Sample records for hidetoshi matsui tottori

  1. Epidemiological Survey of Frontotemporal Lobar Degeneration in Tottori Prefecture, Japan

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    Kenji Wada-Isoe


    Full Text Available Background: The prevalence of frontotemporal lobar degeneration (FTLD in Japan is unknown. An epidemiological survey study of FTLD was undertaken in Tottori Prefecture, a district in the western region of Japan. Methods: Hospitals in Tottori Prefecture were surveyed by a two-step questionnaire in 2010, and the prevalence of FTLD per 100,000 inhabitants was calculated using the actual number of patients and inhabitants in Tottori Prefecture on the prevalence day of October 1, 2010. Results: In this survey, 66 patients were diagnosed with FTLD. The subtypes of FTLD were as follows: 62 cases of frontotemporal dementia (FTD, 3 cases of progressive nonfluent aphasia, and 1 case of semantic dementia. Among the FTD cases, 5 cases were FTD with motor neuron disease and 1 case was FTD with parkinsonism linked to chromosome 17. The prevalence of FTD in the total population of Tottori Prefecture was 11.2 per 100,000 inhabitants. Based on these results, the prevalence of FTLD in Japan in 2008 was estimated to be 9.5 per 100,000 individuals. Conclusions: Our epidemiological survey results suggest that there are at least 12,000 FTLD patients in Japan, indicating that FTLD is not a rare disease.

  2. Differential energy radiation from two earthquakes in Japan with identical Mw: The Kyushu 1996 and Tottori 2000 earthquakes (United States)

    Choy, G.L.; Boatwright, J.


    We examine two closely located earthquakes in Japan that had identical moment magnitudes Mw but significantly different energy magnitudes Me. We use teleseismic data from the Global Seismograph Network and strong-motion data from the National Research Institute for Earth Science and Disaster Prevention's K-Net to analyze the 19 October 1996 Kyushu earthquake (Mw 6.7, Me 6.6) and the 6 October 2000 Tottori earthquake (Mw 6.7, Me 7.4). To obtain regional estimates of radiated energy ES we apply a spectral technique to regional (earthquake, we estimate an average regional attenuation Q(f) 230f0:65. For the strike-slip Tottori earthquake, the average regional attenuation is Q(f) 180f0:6. These attenuation functions are similar to those derived from studies of both California and Japan earthquakes. The regional estimate of ES for the Kyushu earthquake, 3:8 ?? 1014 J, is significantly smaller than that for the Tottori earthquake, ES 1:3 ?? 1015 J. These estimates correspond well with the teleseismic estimates of 3:9 ?? 1014 J and 1:8 ?? 1015 J, respectively. The apparent stress (Ta = ??Es/M0 with ?? equal to rigidity) for the Kyushu earthquake is 4 times smaller than the apparent stress for the Tottori earthquake. In terms of the fault maturity model, the significantly greater release of energy by the strike-slip Tottori earthquake can be related to strong deformation in an immature intraplate setting. The relatively lower energy release of the thrust-fault Kyushu earthquake can be related to rupture on mature faults at a subduction environment. The consistence between teleseismic and regional estimates of ES is particularly significant as teleseismic data for computing ES are routinely available for all large earthquakes whereas often there are no near-field data.

  3. Distribution characteristics of Rn-222 concentrations on Misasa spa district, Tottori Pref., JAPAN

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    Koga, T.; Morishima, H.; Inagaki, M.; Tanaka, Y.; Mifune, M. [Kinki Univ., Fuse, Osaka (Japan). Atomic Energy Research Inst


    We have carried out convenient and highly sensitive radon measurement using absorption to means of a detecting active charcoal and a liquid scintillation spectrometer, Packard Pico-rad System. The {alpha} and {beta} radioactivities of its decay products originated from radon gas absorbed detector exposed to air were measured. Its detection limit is 1.7Bq/m{sup 3} in air with an accuracy of about 10% on 200 minutes of counting time, and correction coefficient, the ratio of measured radon concentration to standard radon concentration (about 300Bq/m{sup 3}) is 0.75 on the standard radon gas chamber of Japan Nuclear Cycle Development Institute. Misasa district, Tottori pref. is famous for the radioactive spa in Japan. We have measured the Rn-222 concentrations in air with a set of indoor and outdoor. The distribution range of Rn-222 concentrations in air on Misasa spa district from 1995 to 1998 are 8 - 194Bq/m{sup 3} indoors, 2 - 150Bq/m{sup 3} outdoors, the former generally are higher than those outdoor and these ratios fluctuate on the range 1.1 - 2.3. Rn-222 concentrations in air on Asahi, Takeda and Misasa districts geologically formed from granite strata were higher than those on Mitoku and Osika districts formed from volcanic rocks (Andesite and Basalt), and its ratio of indoor to outdoor were similar trend too. The strata is also a influence on Rn-222 concentration in air. The Rn-222 concentrations on Higashi-osaka as control area are 4.9 - 17Bq/m{sup 3} indoors and 0.33 - 10Bq/m{sup 3} outdoors. (author)

  4. A global search inversion for earthquake kinematic rupture history: Application to the 2000 western Tottori, Japan earthquake (United States)

    Piatanesi, A.; Cirella, A.; Spudich, P.; Cocco, M.


    We present a two-stage nonlinear technique to invert strong motions records and geodetic data to retrieve the rupture history of an earthquake on a finite fault. To account for the actual rupture complexity, the fault parameters are spatially variable peak slip velocity, slip direction, rupture time and risetime. The unknown parameters are given at the nodes of the subfaults, whereas the parameters within a subfault are allowed to vary through a bilinear interpolation of the nodal values. The forward modeling is performed with a discrete wave number technique, whose Green's functions include the complete response of the vertically varying Earth structure. During the first stage, an algorithm based on the heat-bath simulated annealing generates an ensemble of models that efficiently sample the good data-fitting regions of parameter space. In the second stage (appraisal), the algorithm performs a statistical analysis of the model ensemble and computes a weighted mean model and its standard deviation. This technique, rather than simply looking at the best model, extracts the most stable features of the earthquake rupture that are consistent with the data and gives an estimate of the variability of each model parameter. We present some synthetic tests to show the effectiveness of the method and its robustness to uncertainty of the adopted crustal model. Finally, we apply this inverse technique to the well recorded 2000 western Tottori, Japan, earthquake (Mw 6.6); we confirm that the rupture process is characterized by large slip (3-4 m) at very shallow depths but, differently from previous studies, we imaged a new slip patch (2-2.5 m) located deeper, between 14 and 18 km depth. Copyright 2007 by the American Geophysical Union.

  5. Measurement of radon on Misasa district, Tottori pref. using the PICO-RAD detector and a liquid scintillation spectrometer. 3

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    Koga, Taeko; Inagaki, Masayo; Morishima, Hiroshige; Tanaka, Yuki [Kinki Univ., Higashi-Osaka, Osaka (Japan). Atomic Energy Research Inst.; Nakanishi, Akihiro; Sasaki, Noriko; Mifune, Masaaki


    By means of a radon detecting device (Packard Pico-Rad System) using absorbed active charcoal and a liquid scintillation spectrometer, studies on environmental movements of radon and its decay nuclides on Misasa district in Tottori pref. were done continuously on last year. Its minimum detection limits of radon in the air are 1.7Bq/m{sup 3} and 0.43Bq/l in the water on counting time of 200 minutes. This method is able to measure conveniently and rapidly on sampling period for 24 hours. (1) Radon concentrations in the air at Misasa environs area on October and November, 1995 were ranged 7.7-59Bq/m{sup 3} in outdoor and 13-141Bq/m{sup 3} in indoor. On the results measured on Misasa area, {sup 222}Rn concentrations on Asahi district located southward from Misasa spa district and Takeda district along Tenjin stream are high, on Kojika district located east-southward from Misasa spa district and Mitoku district are low and outdoor {sup 222}Rn concentrations on Ningyo toge neighboring are low level with ranged 12-31Bq/m{sup 3}. Indoor {sup 222}Rn concentrations at Takeda district are about 4 times higher than Kojika district showed the lowest concentration and those of Kojika district are almost similar to those of Higashi Osaka. Indoor {sup 222}Rn concentration are higher than outdoor, the mean ratio of indoor to outdoor {sup 222}Rn concentration on a few sample of Takeda and Asahi districts (upper stream) are about 2 and those on the other district are shown in low tendency ranged 1-1.3. There are a few difference among some districts. (2) {sup 222}Rn concentration variations in a dwelling at Misasa spa district were observed from May to December 1995 in the time course. They are varied in range of 53-121Bq/m{sup 3} indoor, 9-50Bq/m{sup 3} outdoor and 48-188Bq/m{sup 3} in bathroom. (3) {sup 222}Rn concentration variations in water samples at Misasa spa district are 91-161Bq/l in hot spring, 2.3-10Bq/l in river water and 14-34Bq/l in well water from May to December 1995

  6. Effect of the surface geology on strong ground motions due to the 2016 Central Tottori Earthquake, Japan (United States)

    Kagawa, Takao; Noguchi, Tatsuya; Yoshida, Shohei; Yamamoto, Shinji


    On October 21, 2016, an earthquake with Japan Meteorological Agency (JMA) magnitude 6.6 hit the central part of Tottori Prefecture, Japan. This paper demonstrates two notable effects of the surface geology on strong ground motions due to the earthquake. One is a predominant period issue observed over a large area. A seismic intensity of 6 lower on the JMA scale was registered at three sites in the disaster area. However, the peak ground acceleration ranged from 0.3 to 1.4 G at the three sites because of the varying peak periods of observed strong ground motions. The spectral properties of the observations also reflect the damage around the sites. Three-component microtremors were observed in the area; the predominant ground period distributions based on horizontal to vertical spectral ratios were provided by the authors. The peak periods of the strong motion records agree well with predominant periods estimated from microtremor observations at a rather hard site; however, the predominant periods of the microtremors are slightly shorter than those of the main shock at the other two soft sites. We checked the nonlinear effect at the sites by comparing the site responses to small events and the main shock. The peak periods of the main shock were longer than those of the weak motions at the sites. This phenomenon indicates a nonlinear site effect due to large ground motions caused by the main shock. A horizontal component of the accelerogram showed rather pulsating swings that indicate cyclic mobility behavior, especially at a site close to a pond shore; ground subsidence of 20 cm was observed around the site. The peak periods of weak motions agree well with those of the microtremor observations. This implies an important issue that the predominant periods estimated by microtremors are not sufficient to estimate the effect of surface geology for disaster mitigation. We have to estimate the predominant periods under large ground motions considering the nonlinear site

  7. Measurement of radon in air using the PICO-RAD detector and a liquid scintillation spectrometer. 2. Misasa district, Tottori pref. on sampling of 1993

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    Koga, Taeko; Inagaki, Masayo; Morishima, Hiroshige; Kawai, Hiroshi; Kondo, Sohei [Kinki Univ., Higashi-Osaka, Osaka (Japan). Atomic Energy Research Inst.; Morishita, Satoru; Kitamura, Naoya; Mifune, Masaaki


    A convenient radon detecting device for the purpose of estimating natural radiation exposure is described. The {alpha} radioactivity of its daughters originated from radon gas adsorbed in fine active carbon particles exposed to air is measured with a liquid scintillation spectrometer (Packard PICO-RAD system). Its detection limit is 1.7 Bq/m{sup 3} in air with an accuracy of about 10% on 200 minutes of counting time, and correction coefficient, the ratio of measured radon concentration to standard radon concentration (about 300 Bq/m{sup 3}) is 0.75 on the standard radon gas chamber of Power Reactor and Nuclear Fuel Development Corporation. Radon concentrations at Misasa hot springs in Tottori prefecture were measured using the PICO-RAD method on 1993. They were 128-3,600 Bq/m{sup 3} in a bath room, 25-45 Bq/m{sup 3} outdoors and 28-89 Bq/m{sup 3} indoors. (author).

  8. Locality Record of Leptobrachium smithi Matsui, Nabhitabhata & Panha, 1999 (Anura: Megophryidae on the north bank of Brahmaputra river in India

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    Dipankar Dutta


    Full Text Available The genus Leptobrachium Tschudi, 1838 is currently represented by 32 species all over the world distributed throughout mainland and insular Asia with two species so far from India. Leptobrachium smithi is known from Rani-Gharbhanga Landscape, Borduar-Mayang Landscape, Barail Range and Barak Valley all from south of River Brahmaputra. We herein report additional distribution records of Leptobrachium smithi from Ultapani Reserve Forest, Shankarghala and Mathanguri of Manas National Park on the north bank of the River Brahmaputra. The report from Ultapani, Shankarghala and Mathanguri is an extension of range of species by around 100 to 176 km north. Mineralogic and stratigraphic data of Brahmaputra basin indicates that the Brahmaputra River has changed position several times during the Holocene. The presence of the species on the north bank across the river barrier may be attributed to the positional changes of the river and due to lateral shifting of the river.

  9. Radon concentrations in the water of Misasa area (Tottori Pref.)

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    Morishima, Hiroshige; Koga, Taeko; Inagaki, Masayo [Kinki Univ., Higashi-Osaka, Osaka (Japan); Mifune, Masaaki


    UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) Report (1988, 1993) indicated that the internal exposure dose of absorption of radon (Rn-222) and the short-lived decay product nucleus occupied about half of 2.4 m Sv of the global average of annual dose of natural radiation source. It is said to be the largest factor of radiation dose of natural radiation. Sample collection and the method, the elution properties by the concentration of Rn-222 in water and the comparison of characteristics among the different methods are explained. The detection limit of concentration of radon in water by OPTI-FLUOR direct method using the liquid scintillator spectrometer was 1.5 Bq/l for 20 mins counting. The maximum radon concentrations determined by this method showed 1700 Bq/l of the spring water in Misasa area, 400 Bq/l of the small water supply system and well and 18 Bq/l of Mitoku river. (S.Y.)

  10. Cladophialophora inabaensis sp. nov., a New Species among the Dark Septate Endophytes from a Secondary Forest in Tottori, Japan. (United States)

    Usui, Erika; Takashima, Yusuke; Narisawa, Kazuhiko


    A novel species of Cladophialophora is herein described from the natural environment of secondary forest soil in Japan, which was able to be colonized by the host plant root. Morphological observations indicated that the isolate is distinct from previously identified species, and, thus, is described as the new species, C. inabaensis sp. nov.

  11. Jaapani praegune arhitektuur

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    Rotermanni soolalaos arhitektuurimuuseumi saalis näitusel "Jaapani kaasaegne arhitektuur" on esindatud Kengo Kuma, Taro Ashihara, Chiaki Arai, Tetsuo Furuichi, Nobuaki Furuya, Kazuo Iwamura, Atsushi Kitagawara, George Kunihiro, Tadasu Ohe, Hidetoshi Ohno, Ken Yokogawa

  12. Effect of Senna alata (L) Roxb (Fabaceae) Leaf Extracts on alpha ...

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    Tropical Journal of Pharmaceutical Research is indexed by Science Citation Index (SciSearch), Scopus,. International ... forest, is of great importance in traditional medical practice in ..... Atlas, 6th ed., Brussels, Belgium, 2013. 16. Matsui T ...

  13. Congenital Ocular Motor Apraxia

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    J Gordon Millichap


    Full Text Available The clinical and neuroradiological findings, and long-term intellectual prognosis in 10 patients (4 boys and 6 girls with congenital ocular motor apraxia (COMA are reviewed by researchers at Tottori University, Yonago, Japan.

  14. Clinostomum complanatum (Trematoda: Clinostomatidae) in five new fish hosts in Japan. (United States)

    Aohagi, Y; Shibahara, T; Machida, N; Yamaga, Y; Kagota, K


    Metacercariae of Clinostomum complanatum were found in six species of natural freshwater fishes collected at Koyama Pond in Tottori City of Tottori Prefecture, Japan. Five of these fish species are reported here as new records for second intermediate hosts of C. complanatum in Japan: the silver crucian carp (Carassius gibelio langsdorfi), the deepbodied crucian carp (Carassius cuvieri), the carp (Cyprinus carpio), the topmouth gudgeon (Pseudorasbora parva) and the rose bitterling (Rhodeus ocelatus).

  15. The reasons for triple therapy in stable COPD patients in Japanese clinical practice


    Miyazaki M; Nakamura H; Takahashi S; Chubachi S; Sasaki M.; Haraguchi M; Terai H; Ishii M; Fukunaga K; Tasaka S; Soejima K; Asano K.; Betsuyaku T


    Masaki Miyazaki,1 Hidetoshi Nakamura,1,2 Saeko Takahashi,1 Shotaro Chubachi,1 Mamoru Sasaki,1 Mizuha Haraguchi,1 Hideki Terai,1 Makoto Ishii,1 Koichi Fukunaga,1 Sadatomo Tasaka,1 Kenzo Soejima,1 Koichiro Asano,3 Tomoko Betsuyaku1 On behalf of the Keio COPD Comorbidity Research (K-CCR) group 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 2Department of Respiratory Medicine, Saitama Medical University, Saitama, 3Division of Pulmonary Medici...

  16. Genetic analysis of calf market weight and carcass traits in Japanese Black cattle. (United States)

    Shojo, M; Okanishi, T; Anada, K; Oyama, K; Mukai, F


    Heritabilities of and genetic correlations between additive direct and maternal genetic effects for calf market weight, and additive direct genetic effects for carcass traits, were estimated for Japanese Black cattle by REML procedures under 2-trait animal models. Data were collected from calf and carcass markets in Hyogo and Tottori prefectures and analyzed separately by prefecture. Calf market weight was measured on 42,745 and 23,566 calves in Hyogo and Tottori, respectively. Only the fattening animals with calf market weight were extracted from the carcass database and used for estimation. The carcass traits analyzed were carcass weight, ribeye area, rib thickness, subcutaneous fat thickness, yield estimate, beef marbling score, and 4 meat characters (color, brightness, firmness, and texture). Direct and maternal heritabilities for calf market weight were estimated to be 0.22 and 0.07 in Hyogo, and 0.37 and 0.15 in Tottori, respectively. The estimates of heritabilities for carcass traits were moderate to high in both prefectures. The estimates of direct-maternal genetic correlations for calf market weight were positive (0.17) in Hyogo and negative (-0.63) in Tottori. The direct effect for calf market weight was positively correlated with the direct effect for carcass weight (0.87 and 0.56 in Hyogo and Tottori, respectively) but negatively correlated with the direct effect for beef marbling score (-0.10 in both prefectures). The estimates of genetic correlations between the maternal effect for calf market weight and the direct effects for carcass traits varied from -0.13 to 0.34 in Hyogo and from -0.14 to 0.15 in Tottori. Because direct and maternal genetic effects for early growth traits can be evaluated from calf market weight data in the production system of Japanese Black cattle, this information should be incorporated into selection and mating schemes of the breed.

  17. Effect of the coastal conservation due to beach nourishment of Totori sand dune coast


    Y. Shibutani; Matsubara, Y.; Kuroiwa, M.


    Tottori Sand Dune Coast located at western part of Japan is a sandy beach with a length about 8km facing Sea of Japan. The coast has been eroded starting around 1940s and the beach nourishment project has been carried out to restore the shoreline since 2005 at Tottori Sand Dune Coast. In the project, the deposition sands at port and river mouth were transported to the erosional area and injected in the region of the offshore erosional area and the backshore area and the total volumes of the s...

  18. Neurotransmitter Mechanisms in the Nucleus Accumbens Septi and Related Regions in the Rat Brain. (United States)


    al o.. SAWA . YANAt & KiKUYAMA. 1974). Also, application of 1979: .s ’N AS. 1980h). non-toxic doses of glutamate or glutamate-analogs to the mediobasal...rieitivritr"rre. I id, mvo/tw 9’’ 83 561 23 Kobayashi. H.. Matsui, T. and Ishii , S., Functional electron microscopy of the hypothalamic me- dian

  19. Expanding Possibilities of Periodicals for Children in Asia and the Pacific. Report of the 1997 Training Course on Production of Periodicals for Children (Tokyo, October 1-15, 1997). (United States)

    Asia/Pacific Cultural Centre for UNESCO, Tokyo (Japan).

    Following the proceedings of the training course on children's periodicals held in 1997 in Tokyo, this report contains the following articles: (1) "Children's Life and Magazines" (Jiro Saito); (2) "Periodical Picture Books to Develop Reading Skills of Children" (Tadashi Matsui); (3) "How to Produce Attractive Educational…

  20. QTL Information Table: 22 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available 36 Genjah Wangkal (IRGC 35652) A R26 C424 pha Miyamoto, N., Goto, Y., Matsui, M., Ukai, Y., Morita, M., and Nemoto, K. (2004). Quanti...tative trait loci for phyllochron and tillering in rice. Theor Appl Genet 109, 700-706. ...

  1. Disease: H00967 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available mon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki... Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami

  2. Teater

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    VAT Teatri "Kalevipoeg" annab etendusi 2.-15. aug. rahvusvahelisel liikuval teatrifestivalil "Vertical Tour of Japan", mis toimub Jaapani ja Euroopa Liidu koostööaasta raames. VAT Teatri lavastust mängitakse teatrilavadel Tokios, Tottoris ja Hokkaidos ; Setumaal esietenduvast "Taarkast", Soorinna külas etenduvast "Eesti ballaadidest"

  3. Dealing with problems on sexual harassment in universities; Sekuhara mondai niokeru daigaku no torikumi

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    Michiue, Masanori. [Tottori University, Tottori (Japan)


    Authors carried out the outside evaluation that the education system, equipment from curriculum and results of faculty staff were checked by not only self-inspection and evaluation but also insight people outside the faculty in the engineering faculty in the Tottori University. As one part of this evaluation, a guideline to the sexual harassment was made. After then, a guideline to the sexual harassment in each university was completed after learned from the example of the Tottori University. This kind of regulation was made in offices of each ministry and agency, self governing body and company according to the direction of the National Personal Authority. Until recent time, the regulation related to student discussion on the sexual harassment was set up in whole the Tottori University, an environment to make students study at ease was adjusted. These items had the regulation related to student discussion, protection, guideline, when damage happened, and the student discussion room. These items were listed in the student living guideline on the homepage of the Tottori University. (NEDO)


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    Aripiprazole appears effective in its treatment. WAJM 2011; ... épileptiques réfractaires est difficile à éviter pour les médecins .... could be a good alternative to flunarazine. She started the drug in ..... Burris KD, Molski TF, Xu C Ryan E,. Tottori K ...

