WorldWideScience

Sample records for high availability requirement

  1. High availability IT services

    CERN Document Server

    Critchley, Terry

    2014-01-01

    This book starts with the basic premise that a service is comprised of the 3Ps-products, processes, and people. Moreover, these entities and their sub-entities interlink to support the services that end users require to run and support a business. This widens the scope of any availability design far beyond hardware and software. It also increases the potential for service failure for reasons beyond just hardware and software; the concept of logical outages. High Availability IT Services details the considerations for designing and running highly available ""services"" and not just the systems

  2. Proxmox high availability

    CERN Document Server

    Cheng, Simon MC

    2014-01-01

    If you want to know the secrets of virtualization and how to implement high availability on your services, this is the book for you. For those of you who are already using Proxmox, this book offers you the chance to build a high availability cluster with a distributed filesystem to further protect your system from failure.

  3. High Availability Electronics Standards

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, R.S.; /SLAC

    2006-12-13

    Availability modeling of the proposed International Linear Collider (ILC) predicts unacceptably low uptime with current electronics systems designs. High Availability (HA) analysis is being used as a guideline for all major machine systems including sources, utilities, cryogenics, magnets, power supplies, instrumentation and controls. R&D teams are seeking to achieve total machine high availability with nominal impact on system cost. The focus of this paper is the investigation of commercial standard HA architectures and packaging for Accelerator Controls and Instrumentation. Application of HA design principles to power systems and detector instrumentation are also discussed.

  4. JUNOS High Availability

    CERN Document Server

    Sonderegger, James; Milne, Kieran; Palislamovic, Senad

    2009-01-01

    Whether your network is a complex carrier or just a few machines supporting a small enterprise, JUNOS High Availability will help you build reliable and resilient networks that include Juniper Networks devices. With this book's valuable advice on software upgrades, scalability, remote network monitoring and management, high-availability protocols such as VRRP, and more, you'll have your network uptime at the five, six, or even seven nines -- or 99.99999% of the time. Rather than focus on "greenfield" designs, the authors explain how to intelligently modify multi-vendor networks. You'll learn

  5. High availability using virtualization

    CERN Document Server

    Calzolari, Federico

    2009-01-01

    High availability has always been one of the main problems for a data center. Till now high availability was achieved by host per host redundancy, a highly expensive method in terms of hardware and human costs. A new approach to the problem can be offered by virtualization. Using virtualization, it is possible to achieve a redundancy system for all the services running on a data center. This new approach to high availability allows to share the running virtual machines over the servers up and running, by exploiting the features of the virtualization layer: start, stop and move virtual machines between physical hosts. The system (3RC) is based on a finite state machine with hysteresis, providing the possibility to restart each virtual machine over any physical host, or reinstall it from scratch. A complete infrastructure has been developed to install operating system and middleware in a few minutes. To virtualize the main servers of a data center, a new procedure has been developed to migrate physical to virtu...

  6. Introducing high availability to non high available designed applications

    Energy Technology Data Exchange (ETDEWEB)

    Zelnicek, Pierre; Kebschull, Udo [Kirchhoff Institute of Physics, Ruprecht-Karls-University Heidelberg (Germany); Haaland, Oystein Senneset [Physic Institut, University of Bergen, Bergen (Norway); Lindenstruth, Volker [Frankfurt Institut fuer Advanced Studies, University Frankfurt (Germany)

    2010-07-01

    A common problem in scientific computing environments and compute clusters today, is how to apply high availability to legacy applications. These applications are becoming more and more a problem in increasingly complex environments and with business grade availability constraints that requires 24 x 7 x 365 hours of operation. For a majority of applications, redesign is not an option. Either because of being closed source or the effort involved would be just as great as re-writing the application from scratch. Neither is letting normal operators restart and reconfigure the applications on backup nodes a solution. In addition to the possibility of mistakes from non-experts and the cost of keeping personnel at work 24/7, these kind of operations would require administrator privileges within the compute environment and would therefore be a security risk. Therefore, these legacy applications have to be monitored and if a failure occurs autonomously migrated to a working node. The pacemaker framework is designed for both tasks and ensures the availability of the legacy applications. Distributed redundant block devices are used for fault tolerant distributed data storage. The result is an Availability Environment Classification 2 (AEC-2).

  7. MongoDB high availability

    CERN Document Server

    Mehrabani, Afshin

    2014-01-01

    This book has a perfect balance of concepts and their practical implementation along with solutions to make a highly available MongoDB server with clear instructions and guidance. If you are using MongoDB in a production environment and need a solution to make a highly available MongoDB server, this book is ideal for you. Familiarity with MongoDB is expected so that you understand the content of this book.

  8. Enabling High Data Availability in a DHT

    NARCIS (Netherlands)

    Knezevic, Predrag; Wombacher, Andreas; Risse, Thomas

    Many decentralized and peer-to-peer applications require some sort of data management. Besides P2P file-sharing, there are already scenarios (e.g. BRICKS project) that need management of finer-grained objects including updates and, keeping them highly available in very dynamic communities of peers.

  9. Microsoft Exchange Server 2013 high availability

    CERN Document Server

    Mota, Nuno

    2014-01-01

    This book is a hands-on practical guide that provides the reader with a number of clear scenarios and examples, making it easier to understand and apply the new concepts. Each chapter can be used as a reference, or it can be read from beginning to end, allowing consultants/administrators to build a solid and highly available Exchange 2013 environment. If you are a messaging professional who wants to learn to design a highly available Exchange 2013 environment, this book is for you. Although not a definite requirement, practical experience with Exchange 2010 is expected, without being a subject

  10. High Available COTS Based Computer for Space

    Science.gov (United States)

    Hartmann, J.; Magistrati, Giorgio

    2015-09-01

    The availability and reliability factors of a system are central requirements of a target application. From a simple fuel injection system used in cars up to a flight control system of an autonomous navigating spacecraft, each application defines its specific availability factor under the target application boundary conditions. Increasing quality requirements on data processing systems used in space flight applications calling for new architectures to fulfill the availability, reliability as well as the increase of the required data processing power. Contrary to the increased quality request simplification and use of COTS components to decrease costs while keeping the interface compatibility to currently used system standards are clear customer needs. Data processing system design is mostly dominated by strict fulfillment of the customer requirements and reuse of available computer systems were not always possible caused by obsolescence of EEE-Parts, insufficient IO capabilities or the fact that available data processing systems did not provide the required scalability and performance.

  11. Data requirements, availability and gaps in AEIs in Europe

    DEFF Research Database (Denmark)

    Vinther, Finn Pilgaard; Kudsk, Per Nielsen; Hutchings, Nicholas John

    Agriculture exerts various effects on the environment. These effects depend on both the agricultural activities and the environmental conditions. Agriculture in the European Union (EU) is highly diverse and also dynamic, as agriculture responds to changes in markets, technological developments...... and governmental policy. As a consequence, effects of agriculture on the environment are spatially diverse and change over time. To evaluate the responses to changes in markets, technological developments and governmental policy over time, a set of 32 Agri-Environmental Indicators (AEIs) has been developed...... covering a wide range of agricultural variables that affect the environment. The general objectives of task 1 of the DireDate project are to (i) define and describe the AEIs, with special focus on identification of data requirements, availability and gaps in AEIs and (ii) indentify the relationships...

  12. Space Transportation System Availability Requirements and Its Influencing Attributes Relationships

    Science.gov (United States)

    Rhodes, Russell E.; Adams, Timothy C.; McCleskey, Carey M.

    2008-01-01

    It is important that engineering and management accept the need for an availability requirement that is derived with its influencing attributes. It is the intent of this paper to provide the visibility of relationships of these major attribute drivers (variables) to each other and the resultant system inherent availability. Also important to provide bounds of the variables providing engineering the insight required to control the system's engineering solution, e.g., these influencing attributes become design requirements also. These variables will drive the need to provide integration of similar discipline functions or technology selection to allow control of the total parts count. The relationship of selecting a reliability requirement will place a constraint on parts count to achieve a given availability requirement or if allowed to increase the parts count will drive the system reliability requirement higher. They also provide the understanding for the relationship of mean repair time (or mean down time) to maintainability, e.g., accessibility for repair, and both the mean time between failure, e.g., reliability of hardware and availability. The concerns and importance of achieving a strong availability requirement is driven by the need for affordability, the choice of using the two launch solution for the single space application, or the need to control the spare parts count needed to support the long stay in either orbit or on the surface of the moon. Understanding the requirements before starting the architectural design concept will avoid considerable time and money required to iterate the design to meet the redesign and assessment process required to achieve the results required of the customer's space transportation system. In fact the impact to the schedule to being able to deliver the system that meets the customer's needs, goals, and objectives may cause the customer to compromise his desired operational goal and objectives resulting in considerable

  13. Space Transportation System Availability Requirement and Its Influencing Attributes Relationships

    Science.gov (United States)

    Rhodes, Russell E.; Adams, Timothy C.; McCleskey, Carey M.

    2008-01-01

    It is important that engineering and management accept the need for an availability requirement that is derived with its influencing attributes. It is the intent of this paper to provide the visibility of relationships of these major attribute drivers (variables) to each other and the resultant system inherent availability. Also important to provide bounds of the variables providing engineering the insight required to control the system's engineering solution, e.g., these influencing attributes become design requirements also. These variables will drive the need to provide integration of similar discipline functions or technology selection to allow control of the total parts count. The relationship of selecting a reliability requirement will place a constraint on parts count to achieve a given availability requirement or if allowed to increase the parts count will drive the system reliability requirement higher. They also provide the understanding for the relationship of mean repair time (or mean down time) to maintainability, e.g., accessibility for repair, and both the mean time between failure, e.g., reliability of hardware and availability. The concerns and importance of achieving a strong availability requirement is driven by the need for affordability, the choice of using the two launch solution for the single space application, or the need to control the spare parts count needed to support the long stay in either orbit or on the surface of the moon. Understanding the requirements before starting the architectural design concept will avoid considerable time and money required to iterate the design to meet the redesign and assessment process required to achieve the results required of the customer's space transportation system. In fact the impact to the schedule to being able to deliver the system that meets the customer's needs, goals, and objectives may cause the customer to compromise his desired operational goal and objectives resulting in considerable

  14. Space Transportation System Availability Requirements and Its Influencing Attributes Relationships

    Science.gov (United States)

    Rhodes, Russel E.; Adams, TImothy C.

    2008-01-01

    It is essential that management and engineering understand the need for an availability requirement for the customer's space transportation system as it enables the meeting of his needs, goal, and objectives. There are three types of availability, e.g., operational availability, achieved availability, or inherent availability. The basic definition of availability is equal to the mean uptime divided by the sum of the mean uptime plus the mean downtime. The major difference is the inclusiveness of the functions within the mean downtime and the mean uptime. This paper will address tIe inherent availability which only addresses the mean downtime as that mean time to repair or the time to determine the failed article, remove it, install a replacement article and verify the functionality of the repaired system. The definitions of operational availability include the replacement hardware supply or maintenance delays and other non-design factors in the mean downtime. Also with inherent availability the mean uptime will only consider the mean time between failures (other availability definitions consider this as mean time between maintenance - preventive and corrective maintenance) that requires the repair of the system to be functional. It is also essential that management and engineering understand all influencing attributes relationships to each other and to the resultant inherent availability requirement. This visibility will provide the decision makers with the understanding necessary to place constraints on the design definition for the major drivers that will determine the inherent availability, safety, reliability, maintainability, and the life cycle cost of the fielded system provided the customer. This inherent availability requirement may be driven by the need to use a multiple launch approach to placing humans on the moon or the desire to control the number of spare parts required to support long stays in either orbit or on the surface of the moon or mars. It is

  15. 40 CFR 51.1010 - Requirements for reasonably available control technology (RACT) and reasonably available control...

    Science.gov (United States)

    2010-07-01

    ... control technology (RACT) and reasonably available control measures (RACM). 51.1010 Section 51.1010... PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Provisions for Implementation of PM2.5 National Ambient Air Quality Standards § 51.1010 Requirements for reasonably available control technology...

  16. High availability of hybrid wireless networks

    Science.gov (United States)

    Leitgeb, Erich; Gebhart, Michael; Birnbacher, Ulla; Kogler, Wolfgang; Schrotter, Peter

    2004-09-01

    Free Space Optical (FSO) links offer high bandwidth and the flexibility of wireless communication links. However, the availability of FSO links is limited by weather patterns like fog and heavy snowfall. Microwave based communication links operating at high frequencies (40 - 43 GHz) have similar characteristics like high data rates and needed line-of-sight. Link availability for microwave systems is limited by heavy rain. Combining FSO links with microwave links within a hybrid FSO/microwave communication network has the advantage of added redundancy and higher link availability. Measurements over a period of one year show a combined availability of 99.93% for the climatic region of Graz, Austria) which proves that the combination of both technologies leads to a highly available wireless connection offering high bandwidth.

  17. Data requirements, availability and gaps in AEIs in Europe

    DEFF Research Database (Denmark)

    Vinther, Finn Pilgaard; Kudsk, Per Nielsen; Hutchings, Nicholas John

    covering a wide range of agricultural variables that affect the environment. The general objectives of task 1 of the DireDate project are to (i) define and describe the AEIs, with special focus on identification of data requirements, availability and gaps in AEIs and (ii) indentify the relationships...... between the AEIs and between AEIs and data requirements for agri-environmental policies. This report presents factsheets with descriptions of the 32 AEIs selected by the European Commission. Following the suggestion of Eurostat, a distinction was made between two sets of AEIs; here termed the first...... to be derived from the farm or at farm level. In contrast, the second set of AEIs are not all yet fully defined and developed, and the data required are derived, in general, from sources other than at farm level....

  18. A Highly Available Grid Metadata Catalog

    DEFF Research Database (Denmark)

    Jensen, Henrik Thostrup; Kleist, Joshva

    2009-01-01

    This article presents a metadata catalog, intended foruse in grids. The catalog provides high availability, by replication across several hosts. The replicas are kept consistent using a replication protocol based on the Paxos algorithm. A majority of the replicas must be available in order...... for the system to function. The data model used in the catalog is RDF, which allows users to create theirown name spaces and schemas. Querying is performed using SPARQL. Additionally the catalog can be used as a synchronization mechanism, by utilizing a compare and swap operation. The catalog is accessed using...... HTTP with proxy certificates, and uses GACL for flexible access control.The performance of the catalog is tested in several ways, including a distributed setup between geographically separated sites....

  19. Digitally Controlled High Availability Power Supply

    Energy Technology Data Exchange (ETDEWEB)

    MacNair, David; /SLAC

    2009-05-07

    This paper will report on the test results of a prototype 1320 watt power module for a high availability power supply. The module will allow parallel operation for N+1 redundancy with hot swap capability. The two quadrant output of each module allows pairs of modules to provide a 4 quadrant (bipolar) operation. Each module employs a novel 4 FET buck regulator arranged in a bridge configuration. Each side of the bridge alternately conducts through a small saturable ferrite that limits the reverse current in the FET body diode during turn off. This allows hard switching of the FETs with low switching losses. The module is designed with over-rated components to provide high reliability and better then 97% efficiency at full load. The modules use a Microchip DSP for control, monitoring, and fault detection. The switching FETS are driven by PWM modules in the DSP at 60 KHz. A Dual CAN bus interface provides for low cost redundant control paths. The DSP will also provide current sharing between modules, synchronized switching, and soft start up for hot swapping. The input and output of each module have low resistance FETs to allow hot swapping and isolation of faulted units.

  20. Model and Implementation of Communication Link Management Supporting High Availability

    Institute of Scientific and Technical Information of China (English)

    Luo Juan; Cao Yang; He Zheng; Li Feng

    2004-01-01

    Despite the rapid evolution in all aspects of computer technology, both the computer hardware and software are prone to numerous failure conditions. In this paper, we analyzed the characteristic of a computer system and the methods of constructing a system , proposed a communication link management model supporting high availability for network applications, Which will greatly increase the high availability of network applications. Then we elaborated on heartbeat or service detect, fail-over, service take-over, switchback and error recovery process of the model. In the process of constructing the communication link, we implemented the link management and service take-over with high availability requirement, and discussed the state and the state transition of building the communication link between the hosts, depicted the message transfer and the start of timer. At Last, we applied the designed high availability system to a network billing system, and showed how the system was constructed and implemented, which perfectly satisfied the system requirements.

  1. Achieving a System Operational Availability Requirement (ASOAR) Model

    Science.gov (United States)

    1992-07-01

    ASOAR requires only system and end item level input data, not Line Replaceable Unit (LRU) Input data. ASOAR usage provides concepts for major logistics...the Corp/Theater ADP Service Center II (CTASC II) to a systen operational availabilty goal. The CTASC II system configuration had many redundant types

  2. Availability Analysis for High Voltage Synchronous Motor

    Institute of Scientific and Technical Information of China (English)

    DING Jin-hua; Erland Olsson; ZHOU Rong

    2004-01-01

    The operating experience data for 34 motors running for approximately 15 years in paper plants are collected. According to the data set, the reliability and availability characteristics of a highvoltage synchronous motor are analyzed based on the Markov Model. The unit or subsystem main rotor with windings in the motor system is more important for the motor system's availability, though its failure rate is lower compared to other units. Preventive maintenance is first introduced as a state in the markov Model for the motor system.

  3. PostgreSQL 9 high availability cookbook

    CERN Document Server

    Thomas, Shaun M

    2014-01-01

    A comprehensive series of dependable recipes to design, build, and implement a PostgreSQL server architecture free of common pitfalls that can operate for years to come. Each chapter is packed with instructions and examples to simplify even highly complex database operations. If you are a PostgreSQL DBA working on Linux systems who want a database that never gives up, this book is for you. If you've ever experienced a database outage, restored from a backup, spent hours trying to repair a malfunctioning cluster, or simply want to guarantee system stability, this book is definitely for you.

  4. A High-Availability, Distributed Hardware Control System Using Java

    Science.gov (United States)

    Niessner, Albert F.

    2011-01-01

    Two independent coronagraph experiments that require 24/7 availability with different optical layouts and different motion control requirements are commanded and controlled with the same Java software system executing on many geographically scattered computer systems interconnected via TCP/IP. High availability of a distributed system requires that the computers have a robust communication messaging system making the mix of TCP/IP (a robust transport), and XML (a robust message) a natural choice. XML also adds the configuration flexibility. Java then adds object-oriented paradigms, exception handling, heavily tested libraries, and many third party tools for implementation robustness. The result is a software system that provides users 24/7 access to two diverse experiments with XML files defining the differences

  5. A High-Availability, Distributed Hardware Control System Using Java

    Science.gov (United States)

    Niessner, Albert F.

    2011-01-01

    Two independent coronagraph experiments that require 24/7 availability with different optical layouts and different motion control requirements are commanded and controlled with the same Java software system executing on many geographically scattered computer systems interconnected via TCP/IP. High availability of a distributed system requires that the computers have a robust communication messaging system making the mix of TCP/IP (a robust transport), and XML (a robust message) a natural choice. XML also adds the configuration flexibility. Java then adds object-oriented paradigms, exception handling, heavily tested libraries, and many third party tools for implementation robustness. The result is a software system that provides users 24/7 access to two diverse experiments with XML files defining the differences

  6. Requirements on high resolution detectors

    Energy Technology Data Exchange (ETDEWEB)

    Koch, A. [European Synchrotron Radiation Facility, Grenoble (France)

    1997-02-01

    For a number of microtomography applications X-ray detectors with a spatial resolution of 1 {mu}m are required. This high spatial resolution will influence and degrade other parameters of secondary importance like detective quantum efficiency (DQE), dynamic range, linearity and frame rate. This note summarizes the most important arguments, for and against those detector systems which could be considered. This article discusses the mutual dependencies between the various figures which characterize a detector, and tries to give some ideas on how to proceed in order to improve present technology.

  7. 40 CFR 51.912 - What requirements apply for reasonably available control technology (RACT) and reasonably...

    Science.gov (United States)

    2010-07-01

    ... available control technology (RACT) and reasonably available control measures (RACM) under the 8-hour NAAQS... PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Provisions for... reasonably available control technology (RACT) and reasonably available control measures (RACM) under the...

  8. Purple Computational Environment With Mappings to ACE Requirements for the General Availability User Environment Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Barney, B; Shuler, J

    2006-08-21

    Purple is an Advanced Simulation and Computing (ASC) funded massively parallel supercomputer located at Lawrence Livermore National Laboratory (LLNL). The Purple Computational Environment documents the capabilities and the environment provided for the FY06 LLNL Level 1 General Availability Milestone. This document describes specific capabilities, tools, and procedures to support both local and remote users. The model is focused on the needs of the ASC user working in the secure computing environments at Los Alamos National Laboratory, Lawrence Livermore National Laboratory, and Sandia National Laboratories, but also documents needs of the LLNL and Alliance users working in the unclassified environment. Additionally, the Purple Computational Environment maps the provided capabilities to the Trilab ASC Computing Environment (ACE) Version 8.0 requirements. The ACE requirements reflect the high performance computing requirements for the General Availability user environment capabilities of the ASC community. Appendix A lists these requirements and includes a description of ACE requirements met and those requirements that are not met for each section of this document. The Purple Computing Environment, along with the ACE mappings, has been issued and reviewed throughout the Tri-lab community.

  9. 25 CFR 36.85 - Is a nurse required to be available in the evenings?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Is a nurse required to be available in the evenings? 36... SITUATIONS Homeliving Programs Staffing § 36.85 Is a nurse required to be available in the evenings? No, a program is not required to make a nurse (LPN or RN) available in the evenings. However, this is...

  10. A lightweight high availability strategy for Atlas LCG File Catalogs

    Energy Technology Data Exchange (ETDEWEB)

    Martelli, Barbara; Salvo, Alessandro de; Anzellotti, Daniela; Rinaldi, Lorenzo; Cavalli, Alessandro; Pra, Stefano dal; Dell' Agnello, Luca; Gregori, Daniele; Prosperini, Andrea; Ricci, Pier Paolo; Sapunenko, Vladimir, E-mail: barbara.martelli@cnaf.infn.i [Viale Berti Pichat 6/2, Bologna I-40127 (Italy)

    2010-04-01

    The LCG File Catalog is a key component of the LHC Computing Grid middleware [1], as it contains the mapping between Logical File Names and Physical File Names on the Grid. The Atlas computing model foresees multiple local LFC housed in each Tier-1 and Tier-0, containing all information about files stored in the regional cloud. As the local LFC contents are presently not replicated anywhere, this turns out in a dangerous single point of failure for all of the Atlas regional clouds. In order to solve this problem we propose a novel solution for high availability (HA) of Oracle based Grid services, obtained by composing an Oracle Data Guard deployment and a series of application level scripts. This approach has the advantage of being very easy to deploy and maintain, and represents a good candidate solution for all Tier-2s which are usually little centres with little manpower dedicated to service operations. We also present the results of a wide range of functionality and performance tests run on a test-bed having characteristics similar to the ones required for production. The test-bed consists of a failover deployment between the Italian LHC Tier-1 (INFN - CNAF) and an Atlas Tier-2 located at INFN - Roma1. Moreover, we explain how the proposed strategy can be deployed on the present Grid infrastructure, without requiring any change to the middleware and in a way that is totally transparent to end users and applications.

  11. A lightweight high availability strategy for Atlas LCG File Catalogs

    Science.gov (United States)

    Martelli, Barbara; de Salvo, Alessandro; Anzellotti, Daniela; Rinaldi, Lorenzo; Cavalli, Alessandro; dal Pra, Stefano; dell'Agnello, Luca; Gregori, Daniele; Prosperini, Andrea; Ricci, Pier Paolo; Sapunenko, Vladimir

    2010-04-01

    The LCG File Catalog is a key component of the LHC Computing Grid middleware [1], as it contains the mapping between Logical File Names and Physical File Names on the Grid. The Atlas computing model foresees multiple local LFC housed in each Tier-1 and Tier-0, containing all information about files stored in the regional cloud. As the local LFC contents are presently not replicated anywhere, this turns out in a dangerous single point of failure for all of the Atlas regional clouds. In order to solve this problem we propose a novel solution for high availability (HA) of Oracle based Grid services, obtained by composing an Oracle Data Guard deployment and a series of application level scripts. This approach has the advantage of being very easy to deploy and maintain, and represents a good candidate solution for all Tier-2s which are usually little centres with little manpower dedicated to service operations. We also present the results of a wide range of functionality and performance tests run on a test-bed having characteristics similar to the ones required for production. The test-bed consists of a failover deployment between the Italian LHC Tier-1 (INFN - CNAF) and an Atlas Tier-2 located at INFN - Roma1. Moreover, we explain how the proposed strategy can be deployed on the present Grid infrastructure, without requiring any change to the middleware and in a way that is totally transparent to end users and applications.

  12. Design and reliability, availability, maintainability, and safety analysis of a high availability quadruple vital computer system

    Institute of Scientific and Technical Information of China (English)

    Ping TAN; Wei-ting HE; Jia LIN; Hong-ming ZHAO; Jian CHU

    2011-01-01

    With the development of high-speed railways in China,more than 2000 high-speed trains will be put into use.Safety and efficiency of railway transportation is increasingly important.We have designed a high availability quadruple vital computer (HAQVC) system based on the analysis of the architecture of the traditional double 2-out-of-2 system and 2-out-of-3 system.The HAQVC system is a system with high availability and safety,with prominent characteristics such as fire-new internal architecture,high efficiency,reliable data interaction mechanism,and operation state change mechanism.The hardware of the vital CPU is based on ARM7 with the real-time embedded safe operation system (ES-OS).The Markov modeling method is designed to evaluate the reliability,availability,maintainability,and safety (RAMS) of the system.In this paper,we demonstrate that the HAQVC system is more reliable than the all voting triple modular redundancy (AVTMR) system and double 2-out-of-2 system.Thus,the design can be used for a specific application system,such as an airplane or high-speed railway system.

  13. Highly Available DHTs: Keeping Data Consistency After Updates

    NARCIS (Netherlands)

    Knežević, P.; Wombacher, Andreas; Risse, T.

    2006-01-01

    The research in the paper is motivated by building a decentralized/P2P XML storage on top of a DHT (Distributed Hash Table). The storage must provide high data availability and support updates. High data availability in a DHT can be guaranteed by data replication. However, DHTs can not provide a

  14. High plant availability of phosphorus and low availability of cadmium in four biomass combustion ashes

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xiaoxi, E-mail: Xiaoxi.Li@agro.au.dk; Rubæk, Gitte H.; Sørensen, Peter

    2016-07-01

    For biomass combustion to become a sustainable energy production system, it is crucial to minimise landfill of biomass ashes, to recycle the nutrients and to minimise the undesirable impact of hazardous substances in the ash. In order to test the plant availability of phosphorus (P) and cadmium (Cd) in four biomass ashes, we conducted two pot experiments on a P-depleted soil and one mini-plot field experiment on a soil with adequate P status. Test plants were spring barley and Italian ryegrass. Ash applications were compared to triple superphosphate (TSP) and a control without P application. Both TSP and ash significantly increased crop yields and P uptake on the P-depleted soil. In contrast, on the adequate-P soil, the barley yield showed little response to soil amendment, even at 300–500 kg P ha{sup −1} application, although the barley took up more P at higher applications. The apparent P use efficiency of the additive was 20% in ryegrass - much higher than that of barley for which P use efficiencies varied on the two soils. Generally, crop Cd concentrations were little affected by the increasing and high applications of ash, except for relatively high Cd concentrations in barley after applying 25 Mg ha{sup −1} straw ash. Contrarily, even modest increases in the TSP application markedly increased Cd uptake in plants. This might be explained by the low Cd solubility in the ash or by the reduced Cd availability due to the liming effect of ash. High concentrations of resin-extractable P (available P) in the ash-amended soil after harvest indicate that the ash may also contribute to P availability for the following crops. In conclusion, the biomass ashes in this study had P availability similar to the TSP fertiliser and did not contaminate the crop with Cd during the first year. - Highlights: • Effects of four biomass ashes vs. a P fertiliser (TSP) on two crops were studied. • Ashes increased crop yields with P availability similar to TSP on P-depleted soil

  15. 75 FR 62515 - Notice of Availability of Report on the Communications Requirements of Smart Grid Technologies

    Science.gov (United States)

    2010-10-12

    ... of Availability of Report on the Communications Requirements of Smart Grid Technologies AGENCY..., ``Communications Requirements of Smart Grid Technologies.'' In this report, DOE sets forth recommendations and observations on current and potential communications requirements of the Smart Grid, as well as the types of...

  16. High plant availability of phosphorus and low availability of cadmium in four biomass combustion ashes

    DEFF Research Database (Denmark)

    Li, Xiaoxi; Rubæk, Gitte Holton; Sørensen, Peter

    2016-01-01

    For biomass combustion to become a sustainable energy production system, it is crucial to minimise landfill of biomass ashes, to recycle the nutrients and to minimise the undesirable impact of hazardous substances in the ash. In order to test the plant availability of phosphorus (P) and cadmium (Cd......) in four biomass ashes, we conducted two pot experiments on a P-depleted soil and one mini-plot field experiment on a soil with adequate P status. Test plants were spring barley and Italian ryegrass. Ash applications were compared to triple superphosphate (TSP) and a control without P application. Both TSP...... ash. Contrarily, even modest increases in the TSP application markedly increased Cd uptake in plants. This might be explained by the low Cd solubility in the ash or by the reduced Cd availability due to the liming effect of ash. High concentrations of resin-extractable P (available P) in the ash...

  17. Examining the antecedents of challenge and threat states: the influence of perceived required effort and support availability.

    Science.gov (United States)

    Moore, Lee J; Vine, Samuel J; Wilson, Mark R; Freeman, Paul

    2014-08-01

    To date, limited research has explicitly examined the antecedents of challenge and threat states proposed by the biopsychosocial model. Thus, the aim of the present study was to examine the influence of perceived required effort and support availability on demand/resource evaluations, challenge and threat states, and motor performance. A 2 (required effort; high, low)×2 (support availability; available, not available) between-subjects design was used with one hundred and twenty participants randomly assigned to one of four experimental conditions. Participants received instructions designed to manipulate perceptions of required effort and support availability before demand/resource evaluations and cardiovascular responses were assessed. Participants then performed the novel motor task (laparoscopic surgery) while performance was recorded. Participants in the low perceived required effort condition evaluated the task as more of a challenge (i.e., resources outweighed demands), exhibited a cardiovascular response more indicative of a challenge state (i.e., higher cardiac output and lower total peripheral resistance), and performed the task better (i.e., quicker completion time) than those in the high perceived required effort condition. However, perceptions of support availability had no significant impact on participants' demand/resource evaluations, cardiovascular responses, or performance. Furthermore, there was no significant interaction effect between perceptions of required effort and support availability. The findings suggest that interventions aimed at promoting a challenge state should include instructions that help individuals perceive that the task is not difficult and requires little physical and mental effort to perform effectively.

  18. 20 CFR 604.3 - Able and available requirement-general principles.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Able and available requirement-general principles. 604.3 Section 604.3 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF...—general principles. (a) A State may pay UC only to an individual who is able to work and available...

  19. High Availability Solution: Resource Usage Management in Virtualized Software Aging

    Directory of Open Access Journals (Sweden)

    Aye Myat Myat Paing

    2012-07-01

    Full Text Available As businesses increasingly rely on IT for their mission-critical operations, continuous availability is auniversal concern. Nowadays, virtualized platform has become the popular option to deploy complexenough services. Deployed services are expected to be always, available, but these long running servicesare especially sensitive to suffer from software aging phenomenon. Software aging of virtual machinemonitors (VMMs is becoming critical because performance degradation or crash failure of a VMM affectsall virtual machines (VMs on it. To counteract this issue, we deploy software rejuvenation methodology.To eliminate the service outage during software rejuvenation process, we combine the rejuvenation withlive migration technology. Live VM migration enables a running VM on a host serer to move onto the otherhost server with very small interruption of the execution. Live VM migration depends on VMs placementand efficient resource available is required. The idea behind our paper is two-fold. First, we present theoptimization of the resource usage as accepting as many services as in virtualized environment whichsupport of VM live migration. Second, to demonstrate how much it can improve system availability, thestochastic Petri nets model a virtualized server system in case of using time based software rejuvenation forVMM is presented. Finally, we perform the numerical analysis to evaluate the model.

  20. Approach to Achieve High Availability in Critical Infrastructure

    Science.gov (United States)

    2015-09-01

    Regardless, current technology includes RFID tags for systems, and tablets can be implemented to assist in real-time updates. Current Wi-Fi technology can...APPROACH TO ACHIEVE HIGH AVAILABILITY IN CRITICAL INFRASTRUCTURE Yew Kee Hoo Senior Engineer, Defence Science and Technology Agency, Singapore B.E...Between Failure MTTF Mean Time to Repair NAVFAC Naval Facilities Engineering Command xvi O&M Operations and Maintenance RFID Radio Frequency

  1. Available phosphorus requirement of sex-reversed red tilapia fed all-plant diets

    Directory of Open Access Journals (Sweden)

    Udomnan Udom

    2008-01-01

    Full Text Available A feeding trial was conducted to estimate the optimum requirement of dietary phoshporus (P for sex-reversed red tilapia in glass aquaria (50x100x47cm. Six practical diets were formulated to contain graded levels (0.58, 0.66, 0.72, 0.75 and 0.82% of available P from all-plant raw ingredients and dicalcium phosphate (DCP. Each diet was randomly assigned to triplicate groups of fish, and each group was stocked with 20 fish (initial body weight, 25.16g 0.13. Fish were fed twice daily (08:00 and 16:00 ad libitum for 8 weeks. Average body weight and weight gain significantly increased with increasing available P (P<0.05. The whole body composition analysis showed that lipid and protein as well as P contents in whole body, vertebrae ash and vertebrae p, were significantly affected by available P (P<0.05. The blood biochemistry analysis showed that serum P and serum alkaline phosphatase activity increased with the increase of dietary available P levels (P<0.05. Data for weight gain, FCR, whole body P, vertebrae ash, vertebrae P, muscle protein, muscle fat and visceral fat were subjected to regression analysis to determine effects of the dietary levels of available P on these responses. Employing quadratic non-linear regression model of the relationship between available dietary P and P in vertebrae and whole body to study the P requirement, it was found that available dietary P requirement for sex-reversed red tilapia from the current study were of 0.76 and 0.79%, respectively. Increasing the dietary available P to higher concentration appears to reduce muscle fat while muscle protein increases.

  2. Condom availability in high risk places and condom use

    DEFF Research Database (Denmark)

    Sandøy, Ingvild Fossgard; Blystad, Astrid; Shayo, Elizabeth H.;

    2012-01-01

    and one in Zambia. The study was based on a triangulation of data collection methods in the three study districts: surveys in venues where people meet new sexual partners, population-based surveys and focus group discussions. The data was collected within an overall study on priority setting in health......Background A number of studies from countries with severe HIV epidemics have found gaps in condom availability, even in places where there is a substantial potential for HIV transmission. Although reported condom use has increased in many African countries, there are often big differences...... by socioeconomic background. The aim of this study was to assess equity aspects of condom availability and uptake in three African districts to evaluate whether condom programmes are given sufficient priority. Methods Data on condom availability and use was examined in one district in Kenya, one in Tanzania...

  3. Biomedical Requirements for High Productivity Computing Systems

    Science.gov (United States)

    2005-04-01

    operations performed by embedded C ++ libraries. While Python is not currently used directly for numerically intensive work it would be quite desirable if...performed by embedded C ++ libraries. The availability of a higher performance python solution is highly desirable, i.e. – a python compiler or better JIT...be desirable. - Virtually all high-level programming is now done in Python with numerically intensive operations performed by embedded C ++ libraries

  4. Confidentiality, Integrity and High Availability with Open Source IT green

    CERN Document Server

    Guimaraes, Luciana

    2008-01-01

    This paper presents elements that form the structure of a network of data using secure stable and mature technologies that meet the requirement of having code free. The principle would be conflicting code open Tuesday where he wants to keep maximum control over the data but is already evidence that open source does not hide the famous backdoor possible in closed systems code. Basearemos this work experience gained in a real environment and using paravirtualization to show a situation more critical and now real in most companies, the virtualization of servers.

  5. Architecture & Design of Affordable and Highly Available Enterprise Cloud Service

    Directory of Open Access Journals (Sweden)

    Rabi Prasad Padhy

    2013-01-01

    Full Text Available Cloud computing is a way to increase capacity or add capabilities on the fly without investing in additional infrastructure, licensing additional software or training new personnel. Enterprises must embrace this bleeding edge real-time business model in order to compete in the current marketplace. Deployment of enterprise applications in public cloud can reduce investment on IT infrastructure both in terms of hardware and software, whenever new services are to be provisioned. Furthermore, cloud services are quite attractive to business because of its dynamic scalability, privacy, performance and ability to handle heterogeneous environments. Instead of spending a lot of time in figuring out server setup and working on routers, it is judicious to subscribe cloud based 24/7 support and affordable services. It’s an extremely important consideration to subscribe to at least two cloud vendors for smooth running of applications and ensure application availability by switching from one provider to another with minimal management effort. In this article we have proposed an architecture and design of a cost affordable online enterprise cloud application that subscribes to two public cloud vendors with respect to cost and availability parameters. We also present the reasons for the current trend of enterprises moving towards 24/7 online business cloud services.

  6. High available and fault tolerant mobile communications infrastructure

    DEFF Research Database (Denmark)

    Beiroumi, Mohammad Zib

    2006-01-01

    as it is the case for many recovery techniques. In addition, the method does not require any modification to mobile clients. The Communicating Extended Finite State Machine (CEFSM) is used to model the behavior of the infrastructure applications. The model based recovery scheme is integrated in the application...... using rollback or replication techniques inapplicable. This dissertation presents a novel failure recovery approach based on a behavioral model of the communication protocols. The new recovery method is able to deal with software and hardware faults and is particularly suitable for mobile communications...... infrastructure. The method enables the faulty applications in the infrastructure to quickly and effectively resume their services to their mobile clients with no or minimal loss of work after failure. In our approach, we do not assume a specific fault behavior for example failstop or transient behavior...

  7. Does High Educational Attainment Limit the Availability of Romantic Partners?

    Science.gov (United States)

    Burt, Isaac; Lewis, Sally V.; Beverly, Monifa G.; Patel, Samir H.

    2010-01-01

    Research indicates that highly educated individuals endure hardships in finding suitable romantic partners. Romantic hardships affect social and emotional adjustment levels, leading to low self-efficacy in relationship decision making. To address the need for research pertaining to this topic, the authors explored the experiences of eight…

  8. Constellation Ground Systems Launch Availability Analysis: Enhancing Highly Reliable Launch Systems Design

    Science.gov (United States)

    Gernand, Jeffrey L.; Gillespie, Amanda M.; Monaghan, Mark W.; Cummings, Nicholas H.

    2010-01-01

    Success of the Constellation Program's lunar architecture requires successfully launching two vehicles, Ares I/Orion and Ares V/Altair, in a very limited time period. The reliability and maintainability of flight vehicles and ground systems must deliver a high probability of successfully launching the second vehicle in order to avoid wasting the on-orbit asset launched by the first vehicle. The Ground Operations Project determined which ground subsystems had the potential to affect the probability of the second launch and allocated quantitative availability requirements to these subsystems. The Ground Operations Project also developed a methodology to estimate subsystem reliability, availability and maintainability to ensure that ground subsystems complied with allocated launch availability and maintainability requirements. The verification analysis developed quantitative estimates of subsystem availability based on design documentation; testing results, and other information. Where appropriate, actual performance history was used for legacy subsystems or comparative components that will support Constellation. The results of the verification analysis will be used to verify compliance with requirements and to highlight design or performance shortcomings for further decision-making. This case study will discuss the subsystem requirements allocation process, describe the ground systems methodology for completing quantitative reliability, availability and maintainability analysis, and present findings and observation based on analysis leading to the Ground Systems Preliminary Design Review milestone.

  9. Exigência de fósforo disponível para suínos machos castrados selecionados para deposição de carne magra, dos 30 aos 60kg Available phosphorus requirement of barrows from 30 to 60kg selected for high lean deposition

    Directory of Open Access Journals (Sweden)

    C.L.C. Arouca

    2009-10-01

    phosphorus. There was a linear effect of available phosphorus level on daily phosphorus intake, alkaline phosphatase on the 21st day and alkaline phosphatase at the end of the experiment. Dietary available phosphorus requirement for 30 to 60kg high lean barrows was 0.39%, which corresponds to an available phosphorus intake of 9.11g/day.

  10. Condom availability in high risk places and condom use

    DEFF Research Database (Denmark)

    Sandøy, Ingvild Fossgard; Blystad, Astrid; Shayo, Elizabeth H.

    2012-01-01

    study findings indicate that substantial further efforts should be made to secure that condoms are easily accessible in places where sexual relationships are initiated. Although condom distribution in drinking places has been pinpointed in the HIV/AIDS prevention strategies of all the three countries......Background A number of studies from countries with severe HIV epidemics have found gaps in condom availability, even in places where there is a substantial potential for HIV transmission. Although reported condom use has increased in many African countries, there are often big differences...... and one in Zambia. The study was based on a triangulation of data collection methods in the three study districts: surveys in venues where people meet new sexual partners, population-based surveys and focus group discussions. The data was collected within an overall study on priority setting in health...

  11. 76 FR 49772 - Guidance for Industry: Bar Code Label Requirements-Questions and Answers; Availability

    Science.gov (United States)

    2011-08-11

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Bar Code Label Requirements... Industry: Bar Code Label Requirements--Questions and Answers'' dated August 2011. The guidance announced in... finalizes the draft guidance entitled ``Guidance for Industry: Bar Code Label Requirements--Questions and...

  12. High availability through full redundancy of the CMS detector controls system

    CERN Document Server

    Bauer, Gerry; Bouffet, Olivier; Bowen, Matthew; Branson, James G; Bukowiec, Sebastian; Ciganek, Marek; Cittolin, Sergio; Jose Antonio Coarasa; Deldicque, Christian; Dobson, Marc; Dupont, Aymeric; Erhan, Samim; Flossdorf, Alexander; Gigi, Dominique; Glege, Frank; Gomez-Reino, Robert; Hartl, Christian; Hegeman, Jeroen; Holzner, André; Yi Ling Hwong; Masetti, Lorenzo; Meijers, Frans; Meschi, Emilio; Mommsen, Remigius K; O'Dell, Vivian; Orsini, Luciano; Paus, Christoph; Petrucci, Andrea; Pieri, Marco; Polese, Giovanni; Racz, Attila; Raginel, Olivier; Sakulin, Hannes; Sani, Matteo; Schwick, Christoph; Shpakov, Dennis; Simon, Michal; Andrei Cristian Spataru; Sumorok, Konstanty

    2012-01-01

    The CMS detector control system (DCS) is responsible for controlling and monitoring the detector status and for the operation of all CMS sub detectors and infrastructure. This is required to ensure safe and efficient data taking so that high quality physics data can be recorded. The current system architecture is composed of more than 100 servers in order to provide the required processing resources. An optimization of the system software and hardware architecture is under development to ensure redundancy of all the controlled sub-systems and to reduce any downtime due to hardware or software failures. The new optimized structure is based mainly on powerful and highly reliable blade servers and makes use of a fully redundant approach, guaranteeing high availability and reliability. The analysis of the requirements, the challenges, the improvements and the optimized system architecture as well as its specific hardware and software solutions are presented.

  13. 40 CFR 125.94 - How will requirements reflecting best technology available for minimizing adverse environmental...

    Science.gov (United States)

    2010-07-01

    ... technology available for minimizing adverse environmental impact be established for my Phase II existing... technology available to minimize adverse environmental impact for your facility in accordance with paragraphs... technology available for minimizing adverse environmental impact. This determination must be based...

  14. High-power LED package requirements

    Science.gov (United States)

    Wall, Frank; Martin, Paul S.; Harbers, Gerard

    2004-01-01

    Power LEDs have evolved from simple indicators into illumination devices. For general lighting applications, where the objective is to light up an area, white LED arrays have been utilized to serve that function. Cost constraints will soon drive the industry to provide a discrete lighting solution. Early on, that will mean increasing the power densities while quantum efficiencies are addressed. For applications such as automotive headlamps & projection, where light needs to be tightly collimated, or controlled, arrays of die or LEDs will not be able to satisfy the requirements & limitations defined by etendue. Ultimately, whether a luminaire requires a small source with high luminance, or light spread over a general area, economics will force the evolution of the illumination LED into a compact discrete high power package. How the customer interfaces with this new package should be an important element considered early on in the design cycle. If an LED footprint of adequate size is not provided, it may prove impossible for the customer, or end user, to get rid of the heat in a manner sufficient to prevent premature LED light output degradation. Therefore it is critical, for maintaining expected LED lifetime & light output, that thermal performance parameters be defined, by design, at the system level, which includes heat sinking methods & interface materials or methdology.

  15. 12 CFR 339.3 - Requirement to purchase flood insurance where available.

    Science.gov (United States)

    2010-01-01

    ... STATEMENTS OF GENERAL POLICY LOANS IN AREAS HAVING SPECIAL FLOOD HAZARDS § 339.3 Requirement to purchase... broker or other entity through table funding shall be considered to be making a loan for the purposes...

  16. Germination requirements and seedling responses to water availability and soil type in four eucalypt species

    Science.gov (United States)

    Schütz, Wolfgang; Milberg, Per; Lamont, Byron B.

    2002-03-01

    We conducted experiments on seed germination, seedling survival and seedling growth of four Eucalyptus species to identify factors that might explain why they are restricted to the two major soil types in southwestern Australia, deep sands ( E. macrocarpa, E. tetragona) and lateritic loam ( E. loxophleba, E. wandoo). At high temperatures (28 °C), germination in darkness was lower for the two 'loam species' than for the 'sand species', while there were no differences in light or at low temperatures (10 °C). Germination commenced earlier, and was faster in the sand species than in the loam species, but was almost inhibited in all species by -1.0 MPa. E. tetragona proved the most drought-tolerant in terms of germination level and seedling survival. Seedlings of the sand species had much longer roots two weeks after germination in the absence of water stress, and the roots of more seedlings continued to elongate under moderate water stress (-1.0 MPa), than the two loam species. Roots were longer in all species, except E. macrocarpa, at -0.5 MPa than at -0.1 MPa, despite seedlings having a smaller mass and hypocotyl length. As water availability declined, there was a tendency for the sand species to survive longer on sand than on loam while soil type had no effect on the loam species. Pattern and duration of seedling survival of the loam species was similar to that of the sand species despite their smaller seeds. We conclude that seedlings from the large-seeded sand species are able to penetrate the soil profile faster and deeper, but that they are not less prone to drying soils than seedlings from the small-seeded loam species. Instead, seed size and germination speed are important prerequisites to cope successfully with unstable soil surfaces and to exploit the rapidly descending water in deep sands.

  17. 25 CFR 1000.42 - Will grants always be made available to meet the planning phase requirement as described in...

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Will grants always be made available to meet the planning... 402(d) Planning and Negotiation Grants Availability, Amount, and Number of Grants § 1000.42 Will grants always be made available to meet the planning phase requirement as described in section 402(d)...

  18. Superficial Water Resource at Tempisque River Watershed, Costa Rica: Availability and Requirement Perspective

    Directory of Open Access Journals (Sweden)

    Isabel Guzmán-Arias

    2014-03-01

    Full Text Available This paper describes the status of water resources availability and demand in the upper and middle Tempisque watershed projected up to 2030 and the proposed actions to start a planning process. The resource availability scenarios incorporate the modifications inwater flows due to land use and cli­mate changes; these combined effects increases the problems of water shortages during the dry season. The resource demand scenarios include projections provided by the major users in the watershed, of which very few can envision growth expectations in terms of water consumption. The proposed resource planning process integrates the analysis conducted in this thesis and tries to identify the basic steps to be followed for the pro­per management of the resource in the future.

  19. Building highly available control system applications with Advanced Telecom Computing Architecture and open standards

    Science.gov (United States)

    Kazakov, Artem; Furukawa, Kazuro

    2010-11-01

    Requirements for modern and future control systems for large projects like International Linear Collider demand high availability for control system components. Recently telecom industry came up with a great open hardware specification - Advanced Telecom Computing Architecture (ATCA). This specification is aimed for better reliability, availability and serviceability. Since its first market appearance in 2004, ATCA platform has shown tremendous growth and proved to be stable and well represented by a number of vendors. ATCA is an industry standard for highly available systems. On the other hand Service Availability Forum, a consortium of leading communications and computing companies, describes interaction between hardware and software. SAF defines a set of specifications such as Hardware Platform Interface, Application Interface Specification. SAF specifications provide extensive description of highly available systems, services and their interfaces. Originally aimed for telecom applications, these specifications can be used for accelerator controls software as well. This study describes benefits of using these specifications and their possible adoption to accelerator control systems. It is demonstrated how EPICS Redundant IOC was extended using Hardware Platform Interface specification, which made it possible to utilize benefits of the ATCA platform.

  20. Patient care and nursing practice when staff requirements exceed staff availability.

    Science.gov (United States)

    Maloney, J P; Allanach, B C; Bartz, C; Peterson, S L

    1993-08-01

    This study examined the Workload Management System for Nurses at a tertiary-care Army hospital to determine the incongruence between recommended nursing care hours and actual nursing care hours provided. The purpose of the study was to describe patient care and nursing practice when calculated staff requirements exceed actual staff availabilty. The findings of the study indicated that basic nursing care tasks were accomplished; however, professional development activities were sacrificed. The data reveal that nurses do not have the time to grow professionally through research or education, and they are reduced to assembly-line mentality as they go from task to task without being able to care for a patient as a person.

  1. Unmanned Carrier-based Aircraft System: Navy Needs to Demonstrate Match between Its Requirements and Available Resources

    Science.gov (United States)

    2015-05-01

    UNMANNED CARRIER -BASED AIRCRAFT SYSTEM Navy Needs to Demonstrate Match between Its Requirements and Available...DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Unmanned Carrier -based Aircraft System: Navy Needs to Demonstrate Match between Its...UNMANNED CARRIER -BASED AIRCRAFT SYSTEM Navy Needs to Demonstrate Match between Its Requirements and Available Resources Why GAO Did This Study The

  2. Krait bite requiring high dose antivenom: a case report.

    Science.gov (United States)

    Sharma, Sanjib Kumar; Koirala, Shekhar; Dahal, Gaheraj

    2002-03-01

    Anti snake venom (ASV) is the most specific therapy available for treatment of snakebite envenomation. The ASV available in Nepal are polyvalent ASV produced in India and are effective against envenomation by cobra and krait, the two most common species found in Eastern Nepal. Neurotoxic signs respond slowly and unconvincingly and continuous absorption of venom may cause recurrent neurotoxicity. Therefore, close observation and continuous administration of ASV is essential to save the victim. We report a case of neurotoxic envenomation due to bite by common krait (Bangarus caeruleus). The victim required very high dose of polyvalent ASV for reversal of neurological manifestations.

  3. Availability and cost estimate of a high naphthene, modified aviation turbine fuel

    Science.gov (United States)

    Prok, George M.

    1988-01-01

    Information from an Air Force study was used to determine the potential availability and cost of a modified conventional fuel with a naphthene content which could have a thermal stability near that of JP-7 for high-speed civil transports. Results showed sufficient capacity for a fuel made of a blend of 50 percent naphthenic straight run kerosene and 50 percent hydrocracked product, assuming a near-term requirement of 210,000 BBL per day. Fuel cost would be as low as 62.5 to 64.5 cents per gallon, assuming 20 dollars per barrel for crude.

  4. Nutritional and fluid requirements: high-output stomas.

    Science.gov (United States)

    Medlin, Sophie

    Based on the current available evidence, this article explores the nutritional management of those with a high-output stoma. The main alterations required to the intake of patients with a high-output stoma include the use of an oral rehydration solution to ensure optimum absorption of fluid and sodium, and a high-calorie, high-protein diet, with the aim of optimizing nutritional status. Diet advice should be delivered by a dietitian with experience in managing these complex patients. Monitoring of electrolytes and micronutrients is essential, and long-term follow up from a multidisciplinary nutrition support team is invaluable in coordinating this. Patients with high-output stomas can enjoy good quality of life and long-term health if their condition is managed effectively by a well-organized multidisciplinary team.

  5. Requirements for very high energy accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Richter, B.

    1985-04-01

    In this introductory paper at the second Workshop on Laser Acceleration my main goal is to set what I believe to be the energy and luminosity requirements of the machines of the future. These specifications are independent of the technique of accelerations. But, before getting to these technical questions, I will briefly review where we are in particle physics, for it is the large number of unanswered questions in physics that motivates the search for effective accelerators.

  6. Availability of high-magnitude streamflow for groundwater banking in the Central Valley, California

    Science.gov (United States)

    Kocis, Tiffany N.; Dahlke, Helen E.

    2017-08-01

    California’s climate is characterized by the largest precipitation and streamflow variability observed within the conterminous US This, combined with chronic groundwater overdraft of 0.6-3.5 km3 yr-1, creates the need to identify additional surface water sources available for groundwater recharge using methods such as agricultural groundwater banking, aquifer storage and recovery, and spreading basins. High-magnitude streamflow, i.e. flow above the 90th percentile, that exceeds environmental flow requirements and current surface water allocations under California water rights, could be a viable source of surface water for groundwater banking. Here, we present a comprehensive analysis of the magnitude, frequency, duration and timing of high-magnitude streamflow (HMF) for 93 stream gauges covering the Sacramento, San Joaquin and Tulare basins in California. The results show that in an average year with HMF approximately 3.2 km3 of high-magnitude flow is exported from the entire Central Valley to the Sacramento-San Joaquin Delta often at times when environmental flow requirements of the Delta and major rivers are exceeded. High-magnitude flow occurs, on average, during 7 and 4.7 out of 10 years in the Sacramento River and the San Joaquin-Tulare Basins, respectively, from just a few storm events (5-7 1-day peak events) lasting for 25-30 days between November and April. The results suggest that there is sufficient unmanaged surface water physically available to mitigate long-term groundwater overdraft in the Central Valley.

  7. 77 FR 53870 - Availability of a Legal Entity Identifier Meeting the Requirements of the Regulations of the...

    Science.gov (United States)

    2012-09-04

    ... in recordkeeping and swap data reporting. Section 45.6(f)(1) provides that: When a legal entity... COMMISSION Availability of a Legal Entity Identifier Meeting the Requirements of the Regulations of the Commodity Futures Trading Commission and Designation of Provider of Legal Entity Identifiers To Be Used...

  8. 76 FR 57690 - TRICARE; Elimination of the Non-Availability Statement (NAS) Requirement for Non-Emergency...

    Science.gov (United States)

    2011-09-16

    ... of the Secretary 32 CFR Part 199 RIN 0720-AB52 TRICARE; Elimination of the Non-Availability Statement (NAS) Requirement for Non-Emergency Inpatient Mental Health Care AGENCY: Office of the Secretary... states a NAS is needed for non-emergency inpatient mental health care in order for a TRICARE Standard...

  9. Evaluation of reliability, availability, maintainability and safety requirements for manned space vehicles with extended on-orbit stay time

    Science.gov (United States)

    Carlier, S.; Coindoz, M.; Deneuville, L.; Garbellini, L.; Altavilla, A.

    1996-01-01

    The recent manned space transportation vehicles studies performed by ESA and European Industry, investigate the possibility of extended on-orbit stay time. From the RAMS (Reliability, Availability, Maintainability, Safety) point of view, these vehicles will have to meet, in addition to the multi-phase mission safety and reliability constraints, stringent on-orbit availability levels which will be among the most important design and operations drivers. The objective of the paper is to derive the lessons learnt from the Assured Crew Return Vehicle (ACRV) feasibility phase study, in terms of RAMS requirements specification. The paper briefly assesses the deterministic RAMS requirements derived from ESA and NASA applicable standards and focuses on the probabilistic requirements which were the subject of numerous interpretations. Different approaches are presented together with their impacts on the design (maintainability, testability, on-orbit replaceable units concept,…) and on the operations (check-out frequency, logistics,…). The main uncertainties are also assessed. In conclusion, recommendations are made for the specification of RAMS requirements for manned space vehicles with extended on-orbit stay time.

  10. Development of high-availability ATCA/PCIe data acquisition instrumentation

    Energy Technology Data Exchange (ETDEWEB)

    Correia, Miguel; Sousa, Jorge; Batista, Antonio J.N.; Combo, Alvaro; Santos, Bruno; Rodrigues, Antonio P.; Carvalho, Paulo F.; Goncalves, Bruno [Instituto de Plasmas e Fusao Nuclear, Instituto Superior Tecnico, Universidade de Lisboa, 1049- 001 Lisboa (Portugal); Correia, Carlos M.B.A. [Centro de Instrumentacao, Dept. de Fisica, Universidade de Coimbra, 3004-516 Coimbra (Portugal)

    2015-07-01

    Latest Fusion energy experiments envision a quasi-continuous operation regime. In consequence, the largest experimental devices, currently in development, specify high-availability (HA) requirements for the whole plant infrastructure. HA features enable the whole facility to perform seamlessly in the case of failure of any of its components, coping with the increasing duration of plasma discharges (steady-state) and assuring safety of equipment, people, environment and investment. IPFN developed a control and data acquisition system, aiming for fast control of advanced Fusion devices, which is thus required to provide such HA features. The system is based on in-house developed Advanced Telecommunication Computing Architecture (ATCA) instrumentation modules - IO blades and data switch blades, establishing a PCIe network on the ATCA shelf's back-plane. The data switch communicates to an external host computer through a PCIe data network. At the hardware management level, the system architecture takes advantage of ATCA native redundancy and hot swap specifications to implement fail-over substitution of IO or data switch blades. A redundant host scheme is also supported by the ATCA/PCIe platform. At the software level, PCIe provides implementation of hot plug services, which translate the hardware changes to the corresponding software/operating system devices. The paper presents how the ATCA and PCIe based system can be setup to perform with the desired degree of HA, thus being suitable for advanced Fusion control and data acquisition systems. (authors)

  11. A software and hardware architecture for a high-availability PACS.

    Science.gov (United States)

    Gutiérrez-Martínez, Josefina; Núñez-Gaona, Marco Antonio; Aguirre-Meneses, Heriberto; Delgado-Esquerra, Ruth Evelin

    2012-08-01

    Increasing radiology studies has led to the emergence of new requirements for management medical information, mainly affecting the storage of digital images. Today, it is a necessary interaction between workflow management and legal rules that govern it, to allow an efficient control of medical technology and associated costs. Another important topic that is growing in importance within the healthcare sector is compliance, which includes the retention of studies, information security, and patient privacy. Previously, we conducted a series of extensive analysis and measurements of pre-existing operating conditions. These studies and projects have been described in other papers. The first phase: hardware and software installation and initial tests were completed in March 2006. The storage phase was built step by step until the PACS-INR was totally completed. Two important aspects were considered in the integration of components: (1) the reliability and performance of the system to transfer and display DICOM images, and (2) the availability of data backups for disaster recovery and downtime scenarios. This paper describes the high-availability model for a large-scale PACS to support the storage and retrieve of data using CAS and DAS technologies to provide an open storage platform. This solution offers a simple framework that integrates and automates the information at low cost and minimum risk. Likewise, the model allows an optimized use of the information infrastructure in the clinical environment. The tests of the model include massive data migration, openness, scalability, and standard compatibility to avoid locking data into a proprietary technology.

  12. An Analysis of Illinois High School Graduation Requirements.

    Science.gov (United States)

    Ferratier, Louis; Helmich, Edith

    On account of concern about declining achievement levels of high school graduates and proposed state legislation increasing graduation requirements to address this concern, this report analyzes current and proposed high school graduation requirements in Illinois, based on data compiled from local school documents, and compares the data to…

  13. Estimating shallow groundwater availability in small catchments using streamflow recession and instream flow requirements of rivers in South Africa

    Science.gov (United States)

    Ebrahim, Girma Y.; Villholth, Karen G.

    2016-10-01

    Groundwater is an important resource for multiple uses in South Africa. Hence, setting limits to its sustainable abstraction while assuring basic human needs is required. Due to prevalent data scarcity related to groundwater replenishment, which is the traditional basis for estimating groundwater availability, the present article presents a novel method for determining allocatable groundwater in quaternary (fourth-order) catchments through information on streamflow. Using established methodologies for assessing baseflow, recession flow, and instream ecological flow requirement, the methodology develops a combined stepwise methodology to determine annual available groundwater storage volume using linear reservoir theory, essentially linking low flows proportionally to upstream groundwater storages. The approach was trialled for twenty-one perennial and relatively undisturbed catchments with long-term and reliable streamflow records. Using the Desktop Reserve Model, instream flow requirements necessary to meet the present ecological state of the streams were determined, and baseflows in excess of these flows were converted into a conservative estimates of allocatable groundwater storages on an annual basis. Results show that groundwater development potential exists in fourteen of the catchments, with upper limits to allocatable groundwater volumes (including present uses) ranging from 0.02 to 3.54 × 106 m3 a-1 (0.10-11.83 mm a-1) per catchment. With a secured availability of these volume 75% of the years, variability between years is assumed to be manageable. A significant (R2 = 0.88) correlation between baseflow index and the drainage time scale for the catchments underscores the physical basis of the methodology and also enables the reduction of the procedure by one step, omitting recession flow analysis. The method serves as an important complementary tool for the assessment of the groundwater part of the Reserve and the Groundwater Resource Directed Measures in

  14. Productive needs and training requirements: philosophy in high school

    Directory of Open Access Journals (Sweden)

    Marta Sueli de Faria Sforni

    2016-12-01

    Full Text Available The discipline of philosophy has not been a constant presence in the basic education curriculum throughout the history of Brazilian education. This inconsistency was the reason that triggered the need to conduct an investigation into the factors that determine its inclusion/exclusion in the Brazilian High School. The survey was conducted through a bibliographic and documental research in order to analyze the historical development of the discipline of philosophy in that level of education. The time period delimitation of the research was from the Colonial Brazil period to the insertion of Brazil in the neoliberal political-economic context. The study revealed that the oscillation of the presence of philosophy in the curricula of schools in Brazil was influenced by the needs of the productive sector, as the formation requirements that were started within the economic system.

  15. Improvement of availability of PWR nuclear plants through the reduction of the time required for refueling/maintenance outages

    Energy Technology Data Exchange (ETDEWEB)

    Mayers, J.B.; Soth, L.G.

    1978-04-01

    The objective of the project, conducted by Commonwealth Research Corporation and Westinghouse Electric Corporation, is to identify improvements in procedures and equipment which will reduce the time required for refueling/maintenance outages at PWR nuclear power plants. The outage of Commonwealth Edison Zion Station Unit 1 in March through May of 1976 was evaluated to identify those items which caused delays and those work activities that offer the potential for significant improvements that could reduce the overall duration of the outage and achieve an improvement in the plant's availability for power production. Modifications in procedures have been developed and were evaluated during one or more outages in 1977. Conceptual designs have been developed for equipment modifications to the refueling system that could reduce the time required for the refueling portion of the outage. The purpose of the interim report is to describe those conceptual designs and to assess their impact upon future outages. Recommendations are included for the implementation of these equipment improvements in a continuation of this program as a demonstration of plant availability benefits that can be realized in PWR nuclear plants already in operation or under construction.

  16. High Energy High Power Battery Exceeding PHEV40 Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Rempel, Jane [TIAX LLC, Lexington, MA (United States)

    2016-03-31

    TIAX has developed long-life lithium-ion cells that can meet and exceed the energy and power targets (200Wh/kg and 800W/kg pulse power) set out by DOE for PHEV40 batteries. To achieve these targets, we selected and scaled-up a high capacity version of our proprietary high energy and high power CAM-7® cathode material. We paired the cathode with a blended anode containing Si-based anode material capable of delivering high capacity and long life. Furthermore, we optimized the anode blend composition, cathode and anode electrode design, and selected binder and electrolyte compositions to achieve not only the best performance, but also long life. By implementing CAM-7 with a Si-based blended anode, we built and tested prototype 18650 cells that delivered measured specific energy of 198Wh/kg total energy and 845W/kg at 10% SOC (projected to 220Wh/kg in state-of-the-art 18650 cell hardware and 250Wh/kg in 15Ah pouch cells). These program demonstration cells achieved 90% capacity retention after 500 cycles in on-going cycle life testing. Moreover, we also tested the baseline CAM-7/graphite system in 18650 cells showing that 70% capacity retention can be achieved after ~4000 cycles (20 months of on-going testing). Ultimately, by simultaneously meeting the PHEV40 power and energy targets and providing long life, we have developed a Li-ion battery system that is smaller, lighter, and less expensive than current state-of-the-art Li-ion batteries.

  17. Assessment of commercially available ion exchange materials for cesium removal from highly alkaline wastes

    Energy Technology Data Exchange (ETDEWEB)

    Brooks, K.P.; Kim, A.Y.; Kurath, D.E.

    1996-04-01

    Approximately 61 million gallons of nuclear waste generated in plutonium production, radionuclide removal campaigns, and research and development activities is stored on the Department of Energy`s Hanford Site, near Richland, Washington. Although the pretreatment process and disposal requirements are still being defined, most pretreatment scenarios include removal of cesium from the aqueous streams. In many cases, after cesium is removed, the dissolved salt cakes and supernates can be disposed of as LLW. Ion exchange has been a leading candidate for this separation. Ion exchange systems have the advantage of simplicity of equipment and operation and provide many theoretical stages in a small space. The organic ion exchange material Duolite{trademark} CS-100 has been selected as the baseline exchanger for conceptual design of the Initial Pretreatment Module (IPM). Use of CS-100 was chosen because it is considered a conservative, technologically feasible approach. During FY 96, final resin down-selection will occur for IPM Title 1 design. Alternate ion exchange materials for cesium exchange will be considered at that time. The purpose of this report is to conduct a search for commercially available ion exchange materials which could potentially replace CS-100. This report will provide where possible a comparison of these resin in their ability to remove low concentrations of cesium from highly alkaline solutions. Materials which show promise can be studied further, while less encouraging resins can be eliminated from consideration.

