WorldWideScience

Sample records for high axle loads

  1. A model for equivalent axle load factors

    OpenAIRE

    Amorim, Sara I.R.; Pais, Jorge; Vale, Aline C.; Minhoto, Manuel

    2014-01-01

    Most design methods for road pavements require the design traffic, based on the transformation of the traffic spectrum, to be calculated into a number of equivalent passages of a standard axle using the equivalent axle load factors. Generally, these factors only consider the type of axle (single, tandem or tridem), but they do not consider the type of wheel on the axles, i.e., single or dual wheel. The type of wheel has an important influence on the calculation of the design traffic. The exis...

  2. Effect of the load of drive axles and high of the curtain on stress-strain properties of the tractor

    Directory of Open Access Journals (Sweden)

    Tomáš Šmerda

    2007-01-01

    Full Text Available The goal of the experimental measurement was determination of relation among weight load of the tractor together, hitch height changes and drawbar characteristic. The measurement was realized on chassis dynamometer at MUAF in Brno. The first step consisted of rated speed characteristics measurement in conformity with OECD demands. The drawbar characteristic was measured under two selected gears. Adding 980 kg to the nominal wight of the tractor brought increasing maximal drawbar power and drawbar force together with decreasing of slip. The highest differences were observed during the mesurement of fifth gear shifted. The drawbar force grew up to 18.9% as well as the maximal drawbar power (15.2%. The maximal drawbar power at ninth gear gave 62.8 kW. The hitch height was setting to 0.54 m; 0.64 m and 0.74 m. When the hitch height was set from 0.54 m to 0.74 m the drawbar force an power on front axle was lower by reason of load reduction. As can be noticed from the final drawbar characteristics, both curves are identical up to border of maximal drawbar power. Small differences in the area of the highest slips can be ascribed to the rolling resistance.

  3. Capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints

    OpenAIRE

    2016-01-01

    In this paper, we introduce and study the capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints. To the best of our knowledge, it is the first time that axle weight restrictions are incorporated in a vehicle routing model. The aim of this paper is to demonstrate that incorporating axle weight restrictions in a vehicle routing model is possible and necessary for a feasible route planning. Axle weight limits impose a great challenge for transportatio...

  4. Dynamic Axle Load of an Automotive Vehicle When Driven on a Mobile Measurement Platform

    Directory of Open Access Journals (Sweden)

    Jagiełowicz-Ryznar C.

    2014-08-01

    Full Text Available An analysis of the dynamic axle load of an automotive vehicle (AV when it is driven on a mobile measurement platform is presented in this paper. During the ride, the time characteristic of the dynamic force N(t, acting on the axle, was recorded. The effect of the vehicle axle mass on the maximum dynamic force value and the dynamic coefficient were studied. On this basis it was attempted to calculate the total vehicle’s weight. Conclusions concerning the dynamic loads of the vehicle axles in relation to the reduced axle mass, were drawn. The optimal axle mass value, for which the dynamic coefficient reaches a minimum, was calculated

  5. DAMAGE TOLERANCE ANALYSIS ON HOLLOW AXLES OF HIGH SPEED MOTOR TRAINS

    Institute of Scientific and Technical Information of China (English)

    ZHOU Suxia; XIE Jilong; YANG Guangxue; XIAO Nan

    2008-01-01

    According to the rules of UIC515-3, the service loads of the axles are defined, which include some different loads cases as follows: the static loads; the impact loads resulted from running through the rail joints and unevenness rails; the loads through curves and from braking. Through the calculating and analysis, the stress distribution of the hollow axles is obtained for 200 km/h high speed motor trains used in China. At the same time, the fatigue crack growth of hollow axles is studied, and the initial surface cracks of 2 mm depth caused by hard objects strike or the other causes are discussed. On the basis of the linear elastic fracture mechanics theory, the stress intensity factor of the crack of the geometry transition outside the wheel seat is also studied. Associated with fatigue crack propagation equation and the corresponding crack propagation threshold, the crack propagation characteristics under different shapes are calculated. Then the running distances are educed with different shapes propagating to the critical length, and the estimation of the residual lives about hollow axles which are the reference values of examine and repair limit of the hollow axle is given.

  6. Prerequisites for Increasing the Axle Load on Railway Tracks in the Czech Republic

    Directory of Open Access Journals (Sweden)

    M. Lidmila

    2008-01-01

    Full Text Available This paper deals with problems of increasing the axle load on Czech Railways (ED tracks to 250 kN or 300 kN, respectively. The results of a numerical analysis of the effects of increased axle loads on the track bed structure were verified by experimental measurements carried out on track bed construction models in an experimental box on a 1:1 scale. The results of the research are applicable for routine use on ED. 

  7. Full-scale physical testing of a buried reinforced concrete pipe under axle load

    National Research Council Canada - National Science Library

    Lay, G.R; Brachman, R.W.I

    2014-01-01

    The structural response of a 600 mm inner diameter reinforced concrete pipe buried in a dense, well-graded sand and gravel soil and subjected to surface load from a single design truck axle with 0.3, 0.6...

  8. Determination of design axle loads for bridges from measurements

    NARCIS (Netherlands)

    Steenbergen, R.D.J.M.; Morales Napoles, O.

    2010-01-01

    Recently, the new Eurocode 1 was introduced dealing with traffic load on bridges. In order to establish the National Annex for the design traffic load, measurements of the traffic load were carried out in several highways in The Netherlands using the Weigh In Motion system. The goal was to assure

  9. Determination of design axle loads for bridges from measurements

    NARCIS (Netherlands)

    Steenbergen, R.D.J.M.; Morales Napoles, O.

    2010-01-01

    Recently, the new Eurocode 1 was introduced dealing with traffic load on bridges. In order to establish the National Annex for the design traffic load, measurements of the traffic load were carried out in several highways in The Netherlands using the Weigh In Motion system. The goal was to assure th

  10. Analysis of axle and vehicle load properties through Bayesian networks based on weigh-in-motion data

    NARCIS (Netherlands)

    Morales Napoles, O.; Steenbergen, R.D.J.M.

    2014-01-01

    Weigh-in-Motion (WIM) systems are used, among other applications, in pavement and bridge reliability. The system measures quantities such as individual axle load, vehicular loads, vehicle speed, vehicle length and number ofaxles. Because ofthe nature ofúamc configuration, the quantities measured are

  11. Analysis of axle and vehicle load properties through Bayesian networks based on weigh-in-motion data

    NARCIS (Netherlands)

    Morales Napoles, O.; Steenbergen, R.D.J.M.

    2014-01-01

    Weigh-in-Motion (WIM) systems are used, among other applications, in pavement and bridge reliability. The system measures quantities such as individual axle load, vehicular loads, vehicle speed, vehicle length and number ofaxles. Because ofthe nature ofúamc configuration, the quantities measured are

  12. Stress Analysis and Fatigue Analysis of Front Axle of Heavy-Duty Truck using ANSYS Ncode Design Life for Different Loading Cases

    Directory of Open Access Journals (Sweden)

    Hemant L. Aghav

    2016-06-01

    Full Text Available Front axle of heavy duty truck is the important component of vehicle and needs good design under the various loading conditions of the complete vehicle. Aim of the project is to stress analysis and predict the life of front axle for vertical, and vertical and braking loading case. The fatigue life of front axle is generally estimated by stress life approach and strain life approach method. Front axle beam assembly was modeled in the NX cad software. Meshing and Stress analysis is performed by ANSYS workbench and fatigue analysis is performed by NCODE design life ANSYS tool under different loading cases. Fatigue life of axle obtained by FEA method is more than 2 x 105 cycles, which is considered as safe for vertical loading case. Similarly, Fatigue life of axle obtained is more than 4 x 103 cycles, which is considered as safe for vertical and braking loading case. The max stress region is below spring pad of axle for vertical loading and in the goose neck of axle for vertical and braking loading case

  13. Experimental investigation by laser ultrasonics for high speed train axle diagnostics.

    Science.gov (United States)

    Cavuto, A; Martarelli, M; Pandarese, G; Revel, G M; Tomasini, E P

    2015-01-01

    The present paper demonstrates the applicability of a laser-ultrasonic procedure to improve the performances of train axle ultrasonic inspection. The method exploits an air-coupled ultrasonic probe that detects the ultrasonic waves generated by a high-power pulsed laser. As a result, the measurement chain is completely non-contact, from generation to detection, this making it possible to considerably speed up inspection time and make the set-up more flexible. The main advantage of the technique developed is that it works in thermo-elastic regime and it therefore can be considered as a non-destructive method. The laser-ultrasonic procedure investigated has been applied for the inspection of a real high speed train axle provided by the Italian railway company (Trenitalia), on which typical fatigue defects have been expressly created according to standard specifications. A dedicated test bench has been developed so as to rotate the axle with the angle control and to speed up the inspection of the axle surface. The laser-ultrasonic procedure proposed can be automated and is potentially suitable for regular inspection of train axles. The main achievements of the activity described in this paper are: – the study of the effective applicability of laser-ultrasonics for the diagnostic of train hollow axles with variable sections by means of a numerical FE model, – the carrying out of an automated experiment on a real train axle, – the analysis of the sensitivity to experimental parameters, like laser source – receiving probe distance and receiving probe angular position, – the demonstration that the technique is suitable for the detection of surface defects purposely created on the train axle. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Thermal Property Analysis of Axle Load Sensors for Weighing Vehicles in Weigh-in-Motion System

    Directory of Open Access Journals (Sweden)

    Piotr Burnos

    2016-12-01

    Full Text Available Systems which permit the weighing of vehicles in motion are called dynamic Weigh-in-Motion scales. In such systems, axle load sensors are embedded in the pavement. Among the influencing factors that negatively affect weighing accuracy is the pavement temperature. This paper presents a detailed analysis of this phenomenon and describes the properties of polymer, quartz and bending plate load sensors. The studies were conducted in two ways: at roadside Weigh-in-Motion sites and at a laboratory using a climate chamber. For accuracy assessment of roadside systems, the reference vehicle method was used. The pavement temperature influence on the weighing error was experimentally investigated as well as a non-uniform temperature distribution along and across the Weigh-in-Motion site. Tests carried out in the climatic chamber allowed the influence of temperature on the sensor intrinsic error to be determined. The results presented clearly show that all kinds of sensors are temperature sensitive. This is a new finding, as up to now the quartz and bending plate sensors were considered insensitive to this factor.

  15. Thermal Property Analysis of Axle Load Sensors for Weighing Vehicles in Weigh-in-Motion System.

    Science.gov (United States)

    Burnos, Piotr; Gajda, Janusz

    2016-12-15

    Systems which permit the weighing of vehicles in motion are called dynamic Weigh-in-Motion scales. In such systems, axle load sensors are embedded in the pavement. Among the influencing factors that negatively affect weighing accuracy is the pavement temperature. This paper presents a detailed analysis of this phenomenon and describes the properties of polymer, quartz and bending plate load sensors. The studies were conducted in two ways: at roadside Weigh-in-Motion sites and at a laboratory using a climate chamber. For accuracy assessment of roadside systems, the reference vehicle method was used. The pavement temperature influence on the weighing error was experimentally investigated as well as a non-uniform temperature distribution along and across the Weigh-in-Motion site. Tests carried out in the climatic chamber allowed the influence of temperature on the sensor intrinsic error to be determined. The results presented clearly show that all kinds of sensors are temperature sensitive. This is a new finding, as up to now the quartz and bending plate sensors were considered insensitive to this factor.

  16. 200 km/h 八轴客运电力机车轴重转移分析%Axle - load Transfer Analysis of 200 km/h Eight - axle Passenger Electric Locomotive

    Institute of Scientific and Technical Information of China (English)

    吕凯凯; 王开云; 张志和

    2015-01-01

    An axle - load transfer model for a new 200 km/ h eight - axle passenger electric locomotive is established in this paper. Comparisons between calculation results obtained from the established model and that from the commercial dynamic software under the quasi - static condition are made. Some factors that affect the locomotive axle - load transfer are analyzed. The result shows that the axle - load of the first axle and second axle are reducing,while for the third axle and fourth axle they are increasing. The maxi-mum load - increasing ratio is happened to the fourth axle,which is 6. 28 percent,and the maximum load- reducing ratio is for the first axle,which is also 6. 28 percent. The calculation result is similar to that by using the commercial dynamic software where the difference is only about 0. 8 percent. Compared with the traction motor suspended on wheel - set,the traction motor suspended on frame could reduce the axle- load transfer by about 5. 77 percent. The optimal traction height for the 200 km/ h eight - axle passen-ger electric locomotive is 260 mm. Reducing the distance between motor front and rear suspension points can improve the adhesion weight usage of a locomotive.%针对一种新型的200 km/ h 八轴客运电力机车,建立了轴重转移计算模型。利用该模型计算其轴重转移,与动力学软件在准静态条件下的仿真结果进行对比,并分析影响机车轴重转移的因素。研究表明,该机车第一、二轴为减载,第三、四轴为增载,且第四轴增载最大,增载6.28%,第一轴减载最大,减载6.28%;模型计算结果与动力学软件仿真结果相差0.8%;机车牵引电机采用架悬方式能有效减小机车轴重转移,相比电机采用轴悬方式,机车轴重转移减小5.77%;该机车最优牵引点高度为260 mm;减小电机前后悬挂点之间的纵向跨距能有效提高机车黏着重量利用率。

  17. Product Design and Production Practice of 700MPa High Strength Hot Rolled Strip for Auto Axle Tube

    Science.gov (United States)

    Hui, Pan; Zhao-dong, Wang; Ya-jun, Hui; Yang, Cui; Xiang-tao, Deng; Chun-lin, Bao

    According to the technical specifications of 700MPa high strength automotive axle tube steel, a low cost of 0.07%C+1.5%Mn+0.05%Nb+0.10%Ti was designed. The high strength mainly relies on grain refinement strengthening and precipitation strengthening. The recrystallization, precipitation, and CCT curves of the 700MPa grade axle tube steel were studied in order to determine a reasonable TMCP process. By controlling the low level segregation band, low level of C and N content, 700MPa grade high strength automotive axle tube steel is successfully developed with excellent mechanical property, welding property, flattening and flaring property, torsion fatigue property, static torsional property and surface quality.

  18. Cost-benefit analysis of the construction of different flexible pavement structures considering the axle load and type of binder

    Directory of Open Access Journals (Sweden)

    Lucas Dotto Bueno

    2016-08-01

    Full Text Available The status of Brazilian highways reflects a deficient pavement performance when they are subjected to loadings imposed by heavy traffic. Current legislation, as enacted by Contran (National Traffic Council, has increased the axle weight limit for cargo vehicles by up to 10%. Therefore, the aim of this study was to determine a cost-benefit ratio by using different types of structures, asphalt binders and load intensities. Typical pavements were determined and then analyzed by the software AEMC (SisPav to obtain the horizontal tensile strain (εt values at the bottom of the asphalt concrete layer and, later, the NFATIGUE value. It was found that the increase in weight, within values covered by legislation, might result in a reduction of approximately 50% in the NFATIGUE value for the pavement structures analyzed. As for economic impact, the same weight increase caused a mean increase of 120% in the cost of repeated loading on pavement structures (R$ NFATIGUE-1. It was also observed that structures with more robust asphalt concrete layers can provide the best R$ NFATIGUE-1 ratios. The best results for granular materials were found with thinner layers, associated with a thicker coating. The benefits of modified binders were shown by the analyses of the best structural options: both the polymer-modified binder and the rubber asphalt binder offer significant structural and economic improvements to the structure.

  19. WHEELSET AXLE WITH THE CAVITY OF UNIFORM CROSS SECTION

    Directory of Open Access Journals (Sweden)

    S. R. Kolesnykov

    2014-10-01

    Full Text Available Purpose. Due to operation in complex loading conditions, the rolling stock wheelsets should provide high reliability, since the train traffic safety largely depends on them. Design and technical condition of wheelsets affect the smoothness, intensity of forces generated by the interaction between the car and track, and the motion resistance. Specificity of the axle operation consists in the fact that it undergoes the bending stresses under loading. These stresses are unevenly distributed along the cross-sectional area, reaching the highest values in the outer fibers and the minimal values in the internal ones. This aspect sets the problem of replacement of the uniform cross section with the hollow cross section. The disadvantages of hollow axle design, which are used at the present time, should include a significant manufacturing complexity of the variable section cavity. The purpose is to develop a modernized design of the wheelset axle. Methodology. A construction of the hollow axle having an inner longitudinal cylindrical through hole of the constant diameter throughout its length was proposed. The item is made of steel seamless tube. The inner surface of the tube is treated by mechanical means to remove the voltage concentrations in the internal longitudinal cylindrical through hole, which has a constant diameter along the entire length of the axle. Findings. Application of this design will facilitate manufacturing of the hollow axle and the machining of the inner longitudinal through hole, while retaining all the use advantages of the hollow axle in the rolling stock wheel pairs. Another use advantage of the hollow axle of this design is the absence of partial heterogeneity of the metal, which is inevitably, occurs during the solid axles blanking. Originality. A new design of the wheelset hollow axle of railway rolling stock was proposed. Practical value. Introduction of the new design simplifying the manufacture and mechanical treatment of

  20. Dynamic Response Characteristics of Asphalt Pavement Under Multi-axle Moving Load%多轴移动荷载下沥青路面的动态响应特性

    Institute of Scientific and Technical Information of China (English)

    裴建中; 吴浩; 陈勇; 王秉纲

    2011-01-01

    In order to analyze dynamic response characteristics of asphalt pavement under muhi axle moving load,a three-dimensional finite element model of asphalt pavement was established by field investigation. The influences of axle load with uniform distribution of single rear axle, dual rear axles and three rear axles and the axle load with non-uniform distribution of three rear axles and the three rear axles vehicles with impending front axle on pavement were studied respectively. Results show that the effect of each axle on pavement is independent when the wheelbase of multi axle vehicle is bigger than 3 m. Increase of number of axle makes the vertical displacement of pavement superpose and makes the maximal shear stress and compressive stress of pavement change inconspicuously. The influence of the middle axle of three rear axles vehicle on the vertical displacement of pavement is the greatest which increases by 23. 7% and 18. 2% compared with those of the front axle and rear axle respectively. Besides, the middle axle and rear axle has certain influence on the shear stress of pavement, but each axle has ahnost no influence on the maximal compressive stress of pavement. The research results indicate that the non uniform distribution of axle load of multi axle vehicle has significant influence on pavement faliure.%为分析多轴移动荷载下沥青路面的动态响应特性,通过现场调查建立了不同轴型作用下沥青路面的三维有限元模型,分别研究了单后轴、双后轴及三后轴轴载均匀分布、三后轴车轴载不均匀分布及三后轴车前轴悬空条件下对路面的影响。结果表明:多轴车轴距大于3m时,各轴对路面的作用相互独立,轴数的增加对路面竖向位移产生叠加作用,对路表最大剪应力及压应力影响不明显;三后轴车中轴对路面竖向位移作用最大,较前轴及后轴分别增大23.7%和18.2%,中轴及后轴对路表剪应力有一定影响,

  1. Fatigue of bridges with a horizontal rotation axle under random wind load

    NARCIS (Netherlands)

    Maljaars, J.; Steenbergen, R.D.J.M.

    2012-01-01

    The operating mechanisms of movable bridges are subjected to various types of fluctuating loads which may induce fatigue damage. Wind load acting on the bridge deck - when the bridge is open - is one of the important load types. A wind load model is proposed that can be used in the fatigue design ve

  2. The Effect of Flexible Pavement Mechanics on the Accuracy of Axle Load Sensors in Vehicle Weigh-in-Motion Systems.

    Science.gov (United States)

    Burnos, Piotr; Rys, Dawid

    2017-09-07

    Weigh-in-Motion systems are tools to prevent road pavements from the adverse phenomena of vehicle overloading. However, the effectiveness of these systems can be significantly increased by improving weighing accuracy, which is now insufficient for direct enforcement of overloaded vehicles. Field tests show that the accuracy of Weigh-in-Motion axle load sensors installed in the flexible (asphalt) pavements depends on pavement temperature and vehicle speeds. Although this is a known phenomenon, it has not been explained yet. The aim of our study is to fill this gap in the knowledge. The explanation of this phenomena which is presented in the paper is based on pavement/sensors mechanics and the application of the multilayer elastic half-space theory. We show that differences in the distribution of vertical and horizontal stresses in the pavement structure are the cause of vehicle weight measurement errors. These studies are important in terms of Weigh-in-Motion systems for direct enforcement and will help to improve the weighing results accuracy.

  3. REDESIGNING OF TRACTOR TROLLEY AXLE USING ANSYS

    Directory of Open Access Journals (Sweden)

    Harish V. Katore,

    2011-06-01

    Full Text Available In Central India, various small scale industries are adopting the crude methodologies for designing & manufacturing the machine components. One such industry producing tractor trolleys for agricultural use has been identified for this study. The existing trolley designed by the industry uses heavy axle without consideringstatic and dynamic loading conditions which in turn leads to higher factor of safety increasing the overall cost of the axle. In this study, existing trolley axle is redesigned considering the static and dynamic load conditions. A CAD model is prepared using CATIA V5 as a tool. Minimum cross section for the axle is calculated which resulted in the 24.8 % reduction in the weight of the axle. The axle dimensions are redesigned to 75 X 75 mm which is comparatively smaller than the old axle. The design is optimized based on the manufacturing cost of the axle. The failure analysis is performed on the axle of trolley used in agricultural area. These results provide atechnical basis to prevent future damage to the location axle.

  4. CONOCOPHILLIPS FUEL EFFICIENT HIGH-PERFORMANCE(FEHP) SAE 75W90 REAR AXLE GEAR LUBRICANT

    Science.gov (United States)

    This report is on the Environmental Verification Test of a ConocoPhillips real axle gear lubricant to determine whether it could save vehicle fuel. It determined that a verifyable fuel savings could be measured.

  5. 高速公路路段交通量分析及轴载换算%Analysis of Traffic Volume and Equivalent Axle Load Factors in Freeway Sections

    Institute of Scientific and Technical Information of China (English)

    朱靓雯; 刘黎萍

    2016-01-01

    交通荷载数据对沥青路面设计和管理有重要作用。轴载谱方法可以更为全面、准确地描述交通荷载。文中收集了江西省部分高速公路荷载站点的实测轴载数据和交通量数据。通过对每一辆车进出收费站的名称识别,结合公路网分布统计得到各路段的交通荷载数据集合。对各路段实测轴载数据特征、交通增长率和累计标准轴次等进行分析,建立了轴载谱数据和交通量数据之间的关系,并给出了调查地区的当量轴次换算系数参考值。%Traffic loading data is very important for asphalt pavement design and management.Axle load spectrum is more comprehensive and accurate in describing the traffic load.This study collected the measured axle load data and traffic volume data of asphalt pavement freeways from toll gates in Jiangxi Province.Traffic loading data in freeway sections is obtained through the data from the en-trance and exit toll gate,combined with the highway network.The data was used to analyze the axle load spectrum factors,the number of accumulated equivalent axle loads,and the growth rate of equiv-alent axle loads.It has been found that the growth rate of equivalent axle loads in some highway sec-tions is negative.In addition,the relationship between axle load data and traffic volume data was de-veloped through the equivalent axle load factors,the value of which in investigated area was listed at last.

  6. Nonlinearity-induced time-varying harmonic dynamic axle load and its impact on dynamic stability of car-trailer combinations

    Science.gov (United States)

    Zhang, Ning; Xiao, Hong; Winner, Hermann

    2016-06-01

    A nonlinearity-induced time-varying harmonic dynamic axle load is found in the road test of a car-trailer combination. To understand its influence on system dynamic stability, a corresponding linear single-track model (STM) is proposed. System dynamic stability is described and sensitivity analysis for the system parameters is achieved. The contribution of the harmonic force is quantified by a derived effective axle load. Because the harmonic effect might be time varying in practice, a time-frequency analysis-based parameter identification method is introduced. Experimental study shows that a time-varying harmonic effect really exists. A yaw-rate-based simulation method is designed to simulate this behaviour. The sensitivity analysis of the influence of the harmonic amplitude or phase on dynamic stability is performed with a simulation study. With appropriate modification of the harmonic amplitude and phase shift applied in selected time windows, the time-varying system characteristics in the road test can be simulated very well.

  7. 联合收割机行走半轴载荷测试系统构建与性能试验%Construction and performance experiment of load test system for half axle of combine harvester

    Institute of Scientific and Technical Information of China (English)

    李耀明; 叶晓飞; 徐立章; 庞靖; 马征

    2013-01-01

    Half axle is an important part of a walking system in a combine harvester;the damage from half axle is generally fatigue failure, which has a direct effect on the reliability and stability of the combine harvester. Minority combine harvester manufacturers have half axle fatigue test rigs, and most of the loads on the fatigue test rig are set artificially, thus it cannot accurately predict fatigue life of half axle in absence of comprehensive consideration of various alternating loads. Fatigue life analysis and fast in doors simulation of the load fatigue test on the basis of load spectrum can provide the basis for the improvement of half axle. Improvement of fatigue performance of half axle is conducive to the competitiveness of the products on the market at home and abroad. It is not a suitable solution to use traditional shaft or disc torque sensors to test the torque of half axle, because the half axle is closed in the transmission. Operating environments of combine harvesters are complex, and half axles often bear a complex alternating load which puts forward higher requirements on the stability and reliability of the performance of the load test system. To provide a precise and comprehensive load-time course for the compiling of load spectrum of the half axle of a combine harvester, the complex and alternating load signal in typical working conditions must be acquired accurately. Based on an analysis of working characteristics and the construction features of chassis of combine harvesters, a wireless load test system was put forward in this paper by choosing reasonable torque and rotation speed sensors and data acquisition systems composed of hall sensors, rotation speed signal acquisition modules, resistance strain gauges, power modules, torque signal acquisition modules, wireless routers, computers, and software for signals test and analysis. In order to exclude the influence of measured value of torque signals by bending moment, axial force, and temperature

  8. Imaging Axl expression in pancreatic and prostate cancer xenografts

    Energy Technology Data Exchange (ETDEWEB)

    Nimmagadda, Sridhar, E-mail: snimmag1@jhmi.edu [Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287 (United States); Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287 (United States); Pullambhatla, Mrudula; Lisok, Ala [Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287 (United States); Hu, Chaoxin [Department of Pathology, Johns Hopkins University, Baltimore, MD 21287 (United States); Maitra, Anirban [Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287 (United States); Department of Pathology, Johns Hopkins University, Baltimore, MD 21287 (United States); Pomper, Martin G, E-mail: mpomper@jhmi.edu [Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287 (United States); Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287 (United States)

    2014-01-10

    Highlights: •Axl is overexpressed in a variety of cancers. •Axl overexpression confers invasive phenotype. •Axl imaging would be useful for therapeutic guidance and monitoring. •Axl expression imaging is demonstrated in pancreatic and prostate cancer xenografts. •Graded levels of Axl expression imaging is feasible. -- Abstract: The receptor tyrosine kinase Axl is overexpressed in and leads to patient morbidity and mortality in a variety of cancers. Axl–Gas6 interactions are critical for tumor growth, angiogenesis and metastasis. The goal of this study was to investigate the feasibility of imaging graded levels of Axl expression in tumors using a radiolabeled antibody. We radiolabeled anti-human Axl (Axl mAb) and control IgG1 antibodies with {sup 125}I with high specific radioactivity and radiochemical purity, resulting in an immunoreactive fraction suitable for in vivo studies. Radiolabeled antibodies were investigated in severe combined immunodeficient mice harboring subcutaneous CFPAC (Axl{sup high}) and Panc1 (Axl{sup low}) pancreatic cancer xenografts by ex vivo biodistribution and imaging. Based on these results, the specificity of [{sup 125}I]Axl mAb was also validated in mice harboring orthotopic Panc1 or CFPAC tumors and in mice harboring subcutaneous 22Rv1 (Axl{sup low}) or DU145 (Axl{sup high}) prostate tumors by ex vivo biodistribution and imaging studies at 72 h post-injection of the antibody. Both imaging and biodistribution studies demonstrated specific and persistent accumulation of [{sup 125}I]Axl mAb in Axl{sup high} (CFPAC and DU145) expression tumors compared to the Axl{sup low} (Panc1 and 22Rv1) expression tumors. Axl expression in these tumors was further confirmed by immunohistochemical studies. No difference in the uptake of radioactivity was observed between the control [{sup 125}I]IgG1 antibody in the Axl{sup high} and Axl{sup low} expression tumors. These data demonstrate the feasibility of imaging Axl expression in pancreatic

  9. Shape Optimization Of Front Axle Support Of Tractor

    Directory of Open Access Journals (Sweden)

    Shree Dewangan

    2014-04-01

    Full Text Available The front axle support of tractor is the part of tractor which holds the engine of tractor and also gives support to it and lies between engine and front axle of tractor. According to the present market demand of off highway vehicle the low cost and light weight vehicle is in demand to fulfill the requirement of cost efficient vehicle. In this paper analysis of front axle support is done for study of stress generated in the component and then after optimization of its shape and according to the shape its weight will also reduced. Considering the effect of forces acted on such a heavy parts in tractor designed by casting having dynamic loads of less frequency with greater amplitude may cause great damage to the component. According to the production techniques of components in tractor front axle requires a properly designed support with high stiffness. The design of component was modeled in Creo parametric 2.0 and the analysis was performed in solid works. Shape optimization technique is used for performing optimization cause miserable reduction in weight of connecting rod. The optimized component is 10.35% lighter compare to initial design.

  10. Influence of Initial Inclined Surface Crack on Estimated Residual Fatigue Lifetime of Railway Axle

    Science.gov (United States)

    Náhlík, Luboš; Pokorný, Pavel; Ševčík, Martin; Hutař, Pavel

    2016-11-01

    Railway axles are subjected to cyclic loading which can lead to fatigue failure. For safe operation of railway axles a damage tolerance approach taking into account a possible defect on railway axle surface is often required. The contribution deals with an estimation of residual fatigue lifetime of railway axle with initial inclined surface crack. 3D numerical model of inclined semi-elliptical surface crack in railway axle was developed and its curved propagation through the axle was simulated by finite element method. Presence of press-fitted wheel in the vicinity of initial crack was taken into account. A typical loading spectrum of railway axle was considered and residual fatigue lifetime was estimated by NASGRO approach. Material properties of typical axle steel EA4T were considered in numerical calculations and lifetime estimation.

  11. 基于轴荷平衡的双联轴货车钢板平衡悬架参数优化%Parameter Optimization of the Leaf-spring Balanced Suspension in a Tandem Axle Truck Based on Axle-load Balance

    Institute of Scientific and Technical Information of China (English)

    胡延平; 宋东奇; 陈一锴; 张卫华; 柏海舰

    2015-01-01

    [ Abstract] For thoroughly improving the overall driving performance of tandem-axle truck,a parameter optimiza-tion scheme for the leaf-spring balanced suspension of a tandem axle truck is proposed with consideration of dynamic axle load balance. Firstly a six DOF half-vehicle model with leaf-spring balanced suspension and a single-rut random excita-tion time-domain model are created respectively based on numerical analysis, and a corresponding dynamic vehicle-road coupled model is also built with MATLAB/Simulink accordingly. Then an overall driving performance indicator of tandem axle truck is put forward, which comprehensively reflect the dynamic axle load balance and ride comfort of vehicle and the degree of influence of suspension parameters on the overall driving performance of vehicle is explored based on orthog-onal experiment. Finally a thorough optimization of key suspension parameters is achieved by range analysis and variance analysis. The results indicate that compared with original truck, the overall driving performance indicator of truck after parameter optimization is enhanced by some 30% at the speed range of 20 to 90km/h.%为全面改善双联轴货车的综合行驶性能,提出一种考虑动态轴荷平衡的货车双联轴钢板平衡悬架参数优化方法。首先,基于数值分析法分别建立带钢板平衡悬架的6自由度1/2车辆模型和单轮辙随机激励时域模型,并在MATLAB/Simulink中构建相应的车路耦合动力学模型。进而提出综合反映动态轴荷平衡和平顺性的多联轴货车综合行驶性能指标,依据正交试验探索悬架各参数对车辆综合行驶性能的影响程度。最后通过极差和方差分析实现悬架关键参数的全面优化。结果表明,在20~90km/h车速下,相对于原货车,参数优化后货车的综合行驶性能指标约提高了30%。

  12. Application of Computational-Experimental Methods for Designing Optimized Semitrailer Axle Supports

    Directory of Open Access Journals (Sweden)

    David Valladares

    2015-01-01

    Full Text Available Computational and experimental methods were applied to the design and optimization of a semitrailer axle support subjected to fatigue loads. Numerical results based on the finite element method (FEM were correlated with extensometric tests to assess the accuracy of the computational method. This paper is focused on the “minimum radius manoeuvre.” This situation represents the highly critical load case occurring in a semitrailer operation where the tractor vehicle pulls the semitrailer's kingpin at approximately 90° with respect to its longitudinal axis, and high stress and strain phenomena take place in the axle supports’ structure. Loads and boundary conditions that correspond to this load case were first adjusted by means of experimental tests and could be later applied to each semitrailer axle support in the numerical model. In this analysis, the stress-strain elastic-plastic curves of the base material, the welding, and the HAZ have been incorporated to the numerical models. Fatigue S-N curves combined with the maximum Von Mises equivalent stresses obtained in the computational analysis provided a maximum number of cycles that the semitrailer axle support could reach in case of the minimum radius manoeuvre being applied to the vehicle in a repeated manner. The initial design could then be optimized to improve its fatigue life.

  13. High Power Disk Loaded Guide Load

    Energy Technology Data Exchange (ETDEWEB)

    Farkas, Z.D.; /SLAC

    2006-02-22

    A method to design a matching section from a smooth guide to a disk-loaded guide, using a variation of broadband matching, [1, 2] is described. Using this method, we show how to design high power loads. The load consists of a disk-loaded coaxial guide operating in the TE{sub 01}-mode. We use this mode because it has no electric field terminating on a conductor, has no axial currents, and has no current at the cylinder-disk interface. A high power load design that has -35 dB reflection and a 200 MHz, -20 dB bandwidth, is presented. It is expected that it will carry the 600 MW output peak power of the pulse compression network. We use coaxial geometry and stainless steel material to increase the attenuation per cell.

  14. Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum.

    Science.gov (United States)

    Budagian, Vadim; Bulanova, Elena; Orinska, Zane; Duitman, Erwin; Brandt, Katja; Ludwig, Andreas; Hartmann, Dieter; Lemke, Greg; Saftig, Paul; Bulfone-Paus, Silvia

    2005-11-01

    Axl receptor tyrosine kinase exists as a transmembrane protein and as a soluble molecule. We show that constitutive and phorbol 12-myristate 13-acetate-induced generation of soluble Axl (sAxl) involves the activity of disintegrin-like metalloproteinase 10 (ADAM10). Spontaneous and inducible Axl cleavage was inhibited by the broad-spectrum metalloproteinase inhibitor GM6001 and by hydroxamate GW280264X, which is capable of blocking ADAM10 and ADAM17. Furthermore, murine fibroblasts deficient in ADAM10 expression exhibited a significant reduction in constitutive and inducible Axl shedding, whereas reconstitution of ADAM10 restored sAxl production, suggesting that ADAM10-mediated proteolysis constitutes a major mechanism for sAxl generation in mice. Partially overlapping 14-amino-acid stretch deletions in the membrane-proximal region of Axl dramatically affected sAxl generation, indicating that these regions are involved in regulating the access of the protease to the cleavage site. Importantly, relatively high circulating levels of sAxl are present in mouse sera in a heterocomplex with Axl ligand Gas6. Conversely, two other family members, Tyro3 and Mer, were not detected in mouse sera and conditioned medium. sAxl is constitutively released by murine primary cells such as dendritic and transformed cell lines. Upon immobilization, sAxl promoted cell migration and induced the phosphorylation of Axl and phosphatidylinositol 3-kinase. Thus, ADAM10-mediated generation of sAxl might play an important role in diverse biological processes.

  15. Soluble Axl Is Generated by ADAM10-Dependent Cleavage and Associates with Gas6 in Mouse Serum†

    Science.gov (United States)

    Budagian, Vadim; Bulanova, Elena; Orinska, Zane; Duitman, Erwin; Brandt, Katja; Ludwig, Andreas; Hartmann, Dieter; Lemke, Greg; Saftig, Paul; Bulfone-Paus, Silvia

    2005-01-01

    Axl receptor tyrosine kinase exists as a transmembrane protein and as a soluble molecule. We show that constitutive and phorbol 12-myristate 13-acetate-induced generation of soluble Axl (sAxl) involves the activity of disintegrin-like metalloproteinase 10 (ADAM10). Spontaneous and inducible Axl cleavage was inhibited by the broad-spectrum metalloproteinase inhibitor GM6001 and by hydroxamate GW280264X, which is capable of blocking ADAM10 and ADAM17. Furthermore, murine fibroblasts deficient in ADAM10 expression exhibited a significant reduction in constitutive and inducible Axl shedding, whereas reconstitution of ADAM10 restored sAxl production, suggesting that ADAM10-mediated proteolysis constitutes a major mechanism for sAxl generation in mice. Partially overlapping 14-amino-acid stretch deletions in the membrane-proximal region of Axl dramatically affected sAxl generation, indicating that these regions are involved in regulating the access of the protease to the cleavage site. Importantly, relatively high circulating levels of sAxl are present in mouse sera in a heterocomplex with Axl ligand Gas6. Conversely, two other family members, Tyro3 and Mer, were not detected in mouse sera and conditioned medium. sAxl is constitutively released by murine primary cells such as dendritic and transformed cell lines. Upon immobilization, sAxl promoted cell migration and induced the phosphorylation of Axl and phosphatidylinositol 3-kinase. Thus, ADAM10-mediated generation of sAxl might play an important role in diverse biological processes. PMID:16227584

  16. Giving AXL the axe: targeting AXL in human malignancy

    Science.gov (United States)

    Gay, Carl M; Balaji, Kavitha; Byers, Lauren Averett

    2017-01-01

    The receptor tyrosine kinase AXL, activated by a complex interaction between its ligand growth arrest-specific protein 6 and phosphatidylserine, regulates various vital cellular processes, including proliferation, survival, motility, and immunologic response. Although not implicated as an oncogenic driver itself, AXL, a member of the TYRO3, AXL, and MERTK family of receptor tyrosine kinases, is overexpressed in several haematologic and solid malignancies, including acute myeloid leukaemia, non-small cell lung cancer, gastric and colorectal adenocarcinomas, and breast and prostate cancers. In the context of malignancy, evidence suggests that AXL overexpression drives wide-ranging processes, including epithelial to mesenchymal transition, tumour angiogenesis, resistance to chemotherapeutic and targeted agents, and decreased antitumor immune response. As a result, AXL is an attractive candidate not only as a prognostic biomarker in malignancy but also as a target for anticancer therapies. Several AXL inhibitors are currently in preclinical and clinical development. This article reviews the structure, regulation, and function of AXL; the role of AXL in the tumour microenvironment; the development of AXL as a therapeutic target; and areas of ongoing and future investigation. PMID:28072762

  17. Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia.

    Directory of Open Access Journals (Sweden)

    Gareth D Hyde

    Full Text Available Chronic kidney disease (CKD is defined as the progressive loss of renal function often involving glomerular, tubulo-interstitial and vascular pathology. CKD is associated with vascular calcification; the extent of which predicts morbidity and mortality. However, the molecular regulation of these events and the progression of chronic kidney disease are not fully elucidated. To investigate the function of Axl receptor tyrosine kinase in CKD we performed a sub-total nephrectomy and fed high phosphate (1% diet to Axl+/+ and Axl-/- mice. Plasma Gas6 (Axl' ligand, renal Axl expression and downstream Akt signalling were all significantly up-regulated in Axl+/+ mice following renal mass reduction and high phosphate diet, compared to age-matched controls. Axl-/- mice had significantly enhanced uraemia, reduced bodyweight and significantly reduced survival following sub-total nephrectomy and high phosphate diet compared to Axl+/+ mice; only 45% of Axl-/- mice survived to 14 weeks post-surgery compared to 87% of Axl+/+ mice. Histological analysis of kidney remnants revealed no effect of loss of Axl on glomerular hypertrophy, calcification or renal sclerosis but identified significantly increased tubulo-interstitial apoptosis in Axl-/- mice. Vascular calcification was not induced in Axl+/+ or Axl-/- mice in the time frame we were able to examine. In conclusion, we identify the up-regulation of Gas6/Axl signalling as a protective mechanism which reduces tubulo-interstitial apoptosis and slows progression to end-stage renal failure in the murine nephrectomy and high phosphate diet model of CKD.

  18. Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia.

    Science.gov (United States)

    Hyde, Gareth D; Taylor, Rebecca F; Ashton, Nick; Borland, Samantha J; Wu, Hon Sing Geoffrey; Gilmore, Andrew P; Canfield, Ann E

    2014-01-01

    Chronic kidney disease (CKD) is defined as the progressive loss of renal function often involving glomerular, tubulo-interstitial and vascular pathology. CKD is associated with vascular calcification; the extent of which predicts morbidity and mortality. However, the molecular regulation of these events and the progression of chronic kidney disease are not fully elucidated. To investigate the function of Axl receptor tyrosine kinase in CKD we performed a sub-total nephrectomy and fed high phosphate (1%) diet to Axl+/+ and Axl-/- mice. Plasma Gas6 (Axl' ligand), renal Axl expression and downstream Akt signalling were all significantly up-regulated in Axl+/+ mice following renal mass reduction and high phosphate diet, compared to age-matched controls. Axl-/- mice had significantly enhanced uraemia, reduced bodyweight and significantly reduced survival following sub-total nephrectomy and high phosphate diet compared to Axl+/+ mice; only 45% of Axl-/- mice survived to 14 weeks post-surgery compared to 87% of Axl+/+ mice. Histological analysis of kidney remnants revealed no effect of loss of Axl on glomerular hypertrophy, calcification or renal sclerosis but identified significantly increased tubulo-interstitial apoptosis in Axl-/- mice. Vascular calcification was not induced in Axl+/+ or Axl-/- mice in the time frame we were able to examine. In conclusion, we identify the up-regulation of Gas6/Axl signalling as a protective mechanism which reduces tubulo-interstitial apoptosis and slows progression to end-stage renal failure in the murine nephrectomy and high phosphate diet model of CKD.

  19. Accumulative deformation in railway track induced by high-speed traffic loading of the trains

    Institute of Scientific and Technical Information of China (English)

    Bian Xuecheng; Jiang Hongguang; Chen Yunmin

    2010-01-01

    Prediction and control of the permanent settlement of a track caused by traffic loading from trains is crucial to high-speed railway design and maintenance. In this study, a unified prediction model of accumulative deformation of geomaterials used in railway construction subjected to cyclic loadings is introduced and calibrated using physical model testing. Based on this versatile model, a calculation approach to determine the track structure settlement under repeated loadings caused by the movement of the wheel axle of the train is proposed. Regression analysis on the physical model testing is adopted to determine the parameters involved in the computational approach. Comparison of model test data and computed results shows that the parameters obtained from the back-analysis are consistent throughout the various testing conditions, and the proposed calculation approach is capable of satisfactorily predicting the accumulative settlement of the railway roadbed and subgrade soil for various axle loads and loading cycles. A case study of a high-speed railway is performed to demonstrate the feasibility of the proposed approach in realistic engineering applications. The computation results from the settlement development of a roadbed and subgrade soil are presented and discussed.

  20. Rotation of artificial rotor axles in rotary molecular motors

    National Research Council Canada - National Science Library

    Baba, Mihori; Iwamoto, Kousuke; Iino, Ryota; Ueno, Hiroshi; Hara, Mayu; Nakanishi, Atsuko; Kishikawa, Jun-ichi; Noji, Hiroyuki; Yokoyama, Ken

    2016-01-01

    [F.sub.1]- and [V.sub.1]-ATPase are rotary molecular motors that convert chemical energy released upon ATP hydrolysis into torque to rotate a central rotor axle against the surrounding catalytic stator cylinder with high efficiency...

  1. Expression of Axl in Lung Adenocarcinoma and Correlation with Tumor Progression

    Directory of Open Access Journals (Sweden)

    Yi-Shing Shinh

    2005-12-01

    Full Text Available We used the Transwell system to select highly invasive cell lines from minimally invasive parent cells, and we compared gene expression in paired cell lines with high and low invasive potentials. Axl was relatively overexpressed in the highly invasive cell lines when compared with their minimally invasive counterparts. However, there is only limited information about the role of Axl in cancer invasion. The biologic function of Axl in tumor invasion was investigated by overexpression of full-length Axl in minimally invasive cells and by siRNA knockdown of Axl expression in highly invasive cells. Overexpression of Axl in minimally invasive cells increased their invasiveness. siRNA reduced cell invasiveness as Axl was downregulated in highly invasive cells. We further investigated the protein expression of Axl by immunohistochemistry and its correlation with clinicopathologic features. Data from a study of 58 patient specimens showed that Axl immunoreactivity was statistically significant with respect to lymph node status (P < .0001 and the patient's clinical stage (P < .0001. Our results demonstrate that Axl protein kinase seems to play an important role in the invasion and progression of lung cancer.

  2. Simulation Research on Stress Intensity Factors of Different Crack Aspect Ratios on Hollow Axles

    Institute of Scientific and Technical Information of China (English)

    ZHOU Suxia; XIE Jilong

    2009-01-01

    Because of the wicked service environment of the high speed train, it is possible that the hollow axle of the train may encounter the foreign object damage and form a sharp notch. Under the fatigue loading a crack can initiate from the notch and propagate to failure. It is noted that the stress intensity factor is the control parameter of the crack propagating, for the purpose of getting the more exact propagation characteristics, the stress intensity factor is studied mainly. The service loads of hollow axles are defined, and the stress distribution of hollow axles is obtained according to the load spectrum. The semi-ellipse crack configuration is defined with three parameters:the aspect ratio, the relative depth and the relative location along the crack front. Quarter point 20-node isoparametric degenerate singular elements are used for the region near the crack tip. The finite element model of crack extension of hollow axle is created, and the crack front is dispersed which can realize orthogonal extension. Based on this the stress intensity factors of crack front were calculated, and the distribution rules of the stress intensity factors of different initial crack shapes are obtained. The conclusions are compared with that of the analytic method and they agree with each other very well, and the calculating results show that there is a close relationship between the stress intensity factor and the initial crack shape. For a round crack the stress intensity factor at the surface point increases faster than the one at the center point with the crack propagation. However, for a narrow crack, the results are in contrast with that of a round one. So, all the cracks with different shapes propagate toward to a similar shape, and they grow at this shape to end. The study may contribute to the crack propagate characteristics research.

  3. Axl is not an indispensable factor for Zika virus infection in mice.

    Science.gov (United States)

    Wang, Zhao-Yang; Wang, Zai; Zhen, Zi-Da; Feng, Kai-Hao; Guo, Jing; Gao, Na; Fan, Dong-Ying; Han, Dai-Shu; Wang, Pei-Gang; An, Jing

    2017-08-01

    Recently, Zika virus (ZIKV) outbreak has been associated with a sharp increase in cases of Guillain-Barré syndrome and severe fetal abnormalities. However, the mechanism underlying the interaction of ZIKV with host cells is not yet clear. Axl, a receptor tyrosine kinase, is postulated as a receptor for ZIKV entry; however, its in vivo role during ZIKV infection and its impact on the outcome of the disease have not been fully characterized and evaluated. Moreover, there are contradictory results on its involvement in ZIKV infection. Here we utilized Axl-deficient mice (Axl-/-) and their littermates (Axl+/-) to study the in vivo role of Axl in ZIKV infection. Our results showed that both Axl+/- and Axl-/- suckling mice supported the replication of ZIKV and presented clinical manifestations. No significant difference has been found between Axl-deficient mice and their littermates in terms of the survival rate, clinical manifestations, viral load, ZIKV distribution and histopathological changes in major organs. These results therefore indicate that Axl is not an indispensable factor for ZIKV infection in mice.

  4. Monitoring of the Structural Integrity of Wheelset Axles Using Guided Waves

    OpenAIRE

    Grzeszkowski, Mateusz; Prager, Jens

    2014-01-01

    International audience; The structural integrity of wheelset axles of high speed trains as well as freight wagons is of major importance for safety of rail transport. Up to now the inspection of wheelset axles is part of a periodic maintenance which is expensive due to long inspection times and highly influenced by the human factor, especially if those inspections are carried out during night time. Permanently installed SHM-systems at each axle would be able to monitor the structural integrit...

  5. Analysis of Tendencies Towards Changes in Temperatures of Railway Vehicle Axle Boxes

    Directory of Open Access Journals (Sweden)

    Olegas Lunys

    2012-11-01

    Full Text Available The paper analyzes variations in the temperature of axle-box heating of railroad rolling stock considering two modes of the train - driving and parking position. Additionally, the article describes the influence of the axle load and season on the heat of the axle-box, forecasts intolerable residual resources and explains a possibility of detecting likely breakage at the very beginning of defects. The paper also deals with scientific literature related to axle-box heating and focuses on the conducted practical and theoretical experiments. The carried out research has established the rates of operating heating and critical heating. The application of numerical values for the algorithm of automatic control devices could help with detecting the breakdowns of the axle-box before they reach a critical state and assist in forecasting residual operating resources.

  6. TE(01) High Power Disk Loaded Guide Load

    CERN Document Server

    Farkas, Zoltan D

    2005-01-01

    A method to design a matching section from a smooth guide to a disk loaded guide, using a variation of broadband matching* is described. Using this method, we show how to design high power loads, filters and attenuators. The load consists of a disk loaded coaxial guide, operating in the T01

  7. Soluble AXL: a possible circulating biomarker for neurofibromatosis type 1 related tumor burden.

    Science.gov (United States)

    Johansson, Gunnar; Peng, Po-Chun; Huang, Po-Yuan; Chien, Hsiung-Fei; Hua, Kuo-Tai; Kuo, Min-Liang; Chen, Chin-Tin; Lee, Ming-Jen

    2014-01-01

    Neurofibromatosis type 1 (NF1) is the most common tumor predisposition disorder affecting 1/3500 worldwide. Patients are at risk of developing benign (neurofibromas) and malignant peripheral nerve sheath tumors (MPNST). The AXL receptor tyrosine kinase has been implicated in several kinds of cancers, but so far no studies have investigated the role of AXL in NF1 related tumorigenesis. Recently, the soluble fraction from the extracellular domain of AXL (sAXL) has been found in human plasma, and its level was correlated to poor prognosis in patients with renal cancer. Compared to normal human Schwann cells, a significantly high expression level of AXL was found in three of the four MPNST cell lines and two of the three primary MPNST tissues. Similarly, the level of sAXL in conditioned media corresponded to the protein and mRNA levels of AXL in the MPNST cell lines. Furthermore, in two different human MPNST xenograft models, the human sAXL could be detected in the mouse plasma. Its level was proportionate to the size of the xenograft tumors, while no human sAXL was detect prior to the formation of the tumors. Treatment with a newly developed photodynamic therapy, prevented further tumor growth and resulted in drastically reduced the levels of sAXL compared to that of the control group. Finally, the level of sAXL was significantly increased in patients with plexiform tumors compared to patients with only dermal neurofibromas, further supporting the role of sAXL as a marker for NF1 related tumor burden.

  8. Soluble AXL: a possible circulating biomarker for neurofibromatosis type 1 related tumor burden.

    Directory of Open Access Journals (Sweden)

    Gunnar Johansson

    Full Text Available Neurofibromatosis type 1 (NF1 is the most common tumor predisposition disorder affecting 1/3500 worldwide. Patients are at risk of developing benign (neurofibromas and malignant peripheral nerve sheath tumors (MPNST. The AXL receptor tyrosine kinase has been implicated in several kinds of cancers, but so far no studies have investigated the role of AXL in NF1 related tumorigenesis. Recently, the soluble fraction from the extracellular domain of AXL (sAXL has been found in human plasma, and its level was correlated to poor prognosis in patients with renal cancer. Compared to normal human Schwann cells, a significantly high expression level of AXL was found in three of the four MPNST cell lines and two of the three primary MPNST tissues. Similarly, the level of sAXL in conditioned media corresponded to the protein and mRNA levels of AXL in the MPNST cell lines. Furthermore, in two different human MPNST xenograft models, the human sAXL could be detected in the mouse plasma. Its level was proportionate to the size of the xenograft tumors, while no human sAXL was detect prior to the formation of the tumors. Treatment with a newly developed photodynamic therapy, prevented further tumor growth and resulted in drastically reduced the levels of sAXL compared to that of the control group. Finally, the level of sAXL was significantly increased in patients with plexiform tumors compared to patients with only dermal neurofibromas, further supporting the role of sAXL as a marker for NF1 related tumor burden.

  9. Design and Research on Heavy-Haul Railway Turnout for 75 kg/m Rail with 30 t Axle Load Used in Central and Southern Shanxi Railway%山西中南部铁路30 t轴重75 kg/m钢轨重载道岔设计研究

    Institute of Scientific and Technical Information of China (English)

    张东风

    2014-01-01

    30t轴重重载运输是货物运输的主要发展方向之一。结合山西中南部铁路的建设,前期研究开发了30t轴重60kg/m钢轨12号、18号重载道岔,经在既有线上道试验,总体使用效果良好。但根据目前的相关技术标准,30t轴重重载线路应使用75kg/m钢轨,为此有必要研究开发75kg/m钢轨重载道岔。简要介绍75kg/m钢轨12号、18号重载道岔的研究设计,包括平面线型及结构设计,通过增大导曲线半径、尖轨加宽技术,设置轨撑、采用镶嵌式合金钢组合辙叉和高锰钢组合辙叉(爆炸硬化)等优化道岔结构设计,经动力学仿真分析研究表明:75kg/m钢轨重载道岔的结构部件位移及加速度均低于标准限值,并且能够满足行车安全性要求。%Heavy-haul railway transportation with 30 t axle load is one of the main development directions for goods transportation. In the early days, combining with the construction of Central and Southern Shanxi Railway, we had researched and developed the heavy-haul railway turnout No. 12 and No. 18 for 60 kg/m rail with 30 t axle load;and by means of field test on existing railway lines it could be seen that the overall application effect had been good. But according to the current technical standards, the heavy-haul railway of 30t axle load should be with 75 kg/m steel rail. So it is necessary to research and develop heavy-haul railway turnout for 75 kg/m rail. In this study, the research and design of the heavy-haul railway turnout No. 12 and No. 18 for 75 kg/m rail were introduced, including the horizontal geometric shape and structure design. Meanwhile, some technical measures were employed to optimize the structure design of this turnout, such as increasing the radius of derived curve, widening the switch rail, installing the rail brace, using inlaid alloy steel composite frog, as well as using high manganese steel frog ( explosion hardening) , and so on. The result of analysis and research of

  10. Impact of surface type, wheelchair weight, and axle position on wheelchair propulsion by novice older adults.

    Science.gov (United States)

    Cowan, Rachel E; Nash, Mark S; Collinger, Jennifer L; Koontz, Alicia M; Boninger, Michael L

    2009-07-01

    To examine the impact of surface type, wheelchair weight, and rear axle position on older adult propulsion biomechanics. Crossover trial. Biomechanics laboratory. Convenience sample of 53 ambulatory older adults with minimal wheelchair experience (65-87y); men, n=20; women, n=33. Participants propelled 4 different wheelchair configurations over 4 surfaces: tile, low carpet, high carpet, and an 8% grade ramp (surface, chair order randomized). Chair configurations included (1) unweighted chair with an anterior axle position, (2) 9.05 kg weighted chair with an anterior axle position, (3) unweighted chair with a posterior axle position (Delta0.08 m), and (4) 9.05 kg weighted chair with a posterior axle position (Delta0.08 m). Weight was added to a titanium folding chair, simulating the weight difference between very light and depot wheelchairs. Instrumented wheels measured propulsion kinetics. Average self-selected velocity, push frequency, stroke length, peak resultant and tangential force. Velocity decreased as surface rolling resistance or chair weight increased. Peak resultant and tangential forces increased as chair weight increased, as surface resistance increased, and with a posterior axle position. The effect of a posterior axle position was greater on high carpet and the ramp. The effect of weight was constant, but was more easily observed on high carpet and ramp. The effects of axle position and weight were independent of one another. Increased surface resistance decreases self-selected velocity and increases peak forces. Increased weight decreases self-selected velocity and increases forces. Anterior axle positions decrease forces, more so on high carpet. The effects of weight and axle position are independent. The greatest reductions in peak forces occur in lighter chairs with anterior axle positions.

  11. 49 CFR 215.105 - Defective axle.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Suspension System § 215.105 Defective axle. A railroad may not place or continue in service a car, if— (a) An axle on the car has a crack or is broken; (b) An axle on the car has a gouge in the surface that is— (1)...

  12. High Temperature Radio Frequency Loads

    CERN Document Server

    Federmann, S; Grudiev, A; Montesinos, E; Syratchev, I

    2011-01-01

    In the context of energy saving and recovery requirements the design of reliable and robust RF power loads which permit a high outlet temperature and high pressure of the cooling water is desirable. Cooling water arriving at the outlet withmore than 150 ◦C and high pressure has a higher value than water with 50 ◦C under low pressure. Conventional RF power loads containing dielectric and magnetic materials as well as sensitive ceramic windows usually do not permit going much higher than 90 ◦C. Here we present and discuss several design concepts for "metal only" RF high power loads. One concept is the application of magnetic steel corrugated waveguides near cutoff – this concept could find practical use above several GHz. Another solution are resonant structures made of steel to be installed in large waveguides for frequencies of 500 MHz or lower. Similar resonant structures above 100 MHz taking advantage of the rather high losses of normal steel may also be used in coaxial line geometries with large di...

  13. Expression of Axl and its prognostic significance in human breast cancer

    Science.gov (United States)

    Jin, Gaoyuan; Wang, Zhenzhen; Wang, Jianguang; Zhang, Like; Chen, Yanbin; Yuan, Pengfei; Liu, Dechun

    2017-01-01

    Breast cancer is the most common malignant cancer and second leading cause of cancer-related death among women, and its prevalence continues to increase. Axl overexpression has been identified in the many types of human cancer, and it has been demonstrated to participate in signaling pathways related to carcinogenesis and cancer development. In the present study, Axl expression was examined by performing immunohistochemical staining in 60 breast cancer tumors and 40 benign breast lesions (25 mammary dysplasia and 15 breast fibroadenoma). In total, 34 (56.67%) cancer tissues and 13 (32.5%) benign breast lesions were classified as exhibiting high levels of Axl expression, indicating a significant association between malignancy and high Axl expression. High Axl expression was also associated with estrogen receptor (ER) positivity (P=0.028), progesterone receptor (PR) positivity (P=0.007), and poor tumor differentiation (P=0.033). No significant associations were observed between Axl expression and age, tumor size, lymph node metastasis, tumor node metastasis staging, human epidermal growth factor receptor 2 and Ki67 antigen. The Kaplan-Meier survival analysis and Cox proportional hazard model both demonstrated that there was no statistical difference between Axl expression and breast cancer prognosis. However, it remains unclear whether the expression of Axl is correlated with the prognosis of luminal type breast cancer patients. PMID:28356938

  14. Polymer brushes under high load.

    Directory of Open Access Journals (Sweden)

    Suzanne M Balko

    Full Text Available Polymer coatings are frequently used to provide repulsive forces between surfaces in solution. After 25 years of design and study, a quantitative model to explain and predict repulsion under strong compression is still lacking. Here, we combine experiments, simulations, and theory to study polymer coatings under high loads and demonstrate a validated model for the repulsive forces, proposing that this universal behavior can be predicted from the polymer solution properties.

  15. Tolerance Limit for Trucks with Excess Load in Transport Regulation in Indonesia

    Directory of Open Access Journals (Sweden)

    Sigit Hadiwardoyo

    2012-05-01

    Full Text Available Reliability of a road is mandatory since damaged will impede the traffic. Destruction is caused by various factors; one of the most important factors is excess load. Overload may give the load of each axle of a vehicle exceeds the determined standard. This condition occurs in trucks exceeding the load limit. In designing the structure of a road based on the method of Directorate General of Highways Ministry of Public Works of the Republic of Indonesia, axle load calculated in equivalent-number, or known as equivalent axle load (EAL, of 8.16 tons of standard axle. Total equivalent-number over the service life is defined as cumulative equivalent standard axle load (CESA. Due to traffic volume exceeding the volume forecast or, in other words there is an excessive load of traffic, it will make CESA achieved faster than planned. This excessive load in Indonesia, however, has been  considered as a factor of environmental condition, so there is a need to introduce a correction factor for EAL as high as 20-25% in the process of designing flexible and rigid pavement so as to reduce early damage.

  16. Detection of early squats by axle box acceleration

    NARCIS (Netherlands)

    Molodova, M.

    2013-01-01

    This thesis discusses a new method for detection of short track irregularities, particularly squats, with axle box acceleration (ABA) measurements. A squat is a surface initiated short track defect, associated with high frequency vibrations of the wheel-rail system. High stresses in the contact

  17. Oxidative stress enhances Axl-mediated cell migration through an Akt1/Rac1-dependent mechanism.

    Science.gov (United States)

    Huang, Jhy-Shrian; Cho, Chun-Yu; Hong, Chih-Chen; Yan, Ming-De; Hsieh, Mao-Chih; Lay, Jong-Ding; Lai, Gi-Ming; Cheng, Ann-Lii; Chuang, Shuang-En

    2013-12-01

    Persistent oxidative stress is common in cancer cells because of abnormal generation of reactive oxygen species (ROS) and has been associated with malignant phenotypes, such as chemotherapy resistance and metastasis. Both overexpression of Axl and abnormal ROS elevation have been linked to cell transformation and increased cell migration. However, the relationship between Axl and ROS in malignant cell migration has not been previously evaluated. Using an in vitro human lung cancer model, we examined the redox state of lung adenocarcinoma cell lines of low metastatic (CL1-0) and high metastatic (CL1-5) potentials. Here we report that Axl activation elicits ROS accumulation through the oxidase-coupled small GTPase Rac1. We also observed that oxidative stress could activate Axl phosphorylation to synergistically enhance cell migration. Further, Axl signaling activated by H2O2 treatment results in enhancement of cell migration via a PI3K/Akt-dependent pathway. The kinase activity of Axl is required for the Axl-mediated cell migration and prolongs the half-life of phospho-Akt under oxidative stress. Finally, downregulation of Akt1, but not Akt2, by RNAi in Axl-overexpressing cells inhibits the amount of activated Rac1 and the ability to migrate induced by H2O2 treatment. Together, these results show that a novel Axl-signaling cascade induced by H2O2 treatment triggers cell migration through the PI3K/Akt1/Rac1 pathway. Elucidation of redox regulation in Axl-related malignant migration may provide new molecular insights into the mechanisms underlying tumor progression.

  18. APS high heat load monochromator

    Energy Technology Data Exchange (ETDEWEB)

    Lee, W.K.; Mills, D.

    1993-02-01

    This document contains the design specifications of the APS high heat load (HHL) monochromator and associated accessories as of February 1993. It should be noted that work is continuing on many parts of the monochromator including the mechanical design, crystal cooling designs, etc. Where appropriate, we have tried to add supporting documentation, references to published papers, and calculations from which we based our decisions. The underlying philosophy behind performance specifications of this monochromator was to fabricate a device that would be useful to as many APS users as possible, that is, the design should be as generic as possible. In other words, we believe that this design will be capable of operating on both bending magnet and ID beamlines (with the appropriate changes to the cooling and crystals) with both flat and inclined crystal geometries and with a variety of coolants. It was strongly felt that this monochromator should have good energy scanning capabilities over the classical energy range of about 4 to 20 keywith Si (111) crystals. For this reason, a design incorporating one rotation stage to drive both the first and second crystals was considered most promising. Separate rotary stages for the first and second crystals can sometimes provide more flexibility in their capacities to carry heavy loads (for heavily cooled first crystals or sagittal benders of second crystals), but their tuning capabilities were considered inferior to the single axis approach.

  19. Vibroacoustic Modeling and Path Control of Air-Borne Axle Whine Noise

    Directory of Open Access Journals (Sweden)

    Dong Guo

    2014-08-01

    Full Text Available The axle whine noise will eventually affect the vehicle noise performance. In this study, a systematic modeling approach is developed to analyze the axle whine problem by considering the hypoid gear mesh from the tooth contact process as well as the system dynamics effect with gear design parameters and shaft-bearing-housing system taken into account. Moreover, the tuning of the dominant air-borne path is modeled analytically by using the sound transmission loss idea. First, gear tooth load distribution results are obtained in a 3-dimensional loaded tooth contact analysis program. Then mesh parameters are synthesized and applied to a linear multibody gear dynamic model to obtain dynamic mesh and bearing responses. The bearing responses are used as the excitation force to a housing finite element model. Finally, the vibroacoustic analysis of the axle is performed using the boundary element method; sound pressure responses in the axle surface are then simulated. Transmission losses of different panel partitions are included in the final stage to guide the tuning of air-borne paths to reduce the radiated axle whine noise. The proposed approach gives a more in-depth understanding of the axle whine generation and therefore can further facilitate the system design and trouble-shooting.

  20. AXL mediates resistance to cetuximab therapy.

    Science.gov (United States)

    Brand, Toni M; Iida, Mari; Stein, Andrew P; Corrigan, Kelsey L; Braverman, Cara M; Luthar, Neha; Toulany, Mahmoud; Gill, Parkash S; Salgia, Ravi; Kimple, Randall J; Wheeler, Deric L

    2014-09-15

    The EGFR antibody cetuximab is used to treat numerous cancers, but intrinsic and acquired resistance to this agent is a common clinical outcome. In this study, we show that overexpression of the oncogenic receptor tyrosine kinase AXL is sufficient to mediate acquired resistance to cetuximab in models of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC), where AXL was overexpressed, activated, and tightly associated with EGFR expression in cells resistant to cetuximab (Ctx(R) cells). Using RNAi methods and novel AXL-targeting agents, we found that AXL activation stimulated cell proliferation, EGFR activation, and MAPK signaling in Ctx(R) cells. Notably, EGFR directly regulated the expression of AXL mRNA through MAPK signaling and the transcription factor c-Jun in Ctx(R) cells, creating a positive feedback loop that maintained EGFR activation by AXL. Cetuximab-sensitive parental cells were rendered resistant to cetuximab by stable overexpression of AXL or stimulation with EGFR ligands, the latter of which increased AXL activity and association with the EGFR. In tumor xenograft models, the development of resistance following prolonged treatment with cetuximab was associated with AXL hyperactivation and EGFR association. Furthermore, in an examination of patient-derived xenografts established from surgically resected HNSCCs, AXL was overexpressed and activated in tumors that displayed intrinsic resistance to cetuximab. Collectively, our results identify AXL as a key mediator of cetuximab resistance, providing a rationale for clinical evaluation of AXL-targeting drugs to treat cetuximab-resistant cancers. Cancer Res; 74(18); 5152-64. ©2014 AACR. ©2014 American Association for Cancer Research.

  1. TE_01 High Power Disk Loaded Guide Load

    Energy Technology Data Exchange (ETDEWEB)

    Farkas, Z.D.; /SLAC

    2005-06-01

    A method to design a matching section from a smooth guide to a disk-loaded guide, using a variation of broadband matching, [1, 2] is described. Using this method, we show how to design high power loads, attenuators and filters. The load consists of a disk-loaded coaxial guide operating in the TE{sub 01}-mode. We use this mode because it has no electric field terminating on a conductor, has no axial currents, and has no current at the cylinder-disk interface. A high power load design that has -35 dB reflection and a 200 MHz, -20 dB bandwidth, is presented. It is expected that it will carry the 600 MW output peak power of the pulse compression network. We use coaxial geometry and stainless steel material to increase the attenuation per cell.

  2. High voltage load resistor array

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, Monty Ray [Smithfield, VA

    2005-01-18

    A high voltage resistor comprising an array of a plurality of parallel electrically connected resistor elements each containing a resistive solution, attached at each end thereof to an end plate, and about the circumference of each of the end plates, a corona reduction ring. Each of the resistor elements comprises an insulating tube having an electrode inserted into each end thereof and held in position by one or more hose clamps about the outer periphery of the insulating tube. According to a preferred embodiment, the electrode is fabricated from stainless steel and has a mushroom shape at one end, that inserted into the tube, and a flat end for engagement with the end plates that provides connection of the resistor array and with a load.

  3. IDEAL BRAKE FORCE DISTRIBUTION BETWEEN THE AXLES OF THE TWO-AXLE VEHICLE SERVICE BRAKE APPLICATIONS

    Directory of Open Access Journals (Sweden)

    M. Podryhalo

    2015-07-01

    Full Text Available The obtained analytical expressions allow us to evaluate the stability of two-axle vehicles at various slowdowns. An analytical expression for calculating the ideal according to condition stability ensuring of a two-axle vehicle at service brake applications of brake force distribution allows to offer automatic control devices for brake force adjucement. With decellerationg growth of the two-axle vehicle at service braking the braking force acting on the front axle should decrease relative to the brake force on the rear axle.

  4. AXL mediates resistance to cetuximab therapy

    National Research Council Canada - National Science Library

    Brand, Toni M; Iida, Mari; Stein, Andrew P; Corrigan, Kelsey L; Braverman, Cara M; Luthar, Neha; Toulany, Mahmoud; Gill, Parkash S; Salgia, Ravi; Kimple, Randall J; Wheeler, Deric L

    2014-01-01

    .... In this study, we show that overexpression of the oncogenic receptor tyrosine kinase AXL is sufficient to mediate acquired resistance to cetuximab in models of non-small cell lung cancer (NSCLC...

  5. Investigation on features and tendencies of axle-box heating

    Directory of Open Access Journals (Sweden)

    Olegas LUNYS

    2015-03-01

    Full Text Available Breakdown of rolling stock axle-boxes if not detected in due time may cause a rail accident or disaster. At present, a lot of advanced technologies, modern equipment and devices, which “recognizes” faulty axle-boxes when the train is in motion, have been implemented. However, the timely identification of breakdown of rolling stock axle-boxes still is an acute problem, the initial stage of damage emergence being especially problematic. Presently, rolling stock axle-box breakdown is determined according to the higher than permissible temperature of the axle-box body. The article provides statistical data of dangerously heated axle-boxes, determined train delay durations, the number of delayed trains by danger level, and dependence of damage on the season. After systematization of data on axle-box damage and heating temperatures of broken axle-boxes, heating tendencies of axle-boxes of freight wagons are described. Finally, basic conclusions are given.

  6. Comparative Evaluation of Tractor Trolley Axle by Using Finite Element Analysis Approach

    Directory of Open Access Journals (Sweden)

    Sanjay Aloni

    2012-04-01

    Full Text Available Tractor trolley or trailers are very popular and cheaper mode of goods transport in rural as well as urban area. But these trailers are manufactured in small scale to moderate scale industry. Especially in the small- and middle-scale agricultural machinery industry, insufficient use of new technology and new design features can cause problems such as breakdowns and failures during field operations. In Present work finite element analysis approach is used to modify existing rear axle of tractor trolley. Fatigue failure of the rear axle finite element model was predicted after the dynamic load was imposed on it. For analysis, a 6.0 ton 2 wheeler tractor trolley i.e. semitrailer manufactured by Awachat Industries Ltd., Wardha is selected. The finite element analysis of existing rear axle of tractor trolley revealed the stresses distribution on rear axle. So, an effort is made to modify the design of existing rear axle along with change of material so that advantage of weight reduction along with safe stress can be obtained.

  7. rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.

