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Sample records for high alpha conference

  1. Conference on High Energy Physics

    CERN Document Server

    2016-01-01

    Conference on High Energy Physics (HEP 2016) will be held from August 24 to 26, 2016 in Xi'an, China. This Conference will cover issues on High Energy Physics. It dedicates to creating a stage for exchanging the latest research results and sharing the advanced research methods. HEP 2016 will be an important platform for inspiring international and interdisciplinary exchange at the forefront of High Energy Physics. The Conference will bring together researchers, engineers, technicians and academicians from all over the world, and we cordially invite you to take this opportunity to join us for academic exchange and visit the ancient city of Xi’an.

  2. Hypothalamic PGC-1 alpha Protects Against High-Fat Diet Exposure by Regulating ER alpha

    NARCIS (Netherlands)

    Morselli, Eugenia; Fuente-Martin, Esther; Finan, Brian; Kim, Min; Frank, Aaron; Garcia-Caceres, Cristina; Navas, Carlos Rodriguez; Gordillo, Ruth; Neinast, Michael; Kalainayakan, Sarada P.; Li, Dan L.; Gao, Yuanqing; Yi, Chun-Xia; Hahner, Lisa; Palmer, Biff F.; Tschöp, Matthias H.; Clegg, Deborah J.

    2014-01-01

    High-fat diets (HFDs) lead to obesity and inflammation in the central nervous system (CNS). Estrogens and estrogen receptor alpha (ER alpha) protect premenopausal females from the metabolic complications of inflammation and obesity-related disease. Here, we demonstrate that hypothalamic PGC-1 alpha

  3. High collection efficiency CVD diamond alpha detectors

    International Nuclear Information System (INIS)

    Bergonzo, P.; Foulon, F.; Marshall, R.D.; Jany, C.; Brambilla, A.; McKeag, R.D.; Jackman, R.B.

    1998-01-01

    Advances in Chemical Vapor Deposited (CVD) diamond have enabled the routine use of this material for sensor device fabrication, allowing exploitation of its unique combination of physical properties (low temperature susceptibility (> 500 C), high resistance to radiation damage (> 100 Mrad) and to corrosive media). A consequence of CVD diamond growth on silicon is the formation of polycrystalline films which has a profound influence on the physical and electronic properties with respect to those measured on monocrystalline diamond. The authors report the optimization of physical and geometrical device parameters for radiation detection in the counting mode. Sandwich and co-planar electrode geometries are tested and their performances evaluated with regard to the nature of the field profile and drift distances inherent in such devices. The carrier drift length before trapping was measured under alpha particles and values as high as 40% of the overall film thickness are reported. Further, by optimizing the device geometry, they show that a gain in collection efficiency, defined as the induced charge divided by the deposited charge within the material, can be achieved even though lower bias values are used

  4. Aspen Winter Conferences on High Energy

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2011-02-12

    The 2011 Aspen Winter Conference on Particle Physics was held at the Aspen Center for Physics from February 12 to February 18, 2011. Ninety-four participants from ten countries, and several universities and national labs attended the workshop titled, "New Data From the Energy Frontier." There were 54 formal talks, and a considerable number of informal discussions held during the week. The week's events included a public lecture ("The Hunt for the Elusive Higgs Boson" given by Ben Kilminster from Ohio State University) and attended by 119 members of the public, and a physics cafe geared for high schoolers that is a discussion with physicists. The 2011 Aspen Winter Conference on Astroparticle physics held at the Aspen Center for Physics was "Indirect and Direct Detection of Dark Matter." It was held from February 6 to February 12, 2011. The 70 participants came from 7 countries and attended 53 talks over five days. Late mornings through the afternoon are reserved for informal discussions. In feedback received from participants, it is often these unplanned chats that produce the most excitement due to working through problems with fellow physicists from other institutions and countries or due to incipient collaborations. In addition, Blas Cabrera of Stanford University gave a public lecture titled "What Makes Up Dark Matter." There were 183 members of the general public in attendance. Before the lecture, 45 people attended the physics cafe to discuss dark matter. This report provides the attendee lists, programs, and announcement posters for each event.

  5. Anti-pp,. cap alpha cap alpha. and p. cap alpha. elastic scattering at high energies and Chou-Yang conjecture

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Fazal-e-Aleem; Rifique, M.

    1987-03-01

    The recent experimental measurements for anti-pp and ..cap alpha cap alpha.. elastic scattering at high energies have shown that the Chou-Yang conjecture regarding the relationship between the electromagnetic and the hadronic form factor of a particle is only an approximation. A new ansatz has been proposed to obtain hadronic form factors of proton and the ..cap alpha..-particle. These form factors have been used to explain the various characteristics of anti-pp, ..cap alpha cap alpha.. and p..cap alpha.. elastic scattering at high energies.

  6. Proceedings, High-Precision $\\alpha_s$ Measurements from LHC to FCC-ee

    Energy Technology Data Exchange (ETDEWEB)

    d' Enterria, David [CERN; Skands, Peter Z. [Monash U.

    2015-01-01

    This document provides a writeup of all contributions to the workshop on "High precision measurements of $\\alpha_s$: From LHC to FCC-ee" held at CERN, Oct. 12--13, 2015. The workshop explored in depth the latest developments on the determination of the QCD coupling $\\alpha_s$ from 15 methods where high precision measurements are (or will be) available. Those include low-energy observables: (i) lattice QCD, (ii) pion decay factor, (iii) quarkonia and (iv) $\\tau$ decays, (v) soft parton-to-hadron fragmentation functions, as well as high-energy observables: (vi) global fits of parton distribution functions, (vii) hard parton-to-hadron fragmentation functions, (viii) jets in $e^\\pm$p DIS and $\\gamma$-p photoproduction, (ix) photon structure function in $\\gamma$-$\\gamma$, (x) event shapes and (xi) jet cross sections in $e^+e^-$ collisions, (xii) W boson and (xiii) Z boson decays, and (xiv) jets and (xv) top-quark cross sections in proton-(anti)proton collisions. The current status of the theoretical and experimental uncertainties associated to each extraction method, the improvements expected from LHC data in the coming years, and future perspectives achievable in $e^+e^-$ collisions at the Future Circular Collider (FCC-ee) with $\\cal{O}$(1--100 ab$^{-1}$) integrated luminosities yielding 10$^{12}$ Z bosons and jets, and 10$^{8}$ W bosons and $\\tau$ leptons, are thoroughly reviewed. The current uncertainty of the (preliminary) 2015 strong coupling world-average value, $\\alpha_s(m_Z)$ = 0.1177 $\\pm$ 0.0013, is about 1\\%. Some participants believed this may be reduced by a factor of three in the near future by including novel high-precision observables, although this opinion was not universally shared. At the FCC-ee facility, a factor of ten reduction in the $\\alpha_s$ uncertainty should be possible, mostly thanks to the huge Z and W data samples available.

  7. Analysis of cadmium in high alpha solutions

    International Nuclear Information System (INIS)

    Gray, L.W.; Overman, L.A.; Hodgens, H.F.

    1977-07-01

    Cadmium nitrate is occasionally used as a neutron poison for convenience in the separation of uranium, neptunium, and plutonium. As the classical methods of analysis for cadmium are very time-consuming, a method to isolate it in solution using solvent extraction of uranium, neptunium, and plutonium with TBP in an n-paraffin hydrocarbon was investigated. After removal of the radionuclides, the cadmium is determined by atomic absorption spectroscopy. Precision of the method at the 95 percent confidence level is +-2.4 percent. Alpha content of the solutions was typically reduced from 1-10 x 10 11 dis/(min ml) 238 Pu to 1-15 x 10 4 dis/(min ml). Analysis time was typically reduced from approximately 24 hours per sample to less than 1 hour

  8. Conference summary on new trends in high-energy physics

    International Nuclear Information System (INIS)

    Terazawa, H.

    2001-01-01

    Concluding remarks on over forty papers contributed to the International Conference on New Trends in High-Energy Physics, Yalta, Crimea, Ukraine, September 22 - 29, 2001 are presented. Also presented are some comments on future prospects in high energy physics

  9. Lithium abundances in high- and low-alpha halo stars

    DEFF Research Database (Denmark)

    Nissen, P. E.; Schuster, W. J.

    2012-01-01

    A previous study of F and G main-sequence stars in the solar neighborhood has revealed the existence of two distinct halo populations with a clear separation in [alpha /Fe] for the metallicity range -1.4 < [Fe/H] < -0.7. The kinematics of the stars and models of galaxy formation suggest that the ......A previous study of F and G main-sequence stars in the solar neighborhood has revealed the existence of two distinct halo populations with a clear separation in [alpha /Fe] for the metallicity range -1.4 ... that the ``high-alpha '' stars were formed in situ in the inner parts of the Galaxy, whereas the ``low-alpha '' ones have been accreted from satellite galaxies. In order to see if there is any systematic difference in the lithium abundances of high- and low-alpha stars, equivalent widths of the iLi 6707.8 Å line...... have been measured from VLT/UVES and NOT/FIES spectra and used to derive Li abundances. Furthermore, stellar masses are determined from evolutionary tracks in the log T_eff - log g diagram. For stars with masses 0.7 lithium abundance...

  10. Second topical conference on high-temperature plasma diagnostics

    International Nuclear Information System (INIS)

    Jahoda, F.C.; Freese, K.B.

    1978-02-01

    This report contains the program and abstracts of papers presented at the Second American Physical Society Topical Conference on High Temperature Plasma Diagnostics, March 1-3, 1978, Santa Fe, New Mexico

  11. Second international Israeli conference on High Tc Superconductivity

    International Nuclear Information System (INIS)

    1993-01-01

    The superconductivity fields covered in this conference are: theory, applications, devices, flux properties high frequencies, Josephson junctions, magnetism, material sciences and physical properties of superconductors, spectroscopy and resonances and thin films

  12. Fifth International Conference on High Energy Density Physics

    Energy Technology Data Exchange (ETDEWEB)

    Beg, Farhat

    2017-07-05

    The Fifth International Conference on High Energy Density Physics (ICHED 2015) was held in the Catamaran Hotel in San Diego from August 23-27, 2015. This meeting was the fifth in a series which began in 2008 in conjunction with the April meeting of the American Physical Society (APS). The main goal of this conference has been to bring together researchers from all fields of High Energy Density Science (HEDS) into one, unified meeting.

  13. Acute toxicity of high doses of the glycoalkaloids, alpha-solanine and alpha-chaconine, in the Syrian Golden hamster

    DEFF Research Database (Denmark)

    Langkilde, Søren; Schrøder, Malene; Stewart, Derek

    2008-01-01

    Sprouted, stressed, or spoiled potato tubers have reportedly led to human acute intoxication, coma, and death when consumed in high amounts. These effects have been attributed to glycoalkaloids (GAs), primarily alpha-solanine and alpha-chaconine, naturally present in all potatoes. The level of GAs...

  14. 14th High-Tech Plasma Processes Conference (HTPP 14)

    Science.gov (United States)

    2017-04-01

    Preface The High-Tech Plasma Processes Conference (HTPP) is a bi-annual international conference based in Europe with topics encompassing the whole area of plasma processing science. This conference is open to all the international community in the world involved in plasma science and plasma technology. The aim of the conference is to bring different scientific communities together, facilitate the contacts between science, technology and industry and provide a platform for the exploration of both fundamental topics and new applications of plasmas. For this edition of HTPP, as was the case for the last, we have achieved a well balanced participation from the communities of both thermal and non-thermal plasma researchers. 75 people from 17 countries attended the conference with the total number of contributions being 74, consisting of 19 invited talks and 55 poster contributions. As a HTPP tradition a poster competition has been carried out during the conference. The winner of the poster competition was Fabrice Mavier from Université de Limoges, France with his paper “Pulsed arc plasma jet synchronized with drop-on-demand dispenser” All the participants also ejoyed the social program including an “unconventional” tour of the city, the visit to the famous Hofbräuhaus and the dinner at the Blutenburg, a beautiful inner-city castle. We have received papers corresponding to the contributions of HTPP-2014 that have been submitted for publication in this volume of Journal of Physics: Conference Series. Each submitted contribution has been peer reviewed and the Editors are very grateful to the referees for their careful support in improving the original manuscripts. In total, 18 manuscripts have been accepted for publication covering a range of topics of plasma processing science from plasma fundamentals to process applications through to experiments, diagnostics and modelling. We deeply thank the authors for their enthusiastic and high-grade contributions and we

  15. The European Physical Society Conference on High Energy Physics

    Science.gov (United States)

    2017-07-01

    The European Physical Society Conference on High Energy Physics (EPS- HEP) is one of the major international conferences that review the field. It takes place every other year since 1971. It is organized by the High Energy and Particle Physics Division of the European Physical Society in cooperation with an appointed European Local Institute of Research or an internationally recognized University or Academy Body. EPS-HEP 2017 was held on 5-12 July in Venice, Italy at Palazzo del Cinema and Palazzo del Casinò, located in the Lido island. The conference has been organized by the Istituto Nazionale di Fisica Nucleare (INFN) and by the Department of Physics and Astronomy of the University of Padova. Editorial Board: Paolo Checchia, Mauro Mezzetto, Giuseppina Salente, Michele Doro, Livia Conti, Caterina Braggio, Chiara Sirignano, Andrea Dainese, Martino Margoni, Roberto Rossin, Pierpaolo Mastrolia, Patrizia Azzi, Enrico Conti, Marco Zanetti, Luca Martucci, Sofia Talas Lucano Canton.

  16. Conference on High Performance Software for Nonlinear Optimization

    CERN Document Server

    Murli, Almerico; Pardalos, Panos; Toraldo, Gerardo

    1998-01-01

    This book contains a selection of papers presented at the conference on High Performance Software for Nonlinear Optimization (HPSN097) which was held in Ischia, Italy, in June 1997. The rapid progress of computer technologies, including new parallel architec­ tures, has stimulated a large amount of research devoted to building software environments and defining algorithms able to fully exploit this new computa­ tional power. In some sense, numerical analysis has to conform itself to the new tools. The impact of parallel computing in nonlinear optimization, which had a slow start at the beginning, seems now to increase at a fast rate, and it is reasonable to expect an even greater acceleration in the future. As with the first HPSNO conference, the goal of the HPSN097 conference was to supply a broad overview of the more recent developments and trends in nonlinear optimization, emphasizing the algorithmic and high performance software aspects. Bringing together new computational methodologies with theoretical...

  17. 35th International Conference of High Energy Physics

    Science.gov (United States)

    The French particle physics community is particularly proud to have been selected to host the 35th ICHEP conference in 2010 in Paris. This conference is the focal point of all our field since more than fifty years and is the reference event where all important results in particle physics cosmology and astroparticles are presented and discussed. This alone suffices to make this event very important. But in 2010, a coincidence of exceptional events will make this conference even more attractive! What is then so special about ICHEP 2010 conference? It will be the first ICHEP conference where physics results obtained at the LHC will be presented! New results about the elusive Higgs boson, or signals of physics beyond the standard model might therefore be announced at this conference! Major discoveries in other domains such as gravitational waves, neutrino telescopes, neutrino oscillations, dark matter or in the flavour sector are also possible, just to name a few. In addition , 2010 will be an important date to shape up the future of our field. Several major projects will present the status of their Conceptual or Engineering Design Reports during the conference. The International Linear Collider (ILC) Global Design Effort team will present the report corresponding to the end of their Technical Design Phase 1. The Compact Linear Collider (CLIC) will also report on its Conceptual Design Report. Other major projects such as Super B factories will also be presented. These reports together with LHC physics results will form the basis for key political decisions needed to be taken in the years to come. In summary, there can be no doubt that Paris is the place to be in summer 2010 for anyone interested in High Energy Physics and we will make every effort to make your stay as interesting and enjoyable as possible.

  18. Determination of radium-226 by high-resolution alpha spectrometry

    International Nuclear Information System (INIS)

    Sill, C.W.

    1983-01-01

    The determination of radium-226 by alpha spectrometry has been investigated critically to determine experimental conditions under which high resolution and accurate and reliable results can be obtained. Refractory solids such as soils, ores, and tailings from uranium mills are dissolved completely by fusion with potassium fluoride in the presence of barium-133 tracer. The fluoride cake is then transposed with sulfuric acid to a pyrosulfate fusion with simultaneous volatilization of all silica and fluoride. Radium is precipitated with barium already present in the sample by addition of lead perchlorate to a dilute hydrochloric acid solution of the pyrosulfate cake. The resulting insoluble sulfates are dissolved in an alkaline solution of diethylenetriaminepentaacetic acid, and the radium and barium sulfates are reprecipitated with acetic acid. The precipitate is mounted on a membrane filter and analyzed by alpha spectrometry. Water samples are partially evaporated and treated similarly. Resolution of the subsequent alpha spectra is much better than has been achieved previously from barium sulfate, and is almost as good as is obtainable with actinides electrodeposited on polished steel plates. The resolution is about 60 keV full-width-half-maximum with 100 μg of barium on a 1-inch filter with a 450 mm 2 detector at 20% counting efficiency. Recovery is about 97% and accuracy is generally as good as the counting statistics obtained will permit. Grossly inaccurate results can be obtained under certain conditions when barium-133 tracer is used to determine the chemical yield of radium-226. Severe contamination of the surface-barrier detector by polonium-210 and by recoil products of the radium isotopes being counted is demonstrated, amd methods for virtual elimination of both problems are discussed

  19. International Conference on Spectral and High-Order Methods

    CERN Document Server

    Dumont, Ney; Hesthaven, Jan

    2017-01-01

    This book features a selection of high-quality papers chosen from the best presentations at the International Conference on Spectral and High-Order Methods (2016), offering an overview of the depth and breadth of the activities within this important research area. The carefully reviewed papers provide a snapshot of the state of the art, while the extensive bibliography helps initiate new research directions.

  20. Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice

    Directory of Open Access Journals (Sweden)

    Takeya Motohiro

    2010-04-01

    Full Text Available Abstract Background Various factors impact the severity of malaria, including the nutritional status of the host. Vitamin E, an intra and extracellular anti-oxidant, is one such nutrient whose absence was shown previously to negatively affect Plasmodium development. However, mechanisms of this Plasmodium inhibition, in addition to means by which to exploit this finding as a therapeutic strategy, remain unclear. Methods α-TTP knockout mice were infected with Plasmodium berghei NK65 or Plasmodium yoelii XL-17, parasitaemia, survival rate were monitored. In one part of the experiments mice were fed with a supplemented diet of vitamin E and then infected. In addition, parasite DNA damage was monitored by means of comet assay and 8-OHdG test. Moreover, infected mice were treated with chloroquine and parasitaemia and survival rate were monitored. Results Inhibition of α-tocopherol transfer protein (α-TTP, a determinant of vitamin E concentration in circulation, confers resistance to malarial infection as a result of oxidative damage to the parasites. Furthermore, in combination with the anti-malarial drug chloroquine results were even more dramatic. Conclusion Considering that these knockout mice lack observable negative impacts typical of vitamin E deficiency, these results suggest that inhibition of α-TTP activity in the liver may be a useful strategy in the prevention and treatment of malaria infection. Moreover, a combined strategy of α-TTP inhibition and chloroquine treatment might be effective against drug resistant parasites.

  1. PREFACE: The EPS High Energy Particle Physics Conference

    Science.gov (United States)

    Barlow, Roger

    2008-03-01

    HEPP2007, the EPS High Energy Particle Physics Conference, was held in Manchester from July 19-26 2007. It brought together 580 delegates across the whole subject: from string theorists to detector technologists, from young postgraduate students to senior professors. Geographically they came from the UK, from the rest of Europe, from North America, and from the rest of the world. It covered the whole spectrum of the subject, not only accelerator-based experiments but also its astrophysical and cosmological aspects. The parallel and plenary talks can be found in these proceedings. A key feature of the conference, as always, was the award of the prizes: this year the EPS prize was awarded to Makoto Kobayashi and Toshihide Maskawa for their explanation of CP violation with a 6 quark model—Kobayashi came to accept it in person. The Gribov medal went to Niklas Beisert, the outreach prize to Richard Jacobsson and Charles Timmermans and the Young Physicist prizer to I Furic, G Gomez-Ceballos and S Menzemer. Parallel sessions were held in Manchester University, and plenary talks were held in the Bridgewater Hall in Manchester Town centre, a magnificent modern venue whose positive and co-operative staff enabled the conference to make the most of the impressive surroundings. We were able to put the hall to its proper purpose one evening with a concert by the Fairey Band—one of the distinctive brass bands who form part of the rich musical tradition of the North of England, and came as something new and different to many of the delegates. The conference ran smoothly and successfully, thanks largely to hard work by the local organising committee who devoted a lot of time to planning, producing ideas, and anticipating potential problems. Many of them were not from Manchester itself but from other universities and laboratories in the North of England, so their dedication was especially appreciated. The EPS committee also played a major part, by the selection of plenary

  2. High-resolution Lyman-alpha filtergrams of the sun

    Science.gov (United States)

    Bonnet, R. M.; Decaudin, M.; Bruner, E. C., Jr.; Acton, L. W.; Brown, W. A.

    1980-01-01

    The results of an experiment, conducted jointly by the Lockheed Palo Alto Research Laboratory and the Laboratoire de Physique Stellaire et Planetaire du CNRS, which investigated the transition-region plasma and the geometry of coronal active regions, in relation to models of the high-temperature layers, are presented. A Black Brant rocket was used to obtain 1-arc sec resolution L-alpha pictures of the sun, which revealed small scale features not seen previously at this wavelength, that delineate the geometry of the magnetic field in the chromosphere and in the corona. It is concluded that these observations might provide a new way of observing the upper chromosphere and corona, and that they provide direct evidence of the inhomogeneous character of the chromosphere and of the dominant role of the magnetic field

  3. PREFACE: The International Conference on Highly Frustrated Magnetism HFM2008

    Science.gov (United States)

    Eremin, Ilya; Brenig, Wolfram; Kremer, Reinhard; Litterst, Jochen

    2009-01-01

    The International Conference on Highly Frustrated Magnetism 2008 (HFM2008) took place on 7-12 September 2008 at the Technische Universität Carolo-Wilhelmina zu Braunschweig, Germany. This conference was the fourth event in a series of meetings, which started in Waterloo, Canada (HFM 2000), followed by the second one in Grenoble, France (HFM 2003), and the third meeting in Osaka, Japan (HFM 2006). HFM2008 attracted more than 220 participants from all over the world. The number of participants of the HFM conference series has been increasing steadily, from about 80 participants at HFM 2000, to 120 participants at HFM 2003, and 190 participants at HFM 2006, demonstrating that highly frustrated magnetism remains a rapidly growing area of research in condensed matter physics. At the end of HFM2008 it was decided that the next International Conference on Highly Frustrated Magnetism will be held in Baltimore, USA in 2010. HFM2008 saw four plenary talks by R Moessner, S Nakatsuji, S-W Cheong, and S Sachdev, 18 invited presentations, 30 contributed talks and about 160 poster presentations from all areas of frustrated magnetism. The subjects covered by the conference included: Kagome systems Itinerant frustrated systems Spinels and pyrochlore materials Triangular systems Unconventional order and spin liquids Chain systems Chain systems Novel frustrated systems This volume of Journal of Physics: Conference Series contains the proceedings of HFM2008 with 83 papers that provide a scientific record of the scientific topics covered by the conference. All articles have been refereed by experts in the field. It is our hope that the reader will enjoy and profit from the HFM2008 Proceedings. Ilya Eremin Proceedings Editor Wolfram Brenig, Reinhard Kremer, and Jochen Litterst Co-Editors International Advisory Board L Balents (USA) F Becca (Italy) S Bramwell (UK) P Fulde (Germany) B D Gaulin (Canada) J E Greedan (Canada) A Harrison (France) Z Hiroi (Japan) H Kawamura (Japan) A Keren

  4. 3rd International Conference on High Performance Scientific Computing

    CERN Document Server

    Kostina, Ekaterina; Phu, Hoang; Rannacher, Rolf

    2008-01-01

    This proceedings volume contains a selection of papers presented at the Third International Conference on High Performance Scientific Computing held at the Hanoi Institute of Mathematics, Vietnamese Academy of Science and Technology (VAST), March 6-10, 2006. The conference has been organized by the Hanoi Institute of Mathematics, Interdisciplinary Center for Scientific Computing (IWR), Heidelberg, and its International PhD Program ``Complex Processes: Modeling, Simulation and Optimization'', and Ho Chi Minh City University of Technology. The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and applications in practice. Subjects covered are mathematical modelling, numerical simulation, methods for optimization and control, parallel computing, software development, applications of scientific computing in physics, chemistry, biology and mechanics, environmental and hydrology problems, transport, logistics and site loca...

  5. 5th International Conference on High Performance Scientific Computing

    CERN Document Server

    Hoang, Xuan; Rannacher, Rolf; Schlöder, Johannes

    2014-01-01

    This proceedings volume gathers a selection of papers presented at the Fifth International Conference on High Performance Scientific Computing, which took place in Hanoi on March 5-9, 2012. The conference was organized by the Institute of Mathematics of the Vietnam Academy of Science and Technology (VAST), the Interdisciplinary Center for Scientific Computing (IWR) of Heidelberg University, Ho Chi Minh City University of Technology, and the Vietnam Institute for Advanced Study in Mathematics. The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and practical applications. Subjects covered include mathematical modeling; numerical simulation; methods for optimization and control; parallel computing; software development; and applications of scientific computing in physics, mechanics and biomechanics, material science, hydrology, chemistry, biology, biotechnology, medicine, sports, psychology, transport, logistics, com...

  6. 6th International Conference on High Performance Scientific Computing

    CERN Document Server

    Phu, Hoang; Rannacher, Rolf; Schlöder, Johannes

    2017-01-01

    This proceedings volume highlights a selection of papers presented at the Sixth International Conference on High Performance Scientific Computing, which took place in Hanoi, Vietnam on March 16-20, 2015. The conference was jointly organized by the Heidelberg Institute of Theoretical Studies (HITS), the Institute of Mathematics of the Vietnam Academy of Science and Technology (VAST), the Interdisciplinary Center for Scientific Computing (IWR) at Heidelberg University, and the Vietnam Institute for Advanced Study in Mathematics, Ministry of Education The contributions cover a broad, interdisciplinary spectrum of scientific computing and showcase recent advances in theory, methods, and practical applications. Subjects covered numerical simulation, methods for optimization and control, parallel computing, and software development, as well as the applications of scientific computing in physics, mechanics, biomechanics and robotics, material science, hydrology, biotechnology, medicine, transport, scheduling, and in...

  7. 5th International conference on High Energy Density Laboratory Astrophysics

    CERN Document Server

    Kyrala, G.A

    2005-01-01

    During the past several years, research teams around the world have developed astrophysics-relevant utilizing high energy-density facilities such as intense lasers and z-pinches. Research is underway in many areas, such as compressible hydrodynamic mixing, strong shock phenomena, radiation flow, radiative shocks and jets, complex opacities, equations o fstat, and relativistic plasmas. Beyond this current research and the papers it is producing, plans are being made for the application, to astrophysics-relevant research, of the 2 MJ National Ignition Facility (NIF) laser at Lawrence Livermore National Laboratory; the 600 kj Ligne d'Intergration Laser (LIL) and the 2 MJ Laser Megajoule (LMJ) in Bordeaux, France; petawatt-range lasers now under construction around the world; and current and future Z pinches. The goal of this conference and these proceedings is to continue focusing and attention on this emerging research area. The conference brought together different scientists interested in this emerging new fi...

  8. High energy beam thermal processing of alpha zirconium alloys and the resulting articles

    International Nuclear Information System (INIS)

    Sabol, G.P.; McDonald, S.G.; Nurminen, J.I.

    1983-01-01

    Alpha zirconium alloy fabrication methods and resultant products exhibiting improved high temperature, high pressure steam corrosion resistance. The process, according to one aspect of this invention, utilizes a high energy beam thermal treatment to provide a layer of beta treated microstructure on an alpha zirconium alloy intermediate product. The treated product is then alpha worked to final size. According to another aspect of the invention, high energy beam thermal treatment is used to produce an alpha annealed microstructure in a Zircaloy alloy intermediate size or final size component. The resultant products are suitable for use in pressurized water and boiling water reactors

  9. Sc and neutron-capture abundances in Galactic low- and high-alpha field halo stars

    DEFF Research Database (Denmark)

    Fishlock, Cherie K.; Yong, D.; Karakas, Amanda I.

    2017-01-01

    We determine relative abundance ratios for the neutron-capture elements Zr, La, Ce, Nd and Eu for a sample of 27 Galactic dwarf stars with -1.5 stars separate into three populations (low-and high-a halo and thick-disc stars) based......-alpha stars have a lower abundance compared to the high-alpha stars. The low-alpha stars display the same abundance patterns of high [Ba/Y] and low [Y/Eu] as observed in present-day dwarf spheroidal galaxies, although with smaller abundance differences, when compared to the high-alpha stars. These distinct...... chemical patterns have been attributed to differences in the star formation rate between the two populations and the contribution of low-metallicity, low-mass asymptotic giant branch (AGB) stars to the low-alpha population. By comparing the low-alpha population with AGB stellar models, we place constraints...

  10. Use of Peltier cells in high resolution alpha spectrometry

    International Nuclear Information System (INIS)

    Bueno, C.C.; Santos, M.D.S.; Goncalves, J.A.C.

    1994-01-01

    The experiments with low-cost commercial silicon PIN photodiodes have shown the possibility of their transformation for use as alpha detectors with performance comparable with surface barrier detectors which are more expensive. Utilizing the silicon photodiode with reverse bias, an energy resolution for 241 Am alpha particles of 28 KeV and 23 KeV were obtained at room temperature and at -30 0 C respectively. (author). 4 refs, 4 figs

  11. Determination of radium-226 by high-resolution alpha spectrometry

    International Nuclear Information System (INIS)

    Sill, C.W.

    1983-01-01

    Condition were determined under which high resolution and accurate and reliable results can be obtained. Refractory solids are dissolved completely by fusion with KF and Ba-133 tracer. The fluoride cake is then transposed with sulfuric acid to a pyrosulfate fusion. Radium is precipitated with barium by addition of lead perchlorate to a dilute HCl solution of the pyrosulfate cake. The resulting insoluble sulfates are dissolved in an alkaline solution of DTPA and the Ra and Ba sulfates are reprecipitated with acetic acid to produce very small crystals. The precipitate is mounted on 0.1-μm membrane filter and analyzed by alpha spectrometry. Water samples are partially evaporated and treated similarly. Resolution, almost as good as with actinides electrodeposited on polished steel plates, is about 60 keV full-width-half-maximum with 100 μg of barium on a 1-inch filter with a 450 mm 2 detector at 20% counting efficiency. Recovery is about 97%. One solid sample can be prepared for counting in less than 2 hours. Methods are discussed for ensuring reliability of the results. Severe contamination of the surface-barrier detector by polonium-210 and recoil products is discussed

  12. Treatment of solid waste highly contaiminated by alpha emitters

    International Nuclear Information System (INIS)

    Madic, C.; Breschet, C.; Vigreux, B.

    1990-01-01

    In the recent years, efforts have been made in order to reduce the amount of alpha emitters essentially plutonium isotopes present in the solid wastes produced either during research experiments on fuel reprocessing, done in the Radiochemistry building in the centre d'etudes nucleaires de FONTENAY-AUX-ROSES (CEA, FRANCE), or in the MARCOULE reprocessing plant (COGEMA, FRANCE). The goals defined for the treatments of these different wastes were: to reduce their α and β, Y contamination levels; to recover the plutonium, a highly valuable material, and to minimize its quantity to be discharged with the wastes. To achieve these goals leaching processes using electrogenerated Ag (II(a very aggressive agent for PuO 2 )) in nitric acid solutions, were developed and several facilities were designed and built to operate the processes. A brief description of the process and of the different facilities will be presented in this paper; the main results obtained in ELISE and PROLIXE are also summarized

  13. Treatment of solid waste highly contaminated by alpha emitters

    International Nuclear Information System (INIS)

    Madic, C.; Breschet, C.; Vigreaux, B.

    1990-01-01

    In the recent years, efforts have been made in order to reduce the amount of alpha emitters essentially plutonium isotopes present in the solid wastes produced either during research experiments on fuel reprocessing, done in the Radiochemistry building in the centre d'etudes nuclearires de FONTENAY-AUX-ROSES (CEA, FRANCE), or in the MARCOULE reprocessing plant (COGEMA, FRANCE). The goals defined for the treatments of these different wastes were: to reduce their α and β, γ, contamination levels. and to recover the plutonium, an highly valuable material, and to minimize its quantity to be discharged with the wastes. To achieve these goals leaching processes using electrogenerated Ag (II (a very aggressive agent for PuO 2 )) in nitric acid solutions, were developed and several facilities were designed and built to operate the processes: ELISE and PROLIXE facilities: PILOT ASHES FACILITY for delete, the treatment of plutonium contaminated ashes (COGEMA, MARCOULE). A brief description of the process and of the different facilities will be presented in this paper; the main results obtained in ELISE and PROLIXE are also summarized

  14. 2003 Conference for Computing in High Energy and Nuclear Physics

    International Nuclear Information System (INIS)

    Schalk, T.

    2003-01-01

    The conference was subdivided into the follow separate tracks. Electronic presentations and/or videos are provided on the main website link. Sessions: Plenary Talks and Panel Discussion; Grid Architecture, Infrastructure, and Grid Security; HENP Grid Applications, Testbeds, and Demonstrations; HENP Computing Systems and Infrastructure; Monitoring; High Performance Networking; Data Acquisition, Triggers and Controls; First Level Triggers and Trigger Hardware; Lattice Gauge Computing; HENP Software Architecture and Software Engineering; Data Management and Persistency; Data Analysis Environment and Visualization; Simulation and Modeling; and Collaboration Tools and Information Systems

  15. Jet Production in ep Collisions at High $Q^2$ and Determination of $\\alpha_s$

    CERN Document Server

    Aaron, F.D.; Alimujiang, K.; Andreev, V.; Antunovic, B.; Asmone, A.; Backovic, S.; Baghdasaryan, A.; Barrelet, E.; Bartel, W.; Begzsuren, K.; Belousov, A.; Bizot, J.C.; Boudry, V.; Bozovic-Jelisavcic, I.; Bracinik, J.; Brandt, G.; Brinkmann, M.; Brisson, V.; Bruncko, D.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A.J.; Cantun Avila, K.B.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Cholewa, A.; Contreras, J.G.; Coughlan, J.A.; Cozzika, G.; Cvach, J.; Dainton, J.B.; Daum, K.; Deak, M.; de Boer, Y.; Delcourt, B.; Del Degan, M.; Delvax, J.; De Roeck, A.; De Wolf, E.A.; Diaconu, C.; Dodonov, V.; Dossanov, A.; Dubak, A.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eliseev, A.; Elsen, E.; Falkiewicz, A.; Faulkner, P.J.W.; Favart, L.; Fedotov, A.; Felst, R.; Feltesse, J.; Ferencei, J.; Fischer, D.-J.; Fleischer, M.; Fomenko, A.; Gabathuler, E.; Gayler, J.; Ghazaryan, Samvel; Glazov, A.; Glushkov, I.; Goerlich, L.; Gogitidze, N.; Gouzevitch, M.; Grab, C.; Greenshaw, T.; Grell, B.R.; Grindhammer, G.; Habib, S.; Haidt, D.; Helebrant, C.; Henderson, R.C.W.; Hennekemper, E.; Henschel, H.; Herbst, M.; Herrera, G.; Hildebrandt, M.; Hiller, K.H.; Hoffmann, D.; Horisberger, R.; Hreus, T.; Jacquet, M.; Janssen, M.E.; Janssen, X.; Jemanov, V.; Jonsson, L.; Jung, Andreas Werner; Jung, H.; Kapichine, M.; Katzy, J.; Kenyon, I.R.; Kiesling, C.; Klein, M.; Kleinwort, C.; Kluge, T.; Knutsson, A.; Kogler, R.; Korbel, V.; Kostka, P.; Kraemer, M.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Kruger, K.; Kutak, K.; Landon, M.P.J.; Lange, W.; Lastovicka-Medin, G.; Laycock, P.; Lebedev, A.; Leibenguth, G.; Lendermann, V.; Levonian, S.; Li, G.; Lipka, K.; Liptaj, A.; List, B.; List, J.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lytkin, L.; Makankine, A.; Malinovski, E.; Marage, P.; Marti, Ll.; Martyn, H.-U.; Maxfield, S.J.; Mehta, A.; Meyer, A.B.; Meyer, H.; Meyer, H.; Meyer, J.; Michels, V.; Mikocki, S.; Milcewicz-Mika, I.; Moreau, F.; Morozov, A.; Morris, J.V.; Mozer, Matthias Ulrich; Mudrinic, M.; Muller, K.; Murin, P.; Naroska, B.; Naumann, Th.; Newman, P.R.; Niebuhr, C.; Nikiforov, A.; Nowak, G.; Nowak, K.; Nozicka, M.; Olivier, B.; Olsson, J.E.; Osman, S.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Pandurovic, M.; Papadopoulou, Th.; Pascaud, C.; Patel, G.D.; Pejchal, O.; Perez, E.; Petrukhin, A.; Picuric, I.; Piec, S.; Pitzl, D.; Placakyte, R.; Pokorny, B.; Polifka, R.; Povh, B.; Preda, T.; Radescu, V.; Rahmat, A.J.; Raicevic, N.; Raspiareza, A.; Ravdandorj, T.; Reimer, P.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Ruiz Tabasco, J.E.; Rurikova, Z.; Rusakov, S.; Salek, D.; Sankey, D.P.C.; Sauter, M.; Sauvan, E.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schoning, A.; Schultz-Coulon, H.-C.; Sefkow, F.; Shaw-West, R.N.; Sheviakov, I.; Shtarkov, L.N.; Shushkevich, S.; Sloan, T.; Smiljanic, Ivan; Soloviev, Y.; Sopicki, P.; South, D.; Spaskov, V.; Specka, Arnd E.; Staykova, Z.; Steder, M.; Stella, B.; Stoicea, G.; Straumann, U.; Sunar, D.; Sykora, T.; Tchoulakov, V.; Thompson, G.; Thompson, P.D.; Toll, T.; Tomasz, F.; Tran, T.H.; Traynor, D.; Trinh, T.N.; Truol, P.; Tsakov, I.; Tseepeldorj, B.; Turnau, J.; Urban, K.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Vargas Trevino, A.; Vazdik, Y.; Vinokurova, S.; Volchinski, V.; von den Driesch, M.; Wegener, D.; Wissing, Ch.; Wunsch, E.; Zacek, J.; Zalesak, J.; Zhang, Z.; Zhokin, A.; Zimmermann, T.; Zohrabyan, H.; Zomer, F.; Zus, R.

    2010-01-01

    The production of jets is studied in deep-inelastic ep scattering at large negative four momentum transfer squared 150alpha_s(M_Z) = 0.1168 +/-0.0007 (exp.) +0.0046/-0.0030 (th.) +/-0.0016(pdf).

  16. Real-time monitoring for alpha emitters in high-airflow environments

    International Nuclear Information System (INIS)

    Koster, J.E.; MacArthur, D.W.; Bounds, J.A.; Rawool-Sullivan, M.; Whitley, C.R.; Conaway, J.G.; Steadman, P.A.

    1996-01-01

    Key problems in detecting alpha contamination for site characterization and decontamination and decommissioning that remain to be solved include measurement of airborne contamination, material holdup within pipes, and leakage of material containers. These problems are very difficult using traditional alpha detectors and systems. The ionization detection method (long-range alpha detection of LRAD) offers a number of specific advantages for these environmental measurements. An LRAD system detects the air molecules ionized by alpha-emitting contamination rather than the alpha particles. Thus, LRAD-based detectors are not limited by the short range of alpha particles and can be used to detect contamination anywhere that air can penetrate. Extending this technology to large enclosures of long pipes requires a system optimized for large airflows. In this paper we will present designs and preliminary results for high-volume flow-through air monitors based on the LRAD technique. In addition, we will discuss the behavior of the monitors and their potential applications

  17. Intrahepatic hematoma: hepatic lesion in a newborn with high {alpha}-fetoprotein level

    Energy Technology Data Exchange (ETDEWEB)

    Lam, Chiu Ying Flora; Chan, Kui Fai; Fan, Tsz Wo; Kwok, Chong Hei Philip; Chan, Chi Hum Susan; Tsang, Tsz Kan [Queen Elizabeth Hospital, Department of Radiology and Imaging, Hong Kong (China)

    2005-11-01

    Hepatic hematomas are relatively common in fetuses and neonates; most are subcapsular in location. Sometimes their imaging features can be non-specific, so differentiation from other aggressive lesions like hepatoblastoma can be difficult, especially if there is a concurrent high {alpha}-fetoprotein level. We report a case of intrahepatic hematoma with a rising {alpha}-fetoprotein level. (orig.)

  18. CHARACTERIZATION OF A NEW BACILLUS-STEAROTHERMOPHILUS ISOLATE - A HIGHLY THERMOSTABLE ALPHA-AMYLASE-PRODUCING STRAIN

    NARCIS (Netherlands)

    WIND, RD; BUITELAAR, RM; EGGINK, G; HUIZING, HJ; DIJKHUIZEN, L

    A novel strain of Bacillus stearothermophilus was isolated from samples of a potato-processing industry. Compared to known alpha-amylases from other B. stearothermophilus strains, the isolate was found to produce a highly thermostable alpha-amylase. The half-time of inactivation of this

  19. 2012 Aspen Winter Conferences on High Energy and Astrophysics

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, John [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Olivier, Dore [California Inst. of Technology (CalTech), Pasadena, CA (United States); Fox, Patrick [Aspen Center for Physics, CO (United States); Furic, Ivan [Univ. of Florida, Gainesville, FL (United States); Halkiadakis, Eva [Rutgers Univ., Piscataway, NJ (United States); Schmidt, Fabian [California Inst. of Technology (CalTech), Pasadena, CA (United States); Senatore, Leonardo [Stanford Univ., CA (United States); Smith, Kendrick M. [Princeton Univ., NJ (United States); Whiteson, Daniel [Univ. of California, Irvine, CA (United States)

    2012-05-01

    Aspen Center for Physics Project Summary DE-SC0007313 Budget Period: 1/1/2012 to 12/31/2012 The Hunt for New Particles, from the Alps to the Plains to the Rockies The 2012 Aspen Winter Conference on Particle Physics was held at the Aspen Center for Physics from February 11 to February 17, 2012. Sixty-seven participants from nine countries, and several universities and national labs attended the workshop titled, The Hunt for New Particles, from the Alps to the Plains to the Rockies. There were 53 formal talks, and a considerable number of informal discussions held during the week. The weeks events included a public lecture-Hunting the Dark Universe given by Neal Weiner from New York University) and attended by 237 members of the public, and a physics cafe geared for high schoolers that is a discussion with physicists conducted by Spencer Chang (University of Oregon), Matthew Reece (Harvard University) and Julia Shelton (Yale University) and attended by 67 locals and visitors. While there were no published proceedings, some of the talks are posted online and can be Googled. The workshop was organized by John Campbell (Fermilab), Patrick Fox (Fermilab), Ivan Furic (University of Florida), Eva Halkiadakis (Rutgers University) and Daniel Whiteson (University of California Irvine). Additional information is available at http://indico.cern.ch/conferenceDisplay.py?confId=143360. Inflationary Theory and its Confrontation with Data in the Planck Era The 2012 Aspen Winter Conference on Astroparticle physics held at the Aspen Center for Physics was Inflationary Theory and its Confrontation with Data in the Planck Era. It was held from January 30 to February 4, 2012. The 62 participants came from 7 countries and attended 43 talks over five days. Late mornings through the afternoon are reserved for informal discussions. In feedback received from participants, it is often these unplanned chats that produce the most excitement due to working through problems with fellow physicists

  20. Alpha lipoic acid attenuates high-fructose-induced pancreatic toxicity.

    Science.gov (United States)

    Topsakal, Senay; Ozmen, Ozlem; Cankara, Fatma Nihan; Yesilot, Sukriye; Bayram, Dilek; Genç Özdamar, Nilüfer; Kayan, Sümeyra

    2016-01-01

    Chronic consumption of high-fructose corn syrup (HFCS) causes several problems such as insulin resistance. The goal of the study was to investigate pancreatic damage induced by chronic HFCS consumption and the protective effects of alpha lipoic acid (ALA) on pancreatic cells. Wistar Albino, 4-month-old, female rats weighing 250-300 g were randomly distributed into three groups, each containing eight rats. The study included an HFCS group, an HFCS + ALA-administered group and a control group (CON). The prepared 30% solution of HFCS (F30) (24% fructose, 28% dextrose) was added to the drinking water for 10 weeks. ALA treatment was begun 4 weeks after the first HFCS administration (100 mg/kg/oral, last 6 weeks). Rats were anaesthetised and euthanised by cervical dislocation 24 h after the last ALA administration. Blood samples for biochemical tests (amylase, lipase, malondialdehyde (MDA) and catalase (CAT)) and tissue samples for histopathological and immunohistochemical examinations (caspase-3, insulin and glucagon) were collected. Comparing the control and HFCS groups, serum glucose (150.92 ± 39.77 and 236.50 ± 18.28, respectively, p < 0.05), amylase (2165.00 ± 150.76 and 3027.66 ± 729.19, respectively, p < 0.01), lipase (5.58 ± 2.22 and 11.51 ± 2.74, respectively, p < 0.01) and pancreatic tissue MDA (0.0167 ± 0.004 and 0.0193 ± 0.006, respectively, p < 0.05) levels were increased, whereas tissue CAT (0.0924 ± 0.029 and 0.0359 ± 0.023, respectively, p < 0.05) activity decreased in the HFCS group significantly. Histopathological examination revealed degenerative and necrotic changes in Langerhans islet cells and slight inflammatory cell infiltration in pancreatic tissue in the HFCS group. Immunohistochemically there was a significant decrease in insulin (2.85 ± 0.37 and 0.87 ± 0.64, respectively, p < 0.001) and glucagon (2.71 ± 0.48 and 1.00 ± 0.75, respectively, p < 0.001) secreting cell scores, whereas a

  1. A basic research of gadolinium hydrogen [alpha], [alpha]', [alpha]'', [alpha]'''-tetramethly- 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetate with high complex stability as a contrast agent for MRI

    Energy Technology Data Exchange (ETDEWEB)

    Seri, Shigemi; Hashiguchi, Yuji; Kubomura, Kan; Abe, Yukiko; Iguchi, Toshio; Iwai, Kumiko [Nihon Medi-Physics Co., Ltd., Sodegaura, Chiba (Japan); Watanabe, Tokuko

    1993-05-01

    Gadolinium hydrogen [alpha], [alpha]', [alpha]'', [alpha]'''-tetramethyl- 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetate (abbreviated Gd-DOTMA) was developed as a new contrast agent for magnetic resonance imaging. Our study focused on the evaluation of the pharmaceutical properties as in vivo agent. The new modified process by which Gd-DOTMA was synthesized resulted in high yields of this agent. A high stability constant of 10[sup 26] fro Gd-DOTMA was determined at physiological pH. It is more stable than Gd complex with tetraazacyclododecanetetraacetic acid (which is regarded as the most stable Gd complex). The strong T[sub 1] relaxivities of 4.0 and 3.7 (mM [center dot] s)[sup -1] at 0.5 tesla and 1.5 tesla were measured in the aqueous solution. The osmolarity of 0.5 M solution, dissolved with equal amounts of meglumine as a solubilizer is 1020 mOsmol/kg. This contrasting agent was studied in vivo by using rats as the experimental group. The agent showed strong enhancement of transplanted tumors within the rat population studied. This compound is rapidly excreted by the kidneys, and has a half-life of 26 min in blood. The median lethal dose (LD[sub 50] value) of the stable Gd-DOTMA has a favorable tolerance of over 12.3 mmol/kg. (author).

  2. Proceedings of the conference on numerical methods in high temperature physics

    International Nuclear Information System (INIS)

    Alcouffe, R.E.; Holm, D.D.; O'Rourke, P.J.

    1988-11-01

    These proceedings contain full papers presented at the Los Alamos Conference on High Temperature Physics. This conference discussed many aspects of high temperature physics including hydrodynamics, radiation and particle transport and some computational issues important for efficient calculations. The meetings was held between researchers from Los Alamos and the French Commissariat a L'Energy Atomique

  3. Proceedings of the conference on numerical methods in high temperature physics

    Energy Technology Data Exchange (ETDEWEB)

    Alcouffe, R.E.; Holm, D.D.; O' Rourke, P.J. (comps.)

    1988-11-01

    These proceedings contain full papers presented at the Los Alamos Conference on High Temperature Physics. This conference discussed many aspects of high temperature physics including hydrodynamics, radiation and particle transport and some computational issues important for efficient calculations. The meetings was held between researchers from Los Alamos and the French Commissariat a L'Energy Atomique (CEA).

  4. At the XI International Conference on High Energy Accelerators

    CERN Multimedia

    CERN PhotoLab

    1980-01-01

    The Conference was held at CERN and attracted some 300 specialists (see CERN Courier 1980 p. 231). The conference was a success thanks also to many CERN people. Here, first raw, Susannah Tracy, Ingrid Barnett, ..?, Danièle Lajust, Simon Newman, Owen Lock. Second raw, (2) Ed Powell, (3) Ernest Bissa, (7) Myrna Guarisco, (8) Barbara Strasser, (10) Michèle Compoint, (11) Anne Caton, (12) Mike Crowley-Milling.

  5. Estimated environmental loads of alpha-amylase from transgenic high-amylase maize

    Energy Technology Data Exchange (ETDEWEB)

    Wolt, Jeffrey D. [Department of Agronomy, Iowa State University, Ames, IA 50011 (United States); Biosafety Institute for Genetically Modified Agricultural Products, 164 Seed Science, Iowa State University, Ames, IA 50011 (United States); Karaman, Sule [Biosafety Institute for Genetically Modified Agricultural Products, 164 Seed Science, Iowa State University, Ames, IA 50011 (United States)

    2007-11-15

    Environmental exposure of plants bioengineered to improve efficiencies of biofuel production is an important consideration for their adoption. High-amylase maize genetically engineered to produce thermostable alpha-amylase in seed endosperm is currently in development, and its successful adoption will entail >1000 km{sup 2} of annual production in the USA. Environmental exposure of thermostable amylase will occur in production fields from preharvest and harvest dropped grain, with minor additional contributions from stover and root biomass. Mass loadings of thermostable alpha-amylase are projected to be 16 kg km{sup -2} and represent a potential source of increased alpha-amylase activity in receiving soils. An understanding of the degradation, persistence, accumulation, and activity of thermostable alpha-amylase introduced from transgenic high-amylase maize will be necessary in order to effectively manage transgenic crop systems intended or biofeedstock production. (author)

  6. High-Alpha Research Vehicle (HARV) longitudinal controller: Design, analyses, and simulation resultss

    Science.gov (United States)

    Ostroff, Aaron J.; Hoffler, Keith D.; Proffitt, Melissa S.; Brown, Philip W.; Phillips, Michael R.; Rivers, Robert A.; Messina, Michael D.; Carzoo, Susan W.; Bacon, Barton J.; Foster, John F.

    1994-01-01

    This paper describes the design, analysis, and nonlinear simulation results (batch and piloted) for a longitudinal controller which is scheduled to be flight-tested on the High-Alpha Research Vehicle (HARV). The HARV is an F-18 airplane modified for and equipped with multi-axis thrust vectoring. The paper includes a description of the facilities, a detailed review of the feedback controller design, linear analysis results of the feedback controller, a description of the feed-forward controller design, nonlinear batch simulation results, and piloted simulation results. Batch simulation results include maximum pitch stick agility responses, angle of attack alpha captures, and alpha regulation for full lateral stick rolls at several alpha's. Piloted simulation results include task descriptions for several types of maneuvers, task guidelines, the corresponding Cooper-Harper ratings from three test pilots, and some pilot comments. The ratings show that desirable criteria are achieved for almost all of the piloted simulation tasks.

  7. Alpha band frequency differences between low-trait and high-trait anxious individuals.

    Science.gov (United States)

    Ward, Richard T; Smith, Shelby L; Kraus, Brian T; Allen, Anna V; Moses, Michael A; Simon-Dack, Stephanie L

    2018-01-17

    Trait anxiety has been shown to cause significant impairments on attentional tasks. Current research has identified alpha band frequency differences between low-trait and high-trait anxious individuals. Here, we further investigated the underlying alpha band frequency differences between low-trait and high-trait anxious individuals during their resting state and the completion of an inhibition executive functioning task. Using human participants and quantitative electroencephalographic recordings, we measured alpha band frequency in individuals both high and low in trait anxiety during their resting state, and while they completed an Eriksen Flanker Task. Results indicated that high-trait anxious individuals exhibit a desynchronization in alpha band frequency from a resting state to when they complete the Eriksen Flanker Task. This suggests that high-trait anxious individuals maintain fewer attentional resources at rest and must martial resources for task performance as compared with low-trait anxious individuals, who appear to maintain stable cognitive resources between rest and task performance. These findings add to the cognitive neuroscience literature surrounding the role of alpha band frequency in low-trait and high-trait anxious individuals.

  8. Characterization of saturation of CR-39 detector at high alpha-particle fluence

    Directory of Open Access Journals (Sweden)

    M. El Ghazaly

    2018-04-01

    Full Text Available The occurrence of saturation in the CR-39 detector reduces and limits its detection dynamic range; nevertheless, this range could be extended using spectroscopic techniques and by measuring the net bulk rate of the saturated CR-39 detector surface. CR-39 detectors were irradiated by 1.5 MeV high alpha-particle fluence varying from 0.06 × 108 to 7.36 × 108 alphas/cm2 from Am-241 source; thereafter, they were etched in a 6.25N NaOH solution at a temperature of 70°C for different durations. Net bulk etch rate measurement of the 1.5 MeV alpha-irradiated CR-39 detector surface revealed that rate increases with increasing etching time and reaches its maximum value at the end of the alpha-particle range. It is also correlated with the alpha-particle fluence. The measurements of UV–Visible (UV–Vis absorbance at 500 and 600 nm reveal that the absorbance is linearly correlated with the fluence of alpha particles at the etching times of 2 and 4 hour. For extended etching times of 6, 10, and 14.5 hour, the absorbance is saturated for fluence values of 4.05 × 108, 5.30 × 108, and 7.36 × 108 alphas/cm2. These new methods pave the way to extend the dynamic range of polymer-based solid state nuclear track detectors (SSNTDs in measurement of high fluence of heavy ions as well as in radiation dosimetry. Keywords: Alpha Particle, Bulk Etch Rate, CR-39 Detector, Saturated Regime, UV–Vis Spectroscopy

  9. Plasmodium vivax merozoite surface protein-3 alpha: a high-resolution marker for genetic diversity studies.

    Science.gov (United States)

    Prajapati, Surendra Kumar; Joshi, Hema; Valecha, Neena

    2010-06-01

    Malaria, an ancient human infectious disease caused by five species of Plasmodium, among them Plasmodium vivax is the most widespread human malaria species and causes huge morbidity to its host. Identification of genetic marker to resolve higher genetic diversity for an ancient origin organism is a crucial task. We have analyzed genetic diversity of P. vivax field isolates using highly polymorphic antigen gene merozoite surface protein-3 alpha (msp-3 alpha) and assessed its suitability as high-resolution genetic marker for population genetic studies. 27 P. vivax field isolates collected during chloroquine therapeutic efficacy study at Chennai were analyzed for genetic diversity. PCR-RFLP was employed to assess the genetic variations using highly polymorphic antigen gene msp-3 alpha. We observed three distinct PCR alleles at msp-3 alpha, and among them allele A showed significantly high frequency (53%, chi2 = 8.22, p = 0.001). PCR-RFLP analysis revealed 14 and 17 distinct RFLP patterns for Hha1 and Alu1 enzymes respectively. Further, RFLP analysis revealed that allele A at msp-3 alpha is more diverse in the population compared with allele B and C. Combining Hha1 and Alu1 RFLP patterns revealed 21 distinct genotypes among 22 isolates reflects higher diversity resolution power of msp-3 alpha in the field isolates. P. vivax isolates from Chennai region revealed substantial amount of genetic diversity and comparison of allelic diversity with other antigen genes and microsatellites suggesting that msp-3 alpha could be a high-resolution marker for genetic diversity studies among P. vivax field isolates.

  10. 77 FR 24669 - Atlantic Highly Migratory Species; Public Conference Call Regarding Recreational Yellowfin Tuna...

    Science.gov (United States)

    2012-04-25

    ... collection in the U.S. recreational yellowfin tuna fishery and the relationship to international yellowfin...-XB162 Atlantic Highly Migratory Species; Public Conference Call Regarding Recreational Yellowfin Tuna... Administration (NOAA), Commerce. ACTION: Notice of public conference call. SUMMARY: In order to better inform the...

  11. Conference on atomic processes in high temperature plasmas: a topical conference of the American Physical Society Division of Plasma Physics

    International Nuclear Information System (INIS)

    1977-01-01

    Abstracts are included for approximately 100 of the papers presented at the meeting. The following sessions were held at the conference: (1) electron ionization and excitation rates, (2) radiation from low density plasmas, (3) electron-ion cross sections and rates, (4) oscillator strengths and atomic structure, (5) spectroscopy and atomic structure, (6) astrophysical plasmas, (7) particle transport, (8) ion-atom cross sections and rates, (9) wall effects in laboratory plasmas, (10) spectroscopy and photoionization, and (11) radiation from high density plasmas

  12. 1991 Conference summary on computing in high energy physics

    International Nuclear Information System (INIS)

    Loken, S.C.

    1991-03-01

    The papers presented at the Conference cover a wide range of important issues in software engineering and management. They indicate a trend toward more use of commercial systems and standards. This trend will likely have a significant influence on plans for future systems

  13. Nuclear reactions induced by high-energy alpha particles

    Science.gov (United States)

    Shen, B. S. P.

    1974-01-01

    Experimental and theoretical studies of nuclear reactions induced by high energy protons and heavier ions are included. Fundamental data needed in the shielding, dosimetry, and radiobiology of high energy particles produced by accelerators were generated, along with data on cosmic ray interaction with matter. The mechanism of high energy nucleon-nucleus reactions is also examined, especially for light target nuclei of mass number comparable to that of biological tissue.

  14. 38th International Conference on High Energy Physics

    CERN Document Server

    2016-01-01

    The U.S. particle physics community is proud to host the 38th ICHEP conference in Chicago from the 3rd to the 10th August 2016. ICHEP is a focal point of the field of particle physics, brining together leading experimentalists and theorists of the world. It was first held in 1950, and is biennial since 1960. At ICHEP all areas of particle physics including neutrino, flavor, astro-particle and new physics beyond the Standard Model share the exciting results obtained in the field and exchange views among all experimental and theoretical scientists of the world including students and postodcs. The conference will consist of parallel and invited plenary sessions. A poster session will emphasize the work of young students.

  15. Characterization of high level waste for minor actinides by chemical separation and alpha spectrometry

    International Nuclear Information System (INIS)

    Murali, M.S.; Bhattacharayya, A.; Kar, A.S.; Tomar, B.S.; Manchanda, V.K.

    2010-01-01

    Quantification of minor actinides present in of High Level Waste (HLW) solutions originating from the power reactors is important in view of management of radioactive wastes and actinide partitioning. Several methods such as ICP-MS, X-ray fluorescence methods, ICP-AES, alpha spectrometry are used in characterizing such types of wastes. As alpha spectrometry is simple and reliable, this technique has been used for the estimation of minor actinides after devising steps of separation for estimating Np and Pu present in HLW solutions of PHWR origin. Using a wealth of knowledge appropriate to the solution chemistry of actinides, the task of separation, though appears easy, it is challenging job for a radiochemist handling high-dose HLW samples, for obtaining clean alpha peaks for Np and Pu. This paper reports on the successful attempt made to quantify 241 Am, 244 Cm, Pu (239 mainly) and 237 Np present in HLW-PHWR obtained from PREFRE, Tarapur

  16. International Conference: Computer-Aided Design of High-Temperature Materials

    National Research Council Canada - National Science Library

    Kalia, Rajiv

    1998-01-01

    .... The conference was attended by experimental and computational materials scientists, and experts in high performance computing and communications from universities, government laboratories, and industries in the U.S., Europe, and Japan...

  17. Conference Analysis Report of Assessments on Defect and Damage for a High Temperature Structure

    International Nuclear Information System (INIS)

    Lee, Hyeong Yeon

    2008-11-01

    This report presents the analysis on the state-of-the-art research trends on creep-fatigue damage, defect assessment of high temperature structure, development of heat resistant materials and their behavior at high temperature based on the papers presented in the two international conferences of ASME PVP 2008 which was held in Chicago in July 2008 and CF-5(5th International Conference on Creep, Fatigue and Creep-Fatigue) which was held in Kalpakkam, India in September 2008

  18. Conference Analysis Report of Assessments on Defect and Damage for a High Temperature Structure

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyeong Yeon

    2008-11-15

    This report presents the analysis on the state-of-the-art research trends on creep-fatigue damage, defect assessment of high temperature structure, development of heat resistant materials and their behavior at high temperature based on the papers presented in the two international conferences of ASME PVP 2008 which was held in Chicago in July 2008 and CF-5(5th International Conference on Creep, Fatigue and Creep-Fatigue) which was held in Kalpakkam, India in September 2008.

  19. High temperature slagging incinerator for alpha contaminated wastes

    International Nuclear Information System (INIS)

    Van de Voorde, N.

    1985-01-01

    This report describes the experiences collected by the treatment of plutonium-contaminated wastes, in the High Temperature Slagging Incinerator at the C.E.N./S.C.K. at Mol, with the support of the Commission of the European Communities. The major objective of the exercise is to demonstrate the operability of this facility for the treatment of mixed transuranic (TRU) and beta-gamma solid waste material. The process will substantially reduce the TRU waste volume by burning the combustibles and converting the non-combustibles into a chemically inert and physically stable basalt-like slag product, suitable for safe transport and final disposal. (Auth.)

  20. Identification of distal regulatory regions in the human alpha IIb gene locus necessary for consistent, high-level megakaryocyte expression.

    Science.gov (United States)

    Thornton, Michael A; Zhang, Chunyan; Kowalska, Maria A; Poncz, Mortimer

    2002-11-15

    The alphaIIb/beta3-integrin receptor is present at high levels only in megakaryocytes and platelets. Its presence on platelets is critical for hemostasis. The tissue-specific nature of this receptor's expression is secondary to the restricted expression of alphaIIb, and studies of the alphaIIb proximal promoter have served as a model of a megakaryocyte-specific promoter. We have examined the alphaIIb gene locus for distal regulatory elements. Sequence comparison between the human (h) and murine (m) alphaIIb loci revealed high levels of conservation at intergenic regions both 5' and 3' to the alphaIIb gene. Additionally, deoxyribonuclease (DNase) I sensitivity mapping defined tissue-specific hypersensitive (HS) sites that coincide, in part, with these conserved regions. Transgenic mice containing various lengths of the h(alpha)IIb gene locus, which included or excluded the various conserved/HS regions, demonstrated that the proximal promoter was sufficient for tissue specificity, but that a region 2.5 to 7.1 kb upstream of the h(alpha)IIb gene was necessary for consistent expression. Another region 2.2 to 7.4 kb downstream of the gene enhanced expression 1000-fold and led to levels of h(alpha)IIb mRNA that were about 30% of the native m(alpha)IIb mRNA level. These constructs also resulted in detectable h(alpha)IIb/m(beta)3 on the platelet surface. This work not only confirms the importance of the proximal promoter of the alphaIIb gene for tissue specificity, but also characterizes the distal organization of the alphaIIb gene locus and provides an initial localization of 2 important regulatory regions needed for the expression of the alphaIIb gene at high levels during megakaryopoiesis.

  1. High-level expression of the native barley alpha-amylase/subtilisin inhibitor in Pichia pastoris

    DEFF Research Database (Denmark)

    Micheelsen, Pernille Ollendorff; Ostergaard, Peter Rahbek; Lange, Lene

    2008-01-01

    An expression system for high-level expression of the native Hordeum vulgare alpha-amylase/subtilisin inhibitor (BASI) has been developed in Pichia pastoris, using the methanol inducible alcohol oxidase 1 (AOX1) promoter. To optimize expression, two codon-optimized coding regions have been designed...... and expressed alongside the wild-type coding region. To ensure secretion of the native mature protein, a truncated version of the alpha mating factor secretion signal from Saccharomyces cerevisiae was used. In order to be able to compare expression levels from different clones, single insertion transformants...

  2. Operation of a high-purity silicon diode alpha particle detector at 1.4 K

    International Nuclear Information System (INIS)

    Martoff, C.J.; Kaczanowicz, E.; Neuhauser, B.J.; Lopez, E.; Zhang, Y.; Ziemba, F.P.

    1991-01-01

    Detection of alpha particles at temperatures as low as 1.4 K was demonstrated using a specially fabricated Si diode. The diode was 475 mm 2 by 0.280 mm thick, fabricated from high-purity silicon with degenerately doped contacts. This is an important step toward development of dual-mode (ionization plus phonon) silicon detectors for low energy radiation. (orig.)

  3. XII All-Russian conference Diagnostics of high-temperature plasma. Abstracts of reports and conference program

    International Nuclear Information System (INIS)

    2007-01-01

    Abstracts of reports made on the XII All-Russian conference on high-temperature plasma diagnostics are presented. The different methods of hot plasma diagnostics are considered, namely microwave diagnostic methods, laser diagnostic techniques, X-ray plasma diagnostics and corpuscular diagnostic methods. The particular attention is given to wall plasma diagnostics and diagnostics of inertial synthesis systems. Current diagnostic tools and metrological provision for plasma diagnostics are considered. The diagnostic complexes of thermonuclear devices are described. The problems of experimental data processing are discussed [ru

  4. Proceedings of the fourth High-Energy Physics International Conference HEP-MAD 09

    International Nuclear Information System (INIS)

    Narison, S.

    2009-01-01

    This is the 4th of the series of HEP-MAD conference organized regularly every 2 or 3 years in Madagascar, in alternance to the traditional series of QCD-conference held in Montpellier (France) on July. The conference is expected to involve few numbers of physicists from abroad and equal numbers of experimental and theoretical high-energy physicists.Unlike the QCD conference which is a specialized meeting, HEP-MAD aims to have a wide view of physics: from High-Energy to Astro Physics. National contributions cover Nuclear and Environment Physics and the new form of energies (solar,...). This conference is a compromise between a standard one where specialized topics are presented and an introductory school to each subjects.It gives the opportunuity for high-energy physicists to promote the field of high-energy physics (theory and experiments)in Madagascar. In the same time, the meeting will permit to the participants to discover the country (well-known about its bio-diversity and rare animal and plant species) and its tradition and population from different origins.The theoretical and experimental talks cover different aspects of high-energy physics which are in the form of introductional reviews to the field, short contributions and posters. These talks are complemented by other national talks in other areas of physics. The Conference is expected to be published on-line by SLAC in a eConf-proceedings.

  5. High linear energy transfer degradation studies simulating alpha radiolysis of TRU solvent extraction processes

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, Jeremy [Department of Chemical Engineering and Materials Science - University of California Irvine, 916 Engineering Tower, Irvine, CA, 92697 (United States); Miller, George [Department of Chemistry- University of California Irvine, 2046D PS II, Irvine, CA, 92697 (United States); Nilsson, Mikael [Department of Chemical Engineering and Materials Science - University of California Irvine, 916 Engineering Tower, Irvine, CA, 92697 (United States)

    2013-07-01

    Treatment of used nuclear fuel through solvent extraction separation processes is hindered by radiolytic damage from radioactive isotopes present in used fuel. The nature of the damage caused by the radiation may depend on the radiation type, whether it be low linear energy transfer (LET) such as gamma radiation or high LET such as alpha radiation. Used nuclear fuel contains beta/gamma emitting isotopes but also a significant amount of transuranics which are generally alpha emitters. Studying the respective effects on matter of both of these types of radiation will allow for accurate prediction and modeling of process performance losses with respect to dose. Current studies show that alpha radiation has milder effects than that of gamma. This is important to know because it will mean that solvent extraction solutions exposed to alpha radiation may last longer than expected and need less repair and replacement. These models are important for creating robust, predictable, and economical processes that have strong potential for mainstream adoption on the commercial level. The effects of gamma radiation on solvent extraction ligands have been more extensively studied than the effects of alpha radiation. This is due to the inherent difficulty in producing a sufficient and confluent dose of alpha particles within a sample without leaving the sample contaminated with long lived radioactive isotopes. Helium ion beam and radioactive isotope sources have been studied in the literature. We have developed a method for studying the effects of high LET radiation in situ via {sup 10}B activation and the high LET particles that result from the {sup 10}B(n,a){sup 7}Li reaction which follows. Our model for dose involves solving a partial differential equation representing absorption by 10B of an isentropic field of neutrons penetrating a sample. This method has been applied to organic solutions of TBP and CMPO, two ligands common in TRU solvent extraction treatment processes. Rates

  6. Support for the 38th International Conference on High Energy Physics, 3-10 August 2016

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young-Kee [Univ. of Chicago, IL (United States)

    2017-06-19

    The 38th International Conference on High Energy Physics (ICHEP) held in Chicago from August 3 to 10, 2016 was for physicists from around the world to gather to share the latest advancements in particle physics, astrophysics/cosmology, and accelerator science and to discuss plans for major future facilities. DOE funding provided partial support for space rental audio-visual services for scientific presentations at the conference.