  18. Verifying cell loss requirements in high-speed communication networks

    Directory of Open Access Journals (Sweden)

    Kerry W. Fendick

    1998-01-01

    Full Text Available In high-speed communication networks it is common to have requirements of very small cell loss probabilities due to buffer overflow. Losses are measured to verify that the cell loss requirements are being met, but it is not clear how to interpret such measurements. We propose methods for determining whether or not cell loss requirements are being met. A key idea is to look at the stream of losses as successive clusters of losses. Often clusters of losses, rather than individual losses, should be regarded as the important “loss events”. Thus we propose modeling the cell loss process by a batch Poisson stochastic process. Successive clusters of losses are assumed to arrive according to a Poisson process. Within each cluster, cell losses do not occur at a single time, but the distance between losses within a cluster should be negligible compared to the distance between clusters. Thus, for the purpose of estimating the cell loss probability, we ignore the spaces between successive cell losses in a cluster of losses. Asymptotic theory suggests that the counting process of losses initiating clusters often should be approximately a Poisson process even though the cell arrival process is not nearly Poisson. The batch Poisson model is relatively easy to test statistically and fit; e.g., the batch-size distribution and the batch arrival rate can readily be estimated from cell loss data. Since batch (cluster sizes may be highly variable, it may be useful to focus on the number of batches instead of the number of cells in a measurement interval. We also propose a method for approximately determining the parameters of a special batch Poisson cell loss with geometric batch-size distribution from a queueing model of the buffer content. For this step, we use a reflected Brownian motion (RBM approximation of a G/D/1/C queueing model. We also use the RBM model to estimate the input burstiness given the cell loss rate. In addition, we use the RBM model to

  19. 高可用CORBA%The Design and Realization of Highly Availability Distributed System of CORBA

    Institute of Scientific and Technical Information of China (English)

    郭乐深; 刘锦德

    2000-01-01

    Recently,while highly available computer systems used for homogeneous environment have been launched into market,those used for heterogeneous environment are still staying vendors' research labs. In this paper,a highly availability distributed system based on CORBA is proposed,and the design and implementation of this system are fully explained. The analysis results show that the scheme presented is an effective approach.

  20. Development of Goat - Palm Oil Integrated Production System : An Assessment Based on Feed Availability and Nutrient Requirements

    Directory of Open Access Journals (Sweden)

    Simon P Ginting

    2006-06-01

    Full Text Available The integration of goats and palm oil plantation is prospective agricultural production systems that exploit the complement relationship among various components in the system . The main components are the oil palm trees, vegetation underneath the trees, processing plant of palm oil bunch, and the goat . The estimation of carrying capacity of the plantation system is based on the quantitative analysis on nutrient supply from various feed resources in the plantation system and nutrient requirements for goat production . The goat demographic parameters, such as, prolificacy, fertility and fecundity are used to estimate the goat population size, dynamics and structures . The development of production model could be based on a certain production target, such as the number of animals sold or the amount of income (demand driven approach, or based on the availability of certain resources such as feed supply (supply driven approach . Using the demand driven approach, and considering 6000 heads of oneyear old goats to fill the Malaysian market as the production target, it is calculated that a population size of 3,636 does and 810 ha of palm oil plantation are required to meet this production target . In a typically medium-size oil palm plantation system (500 ha of oil palm plantation with one unit of small-scale palm oil bunch processing plant ( l ton/hour, the potency to supply metabolisable energy from various feed resources in the system is 2,778,800 Mcal/year, equivalent to a carrying capacity of 5,155 Goat Units/year . This system could carry 2,951 does and 295 bucks to produce 1,116 heads of one-year old goats annually . A medium-size oil palm plantation without processing plant unit, is potential in supplying metabolisable energy of 1,983,300 Mcal/year, equivalent to a carrying capacity of 3,680 Goat Units/year . In order to fill the export market to Malaysia, a number of 10 units of medium sized plantation with small scale plant processing or a

  1. A Runtime Testability Metric for Dynamic High-Availability Component-based Systems

    NARCIS (Netherlands)

    Gonzales-Sanchez, A.; Piel, E.A.B.; Gross, H.G.; Van Gemund, A.J.C.

    2011-01-01

    Runtime testing is emerging as the solution for the integration and assessment of highly dynamic, high availability software systems where traditional development-time integration testing cannot be performed. A prerequisite for runtime testing is the knowledge about to which extent the system can be

  2. Runtime Testability in Dynamic Highly-Availability Component-based Systems

    NARCIS (Netherlands)

    Gonzalez, A.; Piel, E.; Gross, H.G.; Van Gemund, A.J.C.

    2010-01-01

    Runtime testing is emerging as the solution for the integration and assessment of highly dynamic, high availability software systems where traditional development-time integration testing cannot be performed. A prerequisite for runtime testing is the knowledge about to which extent the system can be

  3. Runtime Testability in Dynamic Highly-Availability Component-based Systems

    NARCIS (Netherlands)

    Gonzalez, A.; Piel, E.; Gross, H.G.; Van Gemund, A.J.C.

    2010-01-01

    Runtime testing is emerging as the solution for the integration and assessment of highly dynamic, high availability software systems where traditional development-time integration testing cannot be performed. A prerequisite for runtime testing is the knowledge about to which extent the system can be

  4. A Runtime Testability Metric for Dynamic High-Availability Component-based Systems

    NARCIS (Netherlands)

    Gonzales-Sanchez, A.; Piel, E.A.B.; Gross, H.G.; Van Gemund, A.J.C.

    2011-01-01

    Runtime testing is emerging as the solution for the integration and assessment of highly dynamic, high availability software systems where traditional development-time integration testing cannot be performed. A prerequisite for runtime testing is the knowledge about to which extent the system can be

  5. Analysing changes in water availability to assess environmental water requirements in the Rivirivi River basin, Southern Malawi

    Science.gov (United States)

    Chimtengo, Mavuto; Ngongondo, Cosmo; Tumbare, Michael; Monjerezi, Maurice

    The headwater catchments of the Rivirivi River basin in Malawi play a vital role in meeting downstream water requirements. In recent years, the Rivirivi River flow regime has experienced changes in its hydrological regime, including an increased number of zero-flow days. This study was aimed at investigating some of the causes of these changes. Water quantity indicators were assessed through flow duration analysis of the river flow regime behavior before and after the introduction of the traditional water allocation practices and dam construction. Further, a desktop reserve model was applied to estimate the environmental water requirements. Anthropogenic land use induced change patterns were investigated by time series analysis of satellite imagery and their potential effect on water resources were inferred. The results indicate that there was a considerable difference in average annual stream flow between two identified main periods (between 1963-1983 and 1984-2004) and zero flows increased from 5% to 12%. In addition, the area experienced a 65% reduction in forest cover from 1992 to 2008 which resulted in increased high flow index by 16%. Furthermore, the ecosystems need approximately the range of 35-40% of the MAR to be maintained at Class A and the range of 9-13% of MAR for class D. The results suggest that anthropogenic activities have negatively affected low flow environmental flows requirements by increasing zero flow days in Rivirivi River catchment. However, total water usage remains below the river's MAR and the river can meet all water needs with proper management of the river flow regime.

  6. MySQL High Availability Tools for Building Robust Data Centers

    CERN Document Server

    Bell, Charles; Thalmann, Lars

    2010-01-01

    Server bottlenecks and failures are a fact of life in any database deployment, but they don't have to bring everything to a halt. MySQL has several features that can help you protect your system from outages, whether it's running on hardware, virtual machines, or in the cloud. MySQL High Availability explains how to use these replication, cluster, and monitoring features in a wide range of real-life situations. Written by engineers who designed many of the tools covered inside, this book reveals undocumented or hard-to-find aspects of MySQL reliability and high availability -- knowledge that

  7. TECHNICAL SUPPORT AS A BASIS OF HIGH AVAILABILITY LEVEL AND IT SYSTEM SERVICE QUALITY

    Directory of Open Access Journals (Sweden)

    Dejan Vidojevic

    2007-06-01

    Full Text Available This work presents the development and implementation methodology of technical support in IT1system operation. Methodology is developed and applied in realistic system (Information system of the Tax administration - DIS 2003, which is technically very complex and highly distributed. The results of IT system availability assessment and identification of the critical components are input parameters in the process of establishing of the technical support. The importance of technical support for achieving optimal IT system availability and IT service quality is assessed according to its operation during one year. The history of technical support system operation is a basis for further continuous improvement.

  8. Amenorrhea, ptosis and high insulin requirement in a young girl.

    Science.gov (United States)

    Hari Kumar, K V S; Kumar, Sandeep

    2016-01-01

    Lipodystrophy is an uncommon condition leading to excessive insulin requirement and menstrual abnormalities in young girls with diabetes. Neurological symptoms are uncommon in patients of generalized or partial lipodystrophy. We recently encountered a young girl, who presented with high insulin requirement, amenorrhea and neurological symptoms. Detailed evaluation led to the diagnosis of congenital lipodystrophy and we describe the same in this report. We also highlight the atypical features of the congenital lipodystrophy and the reasons for the excessive insulin requirement in patients with diabetes mellitus.

  9. High light-induced hydrogen peroxide production in Chlamydomonas reinhardtii is increased by high CO2 availability.

    Science.gov (United States)

    Roach, Thomas; Na, Chae Sun; Krieger-Liszkay, Anja

    2015-03-01

    The production of reactive oxygen species (ROS) is an unavoidable part of photosynthesis. Stress that accompanies high light levels and low CO2 availability putatively includes enhanced ROS production in the so-called Mehler reaction. Such conditions are thought to encourage O2 to become an electron acceptor at photosystem I, producing the ROS superoxide anion radical (O2·-) and hydrogen peroxide (H2 O2 ). In contrast, here it is shown in Chlamydomonas reinhardtii that CO2 depletion under high light levels lowered cellular H2 O2 production, and that elevated CO2 levels increased H2 O2 production. Using various photosynthetic and mitochondrial mutants of C. reinhardtii, the chloroplast was identified as the main source of elevated H2 O2 production under high CO2 availability. High light levels under low CO2 availability induced photoprotective mechanisms called non-photochemical quenching, or NPQ, including state transitions (qT) and high energy state quenching (qE). The qE-deficient mutant npq4 produced more H2 O2 than wild-type cells under high light levels, although less so under high CO2 availability, whereas it demonstrated equal or greater enzymatic H2 O2 -degrading capacity. The qT-deficient mutant stt7-9 produced the same H2 O2 as wild-type cells under high CO2 availability. Physiological levels of H2 O2 were able to hinder qT and the induction of state 2, providing an explanation for why under high light levels and high CO2 availability wild-type cells behaved like stt7-9 cells stuck in state 1. © 2015 The Authors The Plant Journal © 2015 John Wiley & Sons Ltd.

  10. Availability and Price of High Quality Day Care and Female Employment

    DEFF Research Database (Denmark)

    Simonsen, Marianne

    In this paper I analyse to what degree availability and price of high quality publicly subsidised childcare affects female employment for women living in couples following maternity leave. The results show that unrestricted access to day care has a significantly positive effct on female employment...

  11. Low nutrient availability reduces high-irradiance–induced viability loss inoceanic phytoplankton

    NARCIS (Netherlands)

    Kulk, G.; van de Poll, W.H.; Visser, R.J.W.; Buma, A.G.J.

    2013-01-01

    In situ viability of oceanic phytoplankton may be relatively low in open oceans. This is assumed to be related to the high-irradiance and low-nutrient conditions typical for oligotrophic regions. However, experimental evidence for this phenomenon was not yet available. In the present study, the impo

  12. A transfer technique for high mobility graphene devices on commercially available hexagonal boron nitride

    NARCIS (Netherlands)

    Zomer, P. J.; Dash, S. P.; Tombros, N.; van Wees, B. J.

    2011-01-01

    We present electronic transport measurements of single and bilayer graphene on commercially available hexagonal boron nitride. We extract mobilities as high as 125 000 cm(2) V-1 s(-1) at room temperature and 275 000 cm(2) V-1 s(-1) at 4.2 K. The excellent quality is supported by the early developmen

  13. Predicting the profile of nutrients available for absorption: from nutrient requirement to animal response and environmental impact

    OpenAIRE

    Dijkstra, J.; Kebreab, E; Mills, J.A.N.; Pellikaan, W.F.; López, S.; Bannink, A; France, J.

    2007-01-01

    Current feed evaluation systems for dairy cattle aim to match nutrient requirements with nutrient intake at pre-defined production levels. These systems were not developed to address, and are not suitable to predict, the responses to dietary changes in terms of production level and product composition, excretion of nutrients to the environment, and nutrition related disorders. The change from a requirement to a response system to meet the needs of various stakeholders requires prediction of t...

  14. High School Physics Availability: Results from the 2012-13 Nationwide Survey of High School Physics Teachers. Focus On

    Science.gov (United States)

    White, Susan; Tesfaye, Casey Langer

    2014-01-01

    In this report, the authors share their analysis of the data from over 3,500 high schools in the U.S. beginning with an examination of the availability of physics in U.S. high schools. The schools in their sample are a nationally-representative random sample of the almost 25,000 high schools in forty-nine of the fifty states. Table 1 shows the…

  15. 42 CFR 137.177 - Is the Self-Governance Tribe required to make its records available to the Secretary?

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Is the Self-Governance Tribe required to make its..., DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Operational Provisions Records § 137.177 Is the Self-Governance Tribe required to make...

  16. Performance Analysis of a Highly Available Home Agent in Mobile Networks

    Directory of Open Access Journals (Sweden)

    Abdelgadir T. Abdelgadir

    2011-01-01

    Full Text Available Problem statement: Network Mobility as a service is provided by the NEMO protocol in IPv6 environments. NEMO is an extension to MIPv6 and thus inherits the same reliability problems of MIPv6. MIPv6 is not reliable because the Home Agent (HA is a single point of failure. In order to provide real-time services for MIPv6 networks, reliability should be considered as part of any high availability solution used to deploy Mobile IPv6 networks. Approach: Many approaches have been taken to solve the problem of HA as a single point of failure. In our proposed solution, failure detection and recovery is handled by the home agent. Therefore, recovery is transparent to the mobile network. Results: In this study we opted for using HA redundancy to provide a highly available home agent solution which achieves recovery times suitable for real-time applications. Conclusion: The results show that achieving high availability in IPv6 based mobile networks which support NEMO is possible.

  17. HIGH RESOLUTION RESISTIVITY LEAK DETECTION DATA PROCESSING & EVALUATION MEHTODS & REQUIREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    SCHOFIELD JS

    2007-10-04

    This document has two purposes: {sm_bullet} Describe how data generated by High Resolution REsistivity (HRR) leak detection (LD) systems deployed during single-shell tank (SST) waste retrieval operations are processed and evaluated. {sm_bullet} Provide the basic review requirements for HRR data when Hrr is deployed as a leak detection method during SST waste retrievals.

  18. Designing high availability systems DFSS and classical reliability techniques with practical real life examples

    CERN Document Server

    Taylor, Zachary

    2014-01-01

    A practical, step-by-step guide to designing world-class, high availability systems using both classical and DFSS reliability techniques Whether designing telecom, aerospace, automotive, medical, financial, or public safety systems, every engineer aims for the utmost reliability and availability in the systems he, or she, designs. But between the dream of world-class performance and reality falls the shadow of complexities that can bedevil even the most rigorous design process. While there are an array of robust predictive engineering tools, there has been no single-source guide to understan

  19. TRICARE; elimination of the non-availability statement (NAS) requirement for non-emergency inpatient mental health care. Final rule.

    Science.gov (United States)

    2013-02-26

    This final rule eliminates the requirement that states a NAS is needed for non-emergency inpatient mental health care in order for a TRICARE Standard beneficiary's claim to be paid. Currently, NAS are required for non-emergency inpatient mental health care for TRICARE Standard beneficiaries who live within a military treatment facility catchment area. At this time, the number of NASs issued is negligible as most mental health admissions are emergency admissions. Requiring a NAS for a relatively few non-emergency inpatient mental health admissions is disproportionate to the cost of maintaining the systems necessary to process and coordinate the NAS.

  20. 78 FR 12951 - TRICARE; Elimination of the Non-Availability Statement (NAS) Requirement for Non-Emergency...

    Science.gov (United States)

    2013-02-26

    ... as one that would result in an annual effect of $100 million or more on the national economy or which... the exception of maternity services, the ASD(HA) may require an NAS prior to TRICARE cost-sharing...

  1. Availability and Price of High Quality Day Care and Female Employment

    DEFF Research Database (Denmark)

    Simonsen, Marianne

    In this paper I analyse to what degree availability and price of high quality publicly subsidised childcare affects female employment for women living in couples following maternity leave. The results show that unrestricted access to day care has a significantly positive effct on female employmen.......The price effect is significantly negative: An increase in the price of child care of C=1 will decrease the female employment with 0.08% corresponding to a price elasticity of −0.17. This effect prevails during the first 12 months after childbirth.......In this paper I analyse to what degree availability and price of high quality publicly subsidised childcare affects female employment for women living in couples following maternity leave. The results show that unrestricted access to day care has a significantly positive effct on female employment...

  2. Deeper snow alters soil nutrient availability and leaf nutrient status in high Arctic tundra

    DEFF Research Database (Denmark)

    Semenchuk, Philipp R.; Elberling, Bo; Amtorp, Cecilie

    2015-01-01

    Nitrogen (N) mineralization, nutrient availability, and plant growth in the Arctic are often restricted by low temperatures. Predicted increases of cold-season temperatures may be important for plant nutrient availability and growth, given that N mineralization is also taking place during the cold...... season. Changing nutrient availability may be reflected in plant N and chlorophyll content and lead to increased photosynthetic capacity, plant growth, and ultimately carbon (C) assimilation by plants. In this study, we increased snow depth and thereby cold-season soil temperatures in high Arctic...... for some species. Responses to cold-season soil warming are vegetation type- and species-specific, with potentially stronger responses in moister vegetation types. This study therefore highlights the contrasting effect of snow in a tundra landscape and has important implications for projections of whole...

  3. Unusually high food availability in Kaikoura Canyon linked to distinct deep-sea nematode community

    Science.gov (United States)

    Leduc, D.; Rowden, A. A.; Nodder, S. D.; Berkenbusch, K.; Probert, P. K.; Hadfield, M. G.

    2014-06-01

    Kaikoura Canyon, on the eastern New Zealand continental margin, is the most productive, non-chemosynthetic deep-sea habitat described to date, with megafaunal biomass 100-fold higher than those of other deep-sea habitats. The present study, which focused on free-living nematodes, provides the first comparison of faunal community structure and diversity between Kaikoura Canyon and nearby open slope habitats. Results show substantially higher food availability in the canyon relative to open slope sediments, which probably reflects greater levels of primary productivity above the canyon, coupled with downwelling and/or topographically-induced channelling, which serves to concentrate surface-derived organic matter along the canyon axis. This high food availability appears to be responsible for the elevated nematode biomass in Kaikoura Canyon, with values exceeding all published nematode biomass data from canyons elsewhere. There was also markedly lower local species diversity of nematodes inside the canyon relative to the open slope habitat, as well as a distinct community structure. The canyon community was dominated by species, such as Sabateria pulchra, which were absent from the open slope and are typically associated with highly eutrophic and/or disturbed environments. The presence of these taxa, as well as the low observed diversity, is likely to reflect the high food availability, and potentially the high levels of physically and biologically induced disturbance within the canyon. Kaikoura Canyon is a relatively small habitat characterised by different environmental conditions that makes a disproportionate contribution to deep-sea diversity in the region, despite its low species richness.

  4. Future water availability in North African dams simulated by high-resolution regional climate models

    Science.gov (United States)

    Tramblay, Yves; Jarlan, Lionel; Hanich, Lahoucine; Somot, Samuel

    2016-04-01

    In North Africa, the countries of Morocco, Algeria and Tunisia are already experiencing water scarcity and a strong interannual variability of precipitation. To better manage their existing water resources, several dams and reservoirs have been built on most large river catchments. The objective of this study is to provide quantitative scenarios of future changes in water availability for the 47 major dams and reservoirs catchments located in North Africa. An ensemble of regional climate models (RCM) with a spatial resolution of 12km, driven by different general circulation models (GCM), from the EuroCORDEX experiment have been considered to analyze the projected changes on temperature, precipitation and potential evapotranspiration (PET) for two scenarios (RCP4.5 and RCP8.5) and two time horizons (2040-2065 and 2065-2090). PET is estimated from RCM outputs either with the FAO-Penman-Monteith (PM) equation, requiring air temperature, relative humidity, net radiation and wind, or with the Hargreave Samani (HS) equation, requiring only air temperature. The water balance is analyzed by comparing the climatic demand and supply of water, considering that for most of these catchments groundwater storage is negligible over long time periods. Results indicated a future temperature increase for all catchments between +1.8° and +4.2°, depending on the emission scenario and the time period considered. Precipitation is projected to decrease between -14% to -27%, mainly in winter and spring, with a strong East to West gradient. PET computed from PM or HS formulas provided very similar estimates and projections, ranging between +7% to +18%. Changes in PET are mostly driven by rising temperatures and are greatest during dry summer months than for the wet winter season. Therefore the increased PET has a lower impact than declining precipitation on future water availability, which is expected to decrease by -19% to -33% on average.

  5. Predicting the profile of nutrients available for absorption: from nutrient requirement to animal response and environmental impact

    NARCIS (Netherlands)

    Dijkstra, J.; Kebreab, E.; Mills, J.A.N.; Pellikaan, W.F.; López, S.; Bannink, A.; France, J.

    2007-01-01

    Current feed evaluation systems for dairy cattle aim to match nutrient requirements with nutrient intake at pre-defined production levels. These systems were not developed to address, and are not suitable to predict, the responses to dietary changes in terms of production level and product compositi

  6. Innovative use of controlled availability fertilizers with high performance for intensive agriculture and environmental conservation

    Institute of Scientific and Technical Information of China (English)

    Sadao SHOJI

    2005-01-01

    A variety of slow release fertilizers, controlled release (availability) fertilizers (CAFs),and stability fertilizers have been developed in response to the serious drawbacks of the conventional fertilizers since the early 1960's. Of these fertilizers, CAFs which are coated with resin are consumed in the largest quantity in the world. Selecting CAFs with higher performance, the author will discuss about: 1) Innovation of agro-technologies for various field crops including new concepts of fertilizer application, 2) high yielding of field crops, 3) enhancing quality and safety of farm products, and 4) controlling the adverse effect of intensive agriculture on the environment.

  7. High-frequency nutrient monitoring to infer seasonal patterns in catchment source availability, mobilisation and delivery.

    Science.gov (United States)

    Bende-Michl, Ulrike; Verburg, Kirsten; Cresswell, Hamish P

    2013-11-01

    To explore the value of high-frequency monitoring to characterise and explain riverine nutrient concentration dynamics, total phosphorus (TP), reactive phosphorus (RP), ammonium (NH4-N) and nitrate (NO3-N) concentrations were measured hourly over a 2-year period in the Duck River, in north-western Tasmania, Australia, draining a 369-km(2) mixed land use catchment area. River discharge was observed at the same location and frequency, spanning a wide range of hydrological conditions. Nutrient concentrations changed rapidly and were higher than previously observed. Maximum nutrient concentrations were 2,577 μg L(-1) TP, 1,572 μg L(-1) RP, 972 μg L(-1) NH₄-N and 1,983 μg L(-1) NO₃-N, respectively. Different nutrient response patterns were evident at seasonal, individual event and diurnal time scales-patterns that had gone largely undetected in previous less frequent water quality sampling. Interpretation of these patterns in terms of nutrient source availability, mobilisation and delivery to the stream allowed the development of a conceptual model of catchment nutrient dynamics. Functional stages of nutrient release were identified for the Duck River catchment and were supported by a cluster analysis which confirmed the similarities and differences in nutrient responses caused by the sequence of hydrologic events: (1) a build-up of nutrients during periods with low hydrologic activity, (2) flushing of readily available nutrient sources at the onset of the high flow period, followed by (3) a switch from transport to supply limitation, (4) the accessibility of new nutrient sources with increasing catchment wetness and hydrologic connectivity and (5) high nutrient spikes occurring when new sources become available that are easily mobilised with quickly re-established hydrologic connectivity. Diurnal variations that could be influenced by riverine processes and/or localised point sources were also identified as part of stage (1) and during late recession of some of

  8. 20 CFR 662.250 - Where and to what extent must required One-Stop partners make core services available?

    Science.gov (United States)

    2010-04-01

    ... available by the provision of appropriate technology at the comprehensive One-Stop center, by co-locating personnel at the center, cross-training of staff, or through a cost reimbursement or other agreement between... TRAINING ADMINISTRATION, DEPARTMENT OF LABOR DESCRIPTION OF THE ONE-STOP SYSTEM UNDER TITLE I OF THE...

  9. Sexually transmitted infections treatment and care available to high risk populations in Pakistan.

    Science.gov (United States)

    Rahimtoola, Minal; Hussain, Hamidah; Khowaja, Saira N; Khan, Aamir J

    2008-01-01

    Limited literature exists on the quality and availability of treatment and care of sexually transmitted infections (STIs) in Pakistan. This article aims to document existing services for the care and treatment of STIs available in Pakistan's public and private sectors to high risk groups (HRG), particularly the transgendered population. We conducted a cross-sectional survey to document STI services in Lahore, Karachi, Rawalpindi, Peshawar, and Quetta. Seventy-three interviews were administered with health service providers at the 3 largest public sector hospitals in each city, as well as with general physicians and traditional healers in the private sector. Twenty-five nongovernmental organizations (NGO) providing STI services were also interviewed. Fewer than 45% of private and public sector general practitioners had been trained in STI treatment after the completion of their medical curriculum, and none of the traditional healers had received any formal training or information on STIs. The World Health Organization (WHO) syndromic management guidelines were followed for STI management by 29% of public and private sector doctors and 5% of traditional healers. STI drugs were available at no cost at 44% of NGOs and at some public sector hospitals. Our findings show that although providers do treat HRGs for STIs, there are significant limitations in their ability to provide these services. These deterrents include, but are not limited to, a lack of STI training of service providers, privacy and adherence to recommended WHO syndromic management guidelines, and costly diagnostic and consultation fees.

  10. JOSHUA: Symmetric Active/Active Replication for Highly Available HPC Job and Resource Management

    Energy Technology Data Exchange (ETDEWEB)

    Uhlemann, Kai [ORNL; Engelmann, Christian [ORNL; Scott, Steven L [ORNL

    2006-01-01

    Most of today's HPC systems employ a single head node for control, which represents a single point of failure as it interrupts an entire HPC system upon failure. Furthermore, it is also a single point of control as it disables an entire HPC system until repair. One of the most important HPC system service running on the head node is the job and resource management. If it goes down, all currently running jobs loose the service they report back to. They have to be restarted once the head node is up and running again. With this paper, we present a generic approach for providing symmetric active/active replication for highly available HPC job and resource management. The JOSHUA solution provides a virtually synchronous environment for continuous availability without any interruption of service and without any loss of state. Replication is performed externally via the PBS service interface without the need to modify any service code. Test results as well as a reliability analysis of our proof-of-concept prototype implementation show that continuous availability can be provided by JOSHUA with an acceptable performance trade-off.

  11. High sensitivity of broadleaf trees to water availability in northeastern United States

    Science.gov (United States)

    Levesque, Mathieu; Andreu-Hayles, Laia; Pederson, Neil

    2016-04-01

    Broadleaf dominated forests of eastern US cover more than one million km2 and provide ecosystem services to millions of people. High species diversity and a varied sensitivity to drought make it uncertain whether these forests will be carbon sinks or sources under climate change. Ongoing climate change, increased in atmospheric CO2 concentration (ca) and strong reductions in acidic depositions are expected to alter growth and gas exchange of trees, and ultimately forest productivity. Still, the magnitude of these effects is unclear. A better comprehension of the species-specific responses to environmental changes will better inform models and managers on the vulnerability and resiliency of these forests. Here, we combined tree-ring width data with δ13C and δ18O measurements to investigate growth and physiological responses of red oak (Quercus rubra L.) and tulip poplar (Liriodendron tulipifera L.) in northeastern US to changes in water availability, ca and acidic depositions for the period 1950-2014. Based on structural equation modeling approaches, we found that summer water availability (June-August) is the main environmental variable driving growth, water-use efficiency and δ18O of broadleaf trees whereas ca and acidic depositions have little effects. This high sensitivity to moisture availability was also supported by the very strong correlations found between summer vapor pressure deficit (VPD) and tree-ring δ13C (r = 0.67 and 0.71), and δ18O series (r = 0.62 and 0.72), for red oak and tulip poplar, respectively. In contrast, tree-ring width was less sensitive to summer VPD (r = -0.44 and-0.31). Since the mid 1980s, pluvial conditions occurring in northeastern US have increased stomatal conductance, carbon uptake, and growth of both species. Further, the strong spatial field correlations found between the tree-ring δ13C and δ18O and summer VPD indicate a greater sensitivity of eastern US broadleaf forests to moisture availability than previously known

  12. Next Generation Fast RF Interlock Module and ATCA Adapter for ILC High Availability RF Test Station Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, R

    2009-10-17

    High availability interlocks and controls are required for the ILC (International Linear Collider) L-Band high power RF stations. A new F3 (Fast Fault Finder) VME module has been developed to process both fast and slow interlocks using FPGA logic to detect the interlock trip excursions. This combination eliminates the need for separate PLC (Programmable Logic Controller) control of slow interlocks. Modules are chained together to accommodate as many inputs as needed. In the next phase of development the F3's will be ported to the new industry standard ATCA (Advanced Telecom Computing Architecture) crate (shelf) via a specially designed VME adapter module with IPMI (Intelligent Platform Management Interface). The goal is to demonstrate auto-failover and hot-swap for future partially redundant systems.

  13. LHCb: Performance evaluation and capacity planning for a scalable and highly available virtulization infrastructure for the LHCb experiment

    CERN Multimedia

    Sborzacchi, F; Neufeld, N

    2013-01-01

    The virtual computing is often run to satisfy different needs: reduce costs, reduce resources, simplify maintenance and the last but not the least add flexibility. The use of Virtualization in a complex system such as a farm of PCs that control the hardware of an experiment (PLC, power supplies ,gas, magnets..) put us in a condition where not only an High Performance requirements need to be carefully considered but also a deep analysis of strategies to achieve a certain level of High Availability. We conducted a performance evaluation on different and comparable storage/network/virtulization platforms. The performance is measured using a series of independent benchmarks , testing the speed an the stability of multiple VMs runnng heavy-load operations on the I/O of virtualized storage and the virtualized network. The result from the benchmark tests allowed us to study and evaluate how the different workloads of Vm interact with the Hardware/Software resource layers.

  14. Experience and Lessons learnt from running high availability databases on Network Attached Storage

    CERN Document Server

    Guijarro, Juan Manuel; Segura Chinchilla, Nilo

    2008-01-01

    The Database and Engineering Services Group of CERN's Information Technology Department provides the Oracle based Central Data Base services used in many activities at CERN. In order to provide High Availability and ease management for those services, a NAS (Network Attached Storage) based infrastructure has been set up. It runs several instances of the Oracle RAC (Real Application Cluster) using NFS as share disk space for RAC purposes and Data hosting. It is composed of two private LAN's to provide access to the NAS file servers and Oracle RAC interconnect, both using network bonding. NAS nodes are configured in partnership to prevent having single points of failure and to provide automatic NAS fail-over. This presentation describes that infrastructure and gives some advice on how to automate its management and setup using a Fabric Management framework such as Quattor. It also covers aspects related with NAS Performance and Monitoring as well Data Backup and Archive of such facility using already existing i...

  15. Experience and Lessons learnt from running High Availability Databases on Network Attached Storage

    CERN Document Server

    Guijarro, Manuel

    2008-01-01

    The Database and Engineering Services Group of CERN's Information Technology Department supplies the Oracle Central Database services used in many activities at CERN. In order to provide High Availability and ease management for those services, a NAS (Network Attached Storage) based infrastructure has been setup. It runs several instances of the Oracle RAC (Real Application Cluster) using NFS (Network File System) as shared disk space for RAC purposes and Data hosting. It is composed of two private LANs (Local Area Network), one to provide access to the NAS filers and a second to implement the Oracle RAC private interconnect, both using Network Bonding. NAS filers are configured in partnership to prevent having single points of failure and to provide automatic NAS filer fail-over.

  16. CMS experience of running glideinWMS in High Availability mode

    CERN Document Server

    Sfiligoi, Igor; Belforte, Stefano; Mc Crea, Alison Jean; Larson, Krista Elaine; Zvada, Marian; Holzman, Burt; P Mhashilkar; Bradley, Daniel Charles; Saiz Santos, Maria Dolores; Fanzago, Federica; Gutsche, Oliver; Martin, Terrence; Wuerthwein, Frank Karl

    2013-01-01

    The CMS experiment at the Large Hadron Collider is relying on the HTCondor-based glideinWMS batch system to handle most of its distributed computing needs. In order to minimize the risk of disruptions due to software and hardware problems, and also to simplify the maintenance procedures, CMS has set up its glideinWMS instance to use most of the attainable High Availability (HA) features. The setup involves running services distributed over multiple nodes, which in turn are located in several physical locations, including Geneva, Switzerland, Chicago, Illinois and San Diego, California. This paper describes the setup used by CMS, the HA limits of this setup, as well as a description of the actual operational experience spanning many months.

  17. Low-Cost Solutions Using the Infrastructure as a Service with High Availability and Virtualization Model

    Directory of Open Access Journals (Sweden)

    Cesar Armando Moreira Zambrano

    2017-02-01

    Full Text Available This paper presents the results obtained from the implementation of an infrastructure to improve technological services of email, virtual learning environment, digital repository and virtual library at the Polytechnic Agricultural Higher School of Manabí (Polytechnic School of Agriculture of Manabí, ESPAM, through the use of high availability and virtualization mechanisms to provide more reliable resources. Virtualization is an empowering and cutting-edge technology that is transforming the operation of technological services, but it involves a paradigm shift in serviceoriented information technologies and cloud computing. To execute each of the processes the V-cycle methodology was used as a strategy. Virtualization services empowers companies and institutions by transforming how they operate to be at the forefront of innovation in their services as a technological solution. So the implementation of redundant technology in the ESPAM, has allowed its technological services are always operative, for the benefit of the university community, because if there were failures in the main system or services, the backups will be enabled quickly allowing the systems come into operation immediately.

  18. Implementasi Cloud Storage Menggunakan OwnCloud yang High-Availability

    Directory of Open Access Journals (Sweden)

    Ikhwan Ar-Razy

    2016-04-01

    Full Text Available Implementation of practicum courses in Department of Computer Engineering Diponegoro University has some drawbacks, one of them is a lot of lab assistant and the practitioner experiencing difficulties in terms of archiving. One solution to solve the problem is implementing a shared file storage system that is easy and can be accessed by both practitioners or lab assistants. The purpose of this research is to build a cloud-based storage systems that are reliable to preventing crash damage hardware and high availability. The purpose of this research is achieved by designing the appropriate methodology. The result of this research is a storage system that is on the server side by using virtualization and data replication (DRBD as a storage method. The system is composed of two physical servers and one virtual server. Physical servers are using Proxmox VE as operating system and virtual server is using Ubuntu Server as operating system. OwnCloud applications and files are stored in the virtual server. File storage system has several major functions, which are: upload, download, user management, remove, and restore. The functions are executed through web pages, desktop application and Android application.

  19. Precision cosmology with time delay lenses: high resolution imaging requirements

    CERN Document Server

    Meng, Xiao-Lei; Agnello, Adriano; Auger, Matthew W; Liao, Kai; Marshall, Philip J

    2015-01-01

    Lens time delays are a powerful probe of cosmology, provided that the gravitational potential of the main deflector can be modeled with sufficient precision. Recent work has shown that this can be achieved by detailed modeling of the host galaxies of lensed quasars, which appear as "Einstein Rings" in high resolution images. We carry out a systematic exploration of the high resolution imaging required to exploit the thousands of lensed quasars that will be discovered by current and upcoming surveys with the next decade. Specifically, we simulate realistic lens systems as imaged by the Hubble Space Telescope (HST), James Webb Space Telescope (JWST), and ground based adaptive optics images taken with Keck or the Thirty Meter Telescope (TMT). We compare the performance of these pointed observations with that of images taken by the Euclid (VIS), Wide-Field Infrared Survey Telescope (WFIRST) and Large Synoptic Survey Telescope (LSST) surveys. We use as our metric the precision with which the slope $\\gamma'$ of the...

  20. Large Scale Computing and Storage Requirements for High Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, Richard A.; Wasserman, Harvey

    2010-11-24

    The National Energy Research Scientific Computing Center (NERSC) is the leading scientific computing facility for the Department of Energy's Office of Science, providing high-performance computing (HPC) resources to more than 3,000 researchers working on about 400 projects. NERSC provides large-scale computing resources and, crucially, the support and expertise needed for scientists to make effective use of them. In November 2009, NERSC, DOE's Office of Advanced Scientific Computing Research (ASCR), and DOE's Office of High Energy Physics (HEP) held a workshop to characterize the HPC resources needed at NERSC to support HEP research through the next three to five years. The effort is part of NERSC's legacy of anticipating users needs and deploying resources to meet those demands. The workshop revealed several key points, in addition to achieving its goal of collecting and characterizing computing requirements. The chief findings: (1) Science teams need access to a significant increase in computational resources to meet their research goals; (2) Research teams need to be able to read, write, transfer, store online, archive, analyze, and share huge volumes of data; (3) Science teams need guidance and support to implement their codes on future architectures; and (4) Projects need predictable, rapid turnaround of their computational jobs to meet mission-critical time constraints. This report expands upon these key points and includes others. It also presents a number of case studies as representative of the research conducted within HEP. Workshop participants were asked to codify their requirements in this case study format, summarizing their science goals, methods of solution, current and three-to-five year computing requirements, and software and support needs. Participants were also asked to describe their strategy for computing in the highly parallel, multi-core environment that is expected to dominate HPC architectures over the next few years

  1. High Affinity Iron Permease is Required for Virulence of Rhizopus oryzae

    Science.gov (United States)

    Rhizopus oryzae is the most common cause of mucormycosis. Clinical and animal model data clearly demonstrate that the presence of elevated available serum iron predisposes the host to develop mucormycosis. The high affinity iron permease gene (rFTR1) is required for R. oryzae iron transport in iro...

  2. Precision cosmology with time delay lenses: High resolution imaging requirements

    Energy Technology Data Exchange (ETDEWEB)

    Meng, Xiao -Lei [Beijing Normal Univ., Beijing (China); Univ. of California, Santa Barbara, CA (United States); Treu, Tommaso [Univ. of California, Santa Barbara, CA (United States); Univ. of California, Los Angeles, CA (United States); Agnello, Adriano [Univ. of California, Santa Barbara, CA (United States); Univ. of California, Los Angeles, CA (United States); Auger, Matthew W. [Univ. of Cambridge, Cambridge (United Kingdom); Liao, Kai [Beijing Normal Univ., Beijing (China); Univ. of California, Santa Barbara, CA (United States); Univ. of California, Los Angeles, CA (United States); Marshall, Philip J. [Stanford Univ., Stanford, CA (United States)

    2015-09-28

    Lens time delays are a powerful probe of cosmology, provided that the gravitational potential of the main deflector can be modeled with sufficient precision. Recent work has shown that this can be achieved by detailed modeling of the host galaxies of lensed quasars, which appear as ``Einstein Rings'' in high resolution images. The distortion of these arcs and counter-arcs, as measured over a large number of pixels, provides tight constraints on the difference between the gravitational potential between the quasar image positions, and thus on cosmology in combination with the measured time delay. We carry out a systematic exploration of the high resolution imaging required to exploit the thousands of lensed quasars that will be discovered by current and upcoming surveys with the next decade. Specifically, we simulate realistic lens systems as imaged by the Hubble Space Telescope (HST), James Webb Space Telescope (JWST), and ground based adaptive optics images taken with Keck or the Thirty Meter Telescope (TMT). We compare the performance of these pointed observations with that of images taken by the Euclid (VIS), Wide-Field Infrared Survey Telescope (WFIRST) and Large Synoptic Survey Telescope (LSST) surveys. We use as our metric the precision with which the slope γ' of the total mass density profile ρtot∝ r–γ' for the main deflector can be measured. Ideally, we require that the statistical error on γ' be less than 0.02, such that it is subdominant to other sources of random and systematic uncertainties. We find that survey data will likely have sufficient depth and resolution to meet the target only for the brighter gravitational lens systems, comparable to those discovered by the SDSS survey. For fainter systems, that will be discovered by current and future surveys, targeted follow-up will be required. Furthermore, the exposure time required with upcoming facilitites such as JWST, the Keck Next Generation Adaptive

  3. ArcticDEM; A Publically Available, High Resolution Elevation Model of the Arctic

    Science.gov (United States)

    Morin, Paul; Porter, Claire; Cloutier, Michael; Howat, Ian; Noh, Myoung-Jong; Willis, Michael; Bates, Brian; Willamson, Cathleen; Peterman, Kennith

    2016-04-01

    A Digital Elevation Model (DEM) of the Arctic is needed for a large number of reasons, including: measuring and understanding rapid, ongoing changes to the Arctic landscape resulting from climate change and human use and mitigation and adaptation planning for Arctic communities. The topography of the Arctic is more poorly mapped than most other regions of Earth due to logistical costs and the limits of satellite missions with low-latitude inclinations. A convergence of civilian, high-quality sub-meter stereo imagery; petascale computing and open source photogrammetry software has made it possible to produce a complete, very high resolution (2 to 8-meter posting), elevation model of the Arctic. A partnership between the US National Geospatial-intelligence Agency and a team led by the US National Science Foundation funded Polar Geospatial Center is using stereo imagery from DigitalGlobe's Worldview-1, 2 and 3 satellites and the Ohio State University's Surface Extraction with TIN-based Search-space Minimization (SETSM) software running on the University of Illinois's Blue Water supercomputer to address this challenge. The final product will be a seemless, 2-m posting digital surface model mosaic of the entire Arctic above 60 North including all of Alaska, Greenland and Kamchatka. We will also make available the more than 300,000 individual time-stamped DSM strip pairs that were used to assemble the mosaic. The Arctic DEM will have a vertical precision of better than 0.5m and can be used to examine changes in land surfaces such as those caused by permafrost degradation or the evolution of arctic rivers and floodplains. The data set can also be used to highlight changing geomorphology due to Earth surface mass transport processes occurring in active volcanic and glacial environments. When complete the ArcticDEM will catapult the Arctic from the worst to among the best mapped regions on Earth.

  4. Computational Environments and Analysis methods available on the NCI High Performance Computing (HPC) and High Performance Data (HPD) Platform

    Science.gov (United States)

    Evans, B. J. K.; Foster, C.; Minchin, S. A.; Pugh, T.; Lewis, A.; Wyborn, L. A.; Evans, B. J.; Uhlherr, A.

    2014-12-01

    The National Computational Infrastructure (NCI) has established a powerful in-situ computational environment to enable both high performance computing and data-intensive science across a wide spectrum of national environmental data collections - in particular climate, observational data and geoscientific assets. This paper examines 1) the computational environments that supports the modelling and data processing pipelines, 2) the analysis environments and methods to support data analysis, and 3) the progress in addressing harmonisation of the underlying data collections for future transdisciplinary research that enable accurate climate projections. NCI makes available 10+ PB major data collections from both the government and research sectors based on six themes: 1) weather, climate, and earth system science model simulations, 2) marine and earth observations, 3) geosciences, 4) terrestrial ecosystems, 5) water and hydrology, and 6) astronomy, social and biosciences. Collectively they span the lithosphere, crust, biosphere, hydrosphere, troposphere, and stratosphere. The data is largely sourced from NCI's partners (which include the custodians of many of the national scientific records), major research communities, and collaborating overseas organisations. The data is accessible within an integrated HPC-HPD environment - a 1.2 PFlop supercomputer (Raijin), a HPC class 3000 core OpenStack cloud system and several highly connected large scale and high-bandwidth Lustre filesystems. This computational environment supports a catalogue of integrated reusable software and workflows from earth system and ecosystem modelling, weather research, satellite and other observed data processing and analysis. To enable transdisciplinary research on this scale, data needs to be harmonised so that researchers can readily apply techniques and software across the corpus of data available and not be constrained to work within artificial disciplinary boundaries. Future challenges will

  5. Central noradrenaline transporter availability in highly obese, non-depressed individuals

    Energy Technology Data Exchange (ETDEWEB)

    Hesse, Swen; Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Leipzig University Medical Centre, Integrated Treatment and Research Centre (IFB) Adiposity Diseases, Leipzig (Germany); Becker, Georg-Alexander; Bresch, Anke; Luthardt, Julia; Patt, Marianne; Meyer, Philipp M. [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Rullmann, Michael [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Leipzig University Medical Centre, Integrated Treatment and Research Centre (IFB) Adiposity Diseases, Leipzig (Germany); Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig (Germany); Hankir, Mohammed K.; Zientek, Franziska; Reissig, Georg; Fenske, Wiebke K. [Leipzig University Medical Centre, Integrated Treatment and Research Centre (IFB) Adiposity Diseases, Leipzig (Germany); Arelin, Katrin [Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig (Germany); University of Leipzig, Day Clinic for Cognitive Neurology, Leipzig (Germany); Lobsien, Donald [University of Leipzig, Department of Neuroradiology, Leipzig (Germany); Mueller, Ulrich [University of Cambridge, Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, Cambridge (United Kingdom); Baldofski, S.; Hilbert, Anja [Leipzig University Medical Centre, Integrated Treatment and Research Centre (IFB) Adiposity Diseases, Leipzig (Germany); University of Leipzig, Department of Medical Psychology and Medical Sociology, Leipzig (Germany); Blueher, Matthias [University of Leipzig, Department of Internal Medicine, Leipzig (Germany); Fasshauer, Mathias; Stumvoll, Michael [Leipzig University Medical Centre, Integrated Treatment and Research Centre (IFB) Adiposity Diseases, Leipzig (Germany); University of Leipzig, Department of Internal Medicine, Leipzig (Germany); Ding, Yu-Shin [New York University School of Medicine, Departments of Radiology and Psychiatry, New York, NY (United States)

    2017-06-15

    The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate. We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S,S-[{sup 11}C]O-methylreboxetine (MRB) in twenty subjects comprising ten highly obese (body mass index BMI > 35 kg/m{sup 2}), metabolically healthy, non-depressed individuals and ten non-obese (BMI < 30 kg/m{sup 2}) healthy controls. Overall, we found no significant differences in binding potential (BP{sub ND}) values between obese and non-obese individuals in the investigated brain regions, including the NAT-rich thalamus (0.40 ± 0.14 vs. 0.41 ± 0.18; p = 0.84) though additional discriminant analysis correctly identified individual group affiliation based on regional BP{sub ND} in all but one (control) case. Furthermore, inter-regional correlation analyses indicated different BP{sub ND} patterns between both groups but this did not survive testing for multiple comparions. Our data do not find an overall involvement of NAT changes in human obesity. However, preliminary secondary findings of distinct regional and associative patterns warrant further investigation. (orig.)

  6. Future materials requirements for high temperature power engineering components

    Energy Technology Data Exchange (ETDEWEB)

    Marriott, J.B. (Commission of the European Communities, Petten (Netherlands). Joint Nuclear Research Center)

    1989-08-01

    The two dominant technologies in power engineering are steam and gas turbines. These are, however, dependent on a prior stage of combustion and, perhaps, gasification. There is a continuous drive towards higher operating efficiencies and greater reliability of the units. This leads to a need for larger components to operate at higher temperatures and pressures and hence under more arduous conditions of mechanical and corrosive loading for times which may exceed 200,000 h (30 years). Some examples are used to illustrate generic features of the materials problems towards which research and development is aimed. In some components the high temperature time-dependent mechanical properties dominate, a good example being gas turbine blades. Uniformity of the time-dependent mechanical properties plus fracture toughness is difficult to attain in the very large forgings required for steam turbines. Within the heat generation units (boiler tubes, headers, etc.) the mechanical requirements are severe, but would not be critical without the constraints imposed by the need for inexpensive corrosion and erosion resistance. (author).

  7. ScreenMill: A freely available software suite for growth measurement, analysis and visualization of high-throughput screen data

    Directory of Open Access Journals (Sweden)

    Rothstein Rodney

    2010-06-01

    Full Text Available Abstract Background Many high-throughput genomic experiments, such as Synthetic Genetic Array and yeast two-hybrid, use colony growth on solid media as a screen metric. These experiments routinely generate over 100,000 data points, making data analysis a time consuming and painstaking process. Here we describe ScreenMill, a new software suite that automates image analysis and simplifies data review and analysis for high-throughput biological experiments. Results The ScreenMill, software suite includes three software tools or "engines": an open source Colony Measurement Engine (CM Engine to quantitate colony growth data from plate images, a web-based Data Review Engine (DR Engine to validate and analyze quantitative screen data, and a web-based Statistics Visualization Engine (SV Engine to visualize screen data with statistical information overlaid. The methods and software described here can be applied to any screen in which growth is measured by colony size. In addition, the DR Engine and SV Engine can be used to visualize and analyze other types of quantitative high-throughput data. Conclusions ScreenMill automates quantification, analysis and visualization of high-throughput screen data. The algorithms implemented in ScreenMill are transparent allowing users to be confident about the results ScreenMill produces. Taken together, the tools of ScreenMill offer biologists a simple and flexible way of analyzing their data, without requiring programming skills.

  8. Statistical analysis of the limitation of half integer resonances on the available momentum acceptance of the High Energy Photon Source

    Science.gov (United States)

    Jiao, Yi; Duan, Zhe

    2017-01-01

    In a diffraction-limited storage ring, half integer resonances can have strong effects on the beam dynamics, associated with the large detuning terms from the strong focusing and strong sextupoles as required for an ultralow emittance. In this study, the limitation of half integer resonances on the available momentum acceptance (MA) was statistically analyzed based on one design of the High Energy Photon Source (HEPS). It was found that the probability of MA reduction due to crossing of half integer resonances is closely correlated with the level of beta beats at the nominal tunes, but independent of the error sources. The analysis indicated that for the presented HEPS lattice design, the rms amplitude of beta beats should be kept below 1.5% horizontally and 2.5% vertically to reach a small MA reduction probability of about 1%.

  9. Membrane requirements for high-flux and convective therapies.

    Science.gov (United States)

    Bowry, Sudhir Kumar

    2011-01-01

    Worldwide, high-flux dialysis (HF-HD) has now surpassed low-flux dialysis (LF-HD) as the predominant treatment modality, recognition that removal of larger uremic retention solutes is desirable for the treatment of patients with end-stage chronic kidney disease (CKD). An even more advanced form of HF-HD in terms of removal of a broad spectrum of uremic toxins is on-line hemodiafiltration (HDF), involving convective transport mechanisms for solute removal. With the modality reaching considerable technical maturity over the last two decades, on-line HDF is now recognized for its clinical efficiency and effectiveness, versatility and safety. Such has been the success of on-line HDF that, in Europe, more patients are treated with on-line HDF than even peritoneal dialysis. Fabrication of high-flux membranes for convective therapies is more than a matter of simply making the membrane 'more open' or of increasing the membrane pore size which is not the only determinant for achieving higher convection. While convective transport of larger uremic retention solutes primarily demands membranes with high hydraulic permeability and sieving capabilities, the making of a modern dialysis membrane involves several other considerations that culminate in the delivery of an effective and safe therapy. In this communication I outline the essential membrane requirements and principles for solute removal by convection, as well of meeting additional features related to the therapy. The basic principles of the membrane manufacturing processes by which desired membrane morphology is derived for the separation phenomena involved in dialysis are further described. An awareness of this enables one to appreciate that, depending on the individual constituents and variations of the manufacturing processes, fabrication of all high-flux membranes entails achieving a balance between the ideal or desired criteria for blood purification. Dialysis membranes for convective therapies, even from the same

  10. High-resolution prediction of soil available water content within the crop root zone

    Science.gov (United States)

    Haghverdi, Amir; Leib, Brian G.; Washington-Allen, Robert A.; Ayers, Paul D.; Buschermohle, Michael J.

    2015-11-01

    A detailed understanding of soil hydraulic properties, particularly soil available water content (AWC) within the effective root zone, is needed to optimally schedule irrigation in fields with substantial spatial heterogeneity. However, it is difficult and time consuming to directly measure soil hydraulic properties. Therefore, easily collected and measured soil properties, such as soil texture and/or bulk density, that are well correlated with hydraulic properties are used as proxies to develop pedotransfer functions (PTF). In this study, multiple modeling scenarios were developed and evaluated to indirectly predict high resolution AWC maps within the effective root zone. The modeling techniques included kriging, co-kriging, regression kriging, artificial neural networks (NN) and geographically weighted regression (GWR). The efficiency of soil apparent electrical conductivity (ECa) as proximal data in the modeling process was assessed. There was a good agreement (root mean square error (RMSE) = 0.052 cm3 cm-3 and r = 0.88) between observed and point prediction of water contents using pseudo continuous PTFs. We found that both GWR (mean RMSE = 0.062 cm3 cm-3) and regression kriging (mean RMSE = 0.063 cm3 cm-3) produced the best water content maps with these accuracies improved up to 19% when ECa was used as an ancillary soil attribute in the interpolation process. The maps indicated fourfold differences in AWC between coarse- and fine-textured soils across the study site. This provided a template for future investigations for evaluating the efficiency of variable rate irrigation management scenarios in accounting for the spatial heterogeneity of soil hydraulic attributes.

  11. Terrestrial locomotion imposes high metabolic requirements on bats.

    Science.gov (United States)

    Voigt, Christian C; Borrisov, Ivailo M; Voigt-Heucke, Silke L

    2012-12-15

    The evolution of powered flight involved major morphological changes in Chiroptera. Nevertheless, all bats are also capable of crawling on the ground and some are even skilled sprinters. We asked if a highly derived morphology adapted for flapping flight imposes high metabolic requirements on bats when moving on the ground. We measured the metabolic rate during terrestrial locomotion in mastiff bats, Molossus currentium, a species that is both a fast-flying aerial-hawking bat and an agile crawler on the ground. Metabolic rates of bats averaged 8.0±4.0 ml CO(2) min(-1) during a 1-min period of sprinting at 1.3±0.6 km h(-1). With rising average speed, mean metabolic rates increased, reaching peak values that were similar to those of flying conspecifics. Metabolic rates of M. currentium were higher than those of similar-sized rodents that sprinted at similar velocities under steady-state conditions. When M. currentium sprinted at peak velocities, its aerobic metabolic rate was 3-5 times higher than those of rodent species running continuously in steady-state conditions. Costs of transport (J kg(-1) m(-1)) were more than 10 times higher for running than for flying bats. We conclude that at the same speed bats experience higher metabolic rates during short sprints than quadruped mammals during steady-state terrestrial locomotion, yet running bats achieve higher maximal mass-specific aerobic metabolic rates than non-volant mammals such as rodents.

  12. New Generation Nuclear Plant -- High Level Functions and Requirements

    Energy Technology Data Exchange (ETDEWEB)

    J. M. Ryskamp; E. J. Gorski; E. A. Harvego; S. T. Khericha; G. A. Beitel

    2003-09-01

    This functions and requirements (F&R) document was prepared for the Next Generation Nuclear Plant (NGNP) Project. The highest-level functions and requirements for the NGNP preconceptual design are identified in this document, which establishes performance definitions for what the NGNP will achieve. NGNP designs will be developed based on these requirements by commercial vendor(s).

  13. Design requirements for high-efficiency high concentration ratio space solar cells

    Science.gov (United States)

    Rauschenbach, H.; Patterson, R.

    1980-01-01

    A miniaturized Cassegrainian concentrator system concept was developed for low cost, multikilowatt space solar arrays. The system imposes some requirements on solar cells which are new and different from those imposed for conventional applications. The solar cells require a circular active area of approximately 4 mm in diameter. High reliability contacts are required on both front and back surfaces. The back area must be metallurgically bonded to a heat sink. The cell should be designed to achieve the highest practical efficiency at 100 AMO suns and at 80 C. The cell design must minimize losses due to nonuniform illumination intensity and nonnormal light incidence. The primary radiation concern is the omnidirectional proton environment.

  14. Systematic review of available evidence on 11 high-priced inpatient orphan drugs

    NARCIS (Netherlands)

    T.A. Kanters (Tim A.); C. de Sonneville (Caroline); W.K. Redekop (Ken); L. van Hakkaart-van Roijen (Leona)

    2013-01-01

    markdownabstract__Abstract__ __Background__: Attention for Evidence Based Medicine (EBM) is growing, but evidence for orphan drugs is argued to be limited and inferior. This study systematically reviews the available evidence on clinical effectiveness, costeffectiveness and budget impact for orph

  15. High Energy Physics and Nuclear Physics Network Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Dart, Eli; Bauerdick, Lothar; Bell, Greg; Ciuffo, Leandro; Dasu, Sridhara; Dattoria, Vince; De, Kaushik; Ernst, Michael; Finkelson, Dale; Gottleib, Steven; Gutsche, Oliver; Habib, Salman; Hoeche, Stefan; Hughes-Jones, Richard; Ibarra, Julio; Johnston, William; Kisner, Theodore; Kowalski, Andy; Lauret, Jerome; Luitz, Steffen; Mackenzie, Paul; Maguire, Chales; Metzger, Joe; Monga, Inder; Ng, Cho-Kuen; Nielsen, Jason; Price, Larry; Porter, Jeff; Purschke, Martin; Rai, Gulshan; Roser, Rob; Schram, Malachi; Tull, Craig; Watson, Chip; Zurawski, Jason

    2014-03-02

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the U.S. Department of Energy (DOE) Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. In support of SC programs, ESnet regularly updates and refreshes its understanding of the networking requirements needed by instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 25 years. In August 2013, ESnet and the DOE SC Offices of High Energy Physics (HEP) and Nuclear Physics (NP) organized a review to characterize the networking requirements of the programs funded by the HEP and NP program offices. Several key findings resulted from the review. Among them: 1. The Large Hadron Collider?s ATLAS (A Toroidal LHC Apparatus) and CMS (Compact Muon Solenoid) experiments are adopting remote input/output (I/O) as a core component of their data analysis infrastructure. This will significantly increase their demands on the network from both a reliability perspective and a performance perspective. 2. The Large Hadron Collider (LHC) experiments (particularly ATLAS and CMS) are working to integrate network awareness into the workflow systems that manage the large number of daily analysis jobs (1 million analysis jobs per day for ATLAS), which are an integral part of the experiments. Collaboration with networking organizations such as ESnet, and the consumption of performance data (e.g., from perfSONAR [PERformance Service Oriented Network monitoring Architecture]) are critical to the success of these efforts. 3. The international aspects of HEP and NP collaborations continue to expand. This includes the LHC experiments, the Relativistic Heavy Ion Collider (RHIC) experiments, the Belle II Collaboration, the Large Synoptic Survey Telescope (LSST), and others. The international nature of these collaborations makes them heavily

  16. 77 FR 64183 - Notice of Availability of a Final General Conformity Determination for the California High-Speed...

    Science.gov (United States)

    2012-10-18

    ... California High-Speed Train System Merced to Fresno Section AGENCY: Federal Railroad Administration (FRA... Section of the California High-Speed Train (HST) System on September 18, 2012. FRA is the lead Federal... General Conformity requirements. The California High Speed Rail Authority (Authority), as the...

  17. Favorable cardio-metabolic outcomes following high carbohydrate intake in accordance with the Daniel Fast: A review of available findings

    Directory of Open Access Journals (Sweden)

    Richard Bloomer

    2017-03-01

    Full Text Available The Daniel Fast is a biblically inspired dietary program rich in carbohydrate, most closely resembling a vegan diet but with additional restrictions, including the elimination of processed foods, white flour products, preservatives, additives, sweeteners, caffeine, and alcohol. While no specific requirements are placed on the ingestion of specific percentages of macronutrients, the mean daily carbohydrate intake is by default approximately 60%, while protein and fat intake are 15% and 25%, respectively. Despite a relatively high carbohydrate intake, multiple favorable cardio-metabolic effects are noted when following the plan, in as few as three weeks. This includes improvements in HOMA-IR, which may be at least in part due to the lower glycemic load and high dietary fiber content of the foods consumed. Other notable changes include reductions in systemic inflammation, total and LDL-cholesterol, oxidative stress, blood pressure, and body weight/body fat. Short and moderate-term compliance to the program is excellent-better than most dietary programs, perhaps due to the ad libitum nature of this plan. This paper presents an overview of the Daniel Fast, a carbohydrate-rich dietary program, including relevant findings from both human and animal investigations using this dietary model.

  18. RELIABILITY, AVAILABILITY, AND SERVICEABILITY FOR PETASCALE HIGH-END COMPUTING AND BEYOND

    Energy Technology Data Exchange (ETDEWEB)

    Chokchai " Box" Leangsuksun

    2011-05-31

    Our project is a multi-institutional research effort that adopts interplay of RELIABILITY, AVAILABILITY, and SERVICEABILITY (RAS) aspects for solving resilience issues in highend scientific computing in the next generation of supercomputers. results lie in the following tracks: Failure prediction in a large scale HPC; Investigate reliability issues and mitigation techniques including in GPGPU-based HPC system; HPC resilience runtime & tools.

  19. Characterization of a commercially available large area, high detection efficiency single-photon avalanche diode

    CERN Document Server

    Stipčević, Mario; Ursin, Rupert

    2013-01-01

    We characterize a new commercial, back-illuminated reach-through silicon single-photon avalanche photo diode (SPAD) SAP500 (Laser Components. Inc.), operated in Geiger-mode for purpose of photon counting. We show that for this sensor a significant interplay exists between dark counts, detection efficiency, afterpulsing, excess voltage and operating temperature, sometimes requiring a careful optimization tailored for a specific application. We find that a large flat plateau of sensitive area of about 0.5 mm in diameter, a peak quantum efficiency of 73% at 560 nm and timing precision down to 150 ps FWHM are the main distinguishing characteristics of this SPAD.

  20. Sympathetic Tone Induced by High Acoustic Tempo Requires Fast Respiration.

    Directory of Open Access Journals (Sweden)

    Ken Watanabe

    Full Text Available Many studies have revealed the influences of music, and particularly its tempo, on the autonomic nervous system (ANS and respiration patterns. Since there is the interaction between the ANS and the respiratory system, namely sympatho-respiratory coupling, it is possible that the effect of musical tempo on the ANS is modulated by the respiratory system. Therefore, we investigated the effects of the relationship between musical tempo and respiratory rate on the ANS. Fifty-two healthy people aged 18-35 years participated in this study. Their respiratory rates were controlled by using a silent electronic metronome and they listened to simple drum sounds with a constant tempo. We varied the respiratory rate-acoustic tempo combination. The respiratory rate was controlled at 15 or 20 cycles per minute (CPM and the acoustic tempo was 60 or 80 beats per minute (BPM or the environment was silent. Electrocardiograms and an elastic chest band were used to measure the heart rate and respiratory rate, respectively. The mean heart rate and heart rate variability (HRV were regarded as indices of ANS activity. We observed a significant increase in the mean heart rate and the low (0.04-0.15 Hz to high (0.15-0.40 Hz frequency ratio of HRV, only when the respiratory rate was controlled at 20 CPM and the acoustic tempo was 80 BPM. We suggest that the effect of acoustic tempo on the sympathetic tone is modulated by the respiratory system.

  1. RF/optical shared aperture for high availability wideband communication RF/FSO links

    Energy Technology Data Exchange (ETDEWEB)

    Ruggiero, Anthony J; Pao, Hsueh-yuan; Sargis, Paul

    2014-04-29

    An RF/Optical shared aperture is capable of transmitting and receiving optical signals and RF signals simultaneously. This technology enables compact wide bandwidth communications systems with 100% availability in clear air turbulence, rain and fog. The functions of an optical telescope and an RF reflector antenna are combined into a single compact package by installing an RF feed at either of the focal points of a modified Gregorian telescope.

  2. RF/optical shared aperture for high availability wideband communication RF/FSO links

    Energy Technology Data Exchange (ETDEWEB)

    Ruggiero, Anthony J; Pao, Hsueh-yuan; Sargis, Paul

    2015-03-24

    An RF/Optical shared aperture is capable of transmitting and receiving optical signals and RF signals simultaneously. This technology enables compact wide bandwidth communications systems with 100% availability in clear air turbulence, rain and fog. The functions of an optical telescope and an RF reflector antenna are combined into a single compact package by installing an RF feed at either of the focal points of a modified Gregorian telescope.

  3. B4G local area: high level requirements and system design

    DEFF Research Database (Denmark)

    Mogensen, Preben; Pajukoski, Kari; Raaf, Bernhard

    2012-01-01

    A next generation Beyond 4G (B4G) radio access technology is expected to become available around 2020 in order to cope with the exponential increase of mobile data traffic. In this paper, research motivations and high level requirements for a B4G local area concept are discussed. Our suggestions...... on the design of the B4G system as well as on the choice of its key technology components are also presented....

  4. Investigating Commercially Available Technology for Language Learners in Higher Education within the High Functioning Disability Spectrum

    Science.gov (United States)

    Savvidou, Georgia; Loizides, Fernando

    2016-01-01

    This work presents the assistive use of a combination of technologies in language learning to individuals with high functioning disabilities within a higher education environment. The primary aim of this research is to introduce the initial findings of a pilot exploratory user test which aims to facilitate a better understanding of the suitability…

  5. GBU-X bounding requirements for highly flexible munitions

    Science.gov (United States)

    Bagby, Patrick T.; Shaver, Jonathan; White, Reed; Cafarelli, Sergio; Hébert, Anthony J.

    2017-04-01

    This paper will present the results of an investigation into requirements for existing software and hardware solutions for open digital communication architectures that support weapon subsystem integration. The underlying requirements of such a communication architecture would be to achieve the lowest latency possible at a reasonable cost point with respect to the mission objective of the weapon. The determination of the latency requirements of the open architecture software and hardware were derived through the use of control system and stability margins analyses. Studies were performed on the throughput and latency of different existing communication transport methods. The two architectures that were tested in this study include Data Distribution Service (DDS) and Modular Open Network Architecture (MONARCH). This paper defines what levels of latency can be achieved with current technology and how this capability may translate to future weapons. The requirements moving forward within communications solutions are discussed.

  6. Building a highly available and intrusion tolerant database security and protection system (DSPS)

    Institute of Scientific and Technical Information of China (English)

    蔡亮; 杨小虎; 董金祥

    2003-01-01

    Database Security and Protection System (DSPS) is a security platform for fighting malicious DBMS. The security and performance are critical to DSPS. The authors suggested a key management scheme by combining the server group structure to improve availability and the key distribution structure needed by proactive security. This paper detailed the implementation of proactive security in DSPS. After thorough performance analysis, the authors concluded that the performance difference between the replicated mechanism and proactive mechanism becomes smaller and smaller with increasing number of concurrent connections; and that proactive security is very useful and practical for large, critical applications.