  5. Teater

    Index Scriptorium Estoniae


    VAT Teatri "Kalevipoeg" annab etendusi 2.-15. aug. rahvusvahelisel liikuval teatrifestivalil "Vertical Tour of Japan", mis toimub Jaapani ja Euroopa Liidu koostööaasta raames. VAT Teatri lavastust mängitakse teatrilavadel Tokios, Tottoris ja Hokkaidos ; Setumaal esietenduvast "Taarkast", Soorinna külas etenduvast "Eesti ballaadidest"

  6. Geochemical behavior of rare-earth elements and other major and minor elements in sound-producing and silent beach sands in Japan

    Institute of Scientific and Technical Information of China (English)


    The major element composition of sound-producing sand is reported together with rare-earth elements (REE) and other selected elements for the first time. Rare-earth element concentrations in beach sands from Miyagi and Tottori in Japan were determined by induction-coupled, argon-plasma spectrometry (ICP-MS) to characterize the REE of sound-producing and silent sands relative to the parental rocks. Sound-producing sand beaches are very common and all over in Japan: five beaches in Miyagi and 2 in Tottori are selected with other silent sand beaches in the areas. Both sound-producing sand and silent sand samples from Miyagi and Tottori contain more than 60wt% of SiO2 and are composed mainly of quartz and feldspar. Miyagi sand samples are characterized by light REE enrichment and flat chondrite-normalized patterns that are similar to those of local source sandstone. However, all sand samples from Miyatojima in Miyagi show positive Eu anomalies, a characteristic feature not shown in other sand samples from Miyagi. Tottori sand samples also are characterized by high REE contents and remarkable positive Eu anomalies. The sands containing lower REE contents are due to high quartz and feldspar contents. Miyatojima sand samples and Tottori sand samples have high REE contents and show remarkable positive Eu anomalies due to the presence of feldspar.The best results are obtained using all of the geological methods and the Principal Component Analysis (PCA) as a measure of the similarity between sound-producing sand and silent sand. The difference between sound-producing sand and silent sand is obtained from the PCA results.

  7. Microwave Processing of Materials (United States)


    Pennsylvania: Materials Research Society. Wagner, C., and W. Schottky. 1930. Zeitschrift fuer Physikalische Chemie. BL11:163. Walkiewicz, J. W., A. E. Clark...Science and Engineering. 66:468--469. Bloch, F. 1928. Zeitschrift fuer Physik. 52:555. Boch, P., N. Lequeux and P. Piluso. 1992. Reaction Sintering...Frankel, J. 1926. Zeitschrift fuer Physik. 35:652. Fukushima, H., T. Yamaka, and M. Matsui. 1990. Microwave Heating of Ceramics and its Application to

  8. Pulmonary intravascular large B-cell lymphoma successfully treated with rituximab, cyclophosphamide, vincristine, doxorubicin and prednisolone immunochemotherapy: Report of a patient surviving for over 1 year


    NISHII-ITO, SHIZUKA; Izumi, Hiroki; Touge, Hirokazu; TAKEDA, KENICHI; Hosoda, Yuzuru; Yamasaki, Akira; Kuwamoto, Satoshi; Shimizu, Eiji; Motokura, Toru


    A 73-year-old man with a history of lethargy, fever and dyspnea was admitted to Tottori University Hospital. A computed tomography (CT) scan revealed splenomegaly and diffusely spreading ground-glass opacities (GGOs) in both lungs. A video-assisted thoracoscopic surgery (VATS)-guided lung biopsy revealed intravascular proliferation of large atypical lymphoid cells in the arteries, veins and alveolar walls. The patient was diagnosed with intravascular large B-cell lymphoma (IVLBCL); he receive...

  9. Acknowledgments to reviewers of World Journal of Biological Chemistry

    Institute of Scientific and Technical Information of China (English)


    Many reviewers have contributed their expertise and time to the peer review, a critical process to ensure the quality of World Journal of Biological Chemistry. The editors and authors of the articles submitted to the journal are grateful to the following reviewers for evaluating the articles (including those published in this issue and those rejected for this issue) during the last editing time period. Hiroaki Itamochi, MD, PhD, Junior Associate Professor, Department of Obstetrics and Gynecology, Tottori University School of

  10. Comparison of clinical features between primary and drug-induced sleep-related eating disorder


    Komada Y; Takaesu Y; Matsui K.; Nakamura M; Nishida S; Kanno M; Usui A; Inoue Y


    Yoko Komada,1 Yoshikazu Takaesu,2 Kentaro Matsui,3 Masaki Nakamura,3 Shingo Nishida,3 Meri Kanno,3,† Akira Usui,3 Yuichi Inoue1,3 1Department of Somnology, 2Department of Psychiatry, Tokyo Medical University, 3Japan Somnology Center, Institute of Neuropsychiatry, Tokyo, Japan †Meri Kanno passed away on March 1, 2016 Purpose: The aim of this study was to ascertain the clinical characteristics of drug-induced sleep-related eating disorder (SRED). Patients and me...

  11. Effect of aging on oral and swallowing function after meal consumption

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    Hiramatsu T


    Full Text Available Tetsuya Hiramatsu,1,2 Hideyuki Kataoka,3 Mari Osaki,4 Hiroshi Hagino3,4 1Department of Speech Pathology and Audiology, Matsue Co-medical College, Matsue, Japan; 2Graduate School of Medical Sciences, Tottori University, 3School of Health Science, Faculty of Medicine, Tottori University, 4Rehabilitation Division, Tottori University Hospital, Yonago, Japan Background/purpose: Dysphagia may worsen due to fatigue of the infrahyoid and suprahyoid muscle groups as a result of repetitive swallowing during a meal. We investigated the hypothesis that meal consumption may reduce tongue strength and endurance in older adults (OAs.Methods: Tongue–palate pressure, oral diadochokinesis, repetitive saliva swallowing, and surface electromyography activity before and after a meal were measured in 23 young adults (YAs and 23 OA volunteers.Results: There was a statistically significant difference in both tongue pressure and the number of voluntary swallows between YAs and OAs. Peak tongue pressure was significantly lower in OAs than YAs both before and after meal consumption. The most notable finding was that the first time interval (the time from test initiation to the beginning of the first swallow was prolonged after meal consumption only in OAs, whereas the first time interval showed no difference between YAs and OAs before meal consumption with reference to the repetitive saliva swallowing test. The initiation of swallowing was prolonged by both meal consumption and aging; there was a significant interaction between these two factors. The number of repetitions of the monosyllable/pa/was statistically similar between YAs and OAs before meal consumption, but it was significantly lower in OAs after meal consumption.Conclusion: Aging leads to declining tongue pressure and motor function of the lips. It is possible that swallowing function declines in older individuals when meal consumption is prolonged, especially at the end of mealtime, as a result of their

  12. 古淀江潟の予察的検討


    中村, 唯史; 徳岡, 隆夫; 赤坂, 正秀


    A glassy fine volcanic ash layer and a diatomite bed were discovered to intercalate in the Holocene sediments from several boring cores in the Yodoe Plain,Tottori Prefecture.The volcanic ash layer,about 0.2cm thick,intercalates in organic mudstone.It is rich in bubble-type volcanic glasses,containing subordinate pumice-type volcanic glasses and rare phenocrysts of hyperthene and augite.The glasses are mostly brown in color.On the basis of EPMA analysis,these are safely idetified to the Akahoy...

  13. Revenue Prediction of Local Event using Mathematical Model of Hit Phenomena

    CERN Document Server

    Ishii, Akira; Miki, Shinji


    Theoretical approach to investigate human-human interaction in society performed using a many-body theory including human-human interaction. The advertisement is treated as an external force. The word of mouth (WOM) effect is included as a two-body interaction between humans. The rumor effect is included as a three-body interaction between humans. The parameters to define the strength of human interactions are assumed to be constant values. The calculated result explained well the two local events "Mizuki-Shigeru Road in Sakaiminato" and "the sculpture festival at Tottori" in Japan.

  14. Communities of arbuscular mycorrhizal fungi in the roots of Pyrus pyrifolia var. culta (Japanese pear) in orchards with variable amounts of soil-available phosphorus. (United States)

    Yoshimura, Yuko; Ido, Akifumi; Iwase, Koji; Matsumoto, Teruyuki; Yamato, Masahide


    We examined the colonization rate and communities of arbuscular mycorrhizal fungi (AMF) in the roots of Pyrus pyrifolia var. culta (Japanese pear) in orchards to investigate the effect of phosphorus (P) fertilization on AMF. Soil cores containing the roots of Japanese pear were collected from 13 orchards in Tottori Prefecture, Japan. Soil-available P in the examined orchards was 75.7 to 1,200 mg kg(-1), showing the extreme accumulation of soil P in many orchards. The AMF colonization rate was negatively correlated with soil-available P (P orchard environment.

  15. Support to Hand-Making Education in Local Communities (United States)

    Nagashima, Masaaki; Akiyama, Masahiko; Ishibuchi, Nobutaka; Nonami, Masahiro; Kawamura, Naoki; Kobayashi, Yoko; Hayakawa, Motozo

    The ICEE (Innovation Center for Engineering Education) was founded in April 2004 as an educational facility in the Faculty of Engineering of Tottori University. The ICEE plans the development and training of creative professionals in all fields of engineering through Project Based Learning Programs in collaboration with local enterprises. The ICEE also aims to enlighten children of local schools by providing manufacturing classes regularly, and we hope the ICEE to be a true center of practical engineering not only the university but also in the local society of this area. In this report, the outline and the educational effect of various support programs to hand-making education in local communities are described.

  16. Spin waves in a skyrmion crystal (United States)

    Petrova, Olga; Tchernyshyov, Oleg


    We derive the spectrum of low-frequency spin waves in skyrmion crystals observed recently in noncentrosymmetric ferromagnets [1-4]. We treat the skyrmion crystal as a superposition of three helices whose wavevectors form an equilateral triangle [1]. The low-frequency spin waves are Goldstone modes associated with displacements of skyrmions. Their dispersion is determined by the elastic properties of the skyrmion crystal and by the kinetic terms of the effective Lagrangian, which include both kinetic energy and a Berry phase term reflecting a non-trivial topology of magnetization. The Berry phase term acts like an effective magnetic field, mixing longitudinal and transverse vibrations into a gapped cyclotron mode and a twist wave with a quadratic dispersion [5]. [4pt][1] Muehlbauer, Binz, Jonietz, Pfleiderer, Rosch, Neubauer, Georgii, Boeni, Science 323, 915 (2009). [0pt][2] Muenzer, Neubauer, Adams, Muehlbauer, Franz, Jonietz, Georgii, et al., Phys. Rev. B 81, 041203 (2010). [0pt][3] Yu, Onose, Kanazawa, Park, Han, Matsui, Nagaosa, Tokura, Nature 465, 901 (2010). [0pt][4] Yu, Kanazawa, Onose, Kimoto, Zhang, Ishiwata, Matsui, Tokura, Nat. Mater. 10, 106 (2011). [0pt][5] Petrova, Tchernyshyov, arXiv:1109.4990v2 [cond-mat.mes-hall

  17. Atomistic modeling of peptide adsorption on rutile (100) in the presence of water and of contamination by low molecular weight alcohols. (United States)

    Friedrichs, Wenke; Langel, Walter


    Previous models for the interface between titanium implants and biosystems take into account the oxide passivation layer and the hydroxylation, but omit the hydrocarbon contamination on air-exposed samples. The authors develop a consistent model for the contamination of the rutile (100) surface by small alcohols, which are known to be present in ambient atmosphere, and use this approach in molecular dynamics calculations. Contact angle evaluation reveals that hydrophobic surfaces can be generated. During molecular dynamics simulations with three peptides (RPRGFGMSRERQ, WFCLLGCDAGCW, and RKLPDA), polar side chains penetrate the hydrocarbons and become immobilized on the titanium dioxide. In the carbon layer, the peptide recognizes a hydrophobic environment, which was not present on the clean surface, and the authors attribute changes in the secondary structure in one case to this interaction. The authors further include the popular Matsui-Akaogi approach [M. Matsui and M. Akaogi, Mol. Simul. 6, 239 (1991)] into the frame of the AMBER force field and quote van der Waals parameters for fitting the original Buckingham part. With the new potential, the authors evaluated lattice parameters, thermal fluctuation, and bulk modulus. Translational diffusion coefficients and dipole autocorrelation functions of water on the surface are discussed in relation to surface properties, and it is shown that the water layers are more rigid than on earlier titanium dioxide models, and that contacts between peptide and surface are less direct.

  18. Birth cohort study on the effects of desert dust exposure on children's health: protocol of an adjunct study of the Japan Environment & Children's Study. (United States)

    Kanatani, Kumiko T; Adachi, Yuichi; Sugimoto, Nobuo; Noma, Hisashi; Onishi, Kazunari; Hamazaki, Kei; Takahashi, Yoshimitsu; Ito, Isao; Egawa, Miho; Sato, Keiko; Go, Tohshin; Kurozawa, Youichi; Inadera, Hidekuni; Konishi, Ikuo; Nakayama, Takeo


    Desert dust is estimated to constitute about 35% of aerosol in the troposphere. Desertification, climatic variability and global warming all can contribute to increased dust formation. This study aims to examine possible health effects of desert dust exposure on pregnant women and their children. The purpose of this report was to present the study protocol. This 4-year birth cohort study began in 2011 as an adjunct study of the Japan Environment & Children's Study (JECS) involving three regions: Kyoto, Toyama and Tottori. The JECS participants of the three regions above who also agreed to participate in this adjunct study were enrolled prior to delivery. Light Detecting and Ranging (LIDAR) with a polarisation analyser, which can distinguish mineral dust particles from other particles, is used for exposure measurements. Outcomes are allergic symptoms for mothers and development of asthma and other allergic or respiratory diseases for their children. Data are acquired in a timely manner by connecting local LIDAR equipment to an online questionnaire system. Participants answer the online questionnaire using mobile phones or personal computers. The study protocol was approved by the ethics committees of Kyoto University, University of Toyama and Tottori University. All participants provided written informed consent. The results of this study will be published in peer-reviewed journals and disseminated to the scientific community and general public. UMIN000010826. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to

  19. Birth cohort study on the effects of desert dust exposure on children's health: protocol of an adjunct study of the Japan Environment & Children’s Study (United States)

    Kanatani, Kumiko T; Adachi, Yuichi; Sugimoto, Nobuo; Noma, Hisashi; Onishi, Kazunari; Hamazaki, Kei; Takahashi, Yoshimitsu; Ito, Isao; Egawa, Miho; Sato, Keiko; Go, Tohshin; Kurozawa, Youichi; Inadera, Hidekuni; Konishi, Ikuo; Nakayama, Takeo


    Introduction Desert dust is estimated to constitute about 35% of aerosol in the troposphere. Desertification, climatic variability and global warming all can contribute to increased dust formation. This study aims to examine possible health effects of desert dust exposure on pregnant women and their children. The purpose of this report was to present the study protocol. Methods and analysis This 4-year birth cohort study began in 2011 as an adjunct study of the Japan Environment & Children’s Study (JECS) involving three regions: Kyoto, Toyama and Tottori. The JECS participants of the three regions above who also agreed to participate in this adjunct study were enrolled prior to delivery. Light Detecting and Ranging (LIDAR) with a polarisation analyser, which can distinguish mineral dust particles from other particles, is used for exposure measurements. Outcomes are allergic symptoms for mothers and development of asthma and other allergic or respiratory diseases for their children. Data are acquired in a timely manner by connecting local LIDAR equipment to an online questionnaire system. Participants answer the online questionnaire using mobile phones or personal computers. Ethics and dissemination The study protocol was approved by the ethics committees of Kyoto University, University of Toyama and Tottori University. All participants provided written informed consent. The results of this study will be published in peer-reviewed journals and disseminated to the scientific community and general public. Trial Registration number UMIN000010826. PMID:24958210

  20. Predictors of improved functional outcome in elderly inpatients after rehabilitation: a retrospective study

    Directory of Open Access Journals (Sweden)

    Naruishi K


    Full Text Available Koji Naruishi,1,2 Akiko Kunita,3 Katsuyuki Kubo,1,2 Toshihiko Nagata,4 Shogo Takashiba,2,5 Seiji Adachi1 1Division of Local Care Center, Tottori Municipal Hospital, Tottori, Japan; 2Department of Periodontics and Endodontics, Okayama University Hospital, Okayama, Japan; 3Division of Rehabilitation, Tottori Municipal Hospital, Tottori, Japan; 4Department of Periodontology and Endodontology, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan; 5Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan Purpose: The number of elderly inpatients has been steadily increasing worldwide. However, the ability to predict the degree of improvement of functional capacity after comprehensive examination of elderly inpatients is still lacking. The purpose of this study was to investigate the predictors of improved functional outcome after rehabilitation of elderly inpatients.Methods: We performed a retrospective cohort study with 1,079 patients (age <70 years: N=331, age ≥70 years: N=748 who had been admitted to Tottori Municipal Hospital. Functional Independence Measure (FIM scores were measured both at admission and discharge to calculate FIM gain and efficiency. Of these patients, 262 patients had oral examinations on admission. The Mann–Whitney U-test or chi-square test was used for statistical analyses. Conditional logistic regression analysis was used to compute the odds ratio (OR and 95% confidence interval (CI. Cut-off values of FIM scores to determine if elderly inpatients were able to return home after discharge were determined using a receiver operating characteristic curve.Results: FIM scores, including FIM gain and efficiency, of elderly patients were significantly lower than those of middle-aged patients. Inability to close the lips and dysfunctional tongue movement, but not the loss of teeth, were correlated

  1. Cough and asthma diagnosis: physicians’ diagnosis and treatment of patients complaining of acute, subacute and chronic cough in rural areas of Japan

    Directory of Open Access Journals (Sweden)

    Akira Yamasaki


    Full Text Available Akira Yamasaki1, Keichi Hanaki2, Katsuyuki Tomita3, Masanari Watanabe1, Yasuyuki Hasagawa1, Ryota Okazaki1, Miki Yamamura1, Kouji Fukutani4, Yuji Sugimoto5, Kazuhiro Kato4, Masahiro Kodani6, Toshikazu Ikeda7, Tatsuya Konishi8, Yuji Kawasaki9, Hirokazu Tokuyasu9, Hiroki Yajima3, Hitoshi Sejima10, Takeshi Isobe11, Eiji Shimizu1, SAN-IN Asthma Research Group1Third Department of Internal Medicine, 2Department of Pediatrics, Tottori University, Japan; 3Department of Respiratory Medicine, Hakuai Hospital, Japan; 4Department of Respiratory Medicine, San-in Rosai Hospital,  Japan; 5Department of Respiratory Medicine, Tottori Prefectural Central Hospital, Japan; 6Department of Respiratory Medicine, Tottori Red Cross Hospital, Japan; 7Department of Respiratory Medicine, National Organization, Matsue Hospital, Japan; 8Department of Respiratory Medicine, Matsue City Hospital, Japan; 9Department of Respiratory Medicine, Matsue Red Cross Hospital, Japan; 10Department of Pediatrics,  11Department of Internal Medicine, Shimane University, Shimane, JapanBackground: Cough is one of the most common reasons for visiting a clinic. The causes of cough differ according to the duration of cough. Infectious disease is commonly observed in acute cough while noninfectious disease is commonly observed in chronic cough. On the other hand, cough is frequently observed in patients with asthma/cough variant asthma (CVA.Objective: In this study, we investigated the causes of cough in a rural region in Japan and the clinical examination and treatment for the patients diagnosed as asthma/CVA.Methods: We analyzed 124 patients who complained of cough.Results: The most common reason for acute cough was respiratory tract infection while asthma/CVA is the most common reason for subacute and chronic cough. The diagnostic procedure for asthma/CVA depends on clinical symptoms in asthmatic patients with acute cough. While in asthmatic patients with subacute and chronic cough, diagnosis

  2. Unified Description of Charmonium Suppression in QGP Medium

    CERN Document Server

    Singh, Captain R; Ganesh, S; Mishra, M


    Recent experimental and theoretical studies suggest that the quarkonia suppression in a thermal QCD medium created at heavy ion collisions is a complex interplay of various physical processes. In this article we put together most of these processes in a unified way to calculate the charmonium survival probability (nuclear modification factor) at energies available at relativistic heavy ion collider (RHIC) and large hadron collider (LHC) experiments. We have included shadowing as the dominant cold nuclear matter (CNM) effect. Further, gluo-dissociation and collision damping has been included which provide width to the spectral function of charmonia in a thermal medium and causes the dissociation of charmonium along with usual colour screening. We include the colour screening using our recently proposed modified Chu and Matsui model. Furthermore we incorporate the recombination of uncorrelated charm and anti-charm quark for the regeneration of charmonium over the entire temporal evolution of QGP medium. Finally...

  3. J/$\\psi$ suppression in Au+Au collisions at RHIC colour screening scenario in the bag model at variable participant numbers

    CERN Document Server

    Mishra, M; Menon, V J; Dubey, Ritesh Kumar


    We have modified the theory of Chu and Matsui by properly incorporating bag model equation of state for quark gluon plasma (QGP). We have also chosen the pressure parametrization rather than parametrizing energy density in the transverse plane. We assume that the QGP dense medium is expanding in the longitudinal direction obeying Bjorken boost invariant scaling law. Sequential melting of $\\chi_c$, $\\psi^{'}$ and $J/\\psi$ is also considered in this scenario. We have applied above formulation to the recent PHENIX experimental data of $J/\\psi$ suppression in Au+Au collisions at RHIC. We find that the model gives a good description of data at mid-rapidity in terms of survival probability versus number of participants without any necessity of implementing (3+1)-dimensional expansion of the deconfined medium.

  4. New Synthetic Method of Azuleno[1,2-c]thiophenes

    Institute of Scientific and Technical Information of China (English)

    WANG,Bing; WANG,Dao-Lin; IMAFUKU,Kimiakic


    @@ On the viewpoints of physical and chemical properties and biological activities, syntheses of a variety of heterocycle-fused azulenes have been repoted.[1] Of them, thiophene-fused azulenes were prepared by using different types of stating materials as follows. Azuleno[2,1-b] thiophenes are readily obtained from the reactions of 2-chloroazulene derivatives with ethyl mercaptoacetate in a few steps in good yield by Matsui[2] and Yamane.[3] On the other hand, the first synthesis of azuleno[1,2-c]thiophenes was accomplished by the reaction of 3-methoxycarbonyl-2H-cyclohepta[b]furan2-one with morpholino enamine of 3-oxotetrahydro-thiophene followed by dehydrogenation in poor yield by Fujimori.

