genders will be examined. The study was conducted on 546 high school students. Of these students, 185 (33.9% were male, 361 (66.1% were female, and the average age was 16.81 with the ages ranging from 15 to 20. Correlational values of the scale items among themselves and with item totals were examined as a preliminary analysis. As a result of the EFA’s principal components technique, promax rotation technique and the analyses, a construct with three factors explaining a total of 42.74% of the total variance was attained. The structure attained was validated by CFA, and fit indices were found to be within the acceptance interval. In the reliability study, Cronbach’s alpha internal consistency coefficient was calculated as .86 for the entire scale, 27% for the lower-upper group comparison and test-retest analyses were conducted. The t-test was performed to attain the difference between genders. As a result of the study, a valid and reliable scale was seen to have been developed and a difference between the genders was apparent.

  2. Investigating the deformation of upper crustal faults at the N-Chilean convergent plate boundary at different scales using high-resolution topography datasets and creepmeter measurements

    Science.gov (United States)

    Ewiak, O.; Victor, P.; Ziegenhagen, T.; Oncken, O.

    2012-04-01

    The Chilean convergent plate boundary is one of the tectonically most active regions on earth and prone to large megathrust earthquakes as e. g. the 2010 Mw 8.8 Maule earthquake which ruptured a mature seismic gap in south-central Chile. In northern Chile historical data suggests the existence of a seismic gap between Arica and Mejillones Peninsula (MP), which has not ruptured since 1877. Further south, the 1995 Mw 8.0 Antofagasta earthquake ruptured the subduction interface between MP and Taltal. In this study we investigate the deformation at four active upper plate faults (dip-slip and strike-slip) located above the coupling zone of the subduction interface. The target faults (Mejillones Fault - MF, Salar del Carmen Fault - SCF, Cerro Fortuna Fault - CFF, Chomache Fault - CF) are situated in forearc segments, which are in different stages of the megathrust seismic cycle. The main question of this study is how strain is accumulated in the overriding plate, what is the response of the target faults to the megathrust seismic cycle and what are the mechanisms / processes involved. The hyper arid conditions of the Atacama desert and the extremely low erosion rates enable us to investigate geomorphic markers, e .g. fault scarps and knickpoints, which serve as a record for upper crustal deformation and fault activity about ten thousands years into the past. Fault scarp data has been acquired with Differential-GPS by measuring high-resolution topographic profiles perpendicular to the fault scarps and along incised gullies. The topographic data show clear variations between the target faults which possibly result from their position within the forearc. The surveyed faults, e. g. the SCF, exhibit clear along strike variations in the morphology of surface ruptures attributed to seismic events and can be subdivided into individual segments. The data allows us to distinguish single, composite and multiple fault scarps and thus to detect differences in fault growth initiated

  3. High-performance liquid chromatography method validation for determination of tetracycline residues in poultry meat

    Directory of Open Access Journals (Sweden)

    Vikas Gupta

    2014-01-01

    Full Text Available Background: In this study, a method for determination of tetracycline (TC residues in poultry with the help of high-performance liquid chromatography technique was validated. Materials and Methods: The principle step involved in ultrasonic-assisted extraction of TCs from poultry samples by 2 ml of 20% trichloroacetic acid and phosphate buffer (pH 4, which gave a clearer supernatant and high recovery, followed by centrifugation and purification by using 0.22 μm filter paper. Results: Validity study of the method revealed that all obtained calibration curves showed good linearity (r2 > 0.999 over the range of 40-4500 ng. Sensitivity was found to be 1.54 and 1.80 ng for oxytetracycline (OTC and TC. Accuracy was in the range of 87.94-96.20% and 72.40-79.84% for meat. Precision was lower than 10% in all cases indicating that the method can be used as a validated method. Limit of detection was found to be 4.8 and 5.10 ng for OTC and TC, respectively. The corresponding values of limit of quantitation were 11 and 12 ng. Conclusion: The method reliably identifies and quantifies the selected TC and OTC in the reconstituted poultry meat in the low and sub-nanogram range and can be applied in any laboratory.

  4. The Construction and Validation of Opium Attitude Questionnaire among Guidance and High School Students

    Directory of Open Access Journals (Sweden)

    Ali Mohammad Rezaee

    2013-01-01

    Full Text Available Aim: The study was aimed to determine the validity and reliability of opium attitudes questionnaire. Method: 6108 of guidance school (3th grades and high school students filled the opium attitude questionnaire in all of the country. The validity of questionnaire assessed by group discrimination and confirmatory factor analysis method. Results: the results of group discrimination showed that the questions can be discriminated of past and current opium addicts and normal groups. On the basis of factor analysis results 5 factors extracted. These factors with consideration of literature review and loaded items content named: interest to consume, attitude to dangers, attitude to physiological effects, attitude to psychic effects, attitude to social effects to opium. Reliability of subscales examined by Cronbakh’s alpha. The minimum measure of reliability was 0.77 and maximum was 0.86. Altogether, the validity and reliability of questionnaire were satisfied. Conclusion: On the basis of present research results, opium attitude questionnaire is appropriate for assessing of students’ attitude to opium among guidance and high school students.

  5. Convergence as Organization

    DEFF Research Database (Denmark)

    Harrison, Yannick Nehemiah Antonio; Risager, Bjarke Skærlund

    2016-01-01

    . The article is based on participant observation of the Blockupy event and interviews with a group of Danish activists who also participated. The article constructs sociospatial narrative that unfolds through three different scales of organization: the Blockupy coalition, the participating formal and informal...... organizations, and the activist subject. This narrative explicates the mode of organization as a ‘convergence space’ (cf. Routledge, 2003), with different ‘roots’ and ‘routes’ of organization (cf. Davies, 2012). Thus, through an analysis of the modes of organization constituting this mass protest event......, this article restates the relevance of the concept of organization, which have recently been ignored or understated in favour of master-narratives of networks or the dichotomy of horizontalism and verticality. It concludes by posing a set of questions for further discussion among both activists...

  6. Homology, convergence and parallelism.

    Science.gov (United States)

    Ghiselin, Michael T

    2016-01-05

    Homology is a relation of correspondence between parts of parts of larger wholes. It is used when tracking objects of interest through space and time and in the context of explanatory historical narratives. Homologues can be traced through a genealogical nexus back to a common ancestral precursor. Homology being a transitive relation, homologues remain homologous however much they may come to differ. Analogy is a relationship of correspondence between parts of members of classes having no relationship of common ancestry. Although homology is often treated as an alternative to convergence, the latter is not a kind of correspondence: rather, it is one of a class of processes that also includes divergence and parallelism. These often give rise to misleading appearances (homoplasies). Parallelism can be particularly hard to detect, especially when not accompanied by divergences in some parts of the body. © 2015 The Author(s).

  7. RCCS Experiments and Validation for High Temperature Gas-Cooled Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chang Oh; Cliff Davis; Goon C. Park

    2007-09-01

    A reactor cavity cooling system (RCCS), an air-cooled helical coil RCCS unit immersed in the water pool, was proposed to overcome the disadvantages of the weak cooling ability of air-cooled RCCS and the complex structure of water-cooled RCCS for the high temperature gas-cooled reactor (HTGR). An experimental apparatus was constructed to investigate the various heat transfer phenomena in the water pool type RCCS, such as the natural convection of air inside the cavity, radiation in the cavity, the natural convection of water in the water pool and the forced convection of air in the cooling pipe. The RCCS experimental results were compared with published correlations. The CFX code was validated using data from the air-cooled portion of the RCCS. The RELAP5 code was validated using measured temperatures from the reactor vessel and cavity walls.

  8. A validated new method for nevirapine quantitation in human plasma via high-performance liquid chromatography.

    Science.gov (United States)

    Silverthorn, Courtney F; Parsons, Teresa L

    2006-01-01

    A fully validated and clinically relevant assay was developed for the assessment of nevirapine concentrations in neonate blood plasma samples. Solid-phase extraction with an acid-base wash series was used to prepare subject samples for analysis. Samples were separated by high performance liquid chromatography and detected at 280 nm on a C8 reverse-phase column in an isocratic mobile phase. The retention times of nevirapine and its internal standard were 5.0 and 6.9 min, respectively. The method was validated by assessment of accuracy and precision (statistical values 0.996) and the average recovery was 93% (n = 18). The lower limit of quantification (relative standard deviation <20%) was determined to be 25 ng/mL for 50 microL of plasma, allowing detection of as little as 1.25 ng of nevirapine in a sample. This value represents an increase in sensitivity of up to 30-fold over previously published methods.

  9. Preliminary Validation of High Performance Liquid Chromatography Method for Detection of Methyltestosterone Residue in Carp Muscle

    Institute of Scientific and Technical Information of China (English)

    JIANG Jie; LIN Hong; FU Xiaoting; LI Mingming

    2005-01-01

    The use of synthetic anabolic steroid methyltestosterone (MT) as growth promoter is prohibited in China. Validations of analytical methods for MT residue in food and the results obtained have become indispensable. The high performance liquid chromatography (HPLC) method for the detection of MT with liquid-liquid extraction by trichloromethanemethanol in carp muscle tissue was preliminarily validated with reference to the following parameters: recovery (accuracy)at the 1, 5 and 10 mgkg-1 level, between-run and within-run CV values (repeatability, also called relative standard deviation(RSD)) and limit of detection. The recoveries were above 80% and the between-run and within-run CV values below 10%for muscle tissue. The limit of detection was 0.05 mgkg-1.

  10. Model of Market Orientation of High-Tech Firms in Germany: Validation Study

    Directory of Open Access Journals (Sweden)

    Patrik Jangl

    2016-09-01

    Full Text Available The aim of this validation study was to verify a four-factor model of market orientation on a sample of German high-tech companies in the manufacturing industry. A modified version of the measuring scale (MMOS, composed of twelve items, was used for measurement. The target group consisted of business and marketing managers (N = 374 who recorded their answers on a seven-point Likert scale. The main methods used to achieve the objectives were exploratory and confirmatory factor analyses. Having verified the psychometric properties of the instrument, I proceeded to confirm the hypothesis of a four-factor solution model. Reliability and validity of the measuring instrument was also examined, which allowed a confirmation of the second hypothesis. The research may serve as the evidence of the instrument suitability for measuring market orientation in European cultural conditions. To obtain results from other sectors, the author recommends further research replication using the MMOS instrument.

  11. Convergent evolution as natural experiment: the tape of life reconsidered.

    Science.gov (United States)

    Powell, Russell; Mariscal, Carlos

    2015-12-06

    Stephen Jay Gould argued that replaying the 'tape of life' would result in radically different evolutionary outcomes. Recently, biologists and philosophers of science have paid increasing attention to the theoretical importance of convergent evolution-the independent origination of similar biological forms and functions-which many interpret as evidence against Gould's thesis. In this paper, we examine the evidentiary relevance of convergent evolution for the radical contingency debate. We show that under the right conditions, episodes of convergent evolution can constitute valid natural experiments that support inferences regarding the deep counterfactual stability of macroevolutionary outcomes. However, we argue that proponents of convergence have problematically lumped causally heterogeneous phenomena into a single evidentiary basket, in effect treating all convergent events as if they are of equivalent theoretical import. As a result, the 'critique from convergent evolution' fails to engage with key claims of the radical contingency thesis. To remedy this, we develop ways to break down the heterogeneous set of convergent events based on the nature of the generalizations they support. Adopting this more nuanced approach to convergent evolution allows us to differentiate iterated evolutionary outcomes that are probably common among alternative evolutionary histories and subject to law-like generalizations, from those that do little to undermine and may even support, the Gouldian view of life.

  12. Approaches to experimental validation of high-temperature gas-cooled reactor components

    Energy Technology Data Exchange (ETDEWEB)

    Belov, S.E. [Joint Stock Company ' Afrikantov OKB Mechanical Engineering' , Burnakovsky Proezd, 15, Nizhny Novgorod 603074 (Russian Federation); Borovkov, M.N., E-mail: borovkov@okbm.nnov.ru [Joint Stock Company ' Afrikantov OKB Mechanical Engineering' , Burnakovsky Proezd, 15, Nizhny Novgorod 603074 (Russian Federation); Golovko, V.F.; Dmitrieva, I.V.; Drumov, I.V.; Znamensky, D.S.; Kodochigov, N.G. [Joint Stock Company ' Afrikantov OKB Mechanical Engineering' , Burnakovsky Proezd, 15, Nizhny Novgorod 603074 (Russian Federation); Baxi, C.B.; Shenoy, A.; Telengator, A. [General Atomics, 3550 General Atomics Court, CA (United States); Razvi, J., E-mail: Junaid.Razvi@ga.com [General Atomics, 3550 General Atomics Court, CA (United States)

    2012-10-15

    Highlights: Black-Right-Pointing-Pointer Computational and experimental investigations of thermal and hydrodynamic characteristics for the equipment. Black-Right-Pointing-Pointer Vibroacoustic investigations. Black-Right-Pointing-Pointer Studies of the electromagnetic suspension system on GT-MHR turbo machine rotor models. Black-Right-Pointing-Pointer Experimental investigations of the catcher bearings design. - Abstract: The special feature of high-temperature gas-cooled reactors (HTGRs) is stressed operating conditions for equipment due to high temperature of the primary circuit helium, up to 950 Degree-Sign C, as well as acoustic and hydrodynamic loads upon the gas path elements. Therefore, great significance is given to reproduction of real operation conditions in tests. Experimental investigation of full-size nuclear power plant (NPP) primary circuit components is not practically feasible because costly test facilities will have to be developed for the power of up to hundreds of megawatts. Under such conditions, the only possible process to validate designs under development is representative tests of smaller scale models and fragmentary models. At the same time, in order to take in to validated account the effect of various physical factors, it is necessary to ensure reproduction of both individual processes and integrated tests incorporating needed integrated investigations. Presented are approaches to experimental validation of thermohydraulic and vibroacoustic characteristics for main equipment components and primary circuit path elements under standard loading conditions, which take account of their operation in the HTGR. Within the framework of the of modular helium reactor project, including a turbo machine in the primary circuit, a new and difficult problem is creation of multiple-bearing flexible vertical rotor. Presented are approaches to analytical and experimental validation of the rotor electromagnetic bearings, catcher bearings, flexible rotor

  13. Neural networks convergence using physicochemical data.

    Science.gov (United States)

    Karelson, Mati; Dobchev, Dimitar A; Kulshyn, Oleksandr V; Katritzky, Alan R

    2006-01-01

    An investigation of the neural network convergence and prediction based on three optimization algorithms, namely, Levenberg-Marquardt, conjugate gradient, and delta rule, is described. Several simulated neural networks built using the above three algorithms indicated that the Levenberg-Marquardt optimizer implemented as a back-propagation neural network converged faster than the other two algorithms and provides in most of the cases better prediction. These conclusions are based on eight physicochemical data sets, each with a significant number of compounds comparable to that usually used in the QSAR/QSPR modeling. The superiority of the Levenberg-Marquardt algorithm is revealed in terms of functional dependence of the change of the neural network weights with respect to the gradient of the error propagation as well as distribution of the weight values. The prediction of the models is assessed by the error of the validation sets not used in the training process.

  14. Service Creation and Deployment in Converged Networks

    DEFF Research Database (Denmark)

    Soler, José

    This monograph (Early Experiences related to Service Creation & Deployment in Converged Networks) presents different experiences related to architectures and mechanisms for deployment of telephony services, understood as especial features complementing the basic voice service. The context...... for these experiences is the transition of telecommunication (telephony) networks from circuit switched based systems towards packet based ones. The text of this monograph proceeds, unaltered for the most, from the author’s PhD thesis “Framework for Deployment of Advanced Telecommunication Services in Current...... and Future Converged Networks”, carried out at the Technical University of Denmark in the period [April 2002-April 2005]. Even though the technologies presented in the text have evolved from that period until now, the presented scenarios and setups are still valid as interesting initial steps in the realm....

  15. The Convergence in Spatial Tasks

    OpenAIRE

    Vladimir P. Kulagin; Victor Y. Tsvetkov; Maiya V. Maksimova

    2013-01-01

    The article reveals the problem of convergence of direct and inverse problems in Earth Sciences, describes the features and application of these problems, discloses analytical features of direct and inverse problems. The convergence criteria and conditions for convergence were presented. This work is supported by the Grant of the Government of the Russian Federation for support of scientific research, implemented under the supervision of leading scientists in Russian institutions of higher ed...

  16. Quantum Molecular Dynamics Validation of Nanocarbon Synthesis by High-Temperature Oxidation of Nanoparticles

    Science.gov (United States)

    Sheng, Chunyang; Nomura, Kenichi; Kalia, Rajiv; Nakano, Aiichiro; Shimamura, Kohei; Shimojo, Fuyuki; Vashishta, Priya; Department of Physics, Kumamoto University Collaboration; CACS USC Collaboration

    High-temperature oxidation of silicon-carbide nanoparticles (nSiC) underlies a wide range of technologies from high-power electronic switches for efficient electrical grid, thermal protection of space vehicles, to self-healing ceramic nanocomposites. Here, multimillion-atom reactive molecular dynamics simulations validated by ab initio quantum molecular dynamics simulations predict unexpected condensation of large graphene flakes during high-temperature oxidation of nSiC. In the validation process Small nSiC in oxygen environment is chosen to perform QMD simulation, then the QMD results provide the number of Si-O and C-O bonds as a function of time and high temperature, Same RMD simulation is simultaneously performed. We compare the time evolution of different bonds, and observe the condensation of large number of C-cluster nuclei into larger carbon clusters. We further provide the QMD simulation results as an input to a genetic algorithm, which trains the RMD force field parameters, the output force field produce results that are closer to the ground truth QMD simulation results. This research was supported by the Department of Energy (DOE).

  17. Professional convergence in forensic practice.

    Science.gov (United States)

    Mercer, D; Mason, T; Richman, J

    2001-06-01

    This paper outlines the development and convergence of forensic science and secure psychiatric services in the UK, locating the professionalization of forensic nursing within a complex web of political, economic, and ideological structures. It is suggested that a stagnation of the therapeutic enterprise in high and medium security provision has witnessed an intrusion of medical power into the societal body. Expanding technologies of control and surveillance are discussed in relation to the move from modernity to postmodernity and the ongoing dynamic of medicalized offending. Four aspects of globalization are identified as impacting upon the organization and application of forensic practice: (i) organized capitalism and the exhaustion of the welfare state; (ii) security versus danger and trust versus risk; (iii) science as a meta-language; and (iv) foreclosure as a mechanism of censorship. Finally, as a challenge for the profession, some predictions are offered about the future directions or demise of forensic nursing.

  18. Convergence of coupled cluster perturbation theory

    CERN Document Server

    Eriksen, Janus Juul; Matthews, Devin A; Jørgensen, Poul; Olsen, Jeppe

    2016-01-01

    The convergence of a recently proposed coupled cluster (CC) family of perturbation series [Eriksen et al., J. Chem. Phys. 140, 064108 (2014)], in which the energetic difference between a parent and a target CC model is expanded in orders of the M{\\o}ller-Plesset (MP) fluctuation potential, is investigated for four prototypical closed-shell systems (Ne, singlet methylene, distorted HF, and the fluoride anion) in standard and augmented basis sets. In these investigations, energy corrections of the various series have been calculated to high orders and their convergence radii determined by probing for possible front- and back-door intruder states. In summary, we conclude how it is primarily the choice of target state, and not the choice of parent state, which ultimately governs the convergence behavior of a given series. For example, restricting the target state to, say, triple or quadruple excitations might remove intruders present in series that target the full configuration interaction (FCI) limit, such as th...

  19. PowerShades II. Optimisation and validation of highly transparent photovoltaic. Final report

    Energy Technology Data Exchange (ETDEWEB)

    2010-07-15

    The objective of the project is continued development and validation of a novel Danish photovoltaic product with the work title ''PowerShade''. The PowerShade insulating glazing unit (IGU) is a combination of a strong solar shading device and a power producing photovoltaic coating. The core technology in the PowerShade IGU is a thin film silicon photovoltaic generator applied to a micro structured substrate. The geometry of the substrate provides the unique combination of properties that characterizes the PowerShade module - strong progressive shading, high transparency, and higher electrical output than other semitransparent photovoltaic products with similar transparencies. The project activities fall in two categories, namely development of the processing/product and validation of the product properties. The development part of the project is focussed on increasing the efficiency of the photovoltaic generator by changing from a single-stack type cell to a tandem-stack type cell. The inclusion of PowerShade cells in insulating glazing (IG) units is also addressed in this project. The validation part of the project aims at validation of stability, thermal and optical properties as well as validation of the electrical yield of the product. The validation of thermal and optical properties has been done using full size modules installed in a test facility built during the 2006-08 ''PowerShades'' project. The achieved results will be vital in the coming realisation of a commercial product. Initial processing steps have been automated, and more efficient tandem-type solar cells have been developed. A damp heat test of an IGU has been carried out without any degradation of the solar cell. The PowerShade module assembly concept has been further developed and discussed with different automation equipment vendors and a pick-and-place tool developed. PowerShade's influence on the indoor climate has been modelled and verified by

  20. Regional disparities and convergences in Asia

    Directory of Open Access Journals (Sweden)

    Petr Blížkovský

    2012-01-01

    Full Text Available This paper analyses the disparity and convergence between the 10 and 11 countries of ASEAN and the Commonwealth of Independent States (CIS respectively and the 31 sub-national regions (provinces in China.The regional disparity levels and trends were analysed using the Gini coefficient between the regions (nominal GDP, GDP per capita and GDP per capita in Purchasing Parity Power, PPP. The convergence analysis was evaluated using the Disparity Range Coefficient (DRC, the Average Disparity Range Coefficient (ADRC, and the σ- and b-convergence. The time period covered was 2000–2008 (ASEAN and CIS and 2000–2006 (China.The results show a relatively high regional disparity between the Asian macro-regions of ASEAN and CIS and much lower disparities between the China sub-regions. The disparities were highest if based on the nominal GDP and lower if based on the DGP per capita. The GDP per capita was lower, between 0.30 to 0.4 for the CIS and China, and around 0.7 in ASEAN. The convergence analysis showed mixed results. Based on the DRC analysis, none of the Asian macro-regions converged. All three macro-regions diverged 1.4 to 12.68 times quicker than the average macro-regional GDP per capita grew, ASEAN being at the divergence top and China at the bottom. Based on the ADRC analysis, all macro-regions also proved to diverge. However, the divergence rates were much lower. For macro-regions China and CIS, the divergence was slower than macro-regional growth, thus their divergence was moderate. On the other side, if the macro-region was calculated using the σ-convergence analysis, the converging macro-regions were ASEAN and China, with 2.13% and 0.47% respectively. CIS was diverging at the speed of 1.25% per year. Based on b-convergence, ASEAN and China were converging (1.54% and 1.32%, and a slow divergence trend was registered for CIS, 1.01%.

  1. Validation of a technique by high-performance liquid chromatography for the determination of total isoflavones

    Directory of Open Access Journals (Sweden)

    Pilar A. Soledispa Cañarte

    2017-04-01

    Full Text Available Context: Isoflavones may act as selective regulators in the prevention of various diseases. The most important source of isoflavones is the soy, from which different phytotherapeutics are elaborated of use in Ecuadorian population. However, its concentration varies depending on several factors, therefore quality assessment need to be carried out through out several analytical methods. Aims: To validate an analytical method by high precision liquid chromatography (HPLC to quantify total isoflavones in herbal medicine. Methods: To quantify isoflavones, it was used a brand liquid chromatography with UV/VIS detector at 260 nm, C-18 column using isocratic method. The mobile phase was composed of 2% acetic acid: acetonitrile (75:25. The quantification was performed against reference standard. The parameters for the validation followed the established in the USP 33. Results: The chromatogram presented six peaks with elution between 1.557 and 18.913 min. The linearity of the system and the method got r2 equal to 0.98 and 0.99 respectively. The coefficients of variation 1.5% in the study of repetitiveness and 2% in intermediate precision. The accuracy of the adjusted lineal model exhibited r=0.95 and intercept reliable interval (-0.921; 1.743. Conclusions: The validated method was specific, accurate, precise and linear. It can be used for quality control and stability studies of isoflavones present in herbal medicine.

  2. Automated face analysis by feature point tracking has high concurrent validity with manual FACS coding.

    Science.gov (United States)

    Cohn, J F; Zlochower, A J; Lien, J; Kanade, T

    1999-01-01

    The face is a rich source of information about human behavior. Available methods for coding facial displays, however, are human-observer dependent, labor intensive, and difficult to standardize. To enable rigorous and efficient quantitative measurement of facial displays, we have developed an automated method of facial display analysis. In this report, we compare the results with this automated system with those of manual FACS (Facial Action Coding System, Ekman & Friesen, 1978a) coding. One hundred university students were videotaped while performing a series of facial displays. The image sequences were coded from videotape by certified FACS coders. Fifteen action units and action unit combinations that occurred a minimum of 25 times were selected for automated analysis. Facial features were automatically tracked in digitized image sequences using a hierarchical algorithm for estimating optical flow. The measurements were normalized for variation in position, orientation, and scale. The image sequences were randomly divided into a training set and a cross-validation set, and discriminant function analyses were conducted on the feature point measurements. In the training set, average agreement with manual FACS coding was 92% or higher for action units in the brow, eye, and mouth regions. In the cross-validation set, average agreement was 91%, 88%, and 81% for action units in the brow, eye, and mouth regions, respectively. Automated face analysis by feature point tracking demonstrated high concurrent validity with manual FACS coding.

  3. Development and validation of a high throughput system for discovery of antigens for autoantibody detection.

    Directory of Open Access Journals (Sweden)

    Isabel K Macdonald

    Full Text Available An assay employing a panel of tumor-associated antigens has been validated and is available commercially (EarlyCDT®-Lung to aid the early detection of lung cancer by measurement of serum autoantibodies. The high throughput (HTP strategy described herein was pursued to identify new antigens to add to the EarlyCDT-Lung panel and to assist in the development of new panels for other cancers. Two ligation-independent cloning vectors were designed and synthesized, producing fusion proteins suitable for the autoantibody ELISA. We developed an abridged HTP version of the validated autoantibody ELISA, determining that results reflected the performance of the EarlyCDT assay, by comparing results on both formats. Once validated this HTP ELISA was utilized to screen multiple fusion proteins prepared on small-scale, by a HTP expression screen. We determined whether the assay performance for these HTP protein batches was an accurate reflection of the performance of R&D or commercial batches. A HTP discovery platform for the identification and optimal production of tumor-associated antigens which detects autoantibodies has been developed and validated. The most favorable conditions for the exposure of immunogenic epitopes were assessed to produce discriminatory proteins for use in a commercial ELISA. This process is rapid and cost-effective compared to standard cloning and screening technologies and enables rapid advancement in the field of autoantibody assay discovery. This approach will significantly reduce timescale and costs for developing similar panels of autoantibody assays for the detection of other cancer types with the ultimate aim of improved overall survival due to early diagnosis and treatment.

  4. Validation of the Performance of High-level Waste Disposal System

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Won Jin; Park, J. H.; Lee, J. O. (and others)

    2007-06-15

    The experimental researches to validate the integrity and safety of high-level waste disposal system were carried out. The studies on the construction of KURT, and the site rock characteristics were conducted. Thermal-hydro-mechanical behavior of engineered barrier system was investigated using the engineering-scale test facility. The migration and retardation of radionuclide through the rock fracture under anaerobic and reducing condition were studied. The distribution coefficients of radionuclides onto granite, the rock matrix diffusion coefficients, and the gap and grain boundary inventories of spent fuel were measured.

  5. A high confidence, manually validated human blood plasma protein reference set

    DEFF Research Database (Denmark)

    Schenk, Susann; Schoenhals, Gary J; de Souza, Gustavo

    2008-01-01

    sources, including the HUPO PPP dataset. CONCLUSION: Superior instrumentation combined with rigorous validation criteria gave rise to a set of 697 plasma proteins in which we have very high confidence, demonstrated by an exceptionally low false peptide identification rate of 0.29%.......BACKGROUND: The immense diagnostic potential of human plasma has prompted great interest and effort in cataloging its contents, exemplified by the Human Proteome Organization (HUPO) Plasma Proteome Project (PPP) pilot project. Due to challenges in obtaining a reliable blood plasma protein list...