    Science.gov (United States)

    Mark, M R; Scadden, D T; Wang, Z; Gu, Q; Goddard, A; Godowski, P J

    1994-04-08

    We have isolated cDNA clones that encode the human and murine forms of a novel receptor-type tyrosine kinase termed Rse. Sequence analysis indicates that human Rse contains 890 amino acids, with an extracellular region composed of two immunoglobulin-like domains followed by two fibronectin type III domains. Murine Rse contains 880 amino acids and shares 90% amino acid identity with its human counterpart. Rse is structurally similar to the receptor-type tyrosine kinase Axl/Ufo, and the two proteins have 35 and 63% sequence identity in their extracellular and intracellular domains, respectively. To study the synthesis and activation of this putative receptor-type tyrosine kinase, we constructed a version of Rse (termed gD-Rse, where gD represents glycoprotein D) that contains an NH2-terminal epitope tag. NIH3T3 cells were engineered to express gD-Rse, which could be detected at the cell surface by fluorescence-activated cell sorting. Moreover, gD-Rse was rapidly phosphorylated on tyrosine residues upon incubation of the cells with an antibody directed against the epitope tag, suggesting that rse encodes an active tyrosine kinase. In the human tissues we examined, the highest level of expression of rse mRNA was observed in the brain; rse mRNA was also detected in the premegakaryocytopoietic cell lines CMK11-5 and Dami. The gene for rse was localized to human chromosome 15.

  8. Rotation of artificial rotor axles in rotary molecular motors.

    Science.gov (United States)

    Baba, Mihori; Iwamoto, Kousuke; Iino, Ryota; Ueno, Hiroshi; Hara, Mayu; Nakanishi, Atsuko; Kishikawa, Jun-Ichi; Noji, Hiroyuki; Yokoyama, Ken

    2016-10-04

    F1- and V1-ATPase are rotary molecular motors that convert chemical energy released upon ATP hydrolysis into torque to rotate a central rotor axle against the surrounding catalytic stator cylinder with high efficiency. How conformational change occurring in the stator is coupled to the rotary motion of the axle is the key unknown in the mechanism of rotary motors. Here, we generated chimeric motor proteins by inserting an exogenous rod protein, FliJ, into the stator ring of F1 or of V1 and tested the rotation properties of these chimeric motors. Both motors showed unidirectional and continuous rotation, despite no obvious homology in amino acid sequence between FliJ and the intrinsic rotor subunit of F1 or V1 These results showed that any residue-specific interactions between the stator and rotor are not a prerequisite for unidirectional rotation of both F1 and V1 The torque of chimeric motors estimated from viscous friction of the rotation probe against medium revealed that whereas the F1-FliJ chimera generates only 10% of WT F1, the V1-FliJ chimera generates torque comparable to that of V1 with the native axle protein that is structurally more similar to FliJ than the native rotor of F1 This suggests that the gross structural mismatch hinders smooth rotation of FliJ accompanied with the stator ring of F1.

  9. The Receptor Tyrosine Kinase AXL in Cancer Progression

    Directory of Open Access Journals (Sweden)

    Erinn B. Rankin

    2016-11-01

    Full Text Available The AXL receptor tyrosine kinase (AXL has emerged as a promising therapeutic target for cancer therapy. Recent studies have revealed a central role of AXL signaling in tumor proliferation, survival, stem cell phenotype, metastasis, and resistance to cancer therapy. Moreover, AXL is expressed within cellular components of the tumor microenvironment where AXL signaling contributes to the immunosuppressive and protumorigenic phenotypes. A variety of AXL inhibitors have been developed and are efficacious in preclinical studies. These agents offer new opportunities for therapeutic intervention in the prevention and treatment of advanced disease. Here we review the literature that has illuminated the cellular and molecular mechanisms by which AXL signaling promotes tumor progression and we will discuss the therapeutic potential of AXL inhibition for cancer therapy.

  10. Three-Dimensional Dynamic Analyses of Track-Embankment-Ground System Subjected to High Speed Train Loads

    Directory of Open Access Journals (Sweden)

    Qiang Fu

    2014-01-01

    Full Text Available A three-dimensional finite element model was developed to investigate dynamic response of track-embankment-ground system subjected to moving loads caused by high speed trains. The track-embankment-ground systems such as the sleepers, the ballast, the embankment, and the ground are represented by 8-noded solid elements. The infinite elements are used to represent the infinite boundary condition to absorb vibration waves induced by the passing of train load at the boundary. The loads were applied on the rails directly to simulate the real moving loads of trains. The effects of train speed on dynamic response of the system are considered. The effect of material parameters, especially the modulus changes of ballast and embankment, is taken into account to demonstrate the effectiveness of strengthening the ballast, embankment, and ground for mitigating system vibration in detail. The numerical results show that the model is reliable for predicting the amplitude of vibrations produced in the track-embankment-ground system by high-speed trains. Stiffening of fill under the embankment can reduce the vibration level, on the other hand, it can be realized by installing a concrete slab under the embankment. The influence of axle load on the vibration of the system is obviously lower than that of train speed.

  11. Three-Dimensional Dynamic Analyses of Track-Embankment-Ground System Subjected to High Speed Train Loads

    Science.gov (United States)

    2014-01-01

    A three-dimensional finite element model was developed to investigate dynamic response of track-embankment-ground system subjected to moving loads caused by high speed trains. The track-embankment-ground systems such as the sleepers, the ballast, the embankment, and the ground are represented by 8-noded solid elements. The infinite elements are used to represent the infinite boundary condition to absorb vibration waves induced by the passing of train load at the boundary. The loads were applied on the rails directly to simulate the real moving loads of trains. The effects of train speed on dynamic response of the system are considered. The effect of material parameters, especially the modulus changes of ballast and embankment, is taken into account to demonstrate the effectiveness of strengthening the ballast, embankment, and ground for mitigating system vibration in detail. The numerical results show that the model is reliable for predicting the amplitude of vibrations produced in the track-embankment-ground system by high-speed trains. Stiffening of fill under the embankment can reduce the vibration level, on the other hand, it can be realized by installing a concrete slab under the embankment. The influence of axle load on the vibration of the system is obviously lower than that of train speed. PMID:24723838

  12. Influence of axle-wheel interface on ultrasonic testing of fatigue cracks in wheelset.

    Science.gov (United States)

    Makino, Kazunari; Biwa, Shiro

    2013-01-01

    For the ultrasonic testing at the wheel seat of railway axles, quantitative investigation of the reflection and transmission phenomena at the axle-wheel interface is important. This paper describes the influence of the axle-wheel interface on the ultrasonic testing of a fatigue crack in a wheelset by applying the spring interface model. The normal and tangential stiffnesses were identified experimentally for an as-manufactured wheelset at the normal incidence, and the reflection coefficient for the shear-wave oblique incidence was calculated. A parametric study was performed to clarify the influence of these interfacial stiffnesses on the incident-angle dependence of the reflection coefficient. The calculated reflection coefficient at the incident angle of 45° qualitatively explained the relative echo-height decrease due to the presence of a wheel observed experimentally for a wheelset in fatigue loading by rotating bending. The quantitative difference between the experimental and calculated results was considered to be due to the reduction of the effective interference of shrink fit by the wear at the axle-wheel interface during the fatigue loading as well as by the applied bending moment. For the estimated relative echo-height decrease to agree with the experimental results, the interfacial stiffnesses were found to be smaller than the values identified for the as-manufactured wheelset by a factor of 0.5-0.7.

  13. Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

    Science.gov (United States)

    Müller, Judith; Krijgsman, Oscar; Tsoi, Jennifer; Robert, Lidia; Hugo, Willy; Song, Chunying; Kong, Xiangju; Possik, Patricia A.; Cornelissen-Steijger, Paulien D.M.; Foppen, Marnix H. Geukes; Kemper, Kristel; Goding, Colin R.; McDermott, Ultan; Blank, Christian; Haanen, John; Graeber, Thomas G.; Ribas, Antoni; Lo, Roger S.; Peeper, Daniel S.

    2015-01-01

    Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we show that the lack of MITF is associated with more severe resistance to a range of inhibitors, while its presence is required for robust drug responses. Both in primary and acquired resistance, MITF levels inversely correlate with the expression of several activated receptor tyrosine kinases, most frequently AXL. The MITF-low/AXL-high/drug-resistance phenotype is common among mutant BRAF and NRAS melanoma cell lines. The dichotomous behaviour of MITF in drug response is corroborated in vemurafenib-resistant biopsies, including MITF-high and -low clones in a relapsed patient. Furthermore, drug cocktails containing AXL inhibitor enhance melanoma cell elimination by BRAF or ERK inhibition. Our results demonstrate that a low MITF/AXL ratio predicts early resistance to multiple targeted drugs, and warrant clinical validation of AXL inhibitors to combat resistance of BRAF and NRAS mutant MITF-low melanomas. PMID:25502142

  14. EVALUATION OF DYNAMIC INDICATORS OF SIX-AXLE LOCOMOTIVE

    Directory of Open Access Journals (Sweden)

    S. V. Myamlin

    2015-04-01

    Full Text Available Purpose. The paper is devoted to dynamic characteristics evaluation of the locomotive with prospective design and determination the feasibility of its use on the Ukrainian railways. Methodology. The methods of mathematical and computer modeling of the dynamics of railway vehicles, as well as methods for the numerical integration of systems of ordinary nonlinear differential equations were used to solve the problem. Findings. The calculated diagram of a locomotive on three-axle bogies was built to solve the problem, and it is a system of rigid bodies connected by various elements of rheology. The mathematical model of the locomotive movement, allowing studying its spatial vibrations at driving on straight and curved sections of the track with random irregularities in plan and profile was developed with use of this calculated diagram. At compiling the mathematical model took into account both geometric (nonlinearity profile of the wheel roll surface and physical nonlinearity of the system (the work forces of dry friction, nonlinearity characteristics of interaction forces between wheels and rails. The multivariate calculations, which allowed assessing the dynamic qualities of the locomotive at its movement along straight and curved sections of the track, were realized with the use of computer modeling. The smoothness movement indicators of the locomotive in horizontal and vertical planes, frame strength, coefficients of vertical dynamics in the first and second stages of the suspension, the load factor of resistance against the derailment of the wheel from the rail were determined at the period of research. In addition, a comparison of the obtained results with similar characteristics is widely used on the Ukrainian railways in six-axle locomotive TE 116. The influence of speed and technical state of the track on the locomotive traffic safety was determined.Originality. A mathematical model of the spatial movement of a six-axle locomotive with

  15. Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancer.

    Science.gov (United States)

    Avilla, Elvira; Guarino, Valentina; Visciano, Carla; Liotti, Federica; Svelto, Maria; Krishnamoorthy, Gnanaprakasam; Franco, Renato; Melillo, Rosa Marina

    2011-03-01

    Thyroid cancer is the most common endocrine cancer, but its key oncogenic drivers remain undefined. In this study we identified the TYRO3 and AXL receptor tyrosine kinases as transcriptional targets of the chemokine CXCL12/SDF-1 in CXCR4-expressing thyroid cancer cells. Both receptors were constitutively expressed in thyroid cancer cell lines but not normal thyroid cells. AXL displayed high levels of tyrosine phosphorylation in most cancer cell lines due to constitutive expression of its ligand GAS6. In human thyroid carcinoma specimens, but not in normal thyroid tissues, AXL and GAS6 were often coexpressed. In cell lines expressing both receptors and ligand, blocking each receptor or ligand dramatically affected cell viability and decreased resistance to apoptotic stimuli. Stimulation of GAS6-negative cancer cells with GAS6 increased their proliferation and survival. Similarly, siRNA-mediated silencing of AXL inhibited cancer cell viability, invasiveness, and growth of tumor xenografts in nude mice. Our findings suggest that a TYRO3/AXL-GAS6 autocrine circuit sustains the malignant features of thyroid cancer cells and that targeting the circuit could offer a novel therapeutic approach in this cancer. ©2011 AACR.

  16. Data on clinical characteristics of a heart failure patients’ cohort with reduced ejection fraction and analysis of the circulating values of five different heart failure biomarkers; high sensitivity troponin T, galectin-3, C-terminal propeptide of type I procollagen, soluble AXL and BNP

    Directory of Open Access Journals (Sweden)

    M. Batlle

    2016-12-01

    Full Text Available In this article, the full description of a heart failure with reduced ejection fraction (HF_REF cohort of 192 patients is provided. Tables with the baseline demographic, prior history, ECG parameters, echocardiographic parameters, laboratory values and pharmacological treatment of these patients are included. Also, the quartile values of the analyzed circulating biomarkers: high sensitivity Troponin T (hs-TnT, galectin-3 (Gal-3, C-terminal propeptide of type I procollagen (CICP, soluble AXL (sAXL and Brain Natriuretic Peptide (BNP are given. The main demographic and clinical features of the patients’ subgroups that have hs-TnT, Gal-3, CICP or BNP above the third quartile are described. Tables with Pearson correlation analysis of the HF_REF patients’ biomarker levels are included. And Pearson correlation analysis of the HF_REF patients’ hs-TnT, Gal-3, CICP levels with patients’ biochemical parameters, blood count and inflammation parameters are also described. These data are related to the research articles (AXL receptor tyrosine kinase is increased in patients with heart failure (M. Batlle, P. Recarte-Pelz, E. Roig, M.A. Castel, M. Cardona, M. Farrero, et al., 2014 [1] and Use of serum levels of high sensitivity troponin T, galectin-3 and C-terminal propeptide of type I procollagen at long term follow-up in Heart Failure patients with reduced ejection fraction: comparison with soluble AXL and BNP (M. Batlle, B. Campos, M. Farrero, M. Cardona, B. González, M.A. Castel, et al., 2016 [2].

  17. 驱动桥桥壳建模及模型网格化处理%Modeling the Drive axle housing and Meshing the model

    Institute of Scientific and Technical Information of China (English)

    肖焱曦; 赵冰; 史培龙; 张建; 常海雷

    2012-01-01

    Driving axle shell is one of the main parts on cars.It is not only the load bearing part,the transmising force and torque part but also is the main reducer,differential and wheel transmission device shell.So the quality of driving axle shell greatly affect the safe use of vehicles. Along with the economical development and the increasing vehicle possession,vehicles are developing to high-speed,continuous lightweight,low energy consumption and high performance.This requires that axle housing not only has enough intensity and rigidity,also requires mass has been reduced to structure and the vibration characteristic must be analysed.This paper mainly research on how to use the Hypermesh meshing the model which is modeled by pro-E after simplifying the drive axle housing,and check the mesher and modify the mesher the meaning of this paper is to provide a foundation model to finite element analysis of drive axle housing.%驱动桥壳是汽车上的主要零件之一,桥壳不仅是承载件还是传力件,同时又是主减速器、差速器及车轮传动装置的外壳。故驱动桥壳的质量极大影响了车辆的安全使用。随着经济发展,车辆保有量的日益增长,车辆不断向高速、轻量、低能耗和高性能发展。这要求桥壳不仅有足够的强度和刚度,还要求减轻质量以及必须对结构的振动特性分析。本文主要研究在对驱动桥壳简化及通过PROE建模后,如何在Hypermesh把模型网格化及对网格的修改和检查,本文的意义在于对驱动桥壳的有限元分析提供一个基础模型。

  18. Rational Design for Rotaxane Synthesis through Intramolecular Slippage: Control of Activation Energy by Rigid Axle Length.

    Science.gov (United States)

    Masai, Hiroshi; Terao, Jun; Fujihara, Tetsuaki; Tsuji, Yasushi

    2016-05-01

    We describe a new concept for rotaxane synthesis through intramolecular slippage using π-conjugated molecules as rigid axles linked with organic soluble and flexible permethylated α-cyclodextrins (PM α-CDs) as macrocycles. Through hydrophilic-hydrophobic interactions and flipping of PM α-CDs, successful quantitative conversion into rotaxanes was achieved without covalent bond formation. The rotaxanes had high activation barrier for their de-threading, so that they were kinetically isolated and derivatized even under conditions unfavorable for maintaining the rotaxane structures. (1) H NMR spectroscopy experiments clearly revealed that the restricted motion of the linked macrocycle with the rigid axle made it possible to control the kinetic stability by adjusting the length of the rigid axle in the precursor structure rather than the steric bulkiness of the stopper unit.

  19. Effect of Mn on hardenability of 25CrMo axle steel by an improved end-quench test

    Directory of Open Access Journals (Sweden)

    Zhang Yutuo

    2012-11-01

    Full Text Available With the sixth large-scale railway speed-up, the quality of the axles is essential to the safety of the locomotive. According to the high-speed axle technical standard for the control of alloy elements in axle steel, optimization experiments of 25CrMo steel composition were performed by vacuum inductive melting. In order to study the hardenability of high-speed rail axles, an improved end-quench test was put forward. The advantage is that it enables the heat to transfer along the axial direction, thus avoiding edge effects. The hardenability of 25CrMo axle steels with Mn content of 0.60wt.% and 0.80wt.% was investigated mainly by means of optical microscopy and hardness tests. The experimental results indicate that the Mn has a pronounced effect on the hardenability of the steel. With an increase in Mn content from 0.60wt.% and 0.80wt.%, the hardenability of 25CrMo axle steel increases and the hard microstructure is maintained at an increasing distance from the quenched end. From the surface of the water quenched end to the center of the sample, the microstructure is martensite, martensite with bainite, and bainite.

  20. On the vertical interaction between a three-axle bogie and track

    Directory of Open Access Journals (Sweden)

    Mazilu Traian

    2017-01-01

    Full Text Available In this paper, the ‘moving wheel’ model is used aiming to analysis new aspects of the interaction between three-axle bogie and track due to the harmonic roughness of the rail. The three-axle bogie of a locomotive is considered and its model is reduced to three loaded wheels running along a rail supported on a continuous elastic foundation. The track model consists of a Euler-Bernoulli beam resting on elastic foundation including two elastic layers (Winkler model representing the rail pad and ballast and one inertial layer for sleepers. The rail deflection due to the moving dead loads of the wheels is calculated and the frequency response functions of the wheels, rail in the contact points and contact forces are analysed, including the three resonance frequencies.

  1. Hepatitis C Virus Driven AXL Expression Suppresses the Hepatic Type I Interferon Response.

    Directory of Open Access Journals (Sweden)

    Scott A Read

    Full Text Available Treatment of chronic hepatitis C virus (HCV infection is evolving rapidly with the development of novel direct acting antivirals (DAAs, however viral clearance remains intimately linked to the hepatic innate immune system. Patients demonstrating a high baseline activation of interferon stimulated genes (ISGs, termed interferon refractoriness, are less likely to mount a strong antiviral response and achieve viral clearance when placed on treatment. As a result, suppressor of cytokine signalling (SOCS 3 and other regulators of the IFN response have been identified as key candidates for the IFN refractory phenotype due to their regulatory role on the IFN response. AXL is a receptor tyrosine kinase that has been identified as a key regulator of interferon (IFN signalling in myeloid cells of the immune system, but has not been examined in the context of chronic HCV infection. Here, we show that AXL is up-regulated following HCV infection, both in vitro and in vivo and is likely induced by type I/III IFNs and inflammatory signalling pathways. AXL inhibited type IFNα mediated ISG expression resulting in a decrease in its antiviral efficacy against HCV in vitro. Furthermore, patients possessing the favourable IFNL3 rs12979860 genotype associated with treatment response, showed lower AXL expression in the liver and a stronger induction of AXL in the blood, following their first dose of IFN. Together, these data suggest that elevated AXL expression in the liver may mediate an IFN-refractory phenotype characteristic of patients possessing the unfavourable rs12979860 genotype, which is associated with lower rates of viral clearance.

  2. Development of a Test Machine for IVECO Drive Axle

    Institute of Scientific and Technical Information of China (English)

    WANG Liang-mo; WANG He-fu; CHEN Jin-rong; LING Zhi-liang; CAO Yu-hua

    2007-01-01

    To improve the automation level of the vehicle drive axle test and better simulate a vehicle′s actual operation, an advanced test machine has been developed. The load system of the machine consists of hand brakes and electric cylinders. It is simple-structured and low-cost. The major motor of the machine is controlled by a transducer and its speed can be adjusted easily. In addition, the programmed machine can automatically test such parameters as the grinding condition, the differential speed, the noise level, etc. It can also adjust the test procedures according to different requirements. Detailed discussion of the structure and mechanism of the test machine is given in this paper.

  3. High power evaluation of X-band high power loads

    CERN Document Server

    Matsumoto, Shuji; Syratchev, Igor; Riddone, Germana; Wuensch, Walter

    2010-01-01

    Several types of X-band high power loads developed for several tens of MW range were designed, fabricated and used for high power tests at X-band facility of KEK. Some of them have been used for many years and few units showed possible deterioration of RF performance. Recently revised-design loads were made by CERN and the high power evaluation was performed at KEK. In this paper, the main requirements are recalled, together with the design features. The high power test results are analysed and presented

  4. Experimental Study on Tribological Property of Nano-Grease for High-Speed Railway Axle Box Bearings%高速铁路轴箱轴承纳米润滑脂摩擦学性能试验研究

    Institute of Scientific and Technical Information of China (English)

    尹延经; 何强; 杨立芳; 王世峰; 牛青波

    2015-01-01

    以WS2和Si3 N4纳米颗粒作为高速客车轴箱轴承润滑脂添加剂,依据完全析因试验方案,合成了高速客车轴箱轴承纳米润滑脂。采用四球摩擦磨损试验机对其抗磨减摩和抗极压性能进行了研究,使用扫描电子显微镜(SEM)分析了钢球磨斑表面形貌,运用双因素方差分析法探究了WS2-Si3 N4复合纳米颗粒对纳米润滑脂润滑性能影响。研究表明:当WS2添加量为1.5%,Si3 N4添加量为0.1%时,合成的纳米润滑脂PB 值最大,摩擦因数最低,钢球磨斑形貌平整光滑;WS2和Si3 N4纳米颗粒均可提高纳米润滑脂的润滑性能,对复合纳米润滑脂润滑性能的提高交互作用显著。%The WS2 and Si3 N4 nanoparticles are used as additives in lubricating grease of axle box bearings for high-speed passenger cars,the nano-grease of axle box bearings for high-speed passenger cars is synthesized based on full factorial experiment scheme.Its anti-wear,friction-reduction and anti-extreme pressure properties are investigated by using four ball friction and wear tester.The surface morphology of wear scar on steel balls is analyzed by using SEM, the effects of complex nano-particles of WS2 and Si3 N4 on lubricating properties of nano-grease are investigated by u-sing double factors variance analysis method.The results show that the PB value for synthetic nano -grease is maxi-mum,the friction coefficient is minimum,and the surface morphology of wear scar on steel balls is flat and smooth when adding 1.5%WS2 and 0.1%Si3 N4.The WS2 and Si3 N4 nano-particles improve lubricating properties of nano-grease,which have significantly interaction for improving lubricating properties of complex nano-grease.

  5. Failure analysis of axle shaft of a fork lift

    Directory of Open Access Journals (Sweden)

    Souvik Das

    2015-04-01

    Full Text Available An axle shaft of fork lift failed at operation within 296 h of service. The shaft transmits torque from discrepancy to wheel through planetary gear arrangement. A section of fractured axle shaft made of induction-hardened steel was analyzed to determine the root cause of the failure. Optical microscopies as well as field emission gun scanning electron microscopy (FEG-SEM along with energy dispersive spectroscopy (EDS were carried out to characterize the microstructure. Hardness profile throughout the cross-section was evaluated by micro-hardness measurements. Chemical analysis indicated that the shaft was made of 42CrMo4 steel grade as per specification. Microstructural analysis and micro-hardness profile revealed that the shaft was improperly heat treated resulting in a brittle case, where crack was found to initiate from the case in a brittle mode in contrast to ductile mode within the core. This behaviour was related to differences in microstructure, which was observed to be martensitic within the case with a micro-hardness equivalent to 735 HV, and a mixture of non-homogeneous structure of pearlite and ferrite within the core with a hardness of 210 HV. The analysis suggests that the fracture initiated from the martensitic case as brittle mode due to improper heat treatment process (high hardness. Moreover the inclusions along the hot working direction i.e. in the longitudinal axis made the component more susceptible to failure.

  6. Heavy and Overweight Vehicle Brake Testing: Five-Axle Combination Tractor-Flatbed Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Lascurain, Mary Beth [ORNL; Capps, Gary J [ORNL; Franzese, Oscar [ORNL

    2013-10-01

    The Federal Motor Carrier Safety Administration, in coordination with the Federal Highway Administration, sponsored the Heavy and Overweight Vehicle Brake Testing (HOVBT) program in order to provide information about the effect of gross vehicle weight (GVW) on braking performance. Because the Federal Motor Carrier Safety Regulations limit the number of braking system defects that may exist for a vehicle to be allowed to operate on the roadways, the examination of the effect of brake defects on brake performance for increased loads is also relevant. The HOVBT program seeks to provide relevant information to policy makers responsible for establishing load limits, beginning with providing test data for a combination tractor/trailer. This testing was conducted on a five-axle combination vehicle with tractor brakes meeting the Reduced Stopping Distance requirement rulemaking. This report provides a summary of the testing activities, the results of various analyses of the data, and recommendations for future research. Following a complete brake rebuild, instrumentation, and brake burnish, stopping tests were performed from 20 and 40 mph with various brake application pressures (15 psi, 25 psi, 35 psi, 45 psi, 55 psi, and full system pressure). These tests were conducted for various brake conditions at the following GVWs: 60,000, 80,000, 91,000, 97,000, 106,000, and 116,000 lb. The 80,000-lb GVWs included both balanced and unbalanced loads. The condition of the braking system was also varied. To introduce these defects, brakes (none, forward drive axle, or rear trailer axle) were made inoperative. In addition to the stopping tests, performance-based brake tests were conducted for the various loading and brake conditions. Analysis of the stopping test data showed the stopping distance to increase with load (as expected) and also showed that more braking force was generated by the drive axle brakes than the trailer axle brakes. The constant-pressure stopping test data

  7. AXL is an oncotarget in human colorectal cancer

    Science.gov (United States)

    Martinelli, Erika; Troiani, Teresa; Liguori, Giuseppina; Vitagliano, Donata; Napolitano, Stefania; Morgillo, Floriana; Rinaldi, Barbara; Melillo, Rosa Marina; Liotti, Federica; Nappi, Anna; Bianco, Roberto; Berrino, Liberato; Ciuffreda, Loreta Pia; Ciardiello, Davide; Iaffaioli, Vincenzo; Botti, Gerardo; Ferraiolo, Fiorella; Ciardiello, Fortunato

    2015-01-01

    AXL is a tyrosine kinase receptor activated by GAS6 and regulates cancer cell proliferation migration and angiogenesis. We studied AXL as new therapeutic target in colorectal cancer (CRC). Expression and activation of AXL and GAS6 were evaluated in a panel of human CRC cell lines. AXL gene silencing or pharmacologic inhibition with foretinib suppressed proliferation, migration and survival in CRC cells. In an orthotopic colon model of human HCT116 CRC cells overexpressing AXL, foretinib treatment caused significant inhibition of tumour growth and peritoneal metastatic spreading. AXL and GAS6 overexpression by immunohistochemistry (IHC) were found in 76,7% and 73.5%, respectively, of 223 human CRC specimens, correlating with less differentiated histological grading. GAS6 overexpression was associated with nodes involvement and tumour stage. AXL gene was found amplified by Fluorescence in situ hybridization (FISH) in 8/146 cases (5,4%) of CRC samples. Taken together, AXL inhibition could represent a novel therapeutic approach in CRC. PMID:25966280

  8. Phyllodes tumor of the breast: role of Axl and ST6GalNAcII in the development of mammary phyllodes tumors.

    Science.gov (United States)

    Ren, Dongliang; Li, Yanyan; Gong, Yanxin; Xu, Jingchao; Miao, Xiaolong; Li, Xiangnan; Liu, Chen; Jia, Li; Zhao, Yongfu

    2014-10-01

    Phyllodes tumor exhibits an aggressive growth. The expression of many biological markers has been explored to discriminate between different grades of phyllodes tumor and to predict their behavior. The purpose of this study was to evaluate the implications of Axl and ST6GalNAcII in phyllodes tumors. Real-time PCR, Western blot, and immunohistochemical were used to analyze differential expression of ST6GalNAcII and Axl in phyllodes tumor (PT) cell lines and tissue specimens. RNAi assay, ECM invasion assay, and tumorigenicity assay were used to analyze the altered expression of ST6GalNAcII gene effects on the expression of Axl and invasive ability of phyllodes tumor cells in vitro and in vivo. Compared to benign tumors, borderline and malignant ones showed a remarkable increase in mRNA levels of Axl and ST6GalNAcII gene, and it was higher in malignant tumor cells than in borderline tumor cells. When ST6GalNAcII was silenced, compared to the control, the expression level of Axl was significantly reduced in malignant tumor cell transfectants and knockdown of ST6GalNAcII gene significantly inhibited invasive activity in malignant tumor cells. The high expression of ST6GalNAcII and Axl was significantly correlated with tumor grade and distance metastasis by immunohistochemical analysis. Axl and ST6GalNAcII expression increases with increasing tumor grade in mammary phyllodes tumors. ST6GalNAc II might be participated in the glycosylation of Axl, and this Axl glycosylation may mediate the tumorigenicity, invasion, and distant metastasis of PT cells.

  9. Retrofit of Connector of Axle with High Temperature Butterfly Valve%高温蝶阀阀轴连接键结构改造

    Institute of Scientific and Technical Information of China (English)

    袁亚; 孙艳萍; 张元元

    2012-01-01

    重油催化裂化装置高温蝶阀是烟气轮机入口管线上控制高温烟气流量的重要设备,本文对高温蝶阀存在的问题进行了分析,并通过对高温蝶阀转轴与阀板的连接键进行结构改造,解决了高温蝶阀因阀板变形而导致的密封失效问题,节约了检修时间及费用.%High temperature butterfly valve of the heavy oil catalytic cracker is the important equipment that controling high temperature flue gas flow with inlet line of flue gas turbine.The problems of seal failure on high temperature butterfly valve was analyzed, and the problem was solved through retrofiting of connection key. The transformation save repairing time of expense.

  10. Dynamic analysis of rail vehicle axle

    Indian Academy of Sciences (India)

    Ferhat Dikmen; Meral Bayraktar; Rahmi Guclu

    2013-04-01

    In this paper, in order to obtain the dynamic forces on the passenger coach axle, a full rail vehicle model with 19-dof (degrees of freedom) has been considered. For a specific example, the variations of these dynamic forces with velocity of the passenger coach, suspension characteristics and way conditions have been examined. Dynamic forces found in the resonance regions at the range of 2–5 m/s (7.2–18 km/h) has been discussed. Theoretical results obtained for the dynamic forces have been successfully compared with the experimental results of German Railways (Deutsche Bahn-DB).

  11. High power s-band vacuum load

    Energy Technology Data Exchange (ETDEWEB)

    Neubauer, Michael [Muons, Inc., Batavia, IL (United States); Dudas, Alan [Muons, Inc., Batavia, IL (United States); Krasnykh, Anatoly [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-12-29

    Through a combination of experimentation and calculation the components of a novel room temperature dry load were successfully fabricated. These components included lossy ceramic cylinders of various lengths, thicknesses, and percent of silicon carbide (SiC). The cylinders were then assembled into stainless steel compression rings by differential heating of the parts and a special fixture. Post machining of this assembly provided a means for a final weld. The ring assemblies were then measured for S-parameters, individually and in pairs using a low-cost TE10 rectangular to TE01 circular waveguide adapter specially designed to be part of the final load assembly. Matched pairs of rings were measured for assembly into the final load and a sliding short designed and fabricated to assist in determining the desired short location in the final assembly. The plan for the project was for Muons, Inc. to produce prototype loads for long-term testing at SLAC. The STTR funds for SLAC were to upgrade and operate their test station to ensure that the loads would satisfy their requirements. Phase III was to be the sale to SLAC of loads that Muons, Inc. would manufacture. However, an alternate solution that involved a rebuild of the old loads, reduced SLAC budget projections, and a relaxed time for the replacement of all loads meant that in-house labor will be used to do the upgrade without the need for the loads developed in this project. Consequently, the project was terminated before the long term testing was initiated. However, SLAC can use the upgraded test stand to compare the long-term performance of the ones produced in this project with their rebuilt loads when they are available.

  12. The degradation processes in high loaded casts

    Directory of Open Access Journals (Sweden)

    E. Ďuriníková

    2010-01-01

    Full Text Available In this work are described structural changes of jet engine DV – 2 turbine blades and effect of degradation process. Turbine blades work in aggressively environs and because of that there are rate among high loaded cast stock. As an experimental material we have chose nickel superalloy ŽS6K with surface heat - resisting alitize layer. Evaluation is slant on largeness wearing over work of certain number of hour in operation. Effect working environs and overrun working temperatures is show changes measures as well as changes macrostructure of basic material blades. Evaluate is advance quantitative metallography through the medium metallographic software NIS element. Quantitative analysis evaluate thickness measures, quality control outer look and lack mixture in the seat, which is not splash, is precede by lack of near another applied protective layer. Allowance is knot on last examination in the area ratings protective heat-resisting layers and gives records for others possible ratings and experiments in this area.

  13. Numerical evaluation of tandem rotor for highly loaded transonic fan

    Institute of Scientific and Technical Information of China (English)

    ZHAO Bin; LIU Bao-jie

    2011-01-01

    Transonic tandem rotor was designed for highly loaded fan at a corrected tip speed of 381 m/s and another conventional rotor was designed as a baseline to evaluate the loading superiority of tandem rotor with three-dimensional (3-D) numerical simulation. The aft blade solidity and its impact on total loading level were studied in depth. The result indicates that tandem rotor has potential to achieve higher loading level and attain favorable aerodynamic performance in a wide range of loading coefficient 0. 55 ~ 0.68, comparing with the conventional rotor which produced a total pressure ratio of 2.0 and loading coefficient of 0. 42.

  14. Repeated Load Permanent Deformation Behavior of Mixes With and Wihtout Modified Bituments

    Directory of Open Access Journals (Sweden)

    Imran Hafeez

    2011-01-01

    Full Text Available Premature rutting in flexible pavement structure is being observed on most of the road network of Pakistan. It initiates primarily due to uncontrolled axle loading and high ambient temperatures. NHA (National Highway Authority, Pakistan has continuously been modifying aggregate gradations and penetration grade of bitumen, without any prior investigation of the mix behaviour under the prevailing axle load and environmental conditions of the country. A comprehensive laboratory investigation was carried out on six mixes ranging from finer to coarser. Specimens were subjected to cyclic loading on UTM-5P (Universal Testing Machine to study the resistance against permanent deformation of the mixes at 25, 40 and 550C. At low temperatures and stress levels, both coarse and fine graded mixes showed less accumulated strain, whereas at higher temperatures and stress levels, coarse graded mix with PMB (Polymer Modified Bitumen showed good resistance to permanent deformation.

  15. Vibration control of bridge subjected to multi-axle vehicle using multiple tuned mass friction dampers

    Science.gov (United States)

    Pisal, Alka Y.; Jangid, R. S.

    2016-06-01

    The effectiveness of tuned mass friction damper (TMFD) in reducing undesirable resonant response of the bridge subjected to multi-axle vehicular load is investigated. A Taiwan high-speed railway (THSR) bridge subjected to Japanese SKS (Salkesa) train load is considered. The bridge is idealized as a simply supported Euler-Bernoulli beam with uniform properties throughout the length of the bridge, and the train's vehicular load is modeled as a series of moving forces. Simplified model of vehicle, bridge and TMFD system has been considered to derive coupled differential equations of motion which is solved numerically using the Newmark's linear acceleration method. The critical train velocities at which the bridge undergoes resonant vibration are investigated. Response of the bridge is studied for three different arrangements of TMFD systems, namely, TMFD attached at mid-span of the bridge, multiple tuned mass friction dampers (MTMFD) system concentrated at mid-span of the bridge and MTMFD system with distributed TMFD units along the length of the bridge. The optimum parameters of each TMFD system are found out. It has been demonstrated that an optimized MTMFD system concentrated at mid-span of the bridge is more effective than an optimized TMFD at the same place with the same total mass and an optimized MTMFD system having TMFD units distributed along the length of the bridge. However, the distributed MTMFD system is more effective than an optimized TMFD system, provided that TMFD units of MTMFD system are distributed within certain limiting interval and the frequency of TMFD units is appropriately distributed.

  16. Study on control schemes of flexible steering system of a multi-axle all-wheel-steering robot

    Directory of Open Access Journals (Sweden)

    Pingxia Zhang

    2016-05-01

    Full Text Available It is well known that a multi-axle wheeled robot possesses larger load capability and also higher drive performance. However, its steering flexibility is degraded due to the large number of wheels. In order to solve this problem, in this article, we proposed three control schemes based on the center of rotation or the steering angles of both the first- and last-axle wheels. To release these control schemes, steering mode selection and also the left wheel’s steering angle in a specific axle are added approaching a practical application. Thereafter, the remaining wheels’ steering angles can be calculated with the Ackerman steering theorem. In order to verify the control effects, a five-axle all-wheel-steering wheeled robot has been developed with the Bluetooth wireless monitor system. Based on the newly designed robot, validation experiments are carried out, such as lateral movement, situ rotation, and multi-mode steering within a narrow space. The results indicate that the proposed design in this article can ensure a more flexible and faster movement within a narrow space. It shows large potential in obstacle avoidance compared with the conventional partial-wheel steering mode.

  17. FRONT AXLE OF MERCEDES AMG GT. MODELLING IN AUTODESK INVENTOR

    Directory of Open Access Journals (Sweden)

    COROLENCU Eduard – Narcis

    2017-05-01

    Full Text Available This paper analyzes the front axle of the Mercedes AMG GT model, as so as the graphical representation of the axle and of the subassemblies of suspension system and steering system, using the AutoCAD and Autodesk Inventor software. The paper include the steps for made the 3D model of the front axle in order to highlight the advantages of suspension and steering system, the function of this systems and methods for manufacturing of these. The 3D model presents a suite of complex surfaces. This type of surfaces is often designed with non-analytical means. The main commands and options used in Autodesk Inventor software were presented and explained. All the component parts of the front axle were modelled and assembled according to their functional role. Finally, the models were rendered in order to have a realistic appearance.

  18. Design Rules Discussion for Improving Multi-axle Vehicle Stability

    Institute of Scientific and Technical Information of China (English)

    ZHU Xuebin; JIANG Yingquan; GAO Feng

    2006-01-01

    A whole vehicle dynamic model is built, and the modeling method of connected hydragas spring suspension and multi-axle grouping steer system is also explained. Firstly, a kinematical analysis of suspension is implemented to achieve optimized suspension geometry parameters according to the stable requirement. Then, based on the evaluation of whole vehicle handling character with regard to various tire characters, driving configurations and super structures, the design rules are summarized to improve the stability of multi-axle vehicle.

  19. NEW TECHNOLOGY AND MACHINE TOOL FOR THE FORMING OF THE REAR AXLE SHAFT OF LIGHT TRUCK

    Institute of Scientific and Technical Information of China (English)

    Han Yingchun; Yu Duonian; Wang Xueming

    2004-01-01

    A new technology of forward extrusion and cross rolling has been developed to process the rear axle shaft sleeve of light truck with the use of tube billets. This technology is characterized by large reductions of material, energy and cost of production and has significant economical benefits. This technology is stable and reliable. The three rolls transverse rolling mill built based on this technology has novelty construction, higher production efficiency, non-vibration and noise. The research results have been extensively applied to light trucks and farm transport with load of 1 to 3 tones.

  20. FLEXIBLE 2-DOF STEERING MODEL OF MULTI-AXLE HEAVY-DUTY VEHICLE

    Institute of Scientific and Technical Information of China (English)

    Yang Bo; Wang Xuelin; Hu Yujin; Li Chenggang

    2004-01-01

    A flexible two degrees of freedom (2-DOF) steering model of multi-axle vehicle (MAV) is presented with considering the effect of frame flexibility based on the classic 2-DOF model. A method to calculate the frame flexibility is derived by using three moments equation. The steering stability of MAV is analyzed. The steering performance of MAV is also researched in frequency domain. Simulation results show that the dynamic effects of flexible model are more severe than rigid model and the flexible effect of frame will weaken the steering stability of MAV. Different disposals of steering axles lead to different steering characteristics of MAV. The in-phase steering mode improves the steering characteristics and stability at high speed. The anti-phase steering mode increases the steering mobility at low vehicle speed.

  1. Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells.

    Science.gov (United States)

    Nowakowski, Tomasz J; Pollen, Alex A; Di Lullo, Elizabeth; Sandoval-Espinosa, Carmen; Bershteyn, Marina; Kriegstein, Arnold R

    2016-05-01

    The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in fetal abnormalities and microcephaly. However, information about the underlying molecular and cellular mechanisms connecting viral infection to these defects remains limited. In this study we have examined the expression of receptors implicated in cell entry of several enveloped viruses including ZIKV across diverse cell types in the developing brain. Using single-cell RNA-seq and immunohistochemistry, we found that the candidate viral entry receptor AXL is highly expressed by human radial glial cells, astrocytes, endothelial cells, and microglia in developing human cortex and by progenitor cells in developing retina. We also show that AXL expression in radial glia is conserved in developing mouse and ferret cortex and in human stem cell-derived cerebral organoids, highlighting multiple experimental systems that could be applied to study mechanisms of ZIKV infectivity and effects on brain development.

  2. Sobrecompactación del suelo agricola parte I: influencia diferencial del peso y del número de pasadas Overcompaction of agricultural soil part I: differential influence of axle load and number of passes

    Directory of Open Access Journals (Sweden)

    Daniel Jorajuria

    2000-12-01

    out on grassland, on a typic Argiudol with a soil moisture below, but near to field capacity. The dependent experimental variable was the induced soil compaction and was related to bulk density (assessed with gamma probe, penetration resistance (measured with an electronic cone penetrometer, and remaining grassland yield, six and eight months after traffic treatments were applied. Data from two tests, with two phases of data logging were analysed, totalizing a three year period of assessment pursuit. Results did not show differences between heavy and light treatments in the shallower depth range. Nevertheless, highly significant differences were shown if the deepest range is considered. Decrease in grassland yields ranging from 7 to 25% were measured in out-of-track areas, and 52 to 76% in intrack areas. It was concluded that the number of repeated passes on the same tramlines of a light tractor, can do as much or even greater damage than the heavier tractor with fewer passes. Ten is the critical number of passes, beyond it, advantages taken from the use of a light tractor are lost.

  3. Low reflectance high power RF load

    Energy Technology Data Exchange (ETDEWEB)

    Ives, R. Lawrence; Mizuhara, Yosuke M.

    2016-02-02

    A load for traveling microwave energy has an absorptive volume defined by cylindrical body enclosed by a first end cap and a second end cap. The first end cap has an aperture for the passage of an input waveguide with a rotating part that is coupled to a reflective mirror. The inner surfaces of the absorptive volume consist of a resistive material or are coated with a coating which absorbs a fraction of incident RF energy, and the remainder of the RF energy reflects. The angle of the reflector and end caps is selected such that reflected RF energy dissipates an increasing percentage of the remaining RF energy at each reflection, and the reflected RF energy which returns to the rotating mirror is directed to the back surface of the rotating reflector, and is not coupled to the input waveguide. Additionally, the reflector may have a surface which generates a more uniform power distribution function axially and laterally, to increase the power handling capability of the RF load. The input waveguide may be corrugated for HE11 mode input energy.

  4. A New Approach for Reliability Life Prediction of Rail Vehicle Axle by Considering Vibration Measurement

    Directory of Open Access Journals (Sweden)

    Meral Bayraktar

    2014-01-01

    Full Text Available The effect of vibration on the axle has been considered. Vibration measurements at different speeds have been performed on the axle of a running rail vehicle to figure out displacement, acceleration, time, and frequency response. Based on the experimental works, equivalent stress has been used to find out life of the axles for 90% and 10% reliability. Calculated life values of the rail vehicle axle have been compared with the real life data and it is found that the life of a vehicle axle taking into account the vibration effects is in good agreement with the real life of the axle.

  5. Cementitious Stabilization of Mixed Wastes with High Salt Loadings

    Energy Technology Data Exchange (ETDEWEB)

    Spence, R.D.; Burgess, M.W.; Fedorov, V.V.; Downing, D.J.

    1999-04-01

    Salt loadings approaching 50 wt % were tolerated in cementitious waste forms that still met leach and strength criteria, addressing a Technology Deficiency of low salt loadings previously identified by the Mixed Waste Focus Area. A statistical design quantified the effect of different stabilizing ingredients and salt loading on performance at lower loadings, allowing selection of the more effective ingredients for studying the higher salt loadings. In general, the final waste form needed to consist of 25 wt % of the dry stabilizing ingredients to meet the criteria used and 25 wt % water to form a workable paste, leaving 50 wt % for waste solids. The salt loading depends on the salt content of the waste solids but could be as high as 50 wt % if all the waste solids are salt.

  6. High-Frequency Axial Fatigue Test Procedures for Spectrum Loading

    Science.gov (United States)

    2016-07-20

    REPORT NO: NAWCADPAX/TIM-2016/49 HIGH - FREQUENCY AXIAL FATIGUE TEST PROCEEDURES FOR SPECTRUM LOADING by David T. Rusk, AIR...OF THE NAVY NAVAL AIR WARFARE CENTER AIRCRAFT DIVISION PATUXENT RIVER, MARYLAND NAWCADPAX/TIM-2016/49 20 July 2016 HIGH - FREQUENCY AXIAL...Technical Information Memorandum 3. DATES COVERED 4. TITLE AND SUBTITLE High - Frequency Axial Fatigue Test Procedures for Spectrum Loading

  7. A Flexible Arrayed Eddy Current Sensor for Inspection of Hollow Axle Inner Surfaces

    Directory of Open Access Journals (Sweden)

    Zhenguo Sun

    2016-06-01

    Full Text Available A reliable and accurate inspection of the hollow axle inner surface is important for the safe operation of high-speed trains. In order to improve the reliability of the inspection, a flexible arrayed eddy current sensor for non-destructive testing of the hollow axle inner surface was designed, fabricated and characterized. The sensor, consisting of two excitation traces and 28 sensing traces, was developed by using the flexible printed circuit board (FPCB technique to conform the geometric features of the inner surfaces of the hollow axles. The main innovative aspect of the sensor was the new arrangement of excitation/sensing traces to achieve a differential configuration. Finite element model was established to analyze sensor responses and to determine the optimal excitation frequency. Experimental validations were conducted on a specimen with several artificial defects. Results from experiments and simulations were consistent with each other, with the maximum relative error less than 4%. Both results proved that the sensor was capable of detecting longitudinal and transverse defects with the depth of 0.5 mm under the optimal excitation frequency of 0.9 MHz.

  8. Overview of High Power Vacuum Dry RF Load Designs

    Energy Technology Data Exchange (ETDEWEB)

    Krasnykh, Anatoly [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-08-27

    A specific feature of RF linacs based on the pulsed traveling wave (TW) mode of operation is that only a portion of the RF energy is used for the beam acceleration. The residual RF energy has to be terminated into an RF load. Higher accelerating gradients require higher RF sources and RF loads, which can stably terminate the residual RF power. RF feeders (from the RF source though the accelerating section to the load) are vacuumed to transmit multi-megawatt high power RF. This overview will outline vacuumed RF loads only. A common method to terminate multi-MW RF power is to use circulated water (or other liquid) as an absorbing medium. A solid dielectric interface (a high quality ceramic) is required to separate vacuum and liquid RF absorber mediums. Using such RF load approaches in TW linacs is troubling because there is a fragile ceramic window barrier and a failure could become catastrophic for linac vacuum and RF systems. Traditional loads comprising of a ceramic disk have limited peak and average power handling capability and are therefore not suitable for high gradient TW linacs. This overview will focus on ''vacuum dry'' or ''all-metal'' loads that do not employ any dielectric interface between vacuum and absorber. The first prototype is an original design of RF loads for the Stanford Two-Mile Accelerator.

  9. High-Temperature, High-Load-Capacity Radial Magnetic Bearing

    Science.gov (United States)

    Provenza, Andrew; Montague, Gerald; Kascak, Albert; Palazzolo, Alan; Jansen, Ralph; Jansen, Mark; Ebihara, Ben

    2005-01-01

    A radial heteropolar magnetic bearing capable of operating at a temperature as high as 1,000 F (=540 C) has been developed. This is a prototype of bearings for use in gas turbine engines operating at temperatures and speeds much higher than can be withstood by lubricated rolling-element bearings. It is possible to increase the maximum allowable operating temperatures and speeds of rolling-element bearings by use of cooling-air systems, sophisticated lubrication systems, and rotor-vibration- damping systems that are subsystems of the lubrication systems, but such systems and subsystems are troublesome. In contrast, a properly designed radial magnetic bearing can suspend a rotor without contact, and, hence, without need for lubrication or for cooling. Moreover, a magnetic bearing eliminates the need for a separate damping system, inasmuch as a damping function is typically an integral part of the design of the control system of a magnetic bearing. The present high-temperature radial heteropolar magnetic bearing has a unique combination of four features that contribute to its suitability for the intended application: 1. The wires in its electromagnet coils are covered with an insulating material that does not undergo dielectric breakdown at high temperature and is pliable enough to enable the winding of the wires to small radii. 2. The processes used in winding and potting of the coils yields a packing factor close to 0.7 . a relatively high value that helps in maximizing the magnetic fields generated by the coils for a given supplied current. These processes also make the coils structurally robust. 3. The electromagnets are of a modular C-core design that enables replacement of components and semiautomated winding of coils. 4. The stator is mounted in such a manner as to provide stable support under radial and axial thermal expansion and under a load as large as 1,000 lb (.4.4 kN).

  10. Strong Expression of Hypoxia-Inducible Factor-1α (HIF-1α Is Associated with Axl Expression and Features of Aggressive Tumors in African Breast Cancer.

    Directory of Open Access Journals (Sweden)

    Hawa Nalwoga

    Full Text Available Inhibition of hypoxia-inducible factor (HIF and Axl receptor tyrosine kinase is being evaluated for targeted therapy in solid tumors. Both HIF-1α and Axl influence tumor growth and metastatic potential, and they have been linked to treatment failure in many cancers. However, there is a lack of reports on HIF-1α expression in African breast cancer, which has a poor prognosis, and novel treatment targets must therefore be established. Here, we aimed to evaluate HIF-1α in relation to Axl expression, angiogenesis markers, and other tumor characteristics in a series of African breast cancer.Using immunohistochemistry, we examined 261 invasive breast cancers on tissue microarrays for HIF-1α and Axl as well as several other markers, and a subset of 185 cases had information on VEGF (vascular endothelial growth factor expression, microvessel density (MVD, proliferating microvessel density (pMVD and vascular proliferation index (VPI for important comparisons.Strong HIF-1α expression was associated with increased Axl (p = 0.007, VEGF (p<0.0005, and p53 (p = 0.032 expression, as well as high tumor cell proliferation by Ki-67 (p = 0.006, and high tumor grade (p = 0.003. Tumors with strong HIF-1α expression had significantly higher MVD (p = 0.019 and higher pMVD (p = 0.027 than tumors with weak expression.High HIF-1α expression is significantly associated with Axl and VEGF expression, and with markers of poor prognosis in this series of breast cancer, suggesting HIF-1α and Axl as potential therapeutic targets in African breast cancer.

  11. Energy efficiency indicators for high electric-load buildings

    Energy Technology Data Exchange (ETDEWEB)

    Aebischer, Bernard; Balmer, Markus A.; Kinney, Satkartar; Le Strat, Pascale; Shibata, Yoshiaki; Varone, Frederic

    2003-06-01

    Energy per unit of floor area is not an adequate indicator for energy efficiency in high electric-load buildings. For two activities, restaurants and computer centres, alternative indicators for energy efficiency are discussed.

  12. MULTI-AXLE VEHICLE STABILITY BASED ON WHOLE VEHICLE MODEL

    Institute of Scientific and Technical Information of China (English)

    ZHU Xuebin; GAO Feng

    2007-01-01

    From the analysis of experiment data of the multi-axle vehicle chassis searching process, it is less accurate to predict multi-axle vehicle dynamic characteristic with simplified two-axle vehicle model. So it is important to find out a more effective modeling method in the study of multi-vehicle stability. In the development of heat transfer fluid(HTF) six-axle vehicle, a whole vehicle multi-body dynamic model is built through collaborate flowchart using Teamcenter Engineering, UG NX3 and MSC. Adams. The modeling method of connected hydragas spring suspension is validated by running test results. Based on this whole vehicle model, a kinematical analysis of suspension is implemented to achieve optimized suspension geometry parameters according to the stable requirement. Then, different handling simulations are carried out with regard to various tire characteristics, driving configurations, and equipments. According to the evaluation of whole vehicle handling characteristic, some design rules are summarized to improve the stability of multi-axle vehicle.

  13. Part-load performance of a high temperature Kalina cycle

    DEFF Research Database (Denmark)

    Modi, Anish; Andreasen, Jesper Graa; Kærn, Martin Ryhl

    2015-01-01

    bottoming cycle, and solar power plants. The high temperature cycle layouts are inherently more complex than the low temperature layouts due to the presence of a distillation-condensation subsystem, three pressure levels, and several heat exchangers. This paper presents a detailed approach to solve...... the Kalina cycle in part-load operating conditions for high temperature (a turbine inlet temperature of 500 °C) and high pressure (100 bar) applications. A central receiver concentrating solar power plant with direct vapour generation is considered as a case study where the part-load conditions are simulated...... by changing the solar heat input to the receiver. Compared with the steam Rankine cycle, the Kalina cycle has an additional degree of freedom in terms of the ammonia mass fraction which can be varied in order to maximize the part-load efficiency of the cycle. The results include the part-load curves...

  14. The Application of Phased Array Ultrasonic Techniques for Inspection of Railway Axles from Their End Face

    Science.gov (United States)

    Liaptsis, D.; Cooper, I.; Boyle, K.; Nicholson, P. I.

    2011-06-01

    As part of the development of a non destructive testing (NDT) system combining complementary inspection techniques, an inspection system based on phased array ultrasonic testing (PAUT) for detection of transverse cracking in solid railway axles is being developed. This paper presents the initial study, which includes the PAUT experimental setup and the initial results obtained after testing the system on railway axle blocks. The inspection of solid axles from their axle end face is investigated.

  15. Recommendations regarding higher axlemass limits for axles fitted with wide base tyres

    CSIR Research Space (South Africa)

    Roux, MP

    2011-01-01

    Full Text Available This paper presents the results of an investigation into possible higher axle mass limits for axles and axle units fitted with wide base tyres, i.e. tyres with nominal section widths of 385 mm, 425 mm and 445 mm, by comparing the road wear caused...

  16. Thoughts on Process Design of Ji'nan West Wheel Axle Workshop%济南西轮轴车间工艺设计思考

    Institute of Scientific and Technical Information of China (English)

    赵勇

    2012-01-01

    This paper, according to the relevant design contents of wheel axle workshop of Ji'nan West Rolling Stock Depot, investigates comprehensively the whole maintenance process and the equipment configuration of wheel axle's overhaul, from several aspects such as the function partitioning of inspection and repair depots, wheelset-input inspection , wheelset-export inspection, mechanical processing of wheel axle, HMIS system and so on. Moreover, the paper introduces emphatically the working principle, main features and the related functions about the process line which consists of the loading and unloading robot, axle transmission line, wheel transmission line, and the press-fit units. In addition, this paper summarizes the entire maintenance process in relation to the wheel axle's automation and process line's maintenance, with a view to provide reference for wheel axle repair design of other projects.%根据济南西车辆段轮轴车间设计相关内容,从轮轴检修库房工艺功能划分、轮对收入检查部分、轮对支出检查部分、车轴轮片机械加工部分、HMIS系统等几个方面入手,全面探讨轮轴大修的整个检修工艺流程和设备配置情况,并着重介绍上下料机械手、车轴输送线、车轮输送线和压装单元组成的工艺流水线的工作原理、主要特点和相关功能.总结轮轴自动化、流水线检修的整个检修工艺流程,可为其他工程轮轴检修设计提供参考依据.

  17. Automatic imitation? Imitative compatibility affects responses at high perceptual load.

    Science.gov (United States)

    Catmur, Caroline

    2016-04-01

    Imitation involves matching the visual representation of another's action onto the observer's own motor program for that action. However, there has been some debate regarding the extent to which imitation is "automatic"-that is, occurs without attention. Participants performed a perceptual load task in which images of finger movements were presented as distractors. Responses to target letter stimuli were performed via finger movements that could be imitatively compatible (requiring the same finger movement) or incompatible with the distractor movements: In this common stimulus-response compatibility manipulation, the stimulus set comprises images of the response movements, producing an imitative compatibility effect. Attention to the distractor movements was manipulated by altering perceptual load through increasing the number of nontarget letter stimuli. If imitation requires attention, then at high perceptual load, imitative compatibility should not affect response times. In contrast, imitative compatibility influenced response times at high perceptual load, demonstrating that distractor movements were processed. However, the compatibility effect was reversed, suggesting that longer response times at high perceptual load tap into an inhibitory stage of distractor movement processing. A follow-up experiment manipulating temporal delay between targets and distractor movements supported this explanation. Further experiments confirmed that nonmovement distractor stimuli in the same configuration produced standard perceptual load effects and that results were not solely due to effector compatibility. These data suggest that imitation can occur without attention. (PsycINFO Database Record

  18. Influence of load by high power on the optical coupler

    Science.gov (United States)

    Bednarek, Lukas; Poboril, Radek; Vanderka, Ales; Hajek, Lukas; Nedoma, Jan; Vasinek, Vladimir

    2016-12-01

    Nowadays, aging of the optical components is a very current topic. Therefore, some investigations are focused on this area, so that the aging of the optical components is accelerated by thermal, high power and gamma load. This paper deals by findings of the influence of the load by laser with high optical power on the transmission parameters of the optical coupler. The investigated coupler has one input and eight outputs (1x8). Load by laser with high optical power is realized using a fiber laser with a cascade configuration EDFA amplifiers. The output power of the amplifier is approximately 250 mW. Duration of the load is moving from 104 hours to 139 hours. After each load, input power and output powers of all branches are measured. Following parameters of the optical coupler are calculated using formulas: the insertion losses of the individual branches, split ratio, total losses, homogeneity of the losses and cross-talk between different branches. All measurements are performed at wavelengths 1310 nm and 1550 nm. Individual optical powers are measured 20 times, due to the exclusion of statistical error of the measurement. After measuring, the coupler is connected to the amplifier for next cycle of the load. The paper contains an evaluation of the results of the coupler before and after four cycles of the burden.

  19. Optimization of Front Axle Suspension System of Articulated Dump Truck

    DEFF Research Database (Denmark)

    Langer, Thomas Heegaard; Christensen, Brian B.; Mouritsen, Ole Ø.

    2010-01-01

    ongoing research collaboration between Hydrema Produktion A/S, Aalborg University and the University of Agder on comfort improvement. The main goal of the research project is to improve ride comfort of articulated construction machinery by use of multibody simulation models. In this paper the application...... that has been subjected to comfort improvement is a two axle articulated dump truck. The comfort has been in terms of whole body vibration exposure and the overall improvement has been made possible by adding front axle suspension. However, a hydraulic stabilizing system between the tractor and trailer...

  20. Eddy current system for inspection of train hollow axles

    Energy Technology Data Exchange (ETDEWEB)

    Chady, Tomasz; Psuj, Grzegorz; Sikora, Ryszard; Kowalczyk, Jacek; Spychalski, Ireneusz [Department of Electrical and Computer Engineering, Faculty of Electrical Engineering, West Pomeranian University of Technology, Szczecin (Poland)

    2014-02-18

    The structural integrity of wheelsets used in rolling stock is of great importance to the safety. In this paper, electromagnetic system with an eddy current transducer suitable for the inspection of hollow axles have been presented. The transducer was developed to detect surface braking defects having depth not smaller than 0.5 mm. Ultrasound technique can be utilized to inspect the whole axle, but it is not sufficiently sensitive to shallow defects located close to the surface. Therefore, the electromagnetic technique is proposed to detect surface breaking cracks that cannot be detected by ultrasonic technique.

  1. Design and Development of Animal Drawn Ground Metered Axle Mechanism Boom Sprayer

    Directory of Open Access Journals (Sweden)

    Michael C. Amonye

    2014-09-01

    Full Text Available A spraying technology was developed for use by rural farmers in Northern Nigeria. The farming systems in these areas are put into consideration and in keeping with appropriate technology initiative. The technology was designed to offer the farmers an equitable sprayer that shall be drawn by animal farm power and that is effective and affordable. The equipment was constructed using the parameters obtained from design and tested at a farmland within the University premises of Ahmadu Bello University, Zaria, in Nigeria. The equipment consists of a boom with multiple Controlled Droplet Applicator (CDA atomizer nozzles, a gear pump, a chemical tank, and chair for an operator; all attached to a framework bolted to a rear axle. It was observed that the Dynamic Wheel Load assuming even distribution of load was found to be 1575N and a net pull of 820N. The net pull offers convenient task and shall easily swallow energy requirement for spraying uphill terrains.

  2. Micro-machined high capacity silicon load cells

    NARCIS (Netherlands)

    Zwijze, A.F.

    2000-01-01

    The aim of the research presented in this thesis is to improve the performance of high capacity conventional load cells or force sensors by using silicon as the base material. Silicon is used because it offers the possibility of realising small, light, low cost and high performance mechanical sensor

  3. Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin

    Science.gov (United States)

    Finotti, Alessia; Gasparello, Jessica; Breveglieri, Giulia; Cosenza, Lucia Carmela; Montagner, Giulia; Bresciani, Alberto; Altamura, Sergio; Bianchi, Nicoletta; Martini, Elisa; Gallerani, Eleonora; Borgatti, Monica; Gambari, Roberto

    2015-01-01

    Induction of fetal hemoglobin (HbF) is considered a promising strategy in the treatment of β-thalassemia, in which production of adult hemoglobin (HbA) is impaired by mutations affecting the β-globin gene. Recent results indicate that B-cell lymphoma/leukemia 11A (BCL11A) is a major repressor of γ-globin gene expression. Therefore, disrupting the binding of the BCL11A transcriptional repressor complex to the γ-globin gene promoter provides a novel approach for inducing expression of the γ-globin genes. To develop a cellular screening system for the identification of BCL11A inhibitors, we produced K562 cell clones with integrated copies of a BCL11A-XL expressing vector. We characterized 12 K562 clones expressing different levels of BCL11A-XL and found that a clear inverse relationship does exist between the levels of BCL11A-XL and the extent of hemoglobinization induced by a panel of HbF inducers. Using mithramycin as an inducer, we found that this molecule was the only HbF inducer efficient in rescuing the ability to differentiate along the erythroid program, even in K562 cell clones expressing high levels of BCL11A-XL, suggesting that BCL11A-XL activity is counteracted by mithramycin. PMID:26342260

  4. Kinome-wide shRNA Screen Identifies the Receptor Tyrosine Kinase AXL as a Key Regulator for Mesenchymal Glioblastoma Stem-like Cells

    Directory of Open Access Journals (Sweden)

    Peng Cheng

    2015-05-01

    Full Text Available Glioblastoma is a highly lethal cancer for which novel therapeutics are urgently needed. Two distinct subtypes of glioblastoma stem-like cells (GSCs were recently identified: mesenchymal (MES and proneural (PN. To identify mechanisms to target the more aggressive MES GSCs, we combined transcriptomic expression analysis and kinome-wide short hairpin RNA screening of MES and PN GSCs. In comparison to PN GSCs, we found significant upregulation and phosphorylation of the receptor tyrosine kinase AXL in MES GSCs. Knockdown of AXL significantly decreased MES GSC self-renewal capacity in vitro and inhibited the growth of glioblastoma patient-derived xenografts. Moreover, inhibition of AXL with shRNA or pharmacologic inhibitors also increased cell death significantly more in MES GSCs. Clinically, AXL expression was elevated in the MES GBM subtype and significantly correlated with poor prognosis in multiple cancers. In conclusion, we identified AXL as a potential molecular target for novel approaches to treat glioblastoma and other solid cancers.

  5. LSTM-Based Temperature Prediction for Hot-Axles of Locomotives

    Directory of Open Access Journals (Sweden)

    Luo Can

    2017-01-01

    Full Text Available The reliability of locomotives plays a central role for the smooth operation of railway systems. Hot-axle failures are one of the most commonly found problems leading to locomotive accidents. Since the operating status of the locomotive axle bearings can be distinctly reflected by the axle temperatures, online temperature monitoring has become an essential way to detect hot-axle failures. In this work, we explore the feasibility of predict the hot-axle failures by identifying the temperature from predicted nominal values. We propose a data-driven approach based on the Long Short-Term Memory (LSTM network to predict the sensor temperature for axle bearings. The effectiveness of the prediction model was validated with operation data collected from commercial locomotives. With a prediction accuracy is within a few percent, the proposed techniques can be used as a dynamic reference for hot-axle monitoring.

  6. Manual Drivetrain and Axles Specialist. Teacher Edition. Automotive Service Series.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This instructor's guide contains materials for teaching the manual drive trains and axle specialist component of a competency-based instructional program for students preparing for employment in the automotive service trade. It is based on National Institute of Automotive Service Excellence task lists. Six instructional units contain materials…

  7. DACIA LOGAN LIVE AXLE OPTIMISATION USING COMPUTER GRAPHICS

    Directory of Open Access Journals (Sweden)

    KIRALY Andrei

    2017-05-01

    Full Text Available The paper presents some contributions to the calculus and optimisation of a live axle used at Dacia Logan using computer graphics software for creating the model and afterwards using FEA evaluation to determine the effectiveness of the optimisation. Thus using specialized computer software, a simulation is made and the results were compared to the measured real prototype.

  8. Inhibition of Axl improves the targeted therapy against ALK-mutated neuroblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Fei [Department of Neurology, Sichuan Medical Science Institute and Sichuan Provincial Hospital, Chengdu 610072 (China); Li, Hongling [Department of Radiotherapy, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 201620 (China); Sun, Yong, E-mail: sunfanqi2010@163.com [Department of Burn and Plastic Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300 (China)

    2014-11-28

    Highlights: • First reported Axl is co-expressed with ALK in neuroblastoma tissues and cell lines. • Axl activation promotes cell growth and impairs the efficiency of ALK inhibitor. • Further found silence of Axl leads to increased sensitivity to ALK inhibitors. • Axl inhibitor promotes the efficiency of targeted therapy in vitro and in vivo. • Axl activation should be considered in the clinical application of ALK inhibitors. - Abstract: Neuroblastoma (NB) patients harboring mutated ALK can be expected to potentially benefit from targeted therapy based on ALK tyrosine kinase inhibitor (TKI), such as crizotinib and ceritinib. However, the effect of the treatment varies with different individuals, although with the same genic changes. Axl receptor tyrosine kinase is expressed in a variety of human cancers, but little data are reported in NB, particularly in which carrying mutated ALK. In this study, we focus on the roles of Axl in ALK-mutated NB for investigating rational therapeutic strategy. We found that Axl is expressed in ALK-positive NB tissues and cell lines, and could be effectively activated by its ligand GAS6. Ligand-dependent Axl activation obviously rescued crizotinib-mediated suppression of cell proliferation in ALK-mutated NB cells. Genetic inhibition of Axl with specific small interfering RNA markedly increased the sensitivity of cells to ALK-TKIs. Furthermore, a small-molecule inhibitor of Axl significantly enhanced ALK-targeted therapy, as an increased frequency of apoptosis was observed in NB cells co-expressing ALK and Axl. Taken together, our results demonstrated that activation of Axl could lead to insensitivity to ALK inhibitors, and dual inhibition of ALK and Axl might be a potential therapeutic strategy against ALK-mutated NB.

  9. Sunitinib activates Axl signaling in renal cell cancer.

    Science.gov (United States)

    van der Mijn, Johannes C; Broxterman, Henk J; Knol, Jaco C; Piersma, Sander R; De Haas, Richard R; Dekker, Henk; Pham, Thang V; Van Beusechem, Victor W; Halmos, Balazs; Mier, James W; Jiménez, Connie R; Verheul, Henk M W

    2016-06-15

    Mass spectrometry-based phosphoproteomics provides a unique unbiased approach to evaluate signaling network in cancer cells. The tyrosine kinase inhibitor sunitinib is registered as treatment for patients with renal cell cancer (RCC). We investigated the effect of sunitinib on tyrosine phosphorylation in RCC tumor cells to get more insight in its mechanism of action and thereby to find potential leads for combination treatment strategies. Sunitinib inhibitory concentrations of proliferation (IC50) of 786-O, 769-p and A498 RCC cells were determined by MTT-assays. Global tyrosine phosphorylation was measured by LC-MS/MS after immunoprecipitation with the antiphosphotyrosine antibody p-TYR-100. Phosphoproteomic profiling of 786-O cells yielded 1519 phosphopeptides, corresponding to 675 unique proteins including 57 different phosphorylated protein kinases. Compared to control, incubation with sunitinib at its IC50 of 2 µM resulted in downregulation of 86 phosphopeptides including CDK5, DYRK3, DYRK4, G6PD, PKM and LDH-A, while 94 phosphopeptides including Axl, FAK, EPHA2 and p38α were upregulated. Axl- (y702), FAK- (y576) and p38α (y182) upregulation was confirmed by Western Blot in 786-O and A498 cells. Subsequent proliferation assays revealed that inhibition of Axl with a small molecule inhibitor (R428) sensitized 786-O RCC cells and immortalized endothelial cells to sunitinib up to 3 fold. In conclusion, incubation with sunitinib of RCC cells causes significant upregulation of multiple phosphopeptides including Axl. Simultaneous inhibition of Axl improves the antitumor activity of sunitinib. We envision that evaluation of phosphoproteomic changes by TKI treatment enables identification of new targets for combination treatment strategies.

  10. The effect of high load training on psychomotor speed

    NARCIS (Netherlands)

    Nederhof, E.; Lemmink, K.; Zwerver, J.; Mulder, T.

    The purpose of the present study was to investigate whether overreached athletes show psychomotor slowness after a period of high load training. Fourteen well-trained cyclists (10 male, 4 female, mean age 25.3 [SD = 4.1] years, mean maximal oxygen consumption 65.5 [SD=8.1] ml/ kg-min) performed a

  11. Applicability of hydraulic dynamometer for measuring load mass on forwarders

    Directory of Open Access Journals (Sweden)

    Pandur Zdravko

    2015-01-01

    Full Text Available In the last few years, with the start of wood biomass production from wood residues, the need for determining the quantity of extracted wood residuals on a landing site has appeared. The beginning of intensive usage of wood residues for wood biomass starts in lowland forest where all wood residues are extracted with forwarders. There are several ways to determine load mass on a forwarder, first and probably most accurate is the use of load cells which are installed between forwarder undercarriage and loading space. In Croatia, as far as it is known, there is no forwarder with such equipment, although manufacturers offer the installation of such equipment when buying a new forwarder. The second option is using a portable measuring platform (axle scale which was already used for research of axle loads of trucks and forwarders. The data obtained with the measuring platform are very accurate, while its deficiency is relatively great mass, large dimensions and high price. The third option is determining mass by using hydraulic dynamometer which is installed on crane between the rotator and the telescopic boom. The production and installation of such a system is very simple, and with the price it can easily compete with previously described measuring systems. The main deficiency of this system is its unsatisfying accuracy. The results of assortment mass measuring with hydraulic dynamometer installed on a hydraulic crane and discussion on factors influencing obtained results will be presented in this paper.