  5. Retrospective study on temporal and regional variations of methylmercury concentrations in preserved umbilical cords collected from inhabitants of the Minamata area, Japan. (United States)

    Sakamoto, Mineshi; Murata, Katsuyuki; Tsuruta, Kazuhito; Miyamoto, Kenichiro; Akagi, Hirokatsu


    The present study was conducted to investigate the historical time-course changes and regional distribution of methylmercury concentrations in preserved umbilical cords collected from Minamata-area inhabitants born between 1947 and 1989. The data from Miyazaki, Tottori, Akita, Tsushima (Nagasaki), Fukuoka and Tokyo were used as controls. A total of 325 data were analyzed to estimate the temporal and spatial distribution of methylmercury among inhabitants born in the Minamata area. Elevated methylmercury concentrations (>or=1 microg/g) were mainly observed in inhabitants born between 1947 and 1968. That peak coincided with the peak of acetaldehyde production in Minamata. The methylmercury concentrations started to decrease in keeping with the decline of acetaldehyde production, which ceased in 1968, and thereafter the methylmercury levels gradually decreased to the control levels. Elevated methylmercury concentrations were first observed in the districts of Minamata, followed by Izumi, Tsunagi and Ashikita, indicating the time-course-dependent regional distributions of methylmercury pollution.

  6. Pulmonary intravascular large B-cell lymphoma successfully treated with rituximab, cyclophosphamide, vincristine, doxorubicin and prednisolone immunochemotherapy: Report of a patient surviving for over 1 year. (United States)

    Nishii-Ito, Shizuka; Izumi, Hiroki; Touge, Hirokazu; Takeda, Kenichi; Hosoda, Yuzuru; Yamasaki, Akira; Kuwamoto, Satoshi; Shimizu, Eiji; Motokura, Toru


    A 73-year-old man with a history of lethargy, fever and dyspnea was admitted to Tottori University Hospital. A computed tomography (CT) scan revealed splenomegaly and diffusely spreading ground-glass opacities (GGOs) in both lungs. A video-assisted thoracoscopic surgery (VATS)-guided lung biopsy revealed intravascular proliferation of large atypical lymphoid cells in the arteries, veins and alveolar walls. The patient was diagnosed with intravascular large B-cell lymphoma (IVLBCL); he received 6 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) immunochemotherapy and has remained in complete remission for >1 year. Although IVLBCL is a rare disease, it should be considered in the differential diagnosis of pulmonary diffuse lesions that present with GGOs on CT scans.

  7. Radon measurement using a liquid scintillation spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Koga, Taeko; Morishima, Hiroshige; Kawai, Hiroshi; Kondo, Sohei (Kinki Univ., Higashi-Osaka, Osaka (Japan). Atomic Energy Research Inst.); Mifune, Masaki; Konishi, Masanobu; Shirai, Chiaki


    A convenient radon detecting device for the purpose of estimating natural radiation exposure is described. The [alpha] radioactivity of radon gas absorbed in fine active carbon particles exposed to air is measured with a liquid scintillation spectrometer (Packard-PICO-RAD system). Its detection limits are 2mBq/l in air and 0.5 Bq/l in water with an accuracy of about 10 %. Radon concentrations at Misasa hot springs in Tottori prefecture were measured using this method. They were 0.16 [approx] 7.7 Bq/l in a bath room and 0.057 [approx] 0.36 Bq/l outdoors. Radon concentrations of the hot springs were 82 [approx] 1,700 Bq/l. (author).

  8. Rupture Process of the 2003 Bam, Iran, Earthquake: Did Shallow Asperities on a Fresh Fault Cause Extreme Ground Motions? (United States)

    Miyake, H.; Koketsu, K.; Mostafaei, H.


    The Bam, Iran, earthquake on December 26, 2003 caused heavy damage to the city of Bam including the historic heritage of Arg-e-Bam. This Mw6.5 earthquake rupture created fresh faults 5 km westward away from the Bam fault. The Bam strong-motion station recorded 992 gal in the UD component and two directivity pulses in the horizontal components with a dominant frequency of 1 Hz. We inferred the rupture process of the 2003 Bam earthquake from strong motion data observed by BHRC, together with teleseismic data to constrain global features of the source. Waveform inversions using teleseismic data (e.g. Yamanaka, 2003; Yagi, 2003) have suggested the existence of a shallow asperity. Nakamura et al. (2004) estimated aftershock distribution with vertical dipping that superimposed the fresh faults, not the Bam fault. They proposed fault planes consisting N-S alignment with northward branches beneath the city of Bam. Our preliminary analyses show that two directivity pulses are created by northward rupture near the hypocenter and north-eastward rupture beneath the city. Recent earthquakes occurred on immature faults with shallow asperities have also generated localized extreme-strong motions (e.g., 2003 Miyagi-ken Hokubu, Japan, with Mw6.1; 2000 Tottori, Japan, with Mw6.6). Larger fracture energy is expected for shallow asperities on immature faults than those on mature faults. For example, the 2000 Tottori earthquake has several times larger fracture energy than expected by the scaling between seismic moment and fracture energy. When considering the energy budget, are radiated energy from the immature faults enough to generate the extreme ground motions? Detailed source process inversions might be able to answer this question.

  9. The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents

    Directory of Open Access Journals (Sweden)

    Hiroko Sonoyama


    Full Text Available Hiroko Sonoyama1, Kaoru Araki-Sasaki1, Shigeyasu Kazama1, Tsutomu Kawasaki1, Hidenao Ideta1, Atsuko Sunada2, Seishi Asari2, Yoshitsugu Inoue3, Kozaburo Hayashi41Ideta Eye Hospital, Kumamoto, Kumamoto, Japan; 2Department of Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka, Japan; 3Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organ, Tottori University, Yonago, Tottori, Japan; 4Immunology and Virology Section Lab, Immunology, NEI, NIH, Bethesda, MD, USAAbstract: Clinical findings and treatment of keratomycosis caused by Beauveria bassiana, an entomopathogenic filamentous fungus, are described for an 80-year-old woman, who was referred to the hospital for ocular pain and redness on the 9th day after an ocular injury caused by the frame of her glasses. She had a long history of recurrent diabetic iritis and continuously used topical antibiotics and corticosteroids. At her first visit, a slit-lamp examination indicated a corneal ulcer confined within the superficial stromal layer, along with a slight infiltration and edema. Only a very few inflammatory cells were seen in the anterior chamber. Direct microscopic examination of corneal scrapings revealed septate fungal hyphae with zig-zag rachis and budding that was subsequently identified as B. bassiana by slide culture. Topical voriconazole with miconazole, pimaricin and oral itraconazole were effective and the lesion disappeared leaving only a mild scar at 2 months. The sensitivity of B. bassiana to various antimycotic agents was confirmed by broth microdilution, agar dilution with the Clinical Laboratory Standard Institute standard, and a disk method using topically applied concentrations. B. bassiana, which exhibits a characteristic appearance in smears and causes superficial keratomycosis, is sensitive to voriconazole with miconazole, pimaricin, and itraconazole.Keywords: Beauveria bassiana, keratomycosis, filamentous

  10. Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate copolymer

    Directory of Open Access Journals (Sweden)

    Lee KD


    Full Text Available Kyung Dong Lee,1,* Young-Il Jeong,2,* Da Hye Kim,3,4 Gyun-Taek Lim,2 Ki-Choon Choi5 1Department of Oriental Medicine Materials, Dongshin University, Naju, South Korea; 2Department of Polymer Engineering, Chonnam National University, Gwangju, South Korea; 3Faculty of Life and Environmental Science, Shimane University, Matsue, Japan; 4United Graduate School of Agricultural Sciences, Tottori University, Tottori, Japan; 5Grassland and Forages Division, National Institute of Animal Science, Rural Development Administration, Cheonan, South Korea *These authors contributed equally to this work Background: Although cisplatin is extensively used in the clinical field, its intrinsic toxicity limits its clinical use. We investigated nanoparticle formations of poly(acrylic acid-co-methyl methacrylate (PAA-MMA incorporating cisplatin and their antitumor activity in vitro and in vivo. Methods: Cisplatin-incorporated nanoparticles were prepared through the ion-complex formation between acrylic acid and cisplatin. The anticancer activity of cisplatin-incorporated nanoparticles was assessed with CT26 colorectal carcinoma cells. Results: Cisplatin-incorporated nanoparticles have small particle sizes of less than 200 nm with spherical shapes. Drug content was increased according to the increase of the feeding amount of cisplatin and acrylic acid content in the copolymer. The higher acrylic acid content in the copolymer induced increase of particle size and decrease of zeta potential. Cisplatin-incorporated nanoparticles showed a similar growth-inhibitory effect against CT26 tumor cells in vitro. However, cisplatin-incorporated nanoparticles showed improved antitumor activity against an animal tumor xenograft model. Conclusion: We suggest that PAA-MMA nanoparticles incorporating cisplatin are promising carriers for an antitumor drug-delivery system. Keywords: cisplatin, nanoparticle, poly(acrylic acid-co-methyl methacrylate, ion complexes

  11. Pioglitazone improves the cardio-ankle vascular index in patients with type 2 diabetes mellitus treated with metformin

    Directory of Open Access Journals (Sweden)

    Ohira M


    Full Text Available Masahiro Ohira,1 Takashi Yamaguchi,1 Atsuhito Saiki,1 Noriko Ban,1 Hidetoshi Kawana,1 Ayako Nagumo,1 Takeyoshi Murano,2 Kohji Shirai,3 Ichiro Tatsuno1 1Center for Diabetes, Endocrinology and Metabolism, 2Department of Clinical Laboratory Medicine, 3Department of Vascular Function, Sakura Hospital, Toho University Medical Center, Chiba, Japan Background: Type 2 diabetes is known to be associated with elevated cardiovascular mortality. Pioglitazone improves blood pressure (BP and pulse wave velocity (PWV, which is an arterial stiffness parameter. Arterial stiffness is closely associated with cardiovascular disease. However, PWV is correlated with BP. The cardio-ankle vascular index (CAVI reflects arterial stiffness independent of BP. Pioglitazone improves PWV but reduces blood pressure. The aim of this study was to re-evaluate the effect of pioglitazone on arterial stiffness with CAVI. Methods: Sixty patients with type 2 diabetes mellitus and already on 500 mg/day of metformin received add-on therapy of pioglitazone 15 mg/day or glimepiride 1 mg/day for 6 months, during which time changes in their metabolic parameters and CAVI were observed. Results: After 6 months of treatment, both pioglitazone (n=30 and glimepiride (n=30 improved fasting blood glucose and glycated hemoglobin. The changes in fasting blood glucose and glycated hemoglobin between the two groups were greater in the pioglitazone group. Systolic and diastolic BP was decreased in both groups, with no significant between-group differences. Only pioglitazone increased serum adiponectin levels, and the change in adiponectin between the pioglitazone and glimepiride groups was significantly different. CAVI was decreased significantly by pioglitazone but remained unchanged after treatment with glimepiride. The change in CAVI between the two groups was significantly different. Conclusion: These results suggest that pioglitazone improves CAVI, a BP-independent arterial stiffness parameter

  12. Optical Lattice Clocks (United States)

    Oates, Chris


    Since they were first proposed in 2003 [1], optical lattice clocks have become one of the leading technologies for the next generation of atomic clocks, which will be used for advanced timing applications and in tests of fundamental physics [2]. These clocks are based on stabilized lasers whose frequency is ultimately referenced to an ultra-narrow neutral atom transition (natural linewidths magic'' value so as to yield a vanishing net AC Stark shift for the clock transition. As a result lattice clocks have demonstrated the capability of generating high stability clock signals with small absolute uncertainties (˜ 1 part in 10^16). In this presentation I will first give an overview of the field, which now includes three different atomic species. I will then use experiments with Yb performed in our laboratory to illustrate the key features of a lattice clock. Our research has included the development of state-of-the-art optical cavities enabling ultra-high-resolution optical spectroscopy (1 Hz linewidth). Together with the large atom number in the optical lattice, we are able to achieve very low clock instability (< 0.3 Hz in 1 s) [3]. Furthermore, I will show results from some of our recent investigations of key shifts for the Yb lattice clock, including high precision measurements of ultracold atom-atom interactions in the lattice and the dc Stark effect for the Yb clock transition (necessary for the evaluation of blackbody radiation shifts). [4pt] [1] H. Katori, M. Takamoto, V. G. Pal'chikov, and V. D. Ovsiannikov, Phys. Rev. Lett. 91, 173005 (2003). [0pt] [2] Andrei Derevianko and Hidetoshi Katori, Rev. Mod. Phys. 83, 331 (2011). [0pt] [3] Y. Y. Jiang, A. D. Ludlow, N. D. Lemke, R. W. Fox, J. A. Sherman, L.-S. Ma, and C. W. Oates, Nature Photonics 5, 158 (2011).

  13. The runaway Greenhouse revisited: it's "theoretically possible for an Earth-like planet at 1 AU", plus implications for more diverse planets (United States)

    Goldblatt, C.; Zahnle, K. J.; Crisp, D.; Robinson, T. D.


    For water-vapour rich atmospheres, there is an asymptotic limit on thermal emission to space. If more sunlight is absorbed than this limit, energy balance is no longer possible and runaway heating occurs, evaporating the ocean and sterilizing the planet en route. Here, we present recently published work (Goldblatt et al., 2013) which was the first full re-evaluation of the problem since classic 1980's era work (e.g. Watson et al., 1984; Abe & Matsui, 1988; Kasting, 1988). With modern molecular absorption databases and a line-by-line resolution model, we find that the thermal limit is lower than previous estimates (282Wm-2, down from 310Wm-2) and that much more sunlight is absorbed by a steam atmosphere (294Wm-2, up from 222Wm-2). The immediate implication is that a cloud-free moist atmosphere on Earth would cause a runaway greenhouse. Triggering it would simply be a matter of sufficient heating, with around 30,000ppmv being sufficient in our most Earth-like model. This is substantially different than previous calculations, where weak solar absorption meant that a higher solar flux was required. Our published calculations are for the limit of clear-skies; any clouds would reduce both the thermal radiation emitted and the solar radiation absorbed, so clouds could make the runaway greenhouse either more or less likely. It can be shown that and excess of cloud reflection over cloud greenhouse is required to maintain temperate climate on Earth today - but how clouds will change in a warming atmosphere is far from clear. Work in progress (and hopefully ready by December!) on cloudy runaway greenhouse models will hopefully constrain this better. Wider implications for planetary stability will also be discussed. For example, water-world planets, with minimal background gas in the atmosphere may be highly susceptible to runaway greenhouses (heating Europa might take it directly from a snowball to a runaway). High CO2 levels after previous Snowball Earth events did not

  14. Living-fossil coccolithophore survivors of the Cretaceous-Paleogene mass extinction (United States)

    Hagino, K.; Young, J. R.; Bown, P. R.; Godrijan, J.; Kogame, K.; Kulhanek, D. K.; Horiguchi, T.


    Calcareous nannofossils (coccolithophores and other associated fossils), diversified greatly through the middle-late Mesozoic, but around 90% of these species became extinct at the K/Pg event. Although the specific cause of this mass extinction is still uncertain, the record of extinction and survivorship of nannoplankton has informed our understanding of the rates of extinction and recovery, and nature of survivorship in the plankton ecosystem. Recently we found living cells of a coccolithophore, which morphologically and structurally resembles the Mesozoic genus Cyclagelosphaera, from coastal-neritic waters of Tottori, Japan and of Rovinj, Croatia. Cyclagelosphaera is a characteristic Mesozoic genus that appeared in the middle Jurassic. It survived the K/Pg event, briefly flourished in post K/Pg oceans, with other K/Pg survivors, but disappeared from the fossil record in the Eocene. Bibliographic study has revealed that our specimens correspond to a living species Tergestiella adriatica, which was discovered from offshore Rovinji in 1934 but has never since been reported. Molecular phylogenetic studies of T. adriatica based on SSU rDNA sequences show that T. adriatica branched from the base of the clade of other living coccolithophores. This result suggests that T. adriatica diverged from the ancestor of other coccolithophores before the diversification of other taxa and supports the inference that T. adriatica is a direct descendent of Mesozoic Cyclagelosphaera rather than a homoeomorph. Floristic studies of living coccolithophores show that T. adriatica coexists with Braarudosphaera bigelowii, another K/Pg survivor, in the coastal area of Tottori, Japan. In both Mesozoic and Cenozoic oceans, calcareous nannoplankton are typically open-ocean dwellers, but a few taxa are confined to coastal waters. Curiously, all three extant coccolithophores with Mesozoic fossil records are coastal, meanwhile the other extant taxa with Cenozoic fossil records are oceanic. Our

  15. Ophthalmic viscosurgical device backflow into cartridge during intraocular lens insertion using injectors

    Directory of Open Access Journals (Sweden)

    Matsuura K


    Full Text Available Kazuki Matsuura,1 Yoshitsugu Inoue2 1Nojima Hospital, 2Tottori University, Kurayoshi City, Tottori, Japan Background: The purpose of this study was to assess the risk of intraocular contamination caused by intraocular lens (IOL insertion with injectors by observing the dynamics of an ophthalmic viscosurgical device (OVD. Methods: Each type of injector was equipped with a colored OVD and IOL, and a 2 mm length from the tip of the cartridge was replaced with a colored OVD. The various combinations of IOLs and injectors used were: a three-piece shaped IOL, VA60BBR + TypeE1 (HOYA incision size 2.5 mm; group A, n=5; a single-piece IOL, 251+ iSert micro, preloaded (HOYA, incision size 2.2 mm; group G, n=5; and a single-piece IOL, SN6CWS preloaded (Alcon, incision size 2.7 mm; group C, n=5. Results: In group A, the intraocular OVD instantly flowed backward into the injector, whereas the colored OVD was pushed backward deep inside the cartridge without flowing into the eye. In group B, the backflow of the intraocular OVD into the injector was limited, resulting in the influx of a large amount of the colored OVD into the eye along with the IOL. In group C, as in group A, a large amount of the intraocular OVD flowed backward into the injector. Consequently, a small amount of the colored OVD flowed into the eye. Conclusion: The tip of the injector and OVD could be contaminated because the surgical field cannot be completely sterile, even after preoperative disinfection. Our experiments revealed that OVD backflow into the injector cavity occurs during IOL insertion, and this phenomenon may have minimized intraocular contamination. However, small-diameter cartridges along with plate-type haptics allow insufficient OVD backflow, resulting in intraocular influx of the contaminated OVD. Surgeons have to be notified that intraoperative bacterial contamination can occur even after IOL insertion using injectors. Keywords: intraocular lens insertion

  16. Lipopolysaccharide-induced multinuclear cells: Increased internalization of polystyrene beads and possible signals for cell fusion

    Energy Technology Data Exchange (ETDEWEB)

    Nakanishi-Matsui, Mayumi, E-mail:; Yano, Shio; Futai, Masamitsu


    Highlights: •LPS induces multinuclear cells from murine macrophage-derived RAW264.7 cells. •Large beads are internalized by cells actively fusing to become multinuclear. •The multinuclear cell formation is inhibited by anti-inflammatory cytokine, IL10. •Signal transduction for cell fusion is different from that for inflammation. -- Abstract: A murine macrophage-derived line, RAW264.7, becomes multinuclear on stimulation with lipopolysaccharide (LPS), an outer membrane component of Gram-negative bacteria. These multinuclear cells internalized more polystyrene beads than mononuclear cells or osteoclasts (Nakanishi-Matsui, M., Yano, S., Matsumoto, N., and Futai, M., 2012). In this study, we analyzed the time courses of cell fusion in the presence of large beads. They were internalized into cells actively fusing to become multinuclear. However, the multinuclear cells once formed showed only low phagocytosis activity. These results suggest that formation of the multinuclear cells and bead internalization took place simultaneously. The formation of multinuclear cells was blocked by inhibitors for phosphoinositide 3-kinase, phospholipase C, calcineurin, and c-Jun N-terminal kinase. In addition, interleukin 6 and 10 also exhibited inhibitory effects. These signaling molecules and cytokines may play a crucial role in the LPS-induced multinuclear cell formation.

  17. Unified description of charmonium suppression in a quark-gluon plasma medium at RHIC and LHC energies (United States)

    Singh, R., Captain; Srivastava, P. K.; Ganesh, S.; Mishra, M.


    Recent experimental and theoretical studies suggest that the quarkonium suppression in a thermal QCD medium created in heavy ion collisions is a complex interplay of various physical processes. In this article we put together most of these processes in a unified way to calculate the charmonium survival probability (nuclear modification factor) at energies available at Relativistic Heavy Ion Collider (RHIC) and Large Hadron Collider (LHC) experiments. We include shadowing as the dominant cold-nuclear-matter effect. Further, gluonic dissociation and collision damping are included, which provide width to the spectral function of charmonia in a thermal medium and cause the dissociation of charmonium along with the usual color screening. We include color screening by using our recently proposed modified Chu-Matsui model. Furthermore, we incorporate the recombination of uncorrelated charm and anticharm quarks for the regeneration of charmonium over the entire temporal evolution of the QGP medium. Finally, we do a feed-down correction from the excited states to calculate the survival probability of charmonium. We find that our unified model suitably and simultaneously describes the experimental nuclear modification data of J /ψ at RHIC and LHC.

  18. Simple and Flexible Self-Reproducing Structures in Asynchronous Cellular Automata and Their Dynamics (United States)

    Huang, Xin; Lee, Jia; Yang, Rui-Long; Zhu, Qing-Sheng


    Self-reproduction on asynchronous cellular automata (ACAs) has attracted wide attention due to the evident artifacts induced by synchronous updating. Asynchronous updating, which allows cells to undergo transitions independently at random times, might be more compatible with the natural processes occurring at micro-scale, but the dark side of the coin is the increment in the complexity of an ACA in order to accomplish stable self-reproduction. This paper proposes a novel model of self-timed cellular automata (STCAs), a special type of ACAs, where unsheathed loops are able to duplicate themselves reliably in parallel. The removal of sheath cannot only allow various loops with more flexible and compact structures to replicate themselves, but also reduce the number of cell states of the STCA as compared to the previous model adopting sheathed loops [Y. Takada, T. Isokawa, F. Peper and N. Matsui, Physica D227, 26 (2007)]. The lack of sheath, on the other hand, often tends to cause much more complicated interactions among loops, when all of them struggle independently to stretch out their constructing arms at the same time. In particular, such intense collisions may even cause the emergence of a mess of twisted constructing arms in the cellular space. By using a simple and natural method, our self-reproducing loops (SRLs) are able to retract their arms successively, thereby disentangling from the mess successfully.