  6. Validity of a Wearable Accelerometer Device to Measure Average Acceleration Values During High-Speed Running.

    Science.gov (United States)

    Alexander, Jeremy P; Hopkinson, Trent L; Wundersitz, Daniel W T; Serpell, Benjamin G; Mara, Jocelyn K; Ball, Nick B

    2016-11-01

    Alexander, JP, Hopkinson, TL, Wundersitz, DWT, Serpell, BG, Mara, JK, and Ball, NB. Validity of a wearable accelerometer device to measure average acceleration values during high-speed running. J Strength Cond Res 30(11): 3007-3013, 2016-The aim of this study was to determine the validity of an accelerometer to measure average acceleration values during high-speed running. Thirteen subjects performed three sprint efforts over a 40-m distance (n = 39). Acceleration was measured using a 100-Hz triaxial accelerometer integrated within a wearable tracking device (SPI-HPU; GPSports). To provide a concurrent measure of acceleration, timing gates were positioned at 10-m intervals (0-40 m). Accelerometer data collected during 0-10 m and 10-20 m provided a measure of average acceleration values. Accelerometer data was recorded as the raw output and filtered by applying a 3-point moving average and a 10-point moving average. The accelerometer could not measure average acceleration values during high-speed running. The accelerometer significantly overestimated average acceleration values during both 0-10 m and 10-20 m, regardless of the data filtering technique (p < 0.001). Body mass significantly affected all accelerometer variables (p < 0.10, partial η = 0.091-0.219). Body mass and the absence of a gravity compensation formula affect the accuracy and practicality of accelerometers. Until GPSports-integrated accelerometers incorporate a gravity compensation formula, the usefulness of any accelerometer-derived algorithms is questionable.

  7. Design and Validation of High Date Rate Ka-Band Software Defined Radio for Small Satellite

    Science.gov (United States)

    Xia, Tian

    2016-01-01

    The Design and Validation of High Date Rate Ka- Band Software Defined Radio for Small Satellite project will develop a novel Ka-band software defined radio (SDR) that is capable of establishing high data rate inter-satellite links with a throughput of 500 megabits per second (Mb/s) and providing millimeter ranging precision. The system will be designed to operate with high performance and reliability that is robust against various interference effects and network anomalies. The Ka-band radio resulting from this work will improve upon state of the art Ka-band radios in terms of dimensional size, mass and power dissipation, which limit their use in small satellites.

  8. Flight validation of ground-based assessment for control power requirements at high angles of attack

    Science.gov (United States)

    Ogburn, Marilyn E.; Ross, Holly M.; Foster, John V.; Pahle, Joseph W.; Sternberg, Charles A.; Traven, Ricardo; Lackey, James B.; Abbott, Troy D.

    1994-01-01

    A review is presented in viewgraph format of an ongoing NASA/U.S. Navy study to determine control power requirements at high angles of attack for the next generation high-performance aircraft. This paper focuses on recent flight test activities using the NASA High Alpha Research Vehicle (HARV), which are intended to validate results of previous ground-based simulation studies. The purpose of this study is discussed, and the overall program structure, approach, and objectives are described. Results from two areas of investigation are presented: (1) nose-down control power requirements and (2) lateral-directional control power requirements. Selected results which illustrate issues and challenges that are being addressed in the study are discussed including test methodology, comparisons between simulation and flight, and general lessons learned.

  9. Evidências de validade convergente do SON-R 2½-7[a] com o WPPSI-III e WISC-III Evidences of convergent validity of SON-R 2½-7[a] with WPPSI-III and WISC-III

    Directory of Open Access Journals (Sweden)

    Camila Akemi Karino

    2011-01-01

    Full Text Available Um processo de validação adequado é fundamental para assegurar uma interpretação correta dos resultados de um teste. Assim, este estudo investigou a validade convergente do teste não-verbal de inteligência SON-R 2½-7[a] com o WPPSI-III e o WISC-III. O teste é a versão abreviada do SON-R 2½-7, de origem holandesa, normatizado e validado em vários países da Europa. No total, 109 crianças de três estados brasileiros participaram do estudo. A correlação entre o SON-R 2½-7[a] e o WPPSI-III foi igual a 0,75 e com o WISC-III foi de 0,69. Esses coeficientes de validade são muito semelhantes aos encontrados em estudos feitos com o SON-R 2½-7 em outros países. Conclui-se que os resultados indicam uma validade convergente satisfatória do teste SON-R 2½-7[a].An adequate validation process is fundamental to ensure sound interpretations of test results. Thus, this study aimed to investigate the convergent validity of the SON-R 2½-7[a] with the WPPSI-III and the WISC-III. The test is an abridged edition of the SON-R 2½-7, a Dutch non-verbal intelligence test, with normatization and validation studies done in several European countries. A total of 109 children from three Brazilian states participated in the study. The correlations of the SON-R 2½-7[a] with the WPPSI-III and with the WISC-III were .75 and .69, respectively. The validation coefficients encountered are very similar to the ones found in studies with the SON-R 2½-7 in other countries. The results imply a satisfactory convergent validity of the SON-R 2½-7[a].

  10. NASA LaRC airborne high spectral resolution lidar aerosol measurements during MILAGRO: observations and validation

    Directory of Open Access Journals (Sweden)

    L. I. Kleinman

    2009-07-01

    Full Text Available The NASA Langley Research Center (LaRC airborne High Spectral Resolution Lidar (HSRL measures vertical profiles of aerosol extinction, backscatter, and depolarization at both 532 nm and 1064 nm. In March of 2006 the HSRL participated in the Megacity Initiative: Local and Global Research Observations (MILAGRO campaign along with several other suites of instruments deployed on both aircraft and ground based platforms. This paper presents high spatial and vertical resolution HSRL measurements of aerosol extinction and optical depth from MILAGRO and comparisons of those measurements with similar measurements from other sensors and model predictions. HSRL measurements coincident with airborne in situ aerosol scattering and absorption measurements from two different instrument suites on the C-130 and G-1 aircraft, airborne aerosol optical depth (AOD and extinction measurements from an airborne tracking sunphotometer on the J-31 aircraft, and AOD from a network of ground based Aerosol Robotic Network (AERONET sun photometers are presented as a validation of the HSRL aerosol extinction and optical depth products. Regarding the extinction validation, we find bias differences between HSRL and these instruments to be less than 3% (0.01 km−1 at 532 nm, the wavelength at which the HSRL technique is employed. The rms differences at 532 nm were less than 50% (0.015 km−1. To our knowledge this is the most comprehensive validation of the HSRL measurement of aerosol extinction and optical depth to date. The observed bias differences in ambient aerosol extinction between HSRL and other measurements is within 15–20% at visible wavelengths, found by previous studies to be the differences observed with current state-of-the-art instrumentation (Schmid et al., 2006.

  11. NASA LaRC airborne high spectral resolution lidar aerosol measurements during MILAGRO: observations and validation

    Directory of Open Access Journals (Sweden)

    R. R. Rogers

    2009-04-01

    Full Text Available The NASA Langley Research Center (LaRC airborne High Spectral Resolution Lidar (HSRL measures vertical profiles of aerosol extinction, backscatter, and depolarization at both 532 nm and 1064 nm. In March of 2006 the HSRL participated in the Megacity Initiative: Local and Global Research Observations (MILAGRO campaign along with several other suites of instruments deployed on both aircraft and ground based platforms. This paper presents high spatial and vertical resolution HSRL measurements of aerosol extinction and optical depth from MILAGRO and comparisons of those measurements with similar measurements from other sensors and model predictions. HSRL measurements coincident with airborne in situ aerosol scattering and absorption measurements from two different instrument suites on the C-130 and G-1 aircraft, airborne aerosol optical depth (AOD and extinction measurements from an airborne tracking sunphotometer on the J-31 aircraft, and AOD from a network of ground based Aerosol Robotic Network (AERONET sun photometers are presented as a validation of the HSRL aerosol extinction and optical depth products. Regarding the extinction validation, we find bias differences between HSRL and these instruments to be less than 3% (0.01 km−1 at 532 nm, the wavelength at which the HSRL technique is employed. The rms differences at 532 nm were less than 50% (0.015 km−1. To our knowledge this is the most comprehensive validation of the HSRL measurement of aerosol extinction and optical depth to date. The observed bias differences in ambient aerosol extinction between HSRL and other measurements is within 15–20% at visible wavelengths, found by previous studies to be the differences observed with current state-of-the-art instrumentation (Schmid et al., 2006.

  12. Notes on Some Convergences in Riesz Space

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhi-jie; AI Fu-ju

    2007-01-01

    An equivalent description of u-uniform convergence is presented first. Then the relations among the order convergence,u-uniform convergence and norm convergence of sequences are discussed in Riesz spaces. An equivalence of the three convergences is brought forward; namely, {fn} is a u-uniform Cauchy sequence. Finally the relations among the three convergences of sequences am also extended to the relations among the convergences of nets in Riesz spaces.

  13. High-definition fiber tractography of the human brain: neuroanatomical validation and neurosurgical applications.

    Science.gov (United States)

    Fernandez-Miranda, Juan C; Pathak, Sudhir; Engh, Johnathan; Jarbo, Kevin; Verstynen, Timothy; Yeh, Fang-Cheng; Wang, Yibao; Mintz, Arlan; Boada, Fernando; Schneider, Walter; Friedlander, Robert

    2012-08-01

    High-definition fiber tracking (HDFT) is a novel combination of processing, reconstruction, and tractography methods that can track white matter fibers from cortex, through complex fiber crossings, to cortical and subcortical targets with subvoxel resolution. To perform neuroanatomical validation of HDFT and to investigate its neurosurgical applications. Six neurologically healthy adults and 36 patients with brain lesions were studied. Diffusion spectrum imaging data were reconstructed with a Generalized Q-Ball Imaging approach. Fiber dissection studies were performed in 20 human brains, and selected dissection results were compared with tractography. HDFT provides accurate replication of known neuroanatomical features such as the gyral and sulcal folding patterns, the characteristic shape of the claustrum, the segmentation of the thalamic nuclei, the decussation of the superior cerebellar peduncle, the multiple fiber crossing at the centrum semiovale, the complex angulation of the optic radiations, the terminal arborization of the arcuate tract, and the cortical segmentation of the dorsal Broca area. From a clinical perspective, we show that HDFT provides accurate structural connectivity studies in patients with intracerebral lesions, allowing qualitative and quantitative white matter damage assessment, aiding in understanding lesional patterns of white matter structural injury, and facilitating innovative neurosurgical applications. High-grade gliomas produce significant disruption of fibers, and low-grade gliomas cause fiber displacement. Cavernomas cause both displacement and disruption of fibers. Our HDFT approach provides an accurate reconstruction of white matter fiber tracts with unprecedented detail in both the normal and pathological human brain. Further studies to validate the clinical findings are needed.

  14. Stochastic Engine Convergence Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Glaser, R

    2001-12-11

    ;'burn-in'' period. The MCMC process begins at a particular state, which is selected at random or by design, according to the wish of the user of the engine. After the burn-in period, the chain has essentially forgotten where it started. Moreover, the sample x{sup (t{sub 0})}, x{sup (T{sub 0}+1)},... can be used for most purposes as a random sample from f, even though the x{sup (T{sub 0}+t)}, because of Markovian dependency, are not independent. For example, averages involving x{sup (t{sub 0})}, x{sup (t{sub 0}+1)},... may have an approximate normal distribution. The purpose of this note is to discuss the monitoring techniques currently in place in the stochastic engine software that addresses the issues of burn-in, stationarity, and normality. They are loosely termed ''convergence diagnostics'', in reference to the underlying Markov chains, which converge asymptotically to the desired posterior distribution.

  15. Reliability and validity of academic motivation scale for sports high school students’

    Directory of Open Access Journals (Sweden)

    Haslofça Fehime

    2016-01-01

    Full Text Available This study was designed to test validity and reliability of Academic Motivation Scale (AMS for sports high school students. The research conducted with 357 volunteered girls (n=117 and boys (n=240. Confirmatory factor analysis showed that Chi square (χ2, degrees of freedom (df and χ2/df ratio were 1102.90, 341 and 3.234, respectively. Goodness of Fit Index, Comparative Fit Index, Non-normed Fit Index and Incremental Fit Index were between 0.92-0.95. Additionally, Adjusted Goodness of Fit Index, An Average Errors Square Root and Root Mean Square Error of Approximation were 0.88, 0.070 and 0.079, respectively. Subscale reliability coefficients were between 0.77 and 0.86. Test-retest correlations of AMS were found between 0.79 and 0.91. Results showed that scale was suitable for determination of sports high school students’ academicals motivation levels.

  16. Construction and validation of two metagenomic DNA libraries from Cerrado soil with high clay content.

    Science.gov (United States)

    de Castro, Alinne Pereira; Quirino, Betania Ferraz; Allen, Heather; Williamson, Lynn L; Handelsman, Jo; Krüger, Ricardo Henrique

    2011-11-01

    A challenge of metagenomic studies is in the extraction and purification of DNA from environmental samples. The soils of the Cerrado region of Brazil present several technical difficulties to DNA extraction: high clay content (>55% w/w), low pH (4.7) and high iron levels (146 ppm). Here we describe for the first time the efficient recovery and purification of microbial DNA associated with these unusual soil characteristics and the construction and validation of two metagenomic libraries: a 150,000 clones library with insert size of approximately 8 kb and a 65,000 clones library with insert size of approximately 35 kb. The construction of these metagenomic libraries will allow the biotechnological exploitation of the microbial community present in the soil from this endangered biome.

  17. Design and validation of the high performance and low noise CQU-DTU-LN1 airfoils

    DEFF Research Database (Denmark)

    Cheng, Jiangtao; Zhu, Wei Jun; Fischer, Andreas

    2014-01-01

    with the blade element momentum theory, the viscous-inviscid XFOIL code and an airfoil self-noise prediction model, an optimization algorithm has been developed for designing the high performance and low noise CQU-DTU-LN1 series of airfoils with targets of maximum power coefficient and low noise emission......This paper presents the design and validation of the high performance and low noise Chong Qing University and Technical University of Denmark LN1 (CQU-DTU-LN1) series of airfoils for wind turbine applications. The new design method uses target characteristics of wind turbine airfoils in the design...... emission between the CQU-DTU-LN118 airfoil and the National Advisory Committee for Aeronautics (NACA) 64618 airfoil, which is used in modern wind turbine blades, are carried out. Copyright © 2013 John Wiley & Sons, Ltd....

  18. Adaptation and validation of DNA synthesis detection by fluorescent dye derivatization for high-throughput screening.

    Science.gov (United States)

    Ranall, Max V; Gabrielli, Brian G; Gonda, Thomas J

    2010-05-01

    Cellular proliferation is fundamental to organism development, tissue renewal, and diverse disease states such as cancer. In vitro measurement of proliferation by high-throughput screening allows rapid characterization of the effects of small-molecule or genetic treatments on primary and established cell lines. Current assays that directly measure the cell cycle are not amenable to high-throughput processing and analysis. Here we report the adaptation of the chemical method for detecting DNA synthesis by 5-ethynyl-2'-deoxyuridine (EdU) incorporation into both high-throughput liquid handling and high-content imaging analysis. We demonstrate that chemical detection of EdU incorporation is effective for high-resolution analysis and quantitation of DNA synthesis by high-content imaging. To validate this assay platform we used treatments of MCF10A cells with media supplements and pharmacological inhibitors that are known to affect cell proliferation. Treatments with specific kinase inhibitors indicate that EGF and serum stimulation employs both the mitogen extracellular kinase (MEK)/extracellular-regulated kinase (ERK) and phosphoinositol-3 kinase (PI3K)/AKT signaling networks. As described here, this method is fast, reliable, and inexpensive and yields robust data that can be easily interpreted.

  19. The Convergence of Intelligences

    Science.gov (United States)

    Diederich, Joachim

    Minsky (1985) argued an extraterrestrial intelligence may be similar to ours despite very different origins. ``Problem- solving'' offers evolutionary advantages and individuals who are part of a technical civilisation should have this capacity. On earth, the principles of problem-solving are the same for humans, some primates and machines based on Artificial Intelligence (AI) techniques. Intelligent systems use ``goals'' and ``sub-goals'' for problem-solving, with memories and representations of ``objects'' and ``sub-objects'' as well as knowledge of relations such as ``cause'' or ``difference.'' Some of these objects are generic and cannot easily be divided into parts. We must, therefore, assume that these objects and relations are universal, and a general property of intelligence. Minsky's arguments from 1985 are extended here. The last decade has seen the development of a general learning theory (``computational learning theory'' (CLT) or ``statistical learning theory'') which equally applies to humans, animals and machines. It is argued that basic learning laws will also apply to an evolved alien intelligence, and this includes limitations of what can be learned efficiently. An example from CLT is that the general learning problem for neural networks is intractable, i.e. it cannot be solved efficiently for all instances (it is ``NP-complete''). It is the objective of this paper to show that evolved intelligences will be constrained by general learning laws and will use task-decomposition for problem-solving. Since learning and problem-solving are core features of intelligence, it can be said that intelligences converge despite very different origins.

  20. CONVERGENCE OF TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    R. Siriram

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Technology is a catalyst for competitive advantage. However, it is how technology is used that leads to a firm’s improved performance. In this article, an investigative framework is constructed to understand better what strategically drives new technology adoption. The strategic drivers include technology and business strategy alignment, better technology planning and selection of new technologies, the effects on a firm’s culture and climate, links to a firm’s organisational and environmental evolution, and benefits through convergence and collaboration. Using an investigative framework, it is shown how the strategic drivers link to improve a firm’s performance, producing competitive advantage. The investigative framework is tested using structural equation modelling. Various hypotheses are formed, and recommendations for further research are made.

    AFRIKAANSE OPSOMMING: Tegnologie is ‘n katalisator vir mededingende voordeel. Dit is egter hoe tegnologie aangewend word wat aanleiding gee tot ‘n onderneming se verbeterde prestasie. In hierdie artikel word ‘n ondersoekende raamwerk gekonstrueer om insig te kry in dit wat die aanvaarding van nuwe tegnologie strategies dryf. Die strategiese dryfvere sluit in die belyning van tegnologie en ondernemingstrategie, beter tegnologiebeplanning en seleksie van nuwe tegnologieë, die effek op ‘n onderneming se kultuur en klimaat, koppeling na ‘n onderneming se organisatoriese en omgewingsevolusie, en voordele verkry deur konvergensie en samewerking. Deur ‘n ondersoekende raamwerk te gebruik, word daar getoon dat die strategiese dryfvere koppel om ‘n onderneming se prestasie te verbeter en sodoende ‘n mededingende voordeel te skep. Die raamwerk word getoets en hipoteses geformuleer waarna aanbevelings oor verdere navorsing aan die hand gedoen word.

  1. Sensitivity Analysis and Statistical Convergence of a Saltating Particle Model

    CERN Document Server

    Maldonado, S

    2016-01-01

    Saltation models provide considerable insight into near-bed sediment transport. This paper outlines a simple, efficient numerical model of stochastic saltation, which is validated against previously published experimental data on saltation in a channel of nearly horizontal bed. Convergence tests are systematically applied to ensure the model is free from statistical errors emanating from the number of particle hops considered. Two criteria for statistical convergence are derived; according to the first criterion, at least $10^3$ hops appear to be necessary for convergent results, whereas $10^4$ saltations seem to be the minimum required in order to achieve statistical convergence in accordance with the second criterion. Two empirical formulae for lift force are considered: one dependent on the slip (relative) velocity of the particle multiplied by the vertical gradient of the horizontal flow velocity component; the other dependent on the difference between the squares of the slip velocity components at the to...

  2. Cross-Cultural Validation of the High Blood Pressure Health Literacy Scale in a Chinese Community.

    Directory of Open Access Journals (Sweden)

    Qinghua Zhang

    Full Text Available Considering the importance of health literacy (HL for the maximum yield from the hypertension control programs, development of a reliable and valid instrument of hypertension-related HL is critical. This study aimed to translate and validate the High Blood Pressure-Health Literacy Scale (HBP-HLS into Chinese (C-HBP-HLS and evaluate its psychometric properties in Chinese context.Between June 2013 and January 2014, a cross-sectional study was conducted among recruited hypertensive patients belonging to the Han and Kazakh-Chinese communities in Urumqi, Xinjiang, China.A pilot sample (n = 242 was selected for the exploratory factor analysis of the translated and modified instrument. Another sample (n = 308 was recruited for the confirmatory factor analysis. C-HBP-HLS consisted of five dimensions (Print Health Literacy, Medication Label, Understanding Ability, Newest Vital Sign Test, and Avoiding Food Allergy containing 15 items, accounting for 77.7% of the total variance. The 5-factor model demonstrated a good overall fit. The scale-level content validity index was 0.85. Cronbach's alpha of the overall scale was 0.78 and test-retest reliability was 0.96. Education level had a strong positive correlation with the scores for items Q1, Q2, and Q3(r = 0.481, 0.492, 0.475, respectively. Health Literacy scores among Kazakh patients were significantly lower than Han (7.13±7.90 vs. 30.10±13.42, Z = -14.573, P<0.001.C-HBP-HLS demonstrated suitable factor structure and robust psychometric properties for measuring health literacy level among hypertensive patients in China.

  3. Validation of a high performance liquid chromatography method for the stabilization of epigallocatechin gallate.

    Science.gov (United States)

    Fangueiro, Joana F; Parra, Alexander; Silva, Amélia M; Egea, Maria A; Souto, Eliana B; Garcia, Maria L; Calpena, Ana C

    2014-11-20

    Epigallocatechin gallate (EGCG) is a green tea catechin with potential health benefits, such as anti-oxidant, anti-carcinogenic and anti-inflammatory effects. In general, EGCG is highly susceptible to degradation, therefore presenting stability problems. The present paper was focused on the study of EGCG stability in HEPES (N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid) medium regarding the pH dependency, storage temperature and in the presence of ascorbic acid a reducing agent. The evaluation of EGCG in HEPES buffer has demonstrated that this molecule is not able of maintaining its physicochemical properties and potential beneficial effects, since it is partially or completely degraded, depending on the EGCG concentration. The storage temperature of EGCG most suitable to maintain its structure was shown to be the lower values (4 or -20 °C). The pH 3.5 was able to provide greater stability than pH 7.4. However, the presence of a reducing agent (i.e., ascorbic acid) was shown to provide greater protection against degradation of EGCG. A validation method based on RP-HPLC with UV-vis detection was carried out for two media: water and a biocompatible physiological medium composed of Transcutol®P, ethanol and ascorbic acid. The quantification of EGCG for purposes, using pure EGCG, requires a validated HPLC method which could be possible to apply in pharmacokinetic and pharmacodynamics studies.

  4. Simultaneous estimation of three triterpenoids from Carissa carandas using validated high performance liquid chromatography

    Directory of Open Access Journals (Sweden)

    Sunita Shailajan

    2012-01-01

    Full Text Available Background : Carissa carandas L. (Apocynaceae, an important fruit of tropical and subtropical arid region, has a great potential for the development of a new phytotherapeutic medicine. Due to an increase in commercial products of this fruit in the global market, an extensive phytochemical comparison seems imperative to understand its internal quality. Aims and Objective : To develop and validate an HPLC-DAD method for simultaneous estimation of three triterpenoids from C. carandas. Materials and Methods : A simple, sensitive and rapid HPLC-DAD method was developed for simultaneous estimation of lupeol, stigmasterol, and β-sitosterol from C. carandas fruits. Isocratic elution at a flow rate of 1.0 mL/min was employed on C 18 Cosmosil column with PDA detection at 210 nm using acetonitrile and ethanol. Different parts of C. carandas and its fruits collected from different geographical region were screened for lupeol, stigmasterol, and β-sitosterol contents. Results : Proposed method for simultaneous estimation of lupeol, stigmasterol and β-sitosterol was found highly specific, reliable, and sensitive which allowed good recovery of all analytes. It was validated as per ICH guidelines and proved to have good linearity, precision, repeatability, and stability. It was efficiently applied to screen different samples of C. carandas providing a mean to assess the quality and authenticity. Conclusion : The HPLC method could be an effective technique for routine analysis of lupeol, stigmasterol, and β-sitosterol simultaneously and monitoring the quality of fruit and its available products in cosmetic and pharmaceutical companies.

  5. A High-Content Assay for Biosensor Validation and for Examining Stimuli that Affect Biosensor Activity.

    Science.gov (United States)

    Slattery, Scott D; Hahn, Klaus M

    2014-12-01

    Biosensors are valuable tools used to monitor many different protein behaviors in vivo. Demand for new biosensors is high, but their development and characterization can be difficult. During biosensor design, it is necessary to evaluate the effects of different biosensor structures on specificity, brightness, and fluorescence responses. By co-expressing the biosensor with upstream proteins that either stimulate or inhibit the activity reported by the biosensor, one can determine the difference between the biosensor's maximally activated and inactivated state, and examine response to specific proteins. We describe here a method for biosensor validation in a 96-well plate format using an automated microscope. This protocol produces dose-response curves, enables efficient examination of many parameters, and unlike cell suspension assays, allows visual inspection (e.g., for cell health and biosensor or regulator localization). Optimization of single-chain and dual-chain Rho GTPase biosensors is addressed, but the assay is applicable to any biosensor that can be expressed or otherwise loaded in adherent cells. The assay can also be used for purposes other than biosensor validation, using a well-characterized biosensor as a readout for effects of upstream molecules.

  6. Psychometrics and life history strategy: the structure and validity of the High K Strategy Scale.

    Science.gov (United States)

    Copping, Lee T; Campbell, Anne; Muncer, Steven

    2014-03-22

    In this paper, we critically review the conceptualization and implementation of psychological measures of life history strategy associated with Differential K theory. The High K Strategy Scale (HKSS: Giosan, 2006) was distributed to a large British sample (n = 809) with the aim of assessing its factor structure and construct validity in relation to theoretically relevant life history variables: age of puberty, age of first sexual encounter, and number of sexual partners. Exploratory and confirmatory factor analyses indicated that the HKSS in its current form did not show an adequate statistical fit to the data. Modifications to improve fit indicated four correlated factors (personal capital, environmental stability, environmental security, and social capital). Later puberty in women was positively associated with measures of the environment and personal capital. Among men, contrary to Differential K predictions but in line with female mate preferences, earlier sexual debut and more sexual partners were positively associated with more favorable environments and higher personal and social capital. We raise concerns about the use of psychometric indicators of lifestyle and personality as proxies for life history strategy when they have not been validated against objective measures derived from contemporary life history theory and when their status as causes, mediators, or correlates has not been investigated.

  7. Validation of SCALE for High Temperature Gas-Cooled Reactors Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ilas, Germina [ORNL; Ilas, Dan [ORNL; Kelly, Ryan P [ORNL; Sunny, Eva E [ORNL

    2012-08-01

    This report documents verification and validation studies carried out to assess the performance of the SCALE code system methods and nuclear data for modeling and analysis of High Temperature Gas-Cooled Reactor (HTGR) configurations. Validation data were available from the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhE Handbook), prepared by the International Reactor Physics Experiment Evaluation Project, for two different HTGR designs: prismatic and pebble bed. SCALE models have been developed for HTTR, a prismatic fuel design reactor operated in Japan and HTR-10, a pebble bed reactor operated in China. The models were based on benchmark specifications included in the 2009, 2010, and 2011 releases of the IRPhE Handbook. SCALE models for the HTR-PROTEUS pebble bed configuration at the PROTEUS critical facility in Switzerland have also been developed, based on benchmark specifications included in a 2009 IRPhE draft benchmark. The development of the SCALE models has involved a series of investigations to identify particular issues associated with modeling the physics of HTGRs and to understand and quantify the effect of particular modeling assumptions on calculation-to-experiment comparisons.

  8. Development and Validation of Reversed-Phase High Performance Liquid Chromatographic Method for Hydroxychloroquine Sulphate.