  7. Building a highly available and intrusion tolerant database security and protection system ( DSPS)

    Institute of Scientific and Technical Information of China (English)

    蔡亮; 杨小虎; 董金祥

    2003-01-01

    Database Security and Protection System (DSPS) is a security platform for fighting malicious DBMS. The security and performance are critical to DSPS. The authors suggested a key management scheme by combining the server group structure to improve availability and the key distribution structure needed by proactive security. This paper detailed the implementation of proactive security in DSPS. After thorough performane analysis, the authors concluded that the performance difference between the replicated mechanism and proactive mechanism becomes smaller and smaller with increasing number of concurrent connections ; and that proactive security is very useful and practical for large, critical applications.

  8. Metal availability in a highly contaminated, dredged-sediment disposal site: Field measurements and geochemical modeling

    Energy Technology Data Exchange (ETDEWEB)

    Lions, Julie, E-mail: j.lions@brgm.f [BRGM, 3 Avenue Claude Guillemin, 45060 Orleans Cedex 2 (France); Centre National de Recherche sur les Sites et Sols Pollues, BP 537, 59505 Douai cedex (France); Guerin, Valerie; Bataillard, Philippe [BRGM, 3 Avenue Claude Guillemin, 45060 Orleans Cedex 2 (France); Centre National de Recherche sur les Sites et Sols Pollues, BP 537, 59505 Douai cedex (France); Lee, Jan van der [Mines ParisTech, Centre de Geosciences, 77305 Fontainebleau Cedex (France); Laboudigue, Agnes [Univ Lille Nord de France, F-59000 Lille (France); EMDouai, MPE-GCE, F-59500 Douai (France); Centre National de Recherche sur les Sites et Sols Pollues, BP 537, 59505 Douai cedex (France)

    2010-09-15

    Two complementary approaches were used to characterize arsenic and metal mobilizations from a dredged-sediment disposal site: a detailed field study combined with hydrogeochemical modeling. Contaminants in sediments were found to be mainly present as sulfides subject to oxidation. Secondary phases (carbonates, sulfates, (hydr)oxides) were also observed. Oxidative processes occurred at different rates depending on physicochemical conditions and contaminant contents in the sediment. Two distinct areas were identified on the site, each corresponding to a specific contaminant mobility behavior. In a reducing area, Fe and As were highly soluble and illustrated anoxic behavior. In well-oxygenated material, groundwater was highly contaminated in Zn, Cd and Pb. A third zone in which sediments and groundwater were less contaminated was also characterized. This study enabled us to prioritize remediation work, which should aim to limit infiltration and long-term environmental impact. - A detailed case study of metal behavior in a dredged-sediment disposal site combined with geochemical modeling.

  9. Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling.

    Science.gov (United States)

    Cox, Gregory R; Clark, Sally A; Cox, Amanda J; Halson, Shona L; Hargreaves, Mark; Hawley, John A; Jeacocke, Nikki; Snow, Rodney J; Yeo, Wee Kian; Burke, Louise M

    2010-07-01

    We determined the effects of varying daily carbohydrate intake by providing or withholding carbohydrate during daily training on endurance performance, whole body rates of substrate oxidation, and selected mitochondrial enzymes. Sixteen endurance-trained cyclists or triathletes were pair matched and randomly allocated to either a high-carbohydrate group (High group; n = 8) or an energy-matched low-carbohydrate group (Low group; n = 8) for 28 days. Immediately before study commencement and during the final 5 days, subjects undertook a 5-day test block in which they completed an exercise trial consisting of a 100 min of steady-state cycling (100SS) followed by a 7-kJ/kg time trial on two occasions separated by 72 h. In a counterbalanced design, subjects consumed either water (water trial) or a 10% glucose solution (glucose trial) throughout the exercise trial. A muscle biopsy was taken from the vastus lateralis muscle on day 1 of the first test block, and rates of substrate oxidation were determined throughout 100SS. Training induced a marked increase in maximal citrate synthase activity after the intervention in the High group (27 vs. 34 micromol x g(-1) x min(-1), P < 0.001). Tracer-derived estimates of exogenous glucose oxidation during 100SS in the glucose trial increased from 54.6 to 63.6 g (P < 0.01) in the High group with no change in the Low group. Cycling performance improved by approximately 6% after training. We conclude that altering total daily carbohydrate intake by providing or withholding carbohydrate during daily training in trained athletes results in differences in selected metabolic adaptations to exercise, including the oxidation of exogenous carbohydrate. However, these metabolic changes do not alter the training-induced magnitude of increase in exercise performance.

  10. Fish bones--a highly available calcium source for growing pigs.

    Science.gov (United States)

    Malde, M K; Graff, I E; Siljander-Rasi, H; Venäläinen, E; Julshamn, K; Pedersen, J I; Valaja, J

    2010-10-01

    In general, there is a lack of scientific documentation of nutritional value of marine by-products. The bone fraction from fish has been regarded as waste. Due to the high mineral content of fish bones, this material can be well suitable as a natural calcium source. In the present study, apparent calcium absorption of different fish bone sources was tested using growing pigs. The experimental diets consisted of boiled salmon frames, or salmon, saithe or cod bones treated with enzymes. Calcium carbonate (CaCO(3)) was used as control. The experimental diets were formulated to contain 0.7% total calcium of which the added calcium source to be tested contributed about 71% (study 1) and 86% (study 2). Except for the calcium and phosphorus sources, the animals received similar basal diets. Apparent calcium digestibility coefficient was calculated using yttrium as indicator (both studies) and was based on complete collection of faeces and urine (study 2). The experimental design was parallel and cross-over in study 1 and study 2, respectively. In study 1, piglets getting salmon bone treated with enzymes had significantly higher calcium absorption than piglets getting boiled fish bone or calcium carbonate. Therefore, in the second study only enzymatically treated fish bones were included. The higher calcium absorption from enzymatically treated salmon bone was also found in study 2, but this time not significant. Calcium from boiled salmon bones in study I, and from enzymatically treated saithe and cod bones in study II were absorbed as well as the calcium carbonate control. The results indicate that fish bones may be a useful and well absorbed calcium source. Due to the high mineral content of the bone fraction, salmon bones can be well suitable as a natural calcium and phosphorus source in, for example, food, feed or as supplement.

  11. Response of Streptococcus suis to iron-restricted growth conditions at high and low oxygen availability.

    Science.gov (United States)

    Winterhoff, Nora; Goethe, Ralph; Gruening, Petra; Valentin-Weigand, Peter

    2004-01-01

    Streptococcus suis (S. suis) is an important pathogen in pigs and has to overcome strict iron limitations in its host environment. Here, we studied iron-restricted growth of a highly virulent S. suis strain in vitro at aerobic and CO2-enriched growth conditions. At both conditions, depleting of iron in the culture medium with nitrilotriacetic acid (NTA) resulted in decreased growth rates and down regulation of several proteins. Sensitivity to NTA was significantly higher at aerobic versus CO2-enriched conditions. Growth could not be restored by addition of host iron sources such as ferritin, hemin, hemoglobin, lactoferrin or transferrin. Accordingly, S. suis was not able to produce detectable amounts of siderophores. On the other hand, growth at iron-restricted conditions was fully restored by addition of Mn2+ (at aerobic and CO2-enriched conditions) or Mg2+ (only at CO2-enriched conditions). In conclusion our results suggest that, unlike many other bacteria, S. suis adapts to iron restricted conditions by a change in its metabolism in order to replace Fe2+ by Mn2+ or Mg2+ rather than by expressing specific iron uptake systems.

  12. Using DNA metabarcoding to investigate honey bee foraging reveals limited flower use despite high floral availability.

    Science.gov (United States)

    de Vere, Natasha; Jones, Laura E; Gilmore, Tegan; Moscrop, Jake; Lowe, Abigail; Smith, Dan; Hegarty, Matthew J; Creer, Simon; Ford, Col R

    2017-02-16

    Understanding which flowers honey bees (Apis mellifera) use for forage can help us to provide suitable plants for healthy honey bee colonies. Accordingly, honey DNA metabarcoding provides a valuable tool for investigating pollen and nectar collection. We investigated early season (April and May) floral choice by honey bees provided with a very high diversity of flowering plants within the National Botanic Garden of Wales. There was a close correspondence between the phenology of flowering and the detection of plants within the honey. Within the study area there were 437 genera of plants in flower during April and May, but only 11% of these were used. Thirty-nine plant taxa were recorded from three hives but only ten at greater than 1%. All three colonies used the same core set of native or near-native plants, typically found in hedgerows and woodlands. The major plants were supplemented with a range of horticultural species, with more variation in plant choice between the honey bee colonies. We conclude that during the spring, honey bees need access to native hedgerows and woodlands to provide major plants for foraging. Gardens provide supplementary flowers that may increase the nutritional diversity of the honey bee diet.

  13. Detection of high-risk human papillomavirus infection in tonsillar specimens using 2 commercially available assays.

    Science.gov (United States)

    Cockerill, Cara C; Orvidas, Laura J; Moore, Eric J; Binnicker, Matthew J; Duresko, Brian J; Espy, Mark J; Cockerill, Franklin R; Tombers, Nicole M; Pritt, Bobbi S

    2016-12-01

    THE OBJECTIVE OF THE STUDY IS TO DETERMINE THE PREVALENCE OF HIGH-RISK HUMAN PAPILLOMAVIRUS (HRHPV) INFECTION IN TONSILLAR SWABS AND TISSUE: Patients undergoing tonsillectomy for nonmalignant causes were enrolled. A flocked swab and fresh tissue were collected from the left and right tonsil of each patient. Specimens were tested for hrHPV DNA using the Roche cobas test and for the presence of E6/E7 messenger RNA using the Hologic Aptima hrHPV test. Of the 193 patients enrolled, 129 were in the pediatric group (ages 1-12years; median, 5years), and 64 were in the adult group (ages 13-55; median, 22years). All swab and tissue specimens were negative for hrHPV by both methods. Positive, negative, and internal controls performed as expected. We found a 0% rate of infection indicating that detectable hrHPV infection in tonsillar tissue appears to be uncommon in the children and adults in the population sampled. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Using DNA metabarcoding to investigate honey bee foraging reveals limited flower use despite high floral availability

    Science.gov (United States)

    de Vere, Natasha; Jones, Laura E.; Gilmore, Tegan; Moscrop, Jake; Lowe, Abigail; Smith, Dan; Hegarty, Matthew J.; Creer, Simon; Ford, Col R.

    2017-01-01

    Understanding which flowers honey bees (Apis mellifera) use for forage can help us to provide suitable plants for healthy honey bee colonies. Accordingly, honey DNA metabarcoding provides a valuable tool for investigating pollen and nectar collection. We investigated early season (April and May) floral choice by honey bees provided with a very high diversity of flowering plants within the National Botanic Garden of Wales. There was a close correspondence between the phenology of flowering and the detection of plants within the honey. Within the study area there were 437 genera of plants in flower during April and May, but only 11% of these were used. Thirty-nine plant taxa were recorded from three hives but only ten at greater than 1%. All three colonies used the same core set of native or near-native plants, typically found in hedgerows and woodlands. The major plants were supplemented with a range of horticultural species, with more variation in plant choice between the honey bee colonies. We conclude that during the spring, honey bees need access to native hedgerows and woodlands to provide major plants for foraging. Gardens provide supplementary flowers that may increase the nutritional diversity of the honey bee diet. PMID:28205632

  15. Cielo Computational Environment Usage Model With Mappings to ACE Requirements for the General Availability User Environment Capabilities Release Version 1.1

    Energy Technology Data Exchange (ETDEWEB)

    Vigil,Benny Manuel [Los Alamos National Laboratory; Ballance, Robert [SNL; Haskell, Karen [SNL

    2012-08-09

    Cielo is a massively parallel supercomputer funded by the DOE/NNSA Advanced Simulation and Computing (ASC) program, and operated by the Alliance for Computing at Extreme Scale (ACES), a partnership between Los Alamos National Laboratory (LANL) and Sandia National Laboratories (SNL). The primary Cielo compute platform is physically located at Los Alamos National Laboratory. This Cielo Computational Environment Usage Model documents the capabilities and the environment to be provided for the Q1 FY12 Level 2 Cielo Capability Computing (CCC) Platform Production Readiness Milestone. This document describes specific capabilities, tools, and procedures to support both local and remote users. The model is focused on the needs of the ASC user working in the secure computing environments at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory, or Sandia National Laboratories, but also addresses the needs of users working in the unclassified environment. The Cielo Computational Environment Usage Model maps the provided capabilities to the tri-Lab ASC Computing Environment (ACE) Version 8.0 requirements. The ACE requirements reflect the high performance computing requirements for the Production Readiness Milestone user environment capabilities of the ASC community. A description of ACE requirements met, and those requirements that are not met, are included in each section of this document. The Cielo Computing Environment, along with the ACE mappings, has been issued and reviewed throughout the tri-Lab community.

  16. Single High Fidelity Geometric Data Sets for LCM - Model Requirements

    Science.gov (United States)

    2006-11-01

    material name (example, an HY80 steel ) plus additional material requirements (heat treatment, etc.) Creation of a more detailed description of the data...57 Figure 2.22. Typical Stress-Strain Curve for Steel (adapted from Ref 59) .............................. 60 Figure...structures are steel , aluminum and composites. The structural components that make up a global FEA model drive the fidelity of the model. For example

  17. High School Physics Availability: Results from the 2008-09 Nationwide Survey of High School Physics Teachers. Focus On

    Science.gov (United States)

    White, Susan; Tesfaye, Casey Langer

    2010-01-01

    In the fall of 2008, the authors contacted a representative sample of over 3,600 high schools in the U.S.--both public and private--to determine whether or not physics was taught there. They received responses from over 99% of the schools. For the schools which indicated they were offering physics, they obtained contact information for the…

  18. Cassandra high availability

    CERN Document Server

    Strickland, Robbie

    2014-01-01

    If you are a developer or DevOps engineer who understands the basics of Cassandra and are ready to take your knowledge to the next level, then this book is for you. An understanding of the essentials of Cassandra is needed.

  19. Implementation and use of a highly available and innovative IaaS solution: the Cloud Area Padovana

    Science.gov (United States)

    Aiftimiei, C.; Andreetto, P.; Bertocco, S.; Biasotto, M.; Dal Pra, S.; Costa, F.; Crescente, A.; Dorigo, A.; Fantinel, S.; Fanzago, F.; Frizziero, E.; Gulmini, M.; Michelotto, M.; Sgaravatto, M.; Traldi, S.; Venaruzzo, M.; Verlato, M.; Zangrando, L.

    2015-12-01

    While in the business world the cloud paradigm is typically implemented purchasing resources and services from third party providers (e.g. Amazon), in the scientific environment there's usually the need of on-premises IaaS infrastructures which allow efficient usage of the hardware distributed among (and owned by) different scientific administrative domains. In addition, the requirement of open source adoption has led to the choice of products like OpenStack by many organizations. We describe a use case of the Italian National Institute for Nuclear Physics (INFN) which resulted in the implementation of a unique cloud service, called ’Cloud Area Padovana’, which encompasses resources spread over two different sites: the INFN Legnaro National Laboratories and the INFN Padova division. We describe how this IaaS has been implemented, which technologies have been adopted and how services have been configured in high-availability (HA) mode. We also discuss how identity and authorization management were implemented, adopting a widely accepted standard architecture based on SAML2 and OpenID: by leveraging the versatility of those standards the integration with authentication federations like IDEM was implemented. We also discuss some other innovative developments, such as a pluggable scheduler, implemented as an extension of the native OpenStack scheduler, which allows the allocation of resources according to a fair-share based model and which provides a persistent queuing mechanism for handling user requests that can not be immediately served. Tools, technologies, procedures used to install, configure, monitor, operate this cloud service are also discussed. Finally we present some examples that show how this IaaS infrastructure is being used.

  20. Superconductor Requirements and Characterization for High Field Accelerator Magnets

    Energy Technology Data Exchange (ETDEWEB)

    Barzi, E.; Zlobin, A. V.

    2015-05-01

    The 2014 Particle Physics Project Prioritization Panel (P5) strategic plan for U.S. High Energy Physics (HEP) endorses a continued world leadership role in superconducting magnet technology for future Energy Frontier Programs. This includes 10 to 15 T Nb3Sn accelerator magnets for LHC upgrades and a future 100 TeV scale pp collider, and as ultimate goal that of developing magnet technologies above 20 T based on both High Temperature Superconductors (HTS) and Low Temperature Superconductors (LTS) for accelerator magnets. To achieve these objectives, a sound conductor development and characterization program is needed and is herein described. This program is intended to be conducted in close collaboration with U.S. and International labs, Universities and Industry.

  1. Shear Reinforcement Requirements for High-Strength Concrete Bridge Girders

    OpenAIRE

    Ramirez, J. A.; Aguilar, Gerardo

    2005-01-01

    A research program was conducted on the shear strength of high-strength concrete members. The objective was to evaluate the shear behavior and strength of concrete bridge members with compressive strengths in the range of 10 000 to 15 000 psi. The goal was to determine if the current minimum amount of shear reinforcement together with maximum spacing limits in the 2004 AASHTO LRFD Specifications, and the upper limit on the nominal shear strength were applicable to concrete compressive strengt...

  2. High efficiency of collisional Penrose process requires heavy particle production

    CERN Document Server

    Ogasawara, Kota; Miyamoto, Umpei

    2015-01-01

    The center-of-mass energy of two particles can become arbitrarily large if they collide near the event horizon of an extremal Kerr black hole, which is called the Ba$\\rm \\tilde n$ados-Silk-West (BSW) effect. We consider such a high-energy collision of two particles which started from infinity and follow geodesics in the equatorial plane and investigate the energy extraction from such a high-energy particle collision and the production of particles in the equatorial plane. We analytically show that, on the one hand, if the produced particles are as massive as the colliding particles, the energy-extraction efficiency is bounded by $2.19$ approximately. On the other hand, if a very massive particle is to be produced as a result of the high-energy collision, which has negative energy and necessarily falls into the black hole, the upper limit of the energy-extraction efficiency is increased to $(2+\\sqrt{3})^2 \\simeq 13.9$. Thus, higher efficiency of the energy extraction, which is typically as large as 10, provide...

  3. An Exploration of Support Factors Available to Higher Education Students with High Functioning Autism or Asperger Syndrome

    Science.gov (United States)

    Rutherford, Emily N.

    2013-01-01

    This qualitative phenomenological research study used narrative inquiry to explore the support factors available to students with High Functioning Autism or Asperger Syndrome in higher education that contribute to their success as perceived by the students. Creswell's (2009) six step method for analyzing phenomenological studies was used to…

  4. An Exploration of Support Factors Available to Higher Education Students with High Functioning Autism or Asperger Syndrome

    Science.gov (United States)

    Rutherford, Emily N.

    2013-01-01

    This qualitative phenomenological research study used narrative inquiry to explore the support factors available to students with High Functioning Autism or Asperger Syndrome in higher education that contribute to their success as perceived by the students. Creswell's (2009) six step method for analyzing phenomenological studies was used to…

  5. The Availability and Utilization of School Library Resources in Some Selected Secondary Schools (High School) in Rivers State

    Science.gov (United States)

    Owate, C. N.; Iroha, Okpa

    2013-01-01

    This study investigates the availability and utilization of school library resources by Secondary School (High School) Students. Eight Selected Secondary Schools in Rivers State, Nigeria were chosen based on their performance in external examinations and geographic locations. In carrying out the research, questionnaires were administered to both…

  6. Improvement of availability of PWR nuclear plants through the reduction of the time required for refueling/maintenance outages, Phase 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, C.A.

    1978-08-01

    The objective of this project is to identify improvements in procedures and equipment which will reduce the time required for refueling/maintenance outages at PWR nuclear power plants. The outage of Commonwealth Edison Zion Station Unit 1 in March through May of 1976 was evaluated to identify those items which caused delays and those work activities that offer the potential for significant improvements toward reducing its overall duration. Thus, the plant's availability for power production would be increased. Revisions in procedures and some equipment modifications were implemented and evaluated during the Zion Unit 2 refueling/maintenance outage beginning in January 1977. Analysis of the observed data has identified benefits available through improved refueling equipment and also areas where additional new, innovative refueling, or refueling-related equipment should be beneficial. A number of specific design concepts are recommended as a result of Phase 1. In addition, a new master planning mechanism is described for implementation during subsequent planned outages at Zion Station. This final report describes the recommended conceptual designs and planning mechanism and assesses their impact upon future outages. Their effect on savings in refueling time, labor, and radiation exposure is discussed. The estimated economic payoff for these concepts was found to be of such significance that an additional phase of the program is warranted. During this extended phase, a more detailed engineering study should be undertaken to determine the cost of implementation along with more specific estimates of the benefits for PWR plants already in operation or under construction.

  7. Increased insulin requirements during exercise at very high altitude in type 1 diabetes

    NARCIS (Netherlands)

    de Mol, Pieter; de Vries, Suzanna T.; de Koning, Eelco J. P.; Gans, Rijk O. B.; Tack, Cees J.; Bilo, Henk J. G.

    2011-01-01

    OBJECTIVE-Safe, very high altitude trekking in subjects with type 1 diabetes requires understanding of glucose regulation at high altitude. We investigated insulin requirements, energy expenditure, and glucose levels at very high altitude in relation to acute mountain sickness (AMS) symptoms in indi

  8. Increased insulin requirements during exercise at very high altitude in type 1 diabetes

    NARCIS (Netherlands)

    Mol, P. De; Vries, S.T. de; Koning, E.J. de; Gans, R.O.; Tack, C.J.J.; Bilo, H.J.

    2011-01-01

    OBJECTIVE: Safe, very high altitude trekking in subjects with type 1 diabetes requires understanding of glucose regulation at high altitude. We investigated insulin requirements, energy expenditure, and glucose levels at very high altitude in relation to acute mountain sickness (AMS) symptoms in ind

  9. Increased insulin requirements during exercise at very high altitude in type 1 diabetes

    NARCIS (Netherlands)

    Mol, P. De; Vries, S.T. de; Koning, E.J. de; Gans, R.O.; Tack, C.J.J.; Bilo, H.J.

    2011-01-01

    OBJECTIVE: Safe, very high altitude trekking in subjects with type 1 diabetes requires understanding of glucose regulation at high altitude. We investigated insulin requirements, energy expenditure, and glucose levels at very high altitude in relation to acute mountain sickness (AMS) symptoms in

  10. Increased insulin requirements during exercise at very high altitude in type 1 diabetes

    NARCIS (Netherlands)

    de Mol, Pieter; de Vries, Suzanna T.; de Koning, Eelco J. P.; Gans, Rijk O. B.; Tack, Cees J.; Bilo, Henk J. G.

    OBJECTIVE-Safe, very high altitude trekking in subjects with type 1 diabetes requires understanding of glucose regulation at high altitude. We investigated insulin requirements, energy expenditure, and glucose levels at very high altitude in relation to acute mountain sickness (AMS) symptoms in

  11. High resolution weather data for urban hydrological modelling and impact assessment, ICT requirements and future challenges

    Science.gov (United States)

    ten Veldhuis, Marie-claire; van Riemsdijk, Birna

    2013-04-01

    Hydrological analysis of urban catchments requires high resolution rainfall and catchment information because of the small size of these catchments, high spatial variability of the urban fabric, fast runoff processes and related short response times. Rainfall information available from traditional radar and rain gauge networks does no not meet the relevant scales of urban hydrology. A new type of weather radars, based on X-band frequency and equipped with Doppler and dual polarimetry capabilities, promises to provide more accurate rainfall estimates at the spatial and temporal scales that are required for urban hydrological analysis. Recently, the RAINGAIN project was started to analyse the applicability of this new type of radars in the context of urban hydrological modelling. In this project, meteorologists and hydrologists work closely together in several stages of urban hydrological analysis: from the acquisition procedure of novel and high-end radar products to data acquisition and processing, rainfall data retrieval, hydrological event analysis and forecasting. The project comprises of four pilot locations with various characteristics of weather radar equipment, ground stations, urban hydrological systems, modelling approaches and requirements. Access to data processing and modelling software is handled in different ways in the pilots, depending on ownership and user context. Sharing of data and software among pilots and with the outside world is an ongoing topic of discussion. The availability of high resolution weather data augments requirements with respect to the resolution of hydrological models and input data. This has led to the development of fully distributed hydrological models, the implementation of which remains limited by the unavailability of hydrological input data. On the other hand, if models are to be used in flood forecasting, hydrological models need to be computationally efficient to enable fast responses to extreme event conditions. This

  12. Availability and Quality of Family Planning Services in the Democratic Republic of the Congo: High Potential for Improvement.

    Science.gov (United States)

    Mpunga, Dieudonné; Lumbayi, J P; Dikamba, Nelly; Mwembo, Albert; Ali Mapatano, Mala; Wembodinga, Gilbert

    2017-06-27

    To determine the availability and quality of family planning services within health facilities throughout the Democratic Republic of the Congo (DRC). Data were collected for the cross-sectional study from April 2014 to June 2014 by the Ministry of Public Health. A total of 1,568 health facilities that reported data to the National Health Information System were selected by multistage random sampling in the 11 provinces of the DRC existing at that time. Data were collected through interviews, document review, and direct observation. Two dependent variables were measured: availability of family planning services (consisting of a room for services, staff assigned to family planning, and evidence of client use of family planning) and quality of family planning services (assessed as "high" if the facility had at least 1 trained staff member, family planning service delivery guidelines, at least 3 types of methods, and a sphygmomanometer, or "low" if the facility did not meet any of these 4 criteria). Pearson's chi-square test and odds ratios (ORs) were used to test for significant associations, using the alpha significance level of .05. We successfully surveyed 1,555 facilities (99.2%) of those included in the sample. One in every 3 facilities (33%) offered family planning services as assessed by the index of availability, of which 20% met all 4 criteria for providing high-quality services. Availability was greatest at the highest level of the health system (hospitals) and decreased incrementally with each health system level, with disparities between provinces and urban and rural areas. Facilities in urban areas were more likely than in rural areas to meet the standard for high-quality services (Pplanning services in health facilities in the DRC remain low, with inequitable distribution of services throughout the country. To improve access to and use of family planning, efforts should focus on improving availability and quality at lower health system levels and in

  13. Availability of state-based obesity surveillance data on high school students with disabilities in the United States.

    Science.gov (United States)

    Yamaki, Kiyoshi; Lowry, Brienne Davis; Buscaj, Emilie; Zisko, Leigh; Rimmer, James H

    2015-05-01

    The aim of this study was to assess the availability of public health surveillance data on obesity among American children with disabilities in state-based surveillance programs. We reviewed annual cross-sectional datasets in state-level surveillance programs for high school students, implemented 2001-2011, for the inclusion of weight and height and disability screening questions. When datasets included a disability screen, its content and consistency of use across years were examined. We identified 54 surveillance programs with 261 annual datasets containing obesity data. Twelve surveillance programs in 11 states included a disability screening question that could be used to extract obesity data for high school students with disabilities, leaving the other 39 states with no state-level obesity data for students with disabilities. A total of 43 annual datasets, 16.5 % of the available datasets, could be used to estimate the obesity status of students with disabilities. The frequency of use of disability questions varied across states, and the content of the questions often changed across years and within a state. We concluded that state surveillance programs rarely contained questions that could be used to identify high school students with disabilities. This limits the availability of data that can be used to monitor obesity and related health statuses among this population in the majority of states.

  14. Condom availability in high risk places and condom use: a study at district level in Kenya, Tanzania and Zambia

    Directory of Open Access Journals (Sweden)

    Sandøy Ingvild

    2012-11-01

    Full Text Available Abstract Background A number of studies from countries with severe HIV epidemics have found gaps in condom availability, even in places where there is a substantial potential for HIV transmission. Although reported condom use has increased in many African countries, there are often big differences by socioeconomic background. The aim of this study was to assess equity aspects of condom availability and uptake in three African districts to evaluate whether condom programmes are given sufficient priority. Methods Data on condom availability and use was examined in one district in Kenya, one in Tanzania and one in Zambia. The study was based on a triangulation of data collection methods in the three study districts: surveys in venues where people meet new sexual partners, population-based surveys and focus group discussions. The data was collected within an overall study on priority setting in health systems. Results At the time of the survey, condoms were observed in less than half of the high risk venues in two of the three districts and in 60% in the third district. Rural respondents in the population-based surveys perceived condoms to be less available and tended to be less likely to report condom use than urban respondents. Although focus group participants reported that condoms were largely available in their district, they expressed concerns related to the accessibility of free condoms. Conclusion As late as thirty years into the HIV epidemic there are still important gaps in the availability of condoms in places where people meet new sexual partners in these three African districts. Considering that previous studies have found that improved condom availability and accessibility in high risk places have a potential to increase condom use among people with multiple partners, the present study findings indicate that substantial further efforts should be made to secure that condoms are easily accessible in places where sexual relationships are

  15. Computer Science in High School Graduation Requirements. ECS Education Trends (Updated)

    Science.gov (United States)

    Zinth, Jennifer

    2016-01-01

    Allowing high school students to fulfill a math or science high school graduation requirement via a computer science credit may encourage more student to pursue computer science coursework. This Education Trends report is an update to the original report released in April 2015 and explores state policies that allow or require districts to apply…

  16. THE ASSESMENT OF MAIN CHARACTERISTICS AND PROCESSING AVAILABILITY OF WOOL OBTAINED FROM SHEEP BELONGING TO THE PALAS HIGH PROLIFICACY LINE

    Directory of Open Access Journals (Sweden)

    ANA ENCIU

    2013-12-01

    Full Text Available The purpose of these researches was to analyze the quantitative and qualitative parameters of wool obtained from the Palas sheep population with high prolificacy and to assess the processing availabilities of these fibres type. Average values recorded for the main wool traits ranged between the following limits: wool production 2.86 ÷ 4.72 kilos; fibres fineness 27.28 ÷ 29.32 microns; variability of fineness ( CV 26.88 ÷ 29.94 %; staple length 9.77 ÷ 14.23 cm, variability of length ( CV 18.01 ÷ 22.06 % ; scouring yield 54.05 ÷ 61.44 % and the variability of yield 8.35 ÷ 14.78 %. . This wool has a technological value similar to that obtained from the sheep breed with medium fineness wool (Tigaie, Spanca .

  17. Places available **

    CERN Multimedia

    2003-01-01

    Des places sont disponibles dans les cours suivants : Places are available in the following courses : Introduction à Windows 2000 au CERN : 25.2.03 (1/2 journée) LabView base 2/LabView Basics 2 : 10 & 11.3.03 (2 jours/2 days) langue à définir/Language to be decided C++ for Particle Physicists : 10 - 14.3.03 (6 X 3-hour lectures) Introduction to PVSS : 10.3.03 (half day, afternoon) Basic PVSS : 11 - 13.3.03 (3 days) LabView avancé /LabView Advanced : 12 - 14.3.03 (3 jours/3days) Langue à définir/Language to be decided AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 17, 18, 24 & 25.3.03 (6 jours) PVSS - JCOP Framework Tutorial : 14.3.03 (1 day) CLEAN-2002 : Working in a cleanroom : 2.4.03 (half-day, afternoon, free course, registration required) LabView base 1/LabView Basics 1 : 9 - 11.4.03 (3 jours/3 days) Langue à définir/Language to be decided DISP-2003 - Spring II Term : Advanced Digital Signal Processing : 30.4, 7, 14, 21.5.03 (4 X 2-hour lectures) AutoCAD 2002 - niveau 2 : 5 & 6.5.03 (...

  18. Places available **

    CERN Document Server

    2003-01-01

    Des places sont disponibles dans les cours suivants : Places are available in the following course : Introduction to the CERN Engineering Data Management System : 28.1.03 (1 day) AutoCAD 2002 - niveau 1 : 24, 25.2 et 3, 4.3.03 (4 jours) AutoCAD 2002 - niveau 2 : 27 & 28.2.03 (2 jours) C++ for Particle Physicists : 10 - 14.3.03 (6 X 3 hour lectures) AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 17, 18, 24 & 25.3.03 (6 jours) CLEAN-2002 : Working in a cleanroom : 25.3.03 (half-day, afternoon, free course, registration required) Formation Siemens SIMATIC /Siemens SIMATIC Training : Introduction à STEP7 /Introduction to STEP7 : 11 & 12.3.03 / 3 & 4.6.03 (2 jours/2 days) Programmation STEP7/STEP7 Programming : 31.3 - 4.4.03 / 16 - 20.6.03 (5 jours/5 days) Réseau Simatic Net /Simatic Net Network : 15 & 16.4.03 / 26 & 27.6.03 Ces cours seront donnés en français ou anglais en fonction des demandes / These courses will be given in French or English following the requests. * Etant do...

  19. Places available **

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : CLEAN-2002 : Working in a cleanroom (free course, registration required): 11.4.03 (half-day, afternoon, ) LabView Basics 2 : 10 - 11.4.03 (3 days) DISP-2003 - Spring II Term : Advanced Digital Signal Processing : 30.4, 7, 14, 21.5.03 (4 X 2-hour lectures) AutoCAD 2002 - niveau 1 : 29, 30.4 et 7, 8.5.03 (4 jours) Oracle iDS Reports : Build Internet Reports : 5 - 9.5.03 (5 days) AutoCAD 2002 - niveau 2 : 5 & 6.5.03 (2 jours) AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 20, 21, 27 & 28.5.03 (6 jours) Formation Siemens SIMATIC /Siemens SIMATIC Training : Introduction à STEP7 /Introduction to STEP7 : 3 & 4.6.03 (2 jours/2 days) Programmation STEP7/STEP7 Programming : 31.3 - 4.4.03 / 16 - 20.6.03 (5 jours/5 days) Réseau Simatic Net /Simatic Net Network : 15 & 16.4.03 / 26 & 27.6.03 These courses will be given in French or English following the requests. Cours de sécurité : Etre TSO au CERN : Prochaines sessions : 24, 25 & 27.6....

  20. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : CLEAN-2002 : Working in a cleanroom (free course, registration required): 11.4.03 (half-day, afternoon, ) LabView Basics 2 : 10 - 11.4.03 (3 days) DISP-2003 - Spring II Term : Advanced Digital Signal Processing : 30.4, 7, 14, 21.5.03 (4 X 2-hour lectures) AutoCAD 2002 - niveau 1 : 29, 30.4 et 7, 8.5.03 (4 jours) Oracle iDS Reports : Build Internet Reports : 5 - 9.5.03 (5 days) AutoCAD 2002 - niveau 2 : 5 & 6.5.03 (2 jours) AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 20, 21, 27 & 28.5.03(6 jours) Formation Siemens SIMATIC /Siemens SIMATIC Training : Introduction à STEP7 /Introduction to STEP7 : 3 & 4.6.03 (2 jours/2 days) Programmation STEP7/STEP7 Programming : 31.3 - 4.4.03 / 16 - 20.6.03 (5 jours/5 days) Réseau Simatic Net /Simatic Net Network : 15 & 16.4.03 / 26 & 27.6.03 These courses will be given in French or English following the requests. Cours de sécurité : Etre TSO au CERN : Prochaines sessions : 24, 25 & 27.6...

  1. Places available **

    CERN Multimedia

    2003-01-01

    Des places sont disponibles dans les cours suivants : Places are available in the following courses : C++ for Particle Physicists : 10 - 14.3.03 (6 X 3-hour lectures) Introduction to PVSS : 10.3.03 (half day, afternoon) Basic PVSS : 11 - 13.3.03 (3 days) PVSS - JCOP Framework Tutorial : 14.3.03 (1 day) CLEAN-2002 : Working in a cleanroom : 2.4.03 (half-day, afternoon, free course, registration required) LabView base 1/LabView Basics 1 : 9 - 11.4.03 (3 jours/3 days) Langue à définir/language to be decided DISP-2003 - Spring II Term : Advanced Digital Signal Processing : 30.4, 7, 14, 21.5.03 (4 X 2-hour lectures) AutoCAD 2002 - niveau 1 : 29, 30.4 et 7, 8.5.03 (4 jours) AutoCAD 2002 - niveau 2 : 5 & 6.5.03 (2 jours) AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 20, 21, 27 & 28.5.03 (6 jours) Formation Siemens SIMATIC /Siemens SIMATIC Training : Introduction à STEP7 /Introduction to STEP7 : 11 & 12.3.03 / 3 & 4.6.03 (2 jours/2 days) Programmation STEP7/STEP7 Programming : 31.3 - 4.4.03 / 16...

  2. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : Introduction to PVSS : 10.3.03 (half-day, afternoon) CLEAN-2002 : Working in a cleanroom : 2.4.03 (half-day, afternoon, free course, registration required) LabView Basics 1 : 9 - 11.4.03 (3 days) Language to be decided. DISP-2003 - Spring II Term : Advanced Digital Signal Processing : 30.4, 7, 14, 21.5.03 (4 X 2-hour lectures). AutoCAD 2002 - niveau 1 : 29, 30.4 et 7, 8.5.03 (4 jours) AutoCAD 2002 - niveau 2 : 5 & 6.5.03 (2 jours) AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 20, 21, 27 & 28.5.03 (6 jours) Siemens SIMATIC Training: Introduction to STEP7 : 3 & 4.6.03 (2 days) STEP7 Programming : 31.3 - 4.4.03 / 16 - 20.6.03 (5 days) Simatic Net Network : 15 & 16.4.03 / 26 & 27.6.03 These courses will be given in French or English following the requests. Cours de sécurité: Etre TSO au CERN : 3 sessions sont programmées pour 2003 : 25, 26 & 28.3.03 - 24, 25 & 27.6.03 - 4, 5 & 7.11.03 (sessions de 3 jours) ** The number o...

  3. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : CLEAN-2002 : Working in a cleanroom (free course, registration required) : 2.4.03 (half-day, afternoon) LabView base 1/LabView Basics 1 (Langue à définir/ language to be decided) : 9 - 11.4.03 (3 jours/3 days) DISP-2003 - Spring II Term : Advanced Digital Signal Processing : 30.4, 7, 14, 21.5.03 (4 X 2-hour lectures) AutoCAD 2002 - niveau 1 : 29, 30.4 et 7, 8.5.03 (4 jours) AutoCAD 2002 - niveau 2 : 5 & 6.5.03 (2 jours) AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 20, 21, 27 & 28.5.03(6 jours) Formation Siemens SIMATIC /Siemens SIMATIC Training : Introduction à STEP7 /Introduction to STEP7 : 3 & 4.6.03 (2 jours/2 days) Programmation STEP7/STEP7 Programming : 31.3 - 4.4.03 / 16 - 20.6.03 (5 jours/5 days) Réseau Simatic Net /Simatic Net Network : 15 & 16.4.03 / 26 & 27.6.03 These courses will be given in French or English following the requests. Cours de sécurité : Etre TSO au CERN : 3 sessions sont programmées pour 2003 : 25...

  4. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : CLEAN-2002 : Working in a cleanroom (free course, registration required): 11.4.03 (half-day, afternoon) LabView Basics 2 : 10 - 11.4.03 (3 days) DISP-2003 - Spring II Term : Advanced Digital Signal Processing : 30.4, 7, 14, 21.5.03 (4 X 2-hour lectures) AutoCAD 2002 - niveau 1 : 29, 30.4 et 7, 8.5.03 (4 jours) Oracle iDS Reports : Build Internet Reports : 5 - 9.5.03 (5 days) AutoCAD 2002 - niveau 2 : 5 & 6.5.03 (2 jours) AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 20, 21, 27 & 28.5.03(6 jours) Formation Siemens SIMATIC /Siemens SIMATIC Training : Introduction à STEP7 /Introduction to STEP7 : 3 & 4.6.03 (2 jours/2 days) Programmation STEP7/STEP7 Programming : 16 - 20.6.03 (5 jours/5 days) Réseau Simatic Net /Simatic Net Network : 15 & 16.4.03 / 26 & 27.6.03 These courses will be given in French or English following the requests. Cours de sécurité : Etre TSO au CERN : Prochaines sessions : 24, 25 & 27.6.03 - 4, 5 & 7....

  5. 30 CFR 77.804 - High-voltage trailing cables; minimum design requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage trailing cables; minimum design... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.804 High-voltage trailing cables; minimum design requirements. (a) High-voltage trailing cables used in resistance grounded systems shall...

  6. High Availability Cluster of Linux Based on DRBD%基于DRBD的Linux高可用集群

    Institute of Scientific and Technical Information of China (English)

    巩天宁; 周书明

    2012-01-01

    Analyzing traditional high availability cluster,designing a project based on free open-source software heartbeat and DRBD to solve traditional HA-cluster's deficiency on cost,using heartbeat to construct high availability cluster,using DRBD to synchronize data between cluster's nodes,constructing and testing an FTP HA-cluster based on this design,giving an resolution to brain-split.%文章分析了传统高可用性集群,针对其成本较高的缺点提出了使用免费开源软件heartbeat构造高可用集群、DR BD在集群节点之间同步数据以取代共享磁盘的方案,并设计使用该方案构建高可用FTP集群的实例,通过测试确认该方案的可行性,最后给出集群脑裂的解决方法。

  7. Improved virus removal by high-basicity polyaluminum coagulants compared to commercially available aluminum-based coagulants.

    Science.gov (United States)

    Shirasaki, N; Matsushita, T; Matsui, Y; Oshiba, A; Marubayashi, T; Sato, S

    2014-01-01

    We investigated the effects of basicity, sulfate content, and aluminum hydrolyte species on the ability of polyaluminum chloride (PACl) coagulants to remove F-specific RNA bacteriophages from river water at a pH range of 6-8. An increase in PACl basicity from 1.5 to 2.1 and the absence of sulfate led to a reduction of the amount of monomeric aluminum species (i.e., an increase of the total amount of polymeric aluminum and colloidal aluminum species) in the PACl, to an increase in the colloid charge density of the PACl, or to both and, as a result, to high virus removal efficiency. The efficiency of virus removal at around pH 8 observed with PACl-2.1c, a nonsulfated high-basicity PACl (basicity 2.1-2.2) with a high colloidal aluminum content, was larger than that observed with PACl-2.1b, a nonsulfated high-basicity PACl (basicity 2.1-2.2) with a high polymeric aluminum content. In contrast, although extremely high basicity PACls (e.g., PACl-2.7ns, basicity 2.7) effectively removed turbidity and UV260-absorbing natural organic matter and resulted in a very low residual aluminum concentration, the virus removal ratio with PACl-2.7ns was smaller than the ratio with PACl-2.1c at around pH 8, possibly as a result of a reduction of the colloid charge density of the PACl as the basicity was increased from 2.1 to 2.7. Liquid (27)Al NMR analysis revealed that PACl-2.1c contained Al30 species, which was not the case for PACl-2.1b or PACl-2.7ns. This result suggests that Al30 species probably played a major role in virus removal during the coagulation process. In summary, PACl-2.1c, which has high colloidal aluminum content, contains Al30 species, and has a high colloid charge density, removed viruses more efficiently (>4 log10 for infectious viruses) than the other aluminum-based coagulants-including commercially available PACls (basicity 1.5-1.8), alum, and PACl-2.7ns-over the entire tested pH (6-8) and coagulant dosage (0.54-5.4 mg-Al/L) ranges.

  8. High-power ultrafast Yb:fiber laser frequency combs using commercially available components and basic fiber tools

    Science.gov (United States)

    Li, Xinlong; Reber, Melanie A. R.; Corder, Christopher; Chen, Yuning; Zhao, Peng; Allison, Thomas K.

    2016-09-01

    We present a detailed description of the design, construction, and performance of high-power ultrafast Yb:fiber laser frequency combs in operation in our laboratory. We discuss two such laser systems: an 87 MHz, 9 W, 85 fs laser operating at 1060 nm and an 87 MHz, 80 W, 155 fs laser operating at 1035 nm. Both are constructed using low-cost, commercially available components, and can be assembled using only basic tools for cleaving and splicing single-mode fibers. We describe practical methods for achieving and characterizing low-noise single-pulse operation and long-term stability from Yb:fiber oscillators based on nonlinear polarization evolution. Stabilization of the combs using a variety of transducers, including a new method for tuning the carrier-envelope offset frequency, is discussed. High average power is achieved through chirped-pulse amplification in simple fiber amplifiers based on double-clad photonic crystal fibers. We describe the use of these combs in several applications, including ultrasensitive femtosecond time-resolved spectroscopy and cavity-enhanced high-order harmonic generation.

  9. Information science and the scientist. A look at information requirements and the technologies available to scientists in the pursuit of information

    OpenAIRE

    1990-01-01

    A review article looking at the type of information requirements commonly shared by scientists and their use of traditional information services. Areas covered include primary requirements of IFE (Institute of Freshwater Ecology) staff, pure versus applied research, informal and personal sources of information, and traditional library and information services. It goes on to describe how research into information systems and technology may improve the wider accessibility and use of information...

  10. High phosphate availability as a possible cause for massive cyanobacterial production of oxygen in the Paleoproterozoic atmosphere

    Science.gov (United States)

    Papineau, Dominic; Purohit, Ritesh; Fogel, Marilyn L.; Shields-Zhou, Graham A.

    2013-01-01

    have arisen from the biological response to high phosphate availability. We conclude that increased phosphate availability during and after the Paleoproterozoic Lomagundi-Jatuli event likely caused cyanobacterial blooms and was a key factor in the oxygenation of Earth's atmosphere. Increasing oxygenation of the shallow ocean seafloor favored the removal of excess phosphate as authigenic apatite, thus dampening effects of weathering increases on organic burial and marine δ13Ccarb after about 2.0 Ga.

  11. Identification of Microorganisms in Duck Meat Products Available in Korea and the Effect of High Hydrostatic Pressure.

    Science.gov (United States)

    Kim, Hyun-Joo; Yong, Hae In; Lee, Hyun Jung; Jung, Samooel; Kwon, Joong-Ho; Heo, Kang Nyung; Jo, Cheorun

    2016-01-01

    The objective of this study was to investigate the microbial count of duck meat and duck meat products commercially available in Korea. High hydrostatic pressure (HHP) treatment was applied at 0.1, 300, 400, and 500 MPa for 5 min to enhance the microbiological safety of duck meats. The levels of total aerobic bacteria were in the ranges of 3.53-6.19 and 3.62-6.85 Log CFU/g in raw and smoked duck products, respectively. By DNA sequence analysis, we identified microorganisms responsible for spoilage, with the most common species in the raw and smoked duck products being Aeromonas spp. or Pseudomonas spp. and Leuconostoc mesenteroides, respectively. HHP treatment significantly reduced the levels of total aerobic bacteria in raw and smoked duck products. This study demonstrates that HHP treatment may be used to effectively improve the safety of raw and smoked duck meat products.

  12. Abnormally High Content of Free Glucosamine Residues Identified in a Preparation of Commercially Available Porcine Intestinal Heparan Sulfate.

    Science.gov (United States)

    Mulloy, Barbara; Wu, Nian; Gyapon-Quast, Frederick; Lin, Lei; Zhang, Fuming; Pickering, Matthew C; Linhardt, Robert J; Feizi, Ten; Chai, Wengang

    2016-07-05

    Heparan sulfate (HS) polysaccharides are ubiquitous in animal tissues as components of proteoglycans, and they participate in many important biological processes. HS carbohydrate chains are complex and can contain rare structural components such as N-unsubstituted glucosamine (GlcN). Commercially available HS preparations have been invaluable in many types of research activities. In the course of preparing microarrays to include probes derived from HS oligosaccharides, we found an unusually high content of GlcN residue in a recently purchased batch of porcine intestinal mucosal HS. Composition and sequence analysis by mass spectrometry of the oligosaccharides obtained after heparin lyase III digestion of the polysaccharide indicated two and three GlcN in the tetrasaccharide and hexasaccharide fractions, respectively. (1)H NMR of the intact polysaccharide showed that this unusual batch differed strikingly from other HS preparations obtained from bovine kidney and porcine intestine. The very high content of GlcN (30%) and low content of GlcNAc (4.2%) determined by disaccharide composition analysis indicated that N-deacetylation and/or N-desulfation may have taken place. HS is widely used by the scientific community to investigate HS structures and activities. Great care has to be taken in drawing conclusions from investigations of structural features of HS and specificities of HS interaction with proteins when commercial HS is used without further analysis. Pending the availability of a validated commercial HS reference preparation, our data may be useful to members of the scientific community who have used the present preparation in their studies.

  13. Abnormally High Content of Free Glucosamine Residues Identified in a Preparation of Commercially Available Porcine Intestinal Heparan Sulfate

    Science.gov (United States)

    2016-01-01

    Heparan sulfate (HS) polysaccharides are ubiquitous in animal tissues as components of proteoglycans, and they participate in many important biological processes. HS carbohydrate chains are complex and can contain rare structural components such as N-unsubstituted glucosamine (GlcN). Commercially available HS preparations have been invaluable in many types of research activities. In the course of preparing microarrays to include probes derived from HS oligosaccharides, we found an unusually high content of GlcN residue in a recently purchased batch of porcine intestinal mucosal HS. Composition and sequence analysis by mass spectrometry of the oligosaccharides obtained after heparin lyase III digestion of the polysaccharide indicated two and three GlcN in the tetrasaccharide and hexasaccharide fractions, respectively. 1H NMR of the intact polysaccharide showed that this unusual batch differed strikingly from other HS preparations obtained from bovine kidney and porcine intestine. The very high content of GlcN (30%) and low content of GlcNAc (4.2%) determined by disaccharide composition analysis indicated that N-deacetylation and/or N-desulfation may have taken place. HS is widely used by the scientific community to investigate HS structures and activities. Great care has to be taken in drawing conclusions from investigations of structural features of HS and specificities of HS interaction with proteins when commercial HS is used without further analysis. Pending the availability of a validated commercial HS reference preparation, our data may be useful to members of the scientific community who have used the present preparation in their studies. PMID:27295282

  14. Attributes of Seabuckthorn (Hippophae rhamnoides L. to Meet Nutritional Requirements in High Altitude.

    Directory of Open Access Journals (Sweden)

    Tsering Stobdan

    2010-03-01

    Full Text Available The diet of humans living in different geographical and climatic regions of the earth varies greatly in both quantity and composition of foods. Evidence is accumulating that indicates that there is a high risk of malnutrition at high altitude because of the usual lack of fresh food and environmental factors. Lack of nutritious diet in the difficult terrain is a potential stressor that elicits oxidative stress. The excretion of minerals from the body is higher in high altitude condition. The altered nutritional requirement can be met to a large extend by regular consumption of locally grown fruits and vegetables. Results of analysis of Seabuckthorn growing in Leh valley of Trans-Himalaya showed the presence of high content of multivitamins including vitamin C (275 mg/100g, vitamin A (432.4 IU/100g, vitamin E (3.54 mg/100g, Riboflavin (1.45 mg/100g, Niacin (68.4 mg/100g, Pantothenic acid (0.85 mcg/100g, vitamin B-6 (1.12 mg/100g, and vitamin B-2 (5.4 mcg/100g. Similarly, mineral elements composition revealed high amount of minerals including potassium (647.2 mg/l, calcium (176.6 mg/l, iron (30.9 mg/l, magnesium (22.5 mg/l, phosphorous (84.2 mg/l, sodium (414.2 mg/l, zinc (1.4 mg/l, copper (0.7 mg/l, manganese (1.06 mg/l and selenium (0.53 mg/l.Defence Science Journal, 2010, 60(2, pp.226-230, DOI:http://dx.doi.org/10.14429/dsj.60.344

  15. Incorporating wind availability into land use regression modelling of air quality in mountainous high-density urban environment.

    Science.gov (United States)

    Shi, Yuan; Lau, Kevin Ka-Lun; Ng, Edward

    2017-08-01

    Urban air quality serves as an important function of the quality of urban life. Land use regression (LUR) modelling of air quality is essential for conducting health impacts assessment but more challenging in mountainous high-density urban scenario due to the complexities of the urban environment. In this study, a total of 21 LUR models are developed for seven kinds of air pollutants (gaseous air pollutants CO, NO2, NOx, O3, SO2 and particulate air pollutants PM2.5, PM10) with reference to three different time periods (summertime, wintertime and annual average of 5-year long-term hourly monitoring data from local air quality monitoring network) in Hong Kong. Under the mountainous high-density urban scenario, we improved the traditional LUR modelling method by incorporating wind availability information into LUR modelling based on surface geomorphometrical analysis. As a result, 269 independent variables were examined to develop the LUR models by using the "ADDRESS" independent variable selection method and stepwise multiple linear regression (MLR). Cross validation has been performed for each resultant model. The results show that wind-related variables are included in most of the resultant models as statistically significant independent variables. Compared with the traditional method, a maximum increase of 20% was achieved in the prediction performance of annual averaged NO2 concentration level by incorporating wind-related variables into LUR model development. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. High-power ultrafast Yb:fiber laser frequency combs using commercially available components and basic fiber tools

    CERN Document Server

    Li, X L; Corder, C; Chen, Y; Zhao, P; Allison, T K

    2016-01-01

    We present a detailed description of the design, construction, and performance of high-power ultrafast Yb:fiber laser frequency combs in operation in our laboratory. We discuss two such laser systems: an 87 MHz, 9 W, 85 fs laser operating at 1060 nm and an 87 MHz, 80 W, 155 fs laser operating at 1035 nm. Both are constructed using low-cost, commercially available components, and can be assembled using only basic tools for cleaving and splicing single-mode fibers. We describe practical methods for achieving and characterizing low-noise single-pulse operation and long-term stability from Yb:fiber oscillators based on nonlinear polarization evolution. Stabilization of the combs using a variety of transducers, including a new method for tuning the carrier-envelope offset frequency, is discussed. High average power is achieved through chirped-pulse amplification in simple fiber amplifiers based on double-clad photonic crystal fibers. We describe the use of these combs in several applications, including ultrasensit...

  17. Performance and production requirements for the optical components in a high-average-power laser system

    Energy Technology Data Exchange (ETDEWEB)

    Chow, R.; Doss, F.W.; Taylor, J.R.; Wong, J.N.

    1999-07-02

    Optical components needed for high-average-power lasers, such as those developed for Atomic Vapor Laser Isotope Separation (AVLIS), require high levels of performance and reliability. Over the past two decades, optical component requirements for this purpose have been optimized and performance and reliability have been demonstrated. Many of the optical components that are exposed to the high power laser light affect the quality of the beam as it is transported through the system. The specifications for these optics are described including a few parameters not previously reported and some component manufacturing and testing experience. Key words: High-average-power laser, coating efficiency, absorption, optical components

  18. Novel oxytocin receptor variants in laboring women requiring high doses of oxytocin.

    Science.gov (United States)

    Reinl, Erin L; Goodwin, Zane A; Raghuraman, Nandini; Lee, Grace Y; Jo, Erin Y; Gezahegn, Beakal M; Pillai, Meghan K; Cahill, Alison G; de Guzman Strong, Cristina; England, Sarah K

    2017-08-01

    Although oxytocin commonly is used to augment or induce labor, it is difficult to predict its effectiveness because oxytocin dose requirements vary significantly among women. One possibility is that women requiring high or low doses of oxytocin have variations in the oxytocin receptor gene. To identify oxytocin receptor gene variants in laboring women with low and high oxytocin dosage requirements. Term, nulliparous women requiring oxytocin doses of ≤4 mU/min (low-dose-requiring, n = 83) or ≥20 mU/min (high-dose-requiring, n = 104) for labor augmentation or induction provided consent to a postpartum blood draw as a source of genomic DNA. Targeted-amplicon sequencing (coverage >30×) with MiSeq (Illumina) was performed to discover variants in the coding exons of the oxytocin receptor gene. Baseline relevant clinical history, outcomes, demographics, and oxytocin receptor gene sequence variants and their allele frequencies were compared between low-dose-requiring and high-dose-requiring women. The Scale-Invariant Feature Transform algorithm was used to predict the effect of variants on oxytocin receptor function. The Fisher exact or χ(2) tests were used for categorical variables, and Student t tests or Wilcoxon rank sum tests were used for continuous variables. A P value labor induction and required prostaglandins. High-dose-requiring women were more likely to undergo cesarean delivery for first-stage arrest and less likely to undergo cesarean delivery for nonreassuring fetal status. Targeted sequencing of the oxytocin receptor gene in the total cohort (n = 187) revealed 30 distinct coding variants: 17 nonsynonymous, 11 synonymous, and 2 small structural variants. One novel variant (A243T) was found in both the low- and high-dose-requiring groups. Three novel variants (Y106H, A240_A249del, and P197delfs*206) resulting in an amino acid substitution, loss of 9 amino acids, and a frameshift stop mutation, respectively, were identified only in low-dose-requiring

  19. Sphagnum-dominated bog systems are highly effective yet variable sources of bio-available iron to marine waters.

    Science.gov (United States)

    Krachler, Regina; Krachler, Rudolf F; Wallner, Gabriele; Steier, Peter; El Abiead, Yasin; Wiesinger, Hubert; Jirsa, Franz; Keppler, Bernhard K

    2016-06-15

    Iron is a micronutrient of particular interest as low levels of iron limit primary production of phytoplankton and carbon fluxes in extended regions of the world's oceans. Sphagnum-peatland runoff is extraordinarily rich in dissolved humic-bound iron. Given that several of the world's largest wetlands are Sphagnum-dominated peatlands, this ecosystem type may serve as one of the major sources of iron to the ocean. Here, we studied five near-coastal creeks in North Scotland using freshwater/seawater mixing experiments of natural creek water and synthetic seawater based on a (59)Fe radiotracer technique combined with isotopic characterization of dissolved organic carbon by Accelerator Mass Spectrometry. Three of the creeks meander through healthy Sphagnum-dominated peat bogs and the two others through modified peatlands which have been subject to artificial drainage for centuries. The results revealed that, at the time of sampling (August 16-24, 2014), the creeks that run through modified peatlands delivered 11-15μg iron per liter creek water to seawater, whereas the creeks that run through intact peatlands delivered 350-470μg iron per liter creek water to seawater. To find out whether this humic-bound iron is bio-available to marine algae, we performed algal growth tests using the unicellular flagellated marine prymnesiophyte Diacronema lutheri and the unicellular marine green alga Chlorella salina, respectively. In both cases, the riverine humic material provided a highly bio-available source of iron to the marine algae. These results add a new item to the list of ecosystem services of Sphagnum-peatlands.

  20. Sphagnum-dominated bog systems are highly effective yet variable sources of bio-available iron to marine waters

    Energy Technology Data Exchange (ETDEWEB)

    Krachler, Regina, E-mail: regina.krachler@univie.ac.at [Institute of Inorganic Chemistry, University of Vienna, Währingerstraße 42, 1090 Vienna (Austria); Krachler, Rudolf F.; Wallner, Gabriele [Institute of Inorganic Chemistry, University of Vienna, Währingerstraße 42, 1090 Vienna (Austria); Steier, Peter [Isotope Research and Nuclear Physics, University of Vienna, Währingerstraße 17, 1090 Vienna (Austria); El Abiead, Yasin; Wiesinger, Hubert [Institute of Inorganic Chemistry, University of Vienna, Währingerstraße 42, 1090 Vienna (Austria); Jirsa, Franz [Institute of Inorganic Chemistry, University of Vienna, Währingerstraße 42, 1090 Vienna (Austria); University of Johannesburg, Department of Zoology, P. O. Box 524, Auckland Park 2006 (South Africa); Keppler, Bernhard K. [Institute of Inorganic Chemistry, University of Vienna, Währingerstraße 42, 1090 Vienna (Austria)

    2016-06-15

    Iron is a micronutrient of particular interest as low levels of iron limit primary production of phytoplankton and carbon fluxes in extended regions of the world's oceans. Sphagnum-peatland runoff is extraordinarily rich in dissolved humic-bound iron. Given that several of the world's largest wetlands are Sphagnum-dominated peatlands, this ecosystem type may serve as one of the major sources of iron to the ocean. Here, we studied five near-coastal creeks in North Scotland using freshwater/seawater mixing experiments of natural creek water and synthetic seawater based on a {sup 59}Fe radiotracer technique combined with isotopic characterization of dissolved organic carbon by Accelerator Mass Spectrometry. Three of the creeks meander through healthy Sphagnum-dominated peat bogs and the two others through modified peatlands which have been subject to artificial drainage for centuries. The results revealed that, at the time of sampling (August 16–24, 2014), the creeks that run through modified peatlands delivered 11–15 μg iron per liter creek water to seawater, whereas the creeks that run through intact peatlands delivered 350–470 μg iron per liter creek water to seawater. To find out whether this humic-bound iron is bio-available to marine algae, we performed algal growth tests using the unicellular flagellated marine prymnesiophyte Diacronema lutheri and the unicellular marine green alga Chlorella salina, respectively. In both cases, the riverine humic material provided a highly bio-available source of iron to the marine algae. These results add a new item to the list of ecosystem services of Sphagnum-peatlands. - Highlights: • We report that peat-bogs are sources of bio-available iron to marine algae. • This iron is effectively chelated with aquatic humic acids. • The radiocarbon age of the iron-carrying aquatic humic acids was up to 550 years. • Analysis was focused on mixing experiments of iron-rich creek water with seawater. • Drained

  1. Development of High-Level Safety Requirements for a Pyroprocessing Facility

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Seok Jun; Jo, Woo Jin; You, Gil Sung; Choung, Won Myung; Lee, Ho Hee; Kim, Hyun Min; Jeon, Hong Rae; Ku, Jeong Hoe; Lee, Hyo Jik [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    Korea Atomic Energy Research Institute (KAERI) has been developing a pyroproceesing technology to reduce the waste volume and recycle some elements. The pyroprocessing includes several treatment processes which are related with not only radiological and physical but also chemical and electrochemical properties. Thus, it is of importance to establish safety design requirements considering all the aspects of those properties for a reliable pyroprocessing facility. In this study, high-level requirements are presented in terms of not only radiation protection, nuclear criticality, fire protection, and seismic safety but also confinement and chemical safety for the unique characteristics of a pyroprocessing facility. Several high-level safety design requirements such as radiation protection, nuclear criticality, fire protection, seismic, confinement, and chemical processing were presented for a pyroprocessing facility. The requirements must fulfill domestic and international safety technology standards for a nuclear facility. Furthermore, additional requirements should be considered for the unique electrochemical treatments in a pyroprocessing facility.

  2. NOAA Operational Model Archive Distribution System (NOMADS): High Availability Applications for Reliable Real Time Access to Operational Model Data

    Science.gov (United States)

    Alpert, J. C.; Wang, J.

    2009-12-01

    To reduce the impact of natural hazards and environmental changes, the National Centers for Environmental Prediction (NCEP) provide first alert and a preferred partner for environmental prediction services, and represents a critical national resource to operational and research communities affected by climate, weather and water. NOMADS is now delivering high availability services as part of NOAA’s official real time data dissemination at its Web Operations Center (WOC) server. The WOC is a web service used by organizational units in and outside NOAA, and acts as a data repository where public information can be posted to a secure and scalable content server. A goal is to foster collaborations among the research and education communities, value added retailers, and public access for science and development efforts aimed at advancing modeling and GEO-related tasks. The user (client) executes what is efficient to execute on the client and the server efficiently provides format independent access services. Client applications can execute on the server, if it is desired, but the same program can be executed on the client side with no loss of efficiency. In this way this paradigm lends itself to aggregation servers that act as servers of servers listing, searching catalogs of holdings, data mining, and updating information from the metadata descriptions that enable collections of data in disparate places to be simultaneously accessed, with results processed on servers and clients to produce a needed answer. The services used to access the operational model data output are the Open-source Project for a Network Data Access Protocol (OPeNDAP), implemented with the Grid Analysis and Display System (GrADS) Data Server (GDS), and applications for slicing, dicing and area sub-setting the large matrix of real time model data holdings. This approach insures an efficient use of computer resources because users transmit/receive only the data necessary for their tasks including

  3. Requirements for high level models supporting design space exploration in model-based systems engineering

    NARCIS (Netherlands)

    Haveman, Steven; Bonnema, Gerrit Maarten

    2013-01-01

    Most formal models are used in detailed design and focus on a single domain. Few effective approaches exist that can effectively tie these lower level models to a high level system model during design space exploration. This complicates the validation of high level system requirements during

  4. [Not Available].

    Science.gov (United States)

    Spivak, M

    1987-01-01

    Some ideas, whether right or wrong, seem never to die, whatever might be the general evolution of knowledge, of science, or simply of good common sense. This is exactly the case with physical education or sports. For centuries, and especially since the middle of the nineteenth century, its advocates have fought for recognition of its all-round virtues, taken as a concept. But to attain a high level of recognition, not only in society but in official government circles, certain conditions were necessary. Education as a whole, around the middle of the nineteenth century, had to be strict and similar to military drill to be considered efficient, although the French middle classes and bourgeoisie had very little taste for the military. Although they admired physical prowess they had a horror of regimentation. But later on, when the Prussians so easily defeated Austria, feelings of doubt in French superiority began to spread, and a handful of theoreticians of physical exercise tried to show that to combat the so-called degeneration of the race, it was essential to impose a system of education in which physical exercise, coupled with military drill, still had an important place. As scientific arguments they referred to the theories of evolution and its then accepted principle, according to Lamarck, or the transmission of acquired properties and character. Darwin was still unknown in France at that time. These zealous advocates succeeded in convincing the Minister of Public Education, Victor Duruy, to include gymnastics in the normal course of studies in all schools, and by 1869 one can say that a craze for all types of physical exercise and sport had spread into many levels of society. That was the start of a never-ending movement which has passed through various stages of evolution corresponding to the changes in society itself. It has therefore changed its methods, its ways, its forms, but the overall principle remains the same, in spite of the improved understanding

  5. [Not Available].

    Science.gov (United States)

    1992-03-25

    Archersstar Sudha Bhuchar, right, launches a video on breast screening for women from ethnic minorities, sponsored by the NHS. The video is available in six languages. Ms Bhuchar is pictured with programme co-ordinator Julietta Patrick.

  6. Places available**

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch ** The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: ACCESS 2000 - niveau 1 : 13 & 14.11.03 (2 jours) C++ for Particle Physicists : 17 – 21.11.03 (6 X 3-hour lectures) Programmation automate Schneider TSX Premium – niveau 2 : 18 – 21.11.03 (4 jours) JAVA 2 Enterprise Edition – Part 1 : WEB Applications : 20 & ...