  19. A Comparative Study on the Therapeutic Effect of Astragaloside (

    Institute of Scientific and Technical Information of China (English)

    CHEN; Xiang-jian


    [1]Anandasabapathy S, Frishman W.H. Innovative drug treatments for viral and autoimmune myocarditis. J Clin Pharmacol 1998;38∶295-308.[2]ZHANG JN, YANG GP, SU EB, et al. The study of serum cardiac troponin I in diagnosing acute myocardial infarction. J of Chin Cardiovas Disea 1997;25(5)∶379-382.[3]ZHU BH, ZHANG JN, LIU NF, et al. The experimental study of relationship between left ventricular hypertrophy in hypertension and cardiac sarcoplasmic calcium-regulated protein. J of Chin Med 1999;79(4)∶286-288.[4]ZHANG JN, SU EB, WEI J, et al. Elevation of cardiac troponin I and its association with diagnosis and progress of viral myocarditis. Clin J Cardiol 1999;27(6)∶1-4.[5]Arai M, Matsui H, Periasamy M. Sarcoplasmic Reticulum Gene Expression in Cardiac Hypertrophy and Heart Failure. Circ Res 1994;74∶555-564.[6]LU S, ZHANG JN. The study on progress of cardiovascular pharmacological effects of Astragalus. Chin Herbs 1998;29(1)∶59-61.

  20. Evolution of erythrocyte morphology in amphibians (Amphibia: Anura

    Directory of Open Access Journals (Sweden)

    Jie Wei


    Full Text Available ABSTRACT We compared the morphology of the erythrocytes of five anurans, two toad species - Bufo gargarizans (Cantor, 1842 and Duttaphrynus melanostictus (Schneider, 1799 and three frog species - Fejervarya limnocharis (Gravenhorst, 1829, Microhyla ornata (Duméril & Bibron, 1841, and Rana zhenhaiensis (Ye, Fei & Matsui, 1995. We then reconstructed the ancestral state of erythrocyte size (ES and nuclear size (NS in amphibians based on a molecular tree. Nine morphological traits of erythrocytes were all significantly different among the five species. The results of principal component analysis showed that the first component (49.1% of variance explained had a high positive loading for erythrocyte length, nuclear length, NS and ratio of erythrocyte length/erythrocyte width; the second axis (28.5% of variance explained mainly represented erythrocyte width and ES. Phylogenetic generalized least squares analysis showed that the relationship between NS and ES was not affected by phylogenetic relationships although there was a significant linear relationship between these two variables. These results suggested that (1 the nine morphological traits of erythrocytes in the five anuran species were species-specific; (2 in amphibians, larger erythrocytes generally had larger nuclei.

  1. Diurnal Variation of Precipitation During MC3E Campaign (United States)

    Tao, Wei-Kuo; Wu, Di; Matsui, Toshi; Peters-Lidard, Christa; Hou, Arthur; Rienecker, Michele


    The diurnal variation of precipitation processes in the United States (US) is well recognized but incompletely understood (Cabone et al. 2002). The diurnal cycle of precipitation has been studied using surface rainfall data, radar reflectivity data, and satellite-derived cloudiness and precipitation (Wallace 1975; Dai et al. 1999; Carbone et al. 2002; Carbone and Tuttle, 2008; Parker and Ahijevych, 2007; Matsui et al. 2010 and others). These observations indicate that the summer-time precipitation most of the North America and typically feature late-afternoon precipitation maxima. These diurnal variation of precipitation can also be generally categorized into three different types: 1) afternoon rainfall maxima due to mesoscale and local circulations over the south and east of the Mississippi and Ohio valleys, 2) nocturnal rainfall maxima from eastward-propagating mesoscale convective systems (MCSs) over the Lee side of Rocky Mountain regions and 3) afternoon rainfall maxima in the Appalachian Mountains, and then propagate eastward toward the coast. The main objective of this paper is to use a regional cloud-scale model with very high-resolution (i.e., WRF) to examine the WRF ability to simulate diurnal variation of precipitation. Specifically, the study will (1) identify the physical processes responsible to diurnal variation of precipitation, (2) examine the sensitivity of resolution (2, 6, 18, and 30 km) to model simulated diurnal variation of precipitation and (3) identify the relationships between microphysics and cumulus parameterization schemes.

  2. Specifications of ZnO growth for heterostructure solar cell and PC1D based simulations

    Directory of Open Access Journals (Sweden)

    Babar Hussain


    Full Text Available This data article is related to our recently published article (Hussain et al., in press [1] where we have proposed a new solar cell model based on n-ZnO as front layer and p-Si as rear region. The ZnO layer will act as an active n-layer as well as antireflection (AR coating saving considerable processing cost. There are several reports presenting use of ZnO as window/antireflection coating in solar cells (Mansoor et al., 2015; Haq et al., 2014; Hussain et al., 2014; Matsui et al., 2014; Ding et al., 2014 [2–6] but, here, we provide data specifically related to simultaneous use of ZnO as n-layer and AR coating. Apart from the information we already published, we provide additional data related to growth of ZnO (with and without Ga incorporation layers using MOCVD. The data related to PC1D based simulation of internal and external quantum efficiencies with and without antireflection effects of ZnO as well as the effects of doping level in p-Si on current–voltage characteristics have been provided.

  3. High plasma concentration of beta-D-glucan after administration of sizofiran for cervical cancer

    Directory of Open Access Journals (Sweden)

    Hirokazu Tokuyasu


    Full Text Available Hirokazu Tokuyasu1, Kenichi Takeda1, Yuji Kawasaki1, Yasuto Sakaguchi2, Noritaka Isowa2, Eiji Shimizu3, Yasuto Ueda31Divisions of Respiratory Medicine, 2Thoracic Surgery, Matsue Red Cross Hospital, 200 Horomachi, Matsue, Shimane; 3Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, JapanAbstract: A 69-year-old woman with a history of cervical cancer was admitted to our hospital for further investigation of abnormal shadows on her chest roentgenogram. Histologic examination of transbronchial lung biopsy specimens revealed epithelioid cell granuloma, and Mycobacterium intracellulare was detected in the bronchial lavage fluid. The plasma level of (1→3-beta-D-glucan was very high, and this elevated level was attributed to administration of sizofiran for treatment of cervical cancer 18 years previously. Therefore, in patients with cervical cancer, it is important to confirm whether or not sizofiran has been administered before measuring (1→3-beta-D-glucan levels.Keywords: (1→3-beta-D-glucan, cervical cancer, Mycobacterium intracellulare, sizofiran

  4. COPD is frequent in conditions of comorbidity in patients treated with various diseases in a university hospital

    Directory of Open Access Journals (Sweden)

    Akira Yamasaki


    Full Text Available Akira Yamasaki, Kiyoshi Hashimoto, Yasuyuki Hasegawa, Ryota Okazaki, Miki Yamamura, Tomoya Harada, Shizuka Ito, Soichiro Ishikawa, Hiroki Takami, Masanari Watanabe, Tadashi Igishi, Yuji Kawasaki, Eiji ShimizuDivision of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, JapanBackground: Chronic obstructive pulmonary disease (COPD is one of the leading causes of death and loss of disability-adjusted life-years. However, many COPD patients are not diagnosed because of underrecognition or underdiagnosis of this disease among many patients and physicians. One possible reason is underrecognition of spirometry. In this study, we examined the prevalence of airflow limitation and underlying disease in patients with airflow limitation.Methodology: From April 2006 to March 2008, patients who had spirometry performed were examined. The original disease of patients, pulmonary function tests, smoking status, and respiratory symptoms were surveyed from their medical records.Results: Of all patients who had spirometry performed, 15.8% showed airflow limitation (FEV1/FVC < 0.7. A variety of diseases were observed in patients with airflow limitation. Among all diseases, cardiovascular disease was the highest and gastrointestinal malignant disease had the second highest prevalence in patients with airflow limitation.Conclusion: COPD might be frequent in conditions of comorbidity in patients treated for various diseases. Attention should be paid to the possibility of co-existence of COPD and the influence of COPD on these patients.Keywords: airflow limitation, chronic obstructive pulmonary disease, comorbidity, spirometry, prevalence

  5. Female sex pheromones of two Japanese saturniid species, Rhodinia fugax and Loepa sakaei: identification, synthesis, and field evaluation. (United States)

    Yan, Qi; Kanegae, Akiko; Miyachi, Takashi; Naka, Hideshi; Tatsuta, Haruki; Ando, Tetsu


    While 11 species in the family Saturniidae are found in Japan, no sex pheromones of the native species had been investigated previously. We collected larvae of Rhodinia fugax in Nagano and Tottori Prefecture, and of Loepa sakaei in Okinawa Prefecture, and extracted sex pheromones of these two species from virgin female moths. In gas chromatography-electroantennogram detection (GC-EAD) analyses, male antennae of each species responded to one component in the respective pheromone extracts of conspecific females. Chemical analyses of the extracts by GC/mass spectrometry revealed that the EAD-active compounds of R. fugax and L. sakaei were a hexadecadienal and a tetradecadienyl acetate, respectively. The two species belong to the subfamily Saturniinae, and the mass spectra of both were similar to that of the 6,11-hexadecadienyl acetate identified from Antheraea polyphemus, classified in the same subfamily, suggesting the same 6,11-dienyl structure for the C16 aldehyde and a 4,9-dienyl structure for the C14 acetate. Based on this assumption, four geometrical isomers of each dienyl compound were stereoselectively synthesized via acetylene intermediates, compared to the natural products, and tested in the field. Male catches confirmed the pheromone structures of the two Japanese saturniid species as (6E,11Z)-6,11-hexadecadienal for R. fugax and (4E,9Z)-4,9-tetradecadienyl acetate for L. sakaei. The compounds have a characteristic 1,6-dienyl motif common to the pheromones of Saturniinae species.

  6. Investigation of Finite Sources through Time Reversal (United States)

    Kremers, Simon; Brietzke, Gilbert; Igel, Heiner; Larmat, Carene; Fichtner, Andreas; Johnson, Paul A.; Huang, Lianjie


    Under certain conditions time reversal is a promising method to determine earthquake source characteristics without any a-priori information (except the earth model and the data). It consists of injecting flipped-in-time records from seismic stations within the model to create an approximate reverse movie of wave propagation from which the location of the hypocenter and other information might be inferred. In this study, the backward propagation is performed numerically using a parallel cartesian spectral element code. Initial tests using point source moment tensors serve as control for the adaptability of the used wave propagation algorithm. After that we investigated the potential of time reversal to recover finite source characteristics (e.g., size of ruptured area, rupture velocity etc.). We used synthetic data from the SPICE kinematic source inversion blind test initiated to investigate the performance of current kinematic source inversion approaches ( The synthetic data set attempts to reproduce the 2000 Tottori earthquake with 33 records close to the fault. We discuss the influence of various assumptions made on the source (e.g., origin time, hypocenter, fault location, etc.), adjoint source weighting (e.g., correct for epicentral distance) and structure (uncertainty in the velocity model) on the results of the time reversal process. We give an overview about the quality of focussing of the different wavefield properties (i.e., displacements, strains, rotations, energies). Additionally, the potential to recover source properties of multiple point sources at the same time is discussed.

  7. Comparison of {gamma}-ray profile across active normal and reverse faults; Seidansogata to gyakudansogata katsudanso ni okeru hoshano tansa kekka no hikaku

    Energy Technology Data Exchange (ETDEWEB)

    Iwata, A.; Wada, N.; Sumi, H. [Shimada Technical Consultants, Ltd., Shimane (Japan); Yamauchi, S.; Iga, T. [Shimane Univ., Shimane (Japan)


    Active faults confirmed at trench and outcrop were surveyed by the {gamma}-ray spectrometry. The active fault found at trench is a normal fault, and that found at outcrop is a reverse fault. The {gamma}-ray spectral characteristics of these two types of faults were compared to each other. The normal fault is named as Asagane fault located in Aimi-machi, Saihaku-gun, Tottori prefecture. The reverse fault is named as Yokota reverse fault located in Yokota-cho, Nita-gun, Shimane prefecture. Rises of radon gas indicating the existence of opening cracks were confirmed above the fault for the normal fault, and at the side of thrust block for the reverse fault. It was considered that such characteristics were caused by the difference of fault formation in the tensile stress field and in the compressive stress field. It was also reconfirmed that much more information as to faults can be obtained by the combined exploration method using the total counting method and the spectral method. 14 refs., 7 figs.

  8. Plumbing systems to cope with the global environmental age; Chikyu kankyo jidai ni mukete no kyuhaisui eisei system

    Energy Technology Data Exchange (ETDEWEB)

    Ogawa, M.


    Tasks to be fulfilled in relation to the plumbing system for reduction in environmental loads are discussed. They are the effective use of water (saving), extension of equipment life, and the adoption of materials imposing less load on the environment (ecomaterial). In the case of a hot-spring hotel M of Tottori Prefecture, water saving efforts are exerted by guiding the hot-spring water through a radiation coil placed in a fall-provided pond for temperature reduction. In the case of a hot-spring hotel S of Iwate Prefecture, for the effective utilization of hot-spring water gushing out in abundance, a heat exchanger is installed for exchanging heat between the hot spring water and city water. The thus-warmed city water is fed to room baths and to taps in the public bath, and the hot water overflowing the public bath is utilized as the heat source for a wastewater heat recovery heat pump before being discharged into the river. As for equipment life extension, there is for instance the case of vinyl chloride pipe which has been in use for the purpose of cost reduction. Since it is expected that the life of plastic pipes will be more than 10-20 years longer than that of metal pipes, it has become necessary to consider the issue of ecomaterials. 5 refs., 4 figs., 5 tabs.

  9. Groundwater pollution by arsenic and its effect on health. Present state of groundwater pollution by arsenic and its environmental quality standard; Hiso ni yoru chikasui osen to kenko eikyo

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, N.


    Resorted the official data of groundwater inspections in Japan for fiscal 1995 in accordance with the new environmental quality standard (revised in 1997), the largest number of samples that exceeded the standard values among 23 inspection items of substances was of arsenic (As: standard 0.01mg/l). In this case, 49 samples out of total 2720 samples exceeded the standard values due to As (excess ratio 1.8%). The next substances having high excess ratio were four organic chlorine compounds which are widely used as detergent (excess ratio 0.6-0.1%), and next to these was lead (0.1%). About the other substances, excess was not found. The birthplaces of the above 48 samples were as follows: Fukuoka prefecture (12 samples), Chiba (19), Saitama (7), Gunma (4), Miyagi (4), Niigata (3), Hokkaido (2), Yamagata (1, the followings were also the same), Tokyo, Aichi, Osaka, Hyogo, Tottori. Recently, arsenic poisoning in Bangladesh has been reported, and the cause of it is estimated as excessive pumping up of irrigation water. In Japan, future strengthening of surveillance is expected. 2 figs., 5 tabs.

  10. Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization. (United States)

    Gessel, Megan Murray; Bernstein, Summer; Kemper, Martin; Teplow, David B; Bowers, Michael T


    Although most cases of Alzheimer's disease (AD) are sporadic, ∼5% of cases are genetic in origin. These cases, known as familial Alzheimer's disease (FAD), are caused by mutations that alter the rate of production or the primary structure of the amyloid β-protein (Aβ). Changes in the primary structure of Aβ alter the peptide's assembly and toxic activity. Recently, a primary working hypothesis for AD has evolved where causation has been attributed to early, soluble peptide oligomer states. Here we posit that both experimental and pathological differences between FAD-related mutants and wild-type Aβ could be reflected in the early oligomer distributions of these peptides. We use ion mobility-based mass spectrometry to probe the structure and early aggregation states of three mutant forms of Aβ40 and Aβ42: Tottori (D7N), Flemish (A21G), and Arctic (E22G). Our results indicate that the FAD-related amino acid substitutions have no noticeable effect on Aβ monomer cross section, indicating there are no major structural changes in the monomers. However, we observe significant changes to the aggregation states populated by the various Aβ mutants, indicating that structural changes present in the monomers are reflected in the oligomers. Moreover, the early oligomer distributions differ for each mutant, suggesting a possible structural basis for the varied pathogenesis of different forms of FAD.

  11. Kinetics of the Interactions between Copper and Amyloid-β with FAD Mutations and Phosphorylation at the N terminus. (United States)

    Girvan, Paul; Miyake, Toru; Teng, Xiangyu; Branch, Thomas; Ying, Liming


    Mutations and post-translational modifications of amyloid-β (Aβ) peptide in its N terminus have been shown to increase fibril formation, yet the molecular mechanism is not clear. Here we investigated the kinetics of the interactions of copper with two Aβ peptides containing Familial Alzheimer's disease (FAD) mutations (English (H6R) and Tottori (D7N)), as well as with Aβ peptide phosphorylated at serine 8 (pS8). All three peptides bind to copper with a similar rate as the wild-type (wt). The dissociation rates follow the order pS8>H6R>wt>D7N; the interconversion between the two coordinating species occurs 50 % faster for H6R and pS8, whereas D7N had only a negligible effect. Interestingly, the rate of ternary complex (copper-bridged heterodimer) formation for the modified peptides was significantly faster than that for wt, thus leading us to propose that FAD and sporadic AD might share a kinetic origin for the enhanced oligomerisation of Aβ.

  12. Inverse relationship of cardioankle vascular index with BMI in healthy Japanese subjects: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Nagayama D


    Full Text Available Daiji Nagayama,1,2 Haruki Imamura,2 Yuta Sato,2 Takashi Yamaguchi,2 Noriko Ban,2 Hidetoshi Kawana,2 Masahiro Ohira,2 Atsuhito Saiki,2 Kohji Shirai,3 Ichiro Tatsuno2 1Center of Endocrinology and Metabolism, Shin-Oyama City Hospital, Oyama-City, 2Center of Diabetes, Endocrinology and Metabolism, 3Department of Vascular Function, Sakura Medical Center, Toho University, Sakura-City, Japan Objective: The objective of this study is to investigate the association of body mass index (BMI with arterial stiffness assessed by cardioankle vascular index (CAVI. Subjects and methods: A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1 ± 12.5 years, BMI 22.9 ± 3.4 kg/m2 who underwent health screening between 2004 and 2006 in Japan. Exclusion criteria were current medication use and a past history of cardiovascular disease, hypertension, stroke, diabetes, and nephritis. Results: Male subjects showed significantly higher BMI, CAVI, and triglycerides and lower high-density lipoprotein (HDL-cholesterol compared with female subjects. Next, the subjects were divided into tertiles of BMI: lower, middle, and upper, in a gender-specific manner. After adjusting for confounders including age, systolic blood pressure, and HDL-cholesterol identified by multiple regression analysis, the mean CAVI decreased progressively as BMI tertile increased in both genders. Furthermore, a negative inverse relationship between BMI and adjusted CAVI was observed throughout the BMI distribution. Multivariate logistic regression model for contributors of high CAVI (≥90th percentile identified obesity (odds ratios (95% confidence interval: 0.804 (0.720–0.899], older age [15.6 (14.0–17.4], male gender [2.26 (2.03–2.51], hypertension [2.28 (2.06–2.54], impaired fasting glucose [1.17 (1.01–1.37], and low HDL-cholesterol [0.843 (0.669–1.06] as independent factors. Conclusion: We demonstrated an

  13. WELCOME ADDRESS: Welcome Address for the 60th Yamada Conference (United States)

    Fukuyama, Hidetoshi


    discussions in the conference rooms but also through pleasant chatting on the lobby floor or even at the banquet table, which may give rise to other important international collaborative projects in the near future. Finally, we would like to express our sincere thanks to Professor Mitsuhiro Motokawa and the members of the organizing committee who have made every effort to bring in such a successful performance of the Conference. I hope all of you would enjoy the Conference and relax sometime staying in this interesting scientific city of Sendai. Thank you. Hidetoshi Fukuyama On behalf of Director General, Professor Yasusada Yamada Yamada Science Foundation

  14. The diagnostic value of endothelial function as a potential sensor of fatigue in health

    Directory of Open Access Journals (Sweden)

    Yoshiko Ohno


    Full Text Available Yoshiko Ohno1,2, Teruto Hashiguchi1, Ryuichi Maenosono1, Hidetoshi Yamashita3, Yukio Taira3, Kazufumi Minowa3, Yoshihito Yamashita3, Yuko Kato3, Ko-ichi Kawahara1, Ikuro Maruyama11Department of Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, Kagoshima Prefecture, Japan; 2Department of Community Health Nursing/Nursing Informatics, School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima City, Kagoshima Prefecture, Japan; 3Kagoshima Seikyo General Hospital, Kagoshima City, Kagoshima Prefecture, JapanPurpose: Many epidemiological research studies have shown that vital exhaustion and psychosocial factors are associated with the occurrence of cerebrocardiovascular disease (CCVD. Fatigue is thought to induce endothelial dysfunction and may be linked to the occurrence of CCVD; however, no studies have investigated this potential link. We studied to determine the effect of fatigue on endothelial function in healthy subjects with no traditional CCVD risk factors or potential confounding factors to be controlled.Subjects and methods: Peripheral arterial tonometry (PAT was used to evaluate endothelial function. The influence of the following parameters on endothelial function was analyzed in 74 office workers without traditional CCVD risk factors at health check-ups: endothelial function before and after work, subjective fatigue, lifestyle factors such as sleeping time, and psychosocial factors such as depression and social support.Results: Twenty-five subjects (33.8% had low endothelial function; reactive hyperemia (RH-PAT index <1.67, even though no abnormalities were reported in the health check-ups. There was no significant difference in endothelial function before versus after labor. Of note, endothelial function was associated with the individual’s level of subjective fatigue (t = 2.98, P = 0.008 and showed a daily fluctuation, sometimes to a pathological