  7. High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes

    DEFF Research Database (Denmark)

    Sandmand, Marie; Bruunsgaard, Helle; Kemp, Kåre

    2003-01-01

    BACKGROUND: Aging is characterized by increased inflammatory activity reflected by increased plasma levels of proinflammatory cytokines, concomitant with an altered cytokine profile of T lymphocytes. High plasma levels of tumor necrosis factor (TNF)-alpha are strongly associated with morbidity...... and mortality in elderly humans. However, the cellular source and mechanisms for the increased circulating TNF-alpha levels are unknown. OBJECTIVE: The aim of the present study was to investigate if high plasma levels of TNF-alpha are associated with increased production of TNF-alpha by T lymphocytes in elderly...... humans. METHODS: TNF-alpha production by CD4+ and CD8+ T lymphocytes was measured by flow cytometry following stimulation with phorbol 12-myristate 13-acetate and ionomycin in 28 young controls, 14, 81-year-olds and 25 centenarians. RESULTS: Plasma levels of TNF-alpha increased with increasing age...

  8. PREFACE: 12th High-Tech Plasma Processes Conference (HTPP-12)

    Science.gov (United States)

    Gleizes, Alain; Ghedini, Emanuele; Gherardi, Matteo; Sanibondi, Paolo; Dilecce, Giorgio

    2012-12-01

    The High-Tech Plasma Processes - 12th European Plasma Conference (HTPP-12) was held in Bologna (Italy) on 24-29 June 2012. The conference series started in 1990 as a thermal plasma conference and gradually expanded to include other topic fields as well. Now the High-Tech Plasma Processes - European Plasma Conference (HTPP) is a bi-annual international conference based in Europe with topics encompassing the whole area of plasma processing science. The aim of the conference is to bring different scientific communities together, facilitate the contacts between science, technology and industry and provide a platform for the exploration of both fundamental topics and new applications of plasmas. Thanks to the efforts of the conference chairman, Professor Vittorio Colombo and of the co-chair, Professor Piero Favia, a well balanced participation from both the communities of thermal and nonthermal plasma researchers was achieved; this resulted in just about 196 attendees from 39 countries, with 8 plenary and 15 invited talks, plus 50 oral and 140 poster contributions. This volume of Journal of Physics: Conference Series gathers papers from regular contributions of HTPP-12; each contribution submitted for publication has been peer reviewed and the Editors are very grateful to the referees for their careful support in improving the original manuscripts. In the end, 39 manuscripts were accepted for publication, covering different topics of plasma processing science: from plasma fundamentals and modelling to source design and process diagnostics, from nanomaterial synthesis to surface modification, from waste treatment to plasma applications in a liquid environment. It is an honour to present this volume of Journal of Physics: Conference Series and we deeply thank the authors for their enthusiastic and high-grade contribution. Finally, we would like to thank the conference chairmen, the members of the steering committee, the international scientific committee, the local

  9. PREFACE: 13th High-Tech Plasma Processes Conference (HTPP-2014)

    Science.gov (United States)

    2014-11-01

    The High-Tech Plasma Processes - 13th European Plasma Conference (HTPP-2014) was held in Toulouse (France) on 22-27 June 2014. The conference series started in 1990 as a thermal plasma conference and has gradually expanded to include other related topics. Now the High-Tech Plasma Processes - European Plasma Conference (HTPP) is an international conference organised in Europe every two years with topics encompassing the whole field of plasma processing science. The aim of the conference is to bring different scientific communities together, to facilitate contacts between science, technology and industry and to provide a platform for the exploration of both the fundamental topics and new applications of plasmas. For this edition of HTPP, as was the case for the last, we have acheived a well balanced participation from the communities of both thermal and non-thermal plasma researchers. 142 people from 17 countries attended the conference with the total number of contributions being 155, consisting of 8 plenary and 8 invited talks plus 51 oral and 88 poster contributions. We have received numerous papers corresponding to the contributions of HTPP-2014 that have been submitted for publication in this volume of Journal of Physics: Conference Series. Each submitted contribution has been peer reviewed (60 referees with at least two reviewing each paper) and the Editors are very grateful to the referees for their careful support in improving the original manuscripts. In total, 52 manuscripts have been accepted for publication covering a range of topics of plasma processing science from plasma fundamentals to process applications through to experiments, diagnostics and modelling. We have grouped the papers into the following 5 topics: - Arc-Materials Interaction and Metallurgy - Plasma Torches and Spraying - Synthesis of Powders and Nanomaterials - Deposition and Surface Treatment - Non-Equilibrium Plasmas We deeply thank the authors for their enthusiastic and high

  10. Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.

    Science.gov (United States)

    Newman-Tancredi, A; Nicolas, J P; Audinot, V; Gavaudan, S; Verrièle, L; Touzard, M; Chaput, C; Richard, N; Millan, M J

    1998-08-01

    This study examined the activity of chemically diverse alpha2 adrenoceptor ligands at recombinant human (h) and native rat (r) alpha2A adrenoceptors compared with 5-HT1A receptors. First, in competition binding experiments at h alpha2A and h5-HT1A receptors expressed in CHO cells, several compounds, including the antagonists 1-(2-pyrimidinyl)piperazine (1-PP), (+/-)-idazoxan, benalfocin (SKF 86466), yohimbine and RX 821,002, displayed preference for h alpha2A versus h5-HT1A receptors of only 1.4-, 3.6-, 4-, 10- and 11-fold, respectively (based on differences in pKi values). Clonidine, brimonidine (UK 14304), the benzopyrrolidine fluparoxan and the guanidines guanfacine and guanabenz exhibited intermediate selectivity (22- to 31-fold) for h alpha2A receptors. Only the antagonist atipamezole and the agonist dexmedetomidine (DMT) displayed high preference for alpha2 adrenoceptors (1290- and 91-fold, respectively). Second, the compounds were tested for their ability to induce h5-HT1A receptor-mediated G-protein activation, as indicated by the stimulation of [35S]GTPgammaS binding. All except atipamezole and RX 821,002 exhibited agonist activity, with potencies which correlated with their affinity for h5-HT1A receptors. Relative efficacies (Emax values) were 25-35% for guanabenz, guanfacine, WB 4101 and benalfocin, 50-65% for 1-PP, (+/-)-idazoxan and clonidine, and over 70% for fluparoxan, oxymetazoline and yohimbine (relative to 5-HT = 100%). Yohimbine-induced [35S]GTPgammaS binding was inhibited by the selective 5-HT1A receptor antagonist WAY 100,635. In contrast, RX 821,002 was the only ligand which exhibited antagonist activity at h5-HT1A receptors, inhibiting 5-HT-stimulated [35S]GTPgammaS binding. Atipamezole, which exhibited negligeable affinity for 5-HT1A receptors, was inactive. Third, the affinities for r alpha2A differed considerably from the affinities for h alpha2A receptors whereas the affinities for r5-HT1A differed much less from the affinities for h5-HT

  11. PREFACE: XVth International Conference on Calorimetry in High Energy Physics (CALOR2012)

    Science.gov (United States)

    Akchurin, Nural

    2012-12-01

    from Cells to Cities - a Physicist's Search for Quantitative, Unified Theories of Biological and Social Structure and Dynamics,' inspired many interesting questions from the audience both after the talk and throughout the week during informal conversations. Calorimetry is extremely diverse: many different techniques may be employed in building the detector and also in extracting information from it. The topics of the Calorimeter Techniques sessions included high-rate liquid argon calorimeters, SiPM sensors, highly granular digital calorimeters, new crystals, and beam test and simulation results. In these pages, you will find exciting and sometimes contradicting points of view expressed, for example about fully sampling hadronic calorimeters. A rare astronomical event, the Venus transit, coincided with the second day of the conference. The participants enjoyed viewing Venus' trail across the sun with a solar telescope (H-alpha line at 656 nm). In Santa Fe, the interior ingress was at 16:23:04 and reached center at 19:27:04. The last transit occurred in 2004, and the next one will happen in 2117. In 1627, Johannes Kepler published data about the planetary orbits that predicted that Venus would pass directly between earth and the sun in 1631. Unfortunately Kepler died in 1630 and apparently nobody recorded the 1631 transit. The first recorded observation of a transit was in 1638, which Kepler had not predicted. Later, Jeremiah Horracks, an English astronomer, realized Kepler had made an error in his calculations. It was not until the Venus transit observations of 1769 that scientists measured the distance from the earth to the sun to be 95 million miles (actually 93 million miles or 149.7 million kilometers) based on the 1716 triangulation suggestion from Edmund Halley (of comet fame). It's interesting to remember that before the 18th century, one of the most vexing scientific puzzles, not unlike today's Higgs boson quest, was 'How far away is the Sun?' Although natural

  12. Asilomar conference on managing complexity in high energy physics: A summary and renaming of the conference

    International Nuclear Information System (INIS)

    Nash, T.

    1987-02-01

    The complex aspects of high energy physics work are briefly described, and approaches to managing them are discussed. Management of software and data are covered. For managing complexity in experimental physics, the choice of building or buying processor systems is addressed and the issues of compatibility and standardization are discussed

  13. PREFACE: 23rd International Conference on High Pressure Science and Technology (AIRAPT-23)

    Science.gov (United States)

    Gupta, Satish C.

    2012-07-01

    The 23rd AIRAPT International Conference on High Pressure Science and Technology was held at Bhabha Atomic Research Centre, Mumbai, from 25-30 September 2011. This conference is part of the series of AIRAPT International Conferences which are held biennially. AIRAPT is an acronym for the French title which translates as 'International Association for the Advancement of High Pressure Science and Technology'. This was the second time the AIRAPT Conference was organized in India. The first was held 20 years ago at the National Aeronautical Laboratory, Bangalore in 1991. The 23rd Conference covered many important topics in the area of both static and dynamic high pressures including theoretical and experimental investigations on the response of materials under high pressures, new developments using neutron and synchrotron sources, investigations on superconductivity under high pressure, studies of geophysical and planetary sciences, biosciences, and the synthesis of new materials. The conference program included Bridgman award lecture, Jemieson award lecture, seven plenary talks, 85 invited talks, 83 oral presentations and about 195 posters. In all there were 372 presentations. 285 scientists from 19 countries participated in the conference. The countries represented included Austria, Canada, China, Estonia, France, Germany, India, Israel, Italy, Japan, Nepal, New Zealand, Poland, Russia, South Korea, Spain, Sweden, Switzerland, Turkey, UK, Ukraine and USA. Many new developments were presented, for example, measurement techniques using the new generation synchrotron sources, more powerful neutron sources and much brighter laser sources; integration of gas-gun with synchrotron source; the achievement of multi-megabar pressures in shock-less dynamic compressions; and capabilities to synthesize centimeter size diamonds with better quality. All these developments have opened up new opportunities for understanding the physics of materials under high pressures. I would like

  14. Alpha-ray spectrometry at high temperature by using a compound semiconductor detector.

    Science.gov (United States)

    Ha, Jang Ho; Kim, Han Soo

    2013-11-01

    The use of conventional radiation detectors in harsh environments is limited by radiation damage to detector materials and by temperature constraints. We fabricated a wide-band gap semiconductor radiation detector based on silicon carbide. All the detector components were considered for an application in a high temperature environment like a nuclear reactor core. The radiation response, especially to alpha particles, was measured using an (241)Am source at variable operating voltages at room temperature in the air. The temperature on detector was controlled from 30°C to 250°C. The alpha-particle spectra were measured at zero bias operation. Even though the detector is operated at high temperature, the energy resolution as a function of temperature is almost constant within 3.5% deviation. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. High throughput octal alpha/gamma spectrometer for low level bioassay estimations

    International Nuclear Information System (INIS)

    Bhasin, B.D.; Shirke, S.H.; Suri, M.M.; Vaidya, P.P.; Ghodgaonkar, M.D.

    1995-01-01

    The present paper describes the development of a high throughput octal alpha spectrometry system specially developed for the estimation of low levels of actinides in bioassay and environmental samples. The system processes simultaneously the outputs coming from eight independent detectors. It can be configured to simultaneously record low level alpha and gamma spectra. The high throughput is achieved by using a prioritised multiplexer router. The prioritised multiplexing and routing coupled with fast 8K ADC (conversion time 20 μsec) allow simultaneous acquisition of multiple spectra without any significant loss in counts. The dual (8K, 24bit) port memory facilitates easy online viewing of spectrum buildup. A menu driven user friendly software makes the operating system convenient to use. A specially developed software provides built-in routines for processing the spectra and estimating the isotopic activity. The interactive mode of software provides easy identification of isotopes compatible with the separation chemistry of different actinides. (author). 6 refs., 2 figs

  16. Status of high level and alpha bearing waste management in PNC

    International Nuclear Information System (INIS)

    Uematsu, Kunihiko

    1982-04-01

    For completing the nuclear fuel cycle in Japan, Power Reactor and Nuclear Fuel Development Corporation (PNC) has a role to promote the management of high level and alpha bearing wastes. For high level waste management, it is planned in Japan to initiate the operation of a vitrification pilot plant by 1987 for the development of the solidification process, and to make it possible to initiate trial disposal by 2015 for the development of geological disposal technology. In PNC, monolithic borosilicate glass was selected as the final form of solidification. Alpha bearing wastes have been produced in the mixed oxide fuel fabrication facility and the reprocessing plant in PNC; and the amount should increase considerably in the future in Japan. About these two areas of waste management, the policy and the research/development programs are described. (J.P.N.)

  17. Operation of a high-purity silicon diode alpha particle detector at 1. 4 K

    Energy Technology Data Exchange (ETDEWEB)

    Martoff, C.J.; Kaczanowicz, E. (Temple Univ., Philadelphia, PA (USA)); Neuhauser, B.J.; Lopez, E.; Zhang, Y. (San Francisco State Univ., CA (USA)); Ziemba, F.P. (Quantrad Corp. (USA))

    1991-03-01

    Detection of alpha particles at temperatures as low as 1.4 K was demonstrated using a specially fabricated Si diode. The diode was 475 mm{sup 2} by 0.280 mm thick, fabricated from high-purity silicon with degenerately doped contacts. This is an important step toward development of dual-mode (ionization plus phonon) silicon detectors for low energy radiation. (orig.).

  18. arXiv Proceedings, High-Precision $\\alpha_s$ Measurements from LHC to FCC-ee Geneva, Switzerland, October 2-13, 2015

    CERN Document Server

    d'Enterria, David; Alekhin, S.; Banfi, A.; Bethke, S.; Blümlein, J.; Chetyrkin, K.G.; Dissertori, G.; Garcia i Tormo, X.; Hoang, A.H.; Klasen, M.; Klijnsma, T.; Kluth, S.; Kneur, J.-L.; Kniehl, B.A.; Kolodrubetz, D.W.; Kühn, J.; Mackenzie, P.; Malaescu, B.; Mateu, V.; Mihaila, L.; Moch, S.; Mönig, K.; Pérez-Ramos, R.; Pich, A.; Pires, J.; Rabbertz, K.; Salam, G.P.; Sannino, F.; Soto i Riera, J.; Srebre, M.; Stewart, I.W.

    2015-01-01

    This document provides a writeup of all contributions to the workshop on "High precision measurements of $\\alpha_s$: From LHC to FCC-ee" held at CERN, Oct. 12--13, 2015. The workshop explored in depth the latest developments on the determination of the QCD coupling $\\alpha_s$ from 15 methods where high precision measurements are (or will be) available. Those include low-energy observables: (i) lattice QCD, (ii) pion decay factor, (iii) quarkonia and (iv) $\\tau$ decays, (v) soft parton-to-hadron fragmentation functions, as well as high-energy observables: (vi) global fits of parton distribution functions, (vii) hard parton-to-hadron fragmentation functions, (viii) jets in $e^\\pm$p DIS and $\\gamma$-p photoproduction, (ix) photon structure function in $\\gamma$-$\\gamma$, (x) event shapes and (xi) jet cross sections in $e^+e^-$ collisions, (xii) W boson and (xiii) Z boson decays, and (xiv) jets and (xv) top-quark cross sections in proton-(anti)proton collisions. The current status of the theoretical and experiment...

  19. Clinical and virological effects of high-dose recombinant interferon-alpha in disseminated AIDS-related Kaposi's sarcoma

    NARCIS (Netherlands)

    de Wit, R.; Schattenkerk, J. K.; Boucher, C. A.; Bakker, P. J.; Veenhof, K. H.; Danner, S. A.

    1988-01-01

    The effectiveness and antiretroviral activities of interferon-alpha in AIDS-related Kaposi's sarcoma was assessed in a non-randomised, phase-II clinical trial. 28 patients were treated with high-dose (27-36 MU) human recombinant interferon-alpha 2a subcutaneously every day for 8 weeks. In patients

  20. INTERACTION BETWEEN THE ADH AND ALPHA-GPDH LOCI IN DROSOPHILA-MELANOGASTER - ADULT SURVIVAL AT HIGH-TEMPERATURE

    NARCIS (Netherlands)

    OUDMAN, L; VANDELDEN, W; KAMPING, A; BIJLSMA, R

    The role of high temperature resistance in the world-wide cline of Adh and alpha-Gpdh allele frequencies of Drosophila melanogaster was investigated. Experimental strains were used with different combinations of Adh and alpha-Gpdh alleles but with similar genetic background. The survival time of

  1. Ultra-high-resolution alpha spectrometry for nuclear forensics and safeguards applications

    International Nuclear Information System (INIS)

    Bacrania, Minesh K.; Croce, Mark; Bond, Evelyn; Dry, Donald; Moody, W. Allen; Lamont, Stephen; Rabin, Michael; Rim, Jung; Smith, Audrey; Beall, James; Bennett, Douglas; Kotsubo, Vincent; Horansky, Robert; Hilton, Gene; Schmidt, Daniel; Ullom, Joel; Cantor, Robin

    2010-01-01

    We will present our work on the development of ultra-high-resolution detectors for alpha particle spectrometry. These detectors, based on superconducting transition-edge sensors, offer energy resolution that is five to ten times better than conventional silicon detectors. Using these microcalorimeter detectors, the isotopic composition of mixed-actinide samples can be determined rapidly without the need for actinide separation chemistry to isolate each element, or mass spectrometry to separate isotopic signatures that can not be resolved using traditional alpha spectrometry (e.g. Pu-239/Pu-240, or Pu-238/Am-241). This paper will cover the detector and measurement system, actinide source preparation, and the quantitative isotopic analysis of a number of forensics- and safeguards-relevant radioactive sources.

  2. Ionization and scintillation response of high-pressure xenon gas to alpha particles

    International Nuclear Information System (INIS)

    Álvarez, V; Cárcel, S; Cervera, A; Díaz, J; Ferrario, P; Gil, A; Gómez-Cadenas, J J; Borges, F I G; Conde, C A N; Fernandes, L M P; Freitas, E D C; Cebrián, S; Dafni, T; Gómez, H; Egorov, M; Gehman, V M; Goldschmidt, A; Esteve, R; Evtoukhovitch, P; Ferreira, A L

    2013-01-01

    High-pressure xenon gas is an attractive detection medium for a variety of applications in fundamental and applied physics. In this paper we study the ionization and scintillation detection properties of xenon gas at 10 bar pressure. For this purpose, we use a source of alpha particles in the NEXT-DEMO time projection chamber, the large scale prototype of the NEXT-100 neutrinoless double beta decay experiment, in three different drift electric field configurations. We measure the ionization electron drift velocity and longitudinal diffusion, and compare our results to expectations based on available electron scattering cross sections on pure xenon. In addition, two types of measurements addressing the connection between the ionization and scintillation yields are performed. On the one hand we observe, for the first time in xenon gas, large event-by-event correlated fluctuations between the ionization and scintillation signals, similar to that already observed in liquid xenon. On the other hand, we study the field dependence of the average scintillation and ionization yields. Both types of measurements may shed light on the mechanism of electron-ion recombination in xenon gas for highly-ionizing particles. Finally, by comparing the response of alpha particles and electrons in NEXT-DEMO, we find no evidence for quenching of the primary scintillation light produced by alpha particles in the xenon gas.

  3. High frequency of HIF-1 alpha overexpression in BRCA1 related breast cancer

    NARCIS (Netherlands)

    van der Groep, Petra; Bouter, Alwin; Menko, Fred H.; van der Wall, Elsken; van Diest, Paul J.

    2008-01-01

    Hypoxia is a hallmark of cancer. Hypoxia inducible factor-1 alpha (HIF-1 alpha) is the key regulator of the hypoxia response. HIF-1 alpha is overexpressed during sporadic breast carcinogenesis and correlated with poor prognosis. Little is known on the role of HIF-1 alpha in hereditary breast

  4. Direct-scanning alpha spectrometer for americium and plutonium contamination on highly-enriched uranium surfaces

    International Nuclear Information System (INIS)

    Ward, W.C.; Martinez, H.E.; Abeyta, C.L.; Morgan, A.N.; Nelson, T.O.

    1997-01-01

    Trace Pu 239 and Am 241 contamination on a surface whose alpha count is dominated by U 235 and U 234 decay has been successfully quantified by counting swipes in external alpha spectroscopy chambers. The swipe process, however, is labor intensive and subject to uncertainties in the swiping process as well as degraded spectral resolution due to the presence of the swipe material. A multichannel instrument for automated in situ measurements of interior and exterior contamination has been developed which incorporates a rotary table, 13 fixed ion-implanted silicon detectors, and spectroscopy electronics. Custom software was written to allow alpha spectrometer to function as a virtual instrument in the LabView environment. This system gives improved speed and resolution as well as a complete log of the location of areas of high surface contamination, a feature not practical to obtain by other methods, and one which opens the possibility of long term studies such as Pu outgrowth evaluation employing the instrument. The authors present performance data as well as system integration, calibration, control, and dynamic geometric efficiency calculations related to the design of this and next generation systems

  5. High-Velocity Ly(Alpha) Emission from SMR 1987A

    Science.gov (United States)

    Michael, Eli; McCray, Richard; Borkowski, Kazimierz J.; Pun, Chu S. J.; Sonneborn, George

    1998-01-01

    The high-velocity Ly(Alpha) emission from SN 1987A observed with the Space Telescope Imaging Spectrograph (STIS) evidently comes from a reverse shock formed where the outer envelope of SN 1987A strikes ionized gas inside the inner circumstellar ring. The observations can be explained by a simple kinematic model, in which the Ly(Alpha) emission comes from hydrogen atoms with radial velocity approximately 15,000 km s(exp -1) crossing a reverse shock in the shape of a slightly prolate ellipsoid with equatorial radius 4.8 x 10(exp 17) cm or approximately 80% of the distance to the inner surface of the inner ring. N v double Lambda 1239, 1243 emission, if present, has a net luminosity approximately less than 30% times that of the Ly(Alpha) emission. Future STIS observations should enable us to predict the time of impact with the inner ring and to determine unambiguously whether or not N v emission is present. These observations will offer a unique opportunity to probe the structure of SN 1987A's circumstellar environment and the hydrodynamics and kinetics of very fast shocks.

  6. Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis.

    Science.gov (United States)

    Mocellin, Simone; Pasquali, Sandro; Rossi, Carlo R; Nitti, Donato

    2010-04-07

    Based on previous meta-analyses of randomized controlled trials (RCTs), the use of interferon alpha (IFN-alpha) in the adjuvant setting improves disease-free survival (DFS) in patients with high-risk cutaneous melanoma. However, RCTs have yielded conflicting data on the effect of IFN-alpha on overall survival (OS). We conducted a systematic review and meta-analysis to examine the effect of IFN-alpha on DFS and OS in patients with high-risk cutaneous melanoma. The systematic review was performed by searching MEDLINE, EMBASE, Cancerlit, Cochrane, ISI Web of Science, and ASCO databases. The meta-analysis was performed using time-to-event data from which hazard ratios (HRs) and 95% confidence intervals (CIs) of DFS and OS were estimated. Subgroup and meta-regression analyses to investigate the effect of dose and treatment duration were also performed. Statistical tests were two-sided. The meta-analysis included 14 RCTs, published between 1990 and 2008, and involved 8122 patients, of which 4362 patients were allocated to the IFN-alpha arm. IFN-alpha alone was compared with observation in 12 of the 14 trials, and 17 comparisons (IFN-alpha vs comparator) were generated in total. IFN-alpha treatment was associated with a statistically significant improvement in DFS in 10 of the 17 comparisons (HR for disease recurrence = 0.82, 95% CI = 0.77 to 0.87; P < .001) and improved OS in four of the 14 comparisons (HR for death = 0.89, 95% CI = 0.83 to 0.96; P = .002). No between-study heterogeneity in either DFS or OS was observed. No optimal IFN-alpha dose and/or treatment duration or a subset of patients more responsive to adjuvant therapy was identified using subgroup analysis and meta-regression. In patients with high-risk cutaneous melanoma, IFN-alpha adjuvant treatment showed statistically significant improvement in both DFS and OS.

  7. PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP'09)

    Science.gov (United States)

    Gruntorad, Jan; Lokajicek, Milos

    2010-11-01

    The 17th International Conference on Computing in High Energy and Nuclear Physics (CHEP) was held on 21-27 March 2009 in Prague, Czech Republic. CHEP is a major series of international conferences for physicists and computing professionals from the worldwide High Energy and Nuclear Physics community, Computer Science, and Information Technology. The CHEP conference provides an international forum to exchange information on computing experience and needs for the community, and to review recent, ongoing and future activities. Recent conferences were held in Victoria, Canada 2007, Mumbai, India in 2006, Interlaken, Switzerland in 2004, San Diego, USA in 2003, Beijing, China in 2001, Padua, Italy in 2000. The CHEP'09 conference had 600 attendees with a program that included plenary sessions of invited oral presentations, a number of parallel sessions comprising 200 oral and 300 poster presentations, and an industrial exhibition. We thanks all the presenters, for the excellent scientific content of their contributions to the conference. Conference tracks covered topics on Online Computing, Event Processing, Software Components, Tools and Databases, Hardware and Computing Fabrics, Grid Middleware and Networking Technologies, Distributed Processing and Analysis and Collaborative Tools. The conference included excursions to Prague and other Czech cities and castles and a banquet held at the Zofin palace in Prague. The next CHEP conference will be held in Taipei, Taiwan on 18-22 October 2010. We would like thank the Ministry of Education Youth and Sports of the Czech Republic and the EU ACEOLE project for the conference support, further to commercial sponsors, the International Advisory Committee, the Local Organizing Committee members representing the five collaborating Czech institutions Jan Gruntorad (co-chair), CESNET, z.s.p.o., Prague Andrej Kugler, Nuclear Physics Institute AS CR v.v.i., Rez Rupert Leitner, Charles University in Prague, Faculty of Mathematics and

  8. 11. international conference on elastic and diffractive scattering: towards high energy frontiers

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This conference is held every 2 years. Every time these conferences on elastic and diffractive scattering adapt their content to the most recent experimental and theoretical results concerning not only quantum chromodynamics (QCD) but also other fields of particle physics where diffractive physics is present. This year, besides classical themes such as: -) forward scattering, -) total cross-sections, -) real parts, and -) pomeron and odderon, the participants have addressed many other subjects such as: -) LHC physics, -) non-perturbative approaches to high-energy scattering, -) the dipole model, -) small-x evolution, -) hard diffraction in QCD, -) nuclear shadowing, -) diffractive Higgs studies, -) spin effects, -) 4-quarks and 5-quarks, or -) B-physics.

  9. 11. international conference on elastic and diffractive scattering: towards high energy frontiers

    International Nuclear Information System (INIS)

    2005-01-01

    This conference is held every 2 years. Every time these conferences on elastic and diffractive scattering adapt their content to the most recent experimental and theoretical results concerning not only quantum chromodynamics (QCD) but also other fields of particle physics where diffractive physics is present. This year, besides classical themes such as: -) forward scattering, -) total cross-sections, -) real parts, and -) pomeron and odderon, the participants have addressed many other subjects such as: -) LHC physics, -) non-perturbative approaches to high-energy scattering, -) the dipole model, -) small-x evolution, -) hard diffraction in QCD, -) nuclear shadowing, -) diffractive Higgs studies, -) spin effects, -) 4-quarks and 5-quarks, or -) B-physics

  10. Keeping the Teacher at Arm's Length: Student Resistance in Writing Conferences in Two High School Classrooms

    Science.gov (United States)

    Consalvo, Annamary; Maloch, Beth

    2015-01-01

    The purpose of this paper is to explore a subset of findings taken from yearlong qualitative study of writing conferences in two diversely populated, urban high school classrooms. Drawing on multiple data sources, we used case study and discourse analytic methods to follow two focal students across the year in order to examine instructional and…

  11. The Utilisation of Highly Qualified Personnel. Venice Conference, 25th-27th October 1971.

    Science.gov (United States)

    Organisation for Economic Cooperation and Development, Paris (France).

    This document reports the highlights of an international conference designed to study the utilization of highly qualified personnel. Following the opening addresses by various participants, discussion documents and basic reports are presented. Four areas of concern include the state of employment and employment policy, the conditions and aims of…

  12. Simulation study for high resolution alpha particle spectrometry with mesh type collimator

    International Nuclear Information System (INIS)

    Park, Seunghoon; Kwak, Sungwoo; Kang, Hanbyeol; Shin, Jungki; Park, Iljin

    2014-01-01

    An alpha particle spectrometry with a mesh type collimator plays a crucial role in identifying specific radionuclide in a radioactive source collected from the atmosphere or environment. The energy resolution is degraded without collimation because particles with a high angle have a longer path to travel in the air. Therefore, collision with the background increases. The collimator can cut out particles which traveling at a high angle. As a result, an energy distribution with high resolution can be obtained. Therefore, the mesh type collimator is simulated for high resolution alpha particle spectrometry. In conclusion, the collimator can improve resolution. With collimator, the collimator is a role of cutting out particles with a high angle, so, low energy tail and broadened energy distribution can be reduced. The mesh diameter is found out as an important factor to control resolution and counting efficiency. Therefore, a target particle, for example, 235 U, can be distinguished by a detector with a collimator under a mixture of various nuclides, for example: 232 U, 238 U, and 232 Th

  13. HTR-2002: Proceedings of the conference on high temperature reactors

    International Nuclear Information System (INIS)

    2002-01-01

    High temperature reactors are considered as future inherently safe and efficient energy sources. The presentations covered all the relevant aspects of the existing HTGRs and/or helium cooled pebble bed reactors. They were sorted into 7 sessions: HTR Projects and Programmes; Fuel and Fuel Cycle; Physics and Neutronics; Thermohydraulic Calculation; Engineering, Design and Applications; Materials and Components; Safety and Licensing

  14. High prevalence of alpha-thalassemia among individuals with microcytosis and hypochromia without anemia

    Directory of Open Access Journals (Sweden)

    E. Borges

    2001-06-01

    Full Text Available In order to determine the contribution of alpha-thalassemia to microcytosis and hypochromia, 339 adult outpatients seen at Unicamp University Hospital (with the exception of the Clinical Hematology outpatient clinics, who showed normal hemoglobin (Hb levels and reduced mean corpuscular volume and mean corpuscular hemoglobin, were analyzed. Ninety-eight were Blacks (28.9% and 241 were Caucasians (71.1%. In all cases, Hb A2 and F levels were either normal or low. The most common deletional and nondeletional forms of alpha-thalassemia [-alpha3.7, -alpha4.2, --MED, -(alpha20.5, alphaHphIalpha, alphaNcoIalpha, aaNcoI and alphaTSAUDI] were investigated by PCR and restriction enzyme analyses. A total of 169 individuals (49.9% presented alpha-thalassemia: 145 (42.8% were heterozygous for the -alpha3.7 deletion (-alpha3.7/aa and 18 (5.3% homozygous (-alpha3.7/-alpha3.7, 5 (1.5% were heterozygous for the nondeletional form alphaHphIalpha (alphaHphIalpha/aa, and 1 (0.3% was a --MED carrier (--MED/aa. Among the Blacks, 56 (57.1% showed the -alpha3.7/aa genotype, whereas 12 (12.2% were -alpha3.7/-alpha3.7 and 1 (1.0% was an alphaHphIalpha carrier; among the Caucasians, 89 (36.9% were -alpha3.7/aa, 6 (2.5% had the -alpha3.7/-alpha3.7 genotype, 4 (1.7% presented the nondeletional form (alphaHphIalpha/aa, and 1 (0.4% was a --MED carrier. These results demonstrate that alpha-thalassemia, mainly through the -alpha3.7 deletion, is an important cause of microcytosis and hypochromia in individuals without anemia. These data are of clinical relevance since these hematological alterations are often interpreted as indicators of iron deficiency.

  15. High resolution microphotonic needle for endoscopic imaging (Conference Presentation)

    Science.gov (United States)

    Tadayon, Mohammad Amin; Mohanty, Aseema; Roberts, Samantha P.; Barbosa, Felippe; Lipson, Michal

    2017-02-01

    GRIN (Graded index) lens have revolutionized micro endoscopy enabling deep tissue imaging with high resolution. The challenges of traditional GRIN lenses are their large size (when compared with the field of view) and their limited resolution. This is because of the relatively weak NA in standard graded index lenses. Here we introduce a novel micro-needle platform for endoscopy with much higher resolution than traditional GRIN lenses and a FOV that corresponds to the whole cross section of the needle. The platform is based on polymeric (SU-8) waveguide integrated with a microlens micro fabricated on a silicon substrate using a unique molding process. Due to the high index of refraction of the material the NA of the needle is much higher than traditional GRIN lenses. We tested the probe in a fluorescent dye solution (19.6 µM Alexa Flour 647 solution) and measured a numerical aperture of 0.25, focal length of about 175 µm and minimal spot size of about 1.6 µm. We show that the platform can image a sample with the field of view corresponding to the cross sectional area of the waveguide (80x100 µm2). The waveguide size can in principle be modified to vary size of the imaging field of view. This demonstration, combined with our previous work demonstrating our ability to implant the high NA needle in a live animal, shows that the proposed system can be used for deep tissue imaging with very high resolution and high field of view.

  16. High-alpha band synchronization across frontal, parietal and visual cortex mediates behavioral and neuronal effects of visuospatial attention.

    Science.gov (United States)

    Lobier, Muriel; Palva, J Matias; Palva, Satu

    2018-01-15

    Visuospatial attention prioritizes processing of attended visual stimuli. It is characterized by lateralized alpha-band (8-14 Hz) amplitude suppression in visual cortex and increased neuronal activity in a network of frontal and parietal areas. It has remained unknown what mechanisms coordinate neuronal processing among frontoparietal network and visual cortices and implement the attention-related modulations of alpha-band amplitudes and behavior. We investigated whether large-scale network synchronization could be such a mechanism. We recorded human cortical activity with magnetoencephalography (MEG) during a visuospatial attention task. We then identified the frequencies and anatomical networks of inter-areal phase synchronization from source localized MEG data. We found that visuospatial attention is associated with robust and sustained long-range synchronization of cortical oscillations exclusively in the high-alpha (10-14 Hz) frequency band. This synchronization connected frontal, parietal and visual regions and was observed concurrently with amplitude suppression of low-alpha (6-9 Hz) band oscillations in visual cortex. Furthermore, stronger high-alpha phase synchronization was associated with decreased reaction times to attended stimuli and larger suppression of alpha-band amplitudes. These results thus show that high-alpha band phase synchronization is functionally significant and could coordinate the neuronal communication underlying the implementation of visuospatial attention. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. High speed intravascular photoacoustic imaging of atherosclerotic arteries (Conference Presentation)

    Science.gov (United States)

    Piao, Zhonglie; Ma, Teng; Qu, Yueqiao; Li, Jiawen; Yu, Mingyue; He, Youmin; Shung, K. Kirk; Zhou, Qifa; Kim, Chang-Seok; Chen, Zhongping

    2016-02-01

    Cardiovascular disease is the leading cause of death in the industrialized nations. Accurate quantification of both the morphology and composition of lipid-rich vulnerable atherosclerotic plaque are essential for early detection and optimal treatment in clinics. In previous works, intravascular photoacoustic (IVPA) imaging for detection of lipid-rich plaque within coronary artery walls has been demonstrated in ex vivo, but the imaging speed is still limited. In order to increase the imaging speed, a high repetition rate laser is needed. In this work, we present a high speed integrated IVPA/US imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A miniature catheter with 1.0 mm outer diameter was designed with a 200 μm multimode fiber and an ultrasound transducer with 45 MHz center frequency. The fiber was polished at 38 degree and enclosed in a glass capillary for total internal reflection. An optical/electrical rotary junction and pull-back mechanism was applied for rotating and linearly scanning the catheter to obtain three-dimensional imaging. Atherosclerotic rabbit abdominal aorta was imaged as two frame/second at 1725 nm. Furthermore, by wide tuning range of the laser wavelength from 1680 nm to 1770 nm, spectroscopic photoacoustic analysis of lipid-mimicking phantom and an human atherosclerotic artery was performed ex vivo. The results demonstrated that the developed IVPA/US imaging system is capable for high speed intravascular imaging for plaque detection.

  18. State of the art of D ampersand D Instrumentation Technology: Alpha counting in the presence of high background

    International Nuclear Information System (INIS)

    Dickerman, C.E.

    1995-08-01

    Discrimination of alpha activity in the presence of a high radiation background has been identified as an area of concern to be studied for D ampersand D applications. Upon evaluating the range of alpha detection needs for D ampersand D operations, we have expanded this study to address the operational concern of greatly expediting alpha counting of rough surfaces and rubble. Note that the term, ''rough surfaces'' includes a wide range of practical cases, including contaminated equipment and work surfaces. We have developed provisional applications requirements for instrumentation of this type; and we also have generated the scope of a program of instrument evaluation and testing, with emphasis on practical implementation. In order to obtain the full operational benefit of alpha discrimination in the presence of strong beta-gamma radiation background, the detection system must be capable of some form of remote or semi-remote operation in order to reduce operator exposure. We have identified a highly promising technique, the long-range alpha detector (LRAD), for alpha discrimination in the presence of high radiation background. This technique operates upon the principle of transporting alphaionized air to an ionization detector. A transport time within a few seconds is adequate. Neither the provisional requirements nor the evaluation and testing scope were expressly tailored to force the selection of a LRAD technology, and they could be used as a basis for studies of other promising technologies. However, a technology that remotely detects alpha-ionized air (e. g., LRAD) is a natural fit to the key requirements of rejection of high background at the survey location and operator protection. Also, LRAD appears to be valuable for D ampersand D applications as a means of greatly expediting surface alpha-activity surveys that otherwise would require performing time-consuming scans over surfaces of interest with alpha detector probes, and even more labor-intensive surface

  19. High resolution multiplexed functional imaging in live embryos (Conference Presentation)

    Science.gov (United States)

    Xu, Dongli; Zhou, Weibin; Peng, Leilei

    2017-02-01

    Fourier multiplexed fluorescence lifetime imaging (FmFLIM) scanning laser optical tomography (FmFLIM-SLOT) combines FmFLIM and Scanning laser optical tomography (SLOT) to perform multiplexed 3D FLIM imaging of live embryos. The system had demonstrate multiplexed functional imaging of zebrafish embryos genetically express Foster Resonant Energy Transfer (FRET) sensors. However, previous system has a 20 micron resolution because the focused Gaussian beam diverges quickly from the focused plane, makes it difficult to achieve high resolution imaging over a long projection depth. Here, we present a high-resolution FmFLIM-SLOT system with achromatic Bessel beam, which achieves 3 micron resolution in 3D deep tissue imaging. In Bessel-FmFLIM-SLOT, multiple laser excitation lines are firstly intensity modulated by a Michelson interferometer with a spinning polygon mirror optical delay line, which enables Fourier multiplexed multi-channel lifetime measurements. Then, a spatial light modulator and a prism are used to transform the modulated Gaussian laser beam to an achromatic Bessel beam. The achromatic Bessel beam scans across the whole specimen with equal angular intervals as sample rotated. After tomography reconstruction and the frequency domain lifetime analysis method, both the 3D intensity and lifetime image of multiple excitation-emission can be obtained. Using Bessel-FmFLIM-SLOT system, we performed cellular-resolution FLIM tomography imaging of live zebrafish embryo. Genetically expressed FRET sensors in these embryo will allow non-invasive observation of multiple biochemical processes in vivo.

  20. 13. TOPICAL CONFERENCE ON HIGH TEMPERATURE PLASMA DIAGNOSTICS SCIENTIFIC PROGRAM

    International Nuclear Information System (INIS)

    Barnes, C.

    2000-01-01

    Electron cyclotron emission (ECE) has been employed as a standard electron temperature profile diagnostic on many tokamaks and stellarators, but most magnetically confined plasma devices cannot take advantage of standard ECE diagnostics to measure temperature. They are either overdense, operating at high density relative to the magnetic field (e.g. ω pe >> (Omega) ce in a spherical torus) or they have insufficient density and temperature to reach the blackbody condition (τ > 2). Electron Bernstein waves (EBWs) are electrostatic waves which can propagate in overdense plasmas and have a high optical thickness at the electron cyclotron resonance layers, as a result of their large K i . This talk reports on measurements of EBW emission on the CDX-U spherical torus, where B 0 ∼ 2 kG, e > ∼ 10 13 cm -3 and T e ∼ 10 - 200 eV. Results will be presented for both direct detection of EBWs and for mode-converted EBW emission. The EBW emission was absolutely calibrated and compared to the electron temperature profile measured by a multi-point Thomson scattering diagnostic. Depending on the plasma conditions, the mode-converted EBW radiation temperature was found to be ≤ T e and the emission source was determined to be radially localized at the electron cyclotron resonance layer. A Langmuir triple probe was employed to measure changes in edge density profile in the vicinity of the upper hybrid resonance where the mode conversion of the EBWs is expected to occur. Changes in the mode conversion efficiency may explain the observation of mode-converted EBW radiation temperatures below T e . Initial results suggest EBW emission and EBW heating are viable concepts for plasmas where ω pe >> (Omega) ce

  1. The 3rd CARISMA international conference on medium and high temperature proton exchange membrane fuel cells: Three approaches to better platinum catalysts at biannual conference

    DEFF Research Database (Denmark)

    Jensen, Jens Oluf; Cleemann, Lars Nilausen; Li, Qingfeng

    2013-01-01

    exchange membrane fuel cells (PEMFCs) to be operated at intermediate and high temperatures. The conference series was initiated by the European CARISMA Coordination Action for Research on Intermediate and High Temperature Specialized Membrane Electrode Assemblies. The 2012 event in Copenhagen had around...

  2. High Affinity IgE-Fc Receptor alpha and gamma Subunit Interactions

    International Nuclear Information System (INIS)

    Rashid, A.; Housden, J. E. M.; Sabban, S.; Helm, B.

    2014-01-01

    Objective: To explore the relationships between the subunits (alpha, beta and gamma) of the high affinity IgE receptor (Fc and RI) and its ability to mediate transmembrane signaling. Study Design: Experimental study. Place and Duration of Study: Department of Molecular Biology and Biotechnology, University of Sheffield, UK, from 2008 to 2009. Methodology: The approach employed was to create a chimera (human alpha-gamma-gamma) using the extracellular (EC) domain of the human high affinity IgE receptor. The alpha subunit (huFc and RIalpha) of IgE receptor was spliced onto the rodent gamma TM and cytoplasmic domain (CD). This was transfected into the Rat Basophilic Leukemia cell line in order to assess the possibility of selectively activating cells transfected with this single pass construct for antigen induced mediator release. Results: The RBLs cell lines transfected with the huFc and RIalpha/gamma/gamma cDNA constructs were assessed for the cell surface expression of the huFc and RIalpha subunit and the response to the antigenic stimulus by looking for degranulation and intracellular Ca2+ mobilisation. The results obtained showed the absence of huFc and RIalpha subunit expression on the surface of transfected cells as seen by flowcytometric studies, beta-hexosaminidase assays and intracellular calcium mobilisation studies. Conclusion: In the present study the grounds for non-expression of huFc and RIalpha/gamma/gamma cDNA remains elusive but may be due to the fact that the human-rodent chimeric receptors are assembled differently than the endogenous rodent receptors as seen in study in which COS 7 cells were transfected with human/rat chimeric complexes. (author)

  3. The 8th International Conference on Highly Frustrated Magnetism (HFM 2016)

    Science.gov (United States)

    Gardner, J. S.; Kao, Y. J.

    2017-04-01

    The 8th International Conference on Highly Frustrated Magnetism 2016 (HFM 2016) took place between the 7th and 11th of September 2016 at the GIS Convention Center at National Taiwan University, Taipei, Taiwan. Over 260 participants from all over the world, attended the meeting making it the largest HFM to-date and revealing the impressive growth in the community since the original meeting in Waterloo, Canada where 80 participants attended. Preceding the meeting a school was held at the National Synchrotron Radiation Research Center to help those new to the field understand the material they were likely to see at HFM2016. Our thanks to the international speakers who attended this school John Chalker, Michel Kenzelmann, Philippe Mendels, Luigi Paolasini, Kirrily Rule, Yixi Su, Isao Watanabe and those from Taiwan W. T. Chen, Y-J, Kao, L. J. Chang and C. S. Ku, for their enlightening presentations. The HFM 2016 conference consisted of five plenary talks by H Takagi, B D Gaulin, L Balents, Y Tokura and S T Bramwell, 20 invited and 40 contributed presentations, and about 160 poster presentations from all aspects of theoretical and experimental frustrated magnetism. During the conference period, many stimulating discussions were held both inside and outside the conference room. Excursions to Taipei 101 and the National Palace Museum, as well as several organized dinners and receptions allowed the participants to initiate collaborations and discuss the hottest issues. The subjects covered in the conference included: · Quantum frustrated magnetism and spin liquids · Novel ordering of geometrically frustrated magnets · Frustration effect on the coupling to lattice, orbital and charge degrees of freedom · Exotic phenomena induced by macroscopic degeneracy · Field effect on frustrated magnetism etc. These proceeding represent a very small, but valuable contribution to the community. I hope you enjoy reading them. In view of the rapid growth of the field, it has been

  4. Determination of 239Pu/240Pu isotopic ratio by high resolution alpha-particle spectrometry

    International Nuclear Information System (INIS)

    Amoudry, F.; Burger, P.

    1983-05-01

    The development of passivated ion-implanted silicon detectors and of very thin alpha-particle sources improves the resolution of alpha-particle spectra and allows to separate energy pics up to now unseparate. The 239 Pu/ 240 Pu isotopic ratio of a mixture has been measured using the alpha spectrometry deconvolution code DEMO [fr

  5. Effective radiological contamination control and monitoring techniques in high alpha environments.

    Science.gov (United States)

    Funke, Kevin C

    2003-02-01

    In the decommissioning of a highly contaminated alpha environment, such as the one at Hanford's 233-S Plutonium Concentration Facility, one of the key elements of a successful radiological control program is an integrated safety approach. This approach begins with the job-planning phase where the scope of the work is described. This is followed by a brainstorming session involving engineering and craft to identify how to perform the work in a logical sequence of events. Once the brainstorming session is over, a Job Hazard Analysis is performed to identify any potential problems. Mockups are utilized to enable the craft to get hands on experience and provide feedback and ideas to make the job run smoother. Ideas and experience gained during mockups are incorporated into the task instruction. To assure appropriate data are used in planning and executing the job, our principal evaluation tools included lapel and workplace air sampling, plus continuous air monitors and frequent surveys to effectively monitor job progress. In this highly contaminated alpha environment, with contamination levels ranging from 0.3 Bq cm-2 to approximately 100,000 Bq cm-2 (2,000 dpm per 100 cm2 to approximately 600 million dpm per 100 cm2), with average working levels of 1,600-3,200 Bq cm-2 (10-20 million dpm per 100 cm2) without concomitant ambient radiation levels, control of the spread of contamination is key to keeping airborne levels As Low As Reasonably Achievable.

  6. Anti-alpha interferon immunization: safety and immunogenicity in asymptomatic HIV positive patients at high risk of disease progression.

    Science.gov (United States)

    Gringeri, A; Santagostino, E; Mannucci, P M; Siracusano, L; Marinoni, A; Criscuolo, M; Carcagno, M; Fall, L S; M'Bika, J P; Bizzini, B

    1995-05-01

    A randomized, placebo-controlled trial was designed to evaluate safety and immunogenicity of an anti-cytokine vaccine in high risk HIV-positive patients. This strategy was aimed to modulate the impaired cytokine regulation in AIDS. Twelve asymptomatic patients on antiretroviral therapy for at least 1 year and with CD4 cell counts between 100-300/mm3 were randomized to receive adjuvanted formol-inactivated interferon alpha-2a (IFN alpha) and continue the current antiretroviral treatment, whatever it was, or to receive the adjuvant alone and the current antiretroviral treatment. All patients received 4 i.m. injections monthly, followed by booster injections every 3 months. Clinical status, immunology and virology were monitored. Immune response to vaccination was evaluated in term of antibody detection (ELISA) and serum anti-IFN alpha neutralizing capacity. Only local discomfort and transient fever were reported. All vaccines except one showed increased levels of anti-IFN alpha Abs and developed serum IFN alpha neutralizing capacity. Viral load did not increase in vaccinees while it remained unchanged or even increased in placebo-treated patients. None of them showed HIV-related symptoms and all had their CD4 cell counts stabilized over 18 months, whereas 2 placebo-treated patients developed full-blow AIDS. In conclusion, anti-IFN alpha vaccine was safe and immunogenic. Stable clinical and immunological status over 18 months was observed in vaccinees coupled to increased serum IFN alpha neutralizing capacity.

  7. Correlations in the three-dimensional Lyman-alpha forest contaminated by high column density absorbers

    Science.gov (United States)

    Rogers, Keir K.; Bird, Simeon; Peiris, Hiranya V.; Pontzen, Andrew; Font-Ribera, Andreu; Leistedt, Boris

    2018-05-01

    Correlations measured in three dimensions in the Lyman-alpha forest are contaminated by the presence of the damping wings of high column density (HCD) absorbing systems of neutral hydrogen (H I; having column densities N(H I) > 1.6 × 10^{17} atoms cm^{-2}), which extend significantly beyond the redshift-space location of the absorber. We measure this effect as a function of the column density of the HCD absorbers and redshift by measuring three-dimensional (3D) flux power spectra in cosmological hydrodynamical simulations from the Illustris project. Survey pipelines exclude regions containing the largest damping wings. We find that, even after this procedure, there is a scale-dependent correction to the 3D Lyman-alpha forest flux power spectrum from residual contamination. We model this residual using a simple physical model of the HCD absorbers as linearly biased tracers of the matter density distribution, convolved with their Voigt profiles and integrated over the column density distribution function. We recommend the use of this model over existing models used in data analysis, which approximate the damping wings as top-hats and so miss shape information in the extended wings. The simple `linear Voigt model' is statistically consistent with our simulation results for a mock residual contamination up to small scales (|k| account for the effect of the highest column density absorbers on the smallest scales (e.g. |k| > 0.4 h Mpc^{-1} for small damped Lyman-alpha absorbers; HCD absorbers with N(H I) ˜ 10^{21} atoms cm^{-2}). However, these systems are in any case preferentially removed from survey data. Our model is appropriate for an accurate analysis of the baryon acoustic oscillations feature. It is additionally essential for reconstructing the full shape of the 3D flux power spectrum.

  8. Interferon alpha 2 maintenance therapy may enable high rates of treatment discontinuation in chronic myeloid leukemia.

    Science.gov (United States)

    Burchert, A; Saussele, S; Eigendorff, E; Müller, M C; Sohlbach, K; Inselmann, S; Schütz, C; Metzelder, S K; Ziermann, J; Kostrewa, P; Hoffmann, J; Hehlmann, R; Neubauer, A; Hochhaus, A

    2015-06-01

    A minority of chronic myeloid leukemia (CML) patients is capable of successfully discontinuing imatinib. Treatment modalities to increase this proportion are currently unknown. Here, we assessed the role of interferon alpha 2a (IFN) on therapy discontinuation in a previously reported cohort of 20 chronic phase CML patients who were treated upfront with IFN alpha plus imatinib followed by IFN monotherapy to maintain cytogenetic or molecular remission (MR) after imatinib discontinuation. After a median follow-up of 7.9 years (range, 5.2-12.2), relapse-free survival was 73% (8/11 patients) and 84% (5/6 patients) for patients who discontinued imatinib in major MR (MMR) and MR4/MR4.5, respectively. Ten patients discontinued IFN after a median of 4.5 years (range, 0.24-9.3). After a median of 2.8 years (range, 0.7-5.1), nine of them remain in ongoing treatment-free remission with MR5 (n=6) and MR4.5 (n=3). The four patients who still administer IFN are in stable MR5, MR4.5, MR4, and MMR, respectively. In conclusion, an IFN/imatinib induction treatment followed by a temporary IFN maintenance therapy may enable a high rate of treatment discontinuation in CML patients in at least MMR when stopping imatinib.

  9. Monte Carlo treatment planning and high-resolution alpha-track autoradiography for neutron capture therapy

    Energy Technology Data Exchange (ETDEWEB)

    Zamenhof, R.G.; Lin, K.; Ziegelmiller, D.; Clement, S.; Lui, C.; Harling, O.K.

    Monte Carlo simulations of thermal neutron flux distributions in a mathematical head model have been compared to experimental measurements in a corresponding anthropomorphic gelatin-based head phantom irradiated by a thermal neutron beam as presently available at the MITR-II Research Reactor. Excellent agreement between Monte Carlo and experimental measurements has encouraged us to employ the Monte Carlo simulation technique to approach treatment planning problems in neutron capture therapy. We have also implemented a high-resolution alpha-track autoradiography technique originally developed in our laboratory at MIT. Initial autoradiograms produced by this technique meet our expectations in terms of the high resolution available and the ability to etch tracks without concommitant destruction of stained tissue. Our preliminary results with computer-aided track distribution analysis indicate that this approach is very promising in being able to quantify boron distributions in tissue at the subcellular level with a minimum amount of operator effort necessary.

  10. International Conference on Modern Mathematical Methods and High Performance Computing in Science and Technology

    CERN Document Server

    Srivastava, HM; Venturino, Ezio; Resch, Michael; Gupta, Vijay

    2016-01-01

    The book discusses important results in modern mathematical models and high performance computing, such as applied operations research, simulation of operations, statistical modeling and applications, invisibility regions and regular meta-materials, unmanned vehicles, modern radar techniques/SAR imaging, satellite remote sensing, coding, and robotic systems. Furthermore, it is valuable as a reference work and as a basis for further study and research. All contributing authors are respected academicians, scientists and researchers from around the globe. All the papers were presented at the international conference on Modern Mathematical Methods and High Performance Computing in Science & Technology (M3HPCST 2015), held at Raj Kumar Goel Institute of Technology, Ghaziabad, India, from 27–29 December 2015, and peer-reviewed by international experts. The conference provided an exceptional platform for leading researchers, academicians, developers, engineers and technocrats from a broad range of disciplines ...

  11. New Trends in high-energy physics (experiment, phenomenology, theory). Proceedings of the International Conference

    International Nuclear Information System (INIS)

    Bogolyubov, P.N.; Bugrij, G.V.; Jenkovszky, L.L.

    2001-01-01

    The subject of 'New Trends in High-Energy Physics' conference has been gradually extended (the number of participants still remain limited), now including: elastic and diffractive scattering of hadrons and nuclei, deep inelastic scattering and multiparticle dynamics, collective properties of the strongly interacting matter, heavy flavours and hadron spectroscopy, duality, strings and confinement, the standard model (and beyond), advances in quantum field theory, as well as new physics at future colliders

  12. PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP 2012)

    Science.gov (United States)

    Ernst, Michael; Düllmann, Dirk; Rind, Ofer; Wong, Tony

    2012-12-01

    The International Conference on Computing in High Energy and Nuclear Physics (CHEP) was held at New York University on 21- 25 May 2012. CHEP is a major series of international conferences for physicists and computing professionals from the High Energy and Nuclear Physics community and related scientific and technical fields. The CHEP conference provides a forum to exchange information on computing progress and needs for the community, and to review recent, ongoing and future activities. CHEP conferences are held at roughly 18-month intervals, alternating between Europe, Asia, the Americas and other parts of the world. Recent CHEP conferences have been held in Taipei, Taiwan (2010); Prague, Czech Republic (2009); Victoria, Canada (2007); Mumbai, India (2006); Interlaken, Switzerland (2004); San Diego, United States (2003); Beijing, China (2001); Padova, Italy (2000). CHEP 2012 was organized by Brookhaven National Laboratory (BNL) and co-sponsored by New York University. The organizational structure for CHEP consists of an International Advisory Committee (IAC) which sets the overall themes of the conference, a Program Organizing Committee (POC) that oversees the program content, and a Local Organizing Committee (LOC) that is responsible for local arrangements (lodging, transportation and social events) and conference logistics (registration, program scheduling, conference site selection and conference proceedings). There were over 500 attendees with a program that included plenary sessions of invited speakers, a number of parallel sessions comprising around 125 oral and 425 poster presentations and industrial exhibitions. We thank all the presenters for the excellent scientific content of their contributions to the conference. Conference tracks covered topics on Online Computing, Event Processing, Distributed Processing and Analysis on Grids and Clouds, Computer Facilities, Production Grids and Networking, Software Engineering, Data Stores and Databases and

  13. PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP 2010)

    Science.gov (United States)

    Lin, Simon C.; Shen, Stella; Neufeld, Niko; Gutsche, Oliver; Cattaneo, Marco; Fisk, Ian; Panzer-Steindel, Bernd; Di Meglio, Alberto; Lokajicek, Milos

    2011-12-01

    The International Conference on Computing in High Energy and Nuclear Physics (CHEP) was held at Academia Sinica in Taipei from 18-22 October 2010. CHEP is a major series of international conferences for physicists and computing professionals from the worldwide High Energy and Nuclear Physics community, Computer Science, and Information Technology. The CHEP conference provides an international forum to exchange information on computing progress and needs for the community, and to review recent, ongoing and future activities. CHEP conferences are held at roughly 18 month intervals, alternating between Europe, Asia, America and other parts of the world. Recent CHEP conferences have been held in Prauge, Czech Republic (2009); Victoria, Canada (2007); Mumbai, India (2006); Interlaken, Switzerland (2004); San Diego, California(2003); Beijing, China (2001); Padova, Italy (2000) CHEP 2010 was organized by Academia Sinica Grid Computing Centre. There was an International Advisory Committee (IAC) setting the overall themes of the conference, a Programme Committee (PC) responsible for the content, as well as Conference Secretariat responsible for the conference infrastructure. There were over 500 attendees with a program that included plenary sessions of invited speakers, a number of parallel sessions comprising around 260 oral and 200 poster presentations, and industrial exhibitions. We thank all the presenters, for the excellent scientific content of their contributions to the conference. Conference tracks covered topics on Online Computing, Event Processing, Software Engineering, Data Stores, and Databases, Distributed Processing and Analysis, Computing Fabrics and Networking Technologies, Grid and Cloud Middleware, and Collaborative Tools. The conference included excursions to various attractions in Northern Taiwan, including Sanhsia Tsu Shih Temple, Yingko, Chiufen Village, the Northeast Coast National Scenic Area, Keelung, Yehliu Geopark, and Wulai Aboriginal Village

  14. Determination of alpha-Tocopherol (vitamin E) in irradiated garlic by high performance liquid chromatography (HPLC); Determinacao de alpha-tocoferol em alho irradiado utilizando cromatografia liquida de alta frequencia (CLAE)

    Energy Technology Data Exchange (ETDEWEB)

    Rios, Magda Dias Goncalves; Penteado, Marilene de Vuono Camargo [Sao Paulo Univ., SP (Brazil). Faculdade de Ciencias Farmaceuticas. Dept. de Alimentos e Nutricao Experimental]. E-mail: riosmagda@hotmail.com

    2003-02-01

    The effects of {sup 60}Co ionizing radiations in doses of 0, 75, 100, 150, 200 and 250Gy on garlic, upon the {alpha}-tocopherol concentration were studied. The {alpha}-tocopherol contents were established by high performance liquid chromatography (HPLC), after direct hexane extraction from the garlic samples. The {alpha}-tocopherol was determined through normal phase column, and mobile phase was composed by hexane: iso-propyl alcohol (99:01 v/v), with 2mL/min flow rate and fluorescence detector. It is statistically shown that an irradiation dose of up to 150 Gy does not affect the garlic {alpha}-tocopherol content. (author)

  15. High-temperature effect of hydrogen on sintered alpha-silicon carbide

    Science.gov (United States)

    Hallum, G. W.; Herbell, T. P.

    1986-01-01

    Sintered alpha-silicon carbide was exposed to pure, dry hydrogen at high temperatures for times up to 500 hr. Weight loss and corrosion were seen after 50 hr at temperatures as low as 1000 C. Corrosion of SiC by hydrogen produced grain boundary deterioration at 1100 C and a mixture of grain and grain boundary deterioration at 1300 C. Statistically significant strength reductions were seen in samples exposed to hydrogen for times greater than 50 hr and temperatures above 1100 C. Critical fracture origins were identified by fractography as either general grain boundary corrision at 1100 C or as corrosion pits at 1300 C. A maximum strength decrease of approximately 33 percent was seen at 1100 and 1300 C after 500 hr exposure to hydrogen. A computer assisted thermodynamic program was also used to predict possible reaction species of SiC and hydrogen.

  16. Beams '96. Proceedings of the 11th international conference on high power particle beams. Vol. I

    International Nuclear Information System (INIS)

    Jungwirth, K.; Ullschmied, J.

    1996-01-01

    The Proceedings contain the full texts of 60 orals and 243 poster papers presented at the Conference. The scientific programme of the conference covered the physics and technology of intense beams of charged particles, from basic experimental and theoretical problems of beam generation, transport and interaction with various media, up to beam and pulsed power applications in science and in industry. The breakdown of the papers by main topical groups is as follows: electron beams, beam-plasma systems, high-power microwaves (62), imploding liners, z-pinches, plasma foci (53), pulsed power technology and its applications (53), ion beams and ICF (41), industrial applications of electron and ion beams (36), radiation sources (23), diagnostics (14), and others (21). (J.U.)

  17. Beams `96. Proceedings of the 11th international conference on high power particle beams. Vol. I

    Energy Technology Data Exchange (ETDEWEB)

    Jungwirth, K.; Ullschmied, J. [eds.

    1997-12-31

    The Proceedings contain the full texts of 60 orals and 243 poster papers presented at the Conference. The scientific programme of the conference covered the physics and technology of intense beams of charged particles, from basic experimental and theoretical problems of beam generation, transport and interaction with various media, up to beam and pulsed power applications in science and in industry. The breakdown of the papers by main topical groups is as follows: electron beams, beam-plasma systems, high-power microwaves (62), imploding liners, z-pinches, plasma foci (53), pulsed power technology and its applications (53), ion beams and ICF (41), industrial applications of electron and ion beams (36), radiation sources (23), diagnostics (14), and others (21). (J.U.).

  18. Research Area 4.1 Nano- and Bio-Electronics: Lester Eastman Conference on High-Performance Devices

    Science.gov (United States)

    2017-06-02

    significantly lower. Moreover, wells containing MoS2 on the polyimide film had a large amount of cells growing on the material, further indicating high ...SECURITY CLASSIFICATION OF: 1. REPORT DATE (DD-MM-YYYY) 4. TITLE AND SUBTITLE 13. SUPPLEMENTARY NOTES 12. DISTRIBUTION AVAILIBILITY STATEMENT 6...Research Area 4.1 Nano- and Bio-Electronics: Lester Eastman Conference on High -Performance Devices The 2016 IEEE Lester Eastman Conference of High

  19. 16th international conference on the physics of highly charged ions

    Science.gov (United States)

    Fritzsche, Stephan; Stöhlker, Thomas; Surzhykov, Andrey

    2013-09-01

    This volume contains the proceedings of the 16th International Conference on the Physics of Highly Charged Ions (HCI 2012) held at the Ruprecht-Karls University in Heidelberg, Germany, 2-7 September 2012 (figure 1). This conference has been part of a biannual conference series that was started in Stockholm in 1982 and, since then, has been organized at various places around the world, with recent venues in Belfast (UK, 2006), Tokyo (Japan, 2008) and Shanghai (China, 2010). The physics of highly charged ions (HCI) is a rapidly developing and attractive field of research with impact upon many other research disciplines. Apart from fundamental studies on the structure and dynamics of matter in extreme fields, or the search for physics beyond the standard model, detailed knowledge about the properties and behavior of HCI is crucial for other areas, from astro- and solar physics to hot plasma and fusion research to extreme ultra-violet and ion lithography, or even to medical research, to name just a few. In fusion research, for example, of whether tokamak, stellarator or confinement fusion facilities, most models and diagnostics deeply rely on the understanding of HCI and the (theoretical) prediction of accurate atomic data for these systems. In life science, moreover, ion therapy or the laser acceleration of ions and electrons may help save and improve the quality of life in the future. Many of these and further topics are addressed in these proceedings. After 30 years, the HCI conference series, and especially the meeting in Heidelberg, is appreciated much as a key forum for bringing together senior experts with students, young researchers and scientists from related disciplines who make use and give back impact upon the research with HCI. More than 250 scientists from 23 countries participated in HCI 2012 and presented the current status of the field. About one third of them were post-graduate students, showing that the field attracts many young and talented

  20. Advances in high pressure science and technology: proceedings of the fourth national conference on high pressure science and technology

    International Nuclear Information System (INIS)

    Yousuf, Mohammad; Subramanian, N.; Govinda Rajan, K.

    1997-09-01

    The proceedings of the fourth National Conference on High Pressure Science and Technology covers a wide area of research and development activities in the field of high pressure science and technology, broadly classified into the following themes: mechanical behaviour of materials; instrumentation and methods in high pressure research; pressure calibration, standards and safety aspects; phase transitions; shock induced reactions; mineral science, geophysics, geochemistry and planetary sciences; optical, electronic and transport properties; synthesis of materials; soft condensed matter physics and liquid crystals; computational methods in high pressure research. Papers relevant to INIS are indexed separately

  1. Abstracts of The First Polish-US Conference on High Temperature Superconductivity

    International Nuclear Information System (INIS)

    1995-01-01

    The current problems in high temperature superconductivity science have been presented at the conference. The two main topics have been mostly represented: superconducting material research and fundamental physical research on superconductivity mechanisms. Superconducting material preparation, chemical composition, magnetic and electrical properties of different type of high temperature superconductors, material structure and its influence on superconducting properties and related problems were included in the first of the general topics. In the range of second general topic of the two listed above, many theoretical models being applied for explanation of superconductivity mechanism in different systems up and below transition temperature were presented

  2. CALOR2012 XVth International Conference on Calorimetry in High Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Akchurin, Nural .

    2015-05-04

    The International Conferences on Calorimetry in High Energy Physics, or the CALOR series, have always been where the calorimeter experts come together to review the state of calorimetry and bring forth new ideas every two years. The fteenth conference, CALOR2012, in Santa Fe was no exception. Although they were built roughly a decade ago, we are now witnessing the exceptional power of the LHC calorimeters and the crucial role they have been playing in the discovery of the 125 GeV Higgs-like boson. As we ruminate on the coming generation of experiments at the next (linear) collider and on the upgrades at the LHC, we are heartened by the substantial advances we made in calorimetry in the last decade. These advances will certainly help uncover new physics in the years to come, not only at colliders but also in astroparticle experiments that take advantage of natural elements such as air, water, and ice. The proceedings were published by the IOP in Journal of Physics, Vol 404 2011. The conference web site is calor2012.ttu.edu.

  3. Proceedings of the International Conference on Applications of High Precision Atomic and Nuclear Methods

    International Nuclear Information System (INIS)

    Olariu, Agata; Stenstroem, Kristina; Hellborg, Ragnar

    2005-01-01

    This volume presents the Proceedings of the International Conference on Applications of High Precision Atomic and Nuclear Methods, held in Neptun, Romania from 2nd to 6th of September 2002. The conference was organized by The Center of Excellence of the European Commission: Inter-Disciplinary Research and Applications based on Nuclear and Atomic Physics (IDRANAP) from Horia Hulubei National Institute for Physics and Nuclear Engineering, IFIN-HH, Bucharest-Magurele, Romania. The meeting gathered 66 participants from 25 different laboratories in 11 countries, namely: Belgium, Bulgaria, France, Germany, Hungary, Poland, Portugal, Romania, Slovakia and Sweden. Non European delegate came from Japan. The topics covered by the conference were as follows: - Environment: air, water and soil pollution, pollution with heavy elements and with radioisotopes, bio-monitoring (10 papers); - Radionuclide metrology (10 papers); - Ion beam based techniques for characterization of materials surface, ERDA, PIXE, PIGE, computer simulations, materials modifications, wear, corrosion (10 papers) ; - Accelerator Mass Spectrometry and applications in environment, archaeology, and medicine (7 papers); - Application of neutron spectrometry in condensed matter (1 paper); - Advanced techniques, facilities and applications (11). Seventeen invited speakers covered through overview talks the main parts of these topics. The book contains the overview talks, oral contributions and poster contributions

  4. Quantitative digital image analysis of chromogenic assays for high throughput screening of alpha-amylase mutant libraries.

