WorldWideScience

Sample records for high administrative costs

  1. 45 CFR 96.88 - Administrative costs.

    Science.gov (United States)

    2010-10-01

    ... Assistance Program § 96.88 Administrative costs. (a) Costs of planning and administration. Any expenditure... 45 Public Welfare 1 2010-10-01 2010-10-01 false Administrative costs. 96.88 Section 96.88 Public... be included in determining administrative costs subject to the statutory limitation on...

  2. 我国地方政府行政成本过高问题及对策%High administrative costs of local government problems and countermeasures

    Institute of Scientific and Technical Information of China (English)

    田丰

    2014-01-01

    解决地方政府行政成本过高的问题已经成为当前行政体制改革的重要内容。本文先从行政成本的概念界定入手,接着罗列出当前我国地方政府行政成本过高问题的具体表现,然后分析这一问题产生的原因,最后提出解决对策。%Local government to solve the problem of high administrative costs has become an important part of administrative reform. Firstly,this paper defines the concept of administrative costs, then set out the specific performance of the current high cost of local government administration issues, and then analyze the causes of the problems, and finally propose countermeasures.

  3. 24 CFR 583.135 - Administrative costs.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Administrative costs. 583.135... (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND... Administrative costs. (a) General. Up to five percent of any grant awarded under this part may be used for...

  4. 47 CFR 52.17 - Costs of number administration.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Costs of number administration. 52.17 Section... (CONTINUED) NUMBERING Administration § 52.17 Costs of number administration. All telecommunications carriers... efficient administration of the number administration cost recovery. (c) For the purposes of this...

  5. Administration costs of intravenous biologic drugs for rheumatoid arthritis

    OpenAIRE

    Soini, Erkki J.; Leussu, Miina; Hallinen, Taru

    2013-01-01

    Background Cost-effectiveness studies explicitly reporting infusion times, drug-specific administration costs for infusions or real-payer intravenous drug cost are few in number. Yet, administration costs for infusions are needed in the health economic evaluations assessing intravenously-administered drugs. Objectives To estimate the drug-specific administration and total cost of biologic intravenous rheumatoid arthritis (RA) drugs in the adult population and to compare the obtained costs wit...

  6. 18 CFR 11.1 - Costs of administration.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Costs of administration... ACT Charges for Costs of Administration, Use of Tribal Lands and Other Government Lands, and Use of Government Dams § 11.1 Costs of administration. (a) Authority. Pursuant to section 10(e) of the Federal...

  7. 24 CFR 1003.206 - Program administration costs.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Program administration costs. 1003... Eligible Activities § 1003.206 Program administration costs. ICDBG funds may be used for the payment of... to undertake a specific funded activity are also not considered program administration costs....

  8. 24 CFR 92.207 - Eligible administrative and planning costs.

    Science.gov (United States)

    2010-04-01

    ... planning costs. 92.207 Section 92.207 Housing and Urban Development Office of the Secretary, Department of... Prohibited Activities § 92.207 Eligible administrative and planning costs. A participating jurisdiction may expend, for payment of reasonable administrative and planning costs of the HOME program and ADDI, an...

  9. 5 CFR 179.214 - Interest, penalties and administrative costs.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Interest, penalties and administrative costs. 179.214 Section 179.214 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Salary Offset § 179.214 Interest, penalties and administrative...

  10. 24 CFR 1006.230 - Administrative and planning costs.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Administrative and planning costs... Administrative and planning costs. Up to such amount as HUD may authorize, or such other limit as may be... planning expenses of the DHHL relating to carrying out the Act and this part and activities assisted with...

  11. 7 CFR 277.9 - Administrative costs principles.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administrative costs principles. 277.9 Section 277.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... AGENCIES § 277.9 Administrative costs principles. (a) This section prescribes specific policies...

  12. Tax-tariff reform with costs of tax administration

    DEFF Research Database (Denmark)

    Munk, Knud Jørgen

    on border taxes to finance its resource requirements. However, the theorem does not hold when taxation is associated with administrative costs. The present paper explores the implications of taking into account the costs of tax administration for optimal taxation and for desirable directions of tax...

  13. Tax-tariff reform with costs of tax administration

    DEFF Research Database (Denmark)

    Munk, Knud Jørgen

    on border taxes to finance its resource requirements. However, the theorem does not hold when taxation is associated with administrative costs. The present paper explores the implications of taking into account the costs of tax administration for optimal taxation and for desirable directions of tax...

  14. Vote Centers as a Strategy to Control Election Administration Costs

    Directory of Open Access Journals (Sweden)

    David H. Folz

    2014-03-01

    Full Text Available The rising costs of election administration in an era of fiscal stress have motivated some local officials to test the feasibility of ideas for reducing election costs while enhancing voter convenience and perhaps even increasing voter turnout. One such pilot project in a suburban community in the South involved replacing precinct-based voting on election day with a vote center that all voters could use regardless of their precinct of residence. A comparison of election costs across two municipal elections showed that replacing precinct-based voting with an election day vote center resulted in substantial cost savings. While there was no statistical difference in voter turnout in municipal elections held before and after implementation of the pilot project, voters were highly satisfied with the convenience of the vote center as well as other aspects of their voting experience. The findings suggest that an election day vote center can be a viable strategy to control election costs and enhance voters’ perceptions of the convenience of voting.

  15. Cost-minimization of mabthera intravenous versus subcutaneous administration

    NARCIS (Netherlands)

    Bax, P.; Postma, M.J.

    2013-01-01

    Objectives: To identify and compare all costs related to preparing and administrating MabThera for the intravenous and subcutaneous formulations in Dutch hematological patients. The a priori notion is that the costs of subcutaneous MabThera injections are lower compared to intravenous infusion due t

  16. Cost-minimization of mabthera intravenous versus subcutaneous administration

    NARCIS (Netherlands)

    Bax, P.; Postma, M.J.

    2013-01-01

    Objectives: To identify and compare all costs related to preparing and administrating MabThera for the intravenous and subcutaneous formulations in Dutch hematological patients. The a priori notion is that the costs of subcutaneous MabThera injections are lower compared to intravenous infusion due

  17. 77 FR 69441 - Federal Acquisition Regulation; Information Collection; Cost Accounting Standards Administration

    Science.gov (United States)

    2012-11-19

    ... Regulation; Information Collection; Cost Accounting Standards Administration AGENCY: Department of Defense... approved information collection requirement concerning cost accounting standards administration. Public... comments identified by Information Collection 9000- 0129, Cost Accounting Standards Administration by...

  18. Of Dirty Sheets and Worse: Administration Costs and Staffing Matters.

    Science.gov (United States)

    Keigher, Sharon M.

    1993-01-01

    Considers article written by professor of social welfare in 1981 in which job security of social workers is addressed. Compares views expressed in 1981 with situation faced by social workers today. Considers danger of administration costs resulting in short-staffing of hospitals serving the poor and discusses case of 22-year-old obstetrics patient…

  19. 31 CFR 901.9 - Interest, penalties, and administrative costs.

    Science.gov (United States)

    2010-07-01

    ... and loan guaranties. The cost of living adjustment is the percentage by which the Consumer Price Index for the month of June of the calendar year preceding the adjustment exceeds the Consumer Price Index.... Increases to administrative debts shall be computed annually. Agencies should use this alternative only...

  20. National mass drug administration costs for lymphatic filariasis elimination.

    Directory of Open Access Journals (Sweden)

    Ann S Goldman

    Full Text Available BACKGROUND: Because lymphatic filariasis (LF elimination efforts are hampered by a dearth of economic information about the cost of mass drug administration (MDA programs (using either albendazole with diethylcarbamazine [DEC] or albendazole with ivermectin, a multicenter study was undertaken to determine the costs of MDA programs to interrupt transmission of infection with LF. Such results are particularly important because LF programs have the necessary diagnostic and treatment tools to eliminate the disease as a public health problem globally, and already by 2006, the Global Programme to Eliminate LF had initiated treatment programs covering over 400 million of the 1.3 billion people at risk. METHODOLOGY/PRINCIPAL FINDINGS: To obtain annual costs to carry out the MDA strategy, researchers from seven countries developed and followed a common cost analysis protocol designed to estimate 1 the total annual cost of the LF program, 2 the average cost per person treated, and 3 the relative contributions of the endemic countries and the external partners. Costs per person treated ranged from $0.06 to $2.23. Principal reasons for the variation were 1 the age (newness of the MDA program, 2 the use of volunteers, and 3 the size of the population treated. Substantial contributions by governments were documented - generally 60%-90% of program operation costs, excluding costs of donated medications. CONCLUSIONS/SIGNIFICANCE: MDA for LF elimination is comparatively inexpensive in relation to most other public health programs. Governments and communities make the predominant financial contributions to actual MDA implementation, not counting the cost of the drugs themselves. The results highlight the impact of the use of volunteers on program costs and provide specific cost data for 7 different countries that can be used as a basis both for modifying current programs and for developing new ones.

  1. A Comparison Of Hospital Administrative Costs In Eight Nations: US Costs Exceed All Others By Far

    NARCIS (Netherlands)

    Himmelstein, D.U.; Jun, M.; Busse, R.; Chevreul, K.; Geissler, A.; Jeurissen, P.P.T.; Thomson, S.; Vinet, M.A.; Woolhandler, S.

    2014-01-01

    A few studies have noted the outsize administrative costs of US hospitals, but no research has compared these costs across multiple nations with various types of health care systems. We assembled a team of international health policy experts to conduct just such a challenging analysis of hospital

  2. Ultra High Brightness/Low Cost Fiber Coupled Packaging Project

    Data.gov (United States)

    National Aeronautics and Space AdministrationHigh peak power, high efficiency, high reliability lightweight, low cost QCW laser diode pump modules with up to 1000W of QCW output become possible with nLight's...

  3. 34 CFR 363.51 - What are the allowable administrative costs?

    Science.gov (United States)

    2010-07-01

    ... administrative costs? (a) Administrative costs—general. Expenditures are allowable for the following administrative costs: (1) Administration of the State plan supplement for this program. (2) Planning program... 34 Education 2 2010-07-01 2010-07-01 false What are the allowable administrative costs?...

  4. 36 CFR 1206.45 - What rules govern subgrant distribution, cost sharing, grant administration, and reporting?

    Science.gov (United States)

    2010-07-01

    ... distribution, cost sharing, grant administration, and reporting? 1206.45 Section 1206.45 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION GENERAL RULES NATIONAL HISTORICAL..., cost sharing, grant administration, and reporting? (a) The Commission will annually establish...

  5. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What types of costs are subject to the administrative cost limit on Tribal Family Assistance Grant funds? 286.55 Section 286.55 Public Welfare... § 286.55 What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

  6. 76 FR 51029 - Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron...

    Science.gov (United States)

    2011-08-17

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron... proposed administrative settlement for recovery of past response costs concerning the Carpenter Avenue.... Comments should reference the Carpenter Avenue Mercury site, Iron Mountain, Dickenson County, Michigan...

  7. 78 FR 20393 - Cost Recovery for Permit Processing, Administration, and Enforcement

    Science.gov (United States)

    2013-04-04

    ... CFR Parts 701, 736, 737 et al. Cost Recovery for Permit Processing, Administration, and Enforcement... Parts 701, 736, 737, 738, and 750 RIN 1029-AC65 Cost Recovery for Permit Processing, Administration, and... inspection), and the differing costs for the administration of the Federal and Indian Land Programs among...

  8. 78 FR 18429 - Cost Recovery for Permit Processing, Administration, and Enforcement

    Science.gov (United States)

    2013-03-26

    ... 30 CFR Parts 701, 736, 737 et al. Cost Recovery for Permit Processing, Administration, and... 701, 736, 737, 738, and 750 RIN 1029-AC65 Cost Recovery for Permit Processing, Administration, and... fees to recover the actual costs for permit review and administration and permit enforcement...

  9. 48 CFR 52.230-6 - Administration of Cost Accounting Standards.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Administration of Cost... Clauses 52.230-6 Administration of Cost Accounting Standards. As prescribed in 30.201-4(d)(1), insert the following clause: Administration of Cost Accounting Standards (JUN 2010) For the purpose of...

  10. 42 CFR 417.564 - Apportionment and allocation of administrative and general costs.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Apportionment and allocation of administrative and... Apportionment and allocation of administrative and general costs. (a) Costs not directly associated with... administrative and general costs that are not included in paragraph (a) of this section. (2) The allocation...

  11. 26 CFR 301.7430-2 - Requirements and procedures for recovery of reasonable administrative costs.

    Science.gov (United States)

    2010-04-01

    ... administrative proceeding, then an affidavit that specialized skills and distinctive knowledge as described in... reasonable administrative costs. 301.7430-2 Section 301.7430-2 Internal Revenue INTERNAL REVENUE SERVICE... reasonable administrative costs. (a) Introduction. Section 7430(a)(1) provides for the recovery, under...

  12. 24 CFR 1003.501 - Applicability of uniform administrative requirements and cost principles.

    Science.gov (United States)

    2010-04-01

    ... administrative requirements and cost principles. 1003.501 Section 1003.501 Housing and Urban Development... TRIBES AND ALASKA NATIVE VILLAGES Grant Administration § 1003.501 Applicability of uniform administrative requirements and cost principles. (a) Grantees and subrecipients which are governmental entities...

  13. The Program Administrator Cost of Saved Energy for Utility Customer-Funded Energy Efficiency Programs

    Energy Technology Data Exchange (ETDEWEB)

    Billingsley, Megan A.; Hoffman, Ian M.; Stuart, Elizabeth; Schiller, Steven R.; Goldman, Charles A.; LaCommare, Kristina

    2014-03-19

    End-use energy efficiency is increasingly being relied upon as a resource for meeting electricity and natural gas utility system needs within the United States. There is a direct connection between the maturation of energy efficiency as a resource and the need for consistent, high-quality data and reporting of efficiency program costs and impacts. To support this effort, LBNL initiated the Cost of Saved Energy Project (CSE Project) and created a Demand-Side Management (DSM) Program Impacts Database to provide a resource for policy makers, regulators, and the efficiency industry as a whole. This study is the first technical report of the LBNL CSE Project and provides an overview of the project scope, approach, and initial findings, including: • Providing a proof of concept that the program-level cost and savings data can be collected, organized, and analyzed in a systematic fashion; • Presenting initial program, sector, and portfolio level results for the program administrator CSE for a recent time period (2009-2011); and • Encouraging state and regional entities to establish common reporting definitions and formats that would make the collection and comparison of CSE data more reliable. The LBNL DSM Program Impacts Database includes the program results reported to state regulators by more than 100 program administrators in 31 states, primarily for the years 2009–2011. In total, we have compiled cost and energy savings data on more than 1,700 programs over one or more program-years for a total of more than 4,000 program-years’ worth of data, providing a rich dataset for analyses. We use the information to report costs-per-unit of electricity and natural gas savings for utility customer-funded, end-use energy efficiency programs. The program administrator CSE values are presented at national, state, and regional levels by market sector (e.g., commercial, industrial, residential) and by program type (e.g., residential whole home programs, commercial new

  14. 47 CFR 24.241 - Administration of the Cost-Sharing Plan.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Administration of the Cost-Sharing Plan. 24.241... Mhz Band § 24.241 Administration of the Cost-Sharing Plan. The Wireless Telecommunications Bureau.... This clearinghouse will administer the cost-sharing plan by, inter alia, maintaining all of the...

  15. 47 CFR 27.1178 - Administration of the Cost-Sharing Plan.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Administration of the Cost-Sharing Plan. 27... Cost-Sharing Policies Governing Broadband Radio Service Relocation from the 2150-2160/62 Mhz Band § 27.1178 Administration of the Cost-Sharing Plan. The Wireless Telecommunications Bureau, under...

  16. 47 CFR 27.1162 - Administration of the Cost-Sharing Plan.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Administration of the Cost-Sharing Plan. 27... Cost-Sharing Policies Governing Microwave Relocation from the 2110-2150 Mhz and 2160-2200 Mhz Bands § 27.1162 Administration of the Cost-Sharing Plan. The Wireless Telecommunications Bureau,...

  17. Impacts on irrigated agriculture of changes in electricity costs resulting from Western Area Power Administration`s power marketing alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, B.K.; Flaim, S.J.; Howitt, R.E. [Argonne National Lab., IL (United States); Palmer, S.C. [Western Area Power Administration, Salt Lake City, UT (United States)

    1995-03-01

    Irrigation is a major factor in the growth of US agricultural productivity, especially in western states, which account for more than 85% of the nation`s irrigated acreage. In some of these states, almost all cropland is irrigated, and nearly 50% of the irrigation is done with electrically powered pumps. Therefore, even small increases in the cost of electricity could have a disproportionate impact on irrigated agriculture. This technical memorandum examines the impacts that could result from proposed changes in the power marketing programs of the Western Area Power Administration`s Salt Lake City Area Office. The changes could increase the cost of power to all Western customers, including rural municipalities and irrigation districts that rely on inexpensive federal power to pump water. The impacts are assessed by translating changes in Western`s wholesale power rate into changes in the cost of pumping water as an input for agricultural production. Farmers can adapt to higher electricity prices in many ways, such as (1) using different pumping fuels, (2) adding workers and increasing management to irrigate more efficiently, and (3) growing more drought-tolerant crops. This study projects several responses, including using less groundwater and planting fewer waterintensive crops. The study finds that when dependence on Western`s power is high, the cost of power can have a major effect on energy use, agricultural practices, and the distribution of planted acreage. The biggest percentage changes in farm income would occur (1) in Nevada and Utah (however, all projected changes are less than 2% of the baseline) and (2) under the marketing alternatives that represent the lowest capacity and energy offer considered in Western`s Electric Power Marketing Environmental Impact Statement. The aggregate impact on farm incomes and the value of total farm production would be much smaller than that suggested by the changes in water use and planted acreage.

  18. Thinking on the High Undesirable Administrative Costs of Chinese Government---Reflection on the Junket ofPublic Servants in China%中国政府不良行政成本偏高的制度思考--对我国公务人员公费旅游的反思

    Institute of Scientific and Technical Information of China (English)

    王明杰

    2016-01-01

    The relationship between state and society,government and citizen reflected in the administrative costs determines its significance in public affairs.Whether the administrative costs is reasonable or not is directly related to the credibility of the government as well as the legitimacy of the regime.This study divides the administrative costs into “necessary administrative costs”and “undesirable administrative costs”,starts from the defects of the current system of public servants out learning in our country,has deep reflection on the cause of the high undesirable administrative costs and explore the solutions in terms of system to reduce the administrative costs and improve administrative efficiency .%行政成本所内含的国家与社会、政府与公民关系决定了其在公共事务中的重要意义,行政成本合理与否将直接关系到政府的公信力以及政权的合法性。文章将行政成本分为“必须行政成本”和“不良行政成本”,从我国现行公务人员外出学习考察体制的制度缺陷着手,对不良行政成本偏高的原因进行深层次的反思,探寻降低行政成本,提高行政效率的制度上的解法。

  19. Social Security Administration Data for Extra Help with Medicare Prescription Drug Plan Cost

    Data.gov (United States)

    Social Security Administration — This file contains information about Social Security determinations of eligibility for Extra Help with Medicare Prescription Drug Plan Costs. Specific data elements...

  20. Cost-effectiveness analysis in markets with high fixed costs.

    Science.gov (United States)

    Cutler, David M; Ericson, Keith M Marzilli

    2010-01-01

    We consider how to conduct cost-effectiveness analysis when the social cost of a resource differs from the posted price. From the social perspective, the true cost of a medical intervention is the marginal cost of delivering another unit of a treatment, plus the social cost (deadweight loss) of raising the revenue to fund the treatment. We focus on pharmaceutical prices, which have high markups over marginal cost due to the monopoly power granted to pharmaceutical companies when drugs are under patent. We find that the social cost of a branded drug is approximately one-half the market price when the treatment is paid for by a public insurance plan and one-third the market price for mandated coverage by private insurance. We illustrate the importance of correctly accounting for social costs using two examples: coverage for statin drugs and approval for a drug to treat kidney cancer (sorafenib). In each case, we show that the correct social perspective for cost-effectiveness analysis would be more lenient than researcher recommendations.

  1. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Science.gov (United States)

    2010-10-01

    ... and General Administration § 1301.32 Limitations on costs of development and administration of a Head... the costs for development and administration are at or below 15 percent, but are judged by the... the portion of the costs that are for development and administration. (2) Dual benefit costs...

  2. School District Administrative Costs, Regional Series, and Telecommunications. Special Study. Report to the Arizona Legislature by the Auditor General.

    Science.gov (United States)

    Arizona State Dept. of Education, Phoenix.

    The Arizona Office of the Auditor General conducted a study of Arizona school district administrative costs, regional services, and telecommunications. In the area of administrative costs, the study found that larger, unified districts were more cost effective in terms of district administrative costs per student and students per administrator.…

  3. 25 CFR 122.8 - Administrative costs for management of the fund.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Administrative costs for management of the fund. 122.8 Section 122.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES MANAGEMENT OF OSAGE JUDGMENT FUNDS FOR EDUCATION § 122.8 Administrative costs for management of the fund. Funds...

  4. 76 FR 64943 - Proposed Cercla Administrative Cost Recovery Settlement; ACM Smelter and Refinery Site, Located...

    Science.gov (United States)

    2011-10-19

    ... AGENCY Proposed Cercla Administrative Cost Recovery Settlement; ACM Smelter and Refinery Site, Located in... administrative settlement for recovery of past and projected future response costs concerning the ACM Smelter and...-5027. Comments should reference the ACM Smelter and Refinery NPL Site, the EPA Docket No....

  5. 76 FR 71342 - Proposed CERCLA Administrative Cost Recovery Settlement; River Forest Dry Cleaners Site, River...

    Science.gov (United States)

    2011-11-17

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; River Forest Dry Cleaners Site, River... proposed administrative settlement for recovery of past response costs concerning the River Forest Dry Cleaners site in River Forest, Cook County, Illinois with the following settling party: Edward...

  6. 24 CFR 570.610 - Uniform administrative requirements and cost principles.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Uniform administrative requirements and cost principles. 570.610 Section 570.610 Housing and Urban Development Regulations Relating to... GRANTS Other Program Requirements § 570.610 Uniform administrative requirements and cost principles....

  7. 34 CFR 690.10 - Administrative cost allowance to participating schools.

    Science.gov (United States)

    2010-07-01

    ... General Definitions § 690.10 Administrative cost allowance to participating schools. (a) Subject to... 34 Education 3 2010-07-01 2010-07-01 false Administrative cost allowance to participating schools. 690.10 Section 690.10 Education Regulations of the Offices of the Department of Education...

  8. 31 CFR Appendix I(f) to Part 13 - Estimated Overhead and Administrative Costs

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Estimated Overhead and Administrative Costs I(F) Appendix I(F) to Part 13 Money and Finance: Treasury Office of the Secretary of the Treasury... Pt. 13, App. I(F) Appendix I(F) to Part 13—Estimated Overhead and Administrative Costs Date:...

  9. 7 CFR 1219.52 - Control of administrative costs.

    Science.gov (United States)

    2010-01-01

    ....52 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS... Board shall implement a system of cost controls based on normally accepted business practices to:...

  10. Optimal administrative scale for planning public services: a social cost model applied to Flemish hospital care.

    Science.gov (United States)

    Blank, Jos L T; van Hulst, Bart

    2015-01-01

    In choosing the scale of public services, such as hospitals, both economic and public administrative considerations play important roles. The scale and the corresponding spatial distribution of public institutions have consequences for social costs, defined as the institutions' operating costs and the users' travel costs (which include the money and time costs). Insight into the relationship between scale and spatial distribution and social costs provides a practical guide for the best possible administrative planning level. This article presents a purely economic model that is suitable for deriving the optimal scale for public services. The model also reveals the corresponding optimal administrative planning level from an economic perspective. We applied this model to hospital care in Flanders for three different types of care. For its application, we examined the social costs of hospital services at different levels of administrative planning. The outcomes show that the social costs of rehabilitation in Flanders with planning at the urban level (38 areas) are 11% higher than those at the provincial level (five provinces). At the regional level (18 areas), the social costs of rehabilitation are virtually equal to those at the provincial level. For radiotherapy, there is a difference of 88% in the social costs between the urban and the provincial level. For general care, there are hardly any cost differences between the three administrative levels. Thus, purely from the perspective of social costs, rehabilitation should preferably be planned at the regional level, general services at the urban level and radiotherapy at the provincial level.

  11. 34 CFR 461.40 - What are the State and local administrative costs requirements?

    Science.gov (United States)

    2010-07-01

    ... remainder may be used for local administrative costs—noninstructional expenses, including planning... administrative cost limits under paragraph (b)(2) of this section are insufficient for adequate planning... 34 Education 3 2010-07-01 2010-07-01 false What are the State and local administrative...

  12. 10 CFR 1015.212 - Interest, penalties and administrative costs.

    Science.gov (United States)

    2010-01-01

    ... percentage by which the Consumer Price Index for the month of June of the calendar year preceding the adjustment exceeds the Consumer Price Index for the month of June of the calendar year in which the debt was determined or last adjusted. Increases to administrative debts shall be computed annually. DOE will use...

  13. Pareto Optimal Insurance Policies in the Presence of Administrative Costs

    OpenAIRE

    Aase, Knut K.

    2010-01-01

    In his classical article in The American Economic Review, Arthur Raviv (1979) examines Pareto optimal insurance contracts when there are ex-post insurance costs c induced by the indemnity I for loss x. Raviv’s main result is that a necessary and sufficient condition for the Pareto optimal deductible to be equal to zero is c0(I) = 0 for all I > 0(or I=0). We claim that another type of cost function is called for in household insurance, caused by frequent but relatively small ...

  14. 76 FR 54223 - Notice of Proposed Administrative Cost Recovery Settlement Pursuant to the Comprehensive...

    Science.gov (United States)

    2011-08-31

    ... for the Recovery of Past Costs in the Matter of Marine Corps Logistics Base, Yermo Annex, Barstow... Department of the Navy Notice of Proposed Administrative Cost Recovery Settlement Pursuant to the Comprehensive Environmental Response, Compensation and Liability Act For Response Costs Incurred at Marine Corps...

  15. 7 CFR 3.17 - Interest, penalties, and administrative costs.

    Science.gov (United States)

    2010-01-01

    .... The cost of living adjustment is the percentage by which the Consumer Price Index for the month of June of the calendar year preceding the adjustment exceeds the Consumer Price Index for the month of... collection of these charges is against equity and good conscience or is not in the best interest of the...

  16. Teachers' and Administrators' Perceptions of Knowledge Management Competence of High School Administrators

    Science.gov (United States)

    Memisoglu, Salih Pasa

    2016-01-01

    This study aims to determine the teachers' and administrators' perceptions of knowledge management competence in high school administration. The study was conducted using the screening model and the study group consisted of 162 teachers and 35 administrators working at eight high schools in Turkey. Administrators' knowledge management competence…

  17. The Stickiness of Selling, General, and Administrative Costs in the Indonesian Companies

    Directory of Open Access Journals (Sweden)

    Benny Armanto

    2014-04-01

    Full Text Available Selling, general and administration costs are the main components in the Income Statement. A large number of permanent staff in sales and marketing department will make the company dominated by the fixed costs. This fact could lead to sticky cost behavior. In addition, role of the manager can also cause the cost stickiness. When the company’s revenue decreases, manager may delay to decrease the cost or not even decrease cost at all. The objective of the study is to determine whether cost stickiness of selling, general and administrative in the Indonesian listed companies. This study applied log-linear data panel regression with 3605 firm years that is listed in Indonesian Stock Exchange (BEI from 1993 – 2013. This study finds that selling, general, and administrative costs are sticky only for the manufacturing companies. Furthermore, the results show that adjustment of sales, general, and administrative costs delayed by the manager when revenue decreases, yet the cost stickiness will be reduced in the next period.

  18. 77 FR 42310 - Proposed CERCLA Administrative Cost Recovery Settlement; City of Middletown, CT and RLO...

    Science.gov (United States)

    2012-07-18

    ..., Inc., Omo Manufacturing Site, Middletown, CT AGENCY: Environmental Protection Agency. ACTION: Notice... administrative settlement for recovery of response costs under CERCLA, concerning the Omo Manufacturing Superfund... the Omo Manufacturing Superfund Site in Middletown, Connecticut with the following settling parties...

  19. 76 FR 39401 - Proposed CERCLA Administrative Cost Recovery Settlement Agreement; Textron Inc., Whittaker...

    Science.gov (United States)

    2011-07-06

    ... From the Federal Register Online via the Government Publishing Office ] ENVIRONMENTAL PROTECTION AGENCY Proposed CERCLA Administrative Cost Recovery Settlement Agreement; Textron Inc., Whittaker... Concord, Middlesex County, Massachusetts with Textron Inc., Whittaker Corporation, United States Army,...

  20. 76 FR 26291 - Proposed CERCLA AdministrativeCost Recovery” Settlement; the Doe Run Resources Corporation

    Science.gov (United States)

    2011-05-06

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed CERCLA Administrative ``Cost Recovery'' Settlement; the Doe Run Resources Corporation.... Francois Mining Area, St. Francois County, Missouri with the following settling party: The Doe...

  1. 75 FR 34448 - Proposed CERCLA Administrative Cost Recovery Settlement; Great Lakes Container Corporation...

    Science.gov (United States)

    2010-06-17

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Great Lakes Container Corporation... Lakes Container Corporation Superfund Site, located in Coventry Rhode Island with the settling parties...-1216. Comments should reference the Great Lakes Container Corporation Superfund Site, Coventry,...

  2. 20 CFR 641.856 - What functions and activities constitute costs of administration?

    Science.gov (United States)

    2010-04-01

    ..., including: (i) Accounting, budgeting, financial, and cash management functions; (ii) Procurement and... ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT PROGRAM... the direct provision of programmatic services specified in § 641.864. These costs may be...

  3. 78 FR 74128 - Proposed CERCLA Administrative Cost Recovery Settlement; Cadie Auto Salvage Site, Belvidere...

    Science.gov (United States)

    2013-12-10

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Cadie Auto Salvage Site, Belvidere, Boone... recovery of past response costs concerning the Cadie Auto Salvage Site in Belvidere, Boone County, Illinois... Facility; and Defense Logistics Agency. The settlement requires the non-owner Settling Parties to pay a...

  4. 75 FR 3236 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2010-01-20

    ... and the provision at 52.230-5 include pertinent rules and regulations related to the Cost Accounting... Regulation; Submission for OMB Review; Cost Accounting Standards Administration AGENCIES: Department of...-0129). SUMMARY: Under the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35),...

  5. 78 FR 77673 - Proposed CERCLA Administrative Cost Recovery Settlement; Cadie Auto Salvage Site, Belvidere...

    Science.gov (United States)

    2013-12-24

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Cadie Auto Salvage Site, Belvidere, Boone... recovery of past response costs concerning the Cadie Auto Salvage Site in Belvidere, Boone County, Illinois..., Illinois 60604. Comments should reference the Cadie Auto Salvage Site, Belvidere, Boone County,...

  6. Process-Based Governance in Public Administrations Using Activity-Based Costing

    Science.gov (United States)

    Becker, Jörg; Bergener, Philipp; Räckers, Michael

    Decision- and policy-makers in public administrations currently lack on missing relevant information for sufficient governance. In Germany the introduction of New Public Management and double-entry accounting enable public administrations to get the opportunity to use cost-centered accounting mechanisms to establish new governance mechanisms. Process modelling in this case can be a useful instrument to help the public administrations decision- and policy-makers to structure their activities and capture relevant information. In combination with approaches like Activity-Based Costing, higher management level can be supported with a reasonable data base for fruitful and reasonable governance approaches. Therefore, the aim of this article is combining the public sector domain specific process modelling method PICTURE and concept of activity-based costing for supporting Public Administrations in process-based Governance.

  7. Low Cost Automated Manufacture of High Efficiency THINS ZTJ PV Blanket Technology (P-NASA12-007) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA needs lower cost solar arrays with high performance for a variety of missions. While high efficiency, space-qualified solar cells are in themselves costly, >...

  8. Homeownership in a high-cost region

    OpenAIRE

    Esther Schlorholtz

    2006-01-01

    A perfect storm is brewing in eastern Massachusetts: high home prices, rising interest rates, and a proliferation of high-cost mortgage products. More buyer education and better state regulation of lenders not covered by the Community Reinvestment Act are needed.

  9. The cost of antibiotic mass drug administration for trachoma control in a remote area of South Sudan.

    Directory of Open Access Journals (Sweden)

    Jan H Kolaczinski

    2011-10-01

    Full Text Available BACKGROUND: Mass drug administration (MDA of antibiotics is a key component of the so-called "SAFE" strategy for trachoma control, while MDA of anthelminthics provides the cornerstone for control of a number of other neglected tropical diseases (NTDs. Simultaneous delivery of two or more of these drugs, renowned as "integrated NTD control," is being promoted to reduce costs and expand intervention coverage. A cost analysis was conducted alongside an MDA campaign in a remote trachoma endemic area, to inform budgeting for NTD control in South Sudan. METHODS AND FINDINGS: A first round of antibiotic MDA was conducted in the highly trachoma endemic county of Mayom, Unity state, from June to August 2010. A core team of seven staff delivered the intervention, including recruitment and training of 44 supervisors and 542 community drug distributors. Using an ingredients approach, financial and economic costs were captured from the provider perspective in a detailed costing database. Overall, 123,760 individuals were treated for trachoma, resulting in an estimated treatment coverage of 94%. The economic cost per person treated was USD 1.53, excluding the cost of the antibiotic azithromycin. Ninety four per cent of the delivery costs were recurrent costs, with personnel and travel/transport costs taking up the largest share. CONCLUSIONS: In a remote setting and for the initial round, MDA of antibiotics was considerably more expensive than USD 0.5 per person treated, an estimate frequently quoted to advocate for integrated NTD control. Drug delivery costs in South Sudan are unlikely to decrease substantially during subsequent MDA rounds, as the major cost drivers were recurrent costs. MDA campaigns for delivery of one or more drugs in South Sudan should thus be budgeted at around USD 1.5 per person treated, at least until further costing data for delivery of other NTD drugs, singly or in combination, are available.

  10. The cost of antibiotic mass drug administration for trachoma control in a remote area of South Sudan.

    Science.gov (United States)

    Kolaczinski, Jan H; Robinson, Emily; Finn, Timothy P

    2011-10-01

    Mass drug administration (MDA) of antibiotics is a key component of the so-called "SAFE" strategy for trachoma control, while MDA of anthelminthics provides the cornerstone for control of a number of other neglected tropical diseases (NTDs). Simultaneous delivery of two or more of these drugs, renowned as "integrated NTD control," is being promoted to reduce costs and expand intervention coverage. A cost analysis was conducted alongside an MDA campaign in a remote trachoma endemic area, to inform budgeting for NTD control in South Sudan. A first round of antibiotic MDA was conducted in the highly trachoma endemic county of Mayom, Unity state, from June to August 2010. A core team of seven staff delivered the intervention, including recruitment and training of 44 supervisors and 542 community drug distributors. Using an ingredients approach, financial and economic costs were captured from the provider perspective in a detailed costing database. Overall, 123,760 individuals were treated for trachoma, resulting in an estimated treatment coverage of 94%. The economic cost per person treated was USD 1.53, excluding the cost of the antibiotic azithromycin. Ninety four per cent of the delivery costs were recurrent costs, with personnel and travel/transport costs taking up the largest share. In a remote setting and for the initial round, MDA of antibiotics was considerably more expensive than USD 0.5 per person treated, an estimate frequently quoted to advocate for integrated NTD control. Drug delivery costs in South Sudan are unlikely to decrease substantially during subsequent MDA rounds, as the major cost drivers were recurrent costs. MDA campaigns for delivery of one or more drugs in South Sudan should thus be budgeted at around USD 1.5 per person treated, at least until further costing data for delivery of other NTD drugs, singly or in combination, are available.

  11. 78 FR 22451 - Cost Recovery for Permit Processing, Administration, and Enforcement

    Science.gov (United States)

    2013-04-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Office of Surface Mining Reclamation and Enforcement 30 CFR Parts 701, 736, 737, 738, and 750 RIN 1029-AC65 Cost Recovery for Permit Processing, Administration, and Enforcement Correction In proposed...

  12. 78 FR 13056 - Proposed CERCLA Administrative Cost Recovery Settlement; in re: Factory H Superfund Site, Meriden...

    Science.gov (United States)

    2013-02-26

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; in re: Factory H Superfund Site, Meriden...)(1) concerning the Factory H Superfund Site in Meriden, Connecticut (``Site'') with the following... refer to the Factory H Superfund Site, U.S. EPA Docket No. CERCLA-01-2012-0112. FOR FURTHER...

  13. 10 CFR 171.25 - Collection, interest, penalties, and administrative costs.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Collection, interest, penalties, and administrative costs. 171.25 Section 171.25 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ANNUAL FEES FOR REACTOR... other relevant regulations of the United States Government, as appropriate. In the event a...

  14. 78 FR 78589 - Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards

    Science.gov (United States)

    2013-12-26

    ..., non-Federal entities have faced risks of more restrictive oversight and audit findings that stem from.... Targeting Audit Requirements on Risk of Waste, Fraud, and Abuse: The final guidance right-sizes the.... Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards;...

  15. 78 FR 13675 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2013-02-28

    ... accounting practice change, the total potential impact of the change on contracts containing a CAS provision... Regulation; Submission for OMB Review; Cost Accounting Standards Administration AGENCY: Department of Defense...: Under the provisions of the Paperwork Reduction Act, the Regulatory Secretariat will be submitting...

  16. Compact, Low-Cost, Frequency-Locked Semiconductor Laser for Injection Seeding High Power Laser Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This NASA Small Business Innovative Research Phase II project will develop a compact, low-cost, wavelength locked seed laser for injection locking high powered...

  17. Low-Cost and High-Performance Propulsion for Small Satellite Applications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — While small satellites continue to show immense promise for high-capability and low-cost missions, they remain limited by post-deployment propulsion for a variety of...

  18. Very Low-Cost, Rugged, High-Vacuum System for Mass Spectrometers Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA, the DoD, DHS, and commercial industry have a pressing need for miniaturized, rugged, low-cost, high vacuum systems. Recent advances in sensor technology at...

  19. Hummingbird - A Very Low Cost, High Delta V Spacecraft for Solar System Exploration Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Based on Microcosm's development of a high delta-V small Earth observation spacecraft called NanoEye, with a planned recurring cost of $2 million, Microcosm will...

  20. Very Low-Cost, Rugged, High-Vacuum System for Mass Spectrometers Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA, DoD, DHS, and commercial industry have a pressing need for miniaturized, rugged, low-cost high-vacuum systems. Recent advances in sensor technology at NASA and...

  1. Estimating Lifetime Costs of Social Care: A Bayesian Approach Using Linked Administrative Datasets from Three Geographical Areas.

    Science.gov (United States)

    Steventon, Adam; Roberts, Adam

    2015-12-01

    We estimated lifetime costs of publicly funded social care, covering services such as residential and nursing care homes, domiciliary care and meals. Like previous studies, we constructed microsimulation models. However, our transition probabilities were estimated from longitudinal, linked administrative health and social care datasets, rather than from survey data. Administrative data were obtained from three geographical areas of England, and we estimated transition probabilities in each of these sites flexibly using Bayesian methods. This allowed us to quantify regional variation as well as the impact of structural and parameter uncertainty regarding the transition probabilities. Expected lifetime costs at age 65 were £20,200-27,000 for men and £38,700-49,000 for women, depending on which of the three areas was used to calibrate the model. Thus, patterns of social care spending differed markedly between areas, with mean costs varying by almost £10,000 (25%) across the lifetime for people of the same age and gender. Allowing for structural and parameter uncertainty had little impact on expected lifetime costs, but slightly increased the risk of very high costs, which will have implications for insurance products for social care through increasing requirements for capital reserves.

  2. Costs Associated with Intravenous Cancer Therapy Administration in Patients with Metastatic Soft Tissue Sarcoma in a US Population

    Directory of Open Access Journals (Sweden)

    Mei Sheng Duh

    2013-01-01

    Full Text Available Background. The most common chemotherapies in metastatic soft tissue sarcoma (mSTS require intravenous (IV administration. This often requires patients to make multiple outpatient visits per chemotherapy cycle, possibly impeding patients’ daily activities and increasing caregiver burden and medical costs. This study investigated costs associated with IV cancer therapy administration in mSTS from the payer perspective of the health care system. Patients and Methods. From the Experian Healthcare database, 1,228 mSTS patients were selected. Data were analyzed on outpatient visits during 2005–2012 involving IV cancer therapy administration. Costs were estimated on a per patient per visit (PPPV and per patient per month (PPPM basis. Results. The mean (median cost of IV therapy was $2,427 ($1,532 PPPV and $5,468 ($4,310 PPPM, of which approximately 60% was IV drug costs. IV administration costs averaged $399 PPPV and $900 PPPM, representing 16.5% of total visit costs. Anthracycline and alkylating-agents-based therapies had the highest PPPV and PPPM IV administration costs, respectively (mean $479 and $1,336, resp.. Patients with managed care insurance had the highest IV administration costs (mean $504 PPPV; $1,120 PPPM. Conclusions. IV administration costs constitute a considerable proportion of the total costs of receiving an IV cancer therapy to treat mSTS.

  3. Distribution and cost of wheelchairs and scooters provided by Veterans Health Administration.

    Science.gov (United States)

    Hubbard, Sandra L; Fitzgerald, Shirley G; Vogel, Bruce; Reker, Dean M; Cooper, Rory A; Boninger, Michael L

    2007-01-01

    During fiscal years 2000 and 2001, the Veterans Health Administration provided veterans with more than 131,000 wheelchairs and scooters at a cost of $109 million. This national study is the first to investigate Veterans Health Administration costs in providing wheelchairs and scooters and to compare regional prescription patterns. With a retrospective design, we used descriptive methods to analyze fiscal years 2000 and 2001 National Prosthetics Patient Database data (cleaned data set of 113,724 records). Wheelchairs were categorized by function, weight, and adjustability options for meeting individual needs (e.g., axle position, camber, position of wheels, tilt, and recline options). Results displayed a cost distribution that was negatively skewed by low-cost accessories coded as wheelchairs. Of the standard manual wheelchairs, 3.5% could be considered beyond the customary cost. Regionally, 71% to 86% of all wheelchairs provided were manual wheelchairs, 5% to 11% were power wheelchairs, and 5% to 20% were scooters. The considerable variation found in the types of wheelchairs and scooters provided across Veterans Integrated Service Networks may indicate a need for evidence-based prescription guidelines and clinician training in wheeled-mobility technologies.

  4. Low cost, high performance far infrared microbolometer

    Science.gov (United States)

    Roer, Audun; Lapadatu, Adriana; Elfving, Anders; Kittilsland, Gjermund; Hohler, Erling

    2010-04-01

    Far infrared (FIR) is becoming more widely accepted within the automotive industry as a powerful sensor to detect Vulnerable Road Users like pedestrians and bicyclist as well as animals. The main focus of FIR system development lies in reducing the cost of their components, and this will involve optimizing all aspects of the system. Decreased pixel size, improved 3D process integration technologies and improved manufacturing yields will produce the necessary cost reduction on the sensor to enable high market penetration. The improved 3D process integration allows a higher fill factor and improved transmission/absorption properties. Together with the high Thermal Coefficient of Resistance (TCR) and low 1/f noise properties provided by monocrystalline silicon germanium SiGe thermistor material, they lead to bolometer performances beyond those of existing devices. The thermistor material is deposited and optimized on an IR wafer separated from the read-out integrated circuit (ROIC) wafer. The IR wafer is transferred to the ROIC using CMOS compatible processes and materials, utilizing a low temperature wafer bonding process. Long term vacuum sealing obtained by wafer scale packaging enables further cost reductions and improved quality. The approach allows independent optimization of ROIC and thermistor material processing and is compatible with existing MEMS-foundries, allowing fast time to market.

  5. Costs of Integrated Mass Drug Administration for Neglected Tropical Diseases in Haiti

    Science.gov (United States)

    Goldman, Ann S.; Brady, Molly A.; Direny, Abdel; Desir, Luccene; Oscard, Roland; Vely, Jean-Francois; Linehan, Mary; Baker, Margaret

    2011-01-01

    We conducted a cost analysis of Haiti's Ministry of Public Health and Population neglected tropical disease program, Projet des Maladies Tropicales Negligées and collected data for 9 of 55 communes participating in the May 2008–April 2009 mass drug administration (MDA). The Projet des Maladies Tropicales Negligées Program partnered with IMA World Health and Hôpital Ste. Croix to implement MDA for treatment of lymphatic filariasis and soil-transmitted helminthiasis by using once a year treatment with albendazole and diethylcarbamazine in a population of approximately 8 million persons. Methods included analyzing partner financial records and conducting retrospective surveys of personnel. In the nine communes, 633,261 persons were treated at a cost of U.S. $0.64 per person, which included the cost of donated drugs, and at a cost of U.S. $0.42 per person treated, when excluding donated drug costs. The MDA for lymphatic filariasis in Haiti began in 2000, with the treatment of 105,750 persons at a cost per person of U.S. $2.23. The decrease in cost per person treated is the result of cumulative implementation experience and economies of scale. PMID:22049035

  6. Effective Instructional Management: Perceptions and Recommendations from High School Administrators

    Science.gov (United States)

    Knechtel, Troy

    2010-01-01

    The two overarching research questions of this study are: What are the perceptions of high school administrators regarding the effectiveness of their current approach to instructional management? What recommendations do high school administrators have for effective strategies for instructional management? To answer these questions, a qualitative…

  7. Effective Instructional Management: Perceptions and Recommendations from High School Administrators

    Science.gov (United States)

    Knechtel, Troy

    2010-01-01

    The two overarching research questions of this study are: What are the perceptions of high school administrators regarding the effectiveness of their current approach to instructional management? What recommendations do high school administrators have for effective strategies for instructional management? To answer these questions, a qualitative…

  8. 20 CFR 669.555 - Do the WIA administrative cost limits for States and local areas apply to NFJP grants?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Do the WIA administrative cost limits for... WORKFORCE INVESTMENT ACT Performance Accountability, Planning and Waiver Provision § 669.555 Do the WIA administrative cost limits for States and local areas apply to NFJP grants? No, under 20 CFR 667.210(b),...

  9. 20 CFR 667.210 - What administrative cost limits apply to Workforce Investment Act title I grants?

    Science.gov (United States)

    2010-04-01

    ... Workforce Investment Act title I grants? 667.210 Section 667.210 Employees' Benefits EMPLOYMENT AND TRAINING... reserved for local administrative costs needs to be allocated back to the individual funding streams. (b) Limits on administrative costs for programs operated under subtitle D of title I will be identified...

  10. Risk-Adjusted Impact of Administrative Costs on the Distribution of Terminal Wealth for Long-Term Investment

    Directory of Open Access Journals (Sweden)

    Montserrat Guillén

    2014-01-01

    Full Text Available The impact of administrative costs on the distribution of terminal wealth is approximated using a simple formula applicable to many investment situations. We show that the reduction in median returns attributable to administrative fees is usually at least twice the amount of the administrative costs charged for most investment funds, when considering a risk-adjustment correction over a reasonably long-term time horizon. The example we present covers a number of standard cases and can be applied to passive investments, mutual funds, and hedge funds. Our results show investors the potential losses they face in performance due to administrative costs.

  11. Risk-adjusted impact of administrative costs on the distribution of terminal wealth for long-term investment.

    Science.gov (United States)

    Guillén, Montserrat; Jarner, Søren Fiig; Nielsen, Jens Perch; Pérez-Marín, Ana M

    2014-01-01

    The impact of administrative costs on the distribution of terminal wealth is approximated using a simple formula applicable to many investment situations. We show that the reduction in median returns attributable to administrative fees is usually at least twice the amount of the administrative costs charged for most investment funds, when considering a risk-adjustment correction over a reasonably long-term time horizon. The example we present covers a number of standard cases and can be applied to passive investments, mutual funds, and hedge funds. Our results show investors the potential losses they face in performance due to administrative costs.

  12. Ultra High Brightness/Low Cost Fiber Coupled Packaging Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The focus of the proposed effort is maximizing the brightness of fiber coupled laser diode pump sources at a minimum cost. The specific innovation proposed is to...

  13. A Low-Cost, High-Precision Navigator Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Toyon Research Corporation proposes to develop and demonstrate a prototype low-cost precision navigation system using commercial-grade gyroscopes and accelerometers....

  14. A Low Cost High Specific Stiffness Mirror Substrate Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The primary purpose of this proposal is to develop and demonstrate a new technology for manufacturing an ultra-low-cost precision optical telescope mirror which can...

  15. The impact of scale, complexity, and service quality on the administrative costs of pension funds: A cross-country comparison

    NARCIS (Netherlands)

    Bikker, J.A.; Steenbeek, O.W.; Torracchi, F.

    2010-01-01

    Administrative costs per participant appear to vary widely across pension funds in different countries. These costs are important because they reduce the rate of return on the investments of pension funds, and consequently raise the cost of retirement security. Using unique data on 90 pension funds

  16. Cost of readmission: can the Veterans Health Administration (VHA) experience inform national payment policy?

    Science.gov (United States)

    Hockenberry, Jason M; Burgess, James F; Glasgow, Justin; Vaughan-Sarrazin, Mary; Kaboli, Peter J

    2013-01-01

    Scrutiny of hospital readmissions has led to the development and implementation of policies targeted at reducing readmission rates. To assess whether historic hospital readmission rates predict risk-adjusted patient readmission and to measure the costs of readmission, thus informing reimbursement policies under consideration by non-Veterans Health Administration payers. Multivariable hospital-fixed effects regression analyses of patients admitted to 129 Veterans Health Administration hospitals between 2005 and 2009 for 3 common conditions, acute myocardial infarction (AMI), community-acquired pneumonia (CAP), and congestive heart failure (CHF). We examined whether previous hospital readmission rates predicted risk-adjusted readmission or 30-day episode cost of care for subsequent patients. We then examined the 30-day inpatient hospitalization episode cost differences between those who had a readmission in the episode and those who did not. Hospital readmission rates in the previous quarter are not predictive of individual patient risk-adjusted readmission or of patients' inpatient hospitalization episode cost in the subsequent quarter. Relative to those who were not readmitted within 30 days of index visit discharge, readmitted patients had 30-day episode costs that were 53.3% (P<0.001), 82.8% (P<0.001), and 79.8% (P<0.001) higher for AMI, CAP, and CHF hospitalization episodes, respectively. Previous hospital readmission rates are poor predictors of readmission for future individual patients, therefore, policies using these measures to guide subsequent reimbursement are problematic for hospitals that are financially constrained. Our findings indicate current diagnosis related group payments would need to be raised by 10.0% for AMI, 11.5% for CAP, and 16.6% for CHF if these are to become 30-day bundled payments.

  17. Low cost high performance uncertainty quantification

    KAUST Repository

    Bekas, C.

    2009-01-01

    Uncertainty quantification in risk analysis has become a key application. In this context, computing the diagonal of inverse covariance matrices is of paramount importance. Standard techniques, that employ matrix factorizations, incur a cubic cost which quickly becomes intractable with the current explosion of data sizes. In this work we reduce this complexity to quadratic with the synergy of two algorithms that gracefully complement each other and lead to a radically different approach. First, we turned to stochastic estimation of the diagonal. This allowed us to cast the problem as a linear system with a relatively small number of multiple right hand sides. Second, for this linear system we developed a novel, mixed precision, iterative refinement scheme, which uses iterative solvers instead of matrix factorizations. We demonstrate that the new framework not only achieves the much needed quadratic cost but in addition offers excellent opportunities for scaling at massively parallel environments. We based our implementation on BLAS 3 kernels that ensure very high processor performance. We achieved a peak performance of 730 TFlops on 72 BG/P racks, with a sustained performance 73% of theoretical peak. We stress that the techniques presented in this work are quite general and applicable to several other important applications. Copyright © 2009 ACM.

  18. Assessing the cost-effectiveness of COX-2 specific inhibitors for arthritis in the Veterans Health Administration.

    Science.gov (United States)

    Schaefer, Monica; DeLattre, Melissa; Gao, Xin; Stephens, Jennifer; Botteman, Marc; Morreale, Anthony

    2005-01-01

    This study was designed to assess the cost-effectiveness of cyclooxygenase-2 specific (COX-2) inhibitors (rofecoxib and celecoxib) over nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) in high-risk arthritis patients from the perspective of the Veterans Health Administration (VA). This literature-based economic analysis (with data summarized from MEDLINE-indexed and other published sources, FDA reports, and data on file at VA San Diego Healthcare System) compared rofecoxib and celecoxib to NSAIDS in two arthritis patient populations considered at higher risk of developing clinically significant upper gastrointestinal events (CSUGIEs): (1) patients of any age with previous medical history of perforation/ulcer/bleed (PUB); and (2) patients 65 years and older (regardless of history of PUB). Two outcome measures were reported: (1) incremental cost per CSUGIE averted over 1 year; and (2) incremental cost per quality-adjusted life-year (QALY) gained, considering both the mortality and morbidity associated with gastrointestinal (including CSUGIEs) and cardiovascular-related adverse events. When possible, costs were modeled to reflect the VA perspective. Sensitivity analyses were conducted to test the robustness of the analysis. Compared to NSAIDS, rofecoxib and celecoxib increased costs but reduced the incidence of CSUGIE. Cost per CSUGIE avoided were $7476 and $16,379 (in patients with a PUB history) and $14,294 and $18,376 (in patients aged > or = 65 years) for celecoxib and rofecoxib, respectively. In both populations, celecoxib was associated with a cost per QALY less than $50,000. In contrast, rofecoxib was found to cost more and result in a net QALY loss, due in particular to the increase in the risk of cardiovascular complications, and was therefore considered cost-ineffective. Results were most dependent on assumptions about the incidence of cardiovascular events and CSUGIE and the COX-2 inhibitors' acquisition price. This analysis suggests that COX-2

  19. How to avoid the high costs of physician turnover.

    Science.gov (United States)

    Berger, J E; Boyle, R L

    1992-01-01

    Physician recruitment is a complex, time consuming and competitive activity that is costly in terms of incurred expenses, administrative and physician time and lost revenue. Judith Berger and Robert Boyle, FACMGA, describe how to develop a well-designed retention and recruitment plan to avoid such costs.

  20. How to think clearly about Medicare administrative costs: data sources and measurement.

    Science.gov (United States)

    Sullivan, Kip

    2013-06-01

    The Centers for Medicare and Medicaid Services (CMS) annually publishes two measures of Medicare's administrative expenditures. One of these appears in the reports of the Medicare Boards of Trustees and the other in the National Health Expenditure Accounts (NHEA). The latest trustees' report indicates Medicare's administrative expenditures are 1 percent of total Medicare spending, while the latest NHEA indicates the figure is 6 percent. The debate about Medicare's administrative expenditures, which emerged several years ago, reflects widespread confusion about these data. Critics of Medicare argue that the official reports on Medicare's overhead ignore or hide numerous types of administrative spending, such as the cost of collecting taxes and Part B premiums. Defenders of Medicare claim the official statistics are accurate. But participants on both sides of this debate fail to cite the official documents and do not analyze CMS's methodology. This article examines the controversy over the methodology CMS uses to calculate the trustees' and NHEA's measures and the sources of confusion and ignorance about them. It concludes with a discussion of how the two measures should be used.

  1. Modeling the impact and costs of semiannual mass drug administration for accelerated elimination of lymphatic filariasis.

    Directory of Open Access Journals (Sweden)

    Wilma A Stolk

    Full Text Available The Global Program to Eliminate Lymphatic Filariasis (LF has a target date of 2020. This program is progressing well in many countries. However, progress has been slow in some countries, and others have not yet started their mass drug administration (MDA programs. Acceleration is needed. We studied how increasing MDA frequency from once to twice per year would affect program duration and costs by using computer simulation modeling and cost projections. We used the LYMFASIM simulation model to estimate how many annual or semiannual MDA rounds would be required to eliminate LF for Indian and West African scenarios with varied pre-control endemicity and coverage levels. Results were used to estimate total program costs assuming a target population of 100,000 eligibles, a 3% discount rate, and not counting the costs of donated drugs. A sensitivity analysis was done to investigate the robustness of these results with varied assumptions for key parameters. Model predictions suggested that semiannual MDA will require the same number of MDA rounds to achieve LF elimination as annual MDA in most scenarios. Thus semiannual MDA programs should achieve this goal in half of the time required for annual programs. Due to efficiency gains, total program costs for semiannual MDA programs are projected to be lower than those for annual MDA programs in most scenarios. A sensitivity analysis showed that this conclusion is robust. Semiannual MDA is likely to shorten the time and lower the cost required for LF elimination in countries where it can be implemented. This strategy may improve prospects for global elimination of LF by the target year 2020.

  2. Individual social security accounts: issues in assessing administrative feasibility and costs.

    Science.gov (United States)

    Olsen, K A; Salisbury, D L

    1998-11-01

    Whether to add individual accounts (IAs) to the Social Security system is a highly political issue. But almost lost in the debate so far have been any practical considerations about how to administer such accounts. Any discussion of whether to create individual accounts must also address the basic but critical questions of how they would work: Who would run them? What would they cost? Logistically, are they even possible? This EBRI Issue Brief provides an overview of the most salient administrative issues facing the current Social Security reform debate--issues that challenge proponents to carefully think through how their proposals could be implemented so as to achieve their policy goals. The options and difficulties in administering IAs raise concerns that cut across ideology. The object of this report is neither to dissuade the advocates nor support the critics of individual accounts. Rather, it is to bring practical considerations to a political debate that has largely ignored the pragmatic challenges of whether IAs would be too complex for participants to understand or too difficult for record keepers to administer. The major findings in this analysis include: Adding individual accounts to Social Security could be the largest undertaking in the history of the U.S. financial market, and no system to date has the capacity to administer such a system. The number of workers currently covered by Social Security--the largest single entitlement program in the nation--is at least four times higher than the combined number of all tax-favored employment-based retirement accounts in the United States, which are administered by hundreds of entities. Direct comparisons between employment-based retirement savings plans and Social Security reform are tenuous at best. Social Security covers workers and businesses that are disproportionately excluded from employment-based plans. Because of these differences, a system of individual Social Security accounts would be more

  3. Administration

    DEFF Research Database (Denmark)

    Bogen handler om den praksis, vi kalder administration. Vi er i den offentlige sektor i Danmark hos kontorfolkene med deres sagsmapper, computere, telefoner,, lovsamlinger,, retningslinier og regneark. I bogen udfoldes en mangfoldighed af konkrete historier om det administrative arbejde fra...... forskellige områder i den offentlige sektor. Hensigten er at forstå den praksis og faglighed der knytter sig til det administrative arbejde...