  15. CALL FOR PAPERS: Special issue on Spin Glasses (United States)

    Coolen, Ton; Nishimori, Hidetoshi; Sourlas, Nicolas; Wong, Michael


    This is a call for contributions to a special issue of Journal of Physics A: Mathematical and Theoretical dedicated to the subject of the conference `Viewing The World Through Spin Glasses', in honour of David Sherrington on the occasion of his 65th birthday, 31 August-1 September 2007 (\\verb.~.ppzjpg/DS2007/). Invited speakers and participants at that meeting and other researchers working in the field are invited to submit a research paper to this issue. The Editorial Board has invited Ton Coolen, Hidetoshi Nishimori, Nicolas Sourlas and Michael Wong to serve as Guest Editors for the special issue. Their criteria for acceptance of contributions are as follows: •The subject of the paper should relate to the subject of the conference (see the website of the conference\\verb.~.ppzjpg/DS2007/). •Contributions will be refereed and processed according to the usual procedure of the journal. •Conference papers may be based on already published work but should either contain significant additional new results and/or insights or give a survey of the present state of the art, a critical assessment of the present understanding of a topic, and a discussion of open problems. •Papers submitted by non-participants should be original and contain substantial new results. The guidelines for the preparation of contributions are the following: •The DEADLINE for submission of contributions is 1 December 2007. This deadline will allow the special issue to appear in July 2008. •There is a nominal page limit of 16 printed pages per contribution. For papers exceeding this limit, the Guest Editors reserve the right to request a reduction in length. •Further advice on publishing your work in Journal of Physics A: Mathematical and Theoretical may be found at •Contributions to the special issue should, if possible, be submitted electronically by web upload at or by

  16. The reasons for triple therapy in stable COPD patients in Japanese clinical practice

    Directory of Open Access Journals (Sweden)

    Miyazaki M


    Full Text Available Masaki Miyazaki,1 Hidetoshi Nakamura,1,2 Saeko Takahashi,1 Shotaro Chubachi,1 Mamoru Sasaki,1 Mizuha Haraguchi,1 Hideki Terai,1 Makoto Ishii,1 Koichi Fukunaga,1 Sadatomo Tasaka,1 Kenzo Soejima,1 Koichiro Asano,3 Tomoko Betsuyaku1 On behalf of the Keio COPD Comorbidity Research (K-CCR group 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 2Department of Respiratory Medicine, Saitama Medical University, Saitama, 3Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan Background: Triple combination therapy involving long-acting muscarinic antagonists long-acting β2 agonists, and inhaled corticosteroids has recently become an option for maintenance treatment of COPD. Some add-on clinical trials have reported the benefits of these combinations. However, the process to step up to triple therapy varies for individual cases.Methods: Keio University and affiliated hospitals conducted an observational COPD cohort study, recruiting patients diagnosed as having COPD by pulmonary physicians and those referred for investigation of possible COPD. Their prescription history and clinical course were retrospectively analyzed based on the physicians’ medical records and patient questionnaires. This study was registered with UMIN (UMIN000003470, April 10, 2010.Results: A total of 95 of the 445 COPD patients (21% were treated with inhaled corticosteroids/long-acting β2 agonists/long-acting muscarinic antagonists as maintenance therapy, including 12 in COPD Grade I, 31 in Grade II, 38 in Grade III, and 14 in Grade IV, based on the Global Initiative for Chronic Obstructive Lung Disease spirometric grading. For more than half of the patients on triple therapy, the treatment had been intensified due to unsatisfactory improvement of symptoms, and 32% were treated with triple therapy due to comorbid asthma. In contrast, there were COPD patients whose therapy was

  17. New particle formation events as a source for cloud condensation nuclei in an urban environment (United States)

    Wonaschütz, Anna; Burkart, Julia; Wagner, Robert; Reischl, Georg; Steiner, Gerhard; Hitzenberger, Regina


    Nucleation and growth events have been observed in many remote, urban and rural environments. The new particles can contribute significantly to cloud condensation nuclei concentrations, after growing into the appropriate size range (Kerminen et al., 2012). Several studies have attempted to quantify this contribution (e.g. Asmi et al., 2011, Matsui et al., 2013), but only a limited number of them to date have used simultaneous measurements of CCN concentrations and particle size distributions for this purpose (e.g. Levin et al., 2012). In this study, a data set from an urban background station, consisting of 22 months of size distribution and 12 months of CCN concentration measurements (Burkart et al., 2011, Burkart et al., 2012) with 10 months of overlapping measurements is combined to explore the variability of CCN concentrations, their possible causes, and the contribution of nucleation and growth events to CCN concentrations. Consistent with observations in many other locations, nucleation and growth events occur on 30% of all days in spring and summer, on 11% of days in fall and on 4% of days in winter. This suggests a potentially large source of CCN from nucleation and growth events, particularly in the warm season. We acknowledge funding from FWF (Austrian Science Fund) P19515-N20 References: Asmi E., Kivekas, N., Kerminen, V. M., Komppula, M., Hyvarinen, A. P., Hatakka, J., Viisanen, Y., and Lihavainen, H.: Secondary new particle formation in Northern Finland Pallas site between the years 2000 and 2010, Atmos. Chem. Phys., 11, 12959-12972, doi: 10.5194/acp-11-12959-2011, 2011 Burkart J., Steiner, G., Reischl, G., and Hitzenberger, R.: Long-term study of cloud condensation nuclei (CCN) acticvation of the atmospheric aerosol in Vienna, Atmos. Environ., 45, 5751-5759, doi: 10.1016/j.atmosenv.2011.07.022, 2011. Burkart J., Hitzenberger, R., Reischl, G., Bauer, H., Leder, K., and Puxbaum, H.: Activation of "synthetic ambient" aerosols - relation to chemical


    Institute of Scientific and Technical Information of China (English)

    SONG; Wen-gang


    [1]Meyer Zum Buschenfelde C, Cramer S, Trumpfheller C, et al. Trypanosoma cruzi induces strong IL-12 and IL-18 gene expression in vivo: correlation with interferon-gamma (IFN-gamma) production [J]. Clin Exp Immunol 1997; 110:378.[2]Tominaga K, Yoshimoto T, Torigoe K, et al. IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells [J]. Int Immunol 2000; 12:151.[3]Takeda K, Tsutsui H, Yoshimoto T, et al. Defective NK cell activity and Th1 response in IL-18-deficient mice [J]. Immunity 1998; 8:383.[4]Tomura M, Zhou XY, Maruo S, et al. A critical role for IL-18 in the proliferation and activation of NK1.1+ CD3- cells [J]. J Immunol 1998; 160:4738.[5]Okamura H, Kashiwamura S, Tsutsui H, et al. Regulation of interferon-gamma production by IL-12 and IL-18 [J]. Curr Opin Immunol 1998; 10:259.[6]Osaki T, Hashimoto W, Gambotto A, et al. Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18) [J]. Gene Ther 1999; 6:808.[7]Dinarello CA. IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family [J]. J Allergy Clin Immunol 1999; 103:11.[8]Matsui K, Yoshimoto T, Tsutsui H, et al. Propionibacterium acnes treatment diminishes CD4+ NK1.1+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells [J]. J Immunol 1997; 159:97.[9]Akira S. The role of IL-18 in innate immunity [J]. Curr Opin Immunol 2000; 12:59.[10]Lauwerys BR, Garot N, Renauld JC, et al. Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18 [J]. J Immunol 2000; 165:1847.[11]Micallef MJ, Yoshida K, Kawai S, et al. In vivo antitumor effects of murine interferon-gamma-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites [J]. Cancer Immunol Immunother 1997; 43:361.[12]Micallef MJ, Tanimoto T

  19. Hedgehog pathway as a drug target: Smoothened inhibitors in development

    Directory of Open Access Journals (Sweden)

    Lin TL


    Full Text Available Tara L Lin1, William Matsui21Division of Hematology/Oncology, Department of Internal Medicine, University of Kansas, Kansas City, MO, USA; 2Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Emerging laboratory and clinical investigations demonstrate that Hedgehog signaling (Hh represents a novel therapeutic target in various human cancers. This conserved signaling pathway precisely regulates self-renewal and terminal differentiation in embryonic development, but is typically silenced in adult tissues, with reactivation usually only during tissue repair. Aberrant Hh pathway signaling has been implicated in the pathogenesis, self-renewal, and chemotherapy resistance of a growing number of solid and hematologic malignancies. Major components of the Hh pathway include the Hh ligands (Sonic, Desert, and Indian, the transmembrane receptor Patched, the signal transducer Smoothened (Smo, and transcription factors Gli1–3 which regulate the transcription of Hh target genes. Mutations in Hh pathway genes, increased Hh signaling in tumor stroma, and Hh overexpression in self-renewing cells (cancer stem cells have been described, and these different modes of Hh signaling have implications for the design of Hh pathway inhibitors and their integration into conventional treatment regimens. Discovery of a naturally-occurring Smo inhibitor, cyclopamine, and the identification of Hh pathway mutations and over expression in cancer cells prompted the development of several cyclopamine derivatives. Encouraging laboratory and in vivo data has resulted in Phase I and II clinical trials of Smo inhibitors. In this review, we will discuss the current understanding of Hh pathway signaling in malignancy and Smo antagonists in development. Recent data with these agents shows that they are well-tolerated and may be effective for subsets of patients. Challenges remain

  20. Skyrmion crystal and topological Hall effect in B20-type transition-metal compounds (United States)

    Onose, Yoshinori


    Topological objects in solids such as domain walls and vortices have been attracting much attention for long. Among them the spin texture called skyrmion is an unusual topological object, in which the spins point in all the directions wrapping a sphere. The skyrmion hosts finite spin chirality, and therefore is anticipated to induce novel electromagnetic phenomena such as topological Hall effect. In B20-type transition metal compounds MnSi and Fe 1-x Co x Si, the crystallization of skyrmions was observed by the neutron diffraction studies. , . Recently, we have observed the real-space images of skyrmion crystal in thin films of related compounds (Fe 0.5 Co 0.5 Si and FeGe) using Lorentz transmission electron spectroscopy., Nature material, inpress.} We have observed the hexagonal arrangement of skyrmions including the topological defects (chiral domains and dislocations) under the magnetic field normal to the films, and found that the two dimensional skyrmion crystal phase is fairly stabilized by the thin film form of the samples. We have also studied the topological Hall effect caused by the spin chirality of the skyrmion crystal in a related material MnGe. In terms of the Hall measurement, they have shown the real space nature of the fictitious magnetic field caused by the magnetic configuration of the skyrmion crystal, in contrast with the momentum-space fictitious field in another spin chirality system, Nd 2 Mo 2 O7 . This work was done in collaboration with X. Z. Yu, N. Kanazawa, J. H. Park, J. H. Han, K. Kimoto, W. Z. Zhang, S. Ishiwata, Y. Matsui, N. Nagaosa, and Y. Tokura. S. Mühlbauer et al. Science 323, 915 (2009).}

  1. Persistent corneal epithelial defect responding to rebamipide ophthalmic solution in a patient with diabetes

    Directory of Open Access Journals (Sweden)

    Hayashi Y


    Full Text Available Yusuke Hayashi, Hiroshi Toshida, Yusuke Matsuzaki, Asaki Matsui, Toshihiko Ohta Department of Ophthalmology, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, Japan Objective: Rebamipide ophthalmic suspension was developed for the treatment of dry eyes and for other corneal diseases, promoting the secretion of both mucin in tear fluid and membrane-associated mucin, increasing the number of goblet cells, and restoring the barrier function of the corneal epithelium. We report a case of a persistent corneal epithelial defect in a patient with diabetes treated with topical application of rebamipide ophthalmic suspension. Case presentation: A 73-year-old woman had a history of type 2 diabetes for 35 years and nonproliferative diabetic retinopathy for 23 years. She presented to our department with discharge and ophthalmalgia in the left eye. A corneal ulcer was detected, and culture of corneal scrapings was performed, with Staphylococcus aureus and Streptococcus canis being isolated. The infection was treated with levofloxacin eye drops and ofloxacin ophthalmic ointment based on the sensitivity profile of the isolate. However, a corneal epithelial defect persisted for approximately 2 months despite continuing treatment with 0.1% hyaluronic acid ophthalmic suspension and 0.3% ofloxacin eye ointment. Her hemoglobin A1c was 7.3%. The persistent corneal epithelial defect showed improvement at 2 weeks after treatment with rebamipide unit dose 2% ophthalmic suspension, and it did not recur even when vitrectomy was subsequently performed for vitreous hemorrhage due to progression of diabetic retinopathy. Conclusion: This is the first report about efficacy of rebamipide unit dose 2% ophthalmic suspension for presenting persistent corneal epithelial defect in a patient with diabetes. In the present case, the suggested mechanisms are the following: improving the corneal barrier function, stabilization of mucin on the keratoconjunctival epithelium, and

  2. Use of DOE SGP Radars in Support of ASR Modeling Activities

    Energy Technology Data Exchange (ETDEWEB)

    Rutledge, Steven A. [Colorado State Univ., Fort Collins, CO (United States)


    The objective of this work was to use the DOE Southern Great Plains (SGP) precipitation radars to investigate physical characteristics of clouds and precipitation, and use this knowledge in support of DOE ASR modeling efforts. The goal was to develop an integrated data set based on the SGP instrumentation to yield statistically robust fields to aid in the task of verifying simulated cloud dynamical and microphysical fields. For this effort we relied heavily on the ARM scanning precipitation radars, X-SAPR’s and C-SAPR, and also incorporating data from wind profilers, surface disdrometers and the nearby WSR-88D radar, KVNX. Initially we lent our expertise to quality controlling the data from the newly installed ARM radars, particularly the X-band polarimetric data, and additionally assessed automatic radial velocity unfolding algorithms developed by other ASR researchers. We focused our efforts on four cases from the MC3E field campaign in 2011 and developed a dataset including microphysical information derived from hydrometeor identification and kinematic analysis using multiple-Doppler retrieval techniques. This dataset became a PI product and was released to the community in 2014. This analysis was used to investigate the source of big drops (> 5 mm) observed with disdrometers at the surface. It was found that the big drops were coincident with the strongest updrafts, suggesting they resulted from the melting of large precipitation ice, likely hail. We teamed up with W-K Tao and T. Matsui to statistically compare radar-derived observational kinematics and microphysics to WRF model output for the 25 April 2011. Comparisons highlighted some areas where the model may need improvement, such as generating too much hail and big drops, as well as overly-strong updrafts and overly-weak of downdrafts.

  3. Comparison of clinical features between primary and drug-induced sleep-related eating disorder

    Directory of Open Access Journals (Sweden)

    Komada Y


    Full Text Available Yoko Komada,1 Yoshikazu Takaesu,2 Kentaro Matsui,3 Masaki Nakamura,3 Shingo Nishida,3 Meri Kanno,3,† Akira Usui,3 Yuichi Inoue1,3 1Department of Somnology, 2Department of Psychiatry, Tokyo Medical University, 3Japan Somnology Center, Institute of Neuropsychiatry, Tokyo, Japan †Meri Kanno passed away on March 1, 2016 Purpose: The aim of this study was to ascertain the clinical characteristics of drug-induced sleep-related eating disorder (SRED. Patients and methods: We retrospectively reviewed the medical records of 30 patients with primary SRED (without any comorbid sleep disorders and who were not taking any possible causative medications, and ten patients with drug-induced SRED (occurrence of SRED episodes after starting nightly medication of sedative drugs, which completely resolved after dose reduction or discontinuation of the sedatives. Results: All patients with drug-induced SRED took multiple types of sedatives, such as benzodiazepines or benzodiazepine receptor agonists. Clinical features of drug-induced SRED compared with primary SRED were as follows: higher mean age of onset (40 years old in drug-induced SRED vs 26 years old in primary SRED, significantly higher rate of patients who had total amnesia during most of their SRED episodes (75.0% vs 31.8%, significantly lower rate of comorbidity of night eating syndrome (0% vs 63.3%, and significantly lower rate of history of sleepwalking (10.0% vs 46.7%. Increased doses of benzodiazepine receptor agonists may be responsible for drug-induced SRED. Conclusion: The clinical features of drug-induced SRED were different from those of primary SRED, possibly reflecting differences in the underlying mechanisms between these two categories of SREDs. Keywords: nocturnal eating syndrome, night eating, eating disorder, hypnotics, amnesia, sleepwalking, benzodiazepine

  4. Focal Mechanism of Semi-Volcanic Deep Low-Frequency Earthquakes in Eastern Shimane (United States)

    Aso, N.; Ohta, K.; Ide, S.


    Many deep low-frequency earthquakes (LFEs) occur near the island arc Mohorovicic discontinuities and far from both active volcanoes and plate boundaries. They are quite similar to volcanic LFEs beneath active volcanoes, which infers some fluid movement in the source region, and we regard them as "semi-volcanic" LFEs [Aso et al., 2011; 2012 (submitted)]. Several previous studies determined the focal mechanisms of volcanic and semi-volcanic LFEs using a small portion of information of the waveforms. Although the estimated focal mechanisms are various, they may not necessary support the variety of the actual physical process, owing to the large determination error [e.g., Nishidomi and Takeo, 1996; Ohmi and Obara, 2002; Nakamichi et al., 2003]. Here we determine the focal mechanisms by waveform inversion for LFEs in eastern Shimane in western Japan, where many LFEs occurred in a quiet region. The locations are also close to the fault plane of the 2000 western Tottori earthquake of Mw6.6, and right beneath Yokota volcano, which is a Quaternary volcanic cluster. We estimated the focal mechanisms of semi-volcanic LFEs in eastern Shimane by moment tensor inversion. The data are velocity seismograms at five stations of Hi-net near the epicenters. For each seismogram, we extracted a 1.5-second time window beginning from 0.2 seconds before the arrivals of either P-wave in a vertical component or S-wave in a horizontal component. The arrival time of each phase is picked manually first, and then corrected to minimize the variance between observed and synthetic waveforms. The local site amplification is estimated using far-field body waves from deep intraslab earthquakes, and collected for each seismogram. The synthetic waveforms were calculated using the discrete wavenumber integration method developed by Takeo [1985] for a horizontally layered structure. For 38 LFEs, which are equal to or larger than M1.2 (JMA magnitude) and recorded at all five stations, the focal mechanisms

  5. Isolation, characterization, and diversity of novel radiotolerant carotenoid-producing bacteria. (United States)

    Asker, Dalal; Awad, Tarek S; Beppu, Teruhiko; Ueda, Kenji


    Carotenoids are natural pigments that exhibit many biological functions, such as antioxidants (i.e., promote oxidative stress resistance), membrane stabilizers, and precursors for vitamin A. The link between these biological activities and many health benefits (e.g., anticarcinogenic activity, prevention of chronic diseases, etc.) has raised the interest of several industrial sectors, especially in the cosmetics and pharmaceutical industries. The use of microorganisms in biotechnology to produce carotenoids is favorable by consumer and can help meet the growing demand for these bioactive compounds in the food, feed, and pharmaceutical industries. This methodological chapter details the development of a rapid and selective screening method for isolation and identification of carotenoid-producing microorganisms based on UV treatment, sequencing analysis of 16S rRNA genes, and carotenoids' analysis using rapid and effective High-Performance Liquid Chromatography-Diodearray-MS methods. The results of a comprehensive 16S rRNA gene-based phylogenetic analysis revealed a diversity of carotenoid-producing microorganisms (104 isolates) that were isolated at a high frequency from water samples collected at Misasa (Tottori, Japan), a region known for its high natural radioactivity content. These carotenoid-producing isolates were classified into 38 different species belonging to 7 bacterial classes (Flavobacteria, Sphingobacteria, α-Proteobacteria, γ-Proteobacteria, Deinococci, Actinobacteria, and Bacilli). The carotenoids produced by the isolates were zeaxanthin (6 strains), dihydroxyastaxanthin (24 strains), astaxanthin (27 strains), canthaxanthin (10 strains), and unidentified molecular species that were produced by the isolates related to Deinococcus, Exiguobacterium, and Flectobacillus. Here, we describe the methods used to isolate and classify these microorganisms.

  6. Why do aftershocks occur? Relationship between mainshock rupture and aftershock sequence based on highly resolved hypocenter and focal mechanism distributions (United States)

    Yukutake, Yohei; Iio, Yoshihisa


    In order to clarify the origin of aftershocks, we precisely analyze the hypocenters and focal mechanisms of the aftershocks following the 2000 Western Tottori Earthquake, which occurred in the western part of Japan, using data from dense seismic observations. We investigate whether aftershocks occur on the mainshock fault plane on which coseismic slip occurred or they represent the rupture of fractures surrounding the mainshock fault plane. Based on the hypocenter distribution of the aftershocks, the subsurface fault structure of the mainshock is estimated using principal component analysis. As a result, we can obtain the detail fault structure composed of 8 best-fit planes. We demonstrate that the aftershocks around the mainshock fault are distributed within zones of 1.0-1.5 km in thicknesses, and their focal mechanisms are significantly diverse. This result suggests that most of the aftershocks represent the rupture of fractures surrounding the mainshock fault rather than the rerupture of the mainshock fault. The aftershocks have a much wider zone compared with the exhumed fault zone in field observations, suggesting that many aftershocks occur outside the fault damage zone. We find that most aftershocks except in and around the large-slip region are well explained by coseismic stress changes. These results suggest that the thickness of the aftershock distribution may be controlled by the stress changes caused by the heterogeneous slip distribution during the mainshock. The aftershock is also distributed within a much wider zone than the hypocenter distribution observed in swarm activity in the geothermal region, which is thought to be caused by the migration of hydrothermal fluid. This result implies a difference in generation processes: Stress changes due to the mainshock contribute primarily to the occurrence of aftershocks, whereas earthquake swarms in the geothermal region are caused by fluid migration within the localized zone. [Figure not available: see

  7. Variability of surface characteristics and energy flux patterns of sunn hemp ( Crotalaria juncea L.) under well-watered conditions (United States)

    Takagi, Keiko; Kimura, Reiji; Şaylan, Levent


    There is not much information in the literature about the energy partitioning and micrometeorological features of sunn hemp. Therefore, in this study, the variations in the energy-balance components and plant characteristics such as aerodynamic and surface conductance, crop coefficient, albedo, short- and long wave down- and upward radiation have been measured and estimated for the time period from August to October 2004 over an irrigated sand field at the Arid Land Research Center in Tottori, Japan. The Bowen ratio energy-balance method was used to calculate the partitioning of heat fluxes of sunn hemp. The Bowen ratio values at the first growing stages in August were found to be higher than the Bowen ratio values at the latest growing stages in September and October because of the heavy rain and high soil-water content. The daytime averaged Bowen ratio was 0.19. During the measurement period, the daytime average net radiation, and soil, latent and sensible heat fluxes were approximately 231, 28, 164, and 39 W m-2, respectively. The net radiation and soil heat flux showed decreasing trends from the beginning to the end of the experiment period due to the atmospheric and crop growth conditions. The daytime averages of aerodynamic and surface conductance for sunn hemp were around 31 and 17 mm s-1, respectively. Also, the daytime average albedo of sunn hemp was around 19%. Finally, the high precipitation amount due to typhoons, high soil-water content, low available energy and low vapor-pressure deficit lead to decreasing trend of the energy fluxes during the generative phase of sunn hemp.