  7. High-pressure pulsed avalanche discharges: Formulas for required preionization density and rate for homogeneity

    Energy Technology Data Exchange (ETDEWEB)

    Brenning, N.; Axnaes, I.; Nilsson, J.O.; Eninger, J.E. [Royal Inst. of Tech., Stockholm (Sweden)

    1997-02-01

    The requirements on preionization for the formation of spatially homogeneous pulsed avalanche discharges are examined. The authors derive two formulas which apply in the case of a slowly rising electric field, one which gives the required preionization density at breakdown, and one which gives the required preionization rate. These quantities are expressed as functions of the electrochemical properties of the gas, the neutral density, and the electric field rise time. They also treat the statistical effect that the electrons tend to form groups, in contrast to being randomly distributed in space, during the prebreakdown phase. This process is found to increase the required preionization rate significantly, typically by a factor of five for a discharge at atmospheric pressure. Homogeneous high-pressure discharges have been used for laser excitation, and have also been proposed for chemical plasma processing (ozone production) because of their good scaling properties and high efficiency.

  8. Available phosphorus levels in diets supplemented with phytase for male broilers aged 22 to 42 days kept in a high-temperature environment

    Directory of Open Access Journals (Sweden)

    Tarciso Tizziani

    2016-02-01

    Full Text Available ABSTRACT This study was conducted to evaluate the effect of reduction of the available phosphorus (avP in diets supplemented with 500 FTU/kg phytase on performance, carcass characteristics, and bone mineralization of broilers aged 22 to 42 days kept in a high-temperature environment. A total of 336 Cobb broilers with an average initial weight of 0.883±0.005 kg were distributed in a completely randomized design with six treatments - a positive control (0.354 and 0.309% avP without addition of bacterial phytase for the phases of 22 to 33 and 34 to 42 days, respectively, and another five diets with inclusion of phytase (500 FTU and reduction of the level of avP (0.354, 0.294, 0.233, 0.173, and 0.112%; and 0.309, 0.258, 0.207, 0.156, and 0.106% for the phases of 22 to 33 and 34 to 42 days, respectively - eight replicates, and seven birds per cage. The experimental diets were formulated to meet all nutritional requirements, except for avP and calcium. Birds were kept in climatic chambers at a temperature of 32.2±0.4 °C and air humidity of 65.3±5.9%. Phytase acted by making the phytate P available in diets with reduction in the levels of avP, keeping feed intake, weight gain, feed:gain, and carcass characteristics unchanged. Treatments affected ash and calcium deposition and the Ca:P ratio in the bone; the group fed the diets with 0.112 and 0.106%, from 22 to 33 and 34 to 42 days of age, respectively, obtained the lowest values, although the phosphorus deposition in the bone was not affected. Diets supplemented with 500 FTU of phytase, with available phosphorus reduced to 0.173 and 0.156%, and a fixed Ca:avP ratio of 2.1:1, meet the requirements of broilers aged 22 to 33 and 34 to 42 days, respectively, reared in a high-temperature environment.

  9. Places available

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Places available The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses : Introduction à Outlook : 19.8.2004 (1 journée) Outlook (short course I) : E-mail : 31.8.2004 (2 hours, morning) Outlook (short course II) : Calendar, Tasks and Notes : 31.8.2004 (2 hours, afternoon) Instructor-led WBTechT Study or Follow-up for Microsoft Applications : 7.9.2004 (morning) Outlook (short course III) : Meetings and Delegation : 7.9.2004 (2 hours, afternoon) Introduction ...

  10. Study Water Availability of Malino River to Meet the Need of Water Requirement in District Ongka Malino, Central Sulawesi of Indonesia

    Directory of Open Access Journals (Sweden)

    I Wayan Sutapa

    2015-06-01

    Full Text Available Global climate change is marked by changes in weather patterns and climate patterns result in increased or reduced rainfall in some areas. Decreased rainfall as input variables watershed due to irregularities global climate will affect the flow of the river, both annual river flow and seasonal dynamics. One of the basic human needs are affected by global warming is the water. The importance of adequate water supply for the community public hearings mandated by the declaration of the United Nations in 2000 which set the year 2015 as the horizon for achieving the Millennium Development Goal's (MDG’s. This is confirmed again at the Earth Summit in Johannesburg in September 2002 on the preparation of programs and strategies in 2015 for water supply and sanitation. In this study, the availability of water is analyzed by the FJ. Mock model and water needs were analyzed based on the guidelines for water needs. The analysis showed that there is excess water in January and May to August and the lack of water in the Month of February and the month of September to December. To overcome the shortage of water is necessary to change the cropping pattern and prioritize water for the needs of the population and livestock.

  11. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: C++ Programming Level 2 - Traps & Pitfalls:  16 - 19.7.02 (4 days) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Technical Training Monique Duval Tel.74924 monique.duval@cern.ch

  12. Flight validation of ground-based assessment for control power requirements at high angles of attack

    Science.gov (United States)

    Ogburn, Marilyn E.; Ross, Holly M.; Foster, John V.; Pahle, Joseph W.; Sternberg, Charles A.; Traven, Ricardo; Lackey, James B.; Abbott, Troy D.

    1994-01-01

    A review is presented in viewgraph format of an ongoing NASA/U.S. Navy study to determine control power requirements at high angles of attack for the next generation high-performance aircraft. This paper focuses on recent flight test activities using the NASA High Alpha Research Vehicle (HARV), which are intended to validate results of previous ground-based simulation studies. The purpose of this study is discussed, and the overall program structure, approach, and objectives are described. Results from two areas of investigation are presented: (1) nose-down control power requirements and (2) lateral-directional control power requirements. Selected results which illustrate issues and challenges that are being addressed in the study are discussed including test methodology, comparisons between simulation and flight, and general lessons learned.

  13. Places available**

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. TECHNICAL TRAINING Monique Duval Tel. 74924technical.training@cern.ch ** The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: MATLAB Fundamentals and Programming Techniques (ML01) : 2 & 3.12.03 (2 days) Oracle 8i : SQL : 3 - 5.12.03 (3 days) The EDMS MTF in practice : 5.12.03 (afternoon, free of charge) Modeling Dynamic Systems with Simulink (SL01) : 8 & 9.12.03 (2 days) Signal Processing with MATLAB (SG01) : 11 & 12.12.03 (2 days) The JAVA Programming Language - l...

  14. Places available**

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. TECHNICAL TRAINING Monique Duval Tel. 74924 technical.training@cern.ch ** The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: JAVA 2 Enterprise Edition - Part 1 : WEB Applications : 20 & 21.11.03(2 days) FrontPage 2000 - niveau 1 : 20 & 21.11.03 (2 jours) Oracle 8i : SQL : 3 - 5.12.03 (3 days) Oracle 8i : Programming with PL/SQL : 8 - 10.12.03 (3 days) The JAVA Programming Language - leve...

  15. Places available**

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch ** The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: The JAVA Programming Language Level 1 :9 & 10.1.2004 (2 days) The JAVA Programming Language Level 2 : 11 to 13.1.2004 (3 days) Hands-on Introduction to Python Programming : 16 - 18.2.2004 (3 days - free of charge) CLEAN-2002 : Working in a Cleanroom : 10.3.2004 (afternoon - free of charge) C++ for Particle Physicists : 8 - 12.3.2004...

  16. Places available**

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. ** The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses : EXCEL 2000 - niveau 1 : 20 & 22.10.03 (2 jours) CLEAN-2002 : Working in a Cleanroom (free of charge) : 23.10.03 (half day) The EDMS-MTF in practice (free of charge) :  28 -  30.10.03 (6 half-day sessions) AutoCAD 2002 - Level 1 : 3, 4, 12, 13.11.03 (4 days) LabVIEW TestStand ver. 3 : 4 & 5.11.03 (2 days) Introduction to Pspice : 4.11.03 p.m. (half-day) Hands-on Introduction to Python Programm...

  17. Places available**

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch ** The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: MATLAB Fundamentals and Programming Techniques (ML01) :2 & 3.12.03 (2 days) Oracle 8i : SQL : 3 - 5.12.03 (3 days) The EDMS MTF in practice : 5.12.03 (afternoon, free of charge) Modeling Dynamic Systems with Simulink (SL01) : 8 & 9.12.03 (2 days) Signal Processing with MATLAB (SG01) : 11 & ...

  18. Places available**

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch ** The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: Project Planning with MS-Project : 15 & 22.1.2004 (2 days) Joint PVSS JCOP Framework Course : 2 sessions : 2 - 6.2.2004 and 16 - 20-2-2004 (5 days) Hands-on Introduction to Python Programming : 16 - 18.2.2004 (3 days - free of charge) C++ for Particle Physicists : 8 - 12.3.2004 ( 6 X 4-hour sessions)

  19. Places available**

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt.TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch ** The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: The JAVA Programming Language Level 1 : 9 & 10.1.2004 (2 days) The JAVA Programming Language Level 2 : 11 to 13.1.2004 (3 days) LabVIEW base 1 : 25 - 27.2.2004 (3 jours) CLEAN-2002 : Working in a Cleanroom : 10.3.2004 (afternoon - free of charge) C++ for Particle Physicists : 8 - 12.3.2004 ( 6 X 4-hour sessions) LabVIEW Basics 1 : 22 - 24.3.20...

  20. Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis.

    Directory of Open Access Journals (Sweden)

    Emmanuel Dias-Neto

    Full Text Available BACKGROUND: Combinatorial phage display has been used in the last 20 years in the identification of protein-ligands and protein-protein interactions, uncovering relevant molecular recognition events. Rate-limiting steps of combinatorial phage display library selection are (i the counting of transducing units and (ii the sequencing of the encoded displayed ligands. Here, we adapted emerging genomic technologies to minimize such challenges. METHODOLOGY/PRINCIPAL FINDINGS: We gained efficiency by applying in tandem real-time PCR for rapid quantification to enable bacteria-free phage display library screening, and added phage DNA next-generation sequencing for large-scale ligand analysis, reporting a fully integrated set of high-throughput quantitative and analytical tools. The approach is far less labor-intensive and allows rigorous quantification; for medical applications, including selections in patients, it also represents an advance for quantitative distribution analysis and ligand identification of hundreds of thousands of targeted particles from patient-derived biopsy or autopsy in a longer timeframe post library administration. Additional advantages over current methods include increased sensitivity, less variability, enhanced linearity, scalability, and accuracy at much lower cost. Sequences obtained by qPhage plus pyrosequencing were similar to a dataset produced from conventional Sanger-sequenced transducing-units (TU, with no biases due to GC content, codon usage, and amino acid or peptide frequency. These tools allow phage display selection and ligand analysis at >1,000-fold faster rate, and reduce costs approximately 250-fold for generating 10(6 ligand sequences. CONCLUSIONS/SIGNIFICANCE: Our analyses demonstrates that whereas this approach correlates with the traditional colony-counting, it is also capable of a much larger sampling, allowing a faster, less expensive, more accurate and consistent analysis of phage enrichment. Overall

  1. A Methodology for Writing High Quality Requirements Specification and Evaluating Existing Ones

    Science.gov (United States)

    Rosenberg, Linda; Hammer, Theodore

    1999-01-01

    Requirements development and management have always been critical in the implementation of software systems; engineers are unable to build what analysts can't define. It is generally accepted that the earlier in the life cycle potential risks are identified the easier it is to eliminate or manage the conditions that introduce that risk. Problems that are not found until testing are approximately 14 times more costly to fix than if the problem was found in the requirement phase. The requirements specification, as the first tangible representation of the capability to be produced, establishes the basis for all of the project's engineering management and assurance functions. If the quality of the requirements specification is poor it can give rise to risks in all areas of the project. Recently, automated tools have become available to support requirements management. The use of these tools not only provides support in the definition and tracing of requirements, but it also opens the door to effective use of metrics in characterizing and assessing the quality of the requirement specifications.

  2. Analysis of Valve Requirements for High-Efficiency Digital Displacement Fluid Power Motors

    DEFF Research Database (Denmark)

    Rømer, Daniel; Johansen, Per; Pedersen, Henrik C.

    2013-01-01

    Digital displacement fluid power motors have been shown to enable high-efficiency operation in a wide operation range, including the part load range where conventional fluid power motors suffers from poor efficiencies. The use of these digital displacement motors set new requirements for the valve...... technology, as very fast switching and low pressure loss is needed to obtain high-efficient motor operation. Two central parameters describing the valve operation are the valve switching time and the flow-pressure coefficient. These requirements are important inputs for the mechatronic valve design process...

  3. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: C++ Programming Level 2 - Traps & Pitfalls:  16 - 19.7.02 (4 days) Frontpage 2000 - level 1 :  22 - 23.7.02  (2 days) Introduction à Windows 2000 au CERN : 24.7.02 (après-midi) CLEAN-2002 : Travailler en salle blanche (cours gratuit) : 13.08.2002 (matin) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Technical Training Monique Duval Tel.74924 monique.duval@cern.ch

  4. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: December 2002   PCAD Schémas - Débutants :  5 & 6.12.02  (2 jours) PCAD PCB - Débutants :  9 - 11.12.02  (3 jours) FrontPage 2000 - level 1:  9 & 10.12.02  (2 days) Introduction à la CAO Cadence (cours gratuit) :  10 & 11.12.02  (2 jours) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Technical Training Monique Duval Tel.74924 monique.duval@cern.ch

  5. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: CLEAN-2002 : Travailler en salle blanche (cours gratuit) : 13.08.2002 (matin) Introduction to the CERN Enginnering Data Management System :  27.8.02  (1 day) The CERN Engineering Data Management System for Advanced Users :  28.8.02  (1 day) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Technical Training Monique Duval Tel.74924 monique.duval@cern.ch    

  6. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Introduction to Databases :  3 - 4.7.01 (2 days) The JAVA programming language Level 2 : 4 - 6.7.01 (3 days) Enterprise JavaBeans :  9 - 11.7.01 (3 days) Design Patterns :  10 - 12.7.01 (3 days) C++ for Particle Physicists :  23 - 27.7.01 (6 3-hour lectures) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt.

  7. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Introduction to Perl 5 : 2 - 3.7.01 (2 days) Introduction to Databases :  3 - 4.7.01 (2 days) JAVA programming language Level 2 : 4 - 6.7.01 (3 days) Enterprise JavaBeans :  9 - 11.7.01 (3 days) Design Patterns :  10 - 12.7.01 (3 days) C++ for Particle Physicists :  23 - 27.7.01 (6 3-hour lectures) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt.

  8. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses: Conception de PCB rapides dans le flot Cadence : 11.6.03 (matin) EXCEL 2000 - level 1 : 12 & 13.6.03 (2 days) Introduction to PVSS : 16.6.03 (p.m.) Basic PVSS : 17 - 19.6.03 (3 days) Réalisation de PCB rapides dans le flot Cadence : 17.6.03 (matin) PVSS - JCOP Framework Tutorial : 20.6.03 (1 day) Programmation automate Schneider : Programmation automate Schneider TSX Premium - 2ème niveau : 24 - 27.6.03 (4 jours) - audience : toute personne qui veux maitriser la mise en uvre et la programmation des fonctions spécialisées d'un automate TSX Premium - objectifs : maitriser la mise en uvre et la programmation des fonctions spécialisées d'un automate TSX Premium Cours de sécurité : Etre TSO au CERN : Prochaines sessions : 24, 25 & 27.6.03 - 4, 5 & 7.11.03 (session de 3 jours) ** The number of places available may vary. Please check our Web site to find out the current availability. If you wish to participate in one of these courses, pl...

  9. [Not Available].

    Science.gov (United States)

    Bourguignon, Laurent; Goutelle, Sylvain; Gérard, Cécile; Guillermet, Anne; de Saint Martin, Julie Burdin; Maire, Pascal; Ducher, Michel

    2009-01-01

    The use of amikacin is difficult because of its toxicity and its pharmacokinetic variability. This variability is almost ignored in adult standard dosage regimens since only the weight is used in the dose calculation. Our objective is to test if the pharmacokinetic of amikacin can be regarded as homogenous, and if the method for calculating the dose according to patients' weight is appropriate. From a cohort of 580 patients, five groups of patients were created by statistical data partitioning. A population pharmacokinetic analysis was performed in each group. The adult population is not homogeneous in term of pharmacokinetics. The doses required to achieve a maximum concentration of 60mg/L are strongly different (585 to 1507mg) between groups. The exclusive use of the weight to calculate the dose of amikacine appears inappropriate for 80% of the patients, showing the limits of the formulae for calculating doses of aminoglycosides.

  10. 76 FR 18298 - Notice of Availability of a Final Environmental Impact Statement for the DesertXpress High-Speed...

    Science.gov (United States)

    2011-04-01

    ... Considering Environmental Impacts (64 FR 28545, May 26, 1999). The Bureau of Land Management (BLM), Surface... DesertXpress High-Speed Passenger Train Project AGENCY: Federal Railroad Administration (FRA), United... High-Speed Passenger Train Project (DesertXpress project). FRA is the Lead Agency for the...

  11. REQUIREMENT OF FLUIDITY OF HIGH WATER CONTENT MATERIALS FORTHE GETWAY-SIDE BACKFILLING TECHNIQUE

    Institute of Scientific and Technical Information of China (English)

    QiTaiyue; MaNianjie

    1996-01-01

    Through analyzing the effects of water consumption, diameter of solid particle, and flow velocity on the fluidity of high water content material slurry, the relationship among the fluidity, the isotropy of the slurry, and the pumping facilities applied in getway-side backfilling has been found. And the requirment of fluidity of high water content material for the design of getway-side backfilling technique is put forward in the paper.

  12. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: The CERN Engineering Data Management System for Advanced users :  13.6.02  (1 day) The CERN Engineering Data Management System for Local Administrators :  18.6.02  (1 day) AutoCAD 2002 - niveau 2 : 24 - 25.6.02 (2 jours) Frontpage 2000 - niveau 2 : 25 - 26.6.02 (2 jours) Object-oriented Analysis and Design :  2 - 5.7.02  (4 days) C++ Programming Level 2 - Traps & Pitfalls :  16 - 19.7.02  (4 days) C++ for Particle Physicists :  22 - 26.7.02  (6 * 3 hour lectures) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of the...

  13. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: LabView Hands-on (bilingue/bilingual - gratuit/free of charge) : 13.9.02 (a.m.) LabView DAQ Hands-on (bilingue/bilingual - gratuit/free of charge) : 13.9.02 (p.m.) AutoCAD 2002 - niveau 1 : 19, 20, 26, 27.9.02 (4 jours) LabView Base 1 : 23 - 25.9.02 (3 jours) LabView DAQ (E) : 26 - 27.9.02 (2 days) AutoCAD Mechanical 6 PowerPack (F) : 30.9, 1, 2, 9, 10, 11.10.02 (6 jours) CLEAN-2002 : Working in a Cleanroom (free of charge) : 10.10.02 (half-day, p.m.) AutoCAD 2002 - niveau 2 : 14 - 15.10.02 (2 jours) AutoCAD 2002 - Level 1 : 17, 18, 24, 25.10.02 (4 days) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Of...

  14. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Utilisation du simulateur Simplorer : 30.5 - 1.6.01 (3 jours) JAVA programming language level 1: 11-12.6.01 (2 days) LabView hands-on F ou E : 11.6.01 (1/2 journée) Comprehensive VHDL for EPLD/FPGA Design : 11 - 15.6.01 (5 days) Introduction au Langage C : 13 - 15.6.01 (3 jours) LabView Base 1 : 12 - 14.6.01 (3 jours) Habilitation électrique : superviseurs : 2 sessions d'une demi-journée les 12 et 19.6.01 Migration de LabVIEW 5 vers LabVIEW 6i Migration from LabVIEW 5 to LabVIEW 6I :  15.6.01 (1/2 journée/half-day) Introduction to Perl 5 : 2 - 3.7.01 (2 days) JAVA programming language level 2 : 4 - 6.7.01 (3 days) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : http://www.cern.ch/Training/ or fill in an 'application for training' form available from ...

  15. PLACES AVAILABLES

    CERN Document Server

    Technical Training; Tel. 74924

    2000-01-01

    Places are available in the following courses:   C++ for Particle Physicists 20 - 24.11.00 6 lectures CANbus 20.11.00 1 journée CANopen 21 et 22.11.00 2 jours Sécutiré dans les installations cryogéniques 21 et 22.11.00 2 demi-journées The JAVA programming language level 2 27 ­ 29.11.00 3 days Contract Follow-up 27.11.00 3 heures 1/2 Cryogénie (introduction) 4 ­ 8.12.00 ANSYS Introduction : langue a décider suivant majorité 5 ­ 7.12.00 3 jours EXCEL 7, 8, 13 et 14.12.00 4 jours Contract Follow-up 15.12.00 3 heures 1/2 If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : http://www.cern.ch/Training/ or fill in an “application for training” form available from your Divisional Secretariat or from your DTO (Divisional Training Officer)....

  16. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: Habilitation électrique : recyclage HT/BT : 11 - 15.3.2002  (2 * 2 heures) PVSS Basics :  8 - 12.4.02  (5 days) ELEC-2002 : Spring Term :  9, 11, 16, 18, 23, 25, 30.4.02 (7 * 2.5 hours) LabVIEW base 1 : 22 - 24.4.02 (3 jours) LabVIEW DSC (F) 25 & 26.4.02 (2 jours) LabVIEW Basics 2 : 13 & 14.5.02 (2 days) LabVIEW DAQ (F) : 15 & 16.5.02 (2 jours) Cours sur la migration AutoCAD :   AutoCAD : Mise à jour AutoCAD r-14 vers 2002 (2 jours) AutoCAD Mechanical PowerPack 6 basé sur AutoCAD 2002 (5 jours) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applica...

  17. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel 74924

    2002-01-01

    Places are available in the following courses: LabView hands-on : 21.01.02 (1/2 journée) LabView DAQ hands-on : 21.01.02 (1/2 journée) FileMaker Pro : 22 - 25.1.02 (4 jours) MS-Project 2000 : 24 & 25.01.02 (2 jours) Introduction au PC et à Windows 2000 au CERN : 29 - 30.1.02 (2 jours) LabView Base 1 : 4 - 6.2.02 (3 jours) LabView DAQ (E) : 7 & 8.02.02 (2 days) Hands-on Object-Oriented Design & Programming with Java : 11 - 13.02.02 (3 days) C++ for Particle Physicists : 11 - 15.3.2002 (6 * 3 hour lectures) Cours sur la migration AutoCAD : AutoCAD : Mise à jour AutoCAD r-14 vers 2002 (2 jours) AutoCAD Mechanical PowerPack 6 basé sur AutoCAD 2002 (5 jours) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO ...

  18. PLACES AVAILABLES

    CERN Multimedia

    Enseignement Technique; Tél. 74924; monique.duval@cern.ch

    2000-01-01

    Places are available in the following courses: LabView hands-on : 13.11.00 (4 hours) LabView Basics 1 : 14 ­ 16.11.00 (3 days) Nouveautés de WORD : 19 et 20.10.00 (2 jours) ACCESS 1er niveau : 30 ­ 31.10.00 (2 jours) Advanced C programming : 2 ­ 3.11.00 (2 days) Introduction à PowerPoint : 6.11.00 (1 journée) C++ for Particle Physicists : 20 ­ 24.11.00 (12 hours) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : http://www.cern.ch/Training/ or fill in an “application for training” form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt.

  19. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: PVSS basics :  18 - 22.2.02 (5 days) Introduction à la CAO CADENCE : 20 & 21.2.02 (2 jours) LabView Basics 1 :  4 - 6.3.02  (3 days) Introduction au VHDL et utilisation du simulateur de CADENCE : 6 & 7.3.02 (2 jours) LabView Base 2 : 11 & 12.3.02 (2 jours) C++ for Particle Physicists :  11 - 15.3.2002  (6 * 3 hour lectures) LabView Advanced :  13 - 15.3.02 (3 days) Cours sur la migration AutoCAD :   AutoCAD : Mise à jour AutoCAD r-14 vers 2002 (2 jours) AutoCAD Mechanical PowerPack 6 basé sur AutoCAD 2002 (5 jours) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO...

  20. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: Introduction à la CAO CADENCE : 20 & 21.2.02 (2 jours) LabView Basics 1 :  4 - 6.3.02  (3 days) Introduction au VHDL et utilisation du simulateur de CADENCE : 6 & 7.3.02 (2 jours) CLEAN-2002 : Working in a Clean Room :  7.3.2002  (1 day) LabView Base 2 : 11 & 12.3.02 (2 jours) C++ for Particle Physicists :  11 - 15.3.2002  (6 * 3 hour lectures) LabView Advanced :  13 - 15.3.02 (3 days) Cours sur la migration AutoCAD :   AutoCAD : Mise à jour AutoCAD r-14 vers 2002 (2 jours) AutoCAD Mechanical PowerPack 6 basé sur AutoCAD 2002 (5 jours) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisiona...

  1. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses: Hands-on Introduction to Python Programming: 11-13.08.2003(3 days) Introduction to the CERN Engineering Data Management System (EDMS): 26.08.2003 (1 day) The CERN Engineering Data Management System (EDMS) for Engineers: 27.08.2003 (1 day) CLEAN-2002 : Travailler en salle blanche : 4.09.2003 (une demi-journée) AutoCAD 2002 - Level 1: 4, 5, 15, 16.09.2003 (2 x 2 days) AutoCAD Mechanical 6 PowerPack : 17, 18, 25, 26.09.2003 et 2, 3.10.2003 (3 x 2 journées, français) AutoCAD 2002 - niveau 1 : 23, 24, 30.09.2003 et 1.10.2003 (2 x 2 journées) Introduction to the CERN Engineering Data Management System (EDMS): 23.09.2003 (1 day) The CERN Engineering Data Management System (EDMS) for Local Administrators: 24-25.09.2003 (2 days) AutoCAD 2002 - niveau 2 : 8 et 10.10.2003 (2 journées) CLEAN-2002: Working in a Cleanroom: 23.10.2003 (half day, p.m.) ** The number of places available may vary. Please ch...

  2. Places available**

    CERN Multimedia

    Places are available in the following courses: Hands-on Introduction to Python Programming: 11-13.08.2003 (3 days) Introduction to the CERN Engineering Data Management System (EDMS): 26.08.2003 (1 day) The CERN Engineering Data Management System (EDMS) for Engineers: 27.08.2003 (1 day) CLEAN-2002 : Travailler en salle blanche : 4.09.2003 (une demi-journée) AutoCAD 2002 - Level 1: 4, 5, 15, 16.09.2003 (2 x 2 days) AutoCAD Mechanical 6 PowerPack : 17, 18, 25, 26.09.2003 et 2, 3.10.2003 (3 x 2 journées, français) AutoCAD 2002 - niveau 1 : 23, 24, 30.09.2003 et 1.10.2003 (2 x 2 journées) Introduction to the CERN Engineering Data Management System (EDMS): 23.09.2003 (1 day) The CERN Engineering Data Management System (EDMS) for Local Administrators: 24-25.09.2003 (2 days) AutoCAD 2002 - niveau 2 : 8 et 10.10.2003 (2 journées) CLEAN-2002: Working in a Cleanroom: 23.10.2003 (half day, p.m.) ** The number of places available may vary. Please check our Web site to find out the current availabili...

  3. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: November 2002   Java Programming Language level 1 :  28 & 29.11.02  (2 days) December 2002   LabVIEW - DSC (English) :  2 - 3.12.02  (2 days) FileMaker (Français) :  2 - 5.12.02  (4 jours) PCAD Schémas - Débutants :  5 & 6.12.02  (2 jours) PCAD PCB - Débutants :  9 - 11.12.02  (3 jours) FrontPage 2000 - level 1:  9 & 10.12.02  (2 days) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Technical Training M...

  4. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: November 2002   Hands-on Object-Oriented Design and Programming with C++:  19 - 21.11.02  (3 days)  December 2002   LabVIEW - DSC (English) :  2 - 3.12.02  (2 days) AutoCAD 2002 - niveau 2 :  2 & 3.12.02  (2 jours) FileMaker (Français) :  2 - 5.12.02  (4 jours) PCAD Schémas - Débutants :  5 & 6.12.02  (2 jours) PCAD PCB - Débutants :  9 - 11.12.02  (3 jours) FrontPage 2000 - level 1:  9 & 10.12.02  (2 days) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisiona...

  5. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74460

    2001-01-01

    Places are available in the following courses: LabView Base 1 : 27-29.3.01 (3 jours) Contract Follow-up : 9.4.01 (3 heures) Introduction à PowerPoint : 24.4.01 (1 journée) Publier sur le Web : 25-27.4.01 (3 demi-journées) Programmation TSX Premium 2 : 15-16.5.01 (5 jours) LabView Base 2 : 27-29.3.01 (2 jours) Hands-on Object-oriented Analysis, Design & Programming with C++ :  23-27.4.01 (5 days) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt.

  6. [Not Available].

    Science.gov (United States)

    Meyer, J J; Paumard, J L; Milin, D; Levoir, P; Fontaine, J C

    1988-11-01

    A low-cost digital acquisition unit for a CARY-210 spectrophotometer has been designed and constructed. The data-flow is controlled by a 6809 microprocessor driving four parallel interface adapters. Two RS232-C serial links are provided for communication with a terminal and a mass storage unit. The acquired data are processed by a personal computer. Included are several software modules, based on powerful signal-processing algorithms, which are highly useful in kinetic studies.

  7. Investigations of Thickness Requirement in DNV Rules for High-Speed Craft

    DEFF Research Database (Denmark)

    Pedersen, Preben Terndrup; Zhang, Shengming

    1997-01-01

    Simple formulas for determining impact strength of high-speed craft collisions with floating objects are given in this note. Thereby the minimum mass of a floating object that just ruptures the shell plating is predicted. The minimum thickness requirements of DNV rules for aluminiumcrafts and GRP...

  8. What It Takes to Complete High School: The Shifting Terrain of Course and Diploma Requirements

    Science.gov (United States)

    Hoffman, Nancy

    2013-01-01

    In recent months, several states have altered their high school course requirements in various ways, from creating endorsements within a single diploma to creating new diplomas. These states appear to be making changes for a variety of reasons: to elevate career and technical education; to emphasize STEM fields; to improve the alignment with…

  9. [Not Available].

    Science.gov (United States)

    Asfari, Hadyl; Bousquet, Cédric; Paviot, Béatrice Trombert; Bellet, Florelle; Mounier, Geneviève; Marsille, Fakhria; Beyens, Marie-Noëlle; Guy, Claire

    2014-01-01

    To evaluate the value of research in the case-mix database to identify cases of drug-related anaphylactic or anaphylactoid shock. Hospital stays of patients discharged from the University Hospital of Saint-Étienne between July 1st 2009 and June 30th 2012. Five codes from the international classification of diseases were selected: T88.6, T88.2, J39.3, T80.5 and T78.2. Among 89 cases identified by the programme for medicalization of information system (programme de médicalisation des systèmes d'information, PMSI), 40 were selected (45%). Of these, 16 cases were spontaneously reported by physicians. The unspecific code "anaphylactic shock unspecified (T78.2)" was coded for 57.5% of cases. The study confirms the interest of the PMSI as a tool for health monitoring, in addition to spontaneous reporting. Nevertheless, coding with insufficient precision about the causal role of the drug, requires a return to the medical record and so an important time consuming process. Copyright © 2014 Société Française de Pharmacologie et de Thérapeutique. Publié par Elsevier Masson SAS.

  10. 75 FR 17368 - Notice of Availability of an Evaluation of the Highly Pathogenic Avian Influenza Status of Czech...

    Science.gov (United States)

    2010-04-06

    ... the Czech Republic and Sweden with respect to HPAI H5N1. We are making this evaluation available to... Board of Agriculture reported their first case of HPAI H5N1 in domestic poultry to the World Organization of Animal Health (OIE). The outbreak was confirmed in mallard ducks on a game bird breeding farm...

  11. Drought response of five conifer species under contrasting water availability suggests high vulnerability of Norway spruce and European larch

    NARCIS (Netherlands)

    Lévesque, M.; Saurer, M.; Siegwolf, R.; Eilmann, B.; Brang, P.; Bugmann, H.; Rigling, A.

    2013-01-01

    The ability of tree species to cope with anticipated decrease in water availability is still poorly understood. We evaluated the potential of Norway spruce, Scots pine, European larch, black pine, and Douglas-fir to withstand drought in a drier future climate by analyzing their past growth and

  12. [Not Available].

    Science.gov (United States)

    Blanchard, Elodie; de Lara, Manuel Tunon

    2013-01-01

    Pholcodine is an opioid that has been widely used worldwide since 1950 for the treatment of non-productive cough in children and adults. The results of early preclinical studies but also those of recent clinical trials have shown the antitussive efficacy of pholcodine to be superior to that of codeine, of longer duration, and with an equivalent or safer toxicity profile. Also, there is no risk of addiction. Concern had been raised over a possible cross-sensitisation with neuromuscular blocking agents. While a recent assessment of the available data by the European Medicines Agency (EMA) has confirmed the favourable risk-benefit ratio of pholcodine, further studies are needed to clear this point.

  13. [Not Available].

    Science.gov (United States)

    Murray, Clinton K; Bennett, Jason W

    2009-01-01

    Malaria's global impact is expansive and includes the extremes of the healthcare system ranging from international travelers returning to nonendemic regions with tertiary referral medical care to residents in hyperendemic regions without access to medical care. Implementation of prompt and accurate diagnosis is needed to curb the expanding global impact of malaria associated with ever-increasing antimalarial drug resistance. Traditionally, malaria is diagnosed using clinical criteria and/or light microscopy even though both strategies are clearly inadequate in many healthcare settings. Hand held immunochromatographic rapid diagnostic tests (RDTs) have been recognized as an ideal alternative method for diagnosing malaria. Numerous malaria RDTs have been developed and are widely available; however, an assortment of issues related to these products have become apparent. This review provides a summary of RDT including effectiveness and strategies to select the ideal RDT in varying healthcare settings.

  14. [Not Available].

    Science.gov (United States)

    Huguier, Michel; Romestaing, Patrick

    2014-10-01

    In France, the number of students admitted to the second year of medical studies is limited (numerus clausus) by law. In 1971 this limit was first based according to hospital training capacity and subsequently 1979 it has been based on demographic trends. An objective of 250 physicians per 100 000 inhabitants seemed reasonable and required 6 000 students to be trained each year. In 1979, it was decided to restrict the number of students temporarily because of a likely demographic slump after the year 2000. These steps were introduced progressively, in order not to unfairly treat a particular student class. The numerus clausus is also modulated geographically to take into account differences in medical density, as most students set up in the region where they did their medical studies. It is logical to practice preselection for admission to medical school, yet in France every baccalaureat holder can enrol any medical school, and students are totally opposed to preselection. This is why selection takes place at the end of the first year. In the late 1980s, the numerus clausus should have been increased by the health and education ministries, but this was in fact done only ten years later. Estimates of medical demography are complicated by three factors. First, many physicians from European Union member states (mainly Belgium and Romania) practice in France. Second, some students not admitted to the second year of medical studies go to learn medicine in aforeign country before returning to sit the French national examination at the end of the sixth year. Third, public hospitals hire foreign physicians from outside the EU (mainly Algeria and Morocco), who then stay in France permanently. Thus, EU-level decisions are needed to harmonize the medical numerus clausus across member states. The hiring of physicians from non EU countries by French hospitals should be more tightly controlled.

  15. School and District Wellness Councils and Availability of Low-Nutrient, Energy-Dense Vending Fare in Minnesota Middle and High Schools

    Science.gov (United States)

    Kubik, Martha Y.; Lytle, Leslie A.; Farbakhsh, Kian

    2011-01-01

    The Child Nutrition and WIC Reauthorization Act of 2004 required school districts participating in the federal school meals program to establish by the start of the 2006–2007 school year policies that included nutrition guidelines for all foods sold on school campus during the school day and policy development involving key stakeholders. For many schools, policy development was done by wellness councils. This study examined the association between having a wellness council and availability of low-nutrient, energy-dense foods/beverages in school vending machines following enactment of the federal legislation. In 2006–2007, Minnesota middle (n=35) and high (n=54) school principals reported whether their school and district had a wellness council. Trained research staff observed foods/beverages in vending machines accessible to students. Low-nutrient, energy-dense foods/beverages (snacks >3 g fat or >200 calories/serving, and soda, fruit/sport drinks and reduced-fat/whole milk) were grouped into seven categories (eg, high-fat baked goods) and a food score was calculated. Higher scores indicated more low-nutrient, energy-dense vending fare. Multivariate linear regression, adjusted for school characteristics, was used to examine associations between scores and a three-category council variable (district-only; district and school; no council). Among schools, 53% had district-only councils, 38% district and school councils, and 9% had no council. Schools with both a district and school council had a significantly lower mean food score than schools without councils (P=0.03). The potential of wellness councils to impact availability of low-nutrient, energy-dense vending fare is promising. There may be an added benefit to having both a school and district council. PMID:21185978

  16. School and district wellness councils and availability of low-nutrient, energy-dense vending fare in Minnesota middle and high schools.

    Science.gov (United States)

    Kubik, Martha Y; Lytle, Leslie A; Farbakhsh, Kian

    2011-01-01

    The Child Nutrition and WIC Reauthorization Act of 2004 required school districts participating in the federal school meals program to establish by the start of the 2006-2007 school year policies that included nutrition guidelines for all foods sold on school campus during the school day and policy development involving key stakeholders. For many schools, policy development was done by wellness councils. This study examined the association between having a wellness council and availability of low-nutrient, energy-dense foods/beverages in school vending machines following enactment of the federal legislation. In 2006-2007, Minnesota middle (n=35) and high (n=54) school principals reported whether their school and district had a wellness council. Trained research staff observed foods/beverages in vending machines accessible to students. Low-nutrient, energy-dense foods/beverages (snacks >3 g fat or >200 calories/serving, and soda, fruit/sport drinks and reduced-fat/whole milk) were grouped into seven categories (eg, high-fat baked goods) and a food score was calculated. Higher scores indicated more low-nutrient, energy-dense vending fare. Multivariate linear regression, adjusted for school characteristics, was used to examine associations between scores and a three-category council variable (district-only; district and school; no council). Among schools, 53% had district-only councils, 38% district and school councils, and 9% had no council. Schools with both a district and school council had a significantly lower mean food score than schools without councils (P=0.03). The potential of wellness councils to impact availability of low-nutrient, energy-dense vending fare is promising. There may be an added benefit to having both a school and district council.

  17. Claudin-1 required for HCV virus entry has high potential for phosphorylation and O-glycosylation

    Directory of Open Access Journals (Sweden)

    Fouzia Kiran

    2011-05-01

    Full Text Available Abstract HCV is a leading cause of hepatocellular carcinoma and cirrhosis all over the world. Claudins belong to family of tight junction's proteins that are responsible for establishing barriers for controlling the flow of molecules around cells. For therapeutic strategies, regulation of viral entry into the host cells holds a lot of promise. During HCV infection claudin-1 is highly expressed in liver and believed to be associated with HCV virus entry after HCV binding with or without co-receptor CD81. The claudin-1 assembly with tight junctions is regulated by post translational modifications. During claudins assembly and disassembly with tight junctions, phosphorylation is required at C-terminal tail. In cellular proteins, interplay between phosphorylation and O-β-GlcNAc modification is believed to be functional switch, but it is very difficult to monitor these functional and vibrant changes in vivo. Netphos 2.0 and Disphos 1.3 programs were used for potential phosphorylation; NetPhosK 1.0 and KinasePhos for kinase prediction; and YinOYang 1.2 and OGPET to predict possible O-glycosylation sites. We also identified Yin Yang sites that may have potential for O-β-GlcNAc and phosphorylation interplay at same Ser/Thr residues. We for the first time proposed that alternate phosphorylation and O-β-GlcNAc modification on Ser 192, Ser 205, Ser 206; and Thr 191 may provide an on/off switch to regulate assembly of claudin-1 at tight junctions. In addition these phosphorylation sites may be targeted by novel chemotherapeutic agents to prevent phosphorylation lead by HCV viral entry complex.

  18. Highly precise and developmentally programmed genome assembly in Paramecium requires ligase IV-dependent end joining.

    Directory of Open Access Journals (Sweden)

    Aurélie Kapusta

    2011-04-01

    Full Text Available During the sexual cycle of the ciliate Paramecium, assembly of the somatic genome includes the precise excision of tens of thousands of short, non-coding germline sequences (Internal Eliminated Sequences or IESs, each one flanked by two TA dinucleotides. It has been reported previously that these genome rearrangements are initiated by the introduction of developmentally programmed DNA double-strand breaks (DSBs, which depend on the domesticated transposase PiggyMac. These DSBs all exhibit a characteristic geometry, with 4-base 5' overhangs centered on the conserved TA, and may readily align and undergo ligation with minimal processing. However, the molecular steps and actors involved in the final and precise assembly of somatic genes have remained unknown. We demonstrate here that Ligase IV and Xrcc4p, core components of the non-homologous end-joining pathway (NHEJ, are required both for the repair of IES excision sites and for the circularization of excised IESs. The transcription of LIG4 and XRCC4 is induced early during the sexual cycle and a Lig4p-GFP fusion protein accumulates in the developing somatic nucleus by the time IES excision takes place. RNAi-mediated silencing of either gene results in the persistence of free broken DNA ends, apparently protected against extensive resection. At the nucleotide level, controlled removal of the 5'-terminal nucleotide occurs normally in LIG4-silenced cells, while nucleotide addition to the 3' ends of the breaks is blocked, together with the final joining step, indicative of a coupling between NHEJ polymerase and ligase activities. Taken together, our data indicate that IES excision is a "cut-and-close" mechanism, which involves the introduction of initiating double-strand cleavages at both ends of each IES, followed by DSB repair via highly precise end joining. This work broadens our current view on how the cellular NHEJ pathway has cooperated with domesticated transposases for the emergence of new

  19. High energy SEU test results for the commercially available MIPS R3000 microprocessor and R3010 floating point unit

    Energy Technology Data Exchange (ETDEWEB)

    Shaeffer, D.L.; Kimbrough, J.R.; Denton, S.M.; Kaschimitter, J.L.; Wilburn, J.W.; Davis, R.W.; Colella, N.J. (Lawrence Livermore National Lab., CA (United States)); Holtkamp, D.B. (Los Alamos National Lab., NM (United States))

    1991-08-15

    Single event upset (SEU) cross sections and total dose hardness of commercially available MIPS R3000 microprocessors (CPU) and R3010 floating point units (FPU) were obtained by exposing these parts to 256 MeV protons from the linear accelerator (LINAC) at the Los Alamos Meson Physics Facility (LAMPF). Parts from several manufacturers were tested. The CPUs and FPUs were tested dynamically during radiation exposure with specially designed assembly language codes which exercised a subset of the available instructions in order to simulate the actual operation of each part. Cross sections derived from the SEU data were used to calculate expected upset rate for a 500-km orbit during quiet solar conditions, the King 1972 solar flare, and the August 4, 1972, event modeled by Adams et al. 16 refs., 16 figs., 3 tabs.

  20. High energy proton SEU test results for the commercially available MIPS R3000 microprocessor and R3010 floating point unit

    Energy Technology Data Exchange (ETDEWEB)

    Shaeffer, D.L.; Kimbrough, J.R.; Denton, S.M.; Kaschmiter, J.L.; Wilburn, J.W.; Davis, R.W.; Colella, N.J. (Lawrence Livermore National Lab., CA (United States)); Holtkamp, D.B. (Los Alamos National Lab., NM (United States))

    1991-12-01

    This paper reports on proton single event upset (SEU) cross sections and proton total dose hardness of commercially available MIPS R3000 microprocessors (CPU) and R3010 floating point units (FPU) that were obtained by exposing these parts to 256 MeV protons from the linear accelerator (LINAC) at the Los Alamos Meson Physics Facility (LAMPF). Parts from several manufacturers were tested. The CPUs and FPUs were tested dynamically during radiation exposure with specially designed assembly language codes which exercised a subset of the available instructions. Cross sections derived from the SEU data were used to calculate expected upset rates for a 500-km, 60-degree inclination, orbit during quiet solar conditions and during the August 4, 1972, King solar flare event.

  1. Optimising power plant operation - high availability at low maintenance costs; Optimierung des Kraftwerksbetriebs - hohe Verfuegbarkeit trotz geringer Instandhaltungskosten

    Energy Technology Data Exchange (ETDEWEB)

    Kienreich, A.; Maagh, P.; Gilow, C.; Suerig, C.; Vahlenkamp, T. [McKinsey and Co., Inc., Duesseldorf (Germany)

    2008-01-15

    Most power plant operators responded to the liberalisation of the European energy markets by lowering their costs. The measures they took to this end such as lengthening maintenance intervals, cutting down on operating staff and progressively outsourcing maintenance services have indeed had an impact, albeit not as intended. In the meantime some power plants are showing first signs of impaired availability and reliability, both of which criteria had begun to play a more prominent role again in recent years. Today's challenge on power supply companies therefore is to optimise the costs and availability of their plants simultaneously. The ''McKinsey Power Gauge'', a Europe-wide benchmarking system provides assistance in identifying successful operating and maintenance strategies.

  2. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: LabVIEW base 1 : 22 - 24.4.02 (3 jours) CLEAN 2002 : working in a cleanroom:  24.4.02  (half-day, pm) LabVIEW DSC (F) 25 & 26.4.02 (2 jours) AutoCAD : Mise à jour AutoCAD r-14 vers 2002 : 25 & 26.4.02 (2 jours) Cotations selon les normes GPS de l'ISO : 29 - 30.4.02 (2 jours) Introduction to the CERN Engineering Data Management System:  7.5.02  (1 day) LabVIEW Basics 2: 13 & 14.5.02 (2 days) AutoCAD Mechanical 6 PowerPack (F) : 13-14, 17, 21, 27-28.5.02 (6 jours) WorldFIP - Généralités : 14.5.2002 (1/2 journée) WorldFIP - Développer avec MicroFIP HANDLER : 14.5 - après-midi, 15.5.02 - matin (1 jour) WorldFIP - FullFIP FDM : FIP Device Manager (F) : 15.5 - après-midi, 16.5.02 - matin (1 jour) LabVIEW DAQ (F) : 15 & 16.5.02 (2 jours) EXCEL 2000 - niveau 2 : 22 & 23.5.02 (2 jours)...

  3. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: The CERN Engineering Data Management System for Advanced users : 16.4.02  (1 day) Migration from AutoCAD 14 towards AutoCAD Mechanical6 PowerPack:  17 - 19.4 and 2 &3.5.02  (5 days) AutoCAD - niveau 1 : 22, 23, 29, 30.4 et 6, 7.5.02 (6 jours) LabVIEW base 1 : 22 - 24.4.02 (3 jours) CLEAN 2002 : working in a cleanroom:  24.4.02  (half-day, pm) LabVIEW DSC (F) 25 & 26.4.02 (2 jours) AutoCAD : Mise à jour AutoCAD r-14 vers 2002 : 25 & 26.4.02 (2 jours) Cotations selon les normes GPS de l'ISO : 29 - 30.4.02 (2 jours) Introduction to the CERN Engineering Data Management System:  7.5.02  (1 day) LabVIEW Basics 2: 13 & 14.5.02 (2 days) AutoCAD Mechanical 6 PowerPack (F) : 13-14, 17, 21, 27-28.5.02 (6 jours) WorldFIP - Généralités : 14.5.2002 (1/2 journée) WorldFIP - Développer avec Micr...

  4. Places available **

    CERN Multimedia

    2003-01-01

    Des places sont disponibles dans les cours suivants : Places are available in the following courses : WorldFIP 2003 pour utilisateurs : 11-14.2.03 (4 jours) DISP-2003 ? Spring I Term : Introduction to Digital Signal Processing : 20, 27.2, 6, 13, 20, 27.3, 3.4.03 (7 X 2-hour lectures) AXEL-2003 - Introduction to Accelerators : 24-28.2.03 (10 X 1-hour lectures) AutoCAD 2002 - niveau 1 : 24, 25.2 & 3, 4.3.03 (4 jours) Introduction à Windows 2000 au CERN : 25.2.03 (1/2 journée) LabView base 2/LabView Basics 2 : 10 & 11.3.03 (2 jours/2 days) langue à définir/Language to be decided C++ for Particle Physicists : 10 ? 14.3.03 (6 X 3-hour lectures) Introduction to PVSS : 10.3.03 (half day, afternoon) Basic PVSS : 11 - 13.3.03 (3 days) LabView avancé /LabView Advanced : 12 - 14.3.03 (3 jours/3days) Langue à définir/language to be decided AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 17, 18, 24 & 25.3.03 (6 jours) PVSS - JCOP Framework Tutorial : 14.3.03 (1 day) MAGNE-03 - Magnetism for Technical Ele...

  5. Places available **

    CERN Multimedia

    2003-01-01

    Des places sont disponibles dans les cours suivants : Places are available in the following courses : DISP-2003 - Spring I Term : Introduction to Digital Signal Processing : 20, 27.2, 6, 13, 20, 27.3, 3.4.03 (7 X 2-hour lectures) AXEL-2003 - Introduction to Accelerators : 24 - 28.2.03 (10 X 1-hour lectures) AutoCAD 2002 - niveau 1 : 24, 25.2 & 3, 4.3.03 (4 jours) Introduction à Windows 2000 au CERN : 25.2.03 (1/2 journée) LabView base 2/LabView Basics 2 : 10 & 11.3.03 (2 jours/2 days) langue à définir/Language to be decided C++ for Particle Physicists : 10 - 14.3.03 (6 X 3-hour lectures) Introduction to PVSS : 10.3.03 (half day, afternoon) Basic PVSS : 11 - 13.3.03 (3 days) LabView avancé /LabView Advanced : 12 - 14.3.03 (3 jours/3days) Langue à définir/language to be decided AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 17, 18, 24 & 25.3.03 (6 jours) PVSS - JCOP Framework Tutorial : 14.3.03 (1 day) CLEAN-2002 : Working in a cleanroom : 2.4.03 (half-day, afternoon, free course, regis...

  6. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Automates et réseaux de terrain : 13 & 14.11.01 (3 jours) Introduction à Windows 2000 au CERN : 12 - 14.11.01 (1/2 journée) Introduction to Windows 2000 at CERN :  14.11.01  (half-day) Introduction to PERL 5 :  15 - 16.11.01  (2 days) Sécurité dans les installations cryogéniques : 21 - 22.11.2001 (2 demi-journées) Introduction to C Programming :  21- 23.11.01 (3 days) Programmation TSX Premium 2 : 26 - 30.11.01 (5 jours) Contract Follow-up (F) : 26.11.01 (1/2 journée) Object-Oriented Analysis and Design :  27 - 30.11.2001  (4 days) Introduction to the CERN Engineering Data Management System :  30.11.2001 (1 day) Electromagnetic Compatibility (EMC): Introduction (bilingual) :  3.12.01 (half-day) Introduction to the CERN Engineering Data Management System : 07.12.2001...

  7. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: October 2002   Introduction to the CERN Engineering Data Management System (free of charge):  29.10.2002  (1 day) The CERN EDMS for Advanced users (free of charge):  30.10.2002  (1 day) November 2002   LabView hands-on (bilingue/bilingual): 5.11.02 (matin/morning) LabView DAQ hands-on (bilingue/bilingual):  5.11.02  (après-midi afternoon) Introduction au PC et Windows 2000 au CERN :  6 & 7.11.02  (2 jours) Oracle 8i : Access the Database with Java:  7 & 8.11.02  (2 days) AutoCAD 2002 - niveau 2 :  7 & 8.11.02  (2 jours) Introduction to PVSS (free of charge):  11.11.2002 pm  (1/2 day) Basic PVSS:  12 - 14.11.02  (3 days) EXCEL 2000 - niveau 1 :  12 & 13.11.02  (2 jours) CLEAN-2002: Working in a Cleanroom (English, free ...

  8. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Contract Follow-up (F) : 30.10.01 (1/2 journée) The CERN Engineering Data Management System for Electronics Design :  30.10.01 (1 day) Nouveautés d'Excel 2000 : 5.11.01 (1/2 journée) UNIX pour non-programmeurs : 5 - 7.11.01 (3 jours) Introduction à Windows 2000 au CERN : 6.11.01 (1/2 journée) The Java programming language Level 1: 8 - 9.11.01 (2 days) LabView Base 1 : 12 - 14.11.01 (3 jours) LabVIEW DAQ (F) : 15 & 16.11.01 (2 jours) Automates et réseaux de terrain : 13 & 14.11.01 (2 jours) Introduction to PERL 5 :  15 - 16.11.01  (2 days) LabVIEW - DAQ : 15 - 16.11.01 (2 jours) Introduction to XML :  19 - 20.11.01 (2 days) Introduction to C Programming :  21- 23.11.01 (3 days) Programmation TSX Premium 2 : 26 - 30.11.01 (5 jours) Object-Oriented Analysis and Design :  27 - 30.11.2001 (4 days) Hands...

  9. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: ELEC-2002 : Spring Term :  9, 11, 16, 18, 23, 25, 30.4.02 (7 * 2.5 hours) Object-Oriented Analysis & Design: 16 - 19.4.02  (4 days) The CERN Engineering Data Management System for Advanced users:  16.4.02  (1 day) Migration from AutoCAD 14 towards AutoCAD Mechanical6 PowerPack:  17 - 19.4 and 2 &3.5.02  (5 days) AutoCAD - niveau 1 : 22, 23, 29, 30.4 et 6, 7.5.02 (6 jours) LabVIEW base 1 : 22 - 24.4.02 (3 jours) CLEAN 2002 : working in a cleanroom:  24.4.02  (half-day, pm) LabVIEW DSC (F) 25 & 26.4.02 (2 jours) AutoCAD : Mise à jour AutoCAD r-14 vers 2002 : 25 & 26.4.02 (2 jours) LabVIEW Basics 2 : 13 & 14.5.02 (2 days) EXCEL 2000 - niveau 1 : 15 & 16.5.02 (2 jours) LabVIEW DAQ (F) : 15 & 16.5.02 (2 jours) EXCEL 2000 - niveau 2 : 22 & 23.5.02 (2 jours) LabVIEW Basics 1:  3 - 5.6.02&a...

  10. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: ELEC-2002 : Spring Term :  9, 11, 16, 18, 23, 25, 30.4.02 (7 * 2.5 hours) Object-Oriented Analysis & Design: 16 - 19.4.02  (4 days) The CERN Engineering Data Management System for Advanced users:  16.4.02  (1 day) Migration from AutoCAD 14 towards AutoCAD Mechanical6 PowerPack:  17 - 19.4 and 2 &3.5.02  (5 days) AutoCAD - niveau 1 : 22, 23, 29, 30.4 et 6, 7.5.02 (6 jours) LabVIEW base 1 : 22 - 24.4.02 (3 jours) CLEAN 2002 : working in a cleanroom:  24.4.02  (half-day, pm) LabVIEW DSC (F) 25 & 26.4.02 (2 jours) AutoCAD : Mise à jour AutoCAD r-14 vers 2002 : 25 & 26.4.02 (2 jours) Cotations selon les normes GPS de l'ISO : 29 - 30.4.02 (2 jours) Introduction to the CERN Engineering Data Management System:  7.5.02  (1 day) LabVIEW Basics 2 : 13 & 14.5.02 (2 days) AutoCAD Mechanical 6 PowerPack (F) : 13-...

  11. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Introduction to C Programming :  21- 23.11.01 (3 days) Programmation TSX Premium 2 : 26 - 30.11.01 (5 jours) Contract Follow-up (F) : 26.11.01 (1/2 journée) Habilitation électrique : électriciens network : 27 - 29.11.2001 (3 jours) Object-Oriented Analysis and Design :  27 - 30.11.2001  (4 days) Introduction to the CERN Engineering Data Management System :  30.11.2001 (1 day) Electromagnetic Compatibility (EMC): Introduction (bilingual) :  3.12.01 (half-day) Introduction to the CERN Engineering Data Management System : 07.12.2001 (1 day) LabVIEW - Basics 1 :  10 - 12.12.01 (3 days) LabVIEW - Basics 2 :  13 - 14.12.01 (2 days) EXCEL 2000 - niveau 2 : 15 - 16.1.02 (2 jours) C++ Programming Level 2 - Traps and Pitfalls :  15 - 18.1.2002  (4 days) Nouveautés de WORD 2000 : 18.1.02 (1/2 journée) FileMaker P...

  12. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : DISP-2003 - Spring II Term : Advanced Digital Signal Processing : 30.4, 7, 14, 21.5.03 (4 X 2-hour lectures) Programmation de pilotes périphériques : 5 - 8.5.03 (4 jours) Oracle iDS Reports : Build Internet Reports : 5 - 9.5.03 (5 days) LabView DAQ (language to be defined) : 8 & 9.5.03 AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 20, 21, 27 & 28.5.0 (6 jours) FrontPage 2000 - niveau 1 : 20 & 21.5.03 (2 jours) AutoCAD 2002 - niveau 2 : 3 & 4.6.03 (2 jours) EXCEL 2000 - niveau 1 : 10 & 11.6.03 (2 jours) EXCEL 2000 - level 1 : 12 & 13.6.03 (2 days) PowerPoint 2000 (F) : 17 & 18.6.03 (2 jours) FrontPage 2000 - niveau 2 : 19 & 20.6.03 (2 jours) LabView DSC (langue à décider/language to be defined) : 19 & 20.6.03 EXCEL 2000 - niveau 2 : 24 & 25.6.03 (2 jours) Siemens SIMATIC Training : Introduction to STEP7 : 3 & 4.6.03 (2 days) STEP7 Programming : 16 - 20.6.03 (5 days) Simatic Net Network : 26 & 27.6.03 ...

  13. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : DISP-2003 - Spring II Term : Advanced Digital Signal Processing : 30.4, 7, 14, 21.5.03 (4 X 2-hour lectures) Oracle iDS Reports : Build Internet Reports : 5 - 9.5.03 (5 days) LabView DAQ (language to be defined) : 8 & 9.5.03 AutoCAD Mechanical 6 PowerPack (F) : 12, 13, 20, 21, 27 & 28.5.03 (6 jours) AutoCAD 2002 - niveau 2 : 3 & 4.6.03 (2 jours) LabView DSC (language to be defined) : 19 & 20.6.03 Siemens SIMATIC Training : Introduction to STEP7 : 3 & 4.6.03 (2 days) STEP7 Programming : 16 - 20.6.03 (5 days) Simatic Net Network : 15 & 16.4.03 / 26 & 27.6.03 (sessions of 2 days) These courses will be given in French or English following the requests. Cours de sécurité : Etre TSO au CERN : Prochaines sessions : 24, 25 & 27.6.03 - 4, 5 & 7.11.03 (session de 3 jours) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description ...

  14. [Not Available].

    Science.gov (United States)

    Calbiac, Pascale De; Lamoureux, Fabien; Pourrat, Xavier; Bretault, Lydia; Marchand, Sophie; Grassin, Jacqueline; Antier, Daniel

    2006-01-01

    Treatment of Bronchial Superinfections: Data Related to Stability of Antibiotics in Portable Pumps. Given many data about the stability of antibiotics in portable pump (elastomer) are lacking, this study was designed to make a point about available data and to evaluate the stability of antibiotics when exposed to temperature within 35°C (average temperature measured in real conditions of use). First, to collect information about the stability of antibiotics in portable pump and to confront them with the local antibiotics protocols dedicated to the treatment of bronchial superinfection in patients with cystic fibrosis; second, to evaluate the stability of piperacillin associated with tazobactam at 35°C. While measured concentrations in tazobactam did not show significant variation during the study, piperacillin measurements showed a major reduction of concentration (up to 33%), both time and concentration related to. Such information must be pointed out to prescribers and patients to ensure a cold accumulator is placed in the pump can'ying-bag and to limit the duration of infusion to 24h with a single pump. This experimental program will keep on going with the stability study of both ticarcillin and cefsulodin in portable pump. Copyright © 2006 Société Française de Pharmacologie et de Thérapeutique. Publié par Elsevier Masson SAS.

  15. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: Introduction au PC et à Windows 2000 au CERN : 29 - 30.1.02 (2 jours) LabView Base 1 : 4 - 6.2.02 (3 jours) LabView DAQ  (F) : 7 & 8.2.02 (2 jours) Hands-on Object-Oriented Design & Programming with Java :  11 - 13.02.02 (3 days) PVSS basics :  18 - 22.2.02 (5 days) Introduction à Windows 2000 : 18.2.02 (1 demi-journée) Introduction to the CERN Engineering Data Management System :  20.2.02 (1 day) The CERN Engineering Data Management System for Advanced users :  21.2.02  (1 day) C++ for Particle Physicists :  11 - 15.3.2002  (6 * 3 hour lectures) Cours sur la migration AutoCAD : AutoCAD : Mise à jour AutoCAD r-14 vers 2002 (2 jours) AutoCAD Mechanical PowerPack 6 basé sur AutoCAD 2002 (5 jours) If you wish to participate in one of these courses, please discuss with your supervisor and apply electr...

  16. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: C++ for Particle Physicists :  11 - 15.3.2002  (6 * 3 hour lectures) Programming the Web for Control Applications : 11, 12, 18, 19.3.2002  (4 * 2 hour lectures) Habilitation électrique : recyclage HT/BT (Français) : 13 - 14.3.2002 (2 * 2 heures) Introduction à la CAO CADENCE : 19 & 20.3.02 (2 jours) LabVIEW base 1 : 22 - 24.4.02 (3 jours) LabVIEW DSC (F) 25 & 26.4.02 (2 jours) LabVIEW Basics 2 : 13 & 14.5.02 (2 days) LabVIEW DAQ (F) : 15 & 16.5.02 (2 jours) Cours sur la migration AutoCAD :   AutoCAD : Mise à jour AutoCAD r-14 vers 2002 (2 jours) AutoCAD Mechanical PowerPack 6 basé sur AutoCAD 2002 (5 jours) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : Technical Training or fil...

  17. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: LabVIEW - Basics 1 :  10 - 12.12.01 (3 days) Introduction to XML :  12 & 13.12.01 (2 days) Introduction au PC et Windows 2000 : 12 & 14.12.01 (2 jours) LabVIEW - Basics 2 :  13 - 14.12.01 (2 days) Habilitation électrique : superviseurs : 17.12.2001 (1/2 journée) MS-Project 2000 : 10 & 11.01.02 (2 jours) EXCEL 2000 - niveau 2 : 15 - 16.1.02 (2 jours) Sécurité dans les installations cryogéniques: 15-17.1.2002 (2 demi-journées) C++ Programming Level 2 - Traps and Pitfalls :  15 - 18.1.2002  (4 days) ELEC-2002 Winter Term: Readout and system electronics for Physics  15.1.2002 - 7.2.2002 (8 half- days) Nouveautés de WORD 2000 : 18.1.02 (1/2 journée) LabView hands-on : 21.01.02 (1/2 journée) LabView DAQ hands-on : 21.01.02 (1/2 journée) FileMaker Pro : 22 -...

  18. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2002-01-01

    Places are available in the following courses: LabView hands-on : 21.01.02 (1/2 journée) LabView DAQ hands-on : 21.01.02 (1/2 journée) FileMaker Pro : 22 - 25.1.02 (4 jours) MS-Project 2000 : 22, 24 & 25.01.02 (3 jours) Introduction au PC et à Windows 2000 au CERN : 29 - 30.1.02 (2 jours) LabView Base 1 : 4 - 6.2.02 (3 jours) LabView DAQ  (E) :  7 & 8.02.02 (2 days) Hands-on Object-Oriented Design & Programming with Java :  11 - 13.02.02 (3 days) PVSS basics :  11 - 15.2.02 (5 days) Introduction à Windows 2000 : 18.2.02 (1 demi-journée) Introduction to the CERN Engineering Data Management System :  20.2.02 (1 day) The CERN Engineering Data Management System for Advanced users :  21.2.02  (1 day) C++ for Particle Physicists :  11 - 15.3.2002  (6 * 3 hour lectures) Cours sur la migration AutoCAD : AutoCAD : Mise à...

  19. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel.74924

    2001-01-01

    Places are available in the following courses: Habilitation électrique : superviseurs : 5.12.01 (1/2 journée) LabVIEW - Basics 1 :  10 - 12.12.01 (3 days) Introduction au PC et Windows 2000 : 12 & 14.12.01 (2 jours) LabVIEW - Basics 2 :  13 - 14.12.01 (2 days) Habilitation électrique : superviseurs : 17.12.2001 (1/2 journée) EXCEL 2000 - niveau 2 : 15 - 16.1.02 (2 jours) Sécurité dans les installations cryogéniques: 15-17.1.2002 (2 demi-journées) C++ Programming Level 2 - Traps and Pitfalls :  15 - 18.1.2002  (4 days) ELEC-2002 Winter Term: Readout and system electronics for Physics  15.1.2002 - 7.2.2002 (8 half- days) Nouveautés de WORD 2000 : 18.1.02 (1/2 journée) LabView hands-on : 21.01.02 (1/2 journée) LabView DAQ hands-on : 21.01.02 (1/2 journée) FileMaker Pro : 22 - 25.1.02 (4 jours) Frontpage...

  20. PLACES AVAILABLE

    CERN Multimedia

    Enseignement Technique; Tel. 74924

    2001-01-01

    Places are available in the following courses: MS-Project 2000 : 10 & 11.01.02 (2 jours) EXCEL 2000 - niveau 2 : 15 - 16.1.02 (2 jours) Sécurité dans les installations cryogéniques: 15-17.1.2002 (2 demi-journées) C++ Programming Level 2 - Traps and Pitfalls :  15 - 18.1.2002  (4 days) ELEC-2002 Winter Term: Readout and system electronics for Physics  15.1.2002 - 7.2.2002 (8 half- days) Nouveautés de WORD 2000 : 18.1.02 (1/2 journée) LabView hands-on : 21.01.02 (1/2 journée) LabView DAQ hands-on : 21.01.02 (1/2 journée) FileMaker Pro : 22 - 25.1.02 (4 jours) MS-Project 2000 : 24 & 25.01.02 (2 jours) Introduction au PC et à Windows 2000 au CERN : 29 - 30.1.02 (2 jours) LabView Base 1 : 4 - 6.2.02 (3 jours) LabView DAQ  (E) :  7 & 8.02.02 (2 days) Hands-on Object-Oriented Design & Programming with Java :&nbs...