    Science.gov (United States)

    Shankar, Manoharan; Priyadharshini, Ramachandran; Gunasekaran, Paramasamy

    2009-08-01

    An image analysis-based method for high throughput screening of an alpha-amylase mutant library using chromogenic assays was developed. Assays were performed in microplates and high resolution images of the assay plates were read using the Virtual Microplate Reader (VMR) script to quantify the concentration of the chromogen. This method is fast and sensitive in quantifying 0.025-0.3 mg starch/ml as well as 0.05-0.75 mg glucose/ml. It was also an effective screening method for improved alpha-amylase activity with a coefficient of variance of 18%.

  5. Simulations of alpha parameters in a TFTR DT supershot with high fusion power

    International Nuclear Information System (INIS)

    Budny, R.V.; Bell, M.G.; Janos, A.C.

    1995-07-01

    A TFTR supershot with a plasma current of 2.5 MA, neutral beam heating power of 33.7 MW, and a peak DT fusion power of 7.5 MW is studied using the TRANSP plasma analysis code. Simulations of alpha parameters such as the alpha heating, pressure, and distributions in energy and v parallel /v are given. The effects of toroidal ripple and mixing of the fast alpha particles during the sawteeth observed after the neutral beam injection phase are modeled. The distributions of alpha particles on the outer midplane are peaked near forward and backward v parallel /v. Ripple losses deplete the distributions in the vicinity of v parallel /v ∼-0.4. Sawtooth mixing of fast alpha particles is computed to reduce their central density and broaden their width in energy

  6. Investigation of high-alpha lateral-directional control power requirements for high-performance aircraft

    Science.gov (United States)

    Foster, John V.; Ross, Holly M.; Ashley, Patrick A.

    1993-01-01

    Designers of the next-generation fighter and attack airplanes are faced with the requirements of good high angle-of-attack maneuverability as well as efficient high speed cruise capability with low radar cross section (RCS) characteristics. As a result, they are challenged with the task of making critical design trades to achieve the desired levels of maneuverability and performance. This task has highlighted the need for comprehensive, flight-validated lateral-directional control power design guidelines for high angles of attack. A joint NASA/U.S. Navy study has been initiated to address this need and to investigate the complex flight dynamics characteristics and controls requirements for high angle-of-attack lateral-directional maneuvering. A multi-year research program is underway which includes groundbased piloted simulation and flight validation. This paper will give a status update of this program that will include a program overview, description of test methodology and preliminary results.

  7. Proceedings of the GPU computing in high-energy physics conference 2014 GPUHEP2014

    International Nuclear Information System (INIS)

    Bonati, Claudio; D'Elia, Massimo; Lamanna, Gianluca; Sozzi, Marco

    2015-06-01

    The International Conference on GPUs in High-Energy Physics was held from September 10 to 12, 2014 at the University of Pisa, Italy. It represented a larger scale follow-up to a set of workshops which indicated the rising interest of the HEP community, experimentalists and theorists alike, towards the use of inexpensive and massively parallel computing devices, for very diverse purposes. The conference was organized in plenary sessions of invited and contributed talks, and poster presentations on the following topics: - GPUs in triggering applications - Low-level trigger systems based on GPUs - Use of GPUs in high-level trigger systems - GPUs in tracking and vertexing - Challenges for triggers in future HEP experiments - Reconstruction and Monte Carlo software on GPUs - Software frameworks and tools for GPU code integration - Hard real-time use of GPUs - Lattice QCD simulation - GPUs in phenomenology - GPUs for medical imaging purposes - GPUs in neutron and photon science - Massively parallel computations in HEP - Code parallelization. ''GPU computing in High-Energy Physics'' attracted 78 registrants to Pisa. The 38 oral presentations included talks on specific topics in experimental and theoretical applications of GPUs, as well as review talks on applications and technology. 5 posters were also presented, and were introduced by a short plenary oral illustration. A company exhibition was hosted on site. The conference consisted of 12 plenary sessions, together with a social program which included a banquet and guided excursions around Pisa. It was overall an enjoyable experience, offering an opportunity to share ideas and opinions, and getting updated on other participants' work in this emerging field, as well as being a valuable introduction for newcomers interested to learn more about the use of GPUs as accelerators for scientific progress on the elementary constituents of matter and energy.

  8. Proceedings of the GPU computing in high-energy physics conference 2014 GPUHEP2014

    Energy Technology Data Exchange (ETDEWEB)

    Bonati, Claudio; D' Elia, Massimo; Lamanna, Gianluca; Sozzi, Marco (eds.)

    2015-06-15

    The International Conference on GPUs in High-Energy Physics was held from September 10 to 12, 2014 at the University of Pisa, Italy. It represented a larger scale follow-up to a set of workshops which indicated the rising interest of the HEP community, experimentalists and theorists alike, towards the use of inexpensive and massively parallel computing devices, for very diverse purposes. The conference was organized in plenary sessions of invited and contributed talks, and poster presentations on the following topics: - GPUs in triggering applications - Low-level trigger systems based on GPUs - Use of GPUs in high-level trigger systems - GPUs in tracking and vertexing - Challenges for triggers in future HEP experiments - Reconstruction and Monte Carlo software on GPUs - Software frameworks and tools for GPU code integration - Hard real-time use of GPUs - Lattice QCD simulation - GPUs in phenomenology - GPUs for medical imaging purposes - GPUs in neutron and photon science - Massively parallel computations in HEP - Code parallelization. ''GPU computing in High-Energy Physics'' attracted 78 registrants to Pisa. The 38 oral presentations included talks on specific topics in experimental and theoretical applications of GPUs, as well as review talks on applications and technology. 5 posters were also presented, and were introduced by a short plenary oral illustration. A company exhibition was hosted on site. The conference consisted of 12 plenary sessions, together with a social program which included a banquet and guided excursions around Pisa. It was overall an enjoyable experience, offering an opportunity to share ideas and opinions, and getting updated on other participants' work in this emerging field, as well as being a valuable introduction for newcomers interested to learn more about the use of GPUs as accelerators for scientific progress on the elementary constituents of matter and energy.

  9. Theses of reports 'V Conference of high energy physics, nuclear physics and accelerators'

    International Nuclear Information System (INIS)

    Dovbnya, A.N.

    2007-01-01

    Nucleus structure study in the reactions on the charged particles; application of the nuclear and physical methods in the adjacent science fields; study and development of accelerators and accumulators of charged particles; basic research in an effort to develop the nuclear and physical methods for the nuclear power needs, medicine and industry; computed engineering in the physical studies; basic research of interaction processes of ultrarelativistic particles with monocrystals and substance; physics of detectors are submitted in proceedings of V Conference on High Energy Physics

  10. Book of abstracts of the 9th Conference on High Energy Physics, Nuclear Physics and Accelerators

    International Nuclear Information System (INIS)

    Dovbnya, A.N.

    2011-01-01

    The conference is devoted to the fundamental investigations at intermediate and high energies; also, the nuclear structure in reactions with charged particles; application of nuclear-physical methods to associated fields; investigation and development of accelerators, and of charged particles storage rings; the fundamental investigation and development of nuclear physical methods as applied in atomic energetics, medicine and industry; an application of the computer technologies for physical studies; fundamental investigations of processes of the ultrarelativistic particle interactions with monocrystals and matter; and physics of detectors.

  11. Improved synthesis with high yield and increased molecular weight of poly(alpha,beta-malic acid) by direct polycondensation.

    Science.gov (United States)

    Kajiyama, Tetsuto; Kobayashi, Hisatoshi; Taguchi, Tetsushi; Kataoka, Kazunori; Tanaka, Junzo

    2004-01-01

    The development of synthetic biodegradable polymers, such as poly(alpha-hydroxy acid), is particularly important for constructing medical devices, including scaffolds and sutures, and has attracted growing interest in the biomedical field. Here, we report a novel approach to preparing high molecular weight poly(malic acid) (HMW--PMA) as a biodegradable and bioabsorbable water-soluble polymer. We investigated in detail the reaction conditions for the simple direct polycondensation of l-malic acid, including the reaction times, temperatures, and catalysts. The molecular weight of synthesized alpha,beta-PMA is dependent on both the reaction temperature and time. The optimum reaction condition to obtain alpha,beta-PMA by direct polycondensation using tin(II) chloride as a catalyst was thus determined to be 110 degrees C for 45 h with a molecular weight of 5300. The method for alpha,beta-PMA synthesis established here will facilitate production of alpha,beta-PMA of various molecular weights, which may have a potential utility as biomaterials.

  12. PREFACE: 21st International Conference on Computing in High Energy and Nuclear Physics (CHEP2015)

    Science.gov (United States)

    Sakamoto, H.; Bonacorsi, D.; Ueda, I.; Lyon, A.

    2015-12-01

    The International Conference on Computing in High Energy and Nuclear Physics (CHEP) is a major series of international conferences intended to attract physicists and computing professionals to discuss on recent developments and trends in software and computing for their research communities. Experts from the high energy and nuclear physics, computer science, and information technology communities attend CHEP events. This conference series provides an international forum to exchange experiences and the needs of a wide community, and to present and discuss recent, ongoing, and future activities. At the beginning of the successful series of CHEP conferences in 1985, the latest developments in embedded systems, networking, vector and parallel processing were presented in Amsterdam. The software and computing ecosystem massively evolved since then, and along this path each CHEP event has marked a step further. A vibrant community of experts on a wide range of different high-energy and nuclear physics experiments, as well as technology explorer and industry contacts, attend and discuss the present and future challenges, and shape the future of an entire community. In such a rapidly evolving area, aiming to capture the state-of-the-art on software and computing through a collection of proceedings papers on a journal is a big challenge. Due to the large attendance, the final papers appear on the journal a few months after the conference is over. Additionally, the contributions often report about studies at very heterogeneous statuses, namely studies that are completed, or are just started, or yet to be done. It is not uncommon that by the time a specific paper appears on the journal some of the work is over a year old, or the investigation actually happened in different directions and with different methodologies than originally presented at the conference just a few months before. And by the time the proceedings appear in journal form, new ideas and explorations have

  13. PREFACE: 15th International Conference on the Physics of Highly Charged Ions

    Science.gov (United States)

    Zou, Yaming; Hutton, Roger

    2011-07-01

    This issue contains papers presented at the 15th International Conference on the Physics of Highly Charged Ions, HCI2010. The conference was held at Fudan University, Shanghai, 29 August-3 September 2010. HCI is a biannual conference series going back to the very first conference held in Stockholm, Sweden in 1982. Previous editions in this millennium were held in Berkeley, USA, 2000; Caen, France, 2002; Vilnius, Lithuania, 2004; Belfast, UK, 2006, and Tokyo, Japan, 2008. The physics of highly charged ions, HCIs, is of great interest due to their key role in testing quantum electrodynamics in strong fields, and possible testing of parity non-conservation. However, HCIs also play crucial roles in the physics of hot plasmas, for example those produced in tokamak fusion devices and in inertial confinement fusion experiments. Much of the diagnostics of matter under such extreme environments relies very heavily on high quality atomic data of HCIs. The field of x-ray astronomy hinges almost entirely on the use of spectral lines from HCIs to provide information from distant astrophysical plasmas and objects. Given these fundamental interests and the current rapid developments in fusion and x-ray astronomy, it is clear that the physics of HCIs is a rich area of research with strong and important connections to many important subfields of physics. New application areas of HCI physics are also under development: two examples are (a) to provide 13.5 nm—and later half of this wavelength—radiation for lithography and (b) applications in medical research. The need for high quality atomic data of HCIs is as important now as it has ever been. HCI2010 was attended by over 200 scientists from around 20 countries; see the following table. Over 70 of the participants were students, which is very encouraging for the future of HCI related physics. The academic programme was organized based on the suggestions from the International Advisory Board, and consisted of six review lectures

  14. PREFACE: 14th International Conference on the Physics of Highly Charged Ions (HCI 2008)

    Science.gov (United States)

    Azuma, Toshiyuki; Nakamura, Nobuyuki; Yamada, Chikashi

    2009-07-01

    This volume contains the Proceedings of the 14th International Conference on the Physics of Highly Charged Ions (HCI2008), held at the University of Electro-Communications, Chofu, Tokyo, Japan from 1-5 September 2008. This series of conferences began in Stockholm, Sweden in 1982 and has since been held every other year; in Oxford, UK (1984), Groningen, the Netherlands (1986), Grenoble, France (1988), Giessen, Germany (1990), Manhattan, Kansas, USA (1992), Vienna, Austria (1994), Omiya, Japan (1996), Bensheim, Germany (1998), Berkeley, USA (2000), Caen, France (2002), Vilnius, Lithuania (2004) and Belfast, UK (2006). Highly charged ions (HCI), which are defined as highly ionized (i.e. positively charged atomic) ions here, mainly exist in hot plasmas such as the solar corona and fusion plasmas. It is true that its importance in plasma physics has driven researchers to the spectroscopic studies of HCIs, but the spectroscopy of few-electron ions is not only important for plasmas but also interesting for fundamental atomic physics. Electrons moving fast near a heavy nucleus give a suitable system to test the fundamental atomic theory involving relativistic and quantum electro-dynamic effects in a strong field. Also, the huge potential energy of a HCI induces drastic reaction in the interaction with matter. This unique property of HCIs, coupled with the recent development of efficient ion sources, is opening the possibility to utilize them in new technologies in the field such as nano-fabrication, surface analysis, medical physics, and so on. Hence, this conference is recognized as a valuable gathering place for established practitioners and also for newcomers; we exchange information, we are introduced to the subject itself, and to unexpected interfaces with other fields. On 31 August, the day before the opening of HCI2008, we welcomed the delegates at the university's restaurant—and we were greeted with an unusually heavy summer shower! The conference then opened on

  15. High-Speed Rail for Central and Eastern European Countries: A Conference Report

    Directory of Open Access Journals (Sweden)

    Jandová Monika

    2016-09-01

    Full Text Available The European transport strategy promotes the role of railways and expects that the key role in passenger transport should be played by high-speed rail (HSR. Although the core network of high-speed lines has already been built and is operating in Western Europe, there has been little coverage so far in Central and Eastern Europe (CEE. The aim of the conferenceHigh-Speed Rail for CEE Countries” that took place in Prague in June 2016 was to put together academics, policy-makers, and practitioners interested in HSR and to formulate recommendations for CEE countries based on West European countries’ experience. Based on the conference presentations and subsequent discussion, the following conclusions were formulated. Firstly, there are many crucial differences in national HSR build-up and operation, which means that former experience of Western Europe is not directly applicable to CEE countries. Secondly, in comparing presentations discussing experiences in France, Britain, Italy, and Germany, it was concluded that the German approach-upgrading existing lines where possible and only building new lines for bottleneck sections-was the most likely appropriate solution in CEE. Lastly, CEE has the additional problem of many border crossings, with a reduction of traffic in comparison with purely domestic routes, and this effect has to be taken into account.

  16. Analysis of Limit Cycle Oscillation/Transonic High Alpha Flow Visualization. Part 1: Discussion

    National Research Council Canada - National Science Library

    Cunningham, Atlee M

    1998-01-01

    ...) at low alpha conditions typical of transonic LCO flows with and without tip stores. Laser light sheet/water vapor techniques were used to illuminate the flows, and video recording was used to obtain the data...

  17. Analysis of Limit Cycle Oscillation/Transonic High ALPHA Flow Visualization. Part 2 Stationary Model Data

    National Research Council Canada - National Science Library

    Cunningham, Atlee M

    1998-01-01

    ...) at low alpha conditions typical of transonic LCO flows with and without tip stores. Laser light sheet/water vapor techniques were used to illuminate the flows, and video recording was used to obtain the data...

  18. Analysis of Limit Cycle Oscillation/Transonic High Alpha Flow Visualization

    National Research Council Canada - National Science Library

    Cunningham, Atlee M

    1997-01-01

    ...) at low alpha condition typical of transonic LCO flows with and without tip stores. Laser light sheet/water vapor techniques were used to illuminate the flows, and video recording was used to obtain the data...

  19. Analysis of Limit Cycle Oscillation/Transonic High ALPHA Flow Visualization. Part 3 Oscillating Model Data

    National Research Council Canada - National Science Library

    Cunningham, Atlee M

    1998-01-01

    ...) at low alpha conditions typical of transonic LCO flows with and without tip stores. Laser light sheet/water vapor techniques were used to illuminate the flows, and video recording was used to obtain the data...

  20. Measurement of natural radioactivity in chemical fertilizer and agricultural soil: evidence of high alpha activity.

    Science.gov (United States)

    Ghosh, Dipak; Deb, Argha; Bera, Sukumar; Sengupta, Rosalima; Patra, Kanchan Kumar

    2008-02-01

    People are exposed to ionizing radiation from the radionuclides that are present in different types of natural sources, of which phosphate fertilizer is one of the most important sources. Radionuclides in phosphate fertilizer belonging to 232Th and 238U series as well as radioisotope of potassium (40K) are the major contributors of outdoor terrestrial natural radiation. The study of alpha activity in fertilizers, which is the first ever in West Bengal, has been performed in order to determine the effect of the use of phosphate fertilizers on human health. The data have been compared with the alpha activity of different types of chemical fertilizers. The measurement of alpha activity in surface soil samples collected from the cultivated land was also performed. The sampling sites were randomly selected in the cultivated land in the Midnapore district, which is the largest district in West Bengal. The phosphate fertilizer is widely used for large agricultural production, mainly potatoes. The alpha activities have been measured using solid-state nuclear track detectors (SSNTD), a very sensitive detector for alpha particles. The results show that alpha activity of those fertilizer and soil samples varies from 141 Bq/kg to 2,589 Bq/kg and from 109 Bq/kg to 660 Bq/kg, respectively. These results were used to estimate environmental radiation exposure on human health contributed by the direct application of fertilizers.

  1. High-Alpha Research Vehicle Lateral-Directional Control Law Description, Analyses, and Simulation Results

    Science.gov (United States)

    Davidson, John B.; Murphy, Patrick C.; Lallman, Frederick J.; Hoffler, Keith D.; Bacon, Barton J.

    1998-01-01

    This report contains a description of a lateral-directional control law designed for the NASA High-Alpha Research Vehicle (HARV). The HARV is a F/A-18 aircraft modified to include a research flight computer, spin chute, and thrust-vectoring in the pitch and yaw axes. Two separate design tools, CRAFT and Pseudo Controls, were integrated to synthesize the lateral-directional control law. This report contains a description of the lateral-directional control law, analyses, and nonlinear simulation (batch and piloted) results. Linear analysis results include closed-loop eigenvalues, stability margins, robustness to changes in various plant parameters, and servo-elastic frequency responses. Step time responses from nonlinear batch simulation are presented and compared to design guidelines. Piloted simulation task scenarios, task guidelines, and pilot subjective ratings for the various maneuvers are discussed. Linear analysis shows that the control law meets the stability margin guidelines and is robust to stability and control parameter changes. Nonlinear batch simulation analysis shows the control law exhibits good performance and meets most of the design guidelines over the entire range of angle-of-attack. This control law (designated NASA-1A) was flight tested during the Summer of 1994 at NASA Dryden Flight Research Center.

  2. The flavoprotein Tah18-dependent NO synthesis confers high-temperature stress tolerance on yeast cells

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, Akira; Kawahara, Nobuhiro [Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192 (Japan); Takagi, Hiroshi, E-mail: hiro@bs.naist.jp [Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192 (Japan)

    2013-01-04

    Highlights: Black-Right-Pointing-Pointer NO is produced from L-arginine in response to elevated temperature in yeast. Black-Right-Pointing-Pointer Tah18 was first identified as the yeast protein involved in NO synthesis. Black-Right-Pointing-Pointer Tah18-dependent NO synthesis confers tolerance to high-temperature on yeast cells. -- Abstract: Nitric oxide (NO) is a ubiquitous signaling molecule involved in the regulation of a large number of cellular functions. In the unicellular eukaryote yeast, NO may be involved in stress response pathways, but its role is poorly understood due to the lack of mammalian NO synthase (NOS) orthologues. Previously, we have proposed the oxidative stress-induced L-arginine synthesis and its physiological role under stress conditions in yeast Saccharomyces cerevisiae. Here, our experimental results indicated that increased conversion of L-proline into L-arginine led to NO production in response to elevated temperature. We also showed that the flavoprotein Tah18, which was previously reported to transfer electrons to the Fe-S cluster protein Dre2, was involved in NO synthesis in yeast. Gene knockdown analysis demonstrated that Tah18-dependent NO synthesis confers high-temperature stress tolerance on yeast cells. As it appears that such a unique cell protection mechanism is specific to yeasts and fungi, it represents a promising target for antifungal activity.

  3. 6th International Conference on Hard and Electromagnetic Probes of High-Energy Nuclear Collisions

    CERN Document Server

    2014-01-01

    One of the premier meetings in the field of high-energy nuclear physics, the Hard Probes conference series brings together the experimental and theoretical communities interested in the hard and electromagnetic observables related to nuclear matter at extreme temperatures and densities. Prior to the conference, the University of Cape Town will host a summer school for young physicists in the field. High energy nuclear physics focuses on the science of a trillion degrees. These temperatures were last seen in nature a microsecond after the Big Bang, but mankind recreates them thousands of times a second in particle accelerators such as CERN's Large Hadron Collider and BNL's Relativistic Heavy Ion Collider. At these temperatures, 100,000 times hotter than the center of the sun, the strong force is dominant, and we hope to learn about the fundamental and non-trivial emergent many-body dynamics of the quarks and gluons that make up 99% of the mass of the visible universe. We anticipate the usual format for the H...

  4. The flavoprotein Tah18-dependent NO synthesis confers high-temperature stress tolerance on yeast cells

    International Nuclear Information System (INIS)

    Nishimura, Akira; Kawahara, Nobuhiro; Takagi, Hiroshi

    2013-01-01

    Highlights: ► NO is produced from L-arginine in response to elevated temperature in yeast. ► Tah18 was first identified as the yeast protein involved in NO synthesis. ► Tah18-dependent NO synthesis confers tolerance to high-temperature on yeast cells. -- Abstract: Nitric oxide (NO) is a ubiquitous signaling molecule involved in the regulation of a large number of cellular functions. In the unicellular eukaryote yeast, NO may be involved in stress response pathways, but its role is poorly understood due to the lack of mammalian NO synthase (NOS) orthologues. Previously, we have proposed the oxidative stress-induced L-arginine synthesis and its physiological role under stress conditions in yeast Saccharomyces cerevisiae. Here, our experimental results indicated that increased conversion of L-proline into L-arginine led to NO production in response to elevated temperature. We also showed that the flavoprotein Tah18, which was previously reported to transfer electrons to the Fe–S cluster protein Dre2, was involved in NO synthesis in yeast. Gene knockdown analysis demonstrated that Tah18-dependent NO synthesis confers high-temperature stress tolerance on yeast cells. As it appears that such a unique cell protection mechanism is specific to yeasts and fungi, it represents a promising target for antifungal activity.

  5. PREFACE: 17th International Conference on the Physics of Highly Charged Ions

    Science.gov (United States)

    2015-01-01

    The 17th edition of the International Conference on the Physics of Highly Charged Ions (HCI 2014) was held in San Carlos de Bariloche, in the southern region of Argentina known as Patagonia, from August 31 to September 5, 2014. This meeting corresponds to a series of HCI conferences, which has been held every other year since 1982 in cities in Europe, USA, Japan and China. This was the first time that the conference took place in Latin America. This edition was organized by a Local Committee made up of physicists mainly from the cities of Bariloche and Rosario and also from Buenos Aires and Bahía Blanca, all sites where research on Atomic Collisions is developed. The conference was attended by delegates coming from 18 countries, more that 23% of whom were women. The field of highly charged ions has seen in recent years a promising evolution originating from bold progress in theory and significant advances in experimental techniques. The HCI conferences aim at bringing together experimentalists and theoreticians from as wide a range of fields as, for instance, Fundamental Aspects, Structure and Spectroscopy, Collisions with Electrons, Ions, Atoms and Molecules, Interaction with Clusters, Surfaces and Solids, Interactions with Photons and Plasmas, Strong Field Processes, and Production, Experimental Developments and Applications. The Scientific Programme, selected by an International Advisory Board, included 5 Review Lectures, 11 Progress Reports, 1 Local Report and 24 Special Reports. In addition, the results of 132 contributed works were presented as poster communications and a Public Lecture on 'The wonders of the Southern Skies' was delivered by an Argentinean expert. Thus, a wide range of subjects comprising a balanced mix of topics was covered throughout the course of the conference. The HCI 2014 was a resounding success for the international and local communities, from both the scientific and social aspects, considering that the attendees and accompanying

  6. Reduction in high blood tumor necrosis factor-alpha levels after manipulative therapy in 2 cervicogenic headache patients.

    Science.gov (United States)

    Ormos, Gábor; Mehrishi, J N; Bakács, Tibor

    2009-09-01

    This case report discusses the treatment of 2 patients with cervicogenic headache (CHA) attending the Outpatient Clinic of the Hungarian National Institute for Rheumatology and Physiotherapy (Budapest, Hungary) and reviews the pathophysiology, therapeutic strategy, and problems associated with the treatment of CHA. Patient 1 was a 27-year-old female who sustained a whiplash injury. A sharp, shooting headache developed, readily induced, and aggravated by just bending the neck backward or by turning her head. Magnetic resonance imaging revealed a disk protrusion at C4-C5 pressing the anterior cerebrospinal space. Patient 2 was a 62-year-old female who sustained a whiplash injury; her cervical movements became restricted, which precipitated headaches. Magnetic resonance imaging revealed a paramedian disk hernia between the C4 and C5 vertebrae that intruded into the right ventral cerebrospinal space. After 4 weeks of manipulative therapy for patient 1, both active and passive range of motion returned to normal, and the high tumor necrosis factor-alpha (TNF-alpha) level (63 pg/mL) was substantially reduced (28 pg/mL). Patient 2 was started on manipulative therapy twice a week for 4 weeks; after 2 months, the patient became symptom-free, and high TNF-alpha level (72 pg/mL) was reduced greatly (35 pg/mL). Two patients with whiplash injury and disk herniation developed CHA associated with very high TNF-alpha levels. After manipulative therapy, these patients became symptom-free, and their TNF-alpha levels decreased substantially.

  7. Proceedings of the 34th International Conference in High Energy Physics (ICHEP08), Philadelphia, PA, 2008

    International Nuclear Information System (INIS)

    Lockyer, Nigel S.; Smith, A.J. Stewart

    2008-01-01

    In 2004 a team from the University of Pennsylvania, Princeton University, and the Institute for Advanced Study proposed to host the 2008 International Conference on High Energy Physics (ICHEP) on the campus of the University of Pennsylvania in Philadelphia. The proposal was approved later that year by the C-11 committee of the International Union of Pure and Applied Physics. The Co-Chairs were Nigel S. Lockyer (U. Penn/TRIUMF) and A.J. Stewart Smith (Princeton); Joe Kroll of U. Penn served as Deputy Chair from 2007 on. Highlights of the proposal included 1. greatly increased participation of young scientists, women scientists, and graduate students 2. new emphasis on formal theory 3. increased focus on astrophysics and cosmology 4. large informal poster session (170 posters) in prime time 5. convenient, contiguous venues for all sessions and lodging 6. landmark locations for the reception and banquet. The conference program consisted of three days of parallel sessions and three days of plenary talks.

  8. High specific activity N-Acetyl-3{sup H}-{alpha}-Aspartyl- L-Glutamic at micro mole scale; Sintesis de N-Acetil-3{sup H}- {alpha} -Aspartil-Glutamico a escala de Micromoles

    Energy Technology Data Exchange (ETDEWEB)

    Suarez, C

    1984-07-01

    High specific activity N-Acetyl-3{sup H}- {alpha} -Aspartyl-I-Glutamic acid at micro mole scale in prepared acetylating L- {alpha} -Aspartyl-L-glutamic with 3{sup H}-acetic anhydride in re distilled toluene. The product le purified through cationic and anionic columns. The radiochemical purity as determined by thin-layer chromatography is greater then 99% at the time preparation. (Author) 5 refs.

  9. PREFACE: XIII International Conference on Calorimetry in High Energy Physics (CALOR 2008)

    Science.gov (United States)

    Livan, Michele

    2009-07-01

    The XIII International Conference on Calorimetry in High Energy Physics was held in Pavia, Italy, 26-30 May 2008, picking up the baton from the 2006 Conference in Chicago. The Conference took place in the unique environment of the Theresian Room of the University Library. The attendees were surrounded by over 40 000 books of general interest and culture, and had the opportunity to see precious volumes written by such people as Galileo, Volta and Faraday. The Workshop brought together more than 120 participants, including senior scientists as well as young physicists, confirming the central and ever-growing role of calorimeters in modern particle physics. The development of these detectors, as stressed by Professor Klaus Pretzl in his lectio magistralis, has made it possible to explore new frontiers in physics, and the present scenario is no exception to this rule. With the LHC experiments almost completely installed and ready to take data, the Conference was an ideal chance to review the status of the different projects, whose development has been followed and discussed throughout the entire Calor series, and to show that they are capable of meeting the design specifications. Other highlights were the performance and physics results of calorimeters installed in currently operating experiments. In the session on astrophysics and neutrinos, the contributions confirmed the key role of calorimeters in this sector and demonstrated their growing application even beyond the field of accelerator physics. Considerable time was devoted to the state-of-the-art techniques in the design and operation of the detectors, while the session on simulation addressed the importance of a thorough understanding of the shower development to meet the demanding requirements of present experiments. Finally, on the R&D side, the particle flow and dual read-out concepts confronted the challenges issued by the next generation of experiments. This complex material was reviewed in 83

  10. Cryogenic microcalorimeter system for ultra-high resolution alpha-particle spectrometry

    International Nuclear Information System (INIS)

    Rabin, Michael W.; Hoover, Andrew S.; Bacrania, Minesh K.; Croce, Mark P.; Hoteling, N.J.; Lamont, S.P.; Plionis, A.A.; Dry, D.E.; Ullom, J.N.; Bennett, D.A.; Horansky, R.; Kotsubo, V.; Cantor, R.

    2009-01-01

    Microcalorimeters have been shown to yield unsurpassed energy resolution for alpha spectrometry, up to 1.06 keV FWHM at 5.3 MeV. These detectors use a superconducting transition-edge sensor (TES) to measure the temperature change in an absorber from energy deposited by an interacting alpha particle. Our system has four independent detectors mounted inside a liquid nitrogen/liquid helium cryostat. An adiabatic demagnetization refrigerator (ADR) cools the detector stage to its operating temperature of 80 mK. Temperature regulation with ∼15 uK peak-to-peak variation is achieved by PID control of the ADR. The detectors are voltage-biased, and the current signal is amplified by a commercial SQUID readout system and digitized for further analysis, This paper will discuss design and operation of our microcalorimeter alpha spectrometer, and will show recent results.

  11. Cryogenic Microcalorimeter System for Ultra-High Resolution Alpha-Particle Spectrometry

    Science.gov (United States)

    Croce, M. P.; Bacrania, M. K.; Hoover, A. S.; Rabin, M. W.; Hoteling, N. J.; LaMont, S. P.; Plionis, A. A.; Dry, D. E.; Ullom, J. N.; Bennett, D. A.; Horansky, R. D.; Kotsubo, V.; Cantor, R.

    2009-12-01

    Microcalorimeters have been shown to yield unsurpassed energy resolution for alpha spectrometry, up to 1.06 keV FWHM at 5.3 MeV. These detectors use a superconducting transition-edge sensor (TES) to measure the temperature change in an absorber from energy deposited by an interacting alpha particle. Our system has four independent detectors mounted inside a liquid nitrogen/liquid helium cryostat. An adiabatic demagnetization refrigerator (ADR) cools the detector stage to its operating temperature of 80 mK. Temperature regulation with ˜15-μK peak-to-peak variation is achieved by PID control of the ADR. The detectors are voltage-biased, and the current signal is amplified by a commercial SQUID readout system and digitized for further analysis. This paper will discuss design and operation of our microcalorimeter alpha-particle spectrometer, and will show recent results.

  12. The amino-terminal 200 amino acids of the plasma membrane Na+,K+-ATPase alpha subunit confer ouabain sensitivity on the sarcoplasmic reticulum Ca(2+)-ATPase.

    OpenAIRE

    Ishii, T; Takeyasu, K

    1993-01-01

    Cardiac glycosides such as G-strophanthin (ouabain) bind to and inhibit the plasma membrane Na+,K(+)-ATPase but not the sarcoplasmic reticulum (SR) Ca(2+)-ATPase, whereas thapsigargin specifically blocks the SR Ca(2+)-ATPase. The chimera [n/c]CC, in which the amino-terminal amino acids Met1 to Asp162 of the SR Ca(2+)-ATPase (SERCA1) were replaced with the corresponding portion of the Na+,K(+)-ATPase alpha 1 subunit (Met1 to Asp200), retained thapsigargin- and Ca(2+)-sensitive ATPase activity,...

  13. The Texas A and M student branch's annual high school teachers' conference

    International Nuclear Information System (INIS)

    Wood, A.; Clements, M.

    1991-01-01

    To quote the American Nuclear Society (ANS) Student Constitution, the objective of a student branch is the advancement of science and engineering relating to the atomic nucleus, and of allied science and arts. The Texas A and M University (TAMU) student chapter has extended this objective to that of promoting a better understanding of the nuclear sciences by the general public. The student branch has attempted to reach these objectives by sponsoring a variety of activities designed to motivate and interest individuals to become more aware of nuclear technology and its benefits. These activities are directed toward fellow college students, high school teachers and students, and the surrounding community. One of the largest and most important activities organized by the TAMU student branch is the annual student conference

  14. SCinet Architecture: Featured at the International Conference for High Performance Computing,Networking, Storage and Analysis 2016

    Energy Technology Data Exchange (ETDEWEB)

    Lyonnais, Marc; Smith, Matt; Mace, Kate P.

    2017-02-06

    SCinet is the purpose-built network that operates during the International Conference for High Performance Computing,Networking, Storage and Analysis (Super Computing or SC). Created each year for the conference, SCinet brings to life a high-capacity network that supports applications and experiments that are a hallmark of the SC conference. The network links the convention center to research and commercial networks around the world. This resource serves as a platform for exhibitors to demonstrate the advanced computing resources of their home institutions and elsewhere by supporting a wide variety of applications. Volunteers from academia, government and industry work together to design and deliver the SCinet infrastructure. Industry vendors and carriers donate millions of dollars in equipment and services needed to build and support the local and wide area networks. Planning begins more than a year in advance of each SC conference and culminates in a high intensity installation in the days leading up to the conference. The SCinet architecture for SC16 illustrates a dramatic increase in participation from the vendor community, particularly those that focus on network equipment. Software-Defined Networking (SDN) and Data Center Networking (DCN) are present in nearly all aspects of the design.

  15. Purification, enzymatic characterization, and nucleotide sequence of a high-isoelectric-point alpha-glucosidase from barley malt

    DEFF Research Database (Denmark)

    Frandsen, T P; Lok, F; Mirgorodskaya, E

    2000-01-01

    in the transition state complex. Mass spectrometry of tryptic fragments assigned the 92-kD protein to a barley cDNA (GenBank accession no. U22450) that appears to encode an alpha-glucosidase. A corresponding sequence (HvAgl97; GenBank accession no. AF118226) was isolated from a genomic phage library using a c......High-isoelectric-point (pI) alpha-glucosidase was purified 7, 300-fold from an extract of barley (Hordeum vulgare) malt by ammonium sulfate fractionation, ion-exchange, and butyl-Sepharose chromatography. The enzyme had high activity toward maltose (k(cat) = 25 s(-1)), with an optimum at pH 4...

  16. Treatment of solid waste highly contaminated by alpha emitters: Low-temperature impact crushing, leaching and incineration

    International Nuclear Information System (INIS)

    Bertolotti, G.; Vigreux, B.; Caillol, A.; Koehly, G.

    1987-01-01

    Reprocessing plants, hot laboratories and fuel fabrication plants produce solid wastes containing residual amounts of plutonium and uranium in nitrate and oxide form at concentrations up to several tens of grams per m/sup 3/. Dismantling of nuclear facilities having handled these radioelements also generates large volumes of solid wastes highly contaminated with alpha emitters. It is desirable to process these alpha wastes to recover valuable fissile materials and/or permit surface storage. Solid waste treatment by low-temperature impact crushing and then leaching, after minimal sorting and classifying at the sites of production, meets the corresponding requirements for high volume reduction plus fissile material recovery or waste decontamination. Additional volume reduction of crushed wastes containing mainly combustible materials can be obtained by incineration. This is facilitated by the low fissile material content after low-temperature impact crushing and leaching. Sorted wastes can also be leached or incinerated directly after, in most cases, crushing by more conventional techniques

  17. Basal cell carcinoma is associated with high TNF-alpha release but nor with TNF-alpha polymorphism at position--308

    DEFF Research Database (Denmark)

    Skov, Lone; Allen, Michael H; Bang, Bo

    2003-01-01

    secretion of TNF-alpha has been identified in humans. We have therefore investigated the association of the --308 polymorphism with the risk of basal cell carcinoma (BCC) in humans. The frequency of TNF G and TNF A alleles among Caucasian patients with a previous BCC (n=191) and health adults (n-107) were...... compared. For the TNF--308 polymorphism there was significant association between the genotype or allele frequencies and having BCC. To determine whether patients with a previous BCC had an increased capacity to secrete TNF-alpha, mononuclear cells were stimulated with lipopolysaccharide. Mononuclear cells...... from patients with a previous BCC (n=15) demonstrated a significantly increased release of TNF-alpha upon stimulation with lipopolysaccharide (Pcells age-matched control subjects (n=16). Further studies of other polymorphisms of the TNF-alpha gene associated...

  18. Simultaneous improvement in production of microalgal biodiesel and high-value alpha-linolenic acid by a single regulator acetylcholine

    OpenAIRE

    Parsaeimehr, Ali; Sun, Zhilan; Dou, Xiao; Chen, Yi-Feng

    2015-01-01

    Background Photoautotrophic microalgae are a promising avenue for sustained biodiesel production, but are compromised by low yields of biomass and lipids at present. We are developing a chemical approach to improve microalgal accumulation of feedstock lipids as well as high-value alpha-linolenic acid which in turn might provide a driving force for biodiesel production. Results We demonstrate the effectiveness of the small bioactive molecule ?acetylcholine? on accumulation of biomass, total li...

  19. Glasgow conference

    Energy Technology Data Exchange (ETDEWEB)

    Fraser, Gordon

    1994-10-15

    The biennial 'Rochester' International Conferences on High Energy Physics which tick the rhythm of high energy physics progress reflect the dominance of the 'Standard Model' - the picture of electroweak and quark/gluon interactions in a simple framework of six weaklyinteracting particles (leptons) and six quarks. Despite its limited intellectual appeal, after a decade of intense probing the Standard Model still refuses to budge.

  20. Interferons and interferon (IFN)-inducible protein 10 during highly active anti-retroviral therapy (HAART)-possible immunosuppressive role of IFN-alpha in HIV infection

    DEFF Research Database (Denmark)

    Stylianou, E; Aukrust, P; Bendtzen, K

    2000-01-01

    -infected patients had raised levels of both IP-10 and IFN-alpha compared with healthy controls (n = 19), with particularly high levels in advanced disease. HAART induced a marked decrease in levels of both IFN-alpha, neopterin and IP-10, though not to normal concentrations. In contrast, IFN-gamma levels were low...

  1. Low level tumor necrosis factor-alpha protects cardiomyocytes against high level tumor necrosis factor-alpha: brief insight into a beneficial paradox.

    Science.gov (United States)

    Cacciapaglia, Fabio; Salvatorelli, Emanuela; Minotti, Giorgio; Afeltra, Antonella; Menna, Pierantonio

    2014-12-01

    Whether tumor necrosis factor-alpha (TNFα) caused beneficial or detrimental cardiovascular effects remains poorly defined. Anti-TNFα agents improved cardiac end points in chronic rheumatic diseases characterized by progressive deterioration of cardiac function. In contrast, anti-TNFα agents did not always improve but actually worsened cardiac function in non-rheumatic patients with heart failure (HF), in spite of that HF usually accompanies with high circulating levels of TNFα. To shed light on these mixed findings, we characterized the effects of TNFα in H9c2 cardiomyocytes. Cells were incubated for 24 h with increasing concentrations of TNFα, hydrogen peroxide, aminotriazole, or etoposide. Posttreatment cell viability was assessed by antimycin A-inhibitable reduction of 3-(4,dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, and the IC50 value of each test compound was defined. H9c2 cells were also preconditioned with a low non-toxic concentration of TNFα and then re-challenged with increasing concentrations of TNFα and other stressor agents. In re-challenge experiments, all of the IC50 values increased significantly, with the IC50 value of TNFα increasing approximately 16-fold. TNFα preconditioning increased cardiomyocytes shedding of the external portion of transmembrane type 1 and type 2 TNFα receptors [(soluble TNFα receptors (sTNFR)]. Levels of survival-oriented soluble TNFR2 (sTNFR2) always exceeded those of death-oriented sTNFR1. When exposed to TNFα at its IC50 value, preconditioned cardiomyocytes showed an increased release of sTNFR2 but not sTNFR1. These results denoted that preconditioning by "low TNFα" helped cardiomyocyte to withstand toxicity from "high TNFα" or other agents. These results also suggested that beneficial or detrimental effects of anti-TNFα agents might well depend on whether these agents spared or intercepted discrete amounts of TNFα that preconditioned cardiomyocytes and made them more resistant to high

  2. Study of the antioxidant effect of {alpha}-tocopherol on low-density lipoprotein peroxidation induced at low and high {gamma}-radiation dose rates

    Energy Technology Data Exchange (ETDEWEB)

    Khalil, Abdelouahed [Research Centre on Aging and Department of Medicine, University of Sherbrooke, Sherbrooke, QC, J1H 4C4 (Canada)]. E-mail: abdelouahed.khalil@usherbrooke.ca; Milochevitch, Christelle [Research Centre on Aging and Department of Medicine, University of Sherbrooke, Sherbrooke, QC, J1H 4C4 (Canada)

    2005-02-01

    It is well known that vitamin E ({alpha}-tocopherol, {alpha}-toc) is a very efficient lipid soluble antioxidant and several studies showed its beneficial action in the prevention and reduction of atherosclerosis. However, some in vitro studies suggest a prooxidant role of vitamin E, which could occur under given circumstances. This study was thus designed to investigate the antioxidant vs. prooxidant effect of vitamin E with regards to LDL peroxidation induced under different oxidative stress conditions. LDL was enriched with {alpha}-tocopherol and different {alpha}-toc/LDL ratios were studied (8.0{+-}2.5, 14.3{+-}3.0, 33.3{+-}3.7, 42.7{+-}3.5 and 48.2{+-}4.5 molecules of {alpha}-toc/LDL particle). Enriched and control LDL were oxidized by action of {sup {center_dot}}OH and O{sub 2}{sup {center_dot}}{sup -} free radicals produced by {gamma}-radiolysis at different dose rates. Susceptibility of LDL to oxidation was examined by the measure of conjugated diene and TBARS formation as well as LDL endogenous {alpha}-toc disappearance. Increasing LDL {alpha}-toc concentration reduced the LDL susceptibility to oxidation and their oxidizability. {alpha}-toc disappearance rates were comprised between 43 and 8.3x10{sup -10} M s{sup -1} and decreased with the radiation dose rate. Our results support an antioxidant role for {alpha}-tocopherol at high and low oxidative stress conditions.

  3. At the European Physical Society (EPS) 1979 International Conference on High Energy Physics

    CERN Multimedia

    CERN PhotoLab

    1979-01-01

    To mark CERN's 25th Anniversary this year conference was held in Geneva from 27 June to 4 July, at the International Conference Centre. Here is Abdus Salam addressing theorists (on the first raw from left, Viki Weisskopf, Leon Van Hove, Giuliano Preparata).

  4. Alpha slow-moving high-density-lipoprotein subfraction in serum of a patient with radiation enteritis and peritoneal carcinosis

    International Nuclear Information System (INIS)

    Peynet, J.; Legrand, A.; Messing, B.; Thuillier, F.; Rousselet, F.

    1989-01-01

    An alpha slow-moving high-density-lipoprotein (HDL) subfraction was seen in a patient presenting with radiation enteritis and peritoneal carcinosis, who was given long-term cyclic parenteral nutrition. This subfraction, observed in addition to normal HDL, was precipitated with low-density lipoproteins (LDL) and very-low-density lipoproteins (VLDL) by sodium phosphotungstate-magnesium chloride. The patient's serum lipoproteins were analyzed after fractionation by density gradient ultracentrifugation. The alpha slow-moving HDL floated in the ultracentrifugation subfractions with densities ranging from 1.028 to 1.084 kg/L, and their main apolipoproteins included apolipoprotein E in addition to apolipoprotein A-I. These HDL were larger than HDL2. The pathogenesis of this unusual HDL subfraction is hypothesized

  5. OPERATIONAL LIMITATIONS FOR DEMOLITION OF A HIGHLY ALPHA CONTAMINATED BUILDING MODLES VERSUS MEASURED AIR & SURFACE ACTIVITY CONCENTRATIONS

    Energy Technology Data Exchange (ETDEWEB)

    LLOYD, E.R.

    2006-11-02

    The demolition of a facility historically used for processing and handling transuranic materials is considered. Residual alpha emitting radionuclide contamination poses an exposure hazard if released to the local environment during the demolition. The process of planning for the demolition of this highly alpha contaminated building, 232-Z, included a predemolition modeling analysis of potential exposures. Estimated emission rates were used as input to an air dispersion model to estimate frequencies of occurrence of peak air and surface exposures. Postdemolition modeling was also conducted, based on the actual demolition schedule and conditions. The modeling results indicated that downwind deposition is the main operational limitation for demolition of a highly alpha-contaminated building. During the demolition of 232-Z, airborne radiation and surface contamination were monitored. The resultant non-detect monitoring results indicate a significant level of conservatism in the modeled results. This comparison supports the use of more realistic assumption in the estimating emission rates. The resultant reduction in modeled levels of potential exposures has significant implications in terms of the projected costs of demolition of such structures.

  6. Novel AroA from Pseudomonas putida Confers Tobacco Plant with High Tolerance to Glyphosate

    Science.gov (United States)

    Yan, Hai-Qin; Chang, Su-Hua; Tian, Zhe-Xian; Zhang, Le; Sun, Yi-Cheng; Li, Yan; Wang, Jing; Wang, Yi-Ping

    2011-01-01

    Glyphosate is a non-selective broad-spectrum herbicide that inhibits 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS, also designated as AroA), a key enzyme in the aromatic amino acid biosynthesis pathway in microorganisms and plants. Previously, we reported that a novel AroA (PpAroA1) from Pseudomonas putida had high tolerance to glyphosate, with little homology to class I or class II glyphosate-tolerant AroA. In this study, the coding sequence of PpAroA1 was optimized for tobacco. For maturation of the enzyme in chloroplast, a chloroplast transit peptide coding sequence was fused in frame with the optimized aroA gene (PparoA1optimized) at the 5′ end. The PparoA1optimized gene was introduced into the tobacco (Nicotiana tabacum L. cv. W38) genome via Agrobacterium-mediated transformation. The transformed explants were first screened in shoot induction medium containing kanamycin. Then glyphosate tolerance was assayed in putative transgenic plants and its T1 progeny. Our results show that the PpAroA1 from Pseudomonas putida can efficiently confer tobacco plants with high glyphosate tolerance. Transgenic tobacco overexpressing the PparoA1optimized gene exhibit high tolerance to glyphosate, which suggest that the novel PpAroA1 is a new and good candidate applied in transgenic crops with glyphosate tolerance in future. PMID:21611121

  7. Design of chimeric expression elements that confer high-level gene activity in chromoplasts.

    Science.gov (United States)

    Caroca, Rodrigo; Howell, Katharine A; Hasse, Claudia; Ruf, Stephanie; Bock, Ralph

    2013-02-01

    Non-green plastids, such as chromoplasts, generally have much lower activity of gene expression than chloroplasts in photosynthetically active tissues. Suppression of plastid genes in non-green tissues occurs through a complex interplay of transcriptional and translational control, with the contribution of regulation of transcript abundance versus translational activity being highly variable between genes. Here, we have investigated whether the low expression of the plastid genome in chromoplasts results from inherent limitations in gene expression capacity, or can be overcome by designing appropriate combinations of promoters and translation initiation signals in the 5' untranslated region (5'-UTR). We constructed chimeric expression elements that combine promoters and 5'-UTRs from plastid genes, which are suppressed during chloroplast-to-chromoplast conversion in Solanum lycopersicum (tomato) fruit ripening, either just at the translational level or just at the level of mRNA accumulation. These chimeric expression elements were introduced into the tomato plastid genome by stable chloroplast transformation. We report the identification of promoter-UTR combinations that confer high-level gene expression in chromoplasts of ripe tomato fruits, resulting in the accumulation of reporter protein GFP to up to 1% of total cellular protein. Our work demonstrates that non-green plastids are capable of expressing genes to high levels. Moreover, the chimeric cis-elements for chromoplasts developed here are widely applicable in basic and applied research using transplastomic methods. © 2012 The Authors The Plant Journal © 2012 Blackwell Publishing Ltd.

  8. High-speed high-sensitivity infrared spectroscopy using mid-infrared swept lasers (Conference Presentation)

    Science.gov (United States)

    Childs, David T. D.; Groom, Kristian M.; Hogg, Richard A.; Revin, Dmitry G.; Cockburn, John W.; Rehman, Ihtesham U.; Matcher, Stephen J.

    2016-03-01

    Infrared spectroscopy is a highly attractive read-out technology for compositional analysis of biomedical specimens because of its unique combination of high molecular sensitivity without the need for exogenous labels. Traditional techniques such as FTIR and Raman have suffered from comparatively low speed and sensitivity however recent innovations are challenging this situation. Direct mid-IR spectroscopy is being speeded up by innovations such as MEMS-based FTIR instruments with very high mirror speeds and supercontinuum sources producing very high sample irradiation levels. Here we explore another possible method - external cavity quantum cascade lasers (EC-QCL's) with high cavity tuning speeds (mid-IR swept lasers). Swept lasers have been heavily developed in the near-infrared where they are used for non-destructive low-coherence imaging (OCT). We adapt these concepts in two ways. Firstly by combining mid-IR quantum cascade gain chips with external cavity designs adapted from OCT we achieve spectral acquisition rates approaching 1 kHz and demonstrate potential to reach 100 kHz. Secondly we show that mid-IR swept lasers share a fundamental sensitivity advantage with near-IR OCT swept lasers. This makes them potentially able to achieve the same spectral SNR as an FTIR instrument in a time x N shorter (N being the number of spectral points) under otherwise matched conditions. This effect is demonstrated using measurements of a PDMS sample. The combination of potentially very high spectral acquisition rates, fundamental SNR advantage and the use of low-cost detector systems could make mid-IR swept lasers a powerful technology for high-throughput biomedical spectroscopy.

  9. Direct chemical synthesis of 1 alpha,25-dihydroxy[26,27-3H] vitamin D3 with high specific activity: its use in receptor studies

    International Nuclear Information System (INIS)

    Napoli, J.L.; Mellon, W.S.; Fivizzani, M.A.; Schnoes, H.K.; DeLuca, H.F.

    1980-01-01

    The first direct chemical synthesis of radiolabeled 1 alpha, 25-dihydroxyvitamin D3 is reported. Unlike all previous syntheses, the new approach does not rely on enzymatic 1 alpha-hydroxylation of radiolabeled precursors. Rather, isotope is introduced in the last synthetic step by reaction of [3H] -methylmagnesium bromide with methyl 1 alpha-hydroxy-26,27-dinorvitamin D3-25-carboxylate to give 1 alpha,25-dihydroxy-[26,27-3H] vitamin D3 with a specific activity of 160 Ci/mmol. Mass spectroscopy confirmed that the radiohormone consists of a single isomer with six tritium atoms bound to carbons 26 and 27. Synthetically produced 1 alpha,25-dihydroxy [26,27-3H] vitamin D3 is indistinguishable from 1 alpha,25-dihydroxy-[26,27-3H] vitamin D3 obtained from the enzymatic 1 alpha-hydroxylation of 25-hydroxy[26,27-3H] vitamin D3 (160 Ci/mmol) by high-pressure liquid chromatography analysis and in the competitive binding assay using chick intestinal cytosol as the receptor source. Equilibrium dissociation constant measurements with the high specific activity radiohormone indicate a Kd of 8.2 x 10(-11) M for the chick intestinal cytosol 1 alpha,25-dihydroxyvitamin D3 receptor--a value considerably lower than the constants in the range of (1-5) x 10(-9) M previously reported

  10. Simultaneous improvement in production of microalgal biodiesel and high-value alpha-linolenic acid by a single regulator acetylcholine.

    Science.gov (United States)

    Parsaeimehr, Ali; Sun, Zhilan; Dou, Xiao; Chen, Yi-Feng

    2015-01-01

    Photoautotrophic microalgae are a promising avenue for sustained biodiesel production, but are compromised by low yields of biomass and lipids at present. We are developing a chemical approach to improve microalgal accumulation of feedstock lipids as well as high-value alpha-linolenic acid which in turn might provide a driving force for biodiesel production. We demonstrate the effectiveness of the small bioactive molecule "acetylcholine" on accumulation of biomass, total lipids, and alpha-linolenic acid in Chlorella sorokiniana. The effectiveness exists in different species of Chlorella. Moreover, the precursor and analogs of acetylcholine display increased effectiveness at higher applied doses, with maximal increases by 126, 80, and 60% over controls for biomass, total lipids, and alpha-linolenic acid, respectively. Production of calculated biodiesel was also improved by the precursor and analogs of acetylcholine. The biodiesel quality affected by changes in microalgal fatty acid composition was addressed. The chemical approach described here could improve the lipid yield and biodiesel production of photoautotrophic microalgae if combined with current genetic approaches.

  11. High-pressure phase equilibrium data for systems with carbon dioxide, {alpha}-humulene and trans-caryophyllene

    Energy Technology Data Exchange (ETDEWEB)

    Michielin, Eliane M.Z.; Rosso, Sibele R [EQA/UFSC, Chemical and Food Engineering Department, Federal University of Santa Catarina, C.P. 476, CEP 88040-900, Florianopolis, SC (Brazil); Franceschi, Elton; Borges, Gustavo R; Corazza, Marcos L; Oliveira, J Vladimir [Department of Food Engineering, URI - Campus de Erechim, Av. Sete de Setembro, 1621, Erechim, RS, 99700-000 (Brazil); Ferreira, Sandra R.S. [EQA/UFSC, Chemical and Food Engineering Department, Federal University of Santa Catarina, C.P. 476, CEP 88040-900, Florianopolis, SC (Brazil)], E-mail: sandra@enq.ufsc.br

    2009-01-15

    The aim of this work is to report phase equilibrium data for the binary systems (CO{sub 2} + {alpha}-humulene) and (CO{sub 2} + trans-caryophyllene), and for the ternary system (CO{sub 2} + {alpha}-humulene + trans-caryophyllene). Results from literature show that {alpha}-humulene and trans-caryophyllene are the main compounds responsible for the anti-inflammatory and anti-allergic characteristics attributed to the medicinal plant Cordia verbenacea D.C., hence giving importance to the phase behaviour investigation performed in this work. Phase equilibrium experiments were performed in a high-pressure, variable-volume view cell over the temperature range of T = (303 to 343) K and pressures up to 20 MPa. (Liquid + liquid) and (vapour + liquid + liquid) equilibrium were observed at T = 303 K, while (vapour + liquid) phase transitions were verified to occur from T = (313 to 343) K, for all systems studied. Thermodynamic modelling was performed using the Peng-Robinson equation of state and the classical quadratic mixing rules, with a satisfactory agreement between experimental and calculated values.

  12. Berkeley Conference

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1986-10-15

    To a regular observer at annual international meetings, progress in particle physics from one year to the next sometimes might seem ponderously slow. But shift the timescale and the result is startling. Opening his summary of the 1986 International Conference on High Energy Physics, held in Berkeley, California, from 16-23 July, Steve Weinberg first recalled the 1966 Conference, also held in Berkeley. Then the preoccupations were current algebra, hadron resonances and the interpretation of scattering in terms of Regge poles, and the theory of weak interactions. Physics certainly has moved.

  13. Berkeley Conference

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    To a regular observer at annual international meetings, progress in particle physics from one year to the next sometimes might seem ponderously slow. But shift the timescale and the result is startling. Opening his summary of the 1986 International Conference on High Energy Physics, held in Berkeley, California, from 16-23 July, Steve Weinberg first recalled the 1966 Conference, also held in Berkeley. Then the preoccupations were current algebra, hadron resonances and the interpretation of scattering in terms of Regge poles, and the theory of weak interactions. Physics certainly has moved

  14. Lisbon Conference

    International Nuclear Information System (INIS)

    Anon.

    1981-01-01

    Although no major physics discoveries were announced, the European Physical Society's International Conference on High Energy Physics, held in Lisbon from 9-15 July, was significant in that it showed the emerging pattern of physics for the 1980s

  15. Effects of a high-pressure treatment on the wheat alpha-amylase inhibitor and its relationship to elimination of allergenicity

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, S [Food Science Center, Niigata University, Ikarashi, Niigata, 950-2181 (Japan); Takanohashi, K; Nishiumi, T [Graduate School of Science and Technology, Niigata University, Ikarashi, Niigata, 950-2181 (Japan); Hara, T [Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Ikarashi, Niigata, 950-2181 (Japan); Odani, S [Department of Living Science and Technology, Faculty of Education and Human Science, Ikarashi, Niigata, 950-2181 (Japan); Suzuki, A, E-mail: shuyama@agr.niigata-u.ac.j [Department of Health and Nutrition, Faculty of Medical Science for Health, Teikyo Heisei University, Ikebukuro, Tokyo, 170-0013 (Japan)

    2010-03-01

    In this study, the effects of high-pressure treatment on structure and allergeincity of alpha amylase inhibitor (a-AI) were investigated. The pressure-induced structural changes of {alpha}-AI were estimated by fluorescence spectra and by fourth derivative UV-spectroscopy for probed tyrosine residues and by circular dichroism (CD) spectroscopy. The changes in the tertiary structure detected by fluorescence spectra and by fourth derivative UV-spectroscopy under high pressure were indicated at over 300 MPa. Measurements of CD spectroscopy suggested that the effects of a high-pressure treatment on changes in the secondary structure of {alpha}-AI were little. From our results, pressure-induced changes of the {alpha}-AI structure were not apparent. On the other hands, the IgE-specific binding activities of pressurized {alpha}-AI to sera from allergic patients against wheat, which is estimated by observations of dot-blotting, were decreased by high-pressure treatment. It is known that the pressure-induced elimination of allergenicity is related to the tertiary structural changes of allergen molecules. This study are suspected that the epitopes of {alpha}-AI do not contain tyrosine residues, and thus the decrease of IgE-specific binding activities is probably caused by the tertiary structural changes of these parts of {alpha}-AI.

  16. Estrogen-Related Receptor Alpha Confers Methotrexate Resistance via Attenuation of Reactive Oxygen Species Production and P53 Mediated Apoptosis in Osteosarcoma Cells

    Directory of Open Access Journals (Sweden)

    Peng Chen

    2014-01-01

    Full Text Available Osteosarcoma (OS is a malignant tumor mainly occurring in children and adolescents. Methotrexate (MTX, a chemotherapy agent, is widely used in treating OS. However, treatment failures are common due to acquired chemoresistance, for which the underlying molecular mechanisms are still unclear. In this study, we report that overexpression of estrogen-related receptor alpha (ERRα, an orphan nuclear receptor, promoted cell survival and blocked MTX-induced cell death in U2OS cells. We showed that MTX induced ROS production in MTX-sensitive U2OS cells while ERRα effectively blocked the ROS production and ROS associated cell apoptosis. Our further studies demonstrated that ERRα suppressed ROS induction of tumor suppressor P53 and its target genes NOXA and XAF1 which are mediators of P53-dependent apoptosis. In conclusion, this study demonstrated that ERRα plays an important role in the development of MTX resistance through blocking MTX-induced ROS production and attenuating the activation of p53 mediated apoptosis signaling pathway, and points to ERRα as a novel target for improving osteosarcoma therapy.

  17. Alpha particle emission as a probe of the level density in highly excited A∼200 nuclei

    International Nuclear Information System (INIS)

    Fabris, D.; Fioretto, E.; Viesti, G.; Cinausero, M.; Gelli, N.; Hagel, K.; Lucarelli, F.; Natowitz, J.B.; Nebbia, G.; Prete, G.; Wada, R.

    1994-01-01

    The alpha particle emission from 90 to 140 MeV 19 F+ 181 Ta fusion-evaporation reactions has been studied. The comparisons of the experimental spectral shapes and multiplicities with statistical model predictions indicate a need to use an excitation energy dependent level-density parameter a=A/K in which K increases with excitation energy. This increase is more rapid than that in lower mass nuclei. The effect of this change in level density on the prescission multiplicities in fission is significant

  18. Highly Potent, Water Soluble Benzimidazole Antagonist for Activated (alpha)4(beta)1 Integrin

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, R D; Andrei, M; Lau, E Y; Lightstone, F C; Liu, R; Lam, K S; Kurth, M J

    2007-08-29

    The cell surface receptor {alpha}{sub 4}{beta}{sub 1} integrin, activated constitutively in lymphoma, can be targeted with the bisaryl urea peptidomimetic antagonist 1 (LLP2A). However, concerns on its preliminary pharmacokinetic (PK) profile provided an impetus to change the pharmacophore from a bisaryl urea to a 2-arylaminobenzimidazole moiety resulting in improved solubility while maintaining picomolar potency [5 (KLCA4); IC{sub 50} = 305 pM]. With exceptional solubility, this finding has potential for improving PK to help diagnose and treat lymphomas.

  19. Biaxial creep deformation of Zircaloy-4 in the high alpha phase temperature range

    International Nuclear Information System (INIS)

    Donaldson, A.T.; Horwood, R.A.; Healey, T.

    1983-01-01

    The ballooning response of Zircaloy-4 fuel tubes during a postulated loss-of-coolant accident may be calculated from a knowledge of the thermal environment of the rods and the creep deformation characteristics of the cladding. In support of such calculations biaxial creep studies have been performed on fuel tubes supplied by Westinghouse, Wolverine and Sandvik of temperatures in the alpha phase range. This paper presents the results of an investigation of their respective creep behaviour which has resulted in the formulation of equations for use in LOCA fuel ballooning codes. (author)

  20. Redesign of a Variable-Gain Output Feedback Longitudinal Controller Flown on the High-Alpha Research Vehicle (HARV)

    Science.gov (United States)

    Ostroff, Aaron J.

    1998-01-01

    This paper describes a redesigned longitudinal controller that flew on the High-Alpha Research Vehicle (HARV) during calendar years (CY) 1995 and 1996. Linear models are developed for both the modified controller and a baseline controller that was flown in CY 1994. The modified controller was developed with three gain sets for flight evaluation, and several linear analysis results are shown comparing the gain sets. A Neal-Smith flying qualities analysis shows that performance for the low- and medium-gain sets is near the level 1 boundary, depending upon the bandwidth assumed, whereas the high-gain set indicates a sensitivity problem. A newly developed high-alpha Bode envelope criterion indicates that the control system gains may be slightly high, even for the low-gain set. A large motion-base simulator in the United Kingdom was used to evaluate the various controllers. Desired performance, which appeared to be satisfactory for flight, was generally met with both the low- and medium-gain sets. Both the high-gain set and the baseline controller were very sensitive, and it was easy to generate pilot-induced oscillation (PIO) in some of the target-tracking maneuvers. Flight target-tracking results varied from level 1 to level 3 and from no sensitivity to PIO. These results were related to pilot technique and whether actuator rate saturation was encountered.

  1. Transgenic cotton expressing Cry10Aa toxin confers high resistance to the cotton boll weevil.

    Science.gov (United States)

    Ribeiro, Thuanne Pires; Arraes, Fabricio Barbosa Monteiro; Lourenço-Tessutti, Isabela Tristan; Silva, Marilia Santos; Lisei-de-Sá, Maria Eugênia; Lucena, Wagner Alexandre; Macedo, Leonardo Lima Pepino; Lima, Janaina Nascimento; Santos Amorim, Regina Maria; Artico, Sinara; Alves-Ferreira, Márcio; Mattar Silva, Maria Cristina; Grossi-de-Sa, Maria Fatima

    2017-08-01

    Genetically modified (GM) cotton plants that effectively control cotton boll weevil (CBW), which is the most destructive cotton insect pest in South America, are reported here for the first time. This work presents the successful development of a new GM cotton with high resistance to CBW conferred by Cry10Aa toxin, a protein encoded by entomopathogenic Bacillus thuringiensis (Bt) gene. The plant transformation vector harbouring cry10Aa gene driven by the cotton ubiquitination-related promoter uceA1.7 was introduced into a Brazilian cotton cultivar by biolistic transformation. Quantitative PCR (qPCR) assays revealed high transcription levels of cry10Aa in both T 0 GM cotton leaf and flower bud tissues. Southern blot and qPCR-based 2 -ΔΔCt analyses revealed that T 0 GM plants had either one or two transgene copies. Quantitative and qualitative analyses of Cry10Aa protein expression showed variable protein expression levels in both flower buds and leaves tissues of T 0 GM cotton plants, ranging from approximately 3.0 to 14.0 μg g -1 fresh tissue. CBW susceptibility bioassays, performed by feeding adults and larvae with T 0 GM cotton leaves and flower buds, respectively, demonstrated a significant entomotoxic effect and a high level of CBW mortality (up to 100%). Molecular analysis revealed that transgene stability and entomotoxic effect to CBW were maintained in T 1 generation as the Cry10Aa toxin expression levels remained high in both tissues, ranging from 4.05 to 19.57 μg g -1 fresh tissue, and the CBW mortality rate remained around 100%. In conclusion, these Cry10Aa GM cotton plants represent a great advance in the control of the devastating CBW insect pest and can substantially impact cotton agribusiness. © 2017 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  2. Advances in high pressure research in condensed matter: proceedings of the international conference on condensed matter under high pressures

    International Nuclear Information System (INIS)

    Sikka, S.K.; Gupta, Satish C.; Godwal, B.K.

    1997-01-01

    The use of pressure as a thermodynamic variable for studying condensed matter has become very important in recent years. Its main effect is to reduce the volume of a substance. Thus, in some sense, it mimics the phenomena taking place during the cohesion of solids like pressure ionization, modifications in electronic properties and phase changes etc. Some of the phase changes under pressure lead to synthesis of new materials. The recent discovery of high T c superconductivity in YBa 2 Cu 3 O 7 may be indirectly attributed to the pressure effect. In applied fields like simulation of reactor accident, design of inertial confinement fusion schemes and for understanding the rock mechanical effects of shock propagation in earth due to underground nuclear explosions, the pressure versus volume relations of condensed matter are a vital input. This volume containing the proceedings of the International Conference on Condensed Matter Under High Pressure covers various aspects of high pressure pertaining to equations of state, phase transitions, electronic, optical and transport properties of solids, atomic and molecular studies, shock induced reactions, energetic materials, materials synthesis, mineral physics, geophysical and planetary sciences, biological applications and food processing and advances in experimental techniques and numerical simulations. Papers relevant to INIS are indexed separately

  3. Inhibition of transient receptor potential vanilloid-1 confers neuroprotection, reduces tumor necrosis factor-alpha, and increases IL-10 in a rat stroke model.

    Science.gov (United States)

    Hakimizadeh, Elham; Shamsizadeh, Ali; Roohbakhsh, Ali; Arababadi, Mohammad Kazemi; Hajizadeh, Mohammad R; Shariati, Mehdi; Rahmani, Mohammad R; Allahtavakoli, Mohammad

    2017-08-01

    Stroke is a major cause of mortality and long-term disability in adults. Transient receptor potential vanilloid-1 (TRPV1) plays a crucial role in neuroinflammation. In this study, the effects of TRPV1 agonist (capsaicin) and antagonist (AMG9810) on cerebral ischemia were investigated. Forty male Wistar rats were assigned to the following experimental groups: sham, vehicle) ischemic), AMG9810 (selective TRPV1 antagonist, 0.5 mg/kg; 3 h after stroke), and capsaicin (1 mg/kg; 3 h after stroke). Stroke was induced by permanent middle cerebral artery occlusion and neurological deficits were evaluated 1, 3, and 7 days after stroke. Then, infarct volume, brain edema, body temperature, mRNA expression of TRPV1, and serum concentrations of tumor necrosis factor-alpha (TNF-α) and IL-10 were measured. Compared to the vehicle group, AMG9810 significantly decreased the infarct volume (P < 0.01). Latency for the removal of sticky labels from the forepaw and the hanging time were significantly decreased and increased, respectively, following administration of AMG9810 (P < 0.01 and P < 0.001 vs. vehicle) 3 and 7 days after stroke. Compared to the sham group, the mRNA expression of TRPV1 was significantly increased in vehicle group (P < 0.01). Administration of AMG9810 significantly increased the anti-inflammatory cytokine IL-10 and decreased the inflammatory cytokine TNF-α (P < 0.05). Moreover, our results indicate that AMG9810 might a promising candidate for the hypothermic treatment of stroke. The findings also suggest a key role for AMG9810 in reducing inflammation after stroke and imply that TRPV1 could be a potential target for the treatment of ischemic stroke. © 2017 Société Française de Pharmacologie et de Thérapeutique.