  8. EEG Power Spectrum Analysis in Children with ADHD (United States)

    Kamida, Akira; Shimabayashi, Kenta; Oguri, Masayoshi; Takamori, Toshihiro; Ueda, Naoyuki; Koyanagi, Yuki; Sannomiya, Naoko; Nagira, Haruki; Ikunishi, Saeko; Hattori, Yuiko; Sato, Kengo; Fukuda, Chisako; Hirooka, Yasuaki; Maegaki, Yoshihiro


    Background Attention deficit disorder/hyperactivity disorder (ADHD) is a pathological condition that is not fully understood. In this study, we investigated electroencephalographic (EEG) power differences between children with ADHD and healthy control children. Methods EEGs were recorded as part of routine medical care received by 80 children with ADHD aged 4–15 years at the Department of Pediatric Neurology in Tottori University Hospital. Additionally, we recorded in 59 control children aged 4–15 years after obtaining informed consent. Specifically, awake EEG signals were recorded from each child using the international 10–20 system, and we used ten 3-s epochs on the EEG power spectrum to calculate the powers of individual EEG frequency bands. Results The powers of different EEG bands were significantly higher in the frontal brain region of those in the ADHD group compared with the control group. In addition, the power of the beta band in the ADHD group was significantly higher in all brain regions, except for the occipital region, compared with control children. With regard to developmental changes, the power of the alpha band in the occipital region showed an age-dependent decrease in both groups, with slightly lower power in the ADHD group. Additionally, the intergroup difference decreased in children aged 11 years or older. As with the alpha band in the occipital region, the beta band in the frontal region showed an age-dependent decrease in both groups. Unlike the alpha band, the power of the beta band was higher in the ADHD group than in the control group for children of all ages. Conclusion The observed intergroup differences in EEG power may provide insight into the brain function of children with ADHD. PMID:27493489

  9. Positive evolutionary selection of an HD motif on Alzheimer precursor protein orthologues suggests a functional role.

    Directory of Open Access Journals (Sweden)

    István Miklós


    Full Text Available HD amino acid duplex has been found in the active center of many different enzymes. The dyad plays remarkably different roles in their catalytic processes that usually involve metal coordination. An HD motif is positioned directly on the amyloid beta fragment (Aβ and on the carboxy-terminal region of the extracellular domain (CAED of the human amyloid precursor protein (APP and a taxonomically well defined group of APP orthologues (APPOs. In human Aβ HD is part of a presumed, RGD-like integrin-binding motif RHD; however, neither RHD nor RXD demonstrates reasonable conservation in APPOs. The sequences of CAEDs and the position of the HD are not particularly conserved either, yet we show with a novel statistical method using evolutionary modeling that the presence of HD on CAEDs cannot be the result of neutral evolutionary forces (p<0.0001. The motif is positively selected along the evolutionary process in the majority of APPOs, despite the fact that HD motif is underrepresented in the proteomes of all species of the animal kingdom. Position migration can be explained by high probability occurrence of multiple copies of HD on intermediate sequences, from which only one is kept by selective evolutionary forces, in a similar way as in the case of the "transcription binding site turnover." CAED of all APP orthologues and homologues are predicted to bind metal ions including Amyloid-like protein 1 (APLP1 and Amyloid-like protein 2 (APLP2. Our results suggest that HDs on the CAEDs are most probably key components of metal-binding domains, which facilitate and/or regulate inter- or intra-molecular interactions in a metal ion-dependent or metal ion concentration-dependent manner. The involvement of naturally occurring mutations of HD (Tottori (D7N and English (H6R mutations in early onset Alzheimer's disease gives additional support to our finding that HD has an evolutionary preserved function on APPOs.

  10. Determination of Radon concentration in air using scinti-cell radon monitor

    Energy Technology Data Exchange (ETDEWEB)

    Koga, Taeko [Kinki Univ., Higashi-Osaka, Osaka (Japan). Atomic Energy Research Inst; Morishima, Hiroshige; Arai, Naoki; Shiraishi, Masatoshi; Shigehara, Makiko [Dept. of Nuclear Engineering, School of Science and Technology, Kinki Univ., Higashi-Osaka, Osaka(Japan); Mifune, Masaaki


    This study is carried out the methodology characteristics of {sup 222}Rn (Radon) concentration in air using the scinti-cell radon monitor (Trace environmental level detector (PMT-TEL) and Lucas cell (300 A), Pylon Co. and the determination of Radon concentrations in air on Misasa spa area in Tottori pref. and Ikeda spa in Shimane pref. on November 1995 and 1996. We have reached to the following results; (1) Minimum detectable Radon concentrations in air using the scinti-cell monitor are 7.6 Bq/m{sup 3} with 23% of accuracy (relative standard deviation) on the grab sampling of Lucas cell and 0.58 Bq/m{sup 3} with that of 17% on the continuous measuring of PMT-TEL, when it measured after 3.5 hours on the air sampling to determine the mean radon concentrations. The radon concentrations by the PMT-TEL method is about ten times more detectable than those by Lucas cell, that the former is the most sensitive among the detectors used on this research and is able to detect low level environmental concentrations, particularly outdoor and the later is valuable to use conveniently and portably on grab spot sampling of high level radon concentrations indoor air. (2) On the comparison of characteristics on spot monitoring of radon in air, a pico-rad method is suitable for the determination of the mean concentration for continuous sampling period by PMT-TEL and Lucas cell 300 A, and the variation of radon concentration can be observed on elapse of time course. (author)

  11. Study on the environmental movements and distributions of natural radioactive nuclides on the granite area (II)

    Energy Technology Data Exchange (ETDEWEB)

    Morishima, Hiroshige; Koga, Taeko [Kinki Univ., Higashi-Osaka, Osaka (Japan). Atomic Energy Research Inst


    The natural radionuclides as K-40, uranium decay series and thorium decay series etc. are widely distributed on environment, but are not uniformly. These have various forms as the sources of terrecial environmental {gamma} radiation and of radon and make wide fluctuation seasonal and spatially on the environment. We have selected Ikeda mineral spring district, Shimane pref., Misasa spa district, Tottori pref., Muro district, Hachibuse district, Nara pref. and Arima spa district, Hyogo-pref. for HBRA, and Kawanishi-shi, Hyogo pref. and Higashi-osaka-shi, Osaka pref. as CA. We have carried out the study on the environmental movement and distribution of natural radioactive nuclides containing radon and decay nuclides. Radon measurements have been carried using cup typed radon and thoron monitors, pico-rad method by active charcoal sampling and Pilon scintillation-cell by grub sampling. Accumulated radon monitors have been used with cellulose nitrate as solid state track detector. Rn-222 concentrations in air at Misasa spa ranged 2 - 150 Bq/m{sup 3} outdoor and 8 - 194 Bq/m{sup 3} indoor. Rn-222 concentrations on Misasa district, Asahi district and Takeda district geologically formed from granite strata are high, and those on Osika district and Mitoku district formed from volcanic rocks (Andesite and Basalt) are low level. Rn-222 concentration variations in well water used as drinking water were 2 - 138 Bq/l (mean value 31 Bq/l) and those in ground waters varied from non detectable to 4620 Bq/l (mean 875 Bq/l) on sampling time and places. Mean Rn-222 concentration in the spring water at Arima spa area, Hyogo prefecture is 26 Bq/l at Tansan spring source and the other spring sources are comparatively low level. (J.P.N.)

  12. Validation of Broadband Ground Motion Simulations for Japanese Crustal Earthquakes by the Recipe (United States)

    Iwaki, A.; Maeda, T.; Morikawa, N.; Miyake, H.; Fujiwara, H.


    The Headquarters for Earthquake Research Promotion (HERP) of Japan has organized the broadband ground motion simulation method into a standard procedure called the "recipe" (HERP, 2009). In the recipe, the source rupture is represented by the characterized source model (Irikura and Miyake, 2011). The broadband ground motion time histories are computed by a hybrid approach: the 3-D finite-difference method (Aoi et al. 2004) and the stochastic Green's function method (Dan and Sato, 1998; Dan et al. 2000) for the long- (> 1 s) and short-period (structure model. As the engineering significance of scenario earthquake ground motion prediction is increasing, thorough verification and validation are required for the simulation methods. This study presents the self-validation of the recipe for two MW6.6 crustal events in Japan, the 2000 Tottori and 2004 Chuetsu (Niigata) earthquakes. We first compare the simulated velocity time series with the observation. Main features of the velocity waveforms, such as the near-fault pulses and the large later phases on deep sediment sites are well reproduced by the simulations. Then we evaluate 5% damped pseudo acceleration spectra (PSA) in the framework of the SCEC Broadband Platform (BBP) validation (Dreger et al. 2015). The validation results are generally acceptable in the period range 0.1 - 10 s, whereas those in the shortest period range (0.01-0.1 s) are less satisfactory. We also evaluate the simulations with the 1-D velocity structure models used in the SCEC BBP validation exercise. Although the goodness-of-fit parameters for PSA do not significantly differ from those for the 3-D velocity structure model, noticeable differences in velocity waveforms are observed. Our results suggest the importance of 1) well-constrained 3-D velocity structure model for broadband ground motion simulations and 2) evaluation of time series of ground motion as well as response spectra.

  13. [A study of Hashida Kunihiko's thought: the life history and thought of an "outcast thinker"]. (United States)

    Katsui, Keiko


    Hashida Kunihiko, described and known as "an Outcast Thinker", was born in Tottori, in 1882. From his young age, he was taught oriental thought by his father Fujita Kenzo, a practitioner of Kampo medicine. While Hashida taught physiology as a faculty member at the Imperial University of Tokyo, he studied Dogen's Zen philosophy and developed his original philosophy of science to answer the question: "What is Life/Living?". After taking the oath of office as the 56th education minister of Japan from 1940 to 1943, he committed suicide in 1945, taking the responsibility for his policy-making of nationalistic education at time of the Second World War. Some previous studies on Hashida have focused on various aspects such as his work as a physiologist, a scientist, a scholar of Zen philosophy, and an educrat. He may be well known in each of these different disciplines, whereas how these different aspects are integrated in Hashida's thought as a whole has not been clarified yet. Taking the propositions in those previous studies on him into account to totally understand Hashida as a thinker, this note will focus on the potential perspective for his undiscovered aspect: "Hashida as Medical Philosopher". Hashida has perused and loved two classical texts on oriental thought and oriental medicine, which are "Chuan Xi Lu" and "Shang Han Lun", during his lifetime and learned many things about "Medicine". He has tried to implement his philosophy of medicine to set up and maturate "Japanese medicine". Hence, to dissert "Hashida as Medical Philosopher" may become a ground for argument to understand his thought as a whole from the genetic perspective on the process of thought formation of Hashida. Therefore this note can be characterized as a preliminary survey to develop the further studies on Hashida's thought.

  14. Long-range transport of mutagens and other air pollutants from mainland East Asia to western Japan. (United States)

    Coulibaly, Souleymane; Minami, Hiroki; Abe, Maho; Hasei, Tomohiro; Oro, Tadashi; Funasaka, Kunihiro; Asakawa, Daichi; Watanabe, Masanari; Honda, Naoko; Wakabayashi, Keiji; Watanabe, Tetsushi


    Asian dust events, transport of dust particles from arid and semi-arid areas in China and Mongolia to the east by prevailing westerlies, are often observed in Japan in spring. In recent decades, consumption of fossil fuels has markedly increased in mainland East Asia with rapid economic growth, and severe air pollution has occurred. A part of air pollutants including mutagens, such as polycyclic aromatic hydrocarbons (PAHs), generated in mainland East Asia are thought to be transported to Japan by the prevailing westerlies, like Asian dust, and winter monsoon. The objective of this study was to clarify the long-range transport of mutagens and other air pollutants in East Asia. Thus, we collected total suspended particles (TSP) at a rural town in western Japan, namely, Yurihama in Tottori Prefecture, for 1 year (June 2012-May 2013), and investigated their chemical constituents and mutagenicity. Many TSP collected from January to March showed high mutagenicity toward Salmonella typhimurium YG1024 with and without S9 mix, and high levels of lead (Pb) and sulfate ions (SO4 (2-)), which are indicators of transboundary air pollutions from mainland East Asia, were detected in those TSP. A large amount of iron, which is an indicator of sand, was found in highly mutagenic TSP collected in March, but not in TSP collected in January and February. High levels of PAHs were detected in highly mutagenic TSP collected from January to March. The ratios of the concentration of fluoranthene to those of fluoranthene and pyrene suggested that the main source of PAHs in TSP collected in winter and spring was coal and biomass combustion. Backward trajectories of air masses on days when high levels of mutagenicity were found indicated that these air masses had traveled from eastern or northern China to Yurihama. These results suggest that high levels of mutagens were transported from mainland East Asia to western Japan, and this transportation accompanied Asian dust in March, but not in

  15. Estimation of caffeine intake in Japanese adults using 16 d weighed diet records based on a food composition database newly developed for Japanese populations. (United States)

    Yamada, Mai; Sasaki, Satoshi; Murakami, Kentaro; Takahashi, Yoshiko; Okubo, Hitomi; Hirota, Naoko; Notsu, Akiko; Todoriki, Hidemi; Miura, Ayako; Fukui, Mitsuru; Date, Chigusa


    Previous studies in Western populations have linked caffeine intake with health status. While detailed dietary assessment studies in these populations have shown that the main contributors to caffeine intake are coffee and tea, the wide consumption of Japanese and Chinese teas in Japan suggests that sources of intake in Japan may differ from those in Western populations. Among these teas, moreover, caffeine content varies widely among the different forms consumed (brewed, canned or bottled), suggesting the need for detailed dietary assessment in estimating intake in Japanese populations. Here, because a caffeine composition database or data obtained from detailed dietary assessment have not been available, we developed a database for caffeine content in Japanese foods and beverages, and then used it to estimate intake in a Japanese population. The caffeine food composition database was developed using analytic values from the literature, 16 d weighed diet records were collected, and caffeine intake was estimated from the 16 d weighed diet records. Four areas in Japan, Osaka (Osaka City), Okinawa (Ginowan City), Nagano (Matsumoto City) and Tottori (Kurayoshi City), between November 2002 and September 2003. Two hundred and thirty Japanese adults aged 30-69 years. Mean caffeine intake was 256.2 mg/d for women and 268.3 mg/d for men. The major contributors to intake were Japanese and Chinese teas and coffee (47 % each). Caffeine intake above 400 mg/d, suggested in reviews to possibly have negative health effects, was seen in 11 % of women and 15 % of men. In this Japanese population, caffeine intake was comparable to the estimated values reported in Western populations.

  16. Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8 (United States)

    Watanabe, Masanari; Noma, Hisashi; Kurai, Jun; Sano, Hiroyuki; Kitano, Hiroya; Saito, Rumiko; Kimura, Yutaka; Aiba, Setsuya; Oshimura, Mitsuo; Shimizu, Eiji


    This study aimed to investigate the effects of particulate matter (PM) on pulmonary function in schoolchildren, as well as the relationships of these effects with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children during April–May 2012, and in 384 of these children during March–May 2013. PEF’s association with the daily levels of suspended particulate matter (SPM) and PM < 2.5 μm (PM2.5) was estimated using a linear mixed model. Interleukin-8 promoter activity was assessed in THP-G8 cells stimulated by fallen PM collected at Tottori University Hospital during four periods (two in 2012 and two in 2013). An increase of 14.0 μg/m3 in SPM led to PEF changes of −2.16 L/min in 2012 and −0.81 L/min in 2013, respectively. An increment of 10.7 μg/m3 in PM2.5 was associated with PEF changes of −2.58 L/min in 2012 and −0.55 L/min in 2013, respectively. These associations were only significant in 2012. Interleukin-8 promoter activity was significantly higher in both periods of 2012 than in 2013. There was a significant association between pulmonary function in schoolchildren and daily levels of SPM and PM2.5, but this association may differ depending on the PM’s ability to elicit interleukin-8 production. PMID:26569272

  17. Cluster Analysis of Velocity Field Derived from Dense GNSS Network of Japan (United States)

    Takahashi, A.; Hashimoto, M.


    Dense GNSS networks have been widely used to observe crustal deformation. Simpson et al. (2012) and Savage and Simpson (2013) have conducted cluster analyses of GNSS velocity field in the San Francisco Bay Area and Mojave Desert, respectively. They have successfully found velocity discontinuities. They also showed an advantage of cluster analysis for classifying GNSS velocity field. Since in western United States, strike-slip events are dominant, geometry is simple. However, the Japanese Islands are tectonically complicated due to subduction of oceanic plates. There are many types of crustal deformation such as slow slip event and large postseismic deformation. We propose a modified clustering method of GNSS velocity field in Japan to separate time variant and static crustal deformation. Our modification is performing cluster analysis every several months or years, then qualifying cluster member similarity. If a GNSS station moved differently from its neighboring GNSS stations, the station will not belong to in the cluster which includes its surrounding stations. With this method, time variant phenomena were distinguished. We applied our method to GNSS data of Japan from 1996 to 2015. According to the analyses, following conclusions were derived. The first is the clusters boundaries are consistent with known active faults. For examples, the Arima-Takatsuki-Hanaore fault system and the Shimane-Tottori segment proposed by Nishimura (2015) are recognized, though without using prior information. The second is improving detectability of time variable phenomena, such as a slow slip event in northern part of Hokkaido region detected by Ohzono et al. (2015). The last one is the classification of postseismic deformation caused by large earthquakes. The result suggested velocity discontinuities in postseismic deformation of the Tohoku-oki earthquake. This result implies that postseismic deformation is not continuously decaying proportional to distance from its epicenter.

  18. Prevalence of drug resistance and culture-positive rate among microorganisms isolated from patients with ocular infections over a 4-year period

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    Shimizu Y


    Full Text Available Yusuke Shimizu,1 Hiroshi Toshida,1 Rio Honda,1 Asaki Matsui,1 Toshihiko Ohta,1 Yousuke Asada,2 Akira Murakami2 1Department of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka, Japan; 2Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan Purpose: To investigate the microbial isolates from patients with ocular infections and the trend in the emergence of levofloxacin-resistant strains over the past four years from 2006 to 2009 retrospectively. Patients and methods: The subjects were 242 patients with ocular infections or traumas treated in our hospital including outpatients, inpatients, and emergency room patients. Most of them needed urgent care presenting with eye complaints, traumas, or decreased vision. Clinical samples were obtained from discharges, corneal, conjunctival tissues or vitreous fluid or aqueous humor, and cultured. Items for assessment included the patient’s age, the diagnosis, the prevalence of isolated bacteria, and the results of susceptibility tests for levofloxacin (LVFX cefamezin (CEZ, gentamicin (GM and vancomycin. This information was obtained from the patients’ medical records. Results: There were 156 male patients and 86 female patients who were aged from 2 months old to 94 years old and mean age was 56.8 ± 24.2 years. Of the 242 patients, 78 (32.2% had positive cultures. The culture-positive rate was significantly higher in male patients than female in total (P = 0.002 and in patients with corneal perforation (P = 0.005. Corneal perforation was the highest culture-positive rate (60.0%, followed by orbital cellulitis (56.5%, blepharitis (50.0%, dacryoadenitis (45.5%, conjunctivitis (38.2%, infectious corneal ulcer (28.5% and endophthalmitis (24.7%. LVFX-resistant strains accounted for 40 out of a total of 122 strains (32.8%, and the minimum inhibitory concentration (MIC was significantly higher in LVFX and GM compared with the other antibiotics. There were no vancomycin

  19. Elevation of urinary liver-type fatty acid binding protein after cardiac catheterization related to cardiovascular events

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    Kamijo-Ikemori A


    Full Text Available Atsuko Kamijo-Ikemori,1,3 Nobuyuki Hashimoto,2 Takeshi Sugaya,1 Katsuomi Matsui,1 Mikako Hisamichi,1 Yugo Shibagaki,1 Fumihiko Miyake,2 Kenjiro Kimura1 1Department of Nephrology and Hypertension, 2Department of Cardiology, 3Department of Anatomy, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan Purpose: Contrast medium (CM induces tubular hypoxia via endothelial damage due to direct cytotoxicity or viscosity. Urinary liver-type fatty acid binding protein (L-FABP increases along with tubular hypoxia and may be a detector of systemic circulation injury. The aim of this study was to evaluate the clinical usefulness of detecting increases in urinary L-FABP levels due to administration of CM, as a prognostic biomarker for cardiovascular disease in patients without occurrence of CM-induced nephropathy undergoing cardiac catheterization procedure (CCP. Methods: Retrospective longitudinal analyses of the relationship between urinary L-FABP levels and occurrence of cardiovascular events were performed (n=29. Urinary L-FABP was measured by ELISA before CCP, and at 6, 12, 24, and 48 hours after CCP. Results: Urinary L-FABP levels were significantly higher at 12 hours (P<0.05 and 24 hours (P<0.005 after CCP compared with before CCP, only in the patients with occurrence of cardiovascular events (n=17, but not in those without cardiovascular events (n=12. The parameter with the largest area under the curve (0.816 for predicting the occurrence of cardiovascular events was the change in urinary L-FABP at 24 hours after CCP. The difference in urinary L-FABP levels (ΔL-FABP ≥11.0 µg/g creatinine between before CCP and at 24 hours after CCP was a risk factor for the occurrence of cardiovascular events (hazard ratio, 4.93; 95% confidence interval, 1.27–19.13; P=0.021. Conclusion: Measurement of urinary L-FABP before CCP and at 24 hours after CCP in patients with mild to moderate renal dysfunction may be an important indicator for risk

  20. Downscaling and hydrological uncertainties in 20th century hydrometeorological reconstructions over France (United States)

    Vidal, Jean-Philippe; Caillouet, Laurie; Dayon, Gildas; Boé, Julien; Sauquet, Eric; Thirel, Guillaume; Graff, Benjamin


    The record length of streamflow observations is generally limited to the last 50 years, which is not enough to properly explore the natural hydrometeorological variability, a key to better understand the effects of anthropogenic climate change. This work proposes a comparison of different hydrometeorological reconstruction datasets over France built on the downscaling of the NOAA 20th century global extended reanalysis (20CR, Compo et al., 2011). It aims at assessing the uncertainties related to these reconstructions and improving our knowledge of the multi-decadal hydrometeorological variability over the 20th century. High-resolution daily meteorological reconstructions over the period 1871-2012 are obtained with two statistical downscaling methods based on the analogue approach: the deterministic ANALOG method (Dayon et al., 2015) and the probabilistic SCOPE method (Caillouet et al., 2016). These reconstructions are then used as forcings for the GR6J lumped conceptual rainfall-runoff model and the SIM physically-based distributed hydrological model, in order to derive daily streamflow reconstructions over a set of around 70 reference near-natural catchments. Results show a large multi-decadal streamflow variability over the last 140 years, which is however relatively consistent over France. Empirical estimates of three types of uncertainty - structure of the downscaling method, small-scale internal variability, and hydrological model structure - show roughly equal contributions to the streamflow uncertainty at the annual time scale, with values as high as 20% of the interannual mean. Caillouet, L., Vidal, J.-P., Sauquet, E., and Graff, B.: Probabilistic precipitation and temperature downscaling of the Twentieth Century Reanalysis over France, Clim. Past, 12, 635-662, doi:10.5194/cp-12-635-2016, 2016. Compo, G. P., Whitaker, J. S., Sardeshmukh, P. D., Matsui, N., Allan, R. J., Yin, X., Gleason, B. E., Vose, R. S., Rutledge, G., Bessemoulin, P., Brönnimann, S

  1. Variability of cyclones over the North Atlantic and Europe since 1871 (United States)

    Welker, C.; Martius, O.