  1. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: PVSS Basics :  8 - 12.4.02  (5 days) AutoCAD : Mise à jour AutoCAD r-14 vers 2002 : 25 & 26.4.02 (2 jours) ELEC-2002 : Spring Term :  9, 11, 16, 18, 23, 25, 30.4.02 (7 * 2.5 hours) Object-Oriented Analysis & Design: 16 - 19.4.02  (4 days) Migration from AutoCAD 14 towards AutoCAD Mechanical6 PowerPack:  17 - 19.4 and 2 &3.5.02  (5 days) LabVIEW base 1 : 22 - 24.4.02 (3 jours) LabVIEW DSC (F) 25 & 26.4.02 (2 jours) LabVIEW Basics 2 : 13 & 14.5.02 (2 days) EXCEL 2000 - niveau 2 : 22 & 23.5.02 (2 jours) LabVIEW DAQ (F) : 15 & 16.5.02 (2 jours) LabVIEW Basics 1:  3 - 5.6.02  (3 days) LabVIEW DAQ (E):  6 & 7.6.02  (2 days) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that...

  2. PLACES AVAILABLE

    CERN Multimedia

    Monique DUVAL

    2002-01-01

    Places are available in the following courses: LabView Basics 1 :  4 - 6.3.02  (3 days) CLEAN-2002 : Working in a Clean Room :  7.3.2002  (half day) LabView Base 2 : 11 & 12.3.02 (2 jours) C++ for Particle Physicists :  11 - 15.3.2002  (6 * 3 hour lectures) Programming the Web for Control Applications : 11, 12, 18, 19.3.2002  (4 * 2 hour lectures) Habilitation électrique : recyclage HT/BT (Français) : 13 - 14.3.2002 (2 * 2 heures) LabView Advanced :  13 - 15.3.02 (3 days) Introduction to the CERN Engineering Data Management System (EDMS) :  20.3.2002  (1 day) The CERN (EDMS) for Advanced Users :  21.3.2002  (1 day) LabVIEW DSC : 25 - 26.4.2002 (2 jours) LabVIEW DAQ : 15 - 16.5.2002 (2 jours) Cours sur la migration AutoCAD :   AutoCAD : Mise à jour AutoCAD r-14 vers 2002 (2 jours) AutoCAD Mechanical PowerPack 6 basé ...

  3. PLACES AVAILABLE

    CERN Multimedia

    Technical Traininf; Tel. 74924

    2001-01-01

    Places are available in the following courses: Electromagnetic Compatibility (EMC): Introduction (bilingual) :  3.12.01 (half-day) Habilitation électrique : superviseurs : 5.12.01 (1/2 journée) Introduction to the CERN Engineering Data Management System : 07.12.2001 (1 day) LabVIEW - Basics 1 :  10 - 12.12.01 (3 days) Introduction au PC et Windows 2000 : 12 & 14.12.01 (2 jours) LabVIEW - Basics 2 :  13 - 14.12.01 (2 days) Habilitation électrique : superviseurs : 17.12.2001 (1/2 journée) EXCEL 2000 - niveau 2 : 15 - 16.1.02 (2 jours) C++ Programming Level 2 - Traps and Pitfalls :  15 - 18.1.2002  (4 days) Nouveautés de WORD 2000 : 18.1.02 (1/2 journée) LabView hands-on : 21.01.02 (1/2 journée) LabView DAQ hands-on : 21.01.02 (1/2 journée) FileMaker Pro : 22 - 25.1.02 (4 jours) Introduction au PC et à Windows 2000 au CERN : 29 - 30.1....

  4. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : FrontPage 2000 - niveau 1 : 20 & 21.5.03 (2 jours) PIPES-2003 : Pratique du sertissage de tubes métalliques et multicouches : 21.5.03 (1 jour) Introduction à la CAO Cadence : de la saisie de schéma Concept-HDL au PCB : 20 & 22.5.03 (2 jours) AutoCAD 2002 - niveau 2 : 3 & 4.6.03 (2 jours) AutoCAD Mechanical 6 PowerPack (F) : 5, 6, 12, 13, 26, 27.6.03 (6 jours) EXCEL 2000 - niveau 1 : 10 & 11.6.03 (2 jours) Conception de PCB rapides dans le flot Cadence : 11.6.03 (matin) EXCEL 2000 - level 1 : 12 & 13.6.03 (2 days) PowerPoint 2000 (F) : 17 & 18.6.03 (2 jours) Réalisation de PCB rapides dans le flot Cadence : 17.6.03 (matin) FrontPage 2000 - niveau 2 : 19 & 20.6.03 (2 jours) LabView DSC (langue à décider/language to be defined) : 19 & 20.6.03 EXCEL 2000 - niveau 2 : 24 & 25.6.03 (2 jours) Siemens SIMATIC Training: Introduction to STEP7 : 3 & 4.6.03 (2 days) STEP7 Programming : 16 - 20.6.03 (5 days) Simatic...

  5. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : FrontPage 2000 - niveau 1: 20 & 21.5.03 (2 jours) PIPES-2003 : Pratique du sertissage de tubes métalliques et multicouches: 21.5.03 (1 jour) Introduction à la CAO Cadence: de la saisie de schéma Concept-HDL au PCB : 20 & 22.5.03 (2 jours) AutoCAD Mechanical 6 PowerPack (E): 5, 6, 12, 13, 26, 27.6.03 (6 days) EXCEL 2000 - niveau 1: 10 & 11.6.03 (2 jours) Conception de PCB rapides dans le flot Cadence: 11.6.03 (matin) EXCEL 2000 - level 1: 12 & 13.6.03 (2 days) Introduction to PVSS: 16.6.03 (half-day, pm) Basic PVSS: 17 - 19.6.03 (3 days) Réalisation de PCB rapides dans le flot Cadence: 17.6.03 (matin) LabView DSC (language to be defined): 19 & 20.6.03 PVSS - JCOP Framework Tutorial: 20.6.03 (1 day) EXCEL 2000 - niveau 2: 24 & 25.6.03 (2 jours) Siemens SIMATIC Training: Introduction to STEP7: 3 & 4.6.03 (2 days) STEP7 Programming: 16 - 20.6.03 (5 days) Simatic Net Network: 26 & 27.6.03 (2 days) These courses will be given...

  6. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: EXCEL 2000 - niveau 1 : 3 et 4.10.01 (2 jours) Automates et réseaux de terrain : 3 - 4.10.2001 (2 jours) Introduction à Outlook : 5.10.01 (1 journée) C++ for Particle Physicists : 8 - 12.10.01 (6 lectures) Cadence Board Design tools : Upgrading to release 14 : 3 1-day sessions on 9, 10 & 11.10.01 MS-Project 2000 - niveau 1 : 15 - 18.10.01 (4 demi-journées) LabView Base 2 : 18 & 19.10.01 (2 jours) WORD 2000 : importer et manipuler des images : 19.10.01 (1 journée) The CERN Engineering Data Management System for Electronics Design :  30.10.01 (1 day) UNIX pour non-programmeurs : 5 - 7.11.01 (3 jours) The Java programming language Level 1: 8 - 9.11.01 (2 days) Introduction to PERL 5 :  15 - 16.11.01  (2 days) Introduction to XML :  19 - 20.11.01 (2 days) Programming TSX Premium 1 :  19 - 23.11.01  (5 days) Introd...

  7. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Contract Follow-up (F) : 30.10.01 (1/2 journée) The CERN Engineering Data Management System for Electronics Design :  30.10.01 (1 day) UNIX pour non-programmeurs : 5 - 7.11.01 (3 jours) Nouveautés d'EXCEL : 5.11.01 (1/2 journée) Introduction a Windows 2000 au CERN : 6.11.01 (1/2 journée) The Java programming language Level 1: 8 - 9.11.01 (2 days) LabView Base 1 : 12 - 14.11.01 (3 jours) Automates et réseaux de terrain : 13 & 14.11.01 (2 jours) Introduction to PERL 5 :  15 - 16.11.01  (2 days) Introduction to XML :  19 - 20.11.01 (2 days) Programming TSX Premium 1 :  19 - 23.11.01  (5 days) Introduction to C Programming :  21- 23.11.01 (3 days) The Java programming language Level 2:  26 - 28.11.01 (3 days) Programmation TSX Premium 2 : 26 - 30.11.01 (5 jours) Autocad Migration support courses: a detail...

  8. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: MS-Project 2000 - niveau 1 : 15 - 18.10.01 (4 demi-journées) LabView Base 2 : 18 & 19.10.01 (2 jours) WORD 2000 : importer et manipuler des images : 19.10.01 (1 journée) Contract Follow-up (F) : 30.10.01 (1/2 journée) The CERN Engineering Data Management System for Electronics Design :  30.10.01 (1 day) UNIX pour non-programmeurs : 5 - 7.11.01 (3 jours) The Java programming language Level 1: 8 - 9.11.01 (2 days) LabView Base 1 : 12 - 14.11.01 (3 jours) Automates et réseaux de terrain : 13 & 14.11.01 (2 jours) Introduction to PERL 5 :  15 - 16.11.01  (2 days) Introduction to XML :  19 - 20.11.01 (2 days) Programming TSX Premium 1 :  19 - 23.11.01  (5 days) Introduction to C Programming :  21- 23.11.01 (3 days) The Java programming language Level 2:  26 - 28.11.01 (3 days) Programmation TSX Premium 2 : 26 ...

  9. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Cadence Board Design tools : Upgrading to release 14 :  3 1-day sessions on 9, 10 & 11.10.01 MS-Project 2000 - niveau 1 : 15 - 18.10.01 (4 demi-journées) LabView Base 2 : 18 & 19.10.01 (2 jours) WORD 2000 : importer et manipuler des images : 19.10.01 (1 journée) Contract Follow-up (F) :  30.10.01 (1/2 journée) The CERN Engineering Data Management System for Electronics Design :  30.10.01 (1 day) UNIX pour non-programmeurs : 5 - 7.11.01 (3 jours) The Java programming language Level 1: 8 - 9.11.01 (2 days) LabView Base 1 : 12 - 14.11.01 (3 jours) Introduction to PERL 5 :  15 - 16.11.01  (2 days) Introduction to XML :  19 - 20.11.01 (2 days) Programming TSX Premium 1 :  19 - 23.11.01  (5 days) Introduction to C Programming :  21- 23.11.01 (3 days) The Java programming language Level 2:  26 - 28.11.01 (...

  10. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Introduction à Windows 2000 au CERN : 2 sessions de _ journée les 24 et 25.9.01 PROFIBUS : 25 - 26.9.01 (2 jours) PROFIBUS : 27 - 28.9.01 (2 days) EXCEL 2000 - niveau 1 : 3 et 4.10.01 (2 jours) Automates et réseaux de terrain : 3 - 4.10.2001 (2 jours) Introduction à Outlook : 5.10.01 (1 journée) Frontpage 2000 - niveau 1 : 8 et 9.10.01 (2 jours) C++ for Particle Physicists : 8 - 12.10.01 (6 lectures) MS-Project 2000 - niveau 1 : 15 - 18.10.01 (4 demi-journées) Programmation TSX Premium 1 : 15 - 19.10.01 (5 jours) WORD 2000 : importer et manipuler des images : 19.10.01 (1 journée) Programmation TSX Premium 1 : 22 - 26.10.01 (5 jours) UNIX pour non-programmeurs : 5 - 7.11.01 (3 jours) The Java programming language Level 1: 8 - 9.11.01 (2 days) Introduction to PERL 5 :  15 - 16.11.01  (2 days) Introduction to XML :  19 - 20.11.01 (2...

  11. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: LabView DAQ  (F) : 7 & 8.2.02 (2 jours) Hands-on Object-Oriented Design & Programming with Java :  11 - 13.02.02 (3 days) PVSS basics :  18 - 22.2.02 (5 days) Introduction à Windows 2000 : 18.2.02 (1 demi-journée) Introduction to the CERN Engineering Data Management System :  20.2.02 (1 day) Introduction à la CAO CADENCE : 20 & 21.2.02 (2 jours) The CERN Engineering Data Management System for Advanced users :  21.2.02  (1 day) LabView Basics 1 :  4 - 6.3.02  (3 days) Introduction au VHDL et utilisation du simulateur de CADENCE : 6 & 7.3.02 (2 jours) LabView Base 2 : 11 & 12.3.02 (2 jours) C++ for Particle Physicists :  11 - 15.3.2002  (6 * 3 hour lectures) LabView Advanced :  13 - 15.3.02 (3 days) Cours sur la migration AutoCAD :   AutoCAD : Mise à...

  12. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses: The CERN EDMS for Local Administrators (free of charge) : 24 & 25.9.03 (2 days) HeREF-2003 : Techniques de la réfrigération Hélium (cours en français avec support en anglais) : 6 - 10.10.2003 (7 demi-journées) The Java Programming Language Level 1 : 6 - 7.10.2003 (2 days) Java 2 Enterprise Edition - Part 2 : Enterprise JavaBeans : 8 - 10.10.2003 (3 days) FileMaker - niveau 1 : 9 & 10.10.03 (2 jours) EXCEL 2000 - niveau 1 : 20 & 22.10.03 (2 jours) AutoCAD 2002 - niveau 1 : 20, 21, 27, 28.10.03 (4 jours) CLEAN-2002 : Working in a Cleanroom (free of charge) : 23.10.03 (half day) AutoCAD Mechanical 6 PowerPack (E) : 23, 24, 30, 31.10 & 12, 13.11.03 (6 days) AutoCAD 2002 - niveau 2 : 10 & 11.11.03 (2 jours) ACCESS 2000 - niveau 1 : 13 & 14.11.03 (2 jours) FrontPage 2000 - niveau 1 : 20...

  13. Places available **

    CERN Multimedia

    2003-01-01

    Places are available in the following courses: PIPES-2003 - Pratique du Sertissage de tubes métalliques et multicouches : 26.8.03 (stage pratique) The CERN Engineering Data Management System (EDMS) for Engineers : 27.8.03 (1 day, free of charge) CLEAN-2002 : Travailler en salle blanche : 4.9.03 (une demi-journée, séminaire gratuit) The CERN Engineering Data Management System (EDMS) for Local Administrators : 24 & 25.9.03 (2 days, free of charge) Siemens SIMATIC Training : Programmation STEP7 - niveau 1 : 29 - 2.10.03 (4 jours) - ouverture des inscriptions fin août Programmation STEP7 - niveau 2 : 13 - 17.10.03 (5 jours) - ouverture des inscriptions fin août Réseau Simatic Net : 22 & 23.10.03 (2 jours) - ouverture des inscriptions fin août CLEAN-2002 : Working in a Cleanroom : 23.20.03 (half day, free of charge) These courses will be given in French or Englis...

  14. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : The CERN EDMS for Local Administrators : 24 & 25.9.03 (2 days, free of charge) HeREF-2003 : Techniques de la réfrigération Hélium (cours en français avec support en anglais) : 6 - 10.10.2003 (7 demi-journées) The Java Programming Language Level 1 : 6 - 7.10.2003 (2 days) Java 2 Enterprise Edition - Part 2 : Enterprise JavaBeans : 8 - 10.10.2003 (3 days) FileMaker - niveau 1 : 9 & 10.10.03 (2 jours) EXCEL 2000 - niveau 1 : 20 & 22.10.03 (2 jours) AutoCAD 2002 - niveau 1 : 20, 21, 27, 28.10.03 (4 jours) CLEAN-2002 : Working in a Cleanroom : 23.10.03 (half day, free of charge) AutoCAD 2002 - Level 1 : 3, 4, 12, 13.11.03 (4 days) AutoCAD 2002 - niveau 2 : 10 & 11.11.03 (2 jours) ACCESS 2000 - niveau 1 : 13 & 14.11.03 (2 jours) AutoCAD Mechanical 6 PowerPack (E) : 17, 18, 24, 25.11 & 1, 2.12.03 (6...

  15. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses : EXCEL 2000 - niveau 1 : 10 & 11.6.03 (2 jours) Conception de PCB rapides dans le flot Cadence : 11.6.03 (matin) EXCEL 2000 - level 1 : 12 & 13.6.03 (2 days) Introduction to PVSS : 16.6.03 (p.m.) Basic PVSS : 17 - 19.6.03 (3 days) Réalisation de PCB rapides dans le flot Cadence : 17.6.03 (matin) PVSS - JCOP Framework Tutorial : 20.6.03 (1 day) EXCEL 2000 - niveau 2 : 24 & 25.6.03 (2 jours) Siemens SIMATIC Training : Introduction to STEP7 : 3 & 4.6.03 (2 jours/2 days) STEP7 Programming : 16 - 20.6.03 (5 jours/5 days) Simatic Net Network : 26 & 27.6.03 (2 jours/2 days) These courses will be given in French or English following the requests. Programmation automate Schneider : Programmation automate Schneider TSX Premium - 1er niveau : 10 - 13.6.03 (4 jours) - audience : toute personne qui veux maitriser la msie en uvre et la programmation d'un automate TSX Premium - objectifs : maitriser la mise en uvre et la programmation d'un autom...

  16. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses: CLEAN-2002 : Travailler en salle blanche (séminaire gratuit) : 4.9.03 (une demi-journée) The CERN EDMS for Local Administrators (free of charge) : 24 & 25.9.03 (2 days) HeREF-2003 : Techniques de la réfrigération Hélium (cours en français avec support en anglais) : 6 - 10.10.2003 (7 demi-journées) The Java Programming Language Level 1 : 6 - 7.10.2003 (2 days) Java 2 Enterprise Edition - Part 2 : Enterprise JavaBeans : 8 - 10.10.2003 (3 days) FileMaker - niveau 1 : 9 & 10.10.03 (2 jours) EXCEL 2000 - niveau 1 : 20 & 22.10.03 (2 jours) AutoCAD 2002 - niveau 1 : 20, 21, 27, 28.10.03 (4 jours) CLEAN-2002 : Working in a Cleanroom (free of charge) : 23.10.03 (half day) AutoCAD Mechanical 6 PowerPack (E) : 23, 24, 30, 31.10 & 12, 13.11.03 (6 days) AutoCAD 2002 - niveau 2 : 10 & 11.11.03 (2 jours)...

  17. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: November 2002   Introduction to PVSS (free of charge): 11.11.02  (afternoon) EXCEL 2000 - niveau 1 :  12 & 13.11.02  (2 jours) CLEAN-2002: Working in a Cleanroom (English, free of charge):  13.11.2002  (afternoon) AutoCAD 2002 - niveau 1 :  14, 15, 21, 22.11.02  (4 jours) Hands-on Object-Oriented Design and Programming with C++:  19 - 21.11.02  (3 days)  EXCEL 2000 - niveau 2 :  25 & 26.11.02  (2 jours) FrontPage 2000 - niveau 1 :  27 & 28.11.02  (2 jours) December 2002   LabVIEW - DSC (English) :  2 - 3.12.02  (2 days) AutoCAD 2002 - niveau 2 :  2 & 3.12.02  (2 jours) FileMaker (Français) :  2 - 5.12.02  (4 jours) PCAD Schémas - Débutants :  5 & 6.12.02 ...

  18. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Introduction à Windows 2000 au CERN : 2 sessions de _ journée les 24 et 25.9.01 PROFIBUS : 25 - 26.9.01 (2 jours) PROFIBUS : 27 - 28.9.01 (2 days) PowerPoint 2000 : 1 et 2.10.01 (2 jours) EXCEL 2000 - niveau 1 : 3 et 4.10.01 (2 jours) Automates et réseaux de terrain : 3 - 4.10.2001 (2 jours) PCAD Schémas - débutants : 4 - 5.10.01 (2 jours) Introduction à Outlook : 5.10.01 (1 journée) Frontpage 2000 - niveau 1 : 8 et 9.10.01 (2 jours) PCAD PCB - débutants : 8 - 10.10.01 (3 jours) C++ for Particle Physicists : 8 - 12.10.01 (6 3-hour lectures) MS-Project 2000 - niveau 1 : 15 - 18.10.01 (4 demi-journées) LabView Basics 1 :  15 - 17.10.01  (3 days) Programmation TSX Premium 1 : 15 - 19.10.01 (5 jours) WORD 2000 : importer et manipuler des images : 19.10.01 (1 journée) Programmation TSX Premium 1 : 22 - 26.10.01...

  19. PLACES AVAILABLE

    CERN Multimedia

    Technical training; Tel. 74924

    2001-01-01

    Places are available in the following courses: PVSS Basics : 20 - 24.8.01 (5 days) PROFIBUS : 25 - 26.9.01 (2 jours) PROFIBUS : 27 - 28.9.01 (2 days) PCAD Schémas - débutants : 4 - 5.10.01 (2 jours) PCAD PCB - débutants : 8 - 10.10.01 (3 jours) Programming TSX Premium 1: 15 - 19.10.01 (5 days) Programmation TSX Premium 1 : 22 - 26.10.01 (5 jours) Programming TSX Premium 2: 19 - 23.11.01 (5 days) Programmation TSX Premium 2 : 26 - 30.11.01 (5 jours) The following LabView courses will be given in either English or French according to demand LabVIEW - Base 1 / LabVIEW - Basics 1 : 10 - 12.9.01 (3 jours / 3 days) LabVIEW - DAQ / LabVIEW - DAQ : 13 - 14.9.01 (2 jours / 2 days) LabVIEW - Base 1 / LabVIEW - Basics 1 : 15 - 17.10.01 (3 jours / 3 days) LabVIEW - Base 2 / LabVIEW - Basics 2 : 18 - 19.10.01 (2 jours / 2 days) LabVIEW - Base 1 / LabVIEW - Basics 1 : 12 - 14.11.01 (3 jours / 3 days) LabVIEW - DAQ / LabVIEW - DAQ : 15 - 16.11.01 (2 jours / 2...

  20. PLACES AVAILABLE

    CERN Multimedia

    Technical training; Tel. 74924

    2001-01-01

    Places are available in the following courses: PROFIBUS : 25 - 26.9.01 (2 jours) PROFIBUS : 27 - 28.9.01 (2 days) Automates et réseaux de terrain : 3 - 4.10.2001 (2 jours) PCAD Schémas - débutants : 4 - 5.10.01 (2 jours) PCAD PCB - débutants : 8 - 10.10.01 (3 jours) Programmation TSX Premium 1 : 15 - 19.10.01 (5 jours) Programmation TSX Premium 1 : 22 - 26.10.01 (5 jours) Programming TSX Premium 2: 19 - 23.11.01 (5 days) Programmation TSX Premium 2 : 26 - 30.11.01 (5 jours) Autocad Migration support courses: a detailed calendar will be published shortly for this series of sessions which will start on 15.10.2001. Registration is already open AutoCAD : Mise à jour AutoCAD r-14 vers 2002 (2 jours) AutoCAD Mechanical PowerPack 6 basé sur AutoCAD 2002 (5 jours) The following LabView courses will be given in either English or French according to demand LabVIEW - Base 1 / LabVIEW - Basics 1 : 10 - 12.9.01 (3 jours / 3 days)...

  1. PLACES AVAILABLES

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: PVSS Basics : 20 - 24.8.01 (5 days) PROFIBUS : 25 - 26.9.01 (2 jours) PROFIBUS : 27 - 28.9.01 (2 days) PCAD Schémas - débutants : 4 - 5.10.01 (2 jours) PCAD PCB - débutants : 8 - 10.10.01 (3 jours) Programming TSX Premium 1: 15 - 19.10.01 (5 days) Programmation TSX Premium 1 : 22 - 26.10.01 (5 jours) Programming TSX Premium 2: 19 - 23.11.01 (5 days) Programmation TSX Premium 2 : 26 - 30.11.01 (5 jours) The following LabView courses will be given in either English or French according to demand LabVIEW - Base 1 / LabVIEW - Basics 1 : 10 - 12.9.01 (3 jours / 3 days) LabVIEW - DAQ / LabVIEW - DAQ : 13 - 14.9.01 (2 jours / 2 days) LabVIEW - Base 1 / LabVIEW - Basics 1 : 15 - 17.10.01 (3 jours / 3 days) LabVIEW - Base 2 / LabVIEW - Basics 2 : 18 - 19.10.01 (2 jours / 2 days) LabVIEW - Base 1 / LabVIEW - Basics 1 : 12 - 14.11.01 (3 jours / 3 days) LabVIEW - DAQ / LabVIEW - DAQ : 15 - 16.11.01 (2 jours / 2...

  2. PLACES AVAILABLE

    CERN Document Server

    Enseignement Technique; Tél. 74924; Technical Training; Monique Duval; Tel. 74924

    2000-01-01

    Places are available in the following courses : Premiers pas avec votre PC 12 - 15.9.00 (4 demi-journées) WORD 20, 21 et 26, 27.9.2000 (4 jours) JAVA programming level 1 25 - 26.9.2000 (2 days) Gaz inflammables 1 26.9.2000 (1 journée) Advanced aspects of PERL 5 6.10.2000 (1 day) Initiation au WWW 10 - 12.10.00 (3 demi-journées) WORD : importer et manipuler des images 16.10.2000 (1 journée) FileMaker 17, 18 et 24, 25.10.00 (4 jours) Nouveautés de WORD 19 et 20.10.2000 (2 jours) ACCESS 1er niveau 30 - 31.10.00 (2 jours)Introduction à PowerPoint 6.11.00 (1 journée)Nouveautés d’EXCEL 7.11.2000(4 demi-journées)Excel 13, 14 et 20, 21.11.00 (4 jours) LabView hands-on 13.11.2000(4 hours)LabView Basics 1 14 - 16.11.2000 (3 days) MS-Project 1er niveau 14-17.11.00 (4 demi-journées) If you wish to participate in one of these courses, please discuss with your supervisor and apply elec...

  3. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: LabView hands-on (bilingue/bilingual): 5.11.02 (matin/morning) LabView DAQ hands-on (bilingue/bilingual):  5.11.02  (après-midi afternoon) Introduction au PC et Windows 2000 au CERN:  6 & 7.11.02  (2 jours) Oracle 8i : Access the Database with Java:  7 & 8.11.02  (2 days) AutoCAD 2002 - niveau 2:  7 & 8.11.02  (2 jours) Introduction to PVSS (free of charge):  11.11.2002 pm  (1/2 day) Basic PVSS:  12 - 14.11.02  (3 days) EXCEL 2000 - niveau 1:  12 & 13.11.02  (2 jours) CLEAN-2002: Working in a Cleanroom (English, free of charge):  13.11.2002  (afternoon) LabView Base 1 :  13 - 15.11.02  (3 jours) AutoCAD 2002 - Level 1:  14, 15, 21, 22.11.2002  (4 days) LabVIEW - Advanced:  18 - 20.11.02  (3 days) Auto...

  4. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: LabView Base 1 :  23 - 25.9.02  (3 jours) Object-Oriented Analysis & Design using UML:  25 - 27.9.02  (3 days) LabView DAQ (E):  26 - 27.9.02  (2 days) Introduction to Oracle 8i : SQL and PL/SQL:  7 - 11.10.02  (5 days) CLEAN-2002 : Working in a Cleanroom (free of charge):  10.10.02  (half-day, p.m.) AutoCAD 2002 - niveau 2 :  14 - 15.10.02  (2 jours) Introduction à DesignSpace :  16.10.02  (1 journée) Introduction to DesignSpace:  17.10.02  (1 day) AutoCAD 2002 - Level 1:  17, 18, 24, 25.10.02  (4 days) AutoCAD Mechanical 6 PowerPack (F) :  21, 22, 23.10 et 4, 5, 6.11.02  (6 jours) Introduction à ANSYS/Introduction to ANSYS (langue à définir suivant demande/ Language to be chosen according to demand):...

  5. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: November 2002   LabView hands-on (bilingue/bilingual): 5.11.02 (matin/morning) LabView DAQ hands-on (bilingue/bilingual):  5.11.02  (après-midi afternoon) PCAD Schémas - Débutants :  5 & 6.11.02  (2 jours) PCAD PCB - Débutants :  9 - 11.11.02  (3 jours) Introduction au PC et Windows 2000 au CERN :  6 & 7.11.02  (2 jours) Oracle 8i : Access the Database with Java :  7 & 8.11.02  (2 days) Introduction to PVSS (free of charge):  11.11.2002 pm  (1/2 day) Basic PVSS:  12 - 14.11.02  (3 days) EXCEL 2000 - niveau 1 :  12 & 13.11.02  (2 jours) CLEAN-2002: Working in a Cleanroom (English, free of charge):  13.11.2002  (afternoon) LabView Base 1 :  13 - 15.11.02  (3 jours) AutoCAD 2002 - niveau 1 :  14, 15, 21, 22.11.02  (4 jours) LabVIEW - Advanced:  18 - 20.11.02  (3 days) Hands-on Object-Oriented Design and Programming with C++ :  19 - 21.11.02  (3 days)  LabVIEW - Basics 2:  21 - 22.11.02 ...

  6. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: Java 2 Enterprise Edition - Part 2: Enterprise JavaBeans:  18 - 20.9.02  (3 days) AutoCAD 2002 - niveau 1 :  19, 20, 26, 27.9.02  (4 jours) LabView Base 1 :  23 - 25.9.02  (3 jours) Object-Oriented Analysis & Design using UML:  25 - 27.9.02  (3 days) LabView DAQ (E):  26 - 27.9.02  (2 days) Introduction to Oracle 8i : SQL and PL/SQL:  7 - 11.10.02  (5 days) CLEAN-2002 : Working in a Cleanroom (free of charge):  10.10.02  (half-day, p.m.) AutoCAD 2002 - niveau 2 :  14 - 15.10.02  (2 jours) Introduction à DesignSpace :  16.10.02  (1 journée) Introduction to DesignSpace:  17.10.02  (1 day) AutoCAD 2002 - Level 1:  17, 18, 24, 25.10.02  (4 days) AutoCAD Mechanical 6 PowerPack (F) :  21, 22, 23.10 et 4, 5, 6.11....

  7. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: Introduction à DesignSpace :  16.10.02  (1 journée) AutoCAD Mechanical 6 PowerPack (F) :  21, 22, 23.10 et 4, 5, 6.11.02  (6 jours) Introduction à ANSYS 21 - 25.10.02  (5 jours/days) HREF-2002: Helium Refrigeration Techniques (English-French, bilingual) :  21 - 25.10.2002  (7 half days) LabVIEW Basics 1 (English):  21 - 23.10.02  (3 days) LabVIEW Basics 2 (English):  24 & 25.10.02  (2 days) Oracle 8i : Access the Database with Java:  7 & 8.11.02  (2 days) AutoCAD 2002 - niveau 2 :  7 & 8.11.02  (2 jours) AutoCAD 2002 - Level 1:  14, 15, 21, 22.11.02  (4 days) LabVIEW - Advanced (English) :  18 - 20.11.2002  (3 days) AutoCAD 2002 - niveau 1 :  19, 20, 25, 26.11.02 (4 jours) Oracle iDS Designer: First Class:&...

  8. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: Introduction to Oracle 8i : SQL and PL/SQL:  7 - 11.10.02  (5 days) CLEAN-2002 : Working in a Cleanroom (free of charge):  10.10.02  (half-day, p.m.) AutoCAD 2002 - niveau 2 :  14 - 15.10.02  (2 jours) Introduction à DesignSpace :  16.10.02  (1 journée) Introduction to DesignSpace:  17.10.02  (1 day) AutoCAD 2002 - Level 1:  17, 18, 24, 25.10.02  (4 days) AutoCAD Mechanical 6 PowerPack (F) :  21, 22, 23.10 et 4, 5, 6.11.02  (6 jours) Introduction à ANSYS/Introduction to ANSYS (langue à définir suivant demande/ Language to be chosen according to demand):  21 - 25.10.02  (5 jours/days) HREF-2002: Helium Refrigeration Techniques (English-French, bilingual) :  21 - 25.10.2002  (7 half days) HREF-2002: Techniques de la Réfri...

  9. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses: PIPES-2003 - Pratique du sertissage de tubes métalliques et multicouches :26.8.03(stage pratique) The CERN EDMS for Engineers (free of charge) : 27.8.03 (1 day) CLEAN-2002 : Travailler en salle blanche (séminaire gratuit) : 4.9.03(une demi-journée) The CERN EDMS for Local Administrators (free of charge) : 24 & 25.9.03 (2 days) HeREF-2003 : Techniques de la réfrigération Hélium (cours en français avec support en anglais) : 6 - 10.10.2003 (7 demi-journées) The Java Programming Language Level 1 : 6 - 7.10.2003 (2 days) Java 2 Enterprise Edition - Part 2 : Enterprise JavaBeans : 8 - 10.10.2003 (3 days) FileMaker - niveau 1 : 9 & 10.10.03 (2 jours) EXCEL 2000 - niveau 1 : 20 & 22.10.03 (2 jours) AutoCAD 2002 - niveau 1 : 20, 21, 27, 28.10.03 (4 jours) CLEAN-2002 : Working in a Cleanroom (free of charge) : 23.10.03 (half day) AutoCAD Mechanical 6 PowerPack (E) : 23, 24, 30, 31.10 & 12, 13.11.03 (6 days) AutoCAD 2002 - niveau 2...

  10. PLACES AVAILABLE

    CERN Multimedia

    Monique Duval

    2002-01-01

    Places are available in the following courses: Introduction to Oracle 8i : SQL and PL/SQL:  7 - 11.10.02  (5 days) CLEAN-2002 : Working in a Cleanroom (free of charge):  10.10.02  (half-day, p.m.) LabView Hands-on (bilingue/bilingual) : 10.10.02 (matin/morning) LabView DAQ Hands-on (bilingue/bilingual)  10.10.02 (après-midi /afternoon) Introduction à DesignSpace :  16.10.02  (1 journée) Introduction to DesignSpace:  17.10.02  (1 day) AutoCAD Mechanical 6 PowerPack (F) :  21, 22, 23.10 et 4, 5, 6.11.02  (6 jours) Introduction à ANSYS/Introduction to ANSYS (langue à définir suivant demande/ Language to be chosen according to demand):  21 - 25.10.02  (5 jours/days) HREF-2002: Helium Refrigeration Techniques (English-French, bilingual) :  21 - 25.10.2002  (7 half days) HREF-2002: Techniques de la...

  11. Places available**

    CERN Multimedia

    2003-01-01

    Places are available in the following courses: The CERN EDMS for Local Administrators : 24 & 25.9.03 (2 days, free of charge) HeREF-2003 : Techniques de la réfrigération Hélium cours en français avec support en anglais) : 6 - 10.10.2003 (7 demi-journées) The Java Programming Language Level 1 : 6 - 7.10.2003 (2 days) Java 2 Enterprise Edition - Part 2 : Enterprise JavaBeans : 8 - 10.10.2003 (3 days) FileMaker - niveau 1 : 9 & 10.10.03 (2 jours) EXCEL 2000 - niveau 1 : 20 & 22.10.03 (2 jours) AutoCAD 2002 - niveau 1 : 20, 21, 27, 28.10.03 (4 jours) CLEAN-2002 : Working in a Cleanroom : 23.10.03 (half day, free of charge) AutoCAD 2002 - Level 1 : 3, 4, 12, 13.11.03 (4 days) AutoCAD 2002 - niveau 2 : 10 & 11.11.03 (2 jours) ACCESS 2000 - niveau 1 : 13 & 14.11.03 (2 jours) AutoCAD Mechanical 6 PowerPack (E) : 17, 18, 24, 25.11 & 1, 2.12.03 (6 days) FrontPage 2000 - niveau 1 : 20 & 21.11.03 (2 jours) MAGNE-03 : Magnétisme pour l'électrotechnique : 25 - 27.11.03 (3 jours) ...

  12. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Nouveautés d'EXCEL : 5.11.01 (1/2 journée) Introduction a Windows 2000 au CERN : 6.11.01 (1/2 journée) UNIX pour non-programmeurs : 5 - 7.11.01 (3 jours) Design Patterns :  7 - 8.11.01 (2 days) The Java programming language Level 1: 8 - 9.11.01 (2 days) Automates et réseaux de terrain : 13 & 14.11.01 (3 jours) Introduction à Windows 2000 au CERN : 12 - 14.11.01 (1/2 journée) Introduction to Windows 2000 at CERN :  14.11.01  (half-day) Introduction to PERL 5 :  15 - 16.11.01  (2 days) Introduction to C Programming :  21- 23.11.01 (3 days) Programmation TSX Premium 2 : 26 - 30.11.01 (5 jours) Contract Follow-up (F) : 26.11.01 (1/2 journée) Object-Oriented Analysis and Design :  27 - 30.11.2001  (4 days) Hands-on Object-Oriented Design and Programming with C++ :  11 - 13.12.2...

  13. [Not Available].

    Science.gov (United States)

    Usleber, E; Dietrich, R; Schneider, E; Märtlbauer, E

    2001-06-01

    satratoxin H per cm(2). As far as we know, this is the first documented case of indoor Stachybotrys toxins in Germany. The toxin concentration by far exceeds the minimum toxin level required for skin toxicity, and was considered as unhealthy. Health authorities in Munich were informed but were unable to provide assistance, probably because awareness of the importance and the possible health risks caused by indoor mycotoxins is not yet widespread in Germany. Reporting and monitoring programs for mycotoxins in water-damaged buildings seem to be necessary to provide insight into the occurrence of similar cases as the one described here.

  14. Request for Naval Reactors Comment on Proposed Prometheus Space Flight Nuclear Reactor High Tier Reactor Safety Requirements and for Naval Reactors Approval to Transmit These Requirements to JPL

    Energy Technology Data Exchange (ETDEWEB)

    D. Kokkinos

    2005-04-28

    The purpose of this letter is to request Naval Reactors comments on the nuclear reactor high tier requirements for the PROMETHEUS space flight reactor design, pre-launch operations, launch, ascent, operation, and disposal, and to request Naval Reactors approval to transmit these requirements to Jet Propulsion Laboratory to ensure consistency between the reactor safety requirements and the spacecraft safety requirements. The proposed PROMETHEUS nuclear reactor high tier safety requirements are consistent with the long standing safety culture of the Naval Reactors Program and its commitment to protecting the health and safety of the public and the environment. In addition, the philosophy on which these requirements are based is consistent with the Nuclear Safety Policy Working Group recommendations on space nuclear propulsion safety (Reference 1), DOE Nuclear Safety Criteria and Specifications for Space Nuclear Reactors (Reference 2), the Nuclear Space Power Safety and Facility Guidelines Study of the Applied Physics Laboratory.

  15. High School Seniors' Career Interests, Educational Plans, and Perceptions of Programs and Services Available at Walla Walla Community College.

    Science.gov (United States)

    VanAusdle, Steven L.; And Others

    In order to develop a marketing program for potential students and assist in institutional planning, a study was conducted at Walla Walla Community College (WWCC), Washington, to obtain information from high school seniors regarding their career interests, educational plans, and perceptions of WWCC's programs and services. Questionnaires were…

  16. [Not Available].

    Science.gov (United States)

    Gutiérrez Avendaño, Jairo

    2016-01-01

    To analyse sociodemographic characteristics, descriptive psychopathology and therapy in the first decade of service of the Hospital Psiquiátrico San Isidro del Valle del Cauca, 1958-1968. Retrospective descriptive study of a series of case histories of the studied period, and by qualitative analysis and conceptual networks. Sociodemographic variables were analysed, and it was observed that, although the patient population increased, hospitalisation was reduced due to the implementation of a "Day Hospital" and outpatient services. The majority of patients were young adults, women engaged in housework, and several lower-middle income patients, primarily referred by their families. Hospital stay was short, with a high frequency of readmissions. The main reason for discharge was improvement, and the predominant diagnosis and symptomatology was schizophrenia, with the treatment being antipsychotic neuroleptics. The correlation of the short time of hospitalisation, more outpatient clinics, the large number of readmissions, and improvement as the reason for discharge, is consistent with the results of the International Pilot Study of Schizophrenia 1968, which included a sample of 100 patients from Hospital psychiatric San Isidro del Valle del Cauca, in which it was concluded that the disorder did not cause a progressive deterioration in patients and that, on the contrary, showed a significant percentage recovery. Copyright © 2015 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  17. [Not Available].

    Science.gov (United States)

    Palep, Jaydeep H

    2009-01-01

    The term "robot" was coined by the Czech playright Karel Capek in 1921 in his play Rossom's Universal Robots. The word "robot" is from the check word robota which means forced labor. The era of robots in surgery commenced in 1994 when the first AESOP (voice controlled camera holder) prototype robot was used clinically in 1993 and then marketed as the first surgical robot ever in 1994 by the US FDA. Since then many robot prototypes like the Endoassist (Armstrong Healthcare Ltd., High Wycombe, Buck, UK), FIPS endoarm (Karlsruhe Research Center, Karlsruhe, Germany) have been developed to add to the functions of the robot and try and increase its utility. Integrated Surgical Systems (now Intuitive Surgery, Inc.) redesigned the SRI Green Telepresence Surgery system and created the daVinci Surgical System((R)) classified as a master-slave surgical system. It uses true 3-D visualization and EndoWrist((R)). It was approved by FDA in July 2000 for general laparoscopic surgery, in November 2002 for mitral valve repair surgery. The da Vinci robot is currently being used in various fields such as urology, general surgery, gynecology, cardio-thoracic, pediatric and ENT surgery. It provides several advantages to conventional laparoscopy such as 3D vision, motion scaling, intuitive movements, visual immersion and tremor filtration. The advent of robotics has increased the use of minimally invasive surgery among laparoscopically naïve surgeons and expanded the repertoire of experienced surgeons to include more advanced and complex reconstructions.

  18. High-end climate change impact on European water availability and stress: exploring the presence of biases

    Directory of Open Access Journals (Sweden)

    L. V. Papadimitriou

    2015-07-01

    Full Text Available Climate models project a much more substantial warming than the 2 °C target making higher end scenarios increasingly plausible. Freshwater availability under such conditions is a key issue of concern. In this study, an ensemble of Euro-CORDEX projections under RCP8.5 is used to assess the mean and low hydrological states under +4 °C of global warming for the European region. Five major European catchments were analyzed in terms of future drought climatology and the impact of +2 vs. +4 °C global warming was investigated. The effect of bias correction of the climate model outputs and the observations used for this adjustment was also quantified. Projections indicate an intensification of the water cycle at higher levels of warming. Even for areas where the average state may not considerably be affected, low flows are expected to reduce leading to changes in the number of dry days and thus drought climatology. The identified increasing or decreasing runoff trends are substantially intensified when moving from the +2 to the +4 °C of global warming. Bias correction resulted in an improved representation of the historical hydrology. It is also found that the selection of the observational dataset for the application of the bias correction has an impact on the projected signal that could be of the same order of magnitude to the selection of the RCM.

  19. [Not Available].

    Science.gov (United States)

    Abril, Encarnación; Gómez-Conesa, Antonia; Gutiérrez-Santos, Manuel

    2008-05-01

    To assess the quality of physiotherapeutic care in patients treated for low back pain in a Primary Health Care physiotherapy unit, and to improve the quality of the care provided to these patients. The first assessment includes all patients treated in 2002 (n=83). Five criteria corresponding to the initial physiotherapeutic assessment were chosen: C1, pain; C2, disability; C3, mobility, muscle examination, and C5, palpation. In order to detect non-compliance, the Ishikawa Fishbone diagram was used. Corrective measures were established in November 2003: publication of an Oswestry questionnaire model for assessing disability and reflecting on the results obtained. The second assessment includes the period of time from 1st November 2003 to 6th April 2004 (n=32). In the initial assessment, compliances observed were: C1: 21.69%; C2: 0; C3: 69.87%; C4: 78.31%, and C5: 84.33%. After implementing corrective measures a significant improvement was observed in the compliance of C1, C2, and C3. In C4 there was an improvement, and in C5 there was a decrease in compliance, both of them without statistical significance. The carrying out of an improvement cycle has enabled non-compliances in the application of this protocol to be detected and corrected. The corrective measures implemented have led to a reduction of the variability in the records. It is advisable to ensure that compliance does not decrease in the areas that initially showed a high level of compliance. Copyright © 2008 Sociedad Española de Calidad Asistencial. Published by Elsevier Espana. All rights reserved.

  20. [Not Available].

    Science.gov (United States)

    Höck, P

    1994-01-01

    The central region of Switzerland did not participate in the development of psychiatry in the 19th century. It was not before 1909 that the providing for insanes was taken in hand. At that time the capuchin Rufin Steimer founded the first catholic infirmary for mental diseases under the name "Franziskusheim" in the canton of Zug. Brethren of charity came to conduct it. Steimer realized there a project which formerly had seemed impossible. But he was no expert, and his hospital could not be perfect. It was merely a place for taking persons in custody. Because this sanatorium was restricted for men, one had no provision for women until 1927. In this year, the congregation of Sisters of the Holy Cross in Menzingen inaugurated a catholic women's infirmary in an aristocratic villa called "Meisenberg". Both hospitals came under the common direction of professor Johann Baptist Manser. Then they were extended, brought up to date and got modern institutions for treatment. His succesors maintained the high standard. The Franziskusheim as the greater of them is now the psychiatric centre of the cantons of Uri, Schwyz, and Zug. A new building has been opened in March 1994. Both homes are private institutions till now and have preserved their religious background. The gradual rehabilitation of convalescents, the employment of persons with physical or mental defects and the care for sufferings from alcoholism or drugs are great duties of the present time. The above-mentioned cantons have therefore founded places of care and a Service of Social Medicine. There exist now houses for transitory or permanent lodging, special factory-places and particular workshops. These installations, self-help-groups and especially the "Foundation Phoenix" for advice and protection are giving useful and meritorious assistance.

  1. Is Very High Thyroid Stimulating Hormone Level Required in Differentiated Thyroid Cancer for Ablation Success?

    Directory of Open Access Journals (Sweden)

    Zekiye Hasbek

    2016-06-01

    Full Text Available Objective: Remnant ablation with radioactive iodine (I-131 is a successful form of treatment that aims to destroy the remaining residual tissue and/or metastatic tissue after total thyroidectomy in differentiated thyroid cancer (DTC patients. High level of thyroid stimulating hormone (TSH (≥30 mIU/L is recommended for success of ablation treatment. In this retrospective study, our aim was to investigate whether the TSH levels at the time of ablation effect the success of radioactive iodine remnant ablation. Methods: Patients who were diagnosed with DTC, treated with bilateral total/near total thyroidectomy and who were referred for I-131 remnant ablation were included in this study. Patients with undetectable TSH-stimulated serum thyroglobulin (Tg level, normal physical examination, negative results on whole body scan with I-131, and no evidence of neck lymph node metastasis on ultrasound were defined as disease-free. The correlation between TSH level at the time of ablation and ablation success was assessed. Results: Two hundred sixty one consecutive patients were included in the present study. Mean TSH level was 19.47±6 mIU/L in the 34 patients with TSH <30 mIU/L, while mean TSH level was 73.65±27 mIU/L in the 227 patients with TSH ≥30 mIU/L during I-131 remnant ablation. Ablation was unsuccessful in only one patient with TSH <30 mIU/L who had lung metastasis. Ablation was unsuccessful in 5.1% of patients with TSH ≥30 mIU/L. The effect of TSH level was not significant on ablation success (p=0.472. Conclusion: In conclusion, we think that a high TSH serum level alone is not a factor for the success of ablation. Age, presence of metastasis, extent of residual thyroid mass should also be considered. Especially, in the presence of metastatic tissue, obtaining adequate increase in TSH level is not always possible. The success of ablation at lower levels of TSH elevations may be sufficient for patients, and long-term hypothyroidism may not

  2. Operational characterisation of requirements and early validation environment for high demanding space systems

    Science.gov (United States)

    Barro, E.; Delbufalo, A.; Rossi, F.

    1993-01-01

    The definition of some modern high demanding space systems requires a different approach to system definition and design from that adopted for traditional missions. System functionality is strongly coupled to the operational analysis, aimed at characterizing the dynamic interactions of the flight element with its surrounding environment and its ground control segment. Unambiguous functional, operational and performance requirements are to be defined for the system, thus improving also the successive development stages. This paper proposes a Petri Nets based methodology and two related prototype applications (to ARISTOTELES orbit control and to Hermes telemetry generation) for the operational analysis of space systems through the dynamic modeling of their functions and a related computer aided environment (ISIDE) able to make the dynamic model work, thus enabling an early validation of the system functional representation, and to provide a structured system requirements data base, which is the shared knowledge base interconnecting static and dynamic applications, fully traceable with the models and interfaceable with the external world.

  3. [Not Available].

    Science.gov (United States)

    Carlino, A

    1994-01-01

    Anatomical fugitive sheets are of great interest, as a typographical genre, not only for the history of printing and the history of medicine, but also, more generally, for the history of culture as a whole. They were published as folio woodcuts (more rarely engravings) in Germany, France, Italy, England and the Netherlands from the end of the XVth centkury to the mid XVIIIth century. These sheets contain a figure representing the human body (male and female) and a text describing in a concise and quite rough way the elements of the illustration. What is unusual about these sheets is that the trunk of the figures and some of the internal organs can be lifted up or peeled away, like some contemporary books for children. The figures and some internal parts are very often coloured. Judging from the number of editions (I have found 15 editions published between 1538 and 1540!), anatomical sheets met with a huge commercial success and a very wide circulation indeed. Students of the faculties of medicine and philosophy and barber-surgeons were the more obvious consumers. Students would use them as aids to memory to accompany non-illustrated medical books; barbers to grasp some basic notions of the human body, useful for the practice of phlebotomy. They could be purchased in bookshops, but they were more likely to have been sold in market places or around the University where many colporteurs displayed their cheap prints and booklets. I shall argue, however, that anatomical fugitive sheets have also been produced for and used by a non-professional public, literate but not highly educated, unable to read Latin and more used to learning from images rather than from the written word. A public that was eager to discover the inner secrets of the bodily self, the divine machine that we inhabit. From a scientific point of view anatomical fugitive sheets often reveal errors and differences compared to academic textual and iconographic material on the same subject. The discrepancy

  4. High Altitude Long Endurance UAV Analysis of Alternatives and Technology Requirements Development

    Science.gov (United States)

    Nickol, Craig L.; Guynn, Mark D.; Kohout, Lisa L.; Ozoroski, Thomas A.

    2007-01-01

    An Analysis of Alternatives and a Technology Requirements Study were conducted for two mission areas utilizing various types of High Altitude Long Endurance (HALE) Unmanned Aerial Vehicles (UAV). A hurricane science mission and a communications relay mission provided air vehicle requirements which were used to derive sixteen potential HALE UAV configurations, including heavier-than-air (HTA) and lighter-than-air (LTA) concepts with both consumable fuel and solar regenerative propulsion systems. A HTA diesel-fueled wing-body-tail configuration emerged as the preferred concept given near-term technology constraints. The cost effectiveness analysis showed that simply maximizing vehicle endurance can be a sub-optimum system solution. In addition, the HTA solar regenerative configuration was utilized to perform both a mission requirements study and a technology development study. Given near-term technology constraints, the solar regenerative powered vehicle was limited to operations during the long days and short nights at higher latitudes during the summer months. Technology improvements are required in energy storage system specific energy and solar cell efficiency, along with airframe drag and mass reductions to enable the solar regenerative vehicle to meet the full mission requirements.

  5. Culture-Independent Metagenomic Surveillance of Commercially Available Probiotics with High-Throughput Next-Generation Sequencing.

    Science.gov (United States)

    Patro, Jennifer N; Ramachandran, Padmini; Barnaba, Tammy; Mammel, Mark K; Lewis, Jada L; Elkins, Christopher A

    2016-01-01

    Millions of people consume dietary supplements either following a doctor's recommendation or at their own discretion to improve their overall health and well-being. This is a rapidly growing trend, with an associated and expanding manufacturing industry to meet the demand for new health-related products. In this study, we examined the contents and microbial viability of several popular probiotic products on the United States market. Culture-independent methods are proving ideal for fast and efficient analysis of foodborne pathogens and their associated microbial communities but may also be relevant for analyzing probiotics containing mixed microbial constituents. These products were subjected to next-generation whole-genome sequencing and analyzed by a custom in-house-developed k-mer counting method to validate manufacturer label information. In addition, the batch variability of respective products was examined to determine if any changes in their formulations and/or the manufacturing process occurred. Overall, the products we tested adhered to the ingredient claims and lot-to-lot differences were minimal. However, there were a few discrepancies in the naming of closely related Lactobacillus and Bifidobacterium species, whereas one product contained an apparent Enterococcus contaminant in two of its three lots. With the microbial contents of the products identified, we used traditional PCR and colony counting methods to comparatively assess our results and verify the viability of the microbes in these products with regard to the labeling claims. Of all the supplements examined, only one was found to be inaccurate in viability. Our use of next-generation sequencing as an analytical tool clearly demonstrated its utility for quickly analyzing commercially available products containing multiple microbes to ensure consumer safety. IMPORTANCE The rapidly growing supplement industry operates without a formal premarket approval process. Consumers rely on product labels to

  6. Low-dose insulin infusions in diabetic patients with high insulin requirements.

    Science.gov (United States)

    Dandona, P; Foster, M; Healey, F; Greenbury, E; Beckett, A G

    1978-08-01

    Six patients with high insulin requirements (range 120-3000 units daily) have been infused with much smaller doses (range 50-63 units daily) of insulin intravenously. All six maintained adequate glucose homoestasis on this regimen. It is suggested that subcutaneous tissue at the site of injection may alter insulin or impair its absorption. Insulin resistance in some patients may be due to these mechanisms.

  7. Detection of highly toxic elements (lead and chromium) in commercially available eyeliner (kohl) using laser induced break down spectroscopy

    Science.gov (United States)

    Gondal, M. A.; Dastageer, M. A.; Al-Adel, F. F.; Naqvi, A. A.; Habibullah, Y. B.

    2015-12-01

    A sensitive laser induced breakdown spectroscopic system was developed and optimized for using it as a sensor for the detection of trace levels of lead and chromium present in the cosmetic eyeliner (kohl) of different price ranges (brands) available in the local market. Kohl is widely used in developing countries for babies as well adults for beautification as well eyes protection. The atomic transition lines at 405.7 nm and 425.4 nm were used as the marker lines for the detection of lead and chromium respectively. The detection system was optimized by finding the appropriate gate delay between the laser excitation and the data acquisition system and also by achieving optically thin plasma near the target by establishing the local thermodynamic equilibrium condition. The detection system was calibrated for these two hazardous elements and the kohl samples under investigation showed 8-15 ppm by mass of lead and 4-9 ppm by mass of Chromium, which are higher than the safe permissible levels of these elements. The limits of detection of the LIBS system for lead and chromium were found to be 1 and 2 ppm respectively.

  8. Variation in bird's originating nitrogen availability limits High Arctic tundra development over last 2000 year (Hornsund, Svalbard)

    Science.gov (United States)

    Skrzypek, Grzegorz; Wojtuń, Bronisław; Hua, Quan; Richter, Dorota; Jakubas, Dariusz; Wojczulanis-Jakubas, Katarzyna; Samecka-Cymerman, Aleksandra

    2016-04-01

    Arctic and subarctic regions play important roles in the global carbon balance. However, nitrogen (N) deficiency is a major constraint for organic carbon sequestration in the High Arctic. Hence, the identification of the relative contributions from different N-sources is critical for understanding the constraints that limit tundra growth. The stable nitrogen composition of the three main N-sources and numerous plants were analyzed in ten tundra types (including those influenced by seabirds) in the Fuglebekken catchment (Hornsund, Svalbard, 77°N 15°E). The percentage of the total tundra N-pool provided by seabirds' feces (from planktivorous colonially breeding little auks Alle alle), ranged from 0-21% in Patterned-ground tundra to 100% in Ornithocoprophilous tundra. The total N-pool utilized by tundra plants in the studied catchment originated from birds (36%), atmospheric deposition (38%), and N2-fixation (26%). The results clearly show that N-pool in the tundra is significantly supplemented by nesting seabirds. Thus, if they experienced climate change induced substantial negative environmental pressure, it would adversely influence the tundra N-budget (Skrzypek et al. 2015). The growth rates and the sediment thickness (PLoS ONE 10(9): e0136536.

  9. Pathophysiologic responses of sheep to brief high level nitrogen dioxide exposure. (Reannouncement with new availability information). Final report

    Energy Technology Data Exchange (ETDEWEB)

    Januszkiewicz, A.J.; Snapper, J.R.; Sturgis, J.W.; Rayburn, D.B.; Dodd, K.T.

    1992-12-31

    The cardiopulmonary response to short-duration, high- concentration nitrogen dioxide (N02) was examined in conscious domestic sheep (Ovis aries). Six intubated animals in each of three groups were administered or approximately 100 or 500 ppm NO2. Pulmonary and systemic hemodynamics, pulmonary mechanics, blood gases and hematologic variables were measured immediately before and after exposure and at 1, 4 and 24 h after exposure. Minute ventilation was monitored during exposure, and a pulmonary histopathologic examination was performed 24 h postexposure. Negligible effects were observed in the control group. Exposure to 100 ppm NO2 caused a modest increase in minute ventilation during exposure, and an increased number of leukocytes were found within interalveolar capillaries upon histologic examination. Exposure to 500 ppm NO2 induced immediate and profound lung irritant responses characterized by increases in lung resistance, respiratory rate and minute ventilation. The exposure was marked by a statistically significant, but small, mixed-venous methemoglobin increase. Pulmonary function progressively deteriorated in the 24-h period following exposure to 500 ppm NO2, and a significant arterial oxygen tension reducting and pulmonary artery pressure increase occurred at 24 h post exposure. Histologic examination after 500 ppm NO2 revealed patchy lobular exudation and accumulation of leukocytes in alveolar sacs and interalveolar capillaries.

  10. An Analysis of Testing Requirements for Fluoride Salt Cooled High Temperature Reactor Components

    Energy Technology Data Exchange (ETDEWEB)

    Holcomb, David Eugene [ORNL; Cetiner, Sacit M [ORNL; Flanagan, George F [ORNL; Peretz, Fred J [ORNL; Yoder Jr, Graydon L [ORNL

    2009-11-01

    This report provides guidance on the component testing necessary during the next phase of fluoride salt-cooled high temperature reactor (FHR) development. In particular, the report identifies and describes the reactor component performance and reliability requirements, provides an overview of what information is necessary to provide assurance that components will adequately achieve the requirements, and then provides guidance on how the required performance information can efficiently be obtained. The report includes a system description of a representative test scale FHR reactor. The reactor parameters presented in this report should only be considered as placeholder values until an FHR test scale reactor design is completed. The report focus is bounded at the interface between and the reactor primary coolant salt and the fuel and the gas supply and return to the Brayton cycle power conversion system. The analysis is limited to component level testing and does not address system level testing issues. Further, the report is oriented as a bottom-up testing requirements analysis as opposed to a having a top-down facility description focus.

  11. Clinical approach to the patient with diabetes mellitus and very high insulin requirements.

    Science.gov (United States)

    Ovalle, F

    2010-12-01

    A number of patients with diabetes require very high (> 2 Ukg⁻¹ day⁻¹), or extremely high (> 3 Ukg⁻¹ day⁻¹), insulin doses for the management of their hyperglycemia. Unfortunately, many of the physicians who treat these patients limit themselves to prescribing ever higher doses of insulin, without questioning why. Furthermore, when the insulin requirements get to be extreme, demanding an explanation, clinicians are frequently lost in a sea of literature where there is not a single paper dealing with this problem systematically. A systematic approach to the evaluation of these patients is necessary to facilitate an appropriate diagnosis, select the most reasonable therapy, and hopefully improve the long-term outcome of these patients. This manuscript intends to provide the clinician with a review of the literature pertinent for the differential diagnosis, work-up, and management of these patients. We will review the definitions of insulin sensitivity during normality, the various degrees or categories of insulin resistance, and the expected insulin requirements during each of these states. Subsequently, we propose a simple alphabetic mnemonic approach to help remember the differential diagnosis, and a clinical algorithm to help guide the work-up of these patients. Lastly, we briefly discuss general management considerations in these conditions.

  12. High-Level Functional and Operational Requirements for the Advanced Fuel Cycle Facilty

    Energy Technology Data Exchange (ETDEWEB)

    Charles Park

    2006-12-01

    High-Level Functional & Operational Requirements for the AFCF -This document describes the principal functional and operational requirements for the proposed Advanced Fuel Cycle Facility (AFCF). The AFCF is intended to be the world's foremost facility for nuclear fuel cycle research, technology development, and demonstration. The facility will also support the near-term mission to develop and demonstrate technology in support of fuel cycle needs identified by industry, and the long-term mission to retain and retain U.S. leadership in fuel cycle operations. The AFCF is essential to demonstrate a more proliferation-resistant fuel cycle and make long-term improvements in fuel cycle effectiveness, performance and economy.

  13. Reduced Availability of Sugar-Sweetened Beverages and Diet Soda Has a Limited Impact on Beverage Consumption Patterns in Maine High School Youth

    Science.gov (United States)

    Whatley Blum, Janet E.; Davee, Anne-Marie; Beaudoin, Christina M.; Jenkins, Paul L.; Kaley, Lori A.; Wigand, Debra A.

    2008-01-01

    Objective: To examine change in high school students' beverage consumption patterns pre- and post-intervention of reduced availability of sugar-sweetened beverages (SSB) and diet soda in school food venues. Design: A prospective, quasi-experimental, nonrandomized study design. Setting: Public high schools. Participants: A convenience sample from…

  14. A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression

    Directory of Open Access Journals (Sweden)

    Amsterdam Adam

    2006-06-01

    Full Text Available Abstract Background Craniofacial birth defects result from defects in cranial neural crest (NC patterning and morphogenesis. The vertebrate craniofacial skeleton is derived from cranial NC cells and the patterning of these cells occurs within the pharyngeal arches. Substantial efforts have led to the identification of several genes required for craniofacial skeletal development such as the endothelin-1 (edn1 signaling pathway that is required for lower jaw formation. However, many essential genes required for craniofacial development remain to be identified. Results Through screening a collection of insertional zebrafish mutants containing approximately 25% of the genes essential for embryonic development, we present the identification of 15 essential genes that are required for craniofacial development. We identified 3 genes required for hyomandibular development. We also identified zebrafish models for Campomelic Dysplasia and Ehlers-Danlos syndrome. To further demonstrate the utility of this method, we include a characterization of the wdr68 gene. We show that wdr68 acts upstream of the edn1 pathway and is also required for formation of the upper jaw equivalent, the palatoquadrate. We also present evidence that the level of wdr68 activity required for edn1 pathway function differs between the 1st and 2nd arches. Wdr68 interacts with two minibrain-related kinases, Dyrk1a and Dyrk1b, required for embryonic growth and myotube differentiation, respectively. We show that a GFP-Wdr68 fusion protein localizes to the nucleus with Dyrk1a in contrast to an engineered loss of function mutation Wdr68-T284F that no longer accumulated in the cell nucleus and failed to rescue wdr68 mutant animals. Wdr68 homologs appear to exist in all eukaryotic genomes. Notably, we found that the Drosophila wdr68 homolog CG14614 could substitute for the vertebrate wdr68 gene even though insects lack the NC cell lineage. Conclusion This work represents a systematic

  15. Exercise and a High Fat Diet Synergistically Increase the Pantothenic Acid Requirement in Rats.

    Science.gov (United States)

    Takahashi, Kei; Fukuwatari, Tsutomu; Shibata, Katsumi

    2015-01-01

    It is thought that both exercise and dietary composition increase the utilization of, and thus the requirement for, certain water-soluble vitamins. However, there have been no studies evaluating the combined impacts of exercise and dietary composition on vitamin utilization. In this experiment, rats were fed a pantothenic acid (PaA)-restricted (0.004 g PaA-Ca/kg diet) diet containing 5% (ordinary amount of dietary fat) or 20% fat (high fat), and were forced to swim until exhaustion every other day for 22 d. PaA status was assessed by urinary excretion, which reflects body stores of water-soluble vitamins. The urinary excretion of PaA in rats fed a 5% fat diet was not affected by swimming (5% fat + non-swimming vs. 5% fat + swim; p>0.05). Excretion of PaA was decreased by the high-fat diet (5% fat + non-swim vs. 20% fat + non-swim; pswim vs. 20% fat + swim; p<0.05). There was a significant interaction between exercise and a high-fat diet. Plasma PaA concentrations showed changes similar to those seen for urinary excretion. The experiment was then repeated using rats fed a PaA-sufficient (0.016 g PaA-Ca/kg diet) diet, and PaA excretion was again synergistically decreased by the combination of exercise and a high-fat diet (p<0.05). These results suggest that the combination of exercise and a high-fat diet synergistically increases the requirement for PaA.

  16. High Performance Computing and Storage Requirements for Nuclear Physics: Target 2017

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, Richard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wasserman, Harvey [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-04-30

    In April 2014, NERSC, ASCR, and the DOE Office of Nuclear Physics (NP) held a review to characterize high performance computing (HPC) and storage requirements for NP research through 2017. This review is the 12th in a series of reviews held by NERSC and Office of Science program offices that began in 2009. It is the second for NP, and the final in the second round of reviews that covered the six Office of Science program offices. This report is the result of that review

  17. High Performance Computing and Storage Requirements for Nuclear Physics: Target 2017

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, Richard; Wasserman, Harvey

    2015-01-20

    In April 2014, NERSC, ASCR, and the DOE Office of Nuclear Physics (NP) held a review to characterize high performance computing (HPC) and storage requirements for NP research through 2017. This review is the 12th in a series of reviews held by NERSC and Office of Science program offices that began in 2009. It is the second for NP, and the final in the second round of reviews that covered the six Office of Science program offices. This report is the result of that review

  18. The ATLAS Software Installation System v2: a highly available system to install and validate Grid and Cloud sites via Panda

    Science.gov (United States)

    De Salvo, A.; Kataoka, M.; Sanchez Pineda, A.; Smirnov, Y.

    2015-12-01

    The ATLAS Installation System v2 is the evolution of the original system, used since 2003. The original tool has been completely re-designed in terms of database backend and components, adding support for submission to multiple backends, including the original Workload Management Service (WMS) and the new PanDA modules. The database engine has been changed from plain MySQL to Galera/Percona and the table structure has been optimized to allow a full High-Availability (HA) solution over Wide Area Network. The servlets, running on each frontend, have been also decoupled from local settings, to allow an easy scalability of the system, including the possibility of an HA system with multiple sites. The clients can also be run in multiple copies and in different geographical locations, and take care of sending the installation and validation jobs to the target Grid or Cloud sites. Moreover, the Installation Database is used as source of parameters by the automatic agents running in CVMFS, in order to install the software and distribute it to the sites. The system is in production for ATLAS since 2013, having as main sites in HA the INFN Roma Tier 2 and the CERN Agile Infrastructure. The Light Job Submission Framework for Installation (LJSFi) v2 engine is directly interfacing with PanDA for the Job Management, the Atlas Grid Information System (AGIS) for the site parameter configurations, and CVMFS for both core components and the installation of the software itself. LJSFi2 is also able to use other plugins, and is essentially Virtual Organization (VO) agnostic, so can be directly used and extended to cope with the requirements of any Grid or Cloud enabled VO. In this work we will present the architecture, performance, status and possible evolutions to the system for the LHC Run2 and beyond.