  4. Good agreement between questionnaire and administrative databases for health care use and costs in patients with osteoarthritis

    Directory of Open Access Journals (Sweden)

    Robertson M Clare

    2011-04-01

    Full Text Available Abstract Background Estimating costs is essential to the economic analysis of health care programs. Health care costs are often captured from administrative databases or by patient report. Administrative records only provide a partial representation of health care costs and have additional limitations. Patient-completed questionnaires may allow a broader representation of health care costs; however the validity and feasibility of such methods have not been firmly established. This study was conducted to assess the validity and feasibility of using a patient-completed questionnaire to capture health care use and costs for patients with osteoarthritis, and to compare the research costs of the data-capture methods. Methods We designed a patient questionnaire and applied it in a clinical trial. We captured equivalent data from four administrative databases. We evaluated aspects of the questionnaire's validity using sensitivity and specificity, Lin's concordance correlation coefficient (ρc, and Bland-Altman comparisons. Results The questionnaire's response rate was 89%. Acceptable sensitivity and specificity levels were found for all types of health care use. The numbers of visits and the majority of medications reported by patients were in agreement with the database-derived estimates (ρc > 0.40. Total cost estimates from the questionnaire agreed with those from the databases. Patient-reported co-payments agreed with administrative records with respect to GP office transactions, but not pharmaceutical co-payments. Research costs for the questionnaire-based method were less than one-third of the costs for the databases method. Conclusion A patient-completed questionnaire is feasible for capturing health care use and costs for patients with osteoarthritis, and data collected using it mostly agree with administrative databases. Caution should be exercised when applying unit costs and collecting co-payment data.

  5. Low Cost, High Efficiency, High Pressure Hydrogen Storage

    Energy Technology Data Exchange (ETDEWEB)

    Mark Leavitt

    2010-03-31

    A technical and design evaluation was carried out to meet DOE hydrogen fuel targets for 2010. These targets consisted of a system gravimetric capacity of 2.0 kWh/kg, a system volumetric capacity of 1.5 kWh/L and a system cost of $4/kWh. In compressed hydrogen storage systems, the vast majority of the weight and volume is associated with the hydrogen storage tank. In order to meet gravimetric targets for compressed hydrogen tanks, 10,000 psi carbon resin composites were used to provide the high strength required as well as low weight. For the 10,000 psi tanks, carbon fiber is the largest portion of their cost. Quantum Technologies is a tier one hydrogen system supplier for automotive companies around the world. Over the course of the program Quantum focused on development of technology to allow the compressed hydrogen storage tank to meet DOE goals. At the start of the program in 2004 Quantum was supplying systems with a specific energy of 1.1-1.6 kWh/kg, a volumetric capacity of 1.3 kWh/L and a cost of $73/kWh. Based on the inequities between DOE targets and Quantum’s then current capabilities, focus was placed first on cost reduction and second on weight reduction. Both of these were to be accomplished without reduction of the fuel system’s performance or reliability. Three distinct areas were investigated; optimization of composite structures, development of “smart tanks” that could monitor health of tank thus allowing for lower design safety factor, and the development of “Cool Fuel” technology to allow higher density gas to be stored, thus allowing smaller/lower pressure tanks that would hold the required fuel supply. The second phase of the project deals with three additional distinct tasks focusing on composite structure optimization, liner optimization, and metal.

  6. Low cost, high tech seed cleaning

    Science.gov (United States)

    Robert P. Karrfalt

    2013-01-01

    Clean seeds are a great asset in native plant restoration. However, seed cleaning equipment is often too costly for many small operations. This paper introduces how several tools and materials intended for other purposes can be used directly or made into simple machines to clean seeds.

  7. The High Cost of Saving Energy Dollars.

    Science.gov (United States)

    Rose, Patricia

    1985-01-01

    In alternative financing a private company provides the capital and expertise for improving school energy efficiency. Savings are split between the school system and the company. Options for municipal leasing, cost sharing, and shared savings are explained along with financial, procedural, and legal considerations. (MLF)

  8. The cost of first-ever stroke in Valle d’Aosta, Italy: linking clinical registries and administrative data

    Directory of Open Access Journals (Sweden)

    Bottacchi Edo

    2012-10-01

    Full Text Available Abstract Background Stroke is one of the most relevant reasons of death and disability worldwide. Many cost of illness studies have been performed to evaluate direct and indirect costs of ischaemic stroke, especially within the first year after the acute episode, using different methodologies. Methods We conducted a longitudinal, retrospective, bottom-up cost of illness study, to evaluate clinical and economic outcomes of a cohort of patients affected by a first cerebrovascular event, including subjects with ischaemic, haemorrhagic or transient episodes. The analysis intended to detect direct costs, within 1, 2 and 3 years from the index event. Clinical patient data collected in regional disease registry were integrated and linked to regional administrative databases to perform the analysis. Results The analysis of costs within the first year from the index event included 800 patients. The majority of patients (71.5% were affected by ischaemic stroke. Overall, per patient costs were €7,079. Overall costs significantly differ according to the type of stroke, with costs for haemorrhagic stroke and ischaemic stroke amounting to €9,044 and €7,289. Hospital costs, including inpatient rehabilitation, were driver of expenditure, accounting for 89.5% of total costs. The multiple regression model showed that sex, level of physical disability and level of neurological deficit predict direct healthcare costs within 1 year. The analysis at 2 and 3 years (per patient costs: €7,901 and €8,874, respectively showed that majority of costs are concentrated in the first months after the acute event. Conclusions This cost analysis highlights the importance to set up significant prevention programs to reduce the economic burden of stroke, which is mostly attributable to hospital and inpatient rehabilitation costs immediately after the acute episode. Although some limitation typical of retrospective analyses the approach of linking clinical and

  9. Case mix, quality and high-cost kidney transplant patients.

    Science.gov (United States)

    Englesbe, M J; Dimick, J B; Fan, Z; Baser, O; Birkmeyer, J D

    2009-05-01

    A better understanding of high-cost kidney transplant patients would be useful for informing value-based purchasing strategies by payers. This retrospective cohort study was based on the Medicare Provider Analysis and Review (MEDPAR) files from 2003 to 2006. The focus of this analysis was high-cost kidney transplant patients (patients that qualified for Medicare outlier payments and 30-day readmission payments). Using regression techniques, we explored relationships between high-cost kidney transplant patients, center-specific case mix, and center quality. Among 43 393 kidney transplants in Medicare recipients, 35.2% were categorized as high-cost patients. These payments represented 20% of total Medicare payments for kidney transplantation and exceeded $200 million over the study period. Case mix was associated with these payments and was an important factor underlying variation in hospital payments high-cost patients. Hospital quality was also a strong determinant of future Medicare payments for high-cost patients. Compared to high-quality centers, low-quality centers cost Medicare an additional $1185 per kidney transplant. Payments for high-cost patients represent a significant proportion of the total costs of kidney transplant surgical care. Quality improvement may be an important strategy for reducing the costs of kidney transplantation.

  10. Case Mix, Quality and High-Cost Kidney Transplant Patients

    OpenAIRE

    Englesbe, M. J.; Dimick, J. B.; Fan, Z; Baser, O.; Birkmeyer, J. D.

    2009-01-01

    A better understanding of high-cost kidney transplant patients would be useful for informing value-based purchasing strategies by payers. This retrospective cohort study was based on the Medicare Provider Analysis and Review (MEDPAR) files from 2003 to 2006. The focus of this analysis was high-cost kidney transplant patients (patients that qualified for Medicare outlier payments and 30-day readmission payments). Using regression techniques, we explored relationships between high-cost kidney t...

  11. 有效降低行政成本的路径探讨%On the Approach to Reducing Effectively the Cost of Administration

    Institute of Scientific and Technical Information of China (English)

    林淑珍

    2012-01-01

    A big problem that faces all countries in the reform of the administrative system is how to reduce the cost of administration and improve its effectiveness. The cost of administration in China has always remained high and many problems are waiting to be solved urgently. Therefore, based on the analysis of the status quo of China's cost of administration and the formative causes, this paper proposes to be aware of cost and to build an effective and inexpensive government.%各国行政管理体制改革过程中面临的一个重要难题:即如何降低行政成本,提高行政效率。我国行政成本一直居高不下,存在诸多问题亟待解决。为此基于对我国行政成本的运行现状、形成原因的分析,继而提出树立成本意识,建立高效、廉价政府。

  12. High efficiency low cost GaAs/Ge cell technology

    Science.gov (United States)

    Ho, Frank

    1990-01-01

    Viewgraphs on high efficiency low cost GaAs/Ge cell technology are presented. Topics covered include: high efficiency, low cost GaAs/Ge solar cells; advantages of Ge; comparison of typical production cells for space applications; panel level comparisons; and solar cell technology trends.

  13. High-Efficiency Solar Cells on Low-Cost Substrates

    Science.gov (United States)

    Daiello, R. V.; Robinson, P. H.

    1982-01-01

    High-efficiency solar cells made in thin epitaxial films grown on low-cost commercial silicon substrates. Cost of cells is much less than if high-quality single-crystal silicon were used for substrates and performance of cells is almost as good.

  14. High Channel Count, Low Cost, Multiplexed FBG Sensor Systems

    Institute of Scientific and Technical Information of China (English)

    J. J. Pan; FengQing Zhou; Kejian Guan; Joy Jiang; Liang Dong; Albert Li; Xiangdong Qiu; Jonathan Zhang

    2003-01-01

    With rich products development experience in WDM telecommunication networks, we introduce a few of high channel count, multiplexed FBG fiber optic sensor systems featured in reliable high performance and low cost.

  15. Administrative databases as a tool for identifying healthcare demand and costs in an over-one million population

    Directory of Open Access Journals (Sweden)

    Fabiana Madotto

    2013-06-01

    Full Text Available Background: the aim of this study was to assess healthcare demand of specific groups of population and their costs borne by Italian Health System, using healthcare administrative databases.Methods: demographic, clinical and economic data were obtained from datasets available at the Regional Health System, combined into a data warehouse (DENALI, using a probabilistic record linkage to optimize the data matching process. The study population consisted of more than 1 million people registered in 2005 at one Local Healthcare Unit of Lombardy. Eight different segments were identified. Costs occurring in 2005 for hospital admissions, drug prescriptions, outpatient medical specialist visits were quantified in each segment.Results: healthy people accounted for 53% of the population and cost € 180 per-capita. Subjects with only one chronic disease made up 16% of the population and cost € 916 per-capita, those affected by several chronic diseases accounted for 13% and cost € 3 457 per-capita. Hospitalizations were the cost driver in five segments, ranging from 42% to 89% of total expenditures. Outpatient visits were the cost driver among healthy subjects (54% and those with a possible chronic disease (42%, while drug costs ranged between 4% (“acute event” and 32% (“one chronic disease”. Overall, healthcare cost was € 809 per-capita.Conclusions: healthcare costs were mainly determined by people affected by chronic conditions, even if “healthy people” ranked third for total expenditure. These costs need an appropriate identification of healthcare demand, that could be efficiently monitored through the use of administrative databases.

  16. Capital cost: low and high sulfur coal plants; 800 MWe

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    This Commercial Electric Power Cost Study for 800-MWe (Nominal) low- and high-sulfur coal plants consists of three volumes. (This is the fourth subject in a series of eight performed in the Commercial Electric Power Cost Studies by the US NRC). The low-sulfur coal plant is described in Volumes I and II, while Volume III (this volume) describes the high sulfur coal plant. The design basis, drawings, and summary cost estimate for a 794-MWe high-sulfur coal plant are presented in this volume. This information was developed by redesigning the low-sulfur sub-bituminous coal plant for burning high-sulfur bituminous coal. The reference design includes a lime flue-gas-desulfurization system. These coal plants utilize a mechanical draft (wet) cooling tower system for condenser heat removal. Costs of alternate cooling systems are provided in Report No. 7 in this series of studies of costs of commercial electrical power plants.

  17. 31 CFR 5.5 - How will Treasury entities add interest, penalty charges, and administrative costs to a Treasury...

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false How will Treasury entities add interest, penalty charges, and administrative costs to a Treasury debt? 5.5 Section 5.5 Money and Finance: Treasury Office of the Secretary of the Treasury TREASURY DEBT COLLECTION Procedures To Collect...

  18. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect...

  19. Parents and the High Cost of Child Care: 2014 Report

    Science.gov (United States)

    Wood, Stephen; Fraga, Lynette; McCready, Michelle

    2014-01-01

    Eleven million children younger than age five are in some form of child care in the United States. The "Parents and the High Cost of Child Care: 2014 Report" summarizes the cost of child care across the country, examines the importance of child care as a workforce support and as an early learning program, and explores the effect of high…

  20. Parents and the High Cost of Child Care: 2015 Report

    Science.gov (United States)

    Fraga, Lynette; Dobbins, Dionne; McCready, Michelle

    2015-01-01

    Eleven million children younger than age five are in some form of child care in the United States. The "Parents and the High Cost of Child Care: 2015 Report" summarizes the cost of child care across the country, examines the importance of child care as a workforce support and as an early learning program, and explores the effect of high…

  1. A Comparative Analysis of the Costs of Administration of an OSCE.

    Science.gov (United States)

    Cusimano, Michael D.; And Others

    1994-01-01

    A study compared the costs of a six-station structured oral examination and an objective structured clinical examination (OSCE) for a surgery clerkship, assessing both faculty and materials costs. The OSCE was found to be more time consuming and expensive. Cost-cutting measures and guidelines to assist medical schools in selecting test type are…

  2. 20 CFR 645.235 - What types of activities are subject to the administrative cost limit on Welfare-to-Work grants?

    Science.gov (United States)

    2010-04-01

    ...) Although administrative in nature, costs of information technology—computer hardware and software—needed... WtW including: (i) Accounting, budgeting, financial and cash management functions; (ii) Procurement... administrative functions (for example, personnel, procurement, purchasing, property management, accounting...

  3. Subcutaneous vs intravenous administration of immunoglobulin in chronic inflammatory demyelinating polyneuropathy: an Italian cost-minimization analysis.

    Science.gov (United States)

    Lazzaro, Carlo; Lopiano, Leonardo; Cocito, Dario

    2014-07-01

    Prior researches have suggested that home-based subcutaneous immunoglobulin (SCIG) is equally effective and can be less expensive than hospital-based intravenous immunoglobulin (IVIG) in treating chronic inflammatory demyelinating polyneuropathy (CIDP) patients. This economic evaluation aims at comparing costs of SCIG vs IVIG for CIDP patients in Italy. A 1-year model-based cost-minimization analysis basically populated via neurologists' opinion was undertaken from a societal perspective. Health care resources included immunoglobulin; drugs for premedication and complications (rash, headache, and hypertension) management; time of various health care professionals; pump for SCIG self-administration; infusion disposables. Non-health care resources encompassed transport and parking; losses of working and leisure time for patients and caregivers. Unit or yearly costs for resources valuation were mainly obtained from published sources. Costs were expressed in Euro () 2013. An extensive one-way sensitivity analysis (OWSA) and a scenario SA tested the robustness of the base case findings. Overall costs per patient amount to 49,534.75 (SCIG) and 50,895.73 (IVIG); saving in favour of SCIG reaches 1360.98. For both SCIG and IVIG, the cost driver was immunoglobulin (94.06 vs 86.06 % of the overall costs, respectively). Sensitivity analyses confirmed the consistency of the baseline results. SCIG may be a cost-saving therapy for Italian CIDP patients.

  4. Estimating the cost of diabetes mellitus-related events from inpatient admissions in Sweden using administrative hospitalization data.

    Science.gov (United States)

    Gerdtham, Ulf-G; Clarke, Philip; Hayes, Alison; Gudbjornsdottir, Soffia

    2009-01-01

    To estimate short- and long-term costs of inpatient hospitalization in Sweden for major diabetes mellitus-related events. Costs were estimated using administrative hospital data from the Swedish National Board of Health and Welfare, which is linked to the Swedish National Diabetes Register. Data were available for 179 749 patients with diabetes in Sweden from 1998 to 2003 (mean and median duration of 6 years' follow-up). Costing of inpatient admissions was based on Nordic diagnosis-related groups (NordDRG). Multiple regression analysis (linear and generalizing estimating equation models) was used to estimate inpatient care costs controlling for age, sex and co-morbidities. The data on hospitalizations were converted to costs (euro) using 2003 exchange rates. The average annual costs (linear model) associated with inpatient admissions for a 60-year-old male in the year the first event first occurred were as follows: euro6488 (95% CI 5034, 8354) for diabetic coma; euro6850 (95% CI 6514, 7204) for heart failure; euro7853 (95% CI 7559, 8144) for non-fatal stroke; euro8121 (95% CI 7104, 9128) for peripheral circulatory complications; euro8736 (95% CI 8474, 9001) for non-fatal myocardial infarction (MI); euro10 360 (95% CI 10 085, 10 643) for ischaemic heart disease; euro11 411 (95% CI 10 298, 12 654) for renal failure; and euro14 949 (95% CI 13 849, 16 551) for amputation. On average, the costs were higher when co-morbidity was accounted for (e.g. MI with co-morbidity was twice as costly as MI alone). Average hospital inpatient costs associated with common diabetes-related events can be estimated using panel data regression methods. These could assist in modelling of long-term costs of diabetes and in evaluating the cost effectiveness of improving care.

  5. 政府行政成本的法经济学思考%Thinking of Government Administrative Cost from the Perspective of Law and Economics

    Institute of Scientific and Technical Information of China (English)

    沙季超

    2015-01-01

    Government administrative cost is the administrative input or consumed resources when the government provides certain pub-lic services.For a long time,in our government administrative activities,the concept of administrative cost is not truly set up.The su-pervision mechanism is not perfect,causing problems like high administrative costs,administrative personnel overstaffed,and unsicen-tific administrative decision.Therefore,we must start from updating the concept of administrative cost of the government,increase the intensity of the transformation of government functions,improve scientific and democratic decision -making system,strengthen supervi-sion and standardize the financial budget and operation system,and control "three expenditures"budget,so as to ultimately achieve the goal of constructing a competent,honest and efficient government in China.%政府行政成本是政府向社会提供一定的公共服务所需要的行政投入或耗费的资源。长期以来,在我国各级政府的行政活动中,实际上并没有真正树立行政成本的概念,监督机制也不健全,造成了诸如行政成本居高不下、人员臃肿、决策不科学等问题。为此,我们必须从更新政府的行政成本的概念着手,加大力度转变政府职能,健全科学民主的决策体制,加强监督,规范财政预算运行体制,控制“三公”经费的开支,最终实现我国建设精干效能、清正廉洁的高绩效政府的改革目标。

  6. Analyses of Ways to Reduce the Administrative Cost%降低我国政府行政成本的路径研究

    Institute of Scientific and Technical Information of China (English)

    薛晓东; 杨翠碧

    2013-01-01

      我国政府行政成本过高,其原因在于公务人员成本意识观念淡薄、政府采购体系不完善、政府规模成本过高、政府职能过于宽泛、政府成本监督机制不完善。降低政府行政成本的路径是强化行政成本意识,优化公务人员素质;改进与完善我国政府的采购体系;加强政府自身改革建设;完善和优化我国财政支出结构;强化监督管理,建立行政成本监督机制;加强政府和第三部门的合作力度;推行政府电子政务建设。%  The reason why our government administrative cost is very high is that government’s cost awareness is indifferent, governmental procurement’s system is unreasonable, the governmental large-scale cost is high, governmental functions’ range is too broad, and the governmental cost monitoring mechanism is not perfect. This paper proposes the following ways to reduce administrative cost: strengthening administrative cost’s consciousness, improving the governmental procurement’s system, consolidating our governmental reform construction, intensifying the management by supervision, strengthening the cooperation, and carrying out E-government constructions.

  7. A Phenomenological Cost Model for High Energy Particle Accelerators

    CERN Document Server

    Shiltsev, Vladimir

    2014-01-01

    Accelerator-based high-energy physics have been in the forefront of scientific discoveries for more than half a century. The accelerator technology of the colliders has progressed immensely, while the beam energy, luminosity, facility size, and cost have grown by several orders of magnitude. The method of colliding beams has not fully exhausted its potential but has slowed down considerably in its progress. In this paper we derive a simple scaling model for the cost of large accelerators and colliding beam facilities based on costs of 17 big facilities which have been either built or carefully estimated. Although this approach cannot replace an actual cost estimate based on an engineering design, this parameterization is to indicate a somewhat realistic cost range for consideration of what future frontier accelerator facilities might be fiscally realizable.

  8. WHAT DRIVES HIGH COST OF FINANCE IN MOLDOVA?

    Directory of Open Access Journals (Sweden)

    Alexandru Stratan

    2012-03-01

    Full Text Available Why there are high costs to finance in Republic of Moldova? Is it a problem for business environment?These are the questions discussed in this paper. Following the well know Growth Diagnostics approach byHausmann, Rodrik and Velasco, authors assess the barriers and impediments to access to finance in Republic ofMoldova. Guided by international and national statistics we found evidence of poor intermediation, poorinstitutions, high level of inflation, and high collateral as major causes of high cost of financial resources inRepublic of Moldova. At the end of the study authors give policy recommendations identifying other related fieldsto be addressed.

  9. A Practical Methodology for Disaggregating the Drivers of Drug Costs Using Administrative Data.

    Science.gov (United States)

    Lungu, Elena R; Manti, Orlando J; Levine, Mitchell A H; Clark, Douglas A; Potashnik, Tanya M; McKinley, Carol I

    2017-09-01

    Prescription drug expenditures represent a significant component of health care costs in Canada, with estimates of $28.8 billion spent in 2014. Identifying the major cost drivers and the effect they have on prescription drug expenditures allows policy makers and researchers to interpret current cost pressures and anticipate future expenditure levels. To identify the major drivers of prescription drug costs and to develop a methodology to disaggregate the impact of each of the individual drivers. The methodology proposed in this study uses the Laspeyres approach for cost decomposition. This approach isolates the effect of the change in a specific factor (e.g., price) by holding the other factor(s) (e.g., quantity) constant at the base-period value. The Laspeyres approach is expanded to a multi-factorial framework to isolate and quantify several factors that drive prescription drug cost. Three broad categories of effects are considered: volume, price and drug-mix effects. For each category, important sub-effects are quantified. This study presents a new and comprehensive methodology for decomposing the change in prescription drug costs over time including step-by-step demonstrations of how the formulas were derived. This methodology has practical applications for health policy decision makers and can aid researchers in conducting cost driver analyses. The methodology can be adjusted depending on the purpose and analytical depth of the research and data availability.

  10. Capital cost: low and high sulfur coal plants; 800 MWe

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    The Commercial Electric Power Cost Study for 800-MWe (Nominal) low- and high-sulfur coal plants consists of three volumes. (This the fourth subject in a series of eight performed in the Commercial Electric Power Cost Studies by the US NRC). The low-sulfur coal plant is described in Volumes I and II (this volume), while Volume III describes the high-sulfur coal plant. The design basis and cost estimate for the 801-MWe low-sulfur coal plant is presented in Volume I and the drawings, equipment list, and site description are contained in this document. The design basis, drawings, and summary cost estimate for a 794-MWe high-sulfur coal plant are presented in Volume III. This information was developed by redesigning the low-sulfur sub-bituminous coal plant for burning high-sulfur bituminous coal. The reference design includes a lime flue gas desulfurization system. These coal plants utilize a mechanical draft (wet) cooling tower system for condenser heat removal. Costs of alternate cooling systems are provided in Report No. 7 in this series of studies of costs of commercial electrical power plants.

  11. High-Efficient Low-Cost Photovoltaics Recent Developments

    CERN Document Server

    Petrova-Koch, Vesselinka; Goetzberger, Adolf

    2009-01-01

    A bird's-eye view of the development and problems of recent photovoltaic cells and systems and prospects for Si feedstock is presented. High-efficient low-cost PV modules, making use of novel efficient solar cells (based on c-Si or III-V materials), and low cost solar concentrators are in the focus of this book. Recent developments of organic photovoltaics, which is expected to overcome its difficulties and to enter the market soon, are also included.

  12. A comparative analysis of the costs of administration of an OSCE (objective structured clinical examination).

    Science.gov (United States)

    Cusimano, M D; Cohen, R; Tucker, W; Murnaghan, J; Kodama, R; Reznick, R

    1994-07-01

    The objective structured clinical examination (OSCE) has become an accepted technique for the evaluation of clinical competence in medicine. Although advances have been made in our knowledge of the psychometric aspects of the OSCE, extremely little has been written about feasibility and cost issues. Given the current economic imperative to control costs and the extremely scant literature on the costs of developing and administering an examination in medicine, the authors felt it timely and relevant to explore issues related to the cost of the OSCE. In 1991-92 and in 1992-93, costs and time requirements to implement and administer a structured oral (SO) examination and a six-station OSCE for a surgical clerkship at the University of Toronto Faculty of Medicine were gathered by review of invoices, interviews with those involved, and perusal of diaries kept by staff. To develop and administer the six-station OSCE, 327.5 hours of staff and faculty time were required for each rotation of surgical clerks (8.2 hours per student). The SO examination required 110 hours of staff and faculty time (2.75 hours per student). Direct expenses for the OSCE amounted to U.S. $6.90 per student per station, compared with no direct expense for the SO examination. The OSCE was more time-consuming and more expensive in human and material costs than the SO examination. However, costs of the OSCE can be substantially reduced from approximately U.S. $35 to U.S. ! per student per station if test developers, standardized patients, support staff, and examiners can donate their time. The authors compare the costs and time requirements of their OSCE with those of other OSCEs reported in the literature, and they provide guidelines to assist educators in deciding whether the costs of an OSCE are justifiable in the educators' individual settings.

  13. Novel Low Cost, High Reliability Wind Turbine Drivetrain

    Energy Technology Data Exchange (ETDEWEB)

    Chobot, Anthony; Das, Debarshi; Mayer, Tyler; Markey, Zach; Martinson, Tim; Reeve, Hayden; Attridge, Paul; El-Wardany, Tahany

    2012-09-13

    Clipper Windpower, in collaboration with United Technologies Research Center, the National Renewable Energy Laboratory, and Hamilton Sundstrand Corporation, developed a low-cost, deflection-compliant, reliable, and serviceable chain drive speed increaser. This chain and sprocket drivetrain design offers significant breakthroughs in the areas of cost and serviceability and addresses the key challenges of current geared and direct-drive systems. The use of gearboxes has proven to be challenging; the large torques and bending loads associated with use in large multi-MW wind applications have generally limited demonstrated lifetime to 8-10 years [1]. The large cost of gearbox replacement and the required use of large, expensive cranes can result in gearbox replacement costs on the order of $1M, representing a significant impact to overall cost of energy (COE). Direct-drive machines eliminate the gearbox, thereby targeting increased reliability and reduced life-cycle cost. However, the slow rotational speeds require very large and costly generators, which also typically have an undesirable dependence on expensive rare-earth magnet materials and large structural penalties for precise air gap control. The cost of rare-earth materials has increased 20X in the last 8 years representing a key risk to ever realizing the promised cost of energy reductions from direct-drive generators. A common challenge to both geared and direct drive architectures is a limited ability to manage input shaft deflections. The proposed Clipper drivetrain is deflection-compliant, insulating later drivetrain stages and generators from off-axis loads. The system is modular, allowing for all key parts to be removed and replaced without the use of a high capacity crane. Finally, the technology modularity allows for scalability and many possible drivetrain topologies. These benefits enable reductions in drivetrain capital cost by 10.0%, levelized replacement and O&M costs by 26.7%, and overall cost of

  14. 42 CFR 412.84 - Payment for extraordinarily high-cost cases (cost outliers).

    Science.gov (United States)

    2010-10-01

    ... outliers). 412.84 Section 412.84 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... Payments for Outlier Cases, Special Treatment Payment for New Technology, and Payment Adjustment for Certain Replaced Devices Payment for Outlier Cases § 412.84 Payment for extraordinarily high-cost cases...

  15. Average System Cost Methodology : Administrator's Record of Decision.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1984-06-01

    Significant features of average system cost (ASC) methodology adopted are: retention of the jurisdictional approach where retail rate orders of regulartory agencies provide primary data for computing the ASC for utilities participating in the residential exchange; inclusion of transmission costs; exclusion of construction work in progress; use of a utility's weighted cost of debt securities; exclusion of income taxes; simplification of separation procedures for subsidized generation and transmission accounts from other accounts; clarification of ASC methodology rules; more generous review timetable for individual filings; phase-in of reformed methodology; and each exchanging utility must file under the new methodology within 20 days of implementation by the Federal Energy Regulatory Commission of the ten major participating utilities, the revised ASC will substantially only affect three. (PSB)

  16. 41 CFR 105-55.016 - Interest, penalties, and administrative costs.

    Science.gov (United States)

    2010-07-01

    ... which the Consumer Price Index for the month of June of the calendar year preceding the adjustment exceeds the Consumer Price Index for the month of June of the calendar year in which the debt was determined or last adjusted. Increases to administrative debts will be computed annually. GSA will use...

  17. 15 CFR 40.4 - Administrative provisions on selection of participants and funding of costs.

    Science.gov (United States)

    2010-01-01

    ... statistical activities of their home country. (c) Arrangements for security clearances, insurance, orientation... PARTICIPANTS IN CENSUS PROCEDURES AND GENERAL STATISTICS § 40.4 Administrative provisions on selection of..., a program for technical training of foreign participants in censuses and statistics. The Bureau...

  18. Three Year Trends in Veterans Health Administration Utilization and Costs after Traumatic Brain Injury Screening among Veterans with Mild Traumatic Brain Injury.

    Science.gov (United States)

    Taylor, Brent C; Hagel Campbell, Emily; Nugent, Sean; Bidelspach, Douglas E; Kehle-Forbes, Shannon M; Scholten, Joel; Stroupe, Kevin T; Sayer, Nina A

    2017-09-01

    Examination of trends in Veterans Health Administration (VHA) healthcare utilization and costs among veterans with mild traumatic brain injury (mTBI) is needed to inform policy, resource allocation, and treatment planning. The objective of this study was to assess the patterns of VHA healthcare utilization and costs in the 3 years following TBI screening among veterans with mTBI, compared with veterans without TBI. A retrospective cohort study of veterans who underwent TBI screening in fiscal year 2010 was conducted. We used VHA healthcare utilization and associated costs by categories of care to compare veterans diagnosed with mTBI (n = 7318) with those who screened negative (n = 75,294) and those who screened positive but had TBI ruled out (n = 3324). Utilization and costs were greatest in year 1, dropped in year 2, and then leveled off. mTBI diagnosis was associated with high rates of utilization. Each year, healthcare costs for those with mTBI were two to three times higher than for those who screened negative, and 20-25% higher than for those who screened positive but had TBI ruled out. A significant proportion of healthcare use and costs for veterans with mTBI were associated with mental health service utilization. The relatively high rate of VHA utilization and costs associated with mTBI over time demonstrates the importance of long-term planning to meet these veterans' needs. Identifying and engaging patients with mTBI in effective mental health treatments should be considered a critical component of treatment planning.

  19. The high cost of low-acuity ICU outliers.

    Science.gov (United States)

    Dahl, Deborah; Wojtal, Greg G; Breslow, Michael J; Holl, Randy; Huguez, Debra; Stone, David; Korpi, Gloria

    2012-01-01

    Direct variable costs were determined on each hospital day for all patients with an intensive care unit (ICU) stay in four Phoenix-area hospital ICUs. Average daily direct variable cost in the four ICUs ranged from $1,436 to $1,759 and represented 69.4 percent and 45.7 percent of total hospital stay cost for medical and surgical patients, respectively. Daily ICU cost and length of stay (LOS) were higher in patients with higher ICU admission acuity of illness as measured by the APACHE risk prediction methodology; 16.2 percent of patients had an ICU stay in excess of six days, and these LOS outliers accounted for 56.7 percent of total ICU cost. While higher-acuity patients were more likely to be ICU LOS outliers, 11.1 percent of low-risk patients were outliers. The low-risk group included 69.4 percent of the ICU population and accounted for 47 percent of all LOS outliers. Low-risk LOS outliers accounted for 25.3 percent of ICU cost and incurred fivefold higher hospital stay costs and mortality rates. These data suggest that severity of illness is an important determinant of daily resource consumption and LOS, regardless of whether the patient arrives in the ICU with high acuity or develops complications that increase acuity. The finding that a substantial number of long-stay patients come into the ICU with low acuity and deteriorate after ICU admission is not widely recognized and represents an important opportunity to improve patient outcomes and lower costs. ICUs should consider adding low-risk LOS data to their quality and financial performance reports.

  20. 76 FR 14659 - Proposed CERCLA AdministrativeCost Recovery” Settlement; The Goldfield Corporation

    Science.gov (United States)

    2011-03-17

    ... of past and projected future response costs concerning the Newton County Mine Tailings Superfund Site in Newton County, Missouri with the following settling party: The Goldfield Corporation. The... Street, Kansas City, KS 66101, 913-551-7567. Comments should reference the Newton County Mine...

  1. Reducing High Absenteeism through Low-Cost Incentives.

    Science.gov (United States)

    North Chaplik, Barbara D.; Engel, Ross A.

    1984-01-01

    Describes a study of the effects of a low-cost incentive program--including daily, weekly, and monthly reinforcements such as attention, approval, and inexpensive awards--on the absenteeism of high-absence employees in an urban school district's transportation department. A 20-percent reduction in absenteeism was achieved. (TE)

  2. Low Cost Lithography Tool for High Brightness LED Manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Andrew Hawryluk; Emily True

    2012-06-30

    The objective of this activity was to address the need for improved manufacturing tools for LEDs. Improvements include lower cost (both capital equipment cost reductions and cost-ofownership reductions), better automation and better yields. To meet the DOE objective of $1- 2/kilolumen, it will be necessary to develop these highly automated manufacturing tools. Lithography is used extensively in the fabrication of high-brightness LEDs, but the tools used to date are not scalable to high-volume manufacturing. This activity addressed the LED lithography process. During R&D and low volume manufacturing, most LED companies use contact-printers. However, several industries have shown that these printers are incompatible with high volume manufacturing and the LED industry needs to evolve to projection steppers. The need for projection lithography tools for LED manufacturing is identified in the Solid State Lighting Manufacturing Roadmap Draft, June 2009. The Roadmap states that Projection tools are needed by 2011. This work will modify a stepper, originally designed for semiconductor manufacturing, for use in LED manufacturing. This work addresses improvements to yield, material handling, automation and throughput for LED manufacturing while reducing the capital equipment cost.

  3. Women Administrators--Is the Price Too High?

    Science.gov (United States)

    Smith, Rosa A.

    1976-01-01

    The woman who wishes to become a school administrator must be prepared to face considerable opposition. She must cope with school attitudes, social inequalities, and possibly an unsupportive spouse. (Editor)

  4. Keep it simple, stupid. Administrative complexity raises costs, frustrates patients and hampers care.

    Science.gov (United States)

    Jessee, William F

    2004-03-01

    The administrative complexity of the U.S. health care system places an enormous wedge between our scientific capability and our performance in serving people promptly, affordably and inclusively. Those adverse effects have eroded public trust in health care and threaten the availability of physicians and other health workers to provide care for a growing and aging population. The author details the problem--and offers a solution.

  5. Resource consumption and healthcare costs of acute coronary syndrome: a retrospective observational administrative database analysis.

    Science.gov (United States)

    Roggeri, Alessandro; Gnavi, Roberto; Dalmasso, Marco; Rusciani, Raffaella; Giammaria, Massimo; Anselmino, Monica; Roggeri, Daniela Paola

    2013-12-01

    The objective of this study was to estimate resource consumption and direct healthcare costs of patients with a first hospitalization for acute coronary syndrome (ACS) in 2008 in the Piedmont Region, Italy. Subjects hospitalized with a first episode of ACS in 2008 were selected from the regional hospital discharge database. All hospitalizations, drug prescriptions, and outpatient episodes of care in the 12 months following discharge were considered to estimate resource consumption and direct healthcare costs from the Piedmont Regional Health Service perspective. The analysis was carried out separately for ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), and unstable angina (UA) populations. In the accrual period, 7765 subjects (1.75‰ of the total population) were hospitalized for ACS (64.2% men). The average age was 66.5 for men and 75.4 for women. The average in-hospital mortality was 6.5% (n = 508). The total ACS population was classified as: STEMI 45.2%, NSTEMI 29.4%, and UA 25.4%. The average yearly costs per patient alive at the end of follow-up (n = 6851) were 14,160.8&OV0556; (18,678.7 USD): 83.9% for inpatient admissions [11,881.2&OV0556; (15,671.8 USD)], 9.3% for drugs [1311.6&OV0556; (1730.1 USD)], 5.0% for diagnostic and therapeutic procedures and outpatient visits [708.2&OV0556; (934.1 USD)], and 1.8% for 1-day hospital stays [259.8&OV0556; (342.7 USD)]. The average yearly direct healthcare costs by ACS event were 14,984.5&OV0556; (19,765.2 USD) for STEMI, 14,554.1&OV0556; (19,197.4 USD) for NSTEMI, and 12,481.5&OV0556; (16,463.6 USD) for UA. In each subpopulation, costs were significantly higher for men than for women. ACS imposes a significant burden in terms of morbidity and mortality and generates major public health service costs.

  6. A high-performance, low-cost, leading edge discriminator

    Indian Academy of Sciences (India)

    S K Gupta; Y Hayashi; A Jain; S Karthikeyan; S Kawakami; K C Ravindran; S C Tonwar

    2005-08-01

    A high-performance, low-cost, leading edge discriminator has been designed with a timing performance comparable to state-of-the-art, commercially available discriminators. A timing error of 16 ps is achieved under ideal operating conditions. Under more realistic operating conditions the discriminator displays a timing error of 90 ps. It has an intrinsic double pulse resolution of 4 ns which is better than most commercial discriminators. A low-cost discriminator is an essential requirement of the GRAPES-3 experiment where a large number of discriminator channels are used.

  7. Low-Cost High-Performance Non-Toxic Self-Pressurizing Storable Liquid Bi-Propellant Pressure-Fed Rocket Engine Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Exquadrum proposes a high-performance liquid bi-propellant rocket engine that uses propellants that are non-toxic, self-pressurizing, and low cost. The proposed...

  8. Philosophy of design for low cost and high reliability

    DEFF Research Database (Denmark)

    Jørgensen, John Leif; Liebe, Carl Christian

    1996-01-01

    The Ørsted Star Imager or Advanced Stellar Compass (ASC), includes the full functionallity of a traditional star tracker plus autonomy, i.e. it is able to quickly and autonomously solve "the lost in space" attitude problem, and determine its attitude with high precision. The design also provides......, Computational speed and Fault detection and recovery substantially. The high performance and low cost design was realized by the use of advanced high level integrated chips, along with a design philosophy of maximum autonomy at all levels. This approach necessitated the use of a prototyping facility which could...... do extensive component testing and screening which addressed the issues of reliability, thermo-mechanical properties, and radiation sensitivity of the commercial IC's. The facility helped to control costs by generating early information on component survival in space. The development philosophy...

  9. 政府成本视角下中国行政审批制度的改革逻辑%The Logic of Chinese Administrative Examination and Approval System Reform in Government Cost Perspective

    Institute of Scientific and Technical Information of China (English)

    张卓

    2015-01-01

    Administrative examination and approval is an important means of governing, but the cost of the operation is high. Improper operation will lead to economic and social welfare loss. From the perspective of government cost, this article focuses on the hidden costs of the administrative examination and approval operates, which is easily to be ignored, analyzing administrative examination and approval hidden costs as the logical starting point, combing the cost variables in operation of the administrative examination, exploring the logic of Chinese administrative examination and approval system reform.%行政审批是政府治理社会的重要手段,但是行政审批的运行不是没有代价的,其运行不当会导致经济和社会福利的减损.本文从政府成本的视角出发,聚焦于行政审批运行产生的、容易被忽略的隐性成本,基于分析政治市场中行政审批产生的隐性成本为逻辑起点,梳理行政审批运行中的各个成本变量,理顺行政审批运行中各成本变量与审改绩效的因果序列,探索中国行政审批制度的改革逻辑.

  10. 行政事业单位成本管理探析%Researches on Cost Management of Administrational Organizations

    Institute of Scientific and Technical Information of China (English)

    刘兰若

    2012-01-01

    行政事业单位的公共性、非营利性和财政性等特征决定了其在成本管理方面存在观念淡泊、成本内容不实、成本列支随意性强、成本开支结构不合理等问题,需要采取强化成本预算管理、加强采购管理、提高国有资产使用效率、完善内部控制制度和建立绩效考评制度等措施来解决。%The cost management of administrational organizations, with its specificity of public, nonprofit and administrational, would be needed to strengthen on its budget management, procurement management to enhance efficiency of national-owned cap- ital and improve internal controlling system and establish performance -efficiency evaluation system to resolve the problems that have existed in the cost management of the organizations.

  11. Access to high cost medicines in Australia: ethical perspectives.

    Science.gov (United States)

    Lu, Christine Y; Macneill, Paul; Williams, Ken; Day, Ric

    2008-05-19

    Access to "high cost medicines" through Australia's Pharmaceutical Benefits Scheme (PBS) is tightly regulated. It is inherently difficult to apply any criteria-based system of control in a way that provides a fair balance between efficient use of limited resources for community needs and equitable individual access to care. We suggest, in relation to very high cost medicines, that the present arrangements be re-considered in order to overcome potential inequities. The biological agents for the treatment of rheumatoid arthritis are used as an example by which to discuss the ethical issues associated with the current scheme. Consideration of ethical aspects of the PBS and similar programs is important in order to achieve the fairest outcomes for individual patients, as well as for the community.

  12. Norplant's high cost may prohibit use in Title 10 clinics.

    Science.gov (United States)

    1991-04-01

    The article discusses the prohibitive cost of Norplant for the Title 10 low-income population served in public family planning clinics in the U.S. It is argued that it's unfair for U.S. users to pay $350 to Wyeth- Ayerst when another pharmaceutical company provides developing countries with Norplant at a cost of $14 - 23. Although the public sector and private foundations funded the development, it was explained that the company needs to recoup the investment in training and education. Medicaid and third party payers such as insurance companies will reimburse for the higher price, but if the public sector price is lowered, then the company would not make a profit and everyone would have argued for the reimbursement at the lower cost. It was suggested that a boycott of American Home Products, Wyeth-Ayerst's parent company, be made. Public family planning providers who are particularly low in funding reflect that their budget of $30,000 would only provide 85 users, and identified in this circumstance by drug abusers and multiple pregnancy women, and the need for teenagers remains unfulfilled. Another remarked that the client population served is 4700 with $54,000 in funding, which is already accounted for. The general trend of comments was that for low income women the cost is to high.

  13. 国内行政决策成本研究综述%Review of Domestic Administrative Decision-making Costs

    Institute of Scientific and Technical Information of China (English)

    左雪

    2012-01-01

    Based on the arrangement of the cost of administrative decision documents in recent decade, the writer analysis the content, reason and factors which could affect the cost of administrative decision and points the methods of optimizing the cost of administrative decision. In the meantime, the writer points some problems which needs to be solved, especially clear the relationship between the cost of administrative decision and governmental-administration cost that is administrative decision cost is not only the part of governmental administration cost, and itself as a existence of the whole which affect the governmental administration cost in turn.%基于对近十年关于行政决策成本文献的梳理,分析了行政决策成本的内容、过高的原因和影响行政决策成本的因素,指出了优化行政决策成本的途径。与此同时,提出了一些有待解决的问题,尤其是理清了行政决策成本与政府行政成本的关系,指出了行政决策成本不仅是政府行政成本的重要组成部分,它本身也作为一个整体存在,影响着政府行政成本。

  14. Coverage Options for a Low cost, High Resolution Optical Constellation

    OpenAIRE

    Price, M E; Levett, W.; Graham, K.

    2003-01-01

    This paper presents the range of coverage options available to TopSat like small satellites, both singly and in a small constellation. TopSat is a low-cost, high resolution and image quality, optical small satellite, due for launch in October 2004. In particular, the paper considers the use of tuned, repeat ground track orbits to improve coverage for selected ground targets, at the expense of global coverage. TopSat is designed to demonstrate the capabilities of small satellites for high valu...

  15. Patents associated with high-cost drugs in Australia.

    Directory of Open Access Journals (Sweden)

    Andrew F Christie

    Full Text Available Australia, like most countries, faces high and rapidly-rising drug costs. There are longstanding concerns about pharmaceutical companies inappropriately extending their monopoly position by "evergreening" blockbuster drugs, through misuse of the patent system. There is, however, very little empirical information about this behaviour. We fill the gap by analysing all of the patents associated with 15 of the costliest drugs in Australia over the last 20 years. Specifically, we search the patent register to identify all the granted patents that cover the active pharmaceutical ingredient of the high-cost drugs. Then, we classify the patents by type, and identify their owners. We find a mean of 49 patents associated with each drug. Three-quarters of these patents are owned by companies other than the drug's originator. Surprisingly, the majority of all patents are owned by companies that do not have a record of developing top-selling drugs. Our findings show that a multitude of players seek monopoly control over innovations to blockbuster drugs. Consequently, attempts to control drug costs by mitigating misuse of the patent system are likely to miss the mark if they focus only on the patenting activities of originators.

  16. The High Value CVT Concept--Cost Effective and Powerful

    Institute of Scientific and Technical Information of China (English)

    A. Englisch,; A. Teubert; A. Gotz; E. Muller; E. Simon; B. Walter; A. Baumgartner

    2011-01-01

    Based on the comprehensive comparison of vehicle performance in economy,engine power,driving smoothness,and efficiency cost as well as pollutant emission etc,the paper discussed the high value CVT concept from an angle of the cost effective and powerful for vehicle.In the paper,it researched the related technical detail in CVT.By means of realizing the continuous change in transmission ratio,it could obtain the optimal matching between transmission system and engine operating mode,and enhance the characteristic of fuel oil in economy,and also improve the convenience in manipulation for driver and make passenger comfortable.For easy to understand the concept,the paper made the comparison analysis in many aspects such as performance,transmission specification,high value CVT hybrid,orifice torque sensor,hydraulic system,high value CVT em,new chain portfolio and assessment of the high value CVT on the NEDC.Finally it showed the potential advantages of CVT technology development,and proposed future developing trends to realize technical scheme of high value CVT.

  17. Evaluation of the Mean Cost and Activity Based Cost in the Diagnosis of Pulmonary Tuberculosis in the Laboratory Routine of a High-Complexity Hospital in Brazil.

    Science.gov (United States)

    de Almeida, Isabela N; de Assis Figueredo, Lida J; Soares, Valéria M; Vater, Maria C; Alves, Suely; da Silva Carvalho, Wânia; Kritski, Afrânio L; de Miranda, Silvana S

    2017-01-01

    At a global level, with the increase in healthcare costs, there is a need to assess the economic impact of the incorporation of new technologies in different health disorders in different countries. There is scarce information regarding costs incurred with the use of current or new diagnostic tests for tuberculosis or from the vantage point of their incorporation within the healthcare systems of high-burden countries. The present study aimed to assess the mean cost and the activity based cost of the laboratory diagnosis for tuberculosis by means of conventional techniques and from the Detect TB(®)LabTest molecular test kit in a general high-complexity hospital of the public health system in Brazil. Cost analysis was performed by means of primary data, collected in the Mycobacteria and Molecular Biology Laboratory in 2013. The mean cost and activity based cost were, respectively, U$10.06/U$5.61 for centrifuged bacilloscopy by Ziehl Neelsen (ZN) and Auramine (AU); U$7.42/U$4.15 for direct bacilloscopy by ZN; U$27.38/U$16.50 for culture in a Loweinstein-Jensen solid medium; and U$115.74/U$73.46 for the Detect TB(®)LabTest Kit. The calculation of the ABC should be used in making decisions by administrators to be the best method of assessing the costs of conventional techniques and molecular method for providing the real value of the tests. So it is need to calculate the ABC, and not of the mean cost, in various scenarios before incorporating new technologies in health institutions.

  18. Evaluation of the Mean Cost and Activity Based Cost in the Diagnosis of Pulmonary Tuberculosis in the Laboratory Routine of a High-Complexity Hospital in Brazil

    Science.gov (United States)

    de Almeida, Isabela N.; de Assis Figueredo, Lida J.; Soares, Valéria M.; Vater, Maria C.; Alves, Suely; da Silva Carvalho, Wânia; Kritski, Afrânio L.; de Miranda, Silvana S.

    2017-01-01

    At a global level, with the increase in healthcare costs, there is a need to assess the economic impact of the incorporation of new technologies in different health disorders in different countries. There is scarce information regarding costs incurred with the use of current or new diagnostic tests for tuberculosis or from the vantage point of their incorporation within the healthcare systems of high-burden countries. The present study aimed to assess the mean cost and the activity based cost of the laboratory diagnosis for tuberculosis by means of conventional techniques and from the Detect TB®LabTest molecular test kit in a general high-complexity hospital of the public health system in Brazil. Cost analysis was performed by means of primary data, collected in the Mycobacteria and Molecular Biology Laboratory in 2013. The mean cost and activity based cost were, respectively, U$10.06/U$5.61 for centrifuged bacilloscopy by Ziehl Neelsen (ZN) and Auramine (AU); U$7.42/U$4.15 for direct bacilloscopy by ZN; U$27.38/U$16.50 for culture in a Loweinstein-Jensen solid medium; and U$115.74/U$73.46 for the Detect TB®LabTest Kit. The calculation of the ABC should be used in making decisions by administrators to be the best method of assessing the costs of conventional techniques and molecular method for providing the real value of the tests. So it is need to calculate the ABC, and not of the mean cost, in various scenarios before incorporating new technologies in health institutions. PMID:28261194

  19. Stochastic Funding of a Defined Contribution Pension Plan with Proportional Administrative Costs and Taxation under Mean-Variance Optimization Approach

    Directory of Open Access Journals (Sweden)

    Charles I Nkeki

    2014-11-01

    Full Text Available This paper aim at studying a mean-variance portfolio selection problem with stochastic salary, proportional administrative costs and taxation in the accumulation phase of a defined contribution (DC pension scheme. The fund process is subjected to taxation while the contribution of the pension plan member (PPM is tax exempt. It is assumed that the flow of contributions of a PPM are invested into a market that is characterized by a cash account and a stock. The optimal portfolio processes and expected wealth for the PPM are established. The efficient and parabolic frontiers of a PPM portfolios in mean-variance are obtained. It was found that capital market line can be attained when initial fund and the contribution rate are zero. It was also found that the optimal portfolio process involved an inter-temporal hedging term that will offset any shocks to the stochastic salary of the PPM.

  20. A cost of sexual attractiveness to high-fitness females.

    Directory of Open Access Journals (Sweden)

    Tristan A F Long

    2009-12-01

    Full Text Available Adaptive mate choice by females is an important component of sexual selection in many species. The evolutionary consequences of male mate preferences, however, have received relatively little study, especially in the context of sexual conflict, where males often harm their mates. Here, we describe a new and counterintuitive cost of sexual selection in species with both male mate preference and sexual conflict via antagonistic male persistence: male mate choice for high-fecundity females leads to a diminished rate of adaptive evolution by reducing the advantage to females of expressing beneficial genetic variation. We then use a Drosophila melanogaster model system to experimentally test the key prediction of this theoretical cost: that antagonistic male persistence is directed toward, and harms, intrinsically higher-fitness females more than it does intrinsically lower-fitness females. This asymmetry in male persistence causes the tails of the population's fitness distribution to regress towards the mean, thereby reducing the efficacy of natural selection. We conclude that adaptive male mate choice can lead to an important, yet unappreciated, cost of sex and sexual selection.

  1. High Performance, Low Cost Hydrogen Generation from Renewable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Ayers, Katherine [Proton OnSite; Dalton, Luke [Proton OnSite; Roemer, Andy [Proton OnSite; Carter, Blake [Proton OnSite; Niedzwiecki, Mike [Proton OnSite; Manco, Judith [Proton OnSite; Anderson, Everett [Proton OnSite; Capuano, Chris [Proton OnSite; Wang, Chao-Yang [Penn State University; Zhao, Wei [Penn State University

    2014-02-05

    Renewable hydrogen from proton exchange membrane (PEM) electrolysis is gaining strong interest in Europe, especially in Germany where wind penetration is already at critical levels for grid stability. For this application as well as biogas conversion and vehicle fueling, megawatt (MW) scale electrolysis is required. Proton has established a technology roadmap to achieve the necessary cost reductions and manufacturing scale up to maintain U.S. competitiveness in these markets. This project represents a highly successful example of the potential for cost reduction in PEM electrolysis, and provides the initial stack design and manufacturing development for Proton’s MW scale product launch. The majority of the program focused on the bipolar assembly, from electrochemical modeling to subscale stack development through prototyping and manufacturing qualification for a large active area cell platform. Feasibility for an advanced membrane electrode assembly (MEA) with 50% reduction in catalyst loading was also demonstrated. Based on the progress in this program and other parallel efforts, H2A analysis shows the status of PEM electrolysis technology dropping below $3.50/kg production costs, exceeding the 2015 target.

  2. Research on Management Innovation for the Hospitals’ Administrative Cost Based on Activity-Based Costing%基于作业成本法的医院管理费用管理创新研究

    Institute of Scientific and Technical Information of China (English)

    赵秀贞; 赵一林; 杨树国; 程寿锦

    2013-01-01

    Objective: To seek the best management model for effective control of the hospitals ’ administrative cost. Methods:According to the problems in hospital administrative cost based on traditional cost method , activity-based costing method is used to establish cost drivers. According to cost accounting system of cost accounting model development , it creates cost accounting model and completes collation and scientific allocation of the administrative cost. Therefore it provides accurate cost information and control path for the hospitals to establish internal control measures and analyze the control effect of administrative cost by comparing with rank sum ratio (RSR) method. Results: Using activity-based costing to control hospitals’ administrative cost is more remarkable than traditional cost method. Conclusion: The activity-based costing is one of the most reasonable and effective ways for the hospitals ’ cost accounting and control.%目的:为有效管理控制医院管理费寻求最佳管理模式。方法:针对传统成本法在医院管理费用管理上存在的问题,采用作业成本法确立成本动因,依据成本核算模型开发成本核算系统,完成管理费用的合理归集和科学分摊,从而为医院制定内部控制措施提供准确成本信息和控制路径,并用秩和比法对管理费用的控制效果进行了对比分析。结果:控制医院管理费用作业成本法较传统成本法效果显著。结论:作业成本法是医院成本核算和控制最合理、最有效的方法之一。

  3. Long-term globular adiponectin administration improves adipose tissue dysmetabolism in high-fat diet-fed Wistar rats.

    Science.gov (United States)

    Matafome, P; Rodrigues, T; Pereira, A; Letra, L; Azevedo, H; Paixão, A; Silvério, M; Almeida, A; Sena, C; Seiça, R

    2014-10-01

    Adiponectin administration to obese or type 2 diabetic patients is still far off, due to its expensive costs and absence of studies demonstrating the effectiveness of its chronic administration. We performed long-term globular adiponectin administration, testing its usefulness in improving adipose tissue metabolism. Adiponectin (98 υg/day) was administered through a subcutaneous minipump with continued release (28 days) to Wistar rats fed a high-fat diet. Adiponectin decreased body weight and adipocyte size, while decreasing circulating leptin levels. More, adiponectin was able to increase IkappaBalpha and PPARgamma levels and to prevent high-fat diet-induced impairment of insulin signalling, especially in epididymal adipose tissue. This resulted in improved glucose profile. High-fat diet caused an impairment of lipolysis in epididymal adipose tissue, which was partially restored by adiponectin treatment. Long-term globular adiponectin administration was able to improve pathways of insulin signalling and lipid storage in adipose tissue of high-fat diet-fed rats, contributing to a better metabolic profile.

  4. A Low-Cost, High-Precision Navigator for Unmanned Aircraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Toyon Research Corporation proposes to develop a low-cost navigation system for unmanned aerial vehicles (UAVs) that achieves an attitude accuracy of better than 0.1...

  5. The costs and cost-efficiency of providing food through schools in areas of high food insecurity.

    Science.gov (United States)

    Gelli, Aulo; Al-Shaiba, Najeeb; Espejo, Francisco

    2009-03-01

    The provision of food in and through schools has been used to support the education, health, and nutrition of school-aged children. The monitoring of financial inputs into school health and nutrition programs is critical for a number of reasons, including accountability, transparency, and equity. Furthermore, there is a gap in the evidence on the costs, cost-efficiency, and cost-effectiveness of providing food through schools, particularly in areas of high food insecurity. To estimate the programmatic costs and cost-efficiency associated with providing food through schools in food-insecure, developing-country contexts, by analyzing global project data from the World Food Programme (WFP). Project data, including expenditures and number of schoolchildren covered, were collected through project reports and validated through WFP Country Office records. Yearly project costs per schoolchild were standardized over a set number of feeding days and the amount of energy provided by the average ration. Output metrics, such as tonnage, calories, and micronutrient content, were used to assess the cost-efficiency of the different delivery mechanisms. The average yearly expenditure per child, standardized over a 200-day on-site feeding period and an average ration, excluding school-level costs, was US$21.59. The costs varied substantially according to choice of food modality, with fortified biscuits providing the least costly option of about US$11 per year and take-home rations providing the most expensive option at approximately US$52 per year. Comparisons across the different food modalities suggested that fortified biscuits provide the most cost-efficient option in terms of micronutrient delivery (particularly vitamin A and iodine), whereas on-site meals appear to be more efficient in terms of calories delivered. Transportation and logistics costs were the main drivers for the high costs. The choice of program objectives will to a large degree dictate the food modality

  6. High-temperature superconducting transformer performance, cost, and market evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Dirks, J.A.; Dagle, J.E.; DeSteese, J.G.; Huber, H.D.; Smith, S.A.; Currie, J.W. [Pacific Northwest Lab., Richland, WA (United States); Merrick, S.B. [Westinghouse Hanford Co., Richland, WA (United States); Williams, T.A. [National Renewable Energy Lab., Golden, CO (United States)

    1993-09-01

    Recent laboratory breakthroughs in high-temperature superconducting (HTS) materials have stimulated both the scientific community and general public with questions regarding how these materials can be used in practical applications. While there are obvious benefits from using HTS materials (most notably the potential for reduced energy losses in the conductors), a number of issues (such as overall system energy losses, cost, and reliability) may limit applications of HTS equipment, even if the well known materials problems are solved. This study examined the future application potential of HTS materials to power transformers. This study effort was part of a US Department of Energy (DOE) Office of Energy Storage and Distribution (OESD) research program, Superconductivity Technology for Electric Power Systems (STEPS). The study took a systems perspective to gain insights to help guide DOE in managing research designed to realize the vision of HTS applications. Specific objectives of the study were as follows: to develop an understanding of the fundamental HTS transformer design issues that can provide guidance for developing practical devices of interest to the electric utility industry; to identify electric utility requirements for HTS transformers and to evaluate the potential for developing a commercial market; to evaluate the market potential and national benefits for HTS transformers that could be achieved by a successful HTS development program; to develop an integrated systems analysis framework, which can be used to support R&D planning by DOE, by identifying how various HTS materials characteristics impact the performance, cost, and national benefits of the HTS application.