  12. A Comparison of Increases in Volume Load Over 8 Weeks of Low-Versus High-Load Resistance Training

    OpenAIRE

    Schoenfeld; Ogborn; Contreras,, J. g.; Cappaert; Silva Ribeiro; Alvar; Vigotsky

    2016-01-01

    Background It has been hypothesized that the ability to increase volume load (VL) via a progressive increase in the magnitude of load for a given exercise within a given repetition range could enhance the adaptive response to resistance training. Objectives The purpose of this study was to compare changes in volume load (VL) over eight weeks of resistance training (RT) in high-versus low-load protocols. ...

  13. High functional load inhibits phonological contrast loss: a corpus study.

    Science.gov (United States)

    Wedel, Andrew; Kaplan, Abby; Jackson, Scott

    2013-08-01

    For nearly a century, linguists have suggested that diachronic merger is less likely between phonemes with a high functional load--that is, phonemes that distinguish many words in the language in question. However, limitations in data and computational power have made assessing this hypothesis difficult. Here we present the first larger-scale study of the functional load hypothesis, using data from sound changes in a diverse set of languages. Our results support the functional load hypothesis: phoneme pairs undergoing merger distinguish significantly fewer minimal pairs in the lexicon than unmerged phoneme pairs. Furthermore, we show that higher phoneme probability is positively correlated with merger, but that this effect is stronger for phonemes that distinguish no minimal pairs. Finally, within our dataset we find that minimal pair count and phoneme probability better predict merger than change in system entropy at the lexical or phoneme level.

  14. Atomistic simulations of high strain rate loading of nanocrystals

    Science.gov (United States)

    Bringa, E. M.; Tramontina, D.; Ruestes, C. J.; Tang, Y.; Meyers, M. A.; Gunkelmann, N.; Urbassek, H. M.

    2013-03-01

    Materials loaded at high strain rates can reach extreme temperature and pressure conditions. Most experiments on loading of simple materials use poly crystals, while most atomistic simulations of shock wave loading deal with single crystals, due to the higher computational cost of running polycrystal samples. Of course, atomistic simulations of polycrystals with micron-sized grains are beyond the capabilities of current supercomputers. On the other hand, nanocrystals (nc) with grain sizes below 50 nm can be obtained experimentally and modeled reasonably well at high strain rates, opening the possibility of nearly direct comparison between atomistic molecular dynamics (MD) simulations and experiments using high power lasers. We will discuss MD simulations and links to experiments for nc Cu and Ni, as model f.c.c. solids, and nc Ta and Fe, as model b.c.c. solids. In all cases, the microstructure resulting from loading depends strongly on grain size, strain rate and peak applied pressure. We will also discuss effects related to target porosity in nc's. E.M.B. thanks funding from PICT2008-1325.

  15. Part-load performance of a high temperature Kalina cycle

    DEFF Research Database (Denmark)

    Modi, Anish; Andreasen, Jesper Graa; Kærn, Martin Ryhl

    2015-01-01

    The Kalina cycle has recently seen increased interest as an alternative to the conventional steam Rankine cycle. The cycle has been studied for use with both low and high temperature applications such as geothermal power plants, ocean thermal energy conversion, waste heat recovery, gas turbine...... bottoming cycle, and solar power plants. The high temperature cycle layouts are inherently more complex than the low temperature layouts due to the presence of a distillation-condensation subsystem, three pressure levels, and several heat exchangers. This paper presents a detailed approach to solve...... the Kalina cycle in part-load operating conditions for high temperature (a turbine inlet temperature of 500 °C) and high pressure (100 bar) applications. A central receiver concentrating solar power plant with direct vapour generation is considered as a case study where the part-load conditions are simulated...

  16. Passivation and Corrosion Behavior of Modified Ferritic-Pearlitic Railway Axle Steels

    Science.gov (United States)

    Moon, A. P.; Sangal, S.; Srivastav, Simant; Gajbhiye, N. S.; Mondal, K.

    2015-01-01

    Electrochemical polarization behavior of two newly developed ferritic-pearlitic railway axle steels (MS3 and MS6) and the standard Indian conventional axle steel has been studied in sodium borate buffer solution of pH 8.4 with and without the presence of NaCl. The polarization behavior of both the new axle steels shows close resemblance, whereas, different polarization behavior has been observed for the conventional axle steel. Electrochemical impedance spectroscopy measurements have clearly reflected significantly improved passivation behavior for the newly developed steels compared to that of the conventional axle steel. NaCl salt fog exposure tests have also shown superior corrosion resistance of the newly developed axle steels as compared to the conventional axle steel. Higher surface roughness on the corroded conventional axle steel has also been observed compared to the smoother surface in case of the new axle steels. Higher corrosion resistance of the new axle steels has been attributed to their finer microstructure and strongly adherent protective rusts.

  17. Influence of linear profile modification and loading conditions on the dynamic tooth load and stress of high contact ratio gears

    Science.gov (United States)

    Lee, Chinwai; Lin, Hsiang Hsi; Oswald, Fred B.; Townsend, Dennis P.

    1990-01-01

    A computer simulation for the dynamic response of high-contact-ratio spur gear transmissions is presented. High contact ratio gears have the potential to produce lower dynamic tooth loads and minimum root stress but they can be sensitive to tooth profile errors. The analysis presented examines various profile modifications under realistic loading conditions. The effect of these modifications on the dynamic load (force) between mating gear teeth and the dynamic root stress is presented. Since the contact stress is dependent on the dynamic load, minimizing dynamic loads will also minimize contact stresses. It is shown that the combination of profile modification and the applied load (torque) carried by a gear system has a significant influence on gear dynamics. The ideal modification at one value of applied load will not be the best solution for a different load. High-contact-ratio gears were found to require less modification than standard low-contact-ratio gears. High-contact-ratio gears are more adversely affected by excess modification than by under modification. In addition, the optimal profile modification required to minimize the dynamic load (hence the contact stress) on a gear tooth differs from the optimal modification required to minimize the dynamic root (bending) stress. Computer simulation can help find the design tradeoffs to determine the best profile modification to satisfy the conflicting constraints of minimizing both the load and root stress in gears which must operate over a range of applied loads.

  18. High-speed seatbelt pretensioner loading of the abdomen.

    Science.gov (United States)

    Foster, Craig D; Hardy, Warren N; Yang, King H; King, Albert I; Hashimoto, Syuzo

    2006-11-01

    This study characterizes the response of the human cadaver abdomen to high-speed seatbelt loading using pyrotechnic pretensioners. A test apparatus was developed to deliver symmetric loading to the abdomen using a seatbelt equipped with two low-mass load cells. Eight subjects were tested under worst-case scenario, out-of-position (OOP) conditions. A seatbelt was placed at the level of mid-umbilicus and drawn back along the sides of the specimens, which were seated upright using a fixed-back configuration. Penetration was measured by a laser, which tracked the anterior aspect of the abdomen, and by high-speed video. Additionally, aortic pressure was monitored. Three different pretensioner designs were used, referred to as system A, system B and system C. The B and C systems employed single pretensioners. The A system consisted of two B system pretensioners. The vascular systems of the subjects were perfused. Peak anterior abdominal loads due to the seatbelt ranged from 2.8 kN to 10.1 kN. Peak abdominal penetration ranged from 49 mm to 138 mm. Peak penetration speed ranged from 4.0 m/s to 13.3 m/s. Three cadavers sustained liver injury: one AIS 2, and two AIS 3. Cadaver abdominal response corridors for the A and B system pretensioners are proposed. The results are compared to the data reported by Hardy et al. (2001) and Trosseille et al. (2002).

  19. High Hydrogen Loading of Thin Palladium Wires Through

    CERN Document Server

    Celani, F; Marini, P; Di Stefano, V; Nakamura, M; Pace, S; Vecchione, A; Mancini, A; Tripodi, P; Di Gioacchino, D

    2000-01-01

    A new protocol for the electrolytic loading of hydrogen (H) in thin palladium (Pd) wires has been developed. In order to increase the cathodic overvoltage, which is known to be the main parameter capable to enhance the electrolytic $9 H loading of Pd, the catalytic action of the Pd surface versus H-H recombination has been strongly reduced by precipitation of a thin layer of alkaline-earth carbonates on the cathode. A set of electrolytes has been employed, $9 containing small amounts of hydrochloric or sulphuric acid and strontium or calcium ions. The H loading has been continuously evaluated through ac measurements of the Pd wire resistance. Uncommonly low resistivity values, leading to $9 an estimate of exceptionally high H loading, have been observed. Evidence of the existence of a new phase in the very high H content region of the Pd-H system has been inferred on the basis of the determination of the temperature $9 coefficient of the electrical resistivity. For this purpose a thin layer of Hg was galvanic...

  20. NASA/GE Highly-Loaded Turbine Research Program

    Science.gov (United States)

    Giel, Paul W.

    2008-01-01

    An overview of the NASA/GE Highly-Loaded Turbine Research Program at the NASA Glenn Research Center is presented. The program is sponsored by the Subsonic Fixed Wing Project of the Fundamental Aeronautics Program. The goals of the turbine research program are presented along with their relationship to the higher-level program goals. Two turbine research programs are described; the highly-loaded, single-stage high pressure turbine (HPT) and the highly loaded low pressure turbine (LPT). The HPT program is centered on an extremely high pressure ratio single-stage turbine with an engine stage pressure ratio of 5.5. It was designed with a 33% increase in stage loading. It has shown performance levels 2 points better than current engines operating at the higher work level. Some advantages of the turbine include reduced weight and parts count. Optimization of the blade shape to reduce shock losses is described. The LPT program utilizes a four-stage low pressure turbine with an integral first stage vane/transition duct strut; counterrotation; low-solidity blading; fully optimized flowpath including vanes, blades, and endwalls; and a fluidically controlled turbine vane frame/exit guide vane. The implementation of the LPT into GE s and NASA s test facilities is described. A description of NASA s Single Spool Turbine Facility that is currently under renovation is given. The new, upgraded facility is compared to its predecessor. Renovation design requirements are outlined. Facility limits on pressures, temperatures, flow rates, rotational speeds, and power absorption are described. The current renovation status is given.

  1. Optic-electronic systems for measurement the three-dimension angular deformation of axles at the millimeter wave range radiotelescope

    Science.gov (United States)

    Konyakhin, Igor A.; Kopylova, Tatyana V.; Konyakhin, Alexsey I.; Smekhov, Andrey A.

    2013-01-01

    Researches in the millimetre wave range require the high accuracy for position of the mirror components of the radiotelescope. A mirror weight is the cause of the three-dimension angular deformation of the elevation axle and azimuth axle relatively bearings. At result the elevation angle and azimuth angle of a parabolic mirror axis orientation is not equal to the set values. For the measuring roll, pitch and yaw angular deformations the autocollimation system with new type of the reflector are used. Reflector for autocollimation measurements as compositions of the anamorphic prism and special tetrahedral reflector is described. New methods for roll, pitch, yaw angles measuring are discussed. Optical scheme for the measurement system, structure the anamorphic prism and tetrahedral reflector are proposed. Equations for the static characteristic of the measuring system are shown.

  2. Accelerated Life Test Design for Tractor Powertrain Front Axle

    Directory of Open Access Journals (Sweden)

    Ismail Azianti

    2016-01-01

    Full Text Available Accelerated Life Test (ALT has been applied in the manufacturing for many years due to rapid changing technologies, more complex products, speedier product development, and more demanding customer requirements. These reasons have pushed the manufacturers to acquire reliability information faster. ALT allows reducing the time needed to show the reliability of the product. The purpose of this study is to design accelerated life testing which involved determination of normal test time, acceleration factor, acceleration test time, and finally experimental setup. This case study provides the basis for ALT designs for the tractor front axle based on customer usage and field failure analysis, which were conducted to estimate the current reliability, especially on the B10 life during the operational stage of the product. The accelerated life test conducted has guaranteed the B10 life of 4,000 hours with 90% confidence level for lesser time needed for testing to show the reliability of the front axle assembly.

  3. Dynamic Modelling of Axle Tramp in a Sport Type Car

    Directory of Open Access Journals (Sweden)

    Ali Zargartalebi

    2013-01-01

    Full Text Available One of the most significant dynamic aspects of coupled vibration of transmission system and dependent type suspension systems is axle tramp. The tramp is defined as undesirable oscillation of rigid live axle around roll axis. In spite of utilizing powerful engines in some type of sport cars, tramp occurrence causes loss of longitudinal performance. The aim of this paper is to derive a mathematical model for predicting and classifying of the tramp. A parameter study reveals that, some parameters such as engine torque, moving parts moment of inertia, car and wheels weight and the material used in suspension system play important role in controlling the tramp. It is shown that large difference between sprung and unsprung mass moment of inertia around the roll-axis, low vehicle mass, short rear track and medium damping values have significant effects on the severity of tramp.

  4. High Heat-Load Slits for the PLS Multipole Wiggler

    CERN Document Server

    Gil, Kyehwan; Kim, Young-Chan; Lee, Heung-Soo; Wha Chung, Chin

    2005-01-01

    The HFMX (High Flux Macromolecular X-ray crystallography) beamline under commissioning at Pohang Accelerator Laboratory uses beam from a multipole wiggler for MAD experiment. Two horizontal and vertical slits relevant to high heat load are installed at its front-end. In order to treat high heat load and to reduce beam scattering, the horizontal slit has two glidcop blocks with 10° of vertical inclination and its tungsten blades defining beam size are bolted on backsides of both blocks. The blocks of the slit are adjusted on fixed slides by two actuating bars, respectively. Water through channels machined along the actuating bars cool down the heat load of both blocks. The vertical slit has the same structure as the horizontal slit except its installation direction and angle of vertical inclination. The installed slits show stable operation performance and no alignment for the blocks is required by virtue of a pair of blocks translating on slides. The cooling performance of two slits is also shown to ...

  5. Behavior of high strength concrete columns under eccentric loads

    Directory of Open Access Journals (Sweden)

    Hany A. Kottb

    2015-04-01

    Full Text Available In recent decades, high strength concrete (HSC has been widely accepted by designers and contractors to be used in concrete structures, especially in high compressive stress elements. The research aims to study the behavior of high strength concrete columns under eccentric compression using experimental and analytical programs. The research is divided into two main parts; the first part is an experimental investigation for ten square columns tested at the Cairo University Concrete Research Laboratory. The main studied parameters were eccentricity of the applied load, column slenderness ratio; and ratios of longitudinal and transverse reinforcement. The second part is analytical analysis using nonlinear finite element program ANSYS11 on nineteen columns (ten tested square columns and nine rectangular section columns to study the effect of the previous parameters on the column ultimate load, mid-height displacement, and column cracking patterns. The analyzed columns revealed a good agreement with the experimental results with an average difference of 16% and 17% for column ultimate load and mid-height displacement respectively. Results showed an excellent agreement for cracking patterns. Predictions of columns capacities using the interaction diagrams based on ACI 318-08 stress block parameters indicated a safe design procedure of HSC columns under eccentric compression, with ACI 318-08 being more conservative for moderate reinforced HSC columns.

  6. Fabrication of interconnected microporous biomaterials with high hydroxyapatite nanoparticle loading

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Wei; Yao Donggang [School of Polymer Textile and Fiber Engineering, Georgia Institute of Technology, Atlanta, GA (United States); Zhang Qingwei; Lelkes, Peter I [School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104 (United States); Zhou, Jack G, E-mail: yao@gatech.ed [Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA 19104 (United States)

    2010-09-15

    Hydroxyapatite (HA) is known to promote osteogenicity and enhance the mechanical properties of biopolymers. However, incorporating a large amount of HA into a porous biopolymer still remains a challenge. In the present work, a new method was developed to produce interconnected microporous poly(glycolic-co-lactic acid) (PLGA) with high HA nanoparticle loading. First, a ternary blend comprising PLGA/PS (polystyrene)/HA (40/40/20 wt%) was prepared by melt blending under conditions for formation of a co-continuous phase structure. Next, a dynamic annealing stage under small-strain oscillation was applied to the blend to facilitate nanoparticle redistribution. Finally, the PS phase was sacrificially extracted, leaving a porous matrix. The results from different characterizations suggested that the applied small-strain oscillation substantially accelerated the migration of HA nanoparticles during annealing from the PS phase to the PLGA phase; nearly all HA particles were uniformly presented in the PLGA phase after a short period of annealing. After dissolution of the PS phase, a PLGA material with interconnected microporous structure was successfully produced, with a high HA loading above 30 wt%. The mechanisms beneath the experimental observations, particularly on the enhanced particle migration process, were discussed, and strategies for producing highly particle loaded biopolymers with interconnected microporous structures were proposed.

  7. Measurement-Based Vehicle Load Model for Urban Expressway Bridges

    Directory of Open Access Journals (Sweden)

    Bin Chen

    2014-01-01

    Full Text Available Significant changes in vehicle loads have occurred in China due to the development of the automobile industry and transportation within the past two decades, particularly the rapid increase in traffic flow and the large-scale emergence of heavy trucks. However, research into vehicle loadings on urban bridges is not well developed. In this study, based on traffic flow data collected using a weigh-in-motion system installed on an expressway in an urban logistics zone, we analyzed the traffic flow, vehicle types, and gross vehicle weight (GVW features and developed models for the vehicle load and fatigue load. According to the axle space, axle types, and axle number, the trucks in the traffic flow were classified into 10 representative vehicle types. The probability distribution of the GVW was fitted to a three-class mixed log-normal distribution. Using the improved Gumbel method, we determined the extreme value distribution of the vehicle loadings in the purpose reference period and assessed the vehicle loadings of urban bridges. In addition, using the equivalent damage theory, six equivalent vehicle models were established according to the measurements of the axle weight and axle space, thereby obtaining a simplified model of fatigue vehicle loadings on urban expressway bridges.

  8. Influence of axle-wheel interface on ultrasonic testing of fatigue cracks in wheelset.

    OpenAIRE

    Makino, Kazunari; Biwa, Shiro

    2013-01-01

    For the ultrasonic testing at the wheel seat of railway axles, quantitative investigation of the reflection and transmission phenomena at the axle-wheel interface is important. This paper describes the influence of the axle-wheel interface on the ultrasonic testing of a fatigue crack in a wheelset by applying the spring interface model. The normal and tangential stiffnesses were identified experimentally for an as-manufactured wheelset at the normal incidence, and the reflection coefficient f...

  9. Design and application of the car front axle road simulation test%轿车前桥道路模拟台架疲劳试验设计及应用

    Institute of Scientific and Technical Information of China (English)

    韩峰; 李国峰; 于翠

    2016-01-01

    This paper based on the vertical force, vertical force, lateral force of automobile front axle head and the hydraulic system (MTS), and one vehicle model in the proving ground of front axle load spectrum to design bench test for fatigue. Road simulation was carried out on the front axle. To reduce the design cost, shorten the design time, produce good economic benefit.%文章基于前桥轴头垂直力、纵向力、侧向力和 MTS 液压系统,以及某车型在试验场实测得到的前桥载荷谱,单纯对前桥进行台架道路模拟耐久试验设计。降低设计成本,缩短设计周期,产生较好的经济效益。

  10. Dynamic Analysis of Light Automotive Front Axle Based on FEM%轻型载货汽车前轴的有限元动态特性分析

    Institute of Scientific and Technical Information of China (English)

    王科

    2015-01-01

    汽车前轴是汽车最重要的承重件之一,其设计的可靠性直接影响整车性能的发挥。利用有限元方法研究汽车前轴的动态特性,并通过频率响应提取动刚度,为前轴设计提供了频域的设计方法。%Front axle of the light truck is one of the most important load-bearing parts. Its design reliability has impact on the vehicle performance. In this paper, the dynamic characteristics of the automotive front axle is researched by using the finite el-ement method ( FEM) , and its dynamic stiffness is also extracted with frequency response. We hope that would provide a de-sign method for front axle in the frequency domain.

  11. Laboratory Based Axle Lubricant Efficiency Evaluation

    Science.gov (United States)

    2014-07-01

    cycle. From there the current gear ratio of the transmission was used to calculate the output torque and speed leaving the transmission. The torque ... gear ratio at speed, S TTransOut = Estimated transmission output torque at speed, S STransOut = Transmission output speed and engine speed...were the engine speed, engine load at speed, transmission gear , transmission output shaft speed, vehicle speed, and the torque converter lockup

  12. A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control.

    Science.gov (United States)

    Budagian, Vadim; Bulanova, Elena; Orinska, Zane; Thon, Lutz; Mamat, Uwe; Bellosta, Paola; Basilico, Claudio; Adam, Dieter; Paus, Ralf; Bulfone-Paus, Silvia

    2005-12-21

    Discrimination between cytokine receptor and receptor tyrosine kinase (RTK) signaling pathways is a central paradigm in signal transduction research. Here, we report a 'promiscuous liaison' between both receptors that enables interleukin (IL)-15 to transactivate the signaling pathway of a tyrosine kinase. IL-15 protects murine L929 fibroblasts from tumor necrosis factor alpha (TNFalpha)-induced cell death, but fails to rescue them upon targeted depletion of the RTK, Axl; however, Axl-overexpressing fibroblasts are TNFalpha-resistant. IL-15Ralpha and Axl colocalize on the cell membrane and co-immunoprecipitate even in the absence of IL-15, whereby the extracellular part of Axl proved to be essential for Axl/IL-15Ralpha interaction. Most strikingly, IL-15 treatment mimics stimulation by the Axl ligand, Gas6, resulting in a rapid tyrosine phosphorylation of both Axl and IL-15Ralpha, and activation of the phosphatidylinositol 3-kinase/Akt pathway. This is also seen in mouse embryonic fibroblasts from wild-type but not Axl-/- or IL-15Ralpha-/- mice. Thus, IL-15-induced protection from TNFalpha-mediated cell death involves a hitherto unknown IL-15 receptor complex, consisting of IL-15Ralpha and Axl RTK, and requires their reciprocal activation initiated by ligand-induced IL-15Ralpha.

  13. Glycol-Substitute for High Power RF Water Loads

    CERN Document Server

    Ebert, Michael

    2005-01-01

    In water loads for high power rf applications, power is dissipated directly into the coolant. Loads for frequencies below approx. 1GHz are ordinarily using an ethylene glycol-water mixture as coolant. The rf systems at DESY utilize about 100 glycol water loads with powers ranging up to 600kW. Due to the increased ecological awareness, the use of glycol is now considered to be problematic. In EU it is forbidden to discharge glycol into the waste water system. In case of cooling system leakages one has to make sure that no glycol is lost. Since it is nearly impossible to avoid any glycol loss in large rf systems, a glycol-substitute was searched for and found. The found sodium-molybdate based substitute is actually a additive for corrosion protection in water systems. Sodium-molybdate is ecologically harmless; for instance, it is also used as fertilizer in agriculture. A homoeopathic dose of 0.4% mixed into deionised water gives better rf absorption characteristics than a 30% glycol mixture. The rf coolant feat...

  14. Experimental investigation of bond strength under high loading rates

    Science.gov (United States)

    Michal, Mathias; Keuser, Manfred; Solomos, George; Peroni, Marco; Larcher, Martin; Esteban, Beatriz

    2015-09-01

    The structural behaviour of reinforced concrete is governed significantly by the transmission of forces between steel and concrete. The bond is of special importance for the overlapping joint and anchoring of the reinforcement, where rigid bond is required. It also plays an important role in the rotational capacity of plastic hinges, where a ductile bond behaviour is preferable. Similar to the mechanical properties of concrete and steel also the characteristics of their interaction changes with the velocity of the applied loading. For smooth steel bars with its main bond mechanisms of adhesion and friction, nearly no influence of loading rate is reported in literature. In contrast, a high rate dependence can be found for the nowadays mainly used deformed bars. For mechanical interlock, where ribs of the reinforcing steel are bracing concrete material surrounding the bar, one reason can be assumed to be in direct connection with the increase of concrete compressive strength. For splitting failure of bond, characterized by the concrete tensile strength, an even higher dynamic increase is observed. For the design of Structures exposed to blast or impact loading the knowledge of a rate dependent bond stress-slip relationship is required to consider safety and economical aspects at the same time. The bond behaviour of reinforced concrete has been investigated with different experimental methods at the University of the Bundeswehr Munich (UniBw) and the Joint Research Centre (JRC) in Ispra. Both static and dynamic tests have been carried out, where innovative experimental apparatuses have been used. The bond stress-slip relationship and maximum pull-out-forces for varying diameter of the bar, concrete compressive strength and loading rates have been obtained. It is expected that these experimental results will contribute to a better understanding of the rate dependent bond behaviour and will serve for calibration of numerical models.

  15. Experimental investigation of bond strength under high loading rates

    Directory of Open Access Journals (Sweden)

    Michal Mathias

    2015-01-01

    Full Text Available The structural behaviour of reinforced concrete is governed significantly by the transmission of forces between steel and concrete. The bond is of special importance for the overlapping joint and anchoring of the reinforcement, where rigid bond is required. It also plays an important role in the rotational capacity of plastic hinges, where a ductile bond behaviour is preferable. Similar to the mechanical properties of concrete and steel also the characteristics of their interaction changes with the velocity of the applied loading. For smooth steel bars with its main bond mechanisms of adhesion and friction, nearly no influence of loading rate is reported in literature. In contrast, a high rate dependence can be found for the nowadays mainly used deformed bars. For mechanical interlock, where ribs of the reinforcing steel are bracing concrete material surrounding the bar, one reason can be assumed to be in direct connection with the increase of concrete compressive strength. For splitting failure of bond, characterized by the concrete tensile strength, an even higher dynamic increase is observed. For the design of Structures exposed to blast or impact loading the knowledge of a rate dependent bond stress-slip relationship is required to consider safety and economical aspects at the same time. The bond behaviour of reinforced concrete has been investigated with different experimental methods at the University of the Bundeswehr Munich (UniBw and the Joint Research Centre (JRC in Ispra. Both static and dynamic tests have been carried out, where innovative experimental apparatuses have been used. The bond stress-slip relationship and maximum pull-out-forces for varying diameter of the bar, concrete compressive strength and loading rates have been obtained. It is expected that these experimental results will contribute to a better understanding of the rate dependent bond behaviour and will serve for calibration of numerical models.

  16. 大功率机车静态称重系统的设计与实现%The design and implementation of high power locomotive static weighing system

    Institute of Scientific and Technical Information of China (English)

    张玉东; 伏滨; 高绍和; 杨纪富

    2015-01-01

    Articleabstract:To solve the problem after the new manufacture, use, repair of high power locomotive wheel load, axle load partial load problem, high-power locomotive static weighing system is designed and developed, the system through the detection of locomotive wheel load, axle load, heavy truck and vehicle weight, through computer processing to calculate the vehicle wheel load, axle load difference and unilateral lateral wheel weight difference, determine the plane of center of gravity of the locomotive, and can be calculated based on test result form guide adjustment scheme of locomotive wheel weight deviation, adjusting spring cushioned by the adjustment plan, so as to realize the locomotive wheel load, axle load balance.%为解决新制造、使用中、修理后的大功率机车轮重、轴重偏载问题,设计开发了大功率机车静态称重系统,该系统通过检测机车的轮重、轴重、转向架重及整车重量,经过计算机处理计算出车辆轮重差、轴重差以及单边侧轮重差,确定出机车的平面重心,并能依据检测结果计算形成指导机车轮重偏差的调整方案,依据调整方案进行调簧加垫,从而实现机车轮重、轴重均载平衡。

  17. Gearbox Reliability Collaborative Investigation of Gearbox Motion and High-Speed-Shaft Loads

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jon [National Renewable Energy Lab. (NREL), Golden, CO (United States); Guo, Yi [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sethuraman, Latha [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-03-18

    This paper extends a model-to-test validation effort to examine the effect of different constant rotor torque and moment conditions and intentional generator misalignment on the gearbox motion and high-speed-shaft loads. Fully validating gearbox motion and high-speed-shaft loads across a range of test conditions is a critical precursor to examining the bearing loads, as the gearbox motion and high-speed-shaft loads are the drivers of these bearing loads.

  18. A Comparison of Increases in Volume Load Over 8 Weeks of Low-Versus High-Load Resistance Training.

    Science.gov (United States)

    Schoenfeld, Brad J; Ogborn, Dan; Contreras, Bret; Cappaert, Tom; Silva Ribeiro, Alex; Alvar, Brent A; Vigotsky, Andrew D

    2016-06-01

    It has been hypothesized that the ability to increase volume load (VL) via a progressive increase in the magnitude of load for a given exercise within a given repetition range could enhance the adaptive response to resistance training. The purpose of this study was to compare changes in volume load (VL) over eight weeks of resistance training (RT) in high-versus low-load protocols. Eighteen well-trained men were matched according to baseline strength were randomly assigned to either a low-load RT (LOW, n = 9) where 25 - 35 repetitions were performed per exercise, or a high-load RT (HIGH, n = 9) where 8 - 12 repetitions were performed per exercise. Both groups performed three sets of seven exercises for all major muscles three times per week on non-consecutive days. After adjusting for the pre-test scores, there was a significant difference between the two intervention groups on post-intervention total VL with a very large effect size (F (1, 15) = 16.598, P = .001, ηp(2) = .525). There was a significant relationship between pre-intervention and post-intervention total VL (F (1, 15) = 32.048, P < .0001, ηp(2) = .681) in which the pre-test scores explained 68% of the variance in the post-test scores. This study indicates that low-load RT results in greater accumulations in VL compared to high-load RT over the course of 8 weeks of training.

  19. Axl receptor tyrosine kinase is a novel target of apigenin for the inhibition of cell proliferation.

    Science.gov (United States)

    Kim, Kyung-Chan; Choi, Eun-Ha; Lee, Chuhee

    2014-08-01

    The Axl receptor tyrosine kinase (RTK), along with Tyro 3 and Mer, belongs to the TAM subfamily that promotes survival, stimulates proliferation and/or inhibits apoptosis. In various types of human cancer, including breast, lung and prostate cancer, Axl expression is increased and correlates with an advanced clinical stage. In this study, we examined whether apigenin has an effect on Axl expression, which in turn can affect cell proliferation. The treatment of the non‑small cell lung cancer (NSCLC) cells, A549 and H460, with apigenin decreased Axl mRNA and protein expression in a dose‑dependent manner. Axl promoter activity was also inhibited by apigenin, indicating that apigenin suppressed Axl expression at the transcriptional level. Upon treatment with apigenin, the viability of both the A549 and H460 cells was gradually decreased and the anti-proliferative effects were further confirmed by the dose‑dependent decrease in the clonogenic ability of the apigenin‑treated cells. Subsequently, we found that the viability and clonogenic ability of the cells treated with apigenin was less or more affected by transfection of the cells with a Axl-expressing plasmid or Axl targeting siRNA, compared to transfection with the empty vector or control siRNA, respectively. In addition, apigenin increased the expression of p21, a cyclin-dependent kinase inhibitor, but reduced the expression of X-linked inhibitor of apoptosis protein (XIAP). These cell cycle arrest and pro-apoptotic effects of apigenin were also attenuated or augmented by the up- or downregulation of Axl expression, respectively, which suggests that Axl is a novel target of apigenin through which it exerts its inhibitory effects on cell proliferation. Taken together, our data indicate that apigenin downregulates Axl expression, which subsequently results in the inhibition of NSCLC cell proliferation through the increase and decrease of p21 and XIAP expression, respectively.

  20. High Heat Load Properties of Ultra Fine Grain Tungsten

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Z.; Du, J.; Ge, C. [Lab. of Special Ceramic and P/M, University of Science and Technology, 100083 Beijing (China); Linke, J.; Pintsuk, G. [FZJ-Forschungszentrum Juelich GmbH, Association Euratom-FZJ, Institut fur Plasmaphysik, Postfach 1913, D-52425 Juelich (Germany); Song, S.X. [Research Center on Fusion Materials (RCFM), University of Science and Technology Beijing (USTB), 100083 Beijing (China)

    2007-07-01

    Full text of publication follows: Tungsten is increasingly considered as a promising candidate armour materials facing the plasma in tokamaks for medium to high heat flux components (EAST, ASDEX, ITER). Fabrication tungsten with ultra fine grain size is considered as an effective way to ameliorate some disadvantages of tungsten, such as its brittleness at room temperature. But the research data on the performance of ultra fine grain tungsten is still very limit. In this work, high heat load properties of pure ultra-fine grain tungsten have been studied. The ultra fine grain tungsten samples with average grain size of 0.2 {mu}m, 1 {mu}m and 3 {mu}m were fabricated by resistance sintering under ultra high pressure. The annealing experiments for the investigation of the material resistance against grain growth have been done by annealing samples in a vacuum furnace at different temperature holding for 2 hours respectively. It is found that recrystallization and grain growth occur at heating temperature of 1250 deg. c. The finer the initial grain sizes of tungsten, the smaller its grain growth grain. The effects of transient high thermal loads (off normal events like disruptions) on tungsten surface morphology have been performed in electron beam test facility JUDITH. The thermal loads tests have been carried out with 4 ms pulses at different power density of 0.22, 0.33, 0.44, 0.55 and 0.88 GW/m{sup 2} respectively. Horizontal cracks formed for all tungsten samples at 0.44 GW/m{sup 2}. Particle erosions occurred for tungsten with 3 {mu}m size at 0.33 GW/m{sup 2} and for tungsten with 0.2 and 1 {mu}m size at 0.55 GW/m{sup 2}. The weight loss of tungsten with 0.2, 1 and 3 {mu}m size are 2,0.1,0.6 mg respectively at 0.88 GW/m{sup 2}. The effects of a large number of very short transient repetitive thermal loads (ELM-like) on tungsten surface morphology also have been performed by using a fundamental wave of a YAG laser. It is found that tungsten with 0.2 {mu}m size has

  1. Survivability of MEMS Packages at High-G Loads

    Science.gov (United States)

    Pryputniewicz, Ryszard J.

    2014-10-01

    Advances in emerging technology of microelectromechanical systems (MEMS) are one of the most challenging tasks in today's experimental mechanics. More specifically, development of these miniature devices requires sophisticated design, analysis, fabrication, testing, and characterization tools that have multiphysics and multiscale capabilities, especially as MEMS are being developed for use at harsh conditions. In harsh-environment and high-performance (e.g., military) guidance applications inertial sensors must be sensitive to low rates of rotation yet survive the high blast loads associated with the initial launch. In this multi-year study, a set of tuning fork gyroscopes were subjected to a series of increasing g-loads (culminating at approximately 60,000 g's) with measurements of shape made after each test. A custom set of test sample packages (aka articles) were hermetically sealed with glass lids to allow optical inspection of components while preserving the operating environment (i.e., vacuum). Initial test measurements were made upon fabrication of the articles. Optical and interferometric measurements have been made prior to and after each shock g-loading. The shape of the tuning fork gyroscope (TFG) test articles was measured using a phase shifting Michelson interferometer with compensation for package cover glass. Full field shape was determined and traces of pertinent structures were extracted for comparison. Failure of the die was observed in the form of fractures below the chip surface as well as fractures in the glass lid sealing the package. Potential causes of the failure are discussed as well as a recommendation for modified packaging techniques to mitigate future component failures.

  2. Workshop on high heat load x-ray optics

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    A workshop on High Heat Load X-Ray Optics'' was held at Argonne National Laboratory on August 3--5, 1989. The object of this workshop was to discuss recent advances in the art of cooling x-ray optics subject to high heat loads from synchrotron beams. The cooling of the first optical element in the intense photon beams that will be produced in the next generation of synchrotron sources is recognized as one of the major challenges that must be faced before one will be able to use these very intense beams in future synchrotron experiments. Considerable advances have been made in this art during the last few years, but much work remains to be done before the heating problem can be said to be completely solved. Special emphasis was placed on recent cooling experiments and detailed finite element'' and finite difference'' calculations comparing experiment with theory and extending theory to optimize performance.

  3. High load vortex oscillations developed in Francis turbines

    Science.gov (United States)

    Rodriguez, D.; Rivetti, A.; Lucino, C.

    2016-11-01

    Francis turbines operating at high load conditions produce a typical flow pattern in the draft tube cone characterized by the presence of an axisymmetric central vortex. This central cavity could become unstable, generating synchronic pressure pulsations, usually called self-excited oscillations, which propagate into the whole machine. The on-set and size of the central vortex cavity depend on the geometry of the runner and draft tube and on the operating point as well. Numerical flow simulations and model tests allow for the characterization of the different flow patterns induced by each particular Francis turbine design and, when studied in combination with the hydraulic system, including the intake and penstock, could predict the prototype hydraulic behavior for the complete operation zone. The present work focuses the CFD simulation on the development and dynamic behavior of the central axisymmetric vortex for a medium-head Francis turbine operating at high load conditions. The CFD simulations are based in two-phase transient calculations. Oscillation frequencies against its cavity volume development were obtained and good correlation was found with experimental results.

  4. Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses

    Directory of Open Access Journals (Sweden)

    Laurent Meertens

    2017-01-01

    Full Text Available ZIKA virus (ZIKV is an emerging pathogen responsible for neurological disorders and congenital microcephaly. However, the molecular basis for ZIKV neurotropism remains poorly understood. Here, we show that Axl is expressed in human microglia and astrocytes in the developing brain and that it mediates ZIKV infection of glial cells. Axl-mediated ZIKV entry requires the Axl ligand Gas6, which bridges ZIKV particles to glial cells. Following binding, ZIKV is internalized through clathrin-mediated endocytosis and traffics to Rab5+ endosomes to establish productive infection. During entry, the ZIKV/Gas6 complex activates Axl kinase activity, which downmodulates interferon signaling and facilitates infection. ZIKV infection of human glial cells is inhibited by MYD1, an engineered Axl decoy receptor, and by the Axl kinase inhibitor R428. Our results highlight the dual role of Axl during ZIKV infection of glial cells: promoting viral entry and modulating innate immune responses. Therefore, inhibiting Axl function may represent a potential target for future antiviral therapies.

  5. 49 CFR 230.100 - Defects in tender truck axles and journals.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Defects in tender truck axles and journals. 230... Steam Locomotives and Tenders Running Gear § 230.100 Defects in tender truck axles and journals. (a... wheel seats that is more than 1/8 of an inch in depth. (b) Tender truck journal condemning...

  6. Heating Processes Of The Axle-Boxes Of Rolling-Stock On Railway Track Curves

    Directory of Open Access Journals (Sweden)

    Olegas Lunys

    2013-12-01

    Full Text Available The article deals with the heating process of the axle-boxes ofrolling stock when the train is in motion and discusses the forcesacting on the wheel-set when rolling stock moves along the trackcurves. The paper analyses scientific publications relevant tothe forces acting on the wheel-set of rolling stock and focuseson the axle-box heating process. The article also discusses theresults of theoretical studies on wheel-set forces that affect theheat exchange process of axle-boxes for a railway vehicle. Theresearch has determined a change in heating temperatures ofdifferent axle-boxes of rolling stock and reasons for their variationsand tendencies. The paper has estimated an effect of thetrain running along the track curves on the heating intensity ofthe axle-box. Finally, valid conclusions and recommendationshave been provided.

  7. Multi-axle dynamic steering system of truck-howitzer

    Institute of Scientific and Technical Information of China (English)

    Yanliang LI; Xiuhua GAO; Chunqiu ZHANG; Yubo SUN

    2008-01-01

    A two-degree-of-freedom (2-DOF) steering model of multi-axle vehicle was established. The steering center position, the relationship between the steering angle and the vehicle velocity, and the minimum turn radius were deduced on the basis of the proportional control with a zero sideslip angle. Results indicate that the system stability is decided by the vehicle barycenter position and the lateral stiffness of a tire. Under this control, the steady value of the lateral acceleration is obviously diminished and the yaw angular velocity changes little under any vehicle velocity. The system rapidly responds, the vehicle smoothly steers, and its handling stability is prominently improved.

  8. Impulsive Loading of Armour by High Explosive Squash Head Munition

    Directory of Open Access Journals (Sweden)

    P.U. Deshpande

    2003-10-01

    Full Text Available Results obtained by theoretical modelling studies involving classical stress-strain theories, duly validated by experimental investigation in understanding the mechanism of impulsive loading (scabbing and blast under dynamic and static conditions, are discussed. This concept has been used in designing a high explosive squash head ammunition being effective in defeating monolithic armour. Efforts have been made to carry out an in-depth study in understanding the mechanism of scabbing under static and dynamic (live firing conditions. For this purpose, a one-dimensional computer code has been used to predict the spread of explosive against time on the target. The simulations were carried out using a 2-D Lagrangian hydrodynamic code for scabbing effect. The blast effect that follows under static and dynamic conditions has also been studied. Blast parameters have been computed in terms of TNT equivalent and compared with experimental results. The events occurring during impulsive loading of 135 mm monolithic rolled homogenous armour have been illustrated.

  9. Role of AXL expression in non-small cell lung cancer.

    Science.gov (United States)

    Qu, Xiaohan; Liu, Jinlu; Zhong, Xinwen; Li, Xi; Zhang, Qigang

    2016-12-01

    The present study aimed to investigate the expression profile of AXL in non-small cell lung cancer (NSCLC) and its clinical significance. The current study included 257 NSCLC patients, tyrosine-protein kinase receptor UFO (AXL) expression in paired lung cancer and adjacent normal lung tissues of NSCLC patients were compared by immunohistochemistry, western blot analysis and quantitative polymerase chain reaction (qPCR). These methods were used to detect the expression of the AXL gene and protein in fresh tissues from 35 patients. Small interfering RNA (siRNA) was transfected into the H1299 lung cancer cell line to knock down AXL expression; the effects of AXL-siRNA on cell proliferation and migration were examined by MTT and Transwell migration assay, respectively. It was found that AXL staining density in lung cancer tissues was significantly increased compared with adjacent normal lung tissues (55.25 vs. 26.85%; P<0.01); and the expression level of AXL in NSCLC patients was significantly associated with the degree of tumor differentiation (P<0.01) and the clinical stage of disease (P<0.01). Western blotting and qPCR showed that AXL expression was significantly higher in cancer tissues compared with that in adjacent lung tissue (P<0.05). Additionally, the current study also showed that AXL-siRNA inhibited H1299 cell proliferation and migration in vitro. The present study demonstrates the association between increased expression of AXL in NSCLC and the low differentiation phenotype, and its effects on cell proliferation and migration, suggesting its potential clinical values for the prognosis of NSCLC.

  10. Levels of vibration transmitted to the operator of the tractor equipped with front axle suspension

    Directory of Open Access Journals (Sweden)

    Daniele Pochi

    2013-09-01

    Full Text Available In recent years the comfort and the preservation of the health of the operators became central issues in the evolution of agricultural machinery and led to the introduction of devices aimed at improving working conditions. Thereby, for instance, the presence of air conditioner, soundproof cab and driver seat suspension became normal on agricultural tractors. The vibrations are one of the most complex issues to deal with, being determined by the characteristics and interaction of elements such as tyres, axles, mainframe, cab and seat suspension. In this respect, manufacturers are trying to improve their products, even integrating these elements with new devices such as the suspension on the front axle of the tractor, aimed at reducing the level of vibrations during the transfers at high speed. One of these underwent tests at CRA-ING. Since its purpose is to reduce the level of vibration transmitted to the driver, their measurements in different points of the tractor and in different operating conditions, were compared in order to evaluate the effectiveness of the device, expressed as time of exposure. The suspension system of the front axle is designed to absorb the oscillations (especially pitching determined by irregularities in the road surface, allowing an increased control of the vehicle at high speed, as demonstrated by the test results and confirmed by the driving impressions outlined by the operator. The action of the device under these conditions results in an increase of the exposure time, important fact because of the relevance of the road transfer operations of tractors with mounted implements or trailers to tow and of the tendency to increase the speed limit for the road tractors (in Germany were brought to 50 km h–1 for several years. The action just described is less evident with increasing irregularity of the road surface and with the decrease of the travel speed. Nevertheless, in such conditions, the device appears to

  11. Design and engineering structure analysis on paddy-field chassis steering drive axle with standard all-wheel-drive%标准四驱水田自走底盘转向驱动桥设计与工程结构分析

    Institute of Scientific and Technical Information of China (English)

    刘宏新; 郑利双; 徐高伟; 王晨

    2015-01-01

    In the main grain crop production in China, comprehensive mechanization level for paddy field is the lowest. At the same time, there exists the“bottleneck”problem of“bottleneck”problem such as rice planting mechanization. In the case of transplanter, although we have grasped the core technology of key components, overall machinery can not be popularized and applied due to lack of the support of cost-effective chassis. At present, in Chinese market, most of chassis are imported from Japan and South Korea, which widely use hydraulic transmission and variable speed technology. Because paddy planting operation has the characteristics of stable load and constant speed, using hydraulic transmission and continuous variable device causes low efficiency and has no much practical significance, and meanwhile, the demand for the power increases from 9 to 13 and even 15 kw. Northeast Agricultural University has designed a standard all-wheel drive light paddy self-propelled chassis with diesel-power and mechanical transmission for this situation, whose most prominent shape feature is that four wheels have same size and the front axle is different from any existing paddy field chassis structure. The chassis has the advantages of high transmission efficiency, large torque reserve, anti-sink capacity, dynamic stabilization, and good performance of crossing the earth bank between the paddy fields. As a transmission part, steering drive axle not only is a carrier installed, but also needs to bear the weight of chassis and the effect of impulsive load, and have the function of deflection wheel, and hence its structure is more complex than the traditional shell. The operating environment of paddy field chassis is harsher than general vehicle, which has stricter requirement of sludge, subsidence, bank and over load on axle. So, engineering analysis of structural design process is particularly important, however, conventional theoretical analysis and calculation method can not

  12. Application of high-turning bowed compressor stator to redesign of highly loaded fan stage

    Institute of Scientific and Technical Information of China (English)

    Shaobin LI; Jiexian SU; Zhongqi WANG

    2008-01-01

    A redesign of a highly loaded fan stage by using high-turning bowed compressor stator was conducted. The original tandem stator was replaced by the highly loaded bowed stator which was applicable to highly sub-sonic flow conditions. 3D contouring technique and local modification of blade were applied to the design of the bowed blade in order to improve the aerodynamic per-formance and the matching of the rotor and stator blade rows. Performance curves at different rotating speeds and performances at different operating points for both the original fan stage and redesigned fan stage were obtained by numerical simulations. The results show that the highly loaded bowed stator can be used not only to improve the structure and the aerodynamic performances at various operating points of the compressor stage but also to pro-vide high performances at off-design conditions. It is believed that the highly loaded bowed stator can advance the design of high-performance compressor.

  13. A Comparison of Increases in Volume Load Over 8 Weeks of Low-Versus High-Load Resistance Training

    Directory of Open Access Journals (Sweden)

    Schoenfeld

    2016-01-01

    Full Text Available Background It has been hypothesized that the ability to increase volume load (VL via a progressive increase in the magnitude of load for a given exercise within a given repetition range could enhance the adaptive response to resistance training. Objectives The purpose of this study was to compare changes in volume load (VL over eight weeks of resistance training (RT in high-versus low-load protocols. Materials and Methods Eighteen well-trained men were matched according to baseline strength were randomly assigned to either a low-load RT (LOW, n = 9 where 25 - 35 repetitions were performed per exercise, or a high-load RT (HIGH, n = 9 where 8 - 12 repetitions were performed per exercise. Both groups performed three sets of seven exercises for all major muscles three times per week on non-consecutive days. Results After adjusting for the pre-test scores, there was a significant difference between the two intervention groups on post-intervention total VL with a very large effect size (F (1, 15 = 16.598, P = .001, ηp2 = .525. There was a significant relationship between pre-intervention and post-intervention total VL (F (1, 15 = 32.048, P < .0001, ηp2 = .681 in which the pre-test scores explained 68% of the variance in the post-test scores. Conclusions This study indicates that low-load RT results in greater accumulations in VL compared to high-load RT over the course of 8 weeks of training.

  14. Vibration levels on rear and front axles of a tractor in agricultural operations - doi: 10.4025/actascitechnol.v36i1.18170

    Directory of Open Access Journals (Sweden)

    Geice Paula Villibor

    2014-01-01

    Full Text Available Excessive vibrations in agricultural tractors can contribute with mechanical failures and subject the operator to discomfort. This work evaluated the vibration levels on rear and front axles of an agricultural tractor working at different forward speeds and wheel drive conditions in plowing and harrowing operations. Field tests were carried out in a completely randomized design in a factorial arrangement 3 x 2 (forward travel speeds x front-wheel-assist enable or disable, with three replications. Tractor vibration was measured using two single axis accelerometers fixed above the rear and front axles. The actual forward speed of the tractor was obtained by means of ultrasonic radar and the angular velocity of the wheels was measured with magnetic transducers. The drawbar force to pull the disc harrow was obtained by a load cell. The results showed that the vibration levels observed for the plowing operation were higher than observed for the harrowing operation. When the front-wheel-assist (FWA was enabled there was a reduction in vertical vibration levels of the tractor axles. The highest vibration levels were observed in the frequency range of 2 to 4Hz for the both soil tillage operations evaluated

  15. Rectangular Dielectric-loaded Structures for Achieving High Acceleration Gradients

    Science.gov (United States)

    Wang, Changbiao; Yakovlev, V. P.; Marshall, T. C.; LaPointe, M. A.; Hirshfield, J. L.

    2006-11-01

    Rectangular dielectric-loaded structures are described that may sustain higher acceleration gradients than conventional all-metal structures with similar apertures. One structure is a test cavity designed to ascertain the breakdown limits of dielectrics, while a second structure could be the basis for a two-beam accelerator. CVD diamond is an attractive dielectric for a high-gradient structure, since the published DC breakdown limit for CVD diamond is ˜ 2 GV/m, although the limit has never been determined for RF fields. Here we present a design of a diamond-lined test cavity to measure the breakdown limit. The designed cavity operates at 34 GHz, where with 10-MW input power it is expected to produce an ˜800 MV/m field on the diamond surface—provided breakdown is avoided. The two channel rectangular dielectric-loaded waveguide could be a two-beam accelerator structure, in which a drive beam is in one channel and an accelerated beam is in the other. The RF power produced by drive bunches in the drive channel is continuously coupled to the acceleration channel. The ratio of fields in the channels (transformer ratio) for the operating mode can be designed by adjusting the dimensions of the structure. An example of the two-channel structure is described, in which a train of five 3-nC drive bunches excites wake fields in the accelerator channel of up to 1.3 GV/m with a transformer ratio of 10 for the design mode.

  16. Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias.

    Science.gov (United States)

    Neubauer, A; Burchert, A; Maiwald, C; Gruss, H J; Serke, S; Huhn, D; Wittig, B; Liu, E

    1997-03-01

    Receptor tyrosine kinases (RTK) play an important role in the signal transduction of normal and malignant cells. There are different families of RTKs which are mainly characterized by differences in the ligang-binding extracellular domains. Axl (or UFO/Ark) is the first member of a new class of RTK with two fibronectin type III domains and two immunoglobulin-like domains present at the extracellular domain. The axl-gene has been isolated by means of gene transfection studies using DNA of patients with chronic myelogeneous leukemia. For a previous and the present study, we used a sensitive reverse-transcriptase polymerase chain reaction assay to detect axl's mRNA in cells from normal and malignant hematopoietic tissue. Axl's mRNA expression was mainly detected in myelo-monocytic cells, whereas much weaker transcription was seen in lymphatic cells and in lymphatic leukemias. In normal bone marrow, axl was heavily transcribed in marrow stromal cells. Further, we analysed Axl protein expression using monoclonal antibody M50 in peripheral stem cell harvests; in most harvests, no co-expression of CD34 and Axl was detected. However, in one patient with AML in complete remission, Axl was co-expressed on 80% of the CD34-positive population. These data show that axl is preferentially expressed in monocytes and stromal cells. Furthermore, a fraction of CD34-positive progenitor cells may express Axl. The exact mechanism for transformation of myeloid progenitor cells through Axl, however, remains to be determined.

  17. Gas6/Axl pathway promotes tumor invasion through the transcriptional activation of Slug in hepatocellular carcinoma.

    Science.gov (United States)

    Lee, Hsin-Jung; Jeng, Yung-Ming; Chen, Yu-Ling; Chung, Ling; Yuan, Ray-Hwang

    2014-04-01

    Hepatocellular carcinoma (HCC) is one of the most common fatal cancers worldwide. Other than the sorafenib treatment, no effective systemic therapy has been available thus far. Most targets in molecularly targeted therapy for cancer are receptor tyrosine kinases (RTKs). Therefore, identifying activated RTKs in HCC is critical for developing new molecularly targeted therapies. Using a phospho-RTK array, we found that Axl is one of the most frequently activated RTKs in liver cancer cell lines. The knockdown of Axl by RNA interference significantly reduced cell migration and invasion in the HCC cell lines HA22T and Mahlavu. Stimulation of HCC cell lines by Axl ligand growth arrest-specific 6 (Gas6) enhanced cell migration and invasion. The Gas6/Axl pathway enhanced the expression of the epithelial-mesenchymal transition-inducing transcription factor Slug, which is essential for the invasion-promoting activity of Axl. Treating HCC cells with the Axl inhibitor bosutinib suppressed Slug expression and decreased the invasiveness of HCC cell lines. These findings indicate that Gas6/Axl regulates tumor invasion through the transcriptional activation of Slug.

  18. Microfluidic generation of droplets with a high loading of nanoparticles.

    Science.gov (United States)

    Wan, Jiandi; Shi, Lei; Benson, Bryan; Bruzek, Matthew J; Anthony, John E; Sinko, Patrick J; Prudhomme, Robert K; Stone, Howard A

    2012-09-18

    Microfluidic approaches for controlled generation of colloidal clusters, for example, via encapsulation of colloidal particles in droplets, have been used for the synthesis of functional materials including drug delivery carriers. Most of the studies, however, use a low concentration of an original colloidal suspension (microfluidic approaches for directly making droplets with moderate (10-25 wt %) and high (>60 wt %) particle concentrations. Three types of microfluidic devices, PDMS flow-focusing, PDMS T-junction, and microcapillary devices, are investigated for direct encapsulation of a high concentration of polystyrene (PS) nanoparticles in droplets. In particular, it is shown that PDMS devices fabricated by soft lithography can generate droplets from a 25 wt % PS suspension, whereas microcapillary devices made from glass capillary tubes are able to produce droplets from a 67 wt % PS nanoparticle suspension. When the PS concentration is between 0.6 and 25 wt %, the size of the droplets is found to change with the oil-to-water flow rate ratio and is independent of the concentration of particles in the initial suspensions. Drop sizes from ~12 to 40 μm are made using flow rate ratios Q(oil)/Q(water) from 20 to 1, respectively, with either of the PDMS devices. However, clogging occurs in PDMS devices at high PS concentrations (>25 wt %) arising from interactions between the PS colloids and the surface of PDMS devices. Glass microcapillary devices, on the other hand, are resistant to clogging and can produce droplets continuously even when the concentration of PS nanoparticles reaches 67 wt %. We believe that our findings indicate useful approaches and guidelines for the controlled generation of emulsions filled with a high loading of nanoparticles, which are useful for drug delivery applications.

  19. 1580热轧R2粗轧机主传动十字轴失效分析%Invalidation analysis for main driving cross axle of R2 roughing mill in 1580 hot rolling mill

    Institute of Scientific and Technical Information of China (English)

    廖永锋

    2011-01-01

    对宝钢1580热轧R2粗轧机主传动十字轴的失效原因进行了分析,指出该十字轴主要是在1.5倍额定负荷以上的工况条件下产生接触疲劳破坏,并提出了对十字轴表面重新加工处理,使其恢复表面硬度和粗糙度,重新单配轴承的修复方案,延长了十字轴的使用寿命.%The invalidation reason of R2 main driving cross axle in Baosteel 1580 hot rolling mill is analyzed.It is pointed out that the contact fatigue failure of the cross axle is due to more than 1.5 times of nominal load under working condition.An approach to treat the damaged working surface of the cross axle, and recover its surface stiffness and roughness, then make up bearing is put forward, and that service life of cross axle is prolonged.

  20. Participation of Flexible Loads in Load Frequency Control to Support High Wind Penetration

    DEFF Research Database (Denmark)

    uslu, umur; Zhang, Boyang; Pillai, Jayakrishnan Radhakrishna;

    2016-01-01

    The increasing amount of fluctuating wind power penetration in power systems presents many challenges to its operation and control. The new wind power plants are replacing many of the conventional large power plants that ensure power balancing and ancillary services for stable and reliable...... operation of the grid. Therefore, new solutions for power balancing reserves have to be explored and utilized by the grid utilities. To meet these challenges, large sizable loads like alkaline electrolysers, heat pumps and electric vehicles which are gaining popularity can provide system support to the grid...... through their inherent flexibility and energy storage characteristics. This paper investigates the possibilities and potential of such flexible loads to participate in power system frequency regulation in a wind dominated power system. The results show that these consumption units provide better...

  1. MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer

    Directory of Open Access Journals (Sweden)

    Wanqin Wang

    2017-01-01

    Full Text Available AXL receptor tyrosine kinase is overexpressed in a number of solid tumor types including triple-negative breast cancer (TNBC. AXL is considered an important regulator of epithelial-to-mesenchymal transition (EMT and a potential therapeutic target for TNBC. In this work, we used microPET/CT with 64Cu-labeled anti-human AXL antibody (64Cu-anti-hAXL to noninvasively interrogate the degradation of AXL in vivo in response to 17-allylamino-17-demethoxygeldanamycin (17-AAG, a potent inhibitor of HSP90. 17-AAG treatment caused significant decline in AXL expression in orthotopic TNBC MDA-MB-231 tumors, inhibited EMT, and delayed tumor growth in vivo, resulting in significant reduction in tumor uptake of 64Cu-anti-hAXL as clearly visualized by microPET/CT. Our data indicate that 64Cu-anti-hAXL can be useful for monitoring anti-AXL therapies and for assessing inhibition of HSP90 molecular chaperone using AXL as a molecular surrogate.

  2. Cyclic Fracture Toughness of Railway Axle and Mechanisms of its Fatigue Fracture

    Directory of Open Access Journals (Sweden)

    Sorochak Andriy

    2015-06-01

    Full Text Available The main regularities in fatigue fracture of the railway axle material - the OSL steel - are found in this paper. Micromechanisms of fatigue crack propagation are described and systematized, and a physical-mechanical interpretation of the relief morphology at different stages of crack propagation is proposed for fatigue cracks in specimens cut out of the surface, internal and central layers of the axle.

  3. AXL as a modulator of sunitinib response in glioblastoma cell lines

    OpenAIRE

    Martinho, Olga Catarina Lopes; Zucca, Luís Eduardo; Reis,R.M.

    2015-01-01

    Receptor tyrosine kinase (RTK) targeted therapy has been explored for glioblastoma treatment. However, it is unclear which RTK inhibitors are the most effective and there are no predictive biomarkers available. We recently identified the RTK AXL as a putative target for the pan-RTK inhibitors cediranib and sunitinib, which are under clinical trials for glioblastoma patients. Here, we provide evidence that AXL activity can modulate sunitinib response in glioblastoma cell lines. We found that A...

  4. Expression of Axl and its prognostic significance in human breast cancer

    OpenAIRE

    Jin, Gaoyuan; Wang, Zhenzhen; Wang, Jianguang; Zhang, Like; CHEN Yanbin; Yuan, Pengfei; Liu, Dechun

    2016-01-01

    Breast cancer is the most common malignant cancer and second leading cause of cancer-related death among women, and its prevalence continues to increase. Axl overexpression has been identified in the many types of human cancer, and it has been demonstrated to participate in signaling pathways related to carcinogenesis and cancer development. In the present study, Axl expression was examined by performing immunohistochemical staining in 60 breast cancer tumors and 40 benign breast lesions (25 ...

  5. Non-intrusive schemes for speed and axle identification in bridge-weigh-in-motion systems

    Science.gov (United States)

    Kalhori, Hamed; Makki Alamdari, Mehrisadat; Zhu, Xinqun; Samali, Bijan; Mustapha, Samir

    2017-02-01

    Bridge weigh-in-motion (BWIM) is an approach through which the axle and gross weight of trucks travelling at normal highway speed are identified using the response of an instrumented bridge. The vehicle speed, the number of axles, and the axle spacing are crucial parameters, and are required to be determined in the majority of BWIM algorithms. Nothing-on-the-road (NOR) strategy suggests using the strain signals measured at some particular positions underneath the deck or girders of a bridge to obtain this information. The objective of this research is to present a concise overview of the challenges of the current non-intrusive schemes for speed and axle determination through bending-strain and shear-strain based approaches. The problem associated with the global bending-strain responses measured at quarter points of span is discussed and a new sensor arrangement is proposed as an alternative. As for measurement of local responses rather than the global responses, the advantage of shear strains over bending strains is presented. However, it is illustrated that shear strains at quarter points of span can only provide accurate speed estimation but fail to detect the correct number of axles. As a remedy, it is demonstrated that, even for closely-spaced axles, the shear strain at the beginning of the bridge is capable of reliably identifying the number of axles. In order to provide a fully automated speed and axle identification system, appropriate signal processing including low-pass filtering and wavelet transforms are applied to the raw time signals. As case studies, the results of experimental testing in laboratory and on a real bridge are presented.

  6. Sex differences in verbal working memory performance emerge at very high loads of common neuroimaging tasks.

    Science.gov (United States)

    Reed, Jessica L; Gallagher, Natalie M; Sullivan, Marie; Callicott, Joseph H; Green, Adam E

    2017-04-01

    Working memory (WM) supports a broad range of intelligent cognition and has been the subject of rich cognitive and neural characterization. However, the highest ranges of WM have not been fully characterized, especially for verbal information. Tasks developed to test multiple levels of WM demand (load) currently predominate brain-based WM research. These tasks are typically used at loads that allow most healthy participants to perform well, which facilitates neuroimaging data collection. Critically, however, high performance at lower loads may obscure differences that emerge at higher loads. A key question not yet addressed at high loads concerns the effect of sex. Thoroughgoing investigation of high-load verbal WM is thus timely to test for potential hidden effects, and to provide behavioral context for effects of sex observed in WM-related brain structure and function. We tested 111 young adults, matched on genotype for the WM-associated COMT-Val(108/158)Met polymorphism, on three classic WM tasks using verbal information. Each task was tested at four WM loads, including higher loads than those used in previous studies of sex differences. All tasks loaded on a single factor, enabling comparison of verbal WM ability at a construct level. Results indicated sex effects at high loads across tasks and within each task, such that males had higher accuracy, even among groups that were matched for performance at lower loads.

  7. Participation of Flexible Loads in Load Frequency Control to Support High Wind Penetration

    DEFF Research Database (Denmark)

    Uslu, Umur; Zhang, Boyang; Pillai, Jayakrishnan Radhakrishna;

    2016-01-01

    The increasing amount of fluctuating wind power penetration in power systems presents many challenges to its operation and control. The new wind power plants are replacing many of the conventional large power plants that ensure power balancing and ancillary services for stable and reliable...... operation of the grid. Therefore, new solutions for power balancing reserves have to be explored and utilized by the grid utilities. To meet these challenges, large sizable loads like alkaline electrolysers, heat pumps and electric vehicles which are gaining popularity can provide system support to the grid...... performance for balancing the power than the conventional generation reserves....

  8. Novel wavelet threshold denoising method in axle press-fit zone ultrasonic detection

    Science.gov (United States)

    Peng, Chaoyong; Gao, Xiaorong; Peng, Jianping; Wang, Ai

    2017-02-01

    Axles are important part of railway locomotives and vehicles. Periodic ultrasonic inspection of axles can effectively detect and monitor axle fatigue cracks. However, in the axle press-fit zone, the complex interface contact condition reduces the signal-noise ratio (SNR). Therefore, the probability of false positives and false negatives increases. In this work, a novel wavelet threshold function is created to remove noise and suppress press-fit interface echoes in axle ultrasonic defect detection. The novel wavelet threshold function with two variables is designed to ensure the precision of optimum searching process. Based on the positive correlation between the correlation coefficient and SNR and with the experiment phenomenon that the defect and the press-fit interface echo have different axle-circumferential correlation characteristics, a discrete optimum searching process for two undetermined variables in novel wavelet threshold function is conducted. The performance of the proposed method is assessed by comparing it with traditional threshold methods using real data. The statistic results of the amplitude and the peak SNR of defect echoes show that the proposed wavelet threshold denoising method not only maintains the amplitude of defect echoes but also has a higher peak SNR.

  9. Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.

    Science.gov (United States)

    Li, Nan; Liu, Zhenghui; Zhang, Yue; Chen, Qiaoyuan; Liu, Peng; Cheng, C Yan; Lee, Will M; Chen, Yongmei; Han, Daishu

    2015-03-01

    The mammalian testis is an immunoprivileged organ where male germ cell autoantigens are immunologically ignored. Both systemic immune tolerance to autoantigens and local immunosuppressive milieu contribute to the testicular immune privilege. Testicular immunosuppression has been intensively studied, but information on systemic immune tolerance to autoantigens is lacking. In the present study, we aimed to determine the role of Axl and Mer receptor tyrosine kinases in maintaining the systemic tolerance to male germ cell antigens using the experimental autoimmune orchitis (EAO) model. Axl and Mer double-knockout (Axl(-/-)Mer(-/-)) mice developed evident EAO after a single immunization with germ cell homogenates emulsified with complete Freund's adjuvant. EAO was characterized by the accumulation of macrophages and T lymphocytes in the testis. Damage to the seminiferous epithelium was also observed. EAO induction was associated with pro-inflammatory cytokine upregulation in the testes, impaired permeability of the blood-testis barrier and generation of autoantibodies against germ cell antigens in Axl(-/-)Mer(-/-) mice. Immunization also induced mild EAO in Axl or Mer single-gene-knockout mice. By contrast, a single immunization failed to induce EAO in wild-type mice. The results indicate that Axl and Mer receptors cooperatively regulate the systemic immune tolerance to male germ cell antigens.

  10. Dynamics of Drive Axle System with Effects of Input Torque%输入转矩对驱动桥系统动力学特性的影响

    Institute of Scientific and Technical Information of China (English)

    周驰; 王琪; 丁炜琦; 桂良进; 范子杰

    2016-01-01

    Driveline and housings are connected by roller bearings. The bearing stiffness is nonlinear and coupling in all directions and changes with the input torque of drive axle, which leads to variation in the drive axle system dynamics. Based on the nonlinear bearing theory, the finite element method and modal synthesis method, a drive axle final drive gear transmission system dynamic model with final drive gear transmission assembly, differential gear transmission assembly, hub assembly and housings etc. is built. According to the magnitude of the input torque of the pinion shaft, the load cases are set out into light load, medium load and heavy load. Nonlinear bearing stiffness is calculated corresponding to each load case. The axial stiffness and radial stiffness of final drive roller bearing with load change characteristics are analyzed. Dynamic analysis of the whole drive axle system to a unit harmonic transmission error at the hypoid gear mesh is performed in the case of different input torques. The influence of the input torque on the drive axle is researched. The frequency response characteristics of final drive hypoid gear dynamic meshing force is analyzed when the drive axle system works in different load cases. The results show that the drive axle system dynamics change with the size of the input torque with a certain regularity, and can guide the design of the vibration and noise reduction of drive axle system in order to avoid dangerous conditions effectively.%在驱动桥系统中,滚子轴承是连接轴系与壳体的关键部件,其刚度具有各向耦合性和非线性特性,且与输入转矩有关。为准确高效地分析输入转矩对驱动桥系统动力学特性的影响,基于非线性轴承理论、有限元法和模态综合方法,建立包含主减速器总成、差速器总成、轮毂总成和桥壳等部件的完整驱动桥系统动力学分析模型,根据输入转矩大小的不同,定义轻载、中载和重载三种

  11. Distribution of background equivalent static wind load on high-rise buildings

    Institute of Scientific and Technical Information of China (English)

    Jianguo ZHANG; Ming GU

    2009-01-01

    In this paper, the along-wind and cross-wind fluctuating load distributions along the height of high-rise buildings and their correlations are obtained through simultaneous pressure measurements in a wind tunnel.Some typical methods proposed in some relative litera-tures, i.e., load-response correlation (LRC), and quasi-mean load (QML) and gust load envelope (GLE) methods,are verified in terms of their accuracy in describing the background equivalent static wind load distribution on high-rise buildings. Based on the results, formulae of the distribution of background equivalent static load on high-rise buildings with typical shapes are put forward. It is shown that these formulae are of high accuracy and practical use.

  12. Muscular adaptations in low- versus high-load resistance training: A meta-analysis.

    Science.gov (United States)

    Schoenfeld, Brad J; Wilson, Jacob M; Lowery, Ryan P; Krieger, James W

    2016-01-01

    There has been much debate as to optimal loading strategies for maximising the adaptive response to resistance exercise. The purpose of this paper therefore was to conduct a meta-analysis of randomised controlled trials to compare the effects of low-load (≤60% 1 repetition maximum [RM]) versus high-load (≥65% 1 RM) training in enhancing post-exercise muscular adaptations. The strength analysis comprised 251 subjects and 32 effect sizes (ESs), nested within 20 treatment groups and 9 studies. The hypertrophy analysis comprised 191 subjects and 34 ESs, nested with 17 treatment groups and 8 studies. There was a trend for strength outcomes to be greater with high loads compared to low loads (difference = 1.07 ± 0.60; CI: -0.18, 2.32; p = 0.09). The mean ES for low loads was 1.23 ± 0.43 (CI: 0.32, 2.13). The mean ES for high loads was 2.30 ± 0.43 (CI: 1.41, 3.19). There was a trend for hypertrophy outcomes to be greater with high loads compared to low loads (difference = 0.43 ± 0.24; CI: -0.05, 0.92; p = 0.076). The mean ES for low loads was 0.39 ± 0.17 (CI: 0.05, 0.73). The mean ES for high loads was 0.82 ± 0.17 (CI: 0.49, 1.16). In conclusion, training with loads ≤50% 1 RM was found to promote substantial increases in muscle strength and hypertrophy in untrained individuals, but a trend was noted for superiority of heavy loading with respect to these outcome measures with null findings likely attributed to a relatively small number of studies on the topic.

  13. Algorithm of dynamic stabilization system for a car 4x4 with a link rear axle

    Directory of Open Access Journals (Sweden)

    M. M. Jileikin

    2014-01-01

    Full Text Available The slow development of active safety systems of the automobile all-wheel drive vehicles is the cause of lack of researches in the field of power distribution under the specific conditions of movement. The purpose of work is to develop methods to control a curvilinear motion of 4x4 cars with a link to the rear axle that provides the increase in directional and trajectory stability of the car. The paper analyses the known methods to increase wheeled vehicles movement stability. It also offers a method for power flow redistribution in the transmission of the car 4x4 with a link to the rear axle, providing the increase in directional and trajectory stability of the car.To study the performance and effectiveness of the proposed method a mathematical model of the moving car 4x4 with a link to the rear axle is developed. Simulation methods allowed us to establish the following:1. for car 4x4 with redistribution of torque between the driving axles in the range of 100:0 - 50:50 and with redistribution of torque between the wheels of the rear axle in the range of 0:100 the most effective are the stabilization algorithms used in combination “Lowing power consumption of the engine +Creation of stabilizing the moment due to the redistribution of torque on different wheels", providing the increase in directional and trajectory stability by 12...93%;2. for car 4x4 with redistribution of torque between the driving axles in the range 100:0 - 0:100 and with redistribution of torque between the wheels of the rear axle in the range of 0:100 the best option is a combination of algorithms "Lowing power consumption of the engine + Creation of stabilizing moment due to redistribution of torques on different wheels", providing the increase in directional and trajectory stability by 27...93%.A comparative analysis of algorithms efficiency of dynamic stabilization system operation for two-axle wheeled vehicles depending on the torque redistribution between the driving

  14. LOADS INFLUENCE ANALYSIS ON NOVEL HIGH PRECISION FLEXURE PARALLEL POSITIONER

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A large workspace flexure parallel positioner system is developed, which can attain sub-micron scale accuracy over cubic centimeter motion range for utilizing novel wide-range flexure hinges instead of the conventional mechanism joints. Flexure hinges eliminate backlash and friction, but on the other hand their deformation caused by initial loads influences the positioning accuracy greatly, so discussions about loads' influence analysis on this flexure parallel positioner is very necessary. The stiffness model of the whole mechanism is presented via stiffness assembly method based on the stiffness model of individual flexure hinge. And the analysis results are validated by the finite element analysis (FEA) simulation and experiment tests, which provide essential data to the practical application of this positioner system.