  19. Compact Differential Evolution Light: High Performance Despite Limited Memory Requirement and Modest Computational Overhead

    Institute of Scientific and Technical Information of China (English)

    Giovanni Iacca; Fabio Caraffini; Ferrante Neri

    2012-01-01

    Compact algorithms are Estimation of Distribution Algorithms which mimic the behavior of population-based algorithms by means of a probabilistic representation of the population of candidate solutions.These algorithms have a similar behaviour with respect to population-based algorithms but require a much smaller memory.This feature is crucially important in some engineering applications,especially in robotics.A high performance compact algorithm is the compact Differential Evolution (cDE) algorithm.This paper proposes a novel implementation of cDE,namely compact Differential Evolution light (cDElight),to address not only the memory saving necessities but also real-time requirements.cDElight employs two novel algorithmic modifications for employing a smaller computational overhead without a performance loss,with respect to cDE.Numerical results,carried out on a broad set of test problems,show that cDElight,despite its minimal hardware requirements,does not deteriorate the performance of cDE and thus is competitive with other memory saving and population-based algorithms.An application in the field of mobile robotics highlights the usability and advantages of the proposed approach.

  20. Communication Requirements and Interconnect Optimization forHigh-End Scientific Applications

    Energy Technology Data Exchange (ETDEWEB)

    Kamil, Shoaib; Oliker, Leonid; Pinar, Ali; Shalf, John

    2007-11-12

    The path towards realizing peta-scale computing isincreasingly dependent on building supercomputers with unprecedentednumbers of processors. To prevent the interconnect from dominating theoverall cost of these ultra-scale systems, there is a critical need forhigh-performance network solutions whose costs scale linearly with systemsize. This work makes several unique contributions towards attaining thatgoal. First, we conduct one of the broadest studies to date of high-endapplication communication requirements, whose computational methodsinclude: finite-difference, lattice-bolzmann, particle in cell, sparselinear algebra, particle mesh ewald, and FFT-based solvers. Toefficiently collect this data, we use the IPM (Integrated PerformanceMonitoring) profiling layer to gather detailed messaging statistics withminimal impact to code performance. Using the derived communicationcharacterizations, we next present fit-trees interconnects, a novelapproach for designing network infrastructure at a fraction of thecomponent cost of traditional fat-tree solutions. Finally, we propose theHybrid Flexibly Assignable Switch Topology (HFAST) infrastructure, whichuses both passive (circuit) and active (packet) commodity switchcomponents to dynamically reconfigure interconnects to suit thetopological requirements of scientific applications. Overall ourexploration leads to a promising directions for practically addressingthe interconnect requirements of future peta-scale systems.

  1. Required developments towards ultra high pressure and temperature subsea tree system solutions

    Energy Technology Data Exchange (ETDEWEB)

    Queseth, Per-Olaf

    2010-07-01

    For the subsea High Pressure High Temperature oil and gas production systems, the primary challenge is to provide good, reliable solutions for HPHT reservoir exploitation based on an overview of parameters for already discovered potential fields. The paper will present a resume of Aker Solutions' previous development in this area exemplified with experiences from testing and operator observations during production start of HPHT fields in the North Sea. Further improvements are required to comply with the extreme pressures and temperatures sought to overcome. 'The Devil is in the details' is a very relevant proverb. A program to qualify subsea production X-mas trees for Ultra HPHT use will be presented with highlight on sealing systems, feed-through solutions and materials as well as impact on interfacing systems. Preliminary and intermediate analytical and test results will be presented and remaining activities summarised. (Author)

  2. Effects of High Dissolved Inorganic and Organic Carbon Availability on the Physiology of the Hard Coral Acropora millepora from the Great Barrier Reef.

    Directory of Open Access Journals (Sweden)

    Friedrich W Meyer

    Full Text Available Coral reefs are facing major global and local threats due to climate change-induced increases in dissolved inorganic carbon (DIC and because of land-derived increases in organic and inorganic nutrients. Recent research revealed that high availability of labile dissolved organic carbon (DOC negatively affects scleractinian corals. Studies on the interplay of these factors, however, are lacking, but urgently needed to understand coral reef functioning under present and near future conditions. This experimental study investigated the individual and combined effects of ambient and high DIC (pCO2 403 μatm/ pHTotal 8.2 and 996 μatm/pHTotal 7.8 and DOC (added as Glucose 0 and 294 μmol L-1, background DOC concentration of 83 μmol L-1 availability on the physiology (net and gross photosynthesis, respiration, dark and light calcification, and growth of the scleractinian coral Acropora millepora (Ehrenberg, 1834 from the Great Barrier Reef over a 16 day interval. High DIC availability did not affect photosynthesis, respiration and light calcification, but significantly reduced dark calcification and growth by 50 and 23%, respectively. High DOC availability reduced net and gross photosynthesis by 51% and 39%, respectively, but did not affect respiration. DOC addition did not influence calcification, but significantly increased growth by 42%. Combination of high DIC and high DOC availability did not affect photosynthesis, light calcification, respiration or growth, but significantly decreased dark calcification when compared to both controls and DIC treatments. On the ecosystem level, high DIC concentrations may lead to reduced accretion and growth of reefs dominated by Acropora that under elevated DOC concentrations will likely exhibit reduced primary production rates, ultimately leading to loss of hard substrate and reef erosion. It is therefore important to consider the potential impacts of elevated DOC and DIC simultaneously to assess real world

  3. Effect of P Availability on Temporal Dynamics of Carbon Allocation and Glomus intraradices High-Affinity P Transporter Gene Induction in Arbuscular Mycorrhiza

    Science.gov (United States)

    Olsson, Pål Axel; Hansson, Maria C.; Burleigh, Stephen H.

    2006-01-01

    Arbuscular mycorrhizal (AM) fungi depend on a C supply from the plant host and simultaneously provide phosphorus to the colonized plant. We therefore evaluated the influence of external P on C allocation in monoxenic Daucus carota-Glomus intraradices cultures in an AM symbiosis. Fungal hyphae proliferated from a solid minimal medium containing colonized roots into a C-free liquid minimal medium with high or low P availability. Roots and hyphae were harvested periodically, and the flow of C from roots to fungus was measured by isotope labeling. We also measured induction of a G. intraradices high-affinity P transporter to estimate fungal P demand. The prevailing hypothesis is that high P availability reduces mycorrhizal fungal growth, but we found that C flow to the fungus was initially highest at the high P level. Only at later harvests, after 100 days of in vitro culture, were C flow and fungal growth limited at high P availability. Thus, AM fungi can benefit initially from P-enriched environments in terms of plant C allocation. As expected, the P transporter induction was significantly greater at low P availability and greatest in very young mycelia. We found no direct link between C flow to the fungus and the P transporter transcription level, which indicates that a good C supply is not essential for induction of the high-affinity P transporter. We describe a mechanism by which P regulates symbiotic C allocation, and we discuss how this mechanism may have evolved in a competitive environment. PMID:16751522

  4. Policy Requirements and Factors of High-Level Radioactive Waste Management

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kang Myoung; Jeong, J. Y.; Ha, K. M. [Korea Energy Technology and Emergency Management Institute, Seoul (Korea, Republic of)

    2007-06-15

    Recently, the need of high-level radioactive waste policy including spent fuel management becomes serious due to the rapid increase in oil price, the nationalism of natural resources, and the environmental issues such as Tokyo protocol. Also, the policy should be established urgently to prepare the saturation of on-site storage capacity of spent fuel, the revision of 'Agreement for Cooperation-Concerning Civil Uses of Atomic Energy' between Korea and US, the anxiety for nuclear weapon proliferation, and R and D to reduce the amount of waste to be disposed. In this study, we performed case study of US, Japan, Canada and Finland, which have special laws and plans/roadmaps for high-level waste management, to draw the policy requirements to be considered in HLW management. Also, we reviewed social conflict issues experienced in our society, and summarized the factors affecting the political and social environment. These policy requirements and factors summarized in this study should be considered seriously in the process for public consensus and the policy making regarding HLW management. Finally, the following 4 action items were drawn to manage HLW successfully : - Continuous and systematic R and D activities to obtain reliable management technology - Promoting companies having specialty in HLW management - Nurturing experts and workforce - Drive the public consensus process

  5. Design requirements, challenges, and solutions for high-temperature falling particle receivers

    Science.gov (United States)

    Christian, Joshua; Ho, Clifford

    2016-05-01

    Falling particle receivers (FPR) utilize small particles as a heat collecting medium within a cavity receiver structure. Previous analysis for FPR systems include computational fluid dynamics (CFD), analytical evaluations, and experiments to determine the feasibility and achievability of this CSP technology. Sandia National Laboratories has fabricated and tested a 1 MWth FPR that consists of a cavity receiver, top hopper, bottom hopper, support structure, particle elevator, flux target, and instrumentation. Design requirements and inherent challenges were addressed to enable continuous operation of flowing particles under high-flux conditions and particle temperatures over 700 °C. Challenges include being able to withstand extremely high temperatures (up to 1200°C on the walls of the cavity), maintaining particle flow and conveyance, measuring temperatures and mass flow rates, filtering out debris, protecting components from direct flux spillage, and measuring irradiance in the cavity. Each of the major components of the system is separated into design requirements, associated challenges and corresponding solutions. The intent is to provide industry and researchers with lessons learned to avoid pitfalls and technical problems encountered during the development of Sandia's prototype particle receiver system at the National Solar Thermal Test Facility (NSTTF).

  6. Personal radiation detector at a high technology readiness level that satisfies DARPA's SN-13-47 and SIGMA program requirements

    Science.gov (United States)

    Ginzburg, D.; Knafo, Y.; Manor, A.; Seif, R.; Ghelman, M.; Ellenbogen, M.; Pushkarsky, V.; Ifergan, Y.; Semyonov, N.; Wengrowicz, U.; Mazor, T.; Kadmon, Y.; Cohen, Y.; Osovizky, A.

    2015-06-01

    There is a need to develop new personal radiation detector (PRD) technologies that can be mass produced. On August 2013, DARPA released a request for information (RFI) seeking innovative radiation detection technologies. In addition, on December 2013, a Broad Agency Announcement (BAA) for the SIGMA program was released. The RFI requirements focused on a sensor that should possess three main properties: low cost, high compactness and radioisotope identification capabilities. The identification performances should facilitate the detection of a hidden threat, ranging from special nuclear materials (SNM) to commonly used radiological sources. Subsequently, the BAA presented the specific requirements at an instrument level and provided a comparison between the current market status (state-of-the-art) and the SIGMA program objectives. This work presents an optional alternative for both the detection technology (sensor with communication output and without user interface) for DARPA's initial RFI and for the PRD required by the SIGMA program. A broad discussion is dedicated to the method proposed to fulfill the program objectives and to the selected alternative that is based on the PDS-GO design and technology. The PDS-GO is the first commercially available PRD that is based on a scintillation crystal optically coupled with a silicon photomultiplier (SiPM), a solid-state light sensor. This work presents the current performance of the instrument and possible future upgrades based on recent technological improvements in the SiPM design. The approach of utilizing the SiPM with a commonly available CsI(Tl) crystal is the key for achieving the program objectives. This approach provides the appropriate performance, low cost, mass production and small dimensions; however, it requires a creative approach to overcome the obstacles of the solid-state detector dark current (noise) and gain stabilization over a wide temperature range. Based on the presented results, we presume that

  7. Effects of High Dissolved Inorganic and Organic Carbon Availability on the Physiology of the Hard Coral Acropora millepora from the Great Barrier Reef

    Science.gov (United States)

    Meyer, Friedrich W.; Vogel, Nikolas; Diele, Karen; Kunzmann, Andreas; Uthicke, Sven; Wild, Christian

    2016-01-01

    Coral reefs are facing major global and local threats due to climate change-induced increases in dissolved inorganic carbon (DIC) and because of land-derived increases in organic and inorganic nutrients. Recent research revealed that high availability of labile dissolved organic carbon (DOC) negatively affects scleractinian corals. Studies on the interplay of these factors, however, are lacking, but urgently needed to understand coral reef functioning under present and near future conditions. This experimental study investigated the individual and combined effects of ambient and high DIC (pCO2 403 μatm/ pHTotal 8.2 and 996 μatm/pHTotal 7.8) and DOC (added as Glucose 0 and 294 μmol L-1, background DOC concentration of 83 μmol L-1) availability on the physiology (net and gross photosynthesis, respiration, dark and light calcification, and growth) of the scleractinian coral Acropora millepora (Ehrenberg, 1834) from the Great Barrier Reef over a 16 day interval. High DIC availability did not affect photosynthesis, respiration and light calcification, but significantly reduced dark calcification and growth by 50 and 23%, respectively. High DOC availability reduced net and gross photosynthesis by 51% and 39%, respectively, but did not affect respiration. DOC addition did not influence calcification, but significantly increased growth by 42%. Combination of high DIC and high DOC availability did not affect photosynthesis, light calcification, respiration or growth, but significantly decreased dark calcification when compared to both controls and DIC treatments. On the ecosystem level, high DIC concentrations may lead to reduced accretion and growth of reefs dominated by Acropora that under elevated DOC concentrations will likely exhibit reduced primary production rates, ultimately leading to loss of hard substrate and reef erosion. It is therefore important to consider the potential impacts of elevated DOC and DIC simultaneously to assess real world scenarios, as

  8. Effects of High Dissolved Inorganic and Organic Carbon Availability on the Physiology of the Hard Coral Acropora millepora from the Great Barrier Reef.

    Science.gov (United States)

    Meyer, Friedrich W; Vogel, Nikolas; Diele, Karen; Kunzmann, Andreas; Uthicke, Sven; Wild, Christian

    2016-01-01

    Coral reefs are facing major global and local threats due to climate change-induced increases in dissolved inorganic carbon (DIC) and because of land-derived increases in organic and inorganic nutrients. Recent research revealed that high availability of labile dissolved organic carbon (DOC) negatively affects scleractinian corals. Studies on the interplay of these factors, however, are lacking, but urgently needed to understand coral reef functioning under present and near future conditions. This experimental study investigated the individual and combined effects of ambient and high DIC (pCO2 403 μatm/ pHTotal 8.2 and 996 μatm/pHTotal 7.8) and DOC (added as Glucose 0 and 294 μmol L-1, background DOC concentration of 83 μmol L-1) availability on the physiology (net and gross photosynthesis, respiration, dark and light calcification, and growth) of the scleractinian coral Acropora millepora (Ehrenberg, 1834) from the Great Barrier Reef over a 16 day interval. High DIC availability did not affect photosynthesis, respiration and light calcification, but significantly reduced dark calcification and growth by 50 and 23%, respectively. High DOC availability reduced net and gross photosynthesis by 51% and 39%, respectively, but did not affect respiration. DOC addition did not influence calcification, but significantly increased growth by 42%. Combination of high DIC and high DOC availability did not affect photosynthesis, light calcification, respiration or growth, but significantly decreased dark calcification when compared to both controls and DIC treatments. On the ecosystem level, high DIC concentrations may lead to reduced accretion and growth of reefs dominated by Acropora that under elevated DOC concentrations will likely exhibit reduced primary production rates, ultimately leading to loss of hard substrate and reef erosion. It is therefore important to consider the potential impacts of elevated DOC and DIC simultaneously to assess real world scenarios, as

  9. The relationship between school characteristics and the availability of mental health and related health services in middle and high schools in the United States.

    Science.gov (United States)

    Slade, Eric P

    2003-01-01

    Problems related to mental illness are increasingly becoming the focal point of public concern over the safety and performance of schools, yet little is known about the availability and quality of school-based mental health services in the United States. In this article it is estimated that approximately 50% of US middle and high schools have any mental health counseling services available onsite and approximately 11% have mental health counseling, physical examinations, and substance abuse counseling available on-site. There are substantial differences in mental health counseling availability by region, urbanicity, and school size, with rural schools, schools in the Midwest and South regions, and small schools being least likely to offer mental health counseling. Multivariate estimates suggest that disparities between schools in the availability of mental health counseling and related health services may be partly explained by differences in access to Medicaid for financing of health services provided at school.

  10. Availability of healthy snack foods and beverages in stores near high-income urban, low-income urban, and rural elementary and middle schools in Oregon.

    Science.gov (United States)

    Findholt, Nancy E; Izumi, Betty T; Nguyen, Thuan; Pickus, Hayley; Chen, Zunqiu

    2014-08-01

    Food stores near schools are an important source of snacks for children. However, few studies have assessed availability of healthy snacks in these settings. The aim of this study was to assess availability of healthy snack foods and beverages in stores near schools and examine how availability of healthy items varied by poverty level of the school and rural-urban location. Food stores were selected based on their proximity to elementary/middle schools in three categories: high-income urban, low-income urban, and rural. Audits were conducted within the stores to assess the presence or absence of 48 items in single-serving sizes, including healthy beverages, healthy snacks, fresh fruits, and fresh vegetables. Overall, availability of healthy snack foods and beverages was low in all stores. However, there was significant cross-site variability in availability of several snack and fruit items, with stores near high-income urban schools having higher availability, compared to stores near low-income urban and/or rural schools. Stores near rural schools generally had the lowest availability, although several fruits were found more often in rural stores than in urban stores. There were no significant differences in availability of healthy beverages and fresh vegetables across sites. Availability of healthy snack foods and beverages was limited in stores near schools, but these limitations were more severe in stores proximal to rural and low-income schools. Given that children frequent these stores to purchase snacks, efforts to increase the availability of healthy products, especially in stores near rural and low-income schools, should be a priority.

  11. Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis

    Directory of Open Access Journals (Sweden)

    Hala S El-Wakil

    2013-01-01

    Full Text Available The objective of this study is to investigate the serum beta-2-microglobulin (B2MG and advanced oxidation protein products (AOPP as middle molecule uremic toxins and protein carbonyl (PCO as oxidative stress marker in uremic patients undergoing high-flux versus low-flux hemodialysis (HD and to correlate their levels to the erythropoietin requirements for those patients. Twenty patients on chronic low-flux HD were recruited in the study. At the start of the study, all patients underwent high-flux HD for eight weeks, followed by low-flux HD for two weeks as a washout period. The patients were then subjected to another eight weeks of low-flux HD. Blood samples were obtained at the beginning and at the end of the high-flux period and the low-flux period. The mean erythropoietin dose for patients using high-flux HD was significantly lower than that for low-flux HD (P = 0.0062. Post-high flux, the B2MG and PCO levels were significantly lower than the pre-high-flux levels (P = 0.026 and 0.0005, respectively, but no significant change was observed in AOPP (P = 0.68. Post-low flux, the B2MG, AOPP and PCO were significantly higher than the pre-low-flux levels (P = 0.0002, 0.021 and <0.0001, respectively. Post-low flux, the B2MG and PCO were significantly higher than the post-high-flux levels (P <0.0001, but no significant difference was observed in AOPP (P = 0.11. High-flux HD results in reduction of some of the middle molecule toxins and PCO levels better than low-flux HD, and is associated with a better response to erythropoietin.

  12. Conceptual waste package interim product specifications and data requirements for disposal of borosilicate glass defense high-level waste forms in salt geologic repositories

    Energy Technology Data Exchange (ETDEWEB)

    1983-06-01

    The conceptual waste package interim product specifications and data requirements presented are applicable specifically to the normal borosilicate glass product of the Defense Waste Processing Facility (DWPF). They provide preliminary numerical values for the defense high-level waste form parameters and properties identified in the waste form performance specification for geologic isolation in salt repositories. Subject areas treated include containment and isolation, operational period safety, criticality control, waste form/production canister identification, and waste package performance testing requirements. This document was generated for use in the development of conceptual waste package designs in salt. It will be revised as additional data, analyses, and regulatory requirements become available.

  13. Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening.

    Science.gov (United States)

    Damon, C; Luck, M; Toullec, L; Etienne, I; Buchler, M; Hurault de Ligny, B; Choukroun, G; Thierry, A; Vigneau, C; Moulin, B; Heng, A-E; Subra, J-F; Legendre, C; Monnot, A; Yartseva, A; Bateson, M; Laurent-Puig, P; Anglicheau, D; Beaune, P; Loriot, M A; Thervet, E; Pallet, N

    2017-04-01

    Any biochemical reaction underlying drug metabolism depends on individual gene-drug interactions and on groups of genes interacting together. Based on a high-throughput genetic approach, we sought to identify a set of covariant single-nucleotide polymorphisms predictive of interindividual tacrolimus (Tac) dose requirement variability. Tac blood concentrations (Tac C0 ) of 229 kidney transplant recipients were repeatedly monitored after transplantation over 3 mo. Given the high dimension of the genomic data in comparison to the low number of observations and the high multicolinearity among the variables (gene variants), we developed an original predictive approach that integrates an ensemble variable-selection strategy to reinforce the stability of the variable-selection process and multivariate modeling. Our predictive models explained up to 70% of total variability in Tac C0 per dose with a maximum of 44 gene variants (p-value <0.001 with a permutation test). These models included molecular networks of drug metabolism with oxidoreductase activities and the multidrug-resistant ABCC8 transporter, which was found in the most stringent model. Finally, we identified an intronic variant of the gene encoding SLC28A3, a drug transporter, as a key gene involved in Tac metabolism, and we confirmed it in an independent validation cohort. © 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.

  14. Data Handling for EO-Missions with High Data Rates Requiring Low Resources

    Science.gov (United States)

    Penné, B.; Tobehn, C.; Rathje, R.; Michalik, H.

    2008-08-01

    High spatial or spectral resolution optical or SAR Earth observation missions set requirements for high data rate and volume. The limited downlink bandwidth on the other hand can be overcome by recently new technolo- gies within the transmitter technology on one side and the data pre-processing and/or compression on-board on the other side. This advanced architecture for space- borne high speed payload data handling system (PDHS) is an important element to process more data with even smaller system to gain significant the overall system effectiveness. The PDHS chain introduces the advantages of channel link and IEEE 1355 space wire standards to provide scaleable redundancy and performance. The modules of the chain like on-board data processing (LEON proces- sor) feature data pre-processing, compression, and trun- cation of data to the area of interest as well as data stor- age, data formatting (CCSDS), data encryption and downlink. The system comprises also the complete ground test equipment for verification of the PDHS as stand-alone units, at subsystem level and for complete system tests during satellite AIV. The OHB-System experience gained from development of PDHS within three projects MSRS, KOMPSAT II and SAR-Lupe, form the baseline of our PDHS, that reaches several Gbit/s input rate and an output rate of about 500 up to 1000 Mbit/s using dual polarisation techniques at X-Band at considerable low resources.

  15. Comparing the Effects of Commercially Available and Custom-Made Video Prompting for Teaching Cooking Skills to High School Students with Autism

    Science.gov (United States)

    Mechling, Linda C.; Ayres, Kevin M.; Foster, Ashley L.; Bryant, Kathryn J.

    2013-01-01

    The study compared the effects of using commercially available and custom-made video prompts on the completion of cooking recipes by four high school age males with a diagnosis of autism. An adapted alternating treatments design with continuous baseline, comparison, final treatment, and best treatment condition was used to compare the two…

  16. High Efficient of the Intermolecular Radical Reactions through three-Component Carbo-Oximation Process using new ready available Sulfonyl oxime.

    Directory of Open Access Journals (Sweden)

    Shireen Mohammed

    2015-09-01

    Full Text Available Addition of functionalized carbon fragments across the olefinic π-system through a free-radical carbo-oximation process offers a straightforward access to valuable intermediates for organic synthesis. For this purpose, we designed a new protected sulfonyl oxime, which enable rapid radical addition with high yields under mild conditions.

  17. An Arabidopsis thaliana high-affinity molybdate transporter required for efficient uptake of molybdate from soil.

    Science.gov (United States)

    Tomatsu, Hajime; Takano, Junpei; Takahashi, Hideki; Watanabe-Takahashi, Akiko; Shibagaki, Nakako; Fujiwara, Toru

    2007-11-20

    Molybdenum (Mo) is a trace element essential for living organisms, however no molybdate transporter has been identified in eukaryotes. Here, we report the identification of a molybdate transporter, MOT1, from Arabidopsis thaliana. MOT1 is expressed in both roots and shoots, and the MOT1 protein is localized, in part, to plasma membranes and to vesicles. MOT1 is required for efficient uptake and translocation of molybdate and for normal growth under conditions of limited molybdate supply. Kinetics studies in yeast revealed that the K(m) value of MOT1 for molybdate is approximately 20 nM. Furthermore, Mo uptake by MOT1 in yeast was not affected by coexistent sulfate, and MOT1 did not complement a sulfate transporter-deficient yeast mutant strain. These data confirmed that MOT1 is specific for molybdate and that the high affinity of MOT1 allows plants to obtain scarce Mo from soil.

  18. Dissipative particle dynamics of diffusion-NMR requires high Schmidt-numbers

    Science.gov (United States)

    Azhar, Mueed; Greiner, Andreas; Korvink, Jan G.; Kauzlarić, David

    2016-06-01

    We present an efficient mesoscale model to simulate the diffusion measurement with nuclear magnetic resonance (NMR). On the level of mesoscopic thermal motion of fluid particles, we couple the Bloch equations with dissipative particle dynamics (DPD). Thereby we establish a physically consistent scaling relation between the diffusion constant measured for DPD-particles and the diffusion constant of a real fluid. The latter is based on a splitting into a centre-of-mass contribution represented by DPD, and an internal contribution which is not resolved in the DPD-level of description. As a consequence, simulating the centre-of-mass contribution with DPD requires high Schmidt numbers. After a verification for fundamental pulse sequences, we apply the NMR-DPD method to NMR diffusion measurements of anisotropic fluids, and of fluids restricted by walls of microfluidic channels. For the latter, the free diffusion and the localisation regime are considered.

  19. Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate.

    Science.gov (United States)

    Lazzara, Silvia; Militello, Marcello; Carrubba, Alessandra; Napoli, Edoardo; Saia, Sergio

    2016-12-20

    St. John's Wort (Hypericum perforatum) is a perennial herb able to produce water-soluble active ingredients (a.i.), mostly in flowers, with a wide range of medicinal and biotechnological uses. However, information about the ability of arbuscular mycorrhizal fungi (AMF) to affect its biomass accumulation, flower production, and concentration of a.i. under contrasting nutrient availability is still scarce. In the present experiment, we evaluated the role of AMF on growth, flower production, and concentration of bioactive secondary metabolites (hypericin, pseudohypericin, and hyperforin) of H. perforatum under contrasting P availability. AMF stimulated the production of aboveground biomass under low P conditions and increased the production of root biomass. AMF almost halved the number of flowers per plant by means of a reduction of the number of flower-bearing stems per plant under high P availability and through a lower number of flowers per stem in the low-P treatment. Flower hyperforin concentration was 17.5% lower in mycorrhizal than in non-mycorrhizal plants. On the contrary, pseudohypericin and hypericin concentrations increased by 166.8 and 279.2%, respectively, with AMF under low P availability, whereas no effect of AMF was found under high P availability. These results have implications for modulating the secondary metabolite production of H. perforatum. However, further studies are needed to evaluate the competition for photosynthates between AMF and flowers at different nutrient availabilities for both plant and AM fungus.

  20. High resolution x-ray microtomography of biological samples: Requirements and strategies for satisfying them

    Energy Technology Data Exchange (ETDEWEB)

    Loo, B.W. Jr. [Univ. of California, San Francisco, CA (United States)]|[Univ. of California, Davis, CA (United States)]|[Lawrence Berkeley National Lab., CA (United States); Rothman, S.S. [Univ. of California, San Francisco, CA (United States)]|[Lawrence Berkeley National Lab., CA (United States)

    1997-02-01

    High resolution x-ray microscopy has been made possible in recent years primarily by two new technologies: microfabricated diffractive lenses for soft x-rays with about 30-50 nm resolution, and high brightness synchrotron x-ray sources. X-ray microscopy occupies a special niche in the array of biological microscopic imaging methods. It extends the capabilities of existing techniques mainly in two areas: a previously unachievable combination of sub-visible resolution and multi-micrometer sample size, and new contrast mechanisms. Because of the soft x-ray wavelengths used in biological imaging (about 1-4 nm), XM is intermediate in resolution between visible light and electron microscopies. Similarly, the penetration depth of soft x-rays in biological materials is such that the ideal sample thickness for XM falls in the range of 0.25 - 10 {mu}m, between that of VLM and EM. XM is therefore valuable for imaging of intermediate level ultrastructure, requiring sub-visible resolutions, in intact cells and subcellular organelles, without artifacts produced by thin sectioning. Many of the contrast producing and sample preparation techniques developed for VLM and EM also work well with XM. These include, for example, molecule specific staining by antibodies with heavy metal or fluorescent labels attached, and sectioning of both frozen and plastic embedded tissue. However, there is also a contrast mechanism unique to XM that exists naturally because a number of elemental absorption edges lie in the wavelength range used. In particular, between the oxygen and carbon absorption edges (2.3 and 4.4 nm wavelength), organic molecules absorb photons much more strongly than does water, permitting element-specific imaging of cellular structure in aqueous media, with no artifically introduced contrast agents. For three-dimensional imaging applications requiring the capabilities of XM, an obvious extension of the technique would therefore be computerized x-ray microtomography (XMT).

  1. Simulating future supply of and requirements for human resources for health in high-income OECD countries.

    Science.gov (United States)

    Tomblin Murphy, Gail; Birch, Stephen; MacKenzie, Adrian; Rigby, Janet

    2016-12-12

    As part of efforts to inform the development of a global human resources for health (HRH) strategy, a comprehensive methodology for estimating HRH supply and requirements was described in a companion paper. The purpose of this paper is to demonstrate the application of that methodology, using data publicly available online, to simulate the supply of and requirements for midwives, nurses, and physicians in the 32 high-income member countries of the Organisation for Economic Co-operation and Development (OECD) up to 2030. A model combining a stock-and-flow approach to simulate the future supply of each profession in each country-adjusted according to levels of HRH participation and activity-and a needs-based approach to simulate future HRH requirements was used. Most of the data to populate the model were obtained from the OECD's online indicator database. Other data were obtained from targeted internet searches and documents gathered as part of the companion paper. Relevant recent measures for each model parameter were found for at least one of the included countries. In total, 35% of the desired current data elements were found; assumed values were used for the other current data elements. Multiple scenarios were used to demonstrate the sensitivity of the simulations to different assumed future values of model parameters. Depending on the assumed future values of each model parameter, the simulated HRH gaps across the included countries could range from shortfalls of 74 000 midwives, 3.2 million nurses, and 1.2 million physicians to surpluses of 67 000 midwives, 2.9 million nurses, and 1.0 million physicians by 2030. Despite important gaps in the data publicly available online and the short time available to implement it, this paper demonstrates the basic feasibility of a more comprehensive, population needs-based approach to estimating HRH supply and requirements than most of those currently being used. HRH planners in individual countries, working with their

  2. High level waste storage tanks 242-A evaporator standards/requirement identification document

    Energy Technology Data Exchange (ETDEWEB)

    Biebesheimer, E.

    1996-01-01

    This document, the Standards/Requirements Identification Document (S/RIDS) for the subject facility, represents the necessary and sufficient requirements to provide an adequate level of protection of the worker, public health and safety, and the environment. It lists those source documents from which requirements were extracted, and those requirements documents considered, but from which no requirements where taken. Documents considered as source documents included State and Federal Regulations, DOE Orders, and DOE Standards

  3. Machine Protection: Availability for Particle Accelerators

    CERN Document Server

    Apollonio, Andrea; Schmidt, Ruediger

    2015-03-16

    Machine availability is a key indicator for the performance of the next generation of particle accelerators. Availability requirements need to be carefully considered during the design phase to achieve challenging objectives in different fields, as e.g. particle physics and material science. For existing and future High-Power facilities, such as ESS (European Spallation Source) and HL-LHC (High-Luminosity LHC), operation with unprecedented beam power requires highly dependable Machine Protection Systems (MPS) to avoid any damage-induced downtime. Due to the high complexity of accelerator systems, finding the optimal balance between equipment safety and accelerator availability is challenging. The MPS architecture, as well as the choice of electronic components, have a large influence on the achievable level of availability. In this thesis novel methods to address the availability of accelerators and their protection systems are presented. Examples of studies related to dependable MPS architectures are given i...

  4. On-pump beating heart coronary surgery for high risk patients requiring emergency multiple coronary artery bypass grafting

    Directory of Open Access Journals (Sweden)

    von Segesser Ludwig K

    2008-07-01

    Full Text Available Abstract Background Cardiopulmonary bypass (CPB with aortic cross-clamping and cardioplegic arrest remains the method of choice for patients requiring standard myocardial revascularization. Therefore, very high-risk patients presenting with acute coronary syndrome, unstable angina, onset of cardiac decompensation and requiring emergency multiple myocardial revascularization, can have a poor outcome. The on-pump beating heart technique can reduce the mortality and the morbidity in such a selected group of patients and this report describes our clinical experience. Methods Out of 290 patients operated for CABG from January 2005 to January 2006, 25 (8.6% selected high-risk patients suffering from life threatening coronary syndrome (mean age 69 ± 7 years and requiring emergency multiple myocardial revascularization, underwent on-pump beating heart surgery. The mean pre-operative left ventricle ejection fraction (LVEF was 27 ± 8%. The majority of them (88% suffered of tri-vessel coronary disease and 6 (24% had a left main stump disease. Nine patients (35% were on severe cardiac failure and seven among them (28% received a pre-operative intra-aortic balloon pump. The pre-operative EuroScore rate was equal or above 8 in 18 patients (73%. Results All patients underwent on-pump-beating heart coronary revascularization. The mean number of graft/patient was 2.9 ± 0.6 and the internal mammary artery was used in 23 patients (92%. The mean CPB time was 84 ± 19 minutes. Two patients died during the recovery stay in the intensive care unit, and there were no postoperative myocardial infarctions between the survivors. Eight patients suffered of transitorily renal failure and 1 patient developed a sternal wound infection. The mean hospital stay was 12 ± 7 days. The follow-up was complete for all 23 patients survived at surgery and the mean follow-up time was 14 ± 5 months. One patient died during the follow-up for cardiac arrest and 2 patients required an

  5. A Symmetrical, Planar SOFC Design for NASA's High Specific Power Density Requirements

    Science.gov (United States)

    Cable, Thomas L.; Sofie, Stephen W.

    2007-01-01

    Solid oxide fuel cell (SOFC) systems for aircraft applications require an order of magnitude increase in specific power density (1.0 kW/kg) and long life. While significant research is underway to develop anode supported cells which operate at temperatures in the range of 650-800 C, concerns about Cr-contamination from the metal interconnect may drive the operating temperature down further, to 750 C and lower. Higher temperatures, 900-1000 C, are more favorable for SOFC stacks to achieve specific power densities of 1.0 kW/kg. Since metal interconnects are not practical at these high temperatures and can account for up to 75% of the weight of the stack, NASA is pursuing a design that uses a thin, LaCrO3-based ceramic interconnect that incorporates gas channels into the electrodes. The bi-electrode supported cell (BSC) uses porous YSZ scaffolds, on either side of a 10-20 microns electrolyte. The porous support regions are fabricated with graded porosity using the freeze-tape casting process which can be tailored for fuel and air flow. Removing gas channels from the interconnect simplifies the stack design and allows the ceramic interconnect to be kept thin, on the order of 50 -100 microns. The YSZ electrode scaffolds are infiltrated with active electrode materials following the high temperature sintering step. The NASA-BSC is symmetrical and CTE matched, providing balanced stresses and favorable mechanical properties for vibration and thermal cycling.

  6. High Hardware Utilization and Low Memory Block Requirement Decoding of QC-LDPC Codes

    Institute of Scientific and Technical Information of China (English)

    ZHAO Ling; LIU Rongke; HOU Yi; ZHANG Xiaolin

    2012-01-01

    This paper presents a simple yet effective decoding for general quasi-cyclic low-density parity-check (QC-LDPC) codes,which not only achieves high hardware utility efficiency (HUE),but also brings about great memory block reduction without any performance degradation.The main idea is to split the check matrix into several row blocks,then to perform the improved message passing computations sequentially block by block.As the decoding algorithm improves,the sequential tie between the two-phase computations is broken,so that the two-phase computations can be overlapped which bring in high HUE.Two overlapping schemes are also presented,each of which suits a different situation.In addition,an efficient memory arrangement scheme is proposed to reduce the great memory block requirement of the LDPC decoder.As an example,for the 0.4 rate LDPC code selected from Chinese Digital TV Terrestrial Broadcasting (DTTB),our decoding saves over 80% memory blocks compared with the conventional decoding,and the decoder achieves 0.97 HUE.Finally,the 0.4 rate LDPC decoder is implemented on an FPGA device EP2S30 (speed grade-5).Using 8 row processing units,the decoder can achieve a maximum net throughput of 28.5 Mbps at 20 iterations.

  7. High environmental temperature increases glucose requirement in the developing chicken embryo.

    Directory of Open Access Journals (Sweden)

    Roos Molenaar

    Full Text Available Environmental conditions during the perinatal period influence metabolic and developmental processes in mammals and avian species, which could impact pre- and postnatal survival and development. The current study investigated the effect of eggshell temperature (EST on glucose metabolism in broiler chicken embryos. Broiler eggs were incubated at a high (38.9°C or normal (37.8°C EST from day 10.5 of incubation onward and were injected with a bolus of [U-(13C]glucose in the chorio-allantoic fluid at day 17.5 of incubation. After [U-(13C]glucose administration, (13C enrichment was determined in intermediate pools and end-products of glucose metabolism. Oxidation of labeled glucose occurred for approximately 3 days after injection. Glucose oxidation was higher in the high than in the normal EST treatment from day 17.6 until 17.8 of incubation. The overall recovery of (13CO2 tended to be 4.7% higher in the high than in the normal EST treatment. An increase in EST (38.9°C vs 37.8°C increased (13C enrichment in plasma lactate at day 17.8 of incubation and (13C in hepatic glycogen at day 18.8 of incubation. Furthermore, high compared to normal EST resulted in a lower yolk-free body mass at day 20.9 (-2.74 g and 21.7 (-3.81 g of incubation, a lower hepatic glycogen concentration at day 18.2 (-4.37 mg/g and 18.8 (-4.59 mg/g of incubation, and a higher plasma uric acid concentration (+2.8 mg/mL/+43% at day 21.6 of incubation. These results indicate that the glucose oxidation pattern is relatively slow, but the intensity increased consistently with an increase in developmental stage of the embryo. High environmental temperatures in the perinatal period of chicken embryos increased glucose oxidation and decreased hepatic glycogen prior to the hatching process. This may limit glucose availability for successful hatching and could impact body development, probably by increased gluconeogenesis from glucogenic amino acids to allow anaerobic glycolysis.

  8. When is high-Ca+ microdomain required for mitochondrial Ca+ uptake?

    Science.gov (United States)

    Spät, A; Fülöp, L; Koncz, P; Szanda, G

    2009-01-01

    Ca(2+) release from IP(3)-sensitive stores in the endoplasmic reticulum (ER) induced by Ca(2+)-mobilizing agonists generates high-Ca(2+) microdomains between ER vesicles and neighbouring mitochondria. Here we present a model that describes when such microdomains are required and when submicromolar [Ca(2+)] is sufficient for mitochondrial Ca(2+) uptake. Mitochondrial Ca(2+) uptake rate in angiotensin II-stimulated H295R adrenocortical cells correlates with the proximity between ER vesicles and the mitochondrion, reflecting the uptake promoting effect of high-Ca(2+) peri-mitochondrial microdomains. Silencing or inhibition of p38 mitogen-activated protein kinase (MAPK) or inhibition of the novel isoforms of protein kinase C enhances mitochondrial Ca(2+) uptake and abolishes the positive correlation between Ca(2+) uptake and ER-mitochondrion proximity. Inhibition of protein phosphatases attenuates mitochondrial Ca(2+) uptake and also abolishes its positive correlation with ER-mitochondrion proximity. We postulate that during IP(3)-induced Ca(2+) release, Ca(2+) uptake is confined to ER-close mitochondria, because of the simultaneous activation of the protein kinases. Attenuation of Ca(2+) uptake prevents Ca(2+) overload of mitochondria and thus protects the cell against apoptosis. On the other hand, all the mitochondria accumulate Ca(2+) at a non-inhibited rate during physiological Ca(2+) influx through the plasma membrane. Membrane potential is higher in ER-distant mitochondria, providing a bigger driving force for Ca(2+) uptake. Our model explains why comparable mitochondrial Ca(2+) signals are formed in response to K(+) and angiotensin II (equipotent in respect to global cytosolic Ca(2+) signals), although only the latter generates high-Ca(2+) microdomains.

  9. Considerations regarding neuropsychiatric nutritional requirements for intakes of omega-3 highly unsaturated fatty acids.

    Science.gov (United States)

    Hibbeln, Joseph R; Davis, John M

    2009-01-01

    Adverse neurodevelopmental and neuropsychiatric outcomes have been established as signs of nutrient deficiencies and may be applicable to insufficient dietary intakes of omega-3 highly unsaturated fatty acids (n-3 HUFAs). Consider if statistical definitions for Daily Reference Intakes can be applied to n-3 HUFAs intakes during pregnancy for maternal and neurodevelopmental deficiencies. Data were prospectively collected from women during pregnancy and children up to age 8 years participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). Statistical analyses took social and lifestyle factors into account. During pregnancy, n-3 HUFA intakes from seafood that putatively meet statistical definitions of an estimated average requirement ranged from 0.05 to 0.06 en% (111-139 mg/d/2000 Cal) for suboptimal fine motor control at 42 m and 0.065-0.08 en% (114-181 mg/d/2000 Cal) for suboptimal verbal IQ at age 8 years and 0.18-0.22 en% (389-486 mg/d/2000 Cal) for maternal depression at 32 weeks. Intakes of n-3 ranging from 0.2 to 0.41 en% (445-917 mg/d/2000 Cal) prevented both increased risk of maternal depression and adverse neurodevelopmental outcomes for children among 97.5% of the population. No upper limit for safety was found. During pregnancy, a n-3 HUFA intake of 0.40 en% (900 mg/d/2000 Cal) from seafood is likely to meet the nutritional requirements for 97.5% of the mothers and children of this population. These considerations do not constitute DRI's for docosahexaenoic acid and n-3 HUFAs, but may contribute to their formulation.

  10. Available transmission capacity assessment

    Directory of Open Access Journals (Sweden)

    Škokljev Ivan

    2012-01-01

    Full Text Available Effective power system operation requires the analysis of vast amounts of information. Power market activities expose power transmission networks to high-level power transactions that threaten normal, secure operation of the power system. When there are service requests for a specific sink/source pair in a transmission system, the transmission system operator (TSO must allocate the available transfer capacity (ATC. It is common that ATC has a single numerical value. Additionally, the ATC must be calculated for the base case configuration of the system, while generation dispatch and topology remain unchanged during the calculation. Posting ATC on the internet should benefit prospective users by aiding them in formulating their requests. However, a single numerical value of ATC offers little for prospect for analysis, planning, what-if combinations, etc. A symbolic approach to the power flow problem (DC power flow and ATC offers a numerical computation at the very end, whilst the calculation beforehand is performed by using symbols for the general topology of the electrical network. Qualitative analysis of the ATC using only qualitative values, such as increase, decrease or no change, offers some new insights into ATC evaluation, multiple transactions evaluation, value of counter-flows and their impact etc. Symbolic analysis in this paper is performed after the execution of the linear, symbolic DC power flow. As control variables, the mathematical model comprises linear security constraints, ATC, PTDFs and transactions. The aim is to perform an ATC sensitivity study on a five nodes/seven lines transmission network, used for zonal market activities tests. A relatively complicated environment with twenty possible bilateral transactions is observed.

  11. Acute high fat diet consumption activates the mesolimbic circuit and requires orexin signaling in a mouse model.

    Directory of Open Access Journals (Sweden)

    Spring Valdivia

    Full Text Available Overconsumption of palatable energy-dense foods has negative health implications and it is associated with obesity and several eating disorders. Currently, little is known about the neuronal circuitries activated by the acute ingestion of a rewarding stimulus. Here, we used a combination of immunohistochemistry, pharmacology and neuronal tracing analyses to examine the role of the mesolimbic system in general, and the orexin neurons in particular, in a simple experimental test in which naïve mice are allowed to spontaneously eat a pellet of a high fat diet (HFD for 2 h. We found that acute HFD activates c-Fos expression in several reward-related brain areas, including the ventral tegmental area (VTA, nucleus accumbens, central amygdala and lateral hypothalamic area. We also found that: i- HFD-mediated orosensory stimulation was required for the mesolimbic pathway activation, ii- acute HFD differentially activates dopamine neurons of the paranigral, parabrachial pigmented and interfascicular sub-regions of the VTA, and iii- orexin neurons of the lateral hypothalamic area are responsive to acute HFD. Moreover, orexin signaling blockade, with the orexin 1 receptor antagonist SB-334867, reduces acute HFD consumption and c-Fos induction in the VTA but not in the other mesolimbic nuclei under study. Finally, we found that most orexin neurons responsive to acute HFD innervate the VTA. Our results show that acute HFD consumption recruits the mesolimbic system and that the full manifestation of this eating behavior requires the activation of orexin signaling.

  12. High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound

    Science.gov (United States)

    Schumann, Roman; Natov, Nikola S; Rocuts-Martinez, Klifford A; Finkelman, Matthew D; Phan, Tom V; Hegde, Sanjay R; Knapp, Robert M

    2016-01-01

    AIM To examine whether high-flow nasal oxygen (HFNO) availability influences the use of general anesthesia (GA) in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) and associated outcomes. METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras (era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era (era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively. RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P sedation was significantly higher in era 2 compared to era 3 (P sedation (P ≤ 0.007) as was the anesthesia-only time (P ≤ 0.001). CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. PMID:28058020

  13. Natural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at High Temperatures in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Wangsheng Zhu

    2015-05-01

    Full Text Available Plants are highly sensitive to environmental changes and even small variations in ambient temperature have severe consequences on their growth and development. Temperature affects multiple aspects of plant development, but the processes and mechanisms underlying thermo-sensitive growth responses are mostly unknown. Here we exploit natural variation in Arabidopsis thaliana to identify and characterize novel components and processes mediating thermo-sensitive growth responses in plants. Phenotypic screening of wild accessions identified several strains displaying pleiotropic growth defects, at cellular and organism levels, specifically at high ambient temperatures. Positional cloning and characterization of the underlying gene revealed that ICARUS1 (ICA1, which encodes a protein of the tRNAHis guanylyl transferase (Thg1 superfamily, is required for plant growth at high temperatures. Transcriptome and gene marker analyses together with DNA content measurements show that ICA1 loss-of-function results in down regulation of cell cycle associated genes at high temperatures, which is linked with a block in G2/M transition and endoreduplication. In addition, plants with mutations in ICA1 show enhanced sensitivity to DNA damage. Characterization of additional strains that carry lesions in ICA1, but display normal growth, shows that alternative splicing is likely to alleviate the deleterious effects of some natural mutations. Furthermore, analyses of worldwide and regional collections of natural accessions indicate that ICA1 loss-of-function has arisen several times independently, and that these occur at high frequency in some local populations. Overall our results suggest that ICA1-mediated-modulation of fundamental processes such as tRNAHis maturation, modify plant growth responses to temperature changes in a quantitative and reversible manner, in natural populations.

  14. Opportunities and requirements for experimentation at high energy e/sup +/e/sup /minus// collider

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, C.; Baltay, C.; Barklow, T.L.; Burchat, P.R.; Burke, D.L.; Cooper, A.R.; Dib, C.; Feldman, G.J.; Gunion, J.F.; Haber, H.E.

    1988-05-01

    Over the past fifteen years of high-energy physics, electron-positron annihilation has been the most productive of all reactions probing the fundamental interactions. The e/sup +/e/sup /minus// annihilation process is unique in offering at the same time copious production of novel particles, low backgrounds from more conventional physics, and the most efficient use of the energy which an accelerator provides. These features have allowed the detailed characterization of the charm and bottom quark-antiquark systems and the unambiguous discovery of gluon jets---the crucial ingredients in the establishment of Quantum Chromodynamics as the correct theory of the strong interactions---as well as the discovery of the tau lepton and confirmation of the weak and electromagnetic properties of all the quarks and leptons at high energy. Over the past few years, experiments will begin at SLC and LEP, and we anticipate new discoveries from the detailed study of the Z/sup 0/ resonance. It is time, then to begin to think out how one might continue this mode experimentation to still higher energies. This document is the report of a committee convened by the Director of SLAC, Burton Richter, to set out the major physics goals of an e/sup +/e/sup /minus// collider in the energy range 600 GeV-1 TeV, corresponding to the next feasible step in accelerator technology. The committee was charged with the task of outlining the main experiments that such a collider might carry out and the requirements which those experiments place on the accelerator design. 106 refs., 105 figs., 13 tabs.

  15. Meeting the security requirements of electronic medical records in the ERA of high-speed computing.

    Science.gov (United States)

    Alanazi, H O; Zaidan, A A; Zaidan, B B; Kiah, M L Mat; Al-Bakri, S H

    2015-01-01

    This study has two objectives. First, it aims to develop a system with a highly secured approach to transmitting electronic medical records (EMRs), and second, it aims to identify entities that transmit private patient information without permission. The NTRU and the Advanced Encryption Standard (AES) cryptosystems are secured encryption methods. The AES is a tested technology that has already been utilized in several systems to secure sensitive data. The United States government has been using AES since June 2003 to protect sensitive and essential information. Meanwhile, NTRU protects sensitive data against attacks through the use of quantum computers, which can break the RSA cryptosystem and elliptic curve cryptography algorithms. A hybrid of AES and NTRU is developed in this work to improve EMR security. The proposed hybrid cryptography technique is implemented to secure the data transmission process of EMRs. The proposed security solution can provide protection for over 40 years and is resistant to quantum computers. Moreover, the technique provides the necessary evidence required by law to identify disclosure or misuse of patient records. The proposed solution can effectively secure EMR transmission and protect patient rights. It also identifies the source responsible for disclosing confidential patient records. The proposed hybrid technique for securing data managed by institutional websites must be improved in the future.

  16. Selection for high and low oxygen consumption-induced differences in maintenance energy requirements of mice.

    Science.gov (United States)

    Darhan, Hongyu; Kikusato, Motoi; Toyomizu, Masaaki; Roh, Sang-Gun; Katoh, Kazuo; Sato, Masahiro; Suzuki, Keiichi

    2017-07-01

    Maintenance energy requirements (MER) of mice selected for high (H) or low (L) oxygen consumption (OC) were compared. Forty-four mice from H and L OC lines were weaned at 3 weeks and divided into four experimental groups: group A were sacrificed at 4 weeks; group B were fed ad libitum, and groups C and D were fed 2.8 and 2.4 g/day, respectively, from 4 to 8 weeks of age. Groups B-D were sacrificed at 8 weeks. Chemical components were estimated for all groups. MER was estimated using a model that partitioned metabolizable energy intake into that used for maintenance, and protein and fat deposition. The feed conversion ratio for the B group was significantly higher in the H than in the L line. Feed intake for metabolic energy content per metabolic body size was significantly also higher in the H line, whereas accumulated energy content per metabolic body size was significantly higher in the L line. MER of the H line was greater than that of the L line (P < 0.10). These results suggest that selection for H or L OC produced differences in chemical components, feed efficiency, and MER between the H and L lines. © 2016 Japanese Society of Animal Science.

  17. High-level waste storage tank farms/242-A evaporator Standards/Requirements Identification Document (S/RID)

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    The High-Level Waste Storage Tank Farms/242-A Evaporator Standards/Requirements Identification Document (S/RID) is contained in multiple volumes. This document (Volume 3) presents the standards and requirements for the following sections: Safeguards and Security, Engineering Design, and Maintenance.

  18. Leadership in organizations with high security and reliability requirements; Liderazgo en organizaciones con altos requisitos de seguridad y fiabilidad

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, F.

    2013-07-01

    Developing leadership skills in organizations is the key to ensure the sustain ability of excellent results in industries with high requirements safety and reliability. In order to have a model of leadership development specific to this type of organizations, Tecnatom in 2011, we initiated a project internal, to find and adapt a competency model to these requirements.

  19. High-level waste storage tank farms/242-A evaporator Standards/Requirements Identification Document (S/RID), Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    The High-Level Waste Storage Tank Farms/242-A Evaporator Standards/Requirements Document (S/RID) is contained in multiple volumes. This document (Volume 2) presents the standards and requirements for the following sections: Quality Assurance, Training and Qualification, Emergency Planning and Preparedness, and Construction.

  20. High-level waste storage tank farms/242-A evaporator Standards/Requirements Identification Document (S/RID), Volume 5

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    The High-Level Waste Storage Tank Farms/242-A Evaporator Standards/Requirements Identification Document (S/RID) is contained in multiple volumes. This document (Volume 5) outlines the standards and requirements for the Fire Protection and Packaging and Transportation sections.

  1. High level waste storage tank farms/242-A evaporator Standards/Requirements Identification Document (S/RID), Volume 6

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    The High-Level Waste Storage Tank Farms/242-A Evaporator Standards/Requirements Identification Document (S/RID) is contained in multiple volumes. This document (Volume 6) outlines the standards and requirements for the sections on: Environmental Restoration and Waste Management, Research and Development and Experimental Activities, and Nuclear Safety.

  2. High-level waste storage tank farms/242-A evaporator Standards/Requirements Identification Document (S/RID), Volume 4

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    The High-Level Waste Storage Tank Farms/242-A Evaporator Standards/Requirements Identification Document (S/RID) is contained in multiple volumes. This document (Volume 4) presents the standards and requirements for the following sections: Radiation Protection and Operations.

  3. Functions and requirements document for interim store solidified high-level and transuranic waste

    Energy Technology Data Exchange (ETDEWEB)

    Smith-Fewell, M.A., Westinghouse Hanford

    1996-05-17

    The functions, requirements, interfaces, and architectures contained within the Functions and Requirements (F{ampersand}R) Document are based on the information currently contained within the TWRS Functions and Requirements database. The database also documents the set of technically defensible functions and requirements associated with the solidified waste interim storage mission.The F{ampersand}R Document provides a snapshot in time of the technical baseline for the project. The F{ampersand}R document is the product of functional analysis, requirements allocation and architectural structure definition. The technical baseline described in this document is traceable to the TWRS function 4.2.4.1, Interim Store Solidified Waste, and its related requirements, architecture, and interfaces.

  4. Requirements for high quality X-ray spectroscopy in an Explorer class mission

    Science.gov (United States)

    Cash, W. C., Jr.

    1981-01-01

    Through the use of simulated X-ray spectra the question of instrument requirements for a spectrograph that could significantly advance X-ray astronomy is addressed. It it concluded that resolution (lambda/delta lambda) in the range of 200 to 500, and effective collecting area in excess of 200 sq cm are required. One design, based on the objective reflection grating concept, which would meet these stringent requirements in an Explorer class mission is presented.

  5. Central serotonin transporter availability in highly obese individuals compared with non-obese controls: A [{sup 11}C] DASB positron emission tomography study

    Energy Technology Data Exchange (ETDEWEB)

    Hesse, Swen; Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Integrated Research and Treatment Centre Adiposity Diseases Leipzig, Leipzig (Germany); Rullmann, Michael [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Integrated Research and Treatment Centre Adiposity Diseases Leipzig, Leipzig (Germany); Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Leipzig (Germany); Luthardt, Julia; Becker, Georg-Alexander; Bresch, Anke; Patt, Marianne; Meyer, Philipp M. [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Winter, Karsten [University of Leipzig, Centre for Translational Regenerative Medicine, Leipzig (Germany); University of Leipzig, Institute for Medical Informatics, Statistics, and Epidemiology, Leipzig (Germany); Hankir, Mohammed K.; Zientek, Franziska; Reissig, Georg; Drabe, Mandy [Integrated Research and Treatment Centre Adiposity Diseases Leipzig, Leipzig (Germany); Regenthal, Ralf [University of Leipzig, Division of Clinical Pharmacology, Rudolf Boehm Institute of Pharmacology and Toxicology, Leipzig (Germany); Schinke, Christian [University of Leipzig, Department of Neurology, Leipzig (Germany); Arelin, Katrin [Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Leipzig (Germany); University of Leipzig, Day Clinic for Cognitive Neurology, Leipzig (Germany); Lobsien, Donald [University of Leipzig, Department of Neuroradiology, Leipzig (Germany); Fasshauer, Mathias; Fenske, Wiebke K.; Stumvoll, Michael [Integrated Research and Treatment Centre Adiposity Diseases Leipzig, Leipzig (Germany); University of Leipzig, Medical Department III, Leipzig (Germany); Blueher, Matthias [University of Leipzig, Medical Department III, Leipzig (Germany); University of Leipzig, Collaborative Research Centre 1052 Obesity Mechanisms, Leipzig (Germany)

    2016-06-15

    The role of the central serotonin (5-hydroxytryptamine, 5-HT) system in feeding has been extensively studied in animals with the 5-HT family of transporters (5-HTT) being identified as key molecules in the regulation of satiety and body weight. Aberrant 5-HT transmission has been implicated in the pathogenesis of human obesity by in vivo positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging techniques. However, results obtained thus far from studies of central 5-HTT availability have been inconsistent, which is thought to be brought about mainly by the low number of individuals with a high body mass index (BMI) previously used. The aim of this study was therefore to assess 5-HTT availability in the brains of highly obese otherwise healthy individuals compared with non-obese healthy controls. We performed PET using the 5-HTT selective radiotracer [{sup 11}C] DASB on 30 highly obese (BMI range between 35 and 55 kg/m{sup 2}) and 15 age- and sex-matched non-obese volunteers (BMI range between 19 and 27 kg/m{sup 2}) in a cross-sectional study design. The 5-HTT binding potential (BP{sub ND}) was used as the outcome parameter. On a group level, there was no significant difference in 5-HTT BP{sub ND} in various cortical and subcortical regions in individuals with the highest BMI compared with non-obese controls, while statistical models showed minor effects of age, sex, and the degree of depression on 5-HTT BP{sub ND}. The overall finding of a lack of significantly altered 5-HTT availability together with its high variance in obese individuals justifies the investigation of individual behavioral responses to external and internal cues which may further define distinct phenotypes and subgroups in human obesity. (orig.)

  6. Quality Control of Biomedicinal Allergen Products - Highly Complex Isoallergen Composition Challenges Standard MS Database Search and Requires Manual Data Analyses.

    Directory of Open Access Journals (Sweden)

    Jelena Spiric

    Full Text Available Allergy against birch pollen is among the most common causes of spring pollinosis in Europe and is diagnosed and treated using extracts from natural sources. Quality control is crucial for safe and effective diagnosis and treatment. However, current methods are very difficult to standardize and do not address individual allergen or isoallergen composition. MS provides information regarding selected proteins or the entire proteome and could overcome the aforementioned limitations. We studied the proteome of birch pollen, focusing on allergens and isoallergens, to clarify which of the 93 published sequence variants of the major allergen, Bet v 1, are expressed as proteins within one source material in parallel. The unexpectedly complex Bet v 1 isoallergen composition required manual data interpretation and a specific design of databases, as current database search engines fail to unambiguously assign spectra to highly homologous, partially identical proteins. We identified 47 non-allergenic proteins and all 5 known birch pollen allergens, and unambiguously proved the existence of 18 Bet v 1 isoallergens and variants by manual data analysis. This highly complex isoallergen composition raises questions whether isoallergens can be ignored or must be included for the quality control of allergen products, and which data analysis strategies are to be applied.

  7. Differences in home food availability of high- and low-fat foods after a behavioral weight control program are regional not racial

    Directory of Open Access Journals (Sweden)

    West Delia

    2010-09-01

    Full Text Available Abstract Background Few studies, if any, have examined the impact of a weight control program on the home food environment in a diverse sample of adults. Understanding and changing the availability of certain foods in the home and food storage practices may be important for creating healthier home food environments and supporting effective weight management. Methods Overweight adults (n = 90; 27% African American enrolled in a 6-month behavioral weight loss program in Vermont and Arkansas. Participants were weighed and completed measures of household food availability and food storage practices at baseline and post-treatment. We examined baseline differences and changes in high-fat food availability, low-fat food availability and the storage of foods in easily visible locations, overall and by race (African American or white participants and region (Arkansas or Vermont. Results At post-treatment, the sample as a whole reported storing significantly fewer foods in visible locations around the house (-0.5 ± 2.3 foods, with no significant group differences. Both Arkansas African Americans (-1.8 ± 2.4 foods and Arkansas white participants (-1.8 ± 2.6 foods reported significantly greater reductions in the mean number of high-fat food items available in their homes post-treatment compared to Vermont white participants (-0.5 ± 1.3 foods, likely reflecting fewer high-fat foods reported in Vermont households at baseline. Arkansas African Americans lost significantly less weight (-3.6 ± 4.1 kg than Vermont white participants (-8.3 ± 6.8 kg, while Arkansas white participants did not differ significantly from either group in weight loss (-6.2 ± 6.0 kg. However, home food environment changes were not associated with weight changes in this study. Conclusions Understanding the home food environment and how best to measure it may be useful for both obesity treatment and understanding patterns of obesity prevalence and health disparity.

  8. Emergence of a phase transition for the required amount of storage in highly renewable electricity systems

    DEFF Research Database (Denmark)

    Jensen, Tue Vissing; Greiner, Martin

    2014-01-01

    -up of the required amount of storage, with renewable penetration being the control parameter and average relative storage filling level being the order parameter. A singularity appears for the required storage energy capacity at a renewable penetration determined by the parameters of the storage. For an ideal...

  9. Claudin-1 required for HCV virus entry has high potential for phosphorylation and O-glycosylation.

    Science.gov (United States)

    Ahmad, Waqar; Shabbiri, Khadija; Ijaz, Bushra; Asad, Sultan; Sarwar, Muhammad T; Gull, Sana; Kausar, Humera; Fouzia, Kiran; Shahid, Imran; Hassan, Sajida

    2011-05-15

    HCV is a leading cause of hepatocellular carcinoma and cirrhosis all over the world. Claudins belong to family of tight junction's proteins that are responsible for establishing barriers for controlling the flow of molecules around cells. For therapeutic strategies, regulation of viral entry into the host cells holds a lot of promise. During HCV infection claudin-1 is highly expressed in liver and believed to be associated with HCV virus entry after HCV binding with or without co-receptor CD81. The claudin-1 assembly with tight junctions is regulated by post translational modifications. During claudins assembly and disassembly with tight junctions, phosphorylation is required at C-terminal tail. In cellular proteins, interplay between phosphorylation and O-β-GlcNAc modification is believed to be functional switch, but it is very difficult to monitor these functional and vibrant changes in vivo. Netphos 2.0 and Disphos 1.3 programs were used for potential phosphorylation; NetPhosK 1.0 and KinasePhos for kinase prediction; and YinOYang 1.2 and OGPET to predict possible O-glycosylation sites. We also identified Yin Yang sites that may have potential for O-β-GlcNAc and phosphorylation interplay at same Ser/Thr residues. We for the first time proposed that alternate phosphorylation and O-β-GlcNAc modification on Ser 192, Ser 205, Ser 206; and Thr 191 may provide an on/off switch to regulate assembly of claudin-1 at tight junctions. In addition these phosphorylation sites may be targeted by novel chemotherapeutic agents to prevent phosphorylation lead by HCV viral entry complex.

  10. Neuroimaging of the serotonin reuptake site requires high-affinity ligands.

    Science.gov (United States)

    Elfving, Betina; Madsen, Jacob; Knudsen, Gitte M

    2007-11-01

    Numerous attempts have been made to develop suitable radiolabeled tracers for positron emission tomography or single photon emission computed tomography imaging of the serotonin transporter (SERT), but most often, negative outcomes are reported. The aim of this study is to define characteristics of a good SERT radioligand and to investigate species differences. We examined seven different selective serotonin reuptake inhibitors (SSRIs) and that except for one all have been previously tested as emission tomography ligands. The outcome of the ligands as emission tomography tracers was compared in relation with receptor density (Bmax) and/or ligand affinity (Kd) in rat and monkey cerebrum and cerebellum (reference region) membranes. [3H]-(S)-Citalopram and [3H]-(+)-McN5652 display statistically significantly lower affinity, whereas [3H]paroxetine displays statistically significantly higher affinity for SERT in monkey cortex when compared with the rat cerebrum. The affinity of [3H]MADAM, [123I]ADAM, and [11C]DASB for SERT obtained with rat cerebrum and monkey cortex are similar. In monkey cortex, Kd and Bmax could not be determined with [3H]fluoxetine. Of the seven SSRIs, [3H]-(S)-citalopram, [3H]MADAM, and [11C]DASB displayed significant specific binding to SERT in monkey cerebellum, with Bmax cortex:cerebellum ratios being 17, 3, and 4, respectively. In rat brain tissue the ratios were 12, 6, and 3, respectively. In conclusion, it can be estimated that imaging of the human SERT in a high-density region requires radioligands with Kd values between 0.03 and a maximum of 0.3 nM (at 37 degrees C). The differential specific cerebellar binding raises the question of the suitability of cerebellum as a reference region for nonspecific binding.