  7. 论行政后勤类成本在医院成本核算中的分摊%Discussion on the Administrative Cost Apportionments in Hospital Cost Accounting

    Institute of Scientific and Technical Information of China (English)

    张娜

    2015-01-01

    目的:准确地界定成本责任,进而建立更有效的行政后勤类成本控制机制。方法通过了解行政后勤类成本现状,分析行政后勤类成本分摊的优势和不足,寻找有效的解决办法。结果与结论通过临床科室的监督和合理的成本预算制度,提高行政后勤科室自我成本管控意识。%Objective To accurately define the cost responsibility and establish a more effective adminis-trative logistics cost control mechanism .Methods Understanding present situation of the administrative logistics cost, analyzing the advantages and disadvantages of cost apportionments in administrative logistics to find effective solutions .Results and Conclusion With the combination of clinical departments supervision and reasonable cost budget system , administrative departments'self-consciousness of cost control could be improved .

  8. Mine Cost Can Hardly Be Lowered Due To High Percentage Of Inflexible Costs For Lead & Zinc Mine Enterprises

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    At the 2016(11th)Shanghai Lead&Zinc Summit,Lian Chuanshuang from Tibet Huayu Mining explained the current operation condition of domestic mine enterprises.At the Summit,he pointed out that currently mine cost could hardly be reduced,the main reason is too high percentage of inflexible cost.

  9. Surgical site infections : how high are the costs?

    NARCIS (Netherlands)

    Broex, E. C. J.; van Asselt, A. D. I.; Bruggeman, C. A.; van Tiel, F. H.

    2009-01-01

    There is an increased interest in prevention of nosocomial. infections and in the potential, savings in healthcare costs. The aim of this review of recent studies on surgical site infections (SSIs) was to compare methods of cost research and magnitudes of costs due to SSI. The studies reviewed diffe

  10. Surgical site infections : how high are the costs?

    NARCIS (Netherlands)

    Broex, E. C. J.; van Asselt, A. D. I.; Bruggeman, C. A.; van Tiel, F. H.

    There is an increased interest in prevention of nosocomial. infections and in the potential, savings in healthcare costs. The aim of this review of recent studies on surgical site infections (SSIs) was to compare methods of cost research and magnitudes of costs due to SSI. The studies reviewed

  11. Bridging the Silos of Service Delivery for High-Need, High-Cost Individuals.

    Science.gov (United States)

    Sherry, Melissa; Wolff, Jennifer L; Ballreich, Jeromie; DuGoff, Eva; Davis, Karen; Anderson, Gerard

    2016-12-01

    Health care reform efforts that emphasize value have increased awareness of the importance of nonmedical factors in achieving better care, better health, and lower costs in the care of high-need, high-cost individuals. Programs that care for socioeconomically disadvantaged, high-need, high-cost individuals have achieved promising results in part by bridging traditional service delivery silos. This study examined 5 innovative community-oriented programs that are successfully coordinating medical and nonmedical services to identify factors that stimulate and sustain community-level collaboration and coordinated care across silos of health care, public health, and social services delivery. The authors constructed a conceptual framework depicting community health systems that highlights 4 foundational factors that facilitate community-oriented collaboration: flexible financing, shared leadership, shared data, and a strong shared vision of commitment toward delivery of person-centered care.

  12. High resolution, low cost solar cell contact development

    Science.gov (United States)

    Mardesich, N.

    1981-01-01

    The MIDFILM cell fabrication and encapsulation processes were demonstrated as a means of applying low-cost solar cell collector metallization. The average cell efficiency of 12.0 percent (AM1, 28 C) was achieved with fritted silver metallization with a demonstration run of 500 starting wafers. A 98 percent mechanical yield and 80 percent electrical yield were achieved through the MIDFILM process. High series resistance was responsible for over 90 percent of the electrical failures and was the major factor causing the low average cell efficiency. Environmental evaluations suggest that the MIDFILM cells do not degrade. A slight degradation in power was experienced in the MIDFILM minimodules when the AMP Solarlok connector delaminated during the environmental testing.

  13. Effects of high-involvement work systems on employee satisfaction and service costs in veterans healthcare.

    Science.gov (United States)

    Harmon, Joel; Scotti, Dennis J; Behson, Scott; Farias, Gerard; Petzel, Robert; Neuman, Joel H; Keashly, Loraleigh

    2003-01-01

    Two strong imperatives for healthcare managers are reducing costs of service and attracting and retaining highly dedicated and competent patient care and support employees. Is there a trade-off or are there organizational practices that can further both objectives at the same time? High-involvement work systems (HIWS) represent a holistic work design that includes interrelated core features such as involvement, empowerment, development, trust, openness, teamwork, and performance-based rewards. HIWS have been linked to higher productivity, quality, employee and customer satisfaction, and market and financial performance in Fortune 1000 firms. Apparently, few prior studies have looked at the impacts of this holistic design within the healthcare sector. This research found that HIWS were associated with both greater employee satisfaction and lower patient service costs in 146 Veterans Health Administration centers, indicating that such practices pay off in both humanistic and financial terms. This suggests that managers implementing HIWS will incur real expenses that are likely to be more than offset by more satisfied employees, less organizational turmoil, and lower service delivery costs, which, in this study, amounted to over $1.2 million in savings for an average VHA facility.

  14. Offshore compression system design for low cost high and reliability

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Carlos J. Rocha de O.; Carrijo Neto, Antonio Dias; Cordeiro, Alexandre Franca [Chemtech Engineering Services and Software Ltd., Rio de Janeiro, RJ (Brazil). Special Projects Div.], Emails: antonio.carrijo@chemtech.com.br, carlos.rocha@chemtech.com.br, alexandre.cordeiro@chemtech.com.br

    2010-07-01

    In the offshore oil fields, the oil streams coming from the wells usually have significant amounts of gas. This gas is separated at low pressure and has to be compressed to the export pipeline pressure, usually at high pressure to reduce the needed diameter of the pipelines. In the past, this gases where flared, but nowadays there are a increasing pressure for the energy efficiency improvement of the oil rigs and the use of this gaseous fraction. The most expensive equipment of this kind of plant are the compression and power generation systems, being the second a strong function of the first, because the most power consuming equipment are the compressors. For this reason, the optimization of the compression system in terms of efficiency and cost are determinant to the plant profit. The availability of the plants also have a strong influence in the plant profit, specially in gas fields where the products have a relatively low aggregated value, compared to oil. Due this, the third design variable of the compression system becomes the reliability. As high the reliability, larger will be the plant production. The main ways to improve the reliability of compression system are the use of multiple compression trains in parallel, in a 2x50% or 3x50% configuration, with one in stand-by. Such configurations are possible and have some advantages and disadvantages, but the main side effect is the increase of the cost. This is the offshore common practice, but that does not always significantly improve the plant availability, depending of the previous process system. A series arrangement and a critical evaluation of the overall system in some cases can provide a cheaper system with equal or better performance. This paper shows a case study of the procedure to evaluate a compression system design to improve the reliability but without extreme cost increase, balancing the number of equipment, the series or parallel arrangement, and the driver selection. Two cases studies will be

  15. Analysis of Current Situation and Path Optimization of Administration Cost in China%我国行政成本现状分析及优化路径

    Institute of Scientific and Technical Information of China (English)

    张金融

    2011-01-01

    One of the important ways for current administrative system reform is to control and optimize administration cost.This paper adopts relevant theories of public administration and financial expenditure,analyzes the situation of administration costs expansi%控制和优化行政成本是我国当前行政体制改革的重要内容和途径之一。本文运用公共管理和财政支出的相关理论,对我国行政成本扩张、结构和收益等现状进行分析,对行政成本发展趋势做出判断,并提出控制和优化行政成本的路径选择。

  16. High performance of low cost soft magnetic materials

    Indian Academy of Sciences (India)

    Josefina M Silveyra; Emília Illeková; Marco Coïsson; Federica Celegato; Franco Vinai; Paola Tiberto; Javier A Moya; Victoria J Cremaschi

    2011-12-01

    The consistent interest in supporting research and development of magnetic materials during the last century is revealed in their steadily increasing market. In this work, the soft magnetic nanocrystalline FINEMET alloy was prepared with commercial purity raw materials and compared for the first time with the generally studied high purity one. The exhaustive characterization covers several diverse techniques: X-ray diffraction, Mössbauer spectroscopy, differential scanning calorimetry, differential thermal analysis and magnetic properties. In addition, a brief economic analysis is presented. For the alloys annealed at 813 K, the value of the grain size was 16 nm with 19.5% of Si, the coercivity was 0.30 A m-1 while the saturation was 1.2 T. These results prove that structural, magnetic and thermal properties of this material are very close to the expensive high purity FINEMET alloy, while a cost reduction of almost 98% seems highly attractive for laboratories and industry. The analysis should be useful not only for the production of FINEMETs, but for other type of systems with similar constitutive elements as well, including soft and hard magnetic materials.

  17. Low cost, high temperature membranes for PEM fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-08-15

    This report details the results of a project to develop novel, low-cost high temperature membranes specifically for automotive fuel cell use. The specific aim of the project was to determine whether a polyaromatic hydrocarbon membrane could be developed that would give a performance (0.68V at 500 mAcm{sub -2}) competitive with an established perfluoronated sulfonic acid (PSA) membrane in a fuel cell at 120{sup o}C and relative humidity of less than 50%. The novel approach used in this project was to increase the concentration of sulphonic groups to a useful level without dissolution by controlling the molecular structure of the membrane through the design of the monomer repeat unit. The physicochemical properties of 70 polymers synthesised in order to determine the effects of controlled sequence distribution were identified using an array of analytical techniques. Appropriate membranes were selected for fuel cell testing and fabricated into membrane electrode assemblies. Most of the homopolymers tested were able to withstand low humidity environments without immediate catastrophic failure and some showed promise from accelerated durability results. The properties of a simple starting polymer structure were found to be enhanced by doping with sulphonated copper phthalocyanine, resulting in high temperature capacity from a potential cheap, simple and scaleable process. The accelerated and long-term durability of such a doped polymer membrane showed that polyaromatics could easily outperform fluoropolymers under high temperature (120{sup o}C) operating conditions.

  18. Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting.

    Science.gov (United States)

    Bartsch, Sarah M; Hotez, Peter J; Hertenstein, Daniel L; Diemert, David J; Zapf, Kristina M; Bottazzi, Maria Elena; Bethony, Jeffrey M; Brown, Shawn T; Lee, Bruce Y

    2016-04-27

    Although mass drug administration (MDA) has helped reduce morbidity attributed to soil-transmitted helminth infections in children, its limitations for hookworm infection have motivated the development of a human hookworm vaccine to both improve morbidity control and ultimately help block hookworm transmission leading to elimination. However, the potential economic and epidemiologic impact of a preventive vaccine has not been fully evaluated. We developed a dynamic compartment model coupled to a clinical and economics outcomes model representing both the human and hookworm populations in a high transmission region of Brazil. Experiments simulated different implementation scenarios of MDA and vaccination under varying circumstances. Considering only intervention costs, both annual MDA and vaccination were highly cost-effective (ICERs ≤ $790/DALY averted) compared to no intervention, with vaccination resulting in lower incremental cost-effectiveness ratios (ICERs ≤ $444/DALY averted). From the societal perspective, vaccination was economically dominant (i.e., less costly and more effective) versus annual MDA in all tested scenarios, except when vaccination was less efficacious (20% efficacy, 5 year duration) and MDA coverage was 75%. Increasing the vaccine's duration of protection and efficacy, and including a booster injection in adulthood all increased the benefits of vaccination (i.e., resulted in lower hookworm prevalence, averted more disability-adjusted life years, and saved more costs). Assuming its target product profile, a pediatric hookworm vaccine drastically decreased hookworm prevalence in children to 14.6% after 20 years, compared to 57.2% with no intervention and 54.1% with MDA. The addition of a booster in adulthood further reduced the overall prevalence from 68.0% to 36.0% and nearly eliminated hookworm infection in children. Using a human hookworm vaccine would be cost-effective and in many cases economically dominant, providing both health

  19. Research on the Cost of Government Administration%基于改善民生目标下降低政府行政成本的研究

    Institute of Scientific and Technical Information of China (English)

    林菡馨

    2012-01-01

    当前我国政府行政成本不断增长,已远远超过世界其他国家,因此对降低政府行政成本的研究不仅有利于提高政府行政效率、保障和改善民生,更有利于促进社会稳定及公平正义。根据对政府行政成本的分析,探讨造成行政成本较高的原因,提出绩效评估全面化、成本意识深入化、政府结构合理化、行政决策科学化来降低行政成本的具体措施。%The cost of government administration is increasing rapidly. So it's significant to start researching on decreasing the cost of government administration. Decrease of the cost of government administration will be beneficial for government to improve efficiency of administration and value people's live, even to attain social fairness and justice. Based on analysis of the cost of government administration, this paper puts forward several practical measures.

  20. Capital cost: high and low sulfur coal plants-1200 MWe. [High sulfur coal

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    This Commercial Electric Power Cost Study for 1200 MWe (Nominal) high and low sulfur coal plants consists of three volumes. The high sulfur coal plant is described in Volumes I and II, while Volume III describes the low sulfur coal plant. The design basis and cost estimate for the 1232 MWe high sulfur coal plant is presented in Volume I, and the drawings, equipment list and site description are contained in Volume II. The reference design includes a lime flue gas desulfurization system. A regenerative sulfur dioxide removal system using magnesium oxide is also presented as an alternate in Section 7 Volume II. The design basis, drawings and summary cost estimate for a 1243 MWe low sulfur coal plant are presented in Volume III. This information was developed by redesigning the high sulfur coal plant for burning low sulfur sub-bituminous coal. These coal plants utilize a mechanical draft (wet) cooling tower system for condenser heat removal. Costs of alternate cooling systems are provided in Report No. 7 in this series of studies of costs of commercial electrical power plants.

  1. Cost of malingering mild traumatic brain injury-related cognitive deficits during compensation and pension evaluations in the veterans benefits administration.

    Science.gov (United States)

    Denning, John H; Shura, Robert D

    2017-08-17

    Given the high rates of exaggeration in those claiming long-term cognitive deficits as a result of mild traumatic brain injury (mTBI), the aim of this study was to evaluate the rates of malingering in those seeking disability through the Veterans Benefits Administration and estimate the financial burden of disability payments for those receiving compensation despite exaggerated mTBI-related cognitive deficits. Retrospective review included 74 veterans seen for Compensation and Pension evaluations for mTBI. Rates of malingering were based on failure of the Medical Symptom Validity Test (MSVT) and/or the Test of Memory Malingering (TOMM) trial 1 ≤ 40. Total estimated compensation was based on the level of disability awarded and the number of individuals found to be malingering cognitive deficits. Overall, 33-52% of the sample was found to be malingering mTBI-related cognitive deficits. The malingering groups were receiving approximately $71,000-$121,000/year ($6,390-$7,063 per year, per veteran on average). Estimated nationwide disability payments for those possibly malingering mTBI-related cognitive deficits would be $136-$235 million/year (projected costs from 2015-2020 = $700 million-$1.2 billion). It is critical that providers and administrative officials identify those exaggerating disability claims attributed to mTBI. The cost of malingering impacts society in general as well as veterans themselves, as it diverts needed funds/resources away from those legitimately impaired by their military service.

  2. Low-Cost, Rugged High-Vacuum System

    Science.gov (United States)

    Sorensen, Paul; Kline-Schoder, Robert

    2012-01-01

    A need exists for miniaturized, rugged, low-cost high-vacuum systems. Recent advances in sensor technology have led to the development of very small mass spectrometer detectors as well as other analytical instruments such as scanning electron microscopes. However, the vacuum systems to support these sensors remain large, heavy, and power-hungry. To meet this need, a miniaturized vacuum system was developed based on a very small, rugged, and inexpensive-to-manufacture molecular drag pump (MDP). The MDP is enabled by a miniature, very-high-speed (200,000 rpm), rugged, low-power, brushless DC motor optimized for wide temperature operation and long life. The key advantages of the pump are reduced cost and improved ruggedness compared to other mechanical hig-hvacuum pumps. The machining of the rotor and stators is very simple compared to that necessary to fabricate rotor and stator blades for other pump designs. Also, the symmetry of the rotor is such that dynamic balancing of the rotor will likely not be necessary. Finally, the number of parts in the unit is cut by nearly a factor of three over competing designs. The new pump forms the heart of a complete vacuum system optimized to support analytical instruments in terrestrial applications and on spacecraft and planetary landers. The MDP achieves high vacuum coupled to a ruggedized diaphragm rough pump. Instead of the relatively complicated rotor and stator blades used in turbomolecular pumps, the rotor in the MDP consists of a simple, smooth cylinder of aluminum. This will turn at approximately 200,000 rpm inside an outer stator housing. The pump stator comprises a cylindrical aluminum housing with one or more specially designed grooves that serve as flow channels. To minimize the length of the pump, the gas is forced down the flow channels of the outer stator to the base of the pump. The gas is then turned and pulled toward the top through a second set of channels cut into an inner stator housing that surrounds the

  3. Low cost and high performance screen laminate regenerator matrix

    Energy Technology Data Exchange (ETDEWEB)

    Bin-Nun, Uri; Manitakos, Dan [FLIR Systems, North Billerica, MA (United States)

    2004-08-01

    A laminate screen matrix regenerator with 47 elements has been designed, analyzed, fabricated and tested. The laminate was fabricated from stainless steel screen sheets that were stacked on top of each other at certain angular orientation and then bonded at high temperature and pressure environment utilizing a sintering process. This laminate is a porous structure media with highly repeatable properties that can be controlled by varying mesh size, weave type, wire size and laminate sheet to sheet orientation. The flow direction in relation to the weave plan can be varied by cutting a cylindrical or rectangular laminate element along or across the weave. The regenerator flow resistance, thermal conductance losses, dead volume, surface area and heat transfer coefficient are analyzed. Regenerator cost and performance comparison data between the conventional widely used method of stacked screens and the new stacked laminate matrix regenerator is discussed. Also, a square stainless steel screen laminate was manufactured in a way which permits gas to flow along the screen wire instead of across it. (Author)

  4. Low cost and high performance screen laminate regenerator matrix

    Science.gov (United States)

    Bin-Nun, Uri; Manitakos, Dan

    2004-06-01

    A laminate screen matrix regenerator with 47 elements has been designed, analyzed, fabricated and tested. The laminate was fabricated from stainless steel screen sheets that were stacked on top of each other at certain angular orientation and then bonded at high temperature and pressure environment utilizing a sintering process. This laminate is a porous structure media with highly repeatable properties that can be controlled by varying mesh size, weave type, wire size and laminate sheet to sheet orientation. The flow direction in relation to the weave plan can be varied by cutting a cylindrical or rectangular laminate element along or across the weave. The regenerator flow resistance, thermal conductance losses, dead volume, surface area and heat transfer coefficient are analyzed. Regenerator cost and performance comparison data between the conventional widely used method of stacked screens and the new stacked laminate matrix regenerator is discussed. Also, a square stainless steel screen laminate was manufactured in a way which permits gas to flow along the screen wire instead of across it.

  5. 47 CFR 54.705 - Committees of the Administrator's Board of Directors.

    Science.gov (United States)

    2010-10-01

    ...-return carriers described in subpart K of this part by the High Cost and Low Income Division. The High...) The Administrator's Chief Executive Officer. (c) High Cost and Low Income Committee—(1) Committee functions. The High Cost and Low Income Committee shall oversee the administration of the high cost and...

  6. Predicting high-cost pediatric patients: derivation and validation of a population-based model.

    Science.gov (United States)

    Leininger, Lindsey J; Saloner, Brendan; Wherry, Laura R

    2015-08-01

    Health care administrators often lack feasible methods to prospectively identify new pediatric patients with high health care needs, precluding the ability to proactively target appropriate population health management programs to these children. To develop and validate a predictive model identifying high-cost pediatric patients using parent-reported health (PRH) measures that can be easily collected in clinical and administrative settings. Retrospective cohort study using 2-year panel data from the 2001 to 2011 rounds of the Medical Expenditure Panel Survey. A total of 24,163 children aged 5-17 with family incomes below 400% of the federal poverty line were included in this study. Predictive performance, including the c-statistic, sensitivity, specificity, and predictive values, of multivariate logistic regression models predicting top-decile health care expenditures over a 1-year period. Seven independent domains of PRH measures were tested for predictive capacity relative to basic sociodemographic information: the Children with Special Health Care Needs (CSHCN) Screener; subjectively rated health status; prior year health care utilization; behavioral problems; asthma diagnosis; access to health care; and parental health status and access to care. The CSHCN screener and prior year utilization domains exhibited the highest incremental predictive gains over the baseline model. A model including sociodemographic characteristics, the CSHCN screener, and prior year utilization had a c-statistic of 0.73 (95% confidence interval, 0.70-0.74), surpassing the commonly used threshold to establish sufficient predictive capacity (c-statistic>0.70). The proposed prediction tool, comprising a simple series of PRH measures, accurately stratifies pediatric populations by their risk of incurring high health care costs.

  7. Comparison of high-speed rail and maglev system costs

    Energy Technology Data Exchange (ETDEWEB)

    Rote, D.M.

    1998-07-01

    This paper compares the two modes of transportation, and notes important similarities and differences in the technologies and in how they can be implemented to their best advantage. Problems with making fair comparisons of the costs and benefits are discussed and cost breakdowns based on data reported in the literature are presented and discussed in detail. Cost data from proposed and actual construction projects around the world are summarized and discussed. Results from the National Maglev Initiative and the recently-published Commercial Feasibility Study are included in the discussion. Finally, estimates will be given of the expected cost differences between HSR and maglev systems implemented under simple and complex terrain conditions. The extent to which the added benefits of maglev technology offset the added costs is examined.

  8. Why projects often fail even with high cost contingencies

    Energy Technology Data Exchange (ETDEWEB)

    Kujawski, Edouard

    2002-02-28

    In this note we assume that the individual risks have been adequately quantified and the total project cost contingency adequately computed to ensure an agreed-to probability or confidence level that the total project cost estimate will not be exceeded. But even projects that implement such a process are likely to result in significant cost overruns and/or project failure if the project manager allocates the contingencies to the individual subsystems. The intuitive and mathematically valid solution is to maintain a project-wide contingency and to distribute it to the individual risks on an as-needed basis. Such an approach ensures cost-efficient risk management, and projects that implement it are more likely to succeed and to cost less. We illustrate these ideas using a simplified project with two independent risks. The formulation can readily be extended to multiple risks.

  9. Measurement of luminescence decays: High performance at low cost

    Science.gov (United States)

    Sulkes, Mark; Sulkes, Zoe

    2011-11-01

    The availability of inexpensive ultra bright LEDs spanning the visible and near-ultraviolet combined with the availability of inexpensive electronics equipment makes it possible to construct a high performance luminescence lifetime apparatus (˜5 ns instrumental response or better) at low cost. A central need for time domain measurement systems is the ability to obtain short (˜1 ns or less) excitation light pulses from the LEDs. It is possible to build the necessary LED driver using a simple avalanche transistor circuit. We describe first a circuit to test for small signal NPN transistors that can avalanche. We then describe a final optimized avalanche mode circuit that we developed on a prototyping board by measuring driven light pulse duration as a function of the circuit on the board and passive component values. We demonstrate that the combination of the LED pulser and a 1P28 photomultiplier tube used in decay waveform acquisition has a time response that allows for detection and lifetime determination of luminescence decays down to ˜5 ns. The time response and data quality afforded with the same components in time-correlated single photon counting are even better. For time-correlated single photon counting an even simpler NAND-gate based LED driver circuit is also applicable. We also demonstrate the possible utility of a simple frequency domain method for luminescence lifetime determinations.

  10. Care Coordination Challenges Among High-Needs, High-Costs Older Adults in a Medigap Plan

    Science.gov (United States)

    Wells, Timothy S.; Bhattarai, Gandhi R.; Hawkins, Kevin; Cheng, Yan; Ruiz, Joann; Barnowski, Cynthia A.; Spivack, Barney; Yeh, Charlotte S.

    2016-01-01

    Purpose of the Study: Many adults 65 years or older have high health care needs and costs. Here, we describe their care coordination challenges. Primary Practice Setting: Individuals with an AARP Medicare Supplement Insurance plan insured by UnitedHealthcare Insurance Company (for New York residents, UnitedHealthcare Insurance Company of New York). Methodology and Sample: The three groups included the highest needs, highest costs (the “highest group”), the high needs, high costs (the “high group”), and the “all other group.” Eligibility was determined by applying an internally developed algorithm based upon a number of criteria, including hierarchical condition category score, the Optum ImpactPro prospective risk score, as well as diagnoses of coronary artery disease, congestive heart failure, or diabetes. Results: The highest group comprised 2%, although consumed 12% of health care expenditures. The high group comprised 20% and consumed 46% of expenditures, whereas the all other group comprised 78% and consumed 42% of expenditures. On average, the highest group had $102,798 in yearly health care expenditures, compared with $34,610 and $7,634 for the high and all other groups, respectively. Fifty-seven percent of the highest group saw 16 or more different providers annually, compared with 21% and 2% of the high and all other groups, respectively. Finally, 28% of the highest group had prescriptions from at least seven different providers, compared with 20% and 5% of the high and all other groups, respectively. Implications for Case Management Practice: Individuals with high health care needs and costs have visits to numerous health care providers and receive multiple prescriptions for pharmacotherapy. As a result, these individuals can become overwhelmed trying to manage and coordinate their health care needs. Care coordination programs may help these individuals coordinate their care. PMID:27301064

  11. Manufacturing High-Quality Carbon Nanotubes at Lower Cost

    Science.gov (United States)

    Benavides, Jeanette M.; Lidecker, Henning

    2004-01-01

    A modified electric-arc welding process has been developed for manufacturing high-quality batches of carbon nanotubes at relatively low cost. Unlike in some other processes for making carbon nanotubes, metal catalysts are not used and, consequently, it is not necessary to perform extensive cleaning and purification. Also, unlike some other processes, this process is carried out at atmospheric pressure under a hood instead of in a closed, pressurized chamber; as a result, the present process can be implemented more easily. Although the present welding-based process includes an electric arc, it differs from a prior electric-arc nanotube-production process. The welding equipment used in this process includes an AC/DC welding power source with an integral helium-gas delivery system and circulating water for cooling an assembly that holds one of the welding electrodes (in this case, the anode). The cathode is a hollow carbon (optionally, graphite) rod having an outside diameter of 2 in. (approximately equal to 5.1 cm) and an inside diameter of 5/8 in. (approximately equal to 1.6 cm). The cathode is partly immersed in a water bath, such that it protrudes about 2 in. (about 5.1 cm) above the surface of the water. The bottom end of the cathode is held underwater by a clamp, to which is connected the grounding cable of the welding power source. The anode is a carbon rod 1/8 in. (approximately equal to 0.3 cm) in diameter. The assembly that holds the anode includes a thumbknob- driven mechanism for controlling the height of the anode. A small hood is placed over the anode to direct a flow of helium downward from the anode to the cathode during the welding process. A bell-shaped exhaust hood collects the helium and other gases from the process. During the process, as the anode is consumed, the height of the anode is adjusted to maintain an anode-to-cathode gap of 1 mm. The arc-welding process is continued until the upper end of the anode has been lowered to a specified height

  12. Medical costs associated with cardiovascular events among high-risk patients with hyperlipidemia

    Directory of Open Access Journals (Sweden)

    Bonafede MM

    2015-06-01

    Full Text Available Machaon M Bonafede,1 Barbara H Johnson,1 Akshara Richhariya,2 Shravanthi R Gandra2 1Outcomes Research, Truven Health Analytics, Cambridge, MA, USA; 2Global Health Economics, Amgen, Thousand Oaks, CA, USA Objectives: This study descriptively examined acute and longer term direct medical costs associated with a major cardiovascular (CV event among high-risk coronary heart disease risk-equivalent (CHD-RE patients. It also gives a firsthand look at fatal versus nonfatal CV events. Methods: The MarketScan® Commercial Claims and Encounters Database was used to identify adults with a CV event in 2006–2012 with hyperlipidemia or lipid-lowering therapy use in the 18 months prior to one of the following inpatient CV events: myocardial infarction, ischemic stroke, unstable angina, transient ischemic attack, percutaneous coronary intervention, or coronary artery bypass graft (CABG. Patients were required to have a preindex diagnosis of at least one of the following: peripheral arterial disease, abdominal aortic aneurysm, carotid artery disease, or diabetes. A subset analysis was conducted with patients with data linkable to the Social Security Administration Master Death File. Direct medical costs were reported for each quarter following a CV event, for up to 36 months after the first CV event. Results: In total, 38,609 CHD-RE patients were included, mean age 57 years, 31% female. CABG, myocardial infarction, and percutaneous coronary intervention were the most frequent and most expensive first CV events, accounting for >75% of all first CV events with mean first quarter costs ranging from $17,454 (nonfatal transient ischemic attack to $125,690 (fatal CABG. Overall, 15% of those with a first CV event went on to have a second event during the 36-month study period with mean first quarter nonfatal and fatal costs similar to first event levels. Third CV events were rare, happening in less than 3% of patients. Conclusion: CV events among CHD-RE patients were

  13. High School/Preschool Partnership Program: Administrative Guide [and] Curriculum Guide. Field Test Edition.

    Science.gov (United States)

    Pinellas County School Board, Clearwater, FL.

    An administrative and curriculum guide are presented for the High School/Preschool Partnership Program in which high school students gain experience with handicapped preschoolers in a mainstreamed setting. The program is intended to expand services to high schoolers (parenting skills and career skills) as well as preschoolers. The administrative…

  14. 48 CFR 9904.410 - Allocation of business unit general and administrative expenses to final cost objectives.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Allocation of business... Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST...

  15. High flight costs, but low dive costs, in auks support the biomechanical hypothesis for flightlessness in penguins.

    Science.gov (United States)

    Elliott, Kyle H; Ricklefs, Robert E; Gaston, Anthony J; Hatch, Scott A; Speakman, John R; Davoren, Gail K

    2013-06-01

    Flight is a key adaptive trait. Despite its advantages, flight has been lost in several groups of birds, notably among seabirds, where flightlessness has evolved independently in at least five lineages. One hypothesis for the loss of flight among seabirds is that animals moving between different media face tradeoffs between maximizing function in one medium relative to the other. In particular, biomechanical models of energy costs during flying and diving suggest that a wing designed for optimal diving performance should lead to enormous energy costs when flying in air. Costs of flying and diving have been measured in free-living animals that use their wings to fly or to propel their dives, but not both. Animals that both fly and dive might approach the functional boundary between flight and nonflight. We show that flight costs for thick-billed murres (Uria lomvia), which are wing-propelled divers, and pelagic cormorants (Phalacrocorax pelagicus) (foot-propelled divers), are the highest recorded for vertebrates. Dive costs are high for cormorants and low for murres, but the latter are still higher than for flightless wing-propelled diving birds (penguins). For murres, flight costs were higher than predicted from biomechanical modeling, and the oxygen consumption rate during dives decreased with depth at a faster rate than estimated biomechanical costs. These results strongly support the hypothesis that function constrains form in diving birds, and that optimizing wing shape and form for wing-propelled diving leads to such high flight costs that flying ceases to be an option in larger wing-propelled diving seabirds, including penguins.

  16. Cost-effectiveness of triple drug administration (TDA) with praziquantel, ivermectin and albendazole for the prevention of neglected tropical diseases in Nigeria.

    Science.gov (United States)

    Evans, D; McFarland, D; Adamani, W; Eigege, A; Miri, E; Schulz, J; Pede, E; Umbugadu, C; Ogbu-Pearse, P; Richards, F O

    2011-12-01

    Onchocerciasis, lymphatic filariasis (LF), schistosomiasis and soil transmitted, helminthiasis (STH) are all co-endemic in Nigeria. Annual mass drug administration (MDA) with ivermectin (for onchocerciasis), albendazole (for STH and with ivermectin for LF) and praziquantel (for schistosomiasis) is the WHO-recommended treatment strategy for preventive chemotherapy. Separate delivery rounds for distribution of these drugs have been the usual approach to MDA. All three drugs, however, have now been shown to be clinically and programmatically safe for co-administration with what has come to be known as triple drug administration (TDA). We examined the cost savings of converting from separate delivery rounds to TDA in two states in Nigeria. In 2008, eight local government areas received a single round of ivermectin with albendazole followed at least 1 week later by a single round of praziquantel to school-aged children. The following year, a single round was administered with TDA. The number of treated individuals was essentially unchanged during both years (1,301,864 in 2008 and 1,297,509 in 2009) and no change in adverse events was reported. The total programmatic costs for the MDA, not including drug and overhead costs, reduced by 41% from $123,624 to $72,870. Cost savings were limited in larger populations due to economies of scale. TDA is recommended for mature MDA.

  17. Life Cycle Cost Model for Very High Speed Integrated Circuits.

    Science.gov (United States)

    1984-09-01

    circuitry of the finished product level. ASD/ACCC has access to PRICE M on UNINET (30). 4. PRICE H (Programmed Review of Information for Costing and...AWAL/AAAS- 2) has successfully used PRICE H to analyze hardware acquisition costs. ASD/ACCC has access to PRICE H on UNINET ,-I" (13:1).• 5. PRICE L...ASD/ACCC has access to this model on UNINET (17:21). VHSIC Program Description As discussed earlier, LCC modeling includes all phases of a system’s

  18. Technical Evaluation Report 52: Audio/ Videoconferencing Packages: High cost

    Directory of Open Access Journals (Sweden)

    Urel Sawyers

    2005-11-01

    Full Text Available This report compares two integrated course delivery packages: Centra 6 and WebEx. Both applications feature asynchronous and synchronous audio communications for online education and training. They are relatively costly products, and provide useful comparisons with the two less expensive products to be evaluated in the following report #53. The criteria used in the current evaluation include capacity, interactivity features, integration with learning management systems, technical specifications, and cost. The report ends with a short analysis of the currently emerging audio-conferencing software, Google Talk.

  19. The high cost of free tuberculosis services: patient and household costs associated with tuberculosis care in Ebonyi State, Nigeria.

    Science.gov (United States)

    Ukwaja, Kingsley N; Alobu, Isaac; Lgwenyi, Chika; Hopewell, Philip C

    2013-01-01

    Poverty is both a cause and consequence of tuberculosis. The objective of this study is to quantify patient/household costs for an episode of tuberculosis (TB), its relationships with household impoverishment, and the strategies used to cope with the costs by TB patients in a resource-limited high TB/HIV setting. A cross-sectional study was conducted in three rural hospitals in southeast Nigeria. Consecutive adults with newly diagnosed pulmonary TB were interviewed to determine the costs each incurred in their care-seeking pathway using a standardised questionnaire. We defined direct costs as out-of-pocket payments, and indirect costs as lost income. Of 452 patients enrolled, majority were male 55% (249), and rural residents 79% (356), with a mean age of 34 (± 11.6) years. Median direct pre-diagnosis/diagnosis cost was $49 per patient. Median direct treatment cost was $36 per patient. Indirect pre-diagnostic and treatment costs were $416, or 79% of total patient costs, $528. The median total cost of TB care per household was $592; corresponding to 37% of median annual household income pre-TB. Most patients reported having to borrow money 212(47%), sell assets 42(9%), or both 144(32%) to cope with the cost of care. Following an episode of TB, household income reduced increasing the proportion of households classified as poor from 54% to 79%. Before TB illness, independent predictors of household poverty were; rural residence (adjusted odds ratio [aOR] 2.8), HIV-positive status (aOR 4.8), and care-seeking at a private facility (aOR 5.1). After TB care, independent determinants of household poverty were; younger age (≤ 35 years; aOR 2.4), male gender (aOR 2.1), and HIV-positive status (aOR 2.5). Patient and household costs for TB care are potentially catastrophic even where services are provided free-of-charge. There is an urgent need to implement strategies for TB care that are affordable for the poor.

  20. Cost Effective Growth of High Temperature Piezoelectrics for Adaptive Flow Control Actuators Project

    Data.gov (United States)

    National Aeronautics and Space Administration — TRS Technologies, Inc. in collaboration with The Pennsylvania State University propose to develop new families of high temperature piezoelectric materials for...

  1. The High Cost of Harsh Discipline and Its Disparate Impact

    Science.gov (United States)

    Rumberger, Russell W.; Losen, Daniel J.

    2016-01-01

    School suspension rates have been rising since the early 1970s, especially for children of color. One body of research has demonstrated that suspension from school is harmful to students, as it increases the risk of retention and school dropout. Another has demonstrated that school dropouts impose huge social costs on their states and localities,…

  2. Philosophy of design for low cost and high reliability

    DEFF Research Database (Denmark)

    Jørgensen, John Leif; Liebe, Carl Christian

    1996-01-01

    do extensive component testing and screening which addressed the issues of reliability, thermo-mechanical properties, and radiation sensitivity of the commercial IC's. The facility helped to control costs by generating early information on component survival in space. The development philosophy...... and system flexibility are addressed.KEY WORDS: Micro satellite, stellar compass, star tracker, attitude determination....

  3. Cost-Effectiveness Analysis in Practice: Interventions to Improve High School Completion

    Science.gov (United States)

    Hollands, Fiona; Bowden, A. Brooks; Belfield, Clive; Levin, Henry M.; Cheng, Henan; Shand, Robert; Pan, Yilin; Hanisch-Cerda, Barbara

    2014-01-01

    In this article, we perform cost-effectiveness analysis on interventions that improve the rate of high school completion. Using the What Works Clearinghouse to select effective interventions, we calculate cost-effectiveness ratios for five youth interventions. We document wide variation in cost-effectiveness ratios between programs and between…

  4. The variation of acute treatment costs of trauma in high-income countries

    Directory of Open Access Journals (Sweden)

    Willenberg Lynsey

    2012-08-01

    Full Text Available Abstract Background In order to assist health service planning, understanding factors that influence higher trauma treatment costs is essential. The majority of trauma costing research reports the cost of trauma from the perspective of the receiving hospital. There has been no comprehensive synthesis and little assessment of the drivers of cost variation, such as country, trauma, subgroups and methods. The aim of this review is to provide a synthesis of research reporting the trauma treatment costs and factors associated with higher treatment costs in high income countries. Methods A systematic search for articles relating to the cost of acute trauma care was performed and included studies reporting injury severity scores (ISS, per patient cost/charge estimates; and costing methods. Cost and charge values were indexed to 2011 cost equivalents and converted to US dollars using purchasing power parities. Results A total of twenty-seven studies were reviewed. Eighty-one percent of these studies were conducted in high income countries including USA, Australia, Europe and UK. Studies either reported a cost (74.1% or charge estimate (25.9% for the acute treatment of trauma. Across studies, the median per patient cost of acute trauma treatment was $22,448 (IQR: $11,819-$33,701. However, there was variability in costing methods used with 18% of studies providing comprehensive cost methods. Sixty-three percent of studies reported cost or charge items incorporated in their cost analysis and 52% reported items excluded in their analysis. In all publications reviewed, predictors of cost included Injury Severity Score (ISS, surgical intervention, hospital and intensive care, length of stay, polytrauma and age. Conclusion The acute treatment cost of trauma is higher than other disease groups. Research has been largely conducted in high income countries and variability exists in reporting costing methods as well as the actual costs. Patient populations studied

  5. Bottom-Up Cost Analysis of a High Concentration PV Module

    Energy Technology Data Exchange (ETDEWEB)

    Horowitz, Kelsey A. W.; Woodhouse, Michael; Lee, Hohyun; Smestad, Greg P.

    2016-03-31

    We present a bottom-up model of III-V multi-junction cells, as well as a high concentration PV (HCPV) module. We calculate $0.59/W(DC) manufacturing costs for our model HCPV module design with today's capabilities, and find that reducing cell costs and increasing module efficiency offer the most promising paths for future cost reductions. Cell costs could be significantly reduced via substrate reuse and improved manufacturing yields.

  6. Many Mobile Health Apps Target High-Need, High-Cost Populations, But Gaps Remain.

    Science.gov (United States)

    Singh, Karandeep; Drouin, Kaitlin; Newmark, Lisa P; Lee, JaeHo; Faxvaag, Arild; Rozenblum, Ronen; Pabo, Erika A; Landman, Adam; Klinger, Elissa; Bates, David W

    2016-12-01

    With rising smartphone ownership, mobile health applications (mHealth apps) have the potential to support high-need, high-cost populations in managing their health. While the number of available mHealth apps has grown substantially, no clear strategy has emerged on how providers should evaluate and recommend such apps to patients. Key stakeholders, including medical professional societies, insurers, and policy makers, have largely avoided formally recommending apps, which forces patients to obtain recommendations from other sources. To help stakeholders overcome barriers to reviewing and recommending apps, we evaluated 137 patient-facing mHealth apps-those intended for use by patients to manage their health-that were highly rated by consumers and recommended by experts and that targeted high-need, high-cost populations. We found that there is a wide variety of apps in the marketplace but that few apps address the needs of the patients who could benefit the most. We also found that consumers' ratings were poor indications of apps' clinical utility or usability and that most apps did not respond appropriately when a user entered potentially dangerous health information. Going forward, data privacy and security will continue to be major concerns in the dissemination of mHealth apps. Project HOPE—The People-to-People Health Foundation, Inc.

  7. 78 FR 48868 - Proposed Cercla Administrative Cost Recovery Settlement; MassDOT, MassDOT Route 1 Right-of-Way...

    Science.gov (United States)

    2013-08-12

    ... AGENCY Proposed Cercla Administrative Cost Recovery Settlement; MassDOT, MassDOT Route 1 Right-of-Way...), concerning the MassDOT Route 1 Right-of-Way Site in Chelsea, Massachusetts with the following Settling Party... should refer to: In re: MassDOT Route 1 Right-of- Way Site, U.S. EPA Docket No.01-2013-0031. FOR...

  8. Beyond Conferences: Attitudes of High School Administrators toward Parental Involvement in One Small Midwestern State

    Science.gov (United States)

    Lloyd-Smith, Laura; Baron, Mark

    2010-01-01

    The importance of parental involvement for students of all ages has been documented by researchers and acknowledged by practitioners. Although many earlier studies have contended that there is a positive association between parental involvement and school performance at the middle and high school levels, administrators in the field are aware that…

  9. The road to success - from high quality public services towards the high-quality public administration

    OpenAIRE

    Mitreva, Elizabeta; Taskov, Nako

    2013-01-01

    There is empirical evidence that various quality improvement programmes in public administration have increased users' satisfaction. Yet, at the same time, mass public surveys indicate a decrease in trust in national government, Parliament and the civil service. This indicates that there is no linear relationship between service quality and trust. The perception of quality come from very specific observations of public services whereas trust refers to the government machinery in general. ...

  10. 42 CFR 412.86 - Payment for extraordinarily high-cost day outliers.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Payment for extraordinarily high-cost day outliers... Outlier Cases, Special Treatment Payment for New Technology, and Payment Adjustment for Certain Replaced Devices Payment for Outlier Cases § 412.86 Payment for extraordinarily high-cost day outliers. For...

  11. Oregon's High School Dropouts: Examining the Economic and Social Costs. Research Brief

    Science.gov (United States)

    Foundation for Educational Choice, 2010

    2010-01-01

    The Foundation for Educational Choice recently commissioned a new study to examine the economic and social costs of Oregon's high school dropouts. Emily House, the study's author, analyzed how dropouts in the state dramatically impact state finances through reduced tax revenues, increased Medicaid costs, and high incarceration rates. House's study…

  12. Low Profile, High Impact: Four Case Studies of High School Department Chairs Whose Transactions "Transform" Teachers and Administrators.

    Science.gov (United States)

    Wettersten, Jill A.

    This paper explores the leadership strategies of four exemplary high school department chairs. It develops a model based on social-exchange theory to show how chairs, as middle managers, must satisfy the expectations of both teachers and administrators. Data were derived from a case study of department chairs identified as exemplary in four…

  13. Time-driven activity-based costing of low-dose-rate and high-dose-rate brachytherapy for low-risk prostate cancer.

    Science.gov (United States)

    Ilg, Annette M; Laviana, Aaron A; Kamrava, Mitchell; Veruttipong, Darlene; Steinberg, Michael; Park, Sang-June; Burke, Michael A; Niedzwiecki, Douglas; Kupelian, Patrick A; Saigal, Christopher

    Cost estimates through traditional hospital accounting systems are often arbitrary and ambiguous. We used time-driven activity-based costing (TDABC) to determine the true cost of low-dose-rate (LDR) and high-dose-rate (HDR) brachytherapy for prostate cancer and demonstrate opportunities for cost containment at an academic referral center. We implemented TDABC for patients treated with I-125, preplanned LDR and computed tomography based HDR brachytherapy with two implants from initial consultation through 12-month followup. We constructed detailed process maps for provision of both HDR and LDR. Personnel, space, equipment, and material costs of each step were identified and used to derive capacity cost rates, defined as price per minute. Each capacity cost rate was then multiplied by the relevant process time and products were summed to determine total cost of care. The calculated cost to deliver HDR was greater than LDR by $2,668.86 ($9,538 vs. $6,869). The first and second HDR treatment day cost $3,999.67 and $3,955.67, whereas LDR was delivered on one treatment day and cost $3,887.55. The greatest overall cost driver for both LDR and HDR was personnel at 65.6% ($4,506.82) and 67.0% ($6,387.27) of the total cost. After personnel costs, disposable materials contributed the second most for LDR ($1,920.66, 28.0%) and for HDR ($2,295.94, 24.0%). With TDABC, the true costs to deliver LDR and HDR from the health system perspective were derived. Analysis by physicians and hospital administrators regarding the cost of care afforded redesign opportunities including delivering HDR as one implant. Our work underscores the need to assess clinical outcomes to understand the true difference in value between these modalities. Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  14. Low Cost High Performance Nanostructured Spectrally Selective Coating

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Sungho [Univ. of California, San Diego, CA (United States)

    2017-04-05

    Sunlight absorbing coating is a key enabling technology to achieve high-temperature high-efficiency concentrating solar power operation. A high-performance solar absorbing material must simultaneously meet all the following three stringent requirements: high thermal efficiency (usually measured by figure of merit), high-temperature durability, and oxidation resistance. The objective of this research is to employ a highly scalable process to fabricate and coat black oxide nanoparticles onto solar absorber surface to achieve ultra-high thermal efficiency. Black oxide nanoparticles have been synthesized using a facile process and coated onto absorber metal surface. The material composition, size distribution and morphology of the nanoparticle are guided by numeric modeling. Optical and thermal properties have been both modeled and measured. High temperature durability has been achieved by using nanocomposites and high temperature annealing. Mechanical durability on thermal cycling have also been investigated and optimized. This technology is promising for commercial applications in next-generation high-temperature concentration solar power (CSP) plants.

  15. Cost evaluation of a DSN high level real-time language

    Science.gov (United States)

    Mckenzie, M.

    1977-01-01

    The hypothesis that the implementation of a DSN High Level Real Time Language will reduce real time software expenditures is explored. The High Level Real Time Language is found to be both affordable and cost-effective.

  16. Food Assistance: Financial Information on WIC Nutrition Services and Administrative Costs. United States General Accounting Office Report to Congressional Committees.

    Science.gov (United States)

    Robertson, Robert E.

    The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a federally funded nutrition assistance program administered by the Department of Agriculture's (USDA) Food and Nutrition Service (FNS). Responding to Congressional requests for information regarding program costs, this report provides information on: (1) funding…

  17. 77 FR 46433 - Proposed CERCLA Administrative Cost Recovery Settlements for the Buckbee-Mears Co. Superfund Site...

    Science.gov (United States)

    2012-08-03

    ...; request for public comment. SUMMARY: Under Section 122(h) of the Comprehensive Environmental Response... attributable to the costs of marketing and selling the Properties. Any proceeds from the Bank's foreclosure... proportion to the percentage that the following amounts represent in relation to the combined total of...

  18. The Impact of Patient Profiles and Procedures on Hospitalization Costs through Length of Stay in Community-Acquired Pneumonia Patients Based on a Japanese Administrative Database.

    Directory of Open Access Journals (Sweden)

    Hironori Uematsu

    Full Text Available Community-acquired pneumonia is a common cause of patient hospitalization, and its burden on health care systems is increasing in aging societies. In this study, we aimed to investigate the factors that affect hospitalization costs in community-acquired pneumonia patients while considering the intermediate influence of patient length of stay.Using a multi-institutional administrative claims database, we analyzed 30,041 patients hospitalized for community-acquired pneumonia who had been discharged between April 1, 2012 and September 30, 2013 from 289 acute care hospitals in Japan. Possible factors associated with hospitalization costs were investigated using structural equation modeling with length of stay as an intermediate variable. We calculated the direct, indirect (through length of stay, and total effects of the candidate factors on hospitalization costs in the model. Lastly, we calculated the ratio of indirect effects to direct effects for each factor.The structural equation model showed that higher disease severities (using A-DROP, Barthel Index, and Charlson Comorbidity Index scores, use of mechanical ventilation, and tube feeding were associated with higher hospitalization costs, regardless of the intermediate influence of length of stay. The severity factors were also associated with longer length of stay durations. The ratio of indirect effects to direct effects on total hospitalization costs showed that the former was greater than the latter in the factors, except in the use of mechanical ventilation.Our structural equation modeling analysis indicated that patient profiles and procedures impacted on hospitalization costs both directly and indirectly. Furthermore, the profiles were generally shown to have greater indirect effects (through length of stay on hospitalization costs than direct effects. These findings may be useful in supporting the more appropriate distribution of health care resources.

  19. Using administrative data to identify U.S. Army soldiers at high-risk of perpetrating minor violent crimes.

    Science.gov (United States)

    Rosellini, Anthony J; Monahan, John; Street, Amy E; Hill, Eric D; Petukhova, Maria; Reis, Ben Y; Sampson, Nancy A; Benedek, David M; Bliese, Paul; Stein, Murray B; Ursano, Robert J; Kessler, Ronald C

    2017-01-01

    Growing concerns exist about violent crimes perpetrated by U.S. military personnel. Although interventions exist to reduce violent crimes in high-risk populations, optimal implementation requires evidence-based targeting. The goal of the current study was to use machine learning methods (stepwise and penalized regression; random forests) to develop models to predict minor violent crime perpetration among U.S. Army soldiers. Predictors were abstracted from administrative data available for all 975,057 soldiers in the U.S. Army 2004-2009, among whom 25,966 men and 2728 women committed a first founded minor violent crime (simple assault, blackmail-extortion-intimidation, rioting, harassment). Temporally prior administrative records measuring socio-demographic, Army career, criminal justice, medical/pharmacy, and contextual variables were used to build separate male and female prediction models that were then tested in an independent 2011-2013 sample. Final model predictors included young age, low education, early career stage, prior crime involvement, and outpatient treatment for diverse emotional and substance use problems. Area under the receiver operating characteristic curve was 0.79 (for men and women) in the 2004-2009 training sample and 0.74-0.82 (men-women) in the 2011-2013 test sample. 30.5-28.9% (men-women) of all administratively-recorded crimes in 2004-2009 were committed by the 5% of soldiers having highest predicted risk, with similar proportions (28.5-29.0%) when the 2004-2009 coefficients were applied to the 2011-2013 test sample. These results suggest that it may be possible to target soldiers at high-risk of violence perpetration for preventive interventions, although final decisions about such interventions would require weighing predicted effectiveness against intervention costs and competing risks. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. DIPSY, a low-cost GPS application with high accuracy

    NARCIS (Netherlands)

    Heijden, W.F.M. van der

    1998-01-01

    To improve the control of unmanned aircraft flying out of visual range, the controller needs to be provided with realtime information about the position and behaviour of the drone during the flight. The position of the drone has to be presented with a relative high accuracy to obtain accurate flight

  1. Low cost, formable, high T(sub c) superconducting wire

    Science.gov (United States)

    Smialek, James L. (Inventor)

    1991-01-01

    A ceramic superconductivity part such as a wire is produced through the partial oxidation of a specially formulated copper alloy in the core. The alloys contain low level quantities of rare earth and alkaline earth dopant elements. Upon oxidation at high temperature, superconducting oxide phases are formed as a thin film.

  2. DIPSY, a low-cost GPS application with high accuracy

    NARCIS (Netherlands)

    Heijden, W.F.M. van der

    1999-01-01

    To improve the control of unmanned aircraft flying out of visual range, the controller needs to be provided with real-time information about the position and behaviour of the drone during the flight. The position of the drone has to be presented with a relative high accuracy to obtain accurate lligh

  3. Calculus in High School--At What Cost?

    Science.gov (United States)

    Sorge, D. H.; Wheatley, G. H.

    1977-01-01

    Evidence on the decline in preparation of entering calculus students and the relationship to high school preparation is presented, focusing on the trend toward the de-emphasis of trigonometry and analytic geometry in favor of calculus. Data on students' perception of the adequacy of their preparation are also presented. (Author/MN)

  4. Low cost routes to high purity silicon and derivatives thereof

    Energy Technology Data Exchange (ETDEWEB)

    Laine, Richard M; Krug, David James; Marchal, Julien Claudius; Mccolm, Andrew Stewart

    2013-07-02

    The present invention is directed to a method for providing an agricultural waste product having amorphous silica, carbon, and impurities; extracting from the agricultural waste product an amount of the impurities; changing the ratio of carbon to silica; and reducing the silica to a high purity silicon (e.g., to photovoltaic silicon).

  5. Low-Cost, High-Performance Analog Optical Links

    Science.gov (United States)

    2006-12-01

    5. BBR monolithic or integrated hybrid (long term solution, higher-risk, high-payoff implementation) Theoretical analysis of BBR We...85 BBR – integrated hybrid ................................................................................................... 90 BBR...for the DBR laser. ................................................ 12 Figure 11. Adiabatic chirp of the master-slave DBR laser (with left plot) and

  6. DIPSY, a low-cost GPS application with high accuracy

    NARCIS (Netherlands)

    Heijden, W.F.M. van der

    1999-01-01

    To improve the control of unmanned aircraft flying out of visual range, the controller needs to be provided with real-time information about the position and behaviour of the drone during the flight. The position of the drone has to be presented with a relative high accuracy to obtain accurate lligh

  7. DIPSY, a low-cost GPS application with high accuracy

    NARCIS (Netherlands)

    Heijden, W.F.M. van der

    1998-01-01

    To improve the control of unmanned aircraft flying out of visual range, the controller needs to be provided with realtime information about the position and behaviour of the drone during the flight. The position of the drone has to be presented with a relative high accuracy to obtain accurate flight

  8. How to Fight the High Cost of Curricular Glut

    Science.gov (United States)

    Bugeja, Michael

    2008-01-01

    Curriculum management is at the source of issues consuming academics, including high tuition, low adjunct pay, shared governance, graduate education, academic calendars, and budgetary models. The issue has the most impact at Ph.D.-granting public universities, but any institution can benefit from analyzing the source of poorly managed pedagogy,…

  9. DIPSY, a low-cost GPS application with high accuracy

    NARCIS (Netherlands)

    Heijden, W.F.M. van der

    1999-01-01

    To improve the control of unmanned aircraft flying out of visual range, the controller needs to be provided with real-time information about the position and behaviour of the drone during the flight. The position of the drone has to be presented with a relative high accuracy to obtain accurate

  10. Geocoding large population-level administrative datasets at highly resolved spatial scales

    OpenAIRE

    Edwards, Sharon E.; Strauss, Benjamin; Miranda, Marie Lynn

    2013-01-01

    Using geographic information systems to link administrative databases with demographic, social, and environmental data allows researchers to use spatial approaches to explore relationships between exposures and health. Traditionally, spatial analysis in public health has focused on the county, zip code, or tract level because of limitations to geocoding at highly resolved scales. Using 2005 birth and death data from North Carolina, we examine our ability to geocode population-level datasets a...

  11. High energy density capacitors for low cost applications

    Science.gov (United States)

    Iyore, Omokhodion David

    Polyvinylidene fluoride (PVDF) and its copolymers with trifluoroethylene, hexafluoropropylene and chlorotrifluoroethylene are the most widely investigated ferroelectric polymers, due to their relatively high electromechanical properties and potential to achieve high energy density. [Bauer, 2010; Zhou et al., 2009] The research community has focused primarily on melt pressed or extruded films of PVDF-based polymers to obtain the highest performance with energy density up to 25 Jcm-3. [Zhou et al., 2009] Solution processing offers an inexpensive, low temperature alternative, which is also easily integrated with flexible electronics. This dissertation focuses on the fabrication of solution-based polyvinylidene fluoride-hexafluoropropylene metal-insulator-metal capacitors on flexible substrates using a photolithographic process. Capacitors were optimized for maximum energy density, high dielectric strength and low leakage current density. It is demonstrated that with the right choice of solvent, electrodes, spin-casting and annealing conditions, high energy density thin film capacitors can be fabricated repeatably and reproducibly. The high electric field dielectric constants were measured and the reliabilities of the polymer capacitors were also evaluated via time-zero breakdown and time-dependent breakdown techniques. Chapter 1 develops the motivation for this work and provides a theoretical overview of dielectric materials, polarization, leakage current and dielectric breakdown. Chapter 2 is a literature review of polymer-based high energy density dielectrics and covers ferroelectric polymers, highlighting PVDF and some of its derivatives. Chapter 3 summarizes some preliminary experimental work and presents materials and electrical characterization that support the rationale for materials selection and process development. Chapter 4 discusses the fabrication of solution-processed PVDF-HFP and modification of its properties by photo-crosslinking. It is followed by a

  12. Low-Cost, High-Performance Combustion Chamber for LOX/CH4 Propulsion Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Ultramet will design and fabricate a lightweight, high temperature 5-lbf combustion chamber for use with cryogenic liquid oxygen/methane (LOX/CH4) propellant that...

  13. Costs of testing for ocular Chlamydia trachomatis infection compared to mass drug administration for trachoma in the Gambia: application of results from the PRET study.