    Science.gov (United States)

    Singh, A; Roopkishora; Singh, C L; Gupta, R; Kumar, S; Kumar, M

    2015-01-01

    In the present work new, simple reversed-phase high performance liquid chromatographic method was developed and validated for the determination of hydroxychloroquine sulphate in blood plasma. Chloroquine sulphate was used as an internal standard. The chromatographic separation was achieved with octadecyl silane Hypersil C18 column (250×6 mm, 5 μm) using water and organic (acetonitrile:methanol: 50:50, v/v) mobile phase in 75:25 v/v ratio, with sodium 1-pentanesulfonate and phosphoric acid. This organic phase was maintained at pH 3.0 by orthophosphoric acid. The flow rate of 2.0 ml/min(.) with detection at 343 nm was used in the analysis. The calibration curve of standard hydroxychloroquine sulphate was linear in range 0.1-20.0 μg/ml. The method was validated with respected to linearity, range, precision, accuracy, specificity and robustness studies according to ICH guidelines. The method was found to be accurate and robust to analyze the hydroxychloroquine sulphate in plasma samples.

  9. Development and validation of high performance liquid chromatographic method for analysis of clozapine.

    Science.gov (United States)

    Kaur, Harpreet; Bassi, Pallavi; Monif, Tausif; Khuroo, Arshad; Kaur, Gurpreet

    2013-05-01

    In this study a rapid, simple and sensitive assay to quantify clozapine in human plasma by using reverse phase high performance liquid chromatographic method has been developed. Clozapine was extracted from human plasma using a mixture of chloroform: n-hexane 50:50 employing liquid-liquid extraction method. The calibration curve was found to be linear in the concentration range of 25-800 ng/ml. The inter day and intra day assay accuracy and precision fulfilled the criteria specified by USFDA, Guidance for industry: bioanalytical method validation. Clozapine was found to be stable in human plasma after 6 h incubation at room temperature, 50 days storage at -27°C and freeze thaw cycles, as well as after reconstitution with mobile phase after 24 h of storage in refrigerator. The validated method offers the advantage of using minimum injection volume (25μl) and plasma sample volume (300μl). The extraction method is simple and single step with no back extraction step, thus, making this method applicable to determination of pharmacokinetic profiles and parameters.

  10. Validity of the BOD POD for assessing body composition in athletic high school boys.

    Science.gov (United States)

    Moon, Jordan R; Tobkin, Sarah E; Costa, Pablo B; Smalls, Marcus; Mieding, William K; O'Kroy, Joseph A; Zoeller, Robert F; Stout, Jeffrey R

    2008-01-01

    The purpose of this study was to validate the percentage of body fat (%BF) values estimated from the BOD POD (BP) with those obtained from hydrostatic weighing (HW) in athletic American high school boys. Additionally, the %BF values measured via near-infrared interactance (NIR), bioelectrical impedance (BIA), and skinfold (SF) were compared to HW to determine the validity of these measures. Thirty white boys (mean age +/- SD = 15.8 +/- 1.0 years) who where currently participating in organized sports volunteered to have their %BF estimated. Measurements were obtained from NIR, BP, BIA, and SF in random order and concluded with HW. The findings from the present study indicated that the NIR and BIA instruments produced significant (P 4.0%BF). The BP produced a significantly (P 0.008) and had the lowest TE values compared to HW. These data suggest that the BP can produce acceptable body fat measures for athletic white boys but is not superior to estimates made by the SF equations used in this study.

  11. Analysis of Experimental Data for High Burnup PWR Spent Fuel Isotopic Validation - Vandellos II Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Ilas, Germina [ORNL; Gauld, Ian C [ORNL

    2011-01-01

    This report is one of the several recent NUREG/CR reports documenting benchmark-quality radiochemical assay data and the use of the data to validate computer code predictions of isotopic composition for spent nuclear fuel, to establish the uncertainty and bias associated with code predictions. The experimental data analyzed in the current report were acquired from a high-burnup fuel program coordinated by Spanish organizations. The measurements included extensive actinide and fission product data of importance to spent fuel safety applications, including burnup credit, decay heat, and radiation source terms. Six unique spent fuel samples from three uranium oxide fuel rods were analyzed. The fuel rods had a 4.5 wt % {sup 235}U initial enrichment and were irradiated in the Vandellos II pressurized water reactor operated in Spain. The burnups of the fuel samples range from 42 to 78 GWd/MTU. The measurements were used to validate the two-dimensional depletion sequence TRITON in the SCALE computer code system.

  12. The Convergence in Spatial Tasks

    Directory of Open Access Journals (Sweden)

    Vladimir P. Kulagin

    2013-01-01

    Full Text Available The article reveals the problem of convergence of direct and inverse problems in Earth Sciences, describes the features and application of these problems, discloses analytical features of direct and inverse problems. The convergence criteria and conditions for convergence were presented. This work is supported by the Grant of the Government of the Russian Federation for support of scientific research, implemented under the supervision of leading scientists in Russian institutions of higher education in the field "Space Research and Technologies" in 2011–2013.

  13. Evidências de validade convergente-discriminante para a avaliação dos tipos profissionais de Holland (ATPH Evidencias de validez convergente-discriminante para la evaluación de los tipos profesionales de Holland (ATPH Convergent-discriminant validity evidences for the avaliation of Holland's professional types (ATPH

    Directory of Open Access Journals (Sweden)

    Ana Paula Porto Noronha

    2013-01-01

    Full Text Available Este estudo teve como objetivo buscar evidências de validade convergente-discriminante para o teste Avaliação dos Tipos Profissionais, de Holland (ATPH, com vistas a verificar as relações com a Escala de Aconselhamento Profissional (EAP. A amostra foi composta por 42 estudantes dos ensinos fundamental e médio de escolas públicas e particulares. A idade variou entre 11 e 26 anos, sendo que participaram 43% de alunos do sexo masculino, 50%, do feminino, e 7% que não informaram o gênero. Os resultados sugeriram correlações significativas entre as dimensões do EAP e as tipologias do ATPH, com magnitudes que variavam de baixas a moderadas. A partir dos dados coletados, concluiu-se que o ATPH pode ajudar na identificação dos interesses de estudantes em processos de orientação profissional e que as evidências de validade foram favoráveis.Este estudio tuvo como objetivo buscar evidencias de validez convergente-discriminante para la prueba Evaluación de los Tipos Profesionales, de Holland (ATPH, con vistas de verificar las relaciones con la Escala de Consejería Profesional (EAP. La muestra estuvo compuesta de 42 estudiantes de los ciclos primario y secundario de escuelas públicas y particulares. La edad varió entre 11 y 26 años, y participaron 43% de alumnos del sexo masculino, 50%, del femenino, y 7% que no informaron el género. Los resultados sugirieron correlaciones significativas entre las dimensiones del EAP y las tipologías del ATPH, con magnitudes que variaban de bajas a moderadas. A partir de los datos recolectados, se concluyó que el ATPH puede ayudar en la identificación de los intereses de estudiantes en procesos de orientación profesional y que las evidencias de validez fueron favorables.The present study aimed to search convergent-discriminant validity evidences for Holland's test Avaliação dos Tipos Profissionais (ATPH by verifying its relations with the Escala de Aconselhamento Profissional (EAP. The sample

  14. Multidimensional Convergence in Future 5G Networks

    Science.gov (United States)

    Ruffini, Marco

    2017-02-01

    Future 5G services are characterised by unprecedented need for high rate, ubiquitous availability, ultra-low latency and high reliability. The fragmented network view that is widespread in current networks will not stand the challenge posed by next generations of users. A new vision is required, and this paper provides an insight on how network convergence and application-centric approaches will play a leading role towards enabling the 5G vision. The paper, after expressing the view on the need for an end-to-end approach to network design, brings the reader into a journey on the expected 5G network requirements and outlines some of the work currently carried out by main standardisation bodies. It then proposes the use of the concept of network convergence for providing the overall architectural framework to bring together all the different technologies within a unifying and coherent network ecosystem. The novel interpretation of multi-dimensional convergence we introduce leads us to the exploration of aspects of node consolidation and converged network architectures, delving into details of optical-wireless integration and future convergence of optical data centre and access-metro networks. We then discuss how ownership models enabling network sharing will be instrumental in realising the 5G vision. The paper concludes with final remarks on the role SDN will play in 5G and on the need for new business models that reflect the application-centric view of the network. Finally, we provide some insight on growing research areas in 5G networking.

  15. High-frequency Heating Behavior of Veneer-based Composites: Modelling and Validation

    Directory of Open Access Journals (Sweden)

    Peixing Wei

    2014-04-01

    Full Text Available A one-dimensional theoretical heat and mass transfer model was developed for high-frequency (HF heating of veneer-based composites, such as laminated veneer lumber (LVL and plywood. This model was based on the basic principles of energy and mass conservation, momentum conservation of gas flow, and gas thermodynamic relations. The response variables, including temperature, gas pressure, and moisture content (MC, were linked to basic material properties, such as veneer density, thermal conductivity, permeability, and dielectric properties. Initial and boundary conditions for solving the governing equations were also considered. The model was further validated by experiments with veneer HF heating and LVL HF heating. The model predictions agreed well with the experimental results. During veneer HF heating, the inner veneer core layers had lower MC than the outer surface layers. Compared to conventional hot platen heating, HF heating was proven to be an efficient and robust method for manufacturing veneer-based composites.

  16. High Level Analysis, Design and Validation of Distributed Mobile Systems with CoreASM

    Science.gov (United States)

    Farahbod, R.; Glässer, U.; Jackson, P. J.; Vajihollahi, M.

    System design is a creative activity calling for abstract models that facilitate reasoning about the key system attributes (desired requirements and resulting properties) so as to ensure these attributes are properly established prior to actually building a system. We explore here the practical side of using the abstract state machine (ASM) formalism in combination with the CoreASM open source tool environment for high-level design and experimental validation of complex distributed systems. Emphasizing the early phases of the design process, a guiding principle is to support freedom of experimentation by minimizing the need for encoding. CoreASM has been developed and tested building on a broad scope of applications, spanning computational criminology, maritime surveillance and situation analysis. We critically reexamine here the CoreASM project in light of three different application scenarios.

  17. Operational characterisation of requirements and early validation environment for high demanding space systems

    Science.gov (United States)

    Barro, E.; Delbufalo, A.; Rossi, F.

    1993-01-01

    The definition of some modern high demanding space systems requires a different approach to system definition and design from that adopted for traditional missions. System functionality is strongly coupled to the operational analysis, aimed at characterizing the dynamic interactions of the flight element with its surrounding environment and its ground control segment. Unambiguous functional, operational and performance requirements are to be defined for the system, thus improving also the successive development stages. This paper proposes a Petri Nets based methodology and two related prototype applications (to ARISTOTELES orbit control and to Hermes telemetry generation) for the operational analysis of space systems through the dynamic modeling of their functions and a related computer aided environment (ISIDE) able to make the dynamic model work, thus enabling an early validation of the system functional representation, and to provide a structured system requirements data base, which is the shared knowledge base interconnecting static and dynamic applications, fully traceable with the models and interfaceable with the external world.

  18. An evidenced-based perspective on the validity of attention-deficit/hyperactivity disorder in the context of high intelligence.

    Science.gov (United States)

    Rommelse, Nanda; van der Kruijs, Marieke; Damhuis, Jochem; Hoek, Ineke; Smeets, Stijn; Antshel, Kevin M; Hoogeveen, Lianne; Faraone, Stephen V

    2016-12-01

    The validity of Attention-Deficit/Hyperactivity Disorder (ADHD) in individuals with high intelligence is disputed, since high intelligence may 'mimic' the symptoms of ADHD in the absence of the specific pathophysiological pathways for ADHD. Conversely, increased risk of a missed ADHD diagnosis may occur due to compensatory strategies in the highly intelligent individual. A systematic literature review was performed including cognitive and behavioral studies, addressing a specific set of criteria for validating ADHD in the context of high intelligence. Albeit limited in number, available results suggest that ADHD is a valid construct in the context of high intelligence, showing characteristic clinical features (except possibly for hyperactivity being a less specific pathology marker), course and outcome and a characteristic response to treatment. Importantly, ADHD and IQ are negatively correlated on nearly all phenotypic and cognitive constructs, underlining the need for taking IQ into account as potential moderator in ADHD studies and more systematically studying ADHD in the high intelligent population.

  19. WEAK CONVERGENCE OF SOME SERIES

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper continues the study of [1] on weak functions.The weak convergence theory is investigated in complex analysis,Fourier transform and Mellin transform.A Mobius inverse formula of weak functions is obtained.

  20. Dynamical Convergence Trajectory in Networks

    Institute of Scientific and Technical Information of China (English)

    TAN Ning; ZHANG Yun-Jun; OUYANG Qi; GENG Zhi

    2005-01-01

    @@ It is well known that topology and dynamics are two major aspects to determine the function of a network. We study one of the dynamic properties of a network: trajectory convergence, i.e. how a system converges to its steady state. Using numerical and analytical methods, we show that in a logical-like dynamical model, the occurrence of convergent trajectory in a network depends mainly on the type of the fixed point and the ratio between activation and inhibition links. We analytically proof that this property is induced by the competition between two types of state transition structures in phase space: tree-like transition structure and star-like transition structure. We show that the biological networks, such as the cell cycle network in budding yeast, prefers the tree-like transition structures and suggest that this type of convergence trajectories may be universal.

  1. Spaces of Ideal Convergent Sequences

    Directory of Open Access Journals (Sweden)

    M. Mursaleen

    2014-01-01

    Full Text Available In the present paper, we introduce some sequence spaces using ideal convergence and Musielak-Orlicz function ℳ=Mk. We also examine some topological properties of the resulting sequence spaces.

  2. Validation of high performance liquid chromatography method for determination of meloxicam loaded PEGylated nanocapsules

    Directory of Open Access Journals (Sweden)

    Francine Rodrigues Ianiski

    2015-12-01

    Full Text Available abstract A method to ensure that an analytical method will produce reliable and interpretable information about the sample must first be validated, making sure that the results can be trusted and traced. In this study, we propose to validate an analytical high performance liquid chromatography (HPLC method for the quantitation of meloxicam loaded PEGylated nanocapsules(M-PEGNC. We performed a validation study, evaluated parameters including specificity, linearity, quantification limit, detection limit, accuracy, precision and robustness. PEGylated nanocapsules were prepared by interfacial deposition of preformed polymer, and the particle size, polydispersity index, zeta potential, pH value and encapsulation efficiency were characterized. The proposed HPLC method provides selective, linear results in the range of 1.0-40.0 μg/mL; quantification and detection limits were 1.78 μg/mL and 0.59 μg/mL, respectively; relative standard deviation for repeatability was 1.35% and intermediate precision was 0.41% and 0.61% for analyst 1 and analyst 2, respectively; accuracy between 99.23 and 101.79%; robustness between 97.13 and 98.45% for the quantification of M-PEGNC. Mean particle diameters were 261 ± 13 nm and 249 ± 20 nm, polydispersity index was 0.15 ± 0.07 and 0.17 ± 0.06, pH values were 5.0 ± 0.2 and 5.2 ± 0.1, and zeta-potential values were -37.9 ± 3.2 mV e -31.8 ± 2.8 mV for M-PEGNC and placebo(B-PEGNC, respectively. In conclusion, the proposed analytical method is suitable for the quality control of M-PEGNC. Moreover, suspensions showed monomodal size distributions and low polydispersity index indicating high homogeneity of formulations with narrow size distributions, and appropriate pH and zeta potential. The extraction process was efficient for release of meloxicam from nanostructured systems.

  3. Weak entropy inequalities and entropic convergence

    Institute of Scientific and Technical Information of China (English)

    GAO FuQing; LI LiNa

    2008-01-01

    A criterion for algebraic convergence of the entropy is presented and an algebraic convergence result for the entropy of an exclusion process is improved.A weak entropy inequality is considered and its relationship to entropic convergence is discussed.

  4. Weak entropy inequalities and entropic convergence

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A criterion for algebraic convergence of the entropy is presented and an algebraic convergence result for the entropy of an exclusion process is improved. A weak entropy inequality is considered and its relationship to entropic convergence is discussed.

  5. Periodic Convergences: Dance and Computers

    OpenAIRE

    deLahunta, Scott

    2002-01-01

    Published in German and English, this chapter is one of deLahunta's major outputs to emerge from a group of related research outputs, concerning "dance and technology". In it he explores the history of the convergence between dance and computers from the 1960s to the 1990s, arguing that this convergence has been periodic, involving particular artists at particular times, rather than producing a genre of work (as others have speculated). As the mainstream of contemporary dance evolved alongsid...

  6. Validation of GEOtop Model for Permafost Research on Steep High-Mountain Bedrock

    Science.gov (United States)

    Pogliotti, P.; Cremonese, E.; Dall'Amico, M.; Gruber, S.; Migliavacca, M.; Morra di Cella, U.

    2009-04-01

    Permafrost distribution in high-mountain environments is influenced in a complex way by topography (micro-climate) and high variability of ground covers conditions (debris, snow, etc.). Also, its direct monitoring is very difficult due to logistical problems like accessibility, costs, weather conditions and reliability of instrumentation. In such conditions physically-based modelling of surface rock/ground temperatures is fundamental for the understanding of mountain permafrost dynamics. With this awareness, a 1D version of GEOtop model has been tested in several high-mountain sites and its accuracy to reproduce near-surface bedrock temperature, solar radiation and snow cover depth, has been evaluated using independent field measurements. GEOtop is a distributed hydrological model with coupled water and energy budgets and is currently under development to suit permafrost research in such complex morphologies. Most of the validation runs have been performed using dataset coming from Corvatsch (3315 m a.s.l., Swiss Alps) since long time-series of meteorological observation are available and many monitoring sites of surface rock temperatures have been equipped during the last years by the University of Zurich. For the validation of modelled snow cover and solar radiation two different dataset coming from Valtournenche (Italian Alps) have been used: Cime Bianche Pass (3100 m a.s.l) and Matterhorn SW ridge (3830 m s.l.m.) equipped by A.R.P.A. Valle d'Aosta. On each site, a 1D GEOtop simulation of temporal duration equal to the full set of meteorological observations (1982-2008) was performed. The first 4 years are used to define the initial conditions by an iterative initialization procedure, in order to obtain an equilibrium between the deep temperature profile and atmospheric conditions. In order to highlight or structural model's deficiencies, ground properties such as albedo, emissivity, thermal conductivity and roughness length are kept fixed over all sites. For

  7. Measure theory of statistical convergence

    Institute of Scientific and Technical Information of China (English)

    CHENG LiXin; LIN GuoChen; LAN YongYi; LIU Hui

    2008-01-01

    The question of establishing measure theory for statistical convergence has been moving closer to center stage, since a kind of reasonable theory is not only fundamental for unifying various kinds of statistical convergence, but also a bridge linking the studies of statistical convergence across measure theory, integration theory, probability and statistics. For this reason, this paper, in terms of subdifferential, first shows a representation theorem for all finitely additive probability measures defined on the σ-algebra of all subsets of N, and proves that every such measure can be uniquely decomposed into a convex combination of a countably additive probability measure and a statistical measure (i.e. a finitely additive probability measure μ with μ(k) = 0 for all singletons {k}). This paper also shows that classical statistical measures have many nice properties, such as: The set of all such measures endowed with the topology of point-wise convergence on forms a compact convex Hausdorff space; every classical statistical measure is of continuity type (hence, atomless), and every specific class of statistical measures fits a complementation minimax rule for every subset in N. Finally, this paper shows that every kind of statistical convergence can be unified in convergence of statistical measures.

  8. Measure theory of statistical convergence

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The question of establishing measure theory for statistical convergence has been moving closer to center stage, since a kind of reasonable theory is not only fundamental for unifying various kinds of statistical convergence, but also a bridge linking the studies of statistical convergence across measure theory, integration theory, probability and statistics. For this reason, this paper, in terms of subdifferential, first shows a representation theorem for all finitely additive probability measures defined on the σ-algebra A of all subsets of N, and proves that every such measure can be uniquely decomposed into a convex combination of a countably additive probability measure and a statistical measure (i.e. a finitely additive probability measure μ with μ(k) = 0 for all singletons {k}). This paper also shows that classical statistical measures have many nice properties, such as: The set S of all such measures endowed with the topology of point-wise convergence on A forms a compact convex Hausdorff space; every classical statistical measure is of continuity type (hence, atomless), and every specific class of statistical measures fits a complementation minimax rule for every subset in N. Finally, this paper shows that every kind of statistical convergence can be unified in convergence of statistical measures.

  9. Validation of a global hydrodynamic flood inundation model against high resolution observation data of urban flooding

    Science.gov (United States)

    Bates, Paul; Sampson, Chris; Smith, Andy; Neal, Jeff

    2015-04-01

    In this work we present further validation results for a hyper-resolution global flood inundation model. We use a true hydrodynamic model that uses highly efficient numerical algorithms (LISFLOOD-FP) to simulate flood inundation at ~1km resolution globally and then use downscaling algorithms to determine flood extent and water depth at 3 seconds of arc spatial resolution (~90m at the equator). The global model has ~150 million cells and requires ~180 hours of CPU time for a 10 year simulation period. Terrain data are taken from a custom version of the SRTM data set that has been processed specifically for hydrodynamic modelling. Return periods of flood flows along the entire global river network are determined using: (1) empirical relationships between catchment characteristics and index flood magnitude in different hydroclimatic zones derived from global runoff data; and (2) an index flood growth curve, also empirically derived. Bankful return period flow is then used to set channel width and depth, and flood defence impacts are modelled using empirical relationships between GDP, urbanization and defence standard of protection. The results of these simulations are global flood hazard maps for a number of different return period events from 1 in 5 to 1 in 1000 years. This method has already been show to compare well to return period flood hazard maps derived from models built with high resolution and accuracy local data (Sampson et al., submitted), yet the output from the global flood model has not yet been compared to real flood observations. Whilst the spatial resolution of the global model is high given the size of the model domain, ~1km resolution is still coarse compared to the models typically used to simulate urban flooding and the data typically used to validate these (~25m or less). Comparison of the global model to real-world observations or urban flooding therefore represents an exceptionally stringent test of model skill. In this paper we therefore

  10. On the Convergence of the Homotopy Analysis Method for Solving Fredholm Integral Equations

    Directory of Open Access Journals (Sweden)

    Behzad GHANBARI

    2013-07-01

    Full Text Available The aim of this paper is to study the convergence of the Homotopy analysis method (HAM for solving Fredholm integral equations. A sufficient condition for convergence of the method is illustrated. The validity of the presented condition for convergence of the HAM is studied for two examples. The comparison of the obtained results by the method with an exact solution shows that the method is reliable and capable of providing analytic treatment for solving such equations.

  11. Validation of the French version of two on high-activity knee questionnaires.

    Science.gov (United States)

    Diesinger, Y; Jenny, J-Y

    2014-09-01

    Self-administered quality-of-life questionnaires are valuable evaluation tools in orthopedic surgery. The conventional questionnaires are limited by a substantial ceiling effect. We wished to validate a French translation of two English questionnaires for high-activity patients: the High-Activity Arthroplasty Score (HAAS) and the Activity Scale for Arthroplasty Patients (ASAP). One hundred patients operated on for knee replacement were selected. The answers to both questionnaires were analyzed and compared to the Oxford Knee Score (OKS) and to the scoring system of the American Knee Society (AKS). There is no correlation between the results of both high-activity questionnaires and of the two conventional scoring systems. All questions were easily understood. The mean scores of the HAAS and ASAP questionnaires were 8.2±3.0 and 30.7±9.6, respectively. The distributions were not considered normal. There was no floor effect, but there was a limited ceiling effect (0% and 14%, respectively). The internal coherence of both questionnaires was satisfactory. There was a significant correlation between the high-activity scores and the conventional scores. Both high-activity questionnaires in our French translation can potentially measure the overall function of a patient after knee replacement as accurately as the index English version. It is self-administered, easy to use, can collect patients' answers by postage mailing, and involves no ceiling effect. All these points should allow its routine use for evaluation after knee replacement. The HAAS evaluation seems to be superior to the ASAP evaluation. Case-control study, level III. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  12. Validation of meter-scale surface faulting offset measurements from high-resolution topographic data

    Science.gov (United States)

    Salisbury, Barrett; Haddad, D.E.; Rockwell, T.K.; Arrowsmith, R.; Madugo, C.; Zielke, O.; Scharer, Katherine M.

    2015-01-01

    Studies of active fault zones have flourished with the availability of high-resolution topographic data, particularly where airborne light detection and ranging (lidar) and structure from motion (SfM) data sets provide a means to remotely analyze submeter-scale fault geomorphology. To determine surface offset at a point along a strike-slip earthquake rupture, geomorphic features (e.g., stream channels) are measured days to centuries after the event. Analysis of these and cumulatively offset features produces offset distributions for successive earthquakes that are used to understand earthquake rupture behavior. As researchers expand studies to more varied terrain types, climates, and vegetation regimes, there is an increasing need to standardize and uniformly validate measurements of tectonically displaced geomorphic features. A recently compiled catalog of nearly 5000 earthquake offsets across a range of measurement and reporting styles provides insight into quality rating and uncertainty trends from which we formulate best-practice and reporting recommendations for remote studies. In addition, a series of public and beginner-level studies validate the remote methodology for a number of tools and emphasize considerations to enhance measurement accuracy and precision for beginners and professionals. Our investigation revealed that (1) standardizing remote measurement methods and reporting quality rating schemes is essential for the utility and repeatability of fault-offset measurements; (2) measurement discrepancies often involve misinterpretation of the offset geomorphic feature and are a function of the investigator’s experience; (3) comparison of measurements made by a single investigator in different climatic regions reveals systematic differences in measurement uncertainties attributable to variation in feature preservation; (4) measuring more components of a displaced geomorphic landform produces more consistently repeatable estimates of offset; and (5

  13. Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas.

    Science.gov (United States)

    Oster, Bodil; Thorsen, Kasper; Lamy, Philippe; Wojdacz, Tomasz K; Hansen, Lise Lotte; Birkenkamp-Demtröder, Karin; Sørensen, Karina D; Laurberg, Søren; Orntoft, Torben F; Andersen, Claus L

    2011-12-15

    In our study, whole-genome methylation arrays were applied to identify novel genes with tumor specific DNA methylation of promoter CpG islands in pre-malignant and malignant colorectal lesions. Using a combination of Illumina HumanMethylation27 beadchips, Methylation-Sensitive High Resolution Melting (MS-HRM) analysis, and Exon arrays (Affymetrix) the DNA methylation pattern of ∼14,000 genes and their transcript levels were investigated in six normal mucosas, six adenomas and 30 MSI and MSS carcinomas. Sixty eight genes with tumor-specific hypermethylation were identified (p mucosas, 12 adenomas, 40 MSS and nine MSI cancer samples. The methylation patterns of 15 selected genes, hypermethylated in adenomas and carcinomas (FLI1, ST6GALNAC5, TWIST1, ADHFE1, JAM2, IRF4, CNRIP1, NRG1 and EYA4), in carcinomas only (ABHD9, AOX1 and RERG), or in MSI but not MSS carcinomas (RAMP2, DSC3 and MLH1) were validated using MS-HRM. Four of these genes (MLH1, AOX1, EYA4 and TWIST1) had previously been reported to be hypermethylated in CRC. Eleven genes, not previously known to be affected by CRC specific hypermethylation, were identified and validated. Inverse correlation to gene expression was observed for six of the 15 genes with Spearman correlation coefficients ranging from -0.39 to -0.60. For six of these genes the altered methylation patterns had a profound transcriptional association, indicating that methylation of these genes may play a direct regulatory role. The hypermethylation changes often occurred already in adenomas, indicating that they may be used as biomarkers for early detection of CRC.