  4. Expression of intracellular interferon-alpha confers antiviral properties in transfected bovine fetal fibroblasts and does not affect the full development of SCNT embryos.

    Directory of Open Access Journals (Sweden)

    Dawei Yu

    Full Text Available Foot-and-mouth disease, one of the most significant diseases of dairy herds, has substantial effects on farm economics, and currently, disease control measures are limited. In this study, we constructed a vector with a human interferon-α (hIFN-α (without secretory signal sequence gene cassette containing the immediate early promoter of human cytomegalovirus. Stably transfected bovine fetal fibroblasts were obtained by G418 selection, and hIFN-α transgenic embryos were produced by somatic cell nuclear transfer (SCNT. Forty-six transgenic embryos were transplanted into surrogate cows, and five cows (10.9% became pregnant. Two male cloned calves were born. Expression of hIFN-α was detected in transfected bovine fetal fibroblasts, transgenic SCNT embryos, and different tissues from a transgenic SCNT calf at two days old. In transfected bovine fetal fibroblasts, expression of intracellular IFN-α induced resistance to vesicular stomatitis virus infection, increased apoptosis, and induced the expression of double-stranded RNA-activated protein kinase gene (PKR and the 2'-5'-oligoadenylate synthetase gene (2'-5' OAS, which are IFN-inducible genes with antiviral activity. Analysis by qRT-PCR showed that the mRNA expression levels of PKR, 2'-5' OAS, and P53 were significantly increased in wild-type bovine fetal fibroblasts stimulated with extracellular recombinant human IFN-α-2b, showing that intracellular IFN-α induces biological functions similar to extracellular IFN-α. In conclusion, expression of intracellular hIFN-α conferred antiviral properties in transfected bovine fetal fibroblasts and did not significantly affect the full development of SCNT embryos. Thus, IFN-α transgenic technology may provide a revolutionary way to achieve elite breeding of livestock.

  5. High Level Radioactive Waste Management: Proceedings of the second annual international conference

    International Nuclear Information System (INIS)

    1991-01-01

    The final disposal of high level radioactive waste (HLW) has been one of the most arduous problems facing the nuclear industry. This issue has many facets, which are addressed in these proceedings. The papers herein contain the most current information regarding the conditioning and disposal of HLW. Most of the needs are technical in nature, such as the best form of the waste, the integrity of storage containers, design and construction of a repository, and characterization of the geology of a repository to provide assurance that radioactive and other hazardous materials will not reach the surrounding environment. Many of the papers discuss non-US programs. Continued international cooperation and technology exchange is essential. There are other concerns that must be addressed before the final emplacement of HLW. Some of the other issues addressed in these proceedings are conformance to regulations, transportation, socioeconomics, and public education. Any impediments in these areas must be resolved along with the scientific issues before final waste disposal. This conference provides a forum for information exchange. The papers in these proceedings will provide the basis for future planning and decisions. Continued cooperation of the technical community will ultimately result in the safe disposal of HLW. Individual abstracts are indexed separately for the data base

  6. Correlation of high-temperature stability of alpha-chymotrypsin with 'salting-in' properties of solution.

    Science.gov (United States)

    Levitsky VYu; Panova, A A; Mozhaev, V V

    1994-01-15

    A correlation between the stability of alpha-chymotrypsin against irreversible thermal inactivation at high temperatures (long-term stability) and the coefficient of Setchenov equation as a measure of salting-in/out efficiency of solutes in the Hofmeister series has been found. An increase in the concentration of salting-in solutes (KSCN, urea, guanidinium chloride, formamide) leads to a many-fold decrease of the inactivation rate of the enzyme. In contrast, addition of salting-out solutes has a small effect on the long-term stability of alpha-chymotrypsin at high temperatures. The effects of solutes are additive with respect to their salting-in/out capacities; the stabilizing action of the solutes is determined by the calculated Setchenov coefficient of solution. The correlation is explained by a solute-driven shift of the conformational equilibrium between the 'low-temperature' native and the 'high-temperature' denatured forms of the enzyme within the range of the kinetic scheme put forward in the preceding paper in this journal: irreversible inactivation of the high-temperature form proceeds much more slowly compared with the low-temperature form.

  7. Siting, design and construction of a deep geological repository for the disposal of high level and alpha bearing wastes

    International Nuclear Information System (INIS)

    1990-06-01

    The main objective of this document is to summarize the basic principles and approaches to siting, design and construction of a deep geological repository for disposal of high level and alpha bearing radioactive wastes, as commonly agreed upon by Member States. This report is addressed to decision makers and technical managers as well as to specialists planning for siting, design and construction of geological repositories for disposal of high level and alpha bearing wastes. This document is intended to provide Member States of the IAEA with a summary outline for the responsible implementing organizations to use for siting, designing and constructing confinement systems for high level and alpha bearing radioactive waste in accordance with the protection objectives set by national regulating authorities or derived from safety fundamentals and standards of the IAEA. The protection objectives will be achieved by the isolation of the radionuclides from the environment by a repository system, which consists of a series of man made and natural safety barriers. Engineered barriers are used to enhance natural geological containment in a variety of ways. They must complement the natural barriers to provide adequate safety and necessary redundancy to the barrier system to ensure that safety standards are met. Because of the long timescales involved and the important role of the natural barrier formed by the host rock, the site selection process is a key activity in the repository design and development programme. The choice of the site, the investigation of its geological setting, the exploration of the regional hydrogeological setting and the primary underground excavations are all considered to be part of the siting process. 16 refs

  8. Lyman Alpha Control

    CERN Document Server

    Nielsen, Daniel Stefaniak

    2015-01-01

    This document gives an overview of how to operate the Lyman Alpha Control application written in LabVIEW along with things to watch out for. Overview of the LabVIEW code itself as well as the physical wiring of and connections from/to the NI PCI-6229 DAQ box is also included. The Lyman Alpha Control application is the interface between the ALPHA sequencer and the HighFinesse Wavelength Meter as well as the Lyman Alpha laser setup. The application measures the wavelength of the output light from the Lyman Alpha cavity through the Wavelength Meter. The application can use the Wavelength Meter’s PID capabilities to stabilize the Lyman Alpha laser output as well as switch between up to three frequencies.

  9. EDITORIAL: Special issue featuring articles arising from the 11th High-Tech Plasma Processes Conference Special issue featuring articles arising from the 11th High-Tech Plasma Processes Conference

    Science.gov (United States)

    Bruggeman, Peter; Degrez, Gérard; Delplancke, Marie-Paule; Gleizes, Alain

    2011-05-01

    The 11th High-Tech Plasma Processes Conference (HTPP) was held in Brussels, Belgium, 27 June-2 July, 2010. HTPP started as a thermal plasma conference and gradually expanded to include low-temperature plasmas. The conference was founded by Jacques Amouroux and Pierre Fauchais, and aims to bring together different scientific communities to facilitate contacts between science, technology and industry, providing a platform for the exploration of elementary processes and applications in and by plasmas. The first HTPP was held in Odeillo, France, in 1990. Since then it has been held every other year in different European cities: Paris, Aachen, Athens, Strasbourg, Saint-Petersburg, Patras and Brussels. The 11th HTPP conference was attended by 125 participants from 19 countries. The program involved 14 invited talks, 34 contributed talks, 72 posters and a software demonstration and hands-on session for plasma modelling. The 12th HTPP conference will be held 24-28 June 2012, in Bologna, Italy. A larger part of the contributions to the 11th HTPP has been published in the Journal of Physics: Conference Series (JPCS) volume 275, 2011. All invited speakers and other contributors, as selected by the Steering, Scientific and Organizing Committee, were invited to submit a paper based on their contributions for this special issue which is peer reviewed by the journal. Both this special issue and the JPCS volume aim to bring the 11th HTPP to a wider audience. The publications are a nice example of the broad topic range of the conference. The JPCS volume contains papers covering fundamental aspects on radiative processes of thermal plasmas, modelling of thermal arcs and non-thermal RF plasma jets, plasma diagnostics including flow and heat flux measurements of thermal plasmas, radical density measurements and laser-induced breakdown spectroscopy. The applications-oriented contributions of the JPCS volume include plasma spraying, synthesis of (nano-sized) materials, surface

  10. Glasgow conference

    International Nuclear Information System (INIS)

    Fraser, Gordon

    1994-01-01

    The biennial 'Rochester' International Conferences on High Energy Physics which tick the rhythm of high energy physics progress reflect the dominance of the 'Standard Model' - the picture of electroweak and quark/gluon interactions in a simple framework of six weaklyinteracting particles (leptons) and six quarks. Despite its limited intellectual appeal, after a decade of intense probing the Standard Model still refuses to budge

  11. Development of thin foil Faraday collector as a lost alpha particle diagnostic for high yield D-T tokamak fusion plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Van Belle, P; Jarvis, O N; Sadler, G J [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Cecil, F E [Colorado School of Mines, Golden, CO (United States)

    1994-07-01

    Alpha particle confinement is necessary for ignition of a D-T tokamak fusion plasma and for first wall protection. Due to high radiation backgrounds and temperatures, scintillators and semiconductor detectors may not be used to study alpha particles which are lost to the first wall during the D-T programs on JET and ITER. An alternative method of charged particle spectrometry capable of operation in these harsh environments, is proposed: it consists of thin foils of electrically isolated conductors with the flux of alpha particles determined by the positive current flowing from the foils. 2 refs., 3 figs.

  12. Evaluation of Serum Levels of Pregnancy Associated Plasma Protein-A, Tumor Necrosis Factor-alpha and Highly Sensitive C-Reactive Protein in Diabetic Children

    International Nuclear Information System (INIS)

    Abdel-Messeih, PH.L.; El-safie, A.I.; Said, A.I.

    2011-01-01

    Recent evidence favours the primary role of cellular auto immunity and its humoral mediators in the pathogenesis and follow up of children with type 1 diabetes mellitus (type 1 DM). The present study is carried out to investigate serum levels of pregnancy associated plasma protein-A (PAPP-A), tumor necrosis factor-alpha (TNF-alpha ) and highly sensitive C-reactive protein (hs-CRP) in children with type 1 DM. Potential role of body mass index (BMI) was evaluated. Circulating levels of TNF-alpha, PAPP-A and hs-CRP are significantly increased in children with type 1 DM as compared with healthy subjects suggesting activation of inflammatory immune response system. A significant negative correlation was obtained between TNF-alpha and BMI in diabetic patients. This is highly suggestive of the availability of these non invasive indices to help further examining type 1 DM pathophysiology and monitoring pharmacological interventions to interfere with disease development and progression.

  13. High-temperature performance of gallium-nitride-based pin alpha-particle detectors grown on sapphire substrates

    Science.gov (United States)

    Zhu, Zhifu; Zhang, Heqiu; Liang, Hongwei; Tang, Bin; Peng, Xincun; Liu, Jianxun; Yang, Chao; Xia, Xiaochuan; Tao, Pengcheng; Shen, Rensheng; Zou, Jijun; Du, Guotong

    2018-06-01

    The temperature-dependent radiation-detection performance of an alpha-particle detector that was based on a gallium-nitride (GaN)-based pin structure was studied from 290 K to 450 K. Current-voltage-temperature measurements (I-V-T) of the reverse bias show the exponential dependence of leakage currents on the voltage and temperature. The current transport mechanism of the GaN-based pin diode from the reverse bias I-V fitting was analyzed. The temperature-dependent pulse-height spectra of the detectors were studied using an 241 Am alpha-particle source at a reverse bias of 10 V, and the peak positions shifted from 534 keV at 290 K to 490 keV at 450 K. The variation of full width at half maximum (FWHM) from 282 keV at 290 K to 292 keV at 450 K is almost negligible. The GaN-based pin detectors are highly promising for high-temperature environments up to 450 K.

  14. Consistent patterns of high alpha and low beta diversity in tropical parasitic and free-living protists.

    Science.gov (United States)

    Lentendu, Guillaume; Mahé, Frédéric; Bass, David; Rueckert, Sonja; Stoeck, Thorsten; Dunthorn, Micah

    2018-05-30

    Tropical animals and plants are known to have high alpha diversity within forests, but low beta diversity between forests. By contrast, it is unknown whether microbes inhabiting the same ecosystems exhibit similar biogeographic patterns. To evaluate the biogeographies of tropical protists, we used metabarcoding data of species sampled in the soils of three lowland Neotropical rainforests. Taxa-area and distance-decay relationships for three of the dominant protist taxa and their subtaxa were estimated at both the OTU and phylogenetic levels, with presence-absence and abundance-based measures. These estimates were compared to null models. High local alpha and low regional beta diversity patterns were consistently found for both the parasitic Apicomplexa and the largely free-living Cercozoa and Ciliophora. Similar to animals and plants, the protists showed spatial structures between forests at the OTU and phylogenetic levels, and only at the phylogenetic level within forests. These results suggest that the biogeographies of macro- and micro-organismal eukaryotes in lowland Neotropical rainforests are partially structured by the same general processes. However, and unlike the animals and plants, the protist OTUs did not exhibit spatial structures within forests, which hinders our ability to estimate the local and regional diversity of protists in tropical forests. © 2018 John Wiley & Sons Ltd.

  15. Site selection factors for repositories of solid high-level and alpha-bearing wastes in geological formations

    International Nuclear Information System (INIS)

    1977-01-01

    The purpose of this report is to provide guidelines for the selection and evaluation of suitable areas and sites for the disposal of solid high-level and alpha-bearing wastes into geological formations. This report is also intended to provide summary information on many types of geological formations underlying the land masses that might be considered as well as guidance on the geological and hydrological factors that should be investigated to demonstrate the suitability of the formations. In addition, other factors that should be considered in selecting a site for a radioactive waste repository are discussed briefly. The information, as presented, was developed to the extent of current technology for application to the evaluation of deep (greater than about 300 metres below ground level) geological formations in the selection of suitable areas for the disposal of solid or solidified high-level and alpha-bearing wastes. The extreme complexity of many geological environments and of the rock features that govern the presence and circulation of groundwater does not make it feasible to derive strict criteria for the selection of a site for a radioactive waste repository in a geological formation. Each potential repository location must be evaluated according to its own unique geological and hydrological setting. Therefore, only general guidance is offered, and this is done through discussion of the many factors that need to be considered in order to obtain the necessary assurances that the radionuclides will be confined in the geological repository over the required period of time

  16. Site selection factors for repositories of solid high-level and alpha-bearing wastes in geological formations

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    The purpose of this report is to provide guidelines for the selection and evaluation of suitable areas and sites for the disposal of solid high-level and alpha-bearing wastes into geological formations. This report is also intended to provide summary information on many types of geological formations underlying the land masses that might be considered as well as guidance on the geological and hydrological factors that should be investigated to demonstrate the suitability of the formations. In addition, other factors that should be considered in selecting a site for a radioactive waste repository are discussed briefly. The information, as presented, was developed to the extent of current technology for application to the evaluation of deep (greater than about 300 meters below ground level) geological formations in the selection of suitable areas for the disposal of solid or solidified high-level and alpha-bearing wastes. The extreme complexity of many geological environments and of the rock features that govern the presence and circulation of groundwater does not make it feasible to derive strict criteria for the selection of a site for a radioactive waste repository in a geological formation. Each potential repository location must be evaluated according to its own unique geological and hydrological setting. Therefore, only general guidance is offered, and this is done through discussion of the many factors that need to be considered in order to obtain the necessary assurances that the radionuclides will be confined in the geological repository over the required period of time.

  17. Alpha-PVP as an active component of herbal highs in Poland between 2013 and 2015.

    Science.gov (United States)

    Byrska, Bogumiła; Stanaszek, Roman; Zuba, Dariusz

    2017-08-01

    Alpha-PVP (alpha-pyrrolidinovalerophenone, α-PVP) is a synthetic derivative of cathinone. It has been one of the most frequently detected new psychoactive substances (NPS) available on the drug market in recent years in Poland. The usual routes of administration of the drug include oral, insufflation, and injection. Unexpectedly, we dealt with a great number of herbal samples that turned out to contain α-PVP. A total number of 352 herbal samples from 19 cases in which we detected synthetic cathinones, were investigated in the Institute of Forensic Research (IFR) from 2013 to 2015. The seized products that were received by our laboratory were first screened by gas chromatography coupled to mass spectrometry (GC-MS). Quantification of α-PVP and other cathinones was performed by ultra-performance liquid chromatography with photodiode array detection (UPLC-PDA). Of the samples, 84% contained only α-PVP. Other groups of products were those containing only α-PVT, α-PVP and α-PVT, α-PVP and synthetic cannabinoid A-834, 735, and α-PVP and cannabis. In one herbal sample, α-PVP was detected along with caffeine and tadalafil. The herbal products present on the market containing only α-PVP usually had a mass of 0.3 to 0.6 g, and concentration range in this group of samples was 3.0-44.0% (content: 13.0-222.0 mg per package). The amount of α-PVP in samples below 0.30 g was in a range 9-18 mg whiles in samples above 0.60 g it was in the range 30-716 mg. There were also products containing a mixture of α-PVP and α-PVT. In those samples, α-PVP concentrations were: 3.0-6.0% (amount: 15.0-34.0 mg). Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  18. A prospective randomized study of Chop versus Chop plus alpha-2B interferon in patients with intermediate and high grade non-Hodgkin's lymphoma: the International Oncology Study Group NHL1 Study .

    Science.gov (United States)

    Giles, F J; Shan, J; Advani, S H; Akan, H; Aydogdu, I; Aziz, Z; Azim, H A; Bapsy, P P; Buyukkececi, F; Chaimongkol, B; Chen, P M; Cheong, S K; Ferhanoglu, B; Hamza, R; Khalid, H M; Intragumtornchai, T; Kim, S W; Kim, S Y; Koc, H; Kumar, L; Kumar, R; Lei, K I; Lekhakula, A; Muthalib, A; Patel, M; Poovalingam, V P; Prayoonwiwat, W; Rana, F; Reksodiputro, A H; Ruff, P; Sagar, T G; Schwarer, A P; Song, H S; Suh, C W; Suharti, C; Supindiman, I; Tee, G Y; Thamprasit, T; Villalon, A H; Wickham, N R; Wong, J E; Yalcin, A; Jootar, S

    2000-12-01

    The addition of a brief alpha interferon regimen to each CHOP induction cycle, plus one year of alpha interferon thrice weekly maintenance therapy, has no early effect on response rates or survival in patients with Intermediate or High grade cell NHL. The CHOP (Cyclophosphamide, Adriamycin. Vincristine, Prednisone) regimen is the most widely used first-line therapy for patients with Intermediate or High Grade (IG/HG) non-Hodgkin's lymphoma (NHL). Alpha 2b interferon (INF) enhances response rates and improves survival in low-grade NHL. The International Oncology Study Group (IOSG) conducted a prospective randomized study comparing CHOP alone or combined with INF in patients with IG/HG-NHL. The primary study aim was to compare the objective response rates in these patient cohorts. Patients with a confirmed diagnosis of measurable NHL of International Working Formulation (IWF) groups D to H histology were randomized to receive CHOP alone or CHOP with 5Mu INF s.c. for 5 days on days 22 to 26 of each 28 day cycle with INF 5 million units (Mu) given three times per week subcutaneously for 52 weeks in those patients who responded to CHOP plus INF. The overall response rates were equivalent in both groups: CHOP alone (214 patients) 81% (complete 55%, partial 26%); CHOP plus INF (221 patients) 80% (complete 54%, partial 26%). At 36 months, the actuarial survival rate was equivalent in both groups. There is no apparent early advantage in terms of response or survival conferred by adding the study INF regimen to CHOP therapy for patients with IG/HG-NHL.

  19. New Trends in high-energy physics (experiment, phenomenology, theory). Proceedings of the International School-Conference

    International Nuclear Information System (INIS)

    Bogolyubov, P.N.; Jenkovszky, L.L.

    2000-01-01

    The subject of 'New Trends in High-Energy Physics' conference has been gradually extended now including: elastic and diffractive scattering of hadrons and nuclei, deep inelastic scattering and multiparticle dynamics, collective properties of the strongly interacting matter, heavy flavours and hadron spectroscopy, duality, strings an confinement, the standard model (and beyond), advances in quantum field theory, as well as new physics at future colliders

  20. Cerebral artery alpha-1 AR subtypes: high altitude long-term acclimatization responses.

    Directory of Open Access Journals (Sweden)

    Ravi Goyal

    Full Text Available In response to hypoxia and other stress, the sympathetic (adrenergic nervous system regulates arterial contractility and blood flow, partly through differential activities of the alpha1 (α1 - adrenergic receptor (AR subtypes (α1A-, α1B-, and α1D-AR. Thus, we tested the hypothesis that with acclimatization to long-term hypoxia (LTH, contractility of middle cerebral arteries (MCA is regulated by changes in expression and activation of the specific α1-AR subtypes. We conducted experiments in MCA from adult normoxic sheep maintained near sea level (300 m and those exposed to LTH (110 days at 3801 m. Following acclimatization to LTH, ovine MCA showed a 20% reduction (n = 5; P<0.05 in the maximum tension achieved by 10-5 M phenylephrine (PHE. LTH-acclimatized cerebral arteries also demonstrated a statistically significant (P<0.05 inhibition of PHE-induced contractility in the presence of specific α1-AR subtype antagonists. Importantly, compared to normoxic vessels, there was significantly greater (P<0.05 α1B-AR subtype mRNA and protein levels in LTH acclimatized MCA. Also, our results demonstrate that extracellular regulated kinase 1 and 2 (ERK1/2-mediated negative feedback regulation of PHE-induced contractility is modulated by α1B-AR subtype. Overall, in ovine MCA, LTH produces profound effects on α1-AR subtype expression and function.

  1. Positron annihilation measurements in high-energy alpha-irradiated n-type gallium arsenide

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Sandip; Mandal, Arunava; SenGupta, Asmita [Visva-Bharati, Department of Physics, Santiniketan, West Bengal (India); Roychowdhury, Anirban [UGC-DAE Consortium for Scientific Research, Kolkata Centre, Kolkata, West Bengal (India)

    2015-07-15

    Positron annihilation lifetime spectroscopy and Doppler broadening annihilation line-shape measurements have been carried out in 40-MeV alpha-irradiated n-type GaAs. After irradiation, the sample has been subjected to an isochronal annealing over temperature region of 25-800 C with an annealing time of 30 min at each set temperature. After each annealing, the positron measurements are taken at room temperature. Formation of radiation-induced defects and their recovery with annealing temperature are investigated. The lifetime spectra of the irradiated sample have been fitted with two lifetimes. The average positron lifetime τ{sub avg} = 244 ps at room temperature after irradiation indicates the presence of defects, and the value of τ{sub 2} (262 ps) at room temperature suggests that the probable defects are mono-vacancies. Two distinct annealing stages in τ{sub avg} at 400-600 C and at 650-800 C are observed. The variations in line-shape parameter (S) and defect-specific parameter (R) during annealing in the temperature region 25-800 C resemble the behaviour of τ{sub avg} indicating the migration of vacancies, formation of vacancy clusters and the disappearance of defects between 400 and 800 C. (orig.)

  2. A technique for high-sensitivity alpha autoradiography of bronchial epithelium tissue

    International Nuclear Information System (INIS)

    Henshaw, D.L.; Fews, A.P.; Webster, D.J.

    1979-01-01

    A technique for low-level alpha-particle autoradiography of bronchial epithelium utilising the plastic track detector, CR-39, is described. This plastic is new to the field of nuclear track detection and is very sensitive to α-particles. The recording properties of CR-39 for α-particles are described in detail and the technique for autoradiography discussed. This technique includes two methods of background reduction enabling activities as low as 2 α-particles cm -2 to be detected. The location of the point of emission of an α-particle from the tissue surface can be determined to an accuracy of a few μm. Determination of the lower limit to the energy of individual α-particles is possible from measurements of their range in the plastic. Examples are given of the determination of the microdistribution of α-particle active nuclei in bronchial tissue including the observation of two 'hot-spots' in an epithelium sample which are attributed to the presence of small particles of uranium with its daughter products. (author)

  3. High topographic resolution for the study of micro-distribution of alpha-emitters in bones

    International Nuclear Information System (INIS)

    Hanzlik, J.

    1977-10-01

    The project dealt with the method of using dielectric track detectors to determine the micro distribution of bone seekers, particularly radium-226. The bones studied were the mouse femur and vertebrae which were incorporated with radium-226. The preparatory work consisted of a.) preparation of dielectric foils suitable for optimal quantitative alpha autoradiography; b.) preparation of bone sections for such autoradiography; and c.) comparison of various dielectric materials. The autoradiographic method was applied to detect the radium deposition in small localities in bones and in particular, to determine the micro distribution with the aim of establishing a relationship between the incorporated activity and the dose. In evaluating such a relationship, it was concluded that it is essential to take into consideration the density distribution (using the macro method), the concentration gradient in the bands (using the semi micro method) and special track groups (using the micro method). Seven bands were observed characterized by transversal and longitudinal gradients. The transversal concentration gradients are functions of metabolism. The concentration gradients gave information about incorporative trend. Special track groupings indicate the existence of a variable course of repair process

  4. 78 FR 25255 - Atlantic Highly Migratory Species; Public Conference Call and Webinar Regarding Updates to the...

    Science.gov (United States)

    2013-04-30

    ... towards accomplishing the objectives listed therein. The presentation will be followed by a discussion... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC621 Atlantic... Administration (NOAA), Commerce. ACTION: Announcement of public conference call and webinar. SUMMARY: NMFS will...

  5. A detector module with highly efficient surface-alpha event rejection operated in CRESST-II Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, R. [Max-Planck-Institut fuer Physik, Munich (Germany); Technische Universitaet Muenchen, Physik-Department, Garching (Germany); Angloher, G.; Ferreiro, N.; Hauff, D.; Kiefer, M.; Petricca, F.; Proebst, F.; Reindl, F.; Seidel, W.; Stodolsky, L.; Tanzke, A.; Wuestrich, M. [Max-Planck-Institut fuer Physik, Munich (Germany); Bento, A. [Universidade de Coimbra, CIUC, Departamento de Fisica, Coimbra (Portugal); Bucci, C.; Canonica, L.; Gorla, P.; Schaeffner, K. [Laboratori Nazionali del Gran Sasso, INFN, Assergi (Italy); Erb, A. [Technische Universitaet Muenchen, Physik-Department, Garching (Germany); Walther-Meissner-Institut fuer Tieftemperaturforschung, Garching (Germany); Feilitzsch, F. von; Guetlein, A.; Lanfranchi, J.C.; Muenster, A.; Potzel, W.; Roth, S.; Schoenert, S.; Stanger, M.; Ulrich, A.; Wawoczny, S.; Willers, M.; Zoeller, A. [Technische Universitaet Muenchen, Physik-Department, Garching (Germany); Jochum, J.; Loebell, J.; Rottler, K.; Sailer, C.; Scholl, S.; Strandhagen, C.; Uffinger, M.; Usherov, I. [Eberhard-Karls-Universitaet Tuebingen, Physikalisches Institut, Tuebingen (Germany); Kluck, H. [Institut fuer Hochenergiephysik der Oesterreichischen Akademie der Wissenschaften, Wien (Austria); Vienna University of Technology, Atominstitut, Wien (Austria); Kraus, H. [University of Oxford, Department of Physics, Oxford (United Kingdom); Schieck, J. [Institut fuer Hochenergiephysik der Oesterreichischen Akademie der Wissenschaften, Wien (Austria); Sivers, M. von [Technische Universitaet Muenchen, Physik-Department, Garching (Germany); University of Bern, Albert Einstein Center for Fundamental Physics, Bern (Switzerland)

    2015-08-15

    The cryogenic dark matter experiment CRESSTII aims at the direct detection of WIMPs via elastic scattering off nuclei in scintillating CaWO{sub 4} crystals. We present a new, highly improved, detector design installed in the current run of CRESST-II Phase 2 with an efficient active rejection of surface-alpha backgrounds. Using CaWO{sub 4} sticks instead of metal clamps to hold the target crystal, a detector housing with fully-scintillating inner surface could be realized. The presented detector (TUM40) provides an excellent threshold of ∝0.60 keV and a resolution of σ ∼ 0.090 keV (at 2.60 keV).With significantly reduced background levels, TUM40 sets stringent limits on the spin-independent WIMP nucleon scattering cross section and probes a new region of parameter space for WIMP masses below 3GeV/c{sup 2}. In this paper, we discuss the novel detector design and the surface-alpha event rejection in detail. (orig.)

  6. (Alpha, gamma) irradiation effect on the alteration of high-level radioactive wastes matrices (UO2, hollandite, glass SON68)

    International Nuclear Information System (INIS)

    Suzuki, T.

    2007-06-01

    The aim of this work is to determine the effect of irradiation on the alteration of high level nuclear waste forms matrices. The matrices investigated are UO 2 to simulate the spent fuel, the hollandite for the specific conditioning of Cs, and the inactive glass SON68 representing the nuclear glass R7T7) The alpha irradiation experiments on UO 2 colloids in aqueous carbonate media have enabled to distinguish between the oxidation of UO 2 matrix as initial and dissolution as subsequent step. The simultaneous presence of carbonate and H 2 O 2 (product resulting from water radiolysis) increased the dissolution rate of UO 2 to its maximum value governed by the oxidation rate. ii) The study of hollandite alteration under gamma irradiation confirmed the good retention capacity for Cs and Ba. Gamma irradiation had brought only a little influence on releasing of Cs and Ba in solution. Electronic irradiation had conducted to the amorphization of the hollandite only for a dose 1000 times higher than the auto-induced dose of Ba over millions of years. iii) The experiences of glass irradiation under alpha beam and of helium implantation in the glass SON68 were analyzed by positon annihilation spectroscopy. No effect has been observed on the solid surface for an irradiation dose equal to 1000 years of storage. (author)

  7. The determination of $\\alpha_s$ by the ALPHA collaboration

    CERN Document Server

    Bruno, Mattia

    2016-01-01

    We review the ALPHA collaboration strategy for obtaining the QCD coupling at high scale. In the three-flavor effective theory it avoids the use of perturbation theory at $\\alpha > 0.2$ and at the same time has the physical scales small compared to the cutoff $1/a$ in all stages of the computation. The result $\\Lambda_\\overline{MS}^{(3)}=332(14)$~MeV is translated to $\\alpha_\\overline{MS}(m_Z)=0.1179(10)(2)$ by use of (high order) perturbative relations between the effective theory couplings at the charm and beauty quark "thresholds". The error of this perturbative step is discussed and estimated as $0.0002$.

  8. High-LET alpha-emitters: Radon, lung cancer and smoking

    International Nuclear Information System (INIS)

    Fabrikant, J.I.

    1988-11-01

    The National Academy of Sciences BEIR IV Report deals with the health effects in human populations exposed to internally-deposited alpha-emitting radionuclides and their decay products. Quantitative risk estimates for cancer induction are derived, mainly from analyses of epidemiological data. The Report addresses the health outcomes of exposure to radon and its daughters, primarily lung cancer risks of worker exposure to radon progeny in underground mines and in the general public in indoor domestic environments. An excess relative risk model of lung cancer mortality and exposure to radon progeny is developed; this models the excess risk per Working Level Month in terms of time intervals prior to an attained age, and is dependent on time-since-exposure and age at risk. Risk projections are presented and cover exposure situations of current public health concern. For example, lifetime exposure to 1 WLM y/sup /minus/1/ is estimated to increase the number of deaths due to lung cancer by a factor of about 1.5 over the current rate for both males and females in a population having the current prevalence of cigarette-smoking. Occupational exposure to 4 WLM y/sup /minus/1/ from ages 20 y to 40 y is projected to increase lung cancer deaths by a factor of 1.6 over the current rate of this age cohort in the general population. In all of these cases, most of the increased risk occurs to smokers for whom the risk is up to ten times greater than for non-smokers. 8 refs., 1 tab

  9. A non-perturbative exploration of the high energy regime in Nf=3 QCD. ALPHA Collaboration

    Science.gov (United States)

    Dalla Brida, Mattia; Fritzsch, Patrick; Korzec, Tomasz; Ramos, Alberto; Sint, Stefan; Sommer, Rainer

    2018-05-01

    Using continuum extrapolated lattice data we trace a family of running couplings in three-flavour QCD over a large range of scales from about 4 to 128 GeV. The scale is set by the finite space time volume so that recursive finite size techniques can be applied, and Schrödinger functional (SF) boundary conditions enable direct simulations in the chiral limit. Compared to earlier studies we have improved on both statistical and systematic errors. Using the SF coupling to implicitly define a reference scale 1/L_0≈ 4 GeV through \\bar{g}^2(L_0) =2.012, we quote L_0 Λ ^{N_f=3}_{{\\overline{MS}}} =0.0791(21). This error is dominated by statistics; in particular, the remnant perturbative uncertainty is negligible and very well controlled, by connecting to infinite renormalization scale from different scales 2^n/L_0 for n=0,1,\\ldots ,5. An intermediate step in this connection may involve any member of a one-parameter family of SF couplings. This provides an excellent opportunity for tests of perturbation theory some of which have been published in a letter (ALPHA collaboration, M. Dalla Brida et al. in Phys Rev Lett 117(18):182001, 2016). The results indicate that for our target precision of 3 per cent in L_0 Λ ^{N_f=3}_{{\\overline{MS}}}, a reliable estimate of the truncation error requires non-perturbative data for a sufficiently large range of values of α _s=\\bar{g}^2/(4π ). In the present work we reach this precision by studying scales that vary by a factor 2^5= 32, reaching down to α _s≈ 0.1. We here provide the details of our analysis and an extended discussion.

  10. Buffett's Alpha

    DEFF Research Database (Denmark)

    Frazzini, Andrea; Kabiller, David; Heje Pedersen, Lasse

    Berkshire Hathaway has realized a Sharpe ratio of 0.76, higher than any other stock or mutual fund with a history of more than 30 years, and Berkshire has a significant alpha to traditional risk factors. However, we find that the alpha becomes insignificant when controlling for exposures to Betting...

  11. Alpha Blockers

    Science.gov (United States)

    ... quickly, but their effects last only a few hours. Long-acting medications take longer to work, but their effects last longer. Which alpha blocker is best for you depends on your health and the condition being treated. Alpha blockers are ...

  12. Washington Conference

    International Nuclear Information System (INIS)

    Anon.

    1981-01-01

    The 1981 Particle Accelerator Conference was held in Washington from 11-13 March. It was the ninth in the series of meetings organized in the USA which differ from the 'International' meetings in their coverage of the full range of accelerator engineering and technology, including applications outside e field of high energy physics. The Conference took place under the cloud of further budget cuts for Fiscal Year 1982 in the USA which the Department of Energy has applied in line with the financial policy of the new administration. Coming on top of many years of budget trimming which have reduced the number of high energy physics Laboratories funded by the DOE to three (Brookhaven, Fermilab, Stanford - Cornell is funded by the National Science Foundation) and reduced the exploitation of these Laboratories to less than half of their potential, the new cuts did not exactly help to boost morale. Nevertheless, the huge amount of tailed work in accelerator physics and technology which was presented at the Conference showed how alive the field is

  13. Design of a mixer for the thrust-vectoring system on the high-alpha research vehicle

    Science.gov (United States)

    Pahle, Joseph W.; Bundick, W. Thomas; Yeager, Jessie C.; Beissner, Fred L., Jr.

    1996-01-01

    One of the advanced control concepts being investigated on the High-Alpha Research Vehicle (HARV) is multi-axis thrust vectoring using an experimental thrust-vectoring (TV) system consisting of three hydraulically actuated vanes per engine. A mixer is used to translate the pitch-, roll-, and yaw-TV commands into the appropriate TV-vane commands for distribution to the vane actuators. A computer-aided optimization process was developed to perform the inversion of the thrust-vectoring effectiveness data for use by the mixer in performing this command translation. Using this process a new mixer was designed for the HARV and evaluated in simulation and flight. An important element of the Mixer is the priority logic, which determines priority among the pitch-, roll-, and yaw-TV commands.

  14. High resolution alpha-autoradiography for measurement of 10B distribution in subcellular scale using CR-39 and AFM

    International Nuclear Information System (INIS)

    Amemiya, K.; Takahashi, H.; Yasuda, N.

    2000-01-01

    In order to measure 10 B distribution in tumor tissues for BNCT at subcellular scale, we have developed a new method for high resolution alpha-autoradiography using contact X-ray microscopy technique with CR-39 plastic track detectors. Sliced sections of boron-injected brain tumors in rats were mounted on CR-39 and irradiated with thermal neutrons at KUR. Then the samples were exposed to soft X-rays from a laser plasma source. After etching the CR-39 in NaOH solution for a short time (1-5 min.), transmission X-ray image of tumor cells appeared as relief on CR-39 surface, and could be observed with the atomic force microscopy (AFM). Very small etch pits of about 100 nm in diameter corresponding to particle tracks from 10 B(n, α) 7 Li reactions were also observed in the image simultaneously. This method provides an accurate distribution of 10 B inside the cell. (author)

  15. [Complex formation between alpha-chymotrypsin and block copolymers based on ethylene and propylene oxide, induced by high pressure].

    Science.gov (United States)

    Topchieva, I N; Sorokina, E M; Kurganov, B I; Zhulin, V M; Makarova, Z G

    1996-06-01

    A new method of formation of non-covalent adducts based on an amphiphilic diblock copolymer of ethylene and propylene oxides with molecular mass of 2 kDa and alpha-chymotrypsin (ChT) under high pressure, has been developed. The composition of the complexes corresponds to seven polymer molecules per one ChT molecule in the pressure range of 1.1 to 400 MPa. The complexes fully retain the catalytic activity. Kinetic constants (Km and kcat) for enzymatic hydrolysis of N-benzoyl-L-tyrosine ethyl ester catalyzed by the complexes are identical with the corresponding values for native ChT. Analysis of kinetics of thermal inactivation of the complexes revealed that the constant of the rate of the slow inactivation step is markedly lower than for ChT.

  16. A thin foil Faraday collector as a lost alpha detector for high yield d-t tokamak fusion plasmas

    International Nuclear Information System (INIS)

    Cecil, F. Ed

    2011-01-01

    This report summarizes the accomplishment of sixteen years of work toward the development of thin foil Faraday collectors as a lost energetic ion diagnostic for high temperature magnetic confinement fusion plasmas. Following initial, proof of principle accelerator based studies, devices have been tested on TFTR, NSTX, ALCATOR, DIII-D, and JET (KA-1 and KA-2). The reference numbers refer to the attached list of publications. The JET diagnostic KA-2 continues in operation and hopefully will provide valuable diagnostic information during a possible d-t campaign on JET in the coming years. A thin Faraday foil spectrometer, by virtue of its radiation hardness, may likewise provide a solution to the very challenging problem of lost alpha particle measurements on ITER and other future burning plasma machines.

  17. LaaA, a novel high-active alkalophilic alpha-amylase from deep-sea bacterium Luteimonas abyssi XH031(T).

    Science.gov (United States)

    Song, Qinghao; Wang, Yan; Yin, Chong; Zhang, Xiao-Hua

    2016-08-01

    Alpha-amylase is a kind of broadly used industrial enzymes, most of which have been exploited from terrestrial organism. Comparatively, alpha-amylase from marine environment was largely undeveloped. In this study, a novel alkalophilic alpha-amylase with high activity, Luteimonas abyssi alpha-amylase (LaaA), was cloned from deep-sea bacterium L. abyssi XH031(T) and expressed in Escherichia coli BL21. The gene has a length of 1428bp and encodes 475 amino acids with a 35-residue signal peptide. The specific activity of LaaA reached 8881U/mg at the optimum pH 9.0, which is obvious higher than other reported alpha-amylase. This enzyme can remain active at pH levels ranging from 6.0 to 11.0 and temperatures below 45°C, retaining high activity even at low temperatures (almost 38% residual activity at 10°C). In addition, 1mM Na(+), K(+), and Mn(2+) enhanced the activity of LaaA. To investigate the function of potential active sites, R227G, D229K, E256Q/H, H327V and D328V mutants were generated, and the results suggested that Arg227, Asp229, Glu256 and Asp328 were total conserved and essential for the activity of alpha-amylase LaaA. This study shows that the alpha-amylase LaaA is an alkali-tolerant and high-active amylase with strong potential for use in detergent industry. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Alpha1 and Alpha2 Integrins Mediate Invasive Activity of Mouse Mammary Carcinoma Cells through Regulation of Stromelysin-1 Expression

    Energy Technology Data Exchange (ETDEWEB)

    Lochter, Andre; Navre, Marc; Werb, Zena; Bissell, Mina J

    1998-06-29

    Tumor cell invasion relies on cell migration and extracellular matrix proteolysis. We investigated the contribution of different integrins to the invasive activity of mouse mammary carcinoma cells. Antibodies against integrin subunits {alpha}6 and {beta}1, but not against {alpha}1 and {alpha}2, inhibited cell locomotion on a reconstituted basement membrane in two-dimensional cell migration assays, whereas antibodies against {beta}1, but not against a6 or {alpha}2, interfered with cell adhesion to basement membrane constituents. Blocking antibodies against {alpha}1 integrins impaired only cell adhesion to type IV collagen. Antibodies against {alpha}1, {alpha}2, {alpha}6, and {beta}1, but not {alpha}5, integrin subunits reduced invasion of a reconstituted basement membrane. Integrins {alpha}1 and {alpha}2, which contributed only marginally to motility and adhesion, regulated proteinase production. Antibodies against {alpha}1 and {alpha}2, but not {alpha}6 and {beta}1, integrin subunits inhibited both transcription and protein expression of the matrix metalloproteinase stromelysin-1. Inhibition of tumor cell invasion by antibodies against {alpha}1 and {alpha}2 was reversed by addition of recombinant stromelysin-1. In contrast, stromelysin-1 could not rescue invasion inhibited by anti-{alpha}6 antibodies. Our data indicate that {alpha}1 and {alpha}2 integrins confer invasive behavior by regulating stromelysin-1 expression, whereas {alpha}6 integrins regulate cell motility. These results provide new insights into the specific functions of integrins during tumor cell invasion.

  19. Investigation of High Temperature Ductility Losses in Alpha-Beta Titanium Alloys

    Science.gov (United States)

    1988-04-01

    Strain Rate . ...... 89 4.1.3 Results of Initial Tests .9.... 94 4.2 CCT Diagram Development .. ......... .. 94 4.3 Lattice Incompatibility Measurements...123 5.1 Phase Stability and Transformations . . . 124 5.1.1 CCT Diagrams ........... 126 Aluminum Additions. ........ .147 Beta... CCT ) Diagram of Ti-6211..............101 1 4.6 High-Temperature X-Ray Diffraction Specimen Configurations..............106 4.7 High-Temperature X-Ray

  20. Regulation of hepatic branched-chain alpha-keto acid dehydrogenase complex in rats fed a high-fat diet

    Science.gov (United States)

    Objective: Branched-chain alpha-keto acid dehydrogenase complex (BCKDC) regulates branched-chain amino acid (BCAA) metabolism at the level of branched chain alpha-ketoacid (BCKA) catabolism. It has been demonstrated that the activity of hepatic BCKDC is markedly decreased in type 2 diabetic animal...

  1. International Cryocooler Conference

    CERN Document Server

    Cryocoolers 13

    2005-01-01

    This is the 13th volume in the conference series. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature super-capacitor applications.

  2. Beams `96. Proceedings of the 11th international conference on high power particle beams. Vol. II

    Energy Technology Data Exchange (ETDEWEB)

    Jungwirth, K.; Ullschmied, J. [eds.

    1997-12-31

    The scientific programme of the conference carved the physics and technology of intense beams of charged particles, from basic experimental and theoretical problems of beam generation, transport and interaction with various media, up to beam and pulsed power applications in science and in industry. The breakdown of the papers by main topical groups is as follows: radiation sources, Z-pinches, accelerate related topics, astrophysics, ICF, ION Beam Physics, ION DIODES, ION RINGS, Beam plasma systems, diagnostic and others. This volumes contains 160 contributions, out which 133 have been input to INIS.

  3. Beams '96. Proceedings of the 11th international conference on high power particle beams. Vol. II

    International Nuclear Information System (INIS)

    Jungwirth, K.; Ullschmied, J.

    1996-01-01

    The scientific programme of the conference carved the physics and technology of intense beams of charged particles, from basic experimental and theoretical problems of beam generation, transport and interaction with various media, up to beam and pulsed power applications in science and in industry. The breakdown of the papers by main topical groups is as follows: radiation sources, Z-pinches, accelerate related topics, astrophysics, ICF, ION Beam Physics, ION DIODES, ION RINGS, Beam plasma systems, diagnostic and others. This volumes contains 160 contributions, out which 133 have been input to INIS

  4. High performance thermal insulation systems (HiPTI). Vacuum insulated products (VIP). Proceedings of the international conference and workshop

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, M.; Bertschinger, H.

    2001-07-01

    These are the proceedings of the International Conference and Workshop held at EMPA Duebendorf, Switzerland, in January 2001. The papers presented at the conference's first day included contributions on the role of high-performance insulation in energy efficiency - providing an overview of available technologies and reviewing physical aspects of heat transfer and the development of thermal insulation as well as the state of the art of glazing technologies such as high-performance and vacuum glazing. Also, vacuum-insulated products (VIP) with fumed silica, applications of VIP systems in technical building systems, nanogels, VIP packaging materials and technologies, measurement of physical properties, VIP for advanced retrofit solutions for buildings and existing and future applications for advanced low energy building are discussed. Finally, research and development concerning VIP for buildings are reported on. The workshops held on the second day covered a preliminary study on high-performance thermal insulation materials with gastight porosity, flexible pipes with high performance thermal insulation, evaluation of modern insulation systems by simulation methods as well as the development of vacuum insulation panels with a stainless steel envelope.

  5. FOREWORD: The 4th CCM International Conference on Pressure Metrology from Ultra-High Vacuum to Very High Pressures (10-9 Pa to 109 Pa)

    Science.gov (United States)

    Legras, Jean-Claude; Jousten, Karl; Severn, Ian

    2005-12-01

    The fourth CCM (Consultative Committee for Mass and related quantities) International Conference on Pressure Metrology from Ultra-High Vacuum to Very High Pressures (10-9 Pa to 109 Pa) was held at the Institute of Physics in London from 19-21 April 2005. The event, which was organized by the Low, Medium and High Pressure working groups of the CCM, was attended by in excess of one hundred participants with representatives from five continents and every regional metrology organization. The purpose of this conference is to review all the work that is devoted to the highest quality of pressure measurement by primary standards as well as the dissemination of the pressure scale. A total of 52 papers were presented orally, and 26 as posters, in sessions that covered the following topics: Latest scientific advances in pressure and vacuum metrology Innovative transfer standards, advanced sensors and new instrument development Primary (top-level) measurement standards International and regional key comparisons New approaches to calibration It is interesting the note that since the third conference in 1999 the pressure range covered has increased by two orders of magnitude to 109 Pa, to take into account more exacting scientific and industrial demands for traceable vacuum measurement. A further feature of the conference was the increased range of instrumentation and techniques used in the realization and potential realization of pressure standards. Seton Bennett, Director of International Metrology at the National Physical Laboratory, opened the conference and Andrew Wallard, Director of the Bureau International des Poids et Mesures (BIPM), gave the keynote address which described the implementation of the mutual recognition arrangement and the resulting removal of metrological barriers to international trade. Many experts have contributed significant amounts of their time to organize the event and to review the submitted papers. Thanks are due to all of these people

  6. Treatment with interferon-alpha delays disease in swine infected with a highly virulent CSFV strain

    Science.gov (United States)

    Classical swine fever (CSF) is an economically significant, highly contagious swine disease. The etiological agent, CSF virus (CSFV), is an enveloped virus with a positive-sense, single-stranded RNA genome, classified as a member of the genus Pestivirus within the family Flaviviridae (Becher et al.,...

  7. The alpha channeling effect

    Science.gov (United States)

    Fisch, N. J.

    2015-12-01

    Alpha particles born through fusion reactions in a tokamak reactor tend to slow down on electrons, but that could take up to hundreds of milliseconds. Before that happens, the energy in these alpha particles can destabilize on collisionless timescales toroidal Alfven modes and other waves, in a way deleterious to energy confinement. However, it has been speculated that this energy might be instead be channeled into useful energy, so as to heat fuel ions or to drive current. Such a channeling needs to be catalyzed by waves Waves can produce diffusion in energy of the alpha particles in a way that is strictly coupled to diffusion in space. If these diffusion paths in energy-position space point from high energy in the center to low energy on the periphery, then alpha particles will be cooled while forced to the periphery. The energy from the alpha particles is absorbed by the wave. The amplified wave can then heat ions or drive current. This process or paradigm for extracting alpha particle energy collisionlessly has been called alpha channeling. While the effect is speculative, the upside potential for economical fusion is immense. The paradigm also operates more generally in other contexts of magnetically confined plasma.

  8. Alpha-particle effects on high-n instabilities in tokamaks

    International Nuclear Information System (INIS)

    Rewoldt, G.

    1988-06-01

    Hot α-particles and thermalized helium ash particles in tokamaks can have significant effects on high toroidal mode number instabilities such as the trapped-electron drift mode and the kinetically calculated magnetohydrodynamic ballooning mode. In particular, the effects can be stabilizing, destabilizing, or negligible, depending on the parameters involved. In high-temperature tokamaks capable of producing significant numbers of hot α-particles, the predominant interaction of the mode with the α-particles is through resonances of various sorts. In turn, the modes can cause significant anomalous transport of the α-particles and the helium ash. Here, results of comprehensive linear eigenfrequency-eigenfunction calculations are presented for relevant realistic cases to show these effects. 24 refs., 12 figs., 6 tabs

  9. Climate change in high definition : scenarios for impacts and adaptation research : conference proceedings

    International Nuclear Information System (INIS)

    2007-01-01

    This conference provided a forum to review information and tools to conduct climate change impact and adaptation research and assessments. The research community, policy advisors and resource managers reviewed the latest advancements in global and regional climate modeling, climate scenarios, downscaling tools and application of scenarios for decision-making. The new Climate Change Scenarios Network (CCSN) website was also launched at this meeting, which also provided training in Environment Canada's new statistical downscaling tool developed in collaboration with the Institut National de la Recherche Scientifique, Eau, Terre et Environnement (INRS-ETE). New features of the CCSN were presented along with examples of how information from the network can be applied in specific cases, including assessments of impacts in areas such as human health and water resources. A training session on downscaling with the newly developed Automated Statistical Downscaling (ASD) tool was also provided. The conference featured 19 presentations, of which 3 have been catalogued separately for inclusion in this database. refs., tabs., figs

  10. Proceedings of the international conference on nuclear structure at high angular momentum and the workshop on large gamma-ray detector arrays. Conference summaries

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-05-01

    The proceedings of the conference/workshop is being published in two volumes. Abstracts of all contributed papers are contained in volume 1. The final proceedings will be published as volume 2 under the same report number (AECL--10613), and will contain expanded versions of abstracts submitted by registered participants together with the invited and contributed talks.

  11. Proceedings of the international conference on nuclear structure at high angular momentum and the workshop on large gamma-ray detector arrays. Conference summaries

    International Nuclear Information System (INIS)

    1992-05-01

    The proceedings of the conference/workshop is being published in two volumes. Abstracts of all contributed papers are contained in volume 1. The final proceedings will be published as volume 2 under the same report number (AECL--10613), and will contain expanded versions of abstracts submitted by registered participants together with the invited and contributed talks

  12. In-situ observation of the alpha/beta cristobalite transition using high voltage electron microscopy

    International Nuclear Information System (INIS)

    Meike, A.; Glassley, W.

    1989-10-01

    A high temperature water vapor phase is expected to persist in the vicinity of high level radioactive waste packages for several hundreds of years. The authors have begun an investigation of the structural and chemical effects of water on cristobalite because of its abundance in the near field environment. A high voltage transmission electron microscope (HVEM) investigation of bulk synthesized α-cristobalite to be used in single phase dissolution and precipitation kinetics experiments revealed the presence β-cristobalite, quartz and amorphous silica, in addition to α-cristobalite. Consequently, this apparent metastable persistence of β-cristobalite and amorphous silica during the synthesis of α-cristobalite was investigated using a heating stage and an environmental cell installed in the HVEM that allowed the introduction of either dry CO 2 or a CO 2 + H 2 O vapor. Preliminary electron diffraction evidence suggests that the presence of water vapor affected the α-β transition temperature. Water vapor may also be responsible for the development of an amorphous silica phase at the transition that may persist over an interval of several tens of degrees. The amorphous phase was not documented during the dry heating experiments. 20 refs., 7 figs., 5 tabs

  13. In-situ observation of the alpha/beta cristobalite transition using high voltage electron microscopy

    International Nuclear Information System (INIS)

    Meike, A.; Glassley, W.E.

    1990-01-01

    A high temperature water vapor phase is expected to persist in the vicinity of high level radioactive waste packages for several hundreds of years. The authors have begun an investigation of the structural and chemical effects of water on cristobalite because of its abundance in the near field environment. A high voltage transmission electron microscope (HVEM) investigation of bulk synthesized α-cristobalite to be used in single phase dissolution and precipitation kinetics experiments revealed the presence β-cristobalite, quartz and amorphous silica, in addition to α-cristobalite. Consequently, this apparent metastable persistence of β-cristobalite and amorphous silica during the synthesis of α-cristobalite was investigated using a heating stage and an environmental cell installed in the HVEM that allowed the introduction of either dry CO 2 or a CO 2 + H 2 O vapor. Preliminary electron diffraction evidence suggests that the presence of water vapor affected the α-β transition temperature. Water vapor may also be responsible for the development of an amorphous silica phase at the transition that may persist over an interval of several tens of degrees. The amorphous phase was not documented during the dry heating experiments

  14. High-throughput hydrolysis of starch during permeation across {alpha}-amylase-immobilized porous hollow-fiber membranes

    Energy Technology Data Exchange (ETDEWEB)

    Miura, Suguru; Kubota, Noboru; Kawakita, Hidetaka; Saito, Kyoichi E-mail: marukyo@xtal.tf.chiba-u.ac.jp; Sugita, Kazuyuki; Watanabe, Kohei; Sugo, Takanobu

    2002-02-01

    Two kinds of supporting porous membranes, ethanolamine (EA) and phenol (Ph) fibers, for immobilization of {alpha}-amylase were prepared by radiation-induced graft polymerization of an epoxy-group-containing monomer, glycidyl methacrylate, onto a porous hollow-fiber membrane, and subsequent ring-opening with EA and Ph, respectively. An {alpha}-amylase solution was forced to permeate radially outward through the pores of the EA and Ph fibers. {alpha}-Amylase was captured at a density of 0.15 and 6.6 g/L of the membrane by the graft chain containing 2-hydroxyethylamino and phenyl groups, respectively. A permeation pressure of 0.10 MPa provided a space velocity of 780 and 1500 h{sup -1} for the {alpha}-amylase-immobilized EA and Ph fibers, respectively. Quantitative hydrolysis of starch during permeation of a 20 g/L starch solution in the buffer across the {alpha}-amylase-immobilized Ph fiber was attained up to a space velocity of about 2000 h{sup -1}; this was achieved because of negligible diffusional mass-transfer resistance of the starch to the {alpha}-amylase due to convective flow/ whereas an enzyme reaction-controlled system was observed for the {alpha}-amylase-immobilized EA fiber.

  15. Determination of alpha-Tocopherol (vitamin E) in irradiated garlic by high performance liquid chromatography (HPLC)

    International Nuclear Information System (INIS)

    Rios, Magda Dias Goncalves; Penteado, Marilene de Vuono Camargo

    2003-01-01

    The effects of 60 Co ionizing radiations in doses of 0, 75, 100, 150, 200 and 250Gy on garlic, upon the α-tocopherol concentration were studied. The α-tocopherol contents were established by high performance liquid chromatography (HPLC), after direct hexane extraction from the garlic samples. The α-tocopherol was determined through normal phase column, and mobile phase was composed by hexane: iso-propyl alcohol (99:01 v/v), with 2mL/min flow rate and fluorescence detector. It is statistically shown that an irradiation dose of up to 150 Gy does not affect the garlic α-tocopherol content. (author)

  16. The radiological evaluation of a prototype posting-in hatch under conditions of high alpha activity

    International Nuclear Information System (INIS)

    Smith, D.I.; Hollick, R.C.

    1987-07-01

    A prototype posting-in hatch, mounted vertically in the top panel of a highly active glovebox has been radiologically evaluated in the Fuels Laboratory, AEEW. This simple, air-lock type system of 100 mm diameter has pneumatically operated and interlocked lids and a low velocity, inward purge, supplied by the glovebox depression. The hatch proved extremely reliable and very easy to operate. More than 1200 simulated posting movements were carried out and a > 8 order of magnitude reduction in aerosol concentration was recorded from the active glovebox to the monitoring environment. (author)

  17. Alpha spectrum profiling of plutonium in leached simulated high-level radioactive waste-glass

    International Nuclear Information System (INIS)

    Diamond, H.; Friedman, A.M.

    1981-01-01

    Low-geometry X-ray spectra from /sup 239/Pu and /sup 237/Np, incorporated into simulated high-level radioactive waste-glass, were transformed into depth distributions for these elements. Changes in the depth profiles were observed for a series of static leachings in 75/degree/C water. Radiochemical assay of the leach solutions revealed that little neptunium or plutonium was leached, and that the amount leached was independent of leaching time. The depth profiles of the leached specimens showed that there was selective leaching of nonradioactive components of the glass, concentrating the remaining neptunium and plutonium in a broad zone near (but not at) the glass surface. Eventual redeposition of nonradioactive material onto the glass surface inhibited further leaching

  18. Prediction for the high-level alpha-active waste to be generated by nuclear power stations in the Member States of the European Communities

    International Nuclear Information System (INIS)

    Schmidt, E.

    1977-04-01

    Starting with a forecast for the nuclear power generating capacity to be installed in the Member States of the European Communities before the end of this century, a prediction is made of the annual production of high-level alpha-active waste from reprocessing plants and the corresponding accumulation up to the year 2000. The isotopic composition of the alpha-active waste from individual reactor types was calculated and an estimation of the influence of recycling plutonium through light water reactors on the produced quantity of higher actinides is made

  19. Discovering an Accessible Enzyme: Salivary [alpha]-Amylase--"Prima Digestio Fit in Ore"--A Didactic Approach for High School Students

    Science.gov (United States)

    Marini, Isabella

    2005-01-01

    Human salivary [alpha]-amylase is used in this experimental approach to introduce biology high school students to the concept of enzyme activity in a dynamic way. Through a series of five easy, rapid, and inexpensive laboratory experiments students learn what the activity of an enzyme consists of: first in a qualitative then in a semi-quantitative…

  20. Alpha-particle-induced soft errors in high speed bipolar RAM

    International Nuclear Information System (INIS)

    Mitsusada, Kazumichi; Kato, Yukio; Yamaguchi, Kunihiko; Inadachi, Masaaki

    1980-01-01

    As bipolar RAM (Random Access Memory) has been improved to a fast acting and highly integrated device, the problems negligible in the past have become the ones that can not be ignored. The problem of a-particles emitted from the radioactive substances in semiconductor package materials should be specifically noticed, which cause soft errors. The authors have produced experimentally the special 1 kbit bipolar RAM to investigate its soft errors. The package used was the standard 16 pin dual in-line type, with which the practical system mounting test and a-particle irradiation test have been performed. The results showed the occurrence of soft errors at the average rate of about 1 bit/700 device hour. It is concluded that the cause was due to the a-particles emitted from the package materials, and at the same time, it was found that the rate of soft error occurrence was able to be greatly reduced by shielding a-particles. The error rate significantly increased with the decrease of the stand-by current of memory cells and with the accumulated charge determined by time constant. The mechanism of soft error was also investigated, for which an approximate model to estimate the error rate by means of the effective noise charge due to a-particles and of the amount of reversible charges of memory cells is shown to compare it with the experimental results. (Wakatsuki, Y.)

  1. Papers presented at the eleventh topical conference on high-temperature plasma diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    This report contains the following eleven papers presented at the conference: Neutral Beam Diagnostics for Alcator C-Mod; A Study for the Installation of the TEXT HIBP on DIII-D; Time-domain Triple-probe Measurement of Edge Plasma Turbulence on TEXT-U; A Langmuir/Mach Probe Array for Edge Plasma Turbulence and Flow; Determination of Field Line Location and Safety Factor in TEXT-U; Hybrid ECE Imaging Array System for TEXT-U; First Results from the Phase Contrast Imaging System on TEXT-U; A Fast Tokamak Plasma Flux and Electron Density Reconstruction Technique; Time-series Analysis of Nonstationary Plasma Fluctuations Using Wavelet Transforms; Quantitative Modeling of 3-D Camera Views for Tokamak Divertors; and Variable-frequency Complex Demodulation Technique for Extracting Amplitude and Phase Information. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  2. Papers presented at the eleventh topical conference on high-temperature plasma diagnostics

    International Nuclear Information System (INIS)

    1996-01-01

    This report contains the following eleven papers presented at the conference: Neutral Beam Diagnostics for Alcator C-Mod; A Study for the Installation of the TEXT HIBP on DIII-D; Time-domain Triple-probe Measurement of Edge Plasma Turbulence on TEXT-U; A Langmuir/Mach Probe Array for Edge Plasma Turbulence and Flow; Determination of Field Line Location and Safety Factor in TEXT-U; Hybrid ECE Imaging Array System for TEXT-U; First Results from the Phase Contrast Imaging System on TEXT-U; A Fast Tokamak Plasma Flux and Electron Density Reconstruction Technique; Time-series Analysis of Nonstationary Plasma Fluctuations Using Wavelet Transforms; Quantitative Modeling of 3-D Camera Views for Tokamak Divertors; and Variable-frequency Complex Demodulation Technique for Extracting Amplitude and Phase Information. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database

  3. Population policies for 21st century. Population and sustainable development high on agenda at Bali conference.

    Science.gov (United States)

    1992-10-01

    At the August 1992 Population Conference for Asia and the Pacific held in Bali, a state minister from Indonesia remarked that changes in population growth must occur along with changes in quality of life and that more effective family planning (FP), family health, and welfare programs were needed. FP programs must be internally financed by each country. Conference goals were to assist governments in understanding the value of having multidisciplinary policies and programs, the need for research and evaluation in program implementation, and the role of population data for planning and policy. Senior officials from 36 countries and representatives from international bodies attended the week-long meetings. There was representation from outside the regional (Syria, Sweden, the Holy See, and the World Bank). A series of goals for the 21st century were agreed upon by participants in the Bali Declaration on Population and Sustainable Development. The message that there were no "quick fixes" was communicated and that women need to be involved in development beyond their role as wives as mothers. Dr. Sadik spoke about the importance of reducing maternal mortality and improving reproductive health. In Southeast Asia alone maternal deaths number about 250,000/year. The solution is family planning particularly for women older than 35 years and teenagers and social welfare programs for improving health care, fertility regulation, nutrition, and income. Dr. Sadik also focused on placing the elimination of poverty, improving women's conditions, and enabling reproductive choice as top priorities on country agendas. The issue of a large aging population in Southeast Asia necessitates future planning. The Japanese delegation pledged continued bilateral and multilateral cooperation in population control, with the hope that Japan may be useful as an example to other countries. There was participant commitment to the creation of policies on population and sustainable development.

  4. Role of quenching on alpha/beta separation in liquid scintillation counting for several high capacity cocktails

    International Nuclear Information System (INIS)

    Pujol, L.; Sanchez-Cabeza, J.-A.

    1997-01-01

    The optimization of alpha/beta separation in liquid scintillation using pulse shape analysis is convenient for the simultaneous determination of alpha and beta emitters in natural water and other samples. In this work, alpha/beta separation was studied for different scintillant/vial combinations and it was observed that both the optimum pulse shape discrimination level and the total interference value (that is, the summed relative interference between alpha and beta spectra) were dependent on the sample quenching and independent of the scintillant/vial combination. These results provide a simple method for modifying the counting configuration, such as a change in the cocktail, vial or sample characteristics, without the need to perform exhaustive parameter optimizations. Also, it was observed that, for our counting conditions, the combination of Ultima Gold AB scintillation cocktail with Zinsser low diffusion vials presented the lowest total interference, namely 0.94 ± 0.28%, which is insignificant for the counting of environmental samples. (Author)

  5. Coaching the alpha male.

    Science.gov (United States)

    Ludeman, Kate; Erlandson, Eddie

    2004-05-01

    Highly intelligent, confident, and successful, alpha males represent about 70% of all senior executives. Natural leaders, they willingly take on levels of responsibility most rational people would find overwhelming. But many of their quintessential strengths can also make alphas difficult to work with. Their self-confidence can appear domineering. Their high expectations can make them excessively critical. Their unemotional style can keep them from inspiring their teams. That's why alphas need coaching to broaden their interpersonal tool kits while preserving their strengths. Drawing from their experience coaching more than 1,000 senior executives, the authors outline an approach tailored specifically for the alpha. Coaches get the alpha's attention by inundating him with data from 360-degree feedback presented in ways he will find compelling--both hard-boiled metrics and vivid verbatim comments from colleagues about his strengths and weaknesses. A 360-degree assessment is a wake-up call for most alphas, providing undeniable proof that their behavior doesn't work nearly as well as they think it does. That paves the way for a genuine commitment to change. In order to change, the alpha must venture into unfamiliar--and often uncomfortable--psychological territory. He must admit vulnerability, accept accountability not just for his own work for others', connect with his underlying emotions, learn to motivate through a balance of criticism and validation, and become aware of unproductive behavior patterns. The goal of executive coaching is not simply to treat the alpha as an individual problem but to improve the entire team dynamic. Initial success creates an incentive to persevere, and the virtuous cycle reverberates throughout the entire organization.

  6. Hamburg Accelerator Conference (2)

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Edmund J.N. [CERN Accelerator School (Switzerland)

    1992-11-15

    From 20-24 July, Hamburg welcomed the Fifteenth International Conference on High Energy Accelerators (HEACC). The HEACC Conference traditionally reviews the status of all major accelerator projects whether they are already running like clockwork, still in the construction phase, or waiting impatiently for financial approval.

  7. Hamburg Accelerator Conference (2)

    International Nuclear Information System (INIS)

    Wilson, Edmund J.N.

    1992-01-01

    From 20-24 July, Hamburg welcomed the Fifteenth International Conference on High Energy Accelerators (HEACC). The HEACC Conference traditionally reviews the status of all major accelerator projects whether they are already running like clockwork, still in the construction phase, or waiting impatiently for financial approval

  8. High strength, biodegradable and cytocompatible alpha tricalcium phosphate-iron composites for temporal reduction of bone fractures.

    Science.gov (United States)

    Montufar, E B; Casas-Luna, M; Horynová, M; Tkachenko, S; Fohlerová, Z; Diaz-de-la-Torre, S; Dvořák, K; Čelko, L; Kaiser, J

    2018-04-01

    In this work alpha tricalcium phosphate (α-TCP)/iron (Fe) composites were developed as a new family of biodegradable, load-bearing and cytocompatible materials. The composites with composition from pure ceramic to pure metallic samples were consolidated by pulsed electric current assisted sintering to minimise processing time and temperature while improving their mechanical performance. The mechanical strength of the composites was increased and controlled with the Fe content, passing from brittle to ductile failure. In particular, the addition of 25 vol% of Fe produced a ceramic matrix composite with elastic modulus much closer to cortical bone than that of titanium or biodegradable magnesium alloys and specific compressive strength above that of stainless steel, chromium-cobalt alloys and pure titanium, currently used in clinic for internal fracture fixation. All the composites studied exhibited higher degradation rate than their individual components, presenting values around 200 μm/year, but also their compressive strength did not show a significant reduction in the period required for bone fracture consolidation. Composites showed preferential degradation of α-TCP areas rather than β-TCP areas, suggesting that α-TCP can produce composites with higher degradation rate. The composites were cytocompatible both in indirect and direct contact with bone cells. Osteoblast-like cells attached and spread on the surface of the composites, presenting proliferation rate similar to cells on tissue culture-grade polystyrene and they showed alkaline phosphatase activity. Therefore, this new family of composites is a potential alternative to produce implants for temporal reduction of bone fractures. Biodegradable alpha-tricalcium phosphate/iron (α-TCP/Fe) composites are promising candidates for the fabrication of temporal osteosynthesis devices. Similar to biodegradable metals, these composites can avoid implant removal after bone fracture healing, particularly in

  9. Loss of a highly conserved sterile alpha motif domain gene (WEEP) results in pendulous branch growth in peach trees.

    Science.gov (United States)

    Hollender, Courtney A; Pascal, Thierry; Tabb, Amy; Hadiarto, Toto; Srinivasan, Chinnathambi; Wang, Wanpeng; Liu, Zhongchi; Scorza, Ralph; Dardick, Chris

    2018-05-15

    Plant shoots typically grow upward in opposition to the pull of gravity. However, exceptions exist throughout the plant kingdom. Most conspicuous are trees with weeping or pendulous branches. While such trees have long been cultivated and appreciated for their ornamental value, the molecular basis behind the weeping habit is not known. Here, we characterized a weeping tree phenotype in Prunus persica (peach) and identified the underlying genetic mutation using a genomic sequencing approach. Weeping peach tree shoots exhibited a downward elliptical growth pattern and did not exhibit an upward bending in response to 90° reorientation. The causative allele was found to be an uncharacterized gene, Ppa013325 , having a 1.8-Kb deletion spanning the 5' end. This gene, dubbed WEEP , was predominantly expressed in phloem tissues and encodes a highly conserved 129-amino acid protein containing a sterile alpha motif (SAM) domain. Silencing WEEP in the related tree species Prunus domestica (plum) resulted in more outward, downward, and wandering shoot orientations compared to standard trees, supporting a role for WEEP in directing lateral shoot growth in trees. This previously unknown regulator of branch orientation, which may also be a regulator of gravity perception or response, provides insights into our understanding of how tree branches grow in opposition to gravity and could serve as a critical target for manipulating tree architecture for improved tree shape in agricultural and horticulture applications. Copyright © 2018 the Author(s). Published by PNAS.