    Directory of Open Access Journals (Sweden)

    Emma Harding-Esch

    2015-04-01

    Full Text Available Mass drug administration (MDA treatment of active trachoma with antibiotic is recommended to be initiated in any district where the prevalence of trachoma inflammation, follicular (TF is ≥ 10% in children aged 1-9 years, and then to continue for at least three annual rounds before resurvey. In The Gambia the PRET study found that discontinuing MDA based on testing a sample of children for ocular Chlamydia trachomatis(Ct infection after one MDA round had similar effects to continuing MDA for three rounds. Moreover, one round of MDA reduced disease below the 5% TF threshold. We compared the costs of examining a sample of children for TF, and of testing them for Ct, with those of MDA rounds.The implementation unit in PRET The Gambia was a census enumeration area (EA of 600-800 people. Personnel, fuel, equipment, consumables, data entry and supervision costs were collected for census and treatment of a sample of EAs and for the examination, sampling and testing for Ct infection of 100 individuals within them. Programme costs and resource savings from testing and treatment strategies were inferred for the 102 EAs in the study area, and compared.Census costs were $103.24 per EA plus initial costs of $108.79. MDA with donated azithromycin cost $227.23 per EA. The mean cost of examining and testing 100 children was $796.90 per EA, with Ct testing kits costing $4.80 per result. A strategy of testing each EA for infection is more expensive than two annual rounds of MDA unless the kit cost is less than $1.38 per result. However stopping or deciding not to initiate treatment in the study area based on testing a sample of EAs for Ct infection (or examining children in a sample of EAs creates savings relative to further unnecessary treatments.Resources may be saved by using tests for chlamydial infection or clinical examination to determine that initial or subsequent rounds of MDA for trachoma are unnecessary.

  14. Data of cost-optimality and technical solutions for high energy performance buildings in warm climate.

    Science.gov (United States)

    Zacà, Ilaria; D'Agostino, Delia; Maria Congedo, Paolo; Baglivo, Cristina

    2015-09-01

    The data reported in this article refers to input and output information related to the research articles entitled Assessment of cost-optimality and technical solutions in high performance multi-residential buildings in the Mediterranean area by Zacà et al. (Assessment of cost-optimality and technical solutions in high performance multi-residential buildings in the Mediterranean area, in press.) and related to the research article Cost-optimal analysis and technical comparison between standard and high efficient mono residential buildings in a warm climate by Baglivo et al. (Energy, 2015, 10.1016/j.energy.2015.02.062, in press).

  15. The Cost of Workplace Flexibility for High-Powered Professionals

    OpenAIRE

    Claudia D. Goldin; Katz, Lawrence F.

    2011-01-01

    The authors study the pecuniary penalties for family-related amenities in the workplace (e.g., job interruptions, short hours, part-time work, and flexibility during the workday), how women have responded to them, and how the penalties have changed over time. The pecuniary penalties to behaviors that are beneficial to family appear to have decreased in many professions. Self-employment has declined in many of the high-end professions (e.g., pharmacy, optometry, dentistry, law, medicine, and v...

  16. Bottom-Up Cost Analysis of a High Concentration PV Module; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    Horowitz, K.; Woodhouse, M.; Lee, H.; Smestad, G.

    2015-04-13

    We present a bottom-up model of III-V multi-junction cells, as well as a high concentration PV (HCPV) module. We calculate $0.65/Wp(DC) manufacturing costs for our model HCPV module design with today’s capabilities, and find that reducing cell costs and increasing module efficiency offer the promising pathways for future cost reductions. Cell costs could be significantly reduced via an increase in manufacturing scale, substrate reuse, and improved manufacturing yields. We also identify several other significant drivers of HCPV module costs, including the Fresnel lens primary optic, module housing, thermal management, and the receiver board. These costs could potentially be lowered by employing innovative module designs.

  17. Controlling Capital Costs in High Performance Office Buildings: A Review of Best Practices for Overcoming Cost Barriers

    Energy Technology Data Exchange (ETDEWEB)

    Pless, S.; Torcellini, P.

    2012-05-01

    This paper presents a set of 15 best practices for owners, designers, and construction teams of office buildings to reach high performance goals for energy efficiency, while maintaining a competitive budget. They are based on the recent experiences of the owner and design/build team for the Research Support Facility (RSF) on National Renewable Energy Facility's campus in Golden, CO, which show that achieving this outcome requires each key integrated team member to understand their opportunities to control capital costs.

  18. High performance/low cost accelerator control system

    Science.gov (United States)

    Magyary, S.; Glatz, J.; Lancaster, H.; Selph, F.; Fahmie, M.; Ritchie, A.; Timossi, C.; Hinkson, C.; Benjegerdes, R.

    1980-10-01

    Implementation of a high performance computer control system tailored to the requirements of the Super HILAC accelerator is described. This system uses a distributed structure with fiber optic data links; multiple CPUs operate in parallel at each node. A large number of the latest 16 bit microcomputer boards are used to get a significant processor bandwidth. Dynamically assigned and labeled knobs together with touch screens allow a flexible and efficient operator interface. An X-Y vector graphics system allows display and labeling of real time signals as well as general plotting functions. Both the accelerator parameters and the graphics system can be driven from BASIC interactive programs in addition to the precanned user routines.

  19. Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice.

    Science.gov (United States)

    Moreno, Mayara Franzoi; De Laquila, Rachel; Okuda, Marcos Hiromu; Lira, Fábio Santos; de Souza, Gabriel Inácio de Morais Honorato; de Souza, Cláudio Teodoro; Telles, Monica Marques; Ribeiro, Eliane Beraldi; do Nascimento, Claudia Maria Oller; Oyama, Lila Missae

    2014-01-01

    Obesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. The consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations. We examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG. We observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS. Our results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment.

  20. Cost optimization of load carrying thin-walled precast high performance concrete sandwich panels

    DEFF Research Database (Denmark)

    Hodicky, Kamil; Hansen, Sanne; Hulin, Thomas

    2015-01-01

    and HPCSP’s geometrical parameters as well as on material cost function in the HPCSP design. Cost functions are presented for High Performance Concrete (HPC), insulation layer, reinforcement and include labour-related costs. The present study reports the economic data corresponding to specific manufacturing......The paper describes a procedure to find the structurally and thermally efficient design of load-carrying thin-walled precast High Performance Concrete Sandwich Panels (HPCSP) with an optimal economical solution. A systematic optimization approach is based on the selection of material’s performances....... The solution of the optimization problem is performed in the computer package software Matlab® with SQPlab package and integrates the processes of HPCSP design, quantity take-off and cost estimation. The proposed optimization process outcomes in complex HPCSP design proposals to achieve minimum cost of HPCSP....

  1. Empathy costs: Negative emotional bias in high empathisers.

    Science.gov (United States)

    Chikovani, George; Babuadze, Lasha; Iashvili, Nino; Gvalia, Tamar; Surguladze, Simon

    2015-09-30

    Excessive empathy has been associated with compassion fatigue in health professionals and caregivers. We investigated an effect of empathy on emotion processing in 137 healthy individuals of both sexes. We tested a hypothesis that high empathy may underlie increased sensitivity to negative emotion recognition which may interact with gender. Facial emotion stimuli comprised happy, angry, fearful, and sad faces presented at different intensities (mild and prototypical) and different durations (500ms and 2000ms). The parameters of emotion processing were represented by discrimination accuracy, response bias and reaction time. We found that higher empathy was associated with better recognition of all emotions. We also demonstrated that higher empathy was associated with response bias towards sad and fearful faces. The reaction time analysis revealed that higher empathy in females was associated with faster (compared with males) recognition of mildly sad faces of brief duration. We conclude that although empathic abilities were providing for advantages in recognition of all facial emotional expressions, the bias towards emotional negativity may potentially carry a risk for empathic distress. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  2. Low-Cost, High-Performance Combustion Chamber

    Science.gov (United States)

    Fortini, Arthur J.

    2015-01-01

    Ultramet designed and fabricated a lightweight, high-temperature combustion chamber for use with cryogenic LOX/CH4 propellants that can deliver a specific impulse of approx.355 seconds. This increase over the current 320-second baseline of nitrogen tetroxide/monomethylhydrazine (NTO/MMH) will result in a propellant mass decrease of 55 lb for a typical lunar mission. The material system was based on Ultramet's proven oxide-iridium/rhenium architecture, which has been hot-fire tested with stoichiometric oxygen/hydrogen for hours. Instead of rhenium, however, the structural material was a niobium or tantalum alloy that has excellent yield strength at both ambient and elevated temperatures. Phase I demonstrated alloys with yield strength-to-weight ratios more than three times that of rhenium, which will significantly reduce chamber weight. The starting materials were also two orders of magnitude less expensive than rhenium and were less expensive than the C103 niobium alloy commonly used in low-performance engines. Phase II focused on the design, fabrication, and hot-fire testing of a 12-lbf thrust class chamber with LOX/CH4, and a 100-lbf chamber for LOX/CH4. A 5-lbf chamber for NTO/MMH also was designed and fabricated.

  3. Public high school teachers opinions on school administrators supervision duty in Turkey

    Directory of Open Access Journals (Sweden)

    Nurhayat Celebi

    2010-09-01

    Full Text Available Supervision that has been conducted by public high school administrators plays a major role in the effectiveness of a school.Lack of having well defined criteria is thought to be causing some major problems in the educational environment. Subjectivity,administrative policy constraints, lack of teacher motivation and lack of job satisfaction are only a few examples of those kindsof problems. The study, which is based on the scanning model and a descriptive research, was performed on 303 teachersworking in randomly chosen high schools in the Bakırköy district of İstanbul. The data collection instrument was developed bythe researcher. The confirmatory factor analysis test was used to determine whether the scale confirm to the factor structureor not. It was noticed that the factor structure could be explained with 5 factor sub-dimensions, and accordingly, the measuringscale, which had been originally prepared in 45 items, was modified and reduced to 32 items. As a result of factor analysis, thefactors were confirmed as follows; “the leadership, supervision techniques, effective supervision, efficacy of administration andteaching quality”. All these factors are explain about 48 % for total test variance. Cronbach alpha internal consistency factorwhich has been calculated according to the reliability analysis and it’s value was ,90. Factor loadings of sub- dimensions arebetween ,41 and ,81. In accordance with the results, training programs must be applied regularly to the administrators in orderto enable them to acquire more supervision attitude and to increase the efficiency and quality levels of the schools

  4. 78 FR 16808 - Connect America Fund; High-Cost Universal Service Support

    Science.gov (United States)

    2013-03-19

    ... establish any comparator groups.'' They argue that the benchmark ``formulas impose limitations on companies... modify the high cost loop support (HCLS) benchmarks. DATES: Effective March 19, 2013. FOR FURTHER... networks while requiring accountability from companies receiving support and ensuring fairness...

  5. [Evolution of reimbursement of high-cost anticancer drugs: Financial impact within a university hospital].

    Science.gov (United States)

    Baudouin, Amandine; Fargier, Emilie; Cerruti, Ariane; Dubromel, Amélie; Vantard, Nicolas; Ranchon, Florence; Schwiertz, Vérane; Salles, Gilles; Souquet, Pierre-Jean; Thomas, Luc; Bérard, Frédéric; Nancey, Stéphane; Freyer, Gilles; Trillet-Lenoir, Véronique; Rioufol, Catherine

    2017-06-01

    In the context of health expenses control, reimbursement of high-cost medicines with a 'minor' or 'nonexistent' improvement in actual health benefit evaluated by the Haute Autorité de santé is revised by the decree of March 24, 2016 related to the procedure and terms of registration of high-cost pharmaceutical drugs. This study aims to set up the economic impact of this measure. A six months retrospective study was conducted within a French university hospital from July 1, 2015 to December 31, 2015. For each injectable high-cost anticancer drug prescribed to a patient with cancer, the therapeutic indication, its status in relation to the marketing authorization and the associated improvement in actual health benefit were examined. The total costs of these treatments, the cost per type of indication and, in the case of marketing authorization indications, the cost per improvement in actual health benefit were evaluated considering that all drugs affected by the decree would be struck off. Over six months, 4416 high-cost injectable anticancer drugs were prescribed for a total cost of 4.2 million euros. The costs of drugs with a minor or nonexistent improvement in actual benefit and which comparator is not onerous amount 557,564 euros. The reform of modalities of inscription on the list of onerous drugs represents a significant additional cost for health institutions (1.1 million euros for our hospital) and raises the question of the accessibility to these treatments for cancer patients. Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

  6. Disruptive Models in Primary Care: Caring for High-Needs, High-Cost Populations.

    Science.gov (United States)

    Hochman, Michael; Asch, Steven M

    2017-04-01

    Starfield and colleagues have suggested four overarching attributes of good primary care: "first-contact access for each need; long-term person- (not disease) focused care; comprehensive care for most health needs; and coordinated care when it must be sought elsewhere." As this series on reinventing primary care highlights, there is a compelling need for new care delivery models that would advance these objectives. This need is particularly urgent for high-needs, high-cost (HNHC) populations. By definition, HNHC patients require extensive attention and consume a disproportionate share of resources, and as a result they strain traditional office-based primary care practices. In this essay, we offer a clinical vignette highlighting the challenges of caring for HNHC populations. We then describe two categories of primary care-based approaches for managing HNHC populations: complex case management, and specialized clinics focused on HNHC patients. Although complex case management programs can be incorporated into or superimposed on the traditional primary care system, such efforts often fail to engage primary care clinicians and HNHC patients, and proven benefits have been modest to date. In contrast, specialized clinics for HNHC populations are more disruptive, as care for HNHC patients must be transferred to a multidisciplinary team that can offer enhanced care coordination and other support. Such specialized clinics may produce more substantial benefits, though rigorous evaluation of these programs is needed. We conclude by suggesting policy reforms to improve care for HNHC populations.

  7. Does Co-Occurring Traumatic Brain Injury Affect VHA Outpatient Health Service Utilization and Associated Costs Among Veterans With Posttraumatic Stress Disorder? An Examination Based on VHA Administrative Data.

    Science.gov (United States)

    Kehle-Forbes, Shannon M; Campbell, Emily Hagel; Taylor, Brent C; Scholten, Joel; Sayer, Nina

    To examine whether a traumatic brain injury (TBI) diagnosis was associated with increased outpatient service utilization and associated costs among Iraq and Afghanistan (Operation Enduring Freedom [OEF]/Operation Iraqi Freedom [OIF]/Operation New Dawn [OND]) War veterans with posttraumatic stress disorder (PTSD) who used Veterans Health Affairs (VHA) care in a 1-year period. N/A. OEF/OIF/OND veterans with a diagnosis of PTSD and/or TBI who utilized VHA services during fiscal year 2012 (N = 164 644). Observational study using VHA administrative data. Outpatient VHA utilization (total and by category of care) and associated costs (total and by VA Health Economic Resource Center cost category). Veterans in the comorbid PTSD/TBI group had significantly more total outpatient appointment than veterans with PTSD but no TBI. This pattern held for all categories of care except orthopedics. The comorbid TBI/PTSD group ($5769) incurred greater median outpatient healthcare costs than the PTSD ($3168) or TBI-alone ($2815) group. Co-occurring TBI increases the already high level of healthcare utilization by veterans with PTSD, suggesting that OEF/OIF/OND veterans with comorbid PTSD/TBI have complex and wide-ranging healthcare needs.

  8. The Educational Context and Outcomes for High-School Students with Disabilities: The Perceptions of Administrators. Research Report.

    Science.gov (United States)

    Jones, Jennifer; Adams, Gary; Schumaker, Jean B.; Deshler, Donald D.; Davis, Betsy; Grossen, Bonnie; Bulgren, Janis A.; Marquis, Janet; Lenz, B. Keith

    The sixth in a series of studies investigating the educational context and outcomes for high school students with disabilities (SWDs), this study compared views of general education and special education administrators on the educational programs for SWDs and other at-risk students. Administrators in three high schools in urban areas, three in…

  9. Re-Engineering a High Performance Electrical Series Elastic Actuator for Low-Cost Industrial Applications

    Directory of Open Access Journals (Sweden)

    Kenan Isik

    2017-01-01

    Full Text Available Cost is an important consideration when transferring a technology from research to industrial and educational use. In this paper, we introduce the design of an industrial grade series elastic actuator (SEA performed via re-engineering a research grade version of it. Cost-constrained design requires careful consideration of the key performance parameters for an optimal performance-to-cost component selection. To optimize the performance of the new design, we started by matching the capabilities of a high-performance SEA while cutting down its production cost significantly. Our posit was that performing a re-engineering design process on an existing high-end device will significantly reduce the cost without compromising the performance drastically. As a case study of design for manufacturability, we selected the University of Texas Series Elastic Actuator (UT-SEA, a high-performance SEA, for its high power density, compact design, high efficiency and high speed properties. We partnered with an industrial corporation in China to research the best pricing options and to exploit the retail and production facilities provided by the Shenzhen region. We succeeded in producing a low-cost industrial grade actuator at one-third of the cost of the original device by re-engineering the UT-SEA with commercial off-the-shelf components and reducing the number of custom-made parts. Subsequently, we conducted performance tests to demonstrate that the re-engineered product achieves the same high-performance specifications found in the original device. With this paper, we aim to raise awareness in the robotics community on the possibility of low-cost realization of low-volume, high performance, industrial grade research and education hardware.

  10. Using the Black Scholes method for estimating high cost illness insurance premiums in Colombia

    Directory of Open Access Journals (Sweden)

    Liliana Chicaíza

    2009-04-01

    Full Text Available This article applied the Black-Scholes option valuation formula to calculating high-cost illness reinsurance premiums in the Colombian health system. The coverage pattern used in reinsuring high-cost illnesses was replicated by means of a European call option contract. The option’s relevant variables and parameters were adapted to an insurance market context. The premium estimated by the BlackScholes method fell within the range of premiums estimated by the actuarial method.

  11. Fundamental understanding and development of low-cost, high-efficiency silicon solar cells

    Energy Technology Data Exchange (ETDEWEB)

    ROHATGI,A.; NARASIMHA,S.; MOSCHER,J.; EBONG,A.; KAMRA,S.; KRYGOWSKI,T.; DOSHI,P.; RISTOW,A.; YELUNDUR,V.; RUBY,DOUGLAS S.

    2000-05-01

    The overall objectives of this program are (1) to develop rapid and low-cost processes for manufacturing that can improve yield, throughput, and performance of silicon photovoltaic devices, (2) to design and fabricate high-efficiency solar cells on promising low-cost materials, and (3) to improve the fundamental understanding of advanced photovoltaic devices. Several rapid and potentially low-cost technologies are described in this report that were developed and applied toward the fabrication of high-efficiency silicon solar cells.

  12. Considerations on a Cost Model for High-Field Dipole Arc Magnets for FCC

    CERN Document Server

    AUTHOR|(CDS)2078700; Durante, Maria; Lorin, Clement; Martinez, Teresa; Ruuskanen, Janne; Salmi, Tiina; Sorbi, Massimo; Tommasini, Davide; Toral, Fernando

    2017-01-01

    In the frame of the European Circular Collider (EuroCirCol), a conceptual design study for a post-Large Hadron Collider (LHC) research infrastructure based on an energy-frontier 100 TeV circular hadron collider [1]–[3], a cost model for the high-field dipole arc magnets is being developed. The aim of the cost model in the initial design phase is to provide the basis for sound strategic decisions towards cost effective designs, in particular: (A) the technological choice of superconducting material and its cost, (B) the target performance of Nb3Sn superconductor, (C) the choice of operating temperature (D) the relevant design margins and their importance for cost, (E) the nature and extent of grading, and (F) the aperture’s influence on cost. Within the EuroCirCol study three design options for the high field dipole arc magnets are under study: cos − θ [4], block [5], and common-coil [6]. Here, in the advanced design phase, a cost model helps to (1) identify the cost drivers and feed-back this informati...

  13. The burden of multiple myeloma: assessment on occurrence, outcomes and cost using a retrospective longitudinal study based on administrative claims database

    Directory of Open Access Journals (Sweden)

    Simona De Portu

    2011-12-01

    Full Text Available

    Objective: Multiple myeloma (MM is a malignancy of plasma cells that results in an overproduction of light and heavy chain monoclonal immunoglobulins. Multiple myeloma imposes a significant economic and humanistic burden on patients and society. The present study is aimed at assessing the burden of multiple myeloma in both epidemiologic and economic terms.

    Methods: A retrospective, naturalistic longitudinal study on the occurrence, outcome and cost of multiple myeloma using an administrative database, was performed. We selected residents of a North-eastern Region of Italy, who had their first hospital admission for multiple myeloma during the period 2001-2005. This group was followed up until 31-12-2006, death or transfers to other regional health services. Direct medical costs were quantified within the perspective of the Regional Health Service.

    Results: During the period 2001-2005, out of a population if 1.2 million inhabitants, we observed 517 incidents of patients diagnosed with MM (52% female. During the period of observation, 364 (70.4% subjects died. Total health care costs per patient over the maximum of follow-up were estimated to be 76,630 Euro for subjects younger than 70 years old and 22,892 Euro in the older group.

    Conclusions: Multiple myeloma imposes a significant epidemiological and economic burden on the healthcare system.

  14. Register-based indicators for potentially inappropriate medication in high-cost patients with excessive polypharmacy.

    Science.gov (United States)

    Saastamoinen, Leena K; Verho, Jouko

    2015-06-01

    Excessive polypharmacy is often associated with inappropriate drug use. Because drug expenditures are heavily skewed and a considerable share of patients in the top 5% of the cost distribution have excessive polypharmacy, the appropriateness of their drug use should be reviewed. The aim of this study was to review the quality of drug use in patients with extremely high costs and excessive polypharmacy and to compare them with all drug users. This is a nationwide register study. The subjects of this study were all drug users in Finland over 15 years of age, n = 3,303,813. The measures used were annual total costs, average costs, and number of patients. The background characteristics used included gender, age, morbidity, number of prescribers, active substances, and indicators of potentially inappropriate drug use, for example, Beers criteria. The patients with high costs and excessive polypharmacy accounted for 22% of the total pharmaceutical expenditures but only 3% of drug users. One-third of them were elderly, compared with 11.3% of all drug users (p polypharmacy patients used more potentially inappropriate (28.0% vs 19.9%, p polypharmacy with inappropriate medication use should be prevented using all the methods. The patients with excessive polypharmacy and high-drug costs provide a most interesting group for containing pharmaceutical costs via medication reviews. Copyright © 2015 John Wiley & Sons, Ltd.

  15. Geocoding large population-level administrative datasets at highly resolved spatial scales.

    Science.gov (United States)

    Edwards, Sharon E; Strauss, Benjamin; Miranda, Marie Lynn

    2014-08-01

    Using geographic information systems to link administrative databases with demographic, social, and environmental data allows researchers to use spatial approaches to explore relationships between exposures and health. Traditionally, spatial analysis in public health has focused on the county, zip code, or tract level because of limitations to geocoding at highly resolved scales. Using 2005 birth and death data from North Carolina, we examine our ability to geocode population-level datasets at three spatial resolutions - zip code, street, and parcel. We achieve high geocoding rates at all three resolutions, with statewide street geocoding rates of 88.0% for births and 93.2% for deaths. We observe differences in geocoding rates across demographics and health outcomes, with lower geocoding rates in disadvantaged populations and the most dramatic differences occurring across the urban-rural spectrum. Our results suggest highly resolved spatial data architectures for population-level datasets are viable through geocoding individual street addresses. We recommend routinely geocoding administrative datasets to the highest spatial resolution feasible, allowing public health researchers to choose the spatial resolution used in analysis based on an understanding of the spatial dimensions of the health outcomes and exposures being investigated. Such research, however, must acknowledge how disparate geocoding success across subpopulations may affect findings.

  16. Performance and Costs of Ductless Heat Pumps in Marine-Climate High-Performance Homes -- Habitat for Humanity The Woods

    Energy Technology Data Exchange (ETDEWEB)

    Lubliner, Michael [Building America Partnership for Improved Residential Construction, Olympia, WA (United States). Washington States Univ. Energy Program; Howard, Luke [Building America Partnership for Improved Residential Construction, Olympia, WA (United States). Washington States Univ. Energy Program; Hales, David [Building America Partnership for Improved Residential Construction, Olympia, WA (United States). Washington States Univ. Energy Program; Kunkle, Rick [Building America Partnership for Improved Residential Construction, Olympia, WA (United States). Washington States Univ. Energy Program; Gordon, Andy [Building America Partnership for Improved Residential Construction, Olympia, WA (United States). Washington States Univ. Energy Program; Spencer, Melinda [Building America Partnership for Improved Residential Construction, Olympia, WA (United States). Washington States Univ. Energy Program

    2016-02-18

    The Woods is a Habitat for Humanity (HFH) community of ENERGY STAR Homes Northwest (ESHNW)-certified homes located in the marine climate of Tacoma/Pierce County, Washington. This research report builds on an earlier preliminary draft 2014 BA report, and includes significant billing analysis and cost effectiveness research from a collaborative, ongoing Ductless Heat Pump (DHP)research effort for Tacoma Public Utilities (TPU) and Bonneville Power Administration (BPA). This report focuses on the results of field testing, modeling, and monitoring of ductless mini-split heat pump hybrid heating systems in seven homes built and first occupied at various times between September 2013 and October 2014. The report also provides WSU documentation of high-performance home observations, lessons learned, and stakeholder recommendations for builders of affordable high-performance housing such as HFH. Tacoma Public Utilities (TPU) and Bonneville Power Administration (BPA). This report focuses on the results of field testing, modeling, and monitoring of ductless mini-split heat pump hybrid heating systems in seven homes built and first occupied at various times between September 2013 and October 2014. The report also provides WSU documentation of high-performance home observations, lessons learned, and stakeholder recommendations for builders of affordable high-performance housing such as HFH.

  17. Automated packaging platform for low-cost high-performance optical components manufacturing

    Science.gov (United States)

    Ku, Robert T.

    2004-05-01

    Delivering high performance integrated optical components at low cost is critical to the continuing recovery and growth of the optical communications industry. In today's market, network equipment vendors need to provide their customers with new solutions that reduce operating expenses and enable new revenue generating IP services. They must depend on the availability of highly integrated optical modules exhibiting high performance, small package size, low power consumption, and most importantly, low cost. The cost of typical optical system hardware is dominated by linecards that are in turn cost-dominated by transmitters and receivers or transceivers and transponders. Cost effective packaging of optical components in these small size modules is becoming the biggest challenge to be addressed. For many traditional component suppliers in our industry, the combination of small size, high performance, and low cost appears to be in conflict and not feasible with conventional product design concepts and labor intensive manual assembly and test. With the advent of photonic integration, there are a variety of materials, optics, substrates, active/passive devices, and mechanical/RF piece parts to manage in manufacturing to achieve high performance at low cost. The use of automation has been demonstrated to surpass manual operation in cost (even with very low labor cost) as well as product uniformity and quality. In this paper, we will discuss the value of using an automated packaging platform.for the assembly and test of high performance active components, such as 2.5Gb/s and 10 Gb/s sources and receivers. Low cost, high performance manufacturing can best be achieved by leveraging a flexible packaging platform to address a multitude of laser and detector devices, integration of electronics and handle various package bodies and fiber configurations. This paper describes the operation and results of working robotic assemblers in the manufacture of a Laser Optical Subassembly

  18. Study on the fuel cycle cost of gas turbine high temperature reactor (GTHTR300). Contract research

    Energy Technology Data Exchange (ETDEWEB)

    Takei, Masanobu; Katanishi, Shoji; Nakata, Tetsuo; Kunitomi, Kazuhiko [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Oda, Takefumi; Izumiya, Toru [Nuclear Fuel Industries, Ltd., Tokyo (Japan)

    2002-11-01

    In the basic design of gas turbine high temperature reactor (GTHTR300), reduction of the fuel cycle cost has a large benefit of improving overall plant economy. Then, fuel cycle cost was evaluated for GTHTR300. First, of fuel fabrication for high-temperature gas cooled reactor, since there was no actual experience with a commercial scale, a preliminary design for a fuel fabrication plant with annual processing of 7.7 ton-U sufficient four GTHTR300 was performed, and fuel fabrication cost was evaluated. Second, fuel cycle cost was evaluated based on the equilibrium cycle of GTHTR300. The factors which were considered in this cost evaluation include uranium price, conversion, enrichment, fabrication, storage of spent fuel, reprocessing, and waste disposal. The fuel cycle cost of GTHTR300 was estimated at about 1.07 yen/kWh. If the back-end cost of reprocessing and waste disposal is included and assumed to be nearly equivalent to LWR, the fuel cycle cost of GTHTR300 was estimated to be about 1.31 yen/kWh. Furthermore, the effects on fuel fabrication cost by such of fuel specification parameters as enrichment, the number of fuel types, and the layer thickness were considered. Even if the enrichment varies from 10 to 20%, the number of fuel types change from 1 to 4, the 1st layer thickness of fuel changes by 30 {mu}m, or the 2nd layer to the 4th layer thickness of fuel changes by 10 {mu}m, the impact on fuel fabrication cost was evaluated to be negligible. (author)

  19. High Volume, Low-Cost Production Process for High-grade Silicon Carbide Optics Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The following proposal summarizes the process by which Trex will utilize out patented CVC (Chemical Vapor Composite) SiC process to fabricate near net shape...

  20. High Volume, Low-Cost Production Process for High-grade Silicon Carbide Optics Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The following proposal summarizes the process by which Trex Enterprises will utilize our patented CVC (Chemical Vapor Composite) SiC process towards the fabrication...

  1. Scalable Light Module for Low-Cost, High-Efficiency Light- Emitting Diode Luminaires

    Energy Technology Data Exchange (ETDEWEB)

    Tarsa, Eric [Cree, Inc., Goleta, CA (United States)

    2015-08-31

    During this two-year program Cree developed a scalable, modular optical architecture for low-cost, high-efficacy light emitting diode (LED) luminaires. Stated simply, the goal of this architecture was to efficiently and cost-effectively convey light from LEDs (point sources) to broad luminaire surfaces (area sources). By simultaneously developing warm-white LED components and low-cost, scalable optical elements, a high system optical efficiency resulted. To meet program goals, Cree evaluated novel approaches to improve LED component efficacy at high color quality while not sacrificing LED optical efficiency relative to conventional packages. Meanwhile, efficiently coupling light from LEDs into modular optical elements, followed by optimally distributing and extracting this light, were challenges that were addressed via novel optical design coupled with frequent experimental evaluations. Minimizing luminaire bill of materials and assembly costs were two guiding principles for all design work, in the effort to achieve luminaires with significantly lower normalized cost ($/klm) than existing LED fixtures. Chief project accomplishments included the achievement of >150 lm/W warm-white LEDs having primary optics compatible with low-cost modular optical elements. In addition, a prototype Light Module optical efficiency of over 90% was measured, demonstrating the potential of this scalable architecture for ultra-high-efficacy LED luminaires. Since the project ended, Cree has continued to evaluate optical element fabrication and assembly methods in an effort to rapidly transfer this scalable, cost-effective technology to Cree production development groups. The Light Module concept is likely to make a strong contribution to the development of new cost-effective, high-efficacy luminaries, thereby accelerating widespread adoption of energy-saving SSL in the U.S.

  2. The cost-effectiveness of directly observed highly-active antiretroviral therapy in the third trimester in HIV-infected pregnant women.

    Directory of Open Access Journals (Sweden)

    Caitlin J McCabe

    Full Text Available BACKGROUND: In HIV-infected pregnant women, viral suppression prevents mother-to-child HIV transmission. Directly observed highly-active antiretroviral therapy (HAART enhances virological suppression, and could prevent transmission. Our objective was to project the effectiveness and cost-effectiveness of directly observed administration of antiretroviral drugs in pregnancy. METHODS AND FINDINGS: A mathematical model was created to simulate cohorts of one million asymptomatic HIV-infected pregnant women on HAART, with women randomly assigned self-administered or directly observed antiretroviral therapy (DOT, or no HAART, in a series of Monte Carlo simulations. Our primary outcome was the quality-adjusted life expectancy in years (QALY of infants born to HIV-infected women, with the rates of Caesarean section and HIV-transmission after DOT use as intermediate outcomes. Both self-administered HAART and DOT were associated with decreased costs and increased life-expectancy relative to no HAART. The use of DOT was associated with a relative risk of HIV transmission of 0.39 relative to conventional HAART; was highly cost-effective in the cohort as a whole (cost-utility ratio $14,233 per QALY; and was cost-saving in women whose viral loads on self-administered HAART would have exceeded 1000 copies/ml. Results were stable in wide-ranging sensitivity analyses, with directly observed therapy cost-saving or highly cost-effective in almost all cases. CONCLUSIONS: Based on the best available data, programs that optimize adherence to HAART through direct observation in pregnancy have the potential to diminish mother-to-child HIV transmission in a highly cost-effective manner. Targeted use of DOT in pregnant women with high viral loads, who could otherwise receive self-administered HAART would be a cost-saving intervention. These projections should be tested with randomized clinical trials.

  3. High Cost/High Risk Components to Chalcogenide Molded Lens Model: Molding Preforms and Mold Technology

    Energy Technology Data Exchange (ETDEWEB)

    Bernacki, Bruce E.

    2012-10-05

    This brief report contains a critique of two key components of FiveFocal's cost model for glass compression molding of chalcogenide lenses for infrared applications. Molding preforms and mold technology have the greatest influence on the ultimate cost of the product and help determine the volumes needed to select glass molding over conventional single-point diamond turning or grinding and polishing. This brief report highlights key areas of both technologies with recommendations for further study.

  4. A low-cost hierarchical nanostructured beta-titanium alloy with high strength.

    Science.gov (United States)

    Devaraj, Arun; Joshi, Vineet V; Srivastava, Ankit; Manandhar, Sandeep; Moxson, Vladimir; Duz, Volodymyr A; Lavender, Curt

    2016-04-01

    Lightweighting of automobiles by use of novel low-cost, high strength-to-weight ratio structural materials can reduce the consumption of fossil fuels and in turn CO2 emission. Working towards this goal we achieved high strength in a low cost β-titanium alloy, Ti-1Al-8V-5Fe (Ti185), by hierarchical nanostructure consisting of homogenous distribution of micron-scale and nanoscale α-phase precipitates within the β-phase matrix. The sequence of phase transformation leading to this hierarchical nanostructure is explored using electron microscopy and atom probe tomography. Our results suggest that the high number density of nanoscale α-phase precipitates in the β-phase matrix is due to ω assisted nucleation of α resulting in high tensile strength, greater than any current commercial titanium alloy. Thus hierarchical nanostructured Ti185 serves as an excellent candidate for replacing costlier titanium alloys and other structural alloys for cost-effective lightweighting applications.

  5. Capital cost: low- and high-sulfur coal plants, 800 MWe

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    This Commercial Electric Power Cost Study for 800-MWe (Nominal) high- and low-sulfur coal plants consists of three volumes. The low-sulfur coal plant is described in Volumes I and II, while Volume III describes the high-sulfur coal plant. The design basis and cost estimate for the 801-MWe low sulfur coal plant is presented in Volume I, and the drawings, equimpment list, and site description are contained in Volume II. The design basis, drawings, and summary cost estimate for a 794-MWe high-sulfur coal plant are presented in Volume III. This information was developed by redesigning the low-sulfur sub-bituminous coal plant for burning high-sulfur bituminous coal. The reference design includes a lime flue-gas desulfurization system. These coal plants utilize a mechanical draft (wet) cooling tower system for condenser heat removal.

  6. Low-cost high-quality crystalline germanium based flexible devices

    KAUST Repository

    Nassar, Joanna M.

    2014-06-16

    High performance flexible electronics promise innovative future technology for various interactive applications for the pursuit of low-cost, light-weight, and multi-functional devices. Thus, here we show a complementary metal oxide semiconductor (CMOS) compatible fabrication of flexible metal-oxide-semiconductor capacitors (MOSCAPs) with high-κ/metal gate stack, using a physical vapor deposition (PVD) cost-effective technique to obtain a high-quality Ge channel. We report outstanding bending radius ~1.25 mm and semi-transparency of 30%.

  7. The high intensity solar cell: Key to low cost photovoltaic power

    Science.gov (United States)

    Sater, B. L.; Goradia, C.

    1975-01-01

    The design considerations and performance characteristics of the 'high intensity' (HI) solar cell are presented. A high intensity solar system was analyzed to determine its cost effectiveness and to assess the benefits of further improving HI cell efficiency. It is shown that residential sized systems can be produced at less than $1000/kW peak electric power. Due to their superior high intensity performance characteristics compared to the conventional and VMJ cells, HI cells and light concentrators may be the key to low cost photovoltaic power.

  8. Changes in choroidal thickness after systemic administration of high-dose corticosteroids: a pilot study.

    Science.gov (United States)

    Han, Jeong Mo; Hwang, Jeong-Min; Kim, Ji Soo; Park, Kyu Hyung; Woo, Se Joon

    2014-01-21

    To characterize the effects of corticosteroids on choroidal thickness, we measured the choroid thickness in patients treated systemically with a high-dose corticosteroid. A prospective, pilot study was conducted on 20 patients who required high-dose corticosteroid pulse therapy (>500 mg/d). Choroidal thickness was measured at baseline, 1 day, 1 week, and 1 month after corticosteroid administration. Blood pressure was measured four times a day for the first 5 days of steroid treatment. This study ultimately included 35 eyes from 18 patients. Each patient was treated with high-dose corticosteroid therapy at a concentration of 19.5 ± 4.1 mg per kg body weight for 5.2 ± 1.1 days. Mean subfoveal choroidal thickness at baseline was 259.8 μm (range, 86.4-394.7 μm). Choroidal thickness showed no significant change at 1 day, 1 week, or 1 month after corticosteroid administration (P = 0.197). Mean systolic blood pressure increased by 13 mmHg (P = 0.008), but diastolic pressure did not change (P = 0.117). One patient (5.6%) who had presented with pigment epithelial detatchment (PED) and thick choroid (381.1 μm) developed bilateral focal subretinal fluid during the study and showed central serous chorioretinopathy (CSC) with a 13.1% increase in subfoveal choroidal thickness. No consistent changes in choroidal thickness were observed after systemic high-dose corticosteroid treatment, but one patient with PED and thick choroid showed an increase in choroidal thickening as well as features of CSC. Thus, steroid-induced CSC may be an idiosyncratic response in selected vulnerable individuals rather than a dose-dependent effect.

  9. Low–Cost Bio-Based Carbon Fiber for High-Temperature Processing

    Energy Technology Data Exchange (ETDEWEB)

    Naskar, Amit K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Akato, Kokouvi M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Tran, Chau D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Paul, Ryan M. [GrafTech International Holdings, Inc., Brooklyn Heights, OH (United States); Dai, Xuliang [GrafTech International Holdings, Inc., Brooklyn Heights, OH (United States)

    2017-02-01

    GrafTech International Holdings Inc. (GTI), worked with Oak Ridge National Laboratory (ORNL) under CRADA No. NFE-15-05807 to develop lignin-based carbon fiber (LBCF) technology and to demonstrate LBCF performance in high-temperature products and applications. This work was unique and different from other reported LBCF work in that this study was application-focused and scalability-focused. Accordingly, the executed work was based on meeting criteria based on technology development, cost, and application suitability. The focus of this work was to demonstrate lab-scale LBCF from at least 4 different precursor feedstock sources that could meet the estimated production cost of $5.00/pound and have ash level of less than 500 ppm in the carbonized insulation-grade fiber. Accordingly, a preliminary cost model was developed based on publicly available information. The team demonstrated that 4 lignin samples met the cost criteria, as highlighted in Table 1. In addition, the ash level for the 4 carbonized lignin samples were below 500 ppm. Processing asreceived lignin to produce a high purity lignin fiber was a significant accomplishment in that most industrial lignin, prior to purification, had greater than 4X the ash level needed for this project, and prior to this work there was not a clear path of how to achieve the purity target. The lab scale development of LBCF was performed with a specific functional application in mind, specifically for high temperature rigid insulation. GTI is currently a consumer of foreignsourced pitch and rayon based carbon fibers for use in its high temperature insulation products, and the motivation was that LBCF had potential to decrease costs and increase product competitiveness in the marketplace through lowered raw material costs, lowered energy costs, and decreased environmental footprint. At the end of this project, the Technology Readiness Level (TRL) remained at 5 for LBCF in high temperature insulation.

  10. Low-Cost Bio-Based Carbon Fibers for High Temperature Processing

    Energy Technology Data Exchange (ETDEWEB)

    Paul, Ryan Michael [GrafTech International, Brooklyn Heights, OH (United States); Naskar, Amit [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-03

    GrafTech International Holdings Inc. (GTI), under Award No. DE-EE0005779, worked with Oak Ridge National Laboratory (ORNL) under CRADA No. NFE-15-05807 to develop lignin-based carbon fiber (LBCF) technology and to demonstrate LBCF performance in high-temperature products and applications. This work was unique and different from other reported LBCF work in that this study was application-focused and scalability-focused. Accordingly, the executed work was based on meeting criteria based on technology development, cost, and application suitability. High-temperature carbon fiber based insulation is used in energy intensive industries, such as metal heat treating and ceramic and semiconductor material production. Insulation plays a critical role in achieving high thermal and process efficiency, which is directly related to energy usage, cost, and product competitiveness. Current high temperature insulation is made with petroleum based carbon fibers, and one goal of this protect was to develop and demonstrate an alternative lignin (biomass) based carbon fiber that would achieve lower cost, CO2 emissions, and energy consumption and result in insulation that met or exceeded the thermal efficiency of current commercial insulation. In addition, other products were targeted to be evaluated with LBCF. As the project was designed to proceed in stages, the initial focus of this work was to demonstrate lab-scale LBCF from at least 4 different lignin precursor feedstock sources that could meet the estimated production cost of $5.00/pound and have ash level of less than 500 ppm in the carbonized insulation-grade fiber. Accordingly, a preliminary cost model was developed based on publicly available information. The team demonstrated that 4 lignin samples met the cost criteria. In addition, the ash level for the 4 carbonized lignin samples was below 500 ppm. Processing as-received lignin to produce a high purity lignin fiber was a significant accomplishment in that most industrial

  11. Sequential administration of the high affinity CXCR4 antagonist BKT140 promotes megakaryopoiesis and platelet production.

    Science.gov (United States)

    Abraham, Michal; Weiss, Ido D; Wald, Hanna; Wald, Ori; Nagler, Arnon; Beider, Katia; Eizenberg, Orly; Peled, Amnon

    2013-10-01

    Platelets are the terminal differentiation product of megakaryocytes (MKs). Cytokines, such as thrombopoietin (TPO), are known to influence different steps in MK development; however, the complex differentiation and platelet localization processes are not fully understood. MKs express the receptor CXCR4 and have been shown to migrate in response to CXCL12 and to increase their platelet production. In this study, we studied the role of CXCR4 in platelet production with the high affinity CXCR4 antagonist, BKT140. Single and sequential administration of BKT140 significantly increased the number of MKs and haematopoietic progenitors (HPCs) within the bone marrow (BM). Increased megakaryopoiesis was associated with increased platelet production. Single and sequential administration of BKT140 also increased the number of HPCs in the blood. In a model of 5-fluorouracil-induced thrombocytopenia, BKT140 significantly reduced the severity and duration of thrombocytopenia and cytopenia when administered before and after chemotherapy. Our results demonstrated that the CXCR4 antagonist, BKT140, mediated unique beneficial effects by stimulating megakaryopoiesis and platelet production. These results provide evidence for the possible therapeutic use of BKT140 for modulating platelet numbers in thrombocytopenic conditions. © 2013 John Wiley & Sons Ltd.

  12. Second Generation Novel High Temperature Commercial Receiver & Low Cost High Performance Mirror Collector for Parabolic Solar Trough

    Energy Technology Data Exchange (ETDEWEB)

    Stettenheim, Joel [Norwich Technologies, White River Junction, VT (United States)

    2016-02-29

    Norwich Technologies (NT) is developing a disruptively superior solar field for trough concentrating solar power (CSP). Troughs are the leading CSP technology (85% of installed capacity), being highly deployable and similar to photovoltaic (PV) systems for siting. NT has developed the SunTrap receiver, a disruptive alternative to vacuum-tube concentrating solar power (CSP) receivers, a market currently dominated by the Schott PTR-70. The SunTrap receiver will (1) operate at higher temperature (T) by using an insulated, recessed radiation-collection system to overcome the energy losses that plague vacuum-tube receivers at high T, (2) decrease acquisition costs via simpler structure, and (3) dramatically increase reliability by eliminating vacuum. It offers comparable optical efficiency with thermal loss reduction from ≥ 26% (at presently standard T) to ≥ 55% (at high T), lower acquisition costs, and near-zero O&M costs.

  13. Capital cost: high and low sulfur coal plants-1200 MWe. [For low sulfur coal

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    This Commercial Electric Power Cost Study for 1200 MWe (Nominal) high and low sulfur coal plants consists of three volumes. The high sulfur coal plant is described in Volumes I and II, while Volume III describes the low sulfur coal plant. The design basis and cost estimate for the 1232 MWe high sulfur coal plant is presented in Volume I, and the drawings, equipment list and site description are contained in Volume II. The reference design includes a lime flue gas desulfurization system. A regenerative sulfur dioxide removal system using magnesium oxide is also presented as an alternate in Section 7 V olume II. The design basis, drawings and summary cost estimate for a 1243 MWe low sulfur coal plant are presented in Volume III. This information was developed by redesigning the high sulfur coal plant for burning low sulfur sub-bituminous coal. These coal plants utilize a mechanical draft (wet) cooling tower system for condenser heat removal. Costs of alternate cooling systems are provided in Report No. 7 in this series of studies of costs of commercial electrical power plants.

  14. Assessing Risk in Costing High-energy Accelerators: from Existing Projects to the Future Linear Collider

    CERN Document Server

    Lebrun, Philippe

    2010-01-01

    High-energy accelerators are large projects funded by public money, developed over the years and constructed via major industrial contracts both in advanced technology and in more conventional domains such as civil engineering and infrastructure, for which they often constitute one-of markets. Assessing their cost, as well as the risk and uncertainty associated with this assessment is therefore an essential part of project preparation and a justified requirement by the funding agencies. Stemming from the experience with large circular colliders at CERN, LEP and LHC, as well as with the Main Injector, the Tevatron Collider Experiments and Accelerator Upgrades, and the NOvA Experiment at Fermilab, we discuss sources of cost variance and derive cost risk assessment methods applicable to the future linear collider, through its two technical approaches for ILC and CLIC. We also address disparities in cost risk assessment imposed by regional differences in regulations, procedures and practices.

  15. Cost-utility and cost-effectiveness analyses of a long-term, high-intensity exercise program compared with conventional physical therapy in patients with rheumatoid arthritis.

    NARCIS (Netherlands)

    Hout, W.B. van den; Jong, Z. de; Munneke, M.; Hazes, J.M.W.; Breedveld, F.C.; Vliet Vlieland, T.P.M.

    2005-01-01

    OBJECTIVE: To estimate the cost utility and cost effectiveness of long-term, high-intensity exercise classes compared with usual care in rheumatoid arthritis (RA) patients. METHODS: RA patients (n = 300) were randomly assigned to either exercise classes or UC; followup lasted for 2 years. Outcome me

  16. Cost-utility and cost-effectiveness analyses of a long-term, high-intensity exercise program compared with conventional physical therapy in patients with rheumatoid arthritis.

    NARCIS (Netherlands)

    Hout, W.B. van den; Jong, Z. de; Munneke, M.; Hazes, J.M.W.; Breedveld, F.C.; Vliet Vlieland, T.P.M.

    2005-01-01

    OBJECTIVE: To estimate the cost utility and cost effectiveness of long-term, high-intensity exercise classes compared with usual care in rheumatoid arthritis (RA) patients. METHODS: RA patients (n = 300) were randomly assigned to either exercise classes or UC; followup lasted for 2 years. Outcome me

  17. Pregnancy outcomes following the administration of high doses of dexamethasone in early pregnancy.

    Science.gov (United States)

    Namdar Ahmadabad, Hasan; Kayvan Jafari, Sabah; Nezafat Firizi, Maryam; Abbaspour, Ali Reza; Ghafoori Gharib, Fahime; Ghobadi, Yusef; Gholizadeh, Samira

    2016-03-01

    In the present study, we aimed to evaluate the effects of high doses of dexamethasone (DEX) in early pregnancy on pregnancy outcomes. Pregnant BALB/c mice were treated with high-dose DEX in the experimental group or saline in the control group on gestational days (GDs) 0.5 to 4.5. Pregnant mice were sacrificed on GDs 7.5, 13.5, or 18.5 and their peripheral blood, placentas, fetuses, and uterine tissue were collected. Decidual and placenta cell supernatants were examined to evaluate the effect of DEX on the proliferation of mononuclear cells, the quantity of uterine macrophages and uterine natural killer (uNK) cells, and levels of progesterone and 17β-estradiol, as determined by an 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide assay, immunohistochemistry, and enzyme-linked immunosorbent assay, respectively. We also were measured fetal and placental growth parameters on GD 18.5. We found that high doses of DEX were associated with an increased abortion rate, enhancement of the immunosuppressive effect of the decidua, alterations in placental growth parameters, decreased progesterone and 17β-estradiol levels, and a reduced frequency of macrophages and uNK cells. Our data suggest that the high-dose administration of DEX during early pregnancy negatively affected pregnancy outcomes.

  18. Construction of Meaning of the Undergraduate Course in Business Administration by High and Low Income Students

    Directory of Open Access Journals (Sweden)

    Marcelo de Rezende Pinto

    2015-01-01

    Full Text Available This paper reports the results of an empirical study undertaken with a sample of 368 undergraduate business administration students from five private universities in a large Brazilian city. The objective was to analyze the differences in perceptions of the course by students from high and low income backgrounds regarding the following issues: the cultural and symbolic elements involving higher education; the relevance of higher education in consumer priorities and the influence on consumption behavior of students; the appropriateness of the course to their reality; and the expected benefits of obtaining a degree. The data were analyzed using the Grade of Membership (GoM and t-test statistical techniques. The results, which were compared with the theoretical framework on consumption in a cultural and symbolic perspective, signaled there is a difference in meaning between the two groups of students.

  19. A low-cost hierarchical nanostructured beta-titanium alloy with high strength

    OpenAIRE

    Devaraj, Arun; Joshi, Vineet V.; Srivastava, Ankit; Manandhar, Sandeep; Moxson, Vladimir; Duz, Volodymyr A.; Lavender, Curt

    2016-01-01

    Lightweighting of automobiles by use of novel low-cost, high strength-to-weight ratio structural materials can reduce the consumption of fossil fuels and in turn CO2 emission. Working towards this goal we achieved high strength in a low cost β-titanium alloy, Ti–1Al–8V–5Fe (Ti185), by hierarchical nanostructure consisting of homogenous distribution of micron-scale and nanoscale α-phase precipitates within the β-phase matrix. The sequence of phase transformation leading to this hierarchical na...

  20. Comparing the assets of uninsured households to cost sharing under high-deductible health plans.

    Science.gov (United States)

    Jacobs, Paul D; Claxton, Gary

    2008-01-01

    Financial assets are relevant when one is assessing whether high-deductible plans, which require greater up-front cost sharing, are worthwhile for the uninsured. We show that uninsured households have less financial assets compared to the insured; at lower income levels, their net financial assets may even be negative. Although lower premiums may increase the ability of the uninsured to buy some coverage, high out-of-pocket liability may leave families exposed to costs that they cannot meet. Paying premiums for a policy that exposes the uninsured to unaffordable medical bills may be viewed as an uneconomical use of their limited assets.

  1. Who Are the High-Cost Users? A Method for Person-Centred Attribution of Health Care Spending.

    Directory of Open Access Journals (Sweden)

    Sara J T Guilcher

    Full Text Available To develop person-centered episodes of care (PCE for community-dwelling individuals in the top fifth percentile of Ontario health care expenditures in order to: (1 describe the main clinical groupings for spending; and (2 identify patterns of spending by health sector (e.g. acute care, home care, physician billings within and across PCE.Data were drawn from population-based administrative databases for all publicly funded health care in Ontario, Canada in 2010/11.This study is a retrospective cohort study.A total of 587,982 community-dwelling individuals were identified among those accounting for the top 5% of provincial health care expenditures between April 1, 2010 and March 31, 2011. PCE were defined as starting with an acute care admission and persisting through subsequent care settings and providers until individuals were without health system contact for 30 days. PCE were classified according to the clinical grouping for the initial admission. PCE and non-PCE costs were calculated and compared to provide a comprehensive measurement of total health system costs for the year.Among this community cohort, 697,059 PCE accounted for nearly 70% ($11,815.3 million (CAD of total annual publicly-funded expenditures on high-cost community-dwelling individuals. The most common clinical groupings to start a PCE were Acute Planned Surgical (35.2%, Acute Unplanned Medical (21.0% and Post-Admission Events (10.8%. Median PCE costs ranged from $3,865 (IQR = $1,712-$10,919 for Acute Planned Surgical to $20,687 ($12,207-$39,579 for Post-Admission Events. Inpatient acute ($8,194.5 million and inpatient rehabilitation ($434.6 million health sectors accounted for the largest proportions of allocated PCE spending over the year.Our study provides a novel methodological approach to categorize high-cost health system users into meaningful person-centered episodes. This approach helps to explain how costs are attributable within individuals across sectors and has

  2. A cost analysis of a pancreatic cancer screening protocol in high-risk populations.

    Science.gov (United States)

    Bruenderman, Elizabeth; Martin, Robert C G

    2015-09-01

    Pancreatic cancer is the 4th leading cause of cancer death in the United States. A screening protocol is needed to catch early-stage, resectable disease. This study suggests a protocol for high-risk individuals and assesses the cost in the context of the Affordable Care Act. Medicare and national average pricing were used for cost analysis of a protocol using magnetic resonance imaging/MRCP biannually in high-risk groups. Costs per year of life added" based on Medicare and national average costs, respectively, are as follows: $638.62 and $2,542.37 for Peutz-Jeghers syndrome, $945.33 and $3,763.44 for hereditary pancreatitis, $1,141.77 and $4,545.45 for familial pancreatic cancer and "p16-Leiden" mutations, and $356.42 and $1,418.92 for new-onset diabetes over age 50 with weight loss or smoking. A screening program using magnetic resonance imaging/MRCP is affordable in high-risk populations. The United States Preventive Services Task Force must re-evaluate its pancreatic cancer screening guidelines to make screening more cost-effective for the individual. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Refining Our Understanding of Value-Based Insurance Design and High Cost Sharing on Children.

    Science.gov (United States)

    Ellis, Randall P; Bachman, Sara S; Tan, Hui Ren

    2017-05-01

    There is significant concern about the financial burdens of new insurance plan designs on families, particularly families with children and youth with special health care needs (CYSHCN). With value-based insurance design (VBID) plans growing in popularity, this study examined the implications of selected VBID cost-sharing features on children. We studied children's health care spending patterns in 2 data sets that include high deductible and narrow network plans among others. Medical Expenditure Panel Survey data from 2007 to 2013 on 22 392 children were used to study out-of-pocket (OOP) costs according to CYSHCN, family income, and spending. MarketScan large employer insurance claims data from 2007 to 2014 (N = 4 263 452) were used to test for differences in mean total payments and OOP costs across various health plans. Across the data sets, we found that existing health plans place significant financial burdens on families, particularly lower income households and families with CYSHCN; individuals among the top 10% of OOP spending averaged more than $2000 per child. Although high deductible and consumer-driven plans impose substantial OOP costs on children, they do not significantly reduce spending, whereas health maintenance organizations that use network restrictions and tighter management do. Our results do not support the conclusion that high cost-sharing features that are common in VBID plans will significantly reduce health care spending on children. Copyright © 2017 by the American Academy of Pediatrics.

  4. Toward Low-Cost, High-Energy Density, and High-Power Density Lithium-Ion Batteries

    Science.gov (United States)

    Li, Jianlin; Du, Zhijia; Ruther, Rose E.; AN, Seong Jin; David, Lamuel Abraham; Hays, Kevin; Wood, Marissa; Phillip, Nathan D.; Sheng, Yangping; Mao, Chengyu; Kalnaus, Sergiy; Daniel, Claus; Wood, David L.

    2017-06-01

    Reducing cost and increasing energy density are two barriers for widespread application of lithium-ion batteries in electric vehicles. Although the cost of electric vehicle batteries has been reduced by 70% from 2008 to 2015, the current battery pack cost (268/kWh in 2015) is still >2 times what the USABC targets (125/kWh). Even though many advancements in cell chemistry have been realized since the lithium-ion battery was first commercialized in 1991, few major breakthroughs have occurred in the past decade. Therefore, future cost reduction will rely on cell manufacturing and broader market acceptance. This article discusses three major aspects for cost reduction: (1) quality control to minimize scrap rate in cell manufacturing; (2) novel electrode processing and engineering to reduce processing cost and increase energy density and throughputs; and (3) material development and optimization for lithium-ion batteries with high-energy density. Insights on increasing energy and power densities of lithium-ion batteries are also addressed.

  5. Toward Low-Cost, High-Energy Density, and High-Power Density Lithium-Ion Batteries

    Science.gov (United States)

    Li, Jianlin; Du, Zhijia; Ruther, Rose E.; AN, Seong Jin; David, Lamuel Abraham; Hays, Kevin; Wood, Marissa; Phillip, Nathan D.; Sheng, Yangping; Mao, Chengyu; Kalnaus, Sergiy; Daniel, Claus; Wood, David L.

    2017-09-01

    Reducing cost and increasing energy density are two barriers for widespread application of lithium-ion batteries in electric vehicles. Although the cost of electric vehicle batteries has been reduced by 70% from 2008 to 2015, the current battery pack cost (268/kWh in 2015) is still >2 times what the USABC targets (125/kWh). Even though many advancements in cell chemistry have been realized since the lithium-ion battery was first commercialized in 1991, few major breakthroughs have occurred in the past decade. Therefore, future cost reduction will rely on cell manufacturing and broader market acceptance. This article discusses three major aspects for cost reduction: (1) quality control to minimize scrap rate in cell manufacturing; (2) novel electrode processing and engineering to reduce processing cost and increase energy density and throughputs; and (3) material development and optimization for lithium-ion batteries with high-energy density. Insights on increasing energy and power densities of lithium-ion batteries are also addressed.