  15. Response of reinforced concrete and corrugated steel pipes to surface load

    Science.gov (United States)

    Lay, Geoff R.

    Full-scale simulated live load tests were conducted in a controlled laboratory setting using a single-axle frame on 600-mm-inner-diameter reinforced concrete pipe (RCP) and corrugated steel pipe (CSP) when buried in dense, well-graded sand and gravel. Measurements of the RCP at nominal and working forces and beyond are reported for 0.3, 0.6 and 0.9 m of soil cover above the pipe crown. The RCP experienced no cracking when buried at 0.3 m under nominal and working CL-625 and CL-800 single-axle design loads. At these loads, the vertical contraction of the pipe diameter was less than 0.08 and 0.10 mm and the largest tensile strains in the pipe were 75 and 100 muepsilon (50-60% of the cracking strain), respectively. A 0.15 (+/-0.05)-mm-wide axial crack developed at the inner crown in the presence of a 6 kNm/m circumferential bending moment (70% of the theoretical ultimate moment capacity) at the fully factored CL-625 load. This crack did not propagate or widen from 3 series of cyclic load-unload tests. At 1300 kN of applied load the change in pipe diameter was less than 3.5 mm. Increasing soil cover from 0.3 to 0.6 to 0.9 m reduced the circumferential crown bending moment from 6.0 to 3.9 to 2.1 kNm/m, respectively, at 400 kN of axle load. A 1.6- and a 2.8-mm-thick CSP were also subjected to axle loading. No yielding or limit states occurred in the 1.6-mm-thick CSP when buried 0.9-m-deep. However, at 0.6 m of cover a 300 kN axle load caused local yielding at the pipe crown. Increasing soil cover from 0.6 to 0.9 m decreased the vertical diameter change from -3.0 to -1.2 mm and the crown bending moment from 0.7 to 0.2 kNm/m (75% and 20% of the yield moment), respectively, at a 250 kN axle load. Deflections of the thicker CSP were less than the thinner pipe below the CL-625 single-axle load, however further increases in applied load produced a greater response in the thicker pipe, likely due to a haunch support issue. Shallow axle loading produced a greater 3-dimensional

  16. Review of 20 years research in fatigue of high pressure loaded components

    Energy Technology Data Exchange (ETDEWEB)

    Thumser, Rayk [Bauhaus Univ. Weimar (Germany). Materialforschungs- und -pruefanstalt; Scheibe, Wolfgang

    2011-07-01

    This paper gives an overview of the research in fatigue of high pressure loaded components. In the last 20 years the main research was carried out in Germany. This research was mainly driven by the fatigue requirements for high pressure loaded Diesel engine injection parts as common rails, injectors and pipes. (orig.)

  17. Gearbox Reliability Collaborative Investigation of High-Speed-Shaft Bearing Loads

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jonathan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Guo, Yi [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-06-01

    The loads and contact stresses in the bearings of the high speed shaft section of the Gearbox Reliability Collaborative gearbox are examined in this paper. The loads were measured though strain gauges installed on the bearing outer races during dynamometer testing of the gearbox. Loads and stresses were also predicted with a simple analytical model and higher-fidelity commercial models. The experimental data compared favorably to each model, and bearing stresses were below thresholds for contact fatigue and axial cracking.

  18. Potent engineered PLGA nanoparticles by virtue of exceptionally high chemotherapeutic loadings.

    Science.gov (United States)

    Enlow, Elizabeth M; Luft, J Christopher; Napier, Mary E; DeSimone, Joseph M

    2011-02-01

    Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings and the clinical formulation of docetaxel, Taxotere.

  19. Ride comfort optimization of a multi-axle heavy motorized wheel dump truck based on virtual and real prototype experiment integrated Kriging model

    Directory of Open Access Journals (Sweden)

    Bian Gong

    2015-06-01

    Full Text Available The optimization of hydro-pneumatic suspension parameters of a multi-axle heavy motorized wheel dump truck is carried out based on virtual and real prototype experiment integrated Kriging model in this article. The root mean square of vertical vibration acceleration, in the center of sprung mass, is assigned as the optimization objective. The constraints are the natural frequency, the working stroke, and the dynamic load of wheels. The suspension structure for the truck is the adjustable hydro-pneumatic suspension with ideal vehicle nonlinear characteristics, integrated with elastic and damping elements. Also, the hydraulic systems of two adjacent hydro-pneumatic suspension are interconnected. Considering the high complexity of the engineering model, a novel kind of meta-model called virtual and real prototype experiment integrated Kriging is proposed in this article. The interpolation principle and the construction of virtual and real prototype experiment integrated Kriging model were elucidated. Being different from traditional Kriging, virtual and real prototype experiment integrated Kriging combines the respective advantages of actual test and Computer Aided Engineering simulation. Based on the virtual and real prototype experiment integrated Kriging model, the optimization results, obtained by experimental verification, showed significant improvement in the ride comfort by 12.48% for front suspension and 11.79% for rear suspension. Compared with traditional Kriging, the optimization effect was improved by 3.05% and 3.38% respectively. Virtual and real prototype experiment integrated Kriging provides an effective way to approach the optimal solution for the optimization of high-complexity engineering problems.

  20. Progressive high-load strength training compared with general low-load exercises in patients with rotator cuff tendinopathy

    DEFF Research Database (Denmark)

    Ingwersen, Kim G; Christensen, Robin; Sørensen, Lilli

    2015-01-01

    subgroups of SIS and have often had methodological flaws, making it difficult to specifically design target treatment for patients diagnosed with SIS. Therefore, it was considered important to focus on a subgroup such as tendinopathy, with a specific tailored intervention strategy based on evidence from...... of this trial is to compare the efficacy of progressive high-load exercises with traditional low-load exercises in patients with rotator cuff tendinopathy. Methods/Design: The current study is a randomised, participant- and assessor-blinded, controlled multicentre trial. A total of 260 patients with rotator...... home-based exercises three times a week. The primary outcome measure will be change from baseline to 12 weeks in the patient-reported outcome Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire. Discussion: Previous studies of exercise treatment for SIS have not differentiated between...

  1. Three Months of Progressive High-Load Versus Traditional Low-Load Strength Training Among Patients With Rotator Cuff Tendinopathy

    DEFF Research Database (Denmark)

    Ingwersen, Kim Gordon; Jensen, Steen Lund; Sørensen, Lilli

    2017-01-01

    BACKGROUND: Progressive high-load exercise (PHLE) has led to positive clinical results in patients with patellar and Achilles tendinopathy. However, its effects on rotator cuff tendinopathy still need to be investigated. PURPOSE: To assess the clinical effects of PHLE versus low-load exercise (LLE......) among patients with rotator cuff tendinopathy. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: Patients with rotator cuff tendinopathy were recruited and randomized to 12 weeks of PHLE or LLE, stratified for concomitant administration of corticosteroid injection. The primary...... benefit from PHLE over traditional LLE among patients with rotator cuff tendinopathy. Further investigation of the possible interaction between exercise type and corticosteroid injection is needed to establish optimal and potentially synergistic combinations of these 2 factors. REGISTRATION: NCT01984203...

  2. Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE.

    Science.gov (United States)

    Orme, Jacob J; Du, Yong; Vanarsa, Kamala; Mayeux, Jessica; Li, Li; Mutwally, Azza; Arriens, Cristina; Min, Soyoun; Hutcheson, Jack; Davis, Laurie S; Chong, Benjamin F; Satterthwaite, Anne B; Wu, Tianfu; Mohan, Chandra

    2016-08-01

    Systemic lupus erythematosus (SLE) is characterized by antibody-mediated chronic inflammation in the kidney, lung, skin, and other organs to cause inflammation and damage. Several inflammatory pathways are dysregulated in SLE, and understanding these pathways may improve diagnosis and treatment. In one such pathway, Axl tyrosine kinase receptor responds to Gas6 ligand to block inflammation in leukocytes. A soluble form of the Axl receptor ectodomain (sAxl) is elevated in serum from patients with SLE and lupus-prone mice. We hypothesized that sAxl in SLE serum originates from the surface of leukocytes and that the loss of leukocyte Axl contributes to the disease. We determined that macrophages and B cells are a source of sAxl in SLE and in lupus-prone mice. Shedding of the Axl ectodomain from the leukocytes of lupus-prone mice is mediated by the matrix metalloproteases ADAM10 and TACE (ADAM17). Loss of Axl from lupus-prone macrophages renders them unresponsive to Gas6-induced anti-inflammatory signaling in vitro. This phenotype is rescued by combined ADAM10/TACE inhibition. Mice with Axl-deficient macrophages develop worse disease than controls when challenged with anti-glomerular basement membrane (anti-GBM) sera in an induced model of nephritis. ADAM10 and TACE also mediate human SLE PBMC Axl cleavage. Collectively, these studies indicate that increased metalloprotease-mediated cleavage of leukocyte Axl may contribute to end organ disease in lupus. They further suggest dual ADAM10/TACE inhibition as a potential therapeutic modality in SLE.

  3. Electronic system for high power load control. [solar arrays

    Science.gov (United States)

    Miller, E. L. (Inventor)

    1980-01-01

    Parallel current paths are divided into two groups, with control devices in the current paths of one group each having a current limiting resistor, and the control devices in the other group each having no limiting resistor, so that when the control devices of the second group are turned fully on, a short circuit is achieved by the arrangement of parallel current paths. Separate but coordinated control signals are provided to turn on the control devices of the first group and increase their conduction toward saturation as a function of control input, and when fully on, or shortly before, to turn on the control devices of the second group and increase their conduction toward saturation as a function of the control input as that input continues to increase. Electronic means may be used to generate signals. The system may be used for 1-V characteristic measurements of solar arrays as well as for other load control purposes.

  4. Maximum Likelihood Estimation of Time-Varying Loadings in High-Dimensional Factor Models

    DEFF Research Database (Denmark)

    Mikkelsen, Jakob Guldbæk; Hillebrand, Eric; Urga, Giovanni

    In this paper, we develop a maximum likelihood estimator of time-varying loadings in high-dimensional factor models. We specify the loadings to evolve as stationary vector autoregressions (VAR) and show that consistent estimates of the loadings parameters can be obtained by a two-step maximum...... likelihood estimation procedure. In the first step, principal components are extracted from the data to form factor estimates. In the second step, the parameters of the loadings VARs are estimated as a set of univariate regression models with time-varying coefficients. We document the finite...

  5. Fault Diagnosis of Train Axle Box Bearing Based on Multifeature Parameters

    Directory of Open Access Journals (Sweden)

    Xiaofeng Li

    2015-01-01

    Full Text Available Failure of the train axle box bearing will cause great loss. Now, condition-based maintenance of train axle box bearing has been a research hotspot around the world. Vibration signals generated by train axle box bearing have nonlinear and nonstationary characteristics. The methods used in traditional bearing fault diagnosis do not work well with the train axle box. To solve this problem, an effective method of axle box bearing fault diagnosis based on multifeature parameters is presented in this paper. This method can be divided into three parts, namely, weak fault signal extraction, feature extraction, and fault recognition. In the first part, a db4 wavelet is employed for denoising the original signals from the vibration sensors. In the second part, five time-domain parameters, five IMF energy-torque features, and two amplitude-ratio features are extracted. The latter seven frequency domain features are calculated based on the empirical mode decomposition and envelope spectrum analysis. In the third part, a fault classifier based on BP neural network is designed for automatic fault pattern recognition. A series of tests are carried out to verify the proposed method, which show that the accuracy is above 90%.

  6. High heritability is compatible with the broad distribution of set point viral load in HIV carriers.

    Directory of Open Access Journals (Sweden)

    Sebastian Bonhoeffer

    2015-02-01

    Full Text Available Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors contribute substantially to the overall variation in viral load. The high heritability is surprising given the diversity of host factors associated with controlling viral infection. Here we develop an analytical model that describes the temporal changes of the distribution of set point viral load as a function of heritability. This model shows that high heritability is the most parsimonious explanation for the observed variance of set point viral load. Our results thus not only reinforce the credibility of previous estimates of heritability but also shed new light onto mechanisms of viral pathogenesis.

  7. 拖拉机前桥悬架参数匹配及其对振动特性的影响%Front axle suspension parameters match and its impact on vibration characteristics of tractor

    Institute of Scientific and Technical Information of China (English)

    伊力达尔·伊力亚斯; 朱思洪; 徐刚; 袁加奇

    2015-01-01

    Compared with cars, buses and trucks, tractor often drives on the dirt road in the field of rural areas, together with the simple vibration damping device, so the vibration of tractor is particularly intense. Severe vibration of tractor would cause serious harm to driver’s health, and cause fatigue and failure of tractor parts and hence seriously affect the life of the tractor. In addition, excessive vibration of the tractor will exacerbate farmland soil compaction and reduce crop yields. How to effectively reduce the vibration of tractors to improve ride comfort and driving safety and reduce farmland damage is an important research topic for researchers and tractor manufacturing enterprises. The study of foreign scholars have found when the tractor is installed with front axle suspension, the ride comfort and driving safety is improved. When farm tools hangs on the front of tractor, tractor damping effect depends on the matching between front axle suspension stiffness and damping coefficient. Installing the front axle suspension of tractor can significantly reduce tractor’s pitching vibration. By the method of theoretical analysis, the theoretical system of front axle suspension of tractor was established, the vibration was analyzed and the theoretical formula was deduced, aiming to provide a theoretical basis for parameter matching of tractor front axle suspension. In this paper, CF700 tractor from Jiang Su Chang-Fa group was taken as the research object, and the theoretical model of front axle suspension tractor was established, including plane vibration model of front axle suspension tractor with 3 degrees of freedom, vibration differential equation and tractor vibration characteristics evaluation. Taking body vertical vibration acceleration, body pitching vibration angular acceleration, seat-mounted vertical vibration acceleration, front and rear wheels’ dynamic load and front axle suspension dynamic deflection as the evaluation means, theoretical

  8. Dynamic Characteristics of a New Machine for Fatigue Testing of Railway Axles – Part 2

    Directory of Open Access Journals (Sweden)

    Karel FRYDRÝŠEK

    2012-06-01

    Full Text Available There were done some proposal calculations for a new testing machine. This new testing machine is determined for a dynamic fatigue testing of railway axles. The railway axles are subjected to bending and rotation (centrifugal effects. For the right proposition of a new machine is very important to know the basic dynamic characteristics of whole system. These dynamic characteristics are solved via FEM (MSC.Marc/Mentat software in combination with SBRA (Simulation-Based Reliability Assessment Method (probabilistic Monte Carlo approach, Anthill and Python software. The proposed dimensions and springs of a new machine for fatigue testing of railway axles were used for manufacturing. Application of the SBRA method connected with FEM in these areas is a new and innovative trend in mechanics. This paper is continuation of former work (i.e. easier deterministic approach already presented in this journal in 2007.

  9. Miniaturized MEMS-Based Gas Chromatograph for High Inertial Loads Associated with Planetary Missions Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Thorleaf Research, Inc. proposes to develop a rugged, miniaturized, low power MEMS-based gas chromatograph (GC) capable of handling the high inertial loads...

  10. Some important aspects in testing high-modulus fiber composite tubes designed for multiaxial loading.

    Science.gov (United States)

    Sullivan, T. L.; Chamis, C. C.

    1972-01-01

    Tubular specimens were potted in metal grips to determine the feasibility of this gripping method in applying multiaxial loads. Strain gage rosettes were used to assess grip transitional strains, through thickness strain variation and strain variations along the tube length and circumference. The investigation was limited to loading 0, 45, plus or minus 45, and 90 deg graphite/epoxy and glass/epoxy tubes in axial tension. Results include modifications made to the grips to reduce transitional strains, illustrations of the tube failure modes, and some material properties. The gripping concept shows promise as a satisfactory technique for applying multiaxial loads to high-strength, high-modulus fiber composite tubes.

  11. Preparation of Multiwall Carbon Nanotubes-supported High Loading Platinum for Vehicular PEMFC Application

    Institute of Scientific and Technical Information of China (English)

    Bing ZHANG; Li Juan CHEN; Kai Yong GE; Yan Chuan GUO; Bi Xian PENG

    2005-01-01

    Multiwall carbon nanotube-supported Pt (Pt/MWNTs) catalysts with high dispersion and high loading of Pt were prepared by chemical reduction method and the loading of Pt got to 40wt%. The average diameter of Pt nanoparticles on MWNTs was about 3.5 nm. When the hydrogen and air were used as reactant gases for PEMFC, Pt/MWNTs catalysts showed significantly higher performance than the Pt/XC-72 (carbon black) catalysts.

  12. Nutrition Coupled with High-Load Traditional or Low-Load Blood Flow Restricted Exercise During Human Limb Suspension

    Science.gov (United States)

    Hackney, K. J.; Everett, M.; Ploutz-Snyder, L. L.

    2011-01-01

    High-load resistance exercise (HRE) and low-load blood flow restricted (BFR) exercise have demonstrated efficacy for attenuating unloading related muscle atrophy and dysfunction. In recreational exercisers, protein consumption immediately before and/or after exercise has been shown to increase the skeletal muscle anabolic response to resistance training. PURPOSE: To compare the skeletal muscle adaptations when chocolate milk intake was coupled with HRE or low-load BFR exercise [3 d/wk] during simulated lower limb weightlessness. METHODS: Eleven subjects were counterbalanced [based on age and gender] to HRE (31 +/- 14 yr, 170 +/- 13 cm, 71 +/- 18 kg, 2M/3W) or low-load BFR exercise (31 +/- 12 yr, 169 +/- 13 cm, 66 +/- 14 kg, 2M/4W) during 30 days of unilateral lower limb suspension (ULLS). Both HRE and BFR completed 3 sets of single leg press and calf raise exercise during ULLS. BFR exercise intensity was 20% of repetition maximum (1RM) with a cuff inflation pressure of 1.3 systolic blood pressure (143 4 mmHg). Cuff pressure was maintained during all 3 sets including rest intervals (90s). HRE intensity was 75% 1RM and was performed without cuff inflation. Immediately (chocolate milk (150 kcal, 2.5g total fat, 22g total carbohydrate, 8g protein) was consumed to optimize acute exercise responses in favor of muscle anabolism. ULLS analog compliance was assessed from leg skin temperature recordings and plantar accelerometry. Muscle cross-sectional area (CSA) for knee extensor and plantar flexor muscle groups were determined from analysis of magnetic resonance images using ImageJ software. 1RM strength for leg press and calf raise was assessed on the Agaton exercise system. Muscular endurance during leg press and calf raise was evaluated from the maximal number of repetitions performed to volitional fatigue using 40% of pre-ULLS 1RM. RESULTS: Steps detected by plantar acceleometry declined by 98.9% during ULLS relative to an ambulatory control period. Average skin

  13. A criterion for high-cycle fatigue life and fatigue limit prediction in biaxial loading conditions

    Institute of Scientific and Technical Information of China (English)

    ukasz Pejkowski; Dariusz Skibicki

    2016-01-01

    This paper presents a criterion for high-cycle fatigue life and fatigue strength estimation under periodic proportional and non-proportional cyclic loading. The cri-terion is based on the mean and maximum values of the second invariant of the stress deviator. Important elements of the criterion are: function of the non-proportionality of fatigue loading and the materials parameter that expresses the materials sensitivity to non-proportional loading. The methods for the materials parameters determination uses three S–N curves: tension–compression, torsion, and any non-proportional loading proposed. The criterion has been verified using experimental data, and the results are included in the paper. These results should be considered as promis-ing. The paper also includes a proposal for multiaxial fatigue models classification due to the approach for the non-proportionality of loading.

  14. Surface modifications of W divertor components for EAST during exposure to high heat loads with He

    Energy Technology Data Exchange (ETDEWEB)

    Li, C., E-mail: lichun10@mails.tsinghua.edu.cn [Laboratory of Advanced Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084 (China); Greuner, H. [Max Planck Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany); Yuan, Y. [School of Physics and Nuclear Energy Engineering, Beihang University, Beijing 100191 (China); Zhao, S.X.; Luo, G.N. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Böswirth, B. [Max Planck Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany); Fu, B.Q.; Jia, Y.Z. [Laboratory of Advanced Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084 (China); Liu, X. [Southwestern Institute of Physics, Chengdu, Sichuan 610041 (China); Liu, W., E-mail: liuw@mail.tsinghua.edu.cn [Laboratory of Advanced Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084 (China)

    2015-08-15

    Flat-type W/Cu plasma-facing components have been developed for the new generation divertor of the Chinese Experimental Advanced Superconducting Tokamak. Surface modifications of such actively water-cooled W components following short and long pulse high heat loading coupled with He particle loads with fluence of 3 × 10{sup 22} m{sup −2} have been investigated. An adiabatically loaded W block was investigated as a comparison and exposed to short pulse loads. Blistering was observed on all sample surfaces, but was less pronounced on the components than on the W block, due to the significant lower surface temperature caused by active cooling. For components, longer pulse loads gave rise to a rougher surface. Furthermore, most blisters on components are found to be less than 1 μm in diameter, with just a very few blisters larger than 1 μm, observed only in some near 〈1 1 1〉 grains.

  15. Highly Loaded Fan by Using Tandem Cascade Rotor Blade

    Science.gov (United States)

    Hasegawa, Hiroaki; Suga, Shinya; Matsuoka, Akinori

    For axial flow compressors and fans in the aircraft engines higher pressure ratio is required in order to attain the high thrust engines. In this study, the fan with the tandem cascades was introduced to increase the fan pressure ratio. The use of tandem cascades in the fan allows savings in length and weight and therefore a compact fan could be built. The design of fan with tandem cascades and the fan testing were carried out to develop the high pressure ratio fan for the Air Turbo Ramjet (ATR) propulsion system. The ATR is a combined cycle engine which performs like a turbojet engine at subsonic speeds and a ramjet at supersonic speeds. In particular, high fan pressure ratio contributes to increase the engine thrust during subsonic flight at which the engine does not make use of ram effect. The results of the fan testing indicate that the pressure ratio of 2.2 is achieved in single stage fan.

  16. Axl signaling induces development of natural killer cells in vitro and in vivo.

    Science.gov (United States)

    Kim, Eun-Mi; Lee, Eun-Hee; Lee, Hwa-Yeon; Choi, Ha-Rim; Ji, Kon-Young; Kim, Su-Man; Kim, Kwang Dong; Kang, Hyung-Sik

    2017-03-01

    Natural killer (NK) cells have been well known to play a critical role in innate immunity, but they are also capable of regulating adaptive immunity through the induction of T cell-mediated memory response and B cell-mediated autoimmune response. NK cells are differentiated from hematopoietic stem cells (HSCs) in the bone marrow (BM), and a series of surface molecules are expressed on NK cells in a differentiation stage-specific manner. Axl receptor tyrosine kinase is originally identified as homeostatic regulators for antigen-presenting cells, and its ligand, growth-arrest-specific gene 6 (Gas6), has been reported to promote cell survival, proliferation, and migration, but their regulatory role in the development and effector function of NK cells is not yet fully understood. In this study, to investigate whether Axl is required for the regulation of NK cell development, the expression of mature NK (mNK) cell-specific receptors and NK cell-associated genes was analyzed in the differentiated HSCs-derived NK cells in vitro and the NK cells harvested from Axl(-/-) mice. We found that agonistic anti-Axl antibody or recombinant Gas6 specifically upregulated the expression of mNK cell-specific receptors, such as LY49A, Ly49G2, Ly49C/F/I, NKG2A/C/E (1.5- to 3.5-fold increase), and NK cell-associated genes, such as IL-2Rβ (2.3- or 2.4-fold increase), Perforin (4.1- or 2.1-fold increase), IL-15Rα (2.14- or 2.04-fold increase), and IFN-γ (3.3- or 2.8-fold increase) compared to each isotype control, whereas it was abrogated by treatment of Axl-Ig. Anti-Axl antibody or rGas6 also induced a 2.5- or 1.9-fold increase in the proliferation of developing NK cells compared to each control, respectively. mNK cell populations expressing mNK cell-specific receptors were reduced about twofold in NK cells differentiated from HSCs of Axl(-/-) mice compared with those of wild-type mice. Furthermore, the triggering of Axl signaling by agonistic anti-Axl antibody promoted the

  17. Hybrid Superconducting Magnetic Bearing (HSMB) for high load devices

    Science.gov (United States)

    McMichael, C. K.; Ma, K. B.; Lamb, M. A.; Lin, M. W.; Chow, L.; Meng, R. L.; Hor, P. H.; Chu, W. K.

    1992-05-01

    Lifting capacities greater than 41 N/cm(exp 2) (60 psi) at 77 K have been achieved with a new type of levitation (hybrid) using a combination of permanent magnets and high quality melt-mixtured YBa2Cu3O(7-delta) (YBCO). The key concept of the hybrid superconducting magnetic bearing (HSMB) is the use of strong magnetic repulsion and attraction from permanent magnets for high levitation or suspension forces in conjunction with a superconductor's flux pinning characteristics to counteract the inherent instabilities in a system consisting of magnets only. To illustrate this concept, radial and axial forces between magnet/superconductor, magnet/magnet, and magnet/superconductor/magnet, were measured and compared for the thrust bearing configuration

  18. Mesoscale modeling of metal-loaded high explosives

    Energy Technology Data Exchange (ETDEWEB)

    Bdzil, John Bohdan [Los Alamos National Laboratory; Lieberthal, Brandon [UNIV OF ILLINOIS; Srewart, Donald S [UNIV OF ILLINOIS

    2010-01-01

    We describe a 3D approach to modeling multi-phase blast explosive, which is primarily condensed explosive by volume with inert embedded particles. These embedded particles are uniform in size and placed on the array of a regular lattice. The asymptotic theory of detonation shock dynamics governs the detonation shock propagation in the explosive. Mesoscale hydrodynamic simulations are used to show how the particles are compressed, deformed, and accelerated by the high-speed detonation products flow.

  19. Dynamic Response of RPC-Filled Steel Tubular Columns with High Load Carrying Capacity Under Axial Impact Loading

    Institute of Scientific and Technical Information of China (English)

    TIAN Zhimin; WU Ping'an; JIA Jianwei

    2008-01-01

    Experimental investigation into impact-resistant behavior of reactive powder concrete (RPC)-filled steel tubular columns was conducted, and dynamic response of the columns under axial impact loading was studied by means of numerical simulation method.Increase coefficient of load carrying capacity and ratio of load carrying capacity between steel tube and RPC core of columns were obtained.

  20. Biodegradation and kinetics of aerobic granules under high organic loading rates in sequencing batch reactor.

    Science.gov (United States)

    Chen, Yao; Jiang, Wenju; Liang, David Tee; Tay, Joo Hwa

    2008-05-01

    Biodegradation, kinetics, and microbial diversity of aerobic granules were investigated under a high range of organic loading rate 6.0 to 12.0 kg chemical oxygen demand (COD) m(-3) day(-1) in a sequencing batch reactor. The selection and enriching of different bacterial species under different organic loading rates had an important effect on the characteristics and performance of the mature aerobic granules and caused the difference on granular biodegradation and kinetic behaviors. Good granular characteristics and performance were presented at steady state under various organic loading rates. Larger and denser aerobic granules were developed and stabilized at relatively higher organic loading rates with decreased bioactivity in terms of specific oxygen utilization rate and specific growth rate (muoverall) or solid retention time. The decrease of bioactivity was helpful to maintain granule stability under high organic loading rates and improve reactor operation. The corresponding biokinetic coefficients of endogenous decay rate (kd), observed yield (Yobs), and theoretical yield (Y) were measured and calculated in this study. As the increase of organic loading rate, a decreased net sludge production (Yobs) is associated with an increased solid retention time, while kd and Y changed insignificantly and can be regarded as constants under different organic loading rates.

  1. An integrated control strategy for the composite braking system of an electric vehicle with independently driven axles

    Science.gov (United States)

    Sun, Fengchun; Liu, Wei; He, Hongwen; Guo, Hongqiang

    2016-08-01

    For an electric vehicle with independently driven axles, an integrated braking control strategy was proposed to coordinate the regenerative braking and the hydraulic braking. The integrated strategy includes three modes, namely the hybrid composite mode, the parallel composite mode and the pure hydraulic mode. For the hybrid composite mode and the parallel composite mode, the coefficients of distributing the braking force between the hydraulic braking and the two motors' regenerative braking were optimised offline, and the response surfaces related to the driving state parameters were established. Meanwhile, the six-sigma method was applied to deal with the uncertainty problems for reliability. Additionally, the pure hydraulic mode is activated to ensure the braking safety and stability when the predictive failure of the response surfaces occurs. Experimental results under given braking conditions showed that the braking requirements could be well met with high braking stability and energy regeneration rate, and the reliability of the braking strategy was guaranteed on general braking conditions.

  2. FEM analysis of front axle vertical finishing process and mold development%前轴垂直整形工艺模拟与模具开发

    Institute of Scientific and Technical Information of China (English)

    曾琦; 蒋鹏

    2013-01-01

    Front axle is one of the important load parts in automobiles, the possibility of the front axle vertical finishing process was analyzed, the process parameters and mold structure of vertical finishing process were simulated and optimized with the help of computer numerical simulation technology. A kind of vertical finishing mold with hydraulic clamping system was designed on the basis of simulations. After vertical finishing process in the vertical finishing mold, the upper and lower surfaces of the spring seat are flattening, which can be drilled bolt holes and mounted directly. It is benefit for reducing the subsequent processing amount and meeting, which mounting requirements of spring seat.%前轴是汽车重要的承载件之一,本文分析了前轴锻件垂直整形工艺的可行性,通过计算机数值模拟技术模拟并优化垂直整形的工艺参数和模具结构,在模拟分析基础上设计出液压夹紧式垂直整形模.经垂直整形后,锻件弹簧座的上下表面基本压平,可以直接加工螺栓孔并进行安装,减少了后续加工量,并保证了弹簧座的安装要求.

  3. High Nutrient Load Increases Biostabilization of Sediment by Biofilms

    Science.gov (United States)

    Valentine, K.; Mariotti, G.

    2016-12-01

    Benthic biofilms, matrixes of microbial cells and their secretions, have been shown to stabilize sediment in coastal environments. While there have been numerous studies on the effects of nutrients on the ability of vascular plants to stabilize sediment, few studies have investigated how nutrients affect biofilm growth and their ability to stabilize sediment. Diatom-based biofilms were grown in laboratory experiments on a settled bed of bentonite clay, under a saline water column with varying amounts of nutrients. Erodibility at different stages of biofilm growth was measured using a Gust Erosion Microcosm System, which applied shear stresses from 0.05 to 0.6 Pa. Biofilms more than one week old decreased the erodibility of the sediments in all nutrient treatments compared to abiotic experiments. With high nutrients, the biofilm grew the fastest; the erodibility decreased within two weeks of biofilm growth and remained low for all applied shear stresses. After four weeks of biofilm growth, no erosion of sediment occurred even at the highest applied shear stress (0.6 Pa). With low nutrients the erodibility decreased within three weeks. With no nutrients the biofilms grew similarly to those with low nutrients; the erodibility decreased within three weeks under shear stresses 0.05-0.45 Pa, but the sediments were eroded under high shear stresses. Under low to moderate shear stresses (0.05-0.45 Pa), the total mass eroded by all experiments with biofilms was similar, suggesting that any amount of biofilm decreases erodibility at low shear stresses. In summary, high nutrients allow for faster biostabilization and for resistance to extreme shear stresses. These results suggest that eutrophication would not decrease the biofilm ability to stabilize muddy sediments in coastal environment.

  4. Modeling and Depletion Simulations for a High Flux Isotope Reactor Cycle with a Representative Experiment Loading

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, David [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division; Betzler, Ben [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division; Hirtz, Gregory John [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division; Ilas, Germina [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division; Sunny, Eva [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division

    2016-09-01

    The purpose of this report is to document a high-fidelity VESTA/MCNP High Flux Isotope Reactor (HFIR) core model that features a new, representative experiment loading. This model, which represents the current, high-enriched uranium fuel core, will serve as a reference for low-enriched uranium conversion studies, safety-basis calculations, and other research activities. A new experiment loading model was developed to better represent current, typical experiment loadings, in comparison to the experiment loading included in the model for Cycle 400 (operated in 2004). The new experiment loading model for the flux trap target region includes full length 252Cf production targets, 75Se production capsules, 63Ni production capsules, a 188W production capsule, and various materials irradiation targets. Fully loaded 238Pu production targets are modeled in eleven vertical experiment facilities located in the beryllium reflector. Other changes compared to the Cycle 400 model are the high-fidelity modeling of the fuel element side plates and the material composition of the control elements. Results obtained from the depletion simulations with the new model are presented, with a focus on time-dependent isotopic composition of irradiated fuel and single cycle isotope production metrics.

  5. A method for calculation of finite fatigue life under multiaxial loading in high-cycle domain

    Directory of Open Access Journals (Sweden)

    M. Malnati

    2014-04-01

    Full Text Available A method for fatigue life assessment in high-cycle domain under multiaxial loading is presented in this paper. This approach allows fatigue assessment under any kind of load history, without limitations. The methodology lies on the construction - at a macroscopic level - of an “indicator” in the form of a set of cycles, representing plasticity that can arise at mesoscopic level throughout fatigue process. During the advancement of the loading history new cycles are created and a continuous evaluation of the damage is made.

  6. Optimization of biomethanation focusing on high ammonia loaded processes

    DEFF Research Database (Denmark)

    Wang, Han

    , could theoretically mitigate the ammonia inhibition problem (Angelidaki et al., 1999). Therefore, the effect of co-digestion of cattle manure with lipids (i.e. glycerol trioleate (GTO)) under high ammonia levels (5 g NH4+-N·L-1) in anaerobic continuous stirred tank (CSTR) reactors (RGTO) was assessed....... Additionally, for comparison purposes, a soluble carbohydrate (i.e. glucose) was also used as a co-substrate in an identical CSTR reactor (RGLU). At 5 g NH4+-N·L-1, relative methane production of RGTO and RGLU, was 10.5% and 41% compared to the expected uninhibited production, respectively. At the same time...... control reactor (RCTL), only fed with manure, reached 32.7% compared to the uninhibited basis production. Therefore, the hypothesis that the co-digestion of manure with lipids could alleviate the ammonia inhibition was not supported by the results. However, an “ammonia-LCFA synergetic inhibitory effect...

  7. Gadolinium loaded plastic scintillators for high efficiency neutron detection

    Science.gov (United States)

    Ovechkina, Lena; Riley, Kent; Miller, Stuart; Bell, Zane; Nagarkar, Vivek

    2009-08-01

    Gadolinium has the highest thermal neutron absorption cross section of any naturally occurring element, and emits conversion electrons as well as atomic X-rays in over 50% of its neutron captures, which makes it a useful dopant in scintillators for detecting thermal neutrons. Gadolinium isopropoxide was studied as a possible dopant for styrene-based plastic scintillators as a convenient and inexpensive method to produce high-efficiency thermal neutron detectors. Plastic scintillators with gadolinium weight concentrations of up to 3% were transparent, uniform and defect-free and were characterized with spectral measurements performed under x-ray and neutron irradiation. The new material has the same characteristic emission of styrene with a maximum at approximately 425 nm, and a light output of 76% relative to the undoped plastic. A 13 mm thick sample containing 0.5% gadolinium by weight detected 46% of incident thermal neutrons, which makes this an attractive material for a variety of applications.

  8. High strain rate loading of polymeric foams and solid plastics

    Science.gov (United States)

    Dick, Richard D.; Chang, Peter C.; Fourney, William L.

    2000-04-01

    The split-Hopkinson pressure bar (SHPB) provided a technique to determine the high strain rate response for low density foams and solid ABS and polypropylene plastics. These materials are used in the interior safety panels of automobiles and crash test dummies. Because the foams have a very low impedance, polycarbonate bars were used to acquire the strain rate data in the 100 to 1600 l/s range. An aluminum SPHB setup was used to obtain the solid plastics data which covered strain rates of 1000 to 4000 l/s. The curves for peak strain rate versus peak stress for the foams over the test range studied indicates only a slight strain rate dependence. Peak strain rate versus peak stress curves for polypropylene shows a strain rate dependence up to about 1500 l/s. At that rate the solid poly propylene indicates no strain rate dependence. The ABS plastics are strain rate dependent up to 3500 l/s and then are independent at larger strain rates.

  9. AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus.

    Science.gov (United States)

    Liu, Shufeng; DeLalio, Leon J; Isakson, Brant E; Wang, Tony T

    2016-11-11

    The mosquito-borne Zika virus (ZIKV) is now recognized as a blood-borne pathogen, raising an important question about how the virus gets into human bloodstream. The imminent threat of the ZIKV epidemic to the global blood supply also demands novel therapeutics to stop virus transmission though transfusion. We intend to characterize ZIKV tropism for human endothelial cells (ECs) and provide potential targets for intervention. We conducted immunostaining, plaque assay, and quantitative reverse transcription-polymerase chain reaction of ZIKV RNA to evaluate the possible infection of ECs by ZIKV. Both the African and the South American ZIKV strains readily infect human umbilical vein endothelial cells and human ECs derived from aortic and coronary artery, as well as the saphenous vein. Infected ECs released infectious progeny virus. Compared with the African strains, South American ZIKV isolates replicate faster in ECs and are partially cytopathic, suggesting enhanced virulence of these isolates. Flow cytometric analyses showed that the susceptibility of ECs positively correlated with the cell surface levels of tyrosine-protein kinase receptor UFO (AXL) receptor tyrosine kinase. Gain- and loss-of-function studies further revealed that AXL is required for ZIKV entry at a postbinding step. Finally, small-molecule inhibitors of the AXL kinase significantly reduced ZIKA infection of ECs. We identified EC as a key cell type for ZIKV infection. These data support the view of hematogenous dissemination of ZIKV and implicate AXL as a new target for antiviral therapy. © 2016 American Heart Association, Inc.

  10. Dynamics of two-axle railway freight wagons with UIC standard suspension

    DEFF Research Database (Denmark)

    Hoffmann, Mark; True, Hans

    2006-01-01

    The dynamics of two different two-axle railway freight wagons is investigated theoretically and compared. Fully nonlinear models are considered. The hysteresis from dry friction and the effect of impacts between elements of the suspension are included. Bifurcation diagrams are shown in order...

  11. Wheeled Vehicle Drive Lines, Axles, and Suspension Systems. Military Curriculum Materials for Vocational and Technical Education.

    Science.gov (United States)

    Army Ordnance Center and School, Aberdeen Proving Ground, MD.

    This course is one of several subcourses that make up the entire Army correspondence course on wheeled vehicle maintenance. The subcourse is designed to provide the student with information about the operation, malfunction diagnosis, maintenance, and repair of wheeled vehicle drive lines, axles, and suspension systems. It provides the basic…

  12. On Optimizing Steering Performance of Multi-axle Vehicle Based on Driving Force Control

    Directory of Open Access Journals (Sweden)

    Wu Zhicheng

    2017-01-01

    Full Text Available The steering performance of multi-axle vehicle with independent driving system is affected by the distribution of the wheel driving force. A nonlinear vehicle dynamics model including magic formula tire model for describing 11 DoF four-axle vehicle with dual-front-axle-steering (DFAS system was presented. The influence of different driving force distribution scheme on the steering performance of the vehicle was analyzed. A control strategy for improving the steady response and transient response of the vehicle steering is proposed. The results show: For the steady response, setting different drive force for internal and external wheels according to the actual steering characteristics of the vehicle can effectively improve its steering characteristics; For the transient response, adopting the zero sideslip angle control strategy and using the PID control algorithm to control the driving force of the outside wheel of tear-two-axle, under angle step input, the vehicle sideslip angle can quickly stabilize to 0 and yaw rate also significantly decreases.

  13. CFD simulations of transient load change on a high head Francis turbine

    Science.gov (United States)

    Jakobsen, Ken-Robert G.; Aasved Holst, Martin

    2017-01-01

    Motivated by the importance of better understanding the structural integrity of high-head hydraulic turbines operating at intermittent conditions, complete 360º steady-state and transient simulations of a Francis turbine are presented in this paper. The main target of the work has been to investigate different numerical approaches such as mesh deformation for different operating conditions. Steady-state simulations were performed at the best efficiency point (BEP) and used as initial conditions for the transient simulations considering load rejection from BEP to part load (BEP2PL) and during load acceptance from BEP to high load (BEP2HL). Simulation results were compared with experimental data available for the Francis-99 project where close agreement was found for the mesh independent solution. The transient load analyses showed general trends in accordance with the measurement reports, especially for the pressure in vaneless space that is of high importance regarding RSI effects. Some deviations were identified for the net head at load rejection for which further investigations will be conducted. All CFD simulations were performed at model scale with ANSYS CFX v. 17 at either 96 or 120 cores (2.60 GHz). The immersed boundary technique was tested during the initial stages of the project, but had to be abandoned due to severe memory requirements. Pressure amplitudes and other instantaneous results were not considered.

  14. Trabecular bone adaptation to low-magnitude high-frequency loading in microgravity.

    Science.gov (United States)

    Torcasio, Antonia; Jähn, Katharina; Van Guyse, Maarten; Spaepen, Pieter; Tami, Andrea E; Vander Sloten, Jos; Stoddart, Martin J; van Lenthe, G Harry

    2014-01-01

    Exposure to microgravity causes loss of lower body bone mass in some astronauts. Low-magnitude high-frequency loading can stimulate bone formation on earth. Here we hypothesized that low-magnitude high-frequency loading will also stimulate bone formation under microgravity conditions. Two groups of six bovine cancellous bone explants were cultured at microgravity on a Russian Foton-M3 spacecraft and were either loaded dynamically using a sinusoidal curve or experienced only a static load. Comparable reference groups were investigated at normal gravity. Bone structure was assessed by histology, and mechanical competence was quantified using μCT and FE modelling; bone remodelling was assessed by fluorescent labelling and secreted bone turnover markers. Statistical analyses on morphometric parameters and apparent stiffness did not reveal significant differences between the treatment groups. The release of bone formation marker from the groups cultured at normal gravity increased significantly from the first to the second week of the experiment by 90.4% and 82.5% in response to static and dynamic loading, respectively. Bone resorption markers decreased significantly for the groups cultured at microgravity by 7.5% and 8.0% in response to static and dynamic loading, respectively. We found low strain magnitudes to drive bone turnover when applied at high frequency, and this to be valid at normal as well as at microgravity. In conclusion, we found the effect of mechanical loading on trabecular bone to be regulated mainly by an increase of bone formation at normal gravity and by a decrease in bone resorption at microgravity. Additional studies with extended experimental time and increased samples number appear necessary for a further understanding of the anabolic potential of dynamic loading on bone quality and mechanical competence.

  15. Trabecular bone adaptation to low-magnitude high-frequency loading in microgravity.

    Directory of Open Access Journals (Sweden)

    Antonia Torcasio

    Full Text Available Exposure to microgravity causes loss of lower body bone mass in some astronauts. Low-magnitude high-frequency loading can stimulate bone formation on earth. Here we hypothesized that low-magnitude high-frequency loading will also stimulate bone formation under microgravity conditions. Two groups of six bovine cancellous bone explants were cultured at microgravity on a Russian Foton-M3 spacecraft and were either loaded dynamically using a sinusoidal curve or experienced only a static load. Comparable reference groups were investigated at normal gravity. Bone structure was assessed by histology, and mechanical competence was quantified using μCT and FE modelling; bone remodelling was assessed by fluorescent labelling and secreted bone turnover markers. Statistical analyses on morphometric parameters and apparent stiffness did not reveal significant differences between the treatment groups. The release of bone formation marker from the groups cultured at normal gravity increased significantly from the first to the second week of the experiment by 90.4% and 82.5% in response to static and dynamic loading, respectively. Bone resorption markers decreased significantly for the groups cultured at microgravity by 7.5% and 8.0% in response to static and dynamic loading, respectively. We found low strain magnitudes to drive bone turnover when applied at high frequency, and this to be valid at normal as well as at microgravity. In conclusion, we found the effect of mechanical loading on trabecular bone to be regulated mainly by an increase of bone formation at normal gravity and by a decrease in bone resorption at microgravity. Additional studies with extended experimental time and increased samples number appear necessary for a further understanding of the anabolic potential of dynamic loading on bone quality and mechanical competence.

  16. Fatigue in Welded High-Strength Steel Plate Elements under Stochastic Loading

    DEFF Research Database (Denmark)

    Agerskov, Henning; Petersen, R.I.; Martinez, L. Lopez

    1999-01-01

    The present project is a part of an investigation on fatigue in offshore structures in high-strength steel. The fatigue life of plate elements with welded attachments is studied. The material used has a yield stress of ~ 810-840 MPa, and high weldability and toughness properties. Fatigue test...... series with constant amplitude loading and with various types of stochastic loading have been carried through on test specimens in high-strength steel, and - for a comparison - on test specimens in conventional offshore structural steel with a yield stress of ~ 400-410 MPa.A comparison between constant...... amplitude and variable amplitude fatigue test results shows shorter fatigue lives in variable amplitude loading than should be expected from the linear fatigue damage accumulation formula. Furthermore, in general longer fatigue lives were obtained for the test specimens in high-strength steel than those...

  17. High Pt Loading on Polydopamine Functionalized Graphene as a High Performance Cathode Electrocatalyst for Proton Exchange Membrane Fuel Cells

    OpenAIRE

    Monireh Faraji; Hussein Gharibi; Masoumeh Javaheri

    2016-01-01

    Morphology and size of platinum nanoparticles are a crucial factor in improving their catalytic activity and stability. Here, we firstly report the synthesis of high loading Pt nanoparticles on polydopamine reduced Graphene. The loading concentration of Pt (nanoparticles) NPs on Graphene can be adjusted in the range of 60-70%.With the insertion of polydopamine between Graphene oxide sheets, stacking of Graphene can be effectively prevented, promoting diffusion of oxygen molecules through the ...

  18. Similarity and cascade flow characteristics of a highly loaded helium compressor

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Bin, E-mail: jiangbin_hrbeu@163.com [College of Power & Energy Engineering of Harbin Engineering University, Harbin 150001 (China); Chen, Zhongliang [College of Power & Energy Engineering of Harbin Engineering University, Harbin 150001 (China); Chen, Hang [AVIG Shenyang Engine Design and Research Institute, Shenyang 110015 (China); Zhang, Hai; Zheng, Qun [College of Power & Energy Engineering of Harbin Engineering University, Harbin 150001 (China)

    2015-05-15

    Highlights: • The deviation of different similarity criteria is analyzed theoretically. • Flow difference between helium and air compressor cascades is analyzed numerically. • The analysis of calculated results validates the theoretical derivation. • Flow characteristics of highly loaded helium compressor blade profile are computed. - Abstract: Helium compressor is a major component of the Power Conversion Unit (PCU) used in a High Temperature Gas Cooled Reactor (HTGR). Because the high cost of closed cycle test and leakage problem of helium gas, air could be used as working fluid instead of helium in compressor performance tests. However, the properties of Helium are largely different from those of air, e.g. the adiabatic exponent of Helium is 1.6, while the adiabatic exponent itself is a criterion of similarity between the two compressors. The characteristics of compressor will be different due to the effect of the adiabatic exponent of working fluid, especially for highly loaded compressor working at higher inlet Mach number. In this paper, a theoretical study on the similarity between air compressor and a highly loaded helium compressor is carried out and the deviation of similarity is analyzed. Numerical simulations are then used to confirm the theoretical analysis. The results indicate that the similarity deviation could not be neglected for highly loaded compressor cascade, which means the experience and experimental results of those conventional air compressor cannot be applied directly to the design of highly loaded helium compressor. The flow characteristics of a highly loaded helium compressor at different Reynolds numbers, attack angles, Mach numbers and cascade geometries are then investigated.

  19. An in vitro scratch tendon tissue injury model: effects of high frequency low magnitude loading.

    Science.gov (United States)

    Adekanmbi, Isaiah; Zargar, Nasim; Hulley, Philippa

    2017-03-01

    The healing process of ruptured tendons is suboptimal, taking months to achieve tissue with inferior properties to healthy tendon. Mechanical loading has been shown to positively influence tendon healing. However, high frequency low magnitude (HFLM) loads, which have shown promise in maintaining healthy tendon properties, have not been studied with in vitro injury models. Here, we present and validate an in vitro scratch tendon tissue injury model to investigate effects of HFLM loading on the properties of injured rat tail tendon fascicles (RTTFs). A longitudinal tendon tear was simulated using a needle aseptically to scratch a defined length along individual RTTFs. Tissue viability, biomechanical, and biochemical parameters were investigated before and 7 days after culture . The effects of static, HFLM (20 Hz), and low frequency (1 Hz) cyclic loading or no load were also investigated. Tendon viability was confirmed in damaged RTTFs after 7 days of culture, and the effects of a 0.77 ± 0.06 cm scratch on the mechanical property (tangent modulus) and tissue metabolism in damaged tendons were consistent, showing significant damage severity compared with intact tendons. Damaged tendon fascicles receiving HFLM (20 Hz) loads displayed significantly higher mean tangent modulus than unloaded damaged tendons (212.7 ± 14.94 v 92.7 ± 15.59 MPa), and damaged tendons receiving static loading (117.9 ± 10.65 MPa). HFLM stimulation maintained metabolic activity in 7-day cultured damaged tendons at similar levels to fresh tendons immediately following damage. Only damaged tendons receiving HFLM loads showed significantly higher metabolism than unloaded damaged tendons (relative fluorescence units -7021 ± 635.9 v 3745.1 ± 641.7). These validation data support the use of the custom-made in vitro injury model for investigating the potential of HFLM loading interventions in treating damaged tendons.

  20. Use of the soluble form of AXL in the diagnosis and/or prognosis of heart failure syndrome

    OpenAIRE

    Battle Perales, Montserrat; García de Frutos, Pablo

    2012-01-01

    [EN] The present invention refers to a method for diagnosing and/or prognosing a heart failure syndrome (HF), which comprises the step of measuring, in vitro, the amount of the soluble form of AXL (sAXL) in a test sample. The invention furthermore provides methods for deciding or recommending whether to initiate a medical regimen, as well as for determining the efficacy of said medical regimen. The invention also provides the use of sAXL as a marker for the diagnosis and/or prognosis of HF sA...

  1. Beyond perception: testing for implicit conceptual traces in high-load tasks.

    Science.gov (United States)

    Ruz, María; Fuentes, Luis J

    2009-09-01

    The present commentary addresses the main results obtained in the Butler and Klein [Butler, B. C., & Klein, R. (2009). Inattentional blindness for ignored words: Comparison of explicit and implicit memory tasks. Consciousness and Cognition, 18, 811-819.] study and discusses them in relation to the Perceptual Load Theory of Lavie [Lavie, N. (1995). Perceptual load as a necessary condition for selective attention. Journal of Experimental Psychology: Human Perception and Performance, 21, 451-68.]. The authors claim that the use of implicit indexes of conceptual distractor processing in high-load situations would be an important addition to the load literature, which would benefit the research field regardless of their positive or negative findings.

  2. High Powered Tests of Dielectric Loaded High Pressure RF Cavities for Use in Muon Cooling Channels

    Energy Technology Data Exchange (ETDEWEB)

    Freemire, Ben [IIT, Chicago; Bowring, Daniel [Fermilab; Kochemirovskiy, Alexey [Chicago U.; Moretti, Alfred [Fermilab; Peterson, David [Fermilab; Tollestrup, Alvin [Fermilab; Torun, Yagmur [IIT, Chicago; Yonehara, Katsuya [Fermilab

    2016-06-01

    Bright muon sources require six dimensional cooling to achieve acceptable luminosities. Ionization cooling is the only known method able to do so within the muon lifetime. One proposed cooling channel, the Helical Cooling Channel, utilizes gas filled radio frequency cavities to both mitigate RF breakdown in the presence of strong, external magnetic fields, and provide the cooling medium. Engineering constraints on the diameter of the magnets within which these cavities operate dictate the radius of the cavities be decreased at their nominal operating frequency. To accomplish this, one may load the cavities with a larger dielectric material. Alumina of purities ranging from 96 to 99.8% was tested in a high pressure RF test cell at the MuCool Test Area at Fermilab. The results of breakdown studies with pure nitrogen gas, and oxygen-doped nitrogen gas indicate the peak surface electric field on the alumina ranges between 10 and 15 MV/m. How these results affect the design of a prototype cooling channel cavity will be discussed.

  3. Dynamic Axle Loads as a Main Source of Railway Track Degradation

    NARCIS (Netherlands)

    Steenbergen, M.J.M.M.; De Jong, E.; Zoeteman, A.

    2015-01-01

    During train operation, geometrical irregularities develop in soil-supported ballasted railway tracks as a function of born tonnage. This form of degradation is combatted by periodic maintenance in the form of tamping by specially equipped trains in order to guarantee predefined levels of structural

  4. Performance of rotating drum biofilter for volatile organic compound removal at high organic loading rates

    Institute of Scientific and Technical Information of China (English)

    YANG Chunping; CHEN Hong; ZENG Guangming; ZHU Xueqing; SUIDAN Makram T

    2008-01-01

    Uneven distribution of volatile organic compounds (VOCs) and biomass,and excess biomass accumulation in some biofilters hinder the application of biofiltration technology.An innovative multilayer rotating drum biofilter (RDB) was developed to correct these problems.The RDB was operated at an empty bed contact time (EBCT) of 30 s and a rotational rate of 1.0 r/rain.Diethyl ether was chosen as the model VOC.Performance of the RDB was evaluated at organic loading rates of 32.1,64.2,128,and 256 g ether/(m3·h) (16.06 g ether/(m3·h) ≈1.0 kg chemical oxygen demand (COD)/(m3·d)).The EBCT and organic loading rates were recorded on the basis of the medium volume.Results show that the ether removal efficiency decreased with an increased VOC loading rate.Ether removal efficiencies exceeding 99% were achieved without biomass control even at a high VOC loading rate of 128 g ether/(m3·h). However,when the VOC loading rate was increased to 256 g ether/(m3·h),the average removal efficiency dropped to 43%.Nutrient limitation possibly contributed to the drop in ether removal efficiency.High biomass accumulation rate was also observed in the medium at the two higher ether loading rates,and removal of the excess biomass in the media was necessary to maintain stable performance. This work showed that the RDB is effective in the removal of diethyl ether from waste gas streams even at high organic loading rates. The results might help establish criteria for designing and operating RDBs.

  5. Total protein or high-abundance protein: Which offers the best loading control for Western blotting?

    Science.gov (United States)

    Thacker, Jonathan S; Yeung, Derrick H; Staines, W Richard; Mielke, John G

    2016-03-01

    Western blotting routinely involves a control for variability in the amount of protein across immunoblot lanes. Normalizing a target signal to one found for an abundantly expressed protein is widely regarded as a reliable loading control; however, this approach is being increasingly questioned. As a result, we compared blotting for two high-abundance proteins (actin and glyceraldehyde 3-phosphate dehydrogenase [GAPDH]) and two total protein membrane staining methods (Ponceau and Coomassie Brilliant Blue) to determine the best control for loading variability. We found that Ponceau staining optimally balanced accuracy and precision, and we suggest that this approach be considered as an alternative to normalizing with a high-abundance protein.

  6. High-voltage transmission tower-line system subjected to disaster loads

    Institute of Scientific and Technical Information of China (English)

    LI Hongnan; BAI Haifeng

    2006-01-01

    The high-voltage power transmission system is an important lifeline structure. It is significant for wide researches on the features and ability of the system subjected to earthquake and environmental loads. The promising prosperity of the system has been demonstrated around the world. The corresponding advances of the system with respect to the mechanism of loading action, analytical methods, experimental research measurements, structural vibration control, fatigue damage, lifetime prediction, and design methods are comprehensively discussed herein. Finally, further research work on dynamic response characteristics of high-voltage transmission towerline system in the near future is predicted.

  7. Better target detection in the presence of collinear flankers under high working memory load

    Directory of Open Access Journals (Sweden)

    Jan W. De Fockert

    2014-10-01

    Full Text Available There are multiple ways in which working memory can influence selective attention. Aside from the content-specific effects of working memory on selective attention, whereby attention is more likely to be directed towards information that matches the contents of working memory, the mere level of load on working memory has also been shown to have an effect on selective attention. Specifically, high load on working memory is associated with increased processing of irrelevant information. In most demonstrations of the effect to-date, this has led to impaired target performance, leaving open the possibility that the effect partly reflects an increase in general task difficulty under high load. Here we show that working memory load can result in a performance gain when processing of distracting information aids target performance. The facilitation in the detection of a low-contrast Gabor stimulus in the presence of collinear flanking Gabors was greater when load on a concurrent working memory task was high, compared to low. This finding suggests that working memory can interact with selective attention at an early stage in visual processing.

  8. High-loading Fe2O3/SWNT composite films for lithium-ion battery applications

    Science.gov (United States)

    Wang, Ying; Guo, Jiahui; Li, Li; Ge, Yali; Li, Baojun; Zhang, Yingjiu; Shang, Yuanyuan; Cao, Anyuan

    2017-08-01

    Single-walled carbon nanotube (SWNT) films are a potential candidate as porous conductive electrodes for energy conversion and storage; tailoring the loading and distribution of active materials grafted on SWNTs is critical for achieving maximum performance. Here, we show that as-synthesized SWNT samples containing residual Fe catalyst can be directly converted to Fe2O3/SWNT composite films by thermal annealing in air. The mass loading of Fe2O3 nanoparticles is tunable from 63 wt% up to 96 wt%, depending on the annealing temperature (from 450 °C to 600 °C), while maintaining the porous network structure. Interconnected SWNT networks containing high-loading active oxides lead to synergistic effect as an anode material for lithium ion batteries. The performance is improved consistently with increasing Fe2O3 loading. As a result, our Fe2O3/SWNT composite films exhibit a high reversible capacity (1007.1 mA h g-1 at a current density of 200 mA g-1), excellent rate capability (384.9 mA h g-1 at 5 A g-1) and stable cycling performance with the discharge capacity up to 567.1 mA h g-1 after 600 cycles at 2 A g-1. The high-loading Fe2O3/SWNT composite films have potential applications as nanostructured electrodes for various energy devices such as supercapacitors and Li-ion batteries.

  9. Microbial response and elimination capacity in biofilters subjected to high toluene loadings.

    Science.gov (United States)

    Song, JiHyeon; Kinney, Kerry A

    2005-09-01

    Elimination capacity (EC) is frequently used as a performance and design criterion for vapor-phase biofilters without further verification of the microbial quantity and activity. This study was conducted to investigate how biofilters respond to high pollutant loadings and ultimately how this affects the EC of the biofilter. Two identical laboratory-scale biofilters were maintained at an initial toluene loading rate of 46 g m-3 h-1 for a period of 24 days. After the initial biofilm development stage, the loading rates were increased to 91 g m-3 h-1 and 137 g m-3 h-1, respectively. Following a short period of pseudo-steady state, toluene removal efficiencies rapidly declined in both biofilters, with a concurrent decline in both critical and maximum ECs. The decline was mainly due to deterioration in the biodegradation activity of the biofilm and a decline in the toluene-degrading bacterial population within the biofilm phase. The findings imply that high toluene loadings accelerated the deterioration in overall performance due to a rapid accumulation of inactive biomass. As a result, care must be used when relying on EC values for biofilter design and operational purposes, since the values do not appropriately reflect the temporal changes in biodegradation activity and active biomass quantities that can occur in biofilters subjected to high inlet loadings.

  10. Thermal shock behaviour of tungsten after high flux H-plasma loading

    Science.gov (United States)

    Wirtz, M.; Linke, J.; Pintsuk, G.; De Temmerman, G.; Wright, G. M.

    2013-11-01

    Previous studies have shown that transient thermal shock loads induce crack networks on tungsten samples especially at low base temperatures. To achieve test conditions which are more relevant for the performance of tungsten-armoured plasma facing components in next step thermonuclear fusion devices tungsten tiles were exposed to high flux hydrogen-plasma in the linear plasma generator Pilot-PSI and the high heat flux ion beam test facility MARION. Subsequently, the cyclic transient heat load tests were done in the electron beam facility JUDITH 1. The induced damages after these combined tests were examined by microscopically means, profilometry and metallography. The comparison of the obtained results and damage characteristics with those obtained after thermal shock loading show that the preloading of tungsten targets with high flux hydrogen-plasma has significant influence on the thermal shock behaviour of tungsten in terms of crack distance, width, and depth as well as cracked area. Furthermore the plasma parameters, in particular pulse duration and sample temperature during loading, have strong impact on the damage pattern after thermal shock loading.

  11. Polybiguanide (PHMB) loaded in PLA scaffolds displaying high hydrophobic, biocompatibility and antibacterial properties

    Energy Technology Data Exchange (ETDEWEB)

    Llorens, Elena; Calderón, Silvia [Departament d' Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, Barcelona E-08028 (Spain); Valle, Luis J. del, E-mail: luis.javier.del.valle@upc.edu [Departament d' Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, Barcelona E-08028 (Spain); Puiggalí, Jordi [Departament d' Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, Barcelona E-08028 (Spain); Center for Research in Nano-Engineering (CrNE), Universitat Politècnica de Catalunya, Edifici C, C/Pasqual i Vila s/n, Barcelona E-08028 (Spain)

    2015-05-01

    Polyhexamethylenebiguanide hydrochloride (PHMB), a low molecular weight polymer related to chlorohexidine (CHX), is a well-known antibacterial agent. In this study, polylactide (PLA) nanofibers loaded with PHMB were produced by electrospinning to obtain 3D biodegradable scaffolds with antibacterial properties. PLA fibers loaded with CHX were used as control. The electrospun fibers were studied and analyzed by SEM, FTIR, DSC and contact angle measurements. PHMB and CHX release from loaded scaffolds was evaluated, as well as their antibacterial activity and biocompatibility. The results showed that the nanofibers became smoother and their diameter smaller with increasing the amount of loaded PHMB. This feature led to an increase of both surface roughness and hydrophobicity of the scaffold. PHMB release was highly dependent on the hydrophilicity of the medium and differed from that determined for CHX. Lastly, PHMB-loaded PLA scaffolds showed antibacterial properties since they inhibited adhesion and bacterial growth, and exhibited biocompatible characteristics for the adhesion and proliferation of both fibroblast and epithelial cell lines. - Highlights: • Nanofibers of PLA-PHMB (antibacterial polymer) were prepared by electrospinning. • PHMB has hydrophilic character but the PLA-PHMB scaffolds were highly hydrophobic. • The high-hydrophobicity of the new scaffolds conditioned the release of PHMB. • The controlled release of PHMB inhibited the growth and bacterial adhesion. • PLA-PHMB scaffolds have biocompatibility with fibroblast and epithelial cells.

  12. Change in the locus of dynamic loading axis on the knee joint after high tibial osteotomy.

    Science.gov (United States)

    Kawakami, Hideo; Sugano, Nobuhiko; Yonenobu, Kazuo; Yoshikawa, Hideki; Ochi, Takahiro; Nakata, Ken; Toritsuka, Yukiyoshi; Hattori, Asaki; Suzuki, Naoki

    2005-04-01

    The purpose of this study was to visualise the locus of the dynamic loading axis on the knee joint, and to evaluate changes in this locus during gait after high tibial osteotomy (HTO) in three patients who underwent HTO for medial compartment osteoarthritis (OA) of a varus knee. The bone structure of the lower limb and the relative position of skin markers were acquired from CT images. Motion capture data was acquired using spherical skin markers. Skeletal model movement during gait was calculated based on the movement of the markers. The locus of the dynamic loading axis on the knee joint was defined as the point on the proximal tibia joint surface that intersected with the loading axis of the lower limb, which passed through the centre of the femoral head and the centroid of multiple points surrounded by the distal tibia joint surface contour. This system was able to visualise the locus of the dynamic loading axis on the knee joint and not only lateral but also anterior-posterior direction movement. After HTO, the locus shifted from a medial and posterior area of the medial joint edge of the knee to a central area of the knee joint surface. This indicates that HTO shifted the dynamic loading axis. Lateral movement of the dynamic loading axis in the early stance phase of gait was reduced within a year after HTO.

  13. Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

    Directory of Open Access Journals (Sweden)

    Prieto Anne L

    2011-05-01

    Full Text Available Abstract Background Axl, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6 are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS lesions, suggesting that it plays a role in disease pathogenesis. To test for this, we studied the susceptibility of Axl-/- mice to experimental autoimmune encephalomyelitis (EAE, an animal model for multiple sclerosis. Methods WT and Axl-/- mice were immunized with myelin oligodendrocyte glycoprotein (MOG35-55 peptide emulsified in complete Freund's adjuvant and injected with pertussis toxin on day 0 and day 2. Mice were monitored daily for clinical signs of disease and analyzed for pathology during the acute phase of disease. Immunological responses were monitored by flow cytometry, cytokine analysis and proliferation assays. Results Axl-/- mice had a significantly more severe acute phase of EAE than WT mice. Axl-/- mice had more spinal cord lesions with larger inflammatory cuffs, more demyelination, and more axonal damage than WT mice during EAE. Strikingly, lesions in Axl-/- mice had more intense Oil-Red-O staining indicative of inefficient clearance of myelin debris. Fewer activated microglia/macrophages (Iba1+ were found in and/or surrounding lesions in Axl-/- mice relative to WT mice. In contrast, no significant differences were noted in immune cell responses between naïve and sensitized animals. Conclusions These data show that Axl alleviates EAE disease progression and suggests that in EAE Axl functions in the recruitment of microglia/macrophages and in the clearance of debris following demyelination. In addition, these data

  14. A FAST BIT-LOADING ALGORITHM FOR HIGH SPEED POWER LINE COMMUNICATIONS

    Institute of Scientific and Technical Information of China (English)

    Zhang Shengqing; Zhao Li; Zou Cairong

    2012-01-01

    Adaptive bit-loading is a key technology in high speed power line communications with the Orthogonal Frequency Division Multiplexing (OFDM) modulation technology.According to the real situation of the transmitting power spectrum limited in high speed power line communications,this paper explored the adaptive bit loading algorithm to maximize transmission bit number when transmitting power spectral density and bit error rate are not exceed upper limit.With the characteristics of the power line channel,first of all,it obtains the optimal bit loading algorithm,and then provides the improved algorithm to reduce the computational complexity.Based on the analysis and simulation,it offers a non-iterative bit allocation algorithm,and finally the simulation shows that this new algorithm can greatly reduce the computational complexity,and the actual bit allocation results close to optimal.

  15. Brittle materials at high-loading rates: an open area of research

    Science.gov (United States)

    Forquin, Pascal

    2017-01-01

    Brittle materials are extensively used in many civil and military applications involving high-strain-rate loadings such as: blasting or percussive drilling of rocks, ballistic impact against ceramic armour or transparent windshields, plastic explosives used to damage or destroy concrete structures, soft or hard impacts against concrete structures and so on. With all of these applications, brittle materials are subjected to intense loadings characterized by medium to extremely high strain rates (few tens to several tens of thousands per second) leading to extreme and/or specific damage modes such as multiple fragmentation, dynamic cracking, pore collapse, shearing, mode II fracturing and/or microplasticity mechanisms in the material. Additionally, brittle materials exhibit complex features such as a strong strain-rate sensitivity and confining pressure sensitivity that justify expending greater research efforts to understand these complex features. Currently, the most popular dynamic testing techniques used for this are based on the use of split Hopkinson pressure bar methodologies and/or plate-impact testing methods. However, these methods do have some critical limitations and drawbacks when used to investigate the behaviour of brittle materials at high loading rates. The present theme issue of Philosophical Transactions A provides an overview of the latest experimental methods and numerical tools that are currently being developed to investigate the behaviour of brittle materials at high loading rates. This article is part of the themed issue 'Experimental testing and modelling of brittle materials at high strain rates'.

  16. Brittle materials at high-loading rates: an open area of research

    Science.gov (United States)

    2017-01-01

    Brittle materials are extensively used in many civil and military applications involving high-strain-rate loadings such as: blasting or percussive drilling of rocks, ballistic impact against ceramic armour or transparent windshields, plastic explosives used to damage or destroy concrete structures, soft or hard impacts against concrete structures and so on. With all of these applications, brittle materials are subjected to intense loadings characterized by medium to extremely high strain rates (few tens to several tens of thousands per second) leading to extreme and/or specific damage modes such as multiple fragmentation, dynamic cracking, pore collapse, shearing, mode II fracturing and/or microplasticity mechanisms in the material. Additionally, brittle materials exhibit complex features such as a strong strain-rate sensitivity and confining pressure sensitivity that justify expending greater research efforts to understand these complex features. Currently, the most popular dynamic testing techniques used for this are based on the use of split Hopkinson pressure bar methodologies and/or plate-impact testing methods. However, these methods do have some critical limitations and drawbacks when used to investigate the behaviour of brittle materials at high loading rates. The present theme issue of Philosophical Transactions A provides an overview of the latest experimental methods and numerical tools that are currently being developed to investigate the behaviour of brittle materials at high loading rates. This article is part of the themed issue ‘Experimental testing and modelling of brittle materials at high strain rates’. PMID:27956517

  17. Material Compressing Test of the High Polymer Part Used in Draft Gear of Heavy Load Locomotive

    Directory of Open Access Journals (Sweden)

    Wei Yangang

    2016-01-01

    Full Text Available According to the actual load cases of heavy load locomotive, the material compressing tests of the high polymer parts used in the locomotive are researched. The relationship between stress and strain during the material compressing are acquired by means of comparing the many results of the material compressing tests under different test condition. The relationship between stress and strain during the material compressing is nonlinear in large range of strain, but the relationship is approximately linear in small range of strain. The material of the high polymer made in China and the material of the high polymer imported are compared through the tests. The results show that the compressing property of the material of the high polymer made in China and the material of the high polymer imported are almost same. The research offers the foundation to study the structure elasticity of the draft gear.

  18. Towards Cognitive-Aware Multimodal Presentation: The Modality Effects in High-Load HCI

    NARCIS (Netherlands)

    Cao, Yujia; Theune, Mariët; Nijholt, Anton; Harris, D,

    2009-01-01

    In this study, we argue that multimodal presentations should be created in a cognitive-aware manner, especially in a high-load HCI situation where the user task challenges the full capacity of the human cognition. An experiment was conducted to investigate the cognitive effects of modalities, using

  19. Influence of different SSF conditions on ethanol production from corn stover at high solids loadings

    DEFF Research Database (Denmark)

    Gladis, Arne; Bondesson, Pia-Maria; Galbe, Mats

    2015-01-01

    In this study, three different kinds of simultaneous saccharification and fermentation (SSF) of washed pretreated corn stover with water-insoluble solids (WIS) content of 20% were investigated to find which one resulted in highest ethanol yield at high-solids loadings. The different methods were...

  20. Fat oxidation before and after a high fat load in the obese insulin-resistant state

    NARCIS (Netherlands)

    Blaak, E.E.; Hul, G.; Verdich, C.; Stich, V.; Martinez, A.; Petersen, M.; Feskens, E.J.M.; Patel, K.; Oppert, J.M.; Barbe, P.; Toubro, S.; Anderson, I.; Polak, J.; Astrup, A.; Macdonald, I.A.; Holst, C.; Sørensen, T.I.; Saris, W.H.