  10. A static investigation of the thrust vectoring system of the F/A-18 high-alpha research vehicle

    Science.gov (United States)

    Mason, Mary L.; Capone, Francis J.; Asbury, Scott C.

    1992-01-01

    A static (wind-off) test was conducted in the static test facility of the Langley 16-foot Transonic Tunnel to evaluate the vectoring capability and isolated nozzle performance of the proposed thrust vectoring system of the F/A-18 high alpha research vehicle (HARV). The thrust vectoring system consisted of three asymmetrically spaced vanes installed externally on a single test nozzle. Two nozzle configurations were tested: A maximum afterburner-power nozzle and a military-power nozzle. Vane size and vane actuation geometry were investigated, and an extensive matrix of vane deflection angles was tested. The nozzle pressure ratios ranged from two to six. The results indicate that the three vane system can successfully generate multiaxis (pitch and yaw) thrust vectoring. However, large resultant vector angles incurred large thrust losses. Resultant vector angles were always lower than the vane deflection angles. The maximum thrust vectoring angles achieved for the military-power nozzle were larger than the angles achieved for the maximum afterburner-power nozzle.

  11. Effect of alpha and gamma radiation on the near-field chemistry and geochemistry of high-level waste packages

    International Nuclear Information System (INIS)

    Reed, D.T.

    1985-12-01

    Ionizing radiation can potentially alter geochemical and chemical processes in a geologic system. These effects can either enhance or reduce the performance of the waste package in a deep geologic repository. Current indications are that, in a repository located in basalt, ionizing radiation significantly affects geochemical/chemical processes but does not appear to significantly affect factors important to the long-term performance of the repository. The experimental results presented in this paper were obtained as part of an ongoing effort by the Basalt Waste Isolation Project to determine the effect of ionizing radiation on chemical and geochemical processes in the environment of the waste package. Gamma radiolysis experiments were done by subjecting samples of synthetic basalt groundwater in the presence of various waste package components (basalt/packing/low-carbon steel) to high levels of gamma radiation from a 60 Co source. Post-irradiation analysis was done on the gas, liquid, and solid components of the basalt system. The results obtained are important in evaluating waste package performance during the containment period. The effect of alpha radiation on the basalt groundwater system in the presence of waste package components is important in evaluating waste package performance during the isolation period. The experimental work in this area is in a very preliminary stage. Results from two experiments are reported. 9 refs., 4 figs., 7 tabs

  12. Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye

    Directory of Open Access Journals (Sweden)

    Sarezky D

    2016-09-01

    Full Text Available Daniel Sarezky, Aaishah R Raquib, Joshua L Dunaief, Benjamin J Kim Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Purpose: Alpha lipoic acid (ALA is an antioxidant and iron-chelating supplement that has potential benefits for geographic atrophy in dry age-related macular degeneration as well as other eye diseases. The purpose of this study was to determine the tolerability of ALA in the elderly population. Patients and methods: Fifteen subjects, age ≥65 years, took sequential ALA doses of 600, 800, and 1,200 mg. Each dose was taken once daily with a meal for 5 days. After each dose was taken by the subjects for 5 days, the subjects were contacted by phone, a review of systems was performed, and they were asked if they thought they could tolerate taking that dose of ALA for an extended period of time. Results: The 600 mg dose was well tolerated. At the 800 mg dose, one subject had an intolerable flushing sensation. At the 1,200 mg dose, two subjects had intolerable upper gastrointestinal side effects and one subject had an intolerable flushing sensation. Subjects taking gastrointestinal prophylaxis medications had no upper gastrointestinal side effects. Conclusion: High-dose ALA is not completely tolerated by the elderly. These preliminary data suggest that gastrointestinal prophylaxis may improve tolerability. (ClinicalTrials.gov, NCT02613572. Keywords: age-related macular degeneration, geographic atrophy, antioxidant, gastrointestinal, dietary supplements, lipoic acid

  13. Guidelines for the operation and closure of deep geological repositories for the disposal of high level and alpha bearing wastes

    International Nuclear Information System (INIS)

    1991-10-01

    The operation and closure of a deep geological repository for the disposal of high level and alpha bearing wastes is a long term project involving many disciplines. This unique combination of nuclear operations in a deep underground location will require careful planning by the operating organization. The basic purpose of the operation stage of the deep repository is to ensure the safe disposal of the radioactive wastes. The purpose of the closure stage is to ensure that the wastes are safely isolated from the biosphere, and that the surface region can be returned to normal use. During these two stages of operation and closure, it is essential that both workers and the public are safely protected from radiation hazards, and that workers are protected from the hazards of working underground. For these periods of the repository, it is essential to carry out monitoring for purposes of radiological protection, and to continue testing and investigations to provide data for repository performance confirmation and for final safety assessment. Over the lengthy stages of operation and closure, there will be substantial feedback of experience and generation of site data. These will lead both to improved quality of operation and a better understanding of the site characteristics, thereby enhancing the confidence in the ability of the repository system to isolate the waste and protect future generations. 15 refs

  14. Transplastomic expression of bacterial L-aspartate-alpha-decarboxylase enhances photosynthesis and biomass production in response to high temperature stress.

    Science.gov (United States)

    Fouad, W M; Altpeter, F

    2009-10-01

    Metabolic engineering for beta-alanine over-production in plants is expected to enhance environmental stress tolerance. The Escherichia coli L-aspartate-alpha-decarboxylase (AspDC) encoded by the panD gene, catalyzes the decarboxylation of L-aspartate to generate beta-alanine and carbon dioxide. The constitutive E. coli panD expression cassette was co-introduced with the constitutive, selectable aadA expression cassette into the chloroplast genome of tobacco via biolistic gene transfer and homologous recombination. Site specific integration of the E. coli panD expression cassette into the chloroplast genome and generation of homotransplastomic plants were confirmed by PCR and Southern blot analysis, respectively, following plant regeneration and germination of seedlings on selective media. PanD expression was verified by assays based on transcript detection and in vitro enzyme activity. The AspDC activities in transplastomic plants expressing panD were drastically increased by high-temperature stress. beta-Alanine accumulated in transplastomic plants at levels four times higher than in wildtype plants. Analysis of chlorophyll fluorescence on plants subjected to severe heat stress at 45 degrees C under light verified that photosystem II (PSII) in transgenic plants had higher thermotolerance than in wildtype plants. The CO(2) assimilation of transplastomic plants expressing panD was more tolerant to high temperature stress than that of wildtype plants, resulting in the production of 30-40% more above ground biomass than wildtype control. The results presented indicate that chloroplast engineering of the beta-alanine pathway by over-expression of the E. coli panD enhances thermotolerance of photosynthesis and biomass production following high temperature stress.

  15. Book of abstracts of the international conference on high levels of natural radiation held in Ramsar, Islamic Republic of Iran, 3-7 Nov 1990

    International Nuclear Information System (INIS)

    Sohrabi, M.; Borhan Azad, S.; Katouzi, M.

    1990-01-01

    Papers presented in international conference on high levels of natural radiation was in the following subjects: A review of world natural radiation, environmental transfer pathway,technologically enhanced natural radiation environment,radon in the environment,radium determination in water,cytogenetic studies in high natural radiation areas,epidemiological studies in high natural radiation areas and radiation measurements methods

  16. A synthetic arabinose-inducible promoter confers high levels of recombinant protein expression in hyperthermophilic archaeon Sulfolobus islandicus

    DEFF Research Database (Denmark)

    Peng, Nan; Deng, Ling; Mei, Yuxia

    2012-01-01

    Despite major progresses in genetic studies of hyperthermophilic archaea, recombinant protein production in these organisms always suffers from low yields and a robust expression system is still in great demand. Here we report a versatile vector that confers high levels of protein expression...... to remove the peptide tags from expressed recombinant proteins. While pEXA employed an araS promoter for protein expression, pSeSD utilized P(araS-SD), an araS derivative promoter carrying an engineered ribosome-binding site (RBS; a Shine-Dalgarno [SD] sequence). We found that P(araS-SD) directed high...... levels of target gene expression. More strikingly, N-terminal amino acid sequencing of recombinant proteins unraveled that the protein synthesized from pEXA-N-lacS lacked the designed 6×His tag and that translation initiation did not start at the ATG codon of the fusion gene. Instead, it started...

  17. [Genetic cloning and expression of hypoxia inducible factor 1 alpha in high altitude hypoxic adaptation species Tibetan antelope (Pantholops hodgsonii)].

    Science.gov (United States)

    Liu, Fang; Wuren, Tana; Ma, Lan; Yang, Ying-Zhong; Ge, Ri-Li

    2011-12-25

    In order to investigate the role of the hypoxia inducible factor 1 alpha (HIF-1α) in the adaptation mechanism to high altitude hypoxia, the cloning of the HIF-1α gene cDNA of Tibetan antelope (Pantholops hodgsonii), using RT-PCR and RACE, was applied, and the comparative analysis of the tissue-specific expressions of HIF-1α among Tibetan antelope, Tibetan sheep and plain sheep was performed using real-time PCR and Western blot. The sequence analysis indicated that the cDNA sequences acquired by cloning from the HIF-1α gene of Tibetan antelope comprised a 2 471-bp open reading frame (ORF) and a 1 911-bp 3'UTR. The similarity between its coding sequence, predicted amino acid sequence and HIF-1α of other mammals exceeded 87%, in which the similarity with cow was up to more than 98%, which showed that this sequence was the cDNA of HIF-1α of Tibetan antelope. The results of real-time PCR and Western blot showed that expressions of HIF-1α mRNA and protein appeared in Tibetan antelope's lung, cardiac muscle and skeletal muscle, with the highest expression in lung. HIF-1α mRNA and protein had obvious differential expression in these tissues. Further research showed that Tibetan antelope and Tibetan sheep possessed higher expressions of HIF-1α protein in the three tissues above-mentioned compared with plain sheep, and the expressions of HIF-1α mRNA and protein in Tibetan antelope's lung, cardiac muscle and skeletal muscle were higher than those of Tibetan sheep. It illustrates that the hypoxic HIF-1α-specific expression is one of the molecular bases of high altitude hypoxia adaptation in Tibetan antelope.

  18. Entrapment of alpha1-acid glycoprotein in high-performance affinity columns for drug-protein binding studies.

    Science.gov (United States)

    Bi, Cong; Jackson, Abby; Vargas-Badilla, John; Li, Rong; Rada, Giana; Anguizola, Jeanethe; Pfaunmiller, Erika; Hage, David S

    2016-05-15

    A slurry-based method was developed for the entrapment of alpha1-acid glycoprotein (AGP) for use in high-performance affinity chromatography to study drug interactions with this serum protein. Entrapment was achieved based on the physical containment of AGP in hydrazide-activated porous silica supports and by using mildly oxidized glycogen as a capping agent. The conditions needed for this process were examined and optimized. When this type of AGP column was used in binding studies, the association equilibrium constant (Ka) measured by frontal analysis at pH 7.4 and 37°C for carbamazepine with AGP was found to be 1.0 (±0.5)×10(5)M(-1), which agreed with a previously reported value of 1.0 (±0.1)×10(5)M(-1). Binding studies based on zonal elution were conducted for several other drugs with such columns, giving equilibrium constants that were consistent with literature values. An entrapped AGP column was also used in combination with a column containing entrapped HSA in a screening assay format to compare the binding of various drugs to AGP and HSA. These results also agreed with previous data that have been reported in literature for both of these proteins. The same entrapment method could be extended to other proteins and to the investigation of additional types of drug-protein interactions. Potential applications include the rapid quantitative analysis of biological interactions and the high-throughput screening of drug candidates for their binding to a given protein. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Munich conference

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1988-10-15

    'The Standard Model has survived impact for another year', declared Don Perkins of Oxford, summarizing the 24th International Conference on High Energy Physics held in Munich from 4-10 August. 'But is this a triumph or a frustration for physics?' he added. The twin pillars of the Standard Model, the electroweak unification of electromagnetism and the weak nuclear force, and the field theory (quantum chromodynamics) of the quark-gluon interactions responsible for the strong nuclear force, have not trembled since the electroweak unification went to the textbooks in 1983, but from time to time small cracks have appeared which might have gone on to shake the theory severely, if not undermine it. Major conference summarizers have got used to singing the praises of the Standard Model, but this year at Munich even detailed examination failed to reveal any serious cracks, while looking deeper into physics even some anomalous results hinting at gaps in understanding have either gone away or have diminished credibility.

  20. Munich conference

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    'The Standard Model has survived impact for another year', declared Don Perkins of Oxford, summarizing the 24th International Conference on High Energy Physics held in Munich from 4-10 August. 'But is this a triumph or a frustration for physics?' he added. The twin pillars of the Standard Model, the electroweak unification of electromagnetism and the weak nuclear force, and the field theory (quantum chromodynamics) of the quark-gluon interactions responsible for the strong nuclear force, have not trembled since the electroweak unification went to the textbooks in 1983, but from time to time small cracks have appeared which might have gone on to shake the theory severely, if not undermine it. Major conference summarizers have got used to singing the praises of the Standard Model, but this year at Munich even detailed examination failed to reveal any serious cracks, while looking deeper into physics even some anomalous results hinting at gaps in understanding have either gone away or have diminished credibility

  1. Treatment of solid waste highly contaminated by alpha emitters: Recent developments of leaching process with continuous electrolyte regeneration

    International Nuclear Information System (INIS)

    Madic, C.; Lecomte, M.; Vigreux, B.

    1990-01-01

    Development of processes for leaching solid waste contaminated by alpha or alphaβgamma emitters has been pursued at the Nuclear Research Center in Fontenay-aux-Roses, France with the recent active commissioning of two pilot facilities: the Elise glove box system in February 1987 and the Prolixe shielded hot cell in March 1988. The Elise facility is designed to handle alpha waste and the Prolixe facility is designed to handle alphaβgamma waste. The common goal of the studies conducted in these facilities is to define the operating conditions for declassification of solid waste, i.e. to ensure that the alpha concentration of this waste will be less than 3.7 x 10 6 Bq/kg after treatment, packaging and decay prior to storage in surface repositories. The leaching process developed is mainly based on the continuous electrolytic regeneration of an aggressive agent, AgII, which can induce the dissolution of PuO 2 , the most difficult compound to remove from the solid waste. This paper summarizes recent achievements in the development of this process. 11 refs., 8 figs., 6 tabs

  2. Treatment of solid waste highly contaminated by alpha emitters: recent developments of leaching process with continuous electrolyte regeneration

    International Nuclear Information System (INIS)

    Madic, C.; Lecomte, M.

    1990-01-01

    Development of processes for leaching solid waste contaminated by alpha or alpha/beta/gamma emitters has been pursued at the Nuclear Research Center in Fontenay-aux-Roses, France with the recent active commissioning of two pilot facilities: the Elise glove box system in February 1987 and the Prolixe shielded hot cell in March 1988. The Elise facility is designed to handle alpha waste and the Prolixe facility is designed to handle alpha/beta/gamma waste. The common goal of the studies conducted in these facilities is to define the operating conditions for declassification of solid waste, i.e. to ensure that the alpha concentration of this waste will be less than 3.7 x 10 6 Bq/kg after treatment, packaging and decay prior to storage in surface repositories. The leaching process developed is mainly based on the continuous electrolytic regeneration of an aggressive agent, AgII, which can induce the dissolution of PuO 2 , the most difficult compound to remove from the solid waste. This paper summarizes recent achievements in the development of this process

  3. Japan Accelerator Conference

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    At the international level, the high energy accelerator scene evolves rapidly and the International Conference on High Energy Accelerators is where its strong pulse can best be felt. This year, the Conference was held for the first time in Japan, with the 14th meeting in the series having been hosted in August by the Japanese KEK National Laboratory for High Energy Physics, Tsukuba. The venue was a recognition of the premier accelerator physics and technology status achieved by this diligent nation

  4. Japan Accelerator Conference

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1989-11-15

    At the international level, the high energy accelerator scene evolves rapidly and the International Conference on High Energy Accelerators is where its strong pulse can best be felt. This year, the Conference was held for the first time in Japan, with the 14th meeting in the series having been hosted in August by the Japanese KEK National Laboratory for High Energy Physics, Tsukuba. The venue was a recognition of the premier accelerator physics and technology status achieved by this diligent nation.

  5. Alpha-emitters for medical therapy workshop

    International Nuclear Information System (INIS)

    Feinendegen, L.E.; McClure, J.J.

    1996-01-01

    A workshop on ''Alpha-Emitters for Medical Therapy'' was held May 30-31, 1996 in Denver Colorado to identify research goals and potential clinical needs for applying alpha-particle emitters and to provide DOE with sufficient information for future planning. The workshop was attended by 36 participants representing radiooncology, nuclear medicine, immunotherapy, radiobiology, molecular biology, biochemistry, radiopharmaceutical chemistry, dosimetry, and physics. This report provides a summary of the key points and recommendations arrived at during the conference

  6. Alpha-emitters for medical therapy workshop

    Energy Technology Data Exchange (ETDEWEB)

    Feinendegen, L.E.; McClure, J.J.

    1996-12-31

    A workshop on ``Alpha-Emitters for Medical Therapy`` was held May 30-31, 1996 in Denver Colorado to identify research goals and potential clinical needs for applying alpha-particle emitters and to provide DOE with sufficient information for future planning. The workshop was attended by 36 participants representing radiooncology, nuclear medicine, immunotherapy, radiobiology, molecular biology, biochemistry, radiopharmaceutical chemistry, dosimetry, and physics. This report provides a summary of the key points and recommendations arrived at during the conference.

  7. Changes in highly sensitive alpha-fetoprotein for the prediction of the outcome in patients with hepatocellular carcinoma after hepatectomy

    International Nuclear Information System (INIS)

    Toyoda, Hidenori; Kumada, Takashi; Tada, Toshifumi; Ito, Takanori; Maeda, Atsuyuki; Kaneoka, Yuji; Kagebayashi, Chiaki; Satomura, Shinji

    2014-01-01

    We investigated changes in highly sensitive lens culinaris agglutinin A-reactive fraction of alpha-fetoprotein (hsAFP-L3) measured using a novel method and its predictive ability for prognosis in patients with hepatocellular carcinoma (HCC) who underwent curative hepatectomy, comparing to other HCC tumor markers, that is, AFP, des-gamma-carboxy prothrombin (DCP), and AFP-L3 measured with conventional method (cAFP-L3). AFP, DCP, and AFP-L3 including both cAFP-L3 and hsAFP-L3 were measured before and after curative hepatectomy in 187 patients. The percentage of patients with elevated tumor marker levels pre- and postoperatively was compared, and recurrence-free and overall survival rates were analyzed based on changes in tumor markers. The percentages of patients with elevated AFP, DCP, and cAFP-L3 decreased postoperatively. In contrast, the percentage of patients with elevated hsAFP-L3 did not decrease postoperatively. Both recurrence-free and overall survival rates were significantly lower in patients whose tumor marker levels remained elevated postoperatively than patients without tumor marker elevation postoperatively. Recurrence-free and overall survival rates of patients in whom hsAFP-L3 became elevated postoperatively despite normal preoperative hsAFP-L3 levels were significantly lower than those of patients with normal hsAFP-L3 postoperatively, and were similar to those of patients with persistent elevation. Preoperative elevations of AFP, DCP, and cAFP normalized in many patients postoperatively, but not for hsAFP-L3. The elevation of hsAFP-L3 identifies patients with poor prognosis despite the normalization of AFP and DCP

  8. Intenational conference on high-energy physics. Volume 2. Sessions IV to VIII. [Geneva, June 27-July 4, 1979

    Energy Technology Data Exchange (ETDEWEB)

    1980-02-01

    Volume 2 of the conference proceedings contains sessions on hadron physics, charged-lepton physics, the p-p-bar collider at CERN, future European accelerator possibilities, parallel discussion sessions (on high-energy) hadron-induced reactions, deep inelastic phenomena, hadron spectroscopy, weak ineractions and gauge theories, and quark confinement), and a closing session on gauge appreciation of developments in particle physics. A list of participants is also included. Three of the papers in this volume have already been cited in ERA, and can be found as reference to the entry CONF-790642-- in the Report Number Index. The remaining 36 will be processed as they are received on the Atomindex tape. (RWR)

  9. Subtle Hepatocellular Carcinoma: A Persisting Role for Alpha-Fetoprotein Monitoring in High-Risk Patients with Cirrhosis

    Directory of Open Access Journals (Sweden)

    Barry Schlansky

    2011-10-01

    Full Text Available Hepatocellular carcinoma (HCC is a common, aggressive malignancy that usually develops in a background of liver cirrhosis. Practice guidelines recommend screening of cirrhotic patients with ultrasound and more detailed imaging (computed tomography or magnetic resonance imaging if abnormalities are detected. The utility of alpha-fetoprotein levels in HCC surveillance is controversial. Although HCC risk differs by etiology of cirrhosis, screening and surveillance guidelines are uniform after cirrhosis is established. We report a case of rapidly progressive HCC occurring in a cirrhotic patient with multiple unique risk factors for neoplasia, detected by a rising alpha-fetoprotein level without imaging features of liver cancer.

  10. National Conference on High Blood Pressure Control in Native American Communities (2nd, Tulsa, Oklahoma, November 6-7, 1980). Summary Report.

    Science.gov (United States)

    National Heart and Lung Inst. (DHHS/NIH), Bethesda, MD. National High Blood Pressure Education Program.

    As part of the National High Blood Pressure Education Program effort, the conference explored the impact of high blood pressure (hypertension) on Native Americans. Participants, including health professionals, health service consumers, and volunteers providing health services to Native Americans, discussed these issues: traditional Native American…

  11. Abstracts of International Conference on Experimental and Computing Methods in High Resolution Diffraction Applied for Structure Characterization of Modern Materials - HREDAMM

    International Nuclear Information System (INIS)

    2004-01-01

    The conference addressed all aspects of high resolution diffraction. The topics of meeting include advanced experimental diffraction methods and computer data analysis for characterization of modern materials as well as the progress and new achievements in high resolution diffraction (X-ray, electrons, neutrons). Application of these methods for characterization of modern materials are widely presented among the invited, oral and poster contributions

  12. Treatment of alpha bearing wastes

    International Nuclear Information System (INIS)

    1988-01-01

    This report deals with the current state of the art of alpha waste treatment, which is an integral part of the overall nuclear waste management system. The International Atomic Energy Agency (IAEA) defines alpha bearing waste as 'waste containing one or more alpha emitting radionuclides, usually actinides, in quantities above acceptable limits'. The limits are established by national regulatory bodies. The limits above which wastes are considered as alpha contaminated refer to the concentrations of alpha emitters that need special consideration for occupational exposures and/or potential safety, health, or environmental impact during one or more steps from generation through disposal. Owing to the widespread use of waste segregation by source - that is, based upon the 'suspect origin' of the material - significant volumes of waste are being handled as alpha contaminated which, in fact, do not require such consideration by reason of risk or environmental concern. The quantification of de minimis concepts by national regulatory bodies could largely contribute to the safe reduction of waste volumes and associated costs. Other factors which could significantly contribute to the reduction of alpha waste arisings are an increased application of assaying and sorting, instrumentation and the use of feedback mechanisms to control or modify the processes which generate these wastes. Alpha bearing wastes are generated during fabrication and reprocessing of nuclear fuels, decommissioning of alpha contaminated facilities, and other activities. Most alpha wastes are contact handled, but a small portion may require shielding or remote handling because of high levels of neutron (n), beta (β), or gamma (γ) emissions associated with the waste material. This report describes the sources and characteristics of alpha wastes and strategies for alpha waste management. General descriptions of treatment processes for solid and liquid alpha wastes are included. 71 refs, 14 figs, 9 tabs

  13. Conference summaries

    International Nuclear Information System (INIS)

    1991-01-01

    This volume contains conference summaries for the 31. annual conference of the Canadian Nuclear Association and the 12. annual conference of the Canadian Nuclear Society. Topics of discussion include: reactor physics; thermalhydraulics; industrial irradiation; computer applications; fuel channel analysis; small reactors; severe accidents; fuel behaviour under accident conditions; reactor components, safety related computer software; nuclear fuel management; fuel behaviour and performance; reactor safety; reactor engineering; nuclear waste management; and, uranium mining and processing

  14. INTERCARTO CONFERENCES

    OpenAIRE

    Vladimir Tikunov

    2010-01-01

    The InterCarto conferences are thematically organized to target one of the most pressing problems of modern geography—creation and use of geographical information systems (GISs) as effective tools for achieving sustainable development of territories. Over the years, from 1994 to 2009, 1872 participants from 51 countries and 156 cities, who made 1494 reports, attended the conferences. There were 1508 participants from 49 regions of Russia making 1340 presentations. The conferences hosted 31 di...

  15. Regional Patterns of Elevated Alpha and High-Frequency Electroencephalographic Activity during Nonrapid Eye Movement Sleep in Chronic Insomnia: A Pilot Study

    Science.gov (United States)

    Riedner, Brady A.; Goldstein, Michael R.; Plante, David T.; Rumble, Meredith E.; Ferrarelli, Fabio; Tononi, Giulio; Benca, Ruth M.

    2016-01-01

    Study Objectives: To examine nonrapid eye movement (NREM) sleep in insomnia using high-density electroencephalography (EEG). Methods: All-night sleep recordings with 256 channel high-density EEG were analyzed for 8 insomnia subjects (5 females) and 8 sex and age-matched controls without sleep complaints. Spectral analyses were conducted using unpaired t-tests and topographical differences between groups were assessed using statistical non-parametric mapping. Five minute segments of deep NREM sleep were further analyzed using sLORETA cortical source imaging. Results: The initial topographic analysis of all-night NREM sleep EEG revealed that insomnia subjects had more high-frequency EEG activity (> 16 Hz) compared to good sleeping controls and that the difference between groups was widespread across the scalp. In addition, the analysis also showed that there was a more circumscribed difference in theta (4–8 Hz) and alpha (8–12 Hz) power bands between groups. When deep NREM sleep (N3) was examined separately, the high-frequency difference between groups diminished, whereas the higher regional alpha activity in insomnia subjects persisted. Source imaging analysis demonstrated that sensory and sensorimotor cortical areas consistently exhibited elevated levels of alpha activity during deep NREM sleep in insomnia subjects relative to good sleeping controls. Conclusions: These results suggest that even during the deepest stage of sleep, sensory and sensorimotor areas in insomnia subjects may still be relatively active compared to control subjects and to the rest of the sleeping brain. Citation: Riedner BA, Goldstein MR, Plante DT, Rumble ME, Ferrarelli F, Tononi G, Benca RM. Regional patterns of elevated alpha and high-frequency electroencephalographic activity during nonrapid eye movement sleep in chronic insomnia: a pilot study. SLEEP 2016;39(4):801–812. PMID:26943465

  16. Regional Patterns of Elevated Alpha and High-Frequency Electroencephalographic Activity during Nonrapid Eye Movement Sleep in Chronic Insomnia: A Pilot Study.

    Science.gov (United States)

    Riedner, Brady A; Goldstein, Michael R; Plante, David T; Rumble, Meredith E; Ferrarelli, Fabio; Tononi, Giulio; Benca, Ruth M

    2016-04-01

    To examine nonrapid eye movement (NREM) sleep in insomnia using high-density electroencephalography (EEG). All-night sleep recordings with 256 channel high-density EEG were analyzed for 8 insomnia subjects (5 females) and 8 sex and age-matched controls without sleep complaints. Spectral analyses were conducted using unpaired t-tests and topographical differences between groups were assessed using statistical non-parametric mapping. Five minute segments of deep NREM sleep were further analyzed using sLORETA cortical source imaging. The initial topographic analysis of all-night NREM sleep EEG revealed that insomnia subjects had more high-frequency EEG activity (> 16 Hz) compared to good sleeping controls and that the difference between groups was widespread across the scalp. In addition, the analysis also showed that there was a more circumscribed difference in theta (4-8 Hz) and alpha (8-12 Hz) power bands between groups. When deep NREM sleep (N3) was examined separately, the high-frequency difference between groups diminished, whereas the higher regional alpha activity in insomnia subjects persisted. Source imaging analysis demonstrated that sensory and sensorimotor cortical areas consistently exhibited elevated levels of alpha activity during deep NREM sleep in insomnia subjects relative to good sleeping controls. These results suggest that even during the deepest stage of sleep, sensory and sensorimotor areas in insomnia subjects may still be relatively active compared to control subjects and to the rest of the sleeping brain. © 2016 Associated Professional Sleep Societies, LLC.

  17. Eosinophils from patients with type 1 diabetes mellitus express high level of myeloid alpha-defensins and myeloperoxidase

    Czech Academy of Sciences Publication Activity Database

    Neuwirth, Aleš; Dobeš, Jan; Oujezdská, Jana; Ballek, Ondřej; Benešová, Martina; Sumnik, Z.; Včeláková, J.; Koloušková, S.; Obermannová, B.; Kolář, Michal; Štechová, K.; Filipp, Dominik

    2012-01-01

    Roč. 273, č. 2 (2012), s. 158-163 ISSN 0008-8749 R&D Projects: GA MŠk 2B08066 Institutional research plan: CEZ:AV0Z50520514 Keywords : type 1 diabetes * alpha-defensin * myeloperoxidase * granulocyte * eosinophil Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.743, year: 2012

  18. Dietary alpha-cyclodextrin lowers LDL-C and alters plasma fatty acid profile in LDLr-KO mice on a high-fat diet

    OpenAIRE

    Wagner, Elke M.; Catherine Jen, K-L; Artiss, Joseph D.; Remaley, Alan T.

    2008-01-01

    High dietary intake of saturated fat and cholesterol, and elevated low-density-lipoprotein (LDL) cholesterol levels are some of the modifiable risk factors for cardiovascular disease (CVD). Alpha-cyclodextrin (α-CD) when given orally has been shown in rats to increase fecal saturated fat excretion, and to reduce blood total cholesterol levels in obese hypertriglyceridemic subjects with type 2 diabetes. In this study, the effects of dietary α-CD on lipid metabolism in LDL receptor knock-out (L...

  19. Production of enzymatically active recombinant full-length barley high pI alpha-glucosidase of glycoside family 31 by high cell-density fermentation of Pichia pastoris and affinity purification

    DEFF Research Database (Denmark)

    Næsted, Henrik; Kramhøft, Birte; Lok, F.

    2006-01-01

    Recombinant barley high pI alpha-glucosidase was produced by high cell-density fermentation of Pichia pastoris expressing the cloned full-length gene. The gene was amplified from a genomic clone and exons (coding regions) were assembled by overlap PCR. The resulting cDNA was expressed under contr...... nM x s(-1), and 85 s(-1) using maltose as substrate. This work presents the first production of fully active recombinant alpha-glucosidase of glycoside hydrolase family 31 from higher plants. (c) 2005 Elsevier Inc. All rights reserved....

  20. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ( 211 At) and natural bismuth-212 ( 212 Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ( 223 Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  1. Proteinaceous alpha-araylase inhibitors

    DEFF Research Database (Denmark)

    Svensson, Birte; Fukuda, Kenji; Nielsen, P.K.

    2004-01-01

    -amylase inhibitors belong to seven different protein structural families, most of which also contain evolutionary related proteins without inhibitory activity. Two families include bifunctional inhibitors acting both on alpha-amylases and proteases. High-resolution structures are available of target alpha...

  2. Proceedings of the eleventh international conference on high nitrogen steels and interstitial alloys: souvenir

    International Nuclear Information System (INIS)

    2012-01-01

    Stainless steels serve a multitude of applications from brightly polished consumer products to machinery and equipment for challenging industrial environments. Improvements of mechanical and corrosion properties of stainless steels and a whole spectrum of steels for high pressure and high temperature applications, necessitated development of new elegant class of High Nitrogen Steels (HNS). Presently high nitrogen steels occupy a centre stage in many strategic industries like power, oil and gas and infrastructure etc. In nuclear industry, in the demanding environments of fuel reprocessing and waste managing plants HNS can find possible applications. Already nitrogen alloyed stainless steel has found its niche as structural material of Fast Breeder Reactors and Advanced Heavy Water Reactor in India. Nitrogen is also an important alloying element in the new generation ferritic steels meant for high temperature applications. Papers relevant to INIS are indexed separately

  3. High impact ionization rate in silicon by sub-picosecond THz electric field pulses (Conference Presentation)

    DEFF Research Database (Denmark)

    Tarekegne, Abebe Tilahun; Iwaszczuk, Krzysztof; Hirori, Hideki

    2017-01-01

    Summary form only given. Metallic antenna arrays fabricated on high resistivity silicon are used to localize and enhance the incident THz field resulting in high electric field pulses with peak electric field strength reaching several MV/cm on the silicon surface near the antenna tips. In such high...... electric field strengths high density of carriers are generated in silicon through impact ionization process. The high density of generated carriers induces a change of refractive index in silicon. By measuring the change of reflectivity of tightly focused 800 nm light, the local density of free carriers...... near the antenna tips is measured. Using the NIR probing technique, we observed that the density of carriers increases by over 8 orders of magnitude in a time duration of approximately 500 fs with an incident THz pulse of peak electric field strength 700 kV/cm. This shows that a single impact...

  4. Conference summaries

    International Nuclear Information System (INIS)

    1986-01-01

    This volume contains conference summaries of the international conference on radioactive waste management of the Canadian Nuclear Society. Topics of discussion include: storage and disposal; hydrogeology and geochemistry; transportation; buffers and backfill; public attitudes; tailings; site investigations and geomechanics; concrete; economics; licensing; matrix materials and container design; durability of fuel; biosphere modelling; radioactive waste processing; and, future options

  5. Conference summaries

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, Tim [Inta Communication Limited for European Service Network/ DG Research, Trillium House, 32 New Street, St. Neots, Cambridge PE19 1AJ (United Kingdom)

    2004-07-01

    The summaries were derived from presentations, interviews and discussions at the conference. The summaries are given at two levels, overall for the conference and for specific sessions as follows: 1) Overall Conference: 'A Sound Scientific Basis for Serious Decisions; 2) Sessions on EC Policy and Socio-Political Issues: 'Promoting Safety and Protecting Society'; 3) Session on P and T: 'Partitioning and Transmutation: A Technical Fix or Technical Training?'; 4) Sessions on Geological Disposal and Research Networking: 'No Technical Barriers to Geological Disposal'. First an overall summary of Euradwaste '04 is presented. Significant progress was made on the technical and scientific basis for geological disposal of radioactive waste during the European Commission's Fifth EURATOM Framework Programme for Research (FP5). Deep geological disposal is technically feasible now and can demonstrate the guarantees of long-term isolation and protection of the public. In parallel, socio-political studies have produced methodologies for constructive dialogue with potential host communities that reflect the honesty and openness expected by a democratic society. A harmonized legislative framework for nuclear safety and waste disposal across the enlarged European Union is currently being discussed. Disposal in deep (> 300 metre) geological repositories, the favoured strategy in Europe for long-lived high-level radioactive waste, is now possible. The Sessions on EC Policy and Socio-Political Issues are summarized as follows. The opening day of Euradwaste '04 focused on European Commission policy, including the proposed Directives on disposal of radioactive waste and nuclear safety and socio-political aspects including governance and decision making, public perception/acceptance of waste disposal and its sustainability. A decision on the proposed package will now be made after Union enlargement. Public agreement on the siting of

  6. 4TH International Conference on High-Temperature Ceramic Matrix Composites

    National Research Council Canada - National Science Library

    2001-01-01

    .... Topic to be covered include fibers, interfaces, interphases, non-oxide ceramic matrix composites, oxide/oxide ceramic matrix composites, coatings, and applications of high-temperature ceramic matrix...

  7. INTERCARTO CONFERENCES

    Directory of Open Access Journals (Sweden)

    Vladimir Tikunov

    2010-01-01

    Full Text Available The InterCarto conferences are thematically organized to target one of the most pressing problems of modern geography—creation and use of geographical information systems (GISs as effective tools for achieving sustainable development of territories. Over the years, from 1994 to 2009, 1872 participants from 51 countries and 156 cities, who made 1494 reports, attended the conferences. There were 1508 participants from 49 regions of Russia making 1340 presentations. The conferences hosted 31 different sections, most popular of which were Environmental GIS-Projects: Development and Experience, Sustainable Development and Innovative Projects, GIS: the Theory and Methodology, Projects for Russia and Regions, and GIS-Technologies and Digital Mapping. The next annual InterCarto-InterGIS conference will take place in December 2011. The Russian component of the conference will be held in the Altay Kray followed by another meeting on Bali, Indonesia

  8. California Conference on High Blood Pressure Control in the Spanish-Speaking Community (Los Angeles, California, April 1-2, 1978). Summary Report.

    Science.gov (United States)

    National Institutes of Health (DHEW), Bethesda, MD. High Blood Pressure Information Center.

    As part of the National High Blood Pressure Education Program effort, the conference explored the implications and impact of the prevalence of hypertension in Spanish-speaking populations in California. Approximately 150 experts in health fields, representing all levels of government, public and private health care providers, consumers, and health…

  9. Depth-resolved incoherent and coherent wide-field high-content imaging (Conference Presentation)

    Science.gov (United States)

    So, Peter T.

    2016-03-01

    Recent advances in depth-resolved wide-field imaging technique has enabled many high throughput applications in biology and medicine. Depth resolved imaging of incoherent signals can be readily accomplished with structured light illumination or nonlinear temporal focusing. The integration of these high throughput systems with novel spectroscopic resolving elements further enable high-content information extraction. We will introduce a novel near common-path interferometer and demonstrate its uses in toxicology and cancer biology applications. The extension of incoherent depth-resolved wide-field imaging to coherent modality is non-trivial. Here, we will cover recent advances in wide-field 3D resolved mapping of refractive index, absorbance, and vibronic components in biological specimens.

  10. High speed all optical shear wave imaging optical coherence elastography (Conference Presentation)

    Science.gov (United States)

    Song, Shaozhen; Hsieh, Bao-Yu; Wei, Wei; Shen, Tueng; O'Donnell, Matthew; Wang, Ruikang K.

    2016-03-01

    Optical Coherence Elastography (OCE) is a non-invasive testing modality that maps the mechanical property of soft tissues with high sensitivity and spatial resolution using phase-sensitive optical coherence tomography (PhS-OCT). Shear wave OCE (SW-OCE) is a leading technique that relies on the speed of propagating shear waves to provide a quantitative elastography. Previous shear wave imaging OCT techniques are based on repeated M-B scans, which have several drawbacks such as long acquisition time and repeated wave stimulations. Recent developments of Fourier domain mode-locked high-speed swept-source OCT system has enabled enough speed to perform KHz B-scan rate OCT imaging. Here we propose ultra-high speed, single shot shear wave imaging to capture single-shot transient shear wave propagation to perform SW-OCE. The frame rate of shear wave imaging is 16 kHz, at A-line rate of ~1.62 MHz, which allows the detection of high-frequency shear wave of up to 8 kHz. The shear wave is generated photothermal-acoustically, by ultra-violet pulsed laser, which requires no contact to OCE subjects, while launching high frequency shear waves that carries rich localized elasticity information. The image acquisition and processing can be performed at video-rate, which enables real-time 3D elastography. SW-OCE measurements are demonstrated on tissue-mimicking phantoms and porcine ocular tissue. This approach opens up the feasibility to perform real-time 3D SW-OCE in clinical applications, to obtain high-resolution localized quantitative measurement of tissue biomechanical property.

  11. High-speed ultrafast laser machining with tertiary beam positioning (Conference Presentation)

    Science.gov (United States)

    Yang, Chuan; Zhang, Haibin

    2017-03-01

    For an industrial laser application, high process throughput and low average cost of ownership are critical to commercial success. Benefiting from high peak power, nonlinear absorption and small-achievable spot size, ultrafast lasers offer advantages of minimal heat affected zone, great taper and sidewall quality, and small via capability that exceeds the limits of their predecessors in via drilling for electronic packaging. In the past decade, ultrafast lasers have both grown in power and reduced in cost. For example, recently, disk and fiber technology have both shown stable operation in the 50W to 200W range, mostly at high repetition rate (beyond 500 kHz) that helps avoid detrimental nonlinear effects. However, to effectively and efficiently scale the throughput with the fast-growing power capability of the ultrafast lasers while keeping the beneficial laser-material interactions is very challenging, mainly because of the bottleneck imposed by the inertia-related acceleration limit and servo gain bandwidth when only stages and galvanometers are being used. On the other side, inertia-free scanning solutions like acoustic optics and electronic optical deflectors have small scan field, and therefore not suitable for large-panel processing. Our recent system developments combine stages, galvanometers, and AODs into a coordinated tertiary architecture for high bandwidth and meanwhile large field beam positioning. Synchronized three-level movements allow extremely fast local speed and continuous motion over the whole stage travel range. We present the via drilling results from such ultrafast system with up to 3MHz pulse to pulse random access, enabling high quality low cost ultrafast machining with emerging high average power laser sources.

  12. High-radiance LDP source for mask inspection and beam line applications (Conference Presentation)

    Science.gov (United States)

    Teramoto, Yusuke; Santos, Bárbara; Mertens, Guido; Kops, Ralf; Kops, Margarete; von Wezyk, Alexander; Bergmann, Klaus; Yabuta, Hironobu; Nagano, Akihisa; Ashizawa, Noritaka; Taniguchi, Yuta; Yamatani, Daiki; Shirai, Takahiro; Kasama, Kunihiko

    2017-04-01

    High-throughput actinic mask inspection tools are needed as EUVL begins to enter into volume production phase. One of the key technologies to realize such inspection tools is a high-radiance EUV source of which radiance is supposed to be as high as 100 W/mm2/sr. Ushio is developing laser-assisted discharge-produced plasma (LDP) sources. Ushio's LDP source is able to provide sufficient radiance as well as cleanliness, stability and reliability. Radiance behind the debris mitigation system was confirmed to be 120 W/mm2/sr at 9 kHz and peak radiance at the plasma was increased to over 200 W/mm2/sr in the recent development which supports high-throughput, high-precision mask inspection in the current and future technology nodes. One of the unique features of Ushio's LDP source is cleanliness. Cleanliness evaluation using both grazing-incidence Ru mirrors and normal-incidence Mo/Si mirrors showed no considerable damage to the mirrors other than smooth sputtering of the surface at the pace of a few nm per Gpulse. In order to prove the system reliability, several long-term tests were performed. Data recorded during the tests was analyzed to assess two-dimensional radiance stability. In addition, several operating parameters were monitored to figure out which contributes to the radiance stability. The latest model that features a large opening angle was recently developed so that the tool can utilize a large number of debris-free photons behind the debris shield. The model was designed both for beam line application and high-throughput mask inspection application. At the time of publication, the first product is supposed to be in use at the customer site.

  13. Joint AIRAPT-25th and EHPRG-53rd International Conference on High Pressure Science and Technology

    Science.gov (United States)

    Syassen, Karl

    2017-10-01

    The AIRAPT arose as a scientific forum for discussions aiming to promote contacts and cooperation between scientists and organizations of different countries, to collect and disseminate of information, having the advancement of science and technology in the field of high pressure as main objective. Nowadays the field has experienced an astonishing growth in an open multidisciplinary environment that rather contributed to the creation of different interdisciplinary teams of excellence, being able to face the important challenges posed by high-pressure research. Great achievements have been possible towards higher pressures, nowadays making possible experiments in the TPa range in our laboratories, the improvement and adaptation of different characterization techniques of matter under extreme conditions of pressure and temperature or the development of efficient ab initio methods with capabilities to explain and eventually predict new physical phenomena and materials design. All decisively contributed to the advance of science and understanding of nature, with high pressure as common leitmotiv. On the 50th Anniversary of the AIRAPT, this talk will is intended to commemorate the enthusiastic and encouraging work of high-pressure pioneers and to motivate young scientists to join us and continue the challenge of exploring compressed matter as a way to unveil new phenomena and materials and a better understanding of our world.

  14. High mobility group A1 enhances tumorigenicity of human cholangiocarcinoma and confers resistance to therapy

    DEFF Research Database (Denmark)

    Quintavalle, Cristina; Burmeister, Katharina; Piscuoglio, Salvatore

    2017-01-01

    High mobility group A1 (HMGA1) protein has been described to play an important role in numerous types of human carcinoma. By the modulation of several target genes HMGA1 promotes proliferation and epithelial-mesenchymal transition of tumor cells. However, its role in cholangiocarcinoma (CCA) has...

  15. Proceedings of the seventh international conference on high voltage electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, R.M.; Gronsky, R.; Westmacott, K.H. (eds.)

    1983-01-01

    Eight-four papers are arranged under the following headings: high resolution, techniques and instrumentation, radiation effects, in-situ and phase transformations, minerals and ceramics, and semiconductors and thin films. Twenty-three papers were abstracted separately for the data base; three of the remainder had previously been abstracted. (DLC)

  16. Co-expression of G2-EPSPS and glyphosate acetyltransferase GAT genes conferring high tolerance to glyphosate in soybean

    Directory of Open Access Journals (Sweden)

    Bingfu eGuo

    2015-10-01

    Full Text Available Glyphosate is a widely used non-selective herbicide with broad spectrum of weed control around the world. At present, most of the commercial glyphosate tolerant soybeans utilize glyphosate tolerant gene CP4-EPSPS or glyphosate acetyltransferase gene GAT separately. In this study, both glyphosate tolerant gene G2-EPSPS and glyphosate degraded gene GAT were co-transferred into soybean and transgenic plants showed high tolerance to glyphosate. Molecular analysis including PCR, Sothern blot, qRT-PCR and Western blot revealed that target genes have been integrated into genome and expressed effectively at both mRNA and protein levels. Furthermore, the glyphosate tolerance analysis showed that no typical symptom was observed when compared with a glyphosate tolerant line HJ06-698 derived from GR1 transgenic soybean even at four-fold labeled rate of Roundup. Chlorophyll and shikimic acid content analysis of transgenic plant also revealed that these two indexes were not significantly altered after glyphosate application. These results indicated that co-expression of G2-EPSPS and GAT conferred high tolerance to the herbicide glyphosate in soybean. Therefore, combination of tolerant and degraded genes provides a new strategy for developing glyphosate tolerant transgenic crops.

  17. Therapy with high LET Radioisotopes: Can sufficient levels of attractive Auger and alpha emitters be produced to make their use practical?

    International Nuclear Information System (INIS)

    Knapp, F.F. Jr.; Mirzadeh, S.; Stabin, M.; Brill, A.B.

    2005-01-01

    Because of localized energy deposition within a very small volume, cellular targeted therapy with high linear energy transfer (LET) Auger-electron and alpha-particle emitting radioisotopes is of great interest. While the energy deposition from alpha particles usually encompasses several cell diameters, the dose from Auger electrons is confined to a single cell. Two major challenges for broader use of Alpha and Auger emitters are the efficient and cost effective routine production of sufficient levels of these radioisotopes, and the availability of targeting molecules to which the radioisotopes can be attached for cellular delivery of sufficient levels of activity for effective therapy. Examples of several Alpha-and Auger-emitting radioisotopes of current interest are presented. Alpha- and Auger electron-emitting radioisotopes can be produced in accelerators (A) and nuclear reactors (R), and several alpha emitter congeners (i.e. thorium-229) can be obtained from uranium decay products. The challenge for reactor production, is the availability and exploitation of methods - other then the usual radiative (n,γ) production route which will provide no-carrier-added (nca) or the high specific activity radioisotopes of interest. The submitted manuscript has been authored by a contractor of the U.S. Government under contract DE-AC05-00OR22725. Accordingly, the U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for U.S. Government purposes High LET radioisotopes of current interest which are in the initial stages of development and/or which demonstrate practical use in clinical trials include several alpha-emitters, in particular bismuth-213 - and also the actinium-225 parent - astatine-211 and bismuth-212. Extensive experimental studies have been reported with Auger iododeoxyuridine (IdUR) radiolabeled with the iodine-125 emitter-labeled. However, development of production

  18. A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer.

    Science.gov (United States)

    Kelly, Karen; Kittelson, John; Franklin, Wilbur A; Kennedy, Timothy C; Klein, Catherine E; Keith, Robert L; Dempsey, Edward C; Lewis, Marina; Jackson, Mary K; Hirsch, Fred R; Bunn, Paul A; Miller, York E

    2009-05-01

    No chemoprevention strategies have been proven effective for lung cancer. We evaluated the effect of 13-cis retinoic acid (13-cis RA), with or without alpha tocopherol, as a lung cancer chemoprevention agent in a phase II randomized controlled clinical trial of adult subjects at high risk for lung cancer as defined by the presence of sputum atypia, history of smoking, and airflow obstruction, or a prior surgically cured nonsmall cell lung cancer (disease free, >3 years). Subjects were randomly assigned to receive either 13-cis RA, 13-cis RA plus alpha tocopherol (13-cis RA/alpha toco) or observation for 12 months. Outcome measures are derived from histologic evaluation of bronchial biopsy specimens obtained by bronchoscopy at baseline and follow-up. The primary outcome measure is treatment "failure" defined as histologic progression (any increase in the maximum histologic score) or failure to return for follow-up bronchoscopy. Seventy-five subjects were randomized (27/22/26 to observations/13-cis RA/13-cis RA/alpha toco); 59 completed the trial; 55 had both baseline and follow-up bronchoscopy. The risk of treatment failure was 55.6% (15 of 27) and 50% (24 of 48) in the observation and combined (13 cis RA plus 13 cis RA/alpha toco) treatment arms, respectively (odds ratio adjusted for baseline histology, 0.97; 95% confidence interval, 0.36-2.66; P = 0.95). Among subjects with complete histology data, maximum histology score in the observation arm increased by 0.37 units and by 0.03 units in the treated arms (difference adjusted for baseline, -0.18; 95% confidence interval, -1.16 to 0.81; P = 0.72). Similar (nonsignificant) results were observed for treatment effects on endobronchial proliferation as assessed by Ki-67 immunolabeling. Twelve-month treatment with 13-cis RA produced nonsignificant changes in bronchial histology, consistent with results in other trials. Agents advancing to phase III randomized trials should produce greater histologic changes. The

  19. Laser-generated ultrasound for high-precision cutting of tissue-mimicking gels (Conference Presentation)

    Science.gov (United States)

    Lee, Taehwa; Luo, Wei; Li, Qiaochu; Guo, L. Jay

    2017-03-01

    Laser-generated focused ultrasound has shown great promise in precisely treating cells and tissues by producing controlled micro-cavitation within the acoustic focal volume (30 MPa, negative pressure amplitude). By moving cavitation spots along pre-defined paths through a motorized stage, tissue-mimicking gels of different elastic moduli were cut into different shapes (rectangle, triangle, and circle), leaving behind the same shape of holes, whose sizes are less than 1 mm. The cut line width is estimated to be less than 50 um (corresponding to localized cavitation region), allowing for accurate cutting. This novel approach could open new possibility for in-vivo treatment of diseased tissues in a high-precision manner (i.e., high-precision invisible sonic scalpel).

  20. Proceedings of the topical conference on nuclear physics, high energy physics and astrophysics (NPHEAP-2010)

    International Nuclear Information System (INIS)

    Vo Van Thuan; Tran Duc Thiep; Le Hong Khiem

    2011-01-01

    There were roughly 80 scientists gathering for the NPHEAP-2010 and there 61 oral talks and posters have been presented. The audience has been introduced to the status of long term nuclear power program of Vietnam up to 2030. One of the highlights for near future activity of Vietnamese nuclear sector should be the manpower training and education for this huge master plan. Most of invited and contributed papers have devoted to both basic nuclear physics at world radioactive beams and applied nuclear instrumentation. In addition to some traditional astronomical papers, there were more contributions on advanced cosmic ray physics and related nuclear astrophysics. A few of papers on high energy and particle physics jointly showed a high interest in flavor physics at LHC, KEK and J-PARC. (NHA)

  1. The use and development of the high-temperature reactor (HTR) in China. A conference report

    International Nuclear Information System (INIS)

    Marnet, C.

    2001-01-01

    Gas-cooled graphite-moderated reactors have been under development since the early days of nuclear technology. Starting with plants in Britain and France, reactors employing this combination of coolant and moderator were used in commercial nuclear power plants in the second half of the fifties. At the same time, efforts seeking to use inert helium gas as a coolant resulted in the construction in several countries, the United States and Germany in particular, of larger nuclear power plants with higher coolant temperatures and the resultant thermodynamic advantages of high efficiencies and the option of process heat generation. Economic and political considerations led to the decommissioning of these plants. Today, research and development of high-temperature reactors are concentrated on smaller units. Work is carried out in close international cooperation, especially on project designs and newly commissioned plants in China (HTR-10), Japan (HTTR, Oarai), And South Africa (ESKOM project), but also in the USA and in Russia. (orig.) [de

  2. Adaptation and survival of plants in high stress habitats via fungal endophyte conferred stress tolerance

    Science.gov (United States)

    Rodriguez, Rusty J.; Woodward, Claire; Redman, Regina S.

    2010-01-01

    From the Arctic to the Antarctic, plants thrive in diverse habitats that impose different levels of adaptive pressures depending on the type and degree of biotic and abiotic stresses inherent to each habitat (Stevens, 1989). At any particular location, the abundance and distribution of individual plant species vary tremendously and is theorized to be based on the ability to tolerate a wide range of edaphic conditions and habitat-specific stresses (Pianka, 1966). The ability of individual plant species to thrive in diverse habitats is commonly referred to as phenotypic plasticity and is thought to involve adaptations based on changes in the plant genome (Givnish, 2002; Pan et al., 2006; Robe and Griffiths, 2000; Schurr et al., 2006). Habitats that impose high levels of abiotic stress are typically colonized with fewer plant species compared to habitats imposing low levels of stress. Moreover, high stress habitats have decreased levels of plant abundance compared to low stress habitats even though these habitats may occur in close proximity to one another (Perelman et al., 2007). This is particularly interesting because all plants are known to perceive, transmit signals, and respond to abiotic stresses such as drought, heat, and salinity (Bartels and Sunkar, 2005; Bohnert et al., 1995). Although there has been extensive research performed to determine the genetic, molecular, and physiological bases of how plants respond to and tolerate stress, the nature of plant adaptation to high stress habitats remains unresolved (Leone et al., 2003; Maggio et al., 2003; Tuberosa et al., 2003). However, recent evidence indicates that a ubiquitous aspect of plant biology (fungal symbiosis) is involved in the adaptation and survival of at least some plants in high stress habitats (Rodriguez et al., 2008).

  3. Regime dependence of photo-darkening-induced modal degradation in high power fiber amplifier (Conference Presentation)

    Science.gov (United States)

    Boullet, Johan; Vincont, Cyril; Jolly, Alain; Pierre, Christophe

    2017-03-01

    Thermally induced transverse modal instabilities (TMI) have attracted these five years an intense research efforts of the entire fiber laser development community, as it represents the current most limiting effect of further power scaling of high power fiber laser. Anyway, since 2014, a few publications point out a new limiting thermal effect: fiber modal degradation (FMD). It is characterized by a power rollover and simultaneous increase of the cladding light at an average power far from the TMI threshold together with a degraded beam which does not exhibit temporal fluctuations, which is one of the main characteristic of TMI. We report here on the first systemic experimental study of FMD in a high power photonic crystal fiber. We put a particular emphasis on the dependence of its average power threshold on the regime of operation. We experimentally demonstrate that this dependence is intrinsically linked to regime-dependent PD-saturated losses, which are nearly three times higher in CW regime than in short pulse picosecond regime. We make the hypothesis that the existence of these different PD equilibrium states between CW regime and picosecond QCW pulsed regime is due to a partial photo-bleaching of color centers in picosecond regime thanks to a higher probability of multi-photon process induced photobleaching (PB) at high peak power. This hypothesis is corroborated by the demonstration of the reversibility of the FMD induced in CW regime by simply switching the seed CW 1064 nm light by a short pulse, picosecond oscillator.

  4. Conference summaries

    International Nuclear Information System (INIS)

    1988-01-01

    This volume contains conference summaries of the 28. annual conference of the Canadian Nuclear Association, and the 9. annual conference of the Canadian Nuclear Society. Topics of discussion include: power reactors; fuel cycles; nuclear power and public understanding; future trends; applications of nuclear technology; CANDU reactors; operational enhancements; design of small reactors; accident behaviour in fuel channels; fuel storage and waste management; reactor commissioning/decommissioning; nuclear safety experiments and modelling; the next generation reactors; advances in nuclear engineering education in Canada; safety of small reactors; current position and improvements of fuel channels; current issues in nuclear safety; and radiation applications - medical and industrial

  5. Sparse trees and shrubs confers a high biodiversity to pastures: Case study on spiders from Transylvania.

    Science.gov (United States)

    Gallé, Róbert; Urák, István; Nikolett, Gallé-Szpisjak; Hartel, Tibor

    2017-01-01

    The integration of food production and biodiversity conservation represents a key challenge for sustainability. Several studies suggest that even small structural elements in the landscape can make a substantial contribution to the overall biodiversity value of the agricultural landscapes. Pastures can have high biodiversity potential. However, their intensive and monofunctional use typically erodes its natural capital, including biodiversity. Here we address the ecological value of fine scale structural elements represented by sparsely scattered trees and shrubs for the spider communities in a moderately intensively grazed pasture in Transylvania, Eastern Europe. The pasture was grazed with sheep, cattle and buffalo (ca 1 Livestock Unit ha-1) and no chemical fertilizers were applied. Sampling sites covered the open pasture as well as the existing fine-scale heterogeneity created by scattered trees and shrub. 40 sampling locations each being represented by three 1 m2 quadrats were situated in a stratified design while assuring spatial independency of sampling locations. We identified 140 species of spiders, out of which 18 were red listed and four were new for the Romanian fauna. Spider species assemblages of open pasture, scattered trees, trees and shrubs and the forest edge were statistically distinct. Our study shows that sparsely scattered mature woody vegetation and shrubs substantially increases the ecological value of managed pastures. The structural complexity provided by scattered trees and shrubs makes possible the co-occurrence of high spider diversity with a moderately high intensity grazing possible in this wood-pasture. Our results are in line with recent empirical research showing that sparse trees and shrubs increases the biodiversity potential of pastures managed for commodity production.

  6. MEMS microphone innovations towards high signal to noise ratios (Conference Presentation) (Plenary Presentation)

    Science.gov (United States)

    Dehé, Alfons

    2017-06-01

    After decades of research and more than ten years of successful production in very high volumes Silicon MEMS microphones are mature and unbeatable in form factor and robustness. Audio applications such as video, noise cancellation and speech recognition are key differentiators in smart phones. Microphones with low self-noise enable those functions. Backplate-free microphones enter the signal to noise ratios above 70dB(A). This talk will describe state of the art MEMS technology of Infineon Technologies. An outlook on future technologies such as the comb sensor microphone will be given.

  7. High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor

    Science.gov (United States)

    Pichlo, Magdalena; Bungert-Plümke, Stefanie; Weyand, Ingo; Seifert, Reinhard; Bönigk, Wolfgang; Strünker, Timo; Kashikar, Nachiket Dilip; Goodwin, Normann; Müller, Astrid; Körschen, Heinz G.; Collienne, Ursel; Pelzer, Patric; Van, Qui; Enderlein, Jörg; Klemm, Clementine; Krause, Eberhard; Trötschel, Christian; Poetsch, Ansgar; Kremmer, Elisabeth

    2014-01-01

    Guanylyl cyclases (GCs), which synthesize the messenger cyclic guanosine 3′,5′-monophosphate, control several sensory functions, such as phototransduction, chemosensation, and thermosensation, in many species from worms to mammals. The GC chemoreceptor in sea urchin sperm can decode chemoattractant concentrations with single-molecule sensitivity. The molecular and cellular underpinnings of such ultrasensitivity are not known for any eukaryotic chemoreceptor. In this paper, we show that an exquisitely high density of 3 × 105 GC chemoreceptors and subnanomolar ligand affinity provide a high ligand-capture efficacy and render sperm perfect absorbers. The GC activity is terminated within 150 ms by dephosphorylation steps of the receptor, which provides a means for precise control of the GC lifetime and which reduces “molecule noise.” Compared with other ultrasensitive sensory systems, the 10-fold signal amplification by the GC receptor is surprisingly low. The hallmarks of this signaling mechanism provide a blueprint for chemical sensing in small compartments, such as olfactory cilia, insect antennae, or even synaptic boutons. PMID:25135936

  8. High-spatial-resolution mapping of the oxygen concentration in cortical tissue (Conference Presentation)

    Science.gov (United States)

    Jaswal, Rajeshwer S.; Yaseen, Mohammad A.; Fu, Buyin; Boas, David A.; Sakadžic, Sava

    2016-03-01

    Due to a lack of imaging tools for high-resolution imaging of cortical tissue oxygenation, the detailed maps of the oxygen partial pressure (PO2) around arterioles, venules, and capillaries remain largely unknown. Therefore, we have limited knowledge about the mechanisms that secure sufficient oxygen delivery in microvascular domains during brain activation, and provide some metabolic reserve capacity in diseases that affect either microvascular networks or the regulation of cerebral blood flow (CBF). To address this challenge, we applied a Two-Photon PO2 Microscopy to map PO2 at different depths in mice cortices. Measurements were performed through the cranial window in the anesthetized healthy mice as well as in the mouse models of microvascular dysfunctions. In addition, microvascular morphology was recorded by the two-photon microscopy at the end of each experiment and subsequently segmented. Co-registration of the PO2 measurements and exact microvascular morphology enabled quantification of the tissue PO2 dependence on distance from the arterioles, capillaries, and venules at various depths. Our measurements reveal significant spatial heterogeneity of the cortical tissue PO2 distribution that is dominated by the high oxygenation in periarteriolar spaces. In cases of impaired oxygen delivery due to microvascular dysfunction, significant reduction in tissue oxygenation away from the arterioles was observed. These tissue domains may be the initial sites of cortical injury that can further exacerbate the progression of the disease.

  9. Biomimetic hairy surfaces as superhydrophobic highly transmissive films for optical applications (Conference Presentation)

    Science.gov (United States)

    Vuellers, Felix; Gomard, Guillaume; Preinfalk, Jan B.; Klampaftis, Efthymios; Worgull, Matthias; Richards, Bryce S.; Hölscher, Hendrik; Kavalenka, Maryna N.

    2017-02-01

    Combining high optical transmission, water-repellency and self-cleaning is of great interest for optoelectronic devices operating in outdoor conditions, such as photovoltaics where shading can significantly reduce the power output. The surface of water plant Pistia stratiotes combines these functionalities through a dense layer of transparent microhairs. It renders the surface superhydrophobic without affecting absorption of sunlight necessary for photosynthesis. Inspired by this surface, we fabricated a superhydrophobic flexible thin nanofur film made from optical grade polycarbonate using a scalable combination of hot embossing and hot pulling techniques. During fabrication, heated sandblasted steel plates locally elongate softened polymer, thus covering its surface in microcavities surrounded by high aspect ratio micro- and nanohairs. The superhydrophobic nanofur exhibits contact angles of (166+/-6°), low sliding angles (drops below 4% when coated on a polymeric substrate, which can enhance light extraction in organic light emitting diodes (OLEDs). We report an increase of more than 10% in luminous efficacy for a nanofur coated OLED compared to a bare device. Finally, the nanofur film can be used for enhancing the incoupling of light to solar cells, while additionally providing self-cleaning properties. Optical coupling of the nanofur to a multi-crystalline silicon solar cell results in a 5.8% gain in photocurrent compared to a bare device under normal incidence.

  10. Papers presented at the Tenth Topical Conference on High-Temperature Plasma Diagnostics

    International Nuclear Information System (INIS)

    1994-01-01

    This report contains papers on the following topics: Effects of limited spatial resolution on fluctuation measurements; vertical viewing of electron-cyclotron radiation in Text-U; measurement of temperature fluctuations from electron-cyclotron emission; a varying cross section magnetic coil diagnostic used in digital feedback control of plasma position in Text-Upgrade; high-sensitivity, high resolution measurements of radiated power on Text-U; wave launching as a diagnostic tool to investigate plasma turbulence; edge parameters from an energy analyzer and particle transport on Text-U; initial results from a charge exchange q-Diagnostic on Text-U; a method for neutral spectra analysis taking ripple-trapped particle losses into account; application of a three sample volume S(k,ω ) estimate to optical measurements of turbulence on Text; initial operation of the 2D Firsis on Text-Upgrade; horizontal-view interferometer on Text-Upgrade; plasma potential measurements on Text-Upgrade with A 2 MeV heavy ion beam; fluctuation measurements using the 2 MeV heavy ion beam probe on Text-U; the time domain triple probe method; a phase contrast imaging system for Text-U; and development of rugged corner cube detectors for the Text-U-Fir interferometer. These papers have been placed on the database elsewhere

  11. "High/Scope Supporting the Child, the Family, the Community": A Report of the Proceedings of the High/Scope Ireland Third Annual Conference, 12th October 2004, Newry, Northern Ireland

    Science.gov (United States)

    Peyton, Lynne

    2005-01-01

    The third annual High/Scope Ireland Conference provided a forum for speakers workshop leaders and delegates from across Ireland, the UK, USA, Europe and South Africa to share their experiences of High/Scope in action. Research demonstrates that long term benefits for High/Scope participants include increased literacy rates, school success and…

  12. Combined adjuvant radiation and interferon-alpha 2B therapy in high-risk melanoma patients: the potential for increased radiation toxicity

    International Nuclear Information System (INIS)

    Hazard, Lisa J.; Sause, William T.; Noyes, R. Dirk

    2002-01-01

    Purpose: Surgically resected melanoma patients with high-risk features commonly receive adjuvant therapy with interferon-alpha 2b combined with radiation therapy; the purpose of our study was to evaluate the potential enhancement of radiation toxicity by interferon. Methods and Materials: Patients at LDS Hospital and the University of Utah Medical Center in Salt Lake City treated with interferon during radiotherapy or within 1 month of its completion were retrospectively identified, and their charts were reviewed. If possible, the patients were asked to return to the LDS Hospital radiation therapy department for follow-up. Results: Five of 10 patients receiving interferon-alpha 2b therapy during radiation therapy or within 1 month of its completion experienced severe subacute/late complications of therapy. Severe subacute/late complications included two patients with peripheral neuropathy, one patient with radiation necrosis in the brain, and two patients with radiation necrosis in the s.c. tissue. One patient with peripheral neuropathy and one patient with radiation necrosis also developed lymphedema. Conclusions: In vitro studies have identified a radiosensitizing effect by interferon-alpha on certain cell lines, which suggests the possibility that patients treated with interferon and radiation therapy may experience more severe radiation toxicities. We have observed severe subacute/late complications in five of 10 patients treated with interferon-alpha 2b during radiation therapy or within 1 month of its completion. Although an observational study of 10 patients lacks the statistic power to reach conclusions regarding the safety and complication rates of combined interferon and radiation therapy, it is sufficient to raise concerns and suggest the need for prospective studies

  13. Influence of High Aspect Ratio Vessel Cell Culture on TNF-Alpha, Insulin Secretion and Glucose Homeostasis in Pancreatic Islets of Langerhans from Wistar Furth Rats

    Science.gov (United States)

    Tobin, Brian W.a; Leeper-Woodford, Sandra K.