  6. High-Cost Patients Had Substantial Rates Of Leaving Medicare Advantage And Joining Traditional Medicare.

    Science.gov (United States)

    Rahman, Momotazur; Keohane, Laura; Trivedi, Amal N; Mor, Vincent

    2015-10-01

    Medicare Advantage payment regulations include risk-adjusted capitated reimbursement, which was implemented to discourage favorable risk selection and encourage the retention of members who incur high costs. However, the extent to which risk-adjusted capitation has succeeded is not clear, especially for members using high-cost services not previously considered in assessments of risk selection. We examined the rates at which participants who used three high-cost services switched between Medicare Advantage and traditional Medicare. We found that the switching rate from 2010 to 2011 away from Medicare Advantage and to traditional Medicare exceeded the switching rate in the opposite direction for participants who used long-term nursing home care (17 percent versus 3 percent), short-term nursing home care (9 percent versus 4 percent), and home health care (8 percent versus 3 percent). These results were magnified among people who were enrolled in both Medicare and Medicaid. Our findings raise questions about the role of Medicare Advantage plans in serving high-cost patients with complex care needs, who account for a disproportionately high amount of total health care spending.

  7. Modelling the health impact and cost-effectiveness of lymphatic filariasis eradication under varying levels of mass drug administration scale-up and geographic coverage.

    Science.gov (United States)

    Stone, Christopher M; Kastner, Randee; Steinmann, Peter; Chitnis, Nakul; Tanner, Marcel; Tediosi, Fabrizio

    2016-04-01

    A global programme to eliminate lymphatic filariasis (GPELF) is underway, yet two key programmatic features are currently still lacking: (1) the extension of efforts to all lymphatic filariasis (LF) endemic countries, and (2) the expansion of geographic coverage of mass drug administration (MDA) within countries. For varying levels of scale-up of MDA, we assessed the health benefits and the incremental cost-effectiveness ratios (ICERs) associated with LF eradication, projected the potential savings due to decreased morbidity management needs, and estimated potential household productivity gains as a result of reduced LF-related morbidity. We extended an LF transmission model to track hydrocele and lymphoedema incidence in order to obtain estimates of the disability adjusted life years (DALYs) averted due to scaling up MDA over a period of 50 years. We then estimated the ICERs and the cost-effectiveness acceptability curves associated with different rates of MDA scale-up. Health systems savings were estimated by considering the averted morbidity, treatment-seeking behaviour and morbidity management costs. Gains in worker productivity were estimated by multiplying estimated working days lost as a result of morbidity with country-specific per-worker agricultural wages. Our projections indicate that a massive scaling-up of MDA could lead to 4.38 million incremental DALYs averted over a 50-year time horizon compared to a scenario which mirrors current efforts against LF. In comparison to maintaining the current rate of progress against LF, massive scaling-up of MDA-pursuing LF eradication as soon as possible-was most likely to be cost-effective above a willingness to pay threshold of US$71.5/DALY averted. Intensified MDA scale-up was also associated with lower ICERs. Furthermore, this could result in health systems savings up to US$483 million. Extending coverage to all endemic areas could generate additional economic benefits through gains in worker productivity

  8. Sliver Solar Cells: High-Efficiency, Low-Cost PV Technology

    Directory of Open Access Journals (Sweden)

    Evan Franklin

    2007-01-01

    Full Text Available Sliver cells are thin, single-crystal silicon solar cells fabricated using standard fabrication technology. Sliver modules, composed of several thousand individual Sliver cells, can be efficient, low-cost, bifacial, transparent, flexible, shadow tolerant, and lightweight. Compared with current PV technology, mature Sliver technology will need 10% of the pure silicon and fewer than 5% of the wafer starts per MW of factory output. This paper deals with two distinct challenges related to Sliver cell and Sliver module production: providing a mature and robust Sliver cell fabrication method which produces a high yield of highly efficient Sliver cells, and which is suitable for transfer to industry; and, handling, electrically interconnecting, and encapsulating billions of sliver cells at low cost. Sliver cells with efficiencies of 20% have been fabricated at ANU using a reliable, optimised processing sequence, while low-cost encapsulation methods have been demonstrated using a submodule technique.

  9. Costs of high-field superconducting strands for particle accelerator magnets

    CERN Document Server

    Cooley, L D; Scanlan, R M; 10.1088/0953-2048/18/4/R01

    2005-01-01

    The costs of superconducting magnet strands are compared by calculating a 'production scaling factor' P that relates purchase data to the cost of raw materials. Using a consistent method, we normalize for different conductor geometries and strand diameters to arrive at cost indices in $ kg/sup -1/, $ m/sup -1/, and $ kA/sup -1/ m/sup -1/. Analyses of Nb47Ti conductors taken from the past 25 years of high-field magnet projects reveal that the price of raw materials and, to a lesser extent, finished strands, have tracked the price of niobium pentoxide. Performance gains during the 1980s produced $ kA /sup -1/ m/sup -1/ indices that fell with time ahead of strand cost in $ m/sup -1/, a situation that may reflect the present status of Nb /sub 3/Sn magnet conductors. Analyses of present materials show that P decreases systematically with billet mass. While production strands in 200-500 kg billets have costs ~3 times the cost of raw materials, the 20-50 kg billet size for internal-tin Nb/sub 3/Sn composites drives ...

  10. Individual variation in reproductive costs of reproduction: high-quality females always do better.

    Science.gov (United States)

    Hamel, Sandra; Côté, Steeve D; Gaillard, Jean-Michel; Festa-Bianchet, Marco

    2009-01-01

    1. Although life-history theory predicts substantial costs of reproduction, individuals often show positive correlations among life-history traits, rather than trade-offs. The apparent absence of reproductive costs may result from heterogeneity in individual quality. 2. Using detailed longitudinal data from three contrasted ungulate populations (mountain goats, Oreamnos americanus; bighorn sheep, Ovis canadensis; and roe deer, Capreolus capreolus), we assessed how individual quality affects the probability of detecting a cost of current reproduction on future reproduction for females. We used a composite measure of individual quality based on variations in longevity (all species), success in the last breeding opportunity before death (goats and sheep), adult mass (all species), and social rank (goats only). 3. In all species, high-quality females consistently had a higher probability of reproduction, irrespective of previous reproductive status. In mountain goats, we detected a cost of reproduction only after accounting for differences in individual quality. Only low-quality female goats were less likely to reproduce following years of breeding than of nonbreeding. Offspring survival was lower in bighorn ewes following years of successful breeding than after years when no lamb was produced, but only for low-quality females, suggesting that a cost of reproduction only occurred for low-quality females. 4. Because costs of reproduction differ among females, studies of life-history evolution must account for heterogeneity in individual quality.

  11. How do high cost-sharing policies for physician care affect inpatient care use and costs among people with chronic disease?

    Science.gov (United States)

    Xin, Haichang

    2015-01-01

    Rapidly rising health care costs continue to be a significant concern in the United States. High cost-sharing strategies thus have been widely used to address rising health care costs. Since high cost-sharing policies can reduce needed care as well as unneeded care use, it raises the concern whether these policies for physician care are a good strategy for controlling costs among chronically ill patients, especially whether utilization and costs in inpatient care will increase in response. This study examined whether high cost sharing in physician care affects inpatient care utilization and costs differently between individuals with and without chronic conditions. Findings from this study will contribute to the insurance benefit design that can control care utilization and save costs of chronically ill individuals. Prior studies suffered from gaps that limit both internal validity and external validity of their findings. This study has its unique contributions by filling these gaps jointly. The study used data from the 2007 Medical Expenditure Panel Survey, a nationally representative sample, with a cross-sectional study design. Instrumental variable technique was used to address the endogeneity between health care utilization and cost-sharing levels. We used negative binomial regression to analyze the count data and generalized linear models for costs data. To account for national survey sampling design, weight and variance were adjusted. The study compared the effects of high cost-sharing policies on inpatient care utilization and costs between individuals with and without chronic conditions to answer the research question. The final study sample consisted of 4523 individuals; among them, 752 had hospitalizations. The multivariate analysis demonstrated consistent patterns. Compared with low cost-sharing policies, high cost-sharing policies for physician care were not associated with a greater increase in inpatient care utilization (P = .86 for chronically ill

  12. Estimation of costs for control of Salmonella in high-risk feed materials and compound feed

    Directory of Open Access Journals (Sweden)

    Martin Wierup

    2014-06-01

    Full Text Available Introduction: Feed is a potential and major source for introducing Salmonella into the animal-derived food chain. This is given special attention in the European Union (EU efforts to minimize human food-borne Salmonella infections from animal-derived food. The objective of this study was to estimate the total extra cost for preventing Salmonella contamination of feed above those measures required to produce commercial feed according to EU regulation (EC No 183/2005. The study was carried out in Sweden, a country where Salmonella infections in food-producing animals from feed have largely been eliminated. Methods: On the initiative and leadership of the competent authority, the different steps of feed production associated with control of Salmonella contamination were identified. Representatives for the major feed producers operating in the Swedish market then independently estimated the annual mean costs during the years 2009 and 2010. The feed producers had no known incentives to underestimate the costs. Results and discussion: The total cost for achieving a Salmonella-safe compound feed, when such a control is established, was estimated at 1.8–2.3 € per tonne of feed. Of that cost, 25% relates to the prevention of Salmonella contaminated high-risk vegetable feed materials (mainly soybean meal and rapeseed meal from entering feed mills, and 75% for measures within the feed mills. Based on the feed formulations applied, those costs in relation to the farmers’ 2012 price for compound feed were almost equal for broilers and dairy cows (0.7%. Due to less use of protein concentrate to fatten pigs, the costs were lower (0.6%. These limited costs suggest that previous recommendations to enforce a Salmonella-negative policy for animal feed are realistic and economically feasible to prevent a dissemination of the pathogen to animal herds, their environment, and potentially to human food products.

  13. Cost-benefit analysis of esophageal cancer endoscopic screening in high-risk areas of China

    Institute of Scientific and Technical Information of China (English)

    Juan Yang; Wen-Qiang Wei; Jin Niu; Zhi-Cai Liu; Chun-Xia Yang; You-Lin Qiao

    2012-01-01

    AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer (EC) in high-risk areas of China.METHODS:Markov model-based analyses were conducted to compare the net present values (NPVs) and the benefit-cost ratios (BCRs) of 12 EC endoscopic screening strategies.Strategies varied according to the targeted screening age,screening frequencies,and follow-up intervals.Model parameters were collected from population-based studies in China,published literatures,and surveillance data.RESULTS:Compared with non-screening outcomes,all strategies with hypothetical 100 000 subjects saved life years.Among five dominant strategies determined by the incremental cost-effectiveness analysis,screening once at age 50 years incurred the lowest NPV (international dollar-I$55 million) and BCR (2.52).Screening six times between 40-70 years at a 5-year interval [i.e.,six times(40)f-strategy] yielded the highest NPV (I$99 million) and BCR (3.06).Compared with six times(40)fstrategy,screening thrice between 40-70 years at a 10-year interval resulted in relatively lower NPV,but the same BCR.CONCLUSION:EC endoscopic screening is cost-beneficial in high-risk areas of China.Policy-makers should consider the cost-benefit,population acceptance,and local economic status when choosing suitable screening strategies.

  14. VISIBLE COSTS AND HIDDEN COSTS IN THE BAKING INDUSTRY

    Directory of Open Access Journals (Sweden)

    Criveanu Maria

    2013-04-01

    Full Text Available Hidden costs are present in the activity of any company, hardly identified in the traditional administrative accounting. The high levels of the hidden costs and their unknown presence have serious consequences on the decisions made by the managers. This paper aims at presenting some aspects related to the hidden costs that occur in the activity of the companies in the baking industry and the possibilities to reduce their level.

  15. VISIBLE COSTS AND HIDDEN COSTS IN THE BAKING INDUSTRY

    OpenAIRE

    Criveanu Maria; Ţaicu Marian

    2013-01-01

    Hidden costs are present in the activity of any company, hardly identified in the traditional administrative accounting. The high levels of the hidden costs and their unknown presence have serious consequences on the decisions made by the managers. This paper aims at presenting some aspects related to the hidden costs that occur in the activity of the companies in the baking industry and the possibilities to reduce their level.

  16. Technology alternatives towards low-cost and high-speed interconnect manufacturing

    NARCIS (Netherlands)

    Roozeboom, F.; Kniknie, B.; Lankhorst, A.M.; Winands, G.; Poodt, P.; Dingemans, G.; Keuning, W.; Kessels, W.M.M.; Bullema, J.E.; Bressers, P.M.M.C.; Oosterhuis, G.; Mueller, M.; Huis in 't Veld, Bert

    2012-01-01

    In this work we will review our recent work on novel alternative and disruptive technology concepts with industrial potential for cost-effective and high-speed interconnect manufacturing, in particular on the creation (drilling and filling) of advanced interconnects like TSVs. These technologies are

  17. The Cost of Empathy: Parent-Adolescent Conflict Predicts Emotion Dysregulation for Highly Empathic Youth

    Science.gov (United States)

    Van Lissa, Caspar J.; Hawk, Skyler T.; Koot, Hans M.; Branje, Susan; Meeus, Wim H. J.

    2017-01-01

    Empathy plays a key role in maintaining close relationships and promoting prosocial conflict resolution. However, research has not addressed the potential emotional cost of adolescents' high empathy, particularly when relationships are characterized by more frequent conflict. The present 6-year longitudinal study (N = 467) investigated whether…

  18. To Your Health: NLM update transcript - High costs of health care

    Science.gov (United States)

    ... https://medlineplus.gov/podcast/transcript022717.html To Your Health: NLM update Transcript High costs of health care : 02/27/2017 To use the sharing ... is what's new this week in To Your Health - a consumer health oriented podcast from NLM - that ...

  19. Technology alternatives towards low-cost and high-speed interconnect manufacturing

    NARCIS (Netherlands)

    Roozeboom, F.; Kniknie, B.; Lankhorst, A.M.; Winands, G.; Poodt, P.; Dingemans, G.; Keuning, W.; Kessels, W.M.M.; Bullema, J.E.; Bressers, P.M.M.C.; Oosterhuis, G.; Mueller, M.; Huis in 't Veld, A.J.

    2012-01-01

    In this work we will review our recent work on novel alternative and disruptive technology concepts with industrial potential for cost-effective and high-speed interconnect manufacturing, in particular on the creation (drilling and filling) of advanced interconnects like TSVs. These technologies are

  20. Evaluation of risk of nephrotoxicity with high dose, extended-interval colistin administration

    Directory of Open Access Journals (Sweden)

    Arun Dewan

    2014-01-01

    Full Text Available Aim: The aim was to evaluate the risk of nephrotoxicity with high-dose, extended-interval regimen of colistin administration in critical ill patients. Materials and Methods: This prospective study was conducted on patients suffering from sepsis due to Gram-negative infection susceptible only to colistin. The dosing schedule for colistin was 9 million units stat followed by 4.5 million units at 12 hourly interval (adjusted as per body weight and renal functions. The serum creatinine and creatinine clearance were estimated at the start of therapy and daily during therapy. Results: Thirty-one patients suffering ventilator associated pneumonia (61.29%, blood stream infections (29.03% and urinary tract infections (9.67% due to Gram-negative multiple drug resistance organisms were assessed. Most commonly isolated organism were Acinetobacter baumannii (54.83%, Klebsiella pneumonia (16.12% and Pseudomonas (29.03%. Five patients (16.12% developed acute kidney injury within 4-5 days of start of therapy and returned to baseline after 6 days with no patient requiring renal replacement therapy or discontinuation of colistin. Conclusion: Our study showed that high-dose, extended-interval colistin can be given to critically ill patients without any significant risk of nephrotoxicity.

  1. Cost-Effectiveness of Radiation and Chemotherapy for High-Risk Low-Grade Glioma.

    Science.gov (United States)

    Qian, Yushen; Maruyama, Satoshi; Kim, Haju; Pollom, Erqi L; Kumar, Kiran A; Chin, Alexander L; Harris, Jeremy P; Chang, Daniel T; Pitt, Allison; Bendavid, Eran; Owens, Douglas K; Durkee, Ben Y; Soltys, Scott G

    2017-06-28

    The addition of PCV (procarbazine, lomustine, vincristine) chemotherapy to radiotherapy (RT) for patients with high-risk (≥ 40 years old or sub-totally resected) low-grade glioma (LGG) results in an absolute median survival benefit of over 5 years. We evaluated the cost-effectiveness of this treatment strategy. A decision tree with an integrated three-state Markov model was created to follow patients with high risk LGG after surgery treated with RT vs. RT+PCV. Patients existed in one of 3 health states: stable, progressive, and dead. Survival and freedom from progression were modeled to reflect the results of RTOG 9802 using time-dependent transition probabilities. Health utility values and costs of care were derived from the literature and national registry databases. Analysis was conducted from the healthcare perspective. Deterministic and probabilistic sensitivity analysis explored uncertainty in model parameters. Modeled outcomes demonstrated agreement with clinical data in expected benefit of addition of PCV to RT. The addition of PCV to RT yielded an incremental benefit of 4.77 quality-adjusted life-years (QALYs) (9.94 for RT+PCV vs. 5.17 for RT alone) at an incremental cost of $48,635 ($188,234 for RT+PCV vs. $139,598 for RT alone), resulting in an incremental cost-effectiveness ratio of $10,186 per QALY gained. Probabilistic sensitivity analysis demonstrates that within modeled distributions of parameters, RT+PCV has 99.96% probability of being cost-effectiveness at a willingness-to-pay threshold of $100,000 per QALY. The addition of PCV to RT is a cost-effective treatment strategy for patients with high-risk LGG.

  2. High-school seniors' college enrollment goals: Costs and benefits of ambitious expectations.

    Science.gov (United States)

    Villarreal, Brandilynn J; Heckhausen, Jutta; Lessard, Jared; Greenberger, Ellen; Chen, Chuansheng

    2015-12-01

    High school students with high long-term educational expectations attain higher levels of education than those with lower expectations. Less studied is the role of students' short-term college enrollment expectations for the year after high school graduation. The purpose of the current study was to examine the costs and benefits of ambitious short-term expectations and the impact of falling short of these expectations on mental health, motivation, and educational outcomes. Over 1000 youth with expectations to attend college were surveyed during their senior year of high school, one year later, and four years later. Participants who did not achieve their short-term expectations had lower educational attainment four years later but were not less satisfied with their educational progress. The negative consequences of falling short of one's expectations were restricted to individuals with less ambitious short-term expectations. Thus, the benefits of ambitious short-term expectations for youth may outweigh the costs.

  3. WAHRSIS: A Low-cost, High-resolution Whole Sky Imager With Near-Infrared Capabilities

    CERN Document Server

    Dev, Soumyabrata; Lee, Yee Hui; Winkler, Stefan

    2016-01-01

    Cloud imaging using ground-based whole sky imagers is essential for a fine-grained understanding of the effects of cloud formations, which can be useful in many applications. Some such imagers are available commercially, but their cost is relatively high, and their flexibility is limited. Therefore, we built a new daytime Whole Sky Imager (WSI) called Wide Angle High-Resolution Sky Imaging System. The strengths of our new design are its simplicity, low manufacturing cost and high resolution. Our imager captures the entire hemisphere in a single high-resolution picture via a digital camera using a fish-eye lens. The camera was modified to capture light across the visible as well as the near-infrared spectral ranges. This paper describes the design of the device as well as the geometric and radiometric calibration of the imaging system.

  4. Availability and cost estimate of a high naphthene, modified aviation turbine fuel

    Science.gov (United States)

    Prok, George M.

    1988-01-01

    Information from an Air Force study was used to determine the potential availability and cost of a modified conventional fuel with a naphthene content which could have a thermal stability near that of JP-7 for high-speed civil transports. Results showed sufficient capacity for a fuel made of a blend of 50 percent naphthenic straight run kerosene and 50 percent hydrocracked product, assuming a near-term requirement of 210,000 BBL per day. Fuel cost would be as low as 62.5 to 64.5 cents per gallon, assuming 20 dollars per barrel for crude.

  5. Cost allocation model for distribution networks considering high penetration of distributed energy resources

    DEFF Research Database (Denmark)

    Soares, Tiago; Pereira, Fábio; Morais, Hugo;

    2015-01-01

    , losses, and congestion costs) is proposed comprising the use of a large set of DER, namely distributed generation (DG), demand response (DR) of direct load control type, energy storage systems (ESS), and electric vehicles with capability of discharging energy to the network, which is known as vehicle......The high penetration of distributed energy resources (DER) in distribution networks and the competitive environment of electricity markets impose the use of new approaches in several domains. The network cost allocation, traditionally used in transmission networks, should be adapted and used...

  6. Highly Conformal Ni Micromesh as a Current Collecting Front Electrode for Reduced Cost Si Solar Cell.

    Science.gov (United States)

    Gupta, Nikita; Rao, K D Mallikharjuna; Gupta, Ritu; Krebs, Frederik C; Kulkarni, Giridhar U

    2017-02-17

    Despite relatively high manufacturing cost, crystalline-Si solar cell continues to hold promising future due to its high energy conversion efficiency and long life. As regards cost, one pertinent issue is the top electrode metallization of textured cell surface, which typically involves screen printing of silver paste. The associated disadvantages call for alternative methods that can lower the cost without compromising the solar cell efficiency. In the present work, a highly interconnected one dimensional (1D) metal wire network has been employed as front electrode on conventional Si wafers. Here for the first time, we report an innovative solution based crackle templating method for conformal metal wire network patterning over large textured surfaces. Laser beam induced current mapping showed uniform photocurrent collection by the electrodes without any shadow losses. With electroless deposition of Ni wire network on corrugated solar cell, a short circuit current of 33.28 mA/cm2 was obtained in comparison to 20.53 mA/cm2 without the network electrode. On comparing the efficiency with the conventional cells with screen printed electrodes, a 20% increment in efficiency has been observed. Importantly, the estimated manufacturing cost is three orders lower.

  7. Evidence against the energetic cost hypothesis for the short introns in highly expressed genes

    Directory of Open Access Journals (Sweden)

    Niu Deng-Ke

    2008-05-01

    Full Text Available Abstract Background In animals, the moss Physcomitrella patens and the pollen of Arabidopsis thaliana, highly expressed genes have shorter introns than weakly expressed genes. A popular explanation for this is selection for transcription efficiency, which includes two sub-hypotheses: to minimize the energetic cost or to minimize the time cost. Results In an individual human, different organs may differ up to hundreds of times in cell number (for example, a liver versus a hypothalamus. Considered at the individual level, a gene specifically expressed in a large organ is actually transcribed tens or hundreds of times more than a gene with a similar expression level (a measure of mRNA abundance per cell specifically expressed in a small organ. According to the energetic cost hypothesis, the former should have shorter introns than the latter. However, in humans and mice we have not found significant differences in intron length between large-tissue/organ-specific genes and small-tissue/organ-specific genes with similar expression levels. Qualitative estimation shows that the deleterious effect (that is, the energetic burden of long introns in highly expressed genes is too negligible to be efficiently selected against in mammals. Conclusion The short introns in highly expressed genes should not be attributed to energy constraint. We evaluated evidence for the time cost hypothesis and other alternatives.

  8. A low-cost, high-resolution, video-rate imaging optical radar

    Energy Technology Data Exchange (ETDEWEB)

    Sackos, J.T.; Nellums, R.O.; Lebien, S.M.; Diegert, C.F. [Sandia National Labs., Albuquerque, NM (United States); Grantham, J.W.; Monson, T. [Air Force Research Lab., Eglin AFB, FL (United States)

    1998-04-01

    Sandia National Laboratories has developed a unique type of portable low-cost range imaging optical radar (laser radar or LADAR). This innovative sensor is comprised of an active floodlight scene illuminator and an image intensified CCD camera receiver. It is a solid-state device (no moving parts) that offers significant size, performance, reliability, and simplicity advantages over other types of 3-D imaging sensors. This unique flash LADAR is based on low cost, commercially available hardware, and is well suited for many government and commercial uses. This paper presents an update of Sandia`s development of the Scannerless Range Imager technology and applications, and discusses the progress that has been made in evolving the sensor into a compact, low, cost, high-resolution, video rate Laser Dynamic Range Imager.

  9. Avionics and Power Management for Low-Cost High-Altitude Balloon Science Platforms

    Science.gov (United States)

    Chin, Jeffrey; Roberts, Anthony; McNatt, Jeremiah

    2016-01-01

    High-altitude balloons (HABs) have become popular as educational and scientific platforms for planetary research. This document outlines key components for missions where low cost and rapid development are desired. As an alternative to ground-based vacuum and thermal testing, these systems can be flight tested at comparable costs. Communication, solar, space, and atmospheric sensing experiments often require environments where ground level testing can be challenging or impossible in certain cases. When performing HAB research the ability to monitor the status of the platform and gather data is key for both scientific and recoverability aspects of the mission. A few turnkey platform solutions are outlined that leverage rapidly evolving open-source engineering ecosystems. Rather than building custom components from scratch, these recommendations attempt to maximize simplicity and cost of HAB platforms to make launches more accessible to everyone.

  10. High flexibility and low cost digital implementation for modern PWM strategies

    DEFF Research Database (Denmark)

    Mathe, Laszlo; Sera, Dezso; Kerekes, Tamas

    2011-01-01

    In this paper a new low cost technique for PWM strategy implementation is presented. The proposed technique does not require dedicated hardware PWM units, thus offering higher flexibility of use. Furthermore, the aforementioned method eases the digital implementation of modern modulation methods ...... with hardware PWM unit. The experimental results show that this new technique is suitable to replace traditional implementation methods with minimum computational overhead, with the benefit of high flexibility, lower cost and faster code development.......In this paper a new low cost technique for PWM strategy implementation is presented. The proposed technique does not require dedicated hardware PWM units, thus offering higher flexibility of use. Furthermore, the aforementioned method eases the digital implementation of modern modulation methods...

  11. National Board Certification: Setting High Standards for Teaching, Learning, and Schools--An Administrator's Perspective.

    Science.gov (United States)

    Shakowski, Nancy J.

    1999-01-01

    Presents one administrator's perspective on the importance of the National Board for Professional Teaching Standards (NBPTS), describing the history of NBPTS certification in Colorado, discussing her experiences as a school administrator supporting teachers through NBPTS certification, examining the NBPTS's five core propositions, describing the…

  12. Perceptions of High School Administrators on Junior Reserve Officer Training Corps in Secondary Schools

    Science.gov (United States)

    Minkin, Amy J.

    2014-01-01

    The purpose of this qualitative study was to investigate and discover the beliefs and perceptions of secondary school administrators regarding the impact of Junior Reserve Officer Training Corps on student discipline and attendance in the secondary school setting. A qualitative, phenomenological research study investigated what administrators know…

  13. [Predicting individual risk of high healthcare cost to identify complex chronic patients].

    Science.gov (United States)

    Coderch, Jordi; Sánchez-Pérez, Inma; Ibern, Pere; Carreras, Marc; Pérez-Berruezo, Xavier; Inoriza, José M

    2014-01-01

    To develop a predictive model for the risk of high consumption of healthcare resources, and assess the ability of the model to identify complex chronic patients. A cross-sectional study was performed within a healthcare management organization by using individual data from 2 consecutive years (88,795 people). The dependent variable consisted of healthcare costs above the 95th percentile (P95), including all services provided by the organization and pharmaceutical consumption outside of the institution. The predictive variables were age, sex, morbidity-based on clinical risk groups (CRG)-and selected data from previous utilization (use of hospitalization, use of high-cost drugs in ambulatory care, pharmaceutical expenditure). A univariate descriptive analysis was performed. We constructed a logistic regression model with a 95% confidence level and analyzed sensitivity, specificity, positive predictive values (PPV), and the area under the ROC curve (AUC). Individuals incurring costs >P95 accumulated 44% of total healthcare costs and were concentrated in ACRG3 (aggregated CRG level 3) categories related to multiple chronic diseases. All variables were statistically significant except for sex. The model had a sensitivity of 48.4% (CI: 46.9%-49.8%), specificity of 97.2% (CI: 97.0%-97.3%), PPV of 46.5% (CI: 45.0%-47.9%), and an AUC of 0.897 (CI: 0.892 to 0.902). High consumption of healthcare resources is associated with complex chronic morbidity. A model based on age, morbidity, and prior utilization is able to predict high-cost risk and identify a target population requiring proactive care. Copyright © 2013 SESPAS. Published by Elsevier Espana. All rights reserved.

  14. The high intensity solar cell - Key to low cost photovoltaic power

    Science.gov (United States)

    Sater, B. L.; Goradia, C.

    1975-01-01

    This paper discusses the problems associated with conventional solar cells at high intensities and presents the design considerations and performance characteristics of the 'high intensity' (HI) solar cell which appears to eliminate the major problems. Test data obtained at greater than 250 AM1 suns gave a peak output power density of 2 W per sq cm at an efficiency exceeding 6% with an unoptimized cell operating at over 100 C. It appears that operation at 1000 AM1 suns at efficiencies greater than 10% is possible. At 1000 AM1 suns and 10% efficiency, the HI cell manufacturing cost is estimated to be $0.25/watt, with multi-megawatt annual production capability already existing within the industrial sector. A high intensity solar system was also analyzed to determine its cost effectiveness and to assess the benefits of further improving HI cell efficiency.

  15. Low Cost Al-Si Casting Alloy As In-Situ Composite for High Temperature Applications

    Science.gov (United States)

    Lee, Jonathan A.

    2000-01-01

    A new aluminum-silicon (Al-Si) alloy has been successfully developed at NASA- Marshall Space Flight Center (MSFC) that has significant improvement in tensile and fatigue strength at elevated temperatures (500 F-700 F). The alloy offers a number of benefits such as light weight, high hardness, low thermal expansion and high surface wear resistance. In hypereutectic form, this alloy is considered as an in-situ Al-Si composite with tensile strength of about 90% higher than the auto industry 390 alloy at 600 F. This composite is very economically produced by using either conventional permanent steel molds or die casting. The projected material cost is less than $0.90 per pound, and automotive components such as pistons can be cast for high production rate using conventional casting techniques with a low and fully accounted cost. Key Words: Metal matrix composites, In-situ composite, aluminum-silicon alloy, hypereutectic alloy, permanent mold casting, die casting.

  16. 75 FR 25113 - High-Cost Universal Service Support, Federal-State Joint Board on Universal Service, Lifeline and...

    Science.gov (United States)

    2010-05-07

    ... those of rural carriers, PRTC's embedded costs are actually too low to make it eligible for support... carriers. PRTC argues that the Commission must adopt its proposed embedded cost-based mechanism because: (1... comparable service; they ``include low-income consumers and those in rural, insular and high cost...

  17. High plasma concentration of beta-D-glucan after administration of sizofiran for cervical cancer

    Directory of Open Access Journals (Sweden)

    Hirokazu Tokuyasu

    2010-09-01

    Full Text Available Hirokazu Tokuyasu1, Kenichi Takeda1, Yuji Kawasaki1, Yasuto Sakaguchi2, Noritaka Isowa2, Eiji Shimizu3, Yasuto Ueda31Divisions of Respiratory Medicine, 2Thoracic Surgery, Matsue Red Cross Hospital, 200 Horomachi, Matsue, Shimane; 3Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, JapanAbstract: A 69-year-old woman with a history of cervical cancer was admitted to our hospital for further investigation of abnormal shadows on her chest roentgenogram. Histologic examination of transbronchial lung biopsy specimens revealed epithelioid cell granuloma, and Mycobacterium intracellulare was detected in the bronchial lavage fluid. The plasma level of (1→3-beta-D-glucan was very high, and this elevated level was attributed to administration of sizofiran for treatment of cervical cancer 18 years previously. Therefore, in patients with cervical cancer, it is important to confirm whether or not sizofiran has been administered before measuring (1→3-beta-D-glucan levels.Keywords: (1→3-beta-D-glucan, cervical cancer, Mycobacterium intracellulare, sizofiran

  18. R&D ADMINISTRATION IN THE HIGH TECHNOLOGY INDUSTRY: HOW TO MANAGE A PARADOX

    Directory of Open Access Journals (Sweden)

    Nobuiuki Costa Ito

    2010-10-01

    Full Text Available The competitive environment of the knowledge age is getting more complex, dynamic, and fast-moving each day. The high tech industry is intensively tied to its effects and demands for innovation, so the field of Research and Development must act strategically, generating innovations and granting success and sustainability to the business. However, there is a paradox in R&D which may lay traps and obstacles disguised by the busy day-to-day activity of the organization. The purpose of this paper is to point out directions that managers may take to cope with these contradictions in R&D administration. The R&D paradox is rooted in the conflict between exploitation, achieved by continual improvement through incremental innovation, and by exploration, which seeks new opportunities in the creation of new technologies through disruptive innovations. These two sides of the paradox demand different, and sometimes even divergent, organizations. Top management leadership is crucial for the acceptance and balancing of the contradictions created by this paradox, and can align exploitation/exploration through distributive and integrative decisions and transform companies into truly ambidextrous organizations.    Key-words:  Research & Development. Innovation. Paradox. Ambidextrous organizations. Strategy. 

  19. Cost-effective optoacoustic system based on the combination of high-power diode lasers

    Science.gov (United States)

    Sánchez, Miguel; Rodríguez, Sergio; Gawali, Sandeep B.; Leggio, Luca; Gallego, Daniel C.; Lamela, Horacio

    2017-03-01

    One of the main issues of the advances in optoacoustic (OA) applications is to reduce the high costs and the big sizes of solid state lasers. High-power diode lasers (HPDLs) have been demonstrated to be a valid alternative reducing enormously the expenses, besides other advantages such as smaller sizes and higher modulation frequencies. However, in some cases it is possible to furtherly reduce their costs. We present a cost-effective OA system based on the combination of several 905-nm HPDLs with direct coupling into a fiber bundle. These HPDLs have an internal pulse driver, based on an n-channel Mosfet and two charging capacitors, which needs an external Mosfet driver circuit and a voltage supply in order to improve the optical pulse shape and energy. We compare the performances and the prices of this OA system with another similar HPDL-based OA system built with commercial elements. Results indicate good OA signal generation ( 15.6 mVpp) with pulse energy of 12.3 μJ and, especially, a cost reduction by a factor of 15 if compared to the other HPDL-based system.

  20. Do "premium" joint implants add value?: analysis of high cost joint implants in a community registry.

    Science.gov (United States)

    Gioe, Terence J; Sharma, Amit; Tatman, Penny; Mehle, Susan

    2011-01-01

    Numerous joint implant options of varying cost are available to the surgeon, but it is unclear whether more costly implants add value in terms of function or longevity. We evaluated registry survival of higher-cost "premium" knee and hip components compared to lower-priced standard components. Premium TKA components were defined as mobile-bearing designs, high-flexion designs, oxidized-zirconium designs, those including moderately crosslinked polyethylene inserts, or some combination. Premium THAs included ceramic-on-ceramic, metal-on-metal, and ceramic-on-highly crosslinked polyethylene designs. We compared 3462 standard TKAs to 2806 premium TKAs and 868 standard THAs to 1311 premium THAs using standard statistical methods. The cost of the premium implants was on average approximately $1000 higher than the standard implants. There was no difference in the cumulative revision rate at 7-8 years between premium and standard TKAs or THAs. In this time frame, premium implants did not demonstrate better survival than standard implants. Revision indications for TKA did not differ, and infection and instability remained contributors. Longer followup is necessary to demonstrate whether premium implants add value in younger patient groups. Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

  1. Cost-Effectiveness of Highly Active Antiretroviral Therapy in South Africa.

    Directory of Open Access Journals (Sweden)

    2005-12-01

    Full Text Available BACKGROUND: Little information exists on the impact of highly active antiretroviral therapy (HAART on health-care provision in South Africa despite increasing scale-up of access to HAART and gradual reduction in HAART prices. METHODS AND FINDINGS: Use and cost of services for 265 HIV-infected adults without AIDS (World Health Organization [WHO] stage 1, 2, or 3 and 27 with AIDS (WHO stage 4 receiving HAART between 1995 and 2000 in Cape Town were compared with HIV-infected controls matched for baseline WHO stage, CD4 count, age, and socioeconomic status, who did not receive antiretroviral therapy (ART; No-ART group. Costs of service provision (January 2004 prices, US$1 = 7.6 Rand included local unit costs, and two scenarios for HAART prices for WHO recommended first-line regimens: scenario 1 used current South African public-sector ART drug prices of $730 per patient-year (PPY, whereas scenario 2 was based on the anticipated public-sector price for locally manufactured drug of $181 PPY. All analyses are presented in terms of patients without AIDS and patients with AIDS. For patients without AIDS, the mean number of inpatient days PPY was 1.08 (95% confidence interval [CI]: 0.97-1.19 for the HAART group versus 3.73 (95% CI: 3.55-3.97 for the No-ART group, and 8.71 (95% CI: 8.40-9.03 versus 4.35 (95% CI: 4.12-5.61, respectively, for mean number of outpatient visits PPY. Average service provision PPY was $950 for the No-ART group versus $1,342 and $793 PPY for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per life-year gained (LYG was $1,622 for scenario 1 and $675 for scenario 2. For patients with AIDS, mean inpatients days PPY was 2.04 (95% CI: 1.63-2.52 for the HAART versus 15.36 (95% CI: 13.97-16.85 for the No-ART group. Mean outpatient visits PPY was 7.62 (95% CI: 6.81-8.49 compared with 6.60 (95% CI: 5.69-7.62 respectively. Average service provision PPY was $3,520 for the No-ART group versus $1,513 and $964

  2. Cost-effectiveness of highly active antiretroviral therapy in South Africa.

    Science.gov (United States)

    Badri, Motasim; Maartens, Gary; Mandalia, Sundhiya; Bekker, Linda-Gail; Penrod, John R; Platt, Robert W; Wood, Robin; Beck, Eduard J

    2006-01-01

    Little information exists on the impact of highly active antiretroviral therapy (HAART) on health-care provision in South Africa despite increasing scale-up of access to HAART and gradual reduction in HAART prices. Use and cost of services for 265 HIV-infected adults without AIDS (World Health Organization [WHO] stage 1, 2, or 3) and 27 with AIDS (WHO stage 4) receiving HAART between 1995 and 2000 in Cape Town were compared with HIV-infected controls matched for baseline WHO stage, CD4 count, age, and socioeconomic status, who did not receive antiretroviral therapy (ART; No-ART group). Costs of service provision (January 2004 prices, USD 1 = 7.6 Rand) included local unit costs, and two scenarios for HAART prices for WHO recommended first-line regimens: scenario 1 used current South African public-sector ART drug prices of $730 per patient-year (PPY), whereas scenario 2 was based on the anticipated public-sector price for locally manufactured drug of $181 PPY. All analyses are presented in terms of patients without AIDS and patients with AIDS. For patients without AIDS, the mean number of inpatient days PPY was 1.08 (95% confidence interval [CI]: 0.97-1.19) for the HAART group versus 3.73 (95% CI: 3.55-3.97) for the No-ART group, and 8.71 (95% CI: 8.40-9.03) versus 4.35 (95% CI: 4.12-5.61), respectively, for mean number of outpatient visits PPY. Average service provision PPY was $950 for the No-ART group versus $1,342 and $793 PPY for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per life-year gained (LYG) was $1,622 for scenario 1 and $675 for scenario 2. For patients with AIDS, mean inpatients days PPY was 2.04 (95% CI: 1.63-2.52) for the HAART versus 15.36 (95% CI: 13.97-16.85) for the No-ART group. Mean outpatient visits PPY was 7.62 (95% CI: 6.81-8.49) compared with 6.60 (95% CI: 5.69-7.62) respectively. Average service provision PPY was $3,520 for the No-ART group versus $1,513 and $964 for the HAART group for scenario 1 and

  3. Cost-effectiveness of highly active antiretroviral therapy in South Africa.

    Directory of Open Access Journals (Sweden)

    Motasim Badri

    2006-01-01

    Full Text Available Little information exists on the impact of highly active antiretroviral therapy (HAART on health-care provision in South Africa despite increasing scale-up of access to HAART and gradual reduction in HAART prices.Use and cost of services for 265 HIV-infected adults without AIDS (World Health Organization [WHO] stage 1, 2, or 3 and 27 with AIDS (WHO stage 4 receiving HAART between 1995 and 2000 in Cape Town were compared with HIV-infected controls matched for baseline WHO stage, CD4 count, age, and socioeconomic status, who did not receive antiretroviral therapy (ART; No-ART group. Costs of service provision (January 2004 prices, USD 1 = 7.6 Rand included local unit costs, and two scenarios for HAART prices for WHO recommended first-line regimens: scenario 1 used current South African public-sector ART drug prices of $730 per patient-year (PPY, whereas scenario 2 was based on the anticipated public-sector price for locally manufactured drug of $181 PPY. All analyses are presented in terms of patients without AIDS and patients with AIDS. For patients without AIDS, the mean number of inpatient days PPY was 1.08 (95% confidence interval [CI]: 0.97-1.19 for the HAART group versus 3.73 (95% CI: 3.55-3.97 for the No-ART group, and 8.71 (95% CI: 8.40-9.03 versus 4.35 (95% CI: 4.12-5.61, respectively, for mean number of outpatient visits PPY. Average service provision PPY was $950 for the No-ART group versus $1,342 and $793 PPY for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per life-year gained (LYG was $1,622 for scenario 1 and $675 for scenario 2. For patients with AIDS, mean inpatients days PPY was 2.04 (95% CI: 1.63-2.52 for the HAART versus 15.36 (95% CI: 13.97-16.85 for the No-ART group. Mean outpatient visits PPY was 7.62 (95% CI: 6.81-8.49 compared with 6.60 (95% CI: 5.69-7.62 respectively. Average service provision PPY was $3,520 for the No-ART group versus $1,513 and $964 for the HAART group for scenario 1

  4. A low-cost hierarchical nanostructured beta-titanium alloy with high strength

    Science.gov (United States)

    Devaraj, Arun; Joshi, Vineet V.; Srivastava, Ankit; Manandhar, Sandeep; Moxson, Vladimir; Duz, Volodymyr A.; Lavender, Curt

    2016-01-01

    Lightweighting of automobiles by use of novel low-cost, high strength-to-weight ratio structural materials can reduce the consumption of fossil fuels and in turn CO2 emission. Working towards this goal we achieved high strength in a low cost β-titanium alloy, Ti–1Al–8V–5Fe (Ti185), by hierarchical nanostructure consisting of homogenous distribution of micron-scale and nanoscale α-phase precipitates within the β-phase matrix. The sequence of phase transformation leading to this hierarchical nanostructure is explored using electron microscopy and atom probe tomography. Our results suggest that the high number density of nanoscale α-phase precipitates in the β-phase matrix is due to ω assisted nucleation of α resulting in high tensile strength, greater than any current commercial titanium alloy. Thus hierarchical nanostructured Ti185 serves as an excellent candidate for replacing costlier titanium alloys and other structural alloys for cost-effective lightweighting applications. PMID:27034109

  5. Advanced gasifier and water gas shift technologies for low cost coal conversion to high hydrogen syngas

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, Andrew Kramer [Gas Technology Inst., Des Plaines, IL (United States)

    2016-09-30

    The Gas Technology Institute (GTI) and team members RTI International (RTI), Coanda Research and Development, and Nexant, are developing and maturing a portfolio of technologies to meet the United States Department of Energy (DOE) goals for lowering the cost of producing high hydrogen syngas from coal for use in carbon capture power and coal-to-liquids/chemicals. This project matured an advanced pilot-scale gasifier, with scalable and commercially traceable components, to readiness for use in a first-of-a-kind commercially-relevant demonstration plant on the scale of 500-1,000 tons per day (TPD). This was accomplished through cold flow simulation of the gasifier quench zone transition region at Coanda and through an extensive hotfire gasifier test program on highly reactive coal and high ash/high ash fusion temperature coals at GTI. RTI matured an advanced water gas shift process and catalyst to readiness for testing at pilot plant scale through catalyst development and testing, and development of a preliminary design basis for a pilot scale reactor demonstrating the catalyst. A techno-economic analysis was performed by Nexant to assess the potential benefits of the gasifier and catalyst technologies in the context of power production and methanol production. This analysis showed an 18%reduction in cost of power and a 19%reduction in cost of methanol relative to DOE reference baseline cases.

  6. Advanced Materials and Manufacturing for Low-Cost, High-Performance Liquid Rocket Combustion Chambers

    Science.gov (United States)

    Williams, Brian E.; Arrieta, Victor M.

    2013-01-01

    A document describes the low-cost manufacturing of C103 niobium alloy combustion chambers, and the use of a high-temperature, oxidation-resistant coating that is superior to the standard silicide coating. The manufacturing process involved low-temperature spray deposition of C103 on removable plastic mandrels produced by rapid prototyping. Thin, vapor-deposited platinum-indium coatings were shown to substantially improve oxidation resistance relative to the standard silicide coating. Development of different low-cost plastic thrust chamber mandrel materials and prototyping processes (selective laser sintering and stereolithography) yielded mandrels with good dimensional accuracy (within a couple of mils) for this stage of development. The feasibility of using the kinetic metallization cold-spray process for fabrication of free-standing C1O3 thrusters on removable plastic mandrels was also demonstrated. The ambient and elevated temperature mechanical properties of the material were shown to be reasonably good relative to conventionally processed C103, but the greatest potential benefit is that coldsprayed chambers require minimal post-process machining, resulting in substantially lower machining and material costs. The platinum-iridium coating was shown to provide greatly increased oxidation resistance over the silicide when evaluated through oxyacetylene torch testing to as high as 300 F (= 150 C). The iridium component minimizes reaction with the niobium alloy chamber at high temperatures, and provides the high-temperature oxidation resistance needed at the throat.

  7. Novel, low cost, highly effective, handmade steroid pellets for experimental studies.

    Directory of Open Access Journals (Sweden)

    Ana Sahores

    Full Text Available The basic component of Silastic® glue (Dow Corning used to prepare Silastic® pellets is polydimethylsiloxane. This compound is also present in other commercial adhesives such as FASTIX® (Akapol SA that are available in any store for that category. In the present study we developed low cost, easy to prepare handmade steroid pellets (HMSP by mixing 17β-estradiol, progesterone or other synthetic steroids with FASTIX® adhesive. We assessed serum levels of 17β-estradiol, progesterone, prolactin and luteinizing hormone in ovariectomized mice treated for 24 and 48 h or 7, 14 and 28 days with 20 µg or 5 mg of 17β-estradiol or 5 mg progesterone HMSP. We found a time dependent and significant increase in the levels of both natural hormones, and a downregulation of serum luteinizing hormone levels, while both 17β-estradiol doses increased serum prolactin. Uterine weights at sacrifice and histological examination of the uteri and the mammary glands correlated with estrogen or progestin action. Finally, we evaluated the biological effects of HMSP compared to commercial pellets or daily injections in the stimulation or inhibition of hormone dependent mammary tumor growth, and found that HMSP were as effective as the other methods of hormone administration. These data show that HMSP represent a useful, low cost, easily accessible method for administering steroids to mice.

  8. The cost-effectiveness of intervening in low and high HIV prevalence areas in South Africa

    Directory of Open Access Journals (Sweden)

    Josue Mbonigaba

    2013-05-01

    Full Text Available This research compared the cost-effectiveness of a set of HIV/AIDS interventions in a low HIV prevalence area (LPA and in a high HIV prevalence area (HPA in South Africa. The rationale for this analysis was to assess the interaction dynamics between a specific HIV/AIDS intervention and an area of implementation and the effects of these dynamics on the cost-effectiveness of such an HIV/AIDS intervention. A pair of Markov models was evaluated for each intervention; one model for a HPA and another for an LPA and the cost-effectiveness of that intervention was compared across an LPA and a HPA. The baseline costs and health outcomes in each area were collected from the literature. To depict interaction dynamics between an HIV/AIDS intervention and an area of implementation, baseline health outcomes collected in each area, were adjusted over time based on the patterns of the projections observed in the AIDS model of the Actuarial Society of South Africa (ASSA2008. The study found that the VCT and treatment of STDs were equally cost-effective in an LPA and in a HPA while PMTCT and HAART were more cost-effective in an LPA than in a HPA. As a policy proposal, resources earmarked to non-ARV based interventions (VCT and treatment of STDs should  be equally shared across an LPA and a HPA while  more of the resources reserved for ARV-based interventions (PMTCT and HAART should go in an LPA in order to increase efficiency.

  9. Research on producing high quality diffractive optical elements in volume at a low cost

    Science.gov (United States)

    Daschner, Walter

    1997-11-01

    Diffractive Optical Elements (DOEs) can be utilized in a variety of possible applications in modern optical, as well as optoelectronic systems. The current roadblock for application of DOEs in consumer products is not the feasibility of the approach, as numerous applications have been successfully demonstrated. In order for the breakthrough to occur in industry, it is important to determine a convenient and cost-effective method for manufacturing DOEs. The industry will improve the design of their legacy systems and start including DOEs only when the performance improvement (which the utilization of DOEs achieves), can be purchased with a minimal amount of additional capital investment and cost-per-part. Therefore, the focus of this dissertation was to find a cost-effective method of fabricating large quantities of DOEs with currently available fabrication tools. Direct-write approaches were investigated to fabricate high-quality masters for a subsequent replication procedure based upon molding or casting. Electron-Beam Direct-Write was carried-out in a positive Novolac-based photo-resist which provides dry etch resistivity. Another focus of this development was to find a way to minimize Electron-Beam writing time for a given element. Proximity effect characterization and compensation has been carried-out in order to increase the fidelity of the pattern reproduction. A dry-etching procedure has been developed in order to transfer resist profiles into the substrate material. During this transfer step, the etch rates of resist and substrate material can be controlled; this in turn allows a choice of final feature depth in the substrate material (depending on refractive index and wavelength in use). Two Gray-Scale masking approaches were developed to allow the cost-effective mass fabrication of DOEs in a single optical exposure step. Thin film evaporation of Inconel achieves high-quality masks at a high price. High Energy Beam Sensitive Glass, the second mask material

  10. Minimum Cost Nanosatellite Launch System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Delta Velocity Corporation proposes the development of a very low cost, highly responsive nanosat launch system. We propose to develop an integrated propulsion...

  11. Low Cost Phased Array Antenna System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — JEM Engineering proved the technical feasibility of the FlexScan array?a very low-cost, highly-efficient, wideband phased array antenna?in Phase I, and stands ready...

  12. Design and Build of an Electrical Machines’ High Speed Measurement System at Low Cost

    Directory of Open Access Journals (Sweden)

    Constantinos C. Kontogiannis

    2014-01-01

    Full Text Available The principal objective of this paper is to demonstrate the capability of high speed measurement and acquisition equipment design and build in the laboratory at a very low cost. The presented architecture employees highly integrated market components eliminating thus the complexity of the hardware and software stack. The key element of the proposed system is a Hi-Speed USB to Serial/FIFO development module that is provided with full software and driver support for most popular operating systems. This module takes over every single task needed to get the data from the A/D to the user software gluelessly and transparently, solving this way the most difficult problem in data acquisition systems which is the fast and reliable communication with a host computer. Other ideas tested and included in this document offer Hall Effect measuring solutions using some excellent features and very low cost ICs widely available on the market today.

  13. A new aluminium-ion battery with high voltage, high safety and low cost.

    Science.gov (United States)

    Sun, Haobo; Wang, Wei; Yu, Zhijing; Yuan, Yan; Wang, Shuai; Jiao, Shuqiang

    2015-07-28

    A new kind of Al-ion battery with carbon paper as the cathode, high-purity Al foil as the anode and ionic liquid as the electrolyte is proposed in this work. The significance of the presented battery is going to be an extremely high average voltage plateau of ca. 1.8 V vs. Al(3+)/Al.

  14. MAINTAINING HIGH RESOLUTION MASS SPECTROMETRY CAPABILITIES FOR NATIONAL NUCLEAR SECURITY ADMINISTRATION APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Wyrick, S.; Cordaro, J.; Reeves, G.; Mcintosh, J.; Mauldin, C.; Tietze, K.; Varble, D.

    2011-06-06

    The Department of Energy (DOE) National Nuclear Security Administration (NNSA) has a specialized need for analyzing low mass gas species at very high resolutions. The currently preferred analytical method is electromagnetic sector mass spectrometry. This method allows the NNSA Nuclear Security Enterprise (NSE) to resolve species of similar masses down to acceptable minimum detection limits (MDLs). Some examples of these similar masses are helium-4/deuterium and carbon monoxide/nitrogen. Through the 1980s and 1990s, there were two vendors who supplied and supported these instruments. However, with declining procurements and down turns in the economy, the supply of instruments, service and spare parts from these vendors has become less available, and in some cases, nonexistent. The largest NSE user of this capability is the Savannah River Site (SRS), located near Aiken, South Carolina. The Research and Development Engineering (R&DE) Group in the Savannah River National Laboratory (SRNL) investigated the areas of instrument support that were needed to extend the life cycle of these aging instruments. Their conclusions, as to the focus areas of electromagnetic sector mass spectrometers to address, in order of priority, were electronics, software and hardware. Over the past 3-5 years, the R&DE Group has designed state of the art electronics and software that will allow high resolution legacy mass spectrometers, critical to the NNSA mission, to be operated for the foreseeable future. The funding support for this effort has been from several sources, including the SRS Defense Programs, NNSA Readiness Campaign, Pantex Plant and Sandia National Laboratory. To date, electronics systems have been upgraded on one development system at SRNL, two production systems at Pantex and one production system at Sandia National Laboratory. An NSE working group meets periodically to review strategies going forward. The R&DE Group has also applied their work to the electronics for a

  15. An advanced low-cost workstation for NDE of high-risk components, experiences and trends

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Ona, R.; Cabrera, E.; Aldea, J.; Ortega, J. [Tecnatom, Madrid (Spain)

    1994-12-31

    Mechanized inspection by means of ultrasonic techniques is widely used when high levels of reliability are required. For such inspections it is necessary that automatic data acquisition, processing and display systems be available. This paper describes the main characteristics of the SUMIAD 3 system. The system is designed on the basis of low cost elements (PC technology), in a way ensuring coverage of the different phases of Inspection, Preparation, Execution and Evaluation.

  16. Computer Vision Approach for Low Cost, High Precision Measurement of Grapevine Trunk Diameter in Outdoor Conditions

    OpenAIRE

    Pérez, Diego Sebastián; Bromberg, Facundo; Antivilo, Francisco Gonzalez

    2014-01-01

    Trunk diameter is a variable of agricultural interest, used mainly in the prediction of fruit trees production. It is correlated with leaf area and biomass of trees, and consequently gives a good estimate of the potential production of the plants. This work presents a low cost, high precision method for the measurement of trunk diameter of grapevines based on Computer Vision techniques. Several methods based on Computer Vision and other techniques are introduced in the literature. These metho...

  17. Big data in health care: using analytics to identify and manage high-risk and high-cost patients.

    Science.gov (United States)

    Bates, David W; Saria, Suchi; Ohno-Machado, Lucila; Shah, Anand; Escobar, Gabriel

    2014-07-01

    The US health care system is rapidly adopting electronic health records, which will dramatically increase the quantity of clinical data that are available electronically. Simultaneously, rapid progress has been made in clinical analytics--techniques for analyzing large quantities of data and gleaning new insights from that analysis--which is part of what is known as big data. As a result, there are unprecedented opportunities to use big data to reduce the costs of health care in the United States. We present six use cases--that is, key examples--where some of the clearest opportunities exist to reduce costs through the use of big data: high-cost patients, readmissions, triage, decompensation (when a patient's condition worsens), adverse events, and treatment optimization for diseases affecting multiple organ systems. We discuss the types of insights that are likely to emerge from clinical analytics, the types of data needed to obtain such insights, and the infrastructure--analytics, algorithms, registries, assessment scores, monitoring devices, and so forth--that organizations will need to perform the necessary analyses and to implement changes that will improve care while reducing costs. Our findings have policy implications for regulatory oversight, ways to address privacy concerns, and the support of research on analytics. Project HOPE—The People-to-People Health Foundation, Inc.

  18. Cost estimate of high-level radioactive waste containers for the Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Russell, E.W.; Clarke, W. [Lawrence Livermore National Lab., CA (United States); Domian, H.A. [Babcock and Wilcox Co., Lynchburg, VA (United States); Madson, A.A. [Kaiser Engineers California Corp., Oakland, CA (United States)

    1991-08-01

    This report summarizes the bottoms-up cost estimates for fabrication of high-level radioactive waste disposal containers based on the Site Characterization Plan Conceptual Design (SCP-CD). These estimates were acquired by Babcock and Wilcox (B&S) under sub-contract to Lawrence Livermore National Laboratory (LLNL) for the Yucca Mountain Site Characterization Project (YMP). The estimates were obtained for two leading container candidate materials (Alloy 825 and CDA 715), and from other three vendors who were selected from a list of twenty solicited. Three types of container designs were analyzed that represent containers for spent fuel, and for vitrified high-level waste (HLW). The container internal structures were assumed to be AISI-304 stainless steel in all cases, with an annual production rate of 750 containers. Subjective techniques were used for estimating QA/QC costs based on vendor experience and the specifications derived for the LLNL-YMP Quality Assurance program. In addition, an independent QA/QC analysis is reported which was prepared by Kasier Engineering. Based on the cost estimates developed, LLNL recommends that values of $825K and $62K be used for the 1991 TSLCC for the spent fuel and HLW containers, respectively. These numbers represent the most conservative among the three vendors, and are for the high-nickel anstenitic steel (Alloy 825). 6 refs., 7 figs.

  19. [High cost drugs for rare diseases in Brazil: the case of lysosomal storage disorders].

    Science.gov (United States)

    de Souza, Mônica Vinhas; Krug, Bárbara Corrêa; Picon, Paulo Dornelles; Schwartz, Ida Vanessa Doederlein

    2010-11-01

    This paper approaches in a critical way aspects of Brazilian public policies for drugs, emphasizing those classified as high cost and for rare diseases. The lysosomal storage diseases was taken as an example because of their rarity and the international trend for the development of new drugs for their treatment, all at high costs. Three lysosomal storage diseases were approached: Gaucher disease, Fabry disease and mucopolysaccharidosis type I. Gaucher disease has its treatment drug licensed in Brazil and guidelines for its use are established through a clinical protocol by the Ministry of Health. The others have their drug treatments registered in Brazil; however, no treatment guidelines for them have been developed by the government. The objective of the paper was to foster the discussion on the role of health technology assessment for high-cost drugs for rare diseases in Brazil, emphasizing the need for establishing health policies with legitimacy towards these diseases. Despite the difficulties in establishing a health policy for each rare disease, it is possible to create rational models to deal with this growing challenge.

  20. A High-performance Low Cost Inverse Integer Transform Architecture for AVS Video Standard

    Institute of Scientific and Technical Information of China (English)

    LI Yu-fei; WANG Qin; FU Yu-zhuo

    2008-01-01

    A high-performance, low cost inverse integer transform architecture for advanced video standard (AVS) video coding standard was presented. An 8×8 inverse integer transform is required in AVS video system which is compute-intensive. A hardware transform is inevitable to compute the transform for the real-time ap-plication. Compared with the 4×4 transform for H.264/AVC, the 8×8 integer transform is much more complex and the coefficient in the inverse transform matrix Ts is not inerratic as that in H.264/AVC. Dividing the Ts into matrix S8 and R8, the proposed architecture is implemented with the adders and the specific CSA-trees instead of multipliers, which are area and time consuming. The architecture obtains the data processing rate up to 8 pixels per-cycle at a low cost of area. Synthesized to TSMC 0.18 μm COMS process, the architecture attains the operating frequency of 300 MHz at cost of 34 252 gates with a 2-stage pipeline scheme. A reusable scheme is also introduced for the area optimization, which results in the operating frequency of 143 MHz at cost of only 19 758 gates.