  11. High isoproterenol doses are required to activate beta3-adrenoceptor-mediated functions in dogs.

    Science.gov (United States)

    Pelat, Michel; Verwaerde, Patrick; Galitzky, Jean; Lafontan, Max; Berlan, Michel; Senard, Jean-Michel; Montastruc, Jean-Louis

    2003-01-01

    The "in vivo" conditions for beta3-adrenoceptors (beta-AR) activation by isoproterenol were investigated in dog. Experiments were carried out in anesthetized dogs using isoproterenol as a nonselective beta-AR agonist. Intravenous infusion of isoproterenol (0.4 nmol/kg/min) induced arterial hypotension and tachycardia with a slight decrease in cutaneous blood flow. At this dose, isoproterenol increased glucose, glycerol, and nonesterified fatty acid plasma levels. The changes in cardiovascular and endocrine-metabolic parameters, induced by the low dose of isoproterenol, were suppressed by pretreatment with nadolol (1 mg/kg, i.v.). After nadolol administration, however, a 10-fold higher dose (4 nmol/kg/min) of isoproterenol was able to induce a decrease in arterial blood pressure with a slight tachycardia and an increase in cutaneous blood flow. This high dose of isoproterenol increased nonesterified fatty acid and glycerol plasma levels but failed to change glucose plasma levels. All these effects were abolished by a pretreatment with nadolol (1 mg/kg, i.v.) plus SR59230A [a selective beta3-adrenoceptor antagonist; (3-(2-ethylphenoxy)-1(1S)-1,2,3,4-tetrahydronaphth-1-ylaminol-(2S)2-propanol oxalate); 1 mg/kg, i.v.]. Moreover, as observed with the high dose of isoproterenol under nadolol pretreatment, an infusion of SR58611A [a selective beta3-adrenoceptor agonist; ((N2S)-7-carbethoxymethoxy-1,2,3,4-tetrahydronaphth-2-yl-(2R)-2-hydroxy-2-chlorophenyl) ethanamine hydrochloride] induces a decrease in mean arterial blood pressure associated with an increase in heart rate, cutaneous blood flow, and nonesterified fatty acid and glycerol plasma levels. These results demonstrate that the in vivo activation of beta3-adrenoceptors requires higher doses of catecholamine than those necessary for beta1- and/or beta2-adrenoceptor stimulation. These results also argue for the lack of a beta3-AR involvement in the control of heart rate and glycogenolysis in dogs.

  12. Transrectal high-intensity focused ultrasound ablation of prostate cancer: Effective treatment requiring accurate imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rouviere, Olivier [Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France); Universite de Lyon, Lyon F-69003 (France); Universite de Lyon 1, Faculte de Medecine Lyon Nord, Lyon F-69003 (France); INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: Olivier.rouviere@netcourrier.com; Souchon, Remi [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: souchon@lyon.inserm.fr; Salomir, Rares [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: salomir@lyon.inserm.fr; Gelet, Albert [Hospices Civils de Lyon, Department of Urology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France)], E-mail: Albert.gelet@chu-lyon.fr; Chapelon, Jean-Yves [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: chapelon@lyon.inserm.fr; Lyonnet, Denis [Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France); Universite de Lyon, Lyon F-69003 (France); Universite de Lyon 1, Faculte de Medecine Lyon Nord, Lyon F-69003 (France); INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: Denis.lyonnet@chu-lyon.fr

    2007-09-15

    Transrectal HIFU ablation has become a reasonable option for the treatment of localized prostate cancer in non-surgical patients, with 5-year disease-free survival similar to that of radiation therapy. It is also a promising salvage therapy of local recurrence after radiation therapy. These favourable results are partly due to recent improvements in prostate cancer imaging. However, further improvements are needed in patient selection, pre-operative localization of the tumor foci, assessment of the volume treated and early detection of recurrence. A better knowledge of the factors influencing the HIFU-induced tissue destruction and a better pre-operative assessment of them by imaging techniques should improve treatment outcome. Whereas prostate HIFU ablation is currently performed under transrectal ultrasound guidance, MR guidance with real-time operative monitoring of temperature will be available in the near future. If this technique will give better targeting and more uniform tissue destruction, its cost-effectiveness will have to be carefully evaluated. Finally, a recently reported synergistic effect between HIFU ablation and chemotherapy opens possibilities for treatment in high-risk or clinically advanced tumors.

  13. Exigência de fósforo disponível para tilápia-do-nilo (35 a 100 g Available phosphorus requirement of Nile tilapia (35 to 100 g

    Directory of Open Access Journals (Sweden)

    Wilson Massamitu Furuya

    2008-06-01

    Full Text Available Objetivou-se determinar a exigência de fósforo disponível para tilápias-do-nilo. Utilizaram-se 144 peixes com peso vivo inicial de 35,33 ± 0,66 g, distribuídos em delineamento de blocos ao acaso, com quatro tratamentos e três repetições. Foram fornecidas dietas com 29,0% PB, 2.980 kcal/kg de energia digestível (ED e quatro níveis de fósforo disponível (0,25; 0,35; 0,45 ou 0,55%, obtidos pela utilização de fosfato bicálcico como fonte de fósforo. As dietas foram fornecidas aos peixes três vezes por dia, até aparente saciedade, durante 46 dias. Não foi observado efeito dos níveis de fósforo disponível na dieta sobre o índice hepatossomático, a taxa de sobrevivência e os teores de água e proteína bruta na carcaça. O aumento dos níveis de fósforo disponível na dieta promoveu aumento linear do ganho de peso médio, da excreção de fósforo e dos teores de cinza na carcaça e de cinzas, cálcio e fósforo nos ossos. Houve efeito quadrático dos níveis de fósforo disponível sobre o consumo de ração, a conversão alimentar e a taxa de eficiência protéica, que foram melhores nos níveis 0,37; 0,48 e 0,48% de fósforo disponível, respectivamente. A exigência de fósforo disponível para tilápia-do-nilo de 35 a 100 g é de 0,48% (0,53% na matéria seca.The objective of this work was to determine the available phosphorus requirement of Nile tilapia. A total of 144 fishes with initial weight 35.33 ± 0,66g LW were distributed to a completely randomized blocks design, with four treatments and three replicates. Diets with 29.0% CP and 2980 kcal/kg DE and four available phosphorus levels (0.25; 0.35; 0.45 e 0.55% were used. The dicalcium phosphate was used as phosphorus source. The diets were fed to the fishes three times a day to apparent satiation, during 46 days. No significant effect of dietary available phosphorus on hepatosomatic index, survival rate and carcass water and protein contents were observed. The

  14. Review of available power sources

    Energy Technology Data Exchange (ETDEWEB)

    Beard, Carl [CCLRC Daresbury Laboratory, Keckwick Lane, Daresbury, Warrington WA4 4AD (United Kingdom)]. E-mail: c.d.beard@dl.ac.uk

    2006-02-01

    Klystrons and triodes have been the accepted choice for particle accelerators because they produce high power RF and offer high gain (60 dB) with efficiencies of {approx}50%. Although fairly new to the market, inductive output tubes (IOTs) have become available at L-band frequencies and have maintained their high efficiency. The development of superconducting RF at the L-band frequency allows IOTs to become the choice for future accelerator programs. Due to the operational nature of SRF technology in energy recovery mode, there is no longer the requirement for large amounts of RF power from single sources. This report reviews some of the developments in RF power sources suitable for energy recovery linacs (ERLs)

  15. 77 FR 72993 - Atlantic Highly Migratory Species; Electronic Dealer Reporting Requirements; Correction

    Science.gov (United States)

    2012-12-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE... Species; Electronic Dealer Reporting Requirements; Correction AGENCY: National Marine Fisheries Service... final regulations regarding electronic dealer reporting, which published August 8, 2012, with an...

  16. Emergence of a phase transition for the required amount of storage in highly renewable electricity systems

    DEFF Research Database (Denmark)

    Jensen, Tue Vissing; Greiner, Martin

    2014-01-01

    Due to global environmental concerns, our electricity supply will transform from mostly conventional power generation to mostly fluctuating renewable power generation. The transition will require combined backup from conventional sources and storage. A phase transition emerges during the ramp...... storage with no roundtrip losses the transition occurs at 100% renewable penetration. Moreover, the required storage energy capacity is strongly enhanced by temporal correlations on the synoptic weather time scale. A Markov process is proposed, which reproduces these findings....

  17. The physiological response of two green calcifying algae from the Great Barrier Reef towards high dissolved inorganic and organic carbon (DIC and DOC availability.

    Directory of Open Access Journals (Sweden)

    Friedrich Wilhelm Meyer

    Full Text Available Increasing dissolved inorganic carbon (DIC concentrations associated with ocean acidification can affect marine calcifiers, but local factors, such as high dissolved organic carbon (DOC concentrations through sewage and algal blooms, may interact with this global factor. For calcifying green algae of the genus Halimeda, a key tropical carbonate producer that often occurs in coral reefs, no studies on these interactions have been reported. These data are however urgently needed to understand future carbonate production. Thus, we investigated the independent and combined effects of DIC (pCO2 402 μatm/ pHtot 8.0 and 996 μatm/ pHtot 7.7 and DOC (added as glucose in 0 and 294 μmol L-1 on growth, calcification and photosynthesis of H. macroloba and H. opuntia from the Great Barrier Reef in an incubation experiment over 16 days. High DIC concentrations significantly reduced dark calcification of H. opuntia by 130 % and led to net dissolution, but did not affect H. macroloba. High DOC concentrations significantly reduced daily oxygen production of H. opuntia and H. macroloba by 78 % and 43 %, respectively, and significantly reduced dark calcification of H. opuntia by 70%. Combined high DIC and DOC did not show any interactive effects for both algae, but revealed additive effects for H. opuntia where the combination of both factors reduced dark calcification by 162 % compared to controls. Such species-specific differences in treatment responses indicate H. opuntia is more susceptible to a combination of high DIC and DOC than H. macroloba. From an ecological perspective, results further suggest a reduction of primary production for Halimeda-dominated benthic reef communities under high DOC concentrations and additional decreases of carbonate accretion under elevated DIC concentrations, where H. opuntia dominates the benthic community. This may reduce biogenic carbonate sedimentation rates and hence the buffering capacity against further ocean

  18. Research requirements for a real-time flight measurements and data analysis system for subsonic transport high-lift research

    Science.gov (United States)

    Whitehead, Julia H.; Harris, Franklin K.; Lytle, Carroll D.

    1993-01-01

    A multiphased research program to obtain detailed flow characteristics on a multielement high-lift flap system is being conducted on the Transport Systems Research Vehicle (B737-100 aircraft) at NASA Langley Research Center. Upcoming flight tests have required the development of a highly capable and flexible flight measurement and data analysis instrumentation system. This instrumentation system will be more comprehensive than any of the systems used on previous high-lift flight experiment at NASA Langley. The system will provide the researcher near-real-time information for decision making needed to modify a flight test in order to further examine unexpected flow conditions. This paper presents the research requirements and instrumentation design concept for an upcoming flight experiment for the subsonic transport high-lift research program. The flight experiment objectives, the measurement requirements, the data acquisition system, and the onboard data analysis and display capabilities are described.

  19. Effect of phytase application during high gravity (HG) maize mashes preparation on the availability of starch and yield of the ethanol fermentation process.

    Science.gov (United States)

    Mikulski, D; Kłosowski, G; Rolbiecka, A

    2014-10-01

    Phytic acid present in raw materials used in distilling industry can form complexes with starch and divalent cations and thus limit their biological availability. The influence of the enzymatic hydrolysis of phytate complexes on starch availability during the alcoholic fermentation process using high gravity (HG) maize mashes was analyzed. Indicators of the alcoholic fermentation as well as the fermentation activity of Saccharomyces cerevisiae D-2 strain were statistically evaluated. Phytate hydrolysis improved the course of the alcoholic fermentation of HG maize mashes. The final ethanol concentration in the media supplemented with phytase applied either before or after the starch hydrolysis increased by 1.0 and 0.6 % v/v, respectively, as compared to the control experiments. This increase was correlated with an elevated fermentation yield that was higher by 5.5 and 2.0 L EtOH/100 kg of starch, respectively. Phytate hydrolysis resulted also in a statistically significant increase in the initial concentration of fermenting sugars by 14.9 mg/mL of mash, on average, which was a consequence of a better availability of starch for enzymatic hydrolysis. The application of phytase increased the attenuation of HG media fermentation thus improving the economical aspect of the ethanol fermentation process.

  20. Biochar from sugarcane filtercake reduces soil CO2 emissions relative to raw residue and improves water retention and nutrient availability in a highly-weathered tropical soil.

    Directory of Open Access Journals (Sweden)

    Angela Joy Eykelbosh

    Full Text Available In Brazil, the degradation of nutrient-poor Ferralsols limits productivity and drives agricultural expansion into pristine areas. However, returning agricultural residues to the soil in a stabilized form may offer opportunities for maintaining or improving soil quality, even under conditions that typically promote carbon loss. We examined the use of biochar made from filtercake (a byproduct of sugarcane processing on the physicochemical properties of a cultivated tropical soil. Filtercake was pyrolyzed at 575°C for 3 h yielding a biochar with increased surface area and porosity compared to the raw filtercake. Filtercake biochar was primarily composed of aromatic carbon, with some residual cellulose and hemicellulose. In a three-week laboratory incubation, CO2 effluxes from a highly weathered Ferralsol soil amended with 5% biochar (dry weight, d.w. were roughly four-fold higher than the soil-only control, but 23-fold lower than CO2 effluxes from soil amended with 5% (d.w. raw filtercake. We also applied vinasse, a carbon-rich liquid waste from bioethanol production typically utilized as a fertilizer on sugarcane soils, to filtercake- and biochar-amended soils. Total CO2 efflux from the biochar-amended soil in response to vinasse application was only 5% of the efflux when vinasse was applied to soil amended with raw filtercake. Furthermore, mixtures of 5 or 10% biochar (d.w. in this highly weathered tropical soil significantly increased water retention within the plant-available range and also improved nutrient availability. Accordingly, application of sugarcane filtercake as biochar, with or without vinasse application, may better satisfy soil management objectives than filtercake applied to soils in its raw form, and may help to build soil carbon stocks in sugarcane-cultivating regions.

  1. Niche shifts and energetic condition of songbirds in response to phenology of food-resource availability in a high-elevation sagebrush ecosystem

    Science.gov (United States)

    Cutting, Kyle A.; Anderson, Michelle L.; Beever, Erik; Schroff, Sean; Korb, Nathan; Klaphake, Eric; McWilliams, Scott R.

    2016-01-01

    Seasonal fluctuations in food availability can affect diets of consumers, which in turn may influence the physiological state of individuals and shape intra- and inter-specific patterns of resource use. High-elevation ecosystems often exhibit a pronounced seasonal “pulse” in productivity, although few studies document how resource use and energetic condition by avian consumers change in relation to food-resource availability in these ecosystems. We tested the hypothesis that seasonal increases (pulses) in food resources in high-elevation sagebrush ecosystems result in 2 changes after the pulse, relative to the before-pulse period: (1) reduced diet breadth of, and overlap between, 2 sympatric sparrow species; and (2) enhanced energetic condition in both species. We tracked breeding-season diets using stable isotopes and energetic condition using plasma metabolites of Brewer's Sparrows (Spizella breweri), Vesper Sparrows (Pooecetes gramineus), and their food resources during 2011, and of only Brewer's Sparrows and their food resources during 2013. We quantify diet breadth and overlap between both species, along with coincident physiological consequences of temporal changes in resource use. After invertebrate biomass increased following periods of rainfall in 2011, dietary breadth decreased by 35% in Brewer's Sparrows and by 48% in Vesper Sparrows, while dietary overlap decreased by 88%. Energetic condition of both species increased when dietary overlap was lower and diet breadth decreased, after the rapid rise of food-resource availability. However, energetic condition of Brewer's Sparrows remained constant in 2013, a year with low precipitation and lack of a strong pulse in food resources, even though the species' dietary breadth again decreased that year. Our results indicate that diet breadth and overlap in these sparrow species inhabiting sagebrush ecosystems generally varied as predicted in relation to intra- and interannual changes in food resources, and

  2. Gamma-ray, neutron, and hard X-ray studies and requirements for a high-energy solar physics facility

    Science.gov (United States)

    Ramaty, R.; Dennis, B. R.; Emslie, A. G.

    1988-01-01

    The requirements for future high-resolution spatial, spectral, and temporal observation of hard X-rays, gamma rays and neutrons from solar flares are discussed in the context of current high-energy flare observations. There is much promise from these observations for achieving a deep understanding of processes of energy release, particle acceleration and particle transport in a complicated environment such as the turbulent and highly magnetized atmosphere of the active sun.

  3. Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development.

    Science.gov (United States)

    Provost, Elayne; Weier, Christopher A; Leach, Steven D

    2013-06-01

    Ribosomal protein L (rpl) genes are essential for assembly of the 60S subunit of the eukaryotic ribosome and may also carry out additional extra-ribosomal functions. We have identified a common expression pattern for rpl genes in developing zebrafish larvae. After initially widespread expression in early embryos, the expression of multiple rpl genes becomes increasingly restricted to the endoderm. With respect to the pancreas, rpl genes are highly expressed in ptf1a-expressing pancreatic progenitors at 48 hpf, suggesting possible functional roles in pancreatic morphogenesis and/or differentiation. Utilizing two available mutant lines, rpl23a(hi2582) and rpl6(hi3655b), we found that ptf1a-expressing pancreatic progenitors fail to properly expand in embryos homozygous for either of these genes. In addition to these durable homozygous phenotypes, we also demonstrated recoverable delays in ptf1a-expressing pancreatic progenitor expansion in rpl23a(hi2582) and rpl6(hi3655b) heterozygotes. Disruptions in ribosome assembly are generally understood to initiate a p53-dependent cellular stress response. However, concomitant p53 knockdown was unable to rescue normal pancreatic progenitor expansion in either rpl23a(hi2582) or rpl6(hi3655b) mutant embryos, suggesting required and p53-independent roles for rpl23a and rpl6 in pancreas development.

  4. Cubilin, a High Affinity Receptor for Fibroblast Growth Factor 8, Is Required for Cell Survival in the Developing Vertebrate Head*

    Science.gov (United States)

    Cases, Olivier; Perea-Gomez, Aitana; Aguiar, Diego P.; Nykjaer, Anders; Amsellem, Sabine; Chandellier, Jacqueline; Umbhauer, Muriel; Cereghini, Silvia; Madsen, Mette; Collignon, Jérôme; Verroust, Pierre; Riou, Jean-François; Creuzet, Sophie E.; Kozyraki, Renata

    2013-01-01

    Cubilin (Cubn) is a multiligand endocytic receptor critical for the intestinal absorption of vitamin B12 and renal protein reabsorption. During mouse development, Cubn is expressed in both embryonic and extra-embryonic tissues, and Cubn gene inactivation results in early embryo lethality most likely due to the impairment of the function of extra-embryonic Cubn. Here, we focus on the developmental role of Cubn expressed in the embryonic head. We report that Cubn is a novel, interspecies-conserved Fgf receptor. Epiblast-specific inactivation of Cubn in the mouse embryo as well as Cubn silencing in the anterior head of frog or the cephalic neural crest of chick embryos show that Cubn is required during early somite stages to convey survival signals in the developing vertebrate head. Surface plasmon resonance analysis reveals that fibroblast growth factor 8 (Fgf8), a key mediator of cell survival, migration, proliferation, and patterning in the developing head, is a high affinity ligand for Cubn. Cell uptake studies show that binding to Cubn is necessary for the phosphorylation of the Fgf signaling mediators MAPK and Smad1. Although Cubn may not form stable ternary complexes with Fgf receptors (FgfRs), it acts together with and/or is necessary for optimal FgfR activity. We propose that plasma membrane binding of Fgf8, and most likely of the Fgf8 family members Fgf17 and Fgf18, to Cubn improves Fgf ligand endocytosis and availability to FgfRs, thus modulating Fgf signaling activity. PMID:23592779

  5. Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.

    Science.gov (United States)

    Cases, Olivier; Perea-Gomez, Aitana; Aguiar, Diego P; Nykjaer, Anders; Amsellem, Sabine; Chandellier, Jacqueline; Umbhauer, Muriel; Cereghini, Silvia; Madsen, Mette; Collignon, Jérôme; Verroust, Pierre; Riou, Jean-François; Creuzet, Sophie E; Kozyraki, Renata

    2013-06-07

    Cubilin (Cubn) is a multiligand endocytic receptor critical for the intestinal absorption of vitamin B12 and renal protein reabsorption. During mouse development, Cubn is expressed in both embryonic and extra-embryonic tissues, and Cubn gene inactivation results in early embryo lethality most likely due to the impairment of the function of extra-embryonic Cubn. Here, we focus on the developmental role of Cubn expressed in the embryonic head. We report that Cubn is a novel, interspecies-conserved Fgf receptor. Epiblast-specific inactivation of Cubn in the mouse embryo as well as Cubn silencing in the anterior head of frog or the cephalic neural crest of chick embryos show that Cubn is required during early somite stages to convey survival signals in the developing vertebrate head. Surface plasmon resonance analysis reveals that fibroblast growth factor 8 (Fgf8), a key mediator of cell survival, migration, proliferation, and patterning in the developing head, is a high affinity ligand for Cubn. Cell uptake studies show that binding to Cubn is necessary for the phosphorylation of the Fgf signaling mediators MAPK and Smad1. Although Cubn may not form stable ternary complexes with Fgf receptors (FgfRs), it acts together with and/or is necessary for optimal FgfR activity. We propose that plasma membrane binding of Fgf8, and most likely of the Fgf8 family members Fgf17 and Fgf18, to Cubn improves Fgf ligand endocytosis and availability to FgfRs, thus modulating Fgf signaling activity.

  6. Long-term high-temperature and pH stability assessment of modern commercially available stationary phases by using retention factor analysis.

    Science.gov (United States)

    Haun, Jakob; Oeste, Katja; Teutenberg, Thorsten; Schmidt, Torsten C

    2012-11-09

    High-temperature liquid chromatography provides several advantages concerning HPLC method development and is needed to realize special hyphenation techniques. However, hardware limitations and stationary phase degradation can prevent the successful application of this technique. Therefore, column stability is of major importance. The presented study contains results of long-term high-temperature stability tests for eight modern commercially available HPLC stationary phases. Six of them were silica-based reversed-phase C18 columns tested according to an earlier reported procedure (Teutenberg, 2009 [12]). On the basis of the extended data set that covers a wide range of column technologies, a comparative approach using retention factor analysis was evaluated in order to categorize the columns according to their long-term high-temperature stability at 150 °C and changing pH value. This approach offers a more objective alternative to conventional listings in which temperature maxima are compared for columns tested under different conditions. Additionally, customized tests are presented for one promising polymer-based C18 stationary phase and an amide column for hydrophilic interaction liquid chromatography.

  7. Numerical investigation of power requirements for ultra-high-speed serial-to-parallel conversion

    DEFF Research Database (Denmark)

    Lillieholm, Mads; Mulvad, Hans Christian Hansen; Palushani, Evarist

    2012-01-01

    We present a numerical bit-error rate investigation of 160-640 Gbit/s serial-to-parallel conversion by four-wave mixing based time-domain optical Fourier transformation, showing an inverse scaling of the required pump energy per bit with the bit rate.......We present a numerical bit-error rate investigation of 160-640 Gbit/s serial-to-parallel conversion by four-wave mixing based time-domain optical Fourier transformation, showing an inverse scaling of the required pump energy per bit with the bit rate....

  8. 40 CFR 799.5085 - Chemical testing requirements for certain high production volume chemicals.

    Science.gov (United States)

    2010-07-01

    ... (preferred species), rat, or Chinese hamster): 40 CFR 799.9538 OR Mammalian Erythrocyte Micronucleus Test (in... CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS Multichemical Test Rules § 799.5085 Chemical testing... paragraph (j) of this section at any time from April 17, 2006 to the end of the test data...

  9. Synapsin Is Required to "Boost" Memory Strength for Highly Salient Events

    Science.gov (United States)

    Kleber, Jörg; Chen, Yi-Chun; Michels, Birgit; Saumweber, Timo; Schleyer, Michael; Kähne, Thilo; Buchner, Erich; Gerber, Bertram

    2016-01-01

    Synapsin is an evolutionarily conserved presynaptic phosphoprotein. It is encoded by only one gene in the "Drosophila" genome and is expressed throughout the nervous system. It regulates the balance between reserve and releasable vesicles, is required to maintain transmission upon heavy demand, and is essential for proper memory function…

  10. Biochar from Sugarcane Filtercake Reduces Soil CO2 Emissions Relative to Raw Residue and Improves Water Retention and Nutrient Availability in a Highly-Weathered Tropical Soil

    Science.gov (United States)

    Eykelbosh, Angela Joy; Johnson, Mark S.; Santos de Queiroz, Edmar; Dalmagro, Higo José; Guimarães Couto, Eduardo

    2014-01-01

    In Brazil, the degradation of nutrient-poor Ferralsols limits productivity and drives agricultural expansion into pristine areas. However, returning agricultural residues to the soil in a stabilized form may offer opportunities for maintaining or improving soil quality, even under conditions that typically promote carbon loss. We examined the use of biochar made from filtercake (a byproduct of sugarcane processing) on the physicochemical properties of a cultivated tropical soil. Filtercake was pyrolyzed at 575°C for 3 h yielding a biochar with increased surface area and porosity compared to the raw filtercake. Filtercake biochar was primarily composed of aromatic carbon, with some residual cellulose and hemicellulose. In a three-week laboratory incubation, CO2 effluxes from a highly weathered Ferralsol soil amended with 5% biochar (dry weight, d.w.) were roughly four-fold higher than the soil-only control, but 23-fold lower than CO2 effluxes from soil amended with 5% (d.w.) raw filtercake. We also applied vinasse, a carbon-rich liquid waste from bioethanol production typically utilized as a fertilizer on sugarcane soils, to filtercake- and biochar-amended soils. Total CO2 efflux from the biochar-amended soil in response to vinasse application was only 5% of the efflux when vinasse was applied to soil amended with raw filtercake. Furthermore, mixtures of 5 or 10% biochar (d.w.) in this highly weathered tropical soil significantly increased water retention within the plant-available range and also improved nutrient availability. Accordingly, application of sugarcane filtercake as biochar, with or without vinasse application, may better satisfy soil management objectives than filtercake applied to soils in its raw form, and may help to build soil carbon stocks in sugarcane-cultivating regions. PMID:24897522

  11. How Integrated Management Strategies Promote Protein Quality of Cotton Embryos: High Levels of Soil Available N, N Assimilation and Protein Accumulation Rate.

    Science.gov (United States)

    Yang, HongKun; Meng, YaLi; Chen, BingLin; Zhang, XingYue; Wang, YouHua; Zhao, WenQing; Zhou, ZhiGuo

    2016-01-01

    Cottonseed is widely used as a source of ruminant feed and for industrial purposes. Therefore, there is a tremendous need to improve the nutritional value of cotton embryos. In this study, a conventional management (CM) and two integrated cotton management strategies (IMS1, IMS2) were performed at two soil fertility levels to study the relationships among soil N, N assimilation, embryonic protein accumulation and protein quality. The levels of proteins, essential amino acids, and semi-essential amino acids, especially those of glutamate, lysine, and methionine, were higher in IMS1 and IMS2 embryos than in CM embryos. These changes were significantly positively correlated with the soil-available N content, glutamine synthetase activity and peak value of protein accumulation rate and were negatively correlated with the free amino acid level. These results illustrated that integrated management strategies, especially the rates and timing of N application, raise the level of soil available N, which is beneficial for N assimilation in developing cotton embryos. The protein content was limited by the rate of protein accumulation rather than by the free amino acid content. The combination of target yield fertilization, a growth-driven N application schedule, a high plant density and the seedling raising with bio-organic fertilizer can substantially improve protein quality in cotton embryos, especially at a soil with low soil organic matter and total nitrogen.

  12. Required water quality for the use of high-performance membranes.

    Science.gov (United States)

    Aoike, Ikuo

    2011-01-01

    The clinical benefits of high-performance membrane (HPM) dialyzers have often been reported since the advent of the synthetic polyacrylonitrile dialysis membrane. HPMs, which have high water permeability, eliminate a wide spectrum of uremic toxins, and offer excellent biocompatibility, are now essential for hemodialysis, hemofiltration, and hemodiafiltration. For HPMs whose mean pore size is enlarged to secure better dialysis membrane performance, however, the dialyzing fluid must be highly purified to prevent contamination. Blood purification therapies using highly purified dialyzing fluid and HPM are expected to improve the prognosis of future patients undergoing dialysis. Copyright © 2011 S. Karger AG, Basel.

  13. High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-1C]pyruvate magnetic resonance imaging

    DEFF Research Database (Denmark)

    Laustsen, Christoffer; Lycke, Sara; Palm, Fredrik;

    2014-01-01

    The kidneys account for about 10% of the whole body oxygen consumption, whereas only 0.5% of the total body mass. It is known that intrarenal hypoxia is present in several diseases associated with development of kidney disease, including diabetes, and when renal blood flow is unaffected. The impo...... of nephropathy in patients with diabetes at high altitudes may originate from the increased sensitivity toward inspired oxygen. This increased lactate production shifts the metabolic routs toward hypoxic pathways.......The kidneys account for about 10% of the whole body oxygen consumption, whereas only 0.5% of the total body mass. It is known that intrarenal hypoxia is present in several diseases associated with development of kidney disease, including diabetes, and when renal blood flow is unaffected....... The importance of deranged oxygen metabolism is further supported by deterioration of kidney function in patients with diabetes living at high altitude. Thus, we argue that reduced oxygen availability alters renal energy metabolism. Here, we introduce a novel magnetic resonance imaging (MRI) approach to monitor...

  14. How valid are commercially available medical simulators?

    NARCIS (Netherlands)

    Stunt, J.J.; Wulms, P.H.; Kerkhoffs, G.M.; Dankelman, J.; Van Dijk, C.N.; Tuijthof, G.J.M.

    2014-01-01

    Background: Since simulators offer important advantages, they are increasingly used in medical education and medical skills training that require physical actions. A wide variety of simulators have become commercially available. It is of high importance that evidence is provided that training on the

  15. Computing requirements for high energy physics experiments at the LHC collider

    CERN Document Server

    Witek, Mariusz

    2002-01-01

    In this article the requirements for the future experiments of elementary particle physics are discussed. The nature of physics phenomena expected at the LHC collider at CERN leads to an unprecedented scale of the computing infrastructure for the data storage and analysis. The possible solution is based on the distributed computing model, and is presented within the context of the global unification of the computer resources as proposed by the GRID projects. (7 refs).

  16. An Arabidopsis thaliana high-affinity molybdate transporter required for efficient uptake of molybdate from soil

    OpenAIRE

    Tomatsu, Hajime; Takano, Junpei; Takahashi, Hideki; Watanabe-Takahashi, Akiko; Shibagaki, Nakako; Fujiwara, Toru

    2007-01-01

    Molybdenum (Mo) is a trace element essential for living organisms, however no molybdate transporter has been identified in eukaryotes. Here, we report the identification of a molybdate transporter, MOT1, from Arabidopsis thaliana. MOT1 is expressed in both roots and shoots, and the MOT1 protein is localized, in part, to plasma membranes and to vesicles. MOT1 is required for efficient uptake and translocation of molybdate and for normal growth under conditions of limited molybdate supply. Kine...

  17. Research on TCP High Availability Technology for Embedded Network Device%嵌入式网络设备TCP高可用技术研究

    Institute of Scientific and Technical Information of China (English)

    程友清; 余少华

    2013-01-01

    This paper focus on research of TCP high availability technology for embedded double controller network device or virtual cluster switch system in data communication network. It puts forward a new TCP high availability scheme, which only makes a small amount of modification of the TCP/IP protocol stack and upper layer TCP applications. The master synchronizes TCP connection information to slave only when the TCP connection was established or closed, the TCP/IP protocol stack in slave card or device uses the received TCP synchronization information to create or close the TCP socket and store the TCP connection information into TCP control block (TCPCB), then inform the TCP socket information to upper layer TCP applications to handle. When master crashes for some reason, the slave will change to master immediately, the synchronized TCP connection on the new master initializes its TCP control block information, such as send packet sequence number and receive packet sequence number, when receives the first TCP packet of the TCP socket. After that the TCP connection has been switched successfully, the upper layer TCP applications then send or receive packet as a normal TCP connection. The scheme described above has been used in practice on high-end Ethernet switch and router developed by the author's team, the test results and practical application show that the TCP high availability scheme consumed a small a-mount of communication bandwidth to synchronize the TCP connection information from master to slave and achieved microsecond level switchover of TCP connection when master card or device going down.%对数据网络中嵌入式双主控设备和虚拟集群交换系统的TCP高可用技术进行了研究.提出一种新的TCP高可用方案,该方案对TCP/IP协议栈和TCP应用软件做少量改动.主用设备只需在TCP连接建立或关闭时向备用发送TCP连接同步信息,备用设备上TCP/IP栈收到同步信息后强制创建或关闭TCP套接字并

  18. Relationship between High School Mathematics Grade and Number of Attempts Required to Pass the Medication Calculation Test in Nurse Education: An Explorative Study

    Directory of Open Access Journals (Sweden)

    Johanne Alteren

    2015-05-01

    Full Text Available In Norwegian nurse education, students are required to achieve a perfect score in a medication calculation test before undertaking their first practice period during the second semester. Passing the test is a challenge, and students often require several attempts. Adverse events in medication administration can be related to poor mathematical skills. The purpose of this study was to explore the relationship between high school mathematics grade and the number of attempts required to pass the medication calculation test in nurse education. The study used an exploratory design. The participants were 90 students enrolled in a bachelor’s nursing program. They completed a self-report questionnaire, and statistical analysis was performed. The results provided no basis for the conclusion that a statistical relationship existed between high school mathematics grade and number of attempts required to pass the medication calculation test. Regardless of their grades in mathematics, 43% of the students passed the medication calculation test on the first attempt. All of the students who had achieved grade 5 had passed by the third attempt. High grades in mathematics were not crucial to passing the medication calculation test. Nonetheless, the grade may be important in ensuring a pass within fewer attempts.

  19. The High Affinity Iron Permease is a Key Virulence Factor Required for Rhizopus oryzae Pathogenesis

    Science.gov (United States)

    Rhizopus oryzae is the most common cause of mucormycosis, an angioinvasive fungal infection that causes a >/=50% mortality rate despite first-line therapy. Clinical and animal model data clearly demonstrate that the presence of elevated available serum iron predisposes the host to mucormycosis. Th...

  20. Educating Faculty Members on the Importance of Requiring High-Quality Information Resources at a Community College

    Science.gov (United States)

    Auten, Beth; Glauner, Dana; Lefoe, Grant; Henry, Jo

    2016-01-01

    This article explains how the South Piedmont Community College librarians educated faculty members about how they guide student use of the library and how it is advantageous for them to require high-quality resources for student papers. As documented by observations at SPCC and in the library literature, students use the tools they know to find…

  1. Scavenger Receptor BI-mediated Selective Uptake Is Required for the Remodeling of High Density Lipoprotein by Endothelial Lipase

    NARCIS (Netherlands)

    Nijstad, Niels; Wiersma, Harmen; Gautier, Thomas; van der Giet, Markus; Maugeais, Cyrille; Tietge, Uwe J. F.

    2009-01-01

    Endothelial lipase (EL) is a negative regulator of high density lipoprotein (HDL) cholesterol plasma levels, and scavenger receptor BI (SR-BI) is involved in remodeling of HDL. The present study investigates the requirement of SR-BI for the effects of EL- mediated phospholipid hydrolysis on HDL meta

  2. Elevating Instruction for Secondary-School Students with Learning Disabilities by Demystifying the Highly Qualified Subject Matter Requirement

    Science.gov (United States)

    McKenzie, Robert G.

    2009-01-01

    The highly qualified mandate of the No Child Left Behind Act and Individuals with Disabilities Education Act has created unnecessary confusion, particularly among secondary-school special educators and administrators with respect to instruction in core academic subjects. The pursuit of compliance solutions to meet this requirement has generally…

  3. Educating Faculty Members on the Importance of Requiring High-Quality Information Resources at a Community College

    Science.gov (United States)

    Auten, Beth; Glauner, Dana; Lefoe, Grant; Henry, Jo

    2016-01-01

    This article explains how the South Piedmont Community College librarians educated faculty members about how they guide student use of the library and how it is advantageous for them to require high-quality resources for student papers. As documented by observations at SPCC and in the library literature, students use the tools they know to find…

  4. Phagocytosis of IgG‐Coated Polystyrene Beads by Macrophages Induces and Requires High Membrane Order

    National Research Council Canada - National Science Library

    Magenau, Astrid; Benzing, Carola; Proschogo, Nicholas; Don, Anthony S; Hejazi, Leila; Karunakaran, Denuja; Jessup, Wendy; Gaus, Katharina

    2011-01-01

    ...)‐coated polystyrene particles. We found that the plasma membrane undergoes rapid actin‐independent condensation to form highly ordered phagosomal membranes, the biophysical hallmark of lipid rafts...

  5. High Performance Computing and Storage Requirements for Biological and Environmental Research Target 2017

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, Richard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC); Wasserman, Harvey [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)

    2013-05-01

    The National Energy Research Scientific Computing Center (NERSC) is the primary computing center for the DOE Office of Science, serving approximately 4,500 users working on some 650 projects that involve nearly 600 codes in a wide variety of scientific disciplines. In addition to large-­scale computing and storage resources NERSC provides support and expertise that help scientists make efficient use of its systems. The latest review revealed several key requirements, in addition to achieving its goal of characterizing BER computing and storage needs.

  6. Extreme Multiplex Spectrograph: An efficient mechanical design for high-demanding requirements

    CERN Document Server

    Becerril, S; Dubbeldam, C M; Content, R; Rohloff, R R; Prada, F; Shanks, T; Sharples, R

    2010-01-01

    XMS is a multi-channel wide-field spectrograph designed for the prime focus of the 3.5m Calar-Alto telescope. The instrument is composed by four quadrants, each of which contains a spectrograph channel. An innovative mechanical design -at concept/preliminary stage- has been implemented to: 1) Minimize the separation between the channels to achieve maximal filling factor; 2) Cope with the very constraining space and mass overall requirements; 3) Achieve very tight alignment tolerances; 4) Provide lens self-centering under large temperature excursions; 5) Provide masks including 4000 slits (edges thinner than 100\\mu). An overview of this extremely challenging mechanical design is here presented.

  7. Life design of high-temperature turbine blades with minimum cooling requirements

    Science.gov (United States)

    Nagoga, G. P.; Tseitlin, V. I.; Balter, V. P.

    The problem of minimizing fuel requirements for the air cooling of gas turbine blades, while providing for a specified service life, is stated and solved for a dual-mode engine. It is shown that, for a multimode engine, the problem should be solved by using nonlinear programming methods. It is further shown that fuel consumption for blade cooling can be minimized only by controlling air flow rate with allowance for the operation mode. Recommendations concerning practical applications of the results of the study are given.

  8. Availability of a remote online hemodynamic monitoring system during treatment in a private dental office for medically high-risk patients

    Directory of Open Access Journals (Sweden)

    Shinya Yamazaki

    2008-09-01

    Full Text Available Shinya Yamazaki, Hiroyoshi Kawaai, Shigeo Sasaki, Kazuhiro Shimamura, Hiroshi Segawa, Takahiro SaitoSpecial Care Department in Dentistry, Ohu University Dental Hospital, Koriyama city, Fukushima prefecture, JapanAbstract: The importance of systemic management to prevent accidents is increasing in dentistry because co-morbid illnesses in an aging society and invasive surgical procedures are increasing. In this prefecture, a new medical system called the remote online hemodynamic monitoring system (ROHMs was started in 2001. Eight private dental offices participated in this trial. When dental practitioners feel the risk of a dental procedure, they can contact via ROHMs to this hospital. Then, the hemodynamic data (blood pressure, heart rate, ECG, SpO2, and RPP of the patient in the clinic can be transmitted here via the internet, and the images and the voice can be transmitted as well. The availability of this system was assessed in 66 patients (98 cases. The most frequent complications were hypertension, heart disease, and diabetes mellitus. Systemic management included monitoring during the dental procedure (71.4%, checking vital signs after an interview (15.3%, and monitoring under sedation (13.3%. There were 35.7% of all cases where an unscheduled procedure was necessary for the systemic management. Based on a questionnaire, the majority of the patients felt relieved and safe. This system creates a situation where a specialist is almost present during the procedure. This system will provide significant assistance for future medical cooperation for risk management.Keywords: online, high-risk patient, dental treatment, medical cooperation, medical accident, risk management

  9. Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

    Directory of Open Access Journals (Sweden)

    Meuwissen Pieter J

    2012-04-01

    Full Text Available Abstract Background The Nef protein of HIV facilitates virus replication and disease progression in infected patients. This role as pathogenesis factor depends on several genetically separable Nef functions that are mediated by interactions of highly conserved protein-protein interaction motifs with different host cell proteins. By studying the functionality of a series of nef alleles from clinical isolates, we identified a dysfunctional HIV group O Nef in which a highly conserved valine-glycine-phenylalanine (VGF region, which links a preceding acidic cluster with the following proline-rich motif into an amphipathic surface was deleted. In this study, we aimed to study the functional importance of this VGF region. Results The dysfunctional HIV group O8 nef allele was restored to the consensus sequence, and mutants of canonical (NL4.3, NA-7, SF2 and non-canonical (B2 and C1422 HIV-1 group M nef alleles were generated in which the amino acids of the VGF region were changed into alanines (VGF→AAA and tested for their capacity to interfere with surface receptor trafficking, signal transduction and enhancement of viral replication and infectivity. We found the VGF motif, and each individual amino acid of this motif, to be critical for downregulation of MHC-I and CXCR4. Moreover, Nef’s association with the cellular p21-activated kinase 2 (PAK2, the resulting deregulation of cofilin and inhibition of host cell actin remodeling, and targeting of Lck kinase to the trans-golgi-network (TGN were affected as well. Of particular interest, VGF integrity was essential for Nef-mediated enhancement of HIV virion infectivity and HIV replication in peripheral blood lymphocytes. For targeting of Lck kinase to the TGN and viral infectivity, especially the phenylalanine of the triplet was essential. At the molecular level, the VGF motif was required for the physical interaction of the adjacent proline-rich motif with Hck. Conclusion Based on these findings, we

  10. Review of important rock mechanics studies required for underground high level nuclear waste repository program

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, S.; Cho, W. J

    2007-01-15

    Disposal concept adapting room and pillar method, which is a confirmed technique in mining and tunnel construction for long time, has advantages at cost, safety, technical feasibility, flexibility, and international cooperation point of views. Then the important rock mechanics principals and in situ and laboratory tests for understanding the behavior of rock, buffer, and backfill as well as their interactions will be reviewed. The accurate understanding of them is important for developing a safe disposal concept and successful operation of underground repository for permanent disposal of radioactive wastes. First of all, In this study, current status of rock mechanics studies for HLW disposal in foreign countries such as Sweden, USA, Canada, Finland, Japan, and France were reviewed. After then the in situ and laboratory tests for site characterization were summarized. Furthermore, rock mechanics studies required during the whole procedure for the disposal project from repository design to the final closure will be reviewed systematically. This study will help for developing a disposal system including site selection, repository design, operation, maintenance, and closure of a repository in deep underground rock. By introducing the required rock mechanics tests at different stages, it would be helpful from the planning stage to the operation stage of a radioactive waste disposal project.

  11. Towards a robust evaporation-based disaggregation method of SMOS soil moisture by combining high-resolution shortwave/thermal and available meteorological data

    Science.gov (United States)

    Georgiana Stefan, Vivien; Merlin, Olivier; José Escorihuela, Maria; AïtHssaine, Bouchra; Molero, Beatriz; Ezzahar, Jamal; Er-Raki, Salah; Bitar, Ahmad Al; Kerr, Yann

    2016-04-01

    The majority of hydrological and agricultural applications require high-resolution soil moisture (SM) information. To improve the spatial resolution of SMOS (Soil Moisture and Ocean Salinity) SM, a downscaling algorithm is applied to the 40 km resolution SMOS level 3 product using 1 km resolution MODIS (MODerate resolution Imaging Spectroradiometer) shortwave and thermal data. The DISPATCH (DISaggregation based on a Physical and Theoretical Scale CHange) algorithm converts soil temperature data into SM data using a soil evaporative efficiency (SEE) model and a first order Taylor series expansion. The current version of DISPATCH is contextual, meaning that the MODIS-derived SEE is a function of temperature endmembers (Tends), which are determined from the image-based trapezoid method. However, limitations concerning the estimation of Tends arise when fully dry and fully wet conditions are not met within the scene at the observation resolution. Therefore, in order to improve DISPATCH's robustness in such conditions, the aim of this paper is to estimate Tends independently of shortwave/thermal data using an energy balance model forced by meteorological data. As a mean to evaluate the new algorithm, results are analyzed in terms of both disaggregated SM with respect to in situ 0-5 cm measurements and DISPATCH-derived SEE with respect to theoretical models. The approach is tested over a mixed irrigated and dry land area located in Catalunya, Spain, spanning 2011 and 2012. When comparing 40 km SMOS and 1 km disaggregated SM data with the in situ measurements, results indicate that DISPATCH improves the spatio-temporal correlation with in situ measurements. Moreover, disaggregation results are further improved by integrating the energy balance model in the methodology. The representation of SEE is also enhanced, proving that meteorological data foster the physical link between shortwave/thermal and SM data within the disaggregation method. The synergy between SEE modeling

  12. Effects of substrate differences on water availability for Arctic lichens during the snow-free summers in the High Arctic glacier foreland

    Science.gov (United States)

    Inoue, Takeshi; Kudoh, Sakae; Uchida, Masaki; Tanabe, Yukiko; Inoue, Masakane; Kanda, Hiroshi

    2014-12-01

    We used observational and experimental analyses to investigate the photosynthetic activity and water relationships of five lichen species attached to different substrates in a glacier foreland in the High Arctic, Ny-Ålesund, Svalbard (79°N) during the snow-free season in 2009 and 2010. After the rains ceased, lichens and their attached substrates quickly dried, whereas photosynthetic activity in the lichens decreased gradually. The in situ photosynthetic activity was estimated based on the relative electron transportation rate (rETR) in four fruticose lichens: Cetrariella delisei, Flavocetraria nivalis, Cladonia arbuscula ssp. mitis, and Cladonia pleurota. The rETR approached zero around noon, although the crustose lichen Ochrolechia frigida grown on biological soil crust (BSC) could acquire water from the BSC and retain its WC to perform positive photosynthesis. The light-rETR relationship curves of the five well-watered lichens were characterized into two types: shade-adapted with photoinhibition for the fruticose lichens, and light-adapted with no photoinhibition for O. frigida. The maximum rETR was expected to occur when they could acquire water from the surrounding air or from substrates during the desiccation period. Our results suggest that different species of Arctic lichens have different water availabilities due to their substrates and/or morphological characteristics, which affect their photosynthetic active periods during the summer.

  13. The ATLAS Software Installation System v2: a highly available system to install and validate Grid and Cloud sites via Panda

    CERN Document Server

    De Salvo, Alessandro; The ATLAS collaboration; Smirnov, Yuri; Sanchez, Arturo

    2015-01-01

    The ATLAS Installation System v2 is the evolution of the original system, used since 2003. The original tool has been completely re-designed in terms of database backend and components, adding support for submission to multiple backends, including the original WMS and the new Panda modules. The database engine has been changed from plain MySQL to Galera/Percona and the table structure has been optimized to allow a full High-Availability (HA) solution over WAN. The servlets, running on each frontend, have been also decoupled from local settings, to allow an easy scalability of the system, including the possibility of an HA system with multiple sites. The clients can also be run in multiple copies and in different geographical locations, and take care of sending the installation and validation jobs to the target Grid or Cloud sites. Moreover, the Installation DB is used as source of parameters by the automatic agents running in CVMFS, in order to install the software and distribute it to the sites. The system i...

  14. Myo-inositol hexakisphosphate degradation by Bifidobacterium pseudocatenulatum ATCC 27919 improves mineral availability of high fibre rye-wheat sour bread.

    Science.gov (United States)

    García-Mantrana, Izaskun; Monedero, Vicente; Haros, Monika

    2015-07-01

    The goal of this investigation was to develop baking products using Bifidobacterium pseudocatenulatum ATCC27919, a phytase producer, as a starter in sourdough for the production of whole rye-wheat mixed bread. This Bifidobacterium strain contributed to myo-inositol hexakisphosphate (phytate) hydrolysis, resulting in breads with higher mineral availability as was predicted by the phytate/mineral molar ratios, which remained below the inhibitory threshold values for Ca and Zn intestinal absorption. The products with sourdough showed similar technological quality as their homologous without sourdough, with levels of acetic and d/l lactic acids in dough and bread baking significantly higher with the use of sourdough. The overall acceptability scores showed that breads with 25% of whole rye flour were highly accepted regardless of the inclusion of sourdough. This work emphasises that the in situ production of phytase during fermentation by GRAS/QPS microorganisms constitutes a strategy which is particularly appropriate for reducing the phytate contents in products for human consumption.

  15. Required changes in emission standards for high-frequency noise in power systems

    Energy Technology Data Exchange (ETDEWEB)

    Lundmark, C.M.; Larsson, E.O.A. [Lulea Univ. of Technology, Skelleftea (Sweden); Bollen, M.H.J. [STRI AB, Ludvika (Sweden)

    2006-07-01

    This paper discusses some recent developments that make the existing standards on the emission of high-frequency noise in power systems due for reconsideration. It is shown that it is possible for an equipment to remain below the emission limits while at the same time the disturbance level increases beyond what was intended by the standard document. Further, the change from analog to digital communication and the use of communication via the power system, make that the permitted disturbance levels need to be reconsidered. This paper also contains an example of measured high-frequency noise and proposes a framework for re-coordination of emission and immunity levels. (Author)

  16. Required Actions to Place NCDs in Africa and the Global South High on the World Agenda

    Science.gov (United States)

    Moeti, Matshidiso R.; Munodawafa, Davison

    2016-01-01

    Africa and most of the global south continue to experience a striking burden of communicable diseases, neglected tropical diseases, and high rates of maternal and child mortality, as well as disastrous internecine conflicts and floods. While Africa has been making steady progress in addressing communicable diseases, it now faces new threats from…

  17. Requirements of High-Quality Kindergarten Programs According to Jordanian Parents: An Exploratory Study

    Science.gov (United States)

    Abu Taleb, Tagreed Fathi

    2013-01-01

    The main purpose of this study was to explore what Jordanian parents of children attending "traditional" kindergartens recognize as high-quality education programs. The sample consisted of 509 families ("N"?=?509) of kindergarten-age children. Data were collected using a three-part questionnaire: curriculum domains, teacher…

  18. Effect of high-dose phytase supplementation in broilers from 22 to 42 days post-hatch given diets severely limited in available phosphorus.

    Science.gov (United States)

    Taheri, H R; Heidari, A; Shahir, M H

    2015-01-01

    1. Two trials were conducted from 22 to 42 d post-hatch to evaluate the effectiveness of high concentrations of supplemental phytase in maize-soya bean meal-based diets severely limited in available phosphorus (P). Growth performance, plasma P and tibia ash (TA) were measured. 2. Each trial used 220 21-d-old male broilers in 20 pens with 11 birds per pen. Dietary treatments included a positive control [PC, 4.3 g/kg nonphytate P (NPP)], negative control [NC, 2.3 g/kg NPP (Trial 1) or 1.4 g/kg NPP (Trial 2)] and NC plus 1000, 2000 or 4000 phytase U/kg of the diet. 3. Birds fed on the PC diet had higher average daily gain (ADG), gain to feed ratio (G:F), plasma P (Trials 1 and 2) and TA (Trial 2) than those fed on the NC. 4. In Trial 1, ADG and G:F values of the NC plus 1000, 2000 or 4000 phytase U/kg reached those of the PC. Plasma P values of the NC plus 2000 or 4000 phytase U/kg reached that of the PC. Although TA values of the NC, NC + 1000 or NC + 2000 reached that of the PC, TA of the NC + 4000 was more than that of the PC. 5. In Trial 2, ADG and G:F values of the NC plus 4000 phytase U/kg reached those of the PC; nevertheless, plasma P values of the NC diets did not come up to that of the PC. While TA values of the NC, NC + 1000 or NC + 2000 did not reach that of the PC, TA of the NC + 4000 was greater than that of the PC. 6. Results of this study showed that, in the diets with 2.3 and 1.4 g/kg NPP, respectively, 1000 and 4000 phytase U/kg can be sufficient to obtain a comparable performance in broilers to those given diets adequate in available P.

  19. Claudin-1 required for HCV virus entry has high potential for phosphorylation and O-glycosylation

    OpenAIRE

    Fouzia Kiran; Kausar Humera; Gull Sana; Sarwar Muhammad T; Asad Sultan; Ijaz Bushra; Shabbiri Khadija; Ahmad Waqar; Shahid Imran; Hassan Sajida

    2011-01-01

    Abstract HCV is a leading cause of hepatocellular carcinoma and cirrhosis all over the world. Claudins belong to family of tight junction's proteins that are responsible for establishing barriers for controlling the flow of molecules around cells. For therapeutic strategies, regulation of viral entry into the host cells holds a lot of promise. During HCV infection claudin-1 is highly expressed in liver and believed to be associated with HCV virus entry after HCV binding with or without co-rec...

  20. Multiple PLDs required for high salinity and water deficit tolerance in plants.

    Science.gov (United States)

    Bargmann, Bastiaan O R; Laxalt, Ana M; ter Riet, Bas; van Schooten, Bas; Merquiol, Emmanuelle; Testerink, Christa; Haring, Michel A; Bartels, Dorothea; Munnik, Teun

    2009-01-01

    High salinity and drought have received much attention because they severely affect crop production worldwide. Analysis and comprehension of the plant's response to excessive salt and dehydration will aid in the development of stress-tolerant crop varieties. Signal transduction lies at the basis of the response to these stresses, and numerous signaling pathways have been implicated. Here, we provide further evidence for the involvement of phospholipase D (PLD) in the plant's response to high salinity and dehydration. A tomato (Lycopersicon esculentum) alpha-class PLD, LePLDalpha1, is transcriptionally up-regulated and activated in cell suspension cultures treated with salt. Gene silencing revealed that this PLD is indeed involved in the salt-induced phosphatidic acid production, but not exclusively. Genetically modified tomato plants with reduced LePLDalpha1 protein levels did not reveal altered salt tolerance. In Arabidopsis (Arabidopsis thaliana), both AtPLDalpha1 and AtPLDdelta were found to be activated in response to salt stress. Moreover, pldalpha1 and plddelta single and double knock-out mutants exhibited enhanced sensitivity to high salinity stress in a plate assay. Furthermore, we show that both PLDs are activated upon dehydration and the knock-out mutants are hypersensitive to hyperosmotic stress, displaying strongly reduced growth.

  1. Near Fault Observatories: multidisciplinary research infrastructures, high resolution data and scientific products available through dedicated services implemented within the EPOS-IP project

    Science.gov (United States)

    Festa, Gaetano; Chiaraluce, Lauro; Ergintav, Semih; Bernard, Pascal; Clinton, John; Marmureanu, Alexandru; Tataru, Dragos; Vogfjord, Kristin

    2017-04-01

    external platforms and services for accessing to standard data (e.g. seismic and geodetic) and on the direct access to the e-infrastructures of individual NFOs for distribution of non standard data (e.g. strain- and tilt-meters, geochemical data, electro- magneto-telluric data) and high-level data products. To define standards for formats and metadata, the TCS actively participates into the several harmonization groups across EPOS. Two main specific services are under implementation at the TCS level. FRIDGE (EU - NFO Specific Data and Products Gateway and Virtual Laboratory) is a NFO common gateway that enables the specific data and high-level data products availability also furnishing simple visualization tools. CREW (EU - Testing Centre for Early Warning and Source characterization) is a testing facility built on real-time and offline high-resolution data, whose focus is on operating and benchmarking various existing Earthquake Early Warning (EEW) methodologies. The backbone of the testing centre is the Irpinia NFO.

  2. Comparison of publically available Moho depth and crustal thickness grids with newly derived grids by 3D gravity inversion for the High Arctic region.

    Science.gov (United States)

    Lebedeva-Ivanova, Nina; Gaina, Carmen; Minakov, Alexander; Kashubin, Sergey

    2016-04-01

    We derived Moho depth and crustal thickness for the High Arctic region by 3D forward and inverse gravity modelling method in the spectral domain (Minakov et al. 2012) using lithosphere thermal gravity anomaly correction (Alvey et al., 2008); a vertical density variation for the sedimentary layer and lateral crustal variation density. Recently updated grids of bathymetry (Jakobsson et al., 2012), gravity anomaly (Gaina et al, 2011) and dynamic topography (Spasojevic & Gurnis, 2012) were used as input data for the algorithm. TeMAr sedimentary thickness grid (Petrov et al., 2013) was modified according to the most recently published seismic data, and was re-gridded and utilized as input data. Other input parameters for the algorithm were calibrated using seismic crustal scale profiles. The results are numerically compared with publically available grids of the Moho depth and crustal thickness for the High Arctic region (CRUST 1 and GEMMA global grids; the deep Arctic Ocean grids by Glebovsky et al., 2013) and seismic crustal scale profiles. The global grids provide coarser resolution of 0.5-1.0 geographic degrees and not focused on the High Arctic region. Our grids better capture all main features of the region and show smaller error in relation to the seismic crustal profiles compare to CRUST 1 and GEMMA grids. Results of 3D gravity modelling by Glebovsky et al. (2013) with separated geostructures approach show also good fit with seismic profiles; however these grids cover the deep part of the Arctic Ocean only. Alvey A, Gaina C, Kusznir NJ, Torsvik TH (2008). Integrated crustal thickness mapping and plate recon-structions for the high Arctic. Earth Planet Sci Lett 274:310-321. Gaina C, Werner SC, Saltus R, Maus S (2011). Circum-Arctic mapping project: new magnetic and gravity anomaly maps of the Arctic. Geol Soc Lond Mem 35, 39-48. Glebovsky V.Yu., Astafurova E.G., Chernykh A.A., Korneva M.A., Kaminsky V.D., Poselov V.A. (2013). Thickness of the Earth's crust in the

  3. Estimation of the Required Amount of Superconductors for High-field Accelerator Dipole Magnets

    CERN Document Server

    Schwerg, N

    2007-01-01

    The coil size and the corresponding amount of superconducting material that is used during the design process of a magnet cross-section have direct impacts on the overall magnet cost. It is therefore of interest to estimate the minimum amount of conductors needed to reach the defined field strength before a detailed design process starts. Equally, it is useful to evaluate the efficiency of a given design by calculating the amount of superconducting cables that are used to reach the envisaged main field by simple rule. To this purpose, the minimum amount of conductors for the construction of a dipole of given main field strength and aperture size is estimated taking the actual critical current density of the used strands into account. Characteristic curves applicable for the NED Nb3Sn strand specification are given and some of the recently studied different dipole configurations are compared. Based on these results, it is shown how the required amount of conductors changes due to the iron yoke contribution and...

  4. Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells.

    Science.gov (United States)

    Voloshanenko, Oksana; Erdmann, Gerrit; Dubash, Taronish D; Augustin, Iris; Metzig, Marie; Moffa, Giusi; Hundsrucker, Christian; Kerr, Grainne; Sandmann, Thomas; Anchang, Benedikt; Demir, Kubilay; Boehm, Christina; Leible, Svenja; Ball, Claudia R; Glimm, Hanno; Spang, Rainer; Boutros, Michael

    2013-01-01

    Aberrant regulation of the Wnt/β-catenin pathway has an important role during the onset and progression of colorectal cancer, with over 90% of cases of sporadic colon cancer featuring mutations in APC or β-catenin. However, it has remained a point of controversy whether these mutations are sufficient to activate the pathway or require additional upstream signals. Here we show that colorectal tumours express elevated levels of Wnt3 and Evi/Wls/GPR177. We found that in colon cancer cells, even in the presence of mutations in APC or β-catenin, downstream signalling remains responsive to Wnt ligands and receptor proximal signalling. Furthermore, we demonstrate that truncated APC proteins bind β-catenin and key components of the destruction complex. These results indicate that cells with mutations in APC or β-catenin depend on Wnt ligands and their secretion for a sufficient level of β-catenin signalling, which potentially opens new avenues for therapeutic interventions by targeting Wnt secretion via Evi/Wls.

  5. Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiation.

    Science.gov (United States)

    Matoba, Shogo; Hiramatsu, Ryuji; Kanai-Azuma, Masami; Tsunekawa, Naoki; Harikae, Kyoko; Kawakami, Hayato; Kurohmaru, Masamichi; Kanai, Yoshiakira

    2008-12-01

    In mouse sex differentiation, SRY promotes Sertoli cell differentiation via SOX9 action, resulting in testis formation. SRY/SOX9 also initiates various testis-specific morphogenic events including glycogenesis in pre-Sertoli cells, suggesting the importance of glucose storage for certain SRY/SOX9-downstream events in gonadal sex determination. However, it remains unclear which cell types and what molecular/cellular events require sex-dimorphic high-energy metabolic rate. Here we show that the establishment of SOX9 activation itself is a metabolically active process with sex-dimorphic high-energy requirements in gonadal sex differentiation. The glucose-deprivation and metabolic rescue experiments using genital ridge cultures of the XY/XX-wildtype and XX/Sry transgenic embryos demonstrated that, among the various somatic cell types, pre-Sertoli cells are the most sensitive to glucose starvation despite the differences between XX/Sry and XY genotypes. Moreover, our data showed that, in developing pre-Sertoli cells, the high-glucose metabolic state is required for the establishment of SOX9 expression through an ECM (extracellular matrix)-mediated feed-forward pathway. In contrast, the expression of SRY, SF1/Ad4Bp, GATA4 and WT1, as well as initiation of early SOX9 expression, is properly maintained in the glucose-deprived condition. Therefore, our results imply the metabolic importance of the high-glucose condition for the establishment of SOX9 activation in testis differentiation.

  6. Personal radiation detector at a high technology readiness level that satisfies DARPA’s SN-13-47 and SIGMA program requirements

    Energy Technology Data Exchange (ETDEWEB)

    Ginzburg, D., E-mail: dimgiz@rotemi.co.il [Radiation Detection Department, Rotem Industries Ltd. (Israel); Knafo, Y.; Manor, A. [Radiation Detection Department, Rotem Industries Ltd. (Israel); Seif, R.; Ghelman, M. [Electronics & Control Laboratories, Nuclear Research Center, Negev, Beersheba (Israel); Ellenbogen, M.; Pushkarsky, V. [Radiation Detection Department, Rotem Industries Ltd. (Israel); Ifergan, Y. [Electronics & Control Laboratories, Nuclear Research Center, Negev, Beersheba (Israel); Semyonov, N. [Radiation Detection Department, Rotem Industries Ltd. (Israel); Wengrowicz, U.; Mazor, T.; Kadmon, Y.; Cohen, Y. [Electronics & Control Laboratories, Nuclear Research Center, Negev, Beersheba (Israel); Osovizky, A. [Radiation Detection Department, Rotem Industries Ltd. (Israel)

    2015-06-01

    There is a need to develop new personal radiation detector (PRD) technologies that can be mass produced. On August 2013, DARPA released a request for information (RFI) seeking innovative radiation detection technologies. In addition, on December 2013, a Broad Agency Announcement (BAA) for the SIGMA program was released. The RFI requirements focused on a sensor that should possess three main properties: low cost, high compactness and radioisotope identification capabilities. The identification performances should facilitate the detection of a hidden threat, ranging from special nuclear materials (SNM) to commonly used radiological sources. Subsequently, the BAA presented the specific requirements at an instrument level and provided a comparison between the current market status (state-of-the-art) and the SIGMA program objectives. This work presents an optional alternative for both the detection technology (sensor with communication output and without user interface) for DARPA’s initial RFI and for the PRD required by the SIGMA program. A broad discussion is dedicated to the method proposed to fulfill the program objectives and to the selected alternative that is based on the PDS-GO design and technology. The PDS-GO is the first commercially available PRD that is based on a scintillation crystal optically coupled with a silicon photomultiplier (SiPM), a solid-state light sensor. This work presents the current performance of the instrument and possible future upgrades based on recent technological improvements in the SiPM design. The approach of utilizing the SiPM with a commonly available CsI(Tl) crystal is the key for achieving the program objectives. This approach provides the appropriate performance, low cost, mass production and small dimensions; however, it requires a creative approach to overcome the obstacles of the solid-state detector dark current (noise) and gain stabilization over a wide temperature range. Based on the presented results, we presume that

  7. Core promoter acetylation is not required for high transcription from the phosphoenolpyruvate carboxylase promoter in maize

    Directory of Open Access Journals (Sweden)

    Horst Ina

    2009-12-01

    Full Text Available Abstract Background Acetylation of promoter nucleosomes is tightly correlated and mechanistically linked to gene activity. However, transcription is not necessary for promoter acetylation. It seems, therefore, that external and endogenous stimuli control histone acetylation and by this contribute to gene regulation. Photosynthetic genes in plants are excellent models with which to study the connection between stimuli and chromatin modifications because these genes are strongly expressed and regulated by multiple stimuli that are easily manipulated. We have previously shown that acetylation of specific histone lysine residues on the photosynthetic phosphoenolpyruvate carboxylase (Pepc promoter in maize is controlled by light and is independent of other stimuli or gene activity. Acetylation of upstream promoter regions responds to a set of other stimuli which include the nutrient availability of the plant. Here, we have extended these studies by analysing histone acetylation during the diurnal and circadian rhythm of the plant. Results We show that histone acetylation of individual lysine residues is removed from the core promoter before the end of the illumination period which is an indication that light is not the only factor influencing core promoter acetylation. Deacetylation is accompanied by a decrease in gene activity. Pharmacological inhibition of histone deacetylation is not sufficient to prevent transcriptional repression, indicating that deacetylation is not controlling diurnal gene regulation. Variation of the Pepc promoter activity during the day is controlled by the circadian oscillator as it is maintained under constant illumination for at least 3 days. During this period, light-induced changes in histone acetylation are completely removed from the core promoter, although the light stimulus is continuously applied. However, acetylation of most sites on upstream promoter elements follows the circadian rhythm. Conclusion Our results

  8. The Effects of Different Tillage Methods on Available Soil Potassium Measured by Various Extractors in a Soil with High Specific Surface Area

    Directory of Open Access Journals (Sweden)

    M. Hosseini

    2016-02-01

    Full Text Available Introduction: The effects of any tillage method on soil properties, depends on location (soil, water and air and the number of (years their implementation. Soil compaction reduces yield through increased soil mechanical resistance against root growth and lower water and nutrient use efficiency (Gamda et al. 18 & Ishagh et al 23. Soil surface and sub surface compaction both reduce yield due to limited root growth and plant potassium uptake (Doulan et al. 14. Sabt et al. (50 reported that in the study area, which the lands are mostly illite clay (high specific surface area with sufficient nitrogen, soil potassium is the most important limiting factor for the growth of wheat.Considering the point that loess soils in Golestan Province have a high specific surface area,they can provide potassium for plants to produce crop, but for a higher production, potassium fertilizers should be used. Previous studies indicated that production of wheat is limited due to potassium deficiency (4, 49, 54 and 57. In these soils with a high specific surface area, the speed of movement of potassium from the soil solution is low, and doing solimits wheat yield.In loess soils containing high illite and high specific surface area (eg, soilsin the series of Rahmat Abad of Gorgan, ammonium acetate measured potassium on exchange and solution surfaces, which is highly correlated with grain yield (54 . There is a high correlation between grain yield with overload of potassium and Na TPB extraction (57. The aim of this study was to absorb potassium (limiting factor for plant growth with different tillage systemsat different depths. International recommendations towards reducing the depth and intensity of tillage (from minimum tillage to no-tillage in order to reduce erosion and oxidation of organic substances plays an important role in determining the amount of greenhouse gases. If potassium absorption does not reduceafter reducing tillage intensity,low or no-tillage methods

  9. Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity

    DEFF Research Database (Denmark)

    Holst, P J; Rosenkilde, M M; Manfra, D;

    2001-01-01

    ORF74 (or KSHV-vGPCR) is a highly constitutively active G protein-coupled receptor encoded by HHV8 that is regulated both positively and negatively by endogenous chemokines. When expressed in transgenic mice, this chemokine receptor induces an angioproliferative disease closely resembling Kaposi...... sarcoma (KS). Here we demonstrate that several lines of mice carrying mutated receptors deficient in either constitutive activity or chemokine regulation fail to develop KS-like disease. In addition, animals expressing a receptor that preserves chemokine binding and constitutive activity but that does...