  14. Validation of a high-content screening assay using whole-well imaging of transformed phenotypes.

    Science.gov (United States)

    Ramirez, Christina N; Ozawa, Tatsuya; Takagi, Toshimitsu; Antczak, Christophe; Shum, David; Graves, Robert; Holland, Eric C; Djaballah, Hakim

    2011-06-01

    Automated microscopy was introduced two decades ago and has become an integral part of the discovery process as a high-content screening platform with noticeable challenges in executing cell-based assays. It would be of interest to use it to screen for reversers of a transformed cell phenotype. In this report, we present data obtained from an optimized assay that identifies compounds that reverse a transformed phenotype induced in NIH-3T3 cells by expressing a novel oncogene, KP, resulting from fusion between platelet derived growth factor receptor alpha (PDGFRα) and kinase insert domain receptor (KDR), that was identified in human glioblastoma. Initial image acquisitions using multiple tiles per well were found to be insufficient as to accurately image and quantify the clusters; whole-well imaging, performed on the IN Cell Analyzer 2000, while still two-dimensional imaging, was found to accurately image and quantify clusters, due largely to the inherent variability of their size and well location. The resulting assay exhibited a Z' value of 0.79 and a signal-to-noise ratio of 15, and it was validated against known effectors and shown to identify only PDGFRα inhibitors, and then tested in a pilot screen against a library of 58 known inhibitors identifying mostly PDGFRα inhibitors as reversers of the KP induced transformed phenotype. In conclusion, our optimized and validated assay using whole-well imaging is robust and sensitive in identifying compounds that reverse the transformed phenotype induced by KP with a broader applicability to other cell-based assays that are challenging in HTS against chemical and RNAi libraries.

  15. Validation of meter-scale surface faulting offset measurements from high-resolution topographic data

    KAUST Repository

    Salisbury, J. Barrett

    2015-10-24

    Studies of active fault zones have flourished with the availability of high-resolution topographic data, particularly where airborne light detection and ranging (lidar) and structure from motion (SfM) data sets provide a means to remotely analyze submeter- scale fault geomorphology. To determine surface offset at a point along a strike-slip earthquake rupture, geomorphic features (e.g., stream channels) are measured days to centuries after the event. Analysis of these and cumulatively offset features produces offset distributions for successive earthquakes that are used to understand earthquake rupture behavior. As researchers expand studies to more varied terrain types, climates, and vegetation regimes, there is an increasing need to standardize and uniformly validate measurements of tectonically displaced geomorphic features. A recently compiled catalog of nearly 5000 earthquake offsets across a range of measurement and reporting styles provides insight into quality rating and uncertainty trends from which we formulate best-practice and reporting recommendations for remote studies. In addition, a series of public and beginner-level studies validate the remote methodology for a number of tools and emphasize considerations to enhance measurement accuracy and precision for beginners and professionals. Our investigation revealed that (1) standardizing remote measurement methods and reporting quality rating schemes is essential for the utility and repeatability of fault-offset measurements; (2) measurement discrepancies often involve misinterpretation of the offset geomorphic feature and are a function of the investigator\\'s experience; (3) comparison of measurements made by a single investigator in different climatic regions reveals systematic differences in measurement uncertainties attributable to variation in feature preservation; (4) measuring more components of a displaced geomorphic landform produces more consistently repeatable estimates of offset; and (5

  16. Validation of stability indicating high performance liquid chromatographic method for estimation of Desloratadine in tablet formulation

    Directory of Open Access Journals (Sweden)

    R.B. Patel

    2017-02-01

    Full Text Available A simple, sensitive and specific stability indicating high performance liquid chromatographic (HPLC method for the estimation of Desloratadine was developed and validated. Desloratadine was separated and quantitated on Inertsil ODS-3 V column (250 mm length, 4.6 mm id, 5 μm particle size using a mixture of methanol–phosphate buffer of pH 7.0 (70:30 v/v as a mobile phase and at a flow rate of 1.0 mL/min. Quantification was achieved with an UV detector at 254 nm over the concentration range of 5–75 μg/mL. The applied HPLC method allowed the separation and quantification of Desloratadine with good linearity (r2 = 0.999 in the studied concentration range. Limit of detection and limit of quantification were found to be 1.28 μg/mL and 3.89 μg/mL, respectively. The method was validated as per the International Conference on Harmonization (ICH guidelines. Desloratadine stock solution was subjected to different stress conditions. The degraded product peaks were well resolved from the pure drug peak with significant difference in their retention time values. Stressed samples were assayed using developed HPLC method. Statistical analysis of the data showed that the method is precise, accurate, reproducible, and selective for the analysis of Desloratadine. The method was successfully applied to the estimation of Desloratadine in tablet dosage form.

  17. Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets

    OpenAIRE

    Romero, Diego; Gil, Andrés; Rojas,Jaime

    2009-01-01

    In this paper we present the results obtained during the validation of a UV spectrometric meted for the assay of codeine phosphate in tablets and in uniformity of content test. Also we report the results obtained in the validation of a reverse high performance method developed for the determination of codeine phosphate in the dissolution test and in the quality control with release purpose. As stationary bounded phase we used octadecylsilane and a mobile phase composed of acetonitrile-water-t...

  18. Researching the cognitive validity of GEPT High-Intermediate and Advanced Reading: an eye tracking and stimulated recall study

    OpenAIRE

    2016-01-01

    It is important for any language test to establish its cognitive validity in order to ensure that the test elicits from test takers those cognitive processes which correspond to the processes which they would normally employ in the target real-life context (Weir 2005). This study investigates the cognitive validity of the GEPT Reading Test at two levels. High-intermediate (CEFR B2) and Advanced (CEFR C1), using innovative eye-tracking technology and detailed stimulated recall interviews and s...

  19. Validation of the Social Inclusion Scale with Students

    Directory of Open Access Journals (Sweden)

    Ceri Wilson

    2015-07-01

    Full Text Available Interventions (such as participatory arts projects aimed at increasing social inclusion are increasingly in operation, as social inclusion is proving to play a key role in recovery from mental ill health and the promotion of mental wellbeing. These interventions require evaluation with a systematically developed and validated measure of social inclusion; however, a “gold-standard” measure does not yet exist. The Social Inclusion Scale (SIS has three subscales measuring social isolation, relations and acceptance. This scale has been partially validated with arts and mental health project users, demonstrating good internal consistency. However, test-retest reliability and construct validity require assessment, along with validation in the general population. The present study aimed to validate the SIS in a sample of university students. Test-retest reliability, internal consistency, and convergent validity (one aspect of construct validity were assessed by comparing SIS scores with scores on other measures of social inclusion and related concepts. Participants completed the measures at two time-points seven-to-14 days apart. The SIS demonstrated high internal consistency and test-retest reliability, although convergent validity was less well-established and possible reasons for this are discussed. This systematic validation of the SIS represents a further step towards the establishment of a “gold-standard” measure of social inclusion.

  20. Validation of the Social Inclusion Scale with Students

    Directory of Open Access Journals (Sweden)

    Ceri Wilson

    2015-07-01

    Full Text Available Interventions (such as participatory arts projects aimed at increasing social inclusion are increasingly in operation, as social inclusion is proving to play a key role in recovery from mental ill health and the promotion of mental wellbeing. These interventions require evaluation with a systematically developed and validated measure of social inclusion; however, a “gold-standard” measure does not yet exist. The Social Inclusion Scale (SIS has three subscales measuring social isolation, relations and acceptance. This scale has been partially validated with arts and mental health project users, demonstrating good internal consistency. However, test-retest reliability and construct validity require assessment, along with validation in the general population. The present study aimed to validate the SIS in a sample of university students. Test-retest reliability, internal consistency, and convergent validity (one aspect of construct validity were assessed by comparing SIS scores with scores on other measures of social inclusion and related concepts. Participants completed the measures at two time-points seven-to-14 days apart. The SIS demonstrated high internal consistency and test-retest reliability, although convergent validity was less well-established and possible reasons for this are discussed. This systematic validation of the SIS represents a further step towards the establishment of a “gold-standard” measure of social inclusion.

  1. Validation of GAITRite and PROMIS as high-throughput physical function outcome measures following ACL reconstruction.

    Science.gov (United States)

    Papuga, M Owen; Beck, Christopher A; Kates, Stephen L; Schwarz, Edward M; Maloney, Michael D

    2014-06-01

    New healthcare demands for quality measures of elective procedures, such as anterior cruciate ligament (ACL) reconstructive surgery, warrant the establishment of high throughput outcomes for high volume clinics. To this end, we evaluated the PROMIS and GAITRite as physical function outcome measures to quantify early healing and post-operative complications in 106 patients at pre-operative and 3, 10, 20 and 52 weeks post-ACL reconstruction with bone-tendon-bone autograft, and compared the results to the current IKDC validated outcome measure. The results showed that both PROMIS and GAITRite were significantly quicker to administer versus IKDC (pPROMIS and GAITRite detected a significant decrease in physical function at 3 weeks post-operative, and a significant improvement at 10 weeks post-operative versus pre-operative (pPROMIS and IKDC detected significant improvement out to 52 weeks post-operative (pPROMIS, with a combined correlation value of 0.8954 (pPROMIS is a diagnostic test for poor outcomes.

  2. Numerical Simulation and Validation of a High Head Model Francis Turbine at Part Load Operating Condition

    Science.gov (United States)

    Goyal, Rahul; Trivedi, Chirag; Kumar Gandhi, Bhupendra; Cervantes, Michel J.

    2017-07-01

    Hydraulic turbines are operated over an extended operating range to meet the real time electricity demand. Turbines operated at part load have flow parameters not matching the designed ones. This results in unstable flow conditions in the runner and draft tube developing low frequency and high amplitude pressure pulsations. The unsteady pressure pulsations affect the dynamic stability of the turbine and cause additional fatigue. The work presented in this paper discusses the flow field investigation of a high head model Francis turbine at part load: 50% of the rated load. Numerical simulation of the complete turbine has been performed. Unsteady pressure pulsations in the vaneless space, runner, and draft tube are investigated and validated with available experimental data. Detailed analysis of the rotor stator interaction and draft tube flow field are performed and discussed. The analysis shows the presence of a rotating vortex rope in the draft tube at the frequency of 0.3 times of the runner rotational frequency. The frequency of the vortex rope precession, which causes severe fluctuations and vibrations in the draft tube, is predicted within 3.9% of the experimental measured value. The vortex rope results pressure pulsations propagating in the system whose frequency is also perceive in the runner and upstream the runner.

  3. High-speed AMB machining spindle model updating and model validation

    Science.gov (United States)

    Wroblewski, Adam C.; Sawicki, Jerzy T.; Pesch, Alexander H.

    2011-04-01

    High-Speed Machining (HSM) spindles equipped with Active Magnetic Bearings (AMBs) have been envisioned to be capable of automated self-identification and self-optimization in efforts to accurately calculate parameters for stable high-speed machining operation. With this in mind, this work presents rotor model development accompanied by automated model-updating methodology followed by updated model validation. The model updating methodology is developed to address the dynamic inaccuracies of the nominal open-loop plant model when compared with experimental open-loop transfer function data obtained by the built in AMB sensors. The nominal open-loop model is altered by utilizing an unconstrained optimization algorithm to adjust only parameters that are a result of engineering assumptions and simplifications, in this case Young's modulus of selected finite elements. Minimizing the error of both resonance and anti-resonance frequencies simultaneously (between model and experimental data) takes into account rotor natural frequencies and mode shape information. To verify the predictive ability of the updated rotor model, its performance is assessed at the tool location which is independent of the experimental transfer function data used in model updating procedures. Verification of the updated model is carried out with complementary temporal and spatial response comparisons substantiating that the updating methodology is effective for derivation of open-loop models for predictive use.

  4. Validation of a highly integrated SiPM readout system with a TOF-PET demonstrator

    Science.gov (United States)

    Niknejad, T.; Setayeshi, S.; Tavernier, S.; Bugalho, R.; Ferramacho, L.; Di Francesco, A.; Leong, C.; Rolo, M. D.; Shamshirsaz, M.; Silva, J. C.; Silva, R.; Silveira, M.; Zorraquino, C.; Varela, J.

    2016-12-01

    We have developed a highly integrated, fast and compact readout electronics for Silicon Photomultiplier (SiPM) based Time of Flight Positron Emission Tomography (TOF-PET) scanners. The readout is based on the use of TOP-PET Application Specific Integrated Circuit (PETsys TOFPET1 ASIC) with 64 channels, each with its amplifier, discriminator, Time to Digital Converter (TDC) and amplitude determination using Time Over Threshold (TOT). The ASIC has 25 ps r.m.s. intrinsic time resolution and fully digital output. The system is optimised for high rates, good timing, low power consumption and low cost. For validating the readout electronics, we have built a technical PET scanner, hereafter called ``demonstrator'', with 2'048 SiPM channels. The PET demonstrator has 16 compact Detector Modules (DM). Each DM has two ASICs reading 128 SiPM pixels in one-to-one coupling to 128 Lutetium Yttrium Orthosilicate (LYSO) crystals measuring 3.1 × 3.1 × 15 mm3 each. The data acquisition system for the demonstrator has two Front End Boards type D (FEB/D), each collecting the data of 1'024 channels (8 DMs), and transmitting assembled data frames through a serial link (4.8 Gbps), to a single Data Acquisition (DAQ) board plugged into the Peripheral Component Interconnect Express (PCIe) bus of the data acquisition PC. Results obtained with this PET demonstrator are presented.

  5. The cross-validated AUC for MCP-logistic regression with high-dimensional data.

    Science.gov (United States)

    Jiang, Dingfeng; Huang, Jian; Zhang, Ying

    2013-10-01

    We propose a cross-validated area under the receiving operator characteristic (ROC) curve (CV-AUC) criterion for tuning parameter selection for penalized methods in sparse, high-dimensional logistic regression models. We use this criterion in combination with the minimax concave penalty (MCP) method for variable selection. The CV-AUC criterion is specifically designed for optimizing the classification performance for binary outcome data. To implement the proposed approach, we derive an efficient coordinate descent algorithm to compute the MCP-logistic regression solution surface. Simulation studies are conducted to evaluate the finite sample performance of the proposed method and its comparison with the existing methods including the Akaike information criterion (AIC), Bayesian information criterion (BIC) or Extended BIC (EBIC). The model selected based on the CV-AUC criterion tends to have a larger predictive AUC and smaller classification error than those with tuning parameters selected using the AIC, BIC or EBIC. We illustrate the application of the MCP-logistic regression with the CV-AUC criterion on three microarray datasets from the studies that attempt to identify genes related to cancers. Our simulation studies and data examples demonstrate that the CV-AUC is an attractive method for tuning parameter selection for penalized methods in high-dimensional logistic regression models.

  6. Reproducibility and validity of electric source localisation with high-resolution electroencephalography.

    Science.gov (United States)

    Kristeva-Feige, R; Grimm, C; Huppertz, H J; Otte, M; Schreiber, A; Jäger, D; Feige, B; Büchert, M; Hennig, J; Mergner, T; Lücking, C H

    1997-12-01

    The present study investigates the reproducibility and validity of the EEG source localisation of somatosensory evoked potentials (SEPs) using high-resolution EEG (61 scalp electrodes) and a source reconstruction on the basis of the individual brain morphology as obtained from magnetic resonance images (MRIs). The somatosensory evoked potentials (SEPs) to electrical stimulation of the right median nerve were repeatedly collected from the scalp of one healthy subject in 9 replications run on 9 different days. The source reconstruction for the 19 ms SEP component was performed by using a single moving dipole model as a source model. Two different head models were used: a spherical 3 shell model and a more realistically shaped 3 compartment model computed using the boundary element method (BEM). The source locations of the 19 ms SEP component were found to be highly reproducible using both head models: the mean standard deviation of the dipole locations was found to be 2.6 mm for the 3 shell model and 4 mm for the more realistically shaped head model. By projection into the individual MRI, the dipoles resulting from either head models were found to be located within the postcentral gyrus. The electric source locations were consistent with the maximum of the task-specific changes seen in a functional magnetic resonance imaging (fMRI) experiment when using the same somatosensory stimulation protocol.

  7. Trophic convergence drives morphological convergence in marine tetrapods.

    Science.gov (United States)

    Kelley, Neil P; Motani, Ryosuke

    2015-01-01

    Marine tetrapod clades (e.g. seals, whales) independently adapted to marine life through the Mesozoic and Caenozoic, and provide iconic examples of convergent evolution. Apparent morphological convergence is often explained as the result of adaptation to similar ecological niches. However, quantitative tests of this hypothesis are uncommon. We use dietary data to classify the feeding ecology of extant marine tetrapods and identify patterns in skull and tooth morphology that discriminate trophic groups across clades. Mapping these patterns onto phylogeny reveals coordinated evolutionary shifts in diet and morphology in different marine tetrapod lineages. Similarities in morphology between species with similar diets-even across large phylogenetic distances-are consistent with previous hypotheses that shared functional constraints drive convergent evolution in marine tetrapods.

  8. Validation of HFCS-I on Calculation of High-Frequency Parameters of Helical Slow-Wave Structures

    Science.gov (United States)

    Zhu, Xiaofang; Yang, Zhonghai; Li, Bin; Li, Jianqing; Xu, Li

    2010-02-01

    To validate HFCS-I, a newly developed design tool for high frequency circuits of microwave tubes, the high-frequency parameters (including dispersion, interaction impedance and attenuation constant) of a typical helical slow-wave structure (SWS) for millimetre wave travelling-wave tube are calculated by HFCS-I and MAFIA. Both the direct calculation method and the Non-Resonant Perturbation (NRP) technique are adopted to get the interaction impedance. The obtained high-frequency parameters from HFCS-I and MAFIA are compared in detail and the consistency has proved the reliability and validity of HFCS-I.

  9. Error attribution and validation of SMOS high-level salinity products with Argo data

    Science.gov (United States)

    Ballabrera, Joaquim

    2015-04-01

    available for December 2013. Valid observations in the top five meters have been 2600 and 235, respectively. Comparison between Argo data and SMOS illustrates some of the systematic deficiencies of the salinity retrieval approach. Among them, land-sea contamination and model deficiencies at low and high temperatures. Moreover, Argo data may illustrate some deficiencies one of the auxiliary fields, namely the Sea Surface Temperature, used in the retrieval approach. When the Argo and SMOS match-up pairs data are properly filtered, the mean and standard deviation of the differences in the latitudinal band of 60S-60N are (L3/OI/L4): -0.00/-0.01/-0.06 and 0.49/0.29/0.28. When match-up pairs are limited to the 30S-30N band the mean and standard deviation are -0.02/-0.03/-0.12 and 0.37/0.23/0.23. While these figures have been found to be robust when Argo observations are taken deeper than five meters, their differ when Argo data is restricted to the first four meters of the ocean. However, more upper-surface measurements are required to elucidate the robustness of these changes.

  10. Short- and Long-Term Validity of High School GPA for Admission to Colleges outside the United States

    Science.gov (United States)

    Al-Hattami, Abdulghani

    2014-01-01

    High school GPA is the only admission criterion that is currently used by many colleges in Yemen to select their potential students. Its predictive validity was investigated to ensure the accuracy of the admission decisions in these colleges. The relationship between students' persistence in the 4 years of college and high school GPA was studied…

  11. Predicting high-cost pediatric patients: derivation and validation of a population-based model.

    Science.gov (United States)

    Leininger, Lindsey J; Saloner, Brendan; Wherry, Laura R

    2015-08-01

    Health care administrators often lack feasible methods to prospectively identify new pediatric patients with high health care needs, precluding the ability to proactively target appropriate population health management programs to these children. To develop and validate a predictive model identifying high-cost pediatric patients using parent-reported health (PRH) measures that can be easily collected in clinical and administrative settings. Retrospective cohort study using 2-year panel data from the 2001 to 2011 rounds of the Medical Expenditure Panel Survey. A total of 24,163 children aged 5-17 with family incomes below 400% of the federal poverty line were included in this study. Predictive performance, including the c-statistic, sensitivity, specificity, and predictive values, of multivariate logistic regression models predicting top-decile health care expenditures over a 1-year period. Seven independent domains of PRH measures were tested for predictive capacity relative to basic sociodemographic information: the Children with Special Health Care Needs (CSHCN) Screener; subjectively rated health status; prior year health care utilization; behavioral problems; asthma diagnosis; access to health care; and parental health status and access to care. The CSHCN screener and prior year utilization domains exhibited the highest incremental predictive gains over the baseline model. A model including sociodemographic characteristics, the CSHCN screener, and prior year utilization had a c-statistic of 0.73 (95% confidence interval, 0.70-0.74), surpassing the commonly used threshold to establish sufficient predictive capacity (c-statistic>0.70). The proposed prediction tool, comprising a simple series of PRH measures, accurately stratifies pediatric populations by their risk of incurring high health care costs.

  12. Developing and validating a chemical bonding instrument for Korean high school students

    Science.gov (United States)

    Jang, Nak Han

    The major purpose of this study was to develop a reliable and valid instrument designed to collect and investigate on Korean high school students' understanding about concepts regarding chemical bonding. The Chemical Bonding Diagnostic Test (CBDT) was developed by the procedure by previously relevant researches (Treagust, 1985; Peterson, 1986; Tan, 1994). The final instrument consisted of 15 two-tier items. The reliability coefficient (Cronbach alpha) for the whole test was 0.74. Also, the range of values for the discrimination index was from 0.38 to 0.90 and the overall average difficulty index was 0.38. The test was administered to 716 science declared students in Korean high school. The 37 common misconceptions on chemical bonding were identified through analysis of the items from the CBDT. The grade 11 students had slightly more misconceptions than the grade 12 students for ionic bonding, covalent bonding, and hydrogen bonding while the grade 12 students had more misconceptions about octet rule and hydrogen bonding than the grade 11 students. From the analysis of ANCOVA, there was no significant difference in grades, and between grade levels and gender on the mean score of CBDT. However, there was a significant difference in gender and a significant interaction between grade levels and chemistry preference. In conclusion, Korean high school students had the most common misconception about the electron configuration on ionic bonding and the water density on hydrogen bonding. Korean students' understanding about the chemical bonding was dependent on the interaction between grade levels and the chemistry preference. Consequently, grade 12 chemistry-preferred students had the highest mean scores among student groups concerned by this study.

  13. VISAR Validation Test Series at the Light Initiated High Explosive (LIHE) facility.

    Energy Technology Data Exchange (ETDEWEB)

    Covert, Timothy Todd

    2007-02-01

    A velocity interferometer system for any reflector (VISAR) was recently deployed at the light initiated high explosive facility (LIHE) to measure the velocity of an explosively accelerated flyer plate. The velocity data from the flyer plate experiments, using the vendor's fringe constant of 100m/s/fringe, were consistently lower than model predictions. The goal of the VISAR validation test series was to confirm the VISAR system fringe constant. A low velocity gas gun was utilized to impact and accelerate a target at the LIHE facility. VISAR velocity data from the accelerated target was compared against an independent velocity measurement. The data from this test series did in fact reveal the fringe constant was significantly higher than the vendor's specification. The correct fringe constant for the LIHE VISAR system has been determined to be 123 m/s/fringe. The Light Initiated High Explosive (LIHE) facility recently completed a Phase I test series to develop an explosively accelerated flyer plate (X-Flyer). The X-Flyer impulse technique consists of first spraying a thin layer of silver acetylide silver nitrate explosive onto a thin flyer plate. The explosive is then initiated using an intense flash of light. The explosive detonation accelerates the flyer across a small air gap towards the test item. The impact of the flyer with the test item creates a shock pulse and an impulsive load in the test unit. The goal of Phase I of the X-Flyer development series was to validate the technique theory and design process. One of the key parameters that control the shock pulse and impulsive load is the velocity of the flyer at impact. To measure this key parameter, a velocity interferometer system for any reflector (VISAR) was deployed at the LIHE facility. The VISAR system was assembled by Sandia personnel from the Explosive Projects and Diagnostics department. The VISAR was a three leg, push-pull system using a fixed delay cavity. The primary optical components

  14. Convergence of obesity and high glycemic diet on compounding diabetes and cardiovascular risks in modernizing China: An emerging public health dilemma

    OpenAIRE

    2008-01-01

    Abstract As China is undergoing dramatic development, it is also experiencing major societal changes, including an emerging obesity epidemic, with the prevalence of overweight and obesity doubling in the past decade. However, the implications of a high glycemic index (GI) and glycemic load (GL) traditional Chinese diet are adversely changing in modern times, as a high-glycemic diet is becoming a greater contributor to diabetes and cardiovascular risks in a population with rising obesity and d...

  15. High Thermoelectric Performance by Convergence of Bands in IV-VI Semiconductors, Heavily Doped PbTe, and Alloys/Nanocomposites

    Science.gov (United States)

    Snyder, G. Jeffrey (Inventor); Pei, Yanzhong (Inventor)

    2015-01-01

    The present invention teaches an effective mechanism for enhancing thermoelectric performance through additional conductive bands. Using heavily doped p-PbTe materials as an example, a quantitative explanation is disclosed, as to why and how these additional bands affect the figure of merit. A high zT of approaching 2 at high temperatures makes these simple, likely more stable (than nanostructured materials) and Tl-free materials excellent for thermoelectric applications.

  16. Digital Convergence and Content Regulation

    Directory of Open Access Journals (Sweden)

    Michael John Starks

    2014-12-01

    Full Text Available Broadcasting, Press and Internet journalism systems of distribution are converging: the same infrastructure can deliver all three historically separate services. Reception devices mirror this: the Connected TV, the tablet and the smart phone overlap in their functionality. Service overlaps are evident too, with broadcasters providing online and on-demand services and newspapers developing electronic versions. Does this mean that media regulation policies must converge too?My argument is that they should, though only where historically different communications are now fulfilling a similar function, e.g. broadcaster online services and electronic versions of newspapers. Convergence requires a degree of harmonisation and, to this end, I advocate a review of UK broadcasting's 'due impartiality' requirement and of the UK's application of the public service concept. I also argue for independent self-regulation (rather than state-based regulation of non-public-service broadcasting journalism.

  17. Are China and Europe converging?

    Institute of Scientific and Technical Information of China (English)

    Bastianin; Andrea; Cattanceo; Cristina; Markandya; Anil

    2009-01-01

    This analysis aims at giving a flavour of what is happening between the European and Chinese markets with reference to selected energy indicators and economic variables. More precisely the analysis is concerned with the convergence between European countries (EU15 + Norway) and China in terms of both per capita GDP and "sustainability indicators". The variables we refer to as "sustainability indicators" are two: energy intensity (EI) and carbon intensity (CI). The paths of such variables will be investigated both looking at the economy as a whole and by analysing what is happening in three sectors of economic activity, namely industry, agriculture and services. It finds strong evidence of convergence in energy intensity and carbon intensity between the EU and China, with rates fast enough to achieve 90% convergence in a matter of two decades.

  18. Description and validation of coupling high performance liquid chromatography with resonance Rayleigh scattering in aminoglycosides determination

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Lei [Chemistry and Chemical Engineering, Southwest University, 400715 Chongqing (China); Peng Jingdong, E-mail: hxpengjd@swu.edu.cn [Chemistry and Chemical Engineering, Southwest University, 400715 Chongqing (China); Tang Jinxia; Yuan Binfang; He Rongxing; Xiao Ying [Chemistry and Chemical Engineering, Southwest University, 400715 Chongqing (China)

    2011-11-14

    Graphical abstract: Theoretical and experimental analysis had proved that aminoglycosides reacted with Congo red to form binary compounds simultaneously, which led to a novel HPLC-RRS strategy being applied in substances which are not fluorescing and not UV absorbed. Highlights: {yields} A novel HPLC-RRS strategy was shown in this study. {yields} Theoretical and experimental analysis had proved the feasibility of this method. {yields} Because of its specificity, no interference from the matrix was observed. {yields} The analytes in biological matrix were all well resolved without any interference. {yields} It provided new insights for analytes lack of useful spectroscopic and electrochemical properties. - Abstract: In view of the fact that many substances generally exhibit very little ultraviolet absorbance and the absence of native fluorescence, a new strategy with simple instrumentation and excellent analytical performance combining high performance liquid chromatography (HPLC) with resonance Rayleigh scattering (RRS) was developed. It was validated for the quantification of aminoglycosides (AGs). This fact was also carefully calculated by quantum chemistry. However, the sensitivity was probably limited by the volume of flow-through cell. Therefore, the result calls for a suitable one to ensure optimal RRS signal. Interestingly, when serum or urine samples of analytes were analyzed by this method, they were all well resolved without any interference, which would hold a new perspective to be applied in the determination of substances in biological matrix.