  1. Low-cost fabrication of high efficiency solid-state neutron detectors

    Science.gov (United States)

    Wu, Jia-Woei; Huang, Kuan-Chih; Weltz, Adam; English, Erik; Hella, Mona M.; Dahal, Rajendra; Lu, James J.-Q.; Danon, Yaron; Bhat, Ishwara B.

    2016-05-01

    The development of high-efficiency solid state thermal neutron detectors at low cost is critical for a wide range of civilian and defense applications. The use of present neutron detector system for personal radiation detection is limited by the cost, size, weight and power requirements. Chip scale solid state neutron detectors based on silicon technology would provide significant benefits in terms of cost, volume, and allow for wafer level integration with charge preamplifiers and readout electronics. In this paper, anisotropic wet etching of (110) silicon wafers was used to replace deep reactive ion etching (DRIE) to produce microstructured neutron detectors with lower cost and compatibility with mass production. Deep trenches were etched by 30 wt% KOH at 85°C with a highest etch ratio of (110) to (111). A trench-microstructure thermal neutron detector described by the aforementioned processes was fabricated and characterized. The detector—which has a continuous p+-n junction diode—was filled with enriched boron (99% of 10B) as a neutron converter material. The device showed a leakage current of ~ 6.7 × 10-6 A/cm2 at -1V and thermal neutron detection efficiency of ~16.3%. The detector uses custom built charge pre-amplifier, a shaping amplifier, and an analogto- digital converter (ADC) for data acquisition.

  2. Low-cost, high-performance and efficiency computational photometer design

    Science.gov (United States)

    Siewert, Sam B.; Shihadeh, Jeries; Myers, Randall; Khandhar, Jay; Ivanov, Vitaly

    2014-05-01

    Researchers at the University of Alaska Anchorage and University of Colorado Boulder have built a low cost high performance and efficiency drop-in-place Computational Photometer (CP) to test in field applications ranging from port security and safety monitoring to environmental compliance monitoring and surveying. The CP integrates off-the-shelf visible spectrum cameras with near to long wavelength infrared detectors and high resolution digital snapshots in a single device. The proof of concept combines three or more detectors into a single multichannel imaging system that can time correlate read-out, capture, and image process all of the channels concurrently with high performance and energy efficiency. The dual-channel continuous read-out is combined with a third high definition digital snapshot capability and has been designed using an FPGA (Field Programmable Gate Array) to capture, decimate, down-convert, re-encode, and transform images from two standard definition CCD (Charge Coupled Device) cameras at 30Hz. The continuous stereo vision can be time correlated to megapixel high definition snapshots. This proof of concept has been fabricated as a fourlayer PCB (Printed Circuit Board) suitable for use in education and research for low cost high efficiency field monitoring applications that need multispectral and three dimensional imaging capabilities. Initial testing is in progress and includes field testing in ports, potential test flights in un-manned aerial systems, and future planned missions to image harsh environments in the arctic including volcanic plumes, ice formation, and arctic marine life.

  3. Acute administration of high dose trimetazidine inhibits pentylenetetrazol-induced seizures in rats

    Directory of Open Access Journals (Sweden)

    Serkan GURGUL

    2017-03-01

    Full Text Available Objective: Resistant epilepsy is widely seen in clinical settings manipulate the researchers to pursuit novel anti-epileptic treatments. Although trimetazidine (TMZ is commonly used in the treatment of angina and ischemic diseases, it is considered that the drug may be beneficial in the treatment of epileptic seizures and convulsions. We aimed to evaluate electrophysiologically the protective effects of high dose acute TMZ on epileptic seizures and convulsions in a rat model of epilepsy induced by pentilentetrazol (PTZ. Method: Forty-eight male Sprague-Dawley rats were used for the EEG evaluation (Group-A; n=24 and behavioral assessment (Group-B; n=24. Grup-A1 and Grup-B1 were determined as control group and given no medication. 35 mg/kg (Group-A2, -A3 and -A4 and 70 mg/kg (Group-B2, -B3 and -B4 of PTZ were administered intraperitoneally (ip. so as to generate seizures and convulsions. Group-A2 and Group-B2 were treated with saline. 40 mg/kg (Grup-A3 and Grup-B3 and 80 mg/kg of TMZ (Group-A4 and Group-B4 were administered to the treatment groups by ip. Brain malondialdehyde (MDA levels, spike-percentage values, Racine’s Convulsion Scale (RCS scores and "first myoclonic jerk (FMJ" latencies of each rat were determined. Results: Brain MDA levels, spike-percentage values, RCS scores, and FMJ latencies of Group-A2 and Group-B2 were significantly increased compared to those of the control’s (Grup-A1 and Grup-B1 (P<0.05 for all comparisons. However, in TMZ treated groups (Group-A3 and -A4; Group-B3 and -B4 the elevated values of these parameters were found to be significantly decreased (P<0.05 for all comparisons. Conclusions: This study has demonstrated that the high dose acute TMZ administration may prevent PTZ-induced seizures and convulsions in rats. Furthermore, it can be also said that TMZ has a neuroprotective effects on oxidative stress associated with PTZ. Therefore, it may be considered for use with therapeutic purposes of TMZ in

  4. Design and Construction of Low Cost High Voltage dc Power Supply for Constant Power Operation

    Science.gov (United States)

    Kumar, N. S.; Jayasankar, V.

    2013-06-01

    Pulsed load applications like laser based systems need high voltage dc power supplies with better regulation characteristics. This paper presents the design, construction and testing of dc power supply with 1 kV output at 300 W power level. The designed converter has half bridge switched mode power supply (SMPS) configuration with 20 kHz switching. The paper covers the design of half bridge inverter, closed loop control, High frequency transformer and other related electronics. The designed power supply incorporates a low cost OPAMP based feedback controller which is designed using small signal modelling of the converter. The designed converter was constructed and found to work satisfactorily as per the specifications.

  5. Estimated Costs of Dental Care due to Dental Decay in Mexican High School Students

    OpenAIRE

    2010-01-01

    Objective: Estimate the cost of dental care generated by the dental decay prevalence in high school students at Universidad Nacional Autónoma de México (UNAM). Methods: A cross-sectional study was carried out with a population of 78,870 high schoolers (conducted between the years 2003 and 2005). The need for dental caries treatment was determined by the decayed, missing and filled teeth index (DMFT) as it is indicated at the Automated Medical Exam (EMA, acronym in Spanish). The estimation of ...

  6. Project GeoWSN: High precision but low-cost GNSS landslide monitoring in Austria

    Science.gov (United States)

    Koch, Daniel; Brandstätter, Michael; Kühtreiber, Norbert

    2014-05-01

    At present, GNSS monitoring of landslides is an accepted and approved method to detect movements of slopes at risk in the sub-centimetre level. However, high-precision geodetic GNSS-receivers are expensive, therefore this monitoring method is not widely applied. Recently low-cost GNSS-receivers are conquering the geodetic market and are well suited for a cost effective and yet precise GNSS-monitoring. During the project GeoWSN, which was funded by the Austrian Research Promotion Agency (FFG), an applicable low-cost monitoring system was developed at Graz University of Technology. The system is based on a so-called Wireless Sensor Network (WSN) consisting of low-cost GNSS-receivers, temperature and humidity sensors and inertial measurement units. Additionally energy-harvesting technologies and power-saving algorithms provide that the system is energy- autarkic. For real-time applications, a communication link between the sensor nodes is implemented. The relative positioning method RTK (Real Time Kinematic) is applied to reach the highest possible accuracy. The GeoWSN sensor nodes enable the detection of possible movements in the real-time processed positions of the sensor nodes. To ensure a real-time evaluation and interpretation of the data, the current status of the slope can be acquired by a local warning centre. Therefore, affected people can be warned within a short latency. Several test-scenarios have shown the acceptance of the system at the warning centre of Styria, Austria. This contribution should give an overview of the main idea of a low-cost warning system and results of the project GeoWSN.

  7. The High Cost of High School Failure in New Jersey. School Choice Issues in the State

    Science.gov (United States)

    Gottlob, Brian J.

    2008-01-01

    State and local education officials in New Jersey tout the state's high school graduation rate as the highest in the nation. At the same time, independent research indicates that 40 percent of students in Newark drop out and only half of African-American students in urban districts graduate. Meanwhile, there is increasing concern in New Jersey…

  8. 7 CFR Appendix A to Part 277 - Principles for Determining Costs Applicable to Administration of the Food Stamp Program by State...

    Science.gov (United States)

    2010-01-01

    ..., or holiday premiums, and fringe benefits) may be allowed in lieu of actual allowable indirect cost... functions related to the Program is allowable. (5) Bonding. Costs of premiums on bonds covering employees... cost under any recognized method of pricing consistently applied. Incoming transportation charges are a...

  9. The High Cost of Failing to Reform Public Education in Indiana. School Choice Issues in the State

    Science.gov (United States)

    Gottlob, Brian J.

    2006-01-01

    This study documents the public costs of high school dropouts in Indiana, and examines how school choice would provide large public benefits by increasing the graduation rate in Indiana public schools. It calculates the annual cost of high school dropouts in Indiana due to lower state income tax payments, increased reliance on Medicaid, and…

  10. 76 FR 60031 - Notice of Order: Revisions to Enterprise Public Use Database Incorporating High-Cost Single...

    Science.gov (United States)

    2011-09-28

    ... AGENCY Notice of Order: Revisions to Enterprise Public Use Database Incorporating High-Cost Single-Family... contains Enterprise single-family and multifamily mortgage loan-level data reported to FHFA by the... data characteristics of single-family high-cost loans purchased and securitized by the Enterprises...

  11. 76 FR 77533 - Notice of Order: Revisions to Enterprise Public Use Database Incorporating High-Cost Single...

    Science.gov (United States)

    2011-12-13

    ... AGENCY Notice of Order: Revisions to Enterprise Public Use Database Incorporating High-Cost Single-Family... matrices to include certain data fields for high-cost single-family loans purchased and securitized by the... rate spread field has been corrected in the Single Family Census Tract Data Set. Both files...

  12. Silicon carbide high performance optics: a cost-effective, flexible fabrication process

    Science.gov (United States)

    Casstevens, John M.; Rashed, Abuagela; Plummer, Ronald; Bray, Don; Gates, Rob L.; Lara-Curzio, Edgar; Ferber, Matt K.; Kirkland, Tim

    2001-12-01

    Silicon carbide may well be the best known material for the manufacture of high performance optical components. This material offers many advantages over glasses and metals that have historically been used in high performance optical systems. A combination of extremely high specific stiffness (E/r), high thermal conductivity and outstanding dimensional stability make silicon carbide superior overall to beryllium and low-expansion glass ceramics. A major impediment to wide use of silicon carbide in optical systems has been the cost associated with preliminary shaping and final finishing of silicon carbide. Because silicon carbide is an extremely hard and strong material, precision machining can only be done with expensive diamond tooling on very stiff high quality machine tools. Near-net-shape slip casting of silicon carbide can greatly reduce the cost of silicon carbide mirror substrates but this process still requires significant diamond grinding of the cast components. The process described here begins by machining the component from all special type of graphite. This graphite can rapidly be machined with conventional multi-axis CNC machine tools to achieve any level of complexity and lightweighting required. The graphite is then directly converted completely to silicon carbide with very small and very predictable dimensional change. After conversion to silicon carbide the optical surface is coated with very fine grain CVD silicon carbide which is easily polished to extreme smoothness. Details of the fabrication process are described and photos and performance specifications of an eight-inch elliptical demonstration mirror are provided.

  13. Designing HIGH-COST medicine: hospital surveys, health planning, and the paradox of progressive reform.

    Science.gov (United States)

    Perkins, Barbara Bridgman

    2010-02-01

    Inspired by social medicine, some progressive US health reforms have paradoxically reinforced a business model of high-cost medical delivery that does not match social needs. In analyzing the financial status of their areas' hospitals, for example, city-wide hospital surveys of the 1910s through 1930s sought to direct capital investments and, in so doing, control competition and markets. The 2 national health planning programs that ran from the mid-1960s to the mid-1980s continued similar strategies of economic organization and management, as did the so-called market reforms that followed. Consequently, these reforms promoted large, extremely specialized, capital-intensive institutions and systems at the expense of less complex (and less costly) primary and chronic care. The current capital crisis may expose the lack of sustainability of such a model and open up new ideas and new ways to build health care designed to meet people's health needs.

  14. Inkjet printing of novel wideband and high gain antennas on low-cost paper substrate

    KAUST Repository

    Cook, Benjamin Stassen

    2012-09-01

    A complete characterization of the inkjet printing process using metallic nanoparticle inks on a paper substrate for microwave frequencies up to 12.5 GHz as well as its application to low-cost, high gain and wideband antenna design are demonstrated in this work. Laser and heat sintering of metallic nanoparticles are compared on paper substrate for the first time which demonstrate immense cost and time benefits of laser sintering. The antennas fabricated using the characterized process include a Vivaldi for the UWB band which exhibits a significantly higher gain of up to 8 dBi as compared to the currently published inkjet printed antennas, and a novel slow-wave log periodic dipole array which employs a new miniaturization technique to show 20% width reduction. © 1963-2012 IEEE.

  15. Locating operations in high labor cost countries – Evidence from Spain

    Directory of Open Access Journals (Sweden)

    Angel Diaz

    2017-06-01

    Full Text Available The location of operations in high labor cost countries is increasingly discussed in the media, in part for recent declarations and actions from the president of USA, Donald Trump. While this particular instance can be labeled as populist or protectionist, the factors underlying the debate are extremely important: advances in systematic increases in productivity, low population growth, and the transfer of jobs to countries with lower labor costs are creating unemployment and underemployment in developed countries that could eventually result in protectionism and restrictions to free trade. This phenomenon has enormous social and economic implications, and has attracted considerable interest from researchers. In particular, this study provides empirical evidence of the location of manufacturing and services in the context of a European country (Spain, exploring the drivers, social implications and organizational theories that can explain it.

  16. Low-cost high-efficient 10-Watt X-band high-power amplifier

    NARCIS (Netherlands)

    Bent, G. van der; Hek, A.P. de; Bessemoulin, A.; Vliet, F.E. van

    2009-01-01

    A high power X-band amplifier with an output power over 10 Watts and a Power Added Efficiency (PAE) in excess of 40 percent has been developed. The design was fabricated in a 0.25 μm pHEMT GaAs process (WIN Semiconductor PP25-01). The small die area in combination with a 6-inch wafer technology prov

  17. Administration of G-CSF from day +6 post-allogeneic hematopoietic stem cell transplantation in children and adolescents accelerates neutrophil engraftment but does not appear to have an impact on cost savings.

    Science.gov (United States)

    O'Rafferty, Ciara; O'Brien, Mairead; Smyth, Elaine; Keane, Sinead; Robinson, Hillary; Lynam, Paul; O'Marcaigh, Aengus; Smith, Owen P

    2016-05-01

    G-CSF post-allogeneic HSCT accelerates neutrophil engraftment, but evidence that it impacts on cost-related outcomes is lacking. We performed a retrospective child and adolescent single-center cohort study examining G-CSF administration from Day +6 of allogeneic HSCT vs. ad hoc G-CSF use where clinically indicated. Forty consecutive children and adolescents undergoing allogeneic HSCT were included. End-points were as follows: time to engraftment; incidence of acute and chronic GvHD; number of patients alive at Day +100; 180-day TRM; post-transplant days in hospital; and cost of antimicrobials, TPN, and G-CSF usage. Neutrophil engraftment occurred earlier in the group that received G-CSF from Day +6. There was no difference between groups in any of the other end-points with the following exception: the cost of GCSF was significantly higher in the D + 6 G-CSF group. However, median G-CSF cost in this group amounted to only €280. There was a trend towards reduced cost of antimicrobials in the D + 6 G-CSF group, although this did not reach significance (p = 0.13). The median cost per patient of antimicrobial agents between groups differed by €1116. This study demonstrated the administration of G-CSF on Day +6 in pediatric HSCT to be safe. A further study using a larger cohort of patients is warranted to ascertain its true clinico-economic value.

  18. How high are the personnel costs for OSCE? A financial report on management aspects.

    Science.gov (United States)

    Rau, Thea; Fegert, Jörg; Liebhardt, Hubert

    2011-01-01

    The OSCE (objective structured clinical examination) was put to the test in order to assess the clinical practical skills of students in medical studies in the medical faculties. For the implementation of an OSCE, a large number of personnel is necessary. In particular for subjects with limited resources, therefore, efficient cost planning is required. In the winter semester 09/10, the Department of Neurology at the Medical Faculty of the University of Ulm introduced the OSCE as a pilot project. A financial report retrospectively shows the personnel expenses. The report is intended as an example for an insight into the resources needed for the OSCE with simulated patients. Included in the calculation of the financial costs of the OSCE were: employment, status of staff involved in the OSCE, subject-matter and temporal dimension of the task. After the exam, acceptance of the examination format was reviewed by a focus group interview with the teachers and students. The total expenses for the personnel involved in the OSCE amounted to 12,468 €. The costing of the clinic's share was calculated at 9,576 €. Tuition fees from the students have been used to the amount of 2.892 €. For conversion of total expenditure to the number of examines the sum of 86 € per student was calculated. Both students and teachers confirmed the validity of the OSCE and recognised the added value in the learning effects. The high acceptance of the OSCE in neurology by both students and teachers favours maintaining the test format. Against the background of the high financial and logistical costs, however, in individual cases it should be assessed how in the long-term efficient examination procedure will be possible.

  19. Development of High Rate Coating Technology for Low Cost Electrochromic Dynamic Windows

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, B.; Joshi, Ajey

    2013-03-31

    Objectives of the Project: The objective of this project was to develop and demonstrate the feasibility of depositing critical electrochromic layers at high rate using new novel vacuum coating sources, to develop a full electrochromic process flow by combining conventional processes with new deposition sources, to characterize, test, evaluate, and optimize the resulting coatings and devices, and, to demonstrate an electrochromic device using the new process flow and sources. As addendum objectives, this project was to develop and demonstrate direct patterning methods with novel integration schemes. The long term objective, beyond this program, is to integrate these innovations to enable production of low-cost, high-performance electrochromic windows produced on highly reliable and high yielding manufacturing equipment and systems.

  20. High systemic availability of core-crosslinked polymeric micelles after subcutaneous administration

    NARCIS (Netherlands)

    Hu, Q.; Prakash, Jai; Rijcken, C.J.F.; Hennink, W.E.; Storm, Gerrit

    2016-01-01

    Covalent entrapment of drug molecules within core-crosslinked polymeric micelles (CCPM) represents an attractive approach to improve their therapeutic index. As an alternative to the most commonly employed intravenous (i.v.) route, subcutaneous (s.c.) administration offers the possibility of

  1. High systemic availability of core-crosslinked polymeric micelles after subcutaneous administration

    NARCIS (Netherlands)

    Hu, Q.; Prakash, Jai; Rijcken, C.J.F.; Hennink, W.E.; Storm, Gerrit

    2016-01-01

    Covalent entrapment of drug molecules within core-crosslinked polymeric micelles (CCPM) represents an attractive approach to improve their therapeutic index. As an alternative to the most commonly employed intravenous (i.v.) route, subcutaneous (s.c.) administration offers the possibility of self-ad

  2. Thin film CIGS photovoltaic modules: monolithic integration and advanced packaging for high performance, high reliability and low cost

    Science.gov (United States)

    Eldada, Louay

    2011-01-01

    In recent years, thin-film photovoltaic companies started realizing their low manufacturing cost potential, and have been grabbing an increasingly larger market share. Copper Indium Gallium Selenide (CIGS) is the most promising thin-film PV material, having demonstrated the highest energy conversion efficiency in both cells and modules. However, most CIGS manufacturers still face the challenge of delivering a reliable and rapid manufacturing process that can scale effectively and deliver on the promise of this material system. HelioVolt has developed a reactive transfer process for CIGS absorber formation that has the benefits of good compositional control, and a fast high-quality CIGS reaction. The reactive transfer process is a two stage CIGS fabrication method. Precursor films are deposited onto substrates and reusable cover plates in the first stage, while in the second stage the CIGS layer is formed by rapid heating with Se confinement. HelioVolt also developed best-in-class packaging technologies that provide unparalleled environmental stability. High quality CIGS films with large grains were fabricated on the production line, and high-performance highreliability monolithic modules with a form factor of 120 cm × 60 cm are being produced at high yield and low cost. With conversion efficiency levels around 14% for cells and 12% for modules, HelioVolt is commercializing the process on its first production line with 20 MW capacity, and is planning its next GW-scale factory.

  3. Schistosomiasis and soil-transmitted helminth control in Niger: cost effectiveness of school based and community distributed mass drug administration [corrected].

    Directory of Open Access Journals (Sweden)

    Jacqueline Leslie

    2011-10-01

    Full Text Available BACKGROUND: In 2004 Niger established a large scale schistosomiasis and soil-transmitted helminths control programme targeting children aged 5-14 years and adults. In two years 4.3 million treatments were delivered in 40 districts using school based and community distribution. METHOD AND FINDINGS: Four districts were surveyed in 2006 to estimate the economic cost per district, per treatment and per schistosomiasis infection averted. The study compares the costs of treatment at start up and in a subsequent year, identifies the allocation of costs by activity, input and organisation, and assesses the cost of treatment. The cost of delivery provided by teachers is compared to cost of delivery by community distributers (CDD. The total economic cost of the programme including programmatic, national and local government costs and international support in four study districts, over two years, was US$ 456,718; an economic cost/treatment of $0.58. The full economic delivery cost of school based treatment in 2005/06 was $0.76, and for community distribution was $0.46. Including only the programme costs the figures are $0.47 and $0.41 respectively. Differences at sub-district are more marked. This is partly explained by the fact that a CDD treats 5.8 people for every one treated in school. The range in cost effectiveness for both direct and direct and indirect treatments is quantified and the need to develop and refine such estimates is emphasised. CONCLUSIONS: The relative cost effectiveness of school and community delivery differs by country according to the composition of the population treated, the numbers targeted and treated at school and in the community, the cost and frequency of training teachers and CDDs. Options analysis of technical and implementation alternatives including a financial analysis should form part of the programme design process.

  4. Improved breast cancer biomarker detection through a simple, high frequency, low cost external proficiency testing program.

    Science.gov (United States)

    Hung, Tawny; Wolber, Robert; Garratt, John; Kalloger, Steven; Gilks, C Blake

    2010-12-01

    We describe a simple, low cost, high frequency immunohistochemistry external proficiency testing program, and show how its use can lead to improved breast cancer biomarker detection. Over a 30 month period in British Columbia, Canada, we used tissue microarray slides to follow the performance of twelve clinical laboratories in nine separate external proficiency testing runs. Sensitivity for detection of oestrogen receptor (ER), progesterone receptor (PR), and HER2 were calculated for each laboratory, biomarker, and run. Mean sensitivities for detection of ER, PR, and HER2 were 97.1%, 84.8%, and 90.7%, respectively. HER2 sensitivity improved over time, from 87.0% to 92.9% (p=0.04), with a trend towards improvement seen for PR (81.9-88.1%, p=0.13). ER sensitivities were high throughout the test period. Improvements occurred without mandating any specific laboratory changes. This simple, low cost, high frequency external proficiency testing program is highly sustainable and can be implemented in any multi-institutional group or region.

  5. Achieving high performance polymer optoelectronic devices for high efficiency, long lifetime and low fabrication cost

    Science.gov (United States)

    Huang, Jinsong

    This thesis described three types of organic optoelectronic devices: polymer light emitting diodes (PLED), polymer photovoltaic solar cell, and organic photo detector. The research in this work focuses improving their performance including device efficiency, operation lifetime simplifying fabrication process. With further understanding in PLED device physics, we come up new device operation model and improved device architecture design. This new method is closely related to understanding of the science and physics at organic/metal oxide and metal oxide/metal interface. In our new device design, both material and interface are considered in order to confine and balance all injected carriers, which has been demonstrated very be successful in increasing device efficiency. We created two world records in device efficiency: 18 lm/W for white emission fluorescence PLED, 22 lm/W for red emission phosphorescence PLED. Slow solvent drying process has been demonstrated to significantly increase device efficiency in poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl C 61-butyric acid methyl ester (PCBM) mixture polymer solar cell. From the mobility study by time of flight, the increase of efficiency can be well correlated to the improved carrier transport property due to P3HT crystallization during slow solvent drying. And it is found that, similar to PLED, balanced carrier mobility is essential in high efficient polymer solar cell. There is also a revolution in our device fabrication method. A unique device fabrication method is presented by an electronic glue based lamination process combined with interface modification as a one-step polymer solar cell fabrication process. It can completely skip the thermal evaporation process, and benefit device lifetime by several merits: no air reactive. The device obtained is metal free, semi-transparent, flexible, self-encapsulated, and comparable efficiency with that by regular method. We found the photomultiplication (PM) phenomenon in C

  6. Achieving conservation when opportunity costs are high: optimizing reserve design in Alberta's oil sands region.

    Directory of Open Access Journals (Sweden)

    Richard R Schneider

    Full Text Available Recent studies have shown that conservation gains can be achieved when the spatial distributions of biological benefits and economic costs are incorporated in the conservation planning process. Using Alberta, Canada, as a case study we apply these techniques in the context of coarse-filter reserve design. Because targets for ecosystem representation and other coarse-filter design elements are difficult to define objectively we use a trade-off analysis to systematically explore the relationship between conservation targets and economic opportunity costs. We use the Marxan conservation planning software to generate reserve designs at each level of conservation target to ensure that our quantification of conservation and economic outcomes represents the optimal allocation of resources in each case. Opportunity cost is most affected by the ecological representation target and this relationship is nonlinear. Although petroleum resources are present throughout most of Alberta, and include highly valuable oil sands deposits, our analysis indicates that over 30% of public lands could be protected while maintaining access to more than 97% of the value of the region's resources. Our case study demonstrates that optimal resource allocation can be usefully employed to support strategic decision making in the context of land-use planning, even when conservation targets are not well defined.

  7. Achieving conservation when opportunity costs are high: optimizing reserve design in Alberta's oil sands region.

    Science.gov (United States)

    Schneider, Richard R; Hauer, Grant; Farr, Dan; Adamowicz, W L; Boutin, Stan

    2011-01-01

    Recent studies have shown that conservation gains can be achieved when the spatial distributions of biological benefits and economic costs are incorporated in the conservation planning process. Using Alberta, Canada, as a case study we apply these techniques in the context of coarse-filter reserve design. Because targets for ecosystem representation and other coarse-filter design elements are difficult to define objectively we use a trade-off analysis to systematically explore the relationship between conservation targets and economic opportunity costs. We use the Marxan conservation planning software to generate reserve designs at each level of conservation target to ensure that our quantification of conservation and economic outcomes represents the optimal allocation of resources in each case. Opportunity cost is most affected by the ecological representation target and this relationship is nonlinear. Although petroleum resources are present throughout most of Alberta, and include highly valuable oil sands deposits, our analysis indicates that over 30% of public lands could be protected while maintaining access to more than 97% of the value of the region's resources. Our case study demonstrates that optimal resource allocation can be usefully employed to support strategic decision making in the context of land-use planning, even when conservation targets are not well defined.

  8. Cost-Benefit Analysis of High-Speed Rail Link between Hong Kong and Mainland China

    Directory of Open Access Journals (Sweden)

    R. Tao

    2011-07-01

    Full Text Available The Legislative Council in Hong Kong has approved a funding of USD$8.60 billion to build the high-speed rail (HSR line linking mainland China. HSR is a break-through technology that allows trains running at a speed over 250 km per hour. The most controversial part of the HSR investment is whether its cost could be compensated by the social benefits. In this study, a cost-benefit analysis of the Hong Kong to mainland HSR (HKM-HSR line is carried out. First, all the direct and indirect costs, and social benefits are defined; then, monetary equivalents are assigned to these elements; third, all the future values are discounted into present values and aggregated. The results show that the project has a positive net present value (NPV up to USD$2,068.49 million, which proves that the investment is worth. In addition, other transport alternatives, i.e. the existing roadway and conventional railway, are examined and compared with HKM-HSR, which unveils that HSR has the largest positive NPV among these three passenger transportation modes because of its excellent performance in ticket revenue, travel time savings and safety improvement.

  9. What are the costs and benefits of biodiversity recovery in a highly polluted estuary?

    Science.gov (United States)

    Pascual, M; Borja, A; Franco, J; Burdon, D; Atkins, J P; Elliott, M

    2012-01-01

    Biodiversity recovery measures have often been ignored when dealing with the restoration of degraded aquatic systems. Furthermore, biological valuation methods have been applied only spatially in previous studies, and not jointly on a temporal and spatial scale. The intense monitoring efforts carried out in a highly polluted estuary, in northern Spain (Nervión estuary), allowed for the economic valuation of the costs and the biological valuation of the benefits associated with a 21 years sewage scheme application. The analysis show that the total amount of money invested into the sewage scheme has contributed to the estuary's improvement of both environmental and biological features, as well as to an increase in the uses and services provided by the estuary. However, the inner and outer parts of the estuary showed different responses. An understanding of the costs and trajectories of the environmental recovery of degraded aquatic systems is increasingly necessary to allow policy makers and regulators to formulate robust, cost-efficient and feasible management decisions.

  10. A LOW COST AND HIGH QUALITY SOLID FUEL FROM BIOMASS AND COAL FINES

    Energy Technology Data Exchange (ETDEWEB)

    John T. Kelly; George Miller; Mehdi Namazian

    2001-07-01

    Use of biomass wastes as fuels in existing boilers would reduce greenhouse gas emissions, SO2 and NOx emissions, while beneficially utilizing wastes. However, the use of biomass has been limited by its low energy content and density, high moisture content, inconsistent configuration and decay characteristics. If biomass is upgraded by conventional methods, the cost of the fuel becomes prohibitive. Altex has identified a process, called the Altex Fuel Pellet (AFP) process, that utilizes a mixture of biomass wastes, including municipal biosolids, and some coal fines, to produce a strong, high energy content, good burning and weather resistant fuel pellet, that is lower in cost than coal. This cost benefit is primarily derived from fees that are collected for accepting municipal biosolids. Besides low cost, the process is also flexible and can incorporate several biomass materials of interest The work reported on herein showed the technical and economic feasibility of the AFP process. Low-cost sawdust wood waste and light fractions of municipal wastes were selected as key biomass wastes to be combined with biosolids and coal fines to produce AFP pellets. The process combines steps of dewatering, pellet extrusion, drying and weatherizing. Prior to pilot-scale tests, bench-scale test equipment was used to produce limited quantities of pellets for characterization. These tests showed which pellet formulations had a high potential. Pilot-scale tests then showed that extremely robust pellets could be produced that have high energy content, good density and adequate weatherability. It was concluded that these pellets could be handled, stored and transported using equipment similar to that used for coal. Tests showed that AFP pellets have a high combustion rate when burned in a stoker type systems. While NOx emissions under stoker type firing conditions was high, a simple air staging approach reduced emissions to below that for coal. In pulverized-fuel-fired tests it was

  11. System Evaluations and Life-Cycle Cost Analyses for High-Temperature Electrolysis Hydrogen Production Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Edwin A. Harvego; James E. O' Brien; Michael G. McKellar

    2012-05-01

    This report presents results of system evaluations and lifecycle cost analyses performed for several different commercial-scale high-temperature electrolysis (HTE) hydrogen production concepts. The concepts presented in this report rely on grid electricity and non-nuclear high-temperature process heat sources for the required energy inputs. The HYSYS process analysis software was used to evaluate both central plant designs for large-scale hydrogen production (50,000 kg/day or larger) and forecourt plant designs for distributed production and delivery at about 1,500 kg/day. The HYSYS software inherently ensures mass and energy balances across all components and it includes thermodynamic data for all chemical species. The optimized designs described in this report are based on analyses of process flow diagrams that included realistic representations of fluid conditions and component efficiencies and operating parameters for each of the HTE hydrogen production configurations analyzed. As with previous HTE system analyses performed at the INL, a custom electrolyzer model was incorporated into the overall process flow sheet. This electrolyzer model allows for the determination of the average Nernst potential, cell operating voltage, gas outlet temperatures, and electrolyzer efficiency for any specified inlet steam, hydrogen, and sweep-gas flow rates, current density, cell active area, and external heat loss or gain. The lifecycle cost analyses were performed using the H2A analysis methodology developed by the Department of Energy (DOE) Hydrogen Program. This methodology utilizes spreadsheet analysis tools that require detailed plant performance information (obtained from HYSYS), along with financial and cost information to calculate lifecycle costs. There are standard default sets of assumptions that the methodology uses to ensure consistency when comparing the cost of different production or plant design options. However, these assumptions may also be varied within the

  12. An fMRI study on variation of visuospatial cognitive performance of young male due to highly concentrated oxygen administration

    Science.gov (United States)

    Chung, Soon Cheol; Kim, Ik Hyeon; Tack, Gye Rae; Sohn, Jin Hun

    2004-04-01

    This study investigated the effects of 30% oxygen administration on the visuospatial cognitive performance using fMRI. Eight college students (right-handed, average age 23.5) were selected as subjects for this study. Oxygen supply equipment which gives 21% and 30% oxygen at a constant rate of 8L/min was developed for this study. To measure the performance of visuospatial cognition, two questionnaires with similar difficulty containing 20 questions each were also developed. Experiment was designed as two runs: run for visuospatial cognition test with normal air (21% of oxygen) and run for visuospatial cognition test with highly concentrated air (30% of oxygen). Run consists of 4 blocks and each block has 8 control problems and 5 visuospatial problems. Functional brain images were taken from 3T MRI using single-shot EPI method. Activities of neural network due to performing visuospatial cognition test were identified using subtraction procedure, and activation areas while performing visuospatial cognition test were extracted using double subtraction procedure. Activities were observed at occipital lobe, parietal lobe, and frontal lobe when performing visuospatial cognition test following both 21% and 30% oxygen administration. But in case of only 30% oxygen administration there were more activities at left precuneus, left cuneus, right postcentral gyrus, bilateral middle frontal gyri, right inferior frontal gyrus, left superior frontal gyrus, bilateral uvula, bilateral pyramis, and nodule compared with 21% oxygen administration. From results of visuospatial cognition test, accuracy rate increased in case of 30% oxygen administration. Thus it could be concluded that highly concentrated oxygen administration has positive effects on the visuospatial cognitive performance.

  13. The Application of High Density Electronic Packaging for Spacecraft Cost and Mass Reduction

    Science.gov (United States)

    Lowry, Lynn E.; Prokop, Jon S.; Sandborn, Peter; Evans, Kristan

    1995-01-01

    It has become clear over the past few years that packaging of spacecraft electronic systems must be improved. Not only have the weight and volume taken up by conventional packaging and interconnect systems become excessive, but active devices have advanced to the point where system performance is often limited by the packaging. Since electronic systems account for up to 30% of the size and weight budgets of a spacecraft, the utilization of high density electronic packaging will be a very important path to overall spacecraft miniaturization. In the late 1970's high density interconnection technologies were being introduced into mainframe computer applications. Subsequently, these technologies have been applied to avionics, telecommunication, biomedical and automotive systems. In each application the driving forces behind the adoption of these technologies were; improved electrical performance, miniaturization, reduced power consumption, increased reliability and reduced manufacturing costs. The application of these technologies to planetary missions could provide significant benefits by way of reduced cost and design time if commercial technology and best commercial manufacturing practices are accepted. A mixed signal telecommunication function has been used as an example to illustrate the potential mass, volume and power reduction achievable with the implementation of high density packaging technologies. The tradeoff analysis which was performed demonstrated that packaging technology selection is application specific, and system level impact must be considered early on in the design process. The results of this study which compare size, performance, cost, risk and system level impact are given. Finally, the technical and cultural obstacles which have inhibited the implementation of these technologies is discussed. Specifically, the issues of space qualified hardware and technology availability is addressed. Space qualification is perceived by industry as being the

  14. Standard semiconductor packaging for high-reliability low-cost MEMS applications

    Science.gov (United States)

    Harney, Kieran P.

    2005-01-01

    Microelectronic packaging technology has evolved over the years in response to the needs of IC technology. The fundamental purpose of the package is to provide protection for the silicon chip and to provide electrical connection to the circuit board. Major change has been witnessed in packaging and today wafer level packaging technology has further revolutionized the industry. MEMS (Micro Electro Mechanical Systems) technology has created new challenges for packaging that do not exist in standard ICs. However, the fundamental objective of MEMS packaging is the same as traditional ICs, the low cost and reliable presentation of the MEMS chip to the next level interconnect. Inertial MEMS is one of the best examples of the successful commercialization of MEMS technology. The adoption of MEMS accelerometers for automotive airbag applications has created a high volume market that demands the highest reliability at low cost. The suppliers to these markets have responded by exploiting standard semiconductor packaging infrastructures. However, there are special packaging needs for MEMS that cannot be ignored. New applications for inertial MEMS devices are emerging in the consumer space that adds the imperative of small size to the need for reliability and low cost. These trends are not unique to MEMS accelerometers. For any MEMS technology to be successful the packaging must provide the basic reliability and interconnection functions, adding the least possible cost to the product. This paper will discuss the evolution of MEMS packaging in the accelerometer industry and identify the main issues that needed to be addressed to enable the successful commercialization of the technology in the automotive and consumer markets.

  15. Low-cost, High Flexibility I-V Curve Tracer for Photovoltaic Modules

    DEFF Research Database (Denmark)

    Ibirriaga, Julen Joseba Maestro; Pena, Xabier Miquelez de Mendiluce; Opritescu, Adrian

    2010-01-01

    This work presents the design, construction and test of an in-door low cost, high flexibility I-V curve tracer for photovoltaic modules. The tracer is connected to a Xenon lamp based flashing solar simulator. The designed tracer is able to deal with the very fast changing irradiation conditions...... and its control software offers the flexibility to automatically adapt to the different irradiation conditions set by the flashing solar simulator. Simulation and experimental tests have been carried out, in order to verify the behaviour and performance of the designed I-V curve tracer....

  16. [High-cost therapy. Ethical principles of allocation of scarce resources].

    Science.gov (United States)

    Norheim, O F

    1992-10-10

    This article raises some ethical problems concerning high-cost therapy for malignant haematological diseases. The problem of setting priorities is discussed within the framework of utilitarianism, right-based theories and the contractarian theory of John Rawls. It is argued that utilitarianism can provide precise answers, based on the principle of allocative efficiency. However, this is not the only objective of a public health care system. The right-based approach is discussed, but sufficiently precise definitions seem hard to formulate. The contractarian approach is regarded as interesting, since it tries to address the question of trade-offs between objectives of allocative efficiency and distributive fairness.

  17. The burden of responsibility: Interpersonal costs of high self-control.

    Science.gov (United States)

    Koval, Christy Zhou; vanDellen, Michelle R; Fitzsimons, Gráinne M; Ranby, Krista W

    2015-05-01

    The psychological literature on self-control has illustrated the many benefits experienced by people with high self-control, who are more successful both personally and interpersonally. In the current research, we explore the possibility that having high self-control also may have some interpersonal costs, leading individuals to become burdened by others' reliance. In Studies 1 and 2, we examined the effects of actors' self-control on observers' performance expectations and found that observers had higher performance expectations for actors with high (vs. low) self-control. In Study 3, we tested the effect of actors' self-control on work assigned to actors and found that observers assigned greater workloads to actors with high (vs. low) self-control. In Study 4, we examined how actors and observers differed in their assessments of the effort expended by high and low self-control actors and found that observers (but not actors) reported that high self-control actors expended less effort than low self-control actors. Finally, we found that people high (vs. low) in self-control reported greater burden from the reliance of coworkers (Study 5) and romantic partners (Study 6), and this tendency led them to feel less satisfied with their relationships (Study 6). Together, results from these studies provide novel evidence that individuals' self-control affects others' attitudes and behaviors toward them, and suggest that these interpersonal dynamics can have negative consequences for high self-control individuals.

  18. Estimating Total Program Cost of a Long-Term, High-Technology, High-Risk Project with Task Durations and Costs That May Increase Over Time

    National Research Council Canada - National Science Library

    Brown, Gerald G; Grose, Roger T; Koyak, Robert A

    2006-01-01

    .... Each task in the project can begin only when all its predecessor tasks have been completed, and each task has a range of feasible durations with a month-by-month cost profile for each duration...

  19. A Case of Type 2 Amiodarone-Induced Thyrotoxicosis That Underwent Total Thyroidectomy under High-Dose Steroid Administration

    Directory of Open Access Journals (Sweden)

    Koshi Hashimoto

    2015-01-01

    Full Text Available Amiodarone is used commonly and effectively in the treatment of arrhythmia; however, it may cause thyrotoxicosis categorized into two types: iodine-induced hyperthyroidism (type 1 amiodarone-induced thyrotoxicosis (AIT and destructive thyroiditis (type 2 AIT. We experienced a case of type 2 AIT, in which high-dose steroid was administered intravenously, and we finally decided to perform total thyroidectomy, resulting in a complete cure of the AIT. Even though steroid had been administered to the patient (maximum 80 mg of prednisolone, the operation was performed safely and no acute adrenal crisis as steroid withdrawal syndrome was found after the operation. Few cases of type 2 AIT that underwent total thyroidectomy with high-dose steroid administration have been reported. The current case suggests that total thyroidectomy should be taken into consideration for patients with AIT who cannot be controlled by medical treatment and even in those under high-dose steroid administration.

  20. Building America Top Innovations 2012: High-Performance Home Cost Performance Trade-offs: Production Builders

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-01-01

    This Building America Top Innovations profile describes Building America research showing how some energy-efficiency measure cost increases can balance against measures that reduce up-front costs: Advanced framing cuts lumber costs, right sizing can mean downsizing the HVAC, moving HVAC into conditioned space cuts installation costs, designing on a 2-foot grid reduces materials waste, etc.

  1. Low-Cost High-Concentration Photovoltaic Systems for Utility Power Generation

    Energy Technology Data Exchange (ETDEWEB)

    McConnell, R.; Garboushian, V.; Gordon, R.; Dutra, D.; Kinsey, G.; Geer, S.; Gomez, H.; Cameron, C.

    2012-03-31

    Under DOE's Technology Pathway Partnership (TPP) program, Amonix, Inc. developed a new generation of high-concentration photovoltaic systems using multijunction technology and established the manufacturing capacity needed to supply multi-megawatt power plants buing using the new Amonix 7700-series solar energy systems. For this effort, Amonix Collaborated with a variety of suppliers and partners to complete project tasks. Subcontractors included: Evonik/Cyro; Hitek; the National Renewable Energy Laboratory (NREL); Raytech; Spectrolab; UL; University of Nevada, Las Vegas; and TUV Rheinland PTL. The Amonix TPP tasks included: Task 1: Multijunction Cell Optimization for Field Operation, Task 2: Fresnel Lens R&D, Task 3: Cell Package Design & Production, Task 4: Standards Compliance and Reliability Testing, Task 5: Receiver Plate Production, Task 6: MegaModule Performance, Task 7: MegaModule Cost Reduction, Task 8: Factory Setup and MegaModule Production, Task 9: Tracker and Tracking Controller, Task 10: Installation and Balance of System (BOS), Task 11: Field Testing, and Task 12: Solar Advisor Modeling and Market Analysis. Amonix's TPP addressed nearly the complete PV value chain from epitaxial layer design and wafer processing through system design, manufacturing, deployment and O&M. Amonix has made progress toward achieving these reduced costs through the development of its 28%+ efficient MegaModule, reduced manufacturing and installation cost through design for manufacturing and assembly, automated manufacturing processes, and reduced O&M costs. Program highlights include: (1) Optimized multijunction cell and cell package design to improve performance by > 10%; (2) Updated lens design provided 7% increased performance and higher concentration; (3) 28.7% DC STC MegaModule efficiency achieved in Phase II exceeded Phase III performance goal; (4) New 16' focal length MegaModule achieved target materials and manufacturing cost reduction; (5) Designed and

  2. Development of Manufacturing Methods for Low-Cost, High-Temperature Sensors Applicable to Hypersonic Research Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Routine installation and use of high-temperature optical sensors for characterization of advanced materials critical to NASA hypersonic programs are difficult due to...

  3. Low-Cost, High-Performance Combustion Chamber for LOX/CH4 Propulsion, Phase II Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this project, Ultramet is designing and fabricating a lightweight, high temperature combustion chamber for use with cryogenic liquid oxygen/methane (LOX/CH4)...

  4. A scalable-low cost architecture for high gain beamforming antennas

    KAUST Repository

    Bakr, Omar

    2010-10-01

    Many state-of-the-art wireless systems, such as long distance mesh networks and high bandwidth networks using mm-wave frequencies, require high gain antennas to overcome adverse channel conditions. These networks could be greatly aided by adaptive beamforming antenna arrays, which can significantly simplify the installation and maintenance costs (e.g., by enabling automatic beam alignment). However, building large, low cost beamforming arrays is very complicated. In this paper, we examine the main challenges presented by large arrays, starting from electromagnetic and antenna design and proceeding to the signal processing and algorithms domain. We propose 3-dimensional antenna structures and hybrid RF/digital radio architectures that can significantly reduce the complexity and improve the power efficiency of adaptive array systems. We also present signal processing techniques based on adaptive filtering methods that enhance the robustness of these architectures. Finally, we present computationally efficient vector quantization techniques that significantly improve the interference cancellation capabilities of analog beamforming architectures. © 2010 IEEE.

  5. A High-Efficiency, Low-Cost Solution for On-Board Power Converters

    Directory of Open Access Journals (Sweden)

    V. Boscaino

    2012-01-01

    Full Text Available Wide-input, low-voltage, and high-current applications are addressed. A single-ended isolated topology which improves the power efficiency, reduces both switching and conduction losses, and heavily lowers the system cost is presented. During each switching cycle, the transformer core reset is provided. The traditional tradeoff between the maximum allowable duty-cycle and the reset voltage is avoided and the off-voltage of active switches is clamped to the input voltage. Therefore, the system cost is heavily reduced and the converter is well suited for wide-input applications. Zero-voltage switching is achieved for active switches, and the power efficiency is greatly improved. In the output mesh, an inductor is included making the converter suitable for high-current, low-voltage applications. Since the active clamp forward converter is the closest competitor of the proposed converter, a comparison is provided as well. In this paper, the steady-state and small-signal analysis of the proposed converter is presented. Design examples are provided for further applications. Simulation and experimental results are shown to validate the great advantages brought by the proposed topology.

  6. Direct costs and benefits of multiple mating: Are high female mating rates due to ejaculate replenishment?

    Science.gov (United States)

    Worthington, Amy M; Kelly, Clint D

    2016-03-01

    Females often mate more than is necessary to ensure reproductive success even when they incur significant costs from doing so. Direct benefits are hypothesized to be the driving force of high female mating rates, yet species in which females only receive an ejaculate from their mate still realize increased fitness from multiple mating. Using the Texas field cricket, Gryllus texensis, we experimentally test the hypothesis that multiple mating via monandry or polyandry increases female fitness by replenishing ejaculates, thereby allowing females to produce more offspring for a longer period of time. We found that higher rates of female mating significantly increased lifetime fecundity and oviposition independent of whether females mated with one or two males. Further, although interactions with males significantly increased rates of injury or death, females that replenished ejaculates experienced an increased rate and duration of oviposition, demonstrating that the immediate benefits of multiple mating may greatly outweigh the long-term costs that mating poses to female condition and survival. We suggest that ejaculate replenishment is a driving factor of high mating rates in females that do not receive external direct benefits from mating and that a comparative study across taxa will provide additional insight into the role that ejaculate size plays in the evolution of female mating rates.

  7. High efficiency and low cost preparation of size controlled starch nanoparticles through ultrasonic treatment and precipitation.

    Science.gov (United States)

    Chang, Yanjiao; Yan, Xiaoxia; Wang, Qian; Ren, Lili; Tong, Jin; Zhou, Jiang

    2017-07-15

    The purpose of this work was to develop an approach to produce size controlled starch nanoparticles (SNPs), via precipitation with high efficiency and low cost. High concentration starch aqueous pastes (up to 5wt.%) were treated by ultrasound. Viscosity measurements and size exclusion chromatography characterization revealed that, after 30min ultrasonic treatment, viscosity of the starch pastes decreased two orders of magnitude and the weight average molecular weight of the starch decreased from 8.4×10(7) to 2.7×10(6)g/mol. Dynamic light scattering measurements and scanning electron microscopy observations showed that the SNPs prepared from the starch pastes with ultrasonic treatments were smaller (∼75nm) and more uniform. Moreover, SNPs could be obtained using less non-solvents. X-ray diffraction results indicated that effect of the ultrasonic treatment on crystalline structure of the SNPs was negligible. Ultrasound can be utilized to prepare smaller SNPs through nanoprecipitation with higher efficiency and lower cost. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. IMPACT OF HEALTH TECHNOLOGY ASSESSMENT IN LITIGATION CONCERNING ACCESS TO HIGH-COST DRUGS.

    Science.gov (United States)

    Aleman, Alicia; Perez Galan, Ana

    2017-07-31

    The impact of health technology assessment (HTA) in the judicialization of the right of health has not been deeply studied in Latin American countries. The purpose of this study is to review the process of judicialization of the access to high cost drugs in Uruguay and assess the impact HTAs have had on this process. The methodology used for this study included a comprehensive literature search in electronic databases, local journals, internal documents developed in the Ministry of Health, as well as conducting interviews with key informants. Judicialization of the access of high cost drugs has been increasing since 2010. The strategy of the Ministry of Health of Uruguay to decrease this problem included the organization of roundtables with judges and other stakeholders on the basis of HTA, the training of defense lawyers in the use and interpretation of HTA, and the participation of a professional who develops HTA in the preparation of the defense arguments. A year after the implementation of this strategy, 25 percent of writs of protection were won by the Ministry of Health. Even though the strategy implemented was effective in reducing the loss of litigations, it was not effective in reducing the growing number of writs of protection. It is essential to address this problem in a broad debate and to promote understanding between the parties.

  9. Drug costs and benefits of medical treatments in high-unmet need solid tumours in the Nordic countries

    DEFF Research Database (Denmark)

    Osterlund, P; Sorbye, H; Pfeiffer, P.

    2016-01-01

    Introduction: Regional and hospital decision-makers increasingly require analyses assessing the cost benefit profile of new cancer drugs. This analysis evaluates the cost-benefit profile of nano albumin-bound paclitaxel (nab-paclitaxel) in pancreatic cancer, versus other drugs indicated in high-u...

  10. Investigation of a Solution-Processable, Nonspecific Surface Modifier for Low Cost, High Work Function Electrodes.

    Science.gov (United States)

    Hinckley, Allison C; Wang, Congcong; Pfattner, Raphael; Kong, Desheng; Zhou, Yan; Ecker, Ben; Gao, Yongli; Bao, Zhenan

    2016-08-03

    We demonstrate the ability of the highly fluorinated, chemically inert copolymer poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) to significantly increase the work function of a variety of common electrode materials. The work function change is hypothesized to occur via physisorption of the polymer layer and formation of a surface dipole at the polymer/conductor interface. When incorporated into organic solar cells, an interlayer of PVDF-HFP at an Ag anode increases the open circuit voltage by 0.4 eV and improves device power conversion efficiency by approximately an order of magnitude relative to Ag alone. Solution-processable in air, PVDF-HFP thin films provide one possible route toward achieving low cost, nonreactive, high work function electrodes.

  11. Segmentation of low‐cost high efficiency oxide‐based thermoelectric materials

    DEFF Research Database (Denmark)

    Le, Thanh Hung; Van Nong, Ngo; Linderoth, Søren;

    2015-01-01

    efficiency of TE oxides has been a major drawback limiting these materials to broaden applications. In this work, theoretical calculations are used to predict how segmentation of oxide and semimetal materials, utilizing the benefits of both types of materials, can provide high efficiency, high temperature...... segmented legs based p-type Ca3Co4O9 and n-type ZnO oxides excluding electrical and thermal losses. It is found that the maximum efficiency of segmented unicouple could be linearly decreased with increasing the interfacial contact resistance. The obtained results provide useful tool for designing a low...... oxide-based segmented legs. The materials for segmentation are selected by their compatibility factors and their conversion efficiency versus material cost, i.e., “efficiency ratio”. Numerical modelling results showed that conversion efficiency could reach values of more than 10% for unicouples using...

  12. A low-cost sensor for high density urban CO2 monitoring

    Science.gov (United States)

    Zeng, N.; Martin, C.

    2015-12-01

    The high spatial-termporal variability of greenhouse gases and other pollution sources in an urban environment can not be easily resolved with current high-accuracy but expensive instruments. We have tested a small, low-cost NDIR CO2 sensor designed for potential use. It has a manufacturer's specified accuracy of +- 30 parts per million (ppm). However, initial results running parallel with a research-grade greenhouse gas analyzer have shown that the absolute accuracy of the sensor is within +-5ppm, suggesting their utility for sensing ambient air variations in carbon dioxide. Through a multivariate analysis, we have determined a correction procedure that when accounting for environmental temperature, humidity, air pressure, and the device's span and offset, we can further increase the accuracy of the collected data. We will show results from rooftop measurements over a period of one year and CO2 tracking data in the Washington-Baltimore Metropolitan area.

  13. Toward Low-Cost Highly Portable Tactile Displays with Shape Memory Alloys

    Directory of Open Access Journals (Sweden)

    R. Velázquez

    2007-01-01

    Full Text Available This paper presents a new concept of low-cost, high-resolution, lightweight, compact and highly portable tactile display. The prototype consists of an array of 8 × 8 upward/downward independent moveable pins based on shape memory alloy (SMA technology. Each tactile actuator consists of an antagonist arranged pair of miniature NiTi SMA helical springs capable of developing a 300 mN pull force at 1.5 Hz bandwidth by using simple forced-air convection. The proposed concept allows the development of 200 g weight tactile instruments of compact dimensions which can be easily carried by a visually disabled user. A detailed technical description of the SMA active element, tactile actuator and tactile display is presented and discussed. Preliminary perceptual results confirm the effectiveness of the display on information transmission.

  14. Next Generation Astronomical X-ray Optics: High Angular Resolution, Light Weight, and Low Production Cost

    Science.gov (United States)

    Zhang. W. W.; Biskach, M. P.; Blake, P. N.; Chan, K. W.; Gaskin, J. A.; Hong, M. L.; Jones, W. D.; Kolos, L. D.; Mazzarella, J. R.; McClelland, R. S.; O'Dell, S. L.; Saha, T. T.; Sharpe, M. V.

    2012-01-01

    X-ray astronomy depends on the availability of telescopes with high resolution and large photon collecting areas. Since x-ray observation can only be carried out above the atmosphere, these telescopes must be necessarily lightweight. Compounding the lightweight requirement is that an x-ray telescope consists of many nested concentric shells, which further require that x-ray mirrors must also be geometrically thin to achieve high packing efficiency. This double lightweight and geometrically thin requirement poses significant technical challenges in fabricating the mirrors and in integrating them into mirror assemblies. This paper reports on the approach, strategy and status of our x-ray optics development program whose objective is to meet these technical challenges at modest cost to enable future x-ray missions, including small Explorer missions in the near term, probe class missions in the medium term, and large flagship missions in the long term.

  15. Analysis on Administration Cost of County Government Taking a County in Chongqing as an Example%县级政府行政成本探析——以重庆市X县为例

    Institute of Scientific and Technical Information of China (English)

    曹欢

    2011-01-01

    The current situation of county government's administration cost is analyzed in theory and demonstration. A county in Chongqing is taken as an example. The virtual reasons of excessive administration cost of county government are revealed, and the command policy is proposed.%以重庆市X县为例,对县级政府行政成本的现状进行了实证分析与理论分析,剖析了县级政府行政成本高位运行的实质原因,提出控制县级政府行政成本的政策建议。

  16. Low Cost High-H2 Syngas Production for Power and Liquid Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, S. James [Gas Technology Inst., Des Plaines, IL (United States)

    2015-07-31

    This report summarizes the technical progress made of the research project entitled “Low Cost High-H2 Syngas Production for Power and Liquid Fuels,” under DOE Contract No. DE-FE-0011958. The period of performance was October 1, 2013 through July 30, 2015. The overall objectives of this project was to determine the technical and economic feasibility of a systems approach for producing high hydrogen syngas from coal with the potential to reduce significantly the cost of producing power, chemical-grade hydrogen or liquid fuels, with carbon capture to reduce the environmental impact of gasification. The project encompasses several areas of study and the results are summarized here. (1) Experimental work to determine the technical feasibility of a novel hybrid polymer/metal H2-membrane to recover pure H2 from a coal-derived syngas was done. This task was not successful. Membranes were synthesized and show impermeability of any gases at required conditions. The cause of this impermeability was most likely due to the densification of the porous polymer membrane support made from polybenzimidazole (PBI) at test temperatures above 250 °C. (2) Bench-scale experimental work was performed to extend GTI's current database on the University of California Sulfur Recovery Process-High Pressure (UCSRP-HP) and recently renamed Sulfur Removal and Recovery (SR2) process for syngas cleanup including removal of sulfur and other trace contaminants, such as, chlorides and ammonia. The SR2 process tests show >90% H2S conversion with outlet H2S concentrations less than 4 ppmv, and 80-90% ammonia and chloride removal with high mass transfer rates. (3) Techno-economic analyses (TEA) were done for the production of electric power, chemical-grade hydrogen and diesel fuels, from a mixture of coal- plus natural gas-derived syngas using the Aerojet Rocketdyne (AR) Advanced Compact coal gasifier and a natural gas partial oxidation reactor (POX) with SR2 technology. Due to the unsuccessful

  17. Aliskiren administration during early postnatal life sex-specifically alleviates hypertension programmed by maternal high fructose consumption

    Directory of Open Access Journals (Sweden)

    You-Lin Tain

    2016-07-01

    Full Text Available Background: Maternal high fructose (HF intake induced renal programming and hypertension in male adult offspring. We examined whether maternal HF intake causes programmed hypertension and whether aliskiren administration confers protection against the process in a sex-specific manner, with a focus on the transcriptome changes in the kidney using next-generation RNA sequencing (NGS technology and renin-angiotensin system (RAS. Methods: Pregnant Sprague–Dawley rats received regular chow or chow supplemented with 60% fructose throughout pregnancy and lactation. Offspring were assigned to six groups: male control, male HF (MHF, MHF+Aliskiren, female control, female HF (FHF, and FHF+Aliskiren. Oral aliskiren 10 mg/kg/day was administered via gastric gavage between 2–4 weeks of age. Rats were sacrificed at 12 weeks of age. Results: Maternal HF intake induced programmed hypertension in 12-week-old offspring of both sexes. HF regulated renal transcriptome and RAS components in the offspring kidney in a sex-specific manner. Aliskiren administration prevented HF-induced programmed hypertension in both sexes of adult offspring. Aliskiren administration increased ACE2 and MAS protein levels in female kidneys exposed to maternal HF intake. Conclusion: Maternal HF induced programmed hypertension in both sexes of adult offspring, which was sex-specifically mitigated by early aliskiren administration. Better understanding of the sex-dependent mechanisms that underlie maternal HF-induced renal programming will help develop a novel sex-specific strategy to prevent programmed hypertension.