    1999-01-01

    The present studies were carried out to determine the influence of a ground based microgravity paradigm, utilizing the High Aspect Ratio Vessel (HARV) cell culture upon lipopolysaccharide (LPS) stimulated tumor necrosis factor alpha (TNF-alpha) production of pancreatic islets of Langerhans. An additional aim was to elucidate alterations in insulin secretion and glucose utilization using the HARV low shear, gravity averaged vector, cell culture technique. Islets were isolated (1726 +/- 117, 150 micron islet equivalent units) from Wistar Furth rats and assigned to four treatment groups: 1) HARV, 2) HARV plus LPS, 3) static culture, 4) static culture plus LPS. Following 48 hours of culture, insulin concentration was increased in both HARV and static cultures (palpha (L929 cytotoxicity assay) and was measured at selected time points for 48 hours. TNF-alpha was significantly increased in LPS-induced HARV and static cultures, yet the increase was more pronounced in the static culture group (palpha is associated with a decreased insulin secretion is intriguing, both as it relates to in-flight investigations, and as it may provide insight into the pathophysiology of Type I and Type 11 diabetes. Glucose concentration in islet medium was lesser throughout the experiment in static cultures, suggesting a decreased reliance upon glucose as a metabolic substrate in the islets cultured in HARVS. In conclusion, the present studies demonstrate alterations in LPS induced TNF-alpha production of pancreatic islets of Langerhans, favoring a lesser TNF production in the microgravity HARV paradigm. Additionally, alterations in fuel homeostasis may be promulgated by HARV culture. The clinical and physiological significance of these observations remains to be determined.

  14. Cloud detection method for Chinese moderate high resolution satellite imagery (Conference Presentation)

    Science.gov (United States)

    Zhong, Bo; Chen, Wuhan; Wu, Shanlong; Liu, Qinhuo

    2016-10-01

    Cloud detection of satellite imagery is very important for quantitative remote sensing research and remote sensing applications. However, many satellite sensors don't have enough bands for a quick, accurate, and simple detection of clouds. Particularly, the newly launched moderate to high spatial resolution satellite sensors of China, such as the charge-coupled device on-board the Chinese Huan Jing 1 (HJ-1/CCD) and the wide field of view (WFV) sensor on-board the Gao Fen 1 (GF-1), only have four available bands including blue, green, red, and near infrared bands, which are far from the requirements of most could detection methods. In order to solve this problem, an improved and automated cloud detection method for Chinese satellite sensors called OCM (Object oriented Cloud and cloud-shadow Matching method) is presented in this paper. It firstly modified the Automatic Cloud Cover Assessment (ACCA) method, which was developed for Landsat-7 data, to get an initial cloud map. The modified ACCA method is mainly based on threshold and different threshold setting produces different cloud map. Subsequently, a strict threshold is used to produce a cloud map with high confidence and large amount of cloud omission and a loose threshold is used to produce a cloud map with low confidence and large amount of commission. Secondly, a corresponding cloud-shadow map is also produced using the threshold of near-infrared band. Thirdly, the cloud maps and cloud-shadow map are transferred to cloud objects and cloud-shadow objects. Cloud and cloud-shadow are usually in pairs; consequently, the final cloud and cloud-shadow maps are made based on the relationship between cloud and cloud-shadow objects. OCM method was tested using almost 200 HJ-1/CCD images across China and the overall accuracy of cloud detection is close to 90%.

  15. 13th TOPICAL CONFERENCE ON HIGH TEMPERATURE PLASMA DIAGNOSTICS SCIENTIFIC PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    C. BARNES

    2000-07-01

    Electron cyclotron emission (ECE) has been employed as a standard electron temperature profile diagnostic on many tokamaks and stellarators, but most magnetically confined plasma devices cannot take advantage of standard ECE diagnostics to measure temperature. They are either overdense, operating at high density relative to the magnetic field (e.g. {omega}{sub pe} >> {Omega}{sub ce} in a spherical torus) or they have insufficient density and temperature to reach the blackbody condition ({tau} > 2). Electron Bernstein waves (EBWs) are electrostatic waves which can propagate in overdense plasmas and have a high optical thickness at the electron cyclotron resonance layers, as a result of their large K{sub i}. This talk reports on measurements of EBW emission on the CDX-U spherical torus, where B{sub 0} {approx} 2 kG, {approx} 10{sup 13} cm{sup -3} and T{sub e} {approx} 10 - 200 eV. Results will be presented for both direct detection of EBWs and for mode-converted EBW emission. The EBW emission was absolutely calibrated and compared to the electron temperature profile measured by a multi-point Thomson scattering diagnostic. Depending on the plasma conditions, the mode-converted EBW radiation temperature was found to be {le} T{sub e} and the emission source was determined to be radially localized at the electron cyclotron resonance layer. A Langmuir triple probe was employed to measure changes in edge density profile in the vicinity of the upper hybrid resonance where the mode conversion of the EBWs is expected to occur. Changes in the mode conversion efficiency may explain the observation of mode-converted EBW radiation temperatures below T{sub e}. Initial results suggest EBW emission and EBW heating are viable concepts for plasmas where {omega}{sub pe} >> {Omega}{sub ce}.

  16. Accessory genes confer a high replication rate to virulent feline immunodeficiency virus.

    Science.gov (United States)

    Troyer, Ryan M; Thompson, Jesse; Elder, John H; VandeWoude, Sue

    2013-07-01

    Feline immunodeficiency virus (FIV) is a lentivirus that causes AIDS in domestic cats, similar to human immunodeficiency virus (HIV)/AIDS in humans. The FIV accessory protein Vif abrogates the inhibition of infection by cat APOBEC3 restriction factors. FIV also encodes a multifunctional OrfA accessory protein that has characteristics similar to HIV Tat, Vpu, Vpr, and Nef. To examine the role of vif and orfA accessory genes in FIV replication and pathogenicity, we generated chimeras between two FIV molecular clones with divergent disease potentials: a highly pathogenic isolate that replicates rapidly in vitro and is associated with significant immunopathology in vivo, FIV-C36 (referred to here as high-virulence FIV [HV-FIV]), and a less-pathogenic strain, FIV-PPR (referred to here as low-virulence FIV [LV-FIV]). Using PCR-driven overlap extension, we produced viruses in which vif, orfA, or both genes from virulent HV-FIV replaced equivalent genes in LV-FIV. The generation of these chimeras is more straightforward in FIV than in primate lentiviruses, since FIV accessory gene open reading frames have very little overlap with other genes. All three chimeric viruses exhibited increased replication kinetics in vitro compared to the replication kinetics of LV-FIV. Chimeras containing HV-Vif or Vif/OrfA had replication rates equivalent to those of the virulent HV-FIV parental virus. Furthermore, small interfering RNA knockdown of feline APOBEC3 genes resulted in equalization of replication rates between LV-FIV and LV-FIV encoding HV-FIV Vif. These findings demonstrate that Vif-APOBEC interactions play a key role in controlling the replication and pathogenicity of this immunodeficiency-inducing virus in its native host species and that accessory genes act as mediators of lentiviral strain-specific virulence.

  17. Overexpression of cotton RAV1 gene in Arabidopsis confers transgenic plants high salinity and drought sensitivity.

    Science.gov (United States)

    Li, Xiao-Jie; Li, Mo; Zhou, Ying; Hu, Shan; Hu, Rong; Chen, Yun; Li, Xue-Bao

    2015-01-01

    RAV (related to ABI3/VP1) protein containing an AP2 domain in the N-terminal region and a B3 domain in the C-terminal region, which belongs to AP2 transcription factor family, is unique in higher plants. In this study, a gene (GhRAV1) encoding a RAV protein of 357 amino acids was identified in cotton (Gossypium hirsutum). Transient expression analysis of the eGFP:GhRAV1 fusion genes in tobacco (Nicotiana tabacum) epidermal cells revealed that GhRAV1 protein was localized in the cell nucleus. Quantitative RT-PCR analysis indicated that expression of GhRAV1 in cotton is induced by abscisic acid (ABA), NaCl and polyethylene glycol (PEG). Overexpression of GhRAV1 in Arabidopsis resulted in plant sensitive to ABA, NaCl and PEG. With abscisic acid (ABA) treatment, seed germination and green seedling rates of the GhRAV1 transgenic plants were remarkably lower than those of wild type. In the presence of NaCl, the seed germination and seedling growth of the GhRAV1 transgenic lines were inhibited greater than those of wild type. And chlorophyll content and maximum photochemical efficiency of the transgenic plants were significantly lower than those of wild type. Under drought stress, the GhRAV1 transgenic plants displayed more severe wilting than wild type. Furthermore, expressions of the stress-related genes were altered in the GhRAV1 transgenic Arabidopsis plants under high salinity and drought stresses. Collectively, our data suggested that GhRAV1 may be involved in response to high salinity and drought stresses through regulating expressions of the stress-related genes during cotton development.

  18. Implementation of machine learning for high-volume manufacturing metrology challenges (Conference Presentation)

    Science.gov (United States)

    Timoney, Padraig; Kagalwala, Taher; Reis, Edward; Lazkani, Houssam; Hurley, Jonathan; Liu, Haibo; Kang, Charles; Isbester, Paul; Yellai, Naren; Shifrin, Michael; Etzioni, Yoav

    2018-03-01

    In recent years, the combination of device scaling, complex 3D device architecture and tightening process tolerances have strained the capabilities of optical metrology tools to meet process needs. Two main categories of approaches have been taken to address the evolving process needs. In the first category, new hardware configurations are developed to provide more spectral sensitivity. Most of this category of work will enable next generation optical metrology tools to try to maintain pace with next generation process needs. In the second category, new innovative algorithms have been pursued to increase the value of the existing measurement signal. These algorithms aim to boost sensitivity to the measurement parameter of interest, while reducing the impact of other factors that contribute to signal variability but are not influenced by the process of interest. This paper will evaluate the suitability of machine learning to address high volume manufacturing metrology requirements in both front end of line (FEOL) and back end of line (BEOL) sectors from advanced technology nodes. In the FEOL sector, initial feasibility has been demonstrated to predict the fin CD values from an inline measurement using machine learning. In this study, OCD spectra were acquired after an etch process that occurs earlier in the process flow than where the inline CD is measured. The fin hard mask etch process is known to impact the downstream inline CD value. Figure 1 shows the correlation of predicted CD vs downstream inline CD measurement obtained after the training of the machine learning algorithm. For BEOL, machine learning is shown to provide an additional source of information in prediction of electrical resistance from structures that are not compatible for direct copper height measurement. Figure 2 compares the trench height correlation to electrical resistance (Rs) and the correlation of predicted Rs to the e-test Rs value for a far back end of line (FBEOL) metallization level

  19. Humic Acid Confers HIGH-AFFINITY K+ TRANSPORTER 1-Mediated Salinity Stress Tolerance in Arabidopsis.

    Science.gov (United States)

    Khaleda, Laila; Park, Hee Jin; Yun, Dae-Jin; Jeon, Jong-Rok; Kim, Min Gab; Cha, Joon-Yung; Kim, Woe-Yeon

    2017-12-31

    Excessive salt disrupts intracellular ion homeostasis and inhibits plant growth, which poses a serious threat to global food security. Plants have adapted various strategies to survive in unfavorable saline soil conditions. Here, we show that humic acid (HA) is a good soil amendment that can be used to help overcome salinity stress because it markedly reduces the adverse effects of salinity on Arabidopsis thaliana seedlings. To identify the molecular mechanisms of HA-induced salt stress tolerance in Arabidopsis, we examined possible roles of a sodium influx transporter HIGH-AFFINITY K+ TRANSPORTER 1 (HKT1). Salt-induced root growth inhibition in HKT1 overexpressor transgenic plants (HKT1-OX) was rescued by application of HA, but not in wild-type and other plants. Moreover, salt-induced degradation of HKT1 protein was blocked by HA treatment. In addition, the application of HA to HKT1-OX seedlings led to increased distribution of Na+ in roots up to the elongation zone and caused the reabsorption of Na+ by xylem and parenchyma cells. Both the influx of the secondary messenger calcium and its cytosolic release appear to function in the destabilization of HKT1 protein under salt stress. Taken together, these results suggest that HA could be applied to the field to enhance plant growth and salt stress tolerance via post-transcriptional control of the HKT1 transporter gene under saline conditions.

  20. High-speed imaging and evolution dynamics of laser induced deposition of conductive inks (Conference Presentation)

    Science.gov (United States)

    Makrygianni, Marina; Papazoglou, Symeon; Zacharatos, Filimonas; Chatzandroulis, Stavros; Zergioti, Ioanna

    2017-02-01

    During the last decade there is an ever-increasing interest for the study of laser processes dynamics and specifically of the Laser Induced Forward Transfer (LIFT) technique, since the evolution of the phenomena under investigation may provide real time metrology in terms of jet velocity, adjacent jet interaction and impact pressure. The study of such effects leads to a more thorough understanding of the deposition process, hence to an improved printing outcome and in these frames, this work presents a study on the dynamics of LIFT for conductive nanoparticles inks using high-speed imaging approaches. Moreover, in this study, we investigated the printing regimes and the printing quality during the transfer of copper (Cu) nanoink, which is a metallic nanoink usually employed in interconnect formation as well as the printing of silver nanowires, which provide transparency and may be used in applications where transparent electrodes are needed as in photovoltaics, batteries, etc. Furthermore, we demonstrate the fabrication of an all laser printed resistive chemical sensor device that combines Ag nanoparticles ink and graphene oxide, for the detection of humidity fabricated on a flexible polyimide substrate. The sensor device architecture was able to host multiple pairs of electrodes, where Ag nanoink or nanopaste were laser printed, to form the electrodes as well as the electrical interconnections between the operating device and the printed circuit board. Performance evaluation was conducted upon flow of different concentrations of humidity vapors to the sensor, and good response (500 ppm limit of detection) with reproducible operation was observed.

  1. News Quantum physics: German Physical Society spring meeting Journal access: American Physical Society's online journals will be available for free in all US high schools Award: High-school physics teacher receives American award for excellence Teacher training: Fobinet offers coordination of teacher-training activities Astronomy: Astronomy fans see stars at Astrofest Conference: Delegates enjoy the workshops and activities at CPD conference Forthcoming events

    Science.gov (United States)

    2011-05-01

    Quantum physics: German Physical Society spring meeting Journal access: American Physical Society's online journals will be available for free in all US high schools Award: High-school physics teacher receives American award for excellence Teacher training: Fobinet offers coordination of teacher-training activities Astronomy: Astronomy fans see stars at Astrofest Conference: Delegates enjoy the workshops and activities at CPD conference Forthcoming events

  2. IncA/C plasmids conferring high azithromycin resistance in vibrio cholerae.

    Science.gov (United States)

    Wang, Ruibai; Liu, Haican; Zhao, Xiuqin; Li, Jie; Wan, Kanglin

    2018-01-01

    Azithromycin (AZM) is a clinically important antibiotic against Vibrio cholerae, especially for inhibiting V. cholerae colonisation of the intestine and for the treatment of severe cholera in children and pregnant women. An IncA/C plasmid was isolated from two high minimum inhibitory concentration (MIC) AZM-resistant V. cholerae strains of the two mainly pathogenic serogroups (O1 and O139) isolated in China. In the 172 predicted open reading frames (ORFs), 16 genes were related to antibiotic resistance, of which 5 were well-defined genes associated with macrolide resistance. The five macrolide resistance genes distributed in two clusters, mphR-mrx-mph(K) and mel-mph2, flanked by insertion sequence elements and involving two kinds of resistance mechanism. Deletion of the complete region of the two clusters deceased the AZM MIC from ≥64 µg/mL to ≤0.5 µg/mL. This IncA/C plasmid shows great ability to accumulate antibiotic resistance genes. In addition to 11 resistance genes to other antibiotics, 5 macrolide resistance genes with different function were gathered repeatedly through transposition on one plasmid. This genotype could not be simply explained by antibiotic stress applied on the host from the environment or treatment. These phosphorylases and transmembrane transporters might be involved in the transport and metabolism of other non-antibiotic substances, enabling this kind of plasmid to propagate better in the host. Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

  3. High modulation bandwidth of a light-emitting diode with surface plasmon coupling (Conference Presentation)

    Science.gov (United States)

    Lin, Chun-Han; Tu, Charng-Gan; Yao, Yu-Feng; Chen, Sheng-Hung; Su, Chia-Ying; Chen, Hao-Tsung; Kiang, Yean-Woei; Yang, Chih-Chung

    2017-02-01

    Besides lighting, LEDs can be used for indoor data transmission. Therefore, a large modulation bandwidth becomes an important target in the development of visible LED. In this regard, enhancing the radiative recombination rate of carriers in the quantum wells of an LED is a useful method since the modulation bandwidth of an LED is related to the carrier decay rate besides the device RC time constant To increase the carrier decay rate in an LED without sacrificing its output power, the technique of surface plasmon (SP) coupling in an LED is useful. In this paper, the increases of modulation bandwidth by reducing mesa size, decreasing active layer thickness, and inducing SP coupling in blue- and green-emitting LEDs are illustrated. The results are demonstrated by comparing three different LED surface structures, including bare p-type surface, GaZnO current spreading layer, and Ag nanoparticles (NPs) for inducing SP coupling. In a single-quantum-well, blue-emitting LED with a circular mesa of 10 microns in radius, SP coupling results in a modulation bandwidth of 528.8 MHz, which is believed to be the record-high level. A smaller RC time constant can lead to a higher modulation bandwidth. However, when the RC time constant is smaller than 0.2 ns, its effect on modulation bandwidth saturates. The dependencies of modulation bandwidth on injected current density and carrier decay time confirm that the modulation bandwidth is essentially inversely proportional to a time constant, which is inversely proportional to the square-root of carrier decay rate and injected current density.

  4. Dietary flavonoid fisetin increases abundance of high-molecular-mass hyaluronan conferring resistance to prostate oncogenesis.

    Science.gov (United States)

    Lall, Rahul K; Syed, Deeba N; Khan, Mohammad Imran; Adhami, Vaqar M; Gong, Yuansheng; Lucey, John A; Mukhtar, Hasan

    2016-09-01

    We and others have shown previously that fisetin, a plant flavonoid, has therapeutic potential against many cancer types. Here, we examined the probable mechanism of its action in prostate cancer (PCa) using a global metabolomics approach. HPLC-ESI-MS analysis of tumor xenografts from fisetin-treated animals identified several metabolic targets with hyaluronan (HA) as the most affected. Efficacy of fisetin on HA was then evaluated in vitro and also in vivo in the transgenic TRAMP mouse model of PCa. Size exclusion chromatography-multiangle laser light scattering (SEC-MALS) was performed to analyze the molar mass (Mw) distribution of HA. Fisetin treatment downregulated intracellular and secreted HA levels both in vitro and in vivo Fisetin inhibited HA synthesis and degradation enzymes, which led to cessation of HA synthesis and also repressed the degradation of the available high-molecular-mass (HMM)-HA. SEC-MALS analysis of intact HA fragment size revealed that cells and animals have more abundance of HMM-HA and less of low-molecular-mass (LMM)-HA upon fisetin treatment. Elevated HA levels have been shown to be associated with disease progression in certain cancer types. Biological responses triggered by HA mainly depend on the HA polymer length where HMM-HA represses mitogenic signaling and has anti-inflammatory properties whereas LMM-HA promotes proliferation and inflammation. Similarly, Mw analysis of secreted HA fragment size revealed less HMM-HA is secreted that allowed more HMM-HA to be retained within the cells and tissues. Our findings establish that fisetin is an effective, non-toxic, potent HA synthesis inhibitor, which increases abundance of antiangiogenic HMM-HA and could be used for the management of PCa. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  5. Case Study - Alpha

    Directory of Open Access Journals (Sweden)

    Stephen Leybourne

    2016-11-01

    Full Text Available This case study was developed from an actual scenario by Dr. Steve Leybourne of Boston University.  The case documents the historical evolution of an organization, and has been used successfully in courses dealing with organizational and cultural change, and the utilization of ‘soft skills’ in project-based management. This is a short case, ideal for classroom use and discussion.  The issues are easily accessible to students, and there is a single wide ranging question that allows for the inclusion of many issues surrounding strategic decision-making, and behavioural and cultural change. Alpha was one of the earlier companies in the USA to invest in large, edge-of-town superstores, with plentiful free vehicle parking, selling food and related household products. Alpha was created in the 1950s as a subsidiary of a major publicly quoted retail group.  It started business by opening a string of very large discount stores in converted industrial and warehouse premises in the south of the United States. In the early days shoppers were offered a limited range of very competitively priced products. When Alpha went public in 1981 it was the fourth largest food retailer in the US, selling an ever-widening range of food and non-food products.  Its success continued to be based on high volume, low margins and good value for money, under the slogan of ‘Alpha Price.’

  6. Report of a Technical Meeting on ''Alpha emitting radionuclides and radiopharmaceuticals for therapy''

    International Nuclear Information System (INIS)

    2013-01-01

    Considering the high potential of α-emitters for future development of radionuclide therapy, the International Atomic Energy Agency (IAEA) organized a Technical Meeting on ‘Alpha Emitting Radionuclides and Radiopharmaceuticals for Therapy’, from June 24 to 28, 2013, at IAEA Headquarters in Vienna with the purpose of gathering eminent Experts in the field and discuss with them the status and future perspectives of the field. Sixteen Experts and two External Observers from ten different countries, and four IAEA Technical Officers attended this meeting. Outstanding lectures have been presented covering all relevant aspects of α-therapy, which were followed by extensive discussions and analysis. Selected arguments encompassed production methods and availability of alpha-emitting radionuclides, labelling chemistry of alpha-emittting radioelements, design and development of target-specific radiopharmaceuticals, physical principles of alpha-particle dosimetry and advanced dosimetric models, biological effects of alpha radiation at the cellular level, on-going preclinical and clinical studies with new radiopharmaceuticals, results of clinical trials on the use of radium-223 chloride solutions for the treatment of metastatic bone cancer. The broad scientific background of invited components of the Experts’ panel conferred a strong interdisciplinary trait to the overall discussion and stimulated a critical analysis of this emerging unexplored field. Results of this comprehensive overview on alpha therapy, including recommendations to the Agency on suitable initiatives that may help to promote and spread the knowledge to Members States on this emerging therapeutic modality, are summarized in the present Report

  7. Newly Identified Wild Rice Accessions Conferring High Salt Tolerance Might Use a Tissue Tolerance Mechanism in Leaf

    Science.gov (United States)

    Prusty, Manas R.; Kim, Sung-Ryul; Vinarao, Ricky; Entila, Frederickson; Egdane, James; Diaz, Maria G. Q.; Jena, Kshirod K.

    2018-01-01

    Cultivated rice (Oryza sativa L.) is very sensitive to salt stress. So far a few rice landraces have been identified as a source of salt tolerance and utilized in rice improvement. These tolerant lines primarily use Na+ exclusion mechanism in root which removes Na+ from the xylem stream by membrane Na+ and K+ transporters, and resulted in low Na+ accumulation in shoot. Identification of a new donor source conferring high salt tolerance is imperative. Wild relatives of rice having wide genetic diversity are regarded as a potential source for crop improvement. However, they have been less exploited against salt stress. Here, we simultaneously evaluated all 22 wild Oryza species along with the cultivated tolerant lines including Pokkali, Nona Bokra, and FL478, and sensitive check varieties under high salinity (240 mM NaCl). Based on the visual salt injury score, three species (O. alta, O. latifolia, and O. coarctata) and four species (O. rhizomatis, O. eichingeri, O. minuta, and O. grandiglumis) showed higher and similar level of tolerance compared to the tolerant checks, respectively. All three CCDD genome species exhibited salt tolerance, suggesting that the CCDD genome might possess the common genetic factors for salt tolerance. Physiological and biochemical experiments were conducted using the newly isolated tolerant species together with checks under 180 mM NaCl. Interestingly, all wild species showed high Na+ concentration in shoot and low concentration in root unlike the tolerant checks. In addition, the wild-tolerant accessions showed a tendency of a high tissue tolerance in leaf, low malondialdehyde level in shoot, and high retention of chlorophyll in the young leaves. These results suggest that the wild species employ tissue tolerance mechanism to manage salt stress. Gene expression analyses of the key salt tolerance-related genes suggested that high Na+ in leaf of wild species might be affected by OsHKT1;4-mediated Na+ exclusion in leaf and the following Na

  8. Measurement of total alpha activity of neptunium, plutonium, and americium in highly radioactive Hanford waste by iron hydroxide precipitation and 2-heptanone solvent extraction

    International Nuclear Information System (INIS)

    Maiti, T.C.; Kaye, J.H.

    1992-06-01

    An improved method has been developed to concentrate the major alpha-emitting actinide elements neptunium, plutonium, and americium from samples with high salt content such as those resulting from efforts to characterize Hanford storage tank waste. Actinide elements are concentrated by coprecipitation of their hydroxides using iron carrier. The iron is removed by extraction from 8M HCI with 2-heptanone. The actinide elements remain in the aqueous phase free from salts, iron, and long-lived fission products. Recoveries averaged 98 percent

  9. F-18 High Alpha Research Vehicle (HARV) parameter identification flight test maneuvers for optimal input design validation and lateral control effectiveness

    Science.gov (United States)

    Morelli, Eugene A.

    1995-01-01

    Flight test maneuvers are specified for the F-18 High Alpha Research Vehicle (HARV). The maneuvers were designed for open loop parameter identification purposes, specifically for optimal input design validation at 5 degrees angle of attack, identification of individual strake effectiveness at 40 and 50 degrees angle of attack, and study of lateral dynamics and lateral control effectiveness at 40 and 50 degrees angle of attack. Each maneuver is to be realized by applying square wave inputs to specific control effectors using the On-Board Excitation System (OBES). Maneuver descriptions and complete specifications of the time/amplitude points define each input are included, along with plots of the input time histories.

  10. Synthesis, morphology and microstructure of pomegranate-like hematite ({alpha}-Fe{sub 2}O{sub 3}) superstructure with high coercivity

    Energy Technology Data Exchange (ETDEWEB)

    Tadic, Marin, E-mail: marint@vinca.rs [Condensed Matter Physics Laboratory, Vinca Institute, University of Belgrade, P.O. Box 522, 11001 Belgrade (Serbia); Citakovic, Nada [Military Academy, Generala Pavla Jurisica Sturma 33, University of Belgrade, 11000 Belgrade (Serbia); Panjan, Matjaz [Jozef Stefan Institute, Jamova 39, 1000 Ljubljana (Slovenia); Stanojevic, Boban [Vinca Institute of Nuclear Sciences, P.O. Box 522, 11001 Belgrade, University of Belgrade (Serbia); Markovic, Dragana [Condensed Matter Physics Laboratory, Vinca Institute, University of Belgrade, P.O. Box 522, 11001 Belgrade (Serbia); Jovanovic, Dorde [Center for Solid State Physics and New Materials, Institute of Physics, University of Belgrade, Pregrevica 118, 11080 Belgrade (Serbia); Spasojevic, Vojislav [Condensed Matter Physics Laboratory, Vinca Institute, University of Belgrade, P.O. Box 522, 11001 Belgrade (Serbia)

    2012-12-05

    Highlights: Black-Right-Pointing-Pointer We found superior magnetic properties of the hematite ({alpha}-Fe{sub 2}O{sub 3}). Black-Right-Pointing-Pointer TEM and HRTEM images show a pomegranate-like superstructure. Black-Right-Pointing-Pointer Magnetic measurements display high coercivity H{sub C} = 4350 Oe at the room temperature. - Abstract: We found novel and superior magnetic properties of the hematite ({alpha}-Fe{sub 2}O{sub 3}) that originate from an internal microstructure of particles and strong inter-particle interactions between nanocrystal sub-units. The hematite particles were synthesized by thermal decomposition of iron (III) nitrate without any template or surfactant. The purity, size, crystallinity, morphology, microstructure and magnetic features of the as-prepared particles were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), Raman spectroscopy (RS) and SQUID magnetometry. An XRD study reveals a pure phase of {alpha}-Fe{sub 2}O{sub 3} whereas TEM shows {alpha}-Fe{sub 2}O{sub 3} spheres with a diameter of about 150 nm. RS also shows high quality and purity of the sample. Moreover, TEM and HRTEM images show a pomegranate-like superstructure and evidence that the spherical particles are composed of individual well-crystallized nanoparticle sub-units (self-assembled nanoparticles) with a size of about 20 nm. Magnetic measurements display hysteretic behavior at the room temperature with remanent magnetization M{sub r} = 0.731 emu/g, saturation magnetization M{sub S} = 6.83 emu/g and coercivity H{sub C} = 4350 Oe, as well as the Morin transition at T{sub M} = 261 K. These results and comparison with those in the literature reveal that the sample has extremely high coercivity. The magnetic properties of the sample are discussed in relation to morphology, internal microstructure, surface

  11. Unwinding after high salinity stress: Pea DNA helicase 45 over- expression in tobacco confers high salinity tolerance without affecting yield (abstract)

    International Nuclear Information System (INIS)

    Tuteja, N.

    2005-01-01

    Soil salinity is an increasing threat for agriculture and is a major factor in reducing plant productivity; therefore, it is necessary to obtain salinity-tolerant varieties. A typical characteristic of soil salinity is the induction of multiple stress- inducible genes. Some of the genes encoding osmolytes, ion channels or enzymes are able to confer salinity-tolerant phenotypes when transferred to sensitive plants. As salinity stress affects the cellular gene-expression machinery, it is evident that molecules involved in nucleic acid processing including helicases, are likely to be affected as well. DNA helicases unwind duplex DNA and are involved in replication, repair, recombination and transcription while RNA helicases unfold the secondary structures in RNA and are involved in transcription, ribosome biogenesis and translation initiation. We have earlier reported the isolation of a pea DNA helicase 45 (PDH45) that exhibits striking homology with eIF-4A (Plant J. 24:219-230,2000). Here we report that PDH45 mRNA is induced in pea seedlings in response to high salt and its over- expression driven by a constitutive CAMV-355-promoter in tobacco plants confers salinity tolerance, thus suggesting a new pathway for manipulating stress tolerance in crop plants. The T0 transgenic plants showed high-levels of PDH45 protein in normal and stress conditions, as compared to wild type (WT) plants. The T0 transgenics also showed tolerance to high salinity as tested by a leaf disc senescence assay. The T1 transgenics were able to grow to maturity and set normal viable seeds under continuous salinity stress, without any reduction in plant yield, in terms of seed weight. Measurement of Na/sup +/ ions in different parts of the plant showed higher accumulation in the old leaves and negligible in seeds of T1 transgenic lines as compared with the WT plants. The possible mechanism of salinity tolerance will be discussed. Over-expression of PDH45 provides a possible example of the

  12. Do high progesterone concentrations decrease pregnancy rates in embryo recipients synchronized with PGF2alpha and eCG?

    Science.gov (United States)

    Nogueira, Marcelo F Gouveia; Melo, Danilas S; Carvalho, Luciano M; Fuck, Egon J; Trinca, Luzia A; Barros, Ciro Moraes

    2004-05-01

    The objective of this study was to evaluate the effects of equine chorionic gonadotropin (eCG) treatment on the number of induced accessory corpora lutea (CL), plasma progesterone concentrations and pregnancy rate in cross-bred heifers after transfer of frozen-thawed (1.5M ethylene glycol) embryos. All recipients received 500 microg PGF2alpha (dl-cloprostenol, i.m.) at random stages of the estrous cycle (Day 0) and were observed for estrus for 7 days. On Day 14, heifers detected in estrus between 2 and 7 days after PGF2alpha treatment were randomly allocated to four groups ( n=83 per group) and given 0 (control), 200, 400, or 600 IU of eCG. Two days later (Day 16), these recipients were given PGF2alpha and observed for estrus. Six to eight days after detection of estrus, plasma samples were collected to determine progesterone concentration and ultrasonography was performed to observe ovarian structures. Heifers with multiple CL or a single CL >15 mm in diameter received an embryo by direct transfer. Embryos of excellent and good quality were thawed and transferred to the recipients by the same veterinarian. Pregnancy was diagnosed by ultrasonography and confirmed by transrectal palpation 21 and 83 days after embryo transfer (ET), respectively. Plasma progesterone concentrations on the day of transfer (Day 7 of the estrous cycle) were 3.9+/-0.7, 4.2+/-0.4,6.0+/-0.4 and 7.8+/-0.6 ng/ml for groups Control, 200, 400, and 600, respectively (Control versus treated groups P=0.009; 200 versus 400 and 600 groups P=0.0001; and 400 versus 600 P=0.012 ). Conception rates 83 days after ET were 41.9, 50.0, 25.0, and 20.9% for groups Control, 200, 400, and 600, respectively (200 versus 400 and 600 groups P=0.0036 ). In conclusion, an increase in progesterone concentration, induced by eCG treatment, did not improve pregnancy rates in ET recipients. Conversely, there was a decline in conception rates in the animals with the highest plasma progesterone concentrations.

  13. Robust Protection against Highly Virulent Foot-and-Mouth Disease Virus in Swine by Combination Treatment with Recombinant Adenoviruses Expressing Porcine Alpha and Gamma Interferons and Multiple Small Interfering RNAs

    Science.gov (United States)

    Park, Jong-Hyeon; Lee, Kwang-Nyeong; Kim, Se-Kyung; You, Su-Hwa; Kim, Taeseong; Tark, Dongseob; Lee, Hyang-Sim; Seo, Min-Goo; Kim, Byounghan

    2015-01-01

    ABSTRACT Because the currently available vaccines against foot-and-mouth disease (FMD) provide no protection until 4 to 7 days postvaccination, the only alternative method to halt the spread of the FMD virus (FMDV) during outbreaks is the application of antiviral agents. Combination treatment strategies have been used to enhance the efficacy of antiviral agents, and such strategies may be advantageous in overcoming viral mechanisms of resistance to antiviral treatments. We have developed recombinant adenoviruses (Ads) for the simultaneous expression of porcine alpha and gamma interferons (Ad-porcine IFN-αγ) as well as 3 small interfering RNAs (Ad-3siRNA) targeting FMDV mRNAs encoding nonstructural proteins. The antiviral effects of Ad-porcine IFN-αγ and Ad-3siRNA expression were tested in combination in porcine cells, suckling mice, and swine. We observed enhanced antiviral effects in porcine cells and mice as well as robust protection against the highly pathogenic strain O/Andong/SKR/2010 and increased expression of cytokines in swine following combination treatment. In addition, we showed that combination treatment was effective against all serotypes of FMDV. Therefore, we suggest that the combined treatment with Ad-porcine IFN-αγ and Ad-3siRNA may offer fast-acting antiviral protection and be used with a vaccine during the period that the vaccine does not provide protection against FMD. IMPORTANCE The use of current foot-and-mouth disease (FMD) vaccines to induce rapid protection provides limited effectiveness because the protection does not become effective until a minimum of 4 days after vaccination. Therefore, during outbreaks antiviral agents remain the only available treatment to confer rapid protection and reduce the spread of foot-and-mouth disease virus (FMDV) in livestock until vaccine-induced protective immunity can become effective. Interferons (IFNs) and small interfering RNAs (siRNAs) have been reported to be effective antiviral agents against

  14. 15th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2009-01-01

    This is the 15th volume in the conference series. Over the years the International Cryocooler Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  15. 14th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2007-01-01

    This is the 14th volume in the conference series. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  16. Treatment of solid waste highly contaminated by alpha emitters. Recent developments of leaching process with continuous electrolyte regeneration

    International Nuclear Information System (INIS)

    Madic, C.

    1990-01-01

    In the recent years, efforts have been made in order to reduce the amount of alpha emitters essentially plutonium isotopes present in the solid wastes produced during research experiments on fuel reprocessing. Leaching processes using electrogenerated Ag (II(a very agressive agent for PuO 2 )) in nitric acid solutions, were developed and several facilities were designed and built to operate the processes: (1) ELISE and PROLIXE facilities, for the treatment of α and α, β, γ solid wastes (CEA, FONTENAY-AUX-ROSES) (2) PILOT ASHES FACILITY for delete, the treatment of plutonium contaminated ashes (COGEMA, MARCOULE). A brief description of the process and of the different facilities is presented; the main results obtained in ELISE and PROLIXE are also summarized

  17. Optimization of the detector and associated electronics used for high-resolution liquid-scintillation alpha spectroscopy

    International Nuclear Information System (INIS)

    Thorngate, J.H.; Christian, D.J.

    1977-01-01

    The performance of various reflector geometries, light coupling liquids, photomultiplier tubes, preamplifiers and linear amplifiers were compared and the configuration found that optimized the combination of pulse-height resolution and pulse-shape discrimination. The best combination used a hemispherical reflector, filled with distilled water, coupled to an 8575 photomultiplier tube, the output of which was conditioned by a special integrating preamplifier and a double-delay-line linear amplifier. Careful choice of the scintillator, sample preparation procedures, and electronic apparatus can produce liquid-scintillation alpha spectroscopy with a pulse-height resolution of 300 keV, or less, and, by using pulse-shape discrimination, background levels as low as 0.01 counts/min. (author)

  18. Alpha heating in toroidal devices

    International Nuclear Information System (INIS)

    Miley, G.H.

    1978-01-01

    Ignition (or near-ignition) by alpha heating is a key objective for the achievement of economic fusion reactors. While good confinement of high-energy alphas appears possible in larger reactors, near-term tokamak-type ignition experiments as well as some concepts for small reactors (e.g., the Field-Reversed Mirror or FRM) potentially face marginal situations. Consequently, there is a strong motivation to develop methods to evaluate alpha losses and heating profiles in some detail. Such studies for a TFTR-size tokamak and for a small FRM are described here

  19. Hamburg Accelerator Conference

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Edmund J.N. [CERN Accelerator School (Switzerland)

    1992-10-15

    From 20-24 July, Hamburg welcomed the Fifteenth International Conference on High Energy Accelerators (HEACC). A natural highlight was the recent commissioning success of the HERA electron-proton collider at Hamburg's DESY Laboratory and its first high energy electron-proton collision data. This gave the meeting the feel of a family event celebrating a newborn.

  20. Hamburg Accelerator Conference

    International Nuclear Information System (INIS)

    Wilson, Edmund J.N.

    1992-01-01

    From 20-24 July, Hamburg welcomed the Fifteenth International Conference on High Energy Accelerators (HEACC). A natural highlight was the recent commissioning success of the HERA electron-proton collider at Hamburg's DESY Laboratory and its first high energy electron-proton collision data. This gave the meeting the feel of a family event celebrating a newborn

  1. Mendel conference

    CERN Document Server

    2015-01-01

    This book is a collection of selected accepted papers of Mendel conference that has been held in Brno, Czech Republic in June 2015. The book contents three chapters which represent recent advances in soft computing including intelligent image processing and bio-inspired robotics.: Chapter 1: Evolutionary Computing, and Swarm intelligence, Chapter 2: Neural Networks, Self-organization, and Machine Learning, and Chapter3: Intelligent Image Processing, and Bio-inspired Robotics. The Mendel conference was established in 1995, and it carries the name of the scientist and Augustinian priest Gregor J. Mendel who discovered the famous Laws of Heredity. In 2015 we are commemorating 150 years since Mendel's lectures, which he presented in Brno on February and March 1865. The main aim of the conference was to create a periodical possibility for students, academics and researchers to exchange their ideas and novel research methods.  .

  2. Multiple cold resistance loci confer the high cold tolerance adaptation of Dongxiang wild rice (Oryza rufipogon) to its high-latitude habitat.

    Science.gov (United States)

    Mao, Donghai; Yu, Li; Chen, Dazhou; Li, Lanying; Zhu, Yuxing; Xiao, Yeqing; Zhang, Dechun; Chen, Caiyan

    2015-07-01

    Dongxiang wild rice is phylogenetically close to temperate japonica and contains multiple cold resistance loci conferring its adaptation to high-latitude habitat. Understanding the nature of adaptation in wild populations will benefit crop breeding in the development of climate-resilient crop varieties. Dongxiang wild rice (DXWR), the northernmost common wild rice known, possesses a high degree of cold tolerance and can survive overwintering in its native habitat. However, to date, it is still unclear how DXWR evolved to cope with low-temperature environment, resulting in limited application of DXWR in rice breeding programs. In this study, we carried out both QTL mapping and phylogenetic analysis to discern the genetic mechanism underlying the strong cold resistance. Through a combination of interval mapping and single locus analysis in two genetic populations, at least 13 QTLs for seedling cold tolerance were identified in DXWR. A phylogenetic study using both genome-wide InDel markers and markers associated with cold tolerance loci reveals that DXWR belongs to the Or-III group, which is most closely related to cold-tolerant Japonica rice rather than to the Indica cultivars that are predominant in the habitat where DXWR grows. Our study paves the way toward an understanding of the nature of adaptation to a northern habitat in O. rufipogon. The QTLs identified in DXWR in this study will be useful for molecular breeding of cold-tolerant rice.

  3. AlphaScreen-based homogeneous assay using a pair of 25-residue artificial proteins for high-throughput analysis of non-native IgG.

    Science.gov (United States)

    Senga, Yukako; Imamura, Hiroshi; Miyafusa, Takamitsu; Watanabe, Hideki; Honda, Shinya

    2017-09-29

    Therapeutic IgG becomes unstable under various stresses in the manufacturing process. The resulting non-native IgG molecules tend to associate with each other and form aggregates. Because such aggregates not only decrease the pharmacological effect but also become a potential risk factor for immunogenicity, rapid analysis of aggregation is required for quality control of therapeutic IgG. In this study, we developed a homogeneous assay using AlphaScreen and AF.2A1. AF.2A1 is a 25-residue artificial protein that binds specifically to non-native IgG generated under chemical and physical stresses. This assay is performed in a short period of time. Our results show that AF.2A1-AlphaScreen may be used to evaluate the various types of IgG, as AF.2A1 recognizes the non-native structure in the constant region (Fc region) of IgG. The assay was effective for detection of non-native IgG, with particle size up to ca. 500 nm, generated under acid, heat, and stirring conditions. In addition, this technique is suitable for analyzing non-native IgG in CHO cell culture supernatant and mixed with large amounts of native IgG. These results indicate the potential of AF.2A1-AlphaScreen to be used as a high-throughput evaluation method for process monitoring as well as quality testing in the manufacturing of therapeutic IgG.

  4. International conference on high-energy physics. Volume 1. Sessions I to III. [Geneva, June 27-July 4, 1979

    Energy Technology Data Exchange (ETDEWEB)

    1980-02-01

    Volume 1 of the conference proceedings contains sessions on neutrino physics and weak interactions, e/sup +/e/sup -/ physics, and theory. Five of the papers have already been cited in ERA, and can be found by reference to the entry CONF-790642-- in the Report Number Index. The remaining 30 will be processed as they are received on the Atomindex tape. (RWR)

  5. High Technology and Education. Proceedings of Fueling the Education Explosion Conference 4 (Cleveland, Ohio, September 20-21, 1984).

    Science.gov (United States)

    Gardner, Mary, Ed.; Reed-Mundell, Charlene, Ed.

    This document provides nine papers presented at a 2-day conference where representatives of the National Aeronautics and Space Administration (NASA) described the future of space exploration and discussed the implications of that future for educators. The proceedings begins with an introduction by Ralph Winrich, NASA Aerospace Education…

  6. 17th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2012-01-01

    Cryocoolers 17 archives developments and performance measurements in the field of cryocoolers based on the contributions of leading international experts at the 17th International Cryocooler Conference that was held in Los Angeles, California, on July 9-12, 2012. The program of this conference consisted of 94 papers; of these, 71 are published here. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  7. 16th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2011-01-01

    Cryocoolers 16 archives developments and performance measurements in the field of cryocoolers based on the contributions of leading international experts at the 16th International Cryocooler Conference that was held in Atlanta, Georgia, on May 17-20, 2010. The program of this conference consisted of 116 papers; of these, 89 are published here. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  8. Alpha scintillation radon counting

    International Nuclear Information System (INIS)

    Lucas, H.F. Jr.

    1977-01-01

    Radon counting chambers which utilize the alpha-scintillation properties of silver activated zinc sulfide are simple to construct, have a high efficiency, and, with proper design, may be relatively insensitive to variations in the pressure or purity of the counter filling. Chambers which were constructed from glass, metal, or plastic in a wide variety of shapes and sizes were evaluated for the accuracy and the precision of the radon counting. The principles affecting the alpha-scintillation radon counting chamber design and an analytic system suitable for a large scale study of the 222 Rn and 226 Ra content of either air or other environmental samples are described. Particular note is taken of those factors which affect the accuracy and the precision of the method for monitoring radioactivity around uranium mines

  9. Innovations in Los Alamos alpha box design

    International Nuclear Information System (INIS)

    Ledbetter, J.M.; Dowler, K.E.; Cook, J.H.

    1985-01-01

    Destructive examinations of irradiated fuel pins containing plutonium fuel must be performed in shielded hot cells with strict provisions for containing the plutonium. Alpha boxes provide containment for the plutonium, toxic fission products, and other hazardous highly radioactive materials. The alpha box contains windows for viewing and a variety of transfer systems specially designed to allow transfers in and out of the alpha box without spread of the hazardous materials that are contained in the box. Alpha boxes have been in use in the Wing 9 hot cells at Los Alamos National Laboratory for more than 20 years. Features of the newly designed alpha boxes are presented

  10. Impact of conference attendance on librarians' leadership ...

    African Journals Online (AJOL)

    ... attendance to leadership developments hows approximately 0.370.m Conference attendance was highly recommended as a means of enhancing leadership development of academic librarians. Keywords: Experiential learning, self efficacy, attitude, Conference, Impact, Leadership, Teamwork, development, brainstorm, ...

  11. Characterization of high specific activity [16 alpha-123I]Iodo-17 beta-estradiol as an estrogen receptor-specific radioligand capable of imaging estrogen receptor-positive tumors

    International Nuclear Information System (INIS)

    Pavlik, E.J.; Nelson, K.; Gallion, H.H.; van Nagell, J.R. Jr.; Donaldson, E.S.; Shih, W.J.; Spicer, J.A.; Preston, D.F.; Baranczuk, R.J.; Kenady, D.E.

    1990-01-01

    16 alpha-[123I]Iodo-17 beta-estradiol (16 alpha-[123I]E2) has been characterized for use as a selective radioligand for estrogen receptor (ERc) that is capable of generating in situ images of ERc-positive tumors. High specific activity 16 alpha-[123I]E2 (7,500-10,000 Ci/mmol) was used in all determinations. Radiochemical purity was determined by thin layer chromatography, and the selectivity of radioligand for ERc was evaluated using size exclusion high performance liquid chromatography on ERc prepared from rodent uteri. Efficiencies of radioidination approaching 100% were achieved, and excellent receptor selectivity was obtained even when the efficiency of radioiodination was as low as 10%. Low radiochemical purity was always associated with poor selectivity for ERc. No new radioligand species was generated during the course of radiodecay; however, reduced binding over time, even when increased activity was used to compensate for radiodecay, indicated that the formation of a radioinert competitor does occur. 16 alpha-[123I]E2 demonstrated stable, high affinity binding to ERc and was concentrated by ERc-positive tissues. After injecting 16 alpha-[123I]E2 in vivo, images of ERc-containing tissues were obtained, including rabbit reproductive tract and dimethylbenzanthracene-induced tumors. The demonstrations of ERc selectivity and image formation both indicate that 16 alpha-[123I]E2 should have promise as a useful new radiopharmaceutical for imaging ERc-positive cancers

  12. Conference proceedings

    African Journals Online (AJOL)

    ebutamanya

    2016-02-29

    Feb 29, 2016 ... In addition, there are persistent problems with leadership and planning, vaccine stock management, supply chain capacity and quality, provider-parent communication, and financial sustainability. The conference delegates agreed to move from talking to taking concrete actions around children's health, and ...

  13. Conference summary

    International Nuclear Information System (INIS)

    Clark, D.J.

    1975-10-01

    A brief review is given of the main results presented at the International Conference on Heavy Ion Sources, October 27--30, 1975. The sections are as follows: highlights, general observations, fundamental processes in sources, positive ion sources, negative ion sources, beam formation and emittance measurements, stripping, accelerators and experiments, and future prospects

  14. Conference report

    African Journals Online (AJOL)

    Tamara Shefer

    Bloomberg Philanthropies. The conference theme “from research to implementation” emphasised the importance of connecting knowledge around violence with injury prevention, while stressing the need to address the multitude of transnational public health challenges. In speaking to this theme, the. Tampere Declaration ...

  15. Conference Planning.

    Science.gov (United States)

    Carter, Richard

    1982-01-01

    Presents an overview of the management planning technique known as Break Even Analysis and outlines its use as a tool in financial planning for organizations intending to conduct or sponsor a conference, seminar, or workshop. Three figures illustrating Break Even Analysis concepts and a Break Even Analysis worksheet are included. (JL)

  16. Conference proceedings

    African Journals Online (AJOL)

    abp

    2015-08-07

    Aug 7, 2015 ... Conference was organized in June 2-6, 2014 at the Yaoundé Mont Febe Hotel, in Cameroon. Under the theme«Practice .... while the implementation of family planning in African HIV programs will favor safe contraception ... equipment. The WHO-stepwise approach for the global strategy for the prevention ...

  17. Conference summaries

    International Nuclear Information System (INIS)

    1983-01-01

    The papers presented at this conference cover the fields of thermalhydraulics, nuclear plant design and operation, licensing, decontamination, restoration and dismantling of nuclear power facilities, services to the nuclear industry, new applications of nuclear technology, reactor physics and fuel cycles, accelerator-breeders, fusion research and lasers

  18. Active tuberculosis patients have high levels of IgA anti-alpha-crystallin and isocitrate lyase proteins.

    Science.gov (United States)

    Talavera-Paulín, M; García-Morales, L; Ruíz-Sánchez, B P; Caamal-Ley, Á D; Hernández-Solis, A; Ramírez-Casanova, E; Cicero-Sabido, R; Espitia, C; Helguera-Repetto, C; González-Y-Merchand, J A; Flores-Mejía, R; Estrada-Parra, S; Estrada-García, I; Chacón-Salinas, R; Wong-Baeza, I; Serafín-López, J

    2016-12-01

    Mexico City, Mexico. To identify proteins synthetised by Mycobacterium tuberculosis in hypoxic culture, which resemble more closely a granuloma environment than aerobic culture, and to determine if they are recognised by antibodies from patients with active pulmonary tuberculosis (PTB). Soluble extracts from M. tuberculosis H37Rv cultured under aerobic or hypoxic conditions were analysed using two-dimensional polyacrylamide gel electrophoresis, and proteins over-expressed under hypoxia were identified by mass spectrometry. The presence of immunoglobulin (Ig) G, IgA and IgM antibodies against these proteins was determined in the serum of 42 patients with active PTB and 42 healthy controls. We selected three M. tuberculosis H37Rv proteins (alpha-crystallin protein [Acr, Rv2031c], universal stress protein Rv2623 and isocitrate lyase [ICL, RV0467]) that were over-expressed under hypoxia. Titres of anti-Acr and anti-ICL IgA antibodies were higher in patients than in healthy controls, with an area under the receiver operating characteristic curve of 0.71 for anti-ICL IgA antibodies. ICL could be used in combination with other M. tuberculosis antigens to improve the sensitivity and specificity of current serological TB diagnostic methods.

  19. The Future of Inner City High Schools: The Public-Private Contribution. Proceedings of Conference "The Future of Inner City High Schools: The Public-Private Contribution" (Boston, Massachusetts, June 21-22, 1984).

    Science.gov (United States)

    Harvard Univ., Cambridge, MA. Kennedy School of Government.

    This document summarizes the proceedings of a conference of urban leaders on public-private collaborative efforts to address the problems of inner-city high schools. Findings presented and opinions expressed at sessions on the following topics are outlined: (1) education funds; (2) city-wide umbrella organizations; (3) goal setting--tying jobs and…

  20. High sensitivity boron quantification in bulk silicon using the {sup 11}B(p,{alpha}{sub 0}){sup 8}Be nuclear reaction

    Energy Technology Data Exchange (ETDEWEB)

    Moro, Marcos V.; Silva, Tiago F. da; Added, Nemitala; Rizutto, Marcia A.; Tabacniks, Manfredo H. [Instituto de Fisica da Universidade de Sao Paulo, C.P. 66318, 05315-970 Sao Paulo, SP (Brazil); Neira, John B.; Neto, Joao B. F. [Institute of Research Tecnology, Cidade Universitaria, SP, 05508-091 (Brazil)

    2013-05-06

    There is a great need to quantify sub-ppm levels of boron in bulk silicon. There are several methods to analyze B in Si: Nuclear Reaction Analysis using the {sup 11}B(p,{alpha}{sub 0}){sup 8}Be reaction exhibits a quantification limit of some hundreds ppm of B in Si. Heavy Ion Elastic Recoil Detection Analysis offers a detection limit of 5 to 10 at. ppm. Secondary Ion Mass Spectrometry is the method of choice of the semiconductor industry for the analysis of B in Si. This work verifies the use of NRA to quantify B in Si, and the corresponding detection limits. Proton beam with 1.6 up to 2.6 MeV was used to obtain the cross-section of the {sup 11}B(p,{alpha}{sub 0}){sup 8}Be nuclear reaction at 170 Degree-Sign scattering angle. The results show good agreementwith literature indicating that the quantification of boron in silicon can be achieved at 100 ppm level (high sensitivity) at LAMFI-IFUSP with about 16% uncertainty. Increasing the detection solid angle and the collected beam charge, can reduce the detection limit to less than 100 ppm meeting present technological needs.

  1. Reversible, PET-positive, generalized lymphadenopathy and splenomegaly during high-dose interferon-alpha-2b adjuvant therapy for melanoma.

    Science.gov (United States)

    Ridolfi, Laura; Cangini, Delia; Galassi, Riccardo; Passardi, Alessandro; Marzullo, Annamaria; Moretti, Andrea; Framarini, Massimo; Tauceri, Francesca; Serra, Luigi; Chiarion-Sileni, Vanna; Ridolfi, Ruggero

    2008-09-01

    A patient with resected stage III nodular melanoma treated with high-dose interferon-alpha-b2 adjuvant therapy went on to develop generalized lymphadenopathy and splenomegaly. The total body positron emission tomography showed a high F-fluorodeoxyglucose uptake (standardized uptake values >9), indicating possible lymph node and spleen malignancies. Histologic examinations of an axillary lymph node biopsy and an osteomedullar biopsy were negative, excluding both melanoma metastases and hematopoietic tumors. The symptoms completely regressed after suspension of treatment and a follow-up positron emission tomography was negative. It remains to be seen whether this unusual event can be ascribed to an autoimmune phenomenon linked to potential treatment efficacy and survival.

  2. Two forms of acid alpha-D-mannosidase in monkey brain: evidence for the co-existence of high mannose and complex oligosaccharides in one form.

    Science.gov (United States)

    Mathur, R; Alvares, K; Balasubramanian, A S

    1984-09-28

    Lysosomal alpha-D-mannosidase of monkey brain existed in two forms. One form of mannosidase was bound to the Ricinus communis agglutinin120 (RCA1)-Sepharose and could be specifically eluted with lactose. The other form did not bind to the RCA1-Sepharose. Both forms of mannosidase could bind to a similar extent to the immobilized brain lysosomal receptor protein. Both the forms were purified to apparent homogeneity. Neutral sugar analysis by GLC showed the presence of glucose, mannose and galactose in the RCA1-Sepharose bindable mannosidase and glucose and mannose in the non-bindable mannosidase. Several other brain lysosomal hydrolases did not bind to the RCA1-Sepharose. The results suggested the existence of only high mannose oligosaccharides in the RCA1 non-bindable mannosidase and both high mannose and complex oligosaccharides in the bindable mannosidase.

  3. CONFERENCE: Nuclear visions

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    Last summer, four hundred visitors of about 30 different nationalities descended on the ancient town of Visby on the Swedish island of Gotland for the Second International Conference on Nucleus-Nucleus Collisions. For the conference itself, sessions were organized not according to conventional topics like low, intermediate and high energy reactions, but along phenomena-related lines that brought listeners together instead of splitting them up. Examples were 'phase transitions', 'new facilities' and 'breaking nuclear matter into pieces'

  4. Vienna wirechamber conference 98

    International Nuclear Information System (INIS)

    1998-02-01

    This volume of the Vienna wirechamber conference 1998 contains abstracts of lectures and abstracts of poster sessions of the following topics: high energy physics, gaseous detectors, radiation detectors, calorimetry, drift chambers, wire spark chambers, tracking chambers, neutron detectors, particle detection, muon spectrometry, nuclear medicine. (Suda)

  5. CONFERENCE: Quark matter 88

    International Nuclear Information System (INIS)

    Jacob, Maurice

    1988-01-01

    The 'Quark Matter' Conference caters for physicists studying nuclear matter under extreme conditions. The hope is that relativistic (high energy) heavy ion collisions allow formation of the long-awaited quark-gluon plasma, where the inter-quark 'colour' force is no longer confined inside nucleon-like dimensions

  6. High-resolution mapping reveals linkage between genes in common bean cultivar Ouro Negro conferring resistance to the rust, anthracnose, and angular leaf spot diseases.

    Science.gov (United States)

    Valentini, Giseli; Gonçalves-Vidigal, Maria Celeste; Hurtado-Gonzales, Oscar P; de Lima Castro, Sandra Aparecida; Cregan, Perry B; Song, Qijian; Pastor-Corrales, Marcial A

    2017-08-01

    Co-segregation analysis and high-throughput genotyping using SNP, SSR, and KASP markers demonstrated genetic linkage between Ur-14 and Co-3 4 /Phg-3 loci conferring resistance to the rust, anthracnose and angular leaf spot diseases of common bean. Rust, anthracnose, and angular leaf spot are major diseases of common bean in the Americas and Africa. The cultivar Ouro Negro has the Ur-14 gene that confers broad spectrum resistance to rust and the gene cluster Co-3 4 /Phg-3 containing two tightly linked genes conferring resistance to anthracnose and angular leaf spot, respectively. We used co-segregation analysis and high-throughput genotyping of 179 F 2:3 families from the Rudá (susceptible) × Ouro Negro (resistant) cross-phenotyped separately with races of the rust and anthracnose pathogens. The results confirmed that Ur-14 and Co-3 4 /Phg-3 cluster in Ouro Negro conferred resistance to rust and anthracnose, respectively, and that Ur-14 and the Co-3 4 /Phg-3 cluster were closely linked. Genotyping the F 2:3 families, first with 5398 SNPs on the Illumina BeadChip BARCBEAN6K_3 and with 15 SSR, and eight KASP markers, specifically designed for the candidate region containing Ur-14 and Co-3 4 /Phg-3, permitted the creation of a high-resolution genetic linkage map which revealed that Ur-14 was positioned at 2.2 cM from Co-3 4 /Phg-3 on the short arm of chromosome Pv04 of the common bean genome. Five flanking SSR markers were tightly linked at 0.1 and 0.2 cM from Ur-14, and two flanking KASP markers were tightly linked at 0.1 and 0.3 cM from Co-3 4 /Phg-3. Many other SSR, SNP, and KASP markers were also linked to these genes. These markers will be useful for the development of common bean cultivars combining the important Ur-14 and Co-3 4 /Phg-3 genes conferring resistance to three of the most destructive diseases of common bean.

  7. PREFACE: Rutherford Centennial Conference on Nuclear Physics

    Science.gov (United States)

    Freeman, Sean

    2012-09-01

    Just over one hundred years ago, Ernest Rutherford presented an interpretation of alpha-particle scattering experiments, performed a couple of years earlier by Geiger and Marsden, to the Manchester Literary and Philosophical Society. The work was summarised shortly afterwards in a paper in the Philosophical Magazine. He postulated that a dense speck of matter must exist at the centre of an atom (later to become known as the nucleus) if the details of the experiments, particularly the yield of alpha particles scattered through large angles, were to be explained. The nuclear hypothesis, combined with the experimental work by Moseley on X-rays and Bohr's theoretical ideas, both also initiated at the Victoria University of Manchester, established our view of atomic structure and gave birth to the field of nuclear physics. The Rutherford Centennial Conference on Nuclear Physics was held at The University of Manchester in August 2011 to celebrate this anniversary by addressing the wide range of contemporary topics that characterise modern nuclear physics. This set of proceedings covers areas including nuclear structure and astrophysics, hadron structure and spectroscopy, fundamental interactions studied within the nucleus and results of relativistic heavy-ion collisions. We would like to thank all those who presented their recent research results at the conference; the proceedings stand as a testament to the excitement and interest that still pervades the pursuit of this field of physics. We would also like to thank those who contributed in other ways to the conference. To colleagues at the Manchester Museum of Science and Industry for putting together an exhibition to coincide with the conference that included the manuscript of the 1911 paper, letters, notebooks and equipment used by Rutherford. These items were kindly loaned by Cambridge and Manchester Universities. Winton Capital generously supported this exhibition. We would also like to thank Professor Mary Fowler

  8. Conference Proceedings

    International Nuclear Information System (INIS)

    1998-01-01

    National and international aspects of climate change were the central concern of this conference organized by the Alliance for Responsible Environmental Alternatives (AREA). AREA is a coalition of industry, labour and municipalities from across Canada which was created to reflect the views and represent the interests of Canadians in the Climate Change Debate. Ways and means of optimizing Canada's response to the Global Climate Change Challenge were discussed. Discussions emphasized issues regarding the effectiveness of voluntary mechanisms to reduce greenhouse gases, as opposed to government-mandated actions for achieving climate change targets. The issue of how a differentiated system for emission reduction targets and timetables can be implemented was also debated. The economic implications of climate change were outlined. Canada's national agenda and the likely outcomes of the Conference of Parties (COP 4) in Buenos Aires also received much attention. tabs., figs

  9. SIGEF Conference

    CERN Document Server

    Terceño-Gómez, Antonio; Ferrer-Comalat, Joan; Merigó-Lindahl, José; Linares-Mustarós, Salvador

    2015-01-01

    This book is a collection of selected papers presented at the SIGEF conference, held at the Faculty of Economics and Business of the University of Girona (Spain), 06-08 July, 2015. This edition of the conference has been presented with the slogan “Scientific methods for the treatment of uncertainty in social sciences”. There are different ways for dealing with uncertainty in management. The book focuses on soft computing theories and their role in assessing uncertainty in a complex world. It gives a comprehensive overview of quantitative management topics and discusses some of the most recent developments in all the areas of business and management in soft computing including Decision Making, Expert Systems and Forgotten Effects Theory, Forecasting Models, Fuzzy Logic and Fuzzy Sets, Modelling and Simulation Techniques, Neural Networks and Genetic Algorithms and Optimization and Control. The book might be of great interest for anyone working in the area of management and business economics and might be es...

  10. Conference summaries

    International Nuclear Information System (INIS)

    1987-01-01

    This volume contains summaries of 28 papers presented at the 27. conference of the Canadian Nuclear Association. These papers discuss the general situation of the Canadian nuclear industry and the CANDU reactor; dialogue with the public; the International Atomic Energy Agency; and economic goals and operating lessons. It also contains summaries of 70 papers presented at the 8. conference of the Canadian Nuclear Society, which discuss plant life extension; safety and the environment; reactor physics; thermalhydraulics; risk assessment; the CANDU spacer location and repositioning project; CANDU operations; safety research after Chernobyl; fuel channels; and nuclear technology developments. The individual papers are also available in INIS-mf--13673 (CNA), and INIS-mf--12909 (CNS). (L.L.)

  11. Design Specification for a Thrust-Vectoring, Actuated-Nose-Strake Flight Control Law for the High-Alpha Research Vehicle

    Science.gov (United States)

    Bacon, Barton J.; Carzoo, Susan W.; Davidson, John B.; Hoffler, Keith D.; Lallman, Frederick J.; Messina, Michael D.; Murphy, Patrick C.; Ostroff, Aaron J.; Proffitt, Melissa S.; Yeager, Jessie C.; hide

    1996-01-01

    Specifications for a flight control law are delineated in sufficient detail to support coding the control law in flight software. This control law was designed for implementation and flight test on the High-Alpha Research Vehicle (HARV), which is an F/A-18 aircraft modified to include an experimental multi-axis thrust-vectoring system and actuated nose strakes for enhanced rolling (ANSER). The control law, known as the HARV ANSER Control Law, was designed to utilize a blend of conventional aerodynamic control effectors, thrust vectoring, and actuated nose strakes to provide increased agility and good handling qualities throughout the HARV flight envelope, including angles of attack up to 70 degrees.

  12. High-dispersion observations of H-alpha in the suspected brown dwarf, white dwarf binary system G29-38

    International Nuclear Information System (INIS)

    Liebert, J.; Saffer, R.A.; Pilachowski, C.A.

    1989-01-01

    High-dispersion spectroscopy of the H-alpha absorption line of the cool DA white dwarf G29-38 is reported. This is the star for which a recently detected IR excess has been suggested to be due to a possible brown dwarf companion. Three echelle spectra show no evidence for radial-velocity variations larger than about 1.1 + or - 8.7 km/s and are used to derive a weighted heliocentric radial velocity of 33.7 + or - 4.3 kms/s for the white dwarf. The observations of a sharp absorption-line core restricts the possible rotation of the white dwarf to 40 km/s or less and ensures that any surface magnetic field has a strength of 100,000 G or less. These results make it unlikely that the DA white dwarf has previously been in a cataclysmic variable accretion phase. 18 references

  13. Mapping of barley alpha-amylases and outer subsite mutants reveals dynamic high-affinity subsites and barriers in the long substrate binding cleft

    DEFF Research Database (Denmark)

    Kandra, L.; Abou Hachem, Maher; Gyemant, G.

    2006-01-01

    Subsite affinity maps of long substrate binding clefts in barley alpha-amylases, obtained using a series of maltooligosaccharides of degree of polymerization of 3-12, revealed unfavorable binding energies at the internal subsites -3 and -5 and at subsites -8 and +3/+4 defining these subsites...... as binding barriers. Barley a-amylase I mutants Y105A and T212Y at subsite -6 and +4 resulted in release or anchoring of bound substrate, thus modifying the affinities of other high-affinity subsites (-2 and +2) and barriers. The double mutant Y105A-T212Y displayed a hybrid subsite affinity profile......, converting barriers to binding areas. These findings highlight the dynamic binding energy distribution and the versatility of long maltooligosaccharide derivatives in mapping extended binding clefts in a-amylases....

  14. Making Conferences Human Places of Learning

    Science.gov (United States)

    Kenny, Michael

    2014-01-01

    Open Space Technology is a cumbersome name for a participative conference model that enables dynamic inclusive engagement and challenges traditional, highly structured hierarchical conference formats. Based on self-organising systems, (Wenger, 1998) Open Space Technology conferences have an open process, start with no agenda and empower the most…

  15. Bi209 alpha activity

    International Nuclear Information System (INIS)

    Araujo Penna, M.M. de.

    1970-01-01

    The study for measuring Bi 209 alpha activity is presented. Ilford L4 nuclear emulsion pellicles loaded with bismuth citrate to obtain a load of 100 mg/cm 3 of dry emulsion, were prepared. Other pellicles were prepared with the same. Ilford L4 gel to estimate the background radiation. To observe 'fading' effect, pellicles loaded with bismuth were submitted to neutrons of high energy, aiming to record recoil proton tracks. The pellicles were confined in nitrogen atmosphere at temperature lower than -10 0 C. The Bi 209 experimental half-life was obtained and compared with the estimated theoretical data. (M.C.K.) [pt

  16. Alpha particle studies during JET DT experiments

    International Nuclear Information System (INIS)

    1999-01-01

    The 1997 DT experiment (DTE1) at the Joint European Torus included studies of the behaviour of alpha particles in high temperature plasmas. Clear alpha particle heating was observed in a series of otherwise similar 10MW hot-ion H-modes by scanning the DT mixture from 0%T to 93%T. Maxima in central temperature and energy content were obtained which corresponded with the maximum in fusion yield. Alfven Eigenmodes (AEs) have been detected in JET, driven by NBI or ICRH fast ions. However, in agreement with theory, no AE activity was observed in DT plasmas which could be attributed to alpha particle drive, except in the afterglow of some Optimised Shear pulses. Ion Cyclotron Emission (ICE) was detected at harmonics of the alpha particle cyclotron frequency at the outer edge of the plasma. The ICE is interpreted as being close to magnetoacoustic cyclotron instability, driven by inverted alpha distributions at the plasma edge. The high-energy neutral particle spectra showed features, which are ascribed to a mixture of alphas, neutralised by helium-like impurities, and deuterons, born from elastic collisions with alpha particles and neutralised by hydrogen-like impurities. The results of all these studies are consistent with classical alpha particle trapping and slowing-down. Future DT experiments will aim to increase alpha particle pressure, so interactions with plasma instabilities can be studied. The measurement of knock-on neutral triton spectra offers a clean way to determine confined alpha densities in these future experiments. (author)

  17. Alpha particle studies during JET DT experiments

    International Nuclear Information System (INIS)

    2001-01-01

    The 1997 DT experiment (DTE1) at the Joint European Torus included studies of the behaviour of alpha particles in high temperature plasmas. Clear alpha particle heating was observed in a series of otherwise similar 10MW hot-ion H-modes by scanning the DT mixture from 0%T to 93%T. Maxima in central temperature and energy content were obtained which corresponded with the maximum in fusion yield. Alfven Eigenmodes (AEs) have been detected in JET, driven by NBI or ICRH fast ions. However, in agreement with theory, no AE activity was observed in DT plasmas which could be attributed to alpha particle drive, except in the afterglow of some Optimised Shear pulses. Ion Cyclotron Emission (ICE) was detected at harmonics of the alpha particle cyclotron frequency at the outer edge of the plasma. The ICE is interpreted as being close to magnetoacoustic cyclotron instability, driven by inverted alpha distributions at the plasma edge. The high-energy neutral particle spectra showed features, which are ascribed to a mixture of alphas, neutralised by helium-like impurities, and deuterons, born from elastic collisions with alpha particles and neutralised by hydrogen-like impurities. The results of all these studies are consistent with classical alpha particle trapping and slowing-down. Future DT experiments will aim to increase alpha particle pressure, so interactions with plasma instabilities can be studied. The measurement of knock-on neutral triton spectra offers a clean way to determine confined alpha densities in these future experiments. (author)

  18. Alpha Channeling in Rotating Plasma with Stationary Waves

    International Nuclear Information System (INIS)

    Fetterman, A.; Fisch, N.J.