  19. Models of TCP in high-BDP environments and their experimental validation

    Energy Technology Data Exchange (ETDEWEB)

    Vardoyan, G. [University of Massachusetts; Rao, Nageswara S [ORNL; Towlsey, D. [University of Massachusetts

    2016-01-01

    In recent years, the computer networking community has seen a steady growth in bandwidth-delay products (BDPs). Several TCP variants were created to combat the shortcomings of legacy TCP when it comes to operation in high-BDP environments. These variants, among which are CUBIC, STCP, and H-TCP, have been extensively studied in some empirical contexts, and some analytical models exist for CUBIC and STCP. However, since these studies have been conducted, BDPs have risen even more, and new bulk data transfer tools have emerged that utilize multiple parallel TCP streams. In view of these new developments, it is imperative to revisit the question: Which congestion control algorithms are best adapted to current networking environments? In order to help resolve this question, we contribute the following: (i) using first principles, we develop a general throughput-prediction framework that takes into account buffer sizes and maximum window constraints; (ii) we validate the models using measurements and achieve low prediction errors; (iii) we note differences in TCP dynamics between two experimental configurations and find one of them to be significantly more deterministic than the other; we also find that CUBIC and H-TCP outperform STCP, especially when multiple streams are used; and (iv) we present preliminary results for modelling multiple TCP streams for CUBIC and STCP.

  20. Development and validation of a high-performance liquid chromatographic method for bioanalytical application with rimonabant.

    Science.gov (United States)

    Bhaumik, Uttam; Ghosh, Animesh; Chatterjee, Bappaditya; Sengupta, Pinaki; Darbar, Soumendra; Roy, Bikash; Nandi, Utpal; Pal, Tapan K

    2009-05-01

    A simple and feasible high-performance liquid chromatographic method with UV detection was developed and validated for the quantification of rimonabant in human plasma. The chromatographic separation was carried out in a Hypersil BDS, C(18) column (250 mm x 4.6mm; 5 microm). The mobile phase was a mixture of 10 mM phosphate buffer and acetonitrile (30:70, v/v) at a flow rate of 1.0 ml/min. The UV detection was set at 220 nm. The extraction recovery of rimonabant in plasma at three quality control (QC) samples was ranged from 84.17% to 92.64%. The calibration curve was linear for the concentration range of 20-400 ng/ml with the correlation coefficient (r(2)) above 0.9921. The method was specific and sensitive with the limit of quantification of 20 ng/ml. The accuracy and precision values obtained from six different sets of QC samples analyzed in separate occasions ranged from 88.13% to 106.48% and 0.13% to 3.61%, respectively. In stability tests, rimonabant in human plasma was stable during storage and assay procedure. The method is very simple, sensitive and economical and the assay was applied to human plasma samples in a clinical (pharmacokinetic) study of rimonabant.

  1. Validation of a Predictive Model to Identify Patients at High Risk for Hospital Readmission.

    Science.gov (United States)

    Spiva, LeeAnna; Hand, Marti; VanBrackle, Lewis; McVay, Frank

    2016-01-01

    Hospital readmission is an adverse patient outcome that is serious, common, and costly. For hospitals, identifying patients at risk for hospital readmission is a priority to reduce costs and improve care. The purposes were to validate a predictive algorithm to identify patients at a high risk for preventable hospital readmission within 30 days after discharge and determine if additional risk factors enhance readmission predictability. A retrospective study was conducted on a randomized sample of 598 patients discharged from a Southeast community hospital. Data were collected from the organization's database and manually abstracted from the electronic medical record using a structured tool. Two separate logistic regression models were fit for the probability of readmission within 30 days after discharge. The first model used the LACE index as the predictor variable, and the second model used the LACE index with additional risk factors. The two models were compared to determine if additional risk factors increased the model's predictive ability. The results indicate both models have reasonable prognostic capability. The LACE index with additional risk factors did little to improve prognostication, while adding to the model's complexity. Findings support the use of the LACE index as a practical tool to identify patients at risk for readmission.

  2. Validated high-performance thin-layer chromatography method for steviol glycosides in Stevia rebaudiana.

    Science.gov (United States)

    Jaitak, Vikas; Gupta, A P; Kaul, V K; Ahuja, P S

    2008-08-05

    A high-performance thin-layer chromatographic (HPTLC) method was developed and validated as per ICH (International Conferences on Harmonization) guidelines for simultaneous quantification of three steviol glycosides, i.e. steviolbioside, stevioside and rebaudioside-A in Stevia rebaudiana leaves. For achieving good separation, mobile phase of ethyl acetate-ethanol-water (80:20:12, v/v/v) on pre-coated silica gel 60 F254 HPTLC plates were used. The densitometric quantification of steviol glycosides was carried out at lambda=510 nm in reflection-absorption mode after spraying with acetic anhydride:sulphuric acid:ethanol reagent. The calibration curves were linear in the range of 160-960 ng/spot for steviolbioside, 1-6 microg/spot for stevioside and 0.5-3 microg/spot for rebaudioside-A with good correlation coefficients (0.998-0.999). The method was found to be reproducible for quantitative analysis of steviol glycosides in S. rebaudiana leaves collected from ten different locations and will serve as a quality control indicator to monitor the commercial production of stevioside and its allied molecules during different stages of its processing.

  3. Escala Baptista de Depressão (Versão Adulto - EBADEP-A: validade convergente e estabilidade temporal Escala Baptista de Depresión (Versión Adulto - EBADEP-A: validez convergente y estabilidad temporal Escala Baptista de Depressão (Versão Adulto - EBADEP-A: convergent validity and temporal stability

    Directory of Open Access Journals (Sweden)

    Makilim Nunes Baptista

    2012-12-01

    convergent validity between the Escala Baptista de Depressão (Versão Adulto - EBADEP-A and the Beck Depression Inventory II - BDI-II, and to assess the temporal stability of EBADEP-A through the test and re-test method in a one-month period. The present study included 173 college students with an average of 24.45 years of age (SD=8.45, mostly women. After a one month period, 65 participants, mostly women (90.8%, with an average of 21 years of age (SD=5.48 answered the instrument a second time. The results showed, according to international standards, high correlation indices between scales, and the test-retest as well, demonstrating adequate psychometric qualities of EBADEP-A also in these questions, confirming other previous studies. These results and the limitations of the study are also discussed.

  4. Convergence of obesity and high glycemic diet on compounding diabetes and cardiovascular risks in modernizing China: An emerging public health dilemma

    Directory of Open Access Journals (Sweden)

    Malik Vasanti S

    2008-02-01

    Full Text Available Abstract As China is undergoing dramatic development, it is also experiencing major societal changes, including an emerging obesity epidemic, with the prevalence of overweight and obesity doubling in the past decade. However, the implications of a high glycemic index (GI and glycemic load (GL traditional Chinese diet are adversely changing in modern times, as a high-glycemic diet is becoming a greater contributor to diabetes and cardiovascular risks in a population with rising obesity and decreasing physical activity. Specifically, a high GI diet adversely impacts metabolism and appetite control regulation, and notably confers substantially greater risk of weight gain, type 2 diabetes, cardiovascular disease, and certain cancers among overweight and obese individuals (P

  5. DOES THE MAASTRICHT CONVERGENCE CRITERIA WORK?

    Directory of Open Access Journals (Sweden)

    Karsai Zoltán-Krisztián

    2012-12-01

    seven countries analyzed. France and Germany, characterized by healthy fiscal and economic policies is also exposed to risks stemming from the evolution of the private debt. In case of Greece, Ireland and Spain the high current account deficit represented a significant explanatory variable, while the outstanding loans to the private sector proved to be significant in the case of Ireland, Italy and Portugal. The significance of real labour productivity for Greece and Italy proves that real convergence should also be obtained beside nominal convergence by economies in the currency block. All significant variables had explanatory power through their lagged value, hence counterbalancing policies can be elaborated in a timely manner in order to stabilize the economy if signs indicate a potentially unsustainable economic path.

  6. Converging Information and Communication Systems

    DEFF Research Database (Denmark)

    Øst, Alexander

    2003-01-01

    This Ph.D.-project investigates the process of convergence between television and computers. Identifying three “promises of convergence”: interoperability, quality and interactivity, the project examines the key properties of the computer and television sectors, which have had - or are expected...... in the future to have - significant importance to the process and consequences of the convergence. The project focuses on the appliances, i.e. the TV sets, the computers and their peripheral equipment. It also takes into account the infrastructure and signals, which contain and deliver the information...... and communication, as well as the nature of the content and the usage scenarios of consumers....

  7. The benefits of convergence.

    Science.gov (United States)

    Chang, Gee-Kung; Cheng, Lin

    2016-03-06

    A multi-tier radio access network (RAN) combining the strength of fibre-optic and radio access technologies employing adaptive microwave photonics interfaces and radio-over-fibre (RoF) techniques is envisioned for future heterogeneous wireless communications. All-band radio spectrum from 0.1 to 100 GHz will be used to deliver wireless services with high capacity, high link speed and low latency. The multi-tier RAN will improve the cell-edge performance in an integrated heterogeneous environment enabled by fibre-wireless integration and networking for mobile fronthaul/backhaul, resource sharing and all-layer centralization of multiple standards with different frequency bands and modulation formats. In essence, this is a 'no-more-cells' architecture in which carrier aggregation among multiple frequency bands can be easily achieved with seamless handover between cells. In this way, current and future mobile network standards such as 4G and 5G can coexist with optimized and continuous cell coverage using multi-tier RoF regardless of the underlying network topology or protocol. In terms of users' experience, the future-proof approach achieves the goals of system capacity, link speed, latency and continuous heterogeneous cell coverage while overcoming the bandwidth crunch in next-generation communication networks. © 2016 The Author(s).

  8. A self-learning camera for the validation of highly variable and pseudorandom patterns

    Science.gov (United States)

    Kelley, Michael

    2004-05-01

    Reliable and productive manufacturing operations have depended on people to quickly detect and solve problems whenever they appear. Over the last 20 years, more and more manufacturing operations have embraced machine vision systems to increase productivity, reliability and cost-effectiveness, including reducing the number of human operators required. Although machine vision technology has long been capable of solving simple problems, it has still not been broadly implemented. The reason is that until now, no machine vision system has been designed to meet the unique demands of complicated pattern recognition. The ZiCAM family was specifically developed to be the first practical hardware to meet these needs. To be able to address non-traditional applications, the machine vision industry must include smart camera technology that meets its users" demands for lower costs, better performance and the ability to address applications of irregular lighting, patterns and color. The next-generation smart cameras will need to evolve as a fundamentally different kind of sensor, with new technology that behaves like a human but performs like a computer. Neural network based systems, coupled with self-taught, n-space, non-linear modeling, promises to be the enabler of the next generation of machine vision equipment. Image processing technology is now available that enables a system to match an operator"s subjectivity. A Zero-Instruction-Set-Computer (ZISC) powered smart camera allows high-speed fuzzy-logic processing, without the need for computer programming. This can address applications of validating highly variable and pseudo-random patterns. A hardware-based implementation of a neural network, Zero-Instruction-Set-Computer, enables a vision system to "think" and "inspect" like a human, with the speed and reliability of a machine.

  9. The validation and clinical implementation of BRCAplus: a comprehensive high-risk breast cancer diagnostic assay.

    Directory of Open Access Journals (Sweden)

    Hansook Kim Chong

    Full Text Available Breast cancer is the most commonly diagnosed cancer in women, with 10% of disease attributed to hereditary factors. Although BRCA1 and BRCA2 account for a high percentage of hereditary cases, there are more than 25 susceptibility genes that differentially impact the risk for breast cancer. Traditionally, germline testing for breast cancer was performed by Sanger dideoxy terminator sequencing in a reflexive manner, beginning with BRCA1 and BRCA2. The introduction of next-generation sequencing (NGS has enabled the simultaneous testing of all genes implicated in breast cancer resulting in diagnostic labs offering large, comprehensive gene panels. However, some physicians prefer to only test for those genes in which established surveillance and treatment protocol exists. The NGS based BRCAplus test utilizes a custom tiled PCR based target enrichment design and bioinformatics pipeline coupled with array comparative genomic hybridization (aCGH to identify mutations in the six high-risk genes: BRCA1, BRCA2, PTEN, TP53, CDH1, and STK11. Validation of the assay with 250 previously characterized samples resulted in 100% detection of 3,025 known variants and analytical specificity of 99.99%. Analysis of the clinical performance of the first 3,000 BRCAplus samples referred for testing revealed an average coverage greater than 9,000X per target base pair resulting in excellent specificity and the sensitivity to detect low level mosaicism and allele-drop out. The unique design of the assay enabled the detection of pathogenic mutations missed by previous testing. With the abundance of NGS diagnostic tests being released, it is essential that clinicians understand the advantages and limitations of different test designs.

  10. Validation of DEMs Derived from High Resolution SAR Data: a Case Study on Barcelona

    Science.gov (United States)

    Sefercik, U. G.; Schunert, A.; Soergel, U.; Watanabe, K.

    2012-07-01

    In recent years, Synthetic Aperture Radar (SAR) data have been widely used for scientific applications and several SAR missions were realized. The active sensor principle and the signal wavelength in the order of centimeters provide all-day and all-weather capabilities, respectively. The modern German TerraSAR-X (TSX) satellite provides high spatial resolution down to one meter. Based on such data SAR Interferometry may yield high quality digital surface models (DSMs), which includes points located on 3d objects such as vegetation, forest, and elevated man-made structures. By removing these points, digital elevation model (DEM) representing the bare ground of Earth is obtained. The primary objective of this paper is the validation of DEMs obtained from TSX SAR data covering Barcelona area, Spain, in the framework of a scientific project conducted by ISPRS Working Group VII/2 "SAR Interferometry" that aims the evaluation of DEM derived from data of modern SAR satellite sensors. Towards this purpose, a DSM was generated with 10 m grid spacing using TSX StripMap mode SAR data and converted to a DEM by filtering. The accuracy results have been presented referring the comparison with a more accurate (10 cm-1 m) digital terrain model (DTM) derived from large scale photogrammetry. The results showed that the TSX DEM is quite coherent with the topography and the accuracy is in between ±8-10 m. As another application, the persistent scatterer interferometry (PSI) was conducted using TSX data and the outcomes were compared with a 3d city model available in Google Earth, which is known to be very precise because it is based on LIDAR data. The results showed that PSI outcomes are quite coherent with reference data and the RMSZ of differences is around 2.5 m.

  11. Rapidly converging multigrid reconstruction of cone-beam tomographic data

    Science.gov (United States)

    Myers, Glenn R.; Kingston, Andrew M.; Latham, Shane J.; Recur, Benoit; Li, Thomas; Turner, Michael L.; Beeching, Levi; Sheppard, Adrian P.

    2016-10-01

    In the context of large-angle cone-beam tomography (CBCT), we present a practical iterative reconstruction (IR) scheme designed for rapid convergence as required for large datasets. The robustness of the reconstruction is provided by the "space-filling" source trajectory along which the experimental data is collected. The speed of convergence is achieved by leveraging the highly isotropic nature of this trajectory to design an approximate deconvolution filter that serves as a pre-conditioner in a multi-grid scheme. We demonstrate this IR scheme for CBCT and compare convergence to that of more traditional techniques.

  12. Towards a Convergent Account of Pragmatic Language Deficits in Children with High-Functioning Autism: Depicting the Phenotype Using the Pragmatic Rating Scale

    Science.gov (United States)

    Lam, Yan Grace; Yeung, Siu Sze Susanna

    2012-01-01

    Despite its prominence, pragmatic characteristic associated with autism is under-explored and thus was not well defined. The present study attempted to depict a relatively comprehensive profile of language pragmatics in children with high-functioning autism (HFA) using the Pragmatic Rating Scale (PRS). Pragmatic behaviors of 26 HFA children were…

  13. Sex-specific responses to vocal convergence and divergence of contact calls in orange-fronted conures (Aratinga canicularis)

    DEFF Research Database (Denmark)

    Balsby, Thorsten J S; Scarl, Judith C

    2008-01-01

    , the similarity between the contact calls of different individuals may either increase (converge) or decrease (diverge). We conducted a playback experiment on wild-caught captive birds in which we simulated convergent, divergent and no-change interaction series with male and female contact calls. OFCs responded...... differently to convergent and divergent series of contact calls, but only when we considered the sex of the test birds. Males called most in response to convergent series, whereas females demonstrated high calling rates in response to both convergent and divergent interactions. Both sexes responded most...... function. The stronger overall response to convergent series suggests that convergence of contact calls is an affiliative signal....

  14. Statistical convergence of order $\\alpha$ in probability

    OpenAIRE

    Pratulananda Das; Sanjoy Ghosal; Sumit Som

    2016-01-01

    In this paper ideas of different types of convergence of a sequence of random variables in probability, namely, statistical convergence of order $\\alpha$ in probability, strong $p$-Ces$\\grave{\\mbox{a}}$ro summability of order $\\alpha$ in probability, lacunary statistical convergence or $S_{\\theta}$-convergence of order $\\alpha$ in probability, ${N_{\\theta}}$-convergence of order $\\alpha$ in probability have been introduced and their certain basic properties have been studied.

  15. Development, reliability, and validity of PRESTO: a new high-variability sentence recognition test.

    Science.gov (United States)

    Gilbert, Jaimie L; Tamati, Terrin N; Pisoni, David B

    2013-01-01

    There is a pressing need for new clinically feasible speech recognition tests that are theoretically motivated, sensitive to individual differences, and access the core perceptual and neurocognitive processes used in speech perception. PRESTO (Perceptually Robust English Sentence Test Open-set) is a new high-variability sentence test designed to reflect current theories of exemplar-based learning, attention, and perception, including lexical organization and automatic encoding of indexical attributes. Using sentences selected from the TIMIT (Texas Instruments/Massachusetts Institute of Technology) speech corpus, PRESTO was developed to include talker and dialect variability. The test consists of lists balanced for talker gender, keywords, frequency, and familiarity. To investigate the performance, reliability, and validity of PRESTO. In Phase I, PRESTO sentences were presented in multitalker babble at four signal-to-noise ratios (SNRs) to obtain a distribution of performance. In Phase II, participants returned and were tested on new PRESTO sentences and on HINT (Hearing In Noise Test) sentences presented in multitalker babble. Young, normal-hearing adults (N = 121) were recruited from the Indiana University community for Phase I. Participants who scored within the upper and lower quartiles of performance in Phase I were asked to return for Phase II (N = 40). In both Phase I and Phase II, participants listened to sentences presented diotically through headphones while seated in enclosed carrels at the Speech Research Laboratory at Indiana University. They were instructed to type in the sentence that they heard using keyboards interfaced to a computer. Scoring for keywords was completed offline following data collection. Phase I data were analyzed by determining the distribution of performance on PRESTO at each SNR and at the average performance across all SNRs. PRESTO reliability was analyzed by a correlational analysis of participant performance at test (Phase I

  16. Validation of high-performance liquid chromatography (HPLC method for quantitative analysis of histamine in fish and fishery products

    Directory of Open Access Journals (Sweden)

    B.K.K.K. Jinadasa

    2016-12-01

    Full Text Available A high-performance liquid chromatography method is described for quantitative determination and validation of histamine in fish and fishery product samples. Histamine is extracted from fish/fishery products by homogenizing with tri-chloro acetic acid, separated with Amberlite CG-50 resin and C18-ODS Hypersil reversed phase column at ambient temperature (25°C. Linear standard curves with high correlation coefficients were obtained. An isocratic elution program was used; the total elution time was 10 min. The method was validated by assessing the following aspects; specificity, repeatability, reproducibility, linearity, recovery, limits of detection, limit of quantification and uncertainty. The validated parameters are in good agreement with method and it is a useful tool for determining histamine in fish and fishery products.

  17. Modelling Iteration Convergence Condition for Single SAR Image Geocoding

    Science.gov (United States)

    Dong, Yuting; Liao, Minghsheng; Zhang, Lu; Shi, Xuguo

    2014-11-01

    Single SAR image geocoding is to determine the ground coordinate for each pixel in the SAR image assisted with an external DEM. Due to the uncertainty of the elevation of each pixel in SAR image, an iterative procedure is needed, which suffers from the problem of divergence in some difficult areas such as shaded and serious layover areas. This paper aims at theoretically analysing the convergence conditions that has not been intensively studied till now. To make the discussion easier, the Range-Doppler (RD) model is simplified and then the general surface is simplified into a planar surface. Mathematical deduction is carried out to derive the convergence conditions and the impact factors for the convergence speed are analysed. The theoretical findings are validated by experiments for both simulated and real surfaces.

  18. A Rapidly Convergence Algorithm for Linear Search and its Application

    Institute of Scientific and Technical Information of China (English)

    Jianliang Li; Hua Zhu; Xianzhong Zhou; Wenjing Song

    2006-01-01

    The essence of the linear search is one-dimension nonlinear minimization problem, which is an important part of the multi-nonlinear optimization, it will be spend the most of operation count for solving optimization problem. To improve the efficiency, we set about from quadratic interpolation, combine the adwantage of the quadratic convergence rate of Newton's method and adopt the idea of Anderson-Bj(o)rck extrapolation, then we present a rapidly convergence algorithm and give its corresponding convergence conclusions. Finally we did the numerical experiments with the some well-known test functions for optimization and the application test of the ANN learning examples. The experiment results showed the validity of the algorithm.

  19. Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function.

    Science.gov (United States)

    Keck, Gary E; Kraft, Matthew B; Truong, Anh P; Li, Wei; Sanchez, Carina C; Kedei, Noemi; Lewin, Nancy E; Blumberg, Peter M

    2008-05-28

    Highly potent bryostatin analogues which contain the complete bryostatin core structure have been synthesized using a pyran annulation approach as a key strategic element. The A ring pyran was assembled using a pyran annulation reaction between a C1-C8 hydroxy allylsilane and an aldehyde comprising C9-C13. This pyran was transformed to a new hydroxy allylsilane and then coupled with a preformed C ring aldehyde subunit in a second pyran annulation, with concomitant formation of the B ring. This tricyclic intermediate was elaborated to bryostatin analogues which displayed nanomolar to subnanomolar affinity for PKC, but displayed properties indistinguishable from a phorbol ester in a proliferation/attachment assay.

  20. Underground verification of the large deflection performance of fibre reinforced shotcrete subjected to high stresses and convergence and to dynamic loading.

    CSIR Research Space (South Africa)

    Joughin, WC

    2002-04-01

    Full Text Available and 25 crosscuts at a depth of 2336m below surface, 71m vertically below reef elevation, approximately 25m horizontally 3 from the shaft pillar abutment. Currently the stress levels are very high due to proximity to the shaft pillar abutment... is sited at Hartebeestfontein 6 shaft pillar, in the 77 level North Haulage, between 24 and 25 crosscuts (Figure 1). It is 2336m below surface, 71m vertically below reef, approximately 25m horizontally from the shaft pillar abutment. Currently...

  1. Digital Convergence and Content Regulation

    NARCIS (Netherlands)

    Starks, Michael John

    2014-01-01

    abstractBroadcasting, Press and Internet journalism systems of distribution are converging: the same infrastructure can deliver all three historically separate services. Reception devices mirror this: the Connected TV, the tablet and the smart phone overlap in their functionality. Service overlaps a

  2. Industrial Evolution Through Complementary Convergence

    DEFF Research Database (Denmark)

    Frøslev Christensen, Jens

    2011-01-01

    The article addresses the dynamics through which product markets become derailed from early product life cycle (PLC)-tracks and engaged in complementary convergence with other product markets or industries. We compare and contrast the theories that can explain, respectively, the PLC...

  3. System Convergence in Transport Modelling

    DEFF Research Database (Denmark)

    Rich, Jeppe; Nielsen, Otto Anker; Cantarella, Guilio E.

    2010-01-01

    -of-successive-averages (MSA) have been proposed. Convergence of the MSA under fairly weak regularity conditions was shown in Robbins and Monro (1951). The iteration between demand and assignment ? the external equilibrium ? are in many models either decoupled or follow a very simple iteration pattern. However, as demand...

  4. Convergence of a Catalan Series

    Science.gov (United States)

    Koshy, Thomas; Gao, Zhenguang

    2012-01-01

    This article studies the convergence of the infinite series of the reciprocals of the Catalan numbers. We extract the sum of the series as well as some related ones, illustrating the power of the calculus in the study of the Catalan numbers.

  5. Converge, Version 3.0

    Directory of Open Access Journals (Sweden)

    Lotfi Tadj

    1993-01-01

    Full Text Available Although intended for college teachers/students, Converge presents a feature that may interest all scientists: it allows an easy export of graphic files to most known word processors, specifically to the ℙ, Version 2.1, a powerful WYSIWYG mathematical word processor.

  6. Exponential convergence rate in entropy

    Institute of Scientific and Technical Information of China (English)

    Mu-Fa Chen

    2007-01-01

    The exponential convergence rate in entropy is studied for symmetric forms, with a specia! attention to the Markov chain with a state space having two points only. Some upper and lower bounds of the rate are obtained and five examples with precise or qualitatively exact estimates are presented.

  7. Convergence analysis of cautious control

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yanxia; GUO Lei

    2006-01-01

    In this paper, we present a theoretical analysis on stability and convergence of the cautious control, which has advantages over the traditional certainty equivalence adaptive control, since it takes the parameter estimation error into account in the design,and is also one-step-ahead optimal in the mean square sense under Gaussian assumptions.

  8. Privatization, convergence, and institutional autonomy

    NARCIS (Netherlands)

    Rooijen, van M.

    2011-01-01

    Some of the trends incoming for 2011 – greater institutional autonomy, public/private convergence, entrepreneurial management, civic engagement – suggest innovation for hard times, with socio-economic and political rationales increasingly driving borderless developments. Others – open learning and h

  9. Financial Development and Convergence Clubs

    NARCIS (Netherlands)

    N. Basturk (Nalan); R. Paap (Richard); D.J.C. van Dijk (Dick)

    2010-01-01

    textabstractThis paper studies the economic development process, measured by Gross Domestic Product (GDP), for a large panel of countries. We propose a methodology that identifies groups of countries (convergence clubs) that show similar GDP structures, while allowing for changes in club membersh

  10. Digital Convergence and Content Regulation

    NARCIS (Netherlands)

    Starks, Michael John

    2014-01-01

    abstractBroadcasting, Press and Internet journalism systems of distribution are converging: the same infrastructure can deliver all three historically separate services. Reception devices mirror this: the Connected TV, the tablet and the smart phone overlap in their functionality. Service overlaps

  11. Validation and application of an high-order spectral difference method for flow induced noise simulation

    KAUST Repository

    Parsani, Matteo

    2011-09-01

    The main goal of this paper is to develop an efficient numerical algorithm to compute the radiated far field noise provided by an unsteady flow field from bodies in arbitrary motion. The method computes a turbulent flow field in the near fields using a high-order spectral difference method coupled with large-eddy simulation approach. The unsteady equations are solved by advancing in time using a second-order backward difference formulae scheme. The nonlinear algebraic system arising from the time discretization is solved with the nonlinear lowerupper symmetric GaussSeidel algorithm. In the second step, the method calculates the far field sound pressure based on the acoustic source information provided by the first step simulation. The method is based on the Ffowcs WilliamsHawkings approach, which provides noise contributions for monopole, dipole and quadrupole acoustic sources. This paper will focus on the validation and assessment of this hybrid approach using different test cases. The test cases used are: a laminar flow over a two-dimensional (2D) open cavity at Re = 1.5 × 10 3 and M = 0.15 and a laminar flow past a 2D square cylinder at Re = 200 and M = 0.5. In order to show the application of the numerical method in industrial cases and to assess its capability for sound field simulation, a three-dimensional turbulent flow in a muffler at Re = 4.665 × 10 4 and M = 0.05 has been chosen as a third test case. The flow results show good agreement with numerical and experimental reference solutions. Comparison of the computed noise results with those of reference solutions also shows that the numerical approach predicts noise accurately. © 2011 IMACS.

  12. Widespread convergence in toxin resistance by predictable molecular evolution

    OpenAIRE

    Ujvari, Beata; Casewell, Nicholas R.; Sunagar, Kartik; Arbuckle, Kevin; Wüster, Wolfgang; Lo, Nathan; O’Meally, Denis; Beckmann, Christa; King, Glenn F.; Deplazes, Evelyne; Madsen, Thomas

    2015-01-01

    Convergence has strong bearing on the fundamental debate about whether evolution is stochastic and unpredictable or subject to constraints. Here we show that, in certain circumstances, evolution can be highly predictable. We demonstrate that several lineages of insects, amphibians, reptiles, and mammals have utilized the same molecular solution, via the process of convergence, to evolve resistance to toxic cardiac glycosides produced defensively by plants and bufonid toads. The repeatability ...