    2006-01-01

    Background: Obesity may be associated with a lowered use of fat as a fuel, which may contribute to the enlarged adipose tissue stores. Aim: The aim of the present study was to study fatty acid use in the fasting state and in response to a high fat load in a large cohort of obese subjects (n = 701) a

  1. A high-rate shape memory alloy actuator for aerodynamic load control on wind turbines

    NARCIS (Netherlands)

    Lara-Quintanilla, A.; Hulskamp, A.W.; Bersee, H.E.N.

    2013-01-01

    This paper discusses the development of a high rate shape memory alloy (SMA) driven actuator. The concept of the actuator was developed to act as aerodynamic load control surface on wind turbines. It was designed as a plate or beam-like structure with prestrained SMA wires embedded off its neutral a

  2. Residual stress in a M3:2 PM high speed steel; effect of mechanical loading

    DEFF Research Database (Denmark)

    Højerslev, Christian; Odén, Magnus; Carstensen, Jesper V.;

    2001-01-01

    X-ray lattice strains were investigated in an AISI M3:2 PM high-speed steel in the as heat treated condition and after exposure to alternating mechanical load. The volume changes during heat treatment were monitored with dilatometry. Hardened and tempered AISI M3:2 steel consists of tempered lath...

  3. High HPV 16 viral load is associated with increased cervical dysplasia in Honduran women.

    NARCIS (Netherlands)

    Tabora, N.; Ferrera, A.; Bakkers, J.M.J.E.; Massuger, L.F.A.G.; Melchers, W.J.G.

    2008-01-01

    Cervical cancer is believed to have a co-factorial etiology in which high-risk human papillomavirus (HPV) infections are considered an essential factor and other elements play an ancillary role. Besides the importance of specific HPV genotypes, other viral cofactors as viral load may influence the

  4. Fat oxidation before and after a high fat load in the obese insulin-resistant state

    NARCIS (Netherlands)

    Blaak, E.E.; Hul, G.; Verdich, C.; Stich, V.; Martinez, A.; Petersen, M.; Feskens, E.J.M.; Patel, K.; Oppert, J.M.; Barbe, P.; Toubro, S.; Anderson, I.; Polak, J.; Astrup, A.; Macdonald, I.A.; Holst, C.; Sørensen, T.I.; Saris, W.H.

    2006-01-01

    Background: Obesity may be associated with a lowered use of fat as a fuel, which may contribute to the enlarged adipose tissue stores. Aim: The aim of the present study was to study fatty acid use in the fasting state and in response to a high fat load in a large cohort of obese subjects (n = 701)

  5. Effect of dissolved oxygen concentration on the bioflocculation process in high loaded MBRs

    NARCIS (Netherlands)

    Faust, L.; Temmink, B.G.; Zwijnenburg, A.; Kemperman, A.J.B.; Rijnaarts, H.

    2014-01-01

    High-loaded membrane bioreactors (HL-MBRs), i.e. MBRs which are operated at extremely short sludge and hydraulic retention times, can be applied to flocculate and concentrate sewage organic matter. The concentrated organics can be used for energy recovery, or for the production of more valuable

  6. Acute Effects of Low-Load/High-Repetition Single-Limb Resistance Training in COPD.

    Science.gov (United States)

    Nyberg, André; Saey, Didier; Martin, Mickaël; Maltais, François

    2016-12-01

    Exercising small muscle groups at a time allows higher muscle specific workloads compared with whole body aerobic exercises in people with chronic obstructive pulmonary disease (COPD). Whether similar effects also occur with partitioning exercise during low load/high-repetition resistance exercises is uncertain.

  7. New impact specimen for adhesives: optimization of high-speed-loaded adhesive joints

    NARCIS (Netherlands)

    Bezemer, A.A.; Guyt, C.B.; Vlot, A.

    1998-01-01

    A new kind of joint specimen has been developed to load the adhesive in pure shear on impact. The specimen is tested with three adhesives at five layer thicknesses, and at three test speeds. From these tests it can be concluded that the rod-ring specimen is suitable for use in impact tests at high s

  8. Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents

    Directory of Open Access Journals (Sweden)

    Fone-Ching Hsiao

    2014-01-01

    Full Text Available The present study was designed to explore the effects of GAS6 and AXL gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents. After multistage sampling from the data of the Taipei Children Heart Study-III, we collected 358 boys and 369 girls with an average age of 13.3 years. We genotyped the adolescents’ GAS6 rs8191973, GAS6 rs8191974, AXL rs4802113, and AXL rs2304232 polymorphisms. Significantly higher body mass index (BMI, waist circumference (WC, and hsCRP levels were found in boys with the GG genotype of GAS6 rs8191974 than A allele carriers; higher IL-6 and insulin levels and increased HOMA-IR were found in boys with the GG genotype of AXL rs2304232 than the A allele carriers. There was a significant difference in hsCRP levels of boys with the TT, TC, and CC genotypes of AXL rs4802113. Boys with both the GG genotype of GAS6 rs8191973 and the GG genotype of GAS6 rs8191974 exhibited higher BMI, WC, IL-6, and hsCRP levels than the boys carrying both the C allele of the GAS6 rs8191973 and the A allele of the GAS6 rs8191974. In conclusion, GAS6 and AXL polymorphisms are associated with adiposity, systemic inflammation, and insulin resistance in adolescents, especially in boys.

  9. Note: High resolution ultra fast high-power pulse generator for inductive load using digital signal processor.

    Science.gov (United States)

    Flaxer, Eli

    2014-08-01

    We present a new design of a compact, ultra fast, high resolution and high-powered, pulse generator for inductive load, using power MOSFET, dedicated gate driver and a digital signal controller. This design is an improved circuit of our old version controller. We demonstrate the performance of this pulse generator as a driver for a new generation of high-pressure supersonic pulsed valves.

  10. 59/74kW轮式拖拉机前驱动桥桥壳的柔性加工工艺设计%Flexible Manufacturing Process of 59/74 kW Tractor Front Drive Axle Housing

    Institute of Scientific and Technical Information of China (English)

    王智红; 张强; 赵利飞; 周珍珠

    2012-01-01

    针对59/74kw轮式拖拉机前驱动桥壳体,分析了整体式桥壳的结构特点和其主减安装面、转向节孔和半轴轴承座孔的工艺要求,并研究设计了加工工艺。经生产实践证明,该工艺不仅生产效率高,而且产品质量稳定。%For front drive axle housing of 59/74 kW tractors,we analyzed the overall structural features of the integral axle housing and process requirements for main mounting surface, steering knuckle hole and half shaft bearing seat hole. Then the process technics are designed. The productions prove that the process has a high efficiency and stabile product quality.

  11. Preliminary C3 Loading Analysis for Future High-Altitude Unmanned Aircraft in the NAS

    Science.gov (United States)

    Ho, Yan-Shek; Gheorghisor, Izabela; Box, Frank

    2006-01-01

    This document provides a preliminary assessment and summary of the command, control, and communications (C(sup 3)) loading requirements of a generic future high-altitude, long-endurance unmanned aircraft (UA) operating at in the National Airspace System. Two principal types of C(sup 3) traffic are considered in our analysis: communications links providing air traffic services (ATS) to the UA and its human pilot, and the command and control data links enabling the pilot to operate the UA remotely. we have quantified the loading requirements of both types of traffic for two different assumed levels of UA autonomy. Our results indicate that the potential use of UA-borne relays for the ATS links, and the degree of autonomy exercised by the UA during the departure and arrival phases of its flight, will be among the key drivers of C(sup 3) loading and bandwidth requirements.

  12. Numerical analysis of high strain rate failure of electro-magnetically loaded steel sheets

    Directory of Open Access Journals (Sweden)

    Erice Borja

    2015-01-01

    Full Text Available Electro-magnetic forces provide a potentially power full means in designing dynamic experiments with active control of the loading conditions. This article deals with the development of computational models to simulate the thermo-mechanical response of electro-magnetically loaded metallic structures. The model assumes linear electromagnetic constitutive equations and time-independent electric induction to estimate the Joule heating and the Lorentz forces. The latter are then taken into account when evaluating stress equilibrium. A thermo-visco-plastic model with Johnson-Cook type of temperature and strain rate dependence and combined Swift-Voce hardening is used to evaluate the material's thermo-mechanical response. As a first application, the model is used to analyse the effect of electro-magnetic loading on the ductility of advanced high strength steels.

  13. Mesoporous TiO2 implants for loading high dosage of antibacterial agent

    Science.gov (United States)

    Park, Se Woong; Lee, Donghyun; Choi, Yong Suk; Jeon, Hoon Bong; Lee, Chang-Hoon; Moon, Ji-Hoi; Kwon, Il Keun

    2014-06-01

    We have fabricated mesoporous thin films composed of TiO2 nanoparticles on anodized titanium implant surfaces for loading drugs at high doses. Surface anodization followed by treatment with TiO2 paste leads to the formation of mechanically stable mesoporous thin films with controllable thickness. A series of antibacterial agents (silver nanoparticles, cephalothin, minocycline, and amoxicillin) were loaded into the mesoporous thin films and their antibacterial activities were evaluated against five bacterial species including three oral pathogens. Additionally, two agents (silver nanoparticles and minocycline) were loaded together on the thin film and tested for antibacterial effectiveness. The combination of silver nanoparticles and minocycline was found to display a wide range of effectiveness against all tested bacteria.

  14. Molecular dynamics simulation of materials response to high strain-rate loading

    Energy Technology Data Exchange (ETDEWEB)

    Belak, J

    1999-07-22

    A molecular dynamics (MD) analysis of conservation of momentum through a shock front is presented. The MD model uses a non-traditional boundary condition that allows simulation in the reference frame of the shock front. Higher order terms proportional to gradients in the density are shown to be non-negligible at the shock front. The simulation is used to study the sequence of thermodynamic states during shock loading. Melting is observed in the simulations, though above the thermodynamic melt curve as is common in homogeneous simulations of melting. High strain-rate tensile loading is applied to the growth of nanoscale voids in copper. Void growth is found to occur by plasticity mechanisms with dislocations emerging from the void surface. [molecular dynamics, shock loading, conservation of momentum, shock melting, void growth

  15. Individual differences at high perceptual load: the relation between trait anxiety and selective attention.

    Science.gov (United States)

    Sadeh, Naomi; Bredemeier, Keith

    2011-06-01

    Attentional control theory (Eysenck et al., 2007) posits that taxing attentional resources impairs performance efficiency in anxious individuals. This theory, however, does not explicitly address if or how the relation between anxiety and attentional control depends upon the perceptual demands of the task at hand. Consequently, the present study examined the relation between trait anxiety and task performance using a perceptual load task (Maylor & Lavie, 1998). Sixty-eight male college students completed a visual search task that indexed processing of irrelevant distractors systematically across four levels of perceptual load. Results indicated that anxiety was related to difficulty suppressing the behavioural effects of irrelevant distractors (i.e., decreased reaction time efficiency) under high, but not low, perceptual loads. In contrast, anxiety was not associated with error rates on the task. These findings are consistent with the prediction that anxiety is associated with impairments in performance efficiency under conditions that tax attentional resources.

  16. The effect of variable stator on performance of a highly loaded tandem axial flow compressor stage

    Science.gov (United States)

    Eshraghi, Hamzeh; Boroomand, Masoud; Tousi, Abolghasem M.; Fallah, Mohammad Toude; Mohammadi, Ali

    2016-06-01

    Increasing the aerodynamic load on compressor blades helps to obtain a higher pressure ratio in lower rotational speeds. Considering the high aerodynamic load effects and structural concerns in the design process, it is possible to obtain higher pressure ratios compared to conventional compressors. However, it must be noted that imposing higher aerodynamic loads results in higher loss coefficients and deteriorates the overall performance. To avoid the loss increase, the boundary layer quality must be studied carefully over the blade suction surface. Employment of advanced shaped airfoils (like CDAs), slotted blades or other boundary layer control methods has helped the designers to use higher aerodynamic loads on compressor blades. Tandem cascade is a passive boundary layer control method, which is based on using the flow momentum to control the boundary layer on the suction surface and also to avoid the probable separation caused by higher aerodynamic loads. In fact, the front pressure side flow momentum helps to compensate the positive pressure gradient over the aft blade's suction side. Also, in comparison to the single blade stators, tandem variable stators have more degrees of freedom, and this issue increases the possibility of finding enhanced conditions in the compressor off-design performance. In the current study, a 3D design procedure for an axial flow tandem compressor stage has been applied to design a highly loaded stage. Following, this design is numerically investigated using a CFD code and the stage characteristic map is reported. Also, the effect of various stator stagger angles on the compressor performance and especially on the compressor surge margin has been discussed. To validate the CFD method, another known compressor stage is presented and its performance is numerically investigated and the results are compared with available experimental results.

  17. The Effect of Variable Stator on Performance of a Highly Loaded Tandem Axial Flow Compressor Stage

    Institute of Scientific and Technical Information of China (English)

    Hamzeh Eshraghi; Masoud Boroomand; Abolghasem M.Tousi; Mohammad Toude Fallah; Ali Mohammadi

    2016-01-01

    Increasing the aerodynamic load on compressor blades helps to obtain a higher pressure ratio in lower rotational speeds.Considering the high aerodynamic load effects and structural concerns in the design process,it is possible to obtain higher pressure ratios compared to conventional compressors.However,it must be noted that imposing higher aerodynamic loads results in higher loss coefficients and deteriorates the overall performance.To avoid the loss increase,the boundary layer quality must be studied carefully over the blade suction surface.Employment of advanced shaped airfoils (like CDAs),slotted blades or other boundary layer control methods has helped the designers to use higher aerodynamic loads on compressor blades.Tandem cascade is a passive boundary layer control method,which is based on using the flow momentum to control the boundary layer on the suction surface and also to avoid the probable separation caused by higher aerodynamic loads.In fact,the front pressure side flow momentum helps to compensate the positive pressure gradient over the aft blade's suction side.Also,in comparison to the single blade stators,tandem variable stators have more degrees of freedom,and this issue increases the possibility of finding enhanced conditions in the compressor off-design performance.In the current study,a 3D design procedure for an axial flow tandem compressor stage has been applied to design a highly loaded stage.Following,this design is numerically investigated using a CFD code and the stage characteristic map is reported.Also,the effect of various stator stagger angles on the compressor performance and especially on the compressor surge margin has been discussed.To validate the CFD method,another known compressor stage is presented and its performance is numerically investigated and the results are compared with available experimental results.

  18. OPTIMAL KINEMATIC DESIGN OF A CAR AXLE GUIDING MECHANISM IN MBS SOFTWARE ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Cătălin ALEXANDRU

    2015-05-01

    Full Text Available This work deals with the optimal kinematic design of the guiding mechanism used for the rear axle of a motor vehicle. A guiding mechanism of type 2S1C (S - sphere, C - circle is taken into consideration, the optimization study being conducted by using the multi-body systems (MBS software environment ADAMS of MSC. The global cartesian coordinates of some design points (the locations of the joints between the guiding arms and car body are used as independent design variables for the optimization study. The main design objectives refer to the longitudinal displacement of the axle and its proper rotation (around the transversal axis, the kinematic optimization goal being to minimize these variations.

  19. IMPACT OF CARBURIZING AND BOROSILICONIZING ON VIBROACCELERATION OF BEVEL GEAR FRONT DRIVE AXLE SKIDDERS DURING OPERATION

    Directory of Open Access Journals (Sweden)

    M. N. Pischov

    2015-01-01

    Full Text Available It is now established that the main causes of failure of the transmission parts of the forest machines is wear of their working surfaces. The destruction of the contact surfaces of bevel gears front axle of skidder TTP-401 during its operation is usually connected, with the formation of plastic deformation on the teeth. According to modern concepts of the theory of the destruction of the details revealed that after the formation of plastic deformations leads to microcracks, the development of micro tracks depends on the magnitude and sign of residual stresses. This article presents dependance graphs of vibration acceleration bevel gears front axle skidder subiect to the method of hardening.

  20. Optimization of Assembly of Rear Axle Carrier (Transmission System Through Ergonomic Consideration: An Overview

    Directory of Open Access Journals (Sweden)

    Mr. Kaustubh N. Kalaspurkar

    2013-05-01

    Full Text Available Increased competition in the market, ever increasing demands of products and delivery of the quality product within committed dates forcing the manufacturers to involve newer and more optimized techniques in their production scheduling. This technique either involves costly Automation and Flexible Manufacturing System (FMS or the techniques forcing on elimination of unnecessary and unproductive operation (i.e. motion during the production. An assembly line is designed by determining the sequences of operations for manufacture of each component as well as the final product. In this paper, a case study at one of leading tractor manufacturing company in India for one of its production operation i.e. assembly of Rear Axle Carrier (Transmission System of tractor is presented using the technique of time and motion study. For this technique such as Predetermined Motion Time Study (PMTS, Method Time Measurement (MTM, various process charts are used for analysis and optimize their present methodology of assembling Rear Axle Carrier (RAC.

  1. Development of a vehicle load control strategy for Malawi for the period 2016 to 2020

    CSIR Research Space (South Africa)

    Roux, MP

    2016-07-01

    Full Text Available Strategy and development of a five-year implementation plan for significantly improving the Directorate’s current capacity to effectively manage and enforce axle load control. Specific objectives were to: a) Assist the DRTSS to undertake an extensive...

  2. Development and Application of Mullite Brick With High Refractoriness under Load and Low Creep

    Institute of Scientific and Technical Information of China (English)

    ZHANGSheng; WANGRuikun; 等

    2000-01-01

    This paper introduces of the development and applica-tion of heavily burned mullited brick with high reractoriness under load low creep,which is made of andalusie fine and coarse grains (as aggregate),high alumina bauxite produced in Yangquan county,clay produced in Guangxi provine,industrial alumina powder and silliman-ite powder (as matrix material) and a little amount of ad-ditives and bonded with synthetic bond.

  3. A layered cooling process in whole quenching process for lightweight front axle beam

    Directory of Open Access Journals (Sweden)

    Gao Kai

    2015-01-01

    Full Text Available In order to improve the uniformity of martensite distribution and obtain consistent mechanical performance during the quenching process of front axle beam, a layered cooling process was presented in this paper. The fluid-solid coupled temperature field were investigated by finite element modeling and the prediction of micro-structure and hardness distributions were also carried out. The experimental result verifies the reliability of this model.

  4. The dynamics of European two-axle railway freight wagons with UIC standard suspension

    DEFF Research Database (Denmark)

    Hoffmann, Mark; True, Hans

    2008-01-01

    The dynamics of two-axle railway freight wagons with the UIC standard Suspension is investigated theoretically and the dynamic behaviour is explained. Fully nonlinear models are considered. The hysteresis from dry friction and the effect of impacts between elements of the suspension are included....... Different wheel-rail geometries are investigated and the results commented. Bifurcation diagrams ale used to describe the eigen-dynamics of the wagons....

  5. Study on End Milling Generation Surface Model and Simulation in View of Main Axle s Tolerance

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In accordance with the relative movement between end-milling cutter and workpiece surface, a theoretical generation model for milled surface was established with the movement error of principal axle considered. Then the milled surfaces under various cutting condition were simulated, the results of which showed that end milled surfaces were of "vaulted profile", heights of surface irregularty at various points to be different with maximum value in the middle and smaller at both sides, the difference were ...

  6. DEVELOPMENT OF AN ARMY STATIONARY AXLE TEST STAND FOR LUBRICANT EFFICIENCY EVALUATION-PART II

    Science.gov (United States)

    2017-01-13

    product endorsement purposes. Contracted Author As the author(s) is(are) not a Government employee (s), this document was only reviewed for...work using the stationary axle efficiency test stand was completed using hardware representative of light and medium duty tactical wheeled vehicles...sufficient motoring and absorption capabilities required to test a wide range of light to heavy duty driveline hardware representative of those fielded by

  7. Correlation analysis of high-risk human papillomavirus viral load and cervical lesions

    Directory of Open Access Journals (Sweden)

    Xiao-xing MA

    2012-05-01

    Full Text Available Objective  To explore the association between high-risk human papillomavirus (HR-HPV viral load and pathological grades of cervical intraepithelial neoplasia (CIN and cervical cancer. Methods  A total of 1248 patients from General Hospital of PLA, who underwent colposcopy and surgery due to cervical lesions between Jan. 2006 and Aug. 2011 were enrolled in this study, and they were divided five groups: cervicitis, CIN Ⅰ, CIN Ⅱ-Ⅲ, stage Ⅰ cervical cancer and stage Ⅱ cervical cancer. HR-HPV viral load (RLU/CO was determined by the Hybrid Capture Ⅱ (HCⅡ system, and they were categorized into five groups: 0-0.99, 1.00-9.99, 10.00-99.99, 100.00-999.99, ≥1000.00. The mean value and standard deviation of different HR-HPV viral load in the patients with cervicitis or with CIN Ⅰ, CINⅡ-Ⅲ, stage Ⅰ cervical cancer or stage Ⅱ cervical cancer were compared, and the correlation of HR-HPV viral load and pathogenesis of cervical lesions was analyzed. Results  HPV viral loads were significantly higher in CINⅠ(842.1±983.9, CINⅡ-Ⅲ (690.1±795.0, stage Ⅰ cervical cancer (893.1±974.2 and stage Ⅱ cervical cancer (699.5±908.3 patients than in cervicitis patients (274.2±613.6, P < 0.05, and the HPV viral loads in CINⅠ(842.1±983.9 and stage Ⅰ cervical cancer patients were higher than those in CINⅡ-Ⅲ patients (P < 0.05. When HR-HPV viral load was ≥100RLU/CO, the risk of CIN and cervical cancer increased with the increase in viral load, but there was no correlation between the viral load and pathological grades of cervical lesions. In the patients with stage ⅠB-Ⅱ cervical squamous cell carcinoma, when the HR-HPV viral load was ≥100RLU/CO, the risk of lymph node metastasis increased (P < 0.05, and the number of patients with maximum diameter of the cervical tumor ≥4cm also increased (P < 0.05. However, the HR-HPV viral load was not correlated with patient age, pathological type of the lesion, depth of cancer

  8. Highly loaded Ni-based catalysts for low temperature ethanol steam reforming

    Science.gov (United States)

    Wang, Tuo; Ma, Hongyan; Zeng, Liang; Li, Di; Tian, Hao; Xiao, Shengning; Gong, Jinlong

    2016-05-01

    This paper describes the design of high-loading Ni/Al2O3 catalysts (78 wt% Ni) for low temperature ethanol steam reforming. The catalysts were synthesized via both co-precipitation (COP) and impregnation (IMP) methods. All the catalysts were measured by N2 adsorption-desorption, XRD, H2-TPR, and H2 pulse chemisorption. The characterization results demonstrated that the preparation method and the loading significantly affected the nickel particle size, active nickel surface area and catalytic performance. Over COP catalysts, large nickel particles were presented in nickel aluminum mixed oxides. In comparison, IMP catalysts gained more ``free'' NiO particles with weak interaction with the aluminum oxide. Consequently, COP catalysts yielded smaller nickel particles and larger active nickel surface areas than those of IMP catalysts. High loading is beneficial for obtaining sufficient active nickel sites when nickel particles are dispersed via COP, whereas excessive nickel content is not desired for catalysts prepared by IMP. Specifically, the 78 wt% nickel loaded catalyst synthesized by COP possessed small nickel particles (~6.0 nm) and an abundant active nickel area (35.1 m2 gcat-1). Consequently, COP-78 achieved superior stability with 92% ethanol conversion and ~35% H2 selectivity at 673 K for 30 h despite the presence of a considerable amount of coke.

  9. Prediction of Stress Concentration effect under Thermal and Dynamic loads on a High Pressure Turbine Rotor

    Directory of Open Access Journals (Sweden)

    R.Nagendra Babu

    2010-08-01

    Full Text Available Geometric discontinuities cause a large variation of stress and produce a significant increase in stress. The high stress due to the variation of geometry is called as ‘stress concentration’. This will increase when the loads are further applied. There are many investigators who have studied the stress distribution around the notches, grooves, and other irregularities of various machine components. This paper analyses the effects of thermal and fatigue load on a steam turbine rotor under the operating conditions. Stresses due to thermal and dynamic loads of High Pressure Steam Turbine Rotor of 210MW power station are found in two stages. A source code is developed for calculating the nominal stress at each section of HPT rotor. Maximum stress is obtained using FEA at the corresponding section. Thermal and Fatigue Stress Concentration Factors at each section are calculated. It is observed that the SCFdue to the combined effect of thermal and dynamic loads at the temperatures beyond 5400C is exceeding the safe limits.

  10. High efficiency WCDMA power amplifier with Pulsed Load Modulation (PLM) technique

    Science.gov (United States)

    Liao, Shu-Hsien

    In wireless communication, high data rate complex modulation is used for spectral efficiency. However, power efficiency of power amplifier degrades when complex modulation is applied. Therefore, efficiency enhancement is necessary to maintain the performance. However, conventional efficiency enhancement schemes are nonlinear and performance improvement can only be optimized over a small range of power level. In order to preserve linearity and power efficiency, we propose a new digital power amplification technique "Pulsed Load Modulation (PLM)" for high efficiency and linear amplification. The PLM technique realizes load impedance modulation in digital fashion which is insensitive to device nonlinearity. Furthermore, the optimum power efficiency can be maintained over a wide range of output power. In this work, a PLM power amplifier module has been fabricated and to demonstrate the ability of PLM to provide high efficiency and linear amplification.

  11. Progress on High Power Tests of Dielectric-Loaded Accelerating Structures

    CERN Document Server

    Jing, Chunguang; Gold, Steven H; Kinkead, Allen; Konecny, Richard; Power, John G

    2005-01-01

    This paper presents a progress report on a series of high-power rf experiments that were carried out to evaluate the potential of the Dielectric-Loaded Accelerating (DLA) structure for high-gradient accelerator operation. Since the last PAC meeting in 2003, we have tested DLA structures loaded with two different ceramic materials: Alumina (Al2O3) and MCT (MgxCa1-xTiO3). The alumina-based DLA experiments have concentrated on the effects of multipactor in the structures under high-power operation, and its suppression using TiN coatings, while the MCT experiments have investigated the dielectric joint breakdown observed in the structures due to local field enhancement. In both cases, physical models have been set up, and the potential engineering solutions are being investigated.

  12. Self-healing of mechanically-loaded self consolidating concretes with high volumes of fly ash

    Energy Technology Data Exchange (ETDEWEB)

    Mustafa Sahmaran; Suleyman B. Keskin; Gozde Ozerkan; Ismail O. Yaman [University of Gaziantep, Gaziantep (Turkey). Department of Civil Engineering

    2008-11-15

    This article discusses the effects of self-healing on self consolidating concretes incorporating high volumes of fly ash (HVFA-SCC) when subjected to continuous water exposure. For this purpose, self consolidating concretes with fly ash replacement ratios of 0%, 35%, and 55% were prepared having a constant water-cementitious material ratio of 0.35. A uniaxial compression load was applied to generate microcracks in concrete where cylindrical specimens were pre-loaded up to 70% and 90% of the ultimate compressive load determined at 28 days. Later, the extent of damage was determined as percentage of loss in mechanical properties and percentage of increase in permeation properties. After pre-loading, concrete specimens were stored in water for a month and the mechanical and permeation properties are monitored at every two weeks. It was observed that HVFA-SCC mixtures initially lost 27% of their strength when pre-loaded up to 90% of their ultimate strength, and after 30 days of water curing that reduction was only 7%, indicating a substantial healing. On the other hand, for SCC specimens without fly ash that were pre-loaded to the same level, the loss in strength was initially 19%, and after a month of moist curing it was only 13%. Similar observations were also made on the permeation properties with greater effects. As the HVFA-SCCs studied have an important amount of unhydrated fly ash available in their microstructure, these observations are attributed to the self-healing of the pre-existing cracks, mainly by hydration of anhydrous fly ash particles on the crack surfaces.

  13. Mechanical model for yield strength of nanocrystalline materials under high strain rate loading

    Institute of Scientific and Technical Information of China (English)

    朱荣涛; 周剑秋; 马璐; 张振忠

    2008-01-01

    To understand the high strain rate deformation mechanism and determine the grain size,strain rate and porosity dependent yield strength of nanocrystalline materials,a new mechanical model based on the deformation mechanism of nanocrystalline materials under high strain rate loading was developed.As a first step of the research,the yield behavior of the nanocrystalline materials under high strain rate loading was mainly concerned in the model and uniform deformation was assumed for simplification.Nanocrystalline materials were treated as composites consisting of grain interior phase and grain boundary phase,and grain interior and grain boundary deformation mechanisms under high strain rate loading were analyzed,then Voigt model was applied to coupling grain boundary constitutive relation with mechanical model for grain interior phase to describe the overall yield mechanical behavior of nanocrystalline materials.The predictions by the developed model on the yield strength of nanocrysatlline materials at high strain rates show good agreements with various experimental data.Further discussion was presented for calculation results and relative experimental observations.

  14. Direct FEM-computation of load carrying capacity of highly loaded passive components; Direkte FEM - Berechnung der Tragfaehigkeit hochbeanspruchter passiver Komponenten

    Energy Technology Data Exchange (ETDEWEB)

    Staat, M.; Heitzer, M. [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Sicherheitsforschung und Reaktortechnik

    1998-11-01

    Detailed, inelastic FEM analyses yield accurate information about the stresses and deformations in passive components. The local loading conditions, however, cannot be directly compared with a limit load in terms of structural mechanics. Concentration on the load carrying capacity is an approach simplifying the analysis. Based on the plasticity theory, limit and shakedown analyses calculate the load carrying capacities directly and exactly. The paper explains the implementation of the limit and shakedown data sets in a general FEM program and the direct calculation of the load carrying capacities of passive components. The concepts used are explained with respect to common structural analysis. Examples assuming high local stresses illustrate the application of FEM-based limit and shakedown analyses. The calculated interaction diagrams present a good insight into the applicable operational loads of individual passive components. The load carrying analysis also opens up a structure mechanics-based approach to assessing the load-to-collapse of cracked components made of highly ductile fracture-resistant material. (orig./CB) [Deutsch] Genaue Kenntnis der Spannungen und Verformungen in passiven Komponenten gewinnt man mit detailierten inelastischen FEM Analysen. Die lokale Beanspruchung laesst sich aber nicht direkt mit einer Beanspruchbarkeit im strukturmechanischen Sinne vergleichen. Konzentriert man sich auf die Frage nach der Tragfaehigkeit, dann vereinfacht sich die Analyse. Im Rahmen der Plastizitaetstheorie berechnen Traglast- und Einspielanalyse die tragbaren Lasten direkt und exakt. In diesem Beitrag wird eine Implementierung der Traglast- und Einspielsaetze in ein allgemeines FEM Programm vorgestellt, mit der die Tragfaehigkeit passiver Komponenten direkt berechnet wird. Die benutzten Konzepte werden in Bezug auf die uebliche Strukturanalyse erlaeutert. Beispiele mit lokal hoher Beanspruchung verdeutlichen die Anwendung der FEM basierten Traglast- und

  15. Flow separation control by using bowed blade in highly loaded turbine cascades

    Institute of Scientific and Technical Information of China (English)

    YAMAMOTO; Atsumasa

    2009-01-01

    Due to the serious flow separations and centralized vortices,there are high secondary losses in highly loaded turbines.It is imperative to find measures to control the flow separation and vortices hence improve the turbine performance.This paper reports our recent progress on flow separation and vor-tices control in highly loaded turbine cascades by using bowed blades.Two sets of highly loaded tur-bine cascades with the turning angles of 113° and 160°,and each with 7 bowed blade angles 0°(straight),±10°,±20° and ±30° were experimentally investigated.Both internal flow field measurement and flow visualization on the blade surfaces were conducted,and the effects of blade bowing on the flow topology,distribution of vorticity and the flow energy loss were discussed.The results show that,for the cascade with the turning angle of 113°,the appropriately positive bow angle could reduce the flow energy loss;whereas for the cascade with the turning angle of 160°,the well selected negative bow angle can give the better aerodynamic performance.

  16. Flow separation control by using bowed blade in highly loaded turbine cascades

    Institute of Scientific and Technical Information of China (English)

    TAN ChunQing; ZHANG HuaLiang; CHEN HaiSheng; DONG XueZhi; ZHAO HongLei; YAMAMOTO Atsumasa

    2009-01-01

    Due to the serious flow separations and centralized vortices, there are high secondary losses in highly loaded turbines. It is imperative to find measures to control the flow separation and vortices hence improve the turbine performance. This paper reports our recent progress on flow separation and vor-tices control in highly loaded turbine cascades by using bowed blades. Two sets of highly loaded tur-bine cascades with the turning angles of 113°and 160°, and each with 7 bowed blade angles 0°(straight),±10°, ±20° and ±30° were experimentally investigated. Both internal flow field measurement and flow visualization on the blade surfaces were conducted, and the effects of blade bowing on the flow topology, distribution of vorticity and the flow energy loss were discussed. The results show that, for the cascade with the turning angle of 113°, the appropriately positive bow angle could reduce the flow energy loss; whereas for the cascade with the turning angle of 160°, the well selected negative bow angle can give the better aerodynamic performance.

  17. Algorithms for Pallet Building and Truck Loading in an Interdepot Transportation Problem

    Directory of Open Access Journals (Sweden)

    Maria Teresa Alonso

    2016-01-01

    Full Text Available This paper deals with the problem of a logistics company that has to serve its customers by first putting the products on pallets and then loading the pallets into trucks. Besides the standard geometric constraints of products not overlapping each other and not exceeding the dimensions of pallets and trucks, in this real problem, there are many other constraints, related to the total weight of the load, the maximum weight supported by each axle, and the distribution of the load inside the truck. Although the problem can be decomposed into two phases, pallet loading and truck loading, we have taken a combined approach, building and placing pallets at the same time. For each position in the truck, a pallet is built and tailored for that position according to the constraints of height and weight. We have developed a GRASP algorithm, in which the constructive algorithm is randomized and an improvement phase is added to obtain high-quality solutions. The algorithm has been tested on two sets of real instances with different characteristics, involving up to 44 trucks. The results show that solutions with an optimal or near optimal number of trucks are obtained in very short computing times.

  18. Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men.

    Directory of Open Access Journals (Sweden)

    Nicholas A Burd

    Full Text Available BACKGROUND: We aimed to determine the effect of resistance exercise intensity (%1 repetition maximum-1RM and volume on muscle protein synthesis, anabolic signaling, and myogenic gene expression. METHODOLOGY/PRINCIPAL FINDINGS: Fifteen men (21+/-1 years; BMI=24.1+/-0.8 kg/m2 performed 4 sets of unilateral leg extension exercise at different exercise loads and/or volumes: 90% of repetition maximum (1RM until volitional failure (90FAIL, 30% 1RM work-matched to 90%FAIL (30WM, or 30% 1RM performed until volitional failure (30FAIL. Infusion of [ring-13C6] phenylalanine with biopsies was used to measure rates of mixed (MIX, myofibrillar (MYO, and sarcoplasmic (SARC protein synthesis at rest, and 4 h and 24 h after exercise. Exercise at 30WM induced a significant increase above rest in MIX (121% and MYO (87% protein synthesis at 4 h post-exercise and but at 24 h in the MIX only. The increase in the rate of protein synthesis in MIX and MYO at 4 h post-exercise with 90FAIL and 30FAIL was greater than 30WM, with no difference between these conditions; however, MYO remained elevated (199% above rest at 24 h only in 30FAIL. There was a significant increase in AktSer473 at 24h in all conditions (P=0.023 and mTORSer2448 phosphorylation at 4 h post-exercise (P=0.025. Phosporylation of Erk1/2Tyr202/204, p70S6KThr389, and 4E-BP1Thr37/46 increased significantly (P<0.05 only in the 30FAIL condition at 4 h post-exercise, whereas, 4E-BP1Thr37/46 phosphorylation was greater 24 h after exercise than at rest in both 90FAIL (237% and 30FAIL (312% conditions. Pax7 mRNA expression increased at 24 h post-exercise (P=0.02 regardless of condition. The mRNA expression of MyoD and myogenin were consistently elevated in the 30FAIL condition. CONCLUSIONS/SIGNIFICANCE: These results suggest that low-load high volume resistance exercise is more effective in inducing acute muscle anabolism than high-load low volume or work matched resistance exercise modes.

  19. Aerodynamic loading distribution effects on the overall performance of ultra-high-lift LP turbine cascades

    Science.gov (United States)

    Berrino, M.; Satta, F.; Simoni, D.; Ubaldi, M.; Zunino, P.; Bertini, F.

    2014-02-01

    The present paper reports the results of an experimental investigation aimed at comparing aerodynamic performance of three low-pressure turbine cascades for several Reynolds numbers under steady and unsteady inflows. This study is focused on finding design criteria useful to reduce both profile and secondary losses in the aero-engine LP turbine for the different flight conditions. The baseline blade cascade, characterized by a standard aerodynamic loading (Zw=1.03), has been compared with two Ultra-High-Lift profiles with the same Zweifel number (Zw=1.3 for both cascades), but different velocity peak positions, leading to front and mid-loaded blade cascade configurations. The aerodynamic flow fields downstream of the cascades have been experimentally investigated for Reynolds numbers in the range 70000plane downstream of the cascade for both inflow conditions. The analysis of the results allows the evaluation of the aerodynamic performance of the blade cascades in terms of profile and secondary losses and the understanding of the effects of loading distribution and Zweifel number on secondary flows. When operating under unsteady inflow, contrarily to the steady case, the mid-loaded cascade has been found to be characterized by the lowest profile and secondary losses, making it the most attractive solution for the design of blades working in real conditions where unsteady inflow effects are present.

  20. Crystallization Kinetics of Indomethacin/Polyethylene Glycol Dispersions Containing High Drug Loadings.

    Science.gov (United States)

    Duong, Tu Van; Van Humbeeck, Jan; Van den Mooter, Guy

    2015-07-06

    The reproducibility and consistency of physicochemical properties and pharmaceutical performance are major concerns during preparation of solid dispersions. The crystallization kinetics of drug/polyethylene glycol solid dispersions, an important factor that is governed by the properties of both drug and polymer has not been adequately explored, especially in systems containing high drug loadings. In this paper, by using standard and modulated differential scanning calorimetry and X-ray powder diffraction, we describe the influence of drug loading on crystallization behavior of dispersions made up of indomethacin and polyethylene glycol 6000. Higher drug loading increases the amorphicity of the polymer and inhibits the crystallization of PEG. At 52% drug loading, polyethylene glycol was completely transformed to the amorphous state. To the best of our knowledge, this is the first detailed investigation of the solubilization effect of a low molecular weight drug on a semicrystalline polymer in their dispersions. In mixtures containing up to 55% indomethacin, the dispersions exhibited distinct glass transition events resulting from amorphous-amorphous phase separation which generates polymer-rich and drug-rich domains upon the solidification of supercooled polyethylene glycol, whereas samples containing at least 60% drug showed a single amorphous phase during the period in which crystallization normally occurs. The current study demonstrates a wide range in physicochemical properties of drug/polyethylene glycol solid dispersions as a result of the complex nature in crystallization of this system, which should be taken into account during preparation and storage.

  1. Enzymatic hydrolysis of pelletized AFEX™-treated corn stover at high solid loadings.

    Science.gov (United States)

    Bals, Bryan D; Gunawan, Christa; Moore, Janette; Teymouri, Farzaneh; Dale, Bruce E

    2014-02-01

    Ammonia fiber expansion (AFEX™) pretreatment can be performed at small depots, and the pretreated biomass can then be pelletized and shipped to a centralized refinery. To determine the feasibility of this approach, pelletized AFEX-treated corn stover was hydrolyzed at high (18-36%) solid loadings. Water absorption and retention by the pellets was low compared to unpelletized stover, which allowed enzymatic hydrolysis slurries to remain well mixed without the need for fed-batch addition. Glucose yields of 68% and xylose yields of 65% were obtained with 20 mg enzyme/g glucan and 18% solid loading after 72 h, compared to 61% and 59% for unpelletized corn stover. Pelletization also slightly increased the initial rate of hydrolysis compared to unpelletized biomass. The ease of mixing and high yields obtained suggests that pelletization after AFEX pretreatment could have additional advantages beyond improved logistical handling of biomass.

  2. EFFECTS OF HIGH-IMPACT MECHANICAL LOADING ON SYNOVIAL CELL CULTURES

    Directory of Open Access Journals (Sweden)

    Hui Bin Sun

    2004-03-01

    Full Text Available Cartilage metabolism in response to mechanical loading is an important subject in sports science and medicine. In animal studies high-impact exercise is known to stimulate bone adaptation and increase bone mass. However, mechanical impacts potentially induce tissue swelling and occasionally degradation of connective tissues in synovium and articular cartilage. These detrimental outcomes should be properly evaluated clinically and biochemically. Using two synovial cell cultures derived from normal and rheumatic tissues, we examined the biochemical effects of impulsive mechanical loads on expression and activities of influential proteolytic enzymes in joints, matrix metalloproteinases (MMPs, and their natural inhibitors, tissue inhibitors of metalloproteinases (TIMPs. The molecular analysis demonstrates that an impact factor (Im, the ratio of the maximum force to weight, served as a good indicator for assessment of the inflammatory responses. The results showed that high impact above Im = 40 to 80 elevated not only expression but also enzymatic activities of MMPs

  3. Beam Test of a Dielectric Loaded High Pressure RF Cavity for Use in Muon Cooling Channels

    Energy Technology Data Exchange (ETDEWEB)

    Freemire, Ben [IIT, Chicago; Bowring, Daniel [Fermilab; Kochemirovskiy, Alexey [Chicago U.; Moretti, Alfred [Fermilab; Peterson, David [Fermilab; Tollestrup, Alvin [Fermilab; Torun, Yagmur [IIT, Chicago; Yonehara, Katsuya [Fermilab

    2016-06-01

    Bright muon sources require six dimensional cooling to achieve acceptable luminosities. Ionization cooling is the only known method able to do so within the muon lifetime. One proposed cooling channel, the Helical Cooling Channel, utilizes gas filled radio frequency cavities to both mitigate RF breakdown in the presence of strong, external magnetic fields, and provide the cooling medium. Engineering constraints on the diameter of the magnets within which these cavities operate dictate the radius of the cavities be decreased at their nominal operating frequency. To accomplish this, one may load the cavities with a larger dielectric material. A 99.5% alumina ring was inserted in a high pressure RF test cell and subjected to an intense proton beam at the MuCool Test Area at Fermilab. The results of the performance of this dielectric loaded high pressure RF cavity will be presented.

  4. Molecular dynamics simulation of functionalized graphene surface for high efficient loading of doxorubicin

    Science.gov (United States)

    Mirhosseini, Mohammad Masoud; Rahmati, Mahmoud; Zargarian, Seyed Shahrooz; Khordad, Reza

    2017-08-01

    Molecular dynamics simulations are performed to study the design and optimization of nanocarriers with high drug loading capacity. Functionalized graphene is considered as the nominated high capacity drug carrier and Dox as the drug model. The graphene surface functionalized with hydroxyl (- OH), carboxyl (- COOH), methyl (- CH3) and amine (- NH2) groups and their associated properties are investigated. The simulation results are illustrated that G - COOH surface absorbs Dox more effectively in comparison to other functionalized graphene surfaces due to the higher binding energy of carboxylic groups and the model drug. The effect of hydrogen bonding, temperature and surface porosity are also evaluated. The results show that binding energy and the solubility parameter are temperature-dependent. The simulation results in this present work reveal the underlying mechanisms of Dox loading on neat and functionalized graphene surfaces may be employed to design better graphene-based nanocarriers for the Dox delivery applications.

  5. Investigation of Internal Flow in Ultra—Highly Loaded Turbine Cascade by PIV Method

    Institute of Scientific and Technical Information of China (English)

    A.Senoo; S.MizukiandH.Tsujita; 等

    2000-01-01

    The highly loaded turbine blades are able to reduce both the number of blades and the stages of turbojet-engines.In this study,PIV(Particle Image Velocimetry)method is used for the measuremts of the secondary flow in ultra-highly loaded tubine blade casecades.The results obtained by the PIV method clearly show the complicated behavior of the secondary flow in the cascade.The horseshoe vortex and the passage vortex are observed inside the cascade,Moreover.the wake generated by the accumulation of the low energy fluid by the passage vortex near the suction side and that discharged toward downstream of the trailing edge has been recognized.

  6. The role of volume-load in strength and absolute endurance adaptations in adolescent's performing high- or low-load resistance training.

    Science.gov (United States)

    Steele, James; Fisher, James P; Assunção, Ari R; Bottaro, Martim; Gentil, Paulo

    2017-02-01

    This study compared high- (HL) and low-load (LL) resistance training (RT) on strength, absolute endurance, volume-load, and their relationships in untrained adolescents. Thirty-three untrained adolescents of both sexes (males, n = 17; females, n = 16; 14 ± 1 years) were randomly assigned into either (i) HL (n = 17): performing 3 sets of 4-6 repetitions to momentary concentric failure; or (ii) LL (n = 16): performing 2 sets of 12-15 repetitions to momentary concentric failure. RT was performed for 2×/week for 9 weeks. Change in maximum strength (1 repetition maximum) and absolute muscular endurance for barbell bench press was assessed. Weekly volume-load was calculated as sets (n) × repetitions (n) × load (kg). Ninety-five percent confidence intervals (CIs) revealed that both groups significantly increased in strength and absolute endurance with large effect sizes (d = 1.51-1.66). There were no between-group differences for change in strength or absolute endurance. Ninety-five percent CIs revealed that both groups significantly increased in weekly volume-load with large effect sizes (HL = 1.66, LL = 1.02). There were no between-group differences for change in volume-load though average weekly volume-load was significantly greater for LL (p strength (r = 0.650, p = 0.005) and absolute endurance (r = 0.552, p = 0.022) increases. Strength and absolute endurance increases do not differ between HL and LL conditions in adolescents when performed to momentary concentric failure. Under HL conditions greater weekly volume-load is associated with greater strength and absolute endurance increases.

  7. The effect of high-frequencies loading on the fatigue cracking of nodular cast iron

    Directory of Open Access Journals (Sweden)

    R. Ulewicz

    2017-01-01

    Full Text Available The article presents the results of fatigue tests using high-frequency loading of nodular cast iron. Nodular cast iron GJS-500-7, GJS-600-3 and cast iron ADI with a tensile strength of Rm = 1 125 MPa were used for the tests. The fatigue tests were conducted on a resonance testing machine. For the cast iron grades under investigation, fatigue characteristics in high and ultra-high-cycle regions were experimentally determined. After the completion of the tests, the fractographic analysis of fatigue fractures was made with the aim of determining the fatigue crack initiation location and the fracture mechanism.

  8. Chilled ceiling and displacement ventilation system: Laboratory study with high cooling load

    OpenAIRE

    Schiavon, S.; Bauman, FS; Tully, B; Rimmer, J

    2015-01-01

    © 2015 ASHRAE.Radiant chilled ceilings with displacement ventilation represent a promising system that combines the energy efficiency of both subsystems with the opportunity for improved ventilation performance. Laboratory experiments were conducted for an interior zone office with a very high cooling load (91.0 W/m2) and with two different heat source heights to investigate their influence on thermal stratification and air change effectiveness. The results showed that displacement ventilatio...

  9. Local Release of Highly Loaded Antibodies from Functionalized Nanoporous Support for Cancer Immunotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Lei, Chenghong; Liu, P.; Chen, Baowei; Mao, Yumeng; Engelmann, Heather E.; Shin, Yongsoon; Jaffar, Jade; Hellstrom, Ingegerd; Liu, Jun; Hellstrom, Karl E.

    2010-05-26

    We report that antibodies can be loaded in functionalized mesoporous silica (FMS) with super-high density to provide long-lasting local release at a given site. Preliminary data indicate that FMS-antibody injected directly into a mouse melanoma induces a greater inhibition of tumor growth than seen in various controls, including the antibody injected intraperitoneally. Our findings introduce a novel approach for local delivery of therapeutically active proteins to tumors and potentially, other diseases.

  10. Advanced thermoplastic composites: An attractive new material for usage in highly loaded vehicle components

    Energy Technology Data Exchange (ETDEWEB)

    Mehn, R.; Seidl, F.; Peis, R.; Heinzmann, D.; Frei, P. [BMW AG Muenchen (Germany)

    1995-10-01

    Beside the lightweight potential and further well known advantages of advanced composite materials, continuous fiber reinforced thermoplastics employed in vehicle structural parts especially offer short manufacturing cycle times and an additional economically viable manufacturing process. Presenting a frame structure concept for two highly loaded vehicle parts, a safety seat and a side door, numerous features concerning the choice of suitable composite materials, design aspects, investigations to develop a thermoforming technique, mature for a series production of vehicle parts, are discussed.

  11. Microbial activities in a vertical-flow wetland system treating sewage sludge with high organic loads

    Energy Technology Data Exchange (ETDEWEB)

    Wang, R. Y.; Perissol, C.; Baldy, V.; Bonin, G.; Korboulewsky, N.

    2009-07-01

    The rhizosphere is the most active zone in treatment wetlands where take place physicochemical and biological processes between the substrate, plants, microorganisms, and contaminants. Microorganisms play the key role in the mineralisation of organic matter. substrate respiration and phosphatase activities (acid and alkaline) were chosen as indicators of microbial activities, and studied in a vertical-flow wetland system receiving sewage sludge with high organic loads under the Mediterranean climate. (Author)

  12. Theoretical research and experimental validation of elastic dynamic load spectra on bogie frame of high-speed train

    Science.gov (United States)

    Zhu, Ning; Sun, Shouguang; Li, Qiang; Zou, Hua

    2016-05-01

    When a train runs at high speeds, the external exciting frequencies approach the natural frequencies of bogie critical components, thereby inducing strong elastic vibrations. The present international reliability test evaluation standard and design criteria of bogie frames are all based on the quasi-static deformation hypothesis. Structural fatigue damage generated by structural elastic vibrations has not yet been included. In this paper, theoretical research and experimental validation are done on elastic dynamic load spectra on bogie frame of high-speed train. The construction of the load series that correspond to elastic dynamic deformation modes is studied. The simplified form of the load series is obtained. A theory of simplified dynamic load-time histories is then deduced. Measured data from the Beijing-Shanghai Dedicated Passenger Line are introduced to derive the simplified dynamic load-time histories. The simplified dynamic discrete load spectra of bogie frame are established. Based on the damage consistency criterion and a genetic algorithm, damage consistency calibration of the simplified dynamic load spectra is finally performed. The computed result proves that the simplified load series is reasonable. The calibrated damage that corresponds to the elastic dynamic discrete load spectra can cover the actual damage at the operating conditions. The calibrated damage satisfies the safety requirement of damage consistency criterion for bogie frame. This research is helpful for investigating the standardized load spectra of bogie frame of high-speed train.

  13. Load balancing in highly parallel processing of Monte Carlo code for particle transport

    Energy Technology Data Exchange (ETDEWEB)

    Higuchi, Kenji; Takemiya, Hiroshi [Japan Atomic Energy Research Inst., Tokyo (Japan); Kawasaki, Takuji [Fuji Research Institute Corporation, Tokyo (Japan)

    2001-01-01

    In parallel processing of Monte Carlo(MC) codes for neutron, photon and electron transport problems, particle histories are assigned to processors making use of independency of the calculation for each particle. Although we can easily parallelize main part of a MC code by this method, it is necessary and practically difficult to optimize the code concerning load balancing in order to attain high speedup ratio in highly parallel processing. In fact, the speedup ratio in the case of 128 processors remains in nearly one hundred times when using the test bed for the performance evaluation. Through the parallel processing of the MCNP code, which is widely used in the nuclear field, it is shown that it is difficult to attain high performance by static load balancing in especially neutron transport problems, and a load balancing method, which dynamically changes the number of assigned particles minimizing the sum of the computational and communication costs, overcomes the difficulty, resulting in nearly fifteen percentage of reduction for execution time. (author)

  14. Light weight design of highly loaded components requires matching load assumptions; Leichtbau hoch beanspruchter Bauteile erfordert angepasste rechnerische Bauteilbemessung

    Energy Technology Data Exchange (ETDEWEB)

    Heinrietz, A.; Ehl, O. [Fraunhofer-Institut fuer Betriebsfestigkeit (LBF), Darmstadt (Germany); Hasselberg, P. [Volvo Truck Corporation (Sweden); Hamm, C.E. [Alfred-Wegener-Institut fuer Polar- und Meeresforschung, Bremerhaven (Germany). Bereich Plankton Biomechanik und Marine Bionik

    2007-07-01

    The aim of safe light weight design requires increasing efforts for component design in the design process. A significant change of the component's topology in order to reach the aim of light weight design may lead to unsafe components, taking customer use into account. The component's light weight shape may become more sensitive to varying operational loads or to varying adjacent components. Computational methods can support the way to light weight design in an efficient way. (orig.)

  15. DM100 AND DM1200 MELTER TESTING WITH HIGH WASTE LOADING GLASS FORMULATIONS FOR HANFORD HIGH-ALUMINUM HLW STREAMS

    Energy Technology Data Exchange (ETDEWEB)

    KRUGER AA; MATLACK KS; KOT WK; PEGG IL; JOSEPH I

    2009-12-30

    This Test Plan describes work to support the development and testing of high waste loading glass formulations that achieve high glass melting rates for Hanford high aluminum high level waste (HLW). In particular, the present testing is designed to evaluate the effect of using low activity waste (LAW) waste streams as a source of sodium in place ofchemical additives, sugar or cellulose as a reductant, boehmite as an aluminum source, and further enhancements to waste processing rate while meeting all processing and product quality requirements. The work will include preparation and characterization of crucible melts in support of subsequent DuraMelter 100 (DM 100) tests designed to examine the effects of enhanced glass formulations, glass processing temperature, incorporation of the LAW waste stream as a sodium source, type of organic reductant, and feed solids content on waste processing rate and product quality. Also included is a confirmatory test on the HLW Pilot Melter (DM1200) with a composition selected from those tested on the DM100. This work builds on previous work performed at the Vitreous State Laboratory (VSL) for Department of Energy's (DOE's) Office of River Protection (ORP) to increase waste loading and processing rates for high-iron HLW waste streams as well as previous tests conducted for ORP on the same waste composition. This Test Plan is prepared in response to an ORP-supplied statement of work. It is currently estimated that the number of HLW canisters to be produced in the Hanford Tank Waste Treatment and Immobilization Plant (WTP) is about 12,500. This estimate is based upon the inventory ofthe tank wastes, the anticipated performance of the sludge treatment processes, and current understanding of the capability of the borosilicate glass waste form. The WTP HLW melter design, unlike earlier DOE melter designs, incorporates an active glass bubbler system. The bubblers create active glass pool convection and thereby improve heat

  16. Dethreading of a Photoactive Azobenzene-Containing Molecular Axle from a Crown Ether Ring: A Computational Investigation.

    Science.gov (United States)

    Tabacchi, Gloria; Silvi, Serena; Venturi, Margherita; Credi, Alberto; Fois, Ettore

    2016-06-17

    Pseudorotaxanes formed by a dibenzo[24]crown-8 ring (R) and a dialkylammonium axle bearing either two E- or two Z-azobenzene units (EE-A or ZZ-A) revealed useful for the construction of light-powered molecular machines and motors, as they provide the opportunity of photocontrolling self-assembly/disassembly processes. The potential energies profiles for the dethreading of these complexes have been investigated by adopting a combination of first-principles molecular dynamics, metadynamics and quantum-chemical geometry optimization approaches. While the dethreading of the EE-A axle is associated with a monotonic energy increase, for that of the ZZ-A axle a transition state and an intermediate structure, in which the components are still threaded together, are found. The rate determining step for the dethreading of the ZZ axle has a higher energy barrier than that of the EE axle, in agreement with the experimental kinetic data. Moreover, the results suggest that the elliptic shape of the ring cavity is important for discriminating between the E and Z terminal azobenzene during dethreading.

  17. Numerical Simulation and Validation of a High Head Model Francis Turbine at Part Load Operating Condition

    Science.gov (United States)

    Goyal, Rahul; Trivedi, Chirag; Kumar Gandhi, Bhupendra; Cervantes, Michel J.

    2017-07-01

    Hydraulic turbines are operated over an extended operating range to meet the real time electricity demand. Turbines operated at part load have flow parameters not matching the designed ones. This results in unstable flow conditions in the runner and draft tube developing low frequency and high amplitude pressure pulsations. The unsteady pressure pulsations affect the dynamic stability of the turbine and cause additional fatigue. The work presented in this paper discusses the flow field investigation of a high head model Francis turbine at part load: 50% of the rated load. Numerical simulation of the complete turbine has been performed. Unsteady pressure pulsations in the vaneless space, runner, and draft tube are investigated and validated with available experimental data. Detailed analysis of the rotor stator interaction and draft tube flow field are performed and discussed. The analysis shows the presence of a rotating vortex rope in the draft tube at the frequency of 0.3 times of the runner rotational frequency. The frequency of the vortex rope precession, which causes severe fluctuations and vibrations in the draft tube, is predicted within 3.9% of the experimental measured value. The vortex rope results pressure pulsations propagating in the system whose frequency is also perceive in the runner and upstream the runner.

  18. HIGH SOLID AND LOW ENZYME LOADING BASED SACCHARIFICATION OF AGRICULTURAL BIOMASS

    Directory of Open Access Journals (Sweden)

    Yu Zhang,

    2011-11-01

    Full Text Available Two agricultural biomass materials, namely wheat straw and sugarcane bagasse, were pretreated with NaOH and then used as substrates for enzymatic saccharification. After the pretreatment, the increase in glucan content and the decrease in lignin content were more than 65%, while less than 20% increase occurred in xylan content. The enzymatic saccharification was initiated with solid loading 9% (w/v, and then 8%, 7% and 6% (w/v solid was fed at 8, 24, and 48 h, respectively. The final enzyme solid loading was 9.60 FPU/g solid and 30% (w/v, respectively. At 144 h, the produced glucose, xylose, and reducing sugar concentrations for wheat straw were 81.88, 20.30, and 115.25 g/L, respectively, and for sugarcane bagasse they were 125.97, 8.66, and 169.50 g/L, respectively. The final conversions of wheat straw and sugarcane bagasse were 34.57% and 50.85%, respectively. SEM images showed that the surface structure of the two materials changed a lot via alkali-pretreatment and enzymatic hydrolysis. In summary, a high concentration sugar is produced from the two agricultural biomass materials by high solid and low enzyme loading. Compared to wheat straw, sugarcane bagasse is more suitable for use in sugar production.

  19. Residual stress in a M3:2 PM high speed steel; effect of mechanical loading

    DEFF Research Database (Denmark)

    Højerslev, Christian; Odén, Magnus; Carstensen, Jesper V.

    2001-01-01

    X-ray lattice strains were investigated in an AISI M3:2 PM high-speed steel in the as heat treated condition and after exposure to alternating mechanical load. The volume changes during heat treatment were monitored with dilatometry. Hardened and tempered AISI M3:2 steel consists of tempered lath...... martensite and the carbides M6C,V8C7 and M23C6. In the as heat treated condition the stress state is triaxial. The primary carbides M6C and V8C7 experience a compressive state of stress. Exposure to an alternating mechanical load, changes the states of stress of V8C7 and tempered martensite, but does...... not appear to change the state of stress in M6C....

  20. Study of stress ratio effect on titanium alloy fatigue under high-frequency loading

    Energy Technology Data Exchange (ETDEWEB)

    Voznyj, T.S.; Gurvich, Yu.V.; Kirillov, V.I.; Troyan, I.A. (AN Ukrainskoj SSR, Kiev. Inst. Problem Prochnosti)

    1983-02-01

    Endurance of two titanium alloys, OT4 type ..cap alpha..-alloy and VT6 martensite class, (..cap alpha..+..beta..)-alloy was studied under symmetric and asymmetric tension-compression at 10 kHz frequency and room temperature using a magnetostriction resonance device. The tests were carried out in the air without water cooling usual in high-frequency tests, since a very low hysteresis dissipation of energy was observed under cyclic loading near the fatigue limit of these titanium alloys. Fatigue curves are obtained on the basis of 10/sup 9/ cycles. The ratio is found for the endurance limit based on 10/sup 7/ and 10/sup 8/ cycles to the ultimate strength under symmetric loading. An equation is given which satisfactorily describes limiting amplitude diagrams, and its coefficients are analyzed.

  1. Assessment of Gearbox Operational Loads and Reliability under High Mean Wind Speeds

    DEFF Research Database (Denmark)

    Dabrowski, Dariusz; Natarajan, Anand

    2015-01-01

    wind turbine that operates in storm conditions with mean wind speeds less than 30 m/s is presented. In the study, normal shut-downs of a wind turbine in storm conditions were investigated. The analysis were conducted for two storm control strategies and different wind conditions from an extreme...... of the model was based on the experimental data provided by NREL for 750 kW prototype gearbox. Failures of gearboxes caused by high dynamic loads have a significant influence on the cost of operation of wind farms. For these reasons in the study, the probability of failure of the gearbox working in an offshore...... operating gust, normal turbulence model and extreme turbulence model. In the paper, loads in the planetary gear are quantified as well as the torsional moments in the main shaft. On the basis of simulation results the annual probability of failure of the gearbox in a wind turbine with soft storm controller...

  2. Design and identification of high performance steel alloys for structures subjected to underwater impulsive loading

    Science.gov (United States)

    Wei, Xiaoding; Latourte, Felix; Feinberg, Zack; Olson, Gregory; Espinosa, Horacio; Micro; Nanomechanics Laboratory Team; Olson Group Team

    2011-06-01

    To characterize the performance of naval structures, underwater blast experiments have been developed. Martensitic and austenitic steel alloys were designed to optimize the performance of structures subjected to impulsive loads. The deformation and fracture characteristics of the designed steel alloys were investigated experimentally and computationally. The experiments were based on an instrumented fluid structure interaction apparatus, in which deflection profiles were recorded. The computational study was based on a modified Gurson damage model able to accurately describe ductile failure under various loading paths. The model was calibrated for two high performance martensitic steels (HSLA-100 and BA-160) and an austenitic steel (TRIP-120). The martensitic steel (BA-160) was designed to maximize strength and fracture toughness while the austenitic steel (TRIP-120) was designed to maximize uniform ductility. The combined experimental-computational approach provided insight into the relationships between material properties and blast resistance of structures.

  3. High-Velocity Impact Behaviour of Prestressed Composite Plates under Bird Strike Loading

    Directory of Open Access Journals (Sweden)

    Sebastian Heimbs

    2012-01-01

    Full Text Available An experimental and numerical analysis of the response of laminated composite plates under high-velocity impact loads of soft body gelatine projectiles (artificial birds is presented. The plates are exposed to tensile and compressive preloads before impact in order to cover realistic loading conditions of representative aeronautic structures under foreign object impact. The modelling methodology for the composite material, delamination interfaces, impact projectile, and preload using the commercial finite element code Abaqus are presented in detail. Finally, the influence of prestress and of different delamination modelling approaches on the impact response is discussed and a comparison to experimental test data is given. Tensile and compressive preloading was found to have an influence on the damage pattern. Although this general behaviour could be predicted well by the simulations, further numerical challenges for improved bird strike simulation accuracy are highlighted.

  4. Automated load balancing in the ATLAS high-performance storage software

    CERN Document Server

    Le Goff, Fabrice; The ATLAS collaboration

    2017-01-01

    The ATLAS experiment collects proton-proton collision events delivered by the LHC accelerator at CERN. The ATLAS Trigger and Data Acquisition (TDAQ) system selects, transports and eventually records event data from the detector at several gigabytes per second. The data are recorded on transient storage before being delivered to permanent storage. The transient storage consists of high-performance direct-attached storage servers accounting for about 500 hard drives. The transient storage operates dedicated software in the form of a distributed multi-threaded application. The workload includes both CPU-demanding and IO-oriented tasks. This paper presents the original application threading model for this particular workload, discussing the load-sharing strategy among the available CPU cores. The limitations of this strategy were reached in 2016 due to changes in the trigger configuration involving a new data distribution pattern. We then describe a novel data-driven load-sharing strategy, designed to automatical...

  5. Biofiltration of xylene using wood charcoal as the biofilter media under transient and high loading conditions.

    Science.gov (United States)

    Singh, Kiran; Giri, B S; Sahi, Amrita; Geed, S R; Kureel, M K; Singh, Sanjay; Dubey, S K; Rai, B N; Kumar, Surendra; Upadhyay, S N; Singh, R S

    2017-10-01

    The main objective of this study was to evaluate the performance of wood charcoal as biofilter media under transient and high loading condition. Biofiltration of xylene was investigated for 150days in a laboratory scale unit packed with wood charcoal and inoculated with mixed microbial culture at the xylene loading rates ranged from 12 to 553gm(-3)h(-1). The kinetic analysis of the xylene revealed absence of substrate inhibition and possibility of achieving higher elimination under optimum condition. The pH, temperature, pressure drop and CO2 production rate were regularly monitored during the experiments. Throughout experimental period, the removal efficiency (RE) was found to be in the range of 65-98.7% and the maximum elimination capacity (EC) was 405.7gm(-3)h(-1). Molecular characterization results show Bacillus sp. as dominating microbial group in the biofilm. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Ionic modified crosslinked salep: a highly loaded and efficient heterogeneous organocatalyst.

    Science.gov (United States)

    Pourjavadi, Ali; Hosseini, Seyed Hassan; Fakoorpoor, Seyed Mahmoud

    2013-02-15

    In this work, a novel heterogeneous organocatalyst was synthesized by immobilization of hydroxide ions on the modified salep as a natural polymer. Because of the grafting of ionic polymer chains onto the salep backbone, catalyst has high loading level of hydroxide ions (3.01 mmol/g). The resulting catalyst shows excellent activity in the synthesis of 4H-benzo[b]pyrans in water at room temperature in short reaction times. The present catalyst and protocol represent a simple, ecologically safe and cost-effective route to synthesize 4H-benzo[b]pyrans with high product yield, as well as easy catalyst recycling.

  7. Effects of Fusion Zone Size and Failure Mode on Peak Load and Energy Absorption of Advanced High Strength Steel Spot Welds under Lap Shear Loading Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Xin; Stephens, Elizabeth V.; Khaleel, Mohammad A.

    2008-06-01

    This paper examines the effects of fusion zone size on failure modes, static strength and energy absorption of resistance spot welds (RSW) of advanced high strength steels (AHSS) under lap shear loading condition. DP800 and TRIP800 spot welds are considered. The main failure modes for spot welds are nugget pullout and interfacial fracture. Partial interfacial fracture is also observed. Static weld strength tests using lap shear samples were performed on the joint populations with various fusion zone sizes. The resulted peak load and energy absorption levels associated with each failure mode were studied for all the weld populations using statistical data analysis tools. The results in this study show that AHSS spot welds with conventionally required fusion zone size of can not produce nugget pullout mode for both the DP800 and TRIP800 welds under lap shear loading. Moreover, failure mode has strong influence on weld peak load and energy absorption for all the DP800 welds and the TRIP800 small welds: welds failed in pullout mode have statistically higher strength and energy absorption than those failed in interfacial fracture mode. For TRIP800 welds above the critical fusion zone level, the influence of weld failure modes on peak load and energy absorption diminishes. Scatter plots of peak load and energy absorption versus weld fusion zone size were then constructed, and the results indicate that fusion zone size is the most critical factor in weld quality in terms of peak load and energy absorption for both DP800 and TRIP800 spot welds.

  8. Cooling performance of grid-sheets for highly loaded ultra-supercritical steam turbines

    Institute of Scientific and Technical Information of China (English)

    Dieter BOHN; Robert KREWINKEL; Shuqing TIAN

    2009-01-01

    In order to increase efficiency and achieve a further CO2-reduction, the next generation of power plant turbines will have steam turbine inlet temperatures that are considerably higher than the current ones. The high pressure steam turbine inlet temperature is expected to be increased up to approximately 700℃ with a live steam pressure of 30 MPa. The elevated steam parameters in the high and intermediate pressure turbines can be encountered with Ni-base alloys, but this is a costly alternative associated with many manufacturing difficulties. Colla-borative research centre 561 "Thermally Highly Loaded,Porous and Cooled Multi-Layer Systems for Combined Cycle Power Plants" at RWTH Aachen University proposes cooling the highly loaded turbines instead, as this would necessitate the application of far less Ni-base alloys.To protect the thermally highly loaded components, a sandwich material consisting of two thin face sheets and a core made from a woven wire mesh is used to cover the walls of the steam turbine casing. The cooling steam is led through the woven wire mesh between the two face sheets to achieve a cooling effect. The wire mesh provides the grid-sheet with structural rigidity under varying operating conditions.In the present work, the cooling performance of the grid-sheets will be investigated applying the conjugate heat transfer method to ultra-supercritical live and cooling steam conditions for a section of the cooling structure. The behaviour of the flow and the heat transfer in the grid-sheet will be analyzed in detail using a parameter variation. The numerical results should give a first prediction of the cooling performance under future operating conditions.

  9. Electrospinning of silver nanoparticles loaded highly porous cellulose acetate nanofibrous membrane for treatment of dye wastewater

    Science.gov (United States)

    Wang, Ke; Ma, Qian; Wang, Shu-Dong; Liu, Hua; Zhang, Sheng-Zhong; Bao, Wei; Zhang, Ke-Qin; Ling, Liang-Zhong

    2016-01-01

    In this paper, silver nanoparticles (NPs) were reduced form silver nitrate. Morphology and distribution of the synthesized silver NPs were characterized. In order to obtain cellulose acetate (CA), nanofibrous membrane with high effective adsorption performance to carry silver NPs for treatment of dye wastewater, different solvent systems were used to fabricate CA nanofibrous membranes with different morphologies and porous structures via electrospinning. Morphologies and structures of the obtained CA nanofibrous membranes were compared by scanning electron microscopy (SEM), which showed that CA nanofibrous membrane obtained from acetone/dichloromethane (1/2, v/v) was with the highly porous structure. SEM, energy-dispersive spectrometry and Fourier transform infrared spectrometry showed that the silver NPs were effectively incorporated in the CA nanofibrous membrane and the addition of silver NPs did not damage the porous structure of the CA nanofibrous membrane. Adsorption of dye solution (rhodamine B aqueous solution) revealed that the highly porous CA nanofibrous membrane exhibited effective adsorption performance and the addition of silver NPs did not affect the adsorption of the dye. Antibacterial property of the CA nanofibrous membrane showed that the silver-loaded highly porous CA nanofibrous membrane had remarkable antibacterial property when compared to the CA nanofibrous membrane without silver NPs. The silver-loaded highly porous CA nanofibrous membrane could be considered as an ideal candidate for treatment of the dye wastewater.