  18. Whole-patient measure of safety: using administrative data to assess the probability of highly undesirable events during hospitalization.

    Science.gov (United States)

    Perla, Rocco J; Hohmann, Samuel F; Annis, Karen

    2013-01-01

    Hospitals often have limited ability to obtain primary clinical data from electronic health records to use in assessing quality and safety. We outline a new model that uses administrative data to gauge the safety of care at the hospital level. The model is based on a set of highly undesirable events (HUEs) defined using administrative data and can be customized to address the priorities and needs of different users. Patients with HUEs were identified using discharge abstracts from July 1, 2008 through June 30, 2010. Diagnoses were classified as HUEs based on the associated present-on-admission status. The 2-year study population comprised more than 6.5 million discharges from 161 hospitals. The proportion of hospitalizations including at least one HUE during the 24-month study period varied greatly among hospitals, with a mean of 7.74% (SD 2.3%) and a range of 13.32% (max, 15.31%; min, 1.99%). The whole-patient measure of safety provides a global measure to use in assessing hospitals with the patient's entire care experience in mind. As administrative and clinical datasets become more consistent, it becomes possible to use administrative data to compare the rates of HUEs across organizations and to identify opportunities for improvement.

  19. Incremental health care costs for chronic pain in Ontario, Canada: a population-based matched cohort study of adolescents and adults using administrative data.

    Science.gov (United States)

    Hogan, Mary-Ellen; Taddio, Anna; Katz, Joel; Shah, Vibhuti; Krahn, Murray

    2016-08-01

    Little is known about the economic burden of chronic pain and how chronic pain affects health care utilization. We aimed to estimate the annual per-person incremental medical cost and health care utilization for chronic pain in the Ontario population from the perspective of the public payer. We performed a retrospective cohort study using Ontario health care databases and the electronically linked Canadian Community Health Survey (CCHS) from 2000 to 2011. We identified subjects aged ≥12 years from the CCHS with chronic pain and closely matched them to individuals without pain using propensity score matching methods. We used linked data to determine mean 1-year per-person health care costs and utilization for each group and mean incremental cost for chronic pain. All costs are reported in 2014 Canadian dollars. After matching, we had 19,138 pairs of CCHS respondents with and without chronic pain. The average age was 55 years (SD = 18) and 61% were female. The incremental cost to manage chronic pain was $1742 per person (95% confidence interval [CI], $1488-$2020), 51% more than the control group. The largest contributor to the incremental cost was hospitalization ($514; 95% CI, $364-$683). Incremental costs were the highest in those with severe pain ($3960; 95% CI, $3186-$4680) and in those with most activity limitation ($4365; 95% CI, $3631-$5147). The per-person cost to manage chronic pain is substantial and more than 50% higher than a comparable patient without chronic pain. Costs are higher in people with more severe pain and activity limitations.

  20. Development of the technical leadership skills scale in vocational and technical high school administrators: Reliability and validity studies

    Directory of Open Access Journals (Sweden)

    Gökçe ÖZDEMİR

    2016-04-01

    Full Text Available The aim of this study is to develop a scale for the determination technical leadership skills of vocational and technical high school administrators. For the study, the sample was comprised of a total of 236 vocational education teachers working at nine out of 22 technical and vocational high schools located in the Şahinbey and Şehitkamil districts of Gaziantep Province. The criteria for sample selection were twofold: (1 The selected schools are the longest established in the districts, and (2 the participant teachers had been working with the same school administrators at these schools for at least one year. Exploratory Factor Analysis (EFA and Confirmatory Factor Analysis (CFA were performed by the researcher in order to determine the construct validity of the scale. EFA results indicated that the scale had three sub-dimensions. The sub-dimensions were “Pedagogical and Social Skills”, “Managerial Skills”, and “Professional Skills”. The final form of the scale consisted of 40 items. Internal consistency coefficients of the scores taken from the sub-dimensions varied between .94 and .95. Research results concluded that the Technical Leadership Skills Scale (TLSS is a valid and reliable measurement instrument to determine technical leadership skills of vocational and technical high school administrators.

  1. Advanced Insulation for High Performance Cost-Effective Wall, Roof, and Foundation Systems Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Costeux, Stephane [Dow Chemical Company, Midland, MI (United States); Bunker, Shanon [Dow Chemical Company, Midland, MI (United States)

    2013-12-20

    The objective of this project was to explore and potentially develop high performing insulation with increased R/inch and low impact on climate change that would help design highly insulating building envelope systems with more durable performance and lower overall system cost than envelopes with equivalent performance made with materials available today. The proposed technical approach relied on insulation foams with nanoscale pores (about 100 nm in size) in which heat transfer will be decreased. Through the development of new foaming methods, of new polymer formulations and new analytical techniques, and by advancing the understanding of how cells nucleate, expand and stabilize at the nanoscale, Dow successfully invented and developed methods to produce foams with 100 nm cells and 80% porosity by batch foaming at the laboratory scale. Measurements of the gas conductivity on small nanofoam specimen confirmed quantitatively the benefit of nanoscale cells (Knudsen effect) to increase insulation value, which was the key technical hypotheses of the program. In order to bring this technology closer to a viable semi-continuous/continuous process, the project team modified an existing continuous extrusion foaming process as well as designed and built a custom system to produce 6" x 6" foam panels. Dow demonstrated for the first time that nanofoams can be produced in a both processes. However, due to technical delays, foam characteristics achieved so far fall short of the 100 nm target set for optimal insulation foams. In parallel with the technology development, effort was directed to the determination of most promising applications for nanocellular insulation foam. Voice of Customer (VOC) exercise confirmed that demand for high-R value product will rise due to building code increased requirements in the near future, but that acceptance for novel products by building industry may be slow. Partnerships with green builders, initial launches in smaller markets (e.g. EIFS

  2. Foraging behavior of humpback whales: kinematic and respiratory patterns suggest a high cost for a lunge.

    Science.gov (United States)

    Goldbogen, Jeremy A; Calambokidis, John; Croll, Donald A; Harvey, James T; Newton, Kelly M; Oleson, Erin M; Schorr, Greg; Shadwick, Robert E

    2008-12-01

    Lunge feeding in rorqual whales is a drag-based feeding mechanism that is thought to entail a high energetic cost and consequently limit the maximum dive time of these extraordinarily large predators. Although the kinematics of lunge feeding in fin whales supports this hypothesis, it is unclear whether respiratory compensation occurs as a consequence of lunge-feeding activity. We used high-resolution digital tags on foraging humpback whales (Megaptera novaengliae) to determine the number of lunges executed per dive as well as respiratory frequency between dives. Data from two whales are reported, which together performed 58 foraging dives and 451 lunges. During one study, we tracked one tagged whale for approximately 2 h and examined the spatial distribution of prey using a digital echosounder. These data were integrated with the dive profile to reveal that lunges are directed toward the upper boundary of dense krill aggregations. Foraging dives were characterized by a gliding descent, up to 15 lunges at depth, and an ascent powered by steady swimming. Longer dives were required to perform more lunges at depth and these extended apneas were followed by an increase in the number of breaths taken after a dive. Maximum dive durations during foraging were approximately half of those previously reported for singing (i.e. non-feeding) humpback whales. At the highest lunge frequencies (10 to 15 lunges per dive), respiratory rate was at least threefold higher than that of singing humpback whales that underwent a similar degree of apnea. These data suggest that the high energetic cost associated with lunge feeding in blue and fin whales also occurs in intermediate sized rorquals.

  3. One step lithography-less silicon nanomanufacturing for low cost high-efficiency solar cell production

    Science.gov (United States)

    Chen, Yi; Liu, Logan

    2014-03-01

    To improve light absorption, previously various antireflection material layers were created on solar wafer surface including multilayer dielectric film, nanoparticle sludges, microtextures, noble metal plasmonic nanoparticles and 3D silicon nanostructure arrays. All of these approaches involve nanoscale prepatterning, surface-area-sensitive assembly processes or extreme fabrication conditions; therefore, they are often limited by the associated high cost and low yield as well as the consequent industry incompatibility. In comparison, our nanomanufacturing, an unique synchronized and simultaneous top-down and bottom-up nanofabrication approach called simultaneous plasma enhanced reactive ion synthesis and etching (SPERISE), offers a better antireflection solution along with the potential to increase p-n junction surface area. High density and high aspect ratio anechoic nanocone arrays are repeatedly and reliably created on the entire surface of single and poly crystalline silicon wafers as well as amorphous silicon thin films within 5 minutes under room temperature. The nanocone surface had lower than 5% reflection over the entire solar spectrum and a desirable omnidirectional absorption property. Using the nanotextured solar wafer, a 156mm × 156mm 18.1%-efficient black silicon solar cell was fabricated, which was an 18.3% enhancement over the cell fabricated by standard industrial processes. This process also reduces silicon loss during the texturing step and enables tighter process control by creating more uniform surface structures. Considering all the above advantages, the demonstrated nanomanufacturing process can be readily translated into current industrial silicon solar cell fabrication lines to replace the costly and ineffective wet chemical texturing and antireflective coatings.

  4. A Highly Reliable and Cost-Efficient Multi-Sensor System for Land Vehicle Positioning

    Directory of Open Access Journals (Sweden)

    Xu Li

    2016-05-01

    Full Text Available In this paper, we propose a novel positioning solution for land vehicles which is highly reliable and cost-efficient. The proposed positioning system fuses information from the MEMS-based reduced inertial sensor system (RISS which consists of one vertical gyroscope and two horizontal accelerometers, low-cost GPS, and supplementary sensors and sources. First, pitch and roll angle are accurately estimated based on a vehicle kinematic model. Meanwhile, the negative effect of the uncertain nonlinear drift of MEMS inertial sensors is eliminated by an H∞ filter. Further, a distributed-dual-H∞ filtering (DDHF mechanism is adopted to address the uncertain nonlinear drift of the MEMS-RISS and make full use of the supplementary sensors and sources. The DDHF is composed of a main H∞ filter (MHF and an auxiliary H∞ filter (AHF. Finally, a generalized regression neural network (GRNN module with good approximation capability is specially designed for the MEMS-RISS. A hybrid methodology which combines the GRNN module and the AHF is utilized to compensate for RISS position errors during GPS outages. To verify the effectiveness of the proposed solution, road-test experiments with various scenarios were performed. The experimental results illustrate that the proposed system can achieve accurate and reliable positioning for land vehicles.

  5. A Highly Reliable and Cost-Efficient Multi-Sensor System for Land Vehicle Positioning.

    Science.gov (United States)

    Li, Xu; Xu, Qimin; Li, Bin; Song, Xianghui

    2016-05-25

    In this paper, we propose a novel positioning solution for land vehicles which is highly reliable and cost-efficient. The proposed positioning system fuses information from the MEMS-based reduced inertial sensor system (RISS) which consists of one vertical gyroscope and two horizontal accelerometers, low-cost GPS, and supplementary sensors and sources. First, pitch and roll angle are accurately estimated based on a vehicle kinematic model. Meanwhile, the negative effect of the uncertain nonlinear drift of MEMS inertial sensors is eliminated by an H∞ filter. Further, a distributed-dual-H∞ filtering (DDHF) mechanism is adopted to address the uncertain nonlinear drift of the MEMS-RISS and make full use of the supplementary sensors and sources. The DDHF is composed of a main H∞ filter (MHF) and an auxiliary H∞ filter (AHF). Finally, a generalized regression neural network (GRNN) module with good approximation capability is specially designed for the MEMS-RISS. A hybrid methodology which combines the GRNN module and the AHF is utilized to compensate for RISS position errors during GPS outages. To verify the effectiveness of the proposed solution, road-test experiments with various scenarios were performed. The experimental results illustrate that the proposed system can achieve accurate and reliable positioning for land vehicles.

  6. Case studies: low cost, high-strength, large carbon foam tooling

    Energy Technology Data Exchange (ETDEWEB)

    Lucas, R.; Danford, H. [Touchstone Research Laboratory Ltd., Triadelphia, WV (USA)

    2009-01-15

    A new carbon foam tooling system has been developed that results in a low-cost, high-strength material that has been proving attractive for creation of tooling for composite parts. Composites are stronger; lighter and less subject to corrosion and fatigue than materials that are currently used for fabrication of advanced structures. Tools to manufacture these composite parts must be rigid, durable and able to offer a coefficient of thermal expansion (CTE) closely matching that of the composites. Current technology makes it difficult to match the CTE of a composite part in the curing cycle with anything other than a carbon composite or a nickel iron alloy such as Invar. Fabrication of metallic tooling requires many, expensive stages of long duration with a large infrastructure investment. Card ban fiber reinforced polymer resin composite tooling has a shorter lead-time but limited production use because of durability concerns. Coal-based carbon foam material has a compatible CTE and strong durability, that make it an attractive alternative for use in tooling. The use of coal-based carbon foam in tooling for carbon composites is advantageous because of its low cost, light weight, machinability , vacuum integrity and compatibility with a wide range of curing processes. Large-scale tooling case studies will be presented detailing carbon foam's potential for tooling applications.

  7. Are high labour costs destroying the competitiveness of danish dairy farmers?

    DEFF Research Database (Denmark)

    Asmild, Mette; Nielsen, Kurt; Bogetoft, Peter

    This paper analysis the competitiveness of Danish dairy farmers relative to dairy farmers in other Northern European countries. We use individual farm accounts data from the European Commission’s Farm Accountancy Data Network (FADN) and have an average of 1665 observations per year in the period......¿erences in average e¿ciencies between countries. The results shows that the Danish dairy farmers, on average, were the most economically e¿cient in Northern Europe in 2007 and 2008. We ¿nd that the e¿ect of labour costs for the Danish dairy farmers is decreasing during the study period despite of the salary di......¿erences increasing. In 2002 the negative impact of having the highest hourly pay was an average 4.7 percentage points whereas it in 2008 was only 0.6 percentage 1points.This indicates that the Danish dairy farmers have been highly successful in adapting to having the highest, and increasing, hourly labour costs...

  8. Binder-free highly conductive graphene laminate for low cost printed radio frequency applications

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Xianjun; Leng, Ting; Zhang, Xiao; Hu, Zhirun, E-mail: Z.Hu@manchester.ac.uk [School of Electrical and Electronic Engineering, University of Manchester, Manchester (United Kingdom); Chen, Jia Cing; Chang, Kuo Hsin [BGT Materials Limited, Photon Science Institute, University of Manchester, Manchester M13 9PL (United Kingdom); Geim, Andre K. [Manchester Centre for Mesoscience and Nanotechnology, University of Manchester, Manchester (United Kingdom); Novoselov, Kostya S. [School of Physics and Astronomy, University of Manchester, Manchester (United Kingdom)

    2015-05-18

    In this paper, we demonstrate realization of printable radio frequency identification (RFID) antenna by low temperature processing of graphene ink. The required ultra-low resistance is achieved by rolling compression of binder-free graphene laminate. With compression, the conductivity of graphene laminate is increased by more than 50 times compared to that of as-deposited one. Graphene laminate with conductivity of 4.3 × 10{sup 4 }S/m and sheet resistance of 3.8 Ω/sq (with thickness of 6 μm) is presented. Moreover, the formation of graphene laminate from graphene ink reported here is simple and can be carried out in low temperature (100 °C), significantly reducing the fabrication costs. A dipole antenna based on the highly conductive graphene laminate is further patterned and printed on a normal paper to investigate its RF properties. The performance of the graphene laminate antenna is experimentally measured. The measurement results reveal that graphene laminate antenna can provide practically acceptable return loss, gain, bandwidth, and radiation patterns, making it ideal for low cost printed RF applications, such as RFID tags and wearable wireless sensor networks.

  9. Unconventional microbial systems for the cost-efficient production of high-quality protein therapeutics.

    Science.gov (United States)

    Corchero, José Luis; Gasser, Brigitte; Resina, David; Smith, Wesley; Parrilli, Ermenegilda; Vázquez, Felícitas; Abasolo, Ibane; Giuliani, Maria; Jäntti, Jussi; Ferrer, Pau; Saloheimo, Markku; Mattanovich, Diethard; Schwartz, Simó; Tutino, Maria Luisa; Villaverde, Antonio

    2013-01-01

    Both conventional and innovative biomedical approaches require cost-effective protein drugs with high therapeutic potency, improved bioavailability, biocompatibility, stability and pharmacokinetics. The growing longevity of the human population, the increasing incidence and prevalence of age-related diseases and the better comprehension of genetic-linked disorders prompt to develop natural and engineered drugs addressed to fulfill emerging therapeutic demands. Conventional microbial systems have been for long time exploited to produce biotherapeutics, competing with animal cells due to easier operation and lower process costs. However, both biological platforms exhibit important drawbacks (mainly associated to intracellular retention of the product, lack of post-translational modifications and conformational stresses), that cannot be overcome through further strain optimization merely due to physiological constraints. The metabolic diversity among microorganisms offers a spectrum of unconventional hosts, that, being able to bypass some of these weaknesses, are under progressive incorporation into production pipelines. In this review we describe the main biological traits and potentials of emerging bacterial, yeast, fungal and microalgae systems, by comparing selected leading species with well established conventional organisms with a long run in protein drug production.

  10. \\title{Low-Cost Bump-Bonding Processes for High Energy Physics Pixel Detectors}

    CERN Document Server

    Caselle, Michele; Colombo, Fabio; Dierlamm, Alexander Hermann; Husemann, Ulrich; Kudella, Simon; Weber, M

    2015-01-01

    In the next generation of collider experiments detectors will be challenged by unprecedented particle fluxes. Thus large detector arrays of highly pixelated detectors with minimal dead area at reasonable costs are required. Bump-bonding of pixel detectors has been shown to be a major cost-driver. KIT is one of the production centers of the CMS barrel pixel detector for the Phase I Upgrade. In this contribution the SnPb bump-bonding process and the production yield is reported. In parallel to the production of the new CMS pixel detector, several alternatives to the expensive photolithography electroplating/electroless metal deposition technologies are developing. Recent progress and challenges faced in the development of bump-bonding technology based on gold-stud bonding by thin ($15\\,\\rm{\\mu m}$) gold wire is presented. This technique allows producing metal bumps with diameters down to $30\\,\\rm{\\mu m}$ without using photolithography processes, which are typically required to provide suitable under bu...

  11. A Low-Cost, Portable, High-Throughput Wireless Sensor System for Phonocardiography Applications

    Directory of Open Access Journals (Sweden)

    Akkarapol Sa-ngasoongsong

    2012-08-01

    Full Text Available This paper presents the design and testing of a wireless sensor system developed using a Microchip PICDEM developer kit to acquire and monitor human heart sounds for phonocardiography applications. This system can serve as a cost-effective option to the recent developments in wireless phonocardiography sensors that have primarily focused on Bluetooth technology. This wireless sensor system has been designed and developed in-house using off-the-shelf components and open source software for remote and mobile applications. The small form factor (3.75 cm ´ 5 cm ´ 1 cm, high throughput (6,000 Hz data streaming rate, and low cost ($13 per unit for a 1,000 unit batch of this wireless sensor system make it particularly attractive for phonocardiography and other sensing applications. The experimental results of sensor signal analysis using several signal characterization techniques suggest that this wireless sensor system can capture both fundamental heart sounds (S1 and S2, and is also capable of capturing abnormal heart sounds (S3 and S4 and heart murmurs without aliasing. The results of a denoising application using Wavelet Transform show that the undesirable noises of sensor signals in the surrounding environment can be reduced dramatically. The exercising experiment results also show that this proposed wireless PCG system can capture heart sounds over different heart conditions simulated by varying heart rates of six subjects over a range of 60–180 Hz through exercise testing.

  12. End-of-life care in nursing homes: the high cost of staff turnover.

    Science.gov (United States)

    Tilden, Virginia P; Thompson, Sarah A; Gajewski, Byron J; Bott, Marjorie J

    2012-01-01

    Nursing home staff turnover results in high cost--both economic and personal--and has a negative impact on the quality of care provided to residents at the end of life. Reducing staff turnover in nursing homes would benefit both the cost to the U.S. health care system, and, most importantly, the care residents receive in the vulnerable period leading to death. There is rising pressure on nursing homes to improve their palliative and end-of-life care practices and reduce transfers to hospital for situations and conditions that can be safely managed on site. Nursing care staff deserve an investment in the specific training necessary for them to give the highest quality care to dying residents. This training should be multifaceted and include the physiological, psychological, spiritual, interpersonal, and cultural (including ethnic) aspects of dying. Empowerment with these necessary knowledge, skills, and attitudes will not only result in better care for residents but likely also will reduce the burnout and frustration staff experience in caring for residents near death.

  13. High-response intrauterine insemination cycles converted to low-cost in vitro fertilization

    Directory of Open Access Journals (Sweden)

    Aletebi F

    2011-05-01

    Full Text Available Fatma AletebiAssisted Reproduction Unit, Department of Obstetrics and Gynaecology, King Abdulaziz University, Soliman Fakeeh Hospital, Jeddah, Saudi ArabiaBackground: There is a trend to cancel intrauterine insemination (IUI in women with a high response. The aim of this study was to evaluate the efficacy of low-cost in vitro fertilization (IVF in high-response IUI cycles in comparison with conventional IVF.Methods and materials: A total of 46 women were included in the study. Group A (study group included 23 women with hyper-response to IUI cycles who were converted to IVF. They received oral letrozole 2.5 mg twice daily from days 3–7 of the menstrual cycle, along with 75 International Units (IU of recombinant follicle-stimulating hormone on days 3 and 8. Group B (control group underwent conventional IVF, and received downregulation with a gonadotrophin-releasing hormone agonist followed by stimulation with recombinant follicle-stimulating hormone 150–300 IU/day. Ovulation was triggered by 10,000 IU of human chorionic gonadotrophin, followed by IVF and embryo transfer. The primary outcome measure analyzed was pregnancy rates in both groups.Results: The study group received a significantly lower (P = 0.001 total dose of follicle-stimulating hormone and had significantly (P = 0.002 decreased levels of terminal estradiol. Although the pregnancy rate (30.43% in the study group versus 39.13% in the conventional group per stimulated cycle was higher in the conventional IVF group, the miscarriage rate (study group 4.34% versus conventional group 13.04% was also higher, and hence the take-home baby rate (study group 26.08% versus conventional group 30.43% was more or less similar in both the groups.Conclusion: IVF can be offered to women having a high response to IUI cycles with good pregnancy rates and at low cost compared with use of a conventional protocol, and therefore can be considered more patient-friendly in selected cases.Keywords: low-cost

  14. Enhanced alcohol self-administration and reinstatement in a highly impulsive, inattentive recombinant inbred mouse strain

    Directory of Open Access Journals (Sweden)

    Maarten eLoos

    2013-10-01

    Full Text Available Deficits in executive control have frequently been associated with alcohol use disorder. Here we investigated to what extent pre-existing genetically encoded levels of impulsive/inattentive behavior associate with motivation to take alcohol and vulnerability to cue-induced reinstatement of alcohol seeking in an operant self-administration paradigm. We took advantage of BXD16, a recombinant inbred strain previously shown to have enhanced impulsivity and poor attentional control. We compared BXD16 with C57BL/6J mice in a simple choice reaction time task (SCRTT and confirmed its impulsive/inattentive phenotype. BXD16 mice were less active in a novel open field, and were equally active in an automated home cage environment, showing that increased impulsive responding of BXD16 mice could not be explained by enhanced general activity compared to C57BL/6J mice. After training in a sucrose/alcohol fading self-administration procedure, BXD16 showed increased motivation to earn 10% alcohol solution, both under fixed ratio (FR1 and progressive ratio (PR2 schedules of reinforcement. Responding on the active lever readily decreased during extinction training with no apparent differences between strains. However, upon re-exposure to alcohol-associated cues, alcohol seeking was reinstated to a larger extent in BXD16 than in C57BL/6J mice. Although further studies are needed to determine whether impulsivity/inattention and alcohol seeking depend on common or separate genetic loci, these data show that in mice enhanced impulsivity coincides with increased motivation to take alcohol, as well as relapse vulnerability.

  15. Descriptive analysis of childbirth healthcare costs in an area with high levels of immigration in Spain

    Directory of Open Access Journals (Sweden)

    Sala Maria

    2011-04-01

    Full Text Available Abstract Background The aim of this study was to estimate the cost of childbirth in a teaching hospital in Barcelona, Spain, including the costs of prenatal care, delivery and postnatal care (3 months. Costs were assessed by taking into account maternal origin and delivery type. Methods We performed a cross-sectional study of all deliveries in a teaching hospital to mothers living in its catchment area between October 2006 and September 2007. A process cost analysis based on a full cost accounting system was performed. The main information sources were the primary care program for sexual and reproductive health, and hospital care and costs records. Partial and total costs were compared according to maternal origin and delivery type. A regression model was fit to explain the total cost of the childbirth process as a function of maternal age and origin, prenatal care, delivery type, maternal and neonatal severity, and multiple delivery. Results The average cost of childbirth was 4,328€, with an average of 18.28 contacts between the mother or the newborn and the healthcare facilities. The delivery itself accounted for more than 75% of the overall cost: maternal admission accounted for 57% and neonatal admission for 20%. Prenatal care represented 18% of the overall cost and 75% of overall acts. The average overall cost was 5,815€ for cesarean sections, 4,064€ for vaginal instrumented deliveries and 3,682€ for vaginal non-instrumented deliveries (p Conclusions Neither immigration nor prenatal care were associated with a substantial difference in costs. The most important predictors of cost were delivery type and neonatal severity. Given the impact of cesarean sections on the overall cost of childbirth, attempts should be made to take into account its higher cost in the decision of performing a cesarean section.

  16. Use of highly alkaline conditions to improve cost-effectiveness of algal biotechnology.

    Science.gov (United States)

    Canon-Rubio, Karen A; Sharp, Christine E; Bergerson, Joule; Strous, Marc; De la Hoz Siegler, Hector

    2016-02-01

    Phototrophic microorganisms have been proposed as an alternative to capture carbon dioxide (CO2) and to produce biofuels and other valuable products. Low CO2 absorption rates, low volumetric productivities, and inefficient downstream processing, however, currently make algal biotechnology highly energy intensive, expensive, and not economically competitive to produce biofuels. This mini-review summarizes advances made regarding the cultivation of phototrophic microorganisms at highly alkaline conditions, as well as other innovations oriented toward reducing the energy input into the cultivation and processing stages. An evaluation, in terms of energy requirements and energy return on energy invested, is performed for an integrated high-pH, high-alkalinity growth process that uses biofilms. Performance in terms of productivity and expected energy return on energy invested is presented for this process and is compared to previously reported life cycle assessments (LCAs) for systems at near-neutral pH. The cultivation of alkaliphilic phototrophic microorganisms in biofilms is shown to have a significant potential to reduce both energy requirements and capital costs.

  17. 7 CFR 1709.5 - Determination of energy cost benchmarks.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Determination of energy cost benchmarks. 1709.5... SERVICE, DEPARTMENT OF AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES General Requirements § 1709.5 Determination of energy cost benchmarks. (a) The Administrator shall establish, using the...

  18. Is a biomarker-based diagnostic strategy for invasive aspergillosis cost effective in high-risk haematology patients?

    Science.gov (United States)

    Macesic, N; Morrissey, C O; Liew, D; Bohensky, M A; Chen, S C-A; Gilroy, N M; Milliken, S T; Szer, J; Slavin, M A

    2017-01-27

    Empirical antifungal therapy is frequently used in hematology patients at high risk of invasive aspergillosis (IA), with substantial cost and toxicity. Biomarkers for IA aim for earlier and more accurate diagnosis and targeted treatment. However, data on the cost-effectiveness of a biomarker-based diagnostic strategy (BDS) are limited. We evaluated the cost effectiveness of BDS using results from a randomized controlled trial (RCT) and individual patient costing data. Data inputs derived from a published RCT were used to construct a decision-analytic model to compare BDS (Aspergillus galactomannan and PCR on blood) with standard diagnostic strategy (SDS) of culture and histology in terms of total costs, length of stay, IA incidence, mortality, and years of life saved. Costs were estimated for each patient using hospital costing data to day 180 and follow-up for survival was modeled to five years using a Gompertz survival model. Treatment costs were determined for 137 adults undergoing allogeneic hematopoietic stem cell transplant or receiving chemotherapy for acute leukemia in four Australian centers (2005-2009). Median total costs at 180 days were similar between groups (US[Formula: see text] for SDS [IQR US[Formula: see text

  19. 78 FR 26269 - Connect America Fund; High-Cost Universal Service Support

    Science.gov (United States)

    2013-05-06

    ... current version of the CAM suggest that this better calibrated approach results in more reliable cost... funding) are roughly 20-25 percent lower in the current version of the CAM than in the cost model... network costs are assets with an accounting lifetime of 20 years or more, such as loop plant,...

  20. Multimorbidity and healthcare utilisation among high-cost patients in the US Veterans Affairs Health Care System.

    Science.gov (United States)

    Zulman, Donna M; Pal Chee, Christine; Wagner, Todd H; Yoon, Jean; Cohen, Danielle M; Holmes, Tyson H; Ritchie, Christine; Asch, Steven M

    2015-04-16

    To investigate the relationship between multimorbidity and healthcare utilisation patterns among the highest cost patients in a large, integrated healthcare system. In this retrospective cross-sectional study of all patients in the U.S. Veterans Affairs (VA) Health Care System, we aggregated costs of individuals' outpatient and inpatient care, pharmacy services and VA-sponsored contract care received in 2010. We assessed chronic condition prevalence, multimorbidity as measured by comorbidity count, and multisystem multimorbidity (number of body systems affected by chronic conditions) among the 5% highest cost patients. Using multivariate regression, we examined the association between multimorbidity and healthcare utilisation and costs, adjusting for age, sex, race/ethnicity, marital status, homelessness and health insurance status. USA VA Health Care System. 5.2 million VA patients. Annual total costs; absolute and share of costs generated through outpatient, inpatient, pharmacy and VA-sponsored contract care; number of visits to primary, specialty and mental healthcare; number of emergency department visits and hospitalisations. The 5% highest cost patients (n=261,699) accounted for 47% of total VA costs. Approximately two-thirds of these patients had chronic conditions affecting ≥3 body systems. Patients with cancer and schizophrenia were less likely to have documented comorbid conditions than other high-cost patients. Multimorbidity was generally associated with greater outpatient and inpatient utilisation. However, increased multisystem multimorbidity was associated with a higher outpatient share of total costs (1.6 percentage points per affected body system, psystem, p<0.01). Multisystem multimorbidity is common among high-cost VA patients. While some patients might benefit from disease-specific programmes, for most patients with multimorbidity there is a need for interventions that coordinate and maximise efficiency of outpatient services across multiple

  1. High Cost Performance Organic-Inorganic Hybrid Material for Electro-optic Devices

    Institute of Scientific and Technical Information of China (English)

    SUN Jie; ZHU Gui-Hua; SUN Xiao-Qiang; LI Tong; GAO Wei-Nan; ZHANG Da-Ming; HOU A-lin

    2009-01-01

    We report a low-cost electro-optic (EO) sol-gel material with large EO coefficient and excellent poling stability for EO devices. Disperse red 1 (DR1) chromophore is doped in the three-dimensional silicon dioxide/titanium dioxide network possessing a high γ33 (88pm/V at 1300 nm wavelength and 71 pm/V at 1550nm wavelength). Favourable poled stability (less than 5% relaxed after 2500 hours at 80 ℃) and low absorption are demonstrated. Strip-loaded waveguide Mach-Zehnder (M-Z) modulators are implemented based on this synthesized EO material, showing 7 V half-wave voltage and less than 9dB insertion loss at 1550nm wavelength.

  2. A Rapid and Cost-Effective Laser Based Synthesis of High Purity Cadmium Selenide Quantum Dots.

    Science.gov (United States)

    Gondall, M A; Qahtan, Talal F; Dastageer, M A; Yamani, Z H; Anjum, D H

    2016-01-01

    A rapid and cost effective method is developed to synthesize high purity cadmium Selenide (CdSe) quantum dots in acetone medium using second harmonic of Nd:YAG nanosecond pulsed laser of 532 nm wavelength. The thermal agglomeration due the nanosecond pulse duration of the laser was successfully eliminated by using unfocussed laser beam and thereby providing a favorable conditions for the synthesis of quantum dots having the grain size of 3 nm. The morphological and optical characterizations like XRD, HRTEM, optical absorption of the synthesized CdSe quantum dots, reveal that the material possesses the similar characteristics of the one synthesized through cumbersome wet chemical methods. Relative to the CdSe bulk material, the synthesized CdSe quantum dots showed a blue shift in the measured band gap energy from near infrared spectral region to visible region, making this material very attractive for many solar energy harvesting applications like photo-catalysis and solar cells.

  3. Are High Labour Costs Destroying the Competitiveness of Danish Dairy Farmers?

    DEFF Research Database (Denmark)

    Asmild, Mette; Nielsen, Kurt; Bogetoft, Peter

    This paper analysis the competitiveness of Danish dairy farmers relative to dairy farmers in other Northern European countries. We use individual farm accounts data from the European Commission’s Farm Accountancy Data Network (FADN) and have an average of 1665 observations per year in the period...... on the differences in average efficiencies between countries. The results shows that the Danish dairy farmers, on average, were the most economically efficient in Northern Europe in 2007 and 2008. We find that the effect of labour costs for the Danish dairy farmers is decreasing during the study period despite...... of the salary differences increasing. In 2002 the negative impact of having the highest hourly pay was an average 4.7 percentage points whereas it in 2008 was only 0.6 percentage points.This indicates that the Danish dairy farmers have been highly successful in adapting to having the highest, and increasing...

  4. A cost-effective high-flux source of cold ytterbium atoms

    Science.gov (United States)

    Song, Bo; Zou, Yueyang; Zhang, Shanchao; Cho, Chang-woo; Jo, Gyu-Boong

    2016-10-01

    We report a cost-effective way to prepare high-flux slow ytterbium atoms with extremely low-power 399-nm light suitable for the production of quantum degenerate ytterbium gases. By collimating an atomic beam through an array of micro-capillary tubes, we obtain a bright atomic beam through the Zeeman slower operating at low light power of only 15 mW for the source. We achieve the loading rate of 2 × 107 s-1 into the intercombination magneto-optical trap (MOT) and a sufficient steady-state MOT atom number of 2 × 108 for 174Yb atoms. Our apparatus highlights an efficient method to obtain slow ytterbium atoms using a simple low-power 399-nm laser system.

  5. A Low-Cost Time-Hopping Impulse Radio System for High Data Rate Transmission

    Directory of Open Access Journals (Sweden)

    Jinyun Zhang

    2005-03-01

    Full Text Available We present an efficient, low-cost implementation of time-hopping impulse radio that fulfills the spectral mask mandated by the FCC and is suitable for high-data-rate, short-range communications. Key features are (i all-baseband implementation that obviates the need for passband components, (ii symbol-rate (not chip rate sampling, A/D conversion, and digital signal processing, (iii fast acquisition due to novel search algorithms, and (iv spectral shaping that can be adapted to accommodate different spectrum regulations and interference environments. Computer simulations show that this system can provide 110 Mbps at 7–10 m distance, as well as higher data rates at shorter distances under FCC emissions limits. Due to the spreading concept of time-hopping impulse radio, the system can sustain multiple simultaneous users, and can suppress narrowband interference effectively.

  6. Social Security Administration

    Science.gov (United States)

    ... Languages Sign in / up The United States Social Security Administration Cost-Of-Living Adjustment (COLA) Information about ... replacement Medicare card Change of Address my Social Security Check out your Social Security Statement , change your ...

  7. Low-cost, high-speed back-end processing system for high-frequency ultrasound B-mode imaging.

    Science.gov (United States)

    Chang, Jin Ho; Sun, Lei; Yen, Jesse T; Shung, K Kirk

    2009-07-01

    For real-time visualization of the mouse heart (6 to 13 beats per second), a back-end processing system involving high-speed signal processing functions to form and display images has been developed. This back-end system was designed with new signal processing algorithms to achieve a frame rate of more than 400 images per second. These algorithms were implemented in a simple and cost-effective manner with a single field-programmable gate array (FPGA) and software programs written in C++. The operating speed of the back-end system was investigated by recording the time required for transferring an image to a personal computer. Experimental results showed that the back-end system is capable of producing 433 images per second. To evaluate the imaging performance of the back-end system, a complete imaging system was built. This imaging system, which consisted of a recently reported high-speed mechanical sector scanner assembled with the back-end system, was tested by imaging a wire phantom, a pig eye (in vitro), and a mouse heart (in vivo). It was shown that this system is capable of providing high spatial resolution images with fast temporal resolution.

  8. Analyzing the Cost-Effectiveness of Instruction Expenditures towards High School Completion among Oahu's Public School Districts

    Science.gov (United States)

    Ng, Larson S. W. M.

    2011-01-01

    The following study attempted to ascertain the instructional cost-effectiveness of public high school teachers towards high school completion through a financially based econometric analysis. Essentially, public high school instruction expenditures and completer data were collected from 2000 to 2007 and bivariate interaction analyzed through a…

  9. The High Cost of Failing to Reform Public Education in Texas. School Choice Issues in the State

    Science.gov (United States)

    Gottlob, Brian J.

    2008-01-01

    Research has documented a crisis in Texas high school graduation rates. Only 67 percent of Texas students graduate from high school, and some large urban districts have graduation rates of 50 percent or lower. This study documents the public costs of high school dropouts in Texas and examines how school choice could provide large public benefits…

  10. High Temperature Thermoplastic Additive Manufacturing Using Low-Cost, Open-Source Hardware

    Science.gov (United States)

    Gardner, John M.; Stelter, Christopher J.; Yashin, Edward A.; Siochi, Emilie J.

    2016-01-01

    Additive manufacturing (or 3D printing) via Fused Filament Fabrication (FFF), also known as Fused Deposition Modeling (FDM), is a process where material is placed in specific locations layer-by-layer to create a complete part. Printers designed for FFF build parts by extruding a thermoplastic filament from a nozzle in a predetermined path. Originally developed for commercial printers, 3D printing via FFF has become accessible to a much larger community of users since the introduction of Reprap printers. These low-cost, desktop machines are typically used to print prototype parts or novelty items. As the adoption of desktop sized 3D printers broadens, there is increased demand for these machines to produce functional parts that can withstand harsher conditions such as high temperature and mechanical loads. Materials meeting these requirements tend to possess better mechanical properties and higher glass transition temperatures (Tg), thus requiring printers with high temperature printing capability. This report outlines the problems and solutions, and includes a detailed description of the machine design, printing parameters, and processes specific to high temperature thermoplastic 3D printing.

  11. Enabling low cost biopharmaceuticals: high level interferon alpha-2b production in Trichoderma reesei.

    Science.gov (United States)

    Landowski, Christopher P; Mustalahti, Eero; Wahl, Ramon; Croute, Laurence; Sivasiddarthan, Dhinakaran; Westerholm-Parvinen, Ann; Sommer, Benjamin; Ostermeier, Christian; Helk, Bernhard; Saarinen, Juhani; Saloheimo, Markku

    2016-06-10

    The filamentous fungus Trichoderma reesei has tremendous capability to secrete over 100 g/L of proteins and therefore it would make an excellent host system for production of high levels of therapeutic proteins at low cost. We have developed T. reesei strains suitable for production of therapeutic proteins by reducing the secreted protease activity. Protease activity has been the major hindrance to achieving high production levels. We have constructed a series of interferon alpha-2b (IFNα-2b) production strains with 9 protease deletions to gain knowledge for further strain development. We have identified two protease deletions that dramatically improved the production levels. Deletion of the subtilisin protease slp7 and the metalloprotease amp2 has enabled production levels of IFNα-2b up to 2.1 and 2.4 g/L, respectively. With addition of soybean trypsin protease inhibitor the level of production improved to 4.5 g/L, with an additional 1.8 g/L still bound to the secretion carrier protein. High levels of IFNα-2b were produced using T. reesei strains with reduced protease secretion. Further strain development can be done to improve the production system by reducing protease activity and improving carrier protein cleavage.

  12. Electrochemistry-based approaches to low cost, high sensitivity, automated, multiplexed protein immunoassays for cancer diagnostics.

    Science.gov (United States)

    Dixit, Chandra K; Kadimisetty, Karteek; Otieno, Brunah A; Tang, Chi; Malla, Spundana; Krause, Colleen E; Rusling, James F

    2016-01-21

    Early detection and reliable diagnostics are keys to effectively design cancer therapies with better prognoses. The simultaneous detection of panels of biomarker proteins holds great promise as a general tool for reliable cancer diagnostics. A major challenge in designing such a panel is to decide upon a coherent group of biomarkers which have higher specificity for a given type of cancer. The second big challenge is to develop test devices to measure these biomarkers quantitatively with high sensitivity and specificity, such that there are no interferences from the complex serum or tissue matrices. Lastly, integrating all these tests into a technology that does not require exclusive training to operate, and can be used at point-of-care (POC) is another potential bottleneck in futuristic cancer diagnostics. In this article, we review electrochemistry-based tools and technologies developed and/or used in our laboratories to construct low-cost microfluidic protein arrays for the highly sensitive detection of a panel of cancer-specific biomarkers with high specificity which at the same time has the potential to be translated into POC applications.

  13. Low cost, single crystal-like substrates for practical, high efficiency solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Goyal, A.; Specht, E.D.; List, F.A. [and others

    1997-09-01

    It is well established that high efficiency (20%) solar cells can be routinely fabricated using single crystal photovoltaic (PV) materials with low defect densities. Polycrystalline materials with small grain sizes and no crystallographic texture typically result in reduced efficiences. This has been ascribed primarily to the presence of grain boundaries and their effect on recombination processes. Furthermore, lack of crystallographic texture can result in a large variation in dopant concentrations which critically control the electronic properties of the material. Hence in order to reproducibly fabricate high efficiency solar cells a method which results in near single crystal material is desirable. Bulk single crystal growth of PV materials is cumbersome, expensive and difficult to scale up. We present here a possible route to achieve this if epitaxial growth of photovoltaic materials on rolling-assisted-biaxially textured-substrates (RABiTS) can be achieved. The RABiTS process uses well-established, industrially scaleable, thermomechanical processing to produce a biaxially textured or single-crystal-like metal substrate with large grains (50-100 {mu}m). This is followed by epitaxial growth of suitable buffer layers to yield chemically and structurally compatible surfaces for epitaxial growth of device materials. Using the RABiTS process it should be possible to economically fabricate single-crystal-like substrates of desired sizes. Epitaxial growth of photovoltaic devices on such substrates presents a possible route to obtaining low-cost, high performance solar cells.

  14. High-Density, High-Resolution, Low-Cost Air Quality Sensor Networks for Urban Air Monitoring

    Science.gov (United States)

    Mead, M. I.; Popoola, O. A.; Stewart, G.; Bright, V.; Kaye, P.; Saffell, J.

    2012-12-01

    Monitoring air quality in highly granular environments such as urban areas which are spatially heterogeneous with variable emission sources, measurements need to be made at appropriate spatial and temporal scales. Current routine air quality monitoring networks generally are either composed of sparse expensive installations (incorporating e.g. chemiluminescence instruments) or higher density low time resolution systems (e.g. NO2 diffusion tubes). Either approach may not accurately capture important effects such as pollutant "hot spots" or adequately capture spatial (or temporal) variability. As a result, analysis based on data from traditional low spatial resolution networks, such as personal exposure, may be inaccurate. In this paper we present details of a sophisticated, low-cost, multi species (gas phase, speciated PM, meteorology) air quality measurement network methodology incorporating GPS and GPRS which has been developed for high resolution air quality measurements in urban areas. Sensor networks developed in the Centre for Atmospheric Science (University of Cambridge) incorporated electrochemical gas sensors configured for use in urban air quality studies operating at parts-per-billion (ppb) levels. It has been demonstrated that these sensors can be used to measure key air quality gases such as CO, NO and NO2 at the low ppb mixing ratios present in the urban environment (estimated detection limits work, a state of the art multi species instrument package for deployment in scalable sensor networks has been developed which has general applicability. This is currently being employed as part of a major 3 year UK program at London Heathrow airport (the Sensor Networks for Air Quality (SNAQ) Heathrow project). The main project outcome is the creation of a calibrated, high spatial and temporal resolution data set for O3, NO, NO2, SO2, CO, CO2, VOCstotal, size-speciated PM, temperature, relative humidity, wind speed and direction. The network incorporates existing

  15. Medicare Cost Reports

    Data.gov (United States)

    U.S. Department of Health & Human Services — Medicare certified institutional providers are required to submit an annual cost report to a Medicare Administrative Contractor. The cost report contains provider...

  16. Transformational Electronics: Towards Flexible Low-Cost High Mobility Channel Materials

    KAUST Repository

    Nassar, Joanna M.

    2014-05-01

    For the last four decades, Si CMOS technology has been advancing with Moore’s law prediction, working itself down to the sub-20 nm regime. However, fundamental problems and limitations arise with the down-scaling of transistors and thus new innovations needed to be discovered in order to further improve device performance without compromising power consumption and size. Thus, a lot of studies have focused on the development of new CMOS compatible architectures as well as the discovery of new high mobility channel materials that will allow further miniaturization of CMOS transistors and improvement of device performance. Pushing the limits even further, flexible and foldable electronics seem to be the new attractive topic. By being able to make our devices flexible through a CMOS compatible process, one will be able to integrate hundreds of billions of more transistors in a small volumetric space, allowing to increase the performance and speed of our electronics all together with making things thinner, lighter, smaller and even interactive with the human skin. Thus, in this thesis, we introduce for the first time a cost-effective CMOS compatible approach to make high-k/metal gate devices on flexible Germanium (Ge) and Silicon-Germanium (SiGe) platforms. In the first part, we will look at the various approaches in the literature that has been developed to get flexible platforms, as well as we will give a brief overview about epitaxial growth of Si1-xGex films. We will also examine the electrical properties of the Si1-xGex alloys up to Ge (x=1) and discuss how strain affects the band structure diagram, and thus the mobility of the material. We will also review the material growth properties as well as the state-of-the-art results on high mobility metal-oxide semiconductor capacitors (MOSCAPs) using strained SiGe films. Then, we will introduce the flexible process that we have developed, based on a cost-effective “trench-protect-release-reuse” approach, utilizing

  17. Low-cost, High Titanium Mare Simulant: Bulk, Dust and "Orange Spheres" Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Space exploration require simulants for equipment design, development and testing. This proposal directly responds to the solicitation by improving simulant...

  18. Low-Cost High-Performance Hall Thruster Support System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Colorado Power Electronics (CPE) has built an innovative modular power processing unit (PPU) for Hall Thrusters, including discharge, magnet, heater and keeper...

  19. Manufacturing Cost Analysis of Novel Steel/Concrete Composite Vessel for Stationary Storage of High-Pressure Hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Zhili [ORNL; Zhang, Wei [ORNL; Wang, Jy-An John [ORNL; Ren, Fei [ORNL

    2012-09-01

    A novel, low-cost, high-pressure, steel/concrete composite vessel (SCCV) technology for stationary storage of compressed gaseous hydrogen (CGH2) is currently under development at Oak Ridge National Laboratory (ORNL) sponsored by DOE s Fuel Cell Technologies (FCT) Program. The SCCV technology uses commodity materials including structural steels and concretes for achieving cost, durability and safety requirements. In particular, the hydrogen embrittlement of high-strength low-alloy steels, a major safety and durability issue for current industry-standard pressure vessel technology, is mitigated through the use of a unique layered steel shell structure. This report presents the cost analysis results of the novel SCCV technology. A high-fidelity cost analysis tool is developed, based on a detailed, bottom-up approach which takes into account the material and labor costs involved in each of the vessel manufacturing steps. A thorough cost study is performed to understand the SCCV cost as a function of the key vessel design parameters, including hydrogen pressure, vessel dimensions, and load-carrying ratio. The major conclusions include: The SCCV technology can meet the technical/cost targets set forth by DOE s FCT Program for FY2015 and FY2020 for all three pressure levels (i.e., 160, 430 and 860 bar) relevant to the hydrogen production and delivery infrastructure. Further vessel cost reduction can benefit from the development of advanced vessel fabrication technologies such as the highly automated friction stir welding (FSW). The ORNL-patented multi-layer, multi-pass FSW can not only reduce the amount of labor needed for assembling and welding the layered steel vessel, but also make it possible to use even higher strength steels for further cost reductions and improvement of vessel structural integrity. It is noted the cost analysis results demonstrate the significant cost advantage attainable by the SCCV technology for different pressure levels when compared to the

  20. Building America Case Study: Performance and Costs of Ductless Heat Pumps in Marine Climate High-Performance Homes: Habitat for Humanity -- The Woods, Tacoma, Washington

    Energy Technology Data Exchange (ETDEWEB)

    2016-02-01

    The Woods is a Habitat for Humanity (HFH) community of ENERGY STAR Homes (c) Northwest (ESHNW)-certified homes located in the marine climate of Tacoma/Pierce County, Washington. This research report builds on an earlier preliminary draft 2014 BA report, and includes significant billing analysis and cost effectiveness research from a collaborative, ongoing Ductless Heat Pump (DHP) research effort for Tacoma Public Utilities (TPU) and Bonneville Power Administration (BPA). This report focuses on the results of field testing, modeling, and monitoring of ductless mini-split heat pump hybrid heating systems in seven homes built and first occupied at various times between September 2013 and October 2014. The report also provides WSU documentation of high-performance home observations, lessons learned, and stakeholder recommendations for builders of affordable high-performance housing such as HFH.

  1. Research on cost control and management in high voltage transmission line construction

    Science.gov (United States)

    Xu, Xiaobin

    2017-05-01

    Enterprises. The cost control is of vital importance to the construction enterprises. It is the key to the profitability of the transmission line project, which is related to the survival and development of the electric power construction enterprises. Due to the long construction line, complex and changeable construction terrain as well as large construction costs of transmission line, it is difficult for us to take accurate and effective cost control on the project implementation of entire transmission line. Therefore, the cost control of transmission line project is a complicated and arduous task. It is of great theoretical and practical significance to study the cost control scheme of transmission line project by a more scientific and efficient way. Based on the characteristics of the construction project of the transmission line project, this paper analyzes the construction cost structure of the transmission line project and the current cost control problem of the transmission line project, and demonstrates the necessity and feasibility of studying the cost control scheme of the transmission line project more accurately. In this way, the dynamic cycle cost control process including plan, implementation, feedback, correction, modification and re-implement is achieved to realize the accurate and effective cost control of entire electric power transmission line project.

  2. Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis.

    Directory of Open Access Journals (Sweden)

    Emmanuel Dias-Neto

    Full Text Available BACKGROUND: Combinatorial phage display has been used in the last 20 years in the identification of protein-ligands and protein-protein interactions, uncovering relevant molecular recognition events. Rate-limiting steps of combinatorial phage display library selection are (i the counting of transducing units and (ii the sequencing of the encoded displayed ligands. Here, we adapted emerging genomic technologies to minimize such challenges. METHODOLOGY/PRINCIPAL FINDINGS: We gained efficiency by applying in tandem real-time PCR for rapid quantification to enable bacteria-free phage display library screening, and added phage DNA next-generation sequencing for large-scale ligand analysis, reporting a fully integrated set of high-throughput quantitative and analytical tools. The approach is far less labor-intensive and allows rigorous quantification; for medical applications, including selections in patients, it also represents an advance for quantitative distribution analysis and ligand identification of hundreds of thousands of targeted particles from patient-derived biopsy or autopsy in a longer timeframe post library administration. Additional advantages over current methods include increased sensitivity, less variability, enhanced linearity, scalability, and accuracy at much lower cost. Sequences obtained by qPhage plus pyrosequencing were similar to a dataset produced from conventional Sanger-sequenced transducing-units (TU, with no biases due to GC content, codon usage, and amino acid or peptide frequency. These tools allow phage display selection and ligand analysis at >1,000-fold faster rate, and reduce costs approximately 250-fold for generating 10(6 ligand sequences. CONCLUSIONS/SIGNIFICANCE: Our analyses demonstrates that whereas this approach correlates with the traditional colony-counting, it is also capable of a much larger sampling, allowing a faster, less expensive, more accurate and consistent analysis of phage enrichment. Overall

  3. Monitoring High-Frequency Ocean Signals Using Low-Cost Gnss/imu Buoys

    Science.gov (United States)

    Huang, Yu-Lun; Kuo, Chung-Yen; Shih, Chiao-Hui; Lin, Li-Ching; Chiang, Kai-wei; Cheng, Kai-Chien

    2016-06-01

    In oceans there are different ocean signals covering the multi-frequencies including tsunami, meteotsunami, storm surge, as sea level change, and currents. These signals have the direct and significant impact on the economy and life of human-beings. Therefore, measuring ocean signals accurately becomes more and more important and necessary. Nowadays, there are many techniques and methods commonly used for monitoring oceans, but each has its limitation. For example, tide gauges only measure sea level relative to benchmarks and are disturbed unevenly, and satellite altimeter measurements are not continuous and inaccurate near coastal oceans. In addition, high-frequency ocean signals such as tsunami and meteotsunami cannot be sufficiently detected by 6-minutes tide gauge measurements or 10-day sampled altimetry data. Moreover, traditional accelerometer buoy is heavy, expensive and the low-frequency noise caused by the instrument is unavoidable. In this study, a small, low-cost and self-assembly autonomous Inertial Measurement Unit (IMU) that independently collects continuous acceleration and angular velocity data is mounted on a GNSS buoy to provide the positions and tilts of the moving buoy. The main idea is to integrate the Differential GNSS (DGNSS) or Precise Point Positioning (PPP) solutions with IMU data, and then evaluate the performance by comparing with in situ tide gauges. The validation experiments conducted in the NCKU Tainan Hydraulics Laboratory showed that GNSS and IMU both can detect the simulated regular wave frequency and height, and the field experiments in the Anping Harbor, Tainan, Taiwan showed that the low-cost GNSS buoy has an excellent ability to observe significant wave heights in amplitude and frequency.

  4. MONITORING HIGH-FREQUENCY OCEAN SIGNALS USING LOW-COST GNSS/IMU BUOYS

    Directory of Open Access Journals (Sweden)

    Y.-L. Huang

    2016-06-01

    Full Text Available In oceans there are different ocean signals covering the multi-frequencies including tsunami, meteotsunami, storm surge, as sea level change, and currents. These signals have the direct and significant impact on the economy and life of human-beings. Therefore, measuring ocean signals accurately becomes more and more important and necessary. Nowadays, there are many techniques and methods commonly used for monitoring oceans, but each has its limitation. For example, tide gauges only measure sea level relative to benchmarks and are disturbed unevenly, and satellite altimeter measurements are not continuous and inaccurate near coastal oceans. In addition, high-frequency ocean signals such as tsunami and meteotsunami cannot be sufficiently detected by 6-minutes tide gauge measurements or 10-day sampled altimetry data. Moreover, traditional accelerometer buoy is heavy, expensive and the low-frequency noise caused by the instrument is unavoidable. In this study, a small, low-cost and self-assembly autonomous Inertial Measurement Unit (IMU that independently collects continuous acceleration and angular velocity data is mounted on a GNSS buoy to provide the positions and tilts of the moving buoy. The main idea is to integrate the Differential GNSS (DGNSS or Precise Point Positioning (PPP solutions with IMU data, and then evaluate the performance by comparing with in situ tide gauges. The validation experiments conducted in the NCKU Tainan Hydraulics Laboratory showed that GNSS and IMU both can detect the simulated regular wave frequency and height, and the field experiments in the Anping Harbor, Tainan, Taiwan showed that the low-cost GNSS buoy has an excellent ability to observe significant wave heights in amplitude and frequency.