    The scarce availability of long-term atmospheric data series has so far limited the analysis of low-frequency activity and intensity changes of cyclones over the North Atlantic and Europe. A novel reanalysis product, the Twentieth Century Reanalysis (20CR; Compo et al., 2011), spanning 1871 to present, offers potentially a very valuable resource for the analysis of the decadal-scale variability of cyclones over the North Atlantic sector and Europe. In the 20CR, only observations of synoptic surface pressure were assimilated. Monthly sea surface temperature and sea ice distributions served as boundary conditions. An Ensemble Kalman Filter assimilation technique was applied. "First guess" fields were obtained from an ensemble (with 56 members) of short-range numerical weather prediction forecasts. We apply the cyclone identification algorithm of Wernli and Schwierz (2006) to this data set, i.e. to each individual ensemble member. This enables us to give an uncertainty estimation of our findings. We find that 20CR shows a temporally relatively homogeneous representation of cyclone activity over Europe and great parts of the North Atlantic. Pronounced decadal-scale variability is found both in the frequency and intensity of cyclones over the North Atlantic and Europe. The low-frequency variability is consistently represented in all ensemble members. Our analyses indicate that in the past approximately 140 years the variability of cyclone activity and intensity over the North Atlantic and Europe can principally be associated with the North Atlantic Oscillation and secondary with a pattern similar to the East Atlantic pattern. Regionally however, the correlation between cyclone activity and these dominant modes of variability changes over time. Compo, G. P., J. S. Whitaker, P. D. Sardeshmukh, N. Matsui, R. J. Allan, X. Yin, B. E. Gleason, R. S. Vose, G. Rutledge, P. Bessemoulin, S. Brönnimann, M. Brunet, R. I. Crouthamel, A. N. Grant, P. Y. Groisman, P. D. Jones, M. C

  2. Formation and dynamics of Skyrmions in B20-type chiral magnets (United States)

    Kanazawa, Naoya


    was done in collaboration with X. Z. Yu, Y. Onose, J. H. Park, J. H. Han, N. Nagaosa, K. Kimoto, W. Z. Zhang, S. Ishiwata, Y. Matsui, T. Arima, D. Okuyama, K. Ohoyama, S. Wakimoto, K. Kakurai, A. Tsukazaki, M. Ichikawa, Y. Li, Y. Shiomi, K. Shibata, D. Inosov, J. H. Kim, J. White, N. Egetenmeyer, J. Gavilano, B. Keimer, and Y. Tokura.

  3. Indirect effect of changing aerosol concentrations on methane and ozone radiative forcing (United States)

    Rowlinson, Matthew; Rap, Alexandru; Arnold, Steve; Forster, Piers; Chipperfield, Martyn


    % decreases atmospheric sulpate concentrations by 44% after 2 years, while increasing global OH concentrations by 0.9%. CH4 lifetime is reduced by approximately 50 days as a result, leading to a decrease in CH4 burden of 38ppb. NOx is anticipated to have a similar but much larger effect (Matsui and Koike 2016). The Edwards and Slingo offline radiation model is also used to calculate changes to direct and indirect aerosol forcing. Presented here is the net RF change following 50% emission decrease of each aerosol or precursors, accounting for the direct and indirect aerosol effect as well as indirect effects via oxidation chemistry on the RF due to CH4 and tropospheric O3.

  4. The dexmedetomidine concentration required after remifentanil anesthesia is three-fold higher than that after fentanyl anesthesia or that for general sedation in the ICU

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    Kunisawa T


    Full Text Available Takayuki Kunisawa,1 Kazuhiro Fujimoto,2 Atsushi Kurosawa,2 Michio Nagashima,2 Koji Matsui,2 Dai Hayashi,2 Kunihiko Yamamoto,2 Yuya Goto,2 Hiroaki Akutsu,3 Hiroshi Iwasaki21Surgical Operation Department, Asahikawa Medical University Hospital, 2Department of Anesthesiology and Critical Care Medicine, 3Central Laboratory for Research and Education, Asahikawa Medical University, Asahikawa, Hokkaido, JapanPurpose: The general dexmedetomidine (DEX concentration required for sedation of intensive care unit patients is considered to be approximately 0.7 ng/mL. However, higher DEX concentrations are considered to be required for sedation and/or pain management after major surgery using remifentanil. We determined the DEX concentration required after major surgery by using a target-controlled infusion (TCI system for DEX.Methods: Fourteen patients undergoing surgery for abdominal aortic aneurysms (AAA were randomly, double-blindly assigned to two groups and underwent fentanyl- or remifentanil-based anesthetic management. DEX TCI was started at the time of closing the peritoneum and continued for 12 hours after stopping propofol administration (M0; DEX TCI was adjusted according to the sedation score and complaints of pain. The doses and concentrations of all anesthetics and postoperative conditions were investigated.Results: Throughout the observation period, the predicted plasma concentration of DEX in the fentanyl group was stable at approximately 0.7 ng/mL. In contrast, the predicted plasma concentration of DEX in the remifentanil group rapidly increased and stabilized at approximately 2 ng/mL. The actual DEX concentration at 540 minutes after M0 showed a similar trend (0.54±0.14 [fentanyl] versus 1.57±0.39 ng/mL [remifentanil]. In the remifentanil group, the dopamine dose required and the duration of intubation decreased, and urine output increased; however, no other outcomes improved.Conclusion: The DEX concentration required after AAA surgery with

  5. Reconstructing Links between AMOC and Surface Temperature Variability in the North Atlantic (United States)

    Borchert, Leonard; Fischer, Matthias; Müller, Wolfgang; Baehr, Johanna


    Recent studies found an impact of the Atlantic Meridional Overturning Circulation (AMOC) through sea surface temperatures (SSTs) and ocean-atmosphere surface heat fluxes (SHFs) on North Atlantic (NA) climate on interannual time scales. Since fluctuations in SSTs and SHFs as well as AMOC and oceanic heat transport (OHT) are highly model dependent and cannot be assumed to be independent of the mean state of the model in use. By using the Max Planck Institute Ocean Model (MPIOM) forced with the Twentieth Century Reanalysis (20CR, Compo et al (2011)), we confirm earlier studies and reconstruct for the governing period 1871-2010, that cold SSTs emerge in the Gulf Stream region and warm SSTs emerge in the NA Subpolar Gyre after strong AMOC anomalies at 50° N. The MPIOM in use has an average 1.5° horizontal resolution and 40 vertical non-equidistant depth levels. The model is forced by fluxes of heat, momentum, and freshwater at the air sea boundary through bulk formulas as described in Müller et al (2014). A positive density anomaly in the NA (= higher salinity / lower temperatures) is followed by an intensification of the AMOC and subsequently OHT. The proposed mechanism is examined in more detail studying correlations between AMOC, OHT, SSTs, and SHFs, as well as composite means of SSTs and SHFs in the Atlantic focusing on particularly strong and weak AMOC and OHT states at 50° N. High SSTs are shown to mostly appear simultaneously with upward SHFs and vice versa. The characteristic AMOC anomaly pattern appears in both correlation analysis and composite mean analysis over strong AMOC states after 2-6 years, and seems to occur favorably in winter (DJF). We further demonstrate that a similar, stronger pattern arises from OHT anomalies on similar time scales. Literature: Compo, GP, JS Whitaker, PD Sardeshmukh, N Matsui, RJ Allan, X Yin, BE Gleason, RS Vose, G Rutledge, P Bessemoulin, S Brönnimann, M Brunet, RJ Crouthamel, AN Grant, PY Groisman, PD Jones, MC Kruk, AC

  6. Paradoxical association between body mass index and in-hospital mortality in elderly patients with chronic obstructive pulmonary disease in Japan

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    Yamauchi Y


    Full Text Available Yasuhiro Yamauchi,1,2 Wakae Hasegawa,1 Hideo Yasunaga,3 Mitsuhiro Sunohara,1 Taisuke Jo,1,2 Kazutaka Takami,1 Hiroki Matsui,3 Kiyohide Fushimi,4 Takahide Nagase1 1Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 2Division for Health Service Promotion, The University of Tokyo, Tokyo, Japan; 3Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan; 4Department of Health Policy and Informatics, Tokyo Medical and Dental University, Graduate School of Medicine, Tokyo, Japan Background and objective: The prevalence and mortality of chronic obstructive pulmonary disease (COPD in elderly patients are increasing worldwide. Low body mass index (BMI is a well-known prognostic factor for COPD. However, the obesity paradox in elderly patients with COPD has not been well elucidated. We investigated the association between BMI and in-hospital mortality in elderly COPD patients. Methods: Using the Diagnosis Procedure Combination database in Japan, we retrospectively collected data for elderly patients (>65 years with COPD who were hospitalized between July 2010 and March 2013. We performed multivariable logistic regression analysis to compare all-cause in-hospital mortality between patients with BMI of <18.5 kg/m2 (underweight, 18.5–22.9 kg/m2 (low–normal weight, 23.0–24.9 kg/m2 (high–normal weight, 25.0–29.9 kg/m2 (overweight, and ≥30.0 kg/m2 (obesity with adjustment for patient backgrounds. Results: In all, 263,940 eligible patients were identified. In-hospital mortality was 14.3%, 7.3%, 4.9%, 4.3%, and 4.4%, respectively, in underweight, low–normal weight, high–normal weight, overweight, and obese patients. Underweight patients had a significantly higher mortality than low–normal weight patients (odds ratio [OR]: 1.55, 95% confidence interval [CI]: 1.48–1.63, whereas lower mortality was associated with high

  7. E2f1-deficient NOD/SCID mice have dry mouth due to a change of acinar/duct structure and the down-regulation of AQP5 in the salivary gland. (United States)

    Satoh, Keitaro; Narita, Takanori; Matsuki-Fukushima, Miwako; Okabayashi, Ken; Ito, Tatsuro; Senpuku, Hidenobu; Sugiya, Hiroshi


    Non-obese diabetic (NOD) mice have been used as a model for dry mouth. NOD mice lacking the gene encoding E2f1, a transcription factor, develop hyposalivation more rapidly progressively than control NOD mice. However, the model mice are associated with an underlying disease such as diabetes. We have now established E2f1-deficient NOD/severe combined immunodeficiency disease (NOD/SCID.E2f1(-/-)) mice to avoid the development of diabetes (Matsui-Inohara et al., Exp Biol Med (Maywood) 234(12):1525-1536, 2009). In this study, we investigated the pathophysiological features of dry mouth using NOD/SCID.E2f1(-/-) mice. In NOD/SCID.E2f1(-/-) mice, the volume of secreted saliva stimulated with pilocarpine is about one third that of control NOD/SCID mice. In behavioral analysis, NOD/SCID.E2f1(-/-) mice drank plenty of water when they ate dry food, and the frequency and time of water intake were almost double compared with control NOD/SCID mice. Histological analysis of submandibular glands with hematoxylin-eosin stain revealed that NOD/SCID.E2f1(-/-) mice have more ducts than NOD/SCID mice. In western blot analysis, the expression of aquaporin 5 (AQP5), a marker of acinar cells, in parotid and in submandibular glands of NOD/SCID.E2f1(-/-) mice was lower than in NOD/SCID mice. Immunohistochemical analysis of parotid and submandibular acini revealed that the localization of AQP5 in NOD/SCID.E2f1(-/-) mice differs from that in NOD/SCID mice; AQP5 was leaky and diffusively localized from the apical membrane to the cytosol in NOD/SCID.E2f1(-/-) mice. The ubiquitination of AQP5 was detected in submandibular glands of NOD/SCID.E2f1(-/-) mice. These findings suggest that the change of acinar/duct structure and the down-regulation of AQP5 in the salivary gland cause the pathogenesis of hyposalivation in NOD/SCID.E2f1(-/-) mice.

  8. Effect of outpatient therapy with inhaled corticosteroids on decreasing in-hospital mortality from pneumonia in patients with COPD

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    Yamauchi Y


    Full Text Available Yasuhiro Yamauchi,1 Hideo Yasunaga,2 Wakae Hasegawa,1 Yukiyo Sakamoto,1 Hideyuki Takeshima,1 Taisuke Jo,1,3 Hiroki Matsui,2 Kiyohide Fushimi,4 Takahide Nagase1 1Department of Respiratory Medicine, Graduate School of Medicine, 2Department of Clinical Epidemiology and Health Economics, School of Public Health, 3Division for Health Service Promotion, The University of Tokyo, 4Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan Background and objectives: Inhaled corticosteroids (ICS and long-acting inhaled bronchodilators (IBD are beneficial for the management of COPD. Although ICS has been reported to increase the risk of pneumonia in patients with COPD, it remains controversial whether it influences mortality. Using a Japanese national database, we examined the association between preadmission ICS therapy and in-hospital mortality from pneumonia in patients with COPD. Methods: We retrospectively collected data from 1,165 hospitals in Japan on patients with COPD who received outpatient inhalation therapy and were admitted with pneumonia. Patients were categorized into those who received ICS with IBD and those who received IBD alone. We performed multivariate logistic regression analysis to examine the association between outpatient ICS therapy and in-hospital mortality, adjusting for the patients’ backgrounds. Results: Of the 7,033 eligible patients, the IBD alone group (n=3,331 was more likely to be older, have lower body mass index, poorer general conditions, and more severe pneumonia than the ICS with IBD group (n=3,702. In-hospital mortality was 13.2% and 8.1% in the IBD alone and the ICS with IBD groups, respectively. After adjustment for patients’ backgrounds, the ICS with IBD group had significantly lower mortality than the IBD alone group (adjusted odds ratio, 0.80; 95% confidence interval, 0.68–0.94. Higher mortality was associated with older age, being male


    Directory of Open Access Journals (Sweden)

    Jorge Perdomo


    Full Text Available The sports scheduling problem has been center of attention in the Operational Research community due to their variety of models, and computational complexity of solutions (see for example Ribeiro (2010. In a Round Robin tournament, the schedule is proposed by assigning a “home" or “away" labels to a preestablished itinerary, in a such way that the total distance traveled by the teams during the tournament is minimized. In terms of operation research, the problem is modeled as a binary quadratic programming problem with linear constraints. In Suzuka y cols. (2005 the problem is treated as a MIN-RES-CUT. In this work we study the structure of the home-away assignment problem, and propose a simplification of the combinatorial formulation. We solve exactly small instances of the problem with an exhaustive search, and also approximately solve larger instances with a random search. // RESUMEN El problema de elaboración de calendarios deportivos ha centrado la atención de la comunidad de investigación de operaciones por la variedad de modelos y la complejidad computacional de las soluciones (ver por ejemplo Ribeiro (2010. En torneos tipo Round Robin de ida y vuelta el calendario se propone asignando la etiqueta de local o visitante a cada equipo, en un itinerario preestablecido de manera que se minimice el recorrido total de los equipos durante el torneo. En términos de investigación de operaciones lo modelamos como un problema de optimización cuadrática binaria con restricciones lineales. Suzuka, Miyashiro, Yoshise, y Matsui (2005 lo tratan como uno de encontrar el corte mínimo con restricciones (Min-Res-Cut en un grafo no dirigido, proporcionando una formulación de optimización combinatoria. En el presente trabajo estudiamos la estructura del problema de asignación local-visitante, y proponemos una simplificación de la formulación de optimización combinatoria. Resolvemos de forma exacta con una búsqueda exhaustiva instancias peque

  10. Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential

    Directory of Open Access Journals (Sweden)

    Akinaga Sonoda


    Full Text Available Akinaga Sonoda1, Norihisa Nitta1, Ayumi Nitta-Seko1, Shinich Ohta1, Shigeyuki Takamatsu2, Yoshio Ikehata3, Isamu Nagano3, Jun-ichiro Jo4, Yasuhiko Tabata4, Masashi Takahashi1, Osamu Matsui3, Kiyoshi Murata11Department of Radiology, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga, 520-2192, Japan; 2Department of Radiology, Graduate School of Medical Science, Kanazawa University, Takara-machi 13-1, Kanazawa Ishikawa, 920-8641, Japan; 3Department of Natural Science and Technology, Graduate School of Engineering, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan; 4Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Shogoin kawara-machi 53, Sakyo-ku 606-8507, Kyoto, JapanAbstract: We developed a dextran-magnetite conjugated cisplatin (DM-Cis complex for use in thermal ablation and as a chemotherapeutic drug. To produce DM-Cis we reacted Cis with 1 mL DM (56 mg/mL iron. The temperature rise of DM-Cis was measured in vitro and in vivo under a portable induction-heating (IH device. Platinum desorption from DM-Cis over 24 hours was measured in bovine serum. In in vivo accumulation and magnet and exothermic experiments we used four rat groups. In group 1 we delivered DM-Cis intraperitoneally (ip and placed magnets subcutaneously (sc. In group 2 we injected saline (ip and placed magnets (sc. In group 3 we injected DM-Cis (ip and placed a sc incision (sham. The control (group 4 received an ip injection of saline. Rectus abdominis muscle tissue was stained with hematoxylin-eosin and iron-stained tissue areas (µm2 were calculated. The maximum platinum concentration in DM-Cis was approximately 105.6 µg/mL. Over 24 hours, 33.48% of platinum from DM-Cis was released. There was a significant difference (P < 0.05 in the iron-stained area between group 1 and the other groups. The temperature in muscle tissue registered a maximum of 56°C after about 4 min. DM-Cis may represent a

  11. Mortality associated with bone fractures in COPD patients

    Directory of Open Access Journals (Sweden)

    Yamauchi Y


    Full Text Available Yasuhiro Yamauchi,1 Hideo Yasunaga,2 Yukiyo Sakamoto,1 Wakae Hasegawa,1 Hideyuki Takeshima,1 Hirokazu Urushiyama,1 Taisuke Jo,1,3 Hiroki Matsui,2 Kiyohide Fushimi,4 Takahide Nagase1 1Department of Respiratory Medicine, Graduate School of Medicine, 2Department of Clinical Epidemiology and Health Economics, School of Public Health, 3Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, 4Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan Background and objective: COPD is well known to frequently coexist with osteoporosis. Bone fractures often occur and may affect mortality in COPD patients. However, in-hospital mortality related to bone fractures in COPD patients has been poorly studied. This retrospective study investigated in-hospital mortality of COPD patients with bone fractures using a national inpatient database in Japan.Methods: Data of COPD patients admitted with bone fractures, including hip, vertebra, shoulder, and forearm fractures to 1,165 hospitals in Japan between July 2010 and March 2013, were extracted from the Diagnosis Procedure Combination database. The clinical characteristics and mortalities of the patients were determined. Multivariable logistic regression analysis was also performed to determine the factors associated with in-hospital mortality of COPD patients with hip fractures.Results: Among 5,975 eligible patients, those with hip fractures (n=4,059 were older, had lower body mass index (BMI, and had poorer general condition than those with vertebral (n=1,477, shoulder (n=281, or forearm (n=158 fractures. In-hospital mortality was 7.4%, 5.2%, 3.9%, and 1.3%, respectively. Among the hip fracture group, surgical treatment was significantly associated with lower mortality (adjusted odds ratio, 0.43; 95% confidence interval, 0.32–0.56 after adjustment for patient backgrounds. Higher in-hospital mortality was

  12. Quantitative Mapping of Precursory Seismic Quiescence Before Large Aftershocks (United States)

    Neukomm, S.; Wiemer, S.; Giardini, D.