  10. Clinical efficacy of entecavir combined with adefovir in chronic hepatitis B patients with high viral load

    Directory of Open Access Journals (Sweden)

    ZHANG Wen

    2014-11-01

    Full Text Available ObjectiveTo investigate the efficacy and safety of entecavir (ETV combined with adefovir (ADV in chronic hepatitis B (CHB patients with high viral load. MethodsEighty CHB patients with high viral load who were admitted to our hospital from December 2008 to December 2011 were equally and randomly divided into observation group and control group. The control group was given ETV, while the observation group was treated with ETV combined with ADV. HBV DNA load, HBsAg or HBeAg seroconversion, alanine aminotransferase (ALT normalization, and adverse reactions before and after 3, 6, 12, and 24 months of treatment were evaluated. Comparison of continuous data between the two groups was made by independent-samples t test, and comparison of categorical data was made by chi-square test. ResultsCompared with the control group, the observation group had significantly lower HBV DNA load after 6, 12, and 24 months of treatment (3.7±0.3 vs 3.4±0.4 log copies/ml, t=3.339, P<0.05; 2.9±0.4 vs 2.6±0.3 log copies/ml, t=5.657, P<0.05; 1.6±0.7 vs 1.2±0.4 log copies/ml, t=2.806, P<0.05. The HBV DNA clearance rate and HBeAg clearance rate in observation group were significantly higher than those in control group after 12 months of treatment (87.5% vs 70.0%, P<0.05; 80.0% vs 55.0%, P<0.05 and 24 months of treatment (95.0% vs 77.5%, P<0.05; 90.0% vs 70.0%, P<0.05. The observation group had significantly higher HBeAg seroconversion rate and ALT normalization rate than the control group after 24 months of treatment (77.5% vs 50.0%, P<0.05; 82.5% vs 55.0% P<005. During the treatment, there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05, but the observation group had a significantly lower viral breakthrough rate than the control group (0 vs 10.0%, P<0.05. ConclusionFor CHB patients with high viral load, ETV combined with ADV has strong antiviral activity, reduces drug resistance and poor

  11. 基于DEFORM和正交试验法的前轴辊锻工艺优化%Research on optimization of front-axle roll forging technique based on DEFORM-3D and orthogonal experimental method

    Institute of Scientific and Technical Information of China (English)

    魏科; 王高潮; 李宁; 王志录

    2012-01-01

    正交试验主要用于解决科研和生产中多因素、多水平的问题,运用正交试验法可以在减少试验次数的情况下获得最佳的参数组合,可有效节约人力、物力和时间.在DEFORM-3D有限元数值模拟过程中应用正交试验优化设计方法,对前轴制坯辊锻模具弹簧座截面的圆角值、辊锻模具角速度、摩擦因子及坯料初始温度四因素、三水平问题,进行前轴制坯辊锻模具结构及工艺优化研究,分析影响前轴辊锻成形过程中最大成形载荷的因素,研究结果有利于前轴辊锻模具结构及工艺的优化,而且可有效提高辊锻模具的使用寿命.%The structure of front axle roll forging die and the roll forging process were optimized based on orthogonal experimental design method, using DEF0RM-3D software in finite element numerical simulation, adopting three levels and four factors, the latter including the fillet values of the spring seat section of the front axle roll forging die, the angular velocity of the roll forging die, the friction factor and the initial temperature of billets. The effecting factors of maximal forming load in the roll forging process of front axle were analyzed. The results can also increase the service life of roll forging die.

  12. Experimental research on behavior of 460 MPa high strength steel I-section columns under cyclic loading

    Science.gov (United States)

    Wang, Jiaojiao; Shi, Gang; Shi, Yongjiu

    2014-12-01

    To investigate the seismic behavior of I-section columns made of 460 MPa high strength steel (HSS), six specimens were tested under constant axial load and cyclic horizontal load. The specimens were designed with different width-to-thickness ratios and loaded under different axial load ratios. For each specimen, the failure mode was observed and hysteretic curve was measured. Comparison of different specimens on hysteretic characteristic, energy dissipation capacity and deformation capacity were further investigated. Test results showed that the degradation of bearing capacity was due to local buckling of flange and web. Under the same axial load ratio, as width-to-thickness ratio increased, the deformation area of local buckling became smaller. And also, displacement level at both peak load and failure load became smaller. In addition, the full extent of hysteretic curve, energy dissipation capacity, ultimate story drift angle decreased, and capacity degradation occurred more rapidly with the increase of width-to-thickness ratio or axial load ratio. Based on the capacity of story drift angle, limiting values which shall not be exceeded are suggested respectively for flange and web plate of 460 MPa HSS I-section columns when used in SMFs and in IMFs in the case of axial load ratio no more than 0.2. Such values should be smaller when the axial load ratio increases.

  13. Hippocampal NMDA receptors are involved in rats' spontaneous object recognition only under high memory load condition.

    Science.gov (United States)

    Sugita, Manami; Yamada, Kazuo; Iguchi, Natsumi; Ichitani, Yukio

    2015-10-22

    The possible involvement of hippocampal N-methyl-D-aspartate (NMDA) receptors in spontaneous object recognition was investigated in rats under different memory load conditions. We first estimated rats' object memory span using 3-5 objects in "Different Objects Task (DOT)" in order to confirm the highest memory load condition in object recognition memory. Rats were allowed to explore a field in which 3 (3-DOT), 4 (4-DOT), or 5 (5-DOT) different objects were presented. After a delay period, they were placed again in the same field in which one of the sample objects was replaced by another object, and their object exploration behavior was analyzed. Rats could differentiate the novel object from the familiar ones in 3-DOT and 4-DOT but not in 5-DOT, suggesting that rats' object memory span was about 4. Then, we examined the effects of hippocampal AP5 infusion on performance in both 2-DOT (2 different objects were used) and 4-DOT. The drug treatment before the sample phase impaired performance only in 4-DOT. These results suggest that hippocampal NMDA receptors play a critical role in spontaneous object recognition only when the memory load is high.

  14. Transient pressure measurements at part load operating condition of a high head model Francis turbine

    Indian Academy of Sciences (India)

    RAHUL GOYAL; CHIRAG TRIVEDI; B K GANDHI; MICHEL J CERVANTES; OLE G DAHLHAUG

    2016-11-01

    Hydraulic turbines are operating at part load conditions depending on availability of hydraulic energy or to meet the grid requirements. The turbine experiences more fatigue during the part load operating conditions due to flow phenomena such as vortex breakdown in the draft tube and flow instability in the runner.The present paper focuses on the investigation of a high head model Francis turbine operating at 50% load.Pressure measurements have been carried out experimentally on a model Francis turbine. Total six pressure sensors were mounted inside the turbine and other two pressure sensors were mounted at the turbine inlet pipe. It is observed that the turbine experiences significant pressure fluctuations at the vaneless space and the runner.Moreover, a standing wave is observed between the pressure tank outlet and the turbine inlet. Analysis of the data acquired by the pressure sensors mounted in the draft tube showed the presence of vortex breakdown corotating with the runner. The detailed analysis showed the rotating and plunging components of the vortex breakdown. The influence of the rotating component was observed in the entire hydraulic circuit includingdistributor and turbine inlet but not the plunging one.

  15. Charge-Reversal APTES-Modified Mesoporous Silica Nanoparticles with High Drug Loading and Release Controllability.

    Science.gov (United States)

    Wang, Yifeng; Sun, Yi; Wang, Jine; Yang, Yang; Li, Yulin; Yuan, Yuan; Liu, Changsheng

    2016-07-13

    In this study, we demonstrate a facile strategy (DL-SF) for developing MSN-based nanosystems through drug loading (DL, using doxorubicin as a model drug) followed by surface functionalization (SF) of mesoporous silica nanoparticles (MSNs) via aqueous (3-aminopropyl)triethoxysilane (APTES) silylation. For comparison, a reverse functionalization process (i.e., SF-DL) was also studied. The pre-DL process allows for an efficient encapsulation (encapsulation efficiency of ∼75%) of an anticancer drug [doxorubicin (DOX)] inside MSNs, and post-SF allows in situ formation of an APTES outer layer to restrict DOX leakage under physiological conditions. This method makes it possible to tune the DOX release rate by increasing the APTES decoration density through variation of the APTES concentration. However, the SF-DL approach results in a rapid decrease in drug loading capacity with an increase in APTES concentration because of the formation of the APTES outer layer hampers the inner permeability of the DOX drug, resulting in a burst release similar to that of undecorated MSNs. The resulting DOX-loaded DL-SF MSNs present a slightly negatively charged surface under physiological conditions and become positively charged in and extracellular microenvironment of solid tumor due to the protonation effect under acidic conditions. These merits aid their maintenance of long-term stability in blood circulation, high cellular uptake by a kind of skin carcinoma cells, and an enhanced intracellular drug release behavior, showing their potential in the delivery of many drugs beyond anticancer chemotherapeutics.

  16. Particle Concentration and Yield Stress of Biomass Slurries During Enzymatic Hydrolysis at High-Solids Loadings

    Energy Technology Data Exchange (ETDEWEB)

    Roche, C. M.; Dibble, C. J.; Knutsen, J. S.; Stickel, J. J.; Liberatore, M. W.

    2009-01-01

    Effective and efficient breakdown of lignocellulosic biomass remains a primary barrier for its use as a feedstock for renewable transportation fuels. A more detailed understanding of the material properties of biomass slurries during conversion is needed to design cost-effective conversion processes. A series of enzymatic saccharification experiments were performed with dilute acid pretreated corn stover at initial insoluble solids loadings of 20% by mass, during which the concentration of particulate solids and the rheological property yield stress ({tau}{sub y}) of the slurries were measured. The saccharified stover liquefies to the point of being pourable ({tau}{sub y} {le} 10 Pa) at a total biomass conversion of about 40%, after roughly 2 days of saccharification for a moderate loading of enzyme. Mass balance and semi-empirical relationships are developed to connect the progress of enzymatic hydrolysis with particle concentration and yield stress. The experimental data show good agreement with the proposed relationships. The predictive models developed here are based on established physical principles and should be applicable to the saccharification of other biomass systems. The concepts presented, especially the ability to predict yield stress from extent of conversion, will be helpful in the design and optimization of enzymatic hydrolysis processes that operate at high-solids loadings.

  17. Dynamics and Control of High-Rise Buildings under Multidirectional Wind Loads

    Directory of Open Access Journals (Sweden)

    Aly Mousaad Aly

    2011-01-01

    Full Text Available This paper presents a procedure for the response prediction and reduction in high-rise buildings under multidirectional wind loads. The procedure is applied to a very slender tall building that is instructive. The structure is exposed to both cross-wind and along-wind loads obtained from pressure measurements on a rigid model (scaled 1 : 100 that was tested in a wind tunnel with two different configurations of the surroundings. In the theoretical formulation, dynamic equations of the structure are introduced by finite element and 3D lumped mass modeling. The lateral responses of the building in the two directions are controlled at the same time using tuned mass dampers (TMDs and active tuned mass dampers (ATMDs commanded by LQR and fuzzy logic controllers, while the effects of the uncontrolled torsional response of the structure are simultaneously considered. Besides their simplicity, fuzzy logic controllers showed similar trend as LQR controllers under multidirectional wind loads. Nevertheless, the procedure presented in this study can help decision makers, involved in the design process, to choose among innovative solutions like structural control, different damping techniques, modifying geometry, or even changing materials.

  18. Constructing An Event Based Aerosol Product Under High Aerosol Loading Conditions

    Science.gov (United States)

    Levy, R. C.; Shi, Y.; Mattoo, S.; Remer, L. A.; Zhang, J.

    2016-12-01

    High aerosol loading events, such as the Indonesia's forest fire in Fall 2015 or the persistent wintertime haze near Beijing, gain tremendous interests due to their large impact on regional visibility and air quality. Understanding the optical properties of these events and further being able to simulate and predict these events are beneficial. However, it is a great challenge to consistently identify and then retrieve aerosol optical depth (AOD) from passive sensors during heavy aerosol events. Some reasons include:1). large differences between optical properties of high-loading aerosols and those under normal conditions, 2) spectral signals of optically thick aerosols can be mistaken with surface depending on aerosol types, and 3) Extremely optically thick aerosol plumes can also be misidentified as clouds due to its high optical thickness. Thus, even under clear-sky conditions, the global distribution of extreme aerosol events is not well captured in datasets such as the MODIS Dark-Target (DT) aerosol product. In this study, with the synthetic use of OMI Aerosol Index, MODIS cloud product, and operational DT product, the heavy smoke events over the seven sea region are identified and retrieved over the dry season. An event based aerosol product that would compensate the standard "global" aerosol retrieval will be created and evaluated. The impact of missing high AOD retrievals on the regional aerosol climatology will be studied using this newly developed research product.

  19. Flight Loads Prediction of High Aspect Ratio Wing Aircraft Using Multibody Dynamics

    Directory of Open Access Journals (Sweden)

    Michele Castellani

    2016-01-01

    Full Text Available A framework based on multibody dynamics has been developed for the static and dynamic aeroelastic analyses of flexible high aspect ratio wing aircraft subject to structural geometric nonlinearities. Multibody dynamics allows kinematic nonlinearities and nonlinear relationships in the forces definition and is an efficient and promising methodology to model high aspect ratio wings, which are known to be prone to structural nonlinear effects because of the high deflections in flight. The multibody dynamics framework developed employs quasi-steady aerodynamics strip theory and discretizes the wing as a series of rigid bodies interconnected by beam elements, representative of the stiffness distribution, which can undergo arbitrarily large displacements and rotations. The method is applied to a flexible high aspect ratio wing commercial aircraft and both trim and gust response analyses are performed in order to calculate flight loads. These results are then compared to those obtained with the standard linear aeroelastic approach provided by the Finite Element Solver Nastran. Nonlinear effects come into play mainly because of the need of taking into account the large deflections of the wing for flight loads computation and of considering the aerodynamic forces as follower forces.

  20. Release of Inattentional Blindness by High Working Memory Load: Elucidating the Relationship between Working Memory and Selective Attention

    Science.gov (United States)

    de Fockert, Jan W.; Bremner, Andrew J.

    2011-01-01

    An unexpected stimulus often remains unnoticed if attention is focused elsewhere. This inattentional blindness has been shown to be increased under conditions of high memory load. Here we show that increasing working memory load can also have the opposite effect of reducing inattentional blindness (i.e., improving stimulus detection) if stimulus…

  1. Material Surface Damage under High Pulse Loads Typical for ELM Bursts and Disruptions in ITER

    Energy Technology Data Exchange (ETDEWEB)

    Landman, I.S.; Pestchanyi, S.E.; Bazylev, B.N [Forschungszentrum Karlsruhe (Germany). Inst. for Pulsed Power and Microwave Technology; Safronov, V.M. [Troitsk Inst. for Innovation and Fusion Research (TRINITI) (Russian Federation); Garkusha, I.E. [Kharkov Inst. of Physics and Technology (KIPT) (Ukraine). Inst. of Plasma Physics

    2004-08-01

    The divertor armour material for the tokamak ITER will probably be carbon manufactured as fibre composites (CFC) and tungsten as either brush-like structures or thin plates. Disruptive pulse loads where the heat deposition Q may reach 10{sup 2} MJ/m{sup 2} on a time scale {tau} of 3 ms, or operation in the ELMy H-mode at repetitive loads with Q {approx} 3MJ/m{sup 2} and {tau}{approx}0.3 ms; deteriorate armour performance. This work surveys recent numerical and experimental investigations of erosion mechanisms at these off-normal regimes carried out at FZK, TRINITI, and IPP-Kharkov. The modelling uses the anisotropic thermomechanics code PEGASUS-3D for the simulation of CFC brittle destruction, the surface melt motion code MEMOS-1.5D for tungsten targets, and the radiation-magnetohydrodynamics code FOREV-2D for calculating the plasma impact and simulating the heat loads for the ITER regime. Experiments aimed at validating these codes are being carried out at the plasma gun facilities MK-200UG, QSPA-T, and QSPA-Kh50 which produce powerful streams of hydrogen plasma with Q=10-30MJ/m{sup 2} and {tau} = 0.03-0.5 ms. Essential results are, for CFC targets, the experiments at high heat loads and the development of a local overheating model incorporated in PEGASUS-3D, and for the tungsten targets the analysis of evaporation- and melt motion erosion on the base of MEMOS-1.5D calculations for repetitive ELMs.

  2. Effect of various loads on the force-time characteristics of the hang high pull.

    Science.gov (United States)

    Suchomel, Timothy J; Beckham, George K; Wright, Glenn A

    2015-05-01

    The purpose of this study was to investigate the effect of various loads on the force-time characteristics associated with peak power during the hang high pull (HHP). Fourteen athletic men (age: 21.6 ± 1.3 years; height: 179.3 ± 5.6 cm; body mass: 81.5 ± 8.7 kg; 1 repetition maximum [1RM] hang power clean [HPC]: 104.9 ± 15.1 kg) performed sets of the HHP at 30, 45, 65, and 80% of their 1RM HPC. Peak force, peak velocity, peak power, force at peak power, and velocity at peak power were compared between loads. Statistical differences in peak force (p = 0.001), peak velocity (p < 0.001), peak power (p = 0.015), force at peak power (p < 0.001), and velocity at peak power (p < 0.001) existed, with the greatest values for each variable occurring at 80, 30, 45, 80, and 30% 1RM HPC, respectively. Effect sizes between loads indicated that larger differences in velocity at peak power existed as compared with those displayed by force at peak power. It seems that differences in velocity may contribute to a greater extent to differences in peak power production as compared with force during the HHP. Further investigation of both force and velocity at peak power during weightlifting variations is necessary to provide insight on the contributing factors of power production. Specific load ranges should be prescribed to optimally train the variables associated with power development during the HHP.

  3. Antibiotic elution from acrylic bone cement loaded with high doses of tobramycin and vancomycin.

    Science.gov (United States)

    Slane, Joshua; Gietman, Bradley; Squire, Matthew

    2017-09-06

    Two-stage revision treatment of prosthetic joint infection (PJI) frequently employs the use of a temporary bone cement spacer loaded with multiple antibiotic types. Tobramycin and vancomycin are commonly used antibiotics in cement spacers, however, there is no consensus on the relative concentrations and combinations that should be used. Therefore, the purpose of this study was to investigate the influence of dual antibiotic loading on the total antibiotic elution and compressive mechanical properties of acrylic bone cement. Varying concentrations of tobramycin (0-3 g) and vancomycin (0-3 g) were added either alone or in combination to acrylic cement (Palacos R), resulting in 12 experimental groups. Samples were submerged in 37°C saline for 28 d and sampled at specific time points. The collected eluent was analyzed to determine the cumulative antibiotic release. In addition, the cement's compressive mechanical properties and porosity were characterized. Interestingly, the cement with the highest concentration of antibiotics did not possess the best elution properties. Cement samples containing both 3 g of tobramycin and 2 g vancomycin demonstrated the highest cumulative antibiotic release after 28 d, which was coupled with a significant decrease in the mechanical properties and an increased porosity. The collected data also suggests that tobramycin elutes more effectively than vancomycin from cement. In conclusion, this study demonstrates that high antibiotic loading in cement does not necessarily lead to enhanced antibiotic elution. Clinically this information may be used to optimize cement spacer antibiotic loading so that both duration and amount of antibiotics eluted are optimized. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  4. Development of high drug-loading nanomicelles targeting steroids to the brain.

    Science.gov (United States)

    Zheng, Sijia; Xie, Yanqi; Li, Yuan; Li, Ling; Tian, Ning; Zhu, Wenbo; Yan, Guangmei; Wu, Chuanbin; Hu, Haiyan

    2014-01-01

    The objective of this research was to develop and evaluate high drug-loading ligand-modified nanomicelles to deliver a steroidal compound to the brain. YC1 (5α-cholestane-24-methylene-3β, 5α, 6β, 19-tetraol), with poor solubility and limited access to the brain, for the first time, has been proved to be an effective neuroprotective steroid by our previous studies. Based on the principle of 'like dissolves like', cholesterol, which shares the same steroidal parent nucleus with YC1, was selected to react with sodium alginate, producing amphiphilic sodium alginate- cholesterol derivatives (SACDs). To increase the grafting ratio and drug loading, cholesterol was converted to cholesteryl chloroformate, for the first time, before reacting with sodium alginate. Further, lactoferrin was conjugated on SACDs to provide lactoferrin-SACDs (Lf-SACD), which was established by immune electron microscopy (IEM) and self-assembled into brain-targeting nanomicelles. These nanomicelles were negatively charged and spherical in nature, with an average size of drug loading was increased due to the cholesteryl inner cores of the nanomicelles, and the higher the grafting ratio was, the lower the critical micelle concentration (CMC) value of SACD, and the higher drug loading. The in vitro drug release, studied by bulk-equilibrium dialysis in 20 mL of 6% hydroxypropyl-β-cyclodextrin solution at 37°C, indicated a prolonged release profile. The YC1 concentration in mouse brain delivered by lactoferrin-modified nanomicelles was higher than in those delivered by non-modified nanomicelles and YC1 solution. The unique brain-targeting nanomicelle system may provide a promising carrier to deliver hydrophobic drugs across the blood-brain barrier for the treatment of brain diseases.

  5. Material Surface Damage under High Pulse Loads Typical for ELM Bursts and Disruptions in ITER

    Science.gov (United States)

    Landman, I. S.; Pestchanyi, S. E.; Safronov, V. M.; Bazylev, B. N.; Garkusha, I. E.

    The divertor armour material for the tokamak ITER will probably be carbon manufactured as fibre composites (CFC) and tungsten as either brush-like structures or thin plates. Disruptive pulse loads where the heat deposition Q may reach 102 MJ/m 2 on a time scale Ïä of 3 ms, or operation in the ELMy H-mode at repetitive loads with Q âe 1/4 3 MJ/m2 and Ïä âe 1/4 0.3 ms, deteriorate armour performance. This work surveys recent numerical and experimental investigations of erosion mechanisms at these off-normal regimes carried out at FZK, TRINITI, and IPP-Kharkov. The modelling uses the anisotropic thermomechanics code PEGASUS-3D for the simulation of CFC brittle destruction, the surface melt motion code MEMOS-1.5D for tungsten targets, and the radiation-magnetohydrodynamics code FOREV-2D for calculating the plasma impact and simulating the heat loads for the ITER regime. Experiments aimed at validating these codes are being carried out at the plasma gun facilities MK-200UG, QSPA-T, and QSPA-Kh50 which produce powerful streams of hydrogen plasma with Q = 10–30 MJ/m2 and Ïä = 0.03–0.5 ms. Essential results are, for CFC targets, the experiments at high heat loads and the development of a local overheating model incorporated in PEGASUS-3D, and for the tungsten targets the analysis of evaporation- and melt motion erosion on the base of MEMOS-1.5D calculations for repetitive ELMs.

  6. A Method for Load Frequency Control using Battery in Power System with Highly Penetrated Photovoltaic Generation

    Science.gov (United States)

    Nagoya, Hiroyuki; Komami, Shintaro; Ogimoto, Kazuhiko

    It is generally believed that a large amount of battery system will be needed to store surplus electric energy due to high penetration of renewable energy (RE) such as photovoltaic generation (PV). Since main objective of high penetration of REs is to reduce amount of CO2 emission, reducing kWh output of thermal generation that does emit large amount of CO2 in power system should be considered sufficiently. However, thermal generation takes a important role in load frequency control (LFC) of power system. Therefore, if LFC could be done with battery and hydro generation, kWh output of thermal generation would be reduced significantly. This paper presents a method for LFC using battery in power system with highly penetrated PVs. Assessment of the effect of the proposed method would be made considering mutual smoothing effect of highly penetrated PVs.

  7. A high sensitivity wireless mass-loading surface acoustic wave DNA biosensor

    Science.gov (United States)

    Cai, Hua-Lin; Yang, Yi; Zhang, Yi-Han; Zhou, Chang-Jian; Guo, Cang-Ran; Liu, Jing; Ren, Tian-Ling

    2014-03-01

    In this paper, a surface acoustic wave (SAW) biosensor with gold delay area on LiNbO3 substrate detecting DNA sequences is proposed. By well-designed device parameters of the SAW sensor, it achieves a high performance for highly sensitive detection of target DNA. In addition, an effective biological treatment method for DNA immobilization and abundant experimental verification of the sensing effect have made it a reliable device in DNA detection. The loading mass of the probe and target DNA sequences is obtained from the frequency shifts, which are big enough in this work due to an effective biological treatment. The experimental results show that the biosensor has a high sensitivity of 1.2 pg/ml/Hz and high selectivity characteristic is also verified by the few responses of other substances. In combination with wireless transceiver, we develop a wireless receiving and processing system that can directly display the detection results.

  8. Progressive high-load strength training compared with general low-load exercises in patients with rotator cuff tendinopathy: study protocol for a randomised controlled trial.

    Science.gov (United States)

    Ingwersen, Kim G; Christensen, Robin; Sørensen, Lilli; Jørgensen, Hans Ri; Jensen, Steen Lund; Rasmussen, Sten; Søgaard, Karen; Juul-Kristensen, Birgit

    2015-01-27

    Shoulder pain is the third most common musculoskeletal disorder, often affecting people's daily living and work capacity. The most common shoulder disorder is the subacromial impingement syndrome (SIS) which, among other pathophysiological changes, is often characterised by rotator cuff tendinopathy. Exercise is often considered the primary treatment option for rotator cuff tendinopathy, but there is no consensus on which exercise strategy is the most effective. As eccentric and high-load strength training have been shown to have a positive effect on patella and Achilles tendinopathy, the aim of this trial is to compare the efficacy of progressive high-load exercises with traditional low-load exercises in patients with rotator cuff tendinopathy. The current study is a randomised, participant- and assessor-blinded, controlled multicentre trial. A total of 260 patients with rotator cuff tendinopathy will be recruited from three outpatient shoulder departments in Denmark, and randomised to either 12 weeks of progressive high-load strength training or to general low-load exercises. Patients will receive six individually guided exercise sessions with a physiotherapist and perform home-based exercises three times a week. The primary outcome measure will be change from baseline to 12 weeks in the patient-reported outcome Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire. Previous studies of exercise treatment for SIS have not differentiated between subgroups of SIS and have often had methodological flaws, making it difficult to specifically design target treatment for patients diagnosed with SIS. Therefore, it was considered important to focus on a subgroup such as tendinopathy, with a specific tailored intervention strategy based on evidence from other regions of the body, and to clearly describe the intervention in a methodologically strong study. The trial was registered with Clinicaltrials.gov ( NCT01984203 ) on 31 October 2013.

  9. Temperature calculations of heat loads in rotating target wheels exposed to high beam currents.

    Energy Technology Data Exchange (ETDEWEB)

    Greene, J. P.; Gabor, R.; Neubauer, J.

    2000-11-29

    In heavy-ion physics, high beam currents can eventually melt or destroy the target. Tightly focused beams on stationary targets of modest melting point will exhibit short lifetimes. Defocused or wobbled beams are employed to enhance target survival. Rotating targets using large diameter wheels can help overcome target melting and allow for higher beam currents to be used in experiments. The purpose of the calculations in this work is to try and predict the safe maximum beam currents which produce heat loads below the melting point of the target material.

  10. Influence of different SSF conditions on ethanol production from corn stover at high solids loadings

    DEFF Research Database (Denmark)

    Gladis, Arne; Bondesson, Pia-Maria; Galbe, Mats

    2015-01-01

    In this study, three different kinds of simultaneous saccharification and fermentation (SSF) of washed pretreated corn stover with water-insoluble solids (WIS) content of 20% were investigated to find which one resulted in highest ethanol yield at high-solids loadings. The different methods were...... batch SSF, prehydrolysis followed by batch SSF and fed-batch SSF. Batch-SSF resulted in an ethanol yield of 75-76% and an ethanol concentration of 53 g/L. Prehydrolysis prior to batch SSF did not improve the ethanol yield compared with batch SSF. Fedbatch SSF, on the other hand, increased the yield...

  11. Online Load Operating Mode of Oil Film Bearing in High Speed Wire Rolling Mill

    Institute of Scientific and Technical Information of China (English)

    LI Yugui; PANG Siqing; HUANG Qingxue; WANG Jianmei; ZHAO Chunjiang

    2006-01-01

    To study the mechanism of burnt damage of oil film bearing in high-speed wire rolling mill, reasonable temperature sensors are designed and calibrated, pressure block of rolling mill has been transformed into pressure sensors. Online temperature and load of oil film bearing in a domestic precision rolling F15 have been tested. Consequently, a large sum of valuable test data was obtained. The distributions rules of pressure and temperature under continuous online rolling state are recorded in detail. Theoretical and experimental results are beneficial to damage mechanism of oil film bearing, thus its service life could be prolonged. Moreover, such results could provide an important reference for online test and control.

  12. On the performance of circular concrete-filled high strength steel columns under axial loading

    Directory of Open Access Journals (Sweden)

    Mohamed Mahmoud El-Heweity

    2012-06-01

    Full Text Available This work presents a numerical study to investigate the performance of circular high-strength steel tubes filled with concrete (CFT under monotonic axial loading. A model is developed to implement the material constitutive relationships and non-linearity. Calibration against previous experimental data shows good agreement. A parametric study is then conducted using the model and compared with codes provisions. Strength and ductility of confined concrete are of primary concern. Variables considered are yield stress of steel tube and column diameter. The assessment of column performance is based on axial load carrying capacities and enhancements of both strength and ductility due to confinement. Two parameters namely strength enhancement factor (Kf and ductility index (μ are clearly defined and introduced for assessment. Results indicate that both concrete strength and ductility of CFT columns are enhanced but to different extents. The ductile behaviors are significantly evident. The increase in yield stress of steel tube has a minimal effect on concrete strength but pronounced effect on concrete ductility. However, reduction in ductility is associated with using high-tensile steel of Grade 70. The overall findings indicate that the use of high-strength tube in CFT columns is not promising. This finding may seriously be considered in seismic design.

  13. CO2–CH4 permeation in high zeolite 4A loading mixed matrix membranes

    KAUST Repository

    Adams, Ryan T.

    2011-02-01

    Mixed matrix membranes (MMMs) with low particle loadings have been shown to improve the properties of pure polymers for many gas separations. Comparatively few reports have been made for high particle loading (≥50vol.%) MMMs. In this work, CO2-CH4 feeds were used to study the potential of 50vol.% zeolite 4A-poly(vinyl acetate) (PVAc) MMMs for natural gas separations. A low CO2 partial pressure mixed feed probed MMM performance below the plasticization pressure of PVAc and a high CO2 partial pressure mixed feed probed MMM performance at industrially relevant conditions above the plasticization pressure.Under both mixed feed conditions at 35°C, substantial improvements in overall separation performance were observed. At low CO2 partial pressures, CO2 permeability roughly doubled with a nearly 50% increase in selectivity versus pure PVAc under the same conditions. For the high CO2 partial pressure feed, CO2 permeability remained effectively unchanged with a 63% increase in selectivity versus pure PVAc. Surprisingly, the performance of these PVAc based MMMs approached the properties of current " upper bound" polymers. Overall, this work shows that significantly improved performance MMMs can be made with traditional techniques from a low cost, low performance polymer without costly adhesion promoters. © 2010.

  14. Evolution of the fracture process zone in high-strength concrete under different loading rates

    Directory of Open Access Journals (Sweden)

    Cámara M.

    2010-06-01

    Full Text Available For cementitious materials, the inelastic zone around a crack tip is termed as fracture process zone (FPZ and dominated by complicated mechanism, such as microcracking, crack deflection, bridging, crack face friction, crack tip blunting by voids, crack branching, and so on. Due to the length of the FPZ is related with the characteristic length of the cementitious materials, the size, extent and location of the FPZ has been the object of countless research efforts for several decades. For instance, Cedolin et al. [1] have used an optical method based on the moiré interferometry to determine FPZ in concrete. Castro-Montero et al. [2] have applied the method of holographic interferometry to mortar to study the extension of the FPZ. The advantage of the interferometry method is that the complete FPZ can be directly observed on the surface of the sample. Swartz et al. [3] has adopted the dye penetration technique to illustrate the changing patterns observed as the crack progress from the tensile side to the compression side of the beam. Moreover, acoustic emission (AE is also an experimental technique well suited for monitoring fracture process. Haidar et al. [4] and Maji et al. [5] have studied the relation between acoustic emission characteristics and the properties of the FPZ. Compared with the extensive research on properties of the FPZ under quasi-static loading conditions, much less information is available on its dynamic characterization, especially for high-strength concrete (HSC. This paper presents the very recent results of an experimental program aimed at disclosing the loading rate effect on the size and velocity of the (FPZ in HSC. Eighteen three-point bending specimens were conducted under a wide range of loading rates from from 10-4 mm/s to 103 mm/s using either a servo-hydraulic machine or a self-designed drop-weight impact device. The beam dimensions were 100 mm 100 mm in cross section, and 420 mm in length. The initial notch

  15. Microwave-assisted synthesis of high-loading, highly dispersed Pt/carbon aerogel catalyst for direct methanol fuel cell

    Indian Academy of Sciences (India)

    Zhijun Guo; Hong Zhu; Xinwei Zhang; Fanghui Wang; Yubao Guo; Yongsheng Wei

    2011-06-01

    A Pt supported on carbon aerogel catalyst has been synthesized by the microwave-assisted polyol process. The Pt supported on carbon aerogel catalyst was characterized by high resolution transmission electron microscopy and X-ray diffraction. The results show a uniform dispersion of spherical Pt nanoparticles 2.5–3.0 nm in diameter. Cyclic voltammetry and chronoamperometry were used to evaluate the electrocatalytic activity of the Pt/carbon aerogel catalyst for methanol oxidation at room temperature. The Pt/carbon aerogel catalyst shows higher electrochemical catalytic activity and stability for methanol oxidation than a commercial Pt/C catalyst of the same Pt loading.

  16. The Effect of Predeparture Training Loads on Posttour Physical Capacities in High-Performance Junior Tennis Players.

    Science.gov (United States)

    Murphy, Alistair P; Duffield, Rob; Kellett, Aaron; Gescheit, Dani; Reid, Machar

    2015-11-01

    Difficulties in preserving physical capacities while on tennis tours necessitate targeted training prescription. This study analyzed training and match loads performed before and on tour for their relationship with posttour physical-capacity changes. A secondary aim was to determine whether the presence of a strength and conditioning (S&C) coach affected the type and volume of on-tour training load. The training and match loads of 30 high-performance junior tennis players were recorded over 8 wk: 4 wk before and 4 wk during an international tour. Fitness tests were conducted pretour and posttour, including double and single-leg (dominant and nondominant) countermovement jump, speed (5, 10, and 20 m), modified 5-0-5 agility, 10 × 20-m repeated-sprint ability, and multistage fitness tests. Tour training and match loads were categorized according to whether S&C support was present or absent. Total and tennis training loads were significantly greater on tour than pretour (P ≤ .05, d > 0.8). Increases in on-tour, on-court training loads were moderately correlated with decrements in speed and aerobic power (r = .31-.52). Finally, S&C presence on tour significantly increased total, on-court, and off-court training load completed (P ≤ .05, d > 0.8). Training loads should be carefully prescribed to ensure that sufficient total and tennis loads are completed pretour. Specifically, speed and aerobic capacities may regress with increased training on tour. Finally, a practical observation was that on-tour S&C support resulted in increased S&C training load (around match loads), potentially countering the observed regression of physical capacities. Such a finding has the capacity to alter current physical-preparation structures in high-performance tennis environments with finite resources.

  17. Eradication of high viable loads of Listeria monocytogenes contaminating food-contact surfaces

    Directory of Open Access Journals (Sweden)

    Silvia ede Candia

    2015-07-01

    Full Text Available This study demonstrates the efficacy of cold gaseous ozone treatments at low concentrations in the eradication of high Listeria monocytogenes viable cell loads from glass, polypropylene, stainless steel and expanded polystyrene food-contact surfaces. Using a step by step approach, involving the selection of the most resistant strain-surface combinations, 11 Listeria spp. strains resulted inactivated by a continuous ozone flow at 1.07 mg m-3 after 24 or 48 h of cold incubation, depending on both strain and surface evaluated. Increasing the inoculum level to 9 log CFU coupon-1, the best inactivation rate was obtained after 48h of treatment at 3.21 mg m-3 ozone concentration when cells were deposited onto stainless steel and expanded polystyrene coupons, resulted the most resistant food-contact surfaces in the previous assays.The addition of naturally microbiologically contaminated meat extract to a high load of L. monocytogenes LMG 23775 cells, the most resistant strain out of the 11 assayed Listeria spp. strains, led to its complete inactivation after four days of treatment.To the best of our knowledge, this is the first report describing the survival of L. monocytogenes and the effect of ozone treatment under cold storage conditions on expanded polystyrene, a commonly-used material in food packaging. These results could be useful for reducing pathogen cross-contamination phenomena during cold food storage.

  18. Core-shell nanocarriers with high paclitaxel loading for passive and active targeting

    Science.gov (United States)

    Jin, Zhu; Lv, Yaqi; Cao, Hui; Yao, Jing; Zhou, Jianping; He, Wei; Yin, Lifang

    2016-06-01

    Rapid blood clearance and premature burst release are inherent drawbacks of conventional nanoparticles, resulting in poor tumor selectivity. iRGD peptide is widely recognized as an efficient cell membrane penetration peptide homing to αVβ3 integrins. Herein, core-shell nanocapsules (NCs) and iRGD-modified NCs (iRGD-NCs) with high drug payload for paclitaxel (PTX) were prepared to enhance the antitumor activities of chemotherapy agents with poor water solubility. Improved in vitro and in vivo tumor targeting and penetration were observed with NCs and iRGD-NCs; the latter exhibited better antitumor activity because iRGD enhanced the accumulation and penetration of NCs in tumors. The NCs were cytocompatible, histocompatible, and non-toxic to other healthy tissues. The endocytosis of NCs was mediated by lipid rafts in an energy-dependent manner, leading to better cytotoxicity of PTX against cancer cells. In contrast with commercial product, PTX-loaded NCs (PTX-NCs) increased area under concentration-time curve (AUC) by about 4-fold, prolonged mean resident time (MRT) by more than 8-fold and reduced the elimination rate constant by greater than 68-fold. In conclusion, the present nanocarriers with high drug-loading capacity represent an efficient tumor-targeting drug delivery system with promising potential for cancer therapy.

  19. High organic loading treatment for industrial molasses wastewater and microbial community shifts corresponding to system development.

    Science.gov (United States)

    Kuroda, Kyohei; Chosei, Tomoaki; Nakahara, Nozomi; Hatamoto, Masashi; Wakabayashi, Takashi; Kawai, Toshikazu; Araki, Nobuo; Syutsubo, Kazuaki; Yamaguchi, Takashi

    2015-11-01

    Molasses wastewater contains high levels of organic compounds, cations, and anions, causing operational problems for anaerobic biological treatment. To establish a high organic loading treatment system for industrial molasses wastewater, this study designed a combined system comprising an acidification tank, a thermophilic multi-stage (MS)-upflow anaerobic sludge blanket (UASB) reactor, mesophilic UASB reactor, and down-flow hanging sponge reactor. The average total chemical oxygen demand (COD) and biochemical oxygen demand removal rates were 85%±3% and 95%±2%, respectively, at an organic loading rate of 42kgCODcrm(-3)d(-1) in the MS-UASB reactor. By installation of the acidification tank, the MS-UASB reactor achieved low H2-partial pressure. The abundance of syntrophs such as fatty acid-degrading bacteria increased in the MS-UASB and 2nd-UASB reactors. Thus, the acidification tank contributed to maintaining a favorable environment for syntrophic associations. This study provides new information regarding microbial community composition in a molasses wastewater treatment system. Copyright © 2015. Published by Elsevier Ltd.

  20. A high-power switch-mode dc power supply for dynamic loads

    Energy Technology Data Exchange (ETDEWEB)

    Shimer, D.W.; Lange, A.C. [Lawrence Livermore National Lab., CA (United States); Bombay, J.N. [Kaiser Engineers, Oakland, CA (United States)

    1994-06-23

    High-voltage dc power supplies are often required to operate with highly dynamic loads, such as arcs. A switch-mode dc power supply can offer significant advantages over conventional thyristor-based dc power supplies under such conditions. It can quickly turn off the supply to extinguish the arc, and it can quickly recover after the arc. It has a relatively small output filter capacitance, which results in small stored energy available to the arc. A 400-kW, 50-kV switch-mode dc power supply for an electron-beam gun that exploits these advantages was designed and tested. It uses four 100-kW, current-source-type dc-dc converters with inputs in parallel and outputs in series. The dc-dc converters operate at 20 kHz in the voltage regulator part and 10 kHz in the inverter, transformer, and output rectifier part of the circuit. Insulated gate bipolar transistors (IGBTs) are used as the power switches. Special techniques are used to protect the power supply and load against arcs and hard shorts. The power supply has an efficiency of 93%, an output voltage ripple of 1%, and fast dynamic response. In addition, it is nearly one-third the size of conventional power supplies.

  1. The role of superconductivity in magnetic bearings for high-load applications

    Science.gov (United States)

    Downer, James; Eisenhaure, David

    1993-01-01

    Slewing of large payloads will require control torque and angular momentum storage capacities that are large in comparison to the capabilities of available control moment gyros (CMG's). SatCon Technology Corporation is currently designing a CMG which may be employed as a slew actuator for large spacecraft or other payloads. The slew actuator employs a type of magnetic bearing which may be used in high load applications. The magnetic bearing is also used to fully gimbal the suspended rotor of the slew actuator. The use of magnetic bearings in angular momentum exchange actuators has the primary advantage that physical contact between the rotor and stator is eliminated. This leads to greatly extended life, increased reliability, and reduced vibrations. Several actuators operating on magnetic bearings have been demonstrated in previous research efforts. These were sized for use in small satellites. For conventional magnetic bearings, which employ magnetic cores, high torsional loading may require that the magnetic structure be excessively massive. An alternative magnetic bearing design which employs a superconducting coil and eliminates conventional magnetic structures is discussed. The baseline approach is to replace the field coil of a conventional magnetic bearing with the superconducting coil.

  2. Hybrid Robust Control Law with Disturbance Observer for High-Frequency Response Electro-Hydraulic Servo Loading System

    Directory of Open Access Journals (Sweden)

    Zhiqing Sheng

    2016-04-01

    Full Text Available Addressing the simulating issue of the helicopter-manipulating booster aerodynamic load with high-frequency dynamic load superimposed on a large static load, this paper studies the design of the robust controller for the electro-hydraulic loading system to realize the simulation of this kind of load. Firstly, the equivalent linear model of the electro-hydraulic loading system under assumed parameter uncertainty is established. Then, a hybrid control scheme is proposed for the loading system. This control scheme consists of a constant velocity feed-forward compensator, a robust inner loop compensator based on disturbance observer and a robust outer loop feedback controller. The constant velocity compensator eliminates most of the extraneous force at first, and then the double-loop cascade composition control strategy is employed to design the compensated system. The disturbance observer–based inner loop compensator further restrains the disturbances including the remaining extraneous force, and makes the actual plant tracking a nominal model approximately in a certain frequency range. The robust outer loop controller achieves the desired force-tracking performance, and guarantees system robustness in the high frequency region. The optimized low-pass filter Q(s is designed by using the H∞ mixed sensitivity optimization method. The simulation results show that the proposed hybrid control scheme and controller can effectively suppress the extraneous force and improve the robustness of the electro-hydraulic loading system.

  3. Intelligent Energy Management Strategy for a Separated-Axle Parallel Hybrid Electric Vehicle

    Directory of Open Access Journals (Sweden)

    Naser Fallahi

    2014-03-01

    Full Text Available Hybrid electric vehicles (HEV in addition to provide the benefits of electric vehicles could satisfy consumers for some performances of conventional internal combustion engine (ICE vehicles such as acceleration and long range. On this way, suitable energy optimization strategies should be employed to get desired efficiency, less fuel consumption and pollution. One of the favorite and simple configurations of HEVs is parallel type. A student team at University of Kashan, IRAN have designed and manufactured Shaheb 2 hybrid electric vehicle. It is a separated-axle (or Through-to-Road (TTR parallel HEV type based on Pride platform. Employed energy management in Shaheb 2 is on/off strategy and three modes; motor, engine and hybrid have been implemented. This paper investigates the modeling of separated-axle (or TTR parallel type of HEV in ADVISOR software and then evaluates two control strategies for Shaheb 2; on/off strategy and an intelligent control based on fuzzy logic. On this way, maximizing the engine is considered as objective function. The simulation results indicate that the fuzzy strategy leads to less fuel consumption and lower pollution for given UDDS driving cycle rather than on/off strategy for Shaheb 2.

  4. POD curves for non-maximizable ultrasonic responses: Statistical derivation and application to solid freight axles

    Science.gov (United States)

    Carboni, Michele; Cantini, Stefano

    2016-02-01

    The most relevant standards on ultrasonic testing, and an effective inspection practice, require the maximization of echo responses due to indications before their evaluation in terms of amplitude and size. This is achieved effectively pointing the acoustic axis of the sound beam to the indication, in a way to get back the maximum possible sound energy. Considering some operative cases, however, such a response maximization is not always feasible, mainly due to geometrical constraints impeding the inspection of the whole control area with a constant sensitivity. The traditional end inspection of solid railway axles by a rotating probe mounting conventional sensors falls back into this kind of inspections. In particular, inspection angles are fixed and the probe holder cannot move along the axle allowing response maximization of in-service damages located, for example, along the cylindrical body. It follows some control areas cannot be inspected using the maximum sound pressure. The present research shows how the derivation of "Probability of Detection" curves for non-maximizable ultrasonic responses cannot be carried out by the traditional statistical approach and a novel one, of the "Model-Assisted Probability of Detection" kind, is consequently proposed based on experiments and numerical simulations.

  5. Stiffness determination of the controlled wheel module of a two-axle vehicle

    Directory of Open Access Journals (Sweden)

    Belevtseva N.V.

    2016-08-01

    Full Text Available The conditions of a secure loss of stability of a two-axle wheel vehicle with absolutely hard steering have been found before. The analytically derived conditions of a secure stability loss in case of torsional stiffness are dependent on the relationship between the slipping resistance coefficients, the transverse clutch coefficients on the axes, and the torsional stiffness of the controlled wheel module. In this case, the trail distance is taken into account in the wheel module control system, the mass of the module being neglected. The approach suggested in the paper does take into account the mass of the controlled wheel module. The slipping forces are presented accurate to a cubic term of expansion in slipping angles. The torsional stiffness intervals have been found that provide a secure loss of stability of a two-axle wheel vehicle model. The intervals have been obtained on the basis of a bifurcation analysis of actual bifurcations of the stationary states in the vicinity of the rectilinear motion of the model. Diagrams that illustrate the fulfillment of secure stability loss conditions and allow using the results obtained in designing a wheel module are presented in the paper. The technique used is alternative to the well-known M. Bautin’s approach to determination of secure-insecure conditions in case of a divergent loss of stability.

  6. Rapid room temperature solubilization and depolymerization of polymeric lignin at high loadings

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Jian; Dutta, Tanmoy; Parthasarathi, Ramakrishnan; Kim, Kwang Ho; Tolic, Nikola; Chu, Rosalie K.; Isern, Nancy G.; Cort, John R.; Simmons, Blake A.; Singh, Seema

    2016-10-03

    The relatively poor solubility of lignin in most pretreatment solvents remains one of the biggest challegnes in lignin valorization to improve overall biorefinery economics. In this work, rapid room temperature solubilization of lignin at high solid loadings (>30 wt%) can be easily achieved in a single step using ethylene glycol (EG). The solubilized lignin can be rapidly and quantitively recovered with the addtion of ethanol. The computational and nuclear magnetic resonance (NMR) spectroscopic studies confirm that strong hydrogen bond interactions between EG and the free hydroxyl groups present in lignin contribute to the lignin dissolution. In addition, hydrogen peroxide mediated depolymerization of dissolved lignin at low temperature (80 oC) was tested and the effect of EG molecules on depolymerization of ligin was also theoritically studied. The findings of this work provide mechanistic insights of hydrogen bond interactions in high lignin solubilization and valorization.

  7. Application of high-resolution domestic electricity load profiles in network modelling

    DEFF Research Database (Denmark)

    Marszal, Anna Joanna; Mendaza, Iker Diaz de Cerio; Heiselberg, Per Kvols

    2016-01-01

    % of buildings, the loading of the transformer and power lines is reduced in the summer time to 58% and 51%, respectively. However, the power lines are stress with bi-directional power flow. The results indicate that the business-as-usual approach to network modeling is not sufficient to capture......The ongoing development towards electrification of the energy consumption together with large deployment of renewable energy sources creates new challenges of variability and fluctuation of the electricity supply and increases complexity of the network operation. In order to capture all...... the particularities of electricity demand and on-site generation, e.g. the short-term spikes due use of high electricity consumption appliances such like electric kettle, and get a full picture of network performance, a high-resolution input data are needed. This paper compares the business-as-usual network modeling...

  8. Estimated environmental loads of alpha-amylase from transgenic high-amylase maize

    Energy Technology Data Exchange (ETDEWEB)

    Wolt, Jeffrey D. [Department of Agronomy, Iowa State University, Ames, IA 50011 (United States); Biosafety Institute for Genetically Modified Agricultural Products, 164 Seed Science, Iowa State University, Ames, IA 50011 (United States); Karaman, Sule [Biosafety Institute for Genetically Modified Agricultural Products, 164 Seed Science, Iowa State University, Ames, IA 50011 (United States)

    2007-11-15

    Environmental exposure of plants bioengineered to improve efficiencies of biofuel production is an important consideration for their adoption. High-amylase maize genetically engineered to produce thermostable alpha-amylase in seed endosperm is currently in development, and its successful adoption will entail >1000 km{sup 2} of annual production in the USA. Environmental exposure of thermostable amylase will occur in production fields from preharvest and harvest dropped grain, with minor additional contributions from stover and root biomass. Mass loadings of thermostable alpha-amylase are projected to be 16 kg km{sup -2} and represent a potential source of increased alpha-amylase activity in receiving soils. An understanding of the degradation, persistence, accumulation, and activity of thermostable alpha-amylase introduced from transgenic high-amylase maize will be necessary in order to effectively manage transgenic crop systems intended or biofeedstock production. (author)

  9. The cryogenic cooling program in high-heat-load optics at the Advanced Photon Source

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, C.S.

    1993-07-01

    This paper describes some of the aspects of the cryogenic optics program at the Advanced Photon Source (APS). A liquid-nitrogen-cooled, high-vacuum, double crystal monochromator is being fabricated at Argonne National Laboratory (ANL). A pumping system capable of delivering a variable flow rate of up to 10 gallons per minute of pressurized liquid nitrogen and removing 5 kilowatts of x-ray power is also being constructed. This specialized pumping system and monochromator will be used to test the viability of cryogenically cooled, high-heat-load synchrotron optics. It has been determined that heat transfer enhancement will be required for optics used with APS insertion devices. An analysis of a porous-matrix-enhanced monochromator crystal is presented. For the particular case investigated, a heat transfer enhancement factor of 5 to 6 was calculated.

  10. Cost optimization of load carrying thin-walled precast high performance concrete sandwich panels

    DEFF Research Database (Denmark)

    Hodicky, Kamil; Hansen, Sanne; Hulin, Thomas

    2015-01-01

    and HPCSP’s geometrical parameters as well as on material cost function in the HPCSP design. Cost functions are presented for High Performance Concrete (HPC), insulation layer, reinforcement and include labour-related costs. The present study reports the economic data corresponding to specific manufacturing......The paper describes a procedure to find the structurally and thermally efficient design of load-carrying thin-walled precast High Performance Concrete Sandwich Panels (HPCSP) with an optimal economical solution. A systematic optimization approach is based on the selection of material’s performances....... The solution of the optimization problem is performed in the computer package software Matlab® with SQPlab package and integrates the processes of HPCSP design, quantity take-off and cost estimation. The proposed optimization process outcomes in complex HPCSP design proposals to achieve minimum cost of HPCSP....

  11. Load management strategy for Particle-In-Cell simulations in high energy physics

    CERN Document Server

    Beck, Arnaud; Derouillat, Julien

    2015-01-01

    In the wake of the intense effort made for the experimental CILEX project, numerical simulation campaigns have been carried out in order to finalize the design of the facility and to identify optimal laser and plasma parameters. These simulations bring, of course, important insight into the fundamental physics at play. As a by-product, they also characterize the quality of our theoretical and numerical models. By comparing the results given by different codes, it is possible to point out algorithmic limitations both in terms of physical accuracy and computational performances. In this paper we illustrate some of these limitations in the context of electron laser wakefield acceleration (LWFA). The main limitation we identify in state-of-the-art Particle-In-Cell (PIC) codes is computational load imbalance. We propose an innovative algorithm to deal with this specific issue as well as milestones towards a modern, accurate high-performance PIC code for high energy physics.

  12. Load management strategy for Particle-In-Cell simulations in high energy particle acceleration

    Science.gov (United States)

    Beck, A.; Frederiksen, J. T.; Dérouillat, J.

    2016-09-01

    In the wake of the intense effort made for the experimental CILEX project, numerical simulation campaigns have been carried out in order to finalize the design of the facility and to identify optimal laser and plasma parameters. These simulations bring, of course, important insight into the fundamental physics at play. As a by-product, they also characterize the quality of our theoretical and numerical models. In this paper, we compare the results given by different codes and point out algorithmic limitations both in terms of physical accuracy and computational performances. These limitations are illustrated in the context of electron laser wakefield acceleration (LWFA). The main limitation we identify in state-of-the-art Particle-In-Cell (PIC) codes is computational load imbalance. We propose an innovative algorithm to deal with this specific issue as well as milestones towards a modern, accurate high-performance PIC code for high energy particle acceleration.

  13. Turbulence Resolving Flow Simulations of a Francis Turbine in Part Load using Highly Parallel CFD Simulations

    Science.gov (United States)

    Krappel, Timo; Riedelbauch, Stefan; Jester-Zuerker, Roland; Jung, Alexander; Flurl, Benedikt; Unger, Friedeman; Galpin, Paul

    2016-11-01

    The operation of Francis turbines in part load conditions causes high fluctuations and dynamic loads in the turbine and especially in the draft tube. At the hub of the runner outlet a rotating vortex rope within a low pressure zone arises and propagates into the draft tube cone. The investigated part load operating point is at about 72% discharge of best efficiency. To reduce the possible influence of boundary conditions on the solution, a flow simulation of a complete Francis turbine is conducted consisting of spiral case, stay and guide vanes, runner and draft tube. As the flow has a strong swirling component for the chosen operating point, it is very challenging to accurately predict the flow and in particular the flow losses in the diffusor. The goal of this study is to reach significantly better numerical prediction of this flow type. This is achieved by an improved resolution of small turbulent structures. Therefore, the Scale Adaptive Simulation SAS-SST turbulence model - a scale resolving turbulence model - is applied and compared to the widely used RANS-SST turbulence model. The largest mesh contains 300 million elements, which achieves LES-like resolution throughout much of the computational domain. The simulations are evaluated in terms of the hydraulic losses in the machine, evaluation of the velocity field, pressure oscillations in the draft tube and visual comparisons of turbulent flow structures. A pre-release version of ANSYS CFX 17.0 is used in this paper, as this CFD solver has a parallel performance up to several thousands of cores for this application which includes a transient rotor-stator interface to support the relative motion between the runner and the stationary portions of the water turbine.

  14. Influence of high glycemic index and glycemic load diets on blood pressure during adolescence.

    Science.gov (United States)

    Gopinath, Bamini; Flood, Victoria M; Rochtchina, Elena; Baur, Louise A; Smith, Wayne; Mitchell, Paul

    2012-06-01

    We aimed to prospectively examine the association between the glycemic index and glycemic load of foods consumed and the dietary intakes of carbohydrates, sugars, fiber, and principal carbohydrate-containing food groups (eg, breads, cereals, and sugary drinks) with changes in blood pressure during adolescence. A total of 858 students aged 12 years at baseline (422 girls and 436 boys) were examined from 2004-2005 to 2009-2011. Dietary data were assessed from validated semiquantitative food frequency questionnaires. Blood pressure was measured using a standard protocol. In girls, after adjusting for age, ethnicity, parental education, parental history of hypertension, baseline height, baseline blood pressure, change in body mass index, and time spent in physical and sedentary activities, each 1-SD (1-SD = 7.10 g/d) increase in baseline dietary intake of total fiber was associated with a 0.96-, 0.62-, and 0.75-mmHg decrease in mean systolic (P = 0.02), diastolic (P = 0.01), and arterial blood pressures (P = 0.002), respectively, 5 years later. In girls, each 1-SD increase in dietary glycemic index, glycemic load, carbohydrate, and fructose was concurrently related to increases of 1.81 (P = 0.001), 4.02 (P = 0.01), 4.74 (P = 0.01), and 1.80 mm Hg (P = 0.03) in systolic blood pressure, respectively, >5 years. Significant associations between carbohydrate nutrition variables and blood pressure were not observed among boys. Excessive dietary intake of carbohydrates, specifically from high glycemic index/glycemic load foods, could adversely influence blood pressure, particularly in girls, whereas fiber-rich diets may be protective against elevated blood pressure during adolescence.

  15. The effects of varying resistance-training loads on intermediate- and high-velocity-specific adaptations.

    Science.gov (United States)

    Jones, K; Bishop, P; Hunter, G; Fleisig, G

    2001-08-01

    The purpose of this study was to compare changes in velocity-specific adaptations in moderately resistance-trained athletes who trained with either low or high resistances. The study used tests of sport-specific skills across an intermediate- to high-velocity spectrum. Thirty NCAA Division I baseball players were randomly assigned to either a low-resistance (40-60% 1 repetition maximum [1RM]) training group or a high-resistance (70-90% 1RM) training group. Both of the training groups intended to maximallv accelerate each repetition during the concentric phase (IMCA). The 10 weeks of training consisted of 4 training sessions a week using basic core exercises. Peak force, velocity, and power were evaluated during set angle and depth jumps as well as weighted jumps using 30 and 50% 1RM. Squat 1RMs were also tested. Although no interactions for any of the jump tests were found, trends supported the hypothesis of velocity-specific training. Percentage gains suggest that the combined use of heavier training loads (70-90% 1RM) and IMCA tend to increase peak force in the lower-body leg and hip extensors. Trends also show that the combined use of lighter training loads (40-60% 1RM) and IMCA tend to increase peak power and peak velocity in the lower-body leg and hip extensors. The high-resistance group improved squats more than the low-resistance group (p IMCA to increase 1RM strength in the lower bodies of resistance-trained athletes.

  16. Analysis of Unsteady Tip and Endwall Heat Transfer in a Highly Loaded Transonic Turbine Stage

    Science.gov (United States)

    Shyam, Vikram; Ameri, Ali; Chen, Jen-Ping

    2010-01-01

    In a previous study, vane-rotor shock interactions and heat transfer on the rotor blade of a highly loaded transonic turbine stage were simulated. The geometry consists of a high pressure turbine vane and downstream rotor blade. This study focuses on the physics of flow and heat transfer in the rotor tip, casing and hub regions. The simulation was performed using the Unsteady Reynolds-Averaged Navier-Stokes (URANS) code MSU-TURBO. A low Reynolds number k-epsilon model was utilized to model turbulence. The rotor blade in question has a tip gap height of 2.1 percent of the blade height. The Reynolds number of the flow is approximately 3x10(exp 6) per meter. Unsteadiness was observed at the tip surface that results in intermittent "hot spots". It is demonstrated that unsteadiness in the tip gap is governed by inviscid effects due to high speed flow and is not strongly dependent on pressure ratio across the tip gap contrary to published observations that have primarily dealt with subsonic tip flows. The high relative Mach numbers in the tip gap lead to a choking of the leakage flow that translates to a relative attenuation of losses at higher loading. The efficacy of new tip geometry is discussed to minimize heat flux at the tip while maintaining choked conditions. In addition, an explanation is provided that shows the mechanism behind the rise in stagnation temperature on the casing to values above the absolute total temperature at the inlet. It is concluded that even in steady mode, work transfer to the near tip fluid occurs due to relative shearing by the casing. This is believed to be the first such explanation of the work transfer phenomenon in the open literature. The difference in pattern between steady and time-averaged heat flux at the hub is also explained.

  17. Polyamidoamine dendrimer-based binders for high-loading lithium–sulfur battery cathodes

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharya, Priyanka; Nandasiri, Manjula I.; Lv, Dongping; Schwarz, Ashleigh M.; Darsell, Jens T.; Henderson, Wesley A.; Tomalia, Donald A.; Liu, Jun; Zhang, Ji-Guang; Xiao, Jie

    2016-01-01

    Lithium-sulfur (Li-S) batteries are regarded as one of the most promising candidates for next generation energy storage systems because of their ultra high theoretical specific energy. To realize the practical application of Li-S batteries, however, a high S active material loading is essential (>70 wt% in the carbon-sulfur (C-S) composite cathode and >2 mg cm-2 in the electrode). A critical challenge to achieving this high capacity in practical electrodes is the dissolution of the longer lithium polysulfide reaction intermediates in the electrolyte (resulting in loss of active material from the cathode and contamination of the anode due to the polysulfide shuttle mechanism). The binder material used for the cathode is therefore crucial as this is a key determinant of the bonding interactions between the active material (S) and electronic conducting support (C), as well as the maintenance of intimate contact between the electrode materials and current collector. The battery performance can thus be directly correlated with the choice of binder, but this has received only minimal attention in the relevant Li-S battery published literature. Here, we investigated the application of polyamidoamine (PAMAM) dendrimers as functional binders in Li-S batteries—a class of materials which has been unexplored for electrode design. By using dendrimers, it is demonstrated that high S loadings (>4 mg cm-2) can be easily achieved using "standard" (not specifically tailored) materials and simple processing methods. An exceptional electrochemical cycling performance was obtained (as compared to cathodes with conventional linear polymeric binders such as carboxymethyl cellulose (CMC) and styrene-butadiene rubber (SBR)) with >100 cycles and 85-98% capacity retention, thus demonstrating the significant utility of this new binder architecture which exhibits critical physicochemical properties and flexible nanoscale design parameters (CNDP's).

  18. High Pt Loading on Polydopamine Functionalized Graphene as a High Performance Cathode Electrocatalyst for Proton Exchange Membrane Fuel Cells

    Directory of Open Access Journals (Sweden)

    Monireh Faraji

    2016-04-01

    Full Text Available Morphology and size of platinum nanoparticles are a crucial factor in improving their catalytic activity and stability. Here, we firstly report the synthesis of high loading Pt nanoparticles on polydopamine reduced Graphene. The loading concentration of Pt (nanoparticles NPs on Graphene can be adjusted in the range of 60-70%.With the insertion of polydopamine between Graphene oxide sheets, stacking of Graphene can be effectively prevented, promoting diffusion of oxygen molecules through the Graphene sheets and enhancing the oxygen reduction reaction electrocatalytic activity. Compared to commercial catalysts (i.e., state-of-the-art Pt/C catalyst the as synthesized Pt supported polydopamine grafted reduced graphite oxide (Pt@PDA-rGO hybrid displays very high oxygen reduction reaction catalytic activities. We propose a unique 2D profile of the polydopamine-rGO role as a barrier preventing leaching of Pt into the electrolyte. The fabricated electrodes were evaluated with electrochemical techniques for oxygen reduction reaction and the obtained results were further verified by the transmission electron microscopy micrographs on the microstructure of the integrated pt@PDA-rGO structures. It has been revealed that the electrochemical impedance spectroscopy technique can provide more explicit information than polarization curves on the performance dependence on charge-transfer and mass transport processes at different overpotential regions.

  19. Preparation of HCPT-Loaded Nanoneedles with Pointed Ends for Highly Efficient Cancer Chemotherapy

    Science.gov (United States)

    Wu, Shichao; Yang, Xiangrui; Li, Yang; Wu, Hongjie; Huang, Yu; Xie, Liya; Zhang, Ying; Hou, Zhenqing; Liu, Xiangyang

    2016-06-01

    The high-aspect-ratio nanoparticles were proved to be internalized much more rapidly and efficiently by cancer cells than the nanoparticles with an equal aspect ratio. Herein, a kind of high-aspect ratio, pointed-end nanoneedles (NDs) with a high drug loading (15.04 %) and the prolonged drug release profile were fabricated with an anti-tumor drug—10-hydroxycamptothecin (HCPT)—via an ultrasound-assisted emulsion crystallization technique. It is surprising to see that the cellular internalization of NDs with an average length of 5 μm and an aspect ratio of about 12:1 was even much faster and higher than that of nanorods with the same size and the nanospheres with a much smaller size of 150 nm. The results further validated that cellular internalization of the nanoparticles exhibited a strong shape-dependent effect, and cellular uptake may favor the particles with sharp ends as well as a high-aspect ratio instead of particle size. The NDs with enhanced cytotoxicity would lead to a promising sustained local drug delivery system for highly efficient anticancer therapy. More importantly, the fabrication of NDs opens a door to design new formulations of nanoneedle drug delivery systems for highly efficient cancer.

  20. ITER-W monoblocks under high pulse number transient heat loads at high temperature

    Energy Technology Data Exchange (ETDEWEB)

    Loewenhoff, Th., E-mail: T.Loewenhoff@fz-juelich.de [Forschungszentrum Jülich, 52428 Jülich (Germany); Linke, J., E-mail: J.Linke@fz-juelich.de [Forschungszentrum Jülich, 52428 Jülich (Germany); Pintsuk, G., E-mail: G.Pintsuk@fz-juelich.de [Forschungszentrum Jülich, 52428 Jülich (Germany); Pitts, R.A., E-mail: Richard.Pitts@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul-Lez-Durance (France); Riccardi, B., E-mail: Bruno.Riccardi@f4e.europa.eu [Fusion for Energy Joint Undertaking, Josep Pla No. 2 – T B3 7/01, Barcelona 08019 (Spain)

    2015-08-15

    In the context of using a full-tungsten (W) divertor for ITER, thermal shock resistance has become even more important as an issue that may potentially influence the long term performance. To address this issue a unique series of experiments has been performed on ITER-W monoblock mock ups in three EU high heat flux facilities: GLADIS (neutral beam), JUDITH 2 (electron beam) and Magnum-PSI (plasma beam). This paper discusses the JUDITH 2 experiments. Two different base temperatures, 1200 °C and 1500 °C, were chosen superimposed by ∼18,000/100,000 transient events (Δt = 0.48 ms) of 0.2 and 0.6 GW/m{sup 2}. Results showed a stronger surface deterioration at higher base temperature, quantified by an increase in roughening. This is intensified if the same test is done after preloading (exposure to high temperature without transients), especially at higher base temperature when the material recrystallizes.

  1. High-intensity tasks with external load in military applications: a review.

    Science.gov (United States)

    O'Neal, Eric K; Hornsby, Jared H; Kelleran, Kyle J

    2014-09-01

    This article provides a synopsis of the limited investigations examining the impact of external load (EL) on performance of high-intensity tasks under load (HITL), EL training intervention effects on HITL performance, and injuries from EL training. Repetitive lifting tasks and initiation of locomotion, such as rapidly moving from a prone position to sprinting appear to be more hindered by EL than maximal sprinting velocity and may explain why training with EL does not improve obstacle course or prolonged (200-300 yard shuttle) drills. EL training appears to offer very little if any benefit for HITL in lesser trained populations. This contrast results of multiple studies incorporating ≥ 3 weeks of prolonged hypergravity interventions (wearing EL during daily activities) in elite anaerobic athletes, indicating EL training stimulus is likely only beneficial to well-trained soldiers. Women and lesser trained individuals appear to be more susceptible to increased injury with EL training. A significant limitation concerning current HITL knowledge is the lack of studies incorporating trained soldiers. Future investigations concerning the effects of HITL on marksmanship, repetitive lifting biomechanics, efficacy of hypergravity training for military personnel, and kinematics of sprinting from tactical positions with various EL displacements and technique training are warranted.

  2. Detection of high biliary and fecal viral loads in patients with chronic hepatitis C virus infection.

    Science.gov (United States)

    Monrroy, Hugo; Angulo, Jenniffer; Pino, Karla; Labbé, Pilar; Miquel, Juan Francisco; López-Lastra, Marcelo; Soza, Alejandro

    2017-05-01

    The life cycle of the hepatitis C virus (HCV) is closely associated with lipid metabolism. Recently, NPC1L1 (a cholesterol transporter) has been reported to function as an HCV receptor. This receptor is expressed in the hepatocyte canalicular membrane and in the intestine; serving as a key transporter for the cholesterol enterohepatic cycle. We hypothesized that HCV might have a similar cycle, so we aimed to study the presence of HCV in bile and stools of infected patients. Blood, feces, and duodenal bile samples were collected from patients infected with HCV. The biliary viral load was normalized to the bile salt concentration of each sample and the presence of HCV core protein was also evaluated. A total of 12 patients were recruited. HCV RNA was detected in the bile from ten patients. The mean viral load was 2.5log10IU/60mg bile salt. In the stool samples, HCV RNA was detected in ten patients (mean concentration 2.7log10IU/g of feces). HCV RNA is readily detectable and is present at relatively high concentrations in the bile and stool samples of infected patients. This may be relevant as a source of infection in men who have sex with men. Biliary HCV secretion may perhaps play a role in the persistence of viral infection via an enterohepatic cycle of the virus or intrahepatic spread. Copyright © 2017 Elsevier España, S.L.U., AEEH y AEG. All rights reserved.

  3. Simplified formulations with high drug loads for continuous twin-screw granulation.

    Science.gov (United States)

    Meier, R; Thommes, M; Rasenack, N; Krumme, M; Moll, K-P; Kleinebudde, P

    2015-12-30

    As different batches of the same excipients will be intermixed during continuous processes, the traceability of batches is complicated. Simplified formulations may help to reduce problems related to batch intermixing and traceability. Twin-screw granulation with subsequent tableting was used to produce granules and tablets, containing drug, disintegrant and binder (binary and ternary mixtures), only. Drug loads up to 90% were achieved and five different disintegrants were screened for keeping their disintegration suitability after wetting. Granule size distributions were consistently mono-modal and narrow. Granule strength reached higher values, using ternary mixtures. Tablets containing croscarmellose-Na as disintegrant displayed tensile strengths up to 3.1MPa and disintegration times from 400 to 466s, resulting in the most robust disintegrant. Dissolution was overall complete and above 96% within 30 min. Na-starch glycolate offers tensile strengths up to 2.8MPa at disintegration times from 25s to 1031s, providing the broadest application window, as it corresponds in some parts to different definitions of orodispersible tablets. Tablets containing micronized crospovidone are not suitable for immediate release, but showed possibilities to produce highly drug loaded, prolonged release tablets. Tablets and granules from simplified formulations offer great opportunities to improve continuous processes, present performances comparable to more complicated formulations and are able to correspond to requirements of the authorities.

  4. Corner Separation Control by Boundary Layer Suction Applied to a Highly Loaded Axial Compressor Cascade

    Directory of Open Access Journals (Sweden)

    Yangwei Liu

    2014-11-01

    Full Text Available Control of corner separation has attracted much interest due to its improvement of performance and energy utilization in turbomachinery. Numerical studies have been performed under both design and off-design flow conditions to investigate the effects of boundary layer suction (BLS on corner separation in a highly loaded compressor cascade. Two new BLS slot configurations are proposed and a total of five suction slot configurations were studied and compared. Averaged static pressure rise, exit loss coefficient, passage blockage and flow turning angle have been given and compared systematically over a range of operation incidence angles. Distributions of significant loss removal, blade loading, exit deviation and total pressure loss at 3 degree and 7 degree incidence have also been studied. Under the same suction mass flows of 0.7% of the inlet mass flows, the pitchwise suction slot on the endwall shows a better optimal performance over the whole operation incidence among single suction slots. By using of the new proposed compound slot configuration with one spanwise slot on the blade suction side and one pitchwise slot on the endwall, the maximum reduction of total pressure loss at 7 degree incidence can be 39.4%.

  5. A Developed Methodology in Design of Highly Loaded Tandem Axial Flow Compressor Stage

    Directory of Open Access Journals (Sweden)

    Masoud Boroomand

    2016-01-01

    Full Text Available This study, primarily reports the development of a 3D design procedure for axial flow tandem compressor stages and then the method is used to design a highly loaded tandem stage. In order to investigate the effects of such arrangement, another stage with conventional loading with single blade for both rotor and stator rows is designed with similar specification. In order to ease the comparison of results, chord lengths and hub/shroud geometries are selected with the same dimensions. At the next stage a three dimensional numerical model is developed to predict the characteristic performance of both tandem and conventional stages. The model is validated with the experimental results of NASA-67 stage and the level of the accuracy of the model is presented. Employing the model to simulate the performance of both stages at design and offdesign operating points show that, tandem stage can provide higher pressure ratio with acceptable efficiency. In another word, tandem stage is capable having the same pressure ratio at lower rotational speed. The safe operation domain and loss mechanism in tandem stage are also discussed in this report.