  5. Offering Lung Cancer Screening to High-Risk Medicare Beneficiaries Saves Lives and Is Cost-Effective: An Actuarial Analysis

    Science.gov (United States)

    Pyenson, Bruce S.; Henschke, Claudia I.; Yankelevitz, David F.; Yip, Rowena; Dec, Ellynne

    2014-01-01

    Background By a wide margin, lung cancer is the most significant cause of cancer death in the United States and worldwide. The incidence of lung cancer increases with age, and Medicare beneficiaries are often at increased risk. Because of its demonstrated effectiveness in reducing mortality, lung cancer screening with low-dose computed tomography (LDCT) imaging will be covered without cost-sharing starting January 1, 2015, by nongrandfathered commercial plans. Medicare is considering coverage for lung cancer screening. Objective To estimate the cost and cost-effectiveness (ie, cost per life-year saved) of LDCT lung cancer screening of the Medicare population at high risk for lung cancer. Methods Medicare costs, enrollment, and demographics were used for this study; they were derived from the 2012 Centers for Medicare & Medicaid Services (CMS) beneficiary files and were forecast to 2014 based on CMS and US Census Bureau projections. Standard life and health actuarial techniques were used to calculate the cost and cost-effectiveness of lung cancer screening. The cost, incidence rates, mortality rates, and other parameters chosen by the authors were taken from actual Medicare data, and the modeled screenings are consistent with Medicare processes and procedures. Results Approximately 4.9 million high-risk Medicare beneficiaries would meet criteria for lung cancer screening in 2014. Without screening, Medicare patients newly diagnosed with lung cancer have an average life expectancy of approximately 3 years. Based on our analysis, the average annual cost of LDCT lung cancer screening in Medicare is estimated to be $241 per person screened. LDCT screening for lung cancer in Medicare beneficiaries aged 55 to 80 years with a history of ≥30 pack-years of smoking and who had smoked within 15 years is low cost, at approximately $1 per member per month. This assumes that 50% of these patients were screened. Such screening is also highly cost-effective, at <$19,000 per life

  6. Cost Effective Open Geometry HTS MRI System amended to BSCCO 2212 Wire for High Field Magnets

    Energy Technology Data Exchange (ETDEWEB)

    Kennth Marken

    2006-08-11

    The original goal of this Phase II Superconductivity Partnership Initiative project was to build and operate a prototype Magnetic Resonance Imaging (MRI) system using high temperature superconductor (HTS) coils wound from continuously processed dip-coated BSCCO 2212 tape conductor. Using dip-coated tape, the plan was for MRI magnet coils to be wound to fit an established commercial open geometry, 0.2 Tesla permanent magnet system. New electronics and imaging software for a prototype higher field superconducting system would have added significantly to the cost. However, the use of the 0.2 T platform would allow the technical feasibility and the cost issues for HTS systems to be fully established. Also it would establish the energy efficiency and savings of HTS open MRI compared with resistive and permanent magnet systems. The commercial goal was an open geometry HTS MRI running at 0.5 T and 20 K. This low field open magnet was using resistive normal metal conductor and its heat loss was rather high around 15 kolwatts. It was expected that an HTS magnet would dissipate around 1 watt, significantly reduce power consumption. The SPI team assembled to achieve this goal was led by Oxford Instruments, Superconducting Technology (OST), who developed the method of producing commercial dip coated tape. Superconductive Components Inc. (SCI), a leading US supplier of HTS powders, supported the conductor optimization through powder optimization, scaling, and cost reduction. Oxford Magnet Technology (OMT), a joint venture between Oxford Instruments and Siemens and the world’s leading supplier of MRI magnet systems, was involved to design and build the HTS MRI magnet and cryogenics. Siemens Magnetic Resonance Division, a leading developer and supplier of complete MRI imaging systems, was expected to integrate the final system and perform imaging trials. The original MRI demonstration project was ended in July 2004 by mutual consent of Oxford Instruments and Siemens. Between

  7. Cost Effective Open Geometry HTS MRI System amended to BSCCO 2212 Wire for High Field Magnets

    Energy Technology Data Exchange (ETDEWEB)

    Kennth Marken

    2006-08-11

    The original goal of this Phase II Superconductivity Partnership Initiative project was to build and operate a prototype Magnetic Resonance Imaging (MRI) system using high temperature superconductor (HTS) coils wound from continuously processed dip-coated BSCCO 2212 tape conductor. Using dip-coated tape, the plan was for MRI magnet coils to be wound to fit an established commercial open geometry, 0.2 Tesla permanent magnet system. New electronics and imaging software for a prototype higher field superconducting system would have added significantly to the cost. However, the use of the 0.2 T platform would allow the technical feasibility and the cost issues for HTS systems to be fully established. Also it would establish the energy efficiency and savings of HTS open MRI compared with resistive and permanent magnet systems. The commercial goal was an open geometry HTS MRI running at 0.5 T and 20 K. This low field open magnet was using resistive normal metal conductor and its heat loss was rather high around 15 kolwatts. It was expected that an HTS magnet would dissipate around 1 watt, significantly reduce power consumption. The SPI team assembled to achieve this goal was led by Oxford Instruments, Superconducting Technology (OST), who developed the method of producing commercial dip coated tape. Superconductive Components Inc. (SCI), a leading US supplier of HTS powders, supported the conductor optimization through powder optimization, scaling, and cost reduction. Oxford Magnet Technology (OMT), a joint venture between Oxford Instruments and Siemens and the world’s leading supplier of MRI magnet systems, was involved to design and build the HTS MRI magnet and cryogenics. Siemens Magnetic Resonance Division, a leading developer and supplier of complete MRI imaging systems, was expected to integrate the final system and perform imaging trials. The original MRI demonstration project was ended in July 2004 by mutual consent of Oxford Instruments and Siemens. Between

  8. A Portable Low-Cost High Density Sensor Network for Air Quality at London Heathrow Airport

    Science.gov (United States)

    Popoola, Olalekan; Mead, Iq; Bright, Vivien; Baron, Ronan; Saffell, John; Stewart, Gregor; Kaye, Paul; Jones, Roderic

    2013-04-01

    Outdoor air quality and its impact on human health and the environment have been well studied and it has been projected that poor air quality will surpass poor sanitation as the major course of environmental premature mortality by 2050 (IGAC / IGBP, release statement, 2012). Transport-related pollution has been regulated at various levels by enactment of legislations at local, national, regional and global stages. As part of the mitigation measures, routine measurements of atmospheric pollutants such as carbon monoxide (CO), nitric oxide (NO) and nitrogen dioxide (NO2) have to be established in areas where air quality problems are identified. In addition, emission inventories are also generated for different atmospheric environments including urban areas and airport environments required for air quality models. Whilst recognising that most of the existing sparse monitoring networks provide high temporal measurements, spatial data of these highly variable pollutants are not captured, making it difficult to adequately characterise the highly heterogeneous air quality. Spatial information is often obtained from model data which can only be constrained using measurements from the sparse monitoring networks. The work presented here shows the application of low-cost sensor networks aimed at addressing this missing spatial information. We have shown in previous studies the application of low-cost electrochemical sensor network instruments in monitoring road transport pollutants including CO, NO and NO2 in an urban environment (Mead et. al. 2012, accepted Atmospheric Environment). Modified versions of these instruments which include additional species such as O3, SO2, VOCs and CO2 are currently deployed at London Heathrow Airport (LHR) as part of the Sensor Network for Air Quality (SNAQ) project. Meteorology data such as temperature, relative humidity, wind speed and direction are also measured as well as size-speciated particulates (0.38 to 17.4 µm). A network of 50

  9. Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models

    Directory of Open Access Journals (Sweden)

    Rachel Ivy Anderson

    2014-02-01

    Full Text Available To examine the role of orexin-1 and orexin-2 receptor activity on ethanol self-administration, compounds that differentially target orexin (OX receptor subtypes were assessed in various self-administration paradigms using high-drinking rodent models. Effects of the OX1 antagonist SB334867, the OX2 antagonist LSN2424100, and the mixed OX1/2 antagonist almorexant (ACT-078573 on home cage ethanol consumption were tested in ethanol-preferring (P rats using a 2-bottle choice procedure. In separate experiments, effects of SB334867, LSN2424100, and almorexant on operant ethanol self-administration were assessed in P rats maintained on a progressive ratio operant schedule of reinforcement. In a third series of experiments, SB334867, LSN2424100, and almorexant were administered to ethanol-preferring C57BL/6J mice to examine effects of OX receptor blockade on ethanol intake in a binge-like drinking (drinking-in-the-dark model. In P rats with chronic home cage free-choice ethanol access, SB334867 and almorexant significantly reduced ethanol intake, but almorexant also reduced water intake, suggesting nonspecific effects on consummatory behavior. In the progressive ratio operant experiments, LSN2424100 and almorexant reduced breakpoints and ethanol consumption in P rats, whereas the almorexant inactive enantiomer and SB334867 did not significantly affect the motivation to consume ethanol. As expected, vehicle-injected mice exhibited binge-like drinking patterns in the drinking-in-the-dark model. All three OX antagonists reduced both ethanol intake and resulting blood ethanol concentrations relative to vehicle-injected controls, but SB334867 and LSN2424100 also reduced sucrose consumption in a different cohort of mice, suggesting nonspecific effects. Collectively, these results contribute to a growing body of evidence indicating that OX1 and OX2 receptor activity influences ethanol self-administration, although the effects may not be selective for ethanol

  10. Health-Related Quality of Life, Treatment Satisfaction, and Costs Associated With Intraperitoneal Versus Subcutaneous Insulin Administration in Type 1 Diabetes

    NARCIS (Netherlands)

    Logtenberg, Susan J.; Kleefstra, Nanne; Houweling, Sebastiaan T.; Groenier, Klaas H.; Gans, Reinold O.; Bilo, Henk J.

    OBJECTIVE - To investigate the effects of continuous intraperitoneal insulin infusion (CIPII) compared with subcutaneous insulin on health-related quality of life (HRQOL) and treatment satisfaction, and to perform a cost analysis in type 1 diabetes. RESEARCH DESIGN AND METHODS - We used an

  11. High Speed, Low Cost Fabrication of Gas Diffusion Electrodes for Membrane Electrode Assemblies

    Energy Technology Data Exchange (ETDEWEB)

    DeCastro, Emory S.; Tsou, Yu-Min; Liu, Zhenyu

    2013-09-20

    Fabrication of membrane electrode assemblies (MEAs) depends on creating inks or pastes of catalyst and binder, and applying this suspension to either the membrane (catalyst coated membrane) or gas diffusion media (gas diffusion electrode) and respectively laminating either gas diffusion media or gas diffusion electrodes (GDEs) to the membrane. One barrier to cost effective fabrication for either of these approaches is the development of stable and consistent suspensions. This program investigated the fundamental forces that destabilize the suspensions and developed innovative approaches to create new, highly stable formulations. These more concentrated formulations needed fewer application passes, could be coated over longer and wider substrates, and resulted in significantly lower coating defects. In March of 2012 BASF Fuel Cell released a new high temperature product based on these advances, whereby our customers received higher performing, more uniform MEAs resulting in higher stack build yields. Furthermore, these new materials resulted in an “instant” increase in capacity due to higher product yields and material throughput. Although not part of the original scope of this program, these new formulations have also led us to materials that demonstrate equivalent performance with 30% less precious metal in the anode. This program has achieved two key milestones in DOE’s Manufacturing R&D program: demonstration of processes for direct coating of electrodes and continuous in-line measurement for component fabrication.

  12. Novel concepts for low-cost and high-efficient thin film solar cells

    Science.gov (United States)

    Gómez, D.; Menéndez, A.; Sánchez, P.; Martínez, A.; Andrés, L. J.; Menéndez, M. F.; Campos, N.; García, A.; Sánchez, B.

    2011-09-01

    This work presents the activities carried out at ITMA Materials Technology related to the building integration of thin film (TF) photovoltaics (PV). Three different approaches have been developed in order to achieve high efficient solar cells at low manufacturing costs: (i) a new route for manufacturing monolithical silicon based thin film solar cells on building materials, (ii) the use of metallic nanoparticles for light trapping (plasmonic effects and light scattering) and (iii) the luminescent sol-gel coating on glass for solar concentration. In the first case, amorphous silicon modules (single junction) have been successfully manufactured at lab scale on steel and commercial ceramic substrates with efficiencies of 5.4% and 4.0%, respectively. Promising initial attempts have been also made in ethylene tetrafluoroethylene (ETFE), a polymer with high potential in textile architecture. In a similar way, the development of nanotechnology based coatings (metallic nanoparticles and luminescent materials) represent the most innovative part of the work and some preliminary results are showed.

  13. A cost for high levels of sperm competition in rodents: increased sperm DNA fragmentation.

    Science.gov (United States)

    delBarco-Trillo, Javier; García-Álvarez, Olga; Soler, Ana Josefa; Tourmente, Maximiliano; Garde, José Julián; Roldan, Eduardo R S

    2016-03-16

    Sperm competition, a prevalent evolutionary process in which the spermatozoa of two or more males compete for the fertilization of the same ovum, leads to morphological and physiological adaptations, including increases in energetic metabolism that may serve to propel sperm faster but that may have negative effects on DNA integrity. Sperm DNA damage is associated with reduced rates of fertilization, embryo and fetal loss, offspring mortality, and mutations leading to genetic disease. We tested whether high levels of sperm competition affect sperm DNA integrity. We evaluated sperm DNA integrity in 18 species of rodents that differ in their levels of sperm competition using the sperm chromatin structure assay. DNA integrity was assessed upon sperm collection, in response to incubation under capacitating or non-capacitating conditions, and after exposure to physical and chemical stressors. Sperm DNA was very resistant to physical and chemical stressors, whereas incubation in non-capacitating and capacitating conditions resulted in only a small increase in sperm DNA damage. Importantly, levels of sperm competition were positively associated with sperm DNA fragmentation across rodent species. This is the first evidence showing that high levels of sperm competition lead to an important cost in the form of increased sperm DNA damage. © 2016 The Author(s).

  14. Cost-effectiveness of surveillance programs for families at high and moderate risk of hereditary non-polyposis colorectal cancer

    DEFF Research Database (Denmark)

    Rose Olsen, Kim; Bojesen, Stig E; Gerdes, Anne-Marie M

    2007-01-01

    and moderate risk of HNPCC are offered surveillance from age 25 and age 45, respectively. The model includes costs for all families referred to genetic counseling, including genetic risk assessment, mutation analysis, and surveillance in relevant families with or without known mutation, plus the costs related...... the moderate risk group is evaluated genetically but not offered surveillance. Sensitivity analysis showed these findings to be robust, although cost-effectiveness can be improved in cases of more conservative referrals to genetic counseling. CONCLUSIONS: The result for high risk families confirms the findings...

  15. [High-dosage intralumbar methotrexate administration. A report on clinical experience].

    Science.gov (United States)

    Schöck, V

    1983-06-01

    In therapy and prophylaxis of meningeal leucemia, more than 400 injections of methotrexate, in doses between 15 mg and 50 mg (sometimes up to 75 mg) have been administered to 71 children without severe neurotoxic sequelae. This high dosage was applied repeatedly from 1970 to 1980 in 45 children suffering from acute lymphoblastic leucemia as CNS prophylaxis during a course of cobalt 60 irradiation of the skull. Since then primary CNS relapses have not been observed in these patients. The astonishing fact that these high intrathecal doses of methotrexate have been tolerated without adverse side effects may be attributed to the long intervals of at least 7 days between the individual applications.

  16. Development of an Expanded, High Reliability Cost and Performance Database for In Situ Remediation Technologies

    Science.gov (United States)

    2016-03-01

    large investment in groundwater remediation technologies more effective, end-users need quantitative, accurate, and reliable performance and cost ... technologies . The overall objective of this work was to develop a comprehensive remediation performance and cost database. N/A U U U UU 42 Travis...end-users need quantitative, accurate, and reliable performance and cost data for commonly used remediation technologies . While the data from an

  17. Synergistic methods for the production of high-strength and low-cost boron carbide

    Science.gov (United States)

    Wiley, Charles Schenck

    2011-12-01

    Boron carbide (B4C) is a non-oxide ceramic in the same class of nonmetallic hard materials as silicon carbide and diamond. The high hardness, high elastic modulus and low density of B4C make it a nearly ideal material for personnel and vehicular armor. B4C plates formed via hot-pressing are currently issued to U.S. soldiers and have exhibited excellent performance; however, hot-pressed articles contain inherent processing defects and are limited to simple geometries such as low-curvature plates. Recent advances in the pressureless sintering of B4C have produced theoretically-dense and complex-shape articles that also exhibit superior ballistic performance. However, the cost of this material is currently high due to the powder shape, size, and size distribution that are required, which limits the economic feasibility of producing such a product. Additionally, the low fracture toughness of pure boron carbide may have resulted in historically lower transition velocities (the projectile velocity range at which armor begins to fail) than competing silicon carbide ceramics in high-velocity long-rod tungsten penetrator tests. Lower fracture toughness also limits multi-hit protection capability. Consequently, these requirements motivated research into methods for improving the densification and fracture toughness of inexpensive boron carbide composites that could result in the development of a superior armor material that would also be cost-competitive with other high-performance ceramics. The primary objective of this research was to study the effect of titanium and carbon additives on the sintering and mechanical properties of inexpensive B4C powders. The boron carbide powder examined in this study was a sub-micron (0.6 mum median particle size) boron carbide powder produced by H.C. Starck GmbH via a jet milling process. A carbon source in the form of phenolic resin, and titanium additives in the form of 32 nm and 0.9 mum TiO2 powders were selected. Parametric studies of

  18. Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet.

    Science.gov (United States)

    Leontieva, Olga V; Paszkiewicz, Geraldine M; Blagosklonny, Mikhail V

    2014-08-01

    Recent discoveries have revealed the key role of mTOR (target of rapamycin) in aging. Furthermore, rapamycin extends lifespan in mice, especially in female mice. Here, we treated obese male mice on high-fat diet with rapamycin given intermittently: either weekly (once a week) or alternating bi-weekly (three injections every other week). While only marginally reducing obesity, intermittent administration of rapamycin significantly extended lifespan. Significance was achieved for weekly treated group and for the three rapamycin-received groups combined. In weekly treatment group, 100% mice were alive by the age of 2 years, whereas 60% of mice died in untreated group by this age. The effect of weekly treatment on survival was highly significant and cannot be fully explained by partial reduction in obesity. Alternating bi-weekly treatments seem to be less effective than weekly treatment, although effects of additional factors (see ) may not be excluded. After one year of treatment, all survived mice were sacrificed 8 days after the last administration of rapamycin to avoid its direct interference with parameters examined. Fasting levels of cardiac and hepatic p-S6, a marker of mTORC1 activity, were lower in weekly treatment group compared with control mice. In contrast, levels of p-Akt (S473), glucose, triglycerides and insulin were unchanged, whereas leptin and IGF-1 tended to be lower. Thus, weekly treatment with rapamycin may slow down aging in obese male mice on high-fat diet.

  19. Improving hospital cost accounting with activity-based costing.

    Science.gov (United States)

    Chan, Y C

    1993-01-01

    In this article, activity-based costing, an approach that has proved to be an improvement over the conventional costing system in product costing, is introduced. By combining activity-based costing with standard costing, health care administrators can better plan and control the costs of health services provided while ensuring that the organization's bottom line is healthy.

  20. Medical Abortion Provided by Nurse-Midwives or Physicians in a High Resource Setting: A Cost-Effectiveness Analysis.

    Directory of Open Access Journals (Sweden)

    Susanne Sjöström

    Full Text Available The objective of the present study is to calculate the cost-effectiveness of early medical abortion performed by nurse-midwifes in comparison to physicians in a high resource setting where ultrasound dating is part of the protocol. Non-physician health care professionals have previously been shown to provide medical abortion as effectively and safely as physicians, but the cost-effectiveness of such task shifting remains to be established.A cost effectiveness analysis was conducted based on data from a previously published randomized-controlled equivalence study including 1180 healthy women randomized to the standard procedure, early medical abortion provided by physicians, or the intervention, provision by nurse-midwifes. A 1.6% risk difference for efficacy defined as complete abortion without surgical interventions in favor of midwife provision was established which means that for every 100 procedures, the intervention treatment resulted in 1.6 fewer incomplete abortions needing surgical intervention than the standard treatment. The average direct and indirect costs and the incremental cost-effectiveness ratio (ICER were calculated. The study was conducted at a university hospital in Stockholm, Sweden.The average direct costs per procedure were EUR 45 for the intervention compared to EUR 58.3 for the standard procedure. Both the cost and the efficacy of the intervention were superior to the standard treatment resulting in a negative ICER at EUR -831 based on direct costs and EUR -1769 considering total costs per surgical intervention avoided.Early medical abortion provided by nurse-midwives is more cost-effective than provision by physicians. This evidence provides clinicians and decision makers with an important tool that may influence policy and clinical practice and eventually increase numbers of abortion providers and reduce one barrier to women's access to safe abortion.

  1. Medical Abortion Provided by Nurse-Midwives or Physicians in a High Resource Setting: A Cost-Effectiveness Analysis.

    Science.gov (United States)

    Sjöström, Susanne; Kopp Kallner, Helena; Simeonova, Emilia; Madestam, Andreas; Gemzell-Danielsson, Kristina

    2016-01-01

    The objective of the present study is to calculate the cost-effectiveness of early medical abortion performed by nurse-midwifes in comparison to physicians in a high resource setting where ultrasound dating is part of the protocol. Non-physician health care professionals have previously been shown to provide medical abortion as effectively and safely as physicians, but the cost-effectiveness of such task shifting remains to be established. A cost effectiveness analysis was conducted based on data from a previously published randomized-controlled equivalence study including 1180 healthy women randomized to the standard procedure, early medical abortion provided by physicians, or the intervention, provision by nurse-midwifes. A 1.6% risk difference for efficacy defined as complete abortion without surgical interventions in favor of midwife provision was established which means that for every 100 procedures, the intervention treatment resulted in 1.6 fewer incomplete abortions needing surgical intervention than the standard treatment. The average direct and indirect costs and the incremental cost-effectiveness ratio (ICER) were calculated. The study was conducted at a university hospital in Stockholm, Sweden. The average direct costs per procedure were EUR 45 for the intervention compared to EUR 58.3 for the standard procedure. Both the cost and the efficacy of the intervention were superior to the standard treatment resulting in a negative ICER at EUR -831 based on direct costs and EUR -1769 considering total costs per surgical intervention avoided. Early medical abortion provided by nurse-midwives is more cost-effective than provision by physicians. This evidence provides clinicians and decision makers with an important tool that may influence policy and clinical practice and eventually increase numbers of abortion providers and reduce one barrier to women's access to safe abortion.

  2. Introducing high-cost health care to patients: dentists' accounts of offering dental implant treatment.

    Science.gov (United States)

    Vernazza, Christopher R; Rousseau, Nikki; Steele, Jimmy G; Ellis, Janice S; Thomason, John Mark; Eastham, Jane; Exley, Catherine

    2015-02-01

    The decision-making process within health care has been widely researched, with shared decision-making, where both patients and clinicians share technical and personal information, often being cited as the ideal model. To date, much of this research has focused on systems where patients receive their care and treatment free at the point of contact (either in government-funded schemes or in insurance-based schemes). Oral health care often involves patients making direct payments for their care and treatment, and less is known about how this payment affects the decision-making process. It is clear that patient characteristics influence decision-making, but previous evidence suggests that clinicians may assume characteristics rather than eliciting them directly. The aim was to explore the influences on how dentists' engaged in the decision-making process surrounding a high-cost item of health care, dental implant treatments (DITs). A qualitative study using semi-structured interviews was undertaken using a purposive sample of primary care dentists (n = 25). Thematic analysis was undertaken to reveal emerging key themes. There were differences in how dentists discussed and offered implants. Dentists made decisions about whether to offer implants based on business factors, professional and legal obligations and whether they perceived the patient to be motivated to have treatment and their ability to pay. There was evidence that assessment of these characteristics was often based on assumptions derived from elements such as the appearance of the patient, the state of the patient's mouth and demographic details. The data suggest that there is a conflict between three elements of acting as a healthcare professional: minimizing provision of unneeded treatment, trying to fully involve patients in shared decisions and acting as a business person with the potential for financial gain. It might be expected that in the context of a high-cost healthcare intervention for which

  3. A high performance cost-effective digital complex correlator for an X-band polarimetry survey.

    Science.gov (United States)

    Bergano, Miguel; Rocha, Armando; Cupido, Luís; Barbosa, Domingos; Villela, Thyrso; Boas, José Vilas; Rocha, Graça; Smoot, George F

    2016-01-01

    The detailed knowledge of the Milky Way radio emission is important to characterize galactic foregrounds masking extragalactic and cosmological signals. The update of the global sky models describing radio emissions over a very large spectral band requires high sensitivity experiments capable of observing large sky areas with long integration times. Here, we present the design of a new 10 GHz (X-band) polarimeter digital back-end to map the polarization components of the galactic synchrotron radiation field of the Northern Hemisphere sky. The design follows the digital processing trends in radio astronomy and implements a large bandwidth (1 GHz) digital complex cross-correlator to extract the Stokes parameters of the incoming synchrotron radiation field. The hardware constraints cover the implemented VLSI hardware description language code and the preliminary results. The implementation is based on the simultaneous digitized acquisition of the Cartesian components of the two linear receiver polarization channels. The design strategy involves a double data rate acquisition of the ADC interleaved parallel bus, and field programmable gate array device programming at the register transfer mode. The digital core of the back-end is capable of processing 32 Gbps and is built around an Altera field programmable gate array clocked at 250 MHz, 1 GSps analog to digital converters and a clock generator. The control of the field programmable gate array internal signal delays and a convenient use of its phase locked loops provide the timing requirements to achieve the target bandwidths and sensitivity. This solution is convenient for radio astronomy experiments requiring large bandwidth, high functionality, high volume availability and low cost. Of particular interest, this correlator was developed for the Galactic Emission Mapping project and is suitable for large sky area polarization continuum surveys. The solutions may also be adapted to be used at signal processing

  4. A Low Cost Neutral Zinc-Iron Flow Battery with High Energy Density for Stationary Energy Storage.

    Science.gov (United States)

    Li, Xianfeng; Xie, Congxin; Duan, Yinqi; Xu, Wenbin; Zhang, Huamin

    2017-10-05

    Flow battery (FB) is one of the most promising stationary energy storage devices for storing renewable energies. However, commercial progress of the FBs is limited by their high cost and low energy density. Here we report a neutral zinc-iron FB with very low cost and high energy density. By using highly soluble FeCl2/ZnBr2 species, a charge energy density of 56.30 Wh/L can be achieved. DFT calculations demonstrated that glycine can combine with iron to suppress hydrolysis and crossover of Fe3+/Fe2+. The results indicated that an energy efficiency of 86.66% can be obtained at 40 mA/cm2 and the battery can run stably for more than 100 cycles. Furthermore, a porous membrane with low cost was employed to lower the capital cost to less than 50 $/kWh, which was the lowest value that has ever been reported. Combining the features of low cost, high energy density and high energy efficiency, the neutral zinc-iron FB becomes a promising candidate for stationary energy storage applications. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. The Influence of School Factors on Racial Opportunity Cost for High-Achieving Students of Color

    Science.gov (United States)

    Venzant Chambers, Terah T.; Huggins, Kristin Shawn

    2014-01-01

    Previous work on racial opportunity cost--that is, the price that students of color pay in their pursuit of academic success--is extended here using organizational culture literature to more closely explore the interplay of school culture with the racial opportunity cost experienced by the study participants. Eighteen African American and Latina/o…

  6. Providing strong Security and high privacy in low-cost RFID networks

    DEFF Research Database (Denmark)

    David, Mathieu; Prasad, Neeli R.

    2009-01-01

    Since the dissemination of Radio Frequency IDentification (RFID) tags is getting larger and larger, the requirement for strong security and privacy is also increasing. Low-cost and ultra-low-cost tags are being implemented on everyday products, and their limited resources constraints the security...

  7. Emergency repair of inguinal hernia in the premature infant is associated with high direct medical costs

    NARCIS (Netherlands)

    J. Verhelst (Joost); B. de Goede (Barry); B.J.H. van Kempen (Bob); H.R. Langeveld-Benders (Hester); M.J. Poley (Marten); G. Kazemier (Geert); J. Jeekel (Hans); R.M.H. Wijnen (René); J.F. Lange (Johan)

    2015-01-01

    textabstractPurpose: Inguinal hernia repair is frequently performed in premature infants. Evidence on optimal management and timing of repair, as well as related medical costs is still lacking. The objective of this study was to determine the direct medical costs of inguinal hernia, distinguishing b

  8. Subcutaneous administration of alemtuzumab in patients with highly active multiple sclerosis.

    Science.gov (United States)

    Perumal, Jai S; Foo, Farng; Cook, Perry; Khan, Omar

    2012-08-01

    Alemtuzumab is an anti-CD52 monoclonal antibody with remarkable efficacy in relapsing multiple sclerosis (MS). In clinical trials and off-label use in MS, alemtuzumab has been administered intravenously (IV). Alemtuzumab is approved for chronic lymphoid leukemia as IV. Oncology guidelines recommend alemtuzumab subcutaneous (SC) over IV. There is no report of alemtuzumab SC in MS. We report two patients with highly active relapsing MS who were treated with SC alemtuzumab, had significant improvement and tolerated SC alemtuzumab well without the typical infusion-associated adverse events. SC alemtuzumab in MS warrants further studies as this may enhance patient convenience and minimize infusion-associated adverse events.

  9. MINERALIZATION STUDY OF RENAL RATS FOLLOWING OVARYOHYSTERECTOMY AND ADMINISTRATION HIGH DOSE CALCIUM CARBONATE

    OpenAIRE

    Wiwik Misaco Yuniarti; Ira Sari Yudaniayanti; Nusdianto Triakoso

    2008-01-01

    The aim of this study was to determine the effect of high dose calcium carbonate in rat (Rattus norvegicus) following ovaryohysterectomy. A total of twenty female rats at 13 week-old were used in this study. Following ovaryohitectomy, the animals were randomized in four treatment groups. Group P0 were :fed with standard food only P1, P2 and P2 groups treated with standard food but supplemented calcium carbonate respectively at the dose of 75 mg per animal per day, 225 mg per animal per day , ...

  10. Administrator Perceptions of School Improvement Policies in a High-Impact Policy Setting

    Directory of Open Access Journals (Sweden)

    MARIO S. TORRES

    2008-10-01

    Full Text Available This study investigated school administrators’ perceptions of school improvement policies in a high-impact policy environment by measuring the impact of accountability, site-based management, professional development, and scheduling reform on the three dependent variables of a academic outcomes, b staff morale, and c parent and community involvement. Using a convenience sampling method, 49 public school principals from Texas participated and an online survey was constructed to gather both quantitative (i.e., Likert scale and qualitative (i.e., open ended response data. The findings clearly point to principals, regardless of geographical district type and grade level school type, viewing less controversial and more intrinsically oriented policies (i.e., site-based management and professional development as having a greater positive impact on outcomes as a whole than more radical alternatives (i.e., accountability and time and schedule reform. The evidence suggests that more aggressive school improvement policy approaches are likely failing to generate enough convincing outcomes to generate high commitment and confidence from school leaders. Further studies may look at the interaction of policy impact with minority student enrollments and with subgroup populations.

  11. Low Cost Automated Module Assembly for 180 GHz Devices Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Despite the obvious advantages of millimeter wave technology, a major barrier to expanded use is high assembly costs due to: need for specialized equipments; need...

  12. Reduced Cost Composite Hot Structures with Oxidation Protection Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Innovative, low cost high performance technologies are critical to the affordability of future space missions. Carbon/carbon (C/C) composites have significant...

  13. Chronic Administration of High Doses of Nandrolone Decanoate on the Pituitary-Gonadal Axis in Male Rats

    Directory of Open Access Journals (Sweden)

    Shahraki

    2015-09-01

    Full Text Available Background Anabolic-androgenic steroids (AAS are abused by athletes. Objectives The present study was designed to evaluate chronic administration of high doses of nandrolone decanoate (ND on the pituitary-gonadal axis and hematological parameters in normal male rats. Materials and Methods Thirty Wistar-Albino male rats were divided assigned to control (C, placebo (P and test (T groups (n = 10. Group T received 15 mg/kg intramuscular (IM ND for eight weeks. Group P received the same volume of peanut oil, but group C did not receive any agent during the trial period. At the end, animals were anesthetized, killed and blood samples collected from cervical vessels. Serum follicle stimulating hormone (FSH and luteinizing hormone (LH levels were determined by sensitive rat gonadotropins kit, using ELISA methods. Serum testosterone and hematological parameters were measured by ordinary laboratory methods. Obtained data was analyzed using SPSS 17 by ANOVA and Tukey statistical tests. Results were expressed as Mean ± SD. Statistical difference considered significantly by P < 0.05. Results Serum testosterone, LH, FSH, weight gain, food and water intake in group T were significantly decreased compared to other groups (P < 0.05. In addition erythrocyte, leucocytes, hemoglobin and hematocrit in group T were significantly increased compared to those of other groups (P < 0.05. Conclusions Chronic administration of high doses of ND can alter serum FSH, LH and testosterone and hematological parameters in male rats.

  14. Cost-benefit evaluation of a preventive intervention on the biological risk in health: the accidental puncture during the administration of insulin in the University Hospital "Federico II" of Naples.

    Science.gov (United States)

    Montella, E; Schiavone, D; Apicella, L; Di Silverio, P; Gaudiosi, M; Ambrosone, E; Moscaritolo, E; Triassi, M

    2014-01-01

    The occupational exposure to biological risk is a frequent event that affects millions of workers in the health sector. Operators are exposed to accidental contact with blood and other potentially infectious biological materials with a frequency higher than that observed in the population (occupational exposure). The pathogens most frequently implicated are the human immunodeficiency virus (HIV), hepatitis C (HCV) and hepatitis B (HBV) viruses. The World Health Organization estimates that each year more than 3 million health workers hurt themselves with an object/edge definitely contaminated with at least one HIV (about 170,000 exposures), hepatitis B (approximately 2,000,000 exposures) and hepatitis C (approximately 900,000 exposures). In Italy approximately 100,000 percutaneous exposures/year are estimated to take place. The needlestick injuries in health care workers are, in large part, preventable by adopting measures such as the use of instrumental needlesticks Prevention Devices - NPDs. The adoption of the NPDs is extremely effective in reducing occupational exposure to biological risk (from 63 % to 100 % reduction). The aim of this study was to evaluate whether the adoption of NPDs for insulin therapy is costeffective in terms of prevention of accidents by Biohazard, compared to administration of insulin with traditional methods (syringe + vial). The estimation is carried out both in the light of current legislation (European Directive 2010/32 and 81/08 Italian Law) and epidemiological data and cost of accidents (according to frequency) and alternative interventions. The evaluation of cost-effectiveness included the construction of an economic model that would allow the weighting of the costs of accidents that can occur following the administration of insulin therapy with traditional methods. The economic model was developed taking into account the international literature on the phenomenon of "accidental puncture" and allowed the financial quantification of

  15. Reduction of electricity comsumption during 'high cost' periods in winter 2005 - 2006

    CERN Multimedia

    Mario Batz

    2005-01-01

    In previous years CERN was able to limit its electricity consumption during the winter months sufficiently to be supplied from the Swiss grid. In order to make enough power available for the LHC machine and experiments at the lowest possible cost during the coming winter 2005 / 2006 CERN is supplied from the French grid by EDF (Electricité de France). As a consequence, when the grids are at peak demand during the tariff period 'Effacement Jour de Pointe' (EJP) in France, the energy price is at least four times as high as for the usual winter period. From 1st November until 31st March these increased prices are applicable during twenty-two 18-hour periods, each beginning at 7 a.m. and ending at 1 a.m. the following day. Notice will be given by EDF to the Technical Infrastructure Control Room (TI) at 5 p.m. the previous day. The notice period may be reduced to two hours for days following weekends and public holidays, or omitted entirely for technical reasons. During these days of EJP CERN has a strong fina...

  16. Final Report for Project titled High Thermal Conductivity Polymer Composites for Low-Cost Heat Exchangers

    Energy Technology Data Exchange (ETDEWEB)

    Thibaud-Erkey, Catherine [United Technologies reserach Center, East Hartford, CT (United States); Alahyari, Abbas [United Technologies reserach Center, East Hartford, CT (United States)

    2016-12-28

    Heat exchangers (HXs) are critical components in a wide range of heat transfer applications, from HVAC (Heating Ventilation and Cooling) to automobiles to manufacturing plants. They require materials capable of transferring heat at high rates while also minimizing thermal expansion over the usage temperature range. Conventionally, metals are used for applications where effective and efficient heat exchange is required, since many metals exhibit thermal conductivity over 100 W/m K. While metal HXs are constantly being improved, they still have some inherent drawbacks due to their metal construction, in particular corrosion. Polymeric material can offer solution to such durability issues and allow designs that cannot be afforded by metal construction either due to complexity or cost. A major drawback of polymeric material is their low thermal conductivity (0.1-0.5? W/mK) that would lead to large system size. Recent improvements in the area of filled polymers have highlighted the possibility to greatly improve the thermal conductivity of polymeric materials while retaining their inherent manufacturing advantage, and have been applied to heat sink applications. Therefore, the objective of this project was to develop a robust review of materials for the manufacturing of industrial and commercial non-metallic heat exchangers. This review consisted of material identification, literature evaluation, as well as empirical and model characterization, resulting in a database of relevant material properties and characteristics to provide guidance for future heat exchanger development.

  17. A highly sensitive, low-cost, wearable pressure sensor based on conductive hydrogel spheres

    KAUST Repository

    Tai, Yanlong

    2015-01-01

    Wearable pressure sensing solutions have promising future for practical applications in health monitoring and human/machine interfaces. Here, a highly sensitive, low-cost, wearable pressure sensor based on conductive single-walled carbon nanotube (SWCNT)/alginate hydrogel spheres is reported. Conductive and piezoresistive spheres are embedded between conductive electrodes (indium tin oxide-coated polyethylene terephthalate films) and subjected to environmental pressure. The detection mechanism is based on the piezoresistivity of the SWCNT/alginate conductive spheres and on the sphere-electrode contact. Step-by-step, we optimized the design parameters to maximize the sensitivity of the sensor. The optimized hydrogel sensor exhibited a satisfactory sensitivity (0.176 ΔR/R0/kPa-1) and a low detectable limit (10 Pa). Moreover, a brief response time (a few milliseconds) and successful repeatability were also demonstrated. Finally, the efficiency of this strategy was verified through a series of practical tests such as monitoring human wrist pulse, detecting throat muscle motion or identifying the location and the distribution of an external pressure using an array sensor (4 × 4). © 2015 The Royal Society of Chemistry.

  18. Simple and cost-effective fabrication of highly flexible, transparent superhydrophobic films with hierarchical surface design.

    Science.gov (United States)

    Kim, Tae-Hyun; Ha, Sung-Hun; Jang, Nam-Su; Kim, Jeonghyo; Kim, Ji Hoon; Park, Jong-Kweon; Lee, Deug-Woo; Lee, Jaebeom; Kim, Soo-Hyung; Kim, Jong-Man

    2015-03-11

    Optical transparency and mechanical flexibility are both of great importance for significantly expanding the applicability of superhydrophobic surfaces. Such features make it possible for functional surfaces to be applied to various glass-based products with different curvatures. In this work, we report on the simple and potentially cost-effective fabrication of highly flexible and transparent superhydrophobic films based on hierarchical surface design. The hierarchical surface morphology was easily fabricated by the simple transfer of a porous alumina membrane to the top surface of UV-imprinted polymeric micropillar arrays and subsequent chemical treatments. Through optimization of the hierarchical surface design, the resultant superhydrophobic films showed superior surface wetting properties (with a static contact angle of >170° and contact angle hysteresis of 82% at 550 nm wavelength). The superhydrophobic films were also experimentally found to be robust without significant degradation in the superhydrophobicity, even under repetitive bending and pressing for up to 2000 cycles. Finally, the practical usability of the proposed superhydorphobic films was clearly demonstrated by examining the antiwetting performance in real time while pouring water on the film and submerging the film in water.

  19. Organic/IR-Semiconductor heterojunctions for low-cost, high temperature IR arrays

    Science.gov (United States)

    Jones, Colin E.

    1992-08-01

    This program evaluated a new technology for producing infrared photo-diodes in HgCdTe and InSb using evaporated organic heterojunctions. High quantum-efficiency IR detectors were demonstrated with the organic process comparable to commercial IR detectors. The organic photodiodes at room temperature were better than commercial detectors. They had lower leakage currents and higher resistance-area products (RoAs). Detector arrays made with the organics can operate at higher temperatures than the current detectors. Initial data at low temperatures were poorer than commercial detectors with lower RoAs and slightly higher 1/f noise. This comparison at low temperature may change with further optimization of the organic process. The organic diode process is very simple, low cost and non-damaging to the HgCdTe or InSb. It involves thermal evaporation of the organic onto the HgCdTe or InSb followed by evaporation of metal contacts through a shadow mask. Phase 1 demonstrated organic/HaCdTe IR detectors with quantum efficiencies similar to commercial devices operating at higher temperatures. The technology is ready for a Phase 2 to further optimize the processing for IR arrays and to increase yields.

  20. A highly sensitive, low-cost, wearable pressure sensor based on conductive hydrogel spheres.

    Science.gov (United States)

    Tai, Yanlong; Mulle, Matthieu; Aguilar Ventura, Isaac; Lubineau, Gilles

    2015-09-21

    Wearable pressure sensing solutions have promising future for practical applications in health monitoring and human/machine interfaces. Here, a highly sensitive, low-cost, wearable pressure sensor based on conductive single-walled carbon nanotube (SWCNT)/alginate hydrogel spheres is reported. Conductive and piezoresistive spheres are embedded between conductive electrodes (indium tin oxide-coated polyethylene terephthalate films) and subjected to environmental pressure. The detection mechanism is based on the piezoresistivity of the SWCNT/alginate conductive spheres and on the sphere-electrode contact. Step-by-step, we optimized the design parameters to maximize the sensitivity of the sensor. The optimized hydrogel sensor exhibited a satisfactory sensitivity (0.176 ΔR/R0/kPa(-1)) and a low detectable limit (10 Pa). Moreover, a brief response time (a few milliseconds) and successful repeatability were also demonstrated. Finally, the efficiency of this strategy was verified through a series of practical tests such as monitoring human wrist pulse, detecting throat muscle motion or identifying the location and the distribution of an external pressure using an array sensor (4 × 4).

  1. Wastewater treatment high rate algal ponds (WWT HRAP) for low-cost biofuel production.

    Science.gov (United States)

    Mehrabadi, Abbas; Craggs, Rupert; Farid, Mohammed M

    2015-05-01

    Growing energy demand and water consumption have increased concerns about energy security and efficient wastewater treatment and reuse. Wastewater treatment high rate algal ponds (WWT HRAPs) are a promising technology that could help solve these challenges concurrently where climate is favorable. WWT HRAPs have great potential for biofuel production as a by-product of WWT, since the costs of algal cultivation and harvest for biofuel production are covered by the wastewater treatment function. Generally, 800-1400 GJ/ha/year energy (average biomass energy content: 20 GJ/ton; HRAP biomass productivity: 40-70 tons/ha/year) can be produced in the form of harvestable biomass from WWT HRAP which can be used to provide community-level energy supply. In this paper the benefits of WWT HRAPs are compared with conventional mass algal culture systems. Moreover, parameters to effectively increase algal energy content and overall energy production from WWT HRAP are discussed including selection of appropriate algal biomass biofuel conversion pathways.

  2. A High Earth, Lunar Resonant Orbit for Lower Cost Space Science Missions

    CERN Document Server

    Gangestad, Joseph W; Persinger, Randy R; Ricker, George R

    2013-01-01

    NASA astrophysics robotic science missions often require continuous, unobstructed fields-of view (FOV) of the celestial sphere and orbits that provide stable thermal- and attitude-control environments. To date, the more expensive "flagship" missions use the second Earth/Sun Lagrange point (L2) approximately 1.5 million km from the Earth outside the orbit of the Moon or a "drift away" orbit to distances >10 million km. A High Earth Orbit (HEO) offers similar advantages with regard to continuous, unobstructed FOV and a thermally stable environment with minimal station-keeping requirements. The "P/2-HEO," an orbit in 2:1 resonance with the orbit of the Moon, also provides the opportunity for data downlink at orbit perigee distances close to the Earth allowing for lower-cost communications systems. The P/2-HEO oscillates on the order of 12 years and trades orbit eccentricity for orbit inclination. This orbit variability can be selected for optimum spacecraft performance by proper choice of the conditions using a ...

  3. A Low-Cost, High-Performance System for Fluorescence Lateral Flow Assays

    Directory of Open Access Journals (Sweden)

    Linda G. Lee

    2013-10-01

    Full Text Available We demonstrate a fluorescence lateral flow system that has excellent sensitivity and wide dynamic range. The illumination system utilizes an LED, plastic lenses and plastic and colored glass filters for the excitation and emission light. Images are collected on an iPhone 4. Several fluorescent dyes with long Stokes shifts were evaluated for their signal and nonspecific binding in lateral flow. A wide range of values for the ratio of signal to nonspecific binding was found, from 50 for R-phycoerythrin (R-PE to 0.15 for Brilliant Violet 605. The long Stokes shift of R-PE allowed the use of inexpensive plastic filters rather than costly interference filters to block the LED light. Fluorescence detection with R-PE and absorbance detection with colloidal gold were directly compared in lateral flow using biotinylated bovine serum albumen (BSA as the analyte. Fluorescence provided linear data over a range of 0.4–4,000 ng/mL with a 1,000-fold signal change while colloidal gold provided non-linear data over a range of 16–4,000 ng/mL with a 10-fold signal change. A comparison using human chorionic gonadotropin (hCG as the analyte showed a similar advantage in the fluorescent system. We believe our inexpensive yet high-performance platform will be useful for providing quantitative and sensitive detection in a point-of-care setting.

  4. Evaluation of low-cost cathode catalysts for high yield biohydrogen production in microbial electrolysis cell.

    Science.gov (United States)

    Wang, L; Chen, Y; Ye, Y; Lu, B; Zhu, S; Shen, S

    2011-01-01

    As an ideal fuel due to the advantages of no pollution, high combustion heat and abundant sources, hydrogen gas can be produced from organic matter through the electrohydrogenesis process in microbial electrolysis cells. But in many MECs, platinum is often used as catalyst, which limits the practical applications of MECs. To reduce the cost of the MECs, Ni-based alloy cathodes were developed by electrodepositing. In this paper hydrogen production using Ni-W-P cathode was studied for the first time in a single-chamber membrane-free MEC. At an applied voltage of 0.9 V, MECs with Ni-W-P cathodes obtained a hydrogen production rate of 1.09 m3/m3/day with an cathodic hydrogen recovery of 74%, a Coulombic efficiency of 56% and an electrical energy efficiency relative to electrical input of 139%, which was the best result of reports in this study. The Ni-W-P cathode demonstrated a better electrocatalytic activity than the Ni-Ce-P cathode and achieved a comparable performance to the Pt cathode in terms of hydrogen production rate, Coulombic efficiency, cathodic hydrogen recovery and electrical energy efficiency at 0.9 V.

  5. High SO{sub 2} removal duct injection: A low-cost FGD alternative

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, S.G. [Sorbent Technologies Corp., Twinsburg, OH (United States)

    1995-12-01

    Sorbent Technologies Corporation, of the United States, is currently developing and demonstrating a new waste free, retrofitable, high-SO{sub 2} removal duct-injection process. Up to 85 percent SO{sub 2} removal is achieved by simply injecting a new dry lime-based sorbent into the flue-gas duct, collecting the sorbent downstream in a particulate collector, and then recycling the sorbent. By avoiding large, expensive components, the process can have low capital costs, making it especially appropriate for smaller, older, less-utilized plants. The key to the new technology is the use of sorbent supports. Supported sorbents are produced by coating hydrated lime onto inexpensive mineral supports, such as exfoliated vermiculite or perlite. Consequently, there are no liquid, sludge, or solid wastes with the new technology. Once saturated with SO{sub 2}, the spent sorbent can be easily pelletized into a valuable soil-conditioning agricultural by-product, for the sustainable development that the future requires. This paper describes Sorbent Technologies` pilot demonstration of supported sorbent injection at the Ohio Edison Company`s R.E. Burger station. The Burger effort is also the first demonstration of the Electric Power Research Institute`s new {open_quotes}COHPAC{close_quotes} baghouse technology in a sorbent-injection desulfurization application.

  6. MASS PRODUCTION OF NANOPARTICLES BY HIGH GRAVITY REACTIVE PRECIPITATION TECHNOLOGY WITH LOW COST

    Institute of Scientific and Technical Information of China (English)

    Jianfeng Chen; Lei Shao

    2003-01-01

    Mass production of nanoparticles at low cost has attracted much attention from industrial and academic circles. In this paper, a novel method, the high gravity reactive precipitation (HGRP) technology, of manufacturing CaCO3 nanoparticles, presently scaled-up to an annual capacity of 10,000 tons, is presented. This paper describes the process principle, the process design and experiments on the syntheses of 15-30 nm CaCO3, 30-50 nm SiO2,20-30 nm TiO2, 20-60 nm ZnO, 20-30 nm ZnS, 30 nm SrCO3, 40-70 nm BaTiO3, stick-like nano BaCO3 as well as nano-fibrillar aluminum hydroxide measuring 1-10 nm in diameter and 50-300 nm in length, using liquid-liquid,gas-liquid and gas-liquid-solid reactant systems. The advantage of using the HGRP technology is illustrated by comparison to conventional methods.

  7. A Low Cost, High Capacity Regenerable Sorbent for Pre-combustion CO{sub 2} Capture

    Energy Technology Data Exchange (ETDEWEB)

    Alptekin, Gokhan

    2012-09-30

    The overall objective of the proposed research is to develop a low cost, high capacity CO{sub 2} sorbent and demonstrate its technical and economic viability for pre-combustion CO{sub 2} capture. The specific objectives supporting our research plan were to optimize the chemical structure and physical properties of the sorbent, scale-up its production using high throughput manufacturing equipment and bulk raw materials and then evaluate its performance, first in bench-scale experiments and then in slipstream tests using actual coal-derived synthesis gas. One of the objectives of the laboratory-scale evaluations was to demonstrate the life and durability of the sorbent for over 10,000 cycles and to assess the impact of contaminants (such as sulfur) on its performance. In the field tests, our objective was to demonstrate the operation of the sorbent using actual coal-derived synthesis gas streams generated by air-blown and oxygen-blown commercial and pilot-scale coal gasifiers (the CO{sub 2} partial pressure in these gas streams is significantly different, which directly impacts the operating conditions hence the performance of the sorbent). To support the field demonstration work, TDA collaborated with Phillips 66 and Southern Company to carry out two separate field tests using actual coal-derived synthesis gas at the Wabash River IGCC Power Plant in Terre Haute, IN and the National Carbon Capture Center (NCCC) in Wilsonville, AL. In collaboration with the University of California, Irvine (UCI), a detailed engineering and economic analysis for the new CO{sub 2} capture system was also proposed to be carried out using Aspen PlusTM simulation software, and estimate its effect on the plant efficiency.

  8. Final Technical Report - Recovery Act: Organic Coatings as Encapsulants for Low Cost, High Performance PV Modules

    Energy Technology Data Exchange (ETDEWEB)

    Stuart Hellring; Jiping Shao; James Poole

    2011-12-05

    The objective of this project was to evaluate the feasibility of utilizing PPG's commercial organic coatings systems as efficient, modernized encapsulants for low cost, high performance, thin film photovoltaic modules. Our hypothesis was that the combination of an anticorrosive coating with a more traditional barrier topcoat would mitigate many electrochemical processes that are now responsible for the significant portion of photovoltaic (PV) failures, thereby nullifying the extremely high moisture barrier requirements of currently used encapsulation technology. Nine commercially available metal primer coatings and six commercially available top coatings were selected for screening. Twenty-one different primer/top coat combinations were evaluated. The primer coatings were shown to be the major contributor to corrosion inhibition, adhesion, and barrier properties. Two primer coatings and one top coating were downselected for testing on specially-fabricated test modules. The coated test modules passed initial current leakage and insulation testing. Damp Heat testing of control modules showed visible corrosion to the bus bar metal, whereas the coated modules showed none. One of the primer/top coat combinations retained solar power performance after Damp Heat testing despite showing some delamination at the EVA/solar cell interface. Thermal Cycling and Humidity Freeze testing resulted in only one test module retaining its power performance. Failure modes depended on the particular primer/top coating combination used. Overall, this study demonstrated that a relatively thin primer/top coating has the potential to replace the potting film and backsheet in crystalline silicon-based photovoltaic modules. Positive signals were received from commercially available coatings developed for applications having performance requirements different from those required for photovoltaic modules. It is likely that future work to redesign and customize these coatings would result in

  9. A Low-cost, High-yield Process for the Direct Productin of High Energy Density Liquid Fuel from Biomass

    Energy Technology Data Exchange (ETDEWEB)

    Agrawal, Rakesh

    2014-02-21

    The primary objective and outcome of this project was the development and validation of a novel, low-cost, high-pressure fast-hydropyrolysis/hydrodeoxygenation (HDO) process (H{sub 2}Bioil) using supplementary hydrogen (H{sub 2}) to produce liquid hydrocarbons from biomass. The research efforts under the various tasks of the project have culminated in the first experimental demonstration of the H2Bioil process, producing 100% deoxygenated >C4+ hydrocarbons containing 36-40% of the carbon in the feed of pyrolysis products from biomass. The demonstrated H{sub 2}Bioil process technology (i.e. reactor, catalyst, and downstream product recovery) is scalable to a commercial level and is estimated to be economically competitive for the cases when supplementary H{sub 2} is sourced from coal, natural gas, or nuclear. Additionally, energy systems modeling has revealed several process integration options based on the H{sub 2}Bioil process for energy and carbon efficient liquid fuel production. All project tasks and milestones were completed or exceeded. Novel, commercially-scalable, high-pressure reactors for both fast-hydropyrolysis and hydrodeoxygenation were constructed, completing Task A. These reactors were capable of operation under a wide-range of conditions; enabling process studies that lead to identification of optimum process conditions. Model compounds representing biomass pyrolysis products were studied, completing Task B. These studies were critical in identifying and developing HDO catalysts to target specific oxygen functional groups. These process and model compound catalyst studies enabled identification of catalysts that achieved 100% deoxygenation of the real biomass feedstock, sorghum, to form hydrocarbons in high yields as part of Task C. The work completed during this grant has identified and validated the novel and commercially scalable H2Bioil process for production of hydrocarbon fuels from biomass. Studies on model compounds as well as real biomass

  10. Extended exenatide administration enhances lipid metabolism and exacerbates pancreatic injury in mice on a high fat, high carbohydrate diet.

    Directory of Open Access Journals (Sweden)

    Rodney Rouse

    Full Text Available This study expanded upon a previous study in mice reporting a link between exenatide treatment and exocrine pancreatic injury by demonstrating temporal and dose responses and providing an initial mechanistic hypothesis. The design of the present study included varying lengths of exenatide exposure (3, 6 weeks to 12 weeks at multiple concentrations (3, 10, or 30 µg/kg with multiple endpoints (histopathology evaluations, immunoassay for cytokines, immunostaining of the pancreas, serum chemistries and measurement of trypsin, amylase, and, lipase, and gene expression profiles. Time- and dose-dependent exocrine pancreatic injury was observed in mice on a high fat diet treated with exenatide. The morphological changes identified in the pancreas involved acinar cell injury and death (autophagy, apoptosis, necrosis, and atrophy, cell adaptations (hypertrophy and hyperplasia, and cell survival (proliferation/regeneration accompanied by varying degrees of inflammatory response leading to secondary injury in pancreatic blood vessels, ducts, and adipose tissues. Gene expression profiles indicated increased signaling for cell survival and altered lipid metabolism in exenatide treated mice. Immunohistochemistry supported gene expression findings that exenatide caused and/or exacerbated pancreatic injury in a high fat diet environment potentially by further increasing high fat diet exacerbated lipid metabolism and resulting oxidative stress. Further investigation is required to confirm these findings and determine their relevance to human disease.

  11. The Aragoscope: Ultra-High Resolution Optics at Low Cost Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The diagram shows a conventional telescope pointed at an opaque disk along an axis to a distant target. Rather than block the view, the disk boosts the resolution of...

  12. Nano-Enabled Low-Cost High-Performance UV Anti-Reflection Coatings Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this program, Agiltron and the groups of Professors Rubner and Cohen at MIT propose a novel nano-porous coating for next generation NASA UV anti-reflection (AR)...

  13. Low-Cost Small Payload Return to Enable High Frequency ISS Research Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Terminal Velocity Aerospace, LLC (TVA) proposes to improve utilization of the International Space Station (ISS) by providing a system for on-demand return of...

  14. High Efficiency Solar Cell on Low Cost Metal Foil Substrate Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Future space missions will require Solar cell arrays having specific power ratings in excess of 1000 W/kg. Conventional crystalline photovoltaic technology comprised...

  15. Nano-Enabled Low-Cost High-Performance UV Anti-Reflection Coatings Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Agiltron together with Prof. Michael Rubner's group at MIT is developing a new family of nanoporous, low refractive index coatings for next generation NASA UV...

  16. Low-Cost High-Performance Hall Thruster Support System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Colorado Power Electronics is in the process of completing NASA SBIR contract NNC07CA12C Wide Output Range Power Processing Unit for Electric Propulsion. At the end...

  17. Low Cost, High Efficiency, Pressurization System for Responsive Launch Operations Project

    Data.gov (United States)

    National Aeronautics and Space Administration — KT Engineering (KTE) is pleased to submit this proposal to address the stated need for "innovative solutions that will allow spaceport launch service providers to...

  18. Advanced Materials and Manufacturing for Low-Cost, High-Performance Liquid Rocket Combustion Chambers Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Silicided niobium alloy (C103) combustion chambers have been used extensively in both NASA and DoD liquid rocket propulsion systems. Niobium alloys offer a good...

  19. MINERALIZATION STUDY OF RENAL RATS FOLLOWING OVARYOHYSTERECTOMY AND ADMINISTRATION HIGH DOSE CALCIUM CARBONATE

    Directory of Open Access Journals (Sweden)

    Wiwik Misaco Yuniarti

    2008-06-01

    Full Text Available The aim of this study was to determine the effect of high dose calcium carbonate in rat (Rattus norvegicus following ovaryohysterectomy. A total of twenty female rats at 13 week-old were used in this study. Following ovaryohitectomy, the animals were randomized in four treatment groups. Group P0 were :fed with standard food only P1, P2 and P2 groups treated with standard food but supplemented calcium carbonate respectively at the dose of 75 mg per animal per day, 225 mg per animal per day , and 450 mg per animal per day. The calcium carbonate supplement were given daily in the morning for 42 days. The experimental animals were sacrificed at 21 week-old. Calcium and phosphor level in sinister kidneys were determined by spectrofotometric method. The data obtained from this study were analysed using one way analysis of variance. No significant difference was observed in calcium level among four treatment groups, with the lowest level were found in P3 group. However, the phosphor level of P1 was significantly lower than those of P2 and P3 groups. The highest phosphor level was observed in P3 group, indicating a phosphorous retension and the signs of renal failure.

  20. A ceramic drug delivery vehicle for oral administration of highly potent opioids.

    Science.gov (United States)

    Forsgren, Johan; Jämstorp, Erik; Bredenberg, Susanne; Engqvist, Håkan; Strømme, Maria

    2010-01-01

    Pellets composed of the ceramic material Halloysite and microcrystalline cellulose were synthesized with the aim of producing a drug delivery vehicle for sustained release of the opioid Fentanyl with low risk for dose dumping at oral intake of the highly potent drug. Drug release profiles of intact and crushed pellets, to simulate swallowing without or with chewing, in pH 6.8, pH 1, and in 48% ethanol were recorded in order to replicate the conditions in the small intestines, in the stomach, as well as cointake of the drug with alcohol. The drug release was analyzed by employing the Weibull equation, which showed that the release profiles were either governed by fickian diffusion (intact pellets in pH 6.8 and in ethanol) or by diffusion in a fractal or disordered pore network (intact pellets in pH 1 and crushed pellets in all solutions). A sustained release for approximately 3-4 h was obtained in all studied solutions from intact pellets, whereas crushed pellets released the drug content during approximately 2-3 h. The finding that a sustained release profile could be obtained both in alcohol and after crushing of the pellets, shows that the ceramic carrier under investigation, at least to some extent, hampers dose dumping, and may thus be a promising material in future developments of new opioid containing oral dosage forms.