  13. A Short Study on the Validity of Miller's Theorem Applied to Transistor Amplifier High-Frequency Performance

    Science.gov (United States)

    Schubert, T. F., Jr.; Kim, E. M.

    2009-01-01

    The use of Miller's Theorem in the determination of the high-frequency cutoff frequency of transistor amplifiers was recently challenged by a paper published in this TRANSACTIONS. Unfortunately, that paper provided no simulation or experimental results to bring credence to the challenge or to validate the alternate method of determination…

  14. Development and Validation of the Learning Progression-Based Assessment of Modern Genetics in a High School Context

    Science.gov (United States)

    Todd, Amber; Romine, William L.; Cook Whitt, Katahdin

    2017-01-01

    We describe the development, validation, and use of the "Learning Progression-Based Assessment of Modern Genetics" (LPA-MG) in a high school biology context. Items were constructed based on a current learning progression framework for genetics (Shea & Duncan, 2013; Todd & Kenyon, 2015). The 34-item instrument, which was tied to…

  15. Differential Predictive Validity of High School GPA and College Entrance Test Scores for University Students in Yemen

    Science.gov (United States)

    Al-Hattami, Abdulghani Ali Dawod

    2012-01-01

    High school grade point average and college entrance test scores are two admission criteria that are currently used by most colleges in Yemen to select their prospective students. Given their widespread use, it is important to investigate their predictive validity to ensure the accuracy of the admission decisions in these institutions. This study…

  16. A Short Study on the Validity of Miller's Theorem Applied to Transistor Amplifier High-Frequency Performance

    Science.gov (United States)

    Schubert, T. F., Jr.; Kim, E. M.

    2009-01-01

    The use of Miller's Theorem in the determination of the high-frequency cutoff frequency of transistor amplifiers was recently challenged by a paper published in this TRANSACTIONS. Unfortunately, that paper provided no simulation or experimental results to bring credence to the challenge or to validate the alternate method of determination…

  17. Differential Predictive Validity of High School GPA and College Entrance Test Scores for University Students in Yemen

    Science.gov (United States)

    Al-Hattami, Abdulghani Ali Dawod

    2012-01-01

    High school grade point average and college entrance test scores are two admission criteria that are currently used by most colleges in Yemen to select their prospective students. Given their widespread use, it is important to investigate their predictive validity to ensure the accuracy of the admission decisions in these institutions. This study…

  18. Is Learner Self-Assessment Reliable and Valid in a Web-Based Portfolio Environment for High School Students?

    Science.gov (United States)

    Chang, Chi-Cheng; Liang, Chaoyun; Chen, Yi-Hui

    2013-01-01

    This study explored the reliability and validity of Web-based portfolio self-assessment. Participants were 72 senior high school students enrolled in a computer application course. The students created learning portfolios, viewed peers' work, and performed self-assessment on the Web-based portfolio assessment system. The results indicated: 1)…

  19. Validation of a Portuguese Version of the Snyder Hope Scale in a Sample of High School Students

    Science.gov (United States)

    Marques, Susana C.; Lopez, Shane J.; Fontaine, Anne Marie; Coimbra, Susana; Mitchell, Joanna

    2014-01-01

    C. R. Snyder conceptualized hope as a cognitive construct that reflects people's motivation and capacity to strive toward personally relevant goals. Using this definition, Snyder and colleagues developed and validated the Hope Scale (HS). This study is the first study to examine the psychometric properties of the HS in a sample of high school…

  20. An Assessment of the Social Validity of Cooperative Learning and Conflict Resolution Programs in an Alternative Inner City High School.

    Science.gov (United States)

    Khattri, Nidhi

    A study was done to evaluate the social validity of the interventions of conflict resolution and cooperative learning at three campuses of an alternative inner-city high school in New York City. The evaluation explored students' and teachers' perceptions of the effectiveness and applicability of the interventions in their lives. Extensive…

  1. The development and validation of two prediction models to identify employees at risk of high sickness absence

    NARCIS (Netherlands)

    Roelen, Corne A.; van Rhenen, Willem; Groothoff, Johan W.; van der Klink, Jac J.; Bultmann, Ute; Heymans, Martijn W.

    Background: Sickness absence (SA) is a public health risk marker for morbidity and mortality. The aim of this study was to develop and validate prediction models to identify employees at risk of high SA. Methods: Two prediction models were developed using self-rated health (SRH) and prior SA as

  2. An Airborne Observing Campaign of an Announced Small Asteroid Impact for High Fidelity Impact Modeling Validation

    Science.gov (United States)

    Jenniskens, P. M. M.; Grinstead, J. H.

    2015-12-01

    High fidelity modeling of an asteroid impact requires a known size, mass, shape, entry orientation, entry speed, entry angle, time and location of entry, and material properties of the impacting asteroid. Much of that information can be gathered from small asteroids on an impact trajectory with Earth while they are on approach, given sufficient warning time. That makes small asteroid impacts uniquely suited for collecting data to validate such models. One-meter sized asteroids impact Earth about once a week, 4-meter sized asteroids impact once a year. So far, only asteroid 2008 TC3 was observed in space, characterized prior to impact, and then recovered in part as meteorites on the ground. The next TC3-like impact could provide more warming time to study the impact in detail. Close to 70 percent of all asteroid impacts on Earth occur over the ocean. Hence, small asteroid impact observations require an instrumented airborne platform to take a multi-disciplined research team to the right location at the right time. From a safe 100-km distance, the impact would be observed low enough in the sky to study the process of fragmentation that dictates at which altitude the kinetic energy is deposited that can cause an airburst. Constraints on radiative heating, ablation rate, and fragmentation processes can be obtained from measuring the air plasma emission escaping the shock, elemental atom line emissions and excitation conditions, pressure broadening, and deceleration in the plane of the known trajectory. It is also possible to measure wake, lightcurve and air plasma emission line intensities early in flight that can be used to evaluate the presence of regolith and the internal cohesion of asteroids. The main element abundance (asteroid composition) can be measured for individual fragments, while CN-band emission can point to the presence of organic matter. Such information will help constrain the meteorite type if no meteorites can be recovered in an over

  3. Validation of the Metacomprehension Scale

    Science.gov (United States)

    Moore; Zabrucky; Commander

    1997-10-01

    Evidence for the factorial, convergent and discriminant, and criterion-related validity of the Metacomprehension Scale (MCS) was examined in a sample of 237 young adults. The instrument was factorially heterogeneous but exhibited homogeneity within each of the seven subscales. Evidence for the convergent and discriminant validity of the MCS was examined by correlating the subscales from the MCS with subscales from metacognitive questionnaires measuring similar constructs from related domains. In general, correlations within constructs were larger than correlations between constructs, providing preliminary evidence of the convergent and discriminant validity of the MCS. The criterion-related validity of the MCS relative to other metacognitive measures was examined by using the metacognitive measures and the MCS to predict comprehension performance. The MCS predicted performance better than the other measures of metacognition and accounted for variance in performance not accounted for by the other measures. These results show promise for the value of self-assessments of metacomprehension. Copyright 1997Academic Press

  4. Regulatory perspectives on model validation in high-level radioactive waste management programs: A joint NRC/SKI white paper

    Energy Technology Data Exchange (ETDEWEB)

    Wingefors, S.; Andersson, J.; Norrby, S. [Swedish Nuclear Power lnspectorate, Stockholm (Sweden). Office of Nuclear Waste Safety; Eisenberg, N.A.; Lee, M.P.; Federline, M.V. [U.S. Nuclear Regulatory Commission, Washington, DC (United States). Office of Nuclear Material Safety and Safeguards; Sagar, B.; Wittmeyer, G.W. [Center for Nuclear Waste Regulatory Analyses, San Antonio, TX (United States)

    1999-03-01

    Validation (or confidence building) should be an important aspect of the regulatory uses of mathematical models in the safety assessments of geologic repositories for the disposal of spent nuclear fuel and other high-level radioactive wastes (HLW). A substantial body of literature exists indicating the manner in which scientific validation of models is usually pursued. Because models for a geologic repository performance assessment cannot be tested over the spatial scales of interest and long time periods for which the models will make estimates of performance, the usual avenue for model validation- that is, comparison of model estimates with actual data at the space-time scales of interest- is precluded. Further complicating the model validation process in HLW programs are the uncertainties inherent in describing the geologic complexities of potential disposal sites, and their interactions with the engineered system, with a limited set of generally imprecise data, making it difficult to discriminate between model discrepancy and inadequacy of input data. A successful strategy for model validation, therefore, should attempt to recognize these difficulties, address their resolution, and document the resolution in a careful manner. The end result of validation efforts should be a documented enhancement of confidence in the model to an extent that the model's results can aid in regulatory decision-making. The level of validation needed should be determined by the intended uses of these models, rather than by the ideal of validation of a scientific theory. This white Paper presents a model validation strategy that can be implemented in a regulatory environment. It was prepared jointly by staff members of the U.S. Nuclear Regulatory Commission and the Swedish Nuclear Power Inspectorate-SKI. This document should not be viewed as, and is not intended to be formal guidance or as a staff position on this matter. Rather, based on a review of the literature and previous

  5. Convergence

    DEFF Research Database (Denmark)

    Madsen, Ole Brun; Nielsen, Jens Frederik Dalsgaard; Schiøler, Henrik

    2002-01-01

    with the emergence of remote service provision, such as supervision and control of decentralized heating facilities and wind based electrical power production. The reliability issue is addressed from a structural viewpoint, where the concept of Structural QoS (SQoS) is defined to support reliability modelling...... in communication infrastructures. A graph theoretical approach is presented as an approach to reliability management in complex communication infrastructures. Real life examples are provided and specific problems are presented and discussed. Wireless technologies are discussed as a complement, providing not only...

  6. convergence

    Directory of Open Access Journals (Sweden)

    Nikolai Kolev

    2003-01-01

    placing n labeled balls into N labeled cells. We study the asymptotic behavior of the number of empty cells when (n,N belongs to the “right” and “left” domain of attraction. An application to the estimation of characteristics of agreement among a set of raters which independently classify subjects into one of two categories is also indicated. The case when a large number of raters acts following the zero-inflated binomial law with small probability for positive diagnosis is treated using the zero-inflated Poisson approximation.

  7. Quantifying convergence in the sciences

    Directory of Open Access Journals (Sweden)

    Sara Lumbreras

    2016-02-01

    Full Text Available Traditional epistemological models classify knowledge into separate disciplines with different objects of study and specific techniques, with some frameworks even proposing hierarchies (such as Comte’s. According to thinkers such as John Holland or Teilhard de Chardin, the advancement of science involves the convergence of disciplines. This proposed convergence can be studied in a number of ways, such as how works impact research outside a specific area (citation networks or how authors collaborate with other researchers in different fields (collaboration networks. While these studies are delivering significant new insights, they cannot easily show the convergence of different topics within a body of knowledge. This paper attempts to address this question in a quantitative manner, searching for evidence that supports the idea of convergence in the content of the sciences themselves (that is, whether the sciences are dealing with increasingly the same topics. We use Latent Dirichlet Analysis (LDA, a technique that is able to analyze texts and estimate the relative contributions of the topics that were used to generate them. We apply this tool to the corpus of the Santa Fe Institute (SFI working papers, which spans research on Complexity Science from 1989 to 2015. We then analyze the relatedness of the different research areas, the rise and demise of these sub-disciplines over time and, more broadly, the convergence of the research body as a whole. Combining the topic structure obtained from the collected publication history of the SFI community with techniques to infer hierarchy and clustering, we reconstruct a picture of a dynamic community which experiences trends, periodically recurring topics, and shifts in the closeness of scholarship over time. We find that there is support for convergence, and that the application of quantitative methods such as LDA to the study of knowledge can provide valuable insights that can help

  8. Convergent Validity of O*NET Holland Code Classifications

    Science.gov (United States)

    Eggerth, Donald E.; Bowles, Shannon M.; Tunick, Roy H.; Andrew, Michael E.

    2005-01-01

    The interpretive ease and intuitive appeal of the Holland RIASEC typology have made it nearly ubiquitous in vocational guidance settings. Its incorporation into the Occupational Information Network (O*NET) has moved it another step closer to reification. This research investigated the rates of agreement between Holland code classifications from…

  9. Overview of results of the first phase of validation activities for the IFMIF High Flux Test Module

    Energy Technology Data Exchange (ETDEWEB)

    Arbeiter, Frederik, E-mail: frederik.arbeiter@kit.edu [Karlsruhe Institute of Technology, Karlsruhe (Germany); Chen Yuming; Dolensky, Bernhard; Freund, Jana; Heupel, Tobias; Klein, Christine; Scheel, Nicola; Schlindwein, Georg [Karlsruhe Institute of Technology, Karlsruhe (Germany)

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer Validation of computational fluid dynamics (CFD) modeling approach for application in the IFMIF High Flux Test Module. Black-Right-Pointing-Pointer Fabrication of prototypes of the irradiation capsules of the IFMIF High Flux Test Module. - Abstract: The international fusion materials irradiation facility (IFMIF) is projected to create an experimentally validated database of material properties relevant for fusion reactor designs. The IFMIF High Flux Test Module is the dedicated experiment to irradiate alloys in the temperature range 250-550 Degree-Sign C and up to 50 displacements per atom per irradiation cycle. The High Flux Test Module is developed to maximize the specimen payload in the restricted irradiation volume, and to minimize the temperature spread within each specimen bundle. Low pressure helium mini-channel cooling is used to offer a high integration density. Due to the demanding thermo-hydraulic and mechanical conditions, the engineering design process (involving numerical neutronic, thermo-hydraulic and mechanical analyses) is supported by extensive experimental validation activities. This paper reports on the prototype manufacturing, thermo-hydraulic modeling experiments and component tests, as well as on mechanical testing. For the testing of the 1:1 prototype of the High Flux Test Module, a dedicated test facility, the Helium Loop Karlsruhe-Low Pressure (HELOKA-LP) has been taken into service.

  10. Convergent sequence evolution between echolocating bats and dolphins.

    Science.gov (United States)

    Liu, Yang; Cotton, James A; Shen, Bin; Han, Xiuqun; Rossiter, Stephen J; Zhang, Shuyi

    2010-01-26

    Cases of convergent evolution - where different lineages have evolved similar traits independently - are common and have proven central to our understanding of selection. Yet convincing examples of adaptive convergence at the sequence level are exceptionally rare [1]. The motor protein Prestin is expressed in mammalian outer hair cells (OHCs) and is thought to confer high frequency sensitivity and selectivity in the mammalian auditory system [2]. We previously reported that the Prestin gene has undergone sequence convergence among unrelated lineages of echolocating bat [3]. Here we report that this gene has also undergone convergent amino acid substitutions in echolocating dolphins, which group with echolocating bats in a phylogenetic tree of Prestin. Furthermore, we find evidence that these changes were driven by natural selection.

  11. Testing and validation of high density resequencing microarray for broad range biothreat agents detection.

    Directory of Open Access Journals (Sweden)

    Tomasz A Leski

    Full Text Available Rapid and effective detection and identification of emerging microbiological threats and potential biowarfare agents is very challenging when using traditional culture-based methods. Contemporary molecular techniques, relying upon reverse transcription and/or polymerase chain reaction (RT-PCR/PCR provide a rapid and effective alternative, however, such assays are generally designed and optimized to detect only a limited number of targets, and seldom are capable of differentiation among variants of detected targets. To meet these challenges, we have designed a broad-range resequencing pathogen microarray (RPM for detection of tropical and emerging infectious agents (TEI including biothreat agents: RPM-TEI v 1.0 (RPM-TEI. The scope of the RPM-TEI assay enables detection and differential identification of 84 types of pathogens and 13 toxin genes, including most of the class A, B and C select agents as defined by the Centers for Disease Control and Prevention (CDC, Atlanta, GA. Due to the high risks associated with handling these particular target pathogens, the sensitivity validation of the RPM-TEI has been performed using an innovative approach, in which synthetic DNA fragments are used as templates for testing the assay's limit of detection (LOD. Assay specificity and sensitivity was subsequently confirmed by testing with full-length genomic nucleic acids of selected agents. The LOD for a majority of the agents detected by RPM-TEI was determined to be at least 10(4 copies per test. Our results also show that the RPM-TEI assay not only detects and identifies agents, but is also able to differentiate near neighbors of the same agent types, such as closely related strains of filoviruses of the Ebola Zaire group, or the Machupo and Lassa arenaviruses. Furthermore, each RPM-TEI assay results in specimen-specific agent gene sequence information that can be used to assess pathogenicity, mutations, and virulence markers, results that are not generally

  12. Filopodial-Tension Model of Convergent-Extension of Tissues.

    Directory of Open Access Journals (Sweden)

    Julio M Belmonte

    2016-06-01

    Full Text Available In convergent-extension (CE, a planar-polarized epithelial tissue elongates (extends in-plane in one direction while shortening (converging in the perpendicular in-plane direction, with the cells both elongating and intercalating along the converging axis. CE occurs during the development of most multicellular organisms. Current CE models assume cell or tissue asymmetry, but neglect the preferential filopodial activity along the convergent axis observed in many tissues. We propose a cell-based CE model based on asymmetric filopodial tension forces between cells and investigate how cell-level filopodial interactions drive tissue-level CE. The final tissue geometry depends on the balance between external rounding forces and cell-intercalation traction. Filopodial-tension CE is robust to relatively high levels of planar cell polarity misalignment and to the presence of non-active cells. Addition of a simple mechanical feedback between cells fully rescues and even improves CE of tissues with high levels of polarity misalignments. Our model extends easily to three dimensions, with either one converging and two extending axes, or two converging and one extending axes, producing distinct tissue morphologies, as observed in vivo.

  13. Proliferating Connections and Communicating Convergence

    Directory of Open Access Journals (Sweden)

    Aylish Wood

    2008-01-01

    Full Text Available In this paper I use the work of Niklas Luhmann to explore what pressure the concept of convergence exerts over how we communicate about the changing expressive practices of digital games following the emergence of digital technologies. My claim will be that in its current form, convergence privileges either the human users of technological platforms, or the combination of aesthetic conventions from different media what connects is either the user or the aesthetic code. While neither of these two positions would be likely to deny a reliance on the interplay between humans and technologies, such an interplay is taken for granted rather than explored. By using Luhmann’s version of systems theory, I argue that we can more effectively grasp the interplay of human and technological participants by understanding their combined roles in changing expressive practices.

  14. Concept Convergence in Empirical Domains

    Science.gov (United States)

    Ontañón, Santiago; Plaza, Enric

    How to achieve shared meaning is a significant issue when more than one intelligent agent is involved in the same domain. We define the task of concept convergence, by which intelligent agents can achieve a shared, agreed-upon meaning of a concept (restricted to empirical domains). For this purpose we present a framework that, integrating computational argumentation and inductive concept learning, allows a pair of agents to (1) learn a concept in an empirical domain, (2) argue about the concept's meaning, and (3) reach a shared agreed-upon concept definition. We apply this framework to marine sponges, a biological domain where the actual definitions of concepts such as orders, families and species are currently open to discussion. An experimental evaluation on marine sponges shows that concept convergence is achieved, within a reasonable number of interchanged arguments, and reaching short and accurate definitions (with respect to precision and recall).

  15. Questioning the Validity of Inquiry Assessment in a High Stakes Physical Sciences Examination

    Science.gov (United States)

    Ramnarain, Umesh

    2014-01-01

    The South African science curriculum advocates an inquiry-based approach to practical work. Inquiry is a complex and multifaceted activity involving both cognitive and physical activity; thus, paper-and-pencil items do not provide the authentic context for this assessment. This study investigates the construct validity of inquiry-related questions…

  16. Screening High School Students for Eating Disorders: Validity of Brief Behavioral and Attitudinal Measures

    Science.gov (United States)

    Haines, Jess; Ziyadeh, Najat J.; Franko, Debra L.; McDonald, Julia; Mond, Jonathan M.; Austin, S. Bryn

    2011-01-01

    Background: Early identification can greatly impact the trajectory of eating disorders, and school-based screening is 1 avenue for identifying those at risk. To be feasible in a school setting, a screening program must use a brief, valid screening tool. The aim of this study was to assess how well brief attitudinal and behavioral survey items…

  17. Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas

    DEFF Research Database (Denmark)

    Øster, Bodil; Thorsen, Kasper; Lamy, Philippe;

    2011-01-01

    .005). Identified hypermethylated sites were validated in an independent sample set of eight normal mucosas, 12 adenomas, 40 MSS and nine MSI cancer samples. The methylation patterns of 15 selected genes, hypermethylated in adenomas and carcinomas (FLI1, ST6GALNAC5, TWIST1, ADHFE1, JAM2, IRF4, CNRIP1, NRG1, and EYA...

  18. Development and Validation of an Instrument for Assessing Attitudes of High School Students about Recycling

    Science.gov (United States)

    Ugulu, Ilker

    2015-01-01

    Recycling and its applications are growing significantly due to the great potential for solving a range of environmental problems in society. Nevertheless, there are currently very few instruments that can provide valid and reliable data on students' attitudes toward recycling. In this regard, this article focuses on the development and validation…

  19. Psychometric Validation of the Chinese Compulsive Internet Use Scale (CIUS) with Taiwanese High School Adolescents.

    Science.gov (United States)

    Dhir, Amandeep; Chen, Sufen; Nieminen, Marko

    2015-12-01

    The recent development of internet infrastructure has fuelled a popular concern that young Asian internet users are experiencing Internet addiction due to excessive Internet use. In order to understand the phenomenon, psychometric validation of a 14-item Compulsive Internet Use Scale (CIUS), with 417 Chinese adolescents has been performed. Compared to other instruments for use with Chinese populations, e.g. the 20-item Internet Addiction Test (IAT) and the 26-item Chen Internet Addiction Scale, the CIUS is relatively concise, and easy to use for measuring and diagnosing Internet addiction. The present psychometric validation has found good factorial stability with a one-factor solution for the CIUS. The internal consistency and model fit indices were very good, and even better than any previous CIUS validations. The Chinese CIUS is a valid and reliable self-reporting instrument for examining compulsive Internet use among Chinese adolescents. Other findings included: male adolescents tend to experience more compulsive Internet use than their female counterparts, and CIUS scores were positively correlated with the daily Internet use time and negatively correlated with the academic performance of the participants. No significant relationships between the CIUS, ICT accessibility, family economic condition, parental occupation or religion were found.

  20. Validation of a method for accurate and highly reproducible quantification of brain dopamine transporter SPECT studies

    DEFF Research Database (Denmark)

    Jensen, Peter S; Ziebell, Morten; Skouboe, Glenna

    2011-01-01

    In nuclear medicine brain imaging, it is important to delineate regions of interest (ROIs) so that the outcome is both accurate and reproducible. The purpose of this study was to validate a new time-saving algorithm (DATquan) for accurate and reproducible quantification of the striatal dopamine...... transporter (DAT) with appropriate radioligands and SPECT and without the need for structural brain scanning....

  1. Validity of Suicidality Items from the Youth Risk Behavior Survey in a High School Sample

    Science.gov (United States)

    May, Alexis; Klonsky, E. David

    2011-01-01

    The Youth Risk Behavior Survey (YRBS) is used by the United States Centers for Disease Control to estimate rates of suicidal thoughts and behaviors in adolescents. This study investigated the validity of the YRBS suicidality items by examining their relationship to criterion variables including loneliness, anxiety, depression, substance use, and…

  2. Optimality Functions and Lopsided Convergence

    Science.gov (United States)

    2015-03-16

    Problems involving functions defined in terms of integrals or optimization problems (as the maxi - mization in Example 3), functions defined on infinite...optimization methods in finite time. The key technical challenge associate with the above scheme is to establish ( weak ) consistency. In the next...Theorem 4.3. In view of this result, it is clear that ( weak ) consistency will be ensured by epi-convergence of the approximating objective functions and

  3. ACCOUNTING CONVERGENCE ON ECONOMIC CRISIS

    Directory of Open Access Journals (Sweden)

    HOLBAN ONCIOIU IONICA

    2010-12-01

    Full Text Available If normalization accounting is the process of harmonizing the presentation of financial statements, accounting methods and terminology, accounting convergence is the process by which accounting standards are developed in a way that is able to lead to the same fact or purpose, by highlighting the similarity of national - regional - international. This paper put in light the importance of the normalization and harmonization process, what its done in and what we have to do for that in Romania.

  4. Exponentially Convergent Algorithms for Abstract Differential Equations

    CERN Document Server

    Gavrilyuk, Ivan; Vasylyk, Vitalii

    2011-01-01

    This book presents new accurate and efficient exponentially convergent methods for abstract differential equations with unbounded operator coefficients in Banach space. These methods are highly relevant for the practical scientific computing since the equations under consideration can be seen as the meta-models of systems of ordinary differential equations (ODE) as well as the partial differential equations (PDEs) describing various applied problems. The framework of functional analysis allows one to obtain very general but at the same time transparent algorithms and mathematical results which

  5. Convergences and divergences in mortality

    Directory of Open Access Journals (Sweden)

    2004-04-01

    Full Text Available Abdel Omran's 1971 theory of "Epidemiologic Transition" was the first attempt to account for the extraordinary advances in health care made in industrialized countries since the 18th century. In the framework of the Demographic Transition, it implied a general convergence of life expectancies toward a limit imposed by the new epidemiological features of modern societies. However, important failures, occurred in the past decades (mainly the health crisis in Eastern Europe and AIDS in Africa, seem to have stopped that process of convergence. In fact such failures do not really contradict the theory. The latter is much more ruined by the unexpected dramatic improvement in the field of cardiovascular disease experienced since the seventies, which results in a new step of a more general process. On the basis of the broader concept of "Health Transition" initiated by Julio Frenk et al., the present paper tries to rethink the full process in term of divergence/convergence sequences inferred by successive major changes in health technologies and strategies.

  6. A globally convergent matricial algorithm for multivariate spectral estimation

    CERN Document Server

    Ramponi, Federico; Pavon, Michele

    2008-01-01

    In this paper, we first describe a matricial Newton-type algorithm designed to solve the multivariable spectrum approximation problem. We then prove its global convergence. Finally, we apply this approximation procedure to multivariate spectral estimation, and test its effectiveness through simulation. Simulation shows that, in the case of short observation records, this method may provide a valid alternative to standard multivariable identification techniques such as MATLAB's PEM and MATLAB's N4SID.

  7. Design description and validation results for the IFMIF High Flux Test Module as outcome of the EVEDA phase

    Directory of Open Access Journals (Sweden)

    F. Arbeiter

    2016-12-01

    Full Text Available During the Engineering Validation and Engineering Design Activities (EVEDA phase (2007-2014 of the International Fusion Materials Irradiation Facility (IFMIF, an advanced engineering design of the High Flux Test Module (HFTM has been developed with the objective to facilitate the controlled irradiation of steel samples in the high flux area directly behind the IFMIF neutron source. The development process addressed included manufacturing techniques, CAD, neutronic, thermal-hydraulic and mechanical analyses complemented by a series of validation activities. Validation included manufacturing of 1:1 parts and mockups, test of prototypes in the FLEX and HELOKA-LP helium loops of KIT for verification of the thermal and mechanical properties, and irradiation of specimen filled capsule prototypes in the BR2 test reactor. The prototyping activities were backed by several R&D studies addressing focused issues like handling of liquid NaK (as filling medium and insertion of Small Specimen Test Technique (SSTT specimens into the irradiation capsules. This paper provides an up-todate design description of the HFTM irradiation device, and reports on the achieved performance criteria related to the requirements. Results of the validation activities are accounted for and the most important issues for further development are identified.

  8. Prospective validation of text categorization filters for identifying high-quality, content-specific articles in MEDLINE.