  6. Behavior of Brazed W/Cu Mockup Under High Heat Flux Loads

    Science.gov (United States)

    Chen, Lei; Lian, Youyun; Liu, Xiang

    2014-03-01

    In order to transfer the heat from the armor to the coolant, tungsten has to be connected with a copper heat sink. The joint technology is the most critical issue for manufacturing plasma facing components. Consequently, the reliability of the joints should be verified by a great number of high-heat-flux (HHF) tests to simulate the real load conditions. W/Cu brazed joint technology with sliver free filler metal CuMnNi has been developed at Southwestern Institute of Physics (SWIP). Screening and thermal fatigue tests of one small-scale flat tile W/CuCrZr mockup were performed on a 60 kW electron-beam Material testing scenario (EMS-60) constructed recently at SWIP. The module successfully survived screening test with the absorbed power density (Pabs) of 2 MW/m2 to 10 MW/m2 and the following 1000 cycles at Pabs of 7.2 MW/m2 without hot spots and overheating zones during the whole test campaign. Metallurgy and SEM observations did not find any cracks at both sides and the interface, indicating a good bonding of W and CuCrZr alloy. In addition, finite element simulations by ANSYS 12.0 under experimental load conditions were performed and compared with experimental results.

  7. EFFECTS OF SLOTTED BLADING ON SECONDARY FLOW IN HIGHLY LOADED COMPRESSOR CASCADE

    Directory of Open Access Journals (Sweden)

    RAMZI MDOUKI

    2013-10-01

    Full Text Available With the aim to increase allowable blade loadings and enlarge stable operating range in highly loaded compressor, this work is carried out in order to explore the potential of passive control via slotted bladings in linear cascade configurations under both design and stall conditions. Through an extensive 2D-numerical study, the effects of location, width and slope of slots were analysed and the best configuration was identified. Based on the optimal slot, the 3D aerodynamic performances of cascade were studied and the influence of slotted blading to control endwall flow was investigated. Both 2D and 3D calculations are performed on steady RANS solver with standard k-epsilon turbulence model and low Mach number regime. The total loss coefficient, turning angle and flow visualizations on the blade and end-wall surfaces are adopted to describe the different configurations. The obtained results show, for 2D situation, that a maximum of 28.3% reduction in loss coefficient had been reached and the flow turning was increased with approximately 5°. Concerning 3D flow fields the slots marked their benefit at large incoming flow angles which delays the separation on both end wall and blade suction surface at mid span. However, at design conditions, the slotted blades are not able to control secondary flows near the wall and so, lose their potential.

  8. FEATURES OF PERCEPTION OF LOADING ELEMENTS OF THE RAILWAY TRACK AT HIGH SPEEDS OF THE MOVEMENT

    Directory of Open Access Journals (Sweden)

    D. M. Kurhan

    2015-03-01

    Full Text Available Purpose. Increase the train speeds movements requires not only the appropriate technical solutions, but also methodological-calculated. Most of the models and methodologies used for solving problems of stress-strain state of the railroad tracks, are based on assumptions and hypotheses adequate only for certain speeds. In the framework of this work will be discussed theoretical background of the changing nature of perceptual load elements of the railway track at high speeds and investigated the numeric parameters of the processes by means of mathematical modeling. As a practical purposes is expected to provide the levels of train speed, the boundaries of which can reasonably exclude the possibility of occurrence of the considered effects. Methodology. To achieve these objectives was used principal new model of railway track based on wave propagation theory stresses in the elastic system to study the impact of the movable load, take into account that the deflection in a particular section of the road starts even while the wheels at some distance, and moving the wheels farther from the selected section of the wave front elastic strain continues to spread. According to the results of simulations explores the changing shape of the wave front voltages in time for the foundation under the rail. If the train speeds substantially less than the velocity propagation of elastic waves, the wheel remains in the area implemented deformations. Findings. Alternative calculations for various parameters of the railway track (especially for different soil conditions determined the levels of train speed, the boundaries of which can reasonably exclude the possibility of occurrence of the considered effects. Originality. The proposed theoretical study and implementation in the form of mathematical models for processes that occur in the perception of load elements of the railway track at high speeds. Practical value. According to simulation results obtained levels of

  9. NEW APPROACH FOR TECHNOLOGY OF VOLUMETRIC – SUPERFICIAL HARDENING OF GEAR DETAILS OF THE BACK AXLE OF MOBILE MACHINES

    Directory of Open Access Journals (Sweden)

    A. I. Mihluk

    2010-01-01

    Full Text Available The new approach for technology of volumetric – superficial hardening of gear details of the back axle made of steel lowered harden ability is offered. This approach consisting in formation of intense – hardened condition on all surface of a detail.

  10. The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target

    NARCIS (Netherlands)

    Koorstra, Jan-Bart M.; Karikari, Collins A.; Feldmann, Georg; Bisht, Savita; Rojas, Pamela Leal; Offerhaus, G. Johan A.; Alvarez, Hector; Maitra, Anirban

    2009-01-01

    Background: Pancreatic cancer is a near uniformly lethal disease and a better understanding of the molecular basis of this malignancy may lead to improved therapeutics. The Axl receptor tyrosine kinase is implicated in cellular transformation and tumor progression, although its role in pancreatic

  11. Evaluation by respirometry of the loading capacity of a high rate vermicompost bed for treating sewage sludge.

    Science.gov (United States)

    Clarke, William P; Taylor, Michael; Cossins, Rowan

    2007-09-01

    This study examines high rate vermicomposting of sewage sludge using high stocking densities of earthworms. To examine the loading capacity, two vermicompost beds were established in identical 0.84 m diameter reactors, one loaded at an average rate of 10 kg-wet-sludge-mixture m(-2) day(-1) (0.5 kg-carbon m(-2) day(-1)), the other loaded at 20 kg-wet-sludge-mixture m(-2) day(-1) (1 kg-carbon m(-2) day(-1)). The sludge mixture was from a commercial vermicomposting company (Vermitech) and contained 80-90% sludge and 10-20% green waste and clay. The beds were operated in fed-batch mode for 38 days, and then monitored for a further 12 days without any further sludge loading. Earthworms (Eisenia fetida) were added once or twice weekly over the 38 days loading period to gradually decrease the ratio of sludge loading rate to total earthworm biomass. By adding earthworm incrementally, the feeding rate ranged from 3.9 to 1.25 kg-wet-sludge kg-earthworm(-1) day(-1) for the full load experiment and 2-0.62 kg-wet-sludge kg-earthworm(-1) day(-1) for the half load experiment. The extent of degradation was estimated by fitting a 1st order model to the CO2 production rate from the beds. Based on the 1st order model, 53+/-20% (95% CI) and 68+/-4% of the organic carbon was converted to CO2 -C in the full load and half load experiments respectively. The CO2 production rate in the half load experiment became stable and repeatable when the total earthworm biomass reached 5.4 kg, corresponding to a feed rate of 1.04 kg-wet-sludge-mixture kg-earthworm(-1) day(-1). In contrast, the rate of CO2 production was still climbing and traces of methane were evident in the full load experiment at the end of the 38 day loading period. The experiments indicate that high rate vermicomposting beds are sustainable providing the feeding rate does not exceed approximately 1 kg-wet-sludge kg-earthworm(-1) day(-1).

  12. Reinstating lead for high-loaded efficient negative electrode for rechargeable sodium-ion battery

    Science.gov (United States)

    Darwiche, Ali; Dugas, Romain; Fraisse, Bernard; Monconduit, Laure

    2016-02-01

    Due to its weight and toxicity, Pb is usually not considered as possible anode for Li- and Na-ion (NIBs) batteries. Nevertheless the toxicity is related to specific applications and its recycling is more than 99% which is one of the highest recycling rates on the planet where no other power source is utilized in more applications with such sustainability. For this reason, we have investigated micrometric lead particles as electrode for NIBs in an ether-based electrolyte (1 M NaPF6 in diglyme). The cyclability, coulombic efficiency and rate capability of lead were unexpected. A high loaded lead electrode with 98%wt of Pb and only 1% of carbon additive showed i) a capacity retention of 464 mA h/g after 50 cycles with only 1.5% of capacity loss, which represents a high volumetric capacity of 5289 mA h/cm3 due to the high density of Pb and ii) a very interesting capacity retention even at high current rate (1950 mA/g). In situ XRD study confirmed a sodiation-desodiation process in four steps. Preliminary tests in Pb//Na3V2(PO4)2F3 full cells showed promising results demonstrating that Pb could be a practical candidate for future high energy density Na-ion batteries with an efficient sodiated or non sodiated positive electrode.

  13. A Short-Term and High-Resolution System Load Forecasting Approach Using Support Vector Regression with Hybrid Parameters Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Huaiguang [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-08-25

    This work proposes an approach for distribution system load forecasting, which aims to provide highly accurate short-term load forecasting with high resolution utilizing a support vector regression (SVR) based forecaster and a two-step hybrid parameters optimization method. Specifically, because the load profiles in distribution systems contain abrupt deviations, a data normalization is designed as the pretreatment for the collected historical load data. Then an SVR model is trained by the load data to forecast the future load. For better performance of SVR, a two-step hybrid optimization algorithm is proposed to determine the best parameters. In the first step of the hybrid optimization algorithm, a designed grid traverse algorithm (GTA) is used to narrow the parameters searching area from a global to local space. In the second step, based on the result of the GTA, particle swarm optimization (PSO) is used to determine the best parameters in the local parameter space. After the best parameters are determined, the SVR model is used to forecast the short-term load deviation in the distribution system.

  14. Multi-mode controller IC for soft-switched flyback converter with high efficiency over the entire load range

    Institute of Scientific and Technical Information of China (English)

    Hai CHEN; Meng-lian ZHAO; Xiao-bo WU; Xiao-lang YAN

    2008-01-01

    This paper presents a multi-mode control scheme for a soft-switched flyback converter to achieve high efficiency and excellent load regulation over the entire load range. At heavy load, critical conduction mode with valley switching (CCMVS) is employed to realize soft switching so as to reduce turn-on loss of power switch as well as conducted electromagnetic interference (EMI). At light load, the converter operates in discontinuous conduction mode (DCM) with valley switching and adaptive off-time control (AOT) to limit the switching frequency range and maintain load regulation. At extremely light load or in standby mode,burst mode operation is adopted to provide low power consumption through reducing both switching frequency and static power dissipation of the controller. The multi-mode control is implemented by an oscillator whose pulse duration is adjusted by output feedback. An accurate valley switching control circuit guarantees the minimum turn-on voltage drop of power switch. The pro-totype of the controller IC was fabricated in a 1.5um BiCMOS process and applied to a 310 V/20 V, 90 W flyback DC/DC converter circuitry. Experimental results showed that all expected functions were realized successfully. The flyback converter achieved a high efficiency of over 80% from full load down to 2.5 W, with the maximum reaching 88.8%, while the total power consumption in standby mode was about 300 mW.

  15. Consolidated bioprocessing (CBP) of AFEX™-pretreated corn stover for ethanol production using Clostridium phytofermentans at a high solids loading.

    Science.gov (United States)

    Jin, Mingjie; Gunawan, Christa; Balan, Venkatesh; Dale, Bruce E

    2012-08-01

    Consolidated bioprocessing (CBP) using Clostridium phytofermentans (ATCC 700394) on ammonia fiber expansion (AFEX™)-treated corn stover (AFEX™-CS) at a low solids loading showed promising results [Jin et al. (2011) Biotechnol Bioeng 108(6): 1290-1297]. However, industrial relevant process requires high solids loading. Therefore, we studied high solids loading CBP performance on AFEX™-CS. The factors potentially affecting the performance including solids loading, CBP products acetate and ethanol, and degradation products resulting from pretreatment were investigated. At 4% (w/w) glucan loading, C. phytofermentans performed well on AFEX™-CS with no nutrients supplementation and reached similar sugar conversions as a fermentation with nutrients supplementation. A glucan conversion of 48.9% and a xylan conversion of 77.9% were achieved after 264 h with 7.0 g/L ethanol and 8.8 g/L acetate produced. Relatively high concentrations of acetate produced at high solids loading was found to be the major factor limiting the CBP performance. Degradation products in AFEX™-CS helped enhance ethanol production.

  16. Effect of Temperature on the Void Growth in Pure Aluminium at High Strain-Rate Loading

    Institute of Scientific and Technical Information of China (English)

    QI Mei-Lan; HE Hong-Liang; YAN Shi-Lin

    2007-01-01

    @@ With the environment temperature varying from 273K to 773K, the dynamic process of void growth in pure aluminium at high strain-rate loading is calculated based on the dynamic growth equation of a void with internal pressure. The result shows that the effect of temperature on the growth of void should be emphasized. Because the initial pressure of void with gas will increase and the viscosity of materials will decrease with the rising of temperature, the growth of void is accelerated. Furthermore, material inertia restrains the growth of void evidently when the diameter exceeds 10μm. The effect of surface tension is very weak in the whole process of void growth.

  17. Enhancing pesticide degradation using indigenous microorganisms isolated under high pesticide load in bioremediation systems with vermicomposts.

    Science.gov (United States)

    Castillo Diaz, Jean Manuel; Delgado-Moreno, Laura; Núñez, Rafael; Nogales, Rogelio; Romero, Esperanza

    2016-08-01

    In biobed bioremediation systems (BBSs) with vermicomposts exposed to a high load of pesticides, 6 bacteria and 4 fungus strains were isolated, identified, and investigated to enhance the removal of pesticides. Three different mixtures of BBSs composed of vermicomposts made from greenhouse (GM), olive-mill (OM) and winery (WM) wastes were contaminated, inoculated, and incubated for one month (GMI, OMI and WMI). The inoculums maintenance was evaluated by DGGE and Q-PCR. Pesticides were monitored by HPLC-DAD. The highest bacterial and fungal abundance was observed in WMI and OMI respectively. In WMI, the consortia improved the removal of tebuconazole, metalaxyl, and oxyfluorfen by 1.6-, 3.8-, and 7.7-fold, respectively. The dissipation of oxyfluorfen was also accelerated in OMI, with less than 30% remaining after 30d. One metabolite for metalaxyl and 4 for oxyfluorfen were identified by GC-MS. The isolates could be suitable to improve the efficiency of bioremediation systems.

  18. Highly sensitive optical biosensor based on silicon-microring-resonator-loaded Mach–Zehnder interferometer

    Science.gov (United States)

    Yoshida, Soichiro; Ishihara, Shintaro; Arakawa, Taro; Kokubun, Yasuo

    2017-04-01

    We propose and demonstrate a novel biosensor based on a silicon-single-microring-resonator-loaded Mach–Zehnder interferometer (MRR-MZI), and discuss the design of the sensor theoretically. Owing to the combination of an MZI and the enhanced phase change in a microring resonator (MRR), high sensitivity is expected to be realized. The designed MRR-MZI sensor is fabricated using a CMOS-compatible process, and its sensing characteristics are measured using ethanol solutions with a concentration of less than 3 wt % and avidin solutions. The sensitivity of the MRR-MZI to changes in the environmental refractive index is increased by approximately 50 times compared with that of a simple MRR. In addition, avidin solution with a concentration as low as 20 pM was successfully detected.

  19. Toroidal cell and battery. [storage battery for high amp-hour load applications

    Science.gov (United States)

    Nagle, W. J. (Inventor)

    1981-01-01

    A toroidal storage battery designed to handle relatively high amp-hour loads is described. The cell includes a wound core disposed within a pair of toroidal channel shaped electrodes spaced apart by nylon insulator. The shape of the case electrodes of this toroidal cell allows a first planar doughnut shaped surface and the inner cylindrical case wall to be used as a first electrode and a second planar doughnut shaped surface and the outer cylindrical case wall to be used as a second electrode. Connectors may be used to stack two or more toroidal cells together by connecting substantially the entire surface area of the first electrode of a first cell to substantially the entire surface area of the second electrode of a second cell. The central cavity of each toroidal cell may be used as a conduit for pumping a fluid through the toroidal cell to thereby cool the cell.

  20. Vibration measurement through high speed vision system in a civil structure under impact loading

    Science.gov (United States)

    Ferrer, Belén; García, Juan I.; Roig, Ana B.; Mas, David

    2014-05-01

    The method presented in this work is a simple, cheap and non-contact method. It is based on image processing using a circular target. It has subpixel accuracy and it only needs a low cost high-speed camera and a tripod. In the work presented in this paper, a Casio Exilim camera was used to measure the vibration of a pedestrian bridge. An impact load was applied on the bridge through one person jumping in the middle of the bridge. Tracking of the circle border give the center trajectory and therefore the displacement and frequency of the movement. Some accelerometers were used as a contrast device for the frequency. The displacement obtained by our procedure was previously checked in laboratory using a micrometric bench. The results show that this method is suitable for measuring successfully the vibration of civil structures.

  1. Experimental investigation of fibre reinforced plastics with hybrid layups under high-velocity impact loads

    Directory of Open Access Journals (Sweden)

    Marco Romano

    2014-07-01

    Full Text Available This paper deals with experimental investigations concerning energy dissipation capacity of different kinds of reinforcement fibres in monolithic and hybrid layups under high-velocity impact loads. The investigated kinds of fibres are carbon, glass and basalt fibres. Therefore test panels, using the same thermoset resin, were built up and cured by autoclave processing. The fibre volume content of the test panels has been determined. Furthermore the influence of a separating layer at selected positions in the hybrid stacked panels was investigated. The results show the influence and the energy dissipation capacity of each single kind of fibre and the enhanced properties for the hybrid layups by hybrid stacking sequences and the use of a separating core material.

  2. High-Tip-Speed, Low-Loading Transonic Fan Stage. Part 1: Aerodynamic and Mechanical Design

    Science.gov (United States)

    Wright, L. C.; Vitale, N. G.; Ware, T. C.; Erwin, J. R.

    1973-01-01

    A high-tip-speed, low-loading transonic fan stage was designed to deliver an overall pressure ratio of 1.5 with an adiabatic efficiency of 86 percent. The design flow per unit annulus area is 42.0 pounds per square foot. The fan features a hub/tip ratio of 0.46, a tip diameter of 28.74 in. and operates at a design tip speed of 1600 fps. For these design conditions, the rotor blade tip region operates with supersonic inlet and supersonic discharge relative velocities. A sophisticated quasi-three-dimensional characteristic section design procedure was used for the all-supersonic sections and the inlet of the midspan transonic sections. For regions where the relative outlet velocities are supersonic, the blade operates with weak oblique shocks only.

  3. Training Load Monitoring Algorithms on Highly Sub-Metered Home Electricity Consumption Data

    Institute of Scientific and Technical Information of China (English)

    Mario Berges; Ethan Goldman; H. Scott Matthews; Lucio Soibelman

    2008-01-01

    The growing interest in energy-efficient buildings is driving changes in investment, design, and occupant behavior. To better focus cost and resource conservation efforts, electricity consumption feedback can be used to provide motivation, guidance, and verification. Disaggregating by end-use helps both con-sumers and producers to identify targets for conservation. While hardware-based sub-metering is costly and labor-intensive, non-intrusive load monitoring (NILM) is capable of gathering detailed energy-use data with minimal equipment cost and installation time. However, variations in measurements between metering de-vices complicate the process of compiling the necessary appliance profiles. Future work involves the devel-opment of NILM algorithms using sensor fusion and detailed appliance-level data gathered from a highly-sensed house currently being constructed near Pittsburgh, Pennsylvania.

  4. Removal of high organic loads from winery wastewater by aquatic plants.

    Science.gov (United States)

    Zimmels, Y; Kirzhner, F; Schreiber, J

    2008-09-01

    Laboratory- and field-scale purification tests of raw and diluted winery wastewater (WWW) were carried out using aquatic plants at high organic loads. The laboratory tests were performed using artificial light at 1800 to 1900 lux. The objective of the current study was to define the potential of floating and emergent aquatic macrophytes and the microorganisms attached to their roots, to reduce high organic loads that characterize WWW, thereby providing, for these effluents, an effective treatment and management system. These microorganisms are believed to have a major role in the treatment process. In this context, the potential of floating and emergent macrophytes to improve the water quality of raw compared with diluted WWW was evaluated. In raw WWW (chemical oxygen demand [COD] 5.6 g/L),growth inhibition of both water hyacinth (Eichhornia crassipes) and water pennywort (Hydrocotyle umbellata) was observed. A 1:1 dilution of WWW with fresh (tap) water facilitated growth of these plants. At this dilution level, growth of pennywort was limited, while that of water hyacinth was robust. In terms of reductions in biochemical oxygen demand, COD, and total suspended solids, both water hyacinth and pennywort performed better in diluted compared with raw WWW. At 1:1 and 1:3 dilution, 95.9 to 97% of the COD was removed after 23 days, in the presence of Hydrocotyle and Eichhornia plants and aeration. The capacity of new emergent plants to remove high organic loads from WWW, at enhanced kinetics, was demonstrated. This unique property was tested and compared with the role of the gravel media that support growth of the high-capacity emergent plants. In the presence of reed and salt marsh plants, 83 to 99% of the COD was removed within a period of 24 to 29 days, at 1.5:1 dilution. The new emergent plants proved to be effective, even at record high levels of COD. At an initial level of 16,460 mg/L, the COD was brought down to 2870 mg/L after 24 days (82.6% removal), while 12

  5. Protein growth factors loaded highly porous chitosan scaffold: A comparison of bone healing properties

    Energy Technology Data Exchange (ETDEWEB)

    Nandi, Samit K., E-mail: samitnandi1967@gmail.com [Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata (India); Kundu, Biswanath, E-mail: biswa_kundu@rediffmail.com [Bioceramics and Coating Division, CSIR—Central Glass and Ceramic Research Institute, Kolkata (India); Basu, Debabrata [Bioceramics and Coating Division, CSIR—Central Glass and Ceramic Research Institute, Kolkata (India)

    2013-04-01

    Present study aimed to investigate and compare effectiveness of porous chitosan alone and in combination with insulin like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) in bone healing. Highly porous (85 ± 2%) with wide distribution of macroporous (70–900 μm) chitosan scaffolds were fabricated as bone substitutes by employing a simple liquid hardening method using 2% (w/v) chitosan suspension. IGF-1 and BMP-2 were infiltrated using vacuum infiltration with freeze drying method. Adsorption efficiency was found to be 87 ± 2 and 90 ± 2% for BMP-2 and IGF-1 respectively. After thorough material characterization (pore details, FTIR and SEM), samples were used for subsequent in vivo animal trial. Eighteen rabbit models were used to evaluate and compare control (chitosan) (group A), chitosan with IGF-1 (group B) and chitosan with BMP-2 (group C) in the repair of critical size bone defect in tibia. Radiologically, there was evidence of radiodensity in defect area from 60th day (initiated on 30th day) in groups B and C as compared to group A and attaining nearly bony density in most of the part at day 90. Histological results depicted well developed osteoblastic proliferation around haversian canal along with proliferating fibroblast, vascularization and reticular network which was more pronounced in group B followed by groups C and A. Fluorochrome labeling and SEM studies in all groups showed similar outcome. Hence, porous chitosan alone and in combination with growth factors (GFs) can be successfully used for bone defect healing with slight advantage of IGF-1 in chitosan samples. - Highlights: ► Fabrication and characterization of porous chitosan with or without IGF-1 and BMP-2 ► Highly porous growth factor loaded chitosan studied in animal subjects for 3 months ► Parameters studied: histopathology, radiology and fluorochrome labeling ► IGF-1 loaded porous chitosan found to be very effective for bone defect healing.

  6. Multi-Mission Capable, High g Load mW RPS

    Energy Technology Data Exchange (ETDEWEB)

    John C. Bass; Nathan Hiller; Velimir Jovanovic; Norbert B. Elsner

    2007-05-23

    Over the past few years Hi-Z has been developing a wide range of mW generators and life testing thermoelectric modules for the Department of Energy (DOE) to fulfill requirements by NASA Ames and other agencies. The purpose of this report is to determine the capabilities of a wide range of mW generators for various missions. In the 1st quarterly report the power output of various mW generators was determined via thermal and mechanical modeling. The variable attributes of each generator modeled were: the number of RHUs (1-8), generator outer diameter (1.25-4 in.), and G-load (10, 500, or 2,000). The resultant power output was as high as 180 mW for the largest generator with the lowest Gload. Specifically, we looked at the design of a generator for high G loading that is insulated with Xenon gas and multifoil solid insulation. Because the design of this new generator varied considerably from the previous generator design, it was necessary to show in detail how it is to be assembled, calculate them as of the generator and determine the heat loss from the system. A new method of assembling the RHU was also included as part of the design. As a side issue we redesigned the test stations to provide better control of the cold sink temperature. This will help in reducing the test data by eliminating the need to 'normalize' the data to a specific temperature. In addition these new stations can be used to simulate the low ambient temperatures associated with Mars and other planets.

  7. Testosterone delays vascular smooth muscle cell senescence and inhibits collagen synthesis via the Gas6/Axl signaling pathway.

    Science.gov (United States)

    Chen, Yan-qing; Zhao, Jing; Jin, Cheng-wei; Li, Yi-hui; Tang, Meng-xiong; Wang, Zhi-hao; Zhang, Wei; Zhang, Yun; Li, Li; Zhong, Ming

    2016-06-01

    Testosterone deficiency is associated with a higher incidence of cardiovascular diseases in men. However, its effect on cell senescence, which plays a causal role in vascular aging, remains unclear. Here, we tested the hypothesis that testosterone alleviated vascular smooth muscle cell (VSMC) senescence and collagen synthesis via growth arrest-specific protein 6 (Gas6)/Axl- and Akt/FoxO1a-dependent pathways. Testosterone significantly ameliorated angiotensin II-induced VSMC senescence and collagen overexpression. In addition, testosterone inhibited angiotensin II-induced matrix metalloproteinase-2 (MMP-2) activity, which played a pivotal role in facilitating age-related collagen deposition. Testosterone increased the expression of tissue inhibitor of metalloproteinase-2 but decreased the expression of MMP-2 and membrane type-1 metalloproteinase which contributed to increase MMP-2 activity. The effects on VSMCs senescence and collagen synthesis were mediated by restoration of angiotensin II-induced downregulation of Gas6 and Axl expression and a subsequent reduction of Akt and FoxO1a phosphorylation. The effects of testosterone were reversed by a Gas6 blocker, Axl-Fc, and a specific inhibitor of Axl, R428. Treatment of VSMCs with PI3K inhibitor LY294002 abrogated the downregulating effect of testosterone on MMP-2 activity. Furthermore, when FoxO1a expression was silenced by using a specific siRNA, the inhibitory effect of testosterone on MMP-2 activity was revered as well, that indicated this process was Akt/FoxO1a dependence. Taken together, Gas6/Axl and Akt/FoxO1a were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis. Our results provide a novel mechanism underlying the protective effect of testosterone on vascular aging and may serve as a theoretical basis for testosterone replacement therapy.

  8. Evaluation of Dynamic Load Factors for a High-Speed Railway Truss Arch Bridge

    Directory of Open Access Journals (Sweden)

    Ding Youliang

    2016-01-01

    Full Text Available Studies on dynamic impact of high-speed trains on long-span bridges are important for the design and evaluation of high-speed railway bridges. The use of the dynamic load factor (DLF to account for the impact effect has been widely accepted in bridge engineering. Although the field monitoring studies are the most dependable way to study the actual DLF of the bridge, according to previous studies there are few field monitoring data on high-speed railway truss arch bridges. This paper presents an evaluation of DLF based on field monitoring and finite element simulation of Nanjing DaShengGuan Bridge, which is a high-speed railway truss arch bridge with the longest span throughout the world. The DLFs in different members of steel truss arch are measured using monitoring data and simulated using finite element model, respectively. The effects of lane position, number of train carriages, and speed of trains on DLF are further investigated. By using the accumulative probability function of the Generalized Extreme Value Distribution, the probability distribution model of DLF is proposed, based on which the standard value of DLF within 50-year return period is evaluated and compared with different bridge design codes.

  9. Optimization Design of Vehicle Front Axle Structure Based on ABAQUS and TOSCA%基于ABAQUS与TOSCA的汽车前桥结构优化设计

    Institute of Scientific and Technical Information of China (English)

    马瑞雪; 王欣; 覃祯员; 张科峰

    2012-01-01

    应用ABAQUS软件对汽车前桥进行强度分析,针对车桥强度不足问题,通过TOSCA优化软件对前桥进行拓扑优化设计,在保证承栽能力的前提下有效减轻其重量。%The author analyze the vehicle front axle for the strength by ABAQUS software. In view of the axle strength shortage problem, they use TOSCA optimization software designing the front axle topological optimization structure,in order to effectively reduce its weight under the condition of its bearing capacity.

  10. Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets

    Directory of Open Access Journals (Sweden)

    Cariou Bertrand

    2013-01-01

    Full Text Available Abstract Background PCSK9 (Proprotein Convertase Subtilisin Kexin type 9 is a circulating protein that promotes hypercholesterolemia by decreasing hepatic LDL receptor protein. Under non interventional conditions, its expression is driven by sterol response element binding protein 2 (SREBP2 and follows a diurnal rhythm synchronous with cholesterol synthesis. Plasma PCSK9 is associated to LDL-C and to a lesser extent plasma triglycerides and insulin resistance. We aimed to verify the effect on plasma PCSK9 concentrations of dietary interventions that affect these parameters. Methods We performed nutritional interventions in young healthy male volunteers and offspring of type 2 diabetic (OffT2D patients that are more prone to develop insulin resistance, including: i acute post-prandial hyperlipidemic challenge (n=10, ii 4 days of high-fat (HF or high-fat/high-protein (HFHP (n=10, iii 7 (HFruc1, n=16 or 6 (HFruc2, n=9 days of hypercaloric high-fructose diets. An acute oral fat load was also performed in two patients bearing the R104C-V114A loss-of-function (LOF PCSK9 mutation. Plasma PCSK9 concentrations were measured by ELISA. For the HFruc1 study, intrahepatocellular (IHCL and intramyocellular lipids were measured by 1H magnetic resonance spectroscopy. Hepatic and whole-body insulin sensitivity was assessed with a two-step hyperinsulinemic-euglycemic clamp (0.3 and 1.0 mU.kg-1.min-1. Findings HF and HFHP short-term diets, as well as an acute hyperlipidemic oral load, did not significantly change PCSK9 concentrations. In addition, post-prandial plasma triglyceride excursion was not altered in two carriers of PCSK9 LOF mutation compared with non carriers. In contrast, hypercaloric 7-day HFruc1 diet increased plasma PCSK9 concentrations by 28% (p=0.05 in healthy volunteers and by 34% (p=0.001 in OffT2D patients. In another independent study, 6-day HFruc2 diet increased plasma PCSK9 levels by 93% (p Conclusions Plasma PCSK9 concentrations vary

  11. DCM, FSM, dead time and width controllers for a high frequency high efficiency buck DC-DC converter over a wide load range

    Energy Technology Data Exchange (ETDEWEB)

    Pi Changming; Yan Wei; Zhang Ke; Li Wenhong, E-mail: wenhongli@fudan.edu.c [State Key Laboratory of ASIC and Systems, Fudan University, Shanghai 201203 (China)

    2010-08-15

    This paper presents a width controller, a dead time controller, a discontinuous current mode (DCM) controller and a frequency skipping modulation (FSM) controller for a high frequency high efficiency buck DC-DC converter. To improve the efficiency over a wide load range, especially at high switching frequency, the dead time controller and width controller are applied to enhance the high load efficiency, while the DCM controller and FSM controller are proposed to increase the light load efficiency. The proposed DC-DC converter controllers have been designed and fabricated in the Chartered 0.35 {mu}m CMOS process, and the measured results show that the efficiency of the buck DC-DC converter is above 80% over a wide load current range from 8 to 570 mA, and the peak efficiency is 86% at 10 MHz switching frequency. (semiconductor integrated circuits)

  12. Fermentative high-titer ethanol production from Douglas-fir forest residue without detoxification using SPORL: high SO2 loading at low temperature

    Science.gov (United States)

    Feng Gu; William Gilles; Roland Gleisner; J.Y. Zhu

    2016-01-01

    This study evaluated high sulfur dioxide (SO2) loading in applying Sulfite Pretreatment to Overcome the Recalcitrance of Lignocelluloses (SPORL) to Douglas-fir forest residue (FS-10) for ethanol production through yeast fermentation. Three pretreatments were conducted at 140

  13. SEMICONDUCTOR INTEGRATED CIRCUITS: DCM, FSM, dead time and width controllers for a high frequency high efficiency buck DC-DC converter over a wide load range

    Science.gov (United States)

    Changming, Pi; Wei, Yan; Ke, Zhang; Wenhong, Li

    2010-08-01

    This paper presents a width controller, a dead time controller, a discontinuous current mode (DCM) controller and a frequency skipping modulation (FSM) controller for a high frequency high efficiency buck DC-DC converter. To improve the efficiency over a wide load range, especially at high switching frequency, the dead time controller and width controller are applied to enhance the high load efficiency, while the DCM controller and FSM controller are proposed to increase the light load efficiency. The proposed DC-DC converter controllers have been designed and fabricated in the Chartered 0.35 μm CMOS process, and the measured results show that the efficiency of the buck DC-DC converter is above 80% over a wide load current range from 8 to 570 mA, and the peak efficiency is 86% at 10 MHz switching frequency.

  14. Hierarchical sulfur electrodes as a testing platform for understanding the high-loading capability of Li-S batteries

    Science.gov (United States)

    Chung, Sheng-Heng; Chang, Chi-Hao; Manthiram, Arumugam

    2016-12-01

    Lithium-sulfur (Li-S) batteries are considered as an attractive electrochemical energy storage system due to the high theoretical capacity of sulfur (1,675 mA h g-1). However, high-loading sulfur cathodes would need to be employed for the Li-S cells to be practical, but the resulting poor cell cyclability and severe electrode degradation hamper their development. Here, we present a hierarchical sulfur cathode as a testing platform for understanding the high-loading capability of Li-S batteries. The hierarchical cathode presents good electrochemical utilization of above 70%, stable cyclability for 500-1,000 cycles, and high sulfur loadings of 4.2-10.0 mg cm-2. The exploration of the activation and the polysulfide-retention processes of the high-loading cathodes illustrates that the electrochemical stability mainly results from the stabilization of dissolved polysulfides within the cathode region as the electrochemically active catholyte. Therefore, the utilization of stabilized polysulfide migration might be a meaningful opportunity for designing high-loading cathodes and further improving their electrochemical stability and long-term cyclability.

  15. Study on load forecasting to data centers of high power density based on power usage effectiveness

    Science.gov (United States)

    Zhou, C. C.; Zhang, F.; Yuan, Z.; Zhou, L. M.; Wang, F. M.; Li, W.; Yang, J. H.

    2016-08-01

    There is usually considerable energy consumption in data centers. Load forecasting to data centers is in favor of formulating regional load density indexes and of great benefit to getting regional spatial load forecasting more accurately. The building structure and the other influential factors, i.e. equipment, geographic and climatic conditions, are considered for the data centers, and a method to forecast the load of the data centers based on power usage effectiveness is proposed. The cooling capacity of a data center and the index of the power usage effectiveness are used to forecast the power load of the data center in the method. The cooling capacity is obtained by calculating the heat load of the data center. The index is estimated using the group decision-making method of mixed language information. An example is given to prove the applicability and accuracy of this method.

  16. Effect of cyclic high loading rates on the fatigue strength of aluminum-based composites

    Science.gov (United States)

    Calderon Arteaga, Hermes Eskander

    The study of fatigue under high loading rates is of great interest in the complete characterization of a new series of composites with Al-Cu-Mg matrix reinforced with AlB2 dispersoids. Homogeneous and functionally graded composites were prepared via gravity and centrifugal casting, respectively. Through centrifugal casting a gradual variation of the volume fraction of reinforcing particles along the cross section was obtained. In specific fabrication conditions, even complete segregation of the reinforcement particles was achieved. Charpy impact tests as well as hardness tests were conducted to assess the composite strength as a function of the weight percent of boron. The tensile properties of gravity cast samples were obtained. Then for both casting conditions, simple edge-notched bend SE(B) specimens were tested under fatigue conditions (three-point bending). The results from impact and hardness tests allowed identifying an interaction between the Mg dissolved in the matrix and the diborides. This interaction, which has never been reported before, was responsible for the strength reduction observed. It was assumed that a substitutional diffusion of Al by Mg atoms in the hp3 structure of diboride was causing the strength reduction, and three approaches were developed to estimate the amount of Mg depleted from the matrix by the diborides during the composite processing. Gravity cast samples were more sensitive to monotonic damage due to fatigue loads where compared with functionally-graded composites. Contrary to the centrifugal cast samples, gravity samples were also affected by the loading rate. The Mg-AlB2 interaction was also responsible for the reduction in the fatigue resistance as the weight percent of boron increased in both types of composites; regression models were obtained to predict the crack growth curve slope change as function of the boron level. The particle distribution showed to affect the crack growth behavior of the FGMs, decreasing the

  17. Effect of high pressure pasteurization on bacterial load and bioactivity of Echinacea purpurea.

    Science.gov (United States)

    Chen, Xiu-Min; Hu, Chun; Raghubeer, Errol; Kitts, David D

    2010-09-01

    High hydrostatic pressure (HHP) technology was applied to organic Echinacea purpurea (E. purpurea) roots and flowers to determine the feasibility of using this technology for cold herb pasteurization, to produce microbiologically safe and shelf-stable products for the natural health products (NHPs) industry. HHP significantly (P purpurea methanol-derived extracts, evaluated in both chemical (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) [ABTS] and oxygen radical absorption capacity [ORAC] assay) and in cell culture models (RAW264, 7 macrophage, H(2)O(2)-induced intracellular oxidation, and lipopolysaccharide [LPS]-induced nitric oxide production), was not adversely affected by the application of HHP at both 2 and 5 min at 600 mPa. Furthermore, HHP did not affect the capacity of E. purpurea extracts to suppress nitric oxide production in LPS-activated macrophage cells. Therefore, our results show that HHP is an effective pasteurization process treatment to reduce microbial-contamination load while not adversely altering chemical and bioactive function of active constituents present in organic E. purpurea. Our study reports for the first time, the effectiveness of using high hydrostatic pressure (HHP) technology pressure to pasteurize E. purpurea root and flower, and the comparative retention of bioactive phytochemicals. Therefore, this technique can be used in food and natural health product industries to produce high-quality, microbiologically safe, and shelf-stable products.

  18. Synthesis of High Valence Silver-Loaded Mesoporous Silica with Strong Antibacterial Properties

    Science.gov (United States)

    Chen, Chun-Chi; Wu, Hsin-Hsien; Huang, Hsin-Yi; Liu, Chen-Wei; Chen, Yi-Ning

    2016-01-01

    A simple chemical method was developed for preparing high valence silver (Ag)-loaded mesoporous silica (Ag-ethylenediaminetetraacetic acid (EDTA)-SBA-15), which showed strong antibacterial activity. Ag-EDTA-SBA-15 exhibited stronger and more effective antibacterial activity than commercial Ag nanoparticles did, and it offered high stability of high valence silver in the porous matrix and long-lasting antibacterial activity. The synthesized materials were characterized using Fourier transform infrared spectroscopy, powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) analysis, and transmission electron microscopy (TEM). Ag existed in both surface complexation and Ag particles. EDTA anchored within a porous structure chelated Ag ions in higher oxidation states and prevented their agglomeration and oxidation reduction. The XRD results showed that most Ag in the Ag-EDTA-SBA-15 existed in higher oxidation states such as Ag(II) and Ag(III). However, the XPS and TEM results showed that Ag easily reduced in lower oxidation states and agglomerated as Ag particles on the exterior layer of the SBA-15. PMID:26742050

  19. Synthesis of High Valence Silver-Loaded Mesoporous Silica with Strong Antibacterial Properties

    Directory of Open Access Journals (Sweden)

    Chun-Chi Chen

    2016-01-01

    Full Text Available A simple chemical method was developed for preparing high valence silver (Ag-loaded mesoporous silica (Ag-ethylenediaminetetraacetic acid (EDTA-SBA-15, which showed strong antibacterial activity. Ag-EDTA-SBA-15 exhibited stronger and more effective antibacterial activity than commercial Ag nanoparticles did, and it offered high stability of high valence silver in the porous matrix and long-lasting antibacterial activity. The synthesized materials were characterized using Fourier transform infrared spectroscopy, powder X-ray diffraction (XRD, X-ray photoelectron spectroscopy (XPS analysis, and transmission electron microscopy (TEM. Ag existed in both surface complexation and Ag particles. EDTA anchored within a porous structure chelated Ag ions in higher oxidation states and prevented their agglomeration and oxidation reduction. The XRD results showed that most Ag in the Ag-EDTA-SBA-15 existed in higher oxidation states such as Ag(II and Ag(III. However, the XPS and TEM results showed that Ag easily reduced in lower oxidation states and agglomerated as Ag particles on the exterior layer of the SBA-15.

  20. Synthesis of High Valence Silver-Loaded Mesoporous Silica with Strong Antibacterial Properties.

    Science.gov (United States)

    Chen, Chun-Chi; Wu, Hsin-Hsien; Huang, Hsin-Yi; Liu, Chen-Wei; Chen, Yi-Ning

    2016-01-04

    A simple chemical method was developed for preparing high valence silver (Ag)-loaded mesoporous silica (Ag-ethylenediaminetetraacetic acid (EDTA)-SBA-15), which showed strong antibacterial activity. Ag-EDTA-SBA-15 exhibited stronger and more effective antibacterial activity than commercial Ag nanoparticles did, and it offered high stability of high valence silver in the porous matrix and long-lasting antibacterial activity. The synthesized materials were characterized using Fourier transform infrared spectroscopy, powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) analysis, and transmission electron microscopy (TEM). Ag existed in both surface complexation and Ag particles. EDTA anchored within a porous structure chelated Ag ions in higher oxidation states and prevented their agglomeration and oxidation reduction. The XRD results showed that most Ag in the Ag-EDTA-SBA-15 existed in higher oxidation states such as Ag(II) and Ag(III). However, the XPS and TEM results showed that Ag easily reduced in lower oxidation states and agglomerated as Ag particles on the exterior layer of the SBA-15.

  1. Novel Acoustic Loading of a Mass Spectrometer: Toward Next-Generation High-Throughput MS Screening.

    Science.gov (United States)

    Sinclair, Ian; Stearns, Rick; Pringle, Steven; Wingfield, Jonathan; Datwani, Sammy; Hall, Eric; Ghislain, Luke; Majlof, Lars; Bachman, Martin

    2016-02-01

    High-throughput, direct measurement of substrate-to-product conversion by label-free detection, without the need for engineered substrates or secondary assays, could be considered the "holy grail" of drug discovery screening. Mass spectrometry (MS) has the potential to be part of this ultimate screening solution, but is constrained by the limitations of existing MS sample introduction modes that cannot meet the throughput requirements of high-throughput screening (HTS). Here we report data from a prototype system (Echo-MS) that uses acoustic droplet ejection (ADE) to transfer femtoliter-scale droplets in a rapid, precise, and accurate fashion directly into the MS. The acoustic source can load samples into the MS from a microtiter plate at a rate of up to three samples per second. The resulting MS signal displays a very sharp attack profile and ions are detected within 50 ms of activation of the acoustic transducer. Additionally, we show that the system is capable of generating multiply charged ion species from simple peptides and large proteins. The combination of high speed and low sample volume has significant potential within not only drug discovery, but also other areas of the industry.

  2. Creep-fatigue of High Temperature Materials for VHTR: Effect of Cyclic Loading and Environment

    Energy Technology Data Exchange (ETDEWEB)

    Celine Cabet; L. Carroll; R. Wright; R. Madland

    2011-05-01

    Alloy 617 is the one of the leading candidate materials for Intermediate Heat eXchangers (IHX) of a Very High Temperature Reactor (VHTR). System start-ups and shut-downs as well as power transients will produce low cycle fatigue (LCF) loadings of components. Furthermore, the anticipated IHX operating temperature, up to 950°C, is in the range of creep so that creep-fatigue interaction, which can significantly increase the fatigue crack growth, may be one of the primary IHX damage modes. To address the needs for Alloy 617 codification and licensing, a significant creep-fatigue testing program is underway at Idaho National Laboratory. Strain controlled LCF tests including hold times up to 1800s at maximum tensile strain were conducted at total strain range of 0.3% and 0.6% in air at 950°C. Creep-fatigue testing was also performed in a simulated VHTR impure helium coolant for selected experimental conditions. The creep-fatigue tests resulted in failure times up to 1000 hrs. Fatigue resistance was significantly decreased when a hold time was added at peak stress and when the total strain was increased. The fracture mode also changed from transgranular to intergranular with introduction of a tensile hold. Changes in the microstructure were methodically characterized. A combined effect of temperature, cyclic and static loading and environment was evidenced in the targeted operating conditions of the IHX. This paper This paper reviews the data previously published by Carroll and co-workers in references 10 and 11 focusing on the role of inelastic strain accumulation and of oxidation in the initiation and propagation of surface fatigue cracks.

  3. Metasurface Reflector (MSR Loading for High Performance Small Microstrip Antenna Design.

    Directory of Open Access Journals (Sweden)

    Md Rezwanul Ahsan

    Full Text Available A meander stripline feed multiband microstrip antenna loaded with metasurface reflector (MSR structure has been designed, analyzed and constructed that offers the wireless communication services for UHF/microwave RFID and WLAN/WiMAX applications. The proposed MSR assimilated antenna comprises planar straight forward design of circular shaped radiator with horizontal slots on it and 2D metasurface formed by the periodic square metallic element that resembles the behavior of metamaterials. A custom made high dielectric bio-plastic substrate (εr = 15 is used for fabricating the prototype of the MSR embedded planar monopole antenna. The details of the design progress through numerical simulations and experimental results are presented and discussed accordingly. The measured impedance bandwidth, radiation patterns and gain of the proposed MSR integrated antenna are compared with the obtained results from numerical simulation, and a good compliance can be observed between them. The investigation shows that utilization of MSR structure has significantly broadened the -10 dB impedance bandwidth than the conventional patch antenna: from 540 to 632 MHz (17%, 467 to 606 MHz (29% and 758 MHz to 1062 MHz (40% for three distinct operating bands centered at 0.9, 3.5 and 5.5 GHz. Additionally, due to the assimilation of MSR, the overall realized gains have been upgraded to a higher value of 3.62 dBi, 6.09 dBi and 8.6 dBi for lower, middle and upper frequency band respectively. The measured radiation patterns, impedance bandwidths (S11<-10 dB and gains from the MSR loaded antenna prototype exhibit reasonable characteristics that can satisfy the requirements of UHF/microwave (5.8 GHz RFID, WiMAX (3.5/5.5 GHz and WLAN (5.2/5.8 GHz applications.

  4. Metasurface Reflector (MSR) Loading for High Performance Small Microstrip Antenna Design

    Science.gov (United States)

    Ahsan, Md Rezwanul; Islam, Mohammad Tariqul; Ullah, Mohammad Habib; Singh, Mandeep Jit; Ali, Mohd Tarmizi

    2015-01-01

    A meander stripline feed multiband microstrip antenna loaded with metasurface reflector (MSR) structure has been designed, analyzed and constructed that offers the wireless communication services for UHF/microwave RFID and WLAN/WiMAX applications. The proposed MSR assimilated antenna comprises planar straight forward design of circular shaped radiator with horizontal slots on it and 2D metasurface formed by the periodic square metallic element that resembles the behavior of metamaterials. A custom made high dielectric bio-plastic substrate (εr = 15) is used for fabricating the prototype of the MSR embedded planar monopole antenna. The details of the design progress through numerical simulations and experimental results are presented and discussed accordingly. The measured impedance bandwidth, radiation patterns and gain of the proposed MSR integrated antenna are compared with the obtained results from numerical simulation, and a good compliance can be observed between them. The investigation shows that utilization of MSR structure has significantly broadened the -10dB impedance bandwidth than the conventional patch antenna: from 540 to 632 MHz (17%), 467 to 606 MHz (29%) and 758 MHz to 1062 MHz (40%) for three distinct operating bands centered at 0.9, 3.5 and 5.5 GHz. Additionally, due to the assimilation of MSR, the overall realized gains have been upgraded to a higher value of 3.62 dBi, 6.09 dBi and 8.6 dBi for lower, middle and upper frequency band respectively. The measured radiation patterns, impedance bandwidths (S11<-10 dB) and gains from the MSR loaded antenna prototype exhibit reasonable characteristics that can satisfy the requirements of UHF/microwave (5.8 GHz) RFID, WiMAX (3.5/5.5 GHz) and WLAN (5.2/5.8 GHz) applications. PMID:26018795

  5. Low platinum loading for high temperature proton exchange membrane fuel cell developed by ultrasonic spray coating technique

    Science.gov (United States)

    Su, Huaneng; Jao, Ting-Chu; Barron, Olivia; Pollet, Bruno G.; Pasupathi, Sivakumar

    2014-12-01

    This paper reports use of an ultrasonic-spray for producing low Pt loadings membrane electrode assemblies (MEAs) with the catalyst coated substrate (CCS) fabrication technique. The main MEA sub-components (catalyst, membrane and gas diffusion layer (GDL)) are supplied from commercial manufacturers. In this study, high temperature (HT) MEAs with phosphoric acid (PA)-doped poly(2,5-benzimidazole) (AB-PBI) membrane are fabricated and tested under 160 °C, hydrogen and air feed 100 and 250 cc min-1 and ambient pressure conditions. Four different Pt loadings (from 0.138 to 1.208 mg cm-2) are investigated in this study. The experiment data are determined by in-situ electrochemical methods such as polarization curve, electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The high Pt loading MEA exhibits higher performance at high voltage operating conditions but lower performances at peak power due to the poor mass transfer. The Pt loading 0.350 mg cm-2 GDE performs the peak power density and peak cathode mass power to 0.339 W cm-2 and 0.967 W mgPt-1, respectively. This work presents impressive cathode mass power and high fuel cell performance for high temperature proton exchange membrane fuel cells (HT-PEMFCs) with low Pt loadings.

  6. Difference in kinematics and kinetics between high- and low-velocity resistance loading equated by volume: implications for hypertrophy training.

    Science.gov (United States)

    Mohamad, Nur Ikhwan; Cronin, John B; Nosaka, Ken K

    2012-01-01

    Although it is generally accepted that a high load is necessary for muscle hypertrophy, it is possible that a low load with a high velocity results in greater kinematics and kinetics than does a high load with a slow velocity. The purpose of this study was to determine if 2 training loads (35 and 70% 1 repetition maximum [1RM]) equated by volume, differed in terms of their session kinematic and kinetic characteristics. Twelve subjects were recruited in this acute randomized within-subject crossover design study. Two bouts of a half-squat exercise were performed 1 week apart, one with high load-low velocity (HLLV = 3 sets of 12 reps at 70% 1RM) and the other with low-load high-velocity (LLHV = 6 sets of 12 reps at 35% 1RM). Time under tension (TUT), average force, peak force (PF), average power (AP), peak power (PP), work (TW), and total impulse (TI) were calculated and compared between loads for the eccentric and concentric phases. For average eccentric and concentric single repetition values, significantly (p eccentric and concentric TUT, PF, AP, PP, and TW. The only variable that was significantly greater for the HLLV protocol than for the LLHV protocol was TI (∼20-24%). From these results, it seems that the LLHV protocol may offer an equal if not better training stimulus for muscular adaptation than the HLLV protocol, because of the greater time under tension, power, force, and work output when the total volume of the exercise is equated.

  7. Viral DNA load of high-risk human papilloma virus is closely associated with the grade of cervical lesions

    OpenAIRE

    Shen, Guqun; Cheng, Jingxin; Wang, Yan; Zhou, Ping; Zhang, Guoqing

    2014-01-01

    This study is to explore the correlation between the viral load of high-risk human papilloma virus (HPV) and the degree of cervical lesions, as well as the follow-up monitoring role of high-risk HPV measurements in the treatment of patients with cervical lesions. Hybrid capture-2 method was used to measure the amount of high-risk HPV load of 361 patients who were enrolled from January 2009 to December 2010 at the Affiliated Tumor Hospital of Xinjiang Medical University, including 76 cases of ...

  8. Design of Model Following Variable Structure Controller for Three-axle Vehicle

    Institute of Scientific and Technical Information of China (English)

    管西强; 张建武; 屈求真

    2003-01-01

    An optimal control procedure is developed for the front and rear wheels of a three-axle vehicle moving on a complex typical road based on model following variable structure control strategy. The actual vehicle may be considered as an uncertain system. Cornering stiffness of front and rear wheels and external disturbances are varied in a limited range. The model-following variable structure control method is used to control both front and rear wheels steering operations of the vehicle, so that steering responses of the vehicle follow from those of the reference model. By numerical results obtained from computer simulation, it is demonstrated that the control system model can cope with the effects of parameter perturbations and outside disturbances.

  9. PROBABILISTIC MODELS FOR LONG FATIGUE CRACK GROWTH RATES OF LZ50 AXLE STEEL

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yong-xiang; HE Chao-ming; YANG Bing; HUANG Yu-zhong; GAO Qing; WU Ping-bo

    2005-01-01

    Experimental study is performed on the probabilistic models for the long fatigue crack growth rates (da/dN) of LZ50 axle steel. An equation for crack growth rate was derived to consider the trend of stress intensity factor range going down to the threshold and the average stress effect. The probabilistic models were presented on the equation. They consist of the probabilistic da/dN-△K relations, the confidence-based da/dN-△K relations, and the probabilistic- and confidence-based da/dN-△K relations.Efforts were made respectively to characterize the effects of probabilistic assessments due to the scattering regularity of test data, the number of sampling, and both of them.These relations can provide wide selections for practice. Analysis on the test data of LZ50 steel indicates that the present models are available and feasible.

  10. A NARX damper model for virtual tuning of automotive suspension systems with high-frequency loading

    Science.gov (United States)

    Alghafir, M. N.; Dunne, J. F.

    2012-02-01

    A computationally efficient NARX-type neural network model is developed to characterise highly nonlinear frequency-dependent thermally sensitive hydraulic dampers for use in the virtual tuning of passive suspension systems with high-frequency loading. Three input variables are chosen to account for high-frequency kinematics and temperature variations arising from continuous vehicle operation over non-smooth surfaces such as stone-covered streets, rough or off-road conditions. Two additional input variables are chosen to represent tuneable valve parameters. To assist in the development of the NARX model, a highly accurate but computationally excessive physical damper model [originally proposed by S. Duym and K. Reybrouck, Physical characterization of non-linear shock absorber dynamics, Eur. J. Mech. Eng. M 43(4) (1998), pp. 181-188] is extended to allow for high-frequency input kinematics. Experimental verification of this extended version uses measured damper data obtained from an industrial damper test machine under near-isothermal conditions for fixed valve settings, with input kinematics corresponding to harmonic and random road profiles. The extended model is then used only for simulating data for training and testing the NARX model with specified temperature profiles and different valve parameters, both in isolation and within quarter-car vehicle simulations. A heat generation and dissipation model is also developed and experimentally verified for use within the simulations. Virtual tuning using the quarter-car simulation model then exploits the NARX damper to achieve a compromise between ride and handling under transient thermal conditions with harmonic and random road profiles. For quarter-car simulations, the paper shows that a single tuneable NARX damper makes virtual tuning computationally very attractive.

  11. Effects of Radiation and a High Iron Load on Bone Mineral Density

    Science.gov (United States)

    Yuen, E.; Morgan, J. L. L.; Zwart, S. R.; Gonzales, E.; Camp, K.; Smith, S. M.; Bloomfield, S. A.

    2012-01-01

    Astronauts on long duration space flight missions to the moon or mars are exposed to radiation and have increase iron (Fe) stores, both of which can independently induce oxidative stress and may exacerbate bone mass loss and strength. We hypothesize a high Fe diet and a fractionated gamma radiation exposure would increase oxidative stress and lower bone mass. Three mo-old, SD rats (n=32) were randomized to receive an adequate Fe diet (45 mg Fe/kg diet) or a high Fe diet (650 mg Fe/kg diet) for 4 wks and either a cumulative 3 Gy dose (fractionated 8 x 0.375 Gy) of gamma radiation (Cs-137) or sham exposure starting on day 14. Elisa kit assessed serum catalase, clinical analyzer assessed serum Fe status and ex vivo pQCT scans measured bone parameters in the proximal/midshaft tibia and femoral neck. Mechanical strength was assessed by 3-pt bending and femoral neck test. There is a significant decrease in trabecular bone mineral density (BMD) from radiation (p less than 0.05) and a trend in diet (p=0.05) at the proximal tibia. There is a significant interaction in cortical BMD from the combined treatments at the midshaft tibia (p less than 0.05). There is a trending decrease in total BMD from diet (p=0.07) at the femoral neck. In addition, high serum Fe was correlated to low trabecular BMD (p less than 0.05) and high serum catalase was correlated to low BMD at all 3 bone sites (p less than 0.05). There was no difference in the max load of the tibia or femoral neck. Radiation and a high iron diet increases iron status and catalase in the serum and decreases BMD.

  12. Phase change based cooling for high burst mode heat loads with temperature regulation above the phase change temperature

    Science.gov (United States)

    The United States of America as represented by the United States Department of Energy

    2009-12-15

    An apparatus and method for transferring thermal energy from a heat load is disclosed. In particular, use of a phase change material and specific flow designs enables cooling with temperature regulation well above the fusion temperature of the phase change material for medium and high heat loads from devices operated intermittently (in burst mode). Exemplary heat loads include burst mode lasers and laser diodes, flight avionics, and high power space instruments. Thermal energy is transferred from the heat load to liquid phase change material from a phase change material reservoir. The liquid phase change material is split into two flows. Thermal energy is transferred from the first flow via a phase change material heat sink. The second flow bypasses the phase change material heat sink and joins with liquid phase change material exiting from the phase change material heat sink. The combined liquid phase change material is returned to the liquid phase change material reservoir. The ratio of bypass flow to flow into the phase change material heat sink can be varied to adjust the temperature of the liquid phase change material returned to the liquid phase change material reservoir. Varying the flowrate and temperature of the liquid phase change material presented to the heat load determines the magnitude of thermal energy transferred from the heat load.

  13. Effects of acute creatine loading with or without carbohydrate on repeated bouts of maximal swimming in high-performance swimmers.

    Science.gov (United States)

    Theodorou, Apostolos S; Havenetidis, Konstantinos; Zanker, Cathy L; O'Hara, John P; King, Roderick F G J; Hood, Colin; Paradisis, Giorgios; Cooke, Carlton B

    2005-05-01

    The addition of carbohydrate (CHO) to an acute creatine (Cr) loading regimen has been shown to increase muscle total creatine content significantly beyond that achieved through creatine loading alone. However, the potential ergogenic effects of combined Cr and CHO loading have not been assessed. The purpose of this study was to compare swimming performance, assessed as mean swimming velocity over repeated maximal intervals, in high-performance swimmers before and after an acute loading regimen of either creatine alone (Cr) or combined creatine and carbohydrate (Cr + CHO). Ten swimmers (mean +/- SD of age and body mass: 17.8 +/- 1.8 years and 72.3 +/- 6.8 kg, respectively) of international caliber were recruited and were randomized to 1 of 2 groups. Each swimmer ingested five 5 g doses of creatine for 4 days, with the Cr + CHO group also ingesting approximately 100 g of simple CHO 30 minutes after each dose of creatine. Performance was measured on 5 separate occasions: twice at "baseline" (prior to intervention, to assess the repeatability of the performance test), within 48 hours after intervention, and then 2 and 4 weeks later. All subjects swam faster after either dietary loading regimen (p swimmers continued to produce faster swim times for up to 4 weeks after intervention. Our findings suggest that no performance advantage was gained from the addition of carbohydrate to a creatine-loading regimen in these high-caliber swimmers.

  14. Low level perceptual, not attentional, processes modulate distractor interference in high perceptual Load displays: evidence from neglect/extinction

    Directory of Open Access Journals (Sweden)

    Carmel eMevorach

    2014-01-01

    Full Text Available According to perceptual load theory (Lavie, 2005 distractor interference is determined by the availability of attentional resources. If target processing does not exhaust resources (with low perceptual load distractor processing will take place resulting in interference with a primary task; however when target processing uses-up attentional capacity (with high perceptual load interference can be avoided. An alternative account (Tsal & Benoni, 2010 suggests that perceptual load effects can be based on distractor dilution by the mere presence of additional neutral items in high load displays so that the effect is not driven by the amount of attention resources required for target processing. Here we tested whether patients with unilateral neglect or extinction would show dilution effects from neutral items in their contralesional (neglected/extinguished field, even though these items do not impose increased perceptual load on the target and at the same time attract reduced attentional resources compared to stimuli in the ipsilesional field. Thus, such items do not affect the amount of attention resources available for distractor processing. We found that contralesional neutral elements can eliminate distractor interference as strongly as centrally presented ones in neglect/extinction patients, despite contralesional items being less well attended. The data are consistent with an account in terms of perceptual dilution of distracters rather than available resources for distractor processing. We conclude that distractor dilution can underlie the elimination of distractor interference in visual displays.

  15. Low level perceptual, not attentional, processes modulate distractor interference in high perceptual load displays: evidence from neglect/extinction.

    Science.gov (United States)

    Mevorach, Carmel; Tsal, Yehoshua; Humphreys, Glyn W

    2014-01-10

    According to perceptual load theory (Lavie, 2005) distractor interference is determined by the availability of attentional resources. If target processing does not exhaust resources (with low perceptual load) distractor processing will take place resulting in interference with a primary task; however, when target processing uses-up attentional capacity (with high perceptual load) interference can be avoided. An alternative account (Tsal and Benoni, 2010a) suggests that perceptual load effects can be based on distractor dilution by the mere presence of additional neutral items in high-load displays so that the effect is not driven by the amount of attention resources required for target processing. Here we tested whether patients with unilateral neglect or extinction would show dilution effects from neutral items in their contralesional (neglected/extinguished) field, even though these items do not impose increased perceptual load on the target and at the same time attract reduced attentional resources compared to stimuli in the ipsilesional field. Thus, such items do not affect the amount of attention resources available for distractor processing. We found that contralesional neutral elements can eliminate distractor interference as strongly as centrally presented ones in neglect/extinction patients, despite contralesional items being less well attended. The data are consistent with an account in terms of perceptual dilution of distracters rather than available resources for distractor processing. We conclude that distractor dilution can underlie the elimination of distractor interference in visual displays.

  16. The characterization of secondary lithium-ion battery degradation when operating complex, ultra-high power pulsed loads

    Science.gov (United States)

    Wong, Derek N.

    The US Navy is actively developing all electric fleets, raising serious questions about what is required of onboard power supplies in order to properly power the ship's electrical systems. This is especially relevant when choosing a viable power source to drive high power propulsion and electric weapon systems in addition to the conventional loads deployed aboard these types of vessels. Especially when high pulsed power loads are supplied, the issue of maintaining power quality becomes important and increasingly complex. Conventionally, a vessel's electrical power is generated using gas turbine or diesel driven motor-generator sets that are very inefficient when they are used outside of their most efficient load condition. What this means is that if the generator is not being utilized continuously at its most efficient load capacity, the quality of the output power may also be effected and fall outside of the acceptable power quality limits imposed through military standards. As a solution to this potential problem, the Navy has proposed using electrochemical storage devices since they are able to buffer conventional generators when the load is operating below the generator's most efficient power level or able to efficiently augment a generator when the load is operating in excess of the generator's most efficient power rating. Specifically, the US Navy is interested in using commercial off-the-shelf (COTS) lithium-ion batteries within an intelligently controlled energy storage module that could act as either a prime power supply for on-board pulsed power systems or as a backup generator to other shipboard power systems. Due to the unique load profile of high-rate pulsed power systems, the implementation of lithium-ion batteries within these complex systems requires them to be operated at very high rates and the effects these things have on cell degradation has been an area of focus. There is very little published research into the effects that high power transient

  17. Absorbing coatings for high power millimeter-wave devices and matched loads

    Energy Technology Data Exchange (ETDEWEB)

    Bin, W., E-mail: wbin@ifp.cnr.it [Istituto di Fisica del Plasma, Consiglio Nazionale delle Ricerche, EURATOM-ENEA/CNR Association, Milano (Italy); Bruschi, A.; Cirant, S. [Istituto di Fisica del Plasma, Consiglio Nazionale delle Ricerche, EURATOM-ENEA/CNR Association, Milano (Italy); Muzzini, V. [Istituto di Biologia Agro-ambientale e Forestale, Consiglio Nazionale delle Ricerche, Area di Ricerca di Roma 1, Monterotondo, Rome (Italy); Simonetto, A.; Spinicchia, N. [Istituto di Fisica del Plasma, Consiglio Nazionale delle Ricerche, EURATOM-ENEA/CNR Association, Milano (Italy); Angella, G. [Istituto per l’Energetica e le Interfasi, Consiglio Nazionale delle Ricerche, Milano (Italy); Dell’Era, F. [Istituto di Fisica del Plasma, Consiglio Nazionale delle Ricerche, EURATOM-ENEA/CNR Association, Milano (Italy); Gantenbein, G.; Leonhardt, W. [Institut für Hochleistungsimpuls-und Mikrowellentechnik, Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Nardone, A. [Istituto di Fisica del Plasma, Consiglio Nazionale delle Ricerche, EURATOM-ENEA/CNR Association, Milano (Italy); Samartsev, A.; Schmid, M. [Institut für Hochleistungsimpuls-und Mikrowellentechnik, Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany)

    2013-10-15

    Highlights: ► An overview of the activity at IFP-CNR concerning the absorbing coatings is presented. ► The application of the absorbing ceramics to the IFP-CNR matched loads is described. ► B{sub 4}C is presented as a promising material for power absorption in the EC frequency range. ► The most important high power validation tests performed on coatings are described. ► Some results from simulations of the absorption capability of a double layer coating are shown. -- Abstract: In the electron cyclotron frequency range the handling of high power is critical. In some cases an unpredictable amount of stray radiation can reach some components or accumulate in localized regions, with risk of damages caused by thermal overloads, and any uncontrolled reflection represents a danger for the sources. A possibility to mitigate the problem consists in covering some regions exposed to radiation with absorbers. Enhanced absorption of stray radiation lowers requirements on active protection systems in microwave diagnostics. The released heat can be extracted by dedicated cooling systems. The chromium oxide (Cr{sub 2}O{sub 3}), largely tested at IFP-CNR, has been routinely used as internal coating for matched loads. The performances of a variable thickness coating has been tested at high power at Karlsruhe Institute of Technology (KIT), with a 140 GHz gyrotron of the W7-X ECRH system and an averaged power density absorbed at the coating surface higher than 1 MW/m{sup 2} for 3 min. Also boron carbide (B{sub 4}C) has been tested at low power and patented as a millimeter-wave absorber. In the paper, the results of some tests performed on these coatings are given, together with some simulations of the absorption capability based on low power measurements on samples. Finally, some calculations are presented for a coating obtained combining together Cr{sub 2}O{sub 3} and B{sub 4}C.

  18. Development of a new time domain-based algorithm for train detection and axle counting

    Science.gov (United States)

    Allotta, B.; D'Adamio, P.; Meli, E.; Pugi, L.

    2015-12-01

    This paper presents an innovative train detection algorithm, able to perform the train localisation and, at the same time, to estimate its speed, the crossing times on a fixed point of the track and the axle number. The proposed solution uses the same approach to evaluate all these quantities, starting from the knowledge of generic track inputs directly measured on the track (for example, the vertical forces on the sleepers, the rail deformation and the rail stress). More particularly, all the inputs are processed through cross-correlation operations to extract the required information in terms of speed, crossing time instants and axle counter. This approach has the advantage to be simple and less invasive than the standard ones (it requires less equipment) and represents a more reliable and robust solution against numerical noise because it exploits the whole shape of the input signal and not only the peak values. A suitable and accurate multibody model of railway vehicle and flexible track has also been developed by the authors to test the algorithm when experimental data are not available and in general, under any operating conditions (fundamental to verify the algorithm accuracy and robustness). The railway vehicle chosen as benchmark is the Manchester Wagon, modelled in the Adams VI-Rail environment. The physical model of the flexible track has been implemented in the Matlab and Comsol Multiphysics environments. A simulation campaign has been performed to verify the performance and the robustness of the proposed algorithm, and the results are quite promising. The research has been carried out in cooperation with Ansaldo STS and ECM Spa.

  19. Bed load size distribution and flow conditions in a high mountain catchment of Central Pyrenees

    Directory of Open Access Journals (Sweden)

    Martínez-Castroviejo, Ricardo

    1990-06-01

    Full Text Available The bed load size distribution caused by different types of flow are compared in a high mountain catchment located in the upper Gallego river basin (Central Spanish’ Pyrenees. Three kinds of hydrologic events could be defined: those triggered by heavy autumn rainfalls, those originated by isolated summer rainstorms and those promoted by snowmelting. Each one is characterized by a peculiar bed load size distribution. Thus, it could be demonstrated that the coarser fractions, above 30 mm in diameter, are up to six times more abundant, in percentage of total weight, in transports caused by heavy rainfalls than in the material collected after snowmelt flows. In its turn, bed load mobilized by snowmelt flows is mainly composed by medium and fine gravel, from 2 to 8 mm. These may amount up to 60 % of total weight of bed load. The reasons for these so different size distributions are discussed.

    [es] En una cuenca de alta montaña localizada en el alto valle del río Gallego (Pirineo central se comparan las distribuciones por tamaños de los acarreos movilizados por diferentes tipos de caudal. Tres tipos de eventos hidrológicos han podido ser caracterizados: los ocasionados por intensas lluvias de otoño, los originados por tormentas estivales aisladas y los producidos por la fusión de la nieve acumulada durante el invierno. Se concluye que cada uno de ellos lleva asociada una distribución por tamaños típica de la carga de fondo. Así, se ha comprobado que las fracciones más gruesas consideradas -superiores a los 30 mm de diámetro- son hasta seis veces más abundantes -en porcentaje sobre el peso total- en las exportaciones causadas por lluvias de gran intensidad que en las generadas por caudales de fusión. A su vez, las descargas ocasionadas por la fusión arrastran principalmente gravas de calibre medio y fino -entre 2y8 mm- que llegan a suponer el 60 % en peso del volumen movilizado. Este artículo discute las razones que provocan

  20. Francis-99: Transient CFD simulation of load changes and turbine shutdown in a model sized high-head Francis turbine

    Science.gov (United States)

    Mössinger, Peter; Jester-Zürker, Roland; Jung, Alexander

    2017-01-01

    With increasing requirements for hydropower plant operation due to intermittent renewable energy sources like wind and solar, numerical simulations of transient operations in hydraulic turbo machines become more important. As a continuation of the work performed for the first workshop which covered three steady operating conditions, in the present paper load changes and a shutdown procedure are investigated. The findings of previous studies are used to create a 360° model and compare measurements with simulation results for the operating points part load, high load and best efficiency. A mesh motion procedure is introduced, allowing to represent moving guide vanes for load changes from best efficiency to part load and high load. Additionally an automated re-mesh procedure is added for turbine shutdown to ensure reliable mesh quality during guide vane closing. All three transient operations are compared to PIV velocity measurements in the draft tube and pressure signals in the vaneless space. Simulation results of axial velocity distributions for all three steady operation points, during both load changes and for the shutdown correlated well with the measurement. An offset at vaneless space pressure is found to be a result of guide vane corrections for the simulation to ensure similar velocity fields. Short-time Fourier transformation indicating increasing amplitudes and frequencies at speed-no load conditions. Further studies will discuss the already measured start-up procedure and investigate the necessity to consider the hydraulic system dynamics upstream of the turbine by means of a 1D3D coupling between the 3D flow field and a 1D system model.