    2010-01-01

    An extension of the alpha channeling effect to supersonically rotating mirrors shows that the rotation itself can be driven using alpha particle energy. Alpha channeling uses radiofrequency waves to remove alpha particles collisionlessly at low energy. We show that stationary magnetic fields with high n θ can be used for this purpose, and simulations show that a large fraction of the alpha energy can be converted to rotation energy.

  19. Alpha Meals

    Directory of Open Access Journals (Sweden)

    Myra A. Fernandes

    2013-05-01

    Full Text Available Past research suggests that our ability to recall information increases when atypical items are presented within otherwise homogeneous sets. We investigated whether this effect applied to performance on practical, everyday tasks. In a computer-simulated restaurant scenario, participants acted as virtual servers, delivering “plates of food orders” to tables set up in different “rooms.” Plate destination was communicated using either a distinctive alphanumeric code or a homogeneous numeric code, both of which indicated the room and table number for delivery of food orders. We examined accuracy of plate delivery when two (low load or three (high load coded assignments were given per delivery trial. As expected, performance declined from the low- to high-load condition. Importantly, performance declined less with alphanumeric compared with all-numeric communication of assignments. Results suggest that increasing the distinctiveness of assignments, by using alphanumeric codes, can boost performance in real-life situations to significantly improve memory-related task performance, particularly when cognitive load is taxed.

  20. Effects of a high-pressure treatment on the wheat alpha-amylase inhibitor and its relationship to elimination of allergenicity

    Science.gov (United States)

    Yamamoto, S.; Takanohashi, K.; Hara, T.; Odani, S.; Suzuki, A.; Nishiumi, T.

    2010-03-01

    In this study, the effects of high-pressure treatment on structure and allergeincity of alpha amylase inhibitor (a-AI) were investigated. The pressure-induced structural changes of α-AI were estimated by fluorescence spectra and by fourth derivative UV-spectroscopy for probed tyrosine residues and by circular dichroism (CD) spectroscopy. The changes in the tertiary structure detected by fluorescence spectra and by fourth derivative UV-spectroscopy under high pressure were indicated at over 300 MPa. Measurements of CD spectroscopy suggested that the effects of a high-pressure treatment on changes in the secondary structure of α-AI were little. From our results, pressure-induced changes of the α-AI structure were not apparent. On the other hands, the IgE-specific binding activities of pressurized α-AI to sera from allergic patients against wheat, which is estimated by observations of dot-blotting, were decreased by high-pressure treatment. It is known that the pressure-induced elimination of allergenicity is related to the tertiary structural changes of allergen molecules. This study are suspected that the epitopes of α-AI do not contain tyrosine residues, and thus the decrease of IgE-specific binding activities is probably caused by the tertiary structural changes of these parts of α-AI.

  1. Effects of a high-pressure treatment on the wheat alpha-amylase inhibitor and its relationship to elimination of allergenicity

    International Nuclear Information System (INIS)

    Yamamoto, S; Takanohashi, K; Nishiumi, T; Hara, T; Odani, S; Suzuki, A

    2010-01-01

    In this study, the effects of high-pressure treatment on structure and allergeincity of alpha amylase inhibitor (a-AI) were investigated. The pressure-induced structural changes of α-AI were estimated by fluorescence spectra and by fourth derivative UV-spectroscopy for probed tyrosine residues and by circular dichroism (CD) spectroscopy. The changes in the tertiary structure detected by fluorescence spectra and by fourth derivative UV-spectroscopy under high pressure were indicated at over 300 MPa. Measurements of CD spectroscopy suggested that the effects of a high-pressure treatment on changes in the secondary structure of α-AI were little. From our results, pressure-induced changes of the α-AI structure were not apparent. On the other hands, the IgE-specific binding activities of pressurized α-AI to sera from allergic patients against wheat, which is estimated by observations of dot-blotting, were decreased by high-pressure treatment. It is known that the pressure-induced elimination of allergenicity is related to the tertiary structural changes of allergen molecules. This study are suspected that the epitopes of α-AI do not contain tyrosine residues, and thus the decrease of IgE-specific binding activities is probably caused by the tertiary structural changes of these parts of α-AI.

  2. Network Efficiency and Posterior Alpha Patterns Are Markers of Recovery from General Anesthesia: A High-Density Electroencephalography Study in Healthy Volunteers

    Directory of Open Access Journals (Sweden)

    Stefanie Blain-Moraes

    2017-06-01

    Full Text Available Recent studies have investigated local oscillations, long-range connectivity, and global network patterns to identify neural changes associated with anesthetic-induced unconsciousness. These studies typically employ anesthetic protocols that either just cross the threshold of unconsciousness, or induce deep unconsciousness for a brief period of time—neither of which models general anesthesia for major surgery. To study neural patterns of unconsciousness and recovery in a clinically-relevant context, we used a realistic anesthetic regimen to induce and maintain unconsciousness in eight healthy participants for 3 h. High-density electroencephalogram (EEG was acquired throughout and for another 3 h after emergence. Seven epochs of 5-min eyes-closed resting states were extracted from the data at baseline as well as 30, 60, 90, 120, 150, and 180-min post-emergence. Additionally, 5-min epochs were extracted during induction, unconsciousness, and immediately prior to recovery of consciousness, for a total of 10 analysis epochs. The EEG data in each epoch were analyzed using source-localized spectral analysis, phase-lag index, and graph theoretical techniques. Posterior alpha power was significantly depressed during unconsciousness, and gradually approached baseline levels over the 3 h recovery period. Phase-lag index did not distinguish between states of consciousness or stages of recovery. Network efficiency was significantly depressed and network clustering coefficient was significantly increased during unconsciousness; these graph theoretical measures returned to baseline during the 3 h recovery period. Posterior alpha power may be a potential biomarker for normal recovery of functional brain networks after general anesthesia.

  3. Hard alpha-keratin degradation inside a tissue under high flux X-ray synchrotron micro-beam: a multi-scale time-resolved study.

    Science.gov (United States)

    Leccia, Emilie; Gourrier, Aurélien; Doucet, Jean; Briki, Fatma

    2010-04-01

    X-rays interact strongly with biological organisms. Synchrotron radiation sources deliver very intense X-ray photon fluxes within micro- or submicro cross-section beams, resulting in doses larger than the MGy. The relevance of synchrotron radiation analyses of biological materials is therefore questionable since such doses, million times higher than the ones used in radiotherapy, can cause huge damages in tissues, with regard to not only DNA, but also proteic and lipid organizations. Very few data concerning the effect of very high X-ray doses in tissues are available in the literature. We present here an analysis of the structural phenomena which occur when the model tissue of human hair is irradiated by a synchrotron X-ray micro-beam. The choice of hair is supported by its hierarchical and partially ordered keratin structure which can be analysed inside the tissue by X-ray diffraction. To assess the damages caused by hard X-ray micro-beams (1 microm(2) cross-section), short exposure time scattering SAXS/WAXS patterns have been recorded at beamline ID13 (ESRF) after various irradiation times. Various modifications of the scattering patterns are observed, they provide fine insight of the radiation damages at various hierarchical levels and also unexpectedly provide information about the stability of the various hierarchical structural levels. It appears that the molecular level, i.e. the alpha helices which are stabilized by hydrogen bonds and the alpha-helical coiled coils which are stabilized by hydrophobic interactions, is more sensitive to radiation than the supramolecular architecture of the keratin filament and the filament packing within the keratin associated proteins matrix, which is stabilized by disulphide bonds. (c) 2009 Elsevier Inc. All rights reserved.

  4. A highly conserved phenylalanine in the alpha, beta-T cell receptor (TCR) constant region determines the integrity of TCR/CD3 complexes

    DEFF Research Database (Denmark)

    Caspar-Bauguil, S; Arnaud, J; Huchenq, A

    1994-01-01

    In the present study, we have investigated the importance of a phenylalanine (phe195) in the Tcr-C alpha region on Tcr-alpha,beta/CD3 membrane expression. An exchange of phe195 with a tyrosine residue does not affect Tcr/CD3 membrane expression; however, exchange with aspartic acid, histidine or ...

  5. Conference summaries

    International Nuclear Information System (INIS)

    Phillips, G.J.

    1985-01-01

    The 113 papers presented at this conference covered the areas of 1) fuel design, development and production; 2) nuclear plant safety; 3) nuclear instrumentation; 4) public and regulatory matters; 5) developments and opportunities in fusion; 6) fuel behaviour under normal operating conditions; 7) nuclear plant design and operations; 8) materials science and technology; 9) nuclear power issues; 10) fusion technology; 11) fuel behaviour under accident conditions; 12) large scale fuel channel replacement programs; 13) thermalhydraulics experimental studies; 14) reactor physics and analysis; 15) applications of accelerators; 16) fission product release and severe fuel damage under accident conditions; 17) thermalhydraulics modeling and assessments; 18) waste management and the environment; and 20) new reactor concepts

  6. NATO Conference

    CERN Document Server

    Lynn, W

    1975-01-01

    The contents of this volume involve selection, emendation and up-dating of papers presented at the NATO Conference "Mathe­ matical Analysis of Decision problems in Ecology" in Istanbul, Turkey, July 9-13, 1973. It was sponsored by the System Sciences Division of NATO directed by Dr. B. Bayraktar with local arrange­ ments administered by Dr. Ilhami Karayalcin, professor of the Department of Industrial Engineering at the Technical University of Istanbul. It was organized by A. Charnes, University professor across the University of Texas System, and Walter R.Lynn, Di­ rector of the School of Civil and Environmental Engineering at Cornell Unjversity. The objective of the conference was to bring together a group of leading researchers from the major sciences involved in eco­ logical problems and to present the current state of progress in research of a mathematical nature which might assist in the solu­ tion of these problems. Although their presentations are not herein recorded, the key­ note address of Dr....

  7. EGC Conferences

    CERN Document Server

    Ritschard, Gilbert; Pinaud, Bruno; Venturini, Gilles; Zighed, Djamel; Advances in Knowledge Discovery and Management

    This book is a collection of representative and novel works done in Data Mining, Knowledge Discovery, Clustering and Classification that were originally presented in French at the EGC'2012 Conference held in Bordeaux, France, on January 2012. This conference was the 12th edition of this event, which takes place each year and which is now successful and well-known in the French-speaking community. This community was structured in 2003 by the foundation of the French-speaking EGC society (EGC in French stands for ``Extraction et Gestion des Connaissances'' and means ``Knowledge Discovery and Management'', or KDM). This book is intended to be read by all researchers interested in these fields, including PhD or MSc students, and researchers from public or private laboratories. It concerns both theoretical and practical aspects of KDM. The book is structured in two parts called ``Knowledge Discovery and Data Mining'' and ``Classification and Feature Extraction or Selection''. The first part (6 chapters) deals with...

  8. Workshop on Precision Measurements of $\\alpha_s$

    Energy Technology Data Exchange (ETDEWEB)

    Bethke, Siegfried; /Munich, Max Planck Inst.; Hoang, Andre H.; /Vienna U.; Kluth, Stefan; /Munich, Max Planck Inst.; Schieck, Jochen; /Munich U.; Stewart, Iain W.; Aoki, S.; Beneke, M.; Bethke, S.; Blumlein, J.; Brambilla, N.; Brodsky, S.; /MIT, LNS

    2011-10-01

    These are the proceedings of the Workshop on Precision Measurements of {alpha}{sub s} held at the Max-Planck-Institute for Physics, Munich, February 9-11, 2011. The workshop explored in depth the determination of {alpha}{sub s}(m{sub Z}) in the {ovr MS} scheme from the key categories where high precision measurements are currently being made, including DIS and global PDF fits, {tau}-decays, electro-weak precision observables and Z-decays, event-shapes, and lattice QCD. These proceedings contain a short summary contribution from the speakers, as well as the lists of authors, conveners, participants, and talks.

  9. Drugs interacting with alpha adrenoceptors

    NARCIS (Netherlands)

    van Zwieten, P. A.

    1989-01-01

    Alpha adrenoceptors should be divided into various subtypes, comprising pre/postsynaptic and alpha 1/alpha 2-subpopulations, respectively. This classification implicates important functional differences between the various alpha-receptor subtypes, including certain differences in signal transduction

  10. Structured intermittent interruption of chronic HIV infection treatment with highly active antiretroviral therapy: effects on leptin and TNF-alpha.

    Science.gov (United States)

    Arjona, M Montes de Oca; Pérez-Cano, R; Garcia-Juárez, R; Martín-Aspas, A; del Alamo, C Fernández Gutiérrez; Girón-González, J A

    2006-04-01

    The changes in nutritional parameters and adipocytokines after structured intermittent interruption of highly active antiretroviral treatment of patients with chronic HIV infection are analyzed. Twenty-seven patients with chronic HIV infection (median CD4+ T cell count/microl: nadir, 394; at the beginning of structured interruptions, 1041; HIV viral load: nadir, 41,521 copies/ml; at the beginning of structured interruptions triglycerides, cholesterol, leptin, and tumor necrosis factor and its soluble receptors I and II were determined. After the three cycles of intermittent interruptions of therapy, no significant differences in CD4+ T cell count/microl, viral load, or serum concentrations of cholesterol or triglycerides with reference to baseline values were found. A near-significant higher fatty mass (skinfold thicknesses, at the end, 121 mm, at the beginning, 100 mm, p = 0.100), combined with a significant increase of concentration of leptin (1.5 vs. 4.7 ng/ml, p = 0,044), as well as a decrease in serum concentrations of soluble receptors of tumor necrosis factor (TNFRI, 104 vs. 73 pg/ml, p = 0.022; TNFRII 253 vs. 195 pg/ml, p = 0.098) were detected. Structured intermittent interruption of highly active antiretroviral treatment of patients with chronic HIV infection induces a valuable positive modification in markers of lipid turnover and adipose tissue mass.

  11. Title - EFARS - Conference (Uninvited)

    OpenAIRE

    Lohrey, MC; Lawrence, AS

    2016-01-01

    Abstract - EFARS - Conference (Uninvited) "Notes" - EFARS - Conference (Uninvited) In preparation (Publication status) Yes, full paperYes, abstract onlyNo (Peer reviewed?) "Add a comment" - EFARS - Conference - Uninvited

  12. Gold nanoparticle labeling with tyramide signal amplification for highly sensitive detection of alpha fetoprotein in human serum by ICP-MS.

    Science.gov (United States)

    Li, Xiaoting; Chen, Beibei; He, Man; Xiao, Guangyang; Hu, Bin

    2018-01-01

    In this work, we developed an immunoassay based on tyramide signal amplification (TSA) and gold nanoparticles (Au NPs) labeling for highly sensitive detection of alpha fetoprotein (AFP) by inductively coupled plasma mass spectrometry (ICP-MS). AFP was captured by anti-AFP1 coating on the 96-well plate and labeled by anti-AFP2-horseradish peroxidase (HRP), in which the HRP can catalyze the deposition of biotinylated tyramine on the nearby protein. Then the streptavidin (SA)-Au NPs was labeled on the deposited biotinylated tyramine as the intensive signal probe for ICP-MS measurement. Under the optimal experimental conditions, the limit of detection of the developed method for AFP was 1.85pg/mL and the linear range was 0.005-2ng/mL. The relative standard deviation for seven replicate detections of 0.01ng/mL AFP was 5.2%. The proposed method was successfully applied to the detection of AFP in human serum with good recoveries. This strategy is highly sensitive and easy to operate, and can be extended to the sensitive detection of other biomolecules in human serum. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. International Conference on Cosmic Rays

    CERN Multimedia

    W.O. LOCK

    1964-01-01

    Towards the end of last year the 8th International conference on cosmic rays, held under the auspices of the International Union of Pure and Applied Physics (I.U.P.A.P.) and the Department of Atomic Energy of the Government of India, was held at Jaipur, India. Among the participants was W.O. Lock, head of CERN's Emulsion Group, who gave an invited talk on recent work in the field of what is normally known as high-energy physics — though in the context of this conference such energies seem quite low. In this article, Dr. Lock gives a general review of the conference and of the subjects discussed.

  14. Peroxidation of the dried thin film of lipid by high-energy alpha particles from a cyclotron

    International Nuclear Information System (INIS)

    Agarwal, S.; Chatterjee, S.N.

    1984-01-01

    High-energy α particles produced a dose-dependent linear increase in different lipid peroxidation products (e.g., malondialdehyde (MDA), conjugated dienes, and hydroperoxides) in the dried thin film state. An inverse dose-rate effect was observed when the dose rate was varied by changing either the α-particle fluence rate or the α-particle energy. The antioxidants α-tocopherol and butylated hydroxytoluene (BHT) suppressed the α-particle-induced lipid peroxidation in the dried thin film state, and in this respect α-tocopherol was found superior to BHT. It was found that α-tocopherol was equally efficient in inhibiting lipid peroxidations by α particles and ultraviolet light

  15. Radiological protection issues during primary filter housing replacement in a high alpha, beta-gamma shielded facility at Dounreay

    International Nuclear Information System (INIS)

    Mowat, D.; Watkin, T.

    2006-01-01

    Dounreay, on the north coast of Scotland, was home to the United Kingdom Fast Breeder Reactor (F.B.R.) development programme. F.B.R. use excess, non-moderated ('fast') neutrons to convert (breed) uranium, in elements positioned at the outer edges of the reactor core, into plutonium which can then be used as fuel.Site construction began in 1955 and three reactors were built and operated; the Dounreay Materials Test Reactor (D.M.T.R.) 1958-1969, the Dounreay Fast Reactor (D.F.R.) 1959-1977 and the Prototype Fast Reactor (P.F.R.) 1974-1994. The D.F.R. was conventionally fuelled by highly enriched uranium whereas the P.F.R. used a ceramic form of plutonium oxide (PuO 2 ) as its fuel. Dounreay was almost entirely self-sufficient in that a fuel cycle (chemical reprocessing) area was constructed complete with recovery plants, laboratories, waste storage and other support services buildings. Liquid plutonium nitrate product was sent to Sellafield, in Cumbria, to convert for future use, and the fuel elements were then fabricated at Springfields. Eventually, recovered P.F.R. plutonium was loaded back into the reactor, closing the fuel cycle. As a matter of interest for this paper, a Post Irradiation Examination (P.I.E.) facility, D2001, was built in the early 1960' s. The Plant was equipped with a suite of ten north and south side cells built to a high level of containment within which irradiated P.F.R. fuel could be remotely disassembled and examined. This work supported the continuing development of F.B.R. design and technology and the Plant has operated very successfully throughout its lifetime. A programme of improvement was implemented to enhance reliability, productivity and to modernize the facility to meet current nuclear and engineering standards. The experience of this work is detailed in this paper. (N.C.)

  16. Conference Proceedings

    International Nuclear Information System (INIS)

    2002-01-01

    This volume contains the unedited proceedings of the Second Annual Conference on Managing Electricity Price Volatility. There were a total of eleven papers presented, dealing with a variety of issues affecting price volatility. Subjects treated included: new power generation development in Alberta; an analysis of electricity supply and demand to predict future price volatility; the effect of government intervention in the Alberta electricity market; risk management in volatile energy markets; an analysis of Alberta's capacity to supply its own internal electric power needs; the impact of increased electricity import and export capacity on price fluctuation in Alberta; improving market liquidity in Alberta; using weather derivatives to offset price risk; the impact of natural gas prices on electricity price volatility; capitalizing on advancements in online trading; and strategies for businesses to keep operating through times of price volatility. In most cases only overhead viewgraphs are available

  17. MUSME Conference

    CERN Document Server

    Martinez, Eusebio

    2015-01-01

    This volume contains the Proceedings of MUSME 2014, held at Huatulco in Oaxaca, Mexico, October 2014. Topics include analysis and synthesis of mechanisms; dynamics of multibody systems; design algorithms for mechatronic systems; simulation procedures and results; prototypes and their performance; robots and micromachines; experimental validations; theory of mechatronic simulation; mechatronic systems; and control of mechatronic systems. The MUSME symposium on Multibody Systems and Mechatronics was held under the auspices of IFToMM, the International Federation for Promotion of Mechanism and Machine Science, and FeIbIM, the Iberoamerican Federation of Mechanical Engineering. Since the first symposium in 2002, MUSME events have been characterised by the way they stimulate the integration between the various mechatronics and multibody systems dynamics disciplines, present a forum for facilitating contacts among researchers and students mainly in South American countries, and serve as a joint conference for the ...

  18. Cairo conference.

    Science.gov (United States)

    McMichael, A J

    1994-09-03

    The United Nations Conference on Population and Development in Cairo in September, 1994, will evoke criticism of the inability of governments to act quickly enough to avert demographic and environmental crises. Rapid population growth has clear implications for public health. Globally there now occur anthropogenic changes in atmospheric composition, the degradation of fertile lands and ocean fisheries, an accelerating loss of biodiversity, and the social and ecological problems of massive urbanization. In the future, per capita consumption levels will increase in burgeoning populations of developing countries, thus adding to the environmental impacts of overconsuming rich countries. By the end of the decade there will be over six billion people, of whom one half will live in cities. These demographic and environmental trends, if translated into climatic change, regional food shortages, and weakened ecosystems, would adversely affect human health. The World Health Organization is likely to concentrate only on accessible family planning and promotion of health for women and families. Continuing asymmetric child-saving aid, unaccompanied by substantial aid to help mobilize the social and economic resources needed to reduce fertility, may delay the demographic transition in poor countries and potentiate future public health disasters. As a result of recent reductions in fertility, even in Sub-Saharan Africa, average family sizes have been halved. Yet the demographic momentum will double population by 2050. The biosphere is a complex of ecosystems and, if unsustained, it could not fulfill the productive, cleansing, and protective functions on which life depends. The Cairo conference must therefore recognize that sustaining human health is a prime reason for concern about population growth and models of economic development.

  19. Space Station alpha joint bearing

    Science.gov (United States)

    Everman, Michael R.; Jones, P. Alan; Spencer, Porter A.

    1987-01-01

    Perhaps the most critical structural system aboard the Space Station is the Solar Alpha Rotary Joint which helps align the power generation system with the sun. The joint must provide structural support and controlled rotation to the outboard transverse booms as well as power and data transfer across the joint. The Solar Alpha Rotary Joint is composed of two transition sections and an integral, large diameter bearing. Alpha joint bearing design presents a particularly interesting problem because of its large size and need for high reliability, stiffness, and on orbit maintability. The discrete roller bearing developed is a novel refinement to cam follower technology. It offers thermal compensation and ease of on-orbit maintenance that are not found in conventional rolling element bearings. How the bearing design evolved is summarized. Driving requirements are reviewed, alternative concepts assessed, and the selected design is described.

  20. Source preparation in alpha spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lally, A E [UKAEA Atomic Energy Research Establishment, Harwell. Environmental and Medical Sciences Div.; Glover, K M [UKAEA Atomic Energy Research Establishment, Harwell. Chemistry Div.

    1984-06-15

    Techniques, for the preparation of sources suitable for alpha spectrometric measurements are presented. These include vacuum sublimation, electrodeposition, self-deposition, direct evaporation, direct precipitation and the use of solvents and spreading agents. The relative merits of each technique and the applicability to both high and low levels of activity are considered.

  1. Vancouver Accelerator Conference

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1985-06-15

    Anyone who contends that particle physics is conducted in an ivory tower, not contributing to other fields of science or to humanity at large, should have attended the 1985 Particle Accelerator Conference in Vancouver. Over a thousand participants contributed 781 papers and only a fraction were actually related to accelerators for high energy physics. The majority of present developments are in the service of other fields of science, for alternative power sources, for medicine, for industrial applications, etc.

  2. Computing Conference at Bologna

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    From 9-12 September a Europhysics Conference on Computing in High Energy and Nuclear Physics, organized by the Computational Physics Group of the European Physical Society, was held in Bologna, attracting some 150 participants. Its purpose was contact and exchange of information between experimental physicists (from both fields of research) and computer experts (on whom the successful outcome of the research has become increasingly dependent)

  3. Vancouver Accelerator Conference

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    Anyone who contends that particle physics is conducted in an ivory tower, not contributing to other fields of science or to humanity at large, should have attended the 1985 Particle Accelerator Conference in Vancouver. Over a thousand participants contributed 781 papers and only a fraction were actually related to accelerators for high energy physics. The majority of present developments are in the service of other fields of science, for alternative power sources, for medicine, for industrial applications, etc

  4. A Molecular dynamics study of helium bubble stability during high-energy displacement cascades in alpha-iron

    International Nuclear Information System (INIS)

    Pu, Jin; Yang, Li; Zu, Xiaotao; Gao, Fei

    2007-01-01

    The interactions of high-energy displacement cascades with helium bubbles in a-Fe are investigated using molecular dynamics simulations. Initial bubbles with the volumes of 212 and 636 (angstrom)3 are considered, and the helium-to-vacancy (He/V) ratio in the bubbles varies from 0.5 to 3. Primary knock-on atom (PKA) energy, Ep, is up to 40 keV. The results show that the change of nm-sized He bubbles due to displacement cascade does not depend much on the bubble size, but rather on the He/V ratio and the recoil energy. For the initial He/V ratio less than 1, the size of the bubbles decreases with increasing PKA energy, but the He/V ratio increases. However, for the initial He/V ratio of 3, the size of the bubbles increases, and the He/V ratio decreases with PKA energy. For the initial He/V ratio of 1, the ratio of the small bubble decreases slightly, but the ratio of the large bubble remains unchanged for lower PKA energy, and increases slightly for higher PKA energy. The reasons for these observed phenomena have been explained

  5. Conference on instrumental activation analysis IAA 86

    International Nuclear Information System (INIS)

    Vobecky, M.; Obrusnik, I.

    1986-04-01

    Thirty five papers were presented at the conference held in Klucenice, Czechoslovakia from May 4 to 8, 1986. The abstracts of all papers are printed in the proceedings. The conference discussed the following problem areas: the application of activation analysis in determining elements in ores, tectites, fungi, the thyroid, the primary circuit coolant, semiconductor materials; the application of nuclear reaction analysis in determining elements in rubber and coal; the application of tracer techniques in metallurgy; the description of alpha and gamma spectrometric systems and their testing; the use of microcomputers for data processing, and the description of programs. (J.P.)

  6. Synthesis, X-ray structure, and hydrolytic chemistry of the high potent antiviral polyniobotungstate A-[alpha]-[Si2Nb6W18O77]8–

    Science.gov (United States)

    Gyu-Shik Kim; Huadong Zeng; Jeffrey T. Rhule; Ira A. Weinstock; Craig L. Hill

    1999-01-01

    Potently antiviral polyniobotungstates have been structurally characterized; the dimer A-[alpha]-[Si2Nb6W18O77]8– cleaves cleanly to the monomer A-[alpha]-[SiNb3W9O40]7– within 1 min in aqueous solution buffered at physiological (neutral) pH establishing that the monomer and not the dimer is pharmacologically relevant.

  7. Expression of NgBR Is Highly Associated with Estrogen Receptor Alpha and Survivin in Breast Cancer

    Science.gov (United States)

    North, Paula; Kong, Amanda; Huang, Jian; Miao, Qing Robert

    2013-01-01

    NgBR is a type I receptor with a single transmembrane domain and was identified as a specific receptor for Nogo-B. Our recent findings demonstrated that NgBR binds farnesylated Ras and recruits Ras to the plasma membrane, which is a critical step required for the activation of Ras signaling in human breast cancer cells and tumorigenesis. Here, we first use immunohistochemistry and real-time PCR approaches to examine the expression patterns of Nogo-B and NgBR in both normal and breast tumor tissues. Then, we examine the relationship between NgBR expression and molecular subtypes of breast cancer, and the roles of NgBR in estrogen-dependent survivin signaling pathway. Results showed that NgBR and Nogo-B protein were detected in both normal and breast tumor tissues. However, the expression of Nogo-B and NgBR in breast tumor tissue was much stronger than in normal breast tissue. The statistical analysis demonstrated that NgBR is highly associated with ER-positive/HER2-negative breast cancer. We also found that the expression of NgBR has a strong correlation with the expression of survivin, which is a well-known apoptosis inhibitor. The correlation between NgBR and survivin gene expression was further confirmed by real-time PCR. In vitro results also demonstrated that estradiol induces the expression of survivin in ER-positive T47D breast tumor cells but not in ER-negative MDA-MB-468 breast tumor cells. NgBR knockdown with siRNA abolishes estradiol-induced survivin expression in ER-positive T47D cells but not in ER-negative MDA-MB-468 cells. In addition, estradiol increases the expression of survivin and cell growth in ER-positive MCF-7 and T47D cells whereas knockdown of NgBR with siRNA reduces estradiol-induced survivin expression and cell growth. In summary, these results indicate that NgBR is a new molecular marker for breast cancer. The data suggest that the expression of NgBR may be essential in promoting ER-positive tumor cell proliferation via survivin induction

  8. Identification of high-mannose and multiantennary complex-type N-linked glycans containing alpha-galactose epitopes from Nurse shark IgM heavy chain.

    Science.gov (United States)

    Harvey, David J; Crispin, Max; Moffatt, Beryl E; Smith, Sylvia L; Sim, Robert B; Rudd, Pauline M; Dwek, Raymond A

    2009-11-01

    MALDI-TOF mass spectrometry, negative ion nano-electrospray MS/MS and exoglycosidase digestion were used to identify 36 N-linked glycans from 19S IgM heavy chain derived from the nurse shark (Ginglymostoma cirratum). The major glycan was the high-mannose compound, Man(6)GlcNAc(2) accompanied by small amounts of Man(5)GlcNAc(2), Man(7)GlcNAc(2) and Man(8)GlcNAc(2). Bi- and tri-antennary (isomer with a branched 3-antenna) complex-type glycans were also abundant, most contained a bisecting GlcNAc residue (beta1-->4-linked to the central mannose) and with varying numbers of alpha-galactose residues capping the antennae. Small amounts of monosialylated glycans were also found. This appears to be the first comprehensive study of glycosylation in this species of animal. The glycosylation pattern has implications for the mechanism of activation of the complement system by nurse shark IgM.

  9. Detection and Estimation of alpha-Amyrin, beta-Sitosterol, Lupeol, and n-Triacontane in Two Medicinal Plants by High Performance Thin Layer Chromatography

    Directory of Open Access Journals (Sweden)

    Saikat S. Mallick

    2014-01-01

    Full Text Available A normal phase high performance thin layer chromatography (HPTLC method has been developed and validated for simultaneous estimation of four components, namely, alpha-amyrin, beta-sitosterol, lupeol, and n-triacontane from two medicinally important plants, Leptadenia reticulata Wight & Arn. and Pluchea lanceolata (DC. CB. Clarke. In Ayurveda, both plants have been reported to possess immunomodulatory activity. Chromatographic separation of the four components from the methanolic extracts of whole plant powders of Leptadenia reticulata Wight & Arn. and Pluchea lanceolata (DC. CB. Clarke. was performed on TLC aluminium plates precoated with silica gel 60F254 using a suitable mobile phase. The densitometric scanning was done after derivatization at λ = 580 nm for α-amyrin, β-sitosterol, and lupeol, and at 366 nm for n-triacontane. The developed HPTLC method has been validated and used for simultaneous quantitation of the four components from the methanolic extracts of whole plant powders of Leptadenia reticulata Wight & Arn. and Pluchea lanceolata (DC. CB. Clarke. The developed HPTLC method is simple, rapid, and precise and can be used for routine quality control.

  10. 16 alpha-[77Br]bromoestradiol-17 beta: a high specific-activity, gamma-emitting tracer with uptake in rat uterus and uterus and induced mammary tumors

    International Nuclear Information System (INIS)

    Katzenellenbogen, J.A.; Senderoff, S.G.; McElvany, K.D.; O'Brien, H.A. Jr.; Welch, M.J.

    1981-01-01

    16 alpha-[77Br]bromoestradiol-17 beta (Compound 1) has been synthesized by radiobromination of estrone enoldiacetate. Tissue uptake studies performed 1 h after administration of Compound 1 to immature or mature female rats showed uterus-to-blood ratios of 13, with nontarget issue-to-blood ratios ranging from 0.6 to 2. Co-administration of unlabelled estradiol caused a selective depression in the uterine uptake with no effect on nontarget tissue uptake. In adult animals bearing adenocarcinomas induced by DMBA (7,12-dimethylbenz(a)anthracene), tumor-to-blood ratios of 6.3 were obtained, this uptake also being depressed in animals treated with unlabeled estradiol. The studies demonstrate that Compound 1 has suitable binding properties and sufficiently high specific activity so that its uptake in estrogen target tissues in vivo is mediated primarily by the estrogen receptor. Furthermore, they suggest that this compound may be suitable for imaging human breast tumors that contain estrogen receptors

  11. Identification of regulated genes conferring resistance to high concentrations of glyphosate in a new strain of Enterobacter.

    Science.gov (United States)

    Fei, Yun-Yan; Gai, Jun-Yi; Zhao, Tuan-Jie

    2013-12-01

    Glyphosate is a widely used herbicide that inhibits 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity. Most plants and microbes are sensitive to glyphosate. However, transgenic-resistant crops that contain a modified epsps obtained from the resistant microbes have been commercially successful and therefore, new resistance genes and their adaptive regulatory mechanisms are of great interest. In this study, a soil-borne, glyphosate-resistant bacterium was selected and identified as Enterobacter. The EPSPS in this strain was found to have been altered to a resistant one. A total of 42 differentially expressed genes (DEGs) in the glyphosate were screened using microarray techniques. Under treatment, argF, sdhA, ivbL, rrfA-H were downregulated, whereas the transcripts of speA, osmY, pflB, ahpC, fusA, deoA, uxaC, rpoD and a few ribosomal protein genes were upregulated. Data were verified by quantitative real-time PCR on selected genes. All transcriptional changes appeared to protect the bacteria from glyphosate and associated osmotic, acidic and oxidative stresses. Many DEGs may have the potential to confer resistance to glyphosate alone, and some may be closely related to the shikimate pathway, reflecting the complex gene interaction network for glyphosate resistance. © 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

  12. New ALPHA-2 magnet

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    On 21 June, members of the ALPHA collaboration celebrated the handover of the first solenoid designed for the ALPHA-2 experiment. The magnet has since been successfully installed and is working well.   Khalid Mansoor, Sumera Yamin and Jeffrey Hangst in front of the new ALPHA-2 solenoid. “This was the first of three identical solenoids that will be installed between now and September, as the rest of the ALPHA-2 device is installed and commissioned,” explains ALPHA spokesperson Jeffrey Hangst. “These magnets are designed to allow us to transfer particles - antiprotons, electrons and positrons - between various parts of the new ALPHA-2 device by controlling the transverse size of the particle bunch that is being transferred.” Sumera Yamin and Khalid Mansoor, two Pakistani scientists from the National Centre for Physics in Islamabad, came to CERN in February specifically to design and manufacture these magnets. “We had the chance to work on act...

  13. Oleic acid and peanut oil high in oleic acid reverse the inhibitory effect of insulin production of the inflammatory cytokine TNF-alpha both in vitro and in vivo systems.

    Science.gov (United States)

    Vassiliou, Evros K; Gonzalez, Andres; Garcia, Carlos; Tadros, James H; Chakraborty, Goutam; Toney, Jeffrey H

    2009-06-26

    Chronic inflammation is a key player in pathogenesis. The inflammatory cytokine, tumor necrosis factor-alpha is a well known inflammatory protein, and has been a therapeutic target for the treatment of diseases such as Rheumatoid Arthritis and Crohn's Disease. Obesity is a well known risk factor for developing non-insulin dependent diabetes melitus. Adipose tissue has been shown to produce tumor necrosis factor-alpha, which has the ability to reduce insulin secretion and induce insulin resistance. Based on these observations, we sought to investigate the impact of unsaturated fatty acids such as oleic acid in the presence of TNF-alpha in terms of insulin production, the molecular mechanisms involved and the in vivo effect of a diet high in oleic acid on a mouse model of type II diabetes, KKAy. The rat pancreatic beta cell line INS-1 was used as a cell biological model since it exhibits glucose dependent insulin secretion. Insulin production assessment was carried out using enzyme linked immunosorbent assay and cAMP quantification with competitive ELISA. Viability of TNF-alpha and oleic acid treated cells was evaluated using flow cytometry. PPAR-gamma translocation was assessed using a PPRE based ELISA system. In vivo studies were carried out on adult male KKAy mice and glucose levels were measured with a glucometer. Oleic acid and peanut oil high in oleic acid were able to enhance insulin production in INS-1. TNF-alpha inhibited insulin production but pre-treatment with oleic acid reversed this inhibitory effect. The viability status of INS-1 cells treated with TNF-alpha and oleic acid was not affected. Translocation of the peroxisome proliferator- activated receptor transcription factor to the nucleus was elevated in oleic acid treated cells. Finally, type II diabetic mice that were administered a high oleic acid diet derived from peanut oil, had decreased glucose levels compared to animals administered a high fat diet with no oleic acid. Oleic acid was found to

  14. Report on the Taipei CHEP 2010 Conference

    CERN Multimedia

    CERN. Geneva

    2010-01-01

    This year, the 18th Computing in High Energy and Nuclear Physics (CHEP) conference has been held at Taipei, Taiwan, from 18-22 October 2010.CHEP conferences provide an international forum to exchange information on computing experience and needs for the High Energy Physics and Nuclear Physics communities, and to review recent, ongoing and future activities.The speakers at this Computing Seminar will present their views of the CHEP 2010 conference.

  15. Metabolic Engineering VII Conference

    Energy Technology Data Exchange (ETDEWEB)

    Kevin Korpics

    2012-12-04

    The aims of this Metabolic Engineering conference are to provide a forum for academic and industrial researchers in the field; to bring together the different scientific disciplines that contribute to the design, analysis and optimization of metabolic pathways; and to explore the role of Metabolic Engineering in the areas of health and sustainability. Presentations, both written and oral, panel discussions, and workshops will focus on both applications and techniques used for pathway engineering. Various applications including bioenergy, industrial chemicals and materials, drug targets, health, agriculture, and nutrition will be discussed. Workshops focused on technology development for mathematical and experimental techniques important for metabolic engineering applications will be held for more in depth discussion. This 2008 meeting will celebrate our conference tradition of high quality and relevance to both industrial and academic participants, with topics ranging from the frontiers of fundamental science to the practical aspects of metabolic engineering.

  16. Alpha Shapes and Proteins

    DEFF Research Database (Denmark)

    Winter, Pawel; Sterner, Henrik; Sterner, Peter

    2009-01-01

    We provide a unified description of (weighted) alpha shapes, beta shapes and the corresponding simplicialcomplexes. We discuss their applicability to various protein-related problems. We also discuss filtrations of alpha shapes and touch upon related persistence issues.We claim that the full...... potential of alpha-shapes and related geometrical constructs in protein-related problems yet remains to be realized and verified. We suggest parallel algorithms for (weighted) alpha shapes, and we argue that future use of filtrations and kinetic variants for larger proteins will need such implementation....

  17. 18th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2014-01-01

    Cryocoolers 18 Cryocoolers 18 archives developments and performance measurements in the field of cryocoolers based on the contributions of leading international experts at the 18th International Cryocooler Conference that was held in Syracuse, New York, on June 9-12, 2014. The program of this conference lead to the 76 peer-reviewed papers that are published here. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  18. PREFACE: Quark Matter 2006 Conference

    Science.gov (United States)

    Ma, Yu-Gang; Wang, En-Ke; Cai, Xu; Huang, Huan-Zhong; Wang, Xin-Nian; Zhu, Zhi-Yuan

    2007-07-01

    The Quark Matter 2006 conference was held on 14 20 November 2006 at the Shanghai Science Hall of the Shanghai Association of Sciences and Technology in Shanghai, China. It was the 19th International Conference on Ultra-Relativistic Nucleus Nucleus Collisions. The conference was organized jointly by SINAP (Shanghai Institute of Applied Physics, Chinese Academy of Sciences (CAS)) and CCNU (Central China Normal University, Wuhan). Over 600 scientists from 32 countries in five continents attended the conference. This is the first time that China has hosted such a premier conference in the field of relativistic heavy-ion collisions, an important event for the Chinese high energy nuclear physics community. About one half of the conference participants are junior scientists—a clear indication of the vigor and momentum for this field, in search of the fundamental nature of the nuclear matter at extreme conditions. Professor T D Lee, honorary chair of the conference and one of the founders of the quark matter research, delivered an opening address with his profound and philosophical remarks on the recent discovery of the nature of strongly-interacting quark-gluon-plasma (sQGP). Professor Hongjie Xu, director of SINAP, gave a welcome address to all participants on behalf of the two hosting institutions. Dr Peiwen Ji, deputy director of the Mathematics and Physics Division of the Natural Science Foundation of China (NSFC), also addressed the conference participants and congratulated them on the opening of the conference. Professor Mianheng Jiang, vice president of the Chinese Academy of Sciences (CAS), gave a concise introduction about the CAS as the premier research institution in China. He highlighted continued efforts at CAS to foster international collaborations between China and other nations. The Quark Matter 2006 conference is an example of such a successful collaboration between high energy nuclear physicists in China and other nations all over the world. The

  19. Antioxidant profiling of native Andean potato tubers (Solanum tuberosum L.) reveals cultivars with high levels of beta-carotene, alpha-tocopherol, chlorogenic acid, and petanin.

    Science.gov (United States)

    Andre, Christelle M; Oufir, Mouhssin; Guignard, Cédric; Hoffmann, Lucien; Hausman, Jean-François; Evers, Danièle; Larondelle, Yvan

    2007-12-26

    The antioxidant profile of 23 native Andean potato cultivars has been investigated from a human nutrition perspective. The main carotenoid and tocopherol compounds were studied using high-performance liquid chromatography coupled with a diode array detector (HPLC-DAD) and a fluorescence detector, respectively, whereas polyphenols (including anthocyanins in colored tubers) were identified by means of both HPLC-mass spectrometry and HPLC-DAD. Antioxidant profiling revealed significant genotypic variations as well as cultivars of particular interest from a nutritional point of view. Concentrations of the health-promoting carotenoids, lutein and zeaxanthin, ranged from 1.12 to 17.69 microg g(-1) of dry weight (DW) and from 0 to 17.7 microg g(-1) of DW, with cultivars 704353 and 702472 showing the highest levels in lutein and zeaxanthin, respectively. Whereas beta-carotene is rarely reported in potato tubers, remarkable levels of this dietary provitamin A carotenoid were detected in 16 native varieties, ranging from 0.42 to 2.19 microg g(-1) of DW. The amounts of alpha-tocopherol found in Andean potato tubers, extending from 2.73 to 20.80 microg g(-1) of DW, were clearly above the quantities generally reported for commercial varieties. Chlorogenic acid and its isomers dominated the polyphenolic profile of each cultivar. Dark purple-fleshed tubers from the cultivar 704429 contained exceptionally high levels of total anthocyanins (16.33 mg g(-1) of DW). The main anthocyanin was identified as petanin (petunidin-3-p-coumaroyl-rutinoside-5-glucoside). The results suggest that Andean potato cultivars should be exploited in screening and breeding programs for the development of potato varieties with enhanced health and nutritional benefits.

  20. Targeted Alpha Therapy: From Alpha to Omega

    International Nuclear Information System (INIS)

    Allen, Barry J; Clarke, Raymond; Huang Chenyu

    2013-01-01

    This review covers the broad spectrum of Targeted Alpha Therapy (TAT) research in Australia; from in vitro and in vivo studies to clinical trials. The principle of tumour anti-vascular alpha therapy (TAVAT) is discussed in terms of its validation by Monte Carlo calculations of vascular models and the potential role of biological dosimetry is examined. Summmary of this review is as follows: 1. The essence of TAT 2. Therapeutic objectives 3. TAVAT and Monte Carlo microdosimetry 4. Biological dosimetry 5. Preclinical studies 6. Clinical trials 7. What next? 8. Obstacles. (author)

  1. Conference Papers

    International Nuclear Information System (INIS)

    2003-01-01

    A total of 18 papers were presented at the 2003 Annual Executive Conference of the Canadian Gas Association held at St. Andrews, NB, from June 25th to June 28th. Titles of the presentations were as follows: (1) 'Positioning natural gas in a transforming world' by Pierre Marcel Desjardins; (2) 'Positioning natural gas in a transforming world' by Jean-Paul Theoret; (3) 'Perceptions of natural gas' by Noel Sampson; (4) 'Energy efficiency as an opportunity for the natural gas industry' by Peter Love; (5) 'Natural gas R and D - NRCan perspective' by Graham R. Campbell; (6) 'Impact of earned media on corporate perceptions in the gas industry' by Michael Coates; (7) 'Moving forward with an initiative for natural gas technology innovation' by Emmanuel Morin; (8) 'Natural gas R and D - No more dodging the issue' by Chuck Szmurlo; (9) 'Meeting the technology needs of the gas industry and the gas consumer' by Stanley S. Borys; (10) 'Market signals' by John Wellard; (11) 'Future sources of Canadian natural gas' by Rick Hyndman; (12) 'The state of supply: Northeast U.S. perspective' by Tom Kiley; (13) 'AGA's priorities and perspectives' by Dick Reiten; (14) 'Global energy issues: Recent development in policy and business' by Gerald Doucet; (15) 'Keeping the distribution cart behind the horse: Why finding more offshore gas is much more important than completing the natural gas grid, including for New Brunswick' by Brian Lee Crowley; (16) 'Environmental opportunities and challenges for the gas industry' by Manfred Klein; (17) 'The potential for natural gas demand destruction' by Timothy Partridge; and (18) 'Pushing the envelope on gas supply' by Roland R. George. In most instances only speaking notes and view graphs are available

  2. Sterol synthesis. A novel reductive rearrangement of an alpha,beta-unsaturated steroidal epoxide; a new chemical synthesis of 5alpha-cholest-8(14)-en-3beta, 15alpha-diol.

    Science.gov (United States)

    Parish, E J; Schroepfer, G J

    1977-04-01

    Reduction of 3beta-benzoyloxy-14alpha,15alpha-epoxy-5alpha-cholest-7-ene with either lithium triethylboro-hydride or lithium aluminum hydride (4 molar excess) gave 5-alpha-cholest-8(14)-en-3beta,15alpha-diol in high yield. Reduction of the epoxy ester with lithium triethylborodeuteride or lithium aluminum deuteride (4 molar excess) gave [7alpha-2-H]-5alpha-cholest-8(14)-en-3beta,15alpha-diol. Reduction of 2beta-benzoyloxy-14alpha,15alpha-epoxy-5alpha-cholest-7-ene with a large excess (24 molar excess) of lithium aluminum hydride gave, in addition to the expected 5alpha-cholest-8(14)-en-3beta,15alpha-diol, a significant yield (33%) of 5alpha-cholest-8(14)-en-3beta-o1. Reduction of the epoxy ester with a large excess (24 molar excess) of lithium aluminum deuteride gave [7alpha-2H]-5alpha-cholest-8(14)-en-3beta,15alpha-diol and 5alpha-cholest-8(14)-en-3beta-o1 which contained two atoms of stably bound deuterium.

  3. Reverse-phase HPLC analysis of human alpha crystallin.

    Science.gov (United States)

    Swamy, M S; Abraham, E C

    1991-03-01

    A rapid and highly sensitive reverse-phase HPLC (RP-HPLC) method was used to separate crystallin subunits from human alpha crystallin. Three distinct peaks were separated; by electrophoretic and immunological analyses the first and second peaks were identified as alpha B and alpha A respectively. On the other hand, peak 3 appeared to be a modified form of alpha crystallin. The ratio of alpha A and alpha B proteins was 3:1 in 1 day old lenses which gradually changed to 2:1 in 17 year old lenses and to 1:1 in the 50 and 82 year old whole lenses and 82 year old lens cortex, with a concomitant increase in the modified alpha, suggesting that alpha A subunits are relatively more involved in aggregation. Analysis of the 82 year old lens nucleus also supported this conclusion. The RP-HPLC analysis of the HMW aggregate fraction showed substantial enrichment of the modified alpha. The alpha A and alpha B subunits independently reassociated to form polymeric alpha crystallin whereas the modified alpha reassociated to form HMW aggregates as shown by molecular sieve HPLC. Hence it appears that the HMW aggregate peak was constituted by modified alpha crystallin. Only in the peak 3 material the 280 nm absorbance was about 2-fold higher than what was expected from the actual protein content. The data suggest that the changes induced by post-translational modifications may have some role in the formation of modified alpha. The present RP-HPLC method is useful in separating these modified alpha from the unmodified alpha A and alpha B subunits.

  4. Radiosynthesis and in vitro validation of 3H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand

    DEFF Research Database (Denmark)

    Magnussen, Janus H.; Ettrup, Anders; Donat, Cornelius K.

    2015-01-01

    The neuronal alpha 7 nicotinic acetylcholine receptor is a homo-pentameric ligand-gated ion channel that is a promising drug target for cognitive deficits in Alzheimer's disease and schizophrenia. We have previously described 11C-NS14492 as a suitable agonist radioligand for in vivo positron...... emission tomography (PET) occupancy studies of the alpha 7 nicotinic receptor in the pig brain. In order to investigate the utility of the same compound for in vitro studies, 3H-NS14492 was synthesized and its binding properties were characterized using in vitro autoradiography and homogenate binding...... assays in pig frontal cortex. 3H-NS14492 showed specific binding to alpha 7 nicotinic receptors in autoradiography, revealing a dissociation constant (Kd) of 2.1 ± 0.7 nM and a maximum number of binding sites (Bmax) of 15.7±2.0 fmol/mg tissue equivalent. Binding distribution was similar...

  5. Alpha1-antitrypsin deficiency

    DEFF Research Database (Denmark)

    Stolk, Jan; Seersholm, Niels; Kalsheker, Noor

    2006-01-01

    The Alpha One International Registry (AIR), a multinational research program focused on alpha1-antitrypsin (AAT) deficiency, was formed in response to a World Health Organization recommendation. Each of the nearly 20 participating countries maintains a national registry of patients with AAT defic...

  6. Alpha Thalassemia (For Parents)

    Science.gov (United States)

    ... Safe Videos for Educators Search English Español Alpha Thalassemia KidsHealth / For Parents / Alpha Thalassemia What's in this ... Symptoms Diagnosis Treatment Print en español Alfa talasemia Thalassemias Thalassemias are a group of blood disorders that ...

  7. Buffett’s Alpha

    DEFF Research Database (Denmark)

    Frazzini, Andrea; Kabiller, David; Heje Pedersen, Lasse

    Berkshire Hathaway has realized a Sharpe ratio of 0.76, higher than any other stock or mutual fund with a history of more than 30 years, and Berkshire has a significant alpha to traditional risk factors. However, we find that the alpha becomes insignificant when controlling for exposures to Betting...

  8. Alpha clustering in nuclei

    International Nuclear Information System (INIS)

    Hodgson, P.E.

    1990-01-01

    The effects of nucleon clustering in nuclei are described, with reference to both nuclear structure and nuclear reactions, and the advantages of using the cluster formalism to describe a range of phenomena are discussed. It is shown that bound and scattering alpha-particle states can be described in a unified way using an energy-dependent alpha-nucleus potential. (author)

  9. Enantioselective conjugate radical addition to alpha'-hydroxy enones.

    Science.gov (United States)

    Lee, Sunggi; Lim, Chae Jo; Kim, Sunggak; Subramaniam, Rajesh; Zimmerman, Jake; Sibi, Mukund P

    2006-09-14

    Enantioselective conjugate radical addition to alpha'-hydroxy alpha,beta-unsaturated ketones, compounds containing bidentate donors, has been investigated. It has been found that radical additions to alpha'-hydroxy alpha,beta-unsaturated ketones in the presence of Mg(NTf2)2 and bisoxazoline ligand 5a proceeded cleanly, yielding the addition products in high chemical yields and good enantiomeric excesses.

  10. Cytokine vaccination: neutralising IL-1alpha autoantibodies induced by immunisation with homologous IL-1alpha

    DEFF Research Database (Denmark)

    Svenson, M; Hansen, M B; Thomsen, Allan Randrup

    2000-01-01

    with IL-1alpha coupled to purified protein derivative of tuberculin (PPD). Both unprimed and primed animals developed IgG aAb to IL-1alpha. These aAb persisted at high levels more than 100 days after vaccination and did not cross-react with murine IL-1beta. The induced anti-IL-1alpha aAb inhibited binding...... in mice by vaccination with recombinant murine IL-1alpha conjugated to PPD. Studies of the effects of IL-1alpha aAb in such animals may help clarify the importance of naturally occurring IL-1alpha aAb in humans and permit the evaluation of future therapies with cytokine aAb in patients...

  11. Search for aligned structure of /sup 12/C-. cap alpha. -/sup 12/C type at high excitation energy in /sup 28/Si. [46 MeV, J,. pi. , resonance, three-body problem

    Energy Technology Data Exchange (ETDEWEB)

    Burnereau, N

    1975-01-01

    The /sup 16/O+/sup 12/C..-->../sup 12/C+..cap alpha..+/sup 12/C reaction is studied mainly at 46MeV (at this energy a state of /sup 28/Si is presumably formed with a spin value of 14/sup +/; resonance of 19.7MeV c.m.). The motivation is to detect an ..cap alpha.. particle with a negligible energy in the c.m. system. This is the signature of the preformation of three aligned clusters in which the average location of the ..cap alpha.. particle is in between the two /sup 12/C's at the center of symmetry of the system. Such a detection is performed by detecting two /sup 12/C's in coincidence at specific angles. The data are understood by three-body calculations with a coupling of relative angular momenta governed by an unique J value. Experimentally, an ..cap alpha.. energy of 200keV is measured with good statistics, supporting the idea of aligned clusters as /sup 28/Si intrinsic shape, related to some highly excited states.

  12. Successful Characterization Strategies for the Active High Risk Y-12 National Security Complex 9201-5 (Alpha-5) Facility, Oak Ridge, TN - 12164

    Energy Technology Data Exchange (ETDEWEB)

    Birchfield, Joseph W. III [Link Technologies (United States); Albrecht, Linda [Alliant Corporation (United States)

    2012-07-01

    Building 9201-5 (Alpha 5) was completed in May 1944 and served as a production facility for National Nuclear Security Administration (NNSA) Y-12 Weapons Plant. During the Manhattan Project, it functioned as a uranium enrichment facility. The facility was renovated and altered over the years, converting the calutrons to support other missions. Alpha 5 consists of 4 floors and a basement measuring approximately 600,000 square feet. The facility contains various pieces of equipment remaining from legacy operations. A significant amount (approximately 200,000 kgs) of mercury (Hg) has been spilled in the facility over the operational history of the building. To further complicate matters, beryllium (Be) contamination in 9201-5 is found throughout approximately sixty percent of the facility. Concentrations varying from very low (< 0.2 micrograms (μg)/100 cm{sup 2}) to areas where concentrations are relatively high, approximately 600 μg/100 cm{sup 2}, in regulated beryllium areas. The primary site related contaminants (SRCs) for the waste in this facility are enriched uranium, depleted uranium, beryllium and mercury. This facility represents the highest environmental risk for DOE-ORO EM and NNSA at Y-12 and must be quickly addressed to minimize impacts to future Y-12 missions, as well as human health and the environment. As part of the American Recovery and Reinvestment Act (ARRA), approximately 700,000 cubic feet of legacy material was removed in 2010 and 2011. In addition, characterization of the 9201-5 facility was scheduled in the winter and spring of 2011. This activity was initiated in January 2011 and was completed in July 2011. Heavy schedule pressure was further complicated by the fact that this building has active utility, security and process systems. Given these complex variables, a unique, out of the box characterization strategy was forged in an effort to bound radiological and chemical contaminants, as well as providing the appropriate level of quality to

  13. Genetics Home Reference: alpha thalassemia

    Science.gov (United States)

    ... Facebook Twitter Home Health Conditions Alpha thalassemia Alpha thalassemia Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Alpha thalassemia is a blood disorder that reduces the production ...

  14. Recombinant human acid alpha-glucosidase: high level production in mouse milk, biochemical characteristics, correction of enzyme deficiency in GSDII KO mice

    NARCIS (Netherlands)

    A.G.A. Bijvoet (Agnes); M.A. Kroos (Marian); F.R. Pieper (Frank); M. Van der Vliet (Martin); H.A. de Boer (Herman); A.T. van der Ploeg (Ans); M.Ph. Verbeet (Martin); A.J.J. Reuser (Arnold)

    1998-01-01

    textabstractGlycogen storage disease type II (GSDII) is caused by lysosomal acid alpha-glucosidase deficiency. Patients have a rapidly fatal or slowly progressive impairment of muscle function. Enzyme replacement therapy is under investigation. For large-scale, cost-effective

  15. Acute Exacerbation of Hepatitis in Liver Cirrhosis with Very High Levels of alpha-Fetoprotein But No Occurrence of Hepatocellular Carcinoma

    Science.gov (United States)

    Park, Sang Jong; Park, Kwang Bo; Paik, So Ya; Ryu, Jin Kyung; Choi, Chang Kyu; Hwang, Tae Joon

    2005-01-01

    Aminotransferase levels do not always increase during acute hepatitis or during an acute flare-up of chronic hepatitis. Persistently increased levels of serum alpha-Fetoprotein in an adult with liver disease suggest not only the presence or progression of hepatocellular carcinoma or its recurrence after hepatic resection or after other therapeutic approaches such as chemotherapy or chemoembolization, but also it suggests that there is an acute exacerbation of hepatitis or liver cirrhosis. We report here on two unusual cases of HBV- & HCV-related liver cirrhosis with acute exacerbation of hepatitis in which there was an insignificant elevation of the aminotransferase levels, but there were markedly increased alpha-Fetoprotein levels observed. The levels of alpha-Fetoprotein decreased gradually in both cases since the beginning of antiviral therapy, which implies that the increased levels were due to aggravation of the accompanying hepatitis. These cases also emphasize that using only the measurement of alpha-Fetoprotein is not sufficient for the diagnosis of hepatocellular carcinoma, and that this diagnosis also requires a more specific measurement such as AFP L3 along with the standard imaging studies. PMID:15906959

  16. High-dose interferon-alpha2a exerts potent activity against human immunodeficiency virus type 1 not associated with antitumor activity in subjects with Kaposi's sarcoma

    NARCIS (Netherlands)

    Frissen, P. H.; de Wolf, F.; Reiss, P.; Bakker, P. J.; Veenhof, C. H.; Danner, S. A.; Goudsmit, J.; Lange, J. M.

    1997-01-01

    Anti-human immunodeficiency virus type 1 (HIV-1) activity was assessed in HIV-1-infected homosexual and bisexual men receiving 18-36 MIU/day of recombinant interferon (IFN)-alpha2a for Kaposi's sarcoma (KS). The median baseline HIV-1 RNA level was 4.99 log10 copies/mL. Seventeen subjects (68%)

  17. Development of a high-throughput screening-compatible assay to identify inhibitors of the CK2alpha/CK2beta interaction

    DEFF Research Database (Denmark)

    Hochscherf, Jennifer; Lindenblatt, Dirk; Steinkrueger, Michaela

    2015-01-01

    Increased activity of protein kinase CK2 is associated with various types of cancer, neurodegenerative diseases, and chronic inflammation. In the search for CK2 inhibitors, attention has expanded toward compounds disturbing the interaction between CK2alpha and CK2beta in addition to established a...

  18. Mechanism and computational model for Lyman-{alpha}-radiation generation by high-intensity-laser four-wave mixing in Kr-Ar gas

    Energy Technology Data Exchange (ETDEWEB)

    Louchev, Oleg A.; Saito, Norihito; Wada, Satoshi [Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198 (Japan); Bakule, Pavel [STFC, ISIS Facility, Rutherford Appleton Laboratory, Chilton, Oxfordshire OX11 0QX (United Kingdom); Yokoyama, Koji [Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198 (Japan); Advanced Meson Science Laboratory, RIKEN Nishina Center, RIKEN, Wako, Saitama 351-0198 (Japan); Ishida, Katsuhiko; Iwasaki, Masahiko [Advanced Meson Science Laboratory, RIKEN Nishina Center, RIKEN, Wako, Saitama 351-0198 (Japan)

    2011-09-15

    We present a theoretical model combined with a computational study of a laser four-wave mixing process under optical discharge in which the non-steady-state four-wave amplitude equations are integrated with the kinetic equations of initial optical discharge and electron avalanche ionization in Kr-Ar gas. The model is validated by earlier experimental data showing strong inhibition of the generation of pulsed, tunable Lyman-{alpha} (Ly-{alpha}) radiation when using sum-difference frequency mixing of 212.6 nm and tunable infrared radiation (820-850 nm). The rigorous computational approach to the problem reveals the possibility and mechanism of strong auto-oscillations in sum-difference resonant Ly-{alpha} generation due to the combined effect of (i) 212.6-nm (2+1)-photon ionization producing initial electrons, followed by (ii) the electron avalanche dominated by 843-nm radiation, and (iii) the final breakdown of the phase matching condition. The model shows that the final efficiency of Ly-{alpha} radiation generation can achieve a value of {approx}5x10{sup -4} which is restricted by the total combined absorption of the fundamental and generated radiation.

  19. Nuclear energy - Standard method for testing the long-term alpha irradiation stability of matrices for solidification of high-level radioactive waste. 2. ed.

    International Nuclear Information System (INIS)

    2004-01-01

    This International Standard specifies a method designed to check the long-term stability of a solid to alpha disintegration by detection of all modifications in the properties of an irradiated sample. The material favoured hitherto is a borosilicate glass, but possible alternatives include: ceramics or glass-ceramics, and other glass compositions

  20. PLE CATALYZED HYDROLYZES OF ALPHA-SUBSTITUTED ALPHA-HYDROXY ESTERS - THE INFLUENCE OF THE SUBSTITUENTS

    NARCIS (Netherlands)

    MOORLAG, H; KELLOGG, RM

    1991-01-01

    The enzymatic hydrolyses of a variety of alpha-substituted mandelic and lactic esters using pig liver esterase (PLE) have been investigated. High to moderate enantioselectivity was found for various alpha-substituted mandelic esters, whereas PLE showed low to no enantioselectivity for

  1. Alpha 1 B- but not alpha 1 A-adrenoceptors mediate inositol phosphate generation

    NARCIS (Netherlands)

    Michel, M. C.; Hanft, G.; Gross, G.

    1990-01-01

    We used novel highly subtype-selective antagonists to study whether alpha 1A- and/or alpha 1B-adrenoceptors mediate the stimulation of inositol phosphate generation by noradrenaline in rat cerebral cortex. Phentolamine (10 microM) and prazosin (100 nM) completely abolished the stimulated inositol

  2. High-Affinity Methanotrophy Informed by Genome-Wide Analysis of Upland Soil Cluster Alpha (USCα) from Axel Heiberg Island, Canadian High Arctic

    Science.gov (United States)

    Rusley, C.; Onstott, T. C.; Lau, M.

    2017-12-01

    Methane (CH4) is a potent greenhouse gas whose proper budgeting is vital to climate predictions. Recent studies have identified upland Arctic mineral cryosols as consistent CH4 sinks, drawing CH4 from both the atmosphere and underlying anaerobic soil layers. Global atmospheric CH4 uptake is proposed to be mediated by high-affinity methanotrophs based on the detection of the marker gene pmoA (particulate methane monooxygenase beta subunit). However, a lack of pure cultures and scarcity of genomic information have hindered our understanding of their metabolic capabilities and versatility. Together with the missing genetic linkage between its pmoA and 16S ribosomal RNA (rRNA) gene, the factors that control the distribution and magnitude of high-affinity methanotrophy in the Arctic permafrost-affected region have remained elusive. Using 21 metagenomic datasets of surface soils obtained from long-term core incubation experiments,1 this bioinformatics study aimed to reconstruct the draft genome of the Upland Soil Cluster α-proteobacteria (USCα), the high-affinity methanotroph previously detected in the samples,2 and to determine its phylogeny and metabolic requirements. We obtained a genome bin containing the high-affinity form of the USCα-like pmoA gene. The 3.03 Mbp assembly is 91.6% complete with a unique set of single-copy marker genes. The 16S rRNA gene fragment of USCα belongs to the α-proteobacterial family Beijerinckiaceae. Genome annotation indicates possible formaldehyde oxidation via tetrahydromethanopterin-linked C1 transfer pathways, acetate utilization, carbon fixation via the Calvin-Benson-Bassham cycle, and glycogen production. Notably, the key enzymes for formaldehyde assimilation via the serine and ribulose monophosphate pathways are missing. The presence of genes encoding nitrate reductase and hemoglobin suggests adaptation to low O2 under water-logged conditions. Since USCα has versatile carbon metabolisms, it may not be an obligate methanotroph

  3. National Physics Conference

    International Nuclear Information System (INIS)

    Oancea, Margareta; Sandu, Doina; Calboreanu, Rodica

    2000-01-01

    The National Physics Conference organized annually by the Romanian Physical Society has been held in Constanta, Romania on September 21-23, 2000. It covered the following 12 sections: - 1. Astrophysics and High Energy (9 reports); - 2. Atomic and Molecular Physics (20 reports); - 3. Nuclear Physics (18 reports); - 4. Technical and Engineering Physics (34 reports); - 5. Condensed Matter Physics (67 reports); - 6. Optics and Quantum Electronics (12 reports); - 7. Plasma Physics (27 reports); - 8. Biophysics (30 reports); - 9. Physics for Energy (17 reports); - 10. Mathematical and Computational Physics (20 reports); -11. Physics and Education (8 reports); - 12. Earth and Environmental Physics (16 reports). The proceedings contains mainly short communications

  4. CONFERENCE: Muon spin rotation

    Energy Technology Data Exchange (ETDEWEB)

    Karlsson, Erik

    1986-11-15

    An international physics conference centred on muons without a word about leptons, weak interactions, EMC effects, exotic decay modes or any other standard high energy physics jargon. Could such a thing even have been imagined ten years ago? Yet about 120 physicists and chemists from 16 nations gathered at the end of June in Uppsala (Sweden) for their fourth meeting on Muon Spin Rotation, Relaxation and Resonance, without worrying about the muon as an elementary particle. This reflects how the experimental techniques based on the muon spin interactions have reached maturity and are widely recognized by condensed matter physicists and specialized chemists as useful tools.

  5. Determination of hCG-alpha subunit in threatened pregnancy

    International Nuclear Information System (INIS)

    Talas, M.; Pohanka, J.; Fingerova, H.; Janouskova, M.; Krikal, Z.; Prasilova, J.; Zupkova, H.

    1987-01-01

    Radioimmunoassay of the hCG-alpha subunit was made using an antibody anti hCG-alpha serum, highly purified hCG-alpha for 125 I-labelling and the standard hCG-alpha. Sera of healthy pregnant women sampled throughout the whole pregnancies were used to determine x-bar±S.D. of hCG-alpha for 14-day intervals. Included in the study were groups of women with high risk of premature labor, late toxemia of pregnancy, twins and fetal hypotrophy. It was shown that increased hCG-alpha is found in pregnant women in whom signs of late toxemia of pregnancy are combined with high risk of premature labor, or with twin pregnancies, while in those with fetal hypotrophy hCG-alpha is within normal limits. (author). 3 figs., 7 refs

  6. XIII International science and technology conference High-tech chemical technologies-2010 with elements of Scientific school for young people Innovations in chemistry: achievements and prospects. Summaries of reports

    International Nuclear Information System (INIS)

    2010-01-01

    Materials of the XIII International science and technology conference High-tech chemical technologies-2010 with elements of Scientific school for young people Innovations in chemistry: achievements and prospects (29 June-2 July 2010, Ivanovo) are presented. During the conference the following areas: theoretical aspects of chemical technology; technology of deep oil refining and the production of organic substances; technology of drugs and biologically active substances; technology of inorganic materials, polymers and composites based on them - the technological principles and methods of synthesis, modification, and processing; environmental and economic problems of chemical technologies and their solutions are considered [ru

  7. Role of G308 promoter variant of tumor necrosis factor alpha gene on weight loss and metabolic parameters after a high monounsaturated versus a high polyunsaturated fat hypocaloric diets.