    Science.gov (United States)

    Aphinyanaphongs, Yindalon; Aliferis, Constantin

    2006-01-01

    In prior work, we introduced a machine learning method to identify high quality MEDLINE documents in internal medicine. The performance of the original filter models built with this corpus on years outside 1998-2000 was not assessed directly. Validating the performance of the original filter models on current corpora is crucial to validate them for use in current years, to verify that the model fitting and model error estimation procedures do not over-fit the models, and to validate consistency of the chosen ACPJ gold standard (i.e., that ACPJ editorial policies and criteria are stable over time). Our prospective validation results indicated that in the categories of treatment, etiology, diagnosis, and prognosis, the original machine learning filter models built from the 1998-2000 corpora maintained their discriminatory performance of 0.97, 0.97, 0.94, and 0.94 area under the curve in each respective category when applied to a 2005 corpus. The ACPJ is a stable, reliable gold standard and the machine learning methodology provides robust models and model performance estimates. Machine learning filter models built with 1998-2000 corpora can be applied to identify high quality articles in recent years.

  9. CONVERGENCE THEOREMS FOR THE AOR METHOD

    Institute of Scientific and Technical Information of China (English)

    黄廷祝; 王广彬

    2002-01-01

    Practical sufficient conditions for the convergence of the AOR method and a practical sufficient condition for H-matrices are studied. The obtained convergence conditions suited to matrices which need not to be diagonally dominant.

  10. User Configurations and Convergence in Consumer Electronics

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik

    2000-01-01

    Convergence has been a technical fix motivated by the digital developments in media technologies.......Convergence has been a technical fix motivated by the digital developments in media technologies....

  11. Data from the Dialysis Outcomes and Practice Patterns Study validate an association between high intravenous iron doses and mortality.

    Science.gov (United States)

    Bailie, George R; Larkina, Maria; Goodkin, David A; Li, Yun; Pisoni, Ronald L; Bieber, Brian; Mason, Nancy; Tong, Lin; Locatelli, Francesco; Marshall, Mark R; Inaba, Masaaki; Robinson, Bruce M

    2015-01-01

    Intravenous (IV) iron is required for optimal management of anemia in the majority of hemodialysis (HD) patients. While IV iron prescription has increased over time, the best dosing strategy is unknown and any effect of IV iron on survival is unclear. Here we used adjusted Cox regression to analyze associations between IV iron dose and clinical outcomes in 32,435 HD patients in 12 countries from 2002 to 2011 in the Dialysis Outcomes and Practice Patterns Study. The primary exposure was total prescribed IV iron dose over the first 4 months in the study, expressed as an average dose/month. Compared with 100-199 mg/month (the most common dose range), case-mix-adjusted mortality was similar for the 0, 1-99, and 200-299 mg/month categories but significantly higher for the 300-399 mg/month (HR of 1.13, 95% CI of 1.00-1.27) and 400 mg/month or more (HR of 1.18, 95% CI of 1.07-1.30) groups. Convergent validity was proved by an instrumental variable analysis, using HD facility as the instrument, and by an analysis expressing IV iron dose/kg body weight. Associations with cause-specific mortality (cardiovascular, infectious, and other) were generally similar to those for all-cause mortality. The hospitalization risk was elevated among patients receiving 300 mg/month or more compared with 100-199 mg/month (HR of 1.12, 95% CI of 1.07-1.18). In light of these associations, a well-powered clinical trial to evaluate the safety of different IV iron-dosing strategies in HD patients is urgently needed.

  12. Instability and Tsunamigenic Potential at Convergent Margins

    Science.gov (United States)

    von Huene, R.; Ranero, C. R.; Watts, P.

    2001-12-01

    Along many convergent margins multibeam echosounding navigated with GPS has revealed large slope failures that were probably tsunamigenic. Bathymetric data combined with seismic reflection imaging indicate multiple causes. The 55-km wide Nicoya Slump resulted from the steepening slope above an underthrusting seamount on the subducting oceanic plate. This slump may have generated a 27-m high wave. Several 5-7 km wide mid-slope slides off central Nicaragua probably resulted from steepening of the continental slope by tectonic erosion. They may have generated waves 6-7 m high. A 30 km wide mid-slope slump off northern Peru may have generated a 5 m high wave. Its cause will not be understood without better seismic reflection imaging but considerable fluid venting was observed across its headwall. In the Gulf of Alaska a large slide appears to have resulted from rapid sedimentation. Tsunamigenic slope failure along convergent margins is only beginning to be resolved and the causes vary. Subducted ocean floor relief, tectonically steepened slopes, and sites of rapid sedimentation can help target potential failure and possible future tsunami hazards.

  13. Fiscal Convergence in an Enlarged European Union

    Directory of Open Access Journals (Sweden)

    Georgeta VINTILĂ

    2014-02-01

    Full Text Available Taxation convergence in the European Union has always been a heatedly debated issue, and it has constantly resurfaced to the limelight as more and more fiscal directive proposals are being discussed. The current study is an analysis of the evolution of taxation convergence tendencies within the European Union in recent years, using sigma-convergence and cluster analysis. Our goal is to analyze the fiscal convergence trends in the context of European Union enlargement over the last two decades.

  14. Convergence of barycentric coordinates to barycentric kernels

    KAUST Repository

    Kosinka, Jiří

    2016-02-12

    We investigate the close correspondence between barycentric coordinates and barycentric kernels from the point of view of the limit process when finer and finer polygons converge to a smooth convex domain. We show that any barycentric kernel is the limit of a set of barycentric coordinates and prove that the convergence rate is quadratic. Our convergence analysis extends naturally to barycentric interpolants and mappings induced by barycentric coordinates and kernels. We verify our theoretical convergence results numerically on several examples.

  15. Translation, Cultural Adaptation and Validation of the Questionnaire on Teacher Interaction in Danish High Schools

    DEFF Research Database (Denmark)

    Lund, Lea; Cozart, Stacey Marie; Lyneborg Lund, Rolf

    2017-01-01

    the interaction with their teachers. The QTI has been shown to be a valid and reliable instrument in all the different language versions in which it was adapted. The QTI with the 64-item version has not yet received a validation in Denmark. The present study tested the translation process – after the translation...... the psychometric properties of the Danish translation of the QTI in its 64-item version. The article is descriptive and stress the importance of the awareness of the cultural differences when translating and incorporating a questionnaire from one country’s educational setting to another. Results on the approach...... to translation and cultural adaption showed the importance of the dialogical process with informants to make sure the questions are sound and understood in correlation to the MITB model....

  16. High precision EPR dosimetry as a reference tool for validation of other techniques.

    Science.gov (United States)

    Chumak, V V; Sholom, S V; Bakhanova, E V; Pasalskaya, L F; Musijachenko, A V

    2005-02-01

    We present here a particular application area for EPR dosimetry with teeth--use as a source of reference dose values for validation/verification of other retrospective dosimetry techniques and existing dose records. The conditions of application of EPR dosimetry in this role as well as practical design of such studies are shown. Particular attention is given to the requirements to the techniques in terms of precision and throughput, as well as to the issue of availability of samples for analysis and practical solution of this problem. Practical application of this approach is illustrated by several examples of completed validation sub-studies, which were performed in the framework of large-scale post-Chernobyl epidemiological studies.

  17. High-resolution computational algorithms for simulating offshore wind turbines and farms: Model development and validation

    Energy Technology Data Exchange (ETDEWEB)

    Calderer, Antoni [Univ. of Minnesota, Minneapolis, MN (United States); Yang, Xiaolei [Stony Brook Univ., NY (United States); Angelidis, Dionysios [Univ. of Minnesota, Minneapolis, MN (United States); Feist, Chris [Univ. of Minnesota, Minneapolis, MN (United States); Guala, Michele [Univ. of Minnesota, Minneapolis, MN (United States); Ruehl, Kelley [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Guo, Xin [Univ. of Minnesota, Minneapolis, MN (United States); Boomsma, Aaron [Univ. of Minnesota, Minneapolis, MN (United States); Shen, Lian [Univ. of Minnesota, Minneapolis, MN (United States); Sotiropoulos, Fotis [Stony Brook Univ., NY (United States)

    2015-10-30

    The present project involves the development of modeling and analysis design tools for assessing offshore wind turbine technologies. The computational tools developed herein are able to resolve the effects of the coupled interaction of atmospheric turbulence and ocean waves on aerodynamic performance and structural stability and reliability of offshore wind turbines and farms. Laboratory scale experiments have been carried out to derive data sets for validating the computational models.

  18. Advanced validation of CFD-FDTD combined method using highly applicable solver for reentry blackout prediction

    OpenAIRE

    Takahashi, Yusuke

    2015-01-01

    An analysis model of plasma flow and electromagnetic waves around a reentry vehicle for radio frequency blackout prediction during aerodynamic heating was developed in this study. The model was validated based on experimental results from the radio attenuation measurement program. The plasma flow properties, such as electron number density, in the shock layer and wake region were obtained using a newly developed unstructured grid solver that incorporated real gas effect models ...

  19. Convergence analysis of combinations of different methods

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Y. [Clarkson Univ., Potsdam, NY (United States)

    1994-12-31

    This paper provides a convergence analysis for combinations of different numerical methods for solving systems of differential equations. The author proves that combinations of two convergent linear multistep methods or Runge-Kutta methods produce a new convergent method of which the order is equal to the smaller order of the two original methods.

  20. TAUBERIAN THEOREMS FOR WEAK ALMOST CONVERGENT FUNCTIONS

    Institute of Scientific and Technical Information of China (English)

    Meng-Kuang Kuo

    2011-01-01

    The almost convergent function which was introduced by Raimi [6] and dis- cussed by Ho [4], Das and Nanda [2, 3], is the continuous analogue of almost convergent sequences (see [5]). In this paper, we establish the Tauberian conditions and the Cauchy criteria for weak almost convergent functions on R2+.

  1. Validation of the Internet Addiction Test in Students at a Pakistani Medical and Dental School.

    Science.gov (United States)

    Waqas, Ahmed; Farooq, Faisal; Raza, Mohsin; Javed, Saamia Tahir; Khan, Spogmai; Ghumman, Mahrukh Elahi; Naveed, Sadiq; Haddad, Mark

    2017-08-17

    Despite growing concerns over pathological internet usage, studies based on validated psychometric instruments are still lacking in Pakistan. This study aimed to examine the psychometric properties of the Internet Addiction Test (IAT) in a sample of Pakistani students. A total of 522 students of medicine and dentistry completed the questionnaire, which consisted of four sections: (a) demographics, (b) number of hours spent on the Internet per day, (c) English version of the IAT, and (d) the Defense Style Questionnaire-40. Maximum likelihood analysis and principal axis factoring were used to validate the factor structure of the IAT. Convergent and criterion validity were assessed by correlating IAT scores with number of hours spent online and defense styles. Exploratory and confirmatory factor analysis reflected the goodness of fit of a unidimensional structure of the IAT, with a high alpha coefficient. The IAT had good face and convergent validity and no floor and ceiling effects, and was judged easy to read by participants.

  2. A MATHEMATICAL THEORY FOR LES CONVERGENCE

    Institute of Scientific and Technical Information of China (English)

    H. Lim; B. Plohr; T. Kaman; Y. Yu; V. Mahadeo; Y. Xu; H. Zhang; J. Glimm; S. Dutta; D. H. Sharp

    2012-01-01

    Practical simulations of turbulent processes are generally cutoff,with a grid resolution that stops within the inertial range,meaning that multiple active regions and length scales occur below the grid level and are not resolved.This is the regime of large eddy simulations (LES),in which the larger but not the smaller of the turbulent length scales are resolved.Solutions of the fluid Navier-Stokes equations,when considered in the inertial regime,are conventionally regarded as solutions of the Euler equations.In other words,the viscous and diffusive transport terms in the Navier-Stokes equations can be neglected in the inertial regime and in LES simulations,while the Euler equation becomes fundamental.For such simulations,significant new solution details emerge as the grid is refined. It follows that conventional notions of grid convergence are at risk of failure,and that a new,and weaker notion of convergence may be appropriate.It is generally understood that the LES or inertial regime is inherently fluctuating and its description must be statistical in nature.Here we develop such a point of view systematically,based on Young measures,which are measures depending on or indexed by space time points.In the Young measure dv(ξ)x,t,the random variable ξ of the measure is a solution state variable,i.e.,a solution dependent variable,representing momentum,density,energy and species concentrations,while the space time coordinates,x,t,serve to index the measure.Theoretical evidence suggests that convergence via Young measures is sufficiently weak to encompass the LES/inertial regime; numerical and theoretical evidence suggests that this notion may be required for passive scalar concentration and thermal degrees of freedom.Our objective in this research is twofold:turbulent simulations without recourse to adjustable parameters (calibration) and extension to more complex physics,without use of additional models or parameters,in both cases with validation through comparison

  3. High Performance Computing Application: Solar Dynamo Model Project II, Corona and Heliosphere Component Initialization, Integration and Validation

    Science.gov (United States)

    2015-06-24

    allocate solar heating into any location of the corona . Its total contribution depended on the integration of the unsigned magnetic flux at 1 Rs...AFRL-RD-PS- TR-2015-0028 AFRL-RD-PS- TR-2015-0028 HIGH PERFORMANCE COMPUTING APPLICATION: SOLAR DYNAMO MODEL PROJECT II; CORONA AND HELIOSPHERE...Dynamo Model Project II, Corona and Heliosphere Component Initialization, Integration and Validation 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  4. The Origin of Weak Lensing Convergence Peaks

    CERN Document Server

    Liu, Jia

    2016-01-01

    Weak lensing convergence peaks are a promising tool to probe nonlinear structure evolution at late times, providing additional cosmological information beyond second-order statistics. Previous theoretical and observational studies have shown that the cosmological constraints on $\\Omega_m$ and $\\sigma_8$ are improved by a factor of up to ~ 2 when peak counts and second-order statistics are combined, compared to using the latter alone. We study the origin of lensing peaks using observational data from the 154 deg$^2$ Canada-France-Hawaii Telescope Lensing Survey. We found that while high peaks (with height $\\kappa$ >3.5 $\\sigma_\\kappa$, where $\\sigma_\\kappa$ is the r.m.s. of the convergence $\\kappa$) are typically due to one single massive halo of ~$10^{15}M_\\odot$, low peaks ($\\kappa$ ~ their virial radii), compared with ~0.25 virial radii for halos linked with high peaks, hinting that low peaks are more immune to baryonic processes whose impact is confined to the inner regions of the dark matter halos. Our fi...

  5. Convergences in the diversification of bats

    Directory of Open Access Journals (Sweden)

    M. Brock FENTON

    2010-08-01

    Full Text Available Twenty-five characters or suites of characters from bats are considered in light of changes in bat classification. The characters include some associated with flower-visiting (two, echolocation (12, roosting (six, reproduction (two and three are of unknown adaptive function. In both the 1998 and 2006 classifications of bats into suborders (Megachiroptera and Microchiroptera versus Yinpterochiroptera and Yangochiroptera, respectively, some convergences between suborders are the same (e.g., foliage roosting, tent building, but others associated with echolocation differ substantially. In the 1998 phylogeny convergences associated with echolocation (high duty cycle echolocation, nasal emission of echolocation calls occurred among the Microchiroptera. In the 2006 phylogeny, they occur between Yinpterochiroptera and Yangochiroptera. While some traits apparently arose independently in two suborders (e.g., foliage-roosting, tent building, low intensity echolocation calls, noseleafs, nasal emission of echolocation calls, high duty cycle echolocation behaviour, others appear to have been ancestral (roosting in narrow spaces, laryngeal echolocation, stylohyal-tympanic contact, oral emission of echolocation calls, and small litter size. A narrow profile through the chest is typical of bats reflecting the thoracic skeleton. This feature suggests that the ancestors of bats spent the day in small crevices. Features associated with laryngeal echolocation appear to be ancestral, suggesting that echolocation evolved early in bats but was subsequently lost in one yinpterochiropteran lineage [Current Zoology 56 (4: 454–468, 2010].

  6. Conformer generation with OMEGA: algorithm and validation using high quality structures from the Protein Databank and Cambridge Structural Database.

    Science.gov (United States)

    Hawkins, Paul C D; Skillman, A Geoffrey; Warren, Gregory L; Ellingson, Benjamin A; Stahl, Matthew T

    2010-04-26

    Here, we present the algorithm and validation for OMEGA, a systematic, knowledge-based conformer generator. The algorithm consists of three phases: assembly of an initial 3D structure from a library of fragments; exhaustive enumeration of all rotatable torsions using values drawn from a knowledge-based list of angles, thereby generating a large set of conformations; and sampling of this set by geometric and energy criteria. Validation of conformer generators like OMEGA has often been undertaken by comparing computed conformer sets to experimental molecular conformations from crystallography, usually from the Protein Databank (PDB). Such an approach is fraught with difficulty due to the systematic problems with small molecule structures in the PDB. Methods are presented to identify a diverse set of small molecule structures from cocomplexes in the PDB that has maximal reliability. A challenging set of 197 high quality, carefully selected ligand structures from well-solved models was obtained using these methods. This set will provide a sound basis for comparison and validation of conformer generators in the future. Validation results from this set are compared to the results using structures of a set of druglike molecules extracted from the Cambridge Structural Database (CSD). OMEGA is found to perform very well in reproducing the crystallographic conformations from both these data sets using two complementary metrics of success.

  7. A Global Lake Ecological Observatory Network (GLEON) for synthesising high-frequency sensor data for validation of deterministic ecological models

    Science.gov (United States)

    David, Hamilton P; Carey, Cayelan C.; Arvola, Lauri; Arzberger, Peter; Brewer, Carol A.; Cole, Jon J; Gaiser, Evelyn; Hanson, Paul C.; Ibelings, Bas W; Jennings, Eleanor; Kratz, Tim K; Lin, Fang-Pang; McBride, Christopher G.; de Motta Marques, David; Muraoka, Kohji; Nishri, Ami; Qin, Boqiang; Read, Jordan S.; Rose, Kevin C.; Ryder, Elizabeth; Weathers, Kathleen C.; Zhu, Guangwei; Trolle, Dennis; Brookes, Justin D

    2014-01-01

    A Global Lake Ecological Observatory Network (GLEON; www.gleon.org) has formed to provide a coordinated response to the need for scientific understanding of lake processes, utilising technological advances available from autonomous sensors. The organisation embraces a grassroots approach to engage researchers from varying disciplines, sites spanning geographic and ecological gradients, and novel sensor and cyberinfrastructure to synthesise high-frequency lake data at scales ranging from local to global. The high-frequency data provide a platform to rigorously validate process- based ecological models because model simulation time steps are better aligned with sensor measurements than with lower-frequency, manual samples. Two case studies from Trout Bog, Wisconsin, USA, and Lake Rotoehu, North Island, New Zealand, are presented to demonstrate that in the past, ecological model outputs (e.g., temperature, chlorophyll) have been relatively poorly validated based on a limited number of directly comparable measurements, both in time and space. The case studies demonstrate some of the difficulties of mapping sensor measurements directly to model state variable outputs as well as the opportunities to use deviations between sensor measurements and model simulations to better inform process understanding. Well-validated ecological models provide a mechanism to extrapolate high-frequency sensor data in space and time, thereby potentially creating a fully 3-dimensional simulation of key variables of interest.

  8. Ecomorphological convergence in planktivorous surgeonfishes

    KAUST Repository

    Friedman, S. T.

    2016-01-26

    © 2016 European Society For Evolutionary Biology. Morphological convergence plays a central role in the study of evolution. Often induced by shared ecological specialization, homoplasy hints at underlying selective pressures and adaptive constraints that deterministically shape the diversification of life. Although midwater zooplanktivory has arisen in adult surgeonfishes (family Acanthuridae) at least four independent times, it represents a clearly specialized state, requiring the capacity to swiftly swim in midwater locating and sucking small prey items. Whereas this diet has commonly been associated with specific functional adaptations in fishes, acanthurids present an interesting case study as all nonplanktivorous species feed by grazing on benthic algae and detritus, requiring a vastly different functional morphology that emphasizes biting behaviours. We examined the feeding morphology in 30 acanthurid species and, combined with a pre-existing phylogenetic tree, compared the fit of evolutionary models across two diet regimes: zooplanktivores and nonzooplanktivorous grazers. Accounting for phylogenetic relationships, the best-fitting model indicates that zooplanktivorous species are converging on a separate adaptive peak from their grazing relatives. Driving this bimodal landscape, zooplanktivorous acanthurids tend to develop a slender body, reduced facial features, smaller teeth and weakened jaw adductor muscles. However, despite these phenotypic changes, model fitting suggests that lineages have not yet reached the adaptive peak associated with plankton feeding even though some transitions appear to be over 10 million years old. These findings demonstrate that the selective demands of pelagic feeding promote repeated - albeit very gradual - ecomorphological convergence within surgeonfishes, while allowing local divergences between closely related species, contributing to the overall diversity of the clade. Journal of Evolutionary Biology

  9. Weak* convergence of operator means

    Energy Technology Data Exchange (ETDEWEB)

    Romanov, Alexandr V [Moscow State Institute of Electronics and Mathematics (Technical University), Moscow (Russian Federation)

    2011-12-31

    For a linear operator U with ||U'n||{<=}const on a Banach space X we discuss conditions for the convergence of ergodic operator nets T{sub {alpha}} corresponding to the adjoint operator U* of U in the W*O-topology of the space EndX*. The accumulation points of all possible nets of this kind form a compact convex set L in EndX*, which is the kernel of the operator, where {Gamma}{sub 0}={l_brace}U{sub n}*, n{>=}0{r_brace}. It is proved that all ergodic nets T{sub {alpha}} weakly* converge if and only if the kernel L consists of a single element. In the case of X=C({Omega}) and the shift operator U generated by a continuous transformation {phi} of a metrizable compactum {Omega} we trace the relationships among the ergodic properties of U, the structure of the operator semigroups L, G and {Gamma}={Gamma}-bar{sub 0}, and the dynamical characteristics of the semi-cascade ({phi},{Omega}). In particular, if cardL=1, then a) for any {omega} element of {Omega} the closure of the trajectory {l_brace}{phi}{sup n}{omega}, n{>=}0{r_brace} contains precisely one minimal set m, and b) the restriction ({phi},m) is strictly ergodic. Condition a) implies the W*O-convergence of any ergodic sequence of operators T{sub n} element of EndX* under the additional assumption that the kernel of the enveloping semigroup E({phi},{Omega}) contains elements obtained from the 'basis' family of transformations {l_brace}{phi}{sup n}, n{>=}0{r_brace} of the compact set {Omega} by using some transfinite sequence of sequential passages to the limit.

  10. Exploring the Image Types of Secondary School Students' Perception about the Talented Person in Convergence

    Science.gov (United States)

    Lee, Jun-Ki; Chung, Duk Ho

    2014-05-01

    This study aims to identify the image types of secondary school students' perception about the talented person in convergence and to find the differences in drawing images of the talented person in convergence among the students who have taken STEAM class and the ones who haven't. One hundred and eighty seven students in middle and high schools located in the southern part of South Korea participated in this study and they were asked to draw a picture of the talented person in convergence with a brief explanation. Based on students' pictures, researchers categorized their perception about convergence and talented person in convergence by using an inductive method. The result indicated that secondary school students' perceptions were categorized into convergence as individual cognitive processing and collective cognitive processing and convergence as outcomes. The image of the convergence in a talented person leaning toward individual cognitive processing was divided into the following seven types: idea banker type, various talented celebrity type, multi-tasking master type, multi-talented career type, active problem-solver type, creative developer type, and unrealistic ideal man type. Another image of collective cognitive processing was split into expert group type and interactive-mates group type. The other image was transformer type which is the subcategory of convergence as outcomes. From this study, it can be suggested that secondary school students express the various images of the talented person in convergence depending on experiencing STEAM or not. Keywords: talented person in convergence, secondary school students, STEAM, image types

  11. SCORE DIGITAL TECHNOLOGY: THE CONVERGENCE

    Directory of Open Access Journals (Sweden)

    Chernyshov Alexander V.

    2013-12-01

    Full Text Available Explores the role of digital scorewriters in today's culture, education, and music industry and media environment. The main principle of the development of software is not only publishing innovation (relating to the sheet music, and integration into the area of composition, arrangement, education, creative process for works based on digital technology (films, television and radio broadcasting, Internet, audio and video art. Therefore the own convergence of musically-computer technology is a total phenomenon: notation program combined with means MIDI-sequencer, audio and video editor. The article contains the unique interview with the creator of music notation processors.

  12. Validation of the Child Sport Cohesion Questionnaire

    Science.gov (United States)

    Martin, Luc J.; Carron, Albert V.; Eys, Mark A.; Loughead, Todd

    2013-01-01

    The purpose of the present study was to test the validity evidence of the Child Sport Cohesion Questionnaire (CSCQ). To accomplish this task, convergent, discriminant, and known-group difference validity were examined, along with factorial validity via confirmatory factor analysis (CFA). Child athletes (N = 290, M[subscript age] = 10.73 plus or…

  13. Validation of the Child Sport Cohesion Questionnaire

    Science.gov (United States)

    Martin, Luc J.; Carron, Albert V.; Eys, Mark A.; Loughead, Todd

    2013-01-01

    The purpose of the present study was to test the validity evidence of the Child Sport Cohesion Questionnaire (CSCQ). To accomplish this task, convergent, discriminant, and known-group difference validity were examined, along with factorial validity via confirmatory factor analysis (CFA). Child athletes (N = 290, M[subscript age] = 10.73 plus or…

  14. Determination of total sulfur in fertilizers by high temperature combustion: single-laboratory validation.

    Science.gov (United States)

    Bernius, Jean; Kraus, Sabine; Hughes, Sandra; Margraf, Dominik; Bartos, James; Newlon, Natalie; Sieper, Hans-Peter

    2014-01-01

    Asingle-laboratory validation study was conducted for the determination of total sulfur (S) in a variety of common, inorganic fertilizers by combustion. The procedure involves conversion of S species into SO2 through combustion at 1150 degrees C, absorption then desorption from a purge and trap column, followed by measurement by a thermal conductivity detector. Eleven different validation materials were selected for study, which included four commercial fertilizer products, five fertilizers from the Magruder Check Sample Program, one reagent grade product, and one certified organic reference material. S content ranged between 1.47 and 91% as sulfate, thiosulfate, and elemental and organically bound S. Determinations of check samples were performed on 3 different days with four replicates/day. Determinations for non-Magruder samples were performed on 2 different days. Recoveries ranged from 94.3 to 125.9%. ABS SL absolute SD among runs ranged from 0.038 to 0.487%. Based on the accuracy and precision demonstrated here, it is recommended that this method be collaboratively studied for the determination of total S in fertilizers.

  15. CFD Model Development and validation for High Temperature Gas Cooled Reactor Cavity Cooling System (RCCS) Applications

    Energy Technology Data Exchange (ETDEWEB)

    Hassan, Yassin [Univ. of Wisconsin, Madison, WI (United Texas A & M Univ., College Station, TX (United States); Corradini, Michael; Tokuhiro, Akira; Wei, Thomas Y.C.

    2014-07-14

    The Reactor Cavity Cooling Systems (RCCS) is a passive safety system that will be incorporated in the VTHR design. The system was designed to remove the heat from the reactor cavity and maintain the temperature of structures and concrete walls under desired limits during normal operation (steady-state) and accident scenarios. A small scale (1:23) water-cooled experimental facility was scaled, designed, and constructed in order to study the complex thermohydraulic phenomena taking place in the RCCS during steady-state and transient conditions. The facility represents a portion of the reactor vessel with nine stainless steel coolant risers and utilizes water as coolant. The facility was equipped with instrumentation to measure temperatures and flow rates and a general verification was completed during the shakedown. A model of the experimental facility was prepared using RELAP5-3D and simulations were performed to validate the scaling procedure. The experimental data produced during the steady-state run were compared with the simulation results obtained using RELAP5-3D. The overall behavior of the facility met the expectations. The facility capabilities were confirmed to be very promising in performing additional experimental tests, including flow visualization, and produce data for code validation.

  16. Pointwise convergence of Fourier series

    CERN Document Server

    Arias de Reyna, Juan

    2002-01-01

    This book contains a detailed exposition of Carleson-Hunt theorem following the proof of Carleson: to this day this is the only one giving better bounds. It points out the motivation of every step in the proof. Thus the Carleson-Hunt theorem becomes accessible to any analyst.The book also contains the first detailed exposition of the fine results of Hunt, Sjölin, Soria, etc on the convergence of Fourier Series. Its final chapters present original material. With both Fefferman's proof and the recent one of Lacey and Thiele in print, it becomes more important than ever to understand and compare these two related proofs with that of Carleson and Hunt. These alternative proofs do not yield all the results of the Carleson-Hunt proof. The intention of this monograph is to make Carleson's proof accessible to a wider audience, and to explain its consequences for the pointwise convergence of Fourier series for functions in spaces near $äcal Lü^1$, filling a well-known gap in the literature.