  10. High-pressure discharges with imposed stability resulting in reduced power requirements

    Science.gov (United States)

    Brooks, N. H.; Jensen, T. H.; Moeller, C. M.

    2003-08-01

    High-pressure plasma discharge columns that are long and straight, as well as uniform in the axial direction, have been generated in a steady state. These discharges, stabilized by rotation of the containment envelope about a horizontal axis, have reduced heat transport to the wall due to the absence of buoyancy-driven radial convection and the elimination of eddies caused by sheared flow. These "rotating tube discharges" may take the form of electric arcs powered with dc or low-frequency ac; or of electrodeless plasmas, heated by electromagnetic waves at rf or microwave frequencies.

  11. Design study of technology requirements for high performance single-propeller-driven business airplanes

    Science.gov (United States)

    Kohlman, D. L.; Hammer, J.

    1985-01-01

    Developments in aerodyamic, structural and propulsion technologies which influence the potential for significant improvements in performance and fuel efficiency of general aviation business airplanes are discussed. The advancements include such technolgies as natural laminar flow, composite materials, and advanced intermittent combustion engines. The design goal for this parameter design study is a range of 1300 nm at 300 knots true airspeed with a payload of 1200lbs at 35,000 ft cruise altitude. The individual and synergistic effects of various advanced technologies on the optimization of this class of high performance, single engine, propeller driven business airplanes are identified.

  12. Low-versus high-glycemic index diets in women: effects on caloric requirement, substrate utilization and insulin sensitivity.

    Science.gov (United States)

    Clapp, James F; Lopez, Beth

    2007-09-01

    Lowering dietary glycemic index appears to have positive health effects in obese and/or insulin resistant individuals. However, detailed studies in lean young men show no effect. This study was designed to test the null hypothesis that a diet rich in low-glycemic carbohydrate has no effect on lipid profile, caloric requirements, fat oxidation, or insulin sensitivity in adult women when compared to one rich in high-glycemic carbohydrate. The metabolic feeding protocol used was conducted in both a free-living and in-patient setting using a randomized crossover design. Seven women were studied on each of 2 diets in which 60% of the calories were from either high- or low-glycemic carbohydrate sources. Each diet lasted 20 days with measurements of caloric requirement, resting metabolic rate, glucose and insulin responses to diet and activity, insulin sensitivity, and lipid profile over the last 7 days. Caloric requirement was determined by bomb calorimetry. Other techniques included indirect calorimetry, hydrodensitometry, stable isotope tracers, and the euglycemic clamp. On the low-glycemic index diet the women's caloric requirements were 11% +/- 1% higher, fat oxidation at fasted rest supplied an average of 45% +/- 4% versus 28% +/- 5% of oxidative requirements, average glucose and insulin levels were approximately 40% lower, low density lipoproteins (LDL) and leptin concentrations were lower, and various indices of insulin sensitivity were > 20% higher. In this group of adult women, a diet that lowered glycemic index well below that typically found in western diets increased both daily caloric requirement and fat oxidation, decreased insulin and glucose concentrations and increased insulin sensitivity.

  13. Requirement of ultra-high voltage GIS arrester to voltage gradient of metal-oxide varistor

    Institute of Scientific and Technical Information of China (English)

    HE JinLiang; HU Jun; MENG BoWen; ZHANG Bo; ZHU Bin; CHEN ShuiMing; ZENG Rong

    2009-01-01

    The surge arrestor with excellent protection characteristics would decrease the overvoltage level ap-plied on the power apparatus to reduce their insulation levels and manufacturing bottleneck. The ar-restor for the 1000-kV ultra-high voltage ac power transmission system is designed as tank-type structure. The field-circuit combination numerical method combining the three-dimensional finite ele-ment method with circuit is proposed to analyze the potential distribution of GIS arrester. By comparing several design schemes, the most effective method to improve the potential distribution along the varistor column is to increase the voltage gradient of the ZnO varistor. Synthesizing several influential factors, the suitable voltage gradient of ZnO varistor should be controlled to 435 V/mm, and the re-sulted nonuniform degree of the potential distribution along the varistor column inside the GIS arrestor would be controlled smaller than 10%. The result in this paper provides the fundamental technical in-dex for the study of the high voltage gradient ZnO varistors.

  14. Requirement of ultra-high voltage GIS arrester to voltage gradient of metal-oxide varistor

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The surge arrester with excellent protection characteristics would decrease the overvoltage level ap- plied on the power apparatus to reduce their insulation levels and manufacturing bottleneck. The arrester for the 1000-kV ultra-high voltage ac power transmission system is designed as tank-type structure. The field-circuit combination numerical method combining the three-dimensional finite element method with circuit is proposed to analyze the potential distribution of GIS arrester. By comparing several design schemes, the most effective method to improve the potential distribution along the varistor column is to increase the voltage gradient of the ZnO varistor. Synthesizing several influential factors, the suitable voltage gradient of ZnO varistor should be controlled to 435 V/mm, and the resulted nonuniform degree of the potential distribution along the varistor column inside the GIS arrester would be controlled smaller than 10%. The result in this paper provides the fundamental technical index for the study of the high voltage gradient ZnO varistors.

  15. Improving a DWT-based compression algorithm for high image-quality requirement of satellite images

    Science.gov (United States)

    Thiebaut, Carole; Latry, Christophe; Camarero, Roberto; Cazanave, Grégory

    2011-10-01

    Past and current optical Earth observation systems designed by CNES are using a fixed-rate data compression processing performed at a high-rate in a pushbroom mode (also called scan-based mode). This process generates fixed-length data to the mass memory and data downlink is performed at a fixed rate too. Because of on-board memory limitations and high data rate processing needs, the rate allocation procedure is performed over a small image area called a "segment". For both PLEIADES compression algorithm and CCSDS Image Data Compression recommendation, this rate allocation is realised by truncating to the desired rate a hierarchical bitstream of coded and quantized wavelet coefficients for each segment. Because the quantisation induced by truncation of the bit planes description is the same for the whole segment, some parts of the segment have a poor image quality. These artefacts generally occur in low energy areas within a segment of higher level of energy. In order to locally correct these areas, CNES has studied "exceptional processing" targeted for DWT-based compression algorithms. According to a criteria computed for each part of the segment (called block), the wavelet coefficients can be amplified before bit-plane encoding. As usual Region of Interest handling, these multiplied coefficients will be processed earlier by the encoder than in the nominal case (without exceptional processing). The image quality improvement brought by the exceptional processing has been confirmed by visual image analysis and fidelity criteria. The complexity of the proposed improvement for on-board application has also been analysed.

  16. Requirements for acquiring a high-quality house dust mite extract for allergen immunotherapy

    Directory of Open Access Journals (Sweden)

    Frati F

    2012-05-01

    Full Text Available Franco Frati,1 Cristoforo Incorvaia,2 Marie David,3 Silvia Scurati,3 Simona Seta,4 Guglielmo Padua,4 Eleonora Cattaneo,1 Carlo Cavaliere,5 Alessia Di Rienzo,6 Ilaria Dell'Albani,1 Paola Puccinelli11Medical and Scientific and Regulatory Department, Stallergenes, Milan, Italy; 2Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 3Laboratoire Stallergenes, Antony, France; 4Marketing Department, Stallergenes, Milan, Italy; 5Ear, Nose and Throat Department, University Sapienza, Rome, Italy; 6Azienda Sanitaria Locale, Allergology Service, Frosinone, ItalyAbstract: The house dust mite is a major cause of respiratory allergy worldwide. The management of mite allergy is based on avoidance measures, drug treatment, and allergen immunotherapy, but only allergen immunotherapy is able to modify the natural history of the disease. Injectable subcutaneous immunotherapy was introduced a century ago, while sublingual immunotherapy was proposed in the 1980s and emerged in the ensuing years as an effective and safe option to subcutaneous immunotherapy. However, the quality of the extracts to be used in allergen immunotherapy is crucial for the success of treatment. The mite extract for sublingual immunotherapy known as Staloral 300 was developed to offer optimal characteristics concerning the mite culture medium, standardization, and allergen dose. Double-blind, placebo-controlled trials with Staloral 300 have provided a substantial part of the clinical evidence analyzed in a meta-analysis of the efficacy of allergen immunotherapy in mite-induced rhinitis and asthma. Safety and tolerability are very good, mild local reactions in the mouth being the most common side effect. This makes it feasible to carry out sublingual immunotherapy for the 3–5-year duration needed to achieve long-lasting tolerance to the specific allergen. The performance of Staloral 300 may provide optimal conditions for an effective and safe sublingual immunotherapy in patients with

  17. 76 FR 71353 - Notice of Availability of the Record of Decision for the DesertXpress Enterprises, LLC High-Speed...

    Science.gov (United States)

    2011-11-17

    ... Enterprises, LLC High-Speed Passenger Train Project AGENCY: Bureau of Land Management, Interior. ACTION... Record of Decision (ROD) for the DesertXpress Enterprises, LLC High-Speed Passenger Train Project (Desert...-managed lands to build an Electrical Multiple Unit (EMU) high-speed passenger rail line in compliance...

  18. Effect of high-dose phytase and citric acid, alone or in combination, on growth performance of broilers given diets severely limited in available phosphorus.

    Science.gov (United States)

    Taheri, H R; Jabbari, Z; Adibnia, S; Shahir, M H; Hosseini, S A

    2015-01-01

    1. Two trials were conducted to evaluate the effect of high-dose phytase alone or in combination with citric acid (CA) in the diet severely limited in available phosphorus (P) on performance, plasma P and plasma Ca of broilers from 22 to 42 d of age. 2. In Trial 1, 297 21-d-old female chicks were placed into 27 pens and allocated to 9 maize-soybean meal-based dietary treatments, which were a positive control [PC, 4.23 g/kg non-phytate P (NPP)] and 8 negative control (NC, 1.35 g/kg NPP) groups consisting of two concentrations of CA (0 and 20 g/kg) and 4 concentrations of phytase (0, 1000, 2000 and 4000 U/kg) in a 2 × 4 factorial arrangement. In Trial 2, 192 21-d-old male chicks were placed into 24 pens and allocated to 6 wheat-canola meal-based dietary treatments, which were a PC (4.2 g/kg NPP), a NC (1.68 g/kg NPP) and 4 NC groups consisting of two concentrations of CA (0 and 20 g/kg) and two concentrations of phytase (2000 and 4000 U/kg) in a 2 × 2 factorial arrangement. 3. In both trials, birds fed on the PC had significantly higher average daily gain (ADG), average daily feed intake (ADFI), plasma P and lower feed conversion ratio (FCR) and plasma Ca than those of birds fed on the NC. CA supplementation significantly increased ADG and ADFI. There was a significant interaction between CA and phytase on plasma P where CA improved the effect of phytase on plasma P. In Trial 1, phytase addition improved ADG, ADFI, FCR and plasma Ca linearly. 4. Briefly, this research showed the interaction effect between CA and phytase on plasma P when broilers were fed on diets based on maize-soybean meal or wheat-canola meal. The results showed that CA supplementation lowered the concentration of phytase that is needed in low NPP diets to increase plasma P.

  19. Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.

    Science.gov (United States)

    Shulman, Ziv; Shinder, Vera; Klein, Eugenia; Grabovsky, Valentin; Yeger, Orna; Geron, Erez; Montresor, Alessio; Bolomini-Vittori, Matteo; Feigelson, Sara W; Kirchhausen, Tomas; Laudanna, Carlo; Shakhar, Guy; Alon, Ronen

    2009-03-20

    Endothelial chemokines are instrumental for integrin-mediated lymphocyte adhesion and transendothelial migration (TEM). By dissecting how chemokines trigger lymphocyte integrins to support shear-resistant motility on and across cytokine-stimulated endothelial barriers, we found a critical role for high-affinity (HA) LFA-1 integrin in lymphocyte crawling on activated endothelium. Endothelial-presented chemokines triggered HA-LFA-1 and adhesive filopodia at numerous submicron dots scattered underneath crawling lymphocytes. Shear forces applied to endothelial-bound lymphocytes dramatically enhanced filopodia density underneath crawling lymphocytes. A fraction of the adhesive filopodia invaded the endothelial cells prior to and during TEM and extended large subluminal leading edge containing dots of HA-LFA-1 occupied by subluminal ICAM-1. Memory T cells generated more frequent invasive filopodia and transmigrated more rapidly than their naive counterparts. We propose that shear forces exerted on HA-LFA-1 trigger adhesive and invasive filopodia at apical endothelial surfaces and thereby promote lymphocyte crawling and probing for TEM sites.

  20. Requirements Elicitation of Passengers With Reduced Mobility for the Design of High Quality, Accessible and Inclusive Public Transport Services

    Directory of Open Access Journals (Sweden)

    Starzyńska Beata

    2015-09-01

    Full Text Available In this article the authors present the methodology adopted and the results obtained in the first stage of the research encompassing focus group interviews (FGI about the needs of public transport users in a selected city (Poznań. The elicitation and assessment of the requirements were carried out for three groups of people with disabilities using public transport in the city of Poznań: blind and partially sighted people, deaf and hearing-impaired people, as well as people with locomotor dysfunctions. A study carried out on the basis of a scenario especially designed for the FGI purpose has made it possible to identify barriers for people with disabilities and, consequently, to formulate their pre-trip,on-trip and post-trip requirements when it comes to urban public transport services. The results will be used to construct a questionnaire to be used further on in the project.

  1. Negative inotropic actions of nitric oxide require high doses in rat cardiac muscle.

    Science.gov (United States)

    Wyeth, R P; Temma, K; Seifen, E; Kennedy, R H

    1996-08-01

    Initial experiments were designed to determine if vasoactive concentrations of nitric oxide (NO) alter contractility in rat heart. Contractile function was monitored in left atrial and papillary muscles (30 degrees C; paced at 0.5 Hz) during cumulative addition of 3-morpholino-sydnonimine-HCl(SIN-1), an agent that releases NO. At concentrations between 10(-7) and 10(-4) M (NO concentrations of approximately 10(-8)- 3 x 10(-7) M), SIN-1 did not affect contractility in either tissue. Similarly, 10(-4) M SIN-1 did not alter the positive inotropic responses to isoproterenol or increasing extracellular [Ca+2] ([Ca+2]o). To obtain higher concentrations of NO, additional studies were conducted using authentic NO. NO-saturated stock solutions and a corresponding control solvent were adjusted to pH 1.6 with HCl. Dose-dependent effects of NO were examined by adding aliquots of the stock solutions (or control solvent) to the bathing solution. At final concentrations of 1 x 10(-5)- 5 x 10(-4) M, NO produced transient, concentration-dependent decreases in contractility that were paralleled by reductions in buffer pH. Control solvent elicited similar reductions in pHo and transient decreases in contractility; however, the negative inotropic action elicited by the NO-containing solution was approximately 20% greater than that observed in control conditions. These data demonstrate that only high concentrations of NO depress contractility in isolated rat cardiac muscle, and suggest that this effect is mediated by both acidosis and a pHo-independent mechanism.

  2. The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae.

    Science.gov (United States)

    Casas, C; Aldea, M; Espinet, C; Gallego, C; Gil, R; Herrero, E

    1997-06-15

    High-affinity iron uptake in Saccharomyces cerevisiae involves the extracytoplasmic reduction of ferric ions by FRE1 and FRE2 reductases. Ferrous ions are then transported across the plasma membrane through the FET3 oxidase-FTR1 permease complex. Expression of the high-affinity iron uptake genes is induced upon iron deprivation. We demonstrate that AFT1 is differentially involved in such regulation. Aft1 protein is required for maintaining detectable non-induced level of FET3 expression and for induction of FRE2 in iron starvation conditions. On the contrary, FRE1 mRNA induction is normal in the absence of Aft1, although the existence of AFT1 point mutations causing constitutive expression of FRE1 (Yamaguchi-Iwai et al., EMBO J. 14: 1231-1239, 1995) indicates that Aft1 may also participate in FRE1 expression in a dispensable way. The alterations in the basal levels of expression of the high-affinity iron uptake genes may explain why the AFT1 mutant is unable to grow on respirable carbon sources. Overexpression of AFT1 leads to growth arrest of the G1 stage of the cell cycle. Aft1 is a transcriptional activator that would be part of the different transcriptional complexes interacting with the promoter of the high-affinity iron uptake genes. Aft1 displays phosphorylation modifications depending on the growth stage of the cells, and it might link induction of genes for iron uptake to other metabolically dominant requirement for cell growth.

  3. Availability analysis of high voltage substations considering its main equipment; Analise de disponibilidade de subestacoes de alta tensao considerando seus principais equipamentos

    Energy Technology Data Exchange (ETDEWEB)

    Santos, R.C. [Universidade Federal do ABC (UFABC), Santo Andre, SP (Brazil)], E-mail: ricardo.santos@ufabc.edu.br; Basseto, B.A.; Cugnasca, P.S.; Almeida Junior, J.R.; Camargo Junior, J.B. [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica], Emails: ricardo.santos@ufabc.edu.br, joao.camargo@poli.usp.br

    2009-07-01

    This paper evaluates the availability of electric power substations, based on Monte Carlo simulation and Fault Tree Analysis, which can be used in a larger way, considering various scenarios, usually founded. The main fallouts modes considered in the availability analysis of power systems, as well as the main methods applied to reach this goal are discussed. The availability indexes of the Monte Carlos simulation are sufficient to indicate the critical points of the power system, and to make comparisons between different substations, related to the performance levels. Through these indexes it is possible to evaluate the impact of a switching action in a determined substation. For this, the substation studied indexes are compared before and after the switching action be considered to the substation in reference.

  4. Task-dependent inhibition of slow-twitch soleus and excitation of fast-twitch gastrocnemius do not require high movement speed and velocity-dependent sensory feedback

    Directory of Open Access Journals (Sweden)

    Ricky eMehta

    2014-10-01

    Full Text Available Although individual heads of triceps surae, soleus (SO and medial gastrocnemius (MG muscles, are often considered close functional synergists, previous studies have shown distinct activity patterns between them in some motor behaviors. The goal of this study was to test two hypotheses explaining inhibition of slow SO with respect to fast MG: (1 inhibition occurs at high movement velocities and mediated by velocity-dependent sensory feedback and (2 inhibition depends on the ankle-knee joint moment combination and does not require high movement velocities. The hypotheses were tested by comparing the SO EMG/MG EMG ratio during fast and slow motor behaviors (cat paw shake responses vs. back, straight leg load lifting in humans, which had the same ankle extension-knee flexion moment combination; and during fast and slow behaviors with the ankle extension-knee extension moment combination (human vertical jumping and stance phase of walking in cats and leg load lifting in humans. In addition, SO EMG/MG EMG ratio was determined during cat paw shake responses and walking before and after removal of stretch velocity-dependent sensory feedback by self-reinnervating SO and/or gastrocnemius. We found the ratio SO EMG/MG EMG below 1 (p<0.05 during fast paw shake responses and slow back load lifting, requiring the ankle extension-knee flexion moment combination; whereas the ratio SO EMG/MG EMG was above 1 (p<0.05 during fast vertical jumping and slow tasks of walking and leg load lifting, requiring ankle extension-knee extension moments. Removal of velocity-dependent sensory feedback did not affect the SO EMG/MG EMG ratio in cats. We concluded that the relative inhibition of SO does not require high muscle velocities, depends on ankle-knee moment combinations, and is mechanically advantageous for allowing a greater MG contribution to ankle extension and knee flexion moments.

  5. Strawberry puree processed by thermal, high pressure, or power ultrasound: Process energy requirements and quality modeling during storage.

    Science.gov (United States)

    Sulaiman, Alifdalino; Farid, Mohammed; Silva, Filipa Vm

    2017-06-01

    Strawberry puree was processed for 15 min using thermal (65 ℃), high-pressure processing (600 MPa, 48 ℃), and ultrasound (24 kHz, 1.3 W/g, 33 ℃). These conditions were selected based on similar polyphenoloxidase inactivation (11%-18%). The specific energies required for the above-mentioned thermal, high-pressure processing, and power ultrasound processes were 240, 291, and 1233 kJ/kg, respectively. Then, the processed strawberry was stored at 3 ℃ and room temperature for 30 days. The constant pH (3.38±0.03) and soluble solids content (9.03 ± 0.25°Brix) during storage indicated a microbiological stability. Polyphenoloxidase did not reactivate during storage. The high-pressure processing and ultrasound treatments retained the antioxidant activity (70%-74%) better than the thermal process (60%), and high-pressure processing was the best treatment after 30 days of ambient storage to preserve antioxidant activity. Puree treated with ultrasound presented more color retention after processing and after ambient storage than the other preservation methods. For the three treatments, the changes of antioxidant activity and total color difference during storage were described by the fractional conversion model with rate constants k ranging between 0.03-0.09 and 0.06-0.22 day (- 1), respectively. In resume, high-pressure processing and thermal processes required much less energy than ultrasound for the same polyphenoloxidase inactivation in strawberry. While high-pressure processing retained better the antioxidant activity of the strawberry puree during storage, the ultrasound treatment was better in terms of color retention.

  6. High-level waste storage tank farms/242-A evaporator standards/requirements identification document (S/RID), Vol. 7

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    This Requirements Identification Document (RID) describes an Occupational Health and Safety Program as defined through the Relevant DOE Orders, regulations, industry codes/standards, industry guidance documents and, as appropriate, good industry practice. The definition of an Occupational Health and Safety Program as specified by this document is intended to address Defense Nuclear Facilities Safety Board Recommendations 90-2 and 91-1, which call for the strengthening of DOE complex activities through the identification and application of relevant standards which supplement or exceed requirements mandated by DOE Orders. This RID applies to the activities, personnel, structures, systems, components, and programs involved in maintaining the facility and executing the mission of the High-Level Waste Storage Tank Farms.

  7. The Olympic brain. Does corticospinal plasticity play a role in acquisition of skills required for high-performance sports?

    Science.gov (United States)

    Nielsen, Jens Bo; Cohen, Leonardo G

    2008-01-01

    Non-invasive electrophysiological and imaging techniques have recently made investigation of the intact behaving human brain possible. One of the most intriguing new research areas that have developed through these new technical advances is an improved understanding of the plastic adaptive changes in neuronal circuitries underlying improved performance in relation to skill training. Expansion of the cortical representation or modulation of corticomotor excitability of specific muscles engaged in task performance is required for the acquisition of the skill. These changes at cortical level appear to be paralleled by changes in transmission in spinal neuronal circuitries, which regulate the contribution of sensory feedback mechanisms to the execution of the task. Such adaptive changes also appear to be essential for the consolidation of a memory of performance of motor tasks and thus for the lasting ability of performing highly skilled movements such as those required for Olympic sports.

  8. High School Athletes' Parents' Perceptions and Knowledge of the Skills and Job Requirements of the Certified Athletic Trainer.

    Science.gov (United States)

    Weitzel, Rachel L; Miller, Michael G; Giannotta, Erin R; Newman, Catherine J

    2015-12-01

    Parents play a crucial role in determining medical services for their children, and it is important they understand the scope of practice and skills of the athletic trainer (AT). To understand parents' perceptions and knowledge of the skills and job requirements of the secondary school AT. Cross-sectional study. Sport meetings and banquets at 5 high schools in southwest Michigan during the fall, winter, and spring seasons. A total of 539 parents whose children competed in at least 1 high school sport participated. A Parents' Perceptions and Knowledge of Certified Athletic Trainers Survey consisting of 32 questions, divided into 3 sections (demographics, perceptions, and knowledge), was developed and given to parents of high school athletes. One-way analyses of variance were used to determine significance among 3 categories of experience and perception and knowledge of ATs. Of the 539 parents who responded, 28% responded yes, and 72% responded no to having experience with an AT for their own injuries. When asked if they had experience with an AT due to their child's injuries, 60% responded yes. We found a difference among the 3 categories of experience for perception scores (P = .002) and knowledge scores (P parents' perceptions and knowledge of the skills and job requirements of the secondary school AT are limited. Athletic trainers should educate parents on their professional roles, which may enhance their ability to provide better health care.

  9. Genes required for growth at high hydrostatic pressure in Escherichia coli K-12 identified by genome-wide screening.

    Science.gov (United States)

    Black, S Lucas; Dawson, Angela; Ward, F Bruce; Allen, Rosalind J

    2013-01-01

    Despite the fact that much of the global microbial biosphere is believed to exist in high pressure environments, the effects of hydrostatic pressure on microbial physiology remain poorly understood. We use a genome-wide screening approach, combined with a novel high-throughput high-pressure cell culture method, to investigate the effects of hydrostatic pressure on microbial physiology in vivo. The Keio collection of single-gene deletion mutants in Escherichia coli K-12 was screened for growth at a range of pressures from 0.1 MPa to 60 MPa. This led to the identification of 6 genes, rodZ, holC, priA, dnaT, dedD and tatC, whose products were required for growth at 30 MPa and a further 3 genes, tolB, rffT and iscS, whose products were required for growth at 40 MPa. Our results support the view that the effects of pressure on cell physiology are pleiotropic, with DNA replication, cell division, the cytoskeleton and cell envelope physiology all being potential failure points for cell physiology during growth at elevated pressure.

  10. The Physiological Response of Two Green Calcifying Algae from the Great Barrier Reef towards High Dissolved Inorganic and Organic Carbon (DIC and DOC) Availability

    Science.gov (United States)

    Meyer, Friedrich Wilhelm; Vogel, Nikolas; Teichberg, Mirta; Uthicke, Sven; Wild, Christian

    2015-01-01

    Increasing dissolved inorganic carbon (DIC) concentrations associated with ocean acidification can affect marine calcifiers, but local factors, such as high dissolved organic carbon (DOC) concentrations through sewage and algal blooms, may interact with this global factor. For calcifying green algae of the genus Halimeda, a key tropical carbonate producer that often occurs in coral reefs, no studies on these interactions have been reported. These data are however urgently needed to understand future carbonate production. Thus, we investigated the independent and combined effects of DIC (pCO2 402 μatm/ pHtot 8.0 and 996 μatm/ pHtot 7.7) and DOC (added as glucose in 0 and 294 μmol L-1) on growth, calcification and photosynthesis of H. macroloba and H. opuntia from the Great Barrier Reef in an incubation experiment over 16 days. High DIC concentrations significantly reduced dark calcification of H. opuntia by 130 % and led to net dissolution, but did not affect H. macroloba. High DOC concentrations significantly reduced daily oxygen production of H. opuntia and H. macroloba by 78 % and 43 %, respectively, and significantly reduced dark calcification of H. opuntia by 70%. Combined high DIC and DOC did not show any interactive effects for both algae, but revealed additive effects for H. opuntia where the combination of both factors reduced dark calcification by 162 % compared to controls. Such species-specific differences in treatment responses indicate H. opuntia is more susceptible to a combination of high DIC and DOC than H. macroloba. From an ecological perspective, results further suggest a reduction of primary production for Halimeda-dominated benthic reef communities under high DOC concentrations and additional decreases of carbonate accretion under elevated DIC concentrations, where H. opuntia dominates the benthic community. This may reduce biogenic carbonate sedimentation rates and hence the buffering capacity against further ocean acidification. PMID

  11. The physiological response of two green calcifying algae from the Great Barrier Reef towards high dissolved inorganic and organic carbon (DIC and DOC) availability.

    Science.gov (United States)

    Meyer, Friedrich Wilhelm; Vogel, Nikolas; Teichberg, Mirta; Uthicke, Sven; Wild, Christian

    2015-01-01

    Increasing dissolved inorganic carbon (DIC) concentrations associated with ocean acidification can affect marine calcifiers, but local factors, such as high dissolved organic carbon (DOC) concentrations through sewage and algal blooms, may interact with this global factor. For calcifying green algae of the genus Halimeda, a key tropical carbonate producer that often occurs in coral reefs, no studies on these interactions have been reported. These data are however urgently needed to understand future carbonate production. Thus, we investigated the independent and combined effects of DIC (pCO2 402 μatm/ pHtot 8.0 and 996 μatm/ pHtot 7.7) and DOC (added as glucose in 0 and 294 μmol L-1) on growth, calcification and photosynthesis of H. macroloba and H. opuntia from the Great Barrier Reef in an incubation experiment over 16 days. High DIC concentrations significantly reduced dark calcification of H. opuntia by 130 % and led to net dissolution, but did not affect H. macroloba. High DOC concentrations significantly reduced daily oxygen production of H. opuntia and H. macroloba by 78 % and 43 %, respectively, and significantly reduced dark calcification of H. opuntia by 70%. Combined high DIC and DOC did not show any interactive effects for both algae, but revealed additive effects for H. opuntia where the combination of both factors reduced dark calcification by 162 % compared to controls. Such species-specific differences in treatment responses indicate H. opuntia is more susceptible to a combination of high DIC and DOC than H. macroloba. From an ecological perspective, results further suggest a reduction of primary production for Halimeda-dominated benthic reef communities under high DOC concentrations and additional decreases of carbonate accretion under elevated DIC concentrations, where H. opuntia dominates the benthic community. This may reduce biogenic carbonate sedimentation rates and hence the buffering capacity against further ocean acidification.

  12. The association between high recreational physical activity and physical activity as a part of daily living in adolescents and availability of local indoor sports facilities and sports clubs

    DEFF Research Database (Denmark)

    Niclasen, B.; Petzold, M.; Schnohr, Christina Warrer

    2012-01-01

    members) in Greenlandic adolescents. Material and methods: Data from the 2006 Health Behaviour in School-aged Children survey including 2,430 children aged 11-17 years was used. Logistic regression models were developed with dichotomous measures on VPA and MVPA as outcomes, number of indoor sports...... facilities and of sports clubs with child members as independent variables, and adjusted for age, gender, family affluence (FAS), and type of habitation (capital, town or village). Results: High VPA increased with access to indoor facilities, while high MVPA was less likely (odds ratio (OR) 0.54 (0...

  13. On-pump beating heart coronary surgery for high risk patients requiring emergency multiple coronary artery bypass grafting.

    Science.gov (United States)

    Ferrari, Enrico; Stalder, Nicolas; von Segesser, Ludwig K

    2008-07-02

    Cardiopulmonary bypass (CPB) with aortic cross-clamping and cardioplegic arrest remains the method of choice for patients requiring standard myocardial revascularization. Therefore, very high-risk patients presenting with acute coronary syndrome, unstable angina, onset of cardiac decompensation and requiring emergency multiple myocardial revascularization, can have a poor outcome. The on-pump beating heart technique can reduce the mortality and the morbidity in such a selected group of patients and this report describes our clinical experience. Out of 290 patients operated for CABG from January 2005 to January 2006, 25 (8.6%) selected high-risk patients suffering from life threatening coronary syndrome (mean age 69 +/- 7 years) and requiring emergency multiple myocardial revascularization, underwent on-pump beating heart surgery. The mean pre-operative left ventricle ejection fraction (LVEF) was 27 +/- 8%. The majority of them (88%) suffered of tri-vessel coronary disease and 6 (24%) had a left main stump disease. Nine patients (35%) were on severe cardiac failure and seven among them (28%) received a pre-operative intra-aortic balloon pump. The pre-operative EuroScore rate was equal or above 8 in 18 patients (73%). All patients underwent on-pump-beating heart coronary revascularization. The mean number of graft/patient was 2.9 +/- 0.6 and the internal mammary artery was used in 23 patients (92%). The mean CPB time was 84 +/- 19 minutes. Two patients died during the recovery stay in the intensive care unit, and there were no postoperative myocardial infarctions between the survivors. Eight patients suffered of transitorily renal failure and 1 patient developed a sternal wound infection. The mean hospital stay was 12 +/- 7 days. The follow-up was complete for all 23 patients survived at surgery and the mean follow-up time was 14 +/- 5 months. One patient died during the follow-up for cardiac arrest and 2 patients required an implantable cardiac defibrillator. One

  14. High-order adaptive optics requirements for direct detection of extrasolar planets: Application to the SPHERE instrument.

    Science.gov (United States)

    Fusco, T; Rousset, G; Sauvage, J-F; Petit, C; Beuzit, J-L; Dohlen, K; Mouillet, D; Charton, J; Nicolle, M; Kasper, M; Baudoz, P; Puget, P

    2006-08-21

    The detection of extrasolar planets implies an extremely high-contrast, long-exposure imaging capability at near infrared and probably visible wavelengths. We present here the core of any Planet Finder instrument, that is, the extreme adaptive optics (XAO) subsystem. The level of AO correction directly impacts the exposure time required for planet detection. In addition, the capacity of the AO system to calibrate all the instrument static defects ultimately limits detectivity. Hence, the extreme AO system has to adjust for the perturbations induced by the atmospheric turbulence, as well as for the internal aberrations of the instrument itself. We propose a feasibility study for an extreme AO system in the frame of the SPHERE (Spectro-Polarimetry High-contrast Exoplanet Research) instrument, which is currently under design and should equip one of the four VLT 8-m telescopes in 2010.

  15. Bottom-up effects of nutrient availability on flower production, pollinator visitation, and seed output in a high-Andean shrub.

    Science.gov (United States)

    Muñoz, Alejandro A; Celedon-Neghme, Constanza; Cavieres, Lohengrin A; Arroyo, Mary T K

    2005-03-01

    Soil nutrient availability directly enhances vegetative growth, flowering, and fruiting in alpine ecosystems. However, the impacts of nutrient addition on pollinator visitation, which could affect seed output indirectly, are unknown. In a nutrient addition experiment, we tested the hypothesis that seed output in the insect-pollinated, self-incompatible shrub, Chuquiraga oppositifolia (Asteraceae) of the Andes of central Chile, is enhanced by soil nitrogen (N) availability. We aimed to monitor total shrub floral display, size of flower heads (capitula), pollinator visitation patterns, and seed output during three growing seasons on control and N addition shrubs. N addition did not augment floral display, size of capitula, pollinator visitation, or seed output during the first growing season. Seed mass and viability were 25-40% lower in fertilised shrubs. During the second growing season only 33% of the N addition shrubs flowered compared to 71% of controls, and a significant (50%) enhancement in vegetative growth occurred in fertilised shrubs. During the third growing season, floral display in N addition shrubs was more than double that of controls, received more than twice the number of insect pollinator visits, and seed output was three- to four-fold higher compared to controls. A significant (50%) enhancement in vegetative growth again occurred in N addition shrubs. Results of this study strongly suggest that soil N availability produces strong positive bottom-up effects on the reproductive output of the alpine shrub C. oppositifolia. Despite taking considerably longer to be manifest in comparison to the previously reported top-down indirect negative effects of lizard predators in the same study system, our results suggest that both bottom-up and top-down forces are important in controlling the reproductive output of an alpine shrub.

  16. High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal

    LENUS (Irish Health Repository)

    Kilbride, Sean M

    2011-07-26

    Abstract Background The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2) and complex IV (cytochrome c oxidase EC 1.9.3.1) are reduced by 30-70% in Huntington\\'s disease and Alzheimer\\'s disease, respectively, and are associated with excitotoxic cell death in these disorders. In this study, we investigated the control that complexes III and complex IV exert on glutamate release from the isolated nerve terminal. Results Inhibition of complex III activity by 60-90% was necessary for a major increase in the rate of Ca2+-independent glutamate release to occur from isolated nerve terminals (synaptosomes) depolarized with 4-aminopyridine or KCl. Similarly, an 85-90% inhibition of complex IV activity was required before a major increase in the rate of Ca2+-independent glutamate release from depolarized synaptosomes was observed. Inhibition of complex III and IV activities by ~ 60% and above was required before rates of glutamate efflux from polarized synaptosomes were increased. Conclusions These results suggest that nerve terminal mitochondria possess high reserves of complex III and IV activity and that high inhibition thresholds must be reached before excess glutamate is released from the nerve terminal. The implications of the results in the context of the relationship between electron transport chain enzyme deficiencies and excitotoxicity in neurodegenerative disorders are discussed.

  17. High-quality imaging in environmental scanning electron microscopy--optimizing the pressure limiting system and the secondary electron detection of a commercially available ESEM.

    Science.gov (United States)

    Fitzek, H; Schroettner, H; Wagner, J; Hofer, F; Rattenberger, J

    2016-04-01

    In environmental scanning electron microscopy applications in the kPa regime are of increasing interest for the investigation of wet and biological samples, because neither sample preparation nor extensive cooling are necessary. Unfortunately, the applications are limited by poor image quality. In this work the image quality at high pressures of a FEI Quanta 600 (field emission gun) and a FEI Quanta 200 (thermionic gun) is greatly improved by optimizing the pressure limiting system and the secondary electron (SE) detection system. The scattering of the primary electron beam strongly increases with pressure and thus the image quality vanishes. The key to high-image quality at high pressures is to reduce scattering as far as possible while maintaining ideal operation conditions for the SE-detector. The amount of scattering is reduced by reducing both the additional stagnation gas thickness (aSGT) and the environmental distance (ED). A new aperture holder is presented that significantly reduces the aSGT while maintaining the same field-of-view (FOV) as the original design. With this aperture holder it is also possible to make the aSGT even smaller at the expense of a smaller FOV. A new blade-shaped SE-detector is presented yielding better image quality than usual flat SE-detectors. The electrode of the new SE detector is positioned on the sample table, which allows the SE-detector to operate at ideal conditions regardless of pressure and ED.

  18. Cyclic electron flow around photosystem I is required for adaptation to high temperature in a subtropical forest tree, Ficus concinna

    Institute of Scientific and Technical Information of China (English)

    Song-heng JIN; Xue-qin LI; Jun-yan HU; Jun-gang WANG

    2009-01-01

    Dissipation mechanisms of excess photon energy under high-temperature stress were studied in a subtropical forest tree seedling, Ficus concinna. Net CO2 assimilation rate decreased to 16% of the control after 20 of high-temperature stress, and thus the absorption of photon energy exceeded the energy required for CO2 assimilation. The efficiency of excitation energy capture by open photosystem Ⅱ (PSII) reaction centres (Fv'/Fm') at moderate irradiauce, photochemical quenching (qp), and the quantum yield of PSII electron transport (φPSII) were significantly lower after high-temperature stress. Nevertheless, non-photochemical quenching (qHP) and energy-dependent quenching (qE) were significantly higher under such conditions. The post-irradiation transient of chlorophyll (Chl) fluorescence significantly increased after the turnoff of the actinic light (AL), and this increase was considerably higher in the 39 ℃-grown seedlings than in the 30 ℃-grown ones. The increased post-irradiation fluorescence points to enhanced cyclic electron transport around PSI under high growth temperature conditions, thus helping to dissipate excess photon energy non-radiatively.

  19. Interference of paracetamol (acetaminophen) with a commercially available high-performance liquid chromatography analysis of serotonin leading to falsely low serotonin levels.

    Science.gov (United States)

    Pfäfflin, Albrecht; Müssig, Karsten; Schleicher, Erwin

    2009-03-01

    Serotonin is frequently analysed by high-performance liquid chromatography (HPLC) with electrochemical detection. However, the accuracy of these methods may be affected by the presence of certain drugs. We describe for the first time the interference of paracetamol in therapeutic dosages in a routine HPLC method for serotonin determination in vivo and in vitro. The retention time coincides with N-methylserotonin used as an internal standard in this method. Erroneous increases of the internal standard will lead, if not recognized and corrected, to falsely low serotonin determinations.

  20. 基于K-V模式的高可用性分布式存储技术研究%Research on High-Availability Distributed Storage Technology Based on K-V Mode

    Institute of Scientific and Technical Information of China (English)

    罗常

    2014-01-01

    随着互联网的普及,用户量的日益增多,每天互联网上产生的数据高达T级别甚至P级别,因此对数据的存储提出了更高的要求。针对K-V模式的高可用分布式存储技术进行研究,重点分析Dynamo系统的高移植性、高可用性、高扩展性特点,并对Dynamo系统中涉及的分布式哈希算法、哈希树、Gossip协议进行阐述。%With the development of Internet, computers become a common tool in daily life and more and more people enjoy surfing the Internet. With the increasing number of customers on Internet, companies have to deal with data in TB or even PB every day, resulting in higher requirement of database to cope with large scale data. This paper mainly focuses on the research on one of the distribute database, and distribute database will and must be applied widely in practice, due to its high availability, real-time, and great extensibility.

  1. Accelerator Availability and Reliability Issues

    Energy Technology Data Exchange (ETDEWEB)

    Steve Suhring

    2003-05-01

    Maintaining reliable machine operations for existing machines as well as planning for future machines' operability present significant challenges to those responsible for system performance and improvement. Changes to machine requirements and beam specifications often reduce overall machine availability in an effort to meet user needs. Accelerator reliability issues from around the world will be presented, followed by a discussion of the major factors influencing machine availability.

  2. Therapeutic ultrasound as a potential male contraceptive: power, frequency and temperature required to deplete rat testes of meiotic cells and epididymides of sperm determined using a commercially available system

    Directory of Open Access Journals (Sweden)

    Tsuruta James K

    2012-01-01

    Full Text Available Abstract Background Studies published in the 1970s by Mostafa S. Fahim and colleagues showed that a short treatment with ultrasound caused the depletion of germ cells and infertility. The goal of the current study was to determine if a commercially available therapeutic ultrasound generator and transducer could be used as the basis for a male contraceptive. Methods Sprague-Dawley rats were anesthetized and their testes were treated with 1 MHz or 3 MHz ultrasound while varying power, duration and temperature of treatment. Results We found that 3 MHz ultrasound delivered with 2.2 Watt per square cm power for fifteen minutes was necessary to deplete spermatocytes and spermatids from the testis and that this treatment significantly reduced epididymal sperm reserves. 3 MHz ultrasound treatment reduced total epididymal sperm count 10-fold lower than the wet-heat control and decreased motile sperm counts 1,000-fold lower than wet-heat alone. The current treatment regimen provided nominally more energy to the treatment chamber than Fahim's originally reported conditions of 1 MHz ultrasound delivered at 1 Watt per square cm for ten minutes. However, the true spatial average intensity, effective radiating area and power output of the transducers used by Fahim were not reported, making a direct comparison impossible. We found that germ cell depletion was most uniform and effective when we rotated the therapeutic transducer to mitigate non-uniformity of the beam field. The lowest sperm count was achieved when the coupling medium (3% saline was held at 37 degrees C and two consecutive 15-minute treatments of 3 MHz ultrasound at 2.2 Watt per square cm were separated by 2 days. Conclusions The non-invasive nature of ultrasound and its efficacy in reducing sperm count make therapeutic ultrasound a promising candidate for a male contraceptive. However, further studies must be conducted to confirm its efficacy in providing a contraceptive effect, to test the

  3. Requerimientos y disponibilidad de arenas parala defensa de las playas de Necochea y Lobería Requirements and availability of sand for theprotection of Nechochea and Lobería beaches

    Directory of Open Access Journals (Sweden)

    Federico Isla

    2009-11-01

    Full Text Available La costa de Lobería y Necochea se caracteriza poracantilados y playas de escaso desarrollo. La desembocadura del río QuequénGrande alteraba la línea de costa. La construcción de las escolleras del puertode Quequén indujo una gran acumulación de arena en el sector de Necochea, y uncrítico proceso erosivo de los acantilados y en las playas del este. El anchode las playas se reduce de 300 m en el oeste a sólo 40-60 m hacia el este.Considerando la escasez generalizada de arena, las playas del este son las quetienen mayor variabilidad sedimentaria. Las mayores variaciones en los balancesde arena fueron originadas por actividades humanas. Las olas provenientes delE, SE y S proyectan mayor energía en este sector oriental. Por otro lado, lossectores infralitorales de estas playas tienen poca disponibilidad de arena. Lamayor abundancia de arena fina ha sido reconocida hacia el balneario Necochea.El río Quequén Grande tiene un significativo efecto sobre la dinámica delestuario durante las crecidas originadas por eventos ENSO, aunque la sedimentaciónestá dominada por aportes de limo.Thecoast of Lobería and Necochea is characterized by cliffsand narrow beaches. Theinlet of the Quequén Grande river used to alter the coastline. The constructionof jetties related to the Quequén Harbour induced huge accumulations of sandtowards Necochea, and a critic erosive process of cliff and beach to the east.Beach width reduces from 300 m at the west to 40-60 m to the east. Consideringregional sand scarcity, the eastern beaches are characterized by more sandvariability. Greater variations in the sand balance were assigned to humanactivity. Waves coming from the E, SE and S deliver more energy along thiseastern sector. On the other hand, submerged zones of these beaches have lessavailability of sand. Greater availability of fine sand was recognized towardsNecochea. The Quequén Grande river has much effect on the estuarine dynamicsduring ENSO

  4. 高有效氮可降低泥炭藓泥炭中的多酚含量%High Nitrogen Availability Reduces Polyphenol Content in Sphagnum Peat

    Institute of Scientific and Technical Information of China (English)

    Luca Bragazza; Chris Freeman; 谷晓楠(译); 葛佳丽(译)

    2014-01-01

    泥炭藓是雨养泥炭沼泽中的优势植物和主要造炭植物。多酚类化合物通常被视为是一种植物防御性化合物的次生代谢产物。泥炭藓含有独特的多酚,可抑制微生物活性,减缓泥炭残体分解。在自然生态系统中生物活性氮不断增加的背景下,泥炭藓残体成为检测大气氮沉降对泥炭残体多酚含量潜在影响的理想基质。本研究选择长期大气氮沉降梯度上的11处欧洲雨养泥炭地,测试了泥炭藓泥炭样本的总氮含量和可溶性多酚浓度。试验结果表明,由于外源性有效氮的增加,导致泥炭藓残体中氮浓度持续增长,残体中多酚含量降低。这种负相关关系与有关泥炭藓中多酚与蛋白质生物合成争夺相同前体的报道相一致。由于有效氮的抑制分解作用,导致多酚含量下降,加快泥炭残体的分解,因此长期氮富集所导致的泥炭藓残体化学特征变化将对全球碳平衡产生重要影响。%Peat mosses of the genus Sphagnum constitute the bulk of living and dead biomass in bogs. Polyphenols are a wide group of secondary metabolites that are often regarded as plant defensive compounds. These plants contain pe-culiar polyphenols which hamper litter peat decomposition through their inhibitory activity on microbial breakdown. In the light of the increasing availability of biologically active nitrogen in natural ecosystems, litter derived from Sphag-num mosses is an ideal substrate to test the potential effects of increased atmospheric nitrogen deposition on polyphenol content in litter peat. To this aim,we measured total nitrogen and soluble polyphenol concentration in Sphagnum litter peat collected in 11 European bogs under a chronic gradient of atmospheric nitrogen deposition. Our results demonstrate that increasing nitrogen concentration in Sphagnum litter, as a consequence of increased exogenous nitrogen availabil-ity, is accompanied by a decreasing

  5. Speciation of the bio-available iodine and bromine forms in edible seaweed by high performance liquid chromatography hyphenated with inductively coupled plasma-mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Romaris-Hortas, Vanessa; Bermejo-Barrera, Pilar [Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Chemistry, University of Santiago de Compostela, Avenida das Ciencias, s/n. 15782 - Santiago de Compostela (Spain); Moreda-Pineiro, Jorge [Department of Analytical Chemistry, Faculty of Sciences, University of A Coruna, Campus da Zapateira, s/n. 15071, A Coruna (Spain); Moreda-Pineiro, Antonio, E-mail: antonio.moreda@usc.es [Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Chemistry, University of Santiago de Compostela, Avenida das Ciencias, s/n. 15782 - Santiago de Compostela (Spain)

    2012-10-01

    Highlights: Black-Right-Pointing-Pointer Bioavailable iodine and bromine speciation in edible seaweed were developed. Black-Right-Pointing-Pointer In vitro dialyzability was used to assess the bioavailable fractions. Black-Right-Pointing-Pointer AEC hyphenated with inductively coupled plasma-mass spectrometry was used. Black-Right-Pointing-Pointer Iodide, MIT, DIT, bromide and bromate were found in dialyzates from edible seaweed. Black-Right-Pointing-Pointer Positive correlation between bioavailability and protein contents was found. - Abstract: A bioavailability study based on an in vitro dialyzability approach has been applied to assess the bio-available fractions of iodine and bromine species from edible seaweed. Iodide, iodate, 3-iodo-tyrosine (MIT), 3,5-diiodo-tyrosine (DIT), bromide and bromate were separated by anion exchange chromatography under a gradient elution mode (175 mM ammonium nitrate plus 15% (v/v) methanol, pH 3.8, as a mobile phase, and flow rates within the 0.5-1.5 mL min{sup -1} range). Inductively coupled plasma-mass spectrometry (ICP-MS) was used as a selective detector for iodine ({sup 127}I) and bromine ({sup 79}Br). Low dialyzability ratios (within the 2.0-18% range) were found for iodine species; whereas, moderate dialyzability percentages (from 9.0 to 40%) were obtained for bromine species. Iodide and bromide were the major species found in the dialyzates from seaweed, although MIT and bromate were also found in the dialyzates from most of the seaweed samples analysed. However, DIT was only found in dialyzates from Wakame, Kombu, and NIES 09 (Sargasso) certified reference material; whereas, iodate was not found in any dialyzate. Iodine dialyzability was found to be dependent on the protein content (negative correlation), and on the carbohydrate and dietary fibre levels (positive correlation). However, bromine dialyzability was only dependent on the protein amount in seaweed (negative correlation).

  6. Availability growth modeling

    Energy Technology Data Exchange (ETDEWEB)

    Wendelberger, J.R.

    1998-12-01

    In reliability modeling, the term availability is used to represent the fraction of time that a process is operating successfully. Several different definitions have been proposed for different types of availability. One commonly used measure of availability is cumulative availability, which is defined as the ratio of the amount of time that a system is up and running to the total elapsed time. During the startup phase of a process, cumulative availability may be treated as a growth process. A procedure for modeling cumulative availability as a function of time is proposed. Estimates of other measures of availability are derived from the estimated cumulative availability function. The use of empirical Bayes techniques to improve the resulting estimates is also discussed.

  7. Construction of Cluster System with High Availability Based on ServiceGuard%基于ServiceGuard构建医院高可用性集群系统

    Institute of Scientific and Technical Information of China (English)

    钱硕

    2014-01-01

    Objective To construct a dual-computer cluster system with high reliability and efifciency to ensure the security of hospital information system.Methods The system was constructed with MC/Service Guard cluster infrastructure and HP Unix operating system according to the server items of the new databases in the hospital.Results The stable and smooth operation of hospital businesses has been ensured with the application of the system which runs well in the hospital.Conclusion The security and disaster tolerance have been improved with the application of the system.%目的:建立高可靠性和高效的双机集群系统,保障医院信息系统(HIS)的安全。方法根据医院新数据库服务器项目,基于HP Unix操作系统、MC/ServiceGuard集群基础架构构建双机集群系统。结果双机集群系统可提高HIS的安全性和抗灾能力,确保了医院业务的平稳流畅运行。结论使用ServiceGuard软件构建双机集群系统的方法易操作,值得推广。

  8. The effects of olive mill waste compost and poultry manure on the availability and plant uptake of nutrients in a highly saline soil.

    Science.gov (United States)

    Walker, David J; Bernal, M Pilar

    2008-01-01

    The effects of a compost (produced from by-products of the olive oil industry) and a poultry manure on mineral ion solubility and exchangeability in a highly saline agricultural soil (electrical conductivity for a 1:5 soil:water extract=1.85 dS m(-1)) from Murcia (SE Spain) were studied. The organic amendments did not change significantly the soil electrical conductivity or the soluble Na(+), Ca(2+) or Mg(2+). Only soluble K(+) increased, due to the K(+) supplied by the amendments. The cation exchange capacity increased in treated soils, the exchange complex being mainly saturated with Ca(2+), Mg(2+) and K(+). However, Na(+) was not retained in the exchange sites, and the sodium absorption ratio remained low. The compost and manure increased markedly the shoot growth of the salt-tolerant Beta maritima L. (sea beet) and Beta vulgaris L. (sugar beet). For B. maritima, this seemed to be related to decreases in the shoot concentrations of Na(+) and Cl(-) and increases in K(+) and H(2)PO(4)(-). In the case of B. vulgaris, increases in shoot H(2)PO(4)(-) and B and, for manure-treated soil, a decrease in shoot Na(+) may have been involved. Cultivation of tomato (Lycopersicon esculentum Mill. cv. Moneymaker) in the soil used previously for B. vulgaris indicated that the effects of the manure on tissue cation concentrations were longer-lasting than those of the compost.

  9. High Iron Requirement for Growth, Photosynthesis, and Low-light Acclimation in the Marine Cyanobacterium Synechococcus bacillaris

    Science.gov (United States)

    Sunda, W. G.; Huntsman, S. A.

    2016-02-01

    Iron is a critical nutrient in photosynthesis and limits phytoplankton growth in large regions of the ocean. Most of the iron in phytoplankton occurs in iron-containing proteins in the photosynthetic apparatus, and thus interactions among cellular iron, light, and growth rate are predicted. In agreement with this prediction, decreasing light intensity increased the cellular iron:carbon (Fe:C) ratio needed to support a given growth rate by 2- to 3-fold in both a coastal diatom Thalassiosira pseudonana, and a coastal cyanobacterium Synechococcus bacillaris due to an increase in iron-containing photosynthetic units. However, although the light responses were similar, the cellular Fe:C ratios needed to support a given growth rate were 5- to 8-fold higher in the cyanobacterium than in the diatom, a pattern seen in other Syechococcus isolates and eukaryotic phytoplankton. Due to the high iron requirement for growth and low light acclimation, we might expect Synechococcus to be at a competitive disadvantage in many low-iron and low-light environments. Indeed, it decreases rapidly with depth within the ocean's deep chlorophyll maximum (DCM), where iron and light levels are low and lower-iron requiring eukaryotic algae typically dominate the phytoplankton biomass in the mid to lower DCM.

  10. A Task Management System with High Availability for High-Throughput Material Simulation%一个高可用的高通量材料计算任务管理系统

    Institute of Scientific and Technical Information of China (English)

    刘一骏; 杨小渝; 任杰; 王宗国

    2015-01-01

    我们设计与实现了一种高可用的高通量第一性原理材料计算任务管理系统。该系统支持第一性原理计算任务的自动化流程管理,包括计算任务动态管理、状态监控、容错、纠错处理等功能。尤其是实现了计算任务在自动流程中计算出错的情况下的纠错处理,能够有效的提高任务的成功率与高通量计算平台的可用性。在整个过程中不需要人工干预,实现整个计算自动流程化。该系统在结构推演的测试案例中进行了测试,如当能量不收敛时,能够自动调整相关计算参数,使能量计算能够收敛,取得了预期的效果。%A task management system with high availability for high-throughput ifrst-principle material calculation is designed and implemented. The system can automate the process for first-principle calculations, including dynamic task scheduling, status monitoring, fault tolerance, and error correction, etc. Especially, calculation-related errors that occur during the simulation can be captured and handled automatically without direct human control. This can effectively improve the success rate of simulation jobs hence improve the availability of the platform. The system is tested in the applications of structure derivation, and it has been demonstrated that the system works effectively. For example, once the energy calculation is not converged, relevant calculation parameters can automatically be adjusted till the energy is converged.

  11. Technical training - places available

    CERN Multimedia

    2012-01-01

    If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch Valeria Perez Reale, Learning Specialist, Technical Programme Coordinator (Tel.: 62424) Eva Stern and Elise Romero, Technical Training Administration (Tel.: 74924) HR Department »Electronics design Next Session Duration Language Availability Comprehensive VHDL for FPGA Design 08-Oct-12 to 12-Oct-12 5 days English 3 places available Foundations of Electromagnetism and Magnet Design (EMAG) 14-Nov-12 to 27-Nov-12 6 days English 20 places available Impacts de la suppression du plomb (RoHS) en électronique 26-Oct-12 to 26-Oct-12 8 hours French 15 places available Introduction to VHDL 10-Oct-12 to 11-Oct-12 2 days English 7 places available LabVIEW Real Time and FPGA 13-Nov-12 to 16-Nov-12 5 days French 5 places available »Mechanical design Next Se...

  12. Quality Control of Biomedicinal Allergen Products - Highly Complex Isoallergen Composition Challenges Standard MS Database Search and Requires Manual Data Analyses.

    Science.gov (United States)

    Spiric, Jelena; Engin, Anna M; Karas, Michael; Reuter, Andreas

    2015-01-01

    Allergy against birch pollen is among the most common causes of spring pollinosis in Europe and is diagnosed and treated using extracts from natural sources. Quality control is crucial for safe and effective diagnosis and treatment. However, current methods are very difficult to standardize and do not address individual allergen or isoallergen composition. MS provides information regarding selected proteins or the entire proteome and could overcome the aforementioned limitations. We studied the proteome of birch pollen, focusing on allergens and isoallergens, to clarify which of the 93 published sequence variants of the major allergen, Bet v 1, are expressed as proteins within one source material in parallel. The unexpectedly complex Bet v 1 isoallergen composition required manual data interpretation and a specific design of databases, as current database search engines fail to unambiguously assign spectra to highly homologous, partially identical proteins. We identified 47 non-allergenic proteins and all 5 known birch pollen allergens, and unambiguously proved the existence of 18 Bet v 1 isoallergens and variants by manual data analysis. This highly complex isoallergen composition raises questions whether isoallergens can be ignored or must be included for the quality control of allergen products, and which data analysis strategies are to be applied.

  13. Available Energy and Exergy

    Directory of Open Access Journals (Sweden)

    Richard A. Gaggioli

    1998-06-01

    Full Text Available

    An "available energy" is defined for every state of any system. The definition is independent of (a the concept of work. (b any reference environment, and (c the makeup of the system (e.g. "macro" or "micro. On the basis of this available energy, given any composite system, the contribution of each subsystem to the available energy -- that is, the exergy content of a subsystem -- is defined, as well as the instantaneous "dead state" of the composite and each subsystem.

    Some pedagogical, scientific and engineering implications are discussed.

  14. High-dose aspirin is required to influence plasma fibrin network structure in patients with type 1 diabetes.

    Science.gov (United States)

    Tehrani, Sara; Antovic, Aleksandra; Mobarrez, Fariborz; Mageed, Koteiba; Lins, Per-Eric; Adamson, Ulf; Wallén, Håkan N; Jörneskog, Gun

    2012-02-01

    Patients with type 1 diabetes form a less permeable fibrin network, which could contribute to their increased risk of cardiovascular disease (CVD). Low-dose aspirin treatment is the standard in the management of CVD; however, the effect seems reduced in patients with diabetes. We investigated the effects of low- and high-dose aspirin treatment on fibrin network formation in patients with type 1 diabetes (primary aim) and the possible interaction between the treatment effects of aspirin on fibrin network permeability and glycemic control in these patients (secondary aim). Forty-eight patients (24 subjects with good [HbA(1c) 8.4%] glycemic control) were randomly assigned to treatment with 75 or 320 mg/day aspirin during 4 weeks in a crossover fashion. A 4-week washout period separated the treatment periods. The plasma fibrin network was assessed by determination of the permeability coefficient (K(s)). Treatment with 75 mg aspirin did not influence fibrin network permeability (K(s)). However, K(s) increased significantly during treatment with 320 mg aspirin (P = 0.004), and a significant treatment effect was seen compared with treatment with 75 mg aspirin (P = 0.009). The increase in K(s) during high-dose aspirin treatment was significant in patients with poor glycemic control (P = 0.02), whereas K(s) only tended to increase in patients with good glycemic control (P = 0.06). A high dose of aspirin is required to influence fibrin network permeability in patients with type 1 diabetes. The observed lack of effect with low-dose aspirin may contribute to aspirin treatment failure in diabetes.

  15. Psychiatric emergency "surge capacity" following acts of terrorism and mass violence with high media impact: what is required?

    Science.gov (United States)

    Claassen, Cindy; Kashner, T Michael; Kashner, Tetyana K; Xuan, Lei; Larkin, Gregory L

    2011-01-01

    Adequate preparedness for acts of terrorism and mass violence requires a thorough understanding of the postdisaster mental health needs of all exposed groups, including those watching such events from a distance. This study examined emergency psychiatric treatment-seeking patterns following media exposure to four national terrorist or mass casualty events. An event was selected for study if (a) it precipitated local front-page headlines for >5 consecutive days and (b) emergency service psychiatrists identified it as specifically precipitating help-seeking in the study hospital. Four events qualified: the Oklahoma City bombing (1995), the Columbine High School (1999) and Wedgewood Baptist Church (1999) shootings and the terrorist attacks of September 11, 2001. Time-series analyses were used to correct for autocorrelation in visit patterns during the postdisaster week, and equivalent time periods from years before and after each event were used as control years. Overall, disaster week census did not differ significantly from predisaster weeks, although 3-day nonsignificant decreases in visit rate were observed following each disaster. Treatment-seeking for anxiety-related issues showed a nonsignificant increase following each disaster, which became significant in the "all disaster" model (t=5.17; P=.006). Intensity of media coverage did not impact rate of help-seeking in any analysis. Although these sentinel US disasters varied in scope, method, geographic proximity to the study site, perpetrator characteristics, public response, sequelae and degree of media coverage, the extent to which they impacted emergency department treatment-seeking was minimal. Geographically distant mass violence and disaster events of the type and scope studied here may require only minimal mental health "surge capacity" in the days following the event. Copyright © 2011 Elsevier Inc. All rights reserved.

  16. Available area isotherm

    NARCIS (Netherlands)

    Bosma, JC; Wesselingh, JA

    2004-01-01

    A new isotherm is presented for adsorption of proteins, the available area isotherm. This isotherm has a steric basis, unlike the (steric) mass action model. The shape of the available area isotherm is determined only by geometric exclusion. With the new isotherm, experimental results can be fitted

  17. Technical training - Places available

    CERN Multimedia

    2012-01-01

    If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch Valeria Perez Reale, Learning Specialist, Technical Programme Coordinator (Tel.: 62424) Eva Stern and Elise Romero, Technical Training Administration (Tel.: 74924)   Electronics design Next Session Duration Language Availability Certified LabVIEW Associate Developer (CLAD) 06-Dec-12 to 06-Dec-12 1 hour English One more place available Compatibilité électromagnetique (CEM): Applications 23-Nov-12 to 23-Nov-12 3.5 hours English 3 places available Compatibilité électromagnétique (CEM): Introduction 23-Nov-12 to 23-Nov-12 3 hours English 43 places available Effets des Radiations sur les composants et systèmes électroniques 11-Dec-12 to 12-Dec-12 1 day 4 hours French 9 places available LabVIEW for beginners ...

  18. Analysis of Multi-Stakeholder Requirements Using Requirement Interaction Matrix

    Directory of Open Access Journals (Sweden)

    Rohayanti Hassan

    2017-09-01

    Full Text Available Software requirements engineering is an imperative phase in the software development life cycle in every project regardless of the project size. In a project, different people are involved in the requirements engineering process, including requirement engineers, stakeholders, end users, and system designers. Amongst them, stakeholders play an essential role. Differences in goals and priorities of multiple stakeholders would make requirements management complex and difficult, which is a huge challenge for requirement engineers. From time to time, new requirements emerge and existing requirements need changes to fulfil stakeholders’ goals. Thus, such situation leads to high requirements volatility and low stability which causes overlapping and conflicting of requirements. The correctness and validity of requirements are of paramount importance as they are the key factors toward a successful system. A deep understanding of requirement management technique that conforms to users’ needs is crucial. Such technique of the concept is applied to the Labour Management System. In this study, we have discussed the implementation of analysis of multi-stakeholder requirements using requirement interaction matrix in the f. The study used real requirements to yield a solid and dependable result. We have documented the requirements using a template and assessed their respective volatility level. An algorithm is constructed to   show   that   the   technique has managed to minimize   the time   used   when   checking requirements.

  19. Technical training: places available

    CERN Multimedia

    HR Department

    2007-01-01

    CERN Technical Training: Open Courses (April - June 2007) The following course sessions are currently scheduled in the framework of the CERN Technical Training Programme 2007:   AutoCAD 2006 - niveau 1 (course in French): 25.4.- 26.4.2007 & 2.5. - 3.5.2007 (4 days in 2 modules, 5 places available) AutoCAD 2006 - niveau 1 (course in French): 27.6.- 28.6.2007 & 3.7. - 4.7.2007 (4 days in 2 modules, 5 places available) AutoCAD Mechanical 2006 (course in French) 21.6.-22.6.2007 (2 days, 8 places available) * NEW COURSE* Automate de securite S7 (course in French) 14.5.-16.5.2007 (3 days, 4 places available) * NEW COURSE* Automate de securite S7 (course in French): 9.5.-11.5.2007 (3 days, 4 places available) JCOP - Joint PVSS-JCOP Frameswork (course in English): 21.5.-25.5.2007 (5 days, 12 places available) JCOP - Finite State Machines in the JCOP Frameswork (course in English): 12.6.-14.6.2007 (3 days, 12 places available) LabVIEW Basics 1 (in English): 2.-4.5.2007 (3 days, 7 places ...

  20. Technical Training: Places available

    CERN Multimedia

    Monique Duval

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: The Joint PVSS JCOP Framework: 14 - 18.6.2004 (5 days) EXCEL 2003 - niveau 2 : 17 & 18.6.2004 (2 jours) MAGNE-04 : Magnétisme pour l'électrotechnique : 6 au 8.7.2004 (3 jours) Technical Training Monique Duval - Tel.74924 technical.training@cern.ch