    Science.gov (United States)

    de Luis, Daniel A; Aller, Rocío; Izaola, Olatz; Gonzalez Sagrado, Manuel; Conde, Rosa

    2013-09-07

    The aim of our study was to investigate the influence of G-308 promoter variant of the tumor necrosis factor (TNF) alpha gene on metabolic changes and weight loss secondary to a high monounsaturated fat vs a high polyunsaturated fat hypocaloric diet in obese subjects. A sample of 261 obese subjects were enrolled in a consecutive prospective way, from May 2011 to July 2012 in a tertiary hospital. In the basal visit, patients were randomly allocated during 3 months to Diet M (high monounsaturated fat hypocaloric diet) and Diet P (high polyunsaturated fat hypocaloric diet). One hundred and ninety seven patients (73.2%) had the genotype G-308G and 64 (26.8%) patients had the genotype G-308A. There were no significant differences between the effects (on weight, body mass index (BMI), waist circumference, fat mass) in either genotype group with both diets. With the diet type P and in genotype G-308G, glucose levels (-6.7(22.1)mg/dl vs -3.7(2.2)mg/dl: p = 0.02), HOMA-R (-0.6(2.1)units vs -0.26(3.1)units: p = 0.01), insulin levels (-1.7(6.6)UI/L vs -0.6(7.1)UI/L: p = 0.009), total cholesterol levels (-15.3(31.1)mg/dl vs -8.4(22.1)mg/dl: p = 0.01), LDL cholesterol levels (-10.7(28.1)mg/dl vs -3.8(21.1)mg/dl: p = 0.008) and triglycerides (-12.1(52.1)mg/dl vs -6.6(43.1)mg/dl: p = 0.02) decreased. Carriers of the G-308G promoter variant of TNF alpha gene have a better metabolic response than A-308 obese with a high polyunsaturated fat hypocaloric diet. Copyright © 2012 Elsevier España, S.L. All rights reserved.

  8. 9th international conference on high-temperature reactors - coal and nuclear energy for electricity and gas generation

    International Nuclear Information System (INIS)

    Kelber, G.

    1987-01-01

    The site of the high-temperatur reactor in the Ruhr region neighbouring on a coal-fired power plant is not accidental. The potential of the high-temperature reactor as a central plant element for the supply of heat for heating purposes and process heat covers also the possibility of coal gasification and liquefaction. Therefore the high-temperature reactor is, in the long term, a ray of hope for the coal region, able to compensate for the production-related competitive disadvantages of local coal. It can contribute to guaranteeing in the long term the task of German hard coal as an essential pillar of our energy supply. The VGB as a technical association of thermal power plant operators is particularly committed to the integration of coal and nuclear energy. Within the bounds of its possibilities, it will contribute to promoting the safe and environmentally beneficial generation of electricity from the two primary energy sources. (orig./DG) [de

  9. Conference proceedings

    African Journals Online (AJOL)

    abp

    2015-08-07

    Aug 7, 2015 ... Association, Brazil, 17Universidade Federal de Pelotas, Departamento de Medicina Social Pelotas, RS, Brazil .... line with statements of the Minister of Public Health, Andre Mama ... The high cancer burden in Africa. (breast ...

  10. Hostile environments and high temperature measurements; Proceedings of the Conference, Kansas City, MO, Nov. 6-8, 1989

    Science.gov (United States)

    Topics presented include the identification of stagnant region in a fluidized bed combustor, high sensitivity objective grating speckle, an X-ray beam method for displacement and strain distributions using the moire method, and high-temperature deformation of a Ti-alloy composite under complex loading. Also addressed are a hybrid procedure for dynamic characterization of ceramics at elevated temperature, thermo-structural measurements in a SiC coated carbon-carbon hypersonic glide vehicle, and recent experience with elevated-temperature foil strain gages with application to thin-gage materials.

  11. Spin Conference

    International Nuclear Information System (INIS)

    Anon.

    1983-01-01

    The 5th International Symposium on High Energy Spin Physics met in September at Brookhaven. The symposium has evolved to include a number of diverse specialities: theory, including parity violations and proposed quantum chromodynamics (QCD) tests with polarized beams; experiment, including the large spin effects discovered in high transverse momentum elastic scattering and hyperon production, dibaryons, and magnetic moments; acceleration and storage of polarized protons and electrons; and development of polarized sources and targets

  12. Therapeutic rationale to target highly expressed CDK7 conferring poor outcomes in triple-negative breast cancer

    NARCIS (Netherlands)

    Li, Bo; Chonghaile, Triona Ni; Fan, Yue; Madden, Stephen F.; Klinger, Rut; O'Connor, Aisling E.; Walsh, Louise; O'Hurley, Gillian; Udupi, Girish Mallya; Joseph, Jesuchristopher; Tarrant, Finbarr; Conroy, Emer; Gaber, Alexander; Chin, Suet-Feung; Bardwell, Helen A; Provenzano, Elena; Crown, John; Dubois, Thierry; Linn, Sabine; Jirstrom, Karin; Caldas, Carlos; O'Connor, Darran P; Gallagher, William M

    2017-01-01

    Triple-negative breast cancer (TNBC) patients commonly exhibit poor prognosis and high relapse after treatment, but there remains a lack of biomarkers and effective targeted therapies for this disease. Here, we report evidence highlighting the cell-cycle–related kinase CDK7 as a driver and candidate

  13. Alpha Hydroxy Acids

    Science.gov (United States)

    ... or tenderness (8), chemical burns (6), and increased sunburn (3). The frequency of such reports for skin ... bear a statement that conveys the following information: Sunburn Alert: This product contains an alpha hydroxy acid ( ...

  14. Justify your alpha

    NARCIS (Netherlands)

    Lakens, Daniel; Adolfi, Federico G.; Albers, Casper J.; Anvari, Farid; Apps, Matthew A.J.; Argamon, Shlomo E.; Baguley, Thom; Becker, Raymond B.; Benning, Stephen D.; Bradford, Daniel E.; Buchanan, Erin M.; Caldwell, Aaron R.; Van Calster, Ben; Carlsson, Rickard; Chen, Sau Chin; Chung, Bryan; Colling, Lincoln J.; Collins, Gary S.; Crook, Zander; Cross, Emily S.; Daniels, Sameera; Danielsson, Henrik; Debruine, Lisa; Dunleavy, Daniel J.; Earp, Brian D.; Feist, Michele I.; Ferrell, Jason D.; Field, James G.; Fox, Nicholas W.; Friesen, Amanda; Gomes, Caio; Gonzalez-Marquez, Monica; Grange, James A.; Grieve, Andrew P.; Guggenberger, Robert; Grist, James; Van Harmelen, Anne Laura; Hasselman, Fred; Hochard, Kevin D.; Hoffarth, Mark R.; Holmes, Nicholas P.; Ingre, Michael; Isager, Peder M.; Isotalus, Hanna K.; Johansson, Christer; Juszczyk, Konrad; Kenny, David A.; Khalil, Ahmed A.; Konat, Barbara; Lao, Junpeng; Larsen, Erik Gahner; Lodder, Gerine M.A.; Lukavský, Jiří; Madan, Christopher R.; Manheim, David; Martin, Stephen R.; Martin, Andrea E.; Mayo, Deborah G.; McCarthy, Randy J.; McConway, Kevin; McFarland, Colin; Nio, Amanda Q.X.; Nilsonne, Gustav; De Oliveira, Cilene Lino; De Xivry, Jean Jacques Orban; Parsons, Sam; Pfuhl, Gerit; Quinn, Kimberly A.; Sakon, John J.; Saribay, S. Adil; Schneider, Iris K.; Selvaraju, Manojkumar; Sjoerds, Zsuzsika; Smith, Samuel G.; Smits, Tim; Spies, Jeffrey R.; Sreekumar, Vishnu; Steltenpohl, Crystal N.; Stenhouse, Neil; Świątkowski, Wojciech; Vadillo, Miguel A.; Van Assen, Marcel A.L.M.; Williams, Matt N.; Williams, Samantha E.; Williams, Donald R.; Yarkoni, Tal; Ziano, Ignazio; Zwaan, Rolf A.

    2018-01-01

    In response to recommendations to redefine statistical significance to P ≤ 0.005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.

  15. Antihydrogen detection in ALPHA

    Energy Technology Data Exchange (ETDEWEB)

    Hydomako, Richard, E-mail: rhydomako@phas.ucalgary.ca [University of Calgary, Department of Physics and Astronomy (Canada); Bruun Andresen, Gorm [Aarhus University, Department of Physics and Astronomy (Denmark); Ashkezari, Mohammad Dehghani [Simon Fraser University, Department of Physics (Canada); Baquero-Ruiz, Marcelo [University of California, Department of Physics (United States); Bertsche, William [Swansea University, Department of Physics (United Kingdom); Butler, Eoin [CERN, European Laboratory for Particle Physics (Switzerland); Bowe, Paul David [Aarhus University, Department of Physics and Astronomy (Denmark); Cesar, Claudo Lenz [Universidade Federal do Rio de Janeiro, Instituto de Fsica (Brazil); Chapman, Steve [University of California, Department of Physics (United States); Charlton, Michael [Swansea University, Department of Physics (United Kingdom); Fajans, Joel [University of California, Department of Physics (United States); Friesen, Tim; Fujiwara, Makoto C. [University of Calgary, Department of Physics and Astronomy (Canada); Gill, David Russell [TRIUMF (Canada); Hangst, Jeffrey Scott [Aarhus University, Department of Physics and Astronomy (Denmark); Hardy, Walter Newbold [University of British Columbia, Department of Physics and Astronomy (Canada); Hayano, Ryugo S. [University of Tokyo, Department of Physics (Japan); Hayden, Michael Edward [Simon Fraser University, Department of Physics (Canada); Humphries, Andrew James [Swansea University, Department of Physics (United Kingdom); Jonsell, Svante [Stockholm University, Fysikum (Sweden); Collaboration: ALPHA Collaboration; and others

    2012-12-15

    The ALPHA project is an international collaboration, based at CERN, with the experimental goal of performing precision spectroscopic measurements on antihydrogen. As part of this endeavor, the ALPHA experiment includes a silicon tracking detector. This detector consists of a three-layer array of silicon modules surrounding the antihydrogen trapping region of the ALPHA apparatus. Using this device, the antihydrogen annihilation position can be determined with a spatial resolution of better than 5 mm. Knowledge of the annihilation distribution was a critical component in the recently successful antihydrogen trapping effort. This paper will describe the methods used to reconstruct annihilation events in the ALPHA detector. Particular attention will be given to the description of the background rejection criteria.

  16. Structure based protein engineering of Bacillus stearothermophilus {alpha}-amylase: toward a new substrate specificity

    Energy Technology Data Exchange (ETDEWEB)

    Rasera, Ana Claudia [Sao Paulo Univ., SP (Brazil). Inst. de Ciencias Biomedicas; Iulek, Jorge [Universidade Estadual de Ponta Grossa, PR (Brazil). Inst. de Quimica; Delboni, Luis Fernando; Barbosa, Valma Martins Barbosa [Parana Univ., Curitiba, PR (Brazil). Dept. de Bioquimica

    1997-12-31

    Full text. Structural similarity is observed in all members of {alpha}-amylase family but different products are generated during hydrolysis of starch due to different affinities for intermediate dextrins. In order to understand the structural determinants for this property and to introduce different specificity to {alpha}-amylase of Bacillus stearothermophilus we intend to solve the three dimensional structure by X-ray crystallography of the native protein by using synchrotron radiation at Brazilian National Synchrotron Light Laboratory (LNLS). Protein was over expressed in E. coli, purified and crystallization experiments were carried out by using sparse matrix Crystal Screen and Crystal Screen II from Hampton Research (Laguna Hills, CA, USA). Several condition have produced crystals with some defined characteristic: MDP seems to be important to the crystallization: the preferential pH is around 7.5 with organic buffer (HEPES); organic solvent as 2-propanol seems to be also important for the crystallization. On those condition crystals appeared as cluster of needles or small crystals with high number of nucleation. New conditions are being prepared to improve the site and quality of crystals. Data collection of native of Bacillus stearothermophilus {alpha}-amylase will e done at Protein Crystallography Station at LNLS. Crystal structure of mutated {alpha}-amylase bu site direct mutagenesis of residues suggested by the native crystal structure will be obtained. Co-crystallization of Bacillus stearothermophilus {alpha}-amylase and oligosaccharide will be carried out to identify residues involved in the binding site to plan new mutation. In another series of mutation the putative binding site residues, once identified, will be mutated to residues observed in TAKA amylase to confer different specificity to {alpha}-amylase. Based on the available TAKA amylase structure, in the primary sequence homology and in the three dimensional model of Bacillus stearothermophilus

  17. Alpha - Skew Pi - Armendariz Rings

    Directory of Open Access Journals (Sweden)

    Areej M Abduldaim

    2018-03-01

    Full Text Available In this article we introduce a new concept called Alpha-skew Pi-Armendariz rings (Alpha - S Pi - ARas a generalization of the notion of Alpha-skew Armendariz rings.Another important goal behind studying this class of rings is to employ it in order to design a modern algorithm of an identification scheme according to the evolution of using modern algebra in the applications of the field of cryptography.We investigate general properties of this concept and give examples for illustration. Furthermore, this paperstudy the relationship between this concept and some previous notions related to Alpha-skew Armendariz rings. It clearly presents that every weak Alpha-skew Armendariz ring is Alpha-skew Pi-Armendariz (Alpha-S Pi-AR. Also, thisarticle showsthat the concepts of Alpha-skew Armendariz rings and Alpha-skew Pi- Armendariz rings are equivalent in case R is 2-primal and semiprime ring.Moreover, this paper proves for a semicommutative Alpha-compatible ringR that if R[x;Alpha] is nil-Armendariz, thenR is an Alpha-S Pi-AR. In addition, if R is an Alpha - S Pi -AR, 2-primal and semiprime ring, then N(R[x;Alpha]=N(R[x;Alpha]. Finally, we look forwardthat Alpha-skew Pi-Armendariz rings (Alpha-S Pi-ARbe more effect (due to their properties in the field of cryptography than Pi-Armendariz rings, weak Armendariz rings and others.For these properties and characterizations of the introduced concept Alpha-S Pi-AR, we aspire to design a novel algorithm of an identification scheme.

  18. Co-expression of G2-EPSPS and glyphosate acetyltransferase GAT genes conferring high tolerance to glyphosate in soybean

    OpenAIRE

    Guo, Bingfu; Guo, Yong; Hong, Huilong; Jin, Longguo; Zhang, Lijuan; Chang, Ru-Zhen; Lu, Wei; Lin, Min; Qiu, Li-Juan

    2015-01-01

    Glyphosate is a widely used non-selective herbicide with broad spectrum of weed control around the world. At present, most of the commercial glyphosate tolerant soybeans utilize glyphosate tolerant gene CP4-EPSPS or glyphosate acetyltransferase gene GAT separately. In this study, both glyphosate tolerant gene G2-EPSPS and glyphosate degraded gene GAT were co-transferred into soybean and transgenic plants showed high tolerance to glyphosate. Molecular analysis including PCR, Sothern blot, qRT-...

  19. Dense sampled transmission matrix for high resolution angular spectrum imaging through turbid media via compressed sensing (Conference Presentation)

    Science.gov (United States)

    Jang, Hwanchol; Yoon, Changhyeong; Choi, Wonshik; Eom, Tae Joong; Lee, Heung-No

    2016-03-01

    We provide an approach to improve the quality of image reconstruction in wide-field imaging through turbid media (WITM). In WITM, a calibration stage which measures the transmission matrix (TM), the set of responses of turbid medium to a set of plane waves with different incident angles, is preceded to the image recovery. Then, the TM is used for estimation of object image in image recovery stage. In this work, we aim to estimate highly resolved angular spectrum and use it for high quality image reconstruction. To this end, we propose to perform a dense sampling for TM measurement in calibration stage with finer incident angle spacing. In conventional approaches, incident angle spacing is made to be large enough so that the columns in TM are out of memory effect of turbid media. Otherwise, the columns in TM are correlated and the inversion becomes difficult. We employ compressed sensing (CS) for a successful high resolution angular spectrum recovery with dense sampled TM. CS is a relatively new information acquisition and reconstruction framework and has shown to provide superb performance in ill-conditioned inverse problems. We observe that the image quality metrics such as contrast-to-noise ratio and mean squared error are improved and the perceptual image quality is improved with reduced speckle noise in the reconstructed image. This results shows that the WITM performance can be improved only by executing dense sampling in the calibration stage and with an efficient signal reconstruction framework without elaborating the overall optical imaging systems.

  20. From Mahan excitons to Landau levels at high magnetic fields: 2DFT spectroscopy reveals hidden quantum correlations (Conference Presentation)

    Science.gov (United States)

    Karaiskaj, Denis

    2017-02-01

    Two-dimensional electron gases have been the subject of research for decades. Modulation doped GaAs quantum wells in the absence of magnetic fields exhibit interesting many-body physics such as the Fermi edge singularity or Mahan exciton and can be regarded as a collective excitation of the system. Under high magnetic fields Landau levels form which have been studied using transport and optical measurements. Nonlinear coherent two-dimensional Fourier transform (2DFT) spectroscopy however provides new insights into these systems. We present the 2DFT spectra of Mahan Excitons associated with the heavy-hole and light-hole resonances observed in a modulation doped GaAs/AlGaAs single quantum well [1]. These resonances are observed to be strongly coupled through many-body interactions. The 2DFT spectra were measured using co-linear, cross-linear, and co-circular polarizations and reveal striking differences. Furthermore, 2DFT spectra at high magnetic fields performed at the National High Magnetic Field Lab (NHMFL) in Tallahassee, Florida will be discussed. The spectra exhibit new features and peculiar line shapes suggesting interesting underlying physics. [1] J. Paul, C. E. Stevens, C. Liu, P. Dey, C. McIntyre, V. Turkowski, J. L. Reno, D. J. Hilton, and D. Karaiskaj, Phys. Rev. Lett.116, 157401 (2016).

  1. ALPHA-2: the sequel

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    While many experiments are methodically planning for intense works over the long shutdown, there is one experiment that is already working at full steam: ALPHA-2. Its final components arrived last month and will completely replace the previous ALPHA set-up. Unlike its predecessor, this next generation experiment has been specifically designed to measure the properties of antimatter.   The ALPHA team lower the new superconducting solenoid magnet into place. The ALPHA collaboration is working at full speed to complete the ALPHA-2 set-up for mid-November – this will give them a few weeks of running before the AD shutdown on 17 December. “We really want to get some experience with this device this year so that, if we need to make any changes, we will have time during the long shutdown in which to make them,” says Jeffrey Hangst, ALPHA spokesperson. “Rather than starting the 2014 run in the commissioning stage, we will be up and running from the get go.&...

  2. ITER Plasma at Ion Cyclotron Frequency Domain: The Fusion Alpha Particles Diagnostics Based on the Stimulated Raman Scattering of Fast Magnetosonic Wave off High Harmonic Ion Bernstein Modes

    Science.gov (United States)

    Stefan, V. Alexander

    2014-10-01

    A novel method for alpha particle diagnostics is proposed. The theory of stimulated Raman scattering, SRS, of the fast wave and ion Bernstein mode, IBM, turbulence in multi-ion species plasmas, (Stefan University Press, La Jolla, CA, 2008). is utilized for the diagnostics of fast ions, (4)He (+2), in ITER plasmas. Nonlinear Landau damping of the IBM on fast ions near the plasma edge leads to the space-time changes in the turbulence level, (inverse alpha particle channeling). The space-time monitoring of the IBM turbulence via the SRS techniques may prove efficient for the real time study of the fast ion velocity distribution function, spatial distribution, and transport. Supported by Nikola Tesla Labs., La Jolla, CA 92037.

  3. Versatile quantitative phase imaging system applied to high-speed, low noise and multimodal imaging (Conference Presentation)

    Science.gov (United States)

    Federici, Antoine; Aknoun, Sherazade; Savatier, Julien; Wattellier, Benoit F.

    2017-02-01

    Quadriwave lateral shearing interferometry (QWLSI) is a well-established quantitative phase imaging (QPI) technique based on the analysis of interference patterns of four diffraction orders by an optical grating set in front of an array detector [1]. As a QPI modality, this is a non-invasive imaging technique which allow to measure the optical path difference (OPD) of semi-transparent samples. We present a system enabling QWLSI with high-performance sCMOS cameras [2] and apply it to perform high-speed imaging, low noise as well as multimodal imaging. This modified QWLSI system contains a versatile optomechanical device which images the optical grating near the detector plane. Such a device is coupled with any kind of camera by varying its magnification. In this paper, we study the use of a sCMOS Zyla5.5 camera from Andor along with our modified QWLSI system. We will present high-speed live cell imaging, up to 200Hz frame rate, in order to follow intracellular fast motions while measuring the quantitative phase information. The structural and density information extracted from the OPD signal is complementary to the specific and localized fluorescence signal [2]. In addition, QPI detects cells even when the fluorophore is not expressed. This is very useful to follow a protein expression with time. The 10 µm spatial pixel resolution of our modified QWLSI associated to the high sensitivity of the Zyla5.5 enabling to perform high quality fluorescence imaging, we have carried out multimodal imaging revealing fine structures cells, like actin filaments, merged with the morphological information of the phase. References [1]. P. Bon, G. Maucort, B. Wattellier, and S. Monneret, "Quadriwave lateral shearing interferometry for quantitative phase microscopy of living cells," Opt. Express, vol. 17, pp. 13080-13094, 2009. [2] P. Bon, S. Lécart, E. Fort and S. Lévêque-Fort, "Fast label-free cytoskeletal network imaging in living mammalian cells," Biophysical journal, 106

  4. High-quality electron beam generation and bright betatron radiation from a cascaded laser wakefield accelerator (Conference Presentation)

    Science.gov (United States)

    Liu, Jiansheng; Wang, Wentao; Li, Wentao; Qi, Rong; Zhang, Zhijun; Yu, Changhai; Wang, Cheng; Liu, Jiaqi; Qing, Zhiyong; Ming, Fang; Xu, Yi; Leng, Yuxin; Li, Ruxin; Xu, Zhizhan

    2017-05-01

    One of the major goals of developing laser wakefiled accelerators (LWFAs) is to produce compact high-energy electron beam (e-beam) sources, which are expected to be applied in developing compact x-ray free-electron lasers and monoenergetic gamma-ray sources. Although LWFAs have been demonstrated to generate multi-GeV e-beams, to date they are still failed to produce high quality e beams with several essential properties (narrow energy spread, small transverse emittance and high beam charge) achieved simultaneously. Here we report on the demonstration of a high-quality cascaded LWFA experimentally via manipulating electron injection, seeding in different periods of the wakefield, as well as controlling energy chirp for the compression of energy spread. The cascaded LWFA was powered by a 1-Hz 200-TW femtosecond laser facility at SIOM. High-brightness e beams with peak energies in the range of 200-600 MeV, 0.4-1.2% rms energy spread, 10-80 pC charge, and 0.2 mrad rms divergence are experimentally obtained. Unprecedentedly high 6-dimensional (6-D) brightness B6D,n in units of A/m2/0.1% was estimated at the level of 1015-16, which is very close to the typical brightness of e beams from state-of-the-art linac drivers and several-fold higher than those of previously reported LWFAs. Furthermore, we propose a scheme to minimize the energy spread of an e beam in a cascaded LWFA to the one-thousandth-level by inserting a stage to compress its longitudinal spatial distribution via velocity bunching. In this scheme, three-segment plasma stages are designed for electron injection, e-beam length compression, and e-beam acceleration, respectively. A one-dimensional theory and two-dimensional particle-in-cell simulations have demonstrated this scheme and an e beam with 0.2% rms energy spread and low transverse emittance could be generated without loss of charge. Based on the high-quality e beams generated in the LWFA, we have experimentally realized a new scheme to enhance the

  5. IAEA General Conference begins annual session

    International Nuclear Information System (INIS)

    2001-01-01

    The document gives general information about the opening and the programme of the 45th regular session of the IAEA General Conference (17-21 September 2001, Austria Center Vienna). The conference is attended by ministers and high-level governmental representatives from 132 Member States of the IAEA

  6. IAEA General Conference begins annual session

    International Nuclear Information System (INIS)

    2000-01-01

    The document gives general information about the opening and the programme of the 44th regular session of the IAEA General Conference (18 -22 September 2000, Austria Center Vienna). The conference is attended by ministers and high-level governmental representatives from 130 Member States of the IAEA

  7. Applying alpha-channeling to mirror machines

    Energy Technology Data Exchange (ETDEWEB)

    Zhmoginov, A. I.; Fisch, N. J. [Department of Astrophysical Sciences, Princeton University, Princeton, New Jersey 08544 (United States)

    2012-05-15

    The {alpha}-channeling effect entails the use of radio-frequency waves to expel and cool high-energetic {alpha} particles born in a fusion reactor; the device reactivity can then be increased even further by redirecting the extracted energy to fuel ions. Originally proposed for tokamaks, this technique has also been shown to benefit open-ended fusion devices. Here, the fundamental theory and practical aspects of {alpha} channeling in mirror machines are reviewed, including the influence of magnetic field inhomogeneity and the effect of a finite wave region on the {alpha}-channeling mechanism. For practical implementation of the {alpha}-channeling effect in mirror geometry, suitable contained weakly damped modes are identified. In addition, the parameter space of candidate waves for implementing the {alpha}-channeling effect can be significantly extended through the introduction of a suitable minority ion species that has the catalytic effect of moderating the transfer of power from the {alpha}-channeling wave to the fuel ions.

  8. INFCE plenary conference documents

    International Nuclear Information System (INIS)

    This document consists of the reports to the First INFCE Plenary Conference (November 1978) by the Working Groups a Plenary Conference of its actions and decisions, the Communique of the Final INFCE Plenary Conference (February 1980), and a list of all documents in the IAEA depository for INFCE

  9. Conferences are like swans

    OpenAIRE

    Corker, Chris

    2012-01-01

    Chris Corker was the lead on bringing the 2011 Higher Education Research Scholarship Group Conference to fruition, both in the months preceding the event and on the day. In this viewpoint, Chris shares his experiences of conference administration and delivery, and explores how conferences and swans have more in common that you would imagine.

  10. COAL Conference Poster

    OpenAIRE

    Brown, Taylor Alexander; McGibbney, Lewis John

    2017-01-01

    COAL Conference Poster This archive contains the COAL conference poster for the AGU Fall Meeting 2017 by Taylor Alexander Brown. The Inkscape SVG source is available at https://github.com/capstone-coal/coal-conference-poster/ under the Creative Commons Attribution-ShareAlike 4.0 International license.

  11. Alpha decay and various problems related to it

    International Nuclear Information System (INIS)

    Katori, Kenji

    1992-01-01

    On the proton-excessive nucleus side of lanthanide and actinide, alpha decay is the main decay mode. In lanthanide region, alpha decay has been measured to the drip line for most even-even nuclei. In the measurement of alpha decay, emitted energy and life are measured, but the measurement of converted alpha width remains in the limited range. In order to obtain the converted alpha width of high accuracy, the nucleus formation in larger quantity on the drip line and the simultaneous measurement with a multiple detector system including gamma ray and beta ray are required. In this paper, three topics related to alpha cluster and alpha decay and the problems that confront at present are discussed. The continuation to exist of alpha cluster structure to heavy nuclei, the analysis of lanthanide nucleus region by the alpha giant resonance model, and the new data on the alpha ray decaying from the mass of 175, 176 and 177 are reported. In lanthanide nucleus region, remarkable interference was not observed between beta-2 and beta-3 modes in the converted alpha width measured between the ground states. The present problems in alpha decay are enumerated. (K.I.)

  12. Structure and dynamics of alpha-tocopherol in model membranes and in solution: a broad-line and high-resolution NMR study

    International Nuclear Information System (INIS)

    Ekiel, I.H.; Hughes, L.; Burton, G.W.; Jovall, P.A.; Ingold, K.U.; Smith, I.C.

    1988-01-01

    Nuclear magnetic resonance has been applied to study the conformational dynamics of alpha-tocopherol (vitamin E) in solution and in model membranes. In nonviscous solution, 1 H nuclear magnetic resonance (NMR) showed that alpha-tocopherol is in rapid equilibrium between two or more puckered conformers of its heterocyclic ring. The most likely conformers to be so involved are the two half-chair forms. Deuterium NMR spectra of specifically deuteriated alpha-tocopherol in multilamellar dispersions of egg phosphatidylcholine, measured in the liquid-crystalline state, were characteristic of axially symmetric motional averaging. The orientation of the rotational axis within the molecular framework was determined. Studies on oriented multilamellar membranes revealed that this axis is perpendicular to the surface of the membrane. The profile of quadrupolar splittings along the hydrophobic tail does not have a plateau, in contrast to that of the fatty acyl chains of the membrane lipids. Longitudinal relaxation times (T1) were short. The presence of a minimum in their temperature dependence shows that molecular motion with an effective correlation time tau eff approximately equal to 3 X 10(-9)s is responsible for relaxation. However, the temperatures and absolute values of the minima depend on the position of the deuterium in the molecule, demonstrating that tau eff represents a complex blend of motions

  13. Production of alpha emitters for therapy

    International Nuclear Information System (INIS)

    Vucina, J.; Orlic, M.; Lukic, D.

    2006-01-01

    The basis for the introduction of alpha emitters into nuclear medical practice are their radiobiological properties. High LET values and short ranges in biological tissues are advantageous in comparison with nowadays most often used beta emitters, primarily 90 Y and 131 I. Given are the most important criteria for the introduction of a given radionuclide in the routine use. Shown are the procedures for the production of the most important alpha emitters 211 At, 212 Bi and 213 Bi. (author)

  14. Vancouver Cyclotron Conference

    International Nuclear Information System (INIS)

    Clark, David J.

    1993-01-01

    Although no longer on the high energy frontier, the cyclotron field is still a major scientific growth area. Its progress is highlighted at the international conference on cyclotron design, development and utilization held at intervals of about three years, under the auspices of the International Union of Pure and Applied Physics (IUPAP). Vancouver, surrounded by mountains, water and some cyclotrons, provided a pleasant setting for the 13th Conference, held last summer. With over 200 cyclotrons in operation around the world, the attendance, 241 delegates and 26 industrial exhibitors, was a near record, reflecting the flourishing state of the field. The early sessions covered the initial operation of new or upgraded cyclotron facilities. Major facilities completed since the previous Conference in Berlin in May 1989 included the 400 MeV ring cyclotron at Osaka, the U400M cyclotron at Dubna which will be coupled to the U400 to give 20 MeV nucléon uranium beams, the 130 MeV cyclotron at Jyvaskyla (in Finland, the furthest north!), the 110 MeV JAERI machine in Japan, and the 65 MeV proton therapy cyclotron in Nice. Among the facility upgrades were the KFA cyclotron at Julich which will inject the 2.5 GeV storage ring COSY, and the addition of an FM mode to the K=200 CW mode at Uppsala to give protons up to 180 MeV. The impressive current of 1.5 mA at 72 MeV obtained from the PSI Injector II will soon be injected into the 590 MeV ring

  15. MC 93 - Proceedings of the International Conference on Monte Carlo Simulation in High Energy and Nuclear Physics

    Science.gov (United States)

    Dragovitsch, Peter; Linn, Stephan L.; Burbank, Mimi

    1994-01-01

    The Table of Contents for the book is as follows: * Preface * Heavy Fragment Production for Hadronic Cascade Codes * Monte Carlo Simulations of Space Radiation Environments * Merging Parton Showers with Higher Order QCD Monte Carlos * An Order-αs Two-Photon Background Study for the Intermediate Mass Higgs Boson * GEANT Simulation of Hall C Detector at CEBAF * Monte Carlo Simulations in Radioecology: Chernobyl Experience * UNIMOD2: Monte Carlo Code for Simulation of High Energy Physics Experiments; Some Special Features * Geometrical Efficiency Analysis for the Gamma-Neutron and Gamma-Proton Reactions * GISMO: An Object-Oriented Approach to Particle Transport and Detector Modeling * Role of MPP Granularity in Optimizing Monte Carlo Programming * Status and Future Trends of the GEANT System * The Binary Sectioning Geometry for Monte Carlo Detector Simulation * A Combined HETC-FLUKA Intranuclear Cascade Event Generator * The HARP Nucleon Polarimeter * Simulation and Data Analysis Software for CLAS * TRAP -- An Optical Ray Tracing Program * Solutions of Inverse and Optimization Problems in High Energy and Nuclear Physics Using Inverse Monte Carlo * FLUKA: Hadronic Benchmarks and Applications * Electron-Photon Transport: Always so Good as We Think? Experience with FLUKA * Simulation of Nuclear Effects in High Energy Hadron-Nucleus Collisions * Monte Carlo Simulations of Medium Energy Detectors at COSY Jülich * Complex-Valued Monte Carlo Method and Path Integrals in the Quantum Theory of Localization in Disordered Systems of Scatterers * Radiation Levels at the SSCL Experimental Halls as Obtained Using the CLOR89 Code System * Overview of Matrix Element Methods in Event Generation * Fast Electromagnetic Showers * GEANT Simulation of the RMC Detector at TRIUMF and Neutrino Beams for KAON * Event Display for the CLAS Detector * Monte Carlo Simulation of High Energy Electrons in Toroidal Geometry * GEANT 3.14 vs. EGS4: A Comparison Using the DØ Uranium/Liquid Argon

  16. Prepared for the thirtieth annual conference on bioassay analytical and environmental chemistry. Reliable analysis of high resolution gamma spectra

    International Nuclear Information System (INIS)

    Spitz, H.B.; Buschbom, R.; Rieksts, G.A.; Palmer, H.E.

    1985-01-01

    A new method has been developed to reliably analyze pulse height-energy spectra obtained from measurements employing high resolution germanium detectors. The method employs a simple data transformation and smoothing function to calculate background and identify photopeaks and isotopic analysis. This technique is elegant in its simplicity because it avoids dependence upon complex spectrum deconvolution, stripping, or other least-square-fitting techniques which complicate the assessment of measurement reliability. A moving median was chosen for data smoothing because, unlike moving averages, medians are not dominated by extreme data points. Finally, peaks are identified whenever the difference between the background spectrum and the transformed spectrum exceeds a pre-determined number of standard deviations

  17. Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity at high sensitivity levels (Conference Presentation)

    Science.gov (United States)

    Zhao, Jianhua; Zeng, Haishan; Kalia, Sunil; Lui, Harvey

    2017-02-01

    Background: Raman spectroscopy is a non-invasive optical technique which can measure molecular vibrational modes within tissue. A large-scale clinical study (n = 518) has demonstrated that real-time Raman spectroscopy could distinguish malignant from benign skin lesions with good diagnostic accuracy; this was validated by a follow-up independent study (n = 127). Objective: Most of the previous diagnostic algorithms have typically been based on analyzing the full band of the Raman spectra, either in the fingerprint or high wavenumber regions. Our objective in this presentation is to explore wavenumber selection based analysis in Raman spectroscopy for skin cancer diagnosis. Methods: A wavenumber selection algorithm was implemented using variably-sized wavenumber windows, which were determined by the correlation coefficient between wavenumbers. Wavenumber windows were chosen based on accumulated frequency from leave-one-out cross-validated stepwise regression or least and shrinkage selection operator (LASSO). The diagnostic algorithms were then generated from the selected wavenumber windows using multivariate statistical analyses, including principal component and general discriminant analysis (PC-GDA) and partial least squares (PLS). A total cohort of 645 confirmed lesions from 573 patients encompassing skin cancers, precancers and benign skin lesions were included. Lesion measurements were divided into training cohort (n = 518) and testing cohort (n = 127) according to the measurement time. Result: The area under the receiver operating characteristic curve (ROC) improved from 0.861-0.891 to 0.891-0.911 and the diagnostic specificity for sensitivity levels of 0.99-0.90 increased respectively from 0.17-0.65 to 0.20-0.75 by selecting specific wavenumber windows for analysis. Conclusion: Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity at high sensitivity levels.

  18. Overexpression of a modiifed AM79 aroA gene in transgenic maize confers high tolerance to glyphosate

    Institute of Scientific and Technical Information of China (English)

    REN Zhen-jing; CAO Gao-yi; ZHANG Yu-wen; LIU Yan; LIU Yun-jun

    2015-01-01

    It has previously been shown that a bacterial 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene AM79 aroA can be a candidate gene to develop glyphosate-tolerant transgenic crops (Cao et al. 2012). In this study, AM79 aroA was redesigned using the plant biased codons and eliminating the motifs which would lead to the instability of mRNA, to create a synthetic gene that would be expressed highly in plant cel s. The redesigned and artiifcial y synthesized gene, named as mAM79, was cloned into plant expression vector pM3301UbiSpAM79, where mAM79 is fused with signal peptide sequence of pea rib-1,5-bisphospate carboxylase (rbcS) smal subunit and control ed by ubiquitin promoter. The plasmid was transformed into maize (Zea mays) immature embryos using Agrobacterium-mediated transformation method. Total 74 regenerated plants were obtained and PCR analysis showed that these transgenic plants had the integration of mAM79. Southern blot analysis was performed on the genomic DNA from four transgenic lines, and the result showed that one or two copies of mAM79 were integrated into maize genome. RT-PCR analysis result indicated that mAM79 was highly transcribed in transgenic maize plants. When sprayed with glyphosate, transgenic maize line AM85 and AM72 could tolerate 4-fold of commercial usage of glyphosate;however, al the non-transgenic maize plants were kil ed by glyphosate. The results in this study conifrmed that mAM79 could be used to develop glyphosate-tolerant maize, and the obtained transgenic maize lines could be used for the breeding of glyphosate-tolerant maize.

  19. High-throughput label-free detection of aggregate platelets with optofluidic time-stretch microscopy (Conference Presentation)

    Science.gov (United States)

    Jiang, Yiyue; Lei, Cheng; Yasumoto, Atsushi; Ito, Takuro; Guo, Baoshan; Kobayashi, Hirofumi; Ozeki, Yasuyuki; Yatomi, Yutaka; Goda, Keisuke

    2017-02-01

    According to WHO, approximately 10 million new cases of thrombotic disorders are diagnosed worldwide every year. In the U.S. and Europe, their related diseases kill more people than those from AIDS, prostate cancer, breast cancer and motor vehicle accidents combined. Although thrombotic disorders, especially arterial ones, mainly result from enhanced platelet aggregability in the vascular system, visual detection of platelet aggregates in vivo is not employed in clinical settings. Here we present a high-throughput label-free platelet aggregate detection method, aiming at the diagnosis and monitoring of thrombotic disorders in clinical settings. With optofluidic time-stretch microscopy with a spatial resolution of 780 nm and an ultrahigh linear scanning rate of 75 MHz, it is capable of detecting aggregated platelets in lysed blood which flows through a hydrodynamic-focusing microfluidic device at a high throughput of 10,000 particles/s. With digital image processing and statistical analysis, we are able to distinguish them from single platelets and other blood cells via morphological features. The detection results are compared with results of fluorescence-based detection (which is slow and inaccurate, but established). Our results indicate that the method holds promise for real-time, low-cost, label-free, and minimally invasive detection of platelet aggregates, which is potentially applicable to detection of platelet aggregates in vivo and to the diagnosis and monitoring of thrombotic disorders in clinical settings. This technique, if introduced clinically, may provide important clinical information in addition to that obtained by conventional techniques for thrombotic disorder diagnosis, including ex vivo platelet aggregation tests.

  20. Conference Attendees’ Satisfaction: Evidence from Belgrade (Serbia

    Directory of Open Access Journals (Sweden)

    Dunjić Jelena

    2012-10-01

    Full Text Available Conference industry brings significant economic effects and that is one of the reasons why many destinations around the world strive to organize conferences, especially the international ones, which make bigger economic effects. According to the Strategy of tourism development of the Republic of Serbia (2005-2015, city break and business tourism are tourism products of high priority, which can provide short-term positioning of Novi Sad and Belgrade, at the first place, at the international tourism market, and contribute to the growth of tourism turnover of foreign travellers.Belgrade is the capital and the largest city in Serbia. It is very well equipped with necessary infrastructure for organizing business events such as conferences, congresses, meetings etc. Lately, the number of international business events in Serbia is increasing and the majority of those events are organized in Belgrade. However, there are very few surveys which are examining satisfaction of the conference attendees in Serbia. This topic is often ignored despite the fact that the attendees satisfaction is substantial for organizers and all other relevant stakeholders at host destination. Therefore, the aim of this paper is to analyze the satisfaction of the conference attendees, as they are final consumers of conference tourist product and their experience regarding both conference and host destination is thus essential to destination marketing and management organizations, conference centres, hotel managers, meeting planners and all other stakeholders involved in conference industry and tourism

  1. 5alphaDH-DOC (5alpha-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate cancer.

    Science.gov (United States)

    Uemura, Motohide; Honma, Seijiro; Chung, Suyoun; Takata, Ryo; Furihata, Mutsuo; Nishimura, Kazuo; Nonomura, Norio; Nasu, Yasutomo; Miki, Tsuneharu; Shuin, Taro; Fujioka, Tomoaki; Okuyama, Akihiko; Nakamura, Yusuke; Nakagawa, Hidewaki

    2010-08-01

    Prostate cancer often relapses during androgen-depletion therapy, even under the castration condition in which circulating androgens are drastically reduced. High expressions of androgen receptor (AR) and genes involved in androgen metabolism indicate a continued role for AR in castration-resistant prostate cancers (CRPCs). There is increasing evidence that some amounts of 5alpha-dihydrotestosterone (DHT) and other androgens are present sufficiently to activate AR within CRPC tissues, and enzymes involved in the androgen and steroid metabolism, such as 5alpha-steroid reductases, are activated in CRPCs. In this report, we screened eight natural 5alphaDH-steroids to search for novel products of 5alpha-steroid reductases, and identified 11-deoxycorticosterone (DOC) as a novel substrate for 5alpha-steroid reductases in CRPCs. 11-Deoxycorticosterone (DOC) and 5alpha-dihydro-deoxycorticosterone (5alphaDH-DOC) could promote prostate cancer cell proliferation through AR activation, and type 1 5alpha-steroid reductase (SRD5A1) could convert from DOC to 5alphaDH-DOC. Sensitive liquid chromatography-tandem mass spectrometric analysis detected 5alphaDH-DOC in some clinical CRPC tissues. These findings implicated that under an extremely low level of DHT, 5alphaDH-DOC and other products of 5alpha-steroid reductases within CRPC tissues might activate the AR pathway for prostate cancer cell proliferation and survival under castration.

  2. Miniaturizing 3D assay for high-throughput drug and genetic screens for small patient-derived tumor samples (Conference Presentation)

    Science.gov (United States)

    Rotem, Asaf; Garraway, Levi; Su, Mei-Ju; Basu, Anindita; Regev, Aviv; Struhl, Kevin

    2017-02-01

    Three-dimensional growth conditions reflect the natural environment of cancer cells and are crucial to be performed at drug screens. We developed a 3D assay for cellular transformation that involves growth in low attachment (GILA) conditions and is strongly correlated with the 50-year old benchmark assay-soft agar. Using GILA, we performed high-throughput screens for drugs and genes that selectively inhibit or increase transformation, but not proliferation. This phenotypic approach is complementary to our genetic approach that utilizes single-cell RNA-sequencing of a patient sample to identify putative oncogenes that confer sensitivity to drugs designed to specifically inhibit the identified oncoprotein. Currently, we are dealing with a big challenge in our field- the limited number of cells that might be extracted from a biopsy. Small patient-derived samples are hard to test in the traditional multiwell plate and it will be helpful to minimize the culture area and the experimental system. We managed to design a suitable microfluidic device for limited number of cells and perform the assay using image analysis. We aim to test drugs on tumor cells, outside of the patient body- and recommend on the ideal treatment that is tailored to the individual. This device will help to minimize biopsy-sampling volumes and minimize interventions in the patient's tumor.

  3. International Conference on Physics

    CERN Document Server

    2016-01-01

    OMICS International, (conference series) the World Class Open Access Publisher and Scientific Event Organizer is hosting “International Conference on physics” which is going to be the biggest conference dedicated to Physics. The theme “Highlighting innovations and challenges in the field of Physics” and it features a three day conference addressing the major breakthroughs, challenges and the solutions adopted. The conference will be held during June 27-29, 2016 at New Orleans, USA. Will be published in: http://physics.conferenceseries.com/

  4. Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs

    Science.gov (United States)

    Persson, Josefine; Zhang, Yuan; Olafsdottir, Thorunn A.; Thörn, Karolina; Cairns, Tina M.; Wegmann, Frank; Sattentau, Quentin J.; Eisenberg, Roselyn J.; Cohen, Gary H.; Harandi, Ali M.

    2016-01-01

    Genital herpes is one of the most prevalent sexually transmitted infections in both the developing and developed world. Following infection, individuals experience life-long latency associated with sporadic ulcerative outbreaks. Despite many efforts, no vaccine has yet been licensed for human use. Herein, we demonstrated that nasal immunization with an adjuvanted HSV-2 gD envelope protein mounts significant protection to primary infection as well as the establishment of latency and recurrent genital herpes in guinea pigs. Nasal immunization was shown to elicit specific T cell proliferative and IFN-γ responses as well as systemic and vaginal gD-specific IgG antibody (Ab) responses. Furthermore, systemic IgG Abs displayed potent HSV-2 neutralizing properties and high avidity. By employing a competitive surface plasmon resonance (SPR) analysis combined with a battery of known gD-specific neutralizing monoclonal Abs (MAbs), we showed that nasal immunization generated IgG Abs directed to two major discontinuous neutralizing epitopes of gD. These results highlight the potential of nasal immunization with an adjuvanted HSV-2 envelope protein for induction of protective immunity to primary and recurrent genital herpes. PMID:28082979

  5. Assessment of geometry in 2D immune systems using high accuracy laser-based bioprinting techniques (Conference Presentation)

    Science.gov (United States)

    Lauzurica, Sara; Márquez, Andrés.; Molpeceres, Carlos; Notario, Laura; Gómez-Fontela, Miguel; Lauzurica, Pilar

    2017-02-01

    The immune system is a very complex system that comprises a network of genetic and signaling pathways subtending a network of interacting cells. The location of the cells in a network, along with the gene products they interact with, rules the behavior of the immune system. Therefore, there is a great interest in understanding properly the role of a cell in such networks to increase our knowledge of the immune system response. In order to acquire a better understanding of these processes, cell printing with high spatial resolution emerges as one of the promising approaches to organize cells in two and three-dimensional patterns to enable the study the geometry influence in these interactions. In particular, laser assisted bio-printing techniques using sub-nanosecond laser sources have better characteristics for application in this field, mainly due to its higher spatial resolution, cell viability percentage and process automation. This work presents laser assisted bio-printing of antigen-presenting cells (APCs) in two-dimensional geometries, placing cellular components on a matrix previously generated on demand, permitting to test the molecular interactions between APCs and lymphocytes; as well as the generation of two-dimensional structures designed ad hoc in order to study the mechanisms of mobilization of immune system cells. The use of laser assisted bio-printing, along with APCs and lymphocytes emulate the structure of different niches of the immune system so that we can analyse functional requirement of these interaction.

  6. The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels.

    Science.gov (United States)

    Hou, Shangwei; Xu, Rong; Heinemann, Stefan H; Hoshi, Toshinori

    2008-03-11

    Carbon monoxide (CO) is a lethal gas, but it is also increasingly recognized as a physiological signaling molecule capable of regulating a variety of proteins. Among them, large-conductance Ca(2+)- and voltage-gated K(+) (Slo1 BK) channels, important in vasodilation and neuronal firing, have been suggested to be directly stimulated by CO. However, the molecular mechanism of the stimulatory action of CO on the Slo1 BK channel has not been clearly elucidated. We report here that CO reliably and repeatedly activates Slo1 BK channels in excised membrane patches in the absence of Ca(2+) in a voltage-sensor-independent manner. The stimulatory action of CO on the Slo1 BK channel requires an aspartic acid and two histidine residues located in the cytoplasmic RCK1 domain, and the effect persists under the conditions known to inhibit the conventional interaction between CO and heme in other proteins. We propose that CO acts as a partial agonist for the high-affinity divalent cation sensor in the RCK1 domain of the Slo1 BK channel.

  7. Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs.

    Science.gov (United States)

    Persson, Josefine; Zhang, Yuan; Olafsdottir, Thorunn A; Thörn, Karolina; Cairns, Tina M; Wegmann, Frank; Sattentau, Quentin J; Eisenberg, Roselyn J; Cohen, Gary H; Harandi, Ali M

    2016-01-01

    Genital herpes is one of the most prevalent sexually transmitted infections in both the developing and developed world. Following infection, individuals experience life-long latency associated with sporadic ulcerative outbreaks. Despite many efforts, no vaccine has yet been licensed for human use. Herein, we demonstrated that nasal immunization with an adjuvanted HSV-2 gD envelope protein mounts significant protection to primary infection as well as the establishment of latency and recurrent genital herpes in guinea pigs. Nasal immunization was shown to elicit specific T cell proliferative and IFN-γ responses as well as systemic and vaginal gD-specific IgG antibody (Ab) responses. Furthermore, systemic IgG Abs displayed potent HSV-2 neutralizing properties and high avidity. By employing a competitive surface plasmon resonance (SPR) analysis combined with a battery of known gD-specific neutralizing monoclonal Abs (MAbs), we showed that nasal immunization generated IgG Abs directed to two major discontinuous neutralizing epitopes of gD. These results highlight the potential of nasal immunization with an adjuvanted HSV-2 envelope protein for induction of protective immunity to primary and recurrent genital herpes.

  8. Facilitating Learning at Conferences

    DEFF Research Database (Denmark)

    Ravn, Ib; Elsborg, Steen

    2011-01-01

    The typical conference consists of a series of PowerPoint presentations that tend to render participants passive. Students of learning have long abandoned the transfer model that underlies such one-way communication. We propose an al-ternative theory of conferences that sees them as a forum...... for learning, mutual inspiration and human flourishing. We offer five design principles that specify how conferences may engage participants more and hence increase their learning. In the research-and-development effort reported here, our team collaborated with conference organizers in Denmark to introduce...... and facilitate a variety of simple learning techniques at thirty one- and two-day conferences of up to 300 participants each. We present ten of these techniques and data evaluating them. We conclude that if conference organizers allocate a fraction of the total conference time to facilitated processes...

  9. The Cryo-Thermochromatographic Separator (CTS) A new rapid separation and alpha-detection system for on-line chemical studies of highly volatile osmium and hassium (Z=108) tetroxides

    CERN Document Server

    Kirbach, U W; Gregorich, K E; Lee, D M; Ninov, V; Omtvedt, J P; Patin, J B; Seward, N K; Strellis, D A; Sudowe, R; Türler, A; Wilk, P A; Zielinski, P M; Hoffman, D C; Nitsche, H

    2002-01-01

    The Cryo-Thermochromatographic Separator (CTS) was designed and constructed for rapid, continuous on-line separation and simultaneous detection of highly volatile compounds of short-lived alpha-decaying isotopes of osmium and hassium (Hs, Z=108). A flowing carrier gas containing the volatile species is passed through a channel formed by two facing rows of 32 alpha-particle detectors, cooled to form a temperature gradient extending from 247 K at the channel entrance down to 176 K at the exit. The volatile species adsorb onto the SiO sub 2 -coated detector surfaces at a characteristic deposition temperature and are identified by their observed alpha-decay energies. The CTS was tested on-line with OsO sub 4 prepared from sup 1 sup 6 sup 9 sup - sup 1 sup 7 sup 3 Os isotopes produced in sup 1 sup 1 sup 8 sup , sup 1 sup 2 sup 0 Sn( sup 5 sup 6 Fe, 3,4,5n) reactions. An adsorption enthalpy for OsO sub 4 of -40.2+-1.5 kJ/mol on SiO sub 2 was deduced by comparing the measured deposition distribution with Monte Carlo...

  10. Allomyrina dichotoma (Arthropoda: Insecta Larvae Confer Resistance to Obesity in Mice Fed a High-Fat Diet

    Directory of Open Access Journals (Sweden)

    Young-Il Yoon

    2015-03-01

    Full Text Available To clarify the anti-obesity effect of Allomyrina dichotoma larvae (ADL, we previously reported that ADL block adipocyte differentiation on 3T3-L1 cell lines through downregulation of transcription factors, such as peroxisome proliferator-activated receptor-γ (PPARG and CCAAT/enhancer binding protein-α (CEBPA. In this study, we tested whether ADL prevent obesity in mice fed a high-fat diet (HFD and further investigated the mechanism underlying the effects of ADL. All mice were maintained on a normal-fat diet (NFD for 1 week and then assigned to one of five treatment groups: (1 NFD; (2 HFD; (3 HFD and 100 mg·kg−1·day−1 ADL; (4 HFD and 3000 mg·kg−1·day−1ADL; or (5 HFD and 3000 mg·kg−1·day−1 yerba mate (Ilex paraguariensis, positive control. ADL and yerba mate were administered orally daily. Mice were fed experimental diets and body weight was monitored weekly for 6 weeks. Our results indicated that ADL reduced body weight gain, organ weight and adipose tissue volume in a dose-dependent manner. Body weight gain was approximately 22.4% lower compared to mice fed only HFD, but the difference did not reach the level of statistical significance. Real-time polymerase chain reaction (PCR analysis revealed that gene expression levels of PPARG, CEBPA and lipoprotein lipase (LPL in the epididymal fat tissue of HFD-fed mice receiving 3000 mg·kg−1·day−1 ADL were reduced by 12.4-, 25.7-, and 12.3-fold, respectively, compared to mice fed HFD only. Moreover, mice administered ADL had lower serum levels of triglycerides and leptin than HFD-fed mice that did not receive ADL. Taken together our results suggest that ADL and its constituent bioactive compounds hold potential for the treatment and prevention of obesity.

  11. Alpha-tubulin missense mutations correlate with antimicrotubule drug resistance in Eleusine indica.

    Science.gov (United States)

    Yamamoto, E; Zeng, L; Baird, W V

    1998-02-01

    Dinitroaniline herbicides are antimicrotubule drugs that bind to tubulins and inhibit polymerization. As a result of repeated application of dinitroaniline herbicides, highly resistant and intermediately resistant biotypes of goosegrass (Eleusine indica) developed in previously wild-type populations. Three alpha-tubulin cDNA classes (designated TUA1, TUA2, and TUA3) were isolated from each biotype. Nucleotide differences between the susceptible and the resistant (R) alpha-tubulins were identified in TUA1 and TUA2. The most significant differences were missense mutations that occurred in TUA1 of the R and intermediately resistant (I) biotypes. Such mutations convert Thr-239 to Ile in the R biotype and Met-268 to Thr in the I biotype. These amino acid substitutions alter hydrophobicity; therefore, they may alter the dinitroaniline binding property of the protein. These mutations were correlated with the dinitroaniline response phenotypes (Drp). Plants homozygous for susceptibility possessed the wild-type TUA1 allele; plants homozygous for resistance possessed the mutant tua1 allele; and plants heterozygous for susceptibility possessed both wild-type and mutant alleles. Thus, we conclude that TUA1 is at the Drp locus. Using polymerase chain reaction primer-introduced restriction analysis, we demonstrated that goosegrass genomic DNA can be diagnosed for Drp alleles. Although not direct proof, these results suggest that a mutation in an alpha-tubulin gene confers resistance to dinitroanilines in goosegrass.

  12. Monte Carlo alpha calculation

    Energy Technology Data Exchange (ETDEWEB)

    Brockway, D.; Soran, P.; Whalen, P.

    1985-01-01

    A Monte Carlo algorithm to efficiently calculate static alpha eigenvalues, N = ne/sup ..cap alpha..t/, for supercritical systems has been developed and tested. A direct Monte Carlo approach to calculating a static alpha is to simply follow the buildup in time of neutrons in a supercritical system and evaluate the logarithmic derivative of the neutron population with respect to time. This procedure is expensive, and the solution is very noisy and almost useless for a system near critical. The modified approach is to convert the time-dependent problem to a static ..cap alpha../sup -/eigenvalue problem and regress ..cap alpha.. on solutions of a/sup -/ k/sup -/eigenvalue problem. In practice, this procedure is much more efficient than the direct calculation, and produces much more accurate results. Because the Monte Carlo codes are intrinsically three-dimensional and use elaborate continuous-energy cross sections, this technique is now used as a standard for evaluating other calculational techniques in odd geometries or with group cross sections.

  13. DETERMINATION OF MUSHROOM TOXIN ALPHA-AMANITIN IN SERUM BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY AFTER SOLID-PHASE EXTRACTION

    Directory of Open Access Journals (Sweden)

    Maja Vujović

    2015-03-01

    Full Text Available Alpha-amanitin is a cyclic peptide which belongs to a large group of mushroom toxins known as amatoxins. Being responsible for the majority of fatal mushroom poisonings, they require rapid detection and excretion from the body fluids. In accordance with these requirements, a simple and an accurate method was developed for successful identification and quantification of alpha-amanitin in serum with electrospray liquid chromatography–mass spectrometry (LC-ESI-MS after collision-induced dissociation. The method conforms to the established International Conference on Harmonization Q2A/Q2B 1996 guidelines on the validation of analytical methods. Linearity, precision, extraction recovery and stability test on blank serum spiked with alpha-amanitin and stored in different conditions met the acceptance criteria. The obtained calibration curve was linear over the concentration range 5-100 ng/mL with a lower limit of quantification (LOQ of 5 ng/mL and limit of detection (LOD of 2.5 ng/mL. The mean intra- and inter-day precision and accuracy were 6.05% and less than ±15% of nominal values, respectively. The neutral solid phase extraction with copolymer hydrophilic–lipophilic balance cartridges was found optimal for sample preparation with the mean recovery of 91.94%. The proposed method demonstrated high sensitivity and selectivity which can be useful both for clinical and forensic toxicology analysis of alpha-amanitin at low concentrations.

  14. Double mutation in eleusine indica alpha-tubulin increases the resistance of transgenic maize calli to dinitroaniline and phosphorothioamidate herbicides

    Science.gov (United States)

    Anthony; Hussey

    1999-06-01

    The repeated use of dinitroaniline herbicides on the cotton and soybean fields of the southern United States has resulted in the appearance of resistant biotypes of one of the world's worst weeds, Eleusine indica. Two biotypes have been characterized, a highly resistant (R) biotype and an intermediate resistant (I) biotype. In both cases the resistance has been attributed to a mutation in alpha-tubulin, a component of the alpha/beta tubulin dimer that is the major constituent of microtubules. We show here that the I-biotype mutation, like the R-biotype mutation shown in earlier work, can confer dinitroaniline resistance on transgenic maize calli. The level of resistance obtained is the same as that for E. indica I- or R-biotype seedlings. The combined I- and R-biotype mutations increase the herbicide tolerance of transgenic maize calli by a value close to the summation of the maximum herbicide tolerances of calli harbouring the single mutations. These data, taken together with the position of the two different mutations within the atomic structure of the alpha/beta tubulin dimer, imply that each mutation is likely to exert its effect by a different mechanism. These mechanisms may involve increasing the stability of microtubules against the depolymerizing effects of the herbicide or changing the conformation of the alpha/beta dimer so that herbicide binding is less effective, or a combination of both possibilities.

  15. Alpha particle physics experiments in the Tokamak Fusion Test Reactor

    International Nuclear Information System (INIS)

    Zweben, S.J.; Budny, R.V.; Darrow, D.S.; Medley, S.S.; Nazikian, R.; Stratton, B.C.; Synakowski, E.J.; Taylor, G.

    2000-01-01

    Alpha particle physics experiments were done on TFTR during its DT run from 1993 to 1997. These experiments utilized several new alpha particle diagnostics and hundreds of DT discharges to characterize the alpha particle confinement and wave-particle interactions. In general, the results from the alpha particle diagnostics agreed with the classical single particle confinement model in MHD quiescent discharges. The alpha loss due to toroidal field ripple was identified in some cases, and the low radial diffusivity inferred for high energy alphas was consistent with orbit averaging over small scale turbulence. Finally, the observed alpha particle interactions with sawteeth, toroidal Alfven eigenmodes and ICRF waves were approximately consistent with theoretical modelling. What was learned is reviewed and what remains to be understood is identified. (author)

  16. Micro-electrodeposition techniques for the preparation of small actinide counting sources for ultra-high resolution alpha spectrometry by microcalorimetry

    International Nuclear Information System (INIS)

    Plionis, A.A.; Hastings, E.P.; LaMont, S.P.; Dry, D.E.; Bacrania, M.K.; Rabin, M.W.; Rim, J.H.

    2009-01-01

    Special considerations and techniques are desired for the preparation of small actinide counting sources. Counting sources have been prepared on metal disk substrates (planchets) with an active area of only 0.079 mm 2 . This represents a 93.75% reduction in deposition area from standard electrodeposition methods. The actinide distribution upon the smaller planchet must remain thin and uniform to allow alpha particle emissions to escape the counting source with a minimal amount of self-attenuation. This work describes the development of micro-electrodeposition methods and optimization of the technique with respect to deposition time and current density for various planchet sizes. (author)

  17. Observation of the Identical Rigidity Dependence of He, C, and O Cosmic Rays at High Rigidities by the Alpha Magnetic Spectrometer on the International Space Station

    Science.gov (United States)

    Aguilar, M.; Ali Cavasonza, L.; Alpat, B.; Ambrosi, G.; Arruda, L.; Attig, N.; Aupetit, S.; Azzarello, P.; Bachlechner, A.; Barao, F.; Barrau, A.; Barrin, L.; Bartoloni, A.; Basara, L.; Başeǧmez-du Pree, S.; Battarbee, M.; Battiston, R.; Becker, U.; Behlmann, M.; Beischer, B.; Berdugo, J.; Bertucci, B.; Bindel, K. F.; Bindi, V.; de Boer, W.; Bollweg, K.; Bonnivard, V.; Borgia, B.; Boschini, M. J.; Bourquin, M.; Bueno, E. F.; Burger, J.; Burger, W. J.; Cadoux, F.; Cai, X. D.; Capell, M.; Caroff, S.; Casaus, J.; Castellini, G.; Cervelli, F.; Chae, M. J.; Chang, Y. H.; Chen, A. I.; Chen, G. M.; Chen, H. S.; Cheng, L.; Chou, H. Y.; Choumilov, E.; Choutko, V.; Chung, C. H.; Clark, C.; Clavero, R.; Coignet, G.; Consolandi, C.; Contin, A.; Corti, C.; Creus, W.; Crispoltoni, M.; Cui, Z.; Dadzie, K.; Dai, Y. M.; Datta, A.; Delgado, C.; Della Torre, S.; Demakov, O.; Demirköz, M. B.; Derome, L.; Di Falco, S.; Dimiccoli, F.; Díaz, C.; von Doetinchem, P.; Dong, F.; Donnini, F.; Duranti, M.; D'Urso, D.; Egorov, A.; Eline, A.; Eronen, T.; Feng, J.; Fiandrini, E.; Fisher, P.; Formato, V.; Galaktionov, Y.; Gallucci, G.; García-López, R. J.; Gargiulo, C.; Gast, H.; Gebauer, I.; Gervasi, M.; Ghelfi, A.; Giovacchini, F.; Gómez-Coral, D. M.; Gong, J.; Goy, C.; Grabski, V.; Grandi, D.; Graziani, M.; Guo, K. H.; Haino, S.; Han, K. C.; He, Z. H.; Heil, M.; Hoffman, J.; Hsieh, T. H.; Huang, H.; Huang, Z. C.; Huh, C.; Incagli, M.; Ionica, M.; Jang, W. Y.; Jia, Yi; Jinchi, H.; Kang, S. C.; Kanishev, K.; Khiali, B.; Kim, G. N.; Kim, K. S.; Kirn, Th.; Konak, C.; Kounina, O.; Kounine, A.; Koutsenko, V.; Kulemzin, A.; La Vacca, G.; Laudi, E.; Laurenti, G.; Lazzizzera, I.; Lebedev, A.; Lee, H. T.; Lee, S. C.; Leluc, C.; Li, H. S.; Li, J. Q.; Li, Q.; Li, T. X.; Li, Y.; Li, Z. H.; Li, Z. Y.; Lim, S.; Lin, C. H.; Lipari, P.; Lippert, T.; Liu, D.; Liu, Hu; Lordello, V. D.; Lu, S. Q.; Lu, Y. S.; Luebelsmeyer, K.; Luo, F.; Luo, J. Z.; Lyu, S. S.; Machate, F.; Mañá, C.; Marín, J.; Martin, T.; Martínez, G.; Masi, N.; Maurin, D.; Menchaca-Rocha, A.; Meng, Q.; Mikuni, V. M.; Mo, D. C.; Mott, P.; Nelson, T.; Ni, J. Q.; Nikonov, N.; Nozzoli, F.; Oliva, A.; Orcinha, M.; Palmonari, F.; Palomares, C.; Paniccia, M.; Pauluzzi, M.; Pensotti, S.; Perrina, C.; Phan, H. D.; Picot-Clemente, N.; Pilo, F.; Pizzolotto, C.; Plyaskin, V.; Pohl, M.; Poireau, V.; Quadrani, L.; Qi, X. M.; Qin, X.; Qu, Z. Y.; Räihä, T.; Rancoita, P. G.; Rapin, D.; Ricol, J. S.; Rosier-Lees, S.; Rozhkov, A.; Rozza, D.; Sagdeev, R.; Schael, S.; Schmidt, S. M.; Schulz von Dratzig, A.; Schwering, G.; Seo, E. S.; Shan, B. S.; Shi, J. Y.; Siedenburg, T.; Son, D.; Song, J. W.; Tacconi, M.; Tang, X. W.; Tang, Z. C.; Tescaro, D.; Ting, Samuel C. C.; Ting, S. M.; Tomassetti, N.; Torsti, J.; Türkoǧlu, C.; Urban, T.; Vagelli, V.; Valente, E.; Valtonen, E.; Vázquez Acosta, M.; Vecchi, M.; Velasco, M.; Vialle, J. P.; Vitale, V.; Vitillo, S.; Wang, L. Q.; Wang, N. H.; Wang, Q. L.; Wang, X.; Wang, X. Q.; Wang, Z. X.; Wei, C. C.; Weng, Z. L.; Whitman, K.; Wu, H.; Wu, X.; Xiong, R. Q.; Xu, W.; Yan, Q.; Yang, J.; Yang, M.; Yang, Y.; Yi, H.; Yu, Y. J.; Yu, Z. Q.; Zannoni, M.; Zeissler, S.; Zhang, C.; Zhang, F.; Zhang, J.; Zhang, J. H.; Zhang, S. W.; Zhang, Z.; Zheng, Z. M.; Zhuang, H. L.; Zhukov, V.; Zichichi, A.; Zimmermann, N.; Zuccon, P.; AMS Collaboration

    2017-12-01

    We report the observation of new properties of primary cosmic rays He, C, and O measured in the rigidity (momentum/charge) range 2 GV to 3 TV with 90 ×106 helium, 8.4 ×106 carbon, and 7.0 ×106 oxygen nuclei collected by the Alpha Magnetic Spectrometer (AMS) during the first five years of operation. Above 60 GV, these three spectra have identical rigidity dependence. They all deviate from a single power law above 200 GV and harden in an identical way.

  18. AINSE's 40th anniversary conference. Conference handbook

    International Nuclear Information System (INIS)

    1998-01-01

    Highlights of 40 years of activity of the Australian Institute of Nuclear Science and Engineering (AINSE) were the main focus of this conference. Topics covered include nuclear physics, plasma physics, radiation chemistry, radiation biology, neutron diffraction, nuclear techniques of analysis and other relevant aspects of nuclear science and technology. The conference handbook contains the summaries of the 78 papers and posters presented and the list of participants

  19. History of NAMES Conferences

    Science.gov (United States)

    Filippov, Lev

    2013-03-01

    -Russian International Centre was demonstrated. By the high standards of the reports presented, as well as by its overall organization, the second Seminar met the standards of an international conference. Reviews of state-of-the-art developments in materials science were given by leading scientists from Moscow and from the Lorraine region. The three days of the seminar were structured into four main themes: Functional Materials Coatings, Films and Surface Engineering Nanomaterials and Nanotechnologies The Environment and three Round Table discussions: Defining practical means of carrying out Franco-Russian collaborations in technology transfer and innovation Materials science ARCUS: Lorraine-Russian collaboration in materials science and the environment 32 oral and 25 poster presentations within four sections were given by a total of 110 participants. NAMES 2007, the 3rd Franco-Russian Seminar on New Achievements in Materials and Environmental Sciences, took place in Metz, France on 7-9 November 2007. The conference highlights fundamentals and development of the five main themes connected to the Lorraine-Russia ARCUS project with possible extension to other topics. The five main subjects included in the ARCUS project are: Bulk-surface-interface material sciences Nanomaterials and nanotechnologies Environment and natural resources Plasma physics—ITER project Vibrational dynamics The first, second and third NAMES conferences were financially supported by the following organizations: Ambassade de France à Moscou Communauté Urbaine du Grand Nancy Région Lorraine Conseil Général de Meurthe et Moselle Institut National Polytechnique de Lorraine Université de Metz Université Henry Poincaré CNRS ANVAR Federal Agency on Science and Innovations of the Ministry of Education and Science of the Russian Federation Moscow Committee on Science and Technologies Moscow Institute of Steel and Alloys (Technological University) The 4th conference is supported by the Ministry of Foreign Affairs of

  20. 2nd International Conference on Photonics, Optics and Laser Technology

    CERN Document Server

    Raposo, Maria

    2016-01-01

    This collection of the selected papers presented to the Second International Conference on Photonics, Optics and laser technology PHOTOPTICS 2014 covers the three main conference scientific areas of “Optics”, “Photonics” and “Lasers”. The selected papers, in two classes full and short, result from a double blind review carried out by conference Program Committee members who are highly qualified experts in the conference topic areas.