  17. Model validation and error estimation of tsunami runup using high resolution data in Sadeng Port, Gunungkidul, Yogyakarta

    Science.gov (United States)

    Basith, Abdul; Prakoso, Yudhono; Kongko, Widjo

    2017-07-01

    A tsunami model using high resolution geometric data is indispensable in efforts to tsunami mitigation, especially in tsunami prone areas. It is one of the factors that affect the accuracy results of numerical modeling of tsunami. Sadeng Port is a new infrastructure in the Southern Coast of Java which could potentially hit by massive tsunami from seismic gap. This paper discusses validation and error estimation of tsunami model created using high resolution geometric data in Sadeng Port. Tsunami model validation uses the height wave of Tsunami Pangandaran 2006 recorded by Tide Gauge of Sadeng. Tsunami model will be used to accommodate the tsunami numerical modeling involves the parameters of earthquake-tsunami which is derived from the seismic gap. The validation results using t-test (student) shows that the height of the tsunami modeling results and observation in Tide Gauge of Sadeng are considered statistically equal at 95% confidence level and the value of the RMSE and NRMSE are 0.428 m and 22.12%, while the differences of tsunami wave travel time is 12 minutes.

  18. Development of Safety Analysis Codes and Experimental Validation for a Very High Temperature Gas-Cooled Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chang, H. Oh, PhD; Cliff Davis; Richard Moore

    2004-11-01

    The very high temperature gas-cooled reactors (VHTGRs) are those concepts that have average coolant temperatures above 900 degrees C or operational fuel temperatures above 1250 degrees C. These concepts provide the potential for increased energy conversion efficiency and for high-temperature process heat application in addition to power generation and nuclear hydrogen generation. While all the High Temperature Gas Cooled Reactor (HTGR) concepts have sufficiently high temperatures to support process heat applications, such as desalination and cogeneration, the VHTGR's higher temperatures are suitable for particular applications such as thermochemical hydrogen production. However, the high temperature operation can be detrimental to safety following a loss-of-coolant accident (LOCA) initiated by pipe breaks caused by seismic or other events. Following the loss of coolant through the break and coolant depressurization, air from the containment will enter the core by molecular diffusion and ultimately by natural convection, leading to oxidation of the in-core graphite structures and fuel. The oxidation will release heat and accelerate the heatup of the reactor core. Thus, without any effective countermeasures, a pipe break may lead to significant fuel damage and fission product release. The Idaho National Engineering and Environmental Laboratory (INEEL) has investigated this event for the past three years for the HTGR. However, the computer codes used, and in fact none of the world's computer codes, have been sufficiently developed and validated to reliably predict this event. New code development, improvement of the existing codes, and experimental validation are imperative to narrow the uncertaninty in the predictions of this type of accident. The objectives of this Korean/United States collaboration are to develop advanced computational methods for VHTGR safety analysis codes and to validate these computer codes.

  19. Development of safety analysis codes and experimental validation for a very high temperature gas-cooled reactor Final report

    Energy Technology Data Exchange (ETDEWEB)

    Chang Oh

    2006-03-01

    The very high-temperature gas-cooled reactor (VHTR) is envisioned as a single- or dual-purpose reactor for electricity and hydrogen generation. The concept has average coolant temperatures above 9000C and operational fuel temperatures above 12500C. The concept provides the potential for increased energy conversion efficiency and for high-temperature process heat application in addition to power generation. While all the High Temperature Gas Cooled Reactor (HTGR) concepts have sufficiently high temperature to support process heat applications, such as coal gasification, desalination or cogenerative processes, the VHTR’s higher temperatures allow broader applications, including thermochemical hydrogen production. However, the very high temperatures of this reactor concept can be detrimental to safety if a loss-of-coolant accident (LOCA) occurs. Following the loss of coolant through the break and coolant depressurization, air will enter the core through the break by molecular diffusion and ultimately by natural convection, leading to oxidation of the in-core graphite structure and fuel. The oxidation will accelerate heatup of the reactor core and the release of toxic gasses (CO and CO2) and fission products. Thus, without any effective countermeasures, a pipe break may lead to significant fuel damage and fission product release. Prior to the start of this Korean/United States collaboration, no computer codes were available that had been sufficiently developed and validated to reliably simulate a LOCA in the VHTR. Therefore, we have worked for the past three years on developing and validating advanced computational methods for simulating LOCAs in a VHTR. Research Objectives As described above, a pipe break may lead to significant fuel damage and fission product release in the VHTR. The objectives of this Korean/United States collaboration were to develop and validate advanced computational methods for VHTR safety analysis. The methods that have been developed are now

  20. Preliminary validation of high performance liquid chromatography method for detection of methyl-testosterone residue in carp muscle

    Science.gov (United States)

    Jiang, Jie; Lin, Hong; Fu, Xiaoting; Li, Mingming

    2005-07-01

    The use of synthetic anabolic steroid methyltestosterone (MT) as growth promoter is prohibited in China. Validations of analytical methods for MT residue in food and the results obtained have become indispensable. The high performance liquid chromatography (HPLC) method for the detection of MT with liquid-liquid extraction by trichloromethane-methanol in carp muscle tissue was preliminarily validated with reference to the following parameters: recovery (accuracy) at the 1, 5 and l0 mgkg-1 level, between-run and within-run CV values (repeatability, also called relative standard deviation (RSD)) and limit of detection. The recoveries were above 80% and the between-run and within-run CV values below 10% for muscle tissue. The limit of detection was 0.05 mgkg-1.

  1. Development and validation of a rapid ultra high pressure liquid chromatographic method for the determination of methylxanthines in herbal infusions.

    Science.gov (United States)

    Zacharis, Constantinos K; Kika, Fotini S; Tzanavaras, Paraskevas D; Fytianos, Konstantinos

    2013-05-15

    An ultra high pressure liquid chromatographic method coupled with diode array detector (UHPLC-DAD) has been developed and validated for the fast separation and determination of three major methylxanthines, i.e., caffeine, theophylline and theobromine, in various herbal beverages. Isocratic elution using 0.1vol% formic acid/CH3OH (92.5:7.5, v/v) enabled the completion of the separation cycle in less than 3min using a flow rate of 0.7mL/min and a column temperature of 50°C. Validation of the method included linearity (0.5-50mg/L), limits of detection (12-35μg/L) and quantification (40-120μg/L), precision, matrix effect and accuracy. The percent recoveries ranged between 90 and 108%.

  2. Development and validation of a high performance liquid chromatography method for oligodeoxynucleotides determination in a novel coagel-based formulation

    Directory of Open Access Journals (Sweden)

    Gabriela V. Ullio-Gamboa

    2015-06-01

    However, due to inter-assay variability and accuracy problems associated with the afore mentioned methods, we have developed and validated an isocratic high performance liquid chromatographic (HPLC for analytical determination of PS-ODN containing unmethylated CpG motifs (CpG-ODN. Validation under Food and Drug Administration (FDA guidelines of the analytical parameters include: linearity (r2 0.9996, LOD (0.86 μg/ml and LOQ (6.25 μg/ml, intra (0.19–3.37% and inter-day precision (0.63–3.75% expressed as relative standard deviation (RSD, and robustness parameters (less than 2.80%. Using this method, recoveries ranging from 89.9% to 99.9% were obtained. Thus, this method provides a simple, sensitive, precise and reproducible examination which can be readily adapted for the assessment of CpG-ODN in different pharmaceutical preparations.

  3. Development and Validation of High Performance Liquid Chromatographic Method for Determination of Lamivudine from Pharmaceutical Preparation

    Directory of Open Access Journals (Sweden)

    S. K. Patro

    2010-01-01

    Full Text Available A new, simple, specific, accurate and precise RP-HPLC method was developed for determination of lamivudine in pure and tablet formulations. A Thermo BDS C18 column in isocratic mode, with a mobile phase consisting of 0.01 M ammonium dihydrogen orthophosphate buffer adjusted to pH 2.48 by using formic acid and methanol in the ratio of 50:50 was used. The flow rate was set at 0.6 mL/min and UV detection was carried out at 264 nm. The retention time of lamivudine and nevirapine were 2.825 min and 4.958 min respectively. The method was validated for linearity, precision, robustness and recovery. Linearity for lamivudine was found in the range of 50-175 μg/mL. Hence, it can be applied for routine quality control of lamivudine in bulk and pharmaceutical formulations.

  4. Validating a Model for Welding Induced Residual Stress Using High-Energy X-ray Diffraction

    Science.gov (United States)

    Mach, J. C.; Budrow, C. J.; Pagan, D. C.; Ruff, J. P. C.; Park, J.-S.; Okasinski, J.; Beaudoin, A. J.; Miller, M. P.

    2017-03-01

    Integrated computational materials engineering (ICME) provides a pathway to advance performance in structures through the use of physically-based models to better understand how manufacturing processes influence product performance. As one particular challenge, consider that residual stresses induced in fabrication are pervasive and directly impact the life of structures. For ICME to be an effective strategy, it is essential that predictive capability be developed in conjunction with critical experiments. In the present work, simulation results from a multi-physics model for gas metal arc welding are evaluated through x-ray diffraction using synchrotron radiation. A test component was designed with intent to develop significant gradients in residual stress, be representative of real-world engineering application, yet remain tractable for finely spaced strain measurements with positioning equipment available at synchrotron facilities. The experimental validation lends confidence to model predictions, facilitating the explicit consideration of residual stress distribution in prediction of fatigue life.

  5. Validation of the solar heating and cooling high speed performance (HISPER) computer code

    Science.gov (United States)

    Wallace, D. B.

    1980-10-01

    Developed to give a quick and accurate predictions HISPER, a simplification of the TRNSYS program, achieves its computational speed by not simulating detailed system operations or performing detailed load computations. In order to validate the HISPER computer for air systems the simulation was compared to the actual performance of an operational test site. Solar insolation, ambient temperature, water usage rate, and water main temperatures from the data tapes for an office building in Huntsville, Alabama were used as input. The HISPER program was found to predict the heating loads and solar fraction of the loads with errors of less than ten percent. Good correlation was found on both a seasonal basis and a monthly basis. Several parameters (such as infiltration rate and the outside ambient temperature above which heating is not required) were found to require careful selection for accurate simulation.

  6. Validation of High-Resolution CFD Method for Slosh Damping Extraction of Baffled Cryogenic Propellant Tanks

    Science.gov (United States)

    Yang, H. Q.; West, Jeff

    2016-01-01

    Propellant slosh is a potential source of disturbance critical to the stability of space vehicles. The slosh dynamics are typically represented by a mechanical model of a spring-mass-damper. This mechanical model is then included in the equation of motion of the entire vehicle for Guidance, Navigation and Control analysis. A Volume-Of-Fluid (VOF) based Computational Fluid Dynamics (CFD) program developed at MSFC was applied to extract slosh damping in the baffled tank from the first principle. First the experimental data using water with sub-scale smooth wall tank were used as the baseline validation. It is demonstrated that CFD can indeed accurately predict low damping values from the smooth wall at different fill levels. The damping due to a ring baffles at different depths from the free surface was then simulated, and fairly good agreement with experimental measurement was observed. Comparison with an empirical correlation of Miles equation is also made.

  7. a Study on Producing Highly Reliabile Reference Data Sets for Global Land Cover Validation

    Science.gov (United States)

    Soyama, N.; Muramatsu, K.; Daigo, M.; Ochiai, F.; Fujiwara, N.

    2016-06-01

    Validating the accuracy of land cover products using a reliable reference dataset is an important task. A reliable reference dataset is produced with information derived from ground truth data. Recently, the amount of ground truth data derived from information collected by volunteers has been increasing globally. The acquisition of volunteer-based reference data demonstrates great potential. However information given by volunteers is limited useful vegetation information to produce a complete reference dataset based on the plant functional type (PFT) with five specialized forest classes. In this study, we examined the availability and applicability of FLUXNET information to produce reference data with higher levels of reliability. FLUXNET information was useful especially for forest classes for interpretation in comparison with the reference dataset using information given by volunteers.

  8. Validating a Model for Welding Induced Residual Stress Using High-Energy X-ray Diffraction

    Science.gov (United States)

    Mach, J. C.; Budrow, C. J.; Pagan, D. C.; Ruff, J. P. C.; Park, J.-S.; Okasinski, J.; Beaudoin, A. J.; Miller, M. P.

    2017-05-01

    Integrated computational materials engineering (ICME) provides a pathway to advance performance in structures through the use of physically-based models to better understand how manufacturing processes influence product performance. As one particular challenge, consider that residual stresses induced in fabrication are pervasive and directly impact the life of structures. For ICME to be an effective strategy, it is essential that predictive capability be developed in conjunction with critical experiments. In the present work, simulation results from a multi-physics model for gas metal arc welding are evaluated through x-ray diffraction using synchrotron radiation. A test component was designed with intent to develop significant gradients in residual stress, be representative of real-world engineering application, yet remain tractable for finely spaced strain measurements with positioning equipment available at synchrotron facilities. The experimental validation lends confidence to model predictions, facilitating the explicit consideration of residual stress distribution in prediction of fatigue life.

  9. High-resolution wave model validation over the Greek maritime areas

    Directory of Open Access Journals (Sweden)

    N. Mazarakis

    2012-11-01

    Full Text Available The increasing maritime activity can be seriously affected by severe weather and sea conditions. To avoid serious damages to ships, marine structures and humans, a good weather and wave forecast is of primary importance. In general the meteorological and the wave models are used to produce forecasts at large scale like the global or the medium-size inner seas. For much smaller environments like the Greek maritime areas, characterized by complicated features like the orography and the presence of islands, the modelisation becomes a not simple task.

    This study is devoted to the validation of the performance of the WAM wave model over the Ionian and Aegean Seas. The period of validation refers to the first 12 months of operational use of the model at the National Observatory of Athens. The wave model is applied at a resolution of 1/16 degrees and is driven by the 10 m wind, produced by the BOLAM meteorological model operationally run over the same area. Two different sources of data have been used for the verification of the model results. The first dataset is provided by a network of buoys deployed over the Greek maritime areas and the second consists of altimeter data, provided by the OSTM/Jason-2 satellite platform. Although the study area is characterized by complex topography and a large number of islands, the implementation of the WAM model provides very encouraging results. In general, with the exception of the two buoys located in the Ionian Sea, the WAM model tends to underestimate the wave energy in the region of the Aegean Sea. The comparison with the altimeter data shows that the model has a tendency to overestimate the height for waves lower than 2.5 m and to underestimate the waves higher than 3 m.

  10. Validation of High-Resolution CFD Method for Slosh Damping Extraction of Baffled Tanks

    Science.gov (United States)

    Yang, H. Q.; West, Jeff

    2016-01-01

    Determination of slosh damping is a very challenging task as there is no analytical solution. The damping physics involve the vorticity dissipation which requires the full solution of the nonlinear Navier-Stokes equations. As a result, previous investigations and knowledge were mainly carried out by extensive experimental studies. A Volume-Of-Fluid (VOF) based CFD program developed at NASA MSFC was applied to extract slosh damping in a baffled tank from the first principle. First, experimental data using water with subscale smooth wall tank were used as the baseline validation. CFD simulation was demonstrated to be capable of accurately predicting natural frequency and very low damping value from the smooth wall tank at different fill levels. The damping due to a ring baffle at different liquid fill levels from barrel section and into the upper dome was then investigated to understand the slosh damping physics due to the presence of a ring baffle. Based on this study, the Root-Mean-Square error of our CFD simulation in estimating slosh damping was less than 4.8%, and the maximum error was less than 8.5%. Scalability of subscale baffled tank test using water was investigated using the validated CFD tool, and it was found that unlike the smooth wall case, slosh damping with baffle is almost independent of the working fluid and it is reasonable to apply water test data to the full scale LOX tank when the damping from baffle is dominant. On the other hand, for the smooth wall, the damping value must be scaled according to the Reynolds number. Comparison of experimental data, CFD, with the classical and modified Miles equations for upper dome was made, and the limitations of these semi-empirical equations were identified.

  11. Convergencia oblicua: modelo estructural alternativo para la dorsal Neuquina (39ºs - Neuquén Oblique convergence: alternative structural model for the Neuquén high (39º S, Neuquén

    Directory of Open Access Journals (Sweden)

    José Silvestro

    2008-03-01

    structural lineament recognized as Neuquen high developed at 39º S latitude, is extended for more than 270 km in an E-W direction, defining the natural northern boundary of the Argentine Patagonia. The tectonic activity in this zone during Jurassic and Cretaceous times controlled the sedimentation of the basin, given place to a series of growth sequences and related unconformities. The structural features allows the recognition of a western sector where NE trending anticlines predominate related to high angle reverse basement faults and an eastern sector where the lineaments are NW trending and developed right-lateral wrench structures. The particular orientation of the Neuquen high, almost orthogonal to the Andean belt, and its complex structural features, were traditionally explained by two end-member models: wrench and inversion tectonics. Based on new subsurface data and the development of new structural concepts, an alternative model is proposed combining wrench-dominated tectonics trends with oblique inversion of half-grabens and basement related tectonics without influence of previous extensional features. The plan-view distribution of the structures and its evolution through time is explained by oblique convergence between a rigid block located to the southeast (Northpatagonian Craton, acting as a backstop with its boundaries sub-parallel to Negro and Limay rivers; which converge with a zone to the north able to be folded represented by the Neuquen basin, under an NW-SE oriented stress field. This model explains the distribution and orientation of the compressive and wrench dominated zones and its structural evolution where younger structures are developed from the SE to the NW towards the outer part of the system.

  12. The Convergence Study of the Homotopy Analysis Method for Solving Nonlinear Volterra-Fredholm Integrodifferential Equations

    Directory of Open Access Journals (Sweden)

    Behzad Ghanbari

    2014-01-01

    Full Text Available We aim to study the convergence of the homotopy analysis method (HAM in short for solving special nonlinear Volterra-Fredholm integrodifferential equations. The sufficient condition for the convergence of the method is briefly addressed. Some illustrative examples are also presented to demonstrate the validity and applicability of the technique. Comparison of the obtained results HAM with exact solution shows that the method is reliable and capable of providing analytic treatment for solving such equations.

  13. [The esotropia of the convergence-excess type subdivided into two forms].

    Science.gov (United States)

    Niu, Lan-jun

    2008-11-01

    There are two types of convergence excess esotropia in the classification of strabismus in our country. One is nonrefractive accommodative esotropia and another is nonaccommodative convergence excess esotropia. Inadequate heterophoria method to determine the AC/A ratio does not distinguish between a high AC/A ratio and nonaccommodative convergence excess. The diagnosis of nonrefractive accommodative esotropia is based on the presence of a high AC/A ratio as established with the gradient method to distinguish this condition from nonaccommative convergence excess.

  14. Design and Validation of the GI-NEC Score to Prognosticate Overall Survival in Patients With High-Grade Gastrointestinal Neuroendocrine Carcinomas

    OpenAIRE

    Valle, Juan; Lamarca, Angela; McNamara, Mairead; Hubner, Richard; Barriuso, Jorge

    2017-01-01

    BACKGROUND: Prognostic markers for risk stratification of patients with gastrointestinal high-grade neuroendocrine carcinomas (GI-NECs) are lacking; we designed and validated a prognostic score for overall survival (OS). METHODS: Consecutive patients diagnosed in five neuroendocrine specialist European centers were included. Patients were divided into three cohorts: a training cohort (TC), an external validation cohort (EVC), and a prospective validation cohort (PVC). Prognostic factors were ...

  15. Determination of alpha-methyldopa in human plasma by validated high-performance liquid chromatography with fluorescence detection.

    Science.gov (United States)

    Róna, K; Ary, K; Gachályi, B; Klebovich, I

    1996-04-12

    A sensitive reversed-phase gradient elution high-performance liquid chromatographic method with fluorescence detection has been developed for the determination of alpha-methyldopa (AMD) in human plasma. Separation of the investigated compound and the 3,4-dihydroxyphenylalanine (DOPA) internal standard was achieved on a Nucleosil 7 C18 column with a 5 mM heptanesulphonic acid sodium salt containing 0.05 M potassium dihydrogenphosphate (pH 3.2)-acetonitrile mobile phase. The composition of the mobile phase was changed according to a linear gradient time program. Detection was performed at 270 nm fluorimetric excitation and 320 nm emission. The compounds were isolated from plasma by Bond-Elut C18 solid-phase extraction. The limit of quantitation was found to be 10 ng/ml plasma. The assay was validated with respect to accuracy, precision and system suitability. All validated parameters were found to be within the 20% required limits. On the basis of the sensitivity, linearity and validation parameters the developed analytical method was found to be suitable for application in a bioequivalency study.

  16. Validation of Suomi-NPP VIIRS sea ice concentration with very high-resolution satellite and airborne camera imagery

    Science.gov (United States)

    Baldwin, Daniel; Tschudi, Mark; Pacifici, Fabio; Liu, Yinghui

    2017-08-01

    Two independent VIIRS-based Sea Ice Concentration (SIC) products are validated against SIC as estimated from Very High Spatial Resolution Imagery for several VIIRS overpasses. The 375 m resolution VIIRS SIC from the Interface Data Processing Segment (IDPS) SIC algorithm is compared against estimates made from 2 m DigitalGlobe (DG) WorldView-2 imagery and also against estimates created from 10 cm Digital Mapping System (DMS) camera imagery. The 750 m VIIRS SIC from the Enterprise SIC algorithm is compared against DG imagery. The IDPS vs. DG comparisons reveal that, due to algorithm issues, many of the IDPS SIC retrievals were falsely assigned ice-free values when the pixel was clearly over ice. These false values increased the validation bias and RMS statistics. The IDPS vs. DMS comparisons were largely over ice-covered regions and did not demonstrate the false retrieval issue. The validation results show that products from both the IDPS and Enterprise algorithms were within or very close to the 10% accuracy (bias) specifications in both the non-melting and melting conditions, but only products from the Enterprise algorithm met the 25% specifications for the uncertainty (RMS).

  17. The expert nurse profile and diagnostic content validity of Sedentary Lifestyle: the Spanish validation.

    Science.gov (United States)

    Guirao-Goris, Josep Adolf; Duarte-Climents, Gonzalo

    2007-01-01

    To identify the diagnostic content validity of Sedentary Lifestyle and to identify the expert nurse profile in validating this nursing diagnosis in the Spanish cultural context. Fehring's Diagnostic Content Validity (DCV), the factorial validity of the defining characteristics, the analysis of convergent validity, and the expert profile were assessed. The DCV index for experts was .70. The factorial validity showed two different factors: the expression of laziness and the performance of activities of daily living. On the expert profile related factors analysis, two factors, experience and education, were identified. The DCV for Sedentary Lifestyle was high among the expert nurses. A nurse was considered to be an expert who was able to accurately answer the four labels identified as nursing diagnoses, had read at least one nursing process article in the past year, and was able to list three nursing process reference books. Clarifying the manifestations of sedentary lifestyle will assist clinical nurses in determining this diagnosis, and the expert profiles will assist in the selection of participants for content validity studies.

  18. Mosaic Convergence of Rodent Dentitions

    Science.gov (United States)

    Lazzari, Vincent; Charles, Cyril; Tafforeau, Paul; Vianey-Liaud, Monique; Aguilar, Jean-Pierre; Jaeger, Jean-Jacques; Michaux, Jacques; Viriot, Laurent

    2008-01-01

    Background Understanding mechanisms responsible for changes in tooth morphology in the course of evolution is an area of investigation common to both paleontology and developmental biology. Detailed analyses of molar tooth crown shape have shown frequent homoplasia in mammalian evolution, which requires accurate investigation of the evolutionary pathways provided by the fossil record. The necessity of preservation of an effective occlusion has been hypothesized to functionally constrain crown morphological changes and to also facilitate convergent evolution. The Muroidea superfamily constitutes a relevant model for the study of molar crown diversification because it encompasses one third of the extant mammalian biodiversity. Methodology/Principal Findings Combined microwear and 3D-topographic analyses performed on fossil and extant muroid molars allow for a first quantification of the relationships between changes in crown morphology and functionality of occlusion. Based on an abundant fossil record and on a well resolved phylogeny, our results show that the most derived functional condition associates longitudinal chewing and non interlocking of cusps. This condition has been reached at least 7 times within muroids via two main types of evolutionary pathways each respecting functional continuity. In the first type, the flattening of tooth crown which induces the removal of cusp interlocking occurs before the rotation of the chewing movement. In the second type however, flattening is subsequent to rotation of the chewing movement which can be associated with certain changes in cusp morphology. Conclusion/Significance The reverse orders of the changes involved in these different pathways reveal a mosaic evolution of mammalian dentition in which direction of chewing and crown shape seem to be partly decoupled. Either can change in respect to strong functional constraints affecting occlusion which thereby limit the number of the possible pathways. Because convergent

  19. Mosaic convergence of rodent dentitions.

    Directory of Open Access Journals (Sweden)

    Vincent Lazzari

    Full Text Available BACKGROUND: Understanding mechanisms responsible for changes in tooth morphology in the course of evolution is an area of investigation common to both paleontology and developmental biology. Detailed analyses of molar tooth crown shape have shown frequent homoplasia in mammalian evolution, which requires accurate investigation of the evolutionary pathways provided by the fossil record. The necessity of preservation of an effective occlusion has been hypothesized to functionally constrain crown morphological changes and to also facilitate convergent evolution. The Muroidea superfamily constitutes a relevant model for the study of molar crown diversification because it encompasses one third of the extant mammalian biodiversity. METHODOLOGY/PRINCIPAL FINDINGS: Combined microwear and 3D-topographic analyses performed on fossil and extant muroid molars allow for a first quantification of the relationships between changes in crown morphology and functionality of occlusion. Based on an abundant fossil record and on a well resolved phylogeny, our results show that the most derived functional condition associates longitudinal chewing and non interlocking of cusps. This condition has been reached at least 7 times within muroids via two main types of evolutionary pathways each respecting functional continuity. In the first type, the flattening of tooth crown which induces the removal of cusp interlocking occurs before the rotation of the chewing movement. In the second type however, flattening is subsequent to rotation of the chewing movement which can be associated with certain changes in cusp morphology. CONCLUSION/SIGNIFICANCE: The reverse orders of the changes involved in these different pathways reveal a mosaic evolution of mammalian dentition in which direction of chewing and crown shape seem to be partly decoupled. Either can change in respect to strong functional constraints affecting occlusion which thereby limit the number of the possible

  20. Cosmic Convergence: Art and Science

    Science.gov (United States)

    Mayo, Elizabeth A.; Zisholtz, E.; Hilton, H.

    2010-01-01

    The I.P. Stanback Museum and Planetarium is a major educational and teaching resource for South Carolina State University, K-12 schools, other universities and the community of Orangeburg and well beyond. The concept of creating a museum with a planetarium on the campus of SC State was ahead of its time. Today scholars are writing about the unity of creative disciplines. Through its integration of the arts, humanities and sciences, the Stanback, the only art museum with a planetarium at any of the Historically Black Colleges and Universities and one of the few in the nation, stands in the forefront of modern thinking. Cosmic Convergence: Art and Science, opening at the I.P. Stanback Museum and Planetarium in February 2010, will feature the works of Mildred Thompson (1936-2003), a prominent African American artist who worked in the media of painting, drawing, print making, sculpture, and photography. Thompson’s artwork shows the strong influences of her interest in physics, astronomy, and metaphysics as well as music and spiritualism. “My work in the visual arts is, and has always been, a continuous search for understanding. It is an expression of purpose and reflects a personal interpretation of the Universe.” Cosmic Convergence will explore the meeting of Art and Science through Mildred Thompson's work and the scientific basis of that work. The paintings and sculptures of the exhibit will be combined with astronomical images showing both the reality and interpretation of the surrounding Universe. Support for this work was provided by the NSF PAARE program to South Carolina State University under award AST-0750814.