  1. Demonstration of sulfur solubility determinations in high waste loading, low-activity waste glasses

    Energy Technology Data Exchange (ETDEWEB)

    Fox, K. M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-04-25

    A method recommended by Pacific Northwest National Laboratory (PNNL) for sulfate solubility determinations in simulated low-activity waste glasses was demonstrated using three compositions from a recent Hanford high waste loading glass study. Sodium and sulfate concentrations in the glasses increased after each re-melting step. Visual observations of the glasses during the re-melting process reflected the changes in composition. The measured compositions showed that the glasses met the targeted values. The amount of SO3 retained in the glasses after washing was relatively high, ranging from 1.6 to 2.6 weight percent (wt %). Measured SnO2 concentrations were notably low in all of the study glasses. The composition of the wash solutions should be measured in future work to determine whether SnO2 is present with the excess sulfate washed from the glass. Increases in batch size and the amount of sodium sulfate added did not have a measureable impact on the amount of sulfate retained in the glass, although this was tested for only a single glass composition. A batch size of 250 g and a sodium sulfate addition targeting 7 wt %, as recommended by PNNL, will be used in future experiments.

  2. Application of CCG Sensors to a High-Temperature Structure Subjected to Thermo-Mechanical Load

    Directory of Open Access Journals (Sweden)

    Weihua Xie

    2016-10-01

    Full Text Available This paper presents a simple methodology to perform a high temperature coupled thermo-mechanical test using ultra-high temperature ceramic material specimens (UHTCs, which are equipped with chemical composition gratings sensors (CCGs. The methodology also considers the presence of coupled loading within the response provided by the CCG sensors. The theoretical strain of the UHTCs specimens calculated with this technique shows a maximum relative error of 2.15% between the analytical and experimental data. To further verify the validity of the results from the tests, a Finite Element (FE model has been developed to simulate the temperature, stress and strain fields within the UHTC structure equipped with the CCG. The results show that the compressive stress exceeds the material strength at the bonding area, and this originates a failure by fracture of the supporting structure in the hot environment. The results related to the strain fields show that the relative error with the experimental data decrease with an increase of temperature. The relative error is less than 15% when the temperature is higher than 200 °C, and only 6.71% at 695 °C.

  3. Microstructural and Chemical Characterization of the Tribolayer Formation in Highly Loaded Cylindrical Roller Thrust Bearings

    Directory of Open Access Journals (Sweden)

    Carsten Gachot

    2016-06-01

    Full Text Available Zinc dithiophosphates (ZDDP have been widely applied in automobile industry for over 70 years as a lubricant additive for wear protection. Tribolayers have been described as blue- and brown-colored layers on surfaces observed by microscopical observation or even bare eye presumably as a consequence of layer thickness or chemical composition. However, the reaction pathways of ZDDP tribolayers are still not yet fully understood. In the present study, the difference between the blue- and brown-colored tribolayers has been revealed by high resolution methods in cylindrical roller thrust bearings at relatively high contact pressures of around 1.92 GPa. After running a FE8 standard bearing test with a normal load of 80 kN and a temperature of 60 °C, said tribolayers could be identified on the bearing surfaces. By using Raman spectroscopy, it could be shown that the blue-colored layers are enriched by FeS and ZnS whereas the brown-colored layers show a significant amount of Fe3O4. This is an interesting finding as it clearly shows a correlation between the color appearance of the films and the chemical composition besides potential film thickness variations. Finally, transmission electron microscopy verified the amorphous nature of the formed tribolayer which is in a good agreement with literature.

  4. Characterization of ITER tungsten qualification mock-ups exposed to high cyclic thermal loads

    Energy Technology Data Exchange (ETDEWEB)

    Pintsuk, Gerald, E-mail: g.pintsuk@fz-juelich.de [Forschungszentrum Jülich GmbH, D-52425 Jülich (Germany); Bednarek, Maja; Gavila, Pierre [Fusion for Energy, E-08019 Barcelona (Spain); Gerzoskovitz, Stefan [Plansee SE, Innovation Services, 6600 Reutte (Austria); Linke, Jochen [Forschungszentrum Jülich GmbH, D-52425 Jülich (Germany); Lorenzetto, Patrick; Riccardi, Bruno [Fusion for Energy, E-08019 Barcelona (Spain); Escourbiac, Frederic [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 Saint Paul lez Durance (France)

    2015-10-15

    Highlights: • Mechanical deformation of CuCrZr in case a thermal barrier layer has been formed due to impurity content in the cooling water. • Crack formation at the W/Cu interface starting at the block edge. • Porosity formation in the pure Cu interlayer. • Microstructural changes in tungsten down to the W/Cu interface, which indicates also high temperatures for the pure Cu interlayer. • Macrocrack formation in tungsten which is assumed to be ductile at the initiation point and brittle when proceeding toward the cooling tube. - Abstract: High heat flux tested small-scale tungsten monoblock mock-ups (5000 cycles at 10 MW/m{sup 2} and up to 1000 cycles at 20 MW/m{sup 2}) manufactured by Plansee and Ansaldo were characterized by metallographic means. Therein, the macrocrack formation and propagation in tungsten, its recrystallization behavior and the surface response to different heat load facilities were investigated. Furthermore, debonding at the W/Cu interface, void formation in the soft copper interlayer and microcrack formation at the inner surface of the CuCrZr cooling tube were found.

  5. MORPHOLOGY AND PROPERTIES OF LINEAR LOW-DENSITY POLYETHYLENE HIGHLY LOADED WITH ALUMINUM HYDROXIDE

    Institute of Scientific and Technical Information of China (English)

    Gen-lin Wang; Ping-kai Jiang; Zi-kang Zhu; Jie Yin

    2002-01-01

    An experimental study was carried out to investigate the effects of isopropoxy tri(dioctyl pyrophosphoryl) titanate coupling agent on the mechanical performance, rheological property and microstructures of polyethylene highly loaded with aluminum hydroxide (Al(OH)a) composite. It was found that the addition of coupling agent results in reduced tensile strength and increased percentage elongation of the filled systems. Silane crosslinkable polyethylene substituting for polyethylene as matrix improves the tensile strength of the composite, while the percentage elongation of the composite still remains at a desired level. Melt viscosity of the composite will be improved by addition of titanate coupling agent. Microstructures of the composites were also studied by means of the scanning electron microscopy (SEM) technique. SEM micrographs reveal that finer dispersion of Al(OH)3 will be obtained upon treatment of titanate and a transition from brittle to tough fracture takes place before and after silane crosslinking structure is introduced into polyethylene highly filled with Al(OH)3 composite.

  6. The effect of high intensity ultrasound on the loading of Au nanoparticles into titanium dioxide.

    Science.gov (United States)

    Belova, Valentina; Borodina, Tatiana; Möhwald, Helmuth; Shchukin, Dmitry G

    2011-01-01

    Novel metal/semiconductor nanocomposites have been synthesized from pre-formed components by applying high intensity ultrasound irradiation. Positively and negatively charged Au nanoparticles were intercalated into mesoporous TiO(2) by sonication. The synthesized nanocomposites with implanted gold nanoparticles possess a narrow pore-size distribution around 7 nm and a large surface area of about 210 m(2)/g. The intercalation of the Au nanoparticles into the TiO(2) framework depends on the charge of the Au nanoparticles, time and amplitude of ultrasonic treatment. The experiments show that at 20 min of ultrasonic irradiation the volume fraction of the negatively charged Au nanoparticles intercalated into TiO(2) is 15%. By contrast, at the same time, 8.1% of positively charged Au nanoparticles with a diameter of about 6-7 nm enters into the TiO(2) matrix. The characterization of the samples was carried out by X-ray diffraction, transmission electron microscopy, high-resolution transmission electron microscopy, scanning electron microscopy, Fourier transform infrared measurements and BET analysis. The structure of TiO(2) was not considerably affected by the intercalation of the Au nanoparticles. TiO(2) doped with negatively charged Au nanoparticles presented a higher photocatalytic activity (75 wt.%) than TiO(2) loaded with positively charged Au nanoparticles (62 wt.%), because of an enlarged surface area and quantity of Au nanoparticles in titania. Copyright © 2010 Elsevier B.V. All rights reserved.

  7. High-speed motion picture camera experiments of cavitation in dynamically loaded journal bearings

    Science.gov (United States)

    Hamrock, B. J.; Jacobson, B. O.

    1983-01-01

    A high-speed camera was used to investigate cavitation in dynamically loaded journal bearings. The length-diameter ratio of the bearing, the speeds of the shaft and bearing, the surface material of the shaft, and the static and dynamic eccentricity of the bearing were varied. The results reveal not only the appearance of gas cavitation, but also the development of previously unsuspected vapor cavitation. It was found that gas cavitation increases with time until, after many hundreds of pressure cycles, there is a constant amount of gas kept in the cavitation zone of the bearing. The gas can have pressures of many times the atmospheric pressure. Vapor cavitation bubbles, on the other hand, collapse at pressures lower than the atmospheric pressure and cannot be transported through a high-pressure zone, nor does the amount of vapor cavitation in a bearing increase with time. Analysis is given to support the experimental findings for both gas and vapor cavitation. Previously announced in STAR as N82-20543

  8. Application of CCG Sensors to a High-Temperature Structure Subjected to Thermo-Mechanical Load

    Science.gov (United States)

    Xie, Weihua; Meng, Songhe; Jin, Hua; Du, Chong; Wang, Libin; Peng, Tao; Scarpa, Fabrizio; Xu, Chenghai

    2016-01-01

    This paper presents a simple methodology to perform a high temperature coupled thermo-mechanical test using ultra-high temperature ceramic material specimens (UHTCs), which are equipped with chemical composition gratings sensors (CCGs). The methodology also considers the presence of coupled loading within the response provided by the CCG sensors. The theoretical strain of the UHTCs specimens calculated with this technique shows a maximum relative error of 2.15% between the analytical and experimental data. To further verify the validity of the results from the tests, a Finite Element (FE) model has been developed to simulate the temperature, stress and strain fields within the UHTC structure equipped with the CCG. The results show that the compressive stress exceeds the material strength at the bonding area, and this originates a failure by fracture of the supporting structure in the hot environment. The results related to the strain fields show that the relative error with the experimental data decrease with an increase of temperature. The relative error is less than 15% when the temperature is higher than 200 °C, and only 6.71% at 695 °C. PMID:27754356

  9. The Combined Effect of Electrical Stimulation and High-Load Isometric Contraction on Protein Degradation Pathways in Muscle Atrophy Induced by Hindlimb Unloading

    OpenAIRE

    Naoto Fujita; Shinichiro Murakami; Hidemi Fujino

    2011-01-01

    High-load isometric exercise is considered an effective countermeasure against muscle atrophy, but therapeutic electrical stimulation for muscle atrophy is often performed without loading. In the present study, we investigated the combined effectiveness of electrical stimulation and high-load isometric contraction in preventing muscle atrophy induced by hindlimb unloading. Electrical stimulation without loading resulted in slight attenuation of muscle atrophy. Moreover, combining electrical s...

  10. Research on Heating Problem of Rotary Kiln Axle Tile Care%回转窑托轮轴瓦发热问题的研究

    Institute of Scientific and Technical Information of China (English)

    和春梅; 杨晓杰; 罗玉银

    2011-01-01

    The rotary kiln, as the "heart" equipment of cement production, often appears the phenomenon of tile prop shaft heat in the using process,which lead to the low efficiency of rotary kiln.This article analyzes the main causes of heating problem of the rotary kiln tile axle from the two aspects of the lubrication and load distribution condition, and proposes the appropriate preventive measures.%回转窑作为水泥生产时的"心脏"设备,在使用过程中常常出现托轮轴瓦发热的现象,这是导致回转窑工作效率降低的最直接和最普遍的问题.本文主要从润滑状态和载荷分布情况与两个方面,分析了回转窑托轮轴瓦发热的主要原因,并指出了相应的预防措施.

  11. High voltage dc-dc converter with dynamic voltage regulation and decoupling during load-generated arcs

    Science.gov (United States)

    Shimer, Daniel W.; Lange, Arnold C.

    1995-01-01

    A high-power power supply produces a controllable, constant high voltage output under varying and arcing loads. The power supply includes a voltage regulator, an inductor, an inverter for producing a high frequency square wave current of alternating polarity, an improved inverter voltage clamping circuit, a step up transformer, an output rectifier for producing a dc voltage at the output of each module, and a current sensor for sensing output current. The power supply also provides dynamic response to varying loads by controlling the voltage regulator duty cycle and circuitry is provided for sensing incipient arc currents at the output of the power supply to simultaneously decouple the power supply circuitry from the arcing load. The power supply includes a plurality of discrete switching type dc--dc converter modules.

  12. Tribological Evaluation of Candidate Gear Materials Operating Under Light Loads in Highly Humid Conditions

    Science.gov (United States)

    Dellacorte, Christopher; Thomas, Fransua; Leak, Olivia Ann

    2015-01-01

    A series of pin-on-disk sliding wear tests were undertaken to identify candidate materials for a pair of lightly loaded timing gears operating under highly humid conditions. The target application involves water purification and thus precludes the use of oil, grease and potentially toxic solid lubricants. The baseline sliding pair is austenitic stainless steel operating against a carbon filled polyimide. The test load and sliding speed (4.9 N, 2.7 m/s) were chosen to represent average contact conditions of the meshing gear teeth. In addition to the baseline materials, the hard superelastic NiTiNOL 60 (60NiTi) was slid against itself, against the baseline polyimide, and against 60NiTi onto which a commercially deposited dry film lubricant (DFL) was applied. The alternate materials were evaluated as potential replacements to achieve a longer wear life and improved dimensional stability for the timing gear application. An attempt was also made to provide solid lubrication to self-mated 60NiTi by rubbing the polyimide against the disk wear track outside the primary 60NiTi-60NiTi contact, a method named stick or transfer-film lubrication. The selected test conditions gave repeatable friction and wear data and smooth sliding surfaces for the baseline materials similar to those in the target application. Friction and wear for self-mated stainless steel were high and erratic. Self-mated 60NiTi gave acceptably low friction (approx. 0.2) and modest wear but the sliding surfaces were rough and potentially unsuitable for the gear application. Tests in which 60NiTi pins were slid against DFL coated 60NiTi and DFL coated stainless steel gave low friction and long wear life. The use of stick lubrication via the secondary polyimide pin provided effective transfer film lubrication to self-mated 60NiTi tribological specimens. Using this approach, friction levels were equal or lower than the baseline polyimide-stainless combination and wear was higher but within data scatter observed

  13. Lowering the platinum loading of high temperature polymer electrolyte membrane fuel cells with acid doped polybenzimidazole membranes

    DEFF Research Database (Denmark)

    Fernandez, Santiago Martin; Li, Qingfeng; Jensen, Jens Oluf

    2015-01-01

    Membrane electrode assemblies (MEAs) with ultra-low Pt loading electrodes were prepared for high temperature polymer electrolyte membrane fuel cells (HT-PEMFCs) based on acid doped polybenzimidazole. With no electrode binders or ionomers, the triple phase boundary of the catalyst layer was establ......Membrane electrode assemblies (MEAs) with ultra-low Pt loading electrodes were prepared for high temperature polymer electrolyte membrane fuel cells (HT-PEMFCs) based on acid doped polybenzimidazole. With no electrode binders or ionomers, the triple phase boundary of the catalyst layer...

  14. Dry coating of micronized API powders for improved dissolution of directly compacted tablets with high drug loading.

    Science.gov (United States)

    Han, Xi; Ghoroi, Chinmay; Davé, Rajesh

    2013-02-14

    Motivated by our recent study showing improved flow and dissolution rate of the active pharmaceutical ingredient (API) powders (20 μm) produced via simultaneous micronization and surface modification through continuous fluid energy milling (FEM) process, the performance of blends and direct compacted tablets with high drug loading is examined. Performance of 50 μm API powders dry coated without micronization is also considered for comparison. Blends of micronized, non-micronized, dry coated or uncoated API powders at 30, 60 and 70% drug loading, are examined. The results show that the blends containing dry coated API powders, even micronized ones, have excellent flowability and high bulk density compared to the blends containing uncoated API, which are required for direct compaction. As the drug loading increases, the difference between dry coated and uncoated blends is more pronounced, as seen in the proposed bulk density-FFC phase map. Dry coating led to improved tablet compactibility profiles, corresponding with the improvements in blend compressibility. The most significant advantage is in tablet dissolution where for all drug loadings, the t(80) for the tablets with dry coated APIs was well under 5 min, indicating that this approach can produce nearly instant release direct compacted tablets at high drug loadings.

  15. Ethanol Production from High Solids Loading of Alkali-Pretreated Sugarcane Bagasse with an SSF Process

    Directory of Open Access Journals (Sweden)

    Yueshu Gao

    2014-04-01

    Full Text Available A fed-batch process and high-temperature simultaneous saccharification and fermentation (SSF process were investigated to obtain high sugar yield and ethanol concentration. Different amounts of alkali-pretreated sugarcane bagasse were added during the first 24 h. For the highest final dry matter (DM content of 25% (w/v, a maximal glucose and total sugar concentration of 79.53 g/L and 135.39 g/L, respectively, were achieved with 8.3 FPU/g substrate after 120 h of hydrolysis. Based on the hydrolysis experiment, two processes for ethanol production from sugarcane bagasse, simultaneous saccharification and fermentation (SSF and separate hydrolysis and fermentation (SHF, were also compared using S. cerevisiae. The results indicated that ethanol concentration and yield in the SHF were higher, while ethanol productivity (gram per unit volume and over time was lower. For 25% substrate loading, the ethanol productivity and ethanol concentration could reach 0.38 g.L-1.h-1 and 36.25 g/L SSF in 96 h, respectively, while that of SHF could reach 0.32 g.L-1.h-1, with an ethanol concentration of 47.95 g/L in 152 h for SHF. When high-temperature simultaneous saccharification and fermentation (SSF process was performed by using Kluyveromyces marxianus NCYC 587 at 42 °C, 42.21 g/L ethanol (with an ethanol productivity of 0.44 g.L-1.h-1 was produced with 25% dry matter content and 8.3 FPU cellulase/g substrate, which meant 16.4% more ethanol when compared with SSF of S. cerevisiae.

  16. RELATIONSHIP BETWEEN BLOOD LACTATE AND HYPERVENTILATION DURING HIGH-INTENSITY CONSTANT-LOAD EXERCISE IN HEAT

    Directory of Open Access Journals (Sweden)

    T. Chiba

    2011-09-01

    Full Text Available The purpose of this study was to examine the relationship between hyperventilation and increase in blood lactate during high-intensity constant-load exercise in heat and normal conditions. Seven male volunteers exercised for 10 min on a cycle ergometer at 80%·VO2max in heat (40ºC, 50%relative humidity: HT and normal conditions (20ºC, 50% relative humidity: CON. Oxygen uptake, carbon dioxide output, ventilation, blood lactate and blood electrolytes (K , Na , Cl− were measured in HT and CON. We found that ventilation was significantly higher during exercise in HT compared with CON (p<0.05 and RER tends to be higher in HT than in CON. Blood lactate was significantly higher at 3 min during exercise in HT compared with CON (5.96 ± 0.57 mEq·l-1 5.00 ± 0.28 mEq·l-1, p<0.05. Change in strong ion difference [∆SID = (∆K ∆Na − (∆Cl− ∆La−], which affects ∆HCO3− in blood significantly, was lower at 5 min during exercise in HT compared with in CON (p<0.05. These results suggest that hyperventilation during exercise in heat would induce lower HCO3− in blood and consequently would result in an increase in blood lactate at an earlier time during high-intensity exercise in heat. It was concluded that hyperventilation during short-term high-intensity exercise in heat is temporarily associated with an increase in blood lactate.

  17. Lateral Load-Resisting System Using Mass Timber Panel for High-Rise Buildings

    Directory of Open Access Journals (Sweden)

    Zhiyong Chen

    2017-07-01

    Full Text Available As global interest in using engineered wood products in tall buildings intensifies due to the “green” credential of wood, it is expected that more tall wood buildings will be designed and constructed in the coming years. This, however, brings new challenges to the designers. One of the major challenges is how to design lateral load-resisting systems (LLRSs with sufficient stiffness, strength, and ductility to resist strong wind and earthquakes. In this study, an LLRS using mass timber panel on a stiff podium was developed for high-rise buildings in accordance with capacity-based design principle. The LLRS comprises eight shear walls with a core in the center of the building, which was constructed with structural composite lumber and connected with dowel-type connections and wood–steel composite system. The main energy dissipating mechanism of the LLRS was detailed to be located at the panel-to-panel interface. This LLRS was implemented in the design of a hypothetical 20-storey building. A finite element (FE model of the building was developed using general-purpose FE software, ABAQUS. The wind-induced and seismic response of the building model was investigated by performing linear static and non-linear dynamic analyses. The analysis results showed that the proposed LLRS using mass timber was suitable for high-rise buildings. This study provided a valuable insight into the structural performance of LLRS constructed with mass timber panels as a viable option to steel and concrete for high-rise buildings.

  18. Evaluation of drug loading capabilities of γ-cyclodextrin-metal organic frameworks by high performance liquid chromatography.

    Science.gov (United States)

    Xu, Xiaonan; Wang, Caifen; Li, Haiyan; Li, Xue; Liu, Botao; Singh, Vikramjeet; Wang, Shuxia; Sun, Lixin; Gref, Ruxandra; Zhang, Jiwen

    2017-03-10

    Drug loading into γ-cyclodextrin-metal organic frameworks (γ-CD-MOFs) using the impregnation approach is a laborious process. In this study, a γ-CD-MOF construct (2-5μm particle diameter) was used as the stationary phase under HPLC conditions with the aim to correlate retention properties and drug loading capability of the CD-based structure. Ketoprofen, fenbufen and diazepam were chosen as model drugs with m-xylene as a control analyte to investigate the correlation of drug loading and their chromatographic behaviour in the γ-CD-MOF column. Furthermore, γ-CD itself was also prepared as the stationary phase by coupling with silica in the column to illustrate the enhanced interaction between drugs and γ-CD-MOF as a reference. The retention and loading efficiency of the drugs were determined with different ratios of hexane and ethanol (10:90, 20:80, 50:50, 80:20, 90:10, v/v) at temperatures of 20, 25, 30 and 37°C. With the increment in hexane content, the loading efficiency of ketoprofen and fenbufen increased from 2.39±0.06% to 4.38±0.04% and from 5.82±0.94% to 6.37±0.29%, respectively. The retention time and loading efficiency of ketoprofen and diazepam were the lowest at 30°C while those of fenbufen had the different tendency. The excellent relation between the retention and loading efficiency onto γ-CD-MOF could be clearly observed through mobile phase and temperature investigation. In conclusion, a highly efficient chromatographic method has been established to evaluate the drug loading capability of γ-CD-MOF.

  19. Scan-directed load balancing for highly-parallel mesh-connected computers. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    Biagioni, E.S.; Prins, J.F.

    1991-07-01

    Scan Directed Load Balancing is a new, locality-preserving, dynamic load balancing algorithm for grid based computations on mesh connected parallel computers. Scans are used to efficiently determine what areas of the machine are heavily loaded and what areas are lightly loaded, and to organize the movement of data. Data is shifted along the mesh in a regular fashion to balance the load. The Locality Property of the algorithm guarantees that all the neighbors of a data point on the grid are stored either on the same processor, or on a processor that is directly connected to it. Scan Directed Load Balancing is applicable to both SIMD and MIMD mesh-connected parallel computers, and has been implemented on the MasPar MP-1. The authors present some theoretical bounds achieved by the algorithm as well as the algorithm's performance on a particular image processing problem, edge-directed diffusion. Their experiments show that the algorithm is effective in improving the load distribution for real problems, while the efficiency of the original grid-based computation is preserved by the locality property.

  20. Optimization of {beta}-carotene loaded solid lipid nanoparticles preparation using a high shear homogenization technique

    Energy Technology Data Exchange (ETDEWEB)

    Triplett, Michael D., E-mail: triplettm@battelle.or [Battelle Memorial Institute, Health and Life Sciences Global Business (United States); Rathman, James F. [The Ohio State University, Department of Chemical and Biomolecular Engineering (United States)

    2009-04-15

    Using statistical experimental design methodologies, the solid lipid nanoparticle design space was found to be more robust than previously shown in literature. Formulation and high shear homogenization process effects on solid lipid nanoparticle size distribution, stability, drug loading, and drug release have been investigated. Experimentation indicated stearic acid as the optimal lipid, sodium taurocholate as the optimal cosurfactant, an optimum lecithin to sodium taurocholate ratio of 3:1, and an inverse relationship between mixing time and speed and nanoparticle size and polydispersity. Having defined the base solid lipid nanoparticle system, {beta}-carotene was incorporated into stearic acid nanoparticles to investigate the effects of introducing a drug into the base solid lipid nanoparticle system. The presence of {beta}-carotene produced a significant effect on the optimal formulation and process conditions, but the design space was found to be robust enough to accommodate the drug. {beta}-Carotene entrapment efficiency averaged 40%. {beta}-Carotene was retained in the nanoparticles for 1 month. As demonstrated herein, solid lipid nanoparticle technology can be sufficiently robust from a design standpoint to become commercially viable.

  1. Flaw assessment guide for high-temperature reactor components subject to creep-fatigue loading

    Energy Technology Data Exchange (ETDEWEB)

    Ainsworth, R.A. (Nuclear Electric PLC, Berkeley (UK). Berkeley Nuclear Labs.); Ruggles, M.B. (Oak Ridge National Lab., TN (USA)); Takahashi, Y. (Central Research Inst. of Electric Power Industry, Komae, Tokyo (Japan). Komae Research Lab.)

    1990-10-01

    A high-temperature flaw assessment procedure is described. This procedure is a result of a collaborative effort between Electric Power Research Institute in the United States, Central Research Institute of Electric Power Industry in Japan, and Nuclear Electric plc in the United Kingdom. The procedure addresses preexisting defects subject to creep-fatigue loading conditions. Laws employed to calculate the crack growth per cycle are defined in terms of fracture mechanics parameters and constants related to the component material. The crack-growth laws can be integrated to calculate the remaining life of a component or to predict the amount of crack extension in a given period. Fatigue and creep crack growth per cycle are calculated separately, and the total crack extension is taken as the simple sum of the two contributions. An interaction between the two propagation modes is accounted for in the material properties in the separate calculations. In producing the procedure, limitations of the approach have been identified. 25 refs., 1 fig.

  2. Bearing Capacity of High Density Polyethylene (HDPE Reinforced Sand Using Plate Load Test

    Directory of Open Access Journals (Sweden)

    Er. Aly K

    2015-06-01

    Full Text Available The work presented here is a study to examine the improvement in bearing capacity of coastal sand of Trivandrum, Kerala, India using high density polyethylene (HDPE /woven fabric as reinforcement in discrete layers. The bearing capacity was evaluated using plate load test. The effect of reinforcement configurations like sheet reinforcement (sanded with adhesive, with adhesive and sheet alone and strip reinforcement (single and grid pattern are investigated. The test parameters chosen for the present study are, depth of topmost layer of reinforcement layer below footing, compacted density and number of layers of reinforcement etc. From the tests, it has been observed that sheet reinforcement is more effective than sheet sanded with adhesive and strip reinforcements. It is found that the synthetic adhesive gives no binding action at the interface of the reinforcement and soil. But it is to be noted that the sheet with adhesive dried has a marked influence on the bearing capacity especially at lower densities. The strip reinforcements in single pattern is considered to be a favorable choice for minimum reinforcement. The strip reinforcement in single or grid pattern gives sufficient improvement in strength.

  3. Investigation of vacuum properties of CuCrZr alloy for high-heat-load absorber

    Science.gov (United States)

    Shueh, C.; Chan, C. K.; Chang, C. C.; Sheng, I. C.

    2017-01-01

    The Taiwan Photon Source (TPS) uses high-heat-load (HHL) absorbers to protect downstream ultrahigh-vacuum chambers from overheating. In this work, we propose to use the CuCrZr alloy (ASTM C18150) for the HHL absorber body and the ConFlat flanges. We use the throughput method to measure the thermal outgassing rate and a helium leak detector to verify the vacuum seal between the CuCrZr alloy and stainless-steel flanges. The measured outgassing rate of the CuCrZr alloy was 5.8×10-10 Pa m/s after 72 h of pumping and decreased to 2.0 × 10-10 Pa m/s after 100 h of pumping. The leak rate through the vacuum seal between a CuCrZr flange and a stainless-steel flange was less than 1 × 10-10 Pa m3/s even after mounting and unmounting the flanges ten times and baking them at 250 °C. These results indicate that CuCrZr alloy is suitable for integrating HHL components with ConFlat CuCrZr flanges for the absorption of the synchrotron radiation generated by the TPS.

  4. Biomass accumulation modelling in a highly loaded biotrickling filter for hydrogen sulphide removal.

    Science.gov (United States)

    Mannucci, Alberto; Munz, Giulio; Mori, Gualtiero; Lubello, Claudio

    2012-07-01

    A pilot scale test on a biotrickling filter packed with polyurethane foam cubes was carried out for 110 d at high volumetric mass load (up to 280 g m(bed)(-3) h(-1)) with the aim of studying the accumulation of solids in the treatment of H(2)S. Removal rate up to 245 g m(bed)(-3) h(-1) was obtained; however, an accumulation of gypsum, elemental sulphur and, above all, inert biomass was identified as the cause of an increased pressure drop over the long term. A mathematical model was applied and calibrated with the experimental results to describe the accumulation of biomass. The model was capable of describing the accumulation of solids and, corresponding to a solids retention time of 50 d, the observed yield resulted in 0.07 g of solids produced g(-1) H(2)S removed. Respirometric tests showed that heterotrophic activity is inhibited at low pH (pH < 2.3), and the contribution to biomass removal through decay was negligible.

  5. Biosyngas Fischer. Tropsch conversion by high Fe loaded supported catalysts prepared with ultrasound and microwave

    Energy Technology Data Exchange (ETDEWEB)

    Pirola, C.; Di Fronzo, A.; Boffito, D.C.; Bianchi, C. [Milano Univ. (Italy). Dipt. di Chimica; Di Michele, A. [Perugia Univ. (Italy). Dipt. di Fisica

    2012-07-01

    Catalysts with iron high loading of 30 wt%, promoted with K (2.0 wt%) and Cu (3.75 wt%), have been synthesized according to three different methods: (1) the traditional impregnation method (TR); (2) Ultrasound (US) assisted TR method; (3) Microwave (MW) assisted TR method. All the samples have been fully characterized by BET, ICP/OES, XRPD, TG-DTA, FT-IR, TPR, SEM and TEM and tested in a laboratory pilot plant for Fischer-Tropsch synthesis working at 220 C and 20 bar. The results of the catalysts characterization indicated that the morphology of the samples strongly depends on the method of preparation. The best FTS results in term of C{sub 2+} yield (41%) has been obtained using MW with a good value of the selectivity towards heavy hydrocarbons, while in term of CO conversion (58%), using US. The samples prepared with non-traditional methods show FTS better results, probably due to a more wide and uniform distribution of Fe in the medium during the synthesis phase. (orig.)

  6. Effect of blade tip winglet on the performance of a highly loaded transonic compressor rotor

    Institute of Scientific and Technical Information of China (English)

    Han Shaobing; Zhong Jingjun

    2016-01-01

    The tip leakage flow has an important influence on the performance of transonic com-pressor. Blade tip winglet has been proved to be an effective method to control the tip leakage flow in compressor, while the physical mechanisms of blade tip winglet have been poorly understood. A numerical study for a highly loaded transonic compressor rotor has been conducted to understand the effect of varying the location of blade tip winglet on the performance of the rotor. Two kinds of tip winglet were designed and investigated. The effects of blade tip winglet on the compressor over-all performance, stability and tip flow structure were presented and discussed. It is found that the interaction of the tip winglet with the flow in the tip region is different when the winglet is located at suction-side or pressure-side of the blade tip. Results indicate that the suction-side winglet (SW) is ineffective to improve the performance of compressor rotor. In addition, a significant stall range extension equivalent to 33.74% with a very small penalty in efficiency can be obtained by the pressure-side winglet (PW). An attempt has been made to explain the fundamental mechanisms of blade tip winglet in detail.

  7. Flow performance of highly loaded axial fan with bowed rotor blades

    Science.gov (United States)

    Chen, L.; Liu, X. J.; Yang, A. L.; Dai, R.

    2013-12-01

    In this paper, a partial bowed rotor blade was proposed for a newly designed high loaded axial fan. The blade was positively bowed 30 degrees from hub to 30 percent spanwise position. Flows of radial blade and bowed blade fans were numerically compared for various operation conditions. Results show that the fan's performance is improved. At the designed condition with flow coefficient of 0.52, the efficiency of the bowed blade fan is increased 1.44% and the static pressure rise is increased 11%. Comparing the flow structures, it can be found that the separated flow in the bowed fan is reduced and confined within 20 percent span, which is less than the 35 percent in the radial fan. It means that the bowed blade generates negative blade force and counteracts partial centrifugal force. It is alleviates the radial movements of boundary layers in fan's hub region. Flow losses due to 3D mixing are reduced in the rotor. Inlet flow to downstream stator is also improved.

  8. Topological analysis of plasma flow control on corner separation in a highly loaded compressor cascade

    Institute of Scientific and Technical Information of China (English)

    Xiao-Hu Zhao; Yun Wu; Ying-Hong Li; Xue-De Wang; Qin Zhao

    2012-01-01

    In this paper,flow behavior and topology structure in a highly loaded compressor cascade with and without plasma aerodynamic actuation (PAA) are investigated.Streamline pattern,total pressure loss coefficient,outlet flow angle and topological analysis are considered to study the effect and mechanism of the plasma flow control on corner separation.Results presented include the boundary layer flow behavior,effects of three types of PAA on separated flows and performance parameters,topology structures and sequences of singular points with and without PAA.Two separation lines,reversed flow and backflow exist on the suction surface.The cross flow on the endwall is an important element for the corner separation.PAA can reduce the undertuming and overturning as well as the total pressure loss,leading to an overall increase of flow turning and enhancement of aerodynamic performance.PAA can change the topology structure,sequences of singular points and their corresponding separation lines.Types Ⅱ and Ⅲ PAA are much more efficient in controlling corner separation and enhancing aerodynamic performances than type Ⅰ.

  9. Study on docetaxel-loaded nanoparticles with high antitumor efficacy against malignant melanoma

    Institute of Scientific and Technical Information of China (English)

    Donghui Zheng; Xiaolin Li; Huae Xu; Xiaowei Lu; Yong Hu; Weixin Fan

    2009-01-01

    Docetaxel (Doc) has extraordinary activities against a variety of solid tumors.However,the clinical efficacy of Doc is limited due to its poor solubility,low selective dis-tribution,fast elimination in vivo,etc.In the present study,Doc was incorporated into the core-shell structure of nanoparticles prepared based on our previous work.The obtained docetaxel-loaded nanoparticles (DOCNP) were characterized with various biophysical method-ologies,and its antitumor efficacy against malignant mel-anoma was evaluated both in vitro and in vivo.Our results indicated that Doc could be incorporated into the nanoparticles with high encapsulation efficiency (>90%).The incorporated Doc can be released from DOCNP in a sustained manner.In vitro cytotoxicity studies indicated that DOCNP could effectively kill B16 cells and show a dose- and time-dependent efficacy.Furthermore,intratu-moral administration revealed that DOCNP has signifi-cantly higher antitumor effect and lower toxicity to normal cells and tissues than free Doc.These results suggest that DOCNP may be a promising drug delivery system in therapy for malignant melanoma.

  10. Removal and retention of phosphorus by periphyton from wastewater with high organic load.

    Science.gov (United States)

    Cao, Jinxiang; Hong, Xiaoxing; Pei, Guofeng

    2014-01-01

    The total phosphorus (TP) removal efficiency from organic wastewater (pig farm and distillery wastewater) were estimated by using filamentous green algae (FGA) and benthic algal mats (BAM) treatment systems under laboratory conditions, and the contents of periphyton phosphorus fractions were determined by using a sequential extraction. The removal rates of TP reached 59-78% within the first 8 days of all treatment systems and could achieve average 80% during 30 day period, and the phosphorus removal rates by using BAM was higher than that of FGA. The ability of retention TP of periphyton enhanced gradually, the BAM TP contents were higher than that of FGA, the highest TP concentrations of BAM and FGA were 26.24 and 10.52 mg P g(-1)·dry weight. Inorganic phosphorus (IP) always exceeded 67.5% of TP, but the organic phosphorus fraction only made up less than 20% of TP. The calcium-binding phosphorus (Ca-P) was the dominant fraction and its relative contribution to TP was more than 40%. The TP was also strongly and positively correlated with the IP and Ca-P (p wastewater with high load phosphorus.

  11. Effect of dissolved oxygen concentration on the bioflocculation process in high loaded MBRs.

    Science.gov (United States)

    Faust, L; Temmink, H; Zwijnenburg, A; Kemperman, A J B; Rijnaarts, H H M

    2014-12-01

    High-loaded membrane bioreactors (HL-MBRs), i.e. MBRs which are operated at extremely short sludge and hydraulic retention times, can be applied to flocculate and concentrate sewage organic matter. The concentrated organics can be used for energy recovery, or for the production of more valuable organic chemicals. Little is known about the effect of the dissolved oxygen concentration (DO) on this bioflocculation process. To examine this effect, two HL-MBRs were operated, respectively at a low (1 mg L(-1)) and a higher (4 mg L(-1)) DO. The higher DO resulted in a better flocculation efficiency, i.e. 92% of the colloidal COD in the sewage flocculated compared to 69% at the lower DO. The difference was attributed to a higher microbial production of extracellular polymeric substances at a DO of 4 mg L(-1) and to more multivalent cations (calcium, iron and aluminium) being distributed to the floc matrix. In addition, the HL-MBR that was operated at a DO of 4 mg L(-1) gave a bigger mean floc size, a lower supernatant turbidity, better settleability and better membrane filterability than the HL-MBR that was operated at a DO of 1 mg L(-1). Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Tungsten joining with copper alloy and its high heat load performance

    Science.gov (United States)

    Liu, Xiang; Lian, Youyun; Chen, Lei; Cheng, Zengkui; Chen, Jiming; Duan, Xuru; Song, Jioupeng; Yu, Yang

    2014-12-01

    W-CuCrZr joining technology by using low activation Cu-Mn filler metal was developed at Southwestern Institute of Physics (SWIP) for the manufacturing of divertor components of fusion experiment devices. In addition, a fast W coating technology by chemical vapor deposition (CVD) was also developed and CVD-W/CuCrZr and CVD-W/C mockups with a W coating thickness of 2 mm were prepared. In order to assess their high heat flux (HHF) performances, a 60 kW Electron-beam Material testing Scenario (EMS-60) equipped with a 150 keV electron beam welding gun was constructed at SWIP. Experimental results indicated that brazed W/CuCrZr mockups can withstand 8 MW/m2 heat flux for 1000 cycles without visible damages and CVD-W/CuCrZr mockups with W-Cu gradient interface can survive 1000 cycles under 11 MW/m2 heat flux. An ultrasonic inspection method for non-destructive tests (NDT) of brazed W/CuCrZr mockups was established and 2 mm defect can be detected. Infinite element analysis and heat load tests indicated that 5 mm defect had less noticeable influence on the heat transfer.

  13. [Glycemic, insulinemic index, glycemic load of soy beverage with low and high content of carbohydrates].

    Science.gov (United States)

    Torres y Torres, Nimbe; Palacios-González, Berenice; Noriega-López, Lilia; Tovar-Palacio, Armando R

    2006-01-01

    Consumption of soy has increased in Western countries due to the benefits on health and the attitude of the people to consume natural products as alternative to the use of pharmacological therapies. However, there is no evidence whether the consumption of 25 g of soy protein as recommended by the Food and Drug Administration has some effect on glucose absorption and consequently on insulin secretion. The aim of the present study was to determine glycemic index (GI), insulinemic index (InIn), and glycemic load (GL) of several soy beverages containing low or high concentration of carbohydrates, and compare them with other foods such as peanuts, whole milk, soluble fiber and a mixed meal on GI and InIn. The results showed that soy beverages had low or moderate GI, depending of the presence of other compounds like carbohydrates and fiber. Consumption of soy beverages with low concentration of carbohydrates produced the lowest insulin secretion. Therefore, these products can be recommended in obese and diabetic patients. Finally soy beverages should contain low maltodextrins concentration and be added of soluble fiber.

  14. Loading Analysis of Modular Multi-level Converter for Offshore High-voltage DC Application under Various Grid Faults

    DEFF Research Database (Denmark)

    Liu, Hui; Ma, Ke; Loh, Poh Chiang;

    2016-01-01

    The modular multi-level converter has become an interesting candidate in high-voltage DC systems due to its higher voltage levels and modular construction. Low-voltage ride-through is an important grid requirement for modular multi-level converter–high-voltage DC since not only causes control...... challenges but may also result in overstressed components for the modular multi-level converter. However, the thermal loading of the modular multi-level converter under various grid faults has not yet been clarified. In this article, the power loss and thermal performance of the modular multi-level converter...... during grid voltage dips are studied. The impacts of two typical grid faults to the modular multi-level converter in terms of operating and loading conditions are analytically researched and simulated. It has been found that the operating and loading conditions of the modular multi-level converter under...

  15. A Novel Sensor System for Measuring Wheel Loads of Vehicles on Highways.

    Science.gov (United States)

    Zhang, Wenbin; Suo, Chunguang; Wang, Qi

    2008-12-02

    With the development of the highway transportation and business trade, vehicle Weigh-In-Motion (WIM) technology has become a key technology for measuring traffic loads. In this paper a novel WIM system based on monitoring of pavement strain responses in rigid pavement was investigated. In this WIM system multiple low cost, light weight, small volume and high accuracy embedded concrete strain sensors were used as WIM sensors to measure rigid pavement strain responses. In order to verify the feasibility of the method, a system prototype based on multiple sensors was designed and deployed on a relatively busy freeway. Field calibration and tests were performed with known two-axle truck wheel loads and the measurement errors were calculated based on the static weights measured with a static weighbridge. This enables the weights of other vehicles to be calculated from the calibration constant. Calibration and test results for individual sensors or three-sensor fusions are both provided. Repeatability, sources of error, and weight accuracy are discussed. Successful results showed that the proposed method was feasible and proven to have a high accuracy. Furthermore, a sample mean approach using multiple fused individual sensors could provide better performance compared to individual sensors.

  16. A Novel Sensor System for Measuring Wheel Loads of Vehicles on Highways

    Directory of Open Access Journals (Sweden)

    Wenbin Zhang

    2008-12-01

    Full Text Available With the development of the highway transportation and business trade, vehicle Weigh-In-Motion (WIM technology has become a key technology for measuring traffic loads. In this paper a novel WIM system based on monitoring of pavement strain responses in rigid pavement was investigated. In this WIM system multiple low cost, light weight, small volume and high accuracy embedded concrete strain sensors were used as WIM sensors to measure rigid pavement strain responses. In order to verify the feasibility of the method, a system prototype based on multiple sensors was designed and deployed on a relatively busy freeway. Field calibration and tests were performed with known two-axle truck wheel loads and the measurement errors were calculated based on the static weights measured with a static weighbridge. This enables the weights of other vehicles to be calculated from the calibration constant. Calibration and test results for individual sensors or three-sensor fusions are both provided. Repeatability, sources of error, and weight accuracy are discussed. Successful results showed that the proposed method was feasible and proven to have a high accuracy. Furthermore, a sample mean approach using multiple fused individual sensors could provide better performance compared to individual sensors.

  17. Significant progression of load on the musculoskeletal system with extremely high loads, with rapid weekly weight gains, using the Anatoly Gravitational System, in a 10-week training period

    Directory of Open Access Journals (Sweden)

    Burke DT

    2013-10-01

    Full Text Available David T Burke,1 David Tran,1 Di Cui,1 Daniel P Burke,2 Samir Al-Adawi,3 Atsu SS Dorvlo41Emory University Medical School, Atlanta, GA, USA; 2Georgia College and State University, GA, USA; 3Department of Behavioral Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman; 4Department of Mathematics and Statistics, College of Science, Sultan Qaboos University, Muscat, OmanAbstract: In an age of increasing numbers of lifestyle diseases and plasticity of longevity, exercise and weight training have been increasingly recognized as both preventing and mitigating the severity of many illnesses. This study was designed to determine whether significant weight-lifting gains could be realized through the Anatoly Gravitational System. Specifically, this study sought to determine whether this once-weekly weight-training system could result in significant weekly strength gains during a 10-week training period. A total of 50 participants, ranging in age from 17 to 67 years, completed at least 10 weekly 30-minute training sessions. The results suggest participants could, on average, double their weight-lifting capacity within 10 sessions. This preliminary study, which would require further scrutiny, suggests the Anatoly Gravitational System provides a rather unique opportunity to load the musculoskeletal system with extremely high loads, with rapid weekly weight gains, using only short weekly training sessions. More studies are warranted to scrutinize these findings.Keywords: Anatoly Gravitational System, weight training, musculoskeletal system

  18. A high loading overland flow system: Impacts on soil characteristics, grass constituents, yields and nutrient removal.

    Science.gov (United States)

    Wen, C G; Chen, T H; Hsu, F H; Lu, C H; Lin, J B; Chang, C H; Chang, S P; Lee, C S

    2007-04-01

    The objectives of this paper are to determine effects of different grass species and their harvests on pollutant removal, elucidate impacts on soil characteristics and grass constituents, observe grass yield and quantify nutrient uptake by vegetation in an overland flow system (OLFS). Polluted creek water was applied to eight channels in the OLFS, which were planted with Paragrass, Nilegrass, Cattail, and Vetiver, with each two channels being randomly planted with a given grass species. The grass in one channel was harvested while that in the other channel was not. At a high rate of 27.8 m d(-1) hydraulic loading, the removal efficiencies of conventional pollutants such as BOD, COD, suspended solids (SS), and total coliforms in wastewater are not affected by the type of the grasses species, but those of nitrogen and phosphorus are affected by different species. Overall average removal efficiencies of BOD, COD, SS, ammonia, total nitrogen, total phosphorus and total coliforms through the OLFS are 42%, 48%, 78%, 47%, 40%, 33% and 89%, respectively. The concentration of nitrate, however, increases due to nitrification. Soil characteristics in OLFS have been changed significantly; specific conductivity, organic matter, exchangeable magnesium, extractable copper and zinc in soils all increase with time while pHs decrease. During the winter season, there is a significant accumulation of nitrate in grass with the subsequent reduction during the active growing season (Spring). The contents of nitrate and phosphorus in grass tissue are higher than those of grass in general pastureland, probably due to nutrient luxury uptake by grass. The overall grass yield, growth rate and nutrient uptake are quantified and implication of such high rate OLFS discussed.

  19. Material Parameter Determination of an L4-L5 Motion Segment Finite Element Model Under High Loading Rates.

    Science.gov (United States)

    Pyles, C O; Zhang, J; Demetropoulos, C K; Bradfield, C A; Ott, K A; Armiger, R S; Merkle, A C

    2015-01-01

    Underbody blast (UBB) events impart vertical loads through a victim’s lumbar spine, resulting in fracture, paralysis, and disc rupture. Validated biofidelic lumbar models allow characterization of injury mechanisms and development of personal protective equipment. Previous studies have focused on lumbar mechanics under quasi-static loading. However, it is unclear how the role and response of individual spinal components of the lumbar spine change under dynamic loading. The present study leverages high-rate impacts of progressively dissected two-vertebra lumbar motion segments and Split-Hopkinson pressure bar tissue characterization to identify and validate material properties of a high-fidelity lumbar spine finite element model for UBB. The annulus fibrosus was modeled as a fiber-reinforced Mooney-Rivlin material, while ligaments were represented by nonlinear spring elements. Optimization and evaluation of material parameters was achieved by minimizing the root-mean-square (RMS) of compressive displacement and sagittal rotation for selected experimental conditions. Applying dynamic based material models and parameters resulted in a 0.42% difference between predicted and experiment axial compression during impact loading. This dynamically optimized lumbar model is suited for cross validation against whole-lumbar loading scenarios, and prediction of injury during UBB and other dynamic events.

  20. Load Torque Compensator for Model Predictive Direct Current Control in High Power PMSM Drive Systems

    DEFF Research Database (Denmark)

    Preindl, Matthias; Schaltz, Erik

    2010-01-01

    behaviour. It compensates the load torque influence on the speed control setting a feed forward torque value, i.e. current reference value. The benefits are twice. The speed controller reaches immediately the speed reference value avoiding offsets which must be compensated by the weak integrator. Moreover......, a better response to load torque variations which are detected and compensated leading to small speed variations is obtained....

  1. Tensile fracture and shear localization under high loading rate in tungsten alloys

    OpenAIRE

    Couque, H.; Lankford, J.; Bose, A

    1992-01-01

    The influence of loading rate and microstructure on the tensile and compressive failure properties of three microstructurally dissimilar tungsten alloys has been investigated. Dynamic tensile fracture properties were characterized through fracture toughness tests performed at a stress intensity loading rate of 106 MPa $\\sqrt{{\\rm m}}$ s-1, and by tensile testing at a strain rate of 103 s-1. Shear banding phenomena were investigated by means of compression tests performed at strain rates of 5 ...

  2. Optimization & Design of High Rise Building with Different Structural Framing Systems Subjected To Seismic Loads

    Directory of Open Access Journals (Sweden)

    Mr. Anant A. Kapse ,

    2014-06-01

    Full Text Available Due to excessive displacements of tall buildings occasioned by lateral loads, lateral load resisting systems are usually provided to curtail the load effect. The resistance may be offered by Frame Action, Shear Walls, or combined Walls and Frames (also known as Dual System. In this study, 3D structural modelling base software STAAD-PRO was used to generate and analyze three-dimensional building models for the assessment of the relative effectiveness of the various lateral load resisting systems. Five models were used, one for moment resisting frame & 04 models each for the lateral load resisting systems. Each model consisted of G +10 storey frame structure having total height of 33.0 m. Each building sample was subjected to three-dimensional analysis for the determination of both the lateral displacements at storey top and interstorey drifts. The results of the work showed that the dual system was the most efficient lateral-load resisting system based on deflection criterion, as they yielded the least values for lateral displacements and inter-storey drifts. The moment frame was the least stiff of the resisting systems, yielding the highest values of both the lateral displacement and the inter-storey drift.

  3. Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection.

    Directory of Open Access Journals (Sweden)

    Hea Young Oh

    Full Text Available PURPOSE: This prospective study aimed to examine the combined effect of viral load and alcohol consumption on the risk of persistent high-risk (HR human papillomavirus (HPV infection. METHODS: Among women undergoing health screening between 2002 and 2011 at the National Cancer Center, 284 and 122 women with HR-HPV infection and cytological findings of low-grade squamous intraepithelial or lower-grade lesions were followed up for 1 and 2 years, respectively. Multivariate logistic regression analysis was performed, and the relative excess risk due to interaction (RERI and synergy index (S were calculated. RESULTS: Among drinkers, the risks of 1-year (odds ratio [OR] 4.09, 95% confidence interval [CI] 2.05-8.18 and 2-year persistence (OR 8.08, CI 2.36-27.6 were significantly higher for high HPV loads than for low HPV loads; this association was not seen for non-drinkers. The risks for 1-year (OR 4.14, CI 1.89-9.05 and 2-year persistence (OR 6.61, CI 2.09-20.9 were significantly higher in subjects with a high HPV load who were also drinkers than in those who were non-drinkers. A high HPV load together with a longer drinking duration or higher alcohol consumption was associated with increased risks of 1-year (OR 3.07, CI 1.40-6.75 or OR 2.05, CI 0.87-4.83 and 2-year persistence (OR 6.40, CI 1.72-23.8 or OR 4.14, CI 1.18-14.6. The synergistic effect of alcohol consumption and HR-HPV load was stronger on the risk of 2-year persistence (RERI = 3.26, S = 2.38 than on the risk of 1-year persistence (RERI = 1.21, S = 1.63. CONCLUSIONS: The synergistic effect of HR-HPV load and alcohol consumption was associated with the risk of HR-HPV persistence and was stronger for longer-term HR-HPV infection. Limiting alcohol consumption might be an important measure to prevent the development of cervical cancer in women with a high HR-HPV load.

  4. A High-Power Low-Loss Continuously Tunable Bandpass Filter With Transversely Biased Ferrite-Loaded Coaxial Resonators

    DEFF Research Database (Denmark)

    Acar, Öncel; Johansen, Tom Keinicke; Zhurbenko, Vitaliy

    2015-01-01

    This paper presents a technology for high-power lowlosscontinuously tunable RF filters demonstrated by the exampleof a two-pole coupled-resonator filter. The resonators are shortenedcoaxial cavities loaded with ferrite inserts, where an externallyapplied transverse dc magnetic bias controls...

  5. Characterization of the bacterial community involved in the bioflocculation process of wastewater organic matter in high loaded MBRs

    NARCIS (Netherlands)

    Faust, L.; Szendy, M.; Plugge, C.M.; Brink, van den P.F.; Temmink, H.; Rijnaarts, H.H.M.

    2015-01-01

    High-loaded membrane bioreactors (HL-MBRs), i.e., bioreactors equipped with a membrane for biomass retention and operated at extremely short sludge and hydraulic retention times, can concentrate sewage organic matter to facilitate subsequent energy and chemical recovery from these organics. Bioflocc

  6. Relation between Breast Cancer and High Glycemic Index or Glycemic Load: A Meta-analysis of Prospective Cohort Studies.

    Science.gov (United States)

    Mullie, Patrick; Koechlin, Alice; Boniol, Mathieu; Autier, Philippe; Boyle, Peter

    2016-01-01

    Breast cancer is the commonest form of cancer in women worldwide. It has been suggested that chronic hyperinsulinemia associated with insulin resistance plays a role in breast cancer etiology. To test the hyperinsulinemia hypothesis, a dietary pattern associated with a high glycemic index and glycemic load, both proxies for chronic hyperinsulinemia, should be associated with an increased risk of breast cancer. A meta-analysis restricted to prospective cohort studies was undertaken using a random effects model with tests for statistical significance, publication bias and heterogeneity. The metric for analysis was the risk of breast cancer in the highest relative to the lowest glycemic index and glycemic load dietary pattern. A dietary pattern with a high glycemic index was associated with a summary relative risk (SRR) of 1.05 (95% CI: 1.00, 1.11), and a high glycemic load with a SRR of 1.06 (95% CI: 1.00, 1.13). Adjustments for body mass index [BMI], physical activity and other lifestyle factors did not influence the SRR, nor did menopausal status and estrogen receptor status of the tumor. In conclusion, the current evidence supports a modest association between a dietary pattern with high glycemic index or glycemic load and the risk of breast cancer.

  7. Consumption of a high glycemic load but not a high glycemic index diet is marginally associated with oxidative stress in young women.

    Science.gov (United States)

    Arikawa, Andrea Y; Jakits, Holly E; Flood, Andrew; Thomas, William; Gross, Myron; Schmitz, Kathryn H; Kurzer, Mindy S

    2015-01-01

    Research studies have suggested that chronic consumption of high glycemic index foods may lead to chronically high oxidative stress. This is important because oxidative stress is suspected to be an early event in the etiology of many disease processes. We hypothesized that dietary glycemic index and glycemic load were positively associated with oxidative stress assessed by plasma F2-isoprostanes in healthy, premenopausal women (body mass index [BMI] = 24.7 ± 4.8 kg/m(2) and age 25.3 ± 3.5 years, mean ± SD). We measured plasma F2-isoprostanes in 306 healthy premenopausal women at the baseline visit for the Women In Steady Exercise Research study, using gas chromatography-mass spectrometry. Dietary glycemic index and load were calculated from the National Cancer Institute Diet History Questionnaire, and participants were divided into quartiles of dietary glycemic index and of glycemic load. Plasma F2-isoprostanes were compared across quartile groups of dietary glycemic index and glycemic load using linear regression models. Plasma F2-isoprostanes (pg/mL) increased with quartile of glycemic load (test for linear trend, P = .033), and also increased with quartile of glycemic index in participants with BMI ≥ 25 (P = .035) but not in those with BMI glycemic index and P = .065 for quartiles of glycemic load).

  8. Recrystallization and grain growth behavior of rolled tungsten under VDE-like short pulse high heat flux loads

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Y. [Laboratory of Advanced Materials, Department of Material Science and Engineering, Tsinghua University, Beijing 100084 (China); Greuner, H.; Böswirth, B.; Krieger, K. [Max-Planck-Institut für Plasmaphysik, EURATOM Association, 85748 Garching (Germany); Luo, G.-N. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Xu, H.Y.; Fu, B.Q.; Li, M. [Laboratory of Advanced Materials, Department of Material Science and Engineering, Tsinghua University, Beijing 100084 (China); Liu, W., E-mail: liuw@mail.tsinghua.edu.cn [Laboratory of Advanced Materials, Department of Material Science and Engineering, Tsinghua University, Beijing 100084 (China)

    2013-02-15

    Highlights: ► Recrystallization temperature of a rolled W was ∼2480 °C under applied HHF loads. ► Fine grains were obtained under HHF loads with appropriate short pulse length. ► With increasing pulse length, the recrystallized grains significantly grew larger. ► A linear relationship between ln d and 1/T{sub max} was found. ► Activation energy for grain growth in T evolution up to T{sub max} in 1.5 s was obtained. -- Abstract: Short pulse heat loads expected for vertical displacement events (VDEs) in ITER were applied in the high heat flux (HHF) test facility GLADIS at IPP-Garching onto samples of rolled W. Pulsed neutral beams with the central heat flux of 23 MW/m{sup 2} were applied for 0.5, 1.0 and 1.5 s, respectively. Rapid recrystallization of the adiabatically loaded 3 mm thick samples was observed when the pulse duration was up to 1.0 s. Grains grew markedly following recrystallization with increasing pulse length. The recrystallization temperature and temperature dependence of the recrystallized grain size were also investigated. The results showed that the recrystallization temperature of the W grade was around 2480 °C under the applied heat loading condition, which was nearly 1150 °C higher than the conventional recrystallization temperature, and the grains were much finer. A linear relationship between the logarithm of average grain size (ln d) and the inverse of maximum surface temperature (1/T{sub max}) was found and accordingly the activation energy for grain growth in temperature evolution up to T{sub max} in 1.5 s of the short pulse HHF load was deduced to be 4.1 eV. This provided an effective clue to predict the structure evolution under short pulse HHF loads.

  9. Anaplasma marginale infection with persistent high-load bacteremia induces a dysfunctional memory CD4+ T lymphocyte response but sustained high IgG titers

    Science.gov (United States)

    Control of blood-borne infections is dependent on antigen-specific effector and memory T cells and high-affinity IgG responses. In chronic infections characterized by a high antigen load, it has been shown that antigen-specific T and B cells are vulnerable to downregulation and apoptosis. Anaplasma ...

  10. AP-2α regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase

    Directory of Open Access Journals (Sweden)

    Orso Francesca

    2009-05-01

    Full Text Available Abstract Background Neuronal migration is a crucial process that allows neurons to reach their correct target location to allow the nervous system to function properly. AP-2α is a transcription factor essential for neural crest cell migration and its mutation results in apoptosis within this cell population, as demonstrated by genetic models. Results We down-modulated AP-2α expression in GN-11 neurons by RNA interference and observe reduced neuron migration following the activation of a specific genetic programme including the Adhesion Related Kinase (Axl gene. We prove that Axl is able to coordinate migration per se and by ChIP and promoter analysis we observe that its transcription is directly driven by AP-2α via the binding to one or more functional AP-2α binding sites present in its regulatory region. Analysis of migration in AP-2α null mouse embryo fibroblasts also reveals an essential role for AP-2α in cell movement via the activation of a distinct genetic programme. Conclusion We show that AP-2α plays an essential role in cell movement via the activation of cell-specific genetic programmes. Moreover, we demonstrate that the AP-2α regulated gene Axl is an essential player in GN-11 neuron migration.

  11. High solids loading of aluminum nitride powder in epoxy resin: Dispersion and thermal conductivity

    Science.gov (United States)

    Lee, Eunsung

    Most semiconductor devices are now packaged in an epoxy polymer composite, which includes a silica powder filler for reducing the thermal expansion coefficient. However, increased heat output from near-future semiconductors will require higher thermal conductivity fillers such as aluminum nitride powder, instead of silica. This thesis research is intended to apply improved dispersant chemistry, in order to achieve a high volume percentage of AlN powder in epoxy, increasing the thermal conductivity of the composite without causing excessive viscosity before the epoxy monomer is crosslinked. In initial experiments, the dispersibility of aluminum oxide in epoxy monomer resin was better than that of AlN, because of the weaker basicity of oxide surfaces compared with nitride. To improve the dispersibility of AlN, its surface was modified by pretreatment with silane coupling agents. Silane molecules with different head groups were investigated. In those experiments, methylsilane gave lower viscosities than chloro- or methoxysilane, while pretreatments using organic acids increased the viscosity of the AlN dispersion. The viscosity changes and FTIR peak intensity trends suggested that the silane molecules could be adsorbed on AlN surfaces in the form of a monolayer during optimization experiments, and the best silane monolayer coverage on the AlN powder surfaces was achieved with 2 wt% amounts in a 3 hour treatment. A particular phosphate ester was a good second layer dispersant for the AlN-plus-epoxy system. When that dispersant was added onto the silane-treated filler surfaces, the degree of viscosity reduction was dependent on the types of silane coupling agent functional groups. In the optimized results, silane pretreatment followed by dispersant addition was better than either alone. High solids loading, up to 57 vol.%, was achieved with a wide particle size distribution of powder, and the viscosity of that dispersion was 60,000 to 90,000 cps, which easily flowed by

  12. Numerical Investigation of Flow Separation Control on a Highly Loaded Compressor Cascade by Plasma Aerodynamic Actuation

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xiaohu; LI Yinghong; WU Yun; ZHU Tao; LI Yiwen

    2012-01-01

    To discover the characteristic of separated flows and mechanism of plasma flow control on a highly loaded compressor cascade,numerical investigation is conducted.The simulation method is validated by oil flow visualization and pressure distribution.The loss coefficients,streamline patterns,and topology structure as well as vortex structure are analyzed.Results show thai the numbers of singular points increase and three pairs of additional singular points of topology structure on solid surface generate with the increase of angle of attack,and the total pressure loss increases greatly.There are several principal vortices inside the cascade passage.The pressure side leg of horse-shoe vortex coexists within a specific region together with passage vortex,but finally merges into the latter.Comer vortex exists independently and does not evolve from the suction side leg of horse-shoe vortex.One pair of radial coupling-vortex exists near blade trailing edge and becomes the main part of backflow on the suction surface.Passage vortex interacts with the concentrated shedding vortex and they evolve into a large-scale vortex rotating in the direction opposite to passage vortex.The singular points and separation lines represent the basic separation feature of cascade passage.Plasma actuation has better effect at low freestream velocity,and the relative reductions of pitch-averaged total pressure loss coefficient with different actuation layouts of five and two pairs of electrodes are up to 30.8% and 26.7% while the angle of attack is 2°.Plasma actuation changes the local topology structure,but does not change the number relation of singular points.One pair of additional singular point of topology structure generates with plasma actuation and one more reattachment line appears,both of which break the separation line on the suction surface.

  13. Potential for bioremediation of agro-industrial effluents with high loads of pesticides by selected fungi.

    Science.gov (United States)

    Karas, Panagiotis A; Perruchon, Chiara; Exarhou, Katerina; Ehaliotis, Constantinos; Karpouzas, Dimitrios G

    2011-02-01

    Wastewaters from the fruit packaging industry contain a high pesticide load and require treatment before their environmental discharge. We provide first evidence for the potential bioremediation of these wastewaters. Three white rot fungi (WRF) (Phanerochaete chrysosporium, Trametes versicolor, Pleurotus ostreatus) and an Aspergillus niger strain were tested in straw extract medium (StEM) and soil extract medium (SEM) for degrading the pesticides thiabendazole (TBZ), imazalil (IMZ), thiophanate methyl (TM), ortho-phenylphenol (OPP), diphenylamine (DPA) and chlorpyrifos (CHL). Peroxidase (LiP, MnP) and laccase (Lac) activity was also determined to investigate their involvement in pesticide degradation. T. versicolor and P. ostreatus were the most efficient degraders and degraded all pesticides (10 mg l⁻¹) except TBZ, with maximum efficiency in StEM. The phenolic pesticides OPP and DPA were rapidly degraded by these two fungi with a concurrent increase in MnP and Lac activity. In contrast, these enzymes were not associated with the degradation of CHL, IMZ and TM implying the involvement of other enzymes. T. versicolor degraded spillage-level pesticide concentrations (50 mg l⁻¹) either fully (DPA, OPP) or partially (TBZ, IMZ). The fungus was also able to rapidly degrade a mixture of TM/DPA (50 mg l⁻¹), whereas it failed to degrade IMZ and TBZ when supplied in a mixture with OPP. Overall, T. versicolor and P. ostreatus showed great potential for the bioremediation of wastewaters from the fruit packaging industry. However, degradation of TBZ should be also achieved before further scaling up.

  14. Biofiltration of high formaldehyde loads with ozone additions in long-term operation.

    Science.gov (United States)

    Maldonado-Diaz, G; Arriaga, S

    2015-01-01

    Formaldehyde (FA) biofiltration was evaluated over 310 days with and without ozone addition. Without ozone, the biofilter was able to treat formaldehyde at inlet loads (ILs) lower than 40 g m(-3) h(-1), maintaining, under this condition, an average removal efficiency (RE) of 88 % for a few days before collapsing to zero. The continuous addition of ozone (90 ppbv) helped to recover the RE from zero to 98 ± 2 % and made it possible to operate at an IL of 40 g m(-3) h(-1) for long periods of operation (107 days). Furthermore, the ozone addition aided in operating the biofilter at a formaldehyde IL of up to 120 g m(-3) h(-1) values that have never before been reached. GC-mass spectrometry (MS) analysis showed that dimethoxymethane was the common compound in leachate during the performance decay. Also, the addition of ozone aided in maintaining an optimal pH in the biofilter with values between 7.5 and 8.2, due to the carbonate species formed during the ozone reactions with formaldehyde and its by-products. Thus, the pH control was confirmed and the alkalinity of the biofilter increased from 334.1 ± 100.3 to 1450 ± 127 mg CaCO3 L(-1) when ozone was added. Ozone addition diminished the exopolymeric substances (EPS) content of biofilm and biofilm thickness without affecting cell viability. Kinetic parameters suggested that the best conditions for carrying out FA biofiltration were reached under ozone addition. The addition of ozone during formaldehyde biofiltration could be a good strategy to maintain the pH and the steady state of the system under high ILs and for long periods of operation.

  15. New Method to Prepare Mitomycin C Loaded PLA-Nanoparticles with High Drug Entrapment Efficiency

    Science.gov (United States)

    Hou, Zhenqing; Wei, Heng; Wang, Qian; Sun, Qian; Zhou, Chunxiao; Zhan, Chuanming; Tang, Xiaolong; Zhang, Qiqing

    2009-07-01

    The classical utilized double emulsion solvent diffusion technique for encapsulating water soluble Mitomycin C (MMC) in PLA nanoparticles suffers from low encapsulation efficiency because of the drug rapid partitioning to the external aqueous phase. In this paper, MMC loaded PLA nanoparticles were prepared by a new single emulsion solvent evaporation method, in which soybean phosphatidylcholine (SPC) was employed to improve the liposolubility of MMC by formation of MMC-SPC complex. Four main influential factors based on the results of a single-factor test, namely, PLA molecular weight, ratio of PLA to SPC (wt/wt) and MMC to SPC (wt/wt), volume ratio of oil phase to water phase, were evaluated using an orthogonal design with respect to drug entrapment efficiency. The drug release study was performed in pH 7.2 PBS at 37 °C with drug analysis using UV/vis spectrometer at 365 nm. MMC-PLA particles prepared by classical method were used as comparison. The formulated MMC-SPC-PLA nanoparticles under optimized condition are found to be relatively uniform in size (594 nm) with up to 94.8% of drug entrapment efficiency compared to 6.44 μm of PLA-MMC microparticles with 34.5% of drug entrapment efficiency. The release of MMC shows biphasic with an initial burst effect, followed by a cumulated drug release over 30 days is 50.17% for PLA-MMC-SPC nanoparticles, and 74.1% for PLA-MMC particles. The IR analysis of MMC-SPC complex shows that their high liposolubility may be attributed to some weak physical interaction between MMC and SPC during the formation of the complex. It is concluded that the new method is advantageous in terms of smaller size, lower size distribution, higher encapsulation yield, and longer sustained drug release in comparison to classical method.

  16. Metasurface Reflector (MSR) Loading for High Performance Small Microstrip Antenna Design.

    Science.gov (United States)

    Ahsan, Md Rezwanul; Islam, Mohammad Tariqul; Ullah, Mohammad Habib; Singh, Mandeep Jit; Ali, Mohd Tarmizi

    2015-01-01

    A meander stripline feed multiband microstrip antenna loaded with metasurface reflector (MSR) structure has been designed, analyzed and constructed that offers the wireless communication services for UHF/microwave RFID and WLAN/WiMAX applications. The proposed MSR assimilated antenna comprises planar straight forward design of circular shaped radiator with horizontal slots on it and 2D metasurface formed by the periodic square metallic element that resembles the behavior of metamaterials. A custom made high dielectric bio-plastic substrate (εr = 15) is used for fabricating the prototype of the MSR embedded planar monopole antenna. The details of the design progress through numerical simulations and experimental results are presented and discussed accordingly. The measured impedance bandwidth, radiation patterns and gain of the proposed MSR integrated antenna are compared with the obtained results from numerical simulation, and a good compliance can be observed between them. The investigation shows that utilization of MSR structure has significantly broadened the -10 dB impedance bandwidth than the conventional patch antenna: from 540 to 632 MHz (17%), 467 to 606 MHz (29%) and 758 MHz to 1062 MHz (40%) for three distinct operating bands centered at 0.9, 3.5 and 5.5 GHz. Additionally, due to the assimilation of MSR, the overall realized gains have been upgraded to a higher value of 3.62 dBi, 6.09 dBi and 8.6 dBi for lower, middle and upper frequency band respectively. The measured radiation patterns, impedance bandwidths (S11antenna prototype exhibit reasonable characteristics that can satisfy the requirements of UHF/microwave (5.8 GHz) RFID, WiMAX (3.5/5.5 GHz) and WLAN (5.2/5.8 GHz) applications.

  17. Observations on the effects of grooved surfaces on the interfacial torque in highly loaded rolling and sliding tests

    DEFF Research Database (Denmark)

    Janakiraman, Shravan; Klit, Peder; Jensen, Niels Steenfeldt;

    2014-01-01

    Some efforts have been undertaken to study the effects of grooved surfaces on the interfacial film thickness and torque between two contacting non-conformal surfaces under heavy loads. Transverse grooves of micrometer scale depth were engraved on polished, flat ring surfaces using established...... industrial methods like laser engraving and wire cutting. The grooved surfaces were then run against a polished flat surface at loads corresponding to