    A relative decrease of aftershock activity before the occurrence of large aftershocks to M6+ mainshocks is one of only few earthquake precursors accepted for the IASPEI preliminary list of significant earthquake precursors. If one considers earthquake rate to be dependent on stressing rate, aftershocks sequences offer in fact an ideal environment to detect precursory quiescence before large earthquakes: The numerous aftershocks allow a much higher spatial and temporal resolution of transients in seismicity than possible with the average background rate of micro-earthquakes. Past studies of precursory quiescence before larger aftershocks, however, have largely been based on bulk value. The aim of this study is to map the temporal and spatial variability of activity rate within several rich aftershock sequences, and, possibly, exploit the results for improving real time probabilistic aftershock hazard assessment. We introduce a new algorithm based on fitting the modified Omori law to the aftershock sequences. At arbitrarily chosen grid points, the Omori parameters of the sub-samples containing all aftershock within 5 or 10 km of the node are estimated at time t. We calculate the number of aftershocks N +/- dN in the time interval t + dt using the relevant four Omori parameters (p, c and k) parameters and their corresponding standard deviations estimated using a bootstrap analysis. The difference between the forecasted and the observed number of aftershocks, normalized by the standard deviation of the forecast, is our estimator of rate change. The algorithm is tested on synthetic aftershock sequences containing artificial quiescences in order to calibrate the free parameters for optimal detection of precursory quiescence. We then perform our spatial and temporal mapping for several prominent Californian and Japanese aftershock sequences (Landers, Hector Mine, Northridge, Loma Prieta, Kobe, Western Tottori and Hokkaido). Preliminary results suggest that we cannot

  13. Effect of repeated Waon therapy on exercise tolerance and pulmonary function in patients with chronic obstructive pulmonary disease: a pilot controlled clinical trial

    Directory of Open Access Journals (Sweden)

    Kikuchi H


    Full Text Available Hiroshi Kikuchi,1,2 Nobuyoshi Shiozawa,1 Shingo Takata,1 Kozo Ashida,1 Fumihiro Mitsunobu11Division of Medicine, Misasa Medical Center, Okayama University Hospital, Misasa, Tottori, Japan; 2Division of Internal Medicine, Takamatsu Hospital KKR, Takamatsu, JapanPurpose: Controlled clinical trials evaluating the efficacy of repeated Waon therapy for patients with chronic obstructive pulmonary disease (COPD have yet to be conducted. The purpose of the present study was to evaluate whether repeated Waon therapy exhibits an adjuvant effect on conventional therapy for COPD patients.Patients and methods: This prospective trial comprised 20 consecutive COPD patients who satisfied the criteria of the Global initiative for chronic Obstructive Lung Disease (GOLD guidelines, stages 1–4. They were assigned to either a Waon or control group. The patients in the Waon group received both repeated Waon therapy and conventional therapy, including medications, such as long-acting inhaled β2 agonists, long-acting anticholinergics and xanthine derivatives, and pulmonary rehabilitation. The Waon therapy consisted of sitting in a 60°C sauna room for 15 minutes, followed by 30 minutes of being warmed with blankets once a day, 5 days a week, for a total of 20 times. The patients in the control group received only conventional therapy. Pulmonary function and the 6-minute walk test were assessed before and at 4 weeks after the program.Results: The change in vital capacity (0.30 ± 0.4 L and in peak expiratory flow (0.48 ± 0.79 L/s in the Waon group was larger than the change in the vital capacity (0.02 ± 0.21 L (P=0.077 and peak expiratory flow (−0.11 ± 0.72 L/s (P=0.095 in the control group. The change in forced expiratory flow after 50% of expired forced vital capacity in the Waon group, 0.08 (0.01–0.212 L/s, was larger than that in the control group, −0.01 (−0.075–0.04 L/s (P=0.019. Significant differences were not observed in the change in any

  14. Survival Analysis of Patients with Interval Cancer Undergoing Gastric Cancer Screening by Endoscopy (United States)

    Hamashima, Chisato; Shabana, Michiko; Okamoto, Mikizo; Osaki, Yoneatsu; Kishimoto, Takuji


    Aims Interval cancer is a key factor that influences the effectiveness of a cancer screening program. To evaluate the impact of interval cancer on the effectiveness of endoscopic screening, the survival rates of patients with interval cancer were analyzed. Methods We performed gastric cancer-specific and all-causes survival analyses of patients with screen-detected cancer and patients with interval cancer in the endoscopic screening group and radiographic screening group using the Kaplan-Meier method. Since the screening interval was 1 year, interval cancer was defined as gastric cancer detected within 1 year after a negative result. A Cox proportional hazards model was used to investigate the risk factors associated with gastric cancer-specific and all-causes death. Results A total of 1,493 gastric cancer patients (endoscopic screening group: n = 347; radiographic screening group: n = 166; outpatient group: n = 980) were identified from the Tottori Cancer Registry from 2001 to 2008. The gastric cancer-specific survival rates were higher in the endoscopic screening group than in the radiographic screening group and the outpatients group. In the endoscopic screening group, the gastric cancer-specific survival rate of the patients with screen-detected cancer and the patients with interval cancer were nearly equal (P = 0.869). In the radiographic screening group, the gastric cancer-specific survival rate of the patients with screen-detected cancer was higher than that of the patients with interval cancer (P = 0.009). For gastric cancer-specific death, the hazard ratio of interval cancer in the endoscopic screening group was 0.216 for gastric cancer death (95%CI: 0.054-0.868) compared with the outpatient group. Conclusion The survival rate and the risk of gastric cancer death among the patients with screen-detected cancer and patients with interval cancer were not significantly different in the annual endoscopic screening. These results suggest the potential of

  15. Use of ARM observations and numerical models to determine radiative and latent heating profiles of mesoscale convective systems for general circulation models

    Energy Technology Data Exchange (ETDEWEB)

    Tao, Wei-Kuo; Houze, Robert, A., Jr.; Zeng, Xiping


    submitted in September 2012. The major highlights are as follows: a. The results indicate that NU-WRF model could capture observed diurnal variation of rainfall (composite not individual); b. NU-WRF model could simulate two different types (propagating and local type) of the diurnal variation of rainfall; c. NU-WRF model simulation show very good agreement with observation in terms of precipitation pattern (linear MCS), radar reflectivity (a second low peak shallow convection); d. NU-WRF model simulation indicates that the cool-pool dynamic is the main physical process for MCS propagation speed; e. Surface heat fluxes (including land surface model and initial surface condition) do not play a major role in phase of diurnal variation (change rainfall amount slightly); f. Terrain effect is important for initial stage of MCS (rainfall is increased and close to observation by increasing the terrain height that is also close to observed); g. Diurnal variation of radiation is not important for the simulated variation of rainfall. Publications: Zeng, X., W.-K. Tao, S. Powell, R. Houze, Jr., P. Ciesielski, N. Guy, H. Pierce and T. Matsui, 2012: A comparison of the water budgets between clouds from AMMA and TWP-ICE. J. Atmos. Sci., 70, 487-503. Powell, S. W., R. A. Houze, Jr., A. Kumar, and S. A. McFarlane, 2012: Comparison of simulated and observed continental tropical anvil clouds and their radiative heating profiles. J. Atmos. Sci., 69, 2662-2681. Zeng, X., W.-K. Tao, T. Matsui, S. Xie, S. Lang, M. Zhang, D. Starr, and X. Li, 2011: Estimating the Ice Crystal Enhancement Factor in the Tropics. J. Atmos. Sci., 68, 1424-1434. Conferences: Zeng, X., W.-K. Tao, S. Powell, R. Houze, Jr., P. Ciesielski, N. Guy, H. Pierce and T. Matsui, 2012: Comparison of water budget between AMMA and TWP-ICE clouds. The 3rd Annual ASR Science Team Meeting. Arlington, Virginia, Mar. 12-16, 2012. Zeng, X., W.-K. Tao, S. Powell, R. A. Houze Jr., and P. Ciesielski, 2011: Comparing the water budgets between

  16. Effects of solar dimming and brightening on the terrestrial carbon sink (United States)

    Mercado, L.; Bellouin, N.; Sitch, S.; Boucher, O.; Huntingford, C.; Wild, M.; Cox, P. M.


    photosynthesis for climate model applications. Tellus Series B-Chemical and Physical Meteorology, 59, 553-565. Niyogi D., Chang H.I., Saxena V.K., Holt T., Alapaty K., Booker F., Chen F., Davis K.J., Holben B., Matsui T., Meyers T., Oechel W.C., Pielke R.A., Wells R., Wilson K. & Xue Y.K. (2004) Direct observations of the effects of aerosol loading on net ecosystem CO2 exchanges over different landscapes. Geophysical Research Letters, 31. Oliveira P.H.F., Artaxo P., Pires C., De Lucca S., Procopio A., Holben B., Schafer J., Cardoso L.F., Wofsy S.C. & Rocha H.R. (2007) The effects of biomass burning aerosols and clouds on the CO2 flux in Amazonia. Tellus Series B-Chemical and Physical Meteorology, 59, 338-349. Roderick M.L., Farquhar G.D., Berry S.L. & Noble I.R. (2001) On the direct effect of clouds and atmospheric particles on the productivity and structure of vegetation. Oecologia, 129, 21-30. Stanhill G. & Cohen S. (2001) Global dimming: a review of the evidence for a widespread and significant reduction in global radiation with discussion of its probable causes and possible agricultural consequences. 107, 255-278. Wild M., Gilgen H., Roesch A., Ohmura A., Long C.N., Dutton E.G., Forgan B., Kallis A., Russak V. & Tsvetkov A. (2005) From dimming to brightening: Decadal changes in solar radiation at Earth's surface. Science, 308, 847-850.

  17. Downscaling 20th century flooding events in complex terrain (Switzerland) using the WRF regional climate model (United States)

    Heikkilä, Ulla; Gómez Navarro, Juan Jose; Franke, Jörg; Brönnimann, Stefan; Cattin, Réne


    validate the model performance during a larger number of events. Compo, G. P., J. S. Whitaker, P. D. Sardeshmukh, N. Matsui, R. J. Allan, X. Yin,B. E. Gleason, R. S. Vose, G. Rutledge, P. Bessemoulin, S. Bronnimann, M. Brunet, R. I. Crouthamel, A. N. Grant, P. Y. Groisman, P. D. Jones, M. C. Kruk, A. C. Kruger, G. J. Marshall, M. Maugeri, H. Y. Mok, O. Nordli, T. F. Ross, R. M. Trigo, X. L. Wang, S. D. Woodruff, S. J. Worley, 2011: The Twentieth Century Reanalysis Project. Quarterly J. Roy. Met. Soc., 137, 1-28, DOI: 10.1002/qj.776. Hohenegger, C., Walser, A., Langhans, H. and Schär, C., 2008, Cloud-resolving ensemble simulations of the August 2005 Alpine flood, Q. J. R. Meteorol. Soc. 2008, DOI: 10.1002/qj.252 Stucki, P., Rickli, R., Brönnimann, S., Martius, O., Wanner, H., Grebner, D. and Luterbacher, J., 2012, Weather patterns and hydro-climatological precursors of extreme floods in Switzerland since 1868, Meteorologische Zeitschrift, Vol. 21, No. 6, 531-550.

  18. Atmospheric circulation leading to record breaking precipitation and floods in southern Iberia in December 1876 (United States)

    Trigo, R. M.; Varino, F.; Vaquero, J.; Valente, M. A.


    exception of events in February 2008 in the Lisbon precipitation (Fragoso et al., 2010) and October 1944 in Évora (in both cases for daily precipitation only). Compo G. P., Whitaker J.S., Sardeshmukh P.D., Matsui N., Allan R.J., Yin X., Gleason E., J.r., Vose R. S., Rutledge G., Bessemoulin P., Brönnimann S., Brunet M., Crouthamel R.I., Grant A.N., Groisman P. Y., Jones P. D., Kruk M. C., Kruger A.C., Marshall G. J., Maugeri M., Mok H. Y., Nordlki, Ross T.F., Trigo R. M., Wang X. L., Woodruff S. D., Worley S. J. (2011). The Twentieth Century Reanalysis Project. Quarterly Journal of the Royal Meteorological Society, 137(654), 1-28. doi:10.1002/qj.776 Fragoso, M., Trigo, R. M., Zêzere, J. L., & Valente, M. A. (2010). The exceptional rainfall event in Lisbon on 18 February 2008. Weather, 65(2), 31-35. doi:10.1002/wea.513

  19. PREFACE: 7th International Conference on Applications of Physics in Financial Analysis (United States)

    Takayasu, M.; Watanabe, T.; Ikeda, Y.; Takayasu, H.


    become interested in such datasets, conducting empirical investigations about various aspects of economic activities. Specifically, they have searched for regularities and 'laws' akin to the ones in natural science, successfully producing fascinating results, as shown in the papers contained in this volume. Each paper submitted for publication in this volume has gone through the refereeing process, and has been revised on the basis of comments and discussion at the conference as well as comments from the anonymous referees. Finally, 19 papers were accepted for publication. The editors are very grateful to the colleagues involved in the refereeing process for their rapid and careful reviewing of the papers. We thank Takayuki Mizuno, Koji Sakai, Hiwon Yoon and Hiroki Matsui for their support for the conference. We appreciate the administrative assistance provided by Yayoi Hatano of Hitotsubashi University, and Masahiko Ozaki, Masato Yamada and Tomoko Kase of RIETI. We are most grateful to the authors for their contributions, as well as to the participants, all of whom made this conference stimulating and enjoyable. Misako Takayasu Tokyo Institute of Technology, Japan Tsutomu Watanabe Hitotsubashi University, Japan RIETI, Japan Yuichi Ikeda Hitachi Research Laboratory, Hitachi Ltd, Japan Hideki Takayasu Sony Computer Science Laboratories, Inc, Japan

  20. Methylmalonic Acidemia: Diagnosis and Neuroimaging Findings of This Neurometabolic Disorder (An Iranian Pediatric Case Series

    Directory of Open Access Journals (Sweden)

    Parvaneh KARIMZADEH


    , Melhem ER, Barker PB. Multi-slice proton MR spectroscopy and diffusion-weighted imaging in methylmalonic acidemia: report of two cases and review of the literature. AJNR Am J Neuroradiol 2001;22(5:831-3.2. Mahoney MJ, Bick D. Recent advances in the inherited methylmalonic acidemias. Acta Paediatr Scand1987;76(5:689-96.3. Radmanesh A, Zaman T, Ghanaati H, Molaei S, Robertson RL, ZamaniAA. Methylmalonic acidemia: brain imaging findings in 52 children and a review of the literature.Pediatr Radiol 2008 Oct;38(10:1054-61.4. Cantani A. [Methylmalonic acidemia: classification, diagnosis and therapy]. KlinPadiatr 1983;195(6:388-93.5. Avery ME, First LR, Pediatric Medicine, 2nd ed. Williams & Wilkins, Waverly Company; 1994. p.1075.6. Matsui SM, Mahoney MJ, Resenberg LE. The natural history of the inherited methylmalonic acidemias. N Engl J Med 1983;308(15:857-61.7. Holliday MA, Barrat M, Arner ED. Pediatric Nephrology, 3rd ed. William and Wilkins 1994; p. 890.8. Soda H, Yoshida I, Aramaki S, Kuriya N, Aoki K, Inokuchi T, et al. Renal handling of methylmalonic acid in a uraemic patient with vitamin B12 unresponsive methylmalonica cidaemia. J Inherit Metab Dis 1996;19(1:90-1.9. Imen M, Hanene B, Ichraf K, Aida R, Ilhem T, Naziha K, et al. Methylmalonic acidemia and hyperglycemia: an unusual association. Brain Dev 2012;34(2:113-4.10. Ma X, Zhang Y, Yang Y, Liu X, Yang Z, Bao X, et al. Epilepsy in children with methylmalonic acidemia: electroclinical features and prognosis. Brain Dev 2011;33(9:790-5.11. Brismar J, Ozand PT. CT and MR of the brain in disorders of the propionate and methylmalonatemetabolism. AJNR Am J Neuroradiol 1994;15(8:1459-73.12. Nicolaides P, Leonard J, Surtees R. Neurological outcome of methylmalonic acidaemia. Arch Dis Child 1998;78:508-12. 

  1. Impact of Changes in Diffuse Radiation on the Global Land Carbon Sink, 1901-2100 (United States)

    Mercado, L.; Bellouin, N.; Sitch, S.; Boucher, O.; Huntingford, C.; Wild, M.; Cox, P. M.


    .J., Holben B., Matsui T., Meyers T., Oechel W.C., Pielke R.A., Wells R., Wilson K. & Xue Y.K. (2004) Direct observations of the effects of aerosol loading on net ecosystem CO2 exchanges over different landscapes. Geophysical Research Letters, 31. Oliveira P.H.F., Artaxo P., Pires C., De Lucca S., Procopio A., Holben B., Schafer J., Cardoso L.F., Wofsy S.C. & Rocha H.R. (2007) The effects of biomass burning aerosols and clouds on the CO2 flux in Amazonia. Tellus Series B-Chemical and Physical Meteorology, 59, 338-349. Roderick M.L., Farquhar G.D., Berry S.L. & Noble I.R. (2001) On the direct effect of clouds and atmospheric particles on the productivity and structure of vegetation. Oecologia, 129, 21-30.

  2. Tsunami-induced boulder transport - combining physical experiments and numerical modelling (United States)

    Oetjen, Jan; Engel, Max; May, Simon Matthias; Schüttrumpf, Holger; Brueckner, Helmut; Prasad Pudasaini, Shiva


    since they have been largely neglected. In order to tackle these gaps, we develop a novel BTM in two steps. First, scaled physical experiments are performed that determine the exact hydrodynamic processes within a tsunami during boulder transportations. Furthermore, the experiments are the basis for calibrating the numerical BTM. The BTM is based on the numerical two-phase mass flow model of Pudasaini (2012) that employs an advanced and unified high-resolution computational tool for mixtures consisting of the solid and fluid components and their interactions. This allows for the motion of the boulder while interacting with the particle-laden tsunami on the inundated coastal plane as a function of the total fluid and solid stresses. Our approach leads to fundamentally new insights in to the essential physical processes in BTM. Goto, K., Chavanich, S. A., Imamura, F., Kunthasap, P., Matsui, T., Minoura, K., Sugawara, D. and Yanagisawa, H.: Distribution, origin and transport process of boulders deposited by the 2004 Indian Ocean tsunami at Pakarang Cape, Thailand. Sediment. Geol., 202, 821-837, 2007. Imamura, F., Goto, K. and Ohkubo, S.: A numerical model of the transport of a boulder by tsunami. J. Geophys. Res. Oceans, 113, C01008, 2008. Pudasaini, S. P.: A general two-phase debris flow model. J. Geophys. Res. Earth Surf., 117, F03010, 2012.

  3. Reassessing the impacts and the atmospheric circulation of the large storms over Portugal (United States)

    Varino, F.; Trigo, R. M.; Zêzere, J. L.


    level pressure fields. Additionally a number of other fields were computed and shown in common graphics, namely precipitation rate and CAPE, wind speed and wind divergence at 250 hPa and at 850 hPa geopotential height levels, air temperature at 850 hPa and geopotential height at 500h Pa and finally wind speed barbs and specific moisture content. Compo G. P., Whitaker J.S., Sardeshmukh P.D., Matsui N., Allan R.J., Yin X., Gleason E., J.r., Vose R. S., Rutledge G., Bessemoulin P., Brönnimann S., Brunet M., Crouthamel R.I., Grant A.N., Groisman P. Y., Jones P. D., Kruk M. C., Kruger A.C., Marshall G. J., Maugeri M., Mok H. Y., Nordlki, Ross T.F., Trigo R. M., Wang X. L., Woodruff S. D., Worley S. J. (2011). The Twentieth Century Reanalysis Project. Quarterly Journal of the Royal Meteorological Society, 137(654), 1-28. doi:10.1002/qj.776

  4. Investigation on the movements and the distributions of radon, thoron and their decay nuclides on the life circumstances

    Energy Technology Data Exchange (ETDEWEB)

    Morishima, Hiroshige; Koga, Taeko [Kinki Univ., Higashi-Osaka, Osaka (Japan). Atomic Energy Research Inst


    UNSCEAR (2000) reported that the effective doses due to the inhalation of radon and its decay nuclides account on average of the all world for about one-half of all natural sources of radiation. These have great influences on various forms as the sources of terrecial environmental {gamma} radiation and of radon on our life circumstances. Radon and thoron, which are natural gaseous radioactive nuclides released out of rocks and soil etc. are chemical inert and electrically uncharged, but they in the air can spontaneously decay to other metal atoms. And they made a wide fluctuation seasonally and spatially on the environment, but these are not uniformly. We have selected and observed on Misasa spa district, Tottori pref., Kawanishi-shi, Hyogo pref. and Masutomi spa, Yamanashi pref., for HBRA, and Higashi-osaka-shi, Osaka pref., for CA. We have carried out the study on the environmental movement and distribution of natural radioactive nuclides containing radon, thoron and their decay nuclides, and reported these results on following; (1) Radon measurements have been carried using a small pico-rad detector and many sampling points and Pilon scintillation-cell with 300 ml volume by grub sampling. Mean radon concentrations of get briefly for 24 hours are measured to be available on draw of the concentration distribution map. (2) We continued time cource variation of mean radon concentrations on same private house of Misasa spa district. Mean radon concentrations in air for 6 years were fluctuated 6.7-50 Bq/m{sup 3} and 23-170 Bq/m{sup 3} indoor. The mean concentrations on summer and rain season is low level at open-door situation and that on winter is high, as same as these on Kawanishi Hyogo pref.. It was shown that radon outdoor concentrations variation in time course almost have a similar tendency with indoor and the life situation of air ventilation and conditioning are more influenced than variation on area condition. (3) Radon concentrations on Masutomi spa

  5. Re-examination of the original questionnaire documents for the 1944 Tonankai, 1945 Mikawa, and 1946 Nanaki earthquakes (United States)

    Harada, Tomoya; Satake, Kenji; Furumura, Takashi


    With the object of estimating seismic intensity, the Earthquakes Research Institute (ERI) of the University of Tokyo performed questionnaire surveys for the significant (destructive or large/great) earthquakes from 1943 to 1988 (Kayano, 1990, BERI). In these surveys, Kawasumi (1943)'s 12-class seismic intensity scale similar to the Modified Mercalli scale (MM-scale) was used. Survey results for earthquakes after 1950 were well investigated and published (e.g. Kayano and Komaki, 1977, BERI; Kayano and Sato, 1975, BERI), but the survey results for earthquakes in the 1940s have not been published and original documents of the surveys was missing. Recently, the original sheets of the surveys for the five earthquakes in the 1940s with more than 1,000 casualties were discovered in the ERI warehouse, although they are incomplete (Tsumura et al, 2010). They are from the 1943 Tottori (M 7.2), 1944 Tonankai (M 7.9), 1945 Mikawa (M 6.8), 1946 Nankai (M 8.0), and 1948 Fukui (M 7.1) earthquakes. In this study, we examined original questionnaire and summary sheets for the 1944 Tonankai, 1945 Mikawa, and 1946 Nanaki earthquakes, and estimated the distributions of seismic intensity, various kinds of damage, and human behaviors in detail. Numbers of the survey points for the 1944, 1945, and 1946 event are 287, 145, and 1,014, respectively. The numbers for the 1944 and 1945 earthquakes are much fewer than that of the 1946 event, because they occurred during the last years of World War II. The 1944 seismic intensities in the prefectures near the source region (Aichi, Mie, Shizuoka, and Gifu Pref.) tend to be high. However, the 1944 intensities are also high and damage is serious at the Suwa Lake shore in Nagano Pref. which is about 240 km far from the source region because seismic waves are amplified dramatically in the thick sediment in the Suwa Basin. Seismic intensities of the 1945 Mikawa earthquake near the source region in Aichi Pref. were very high (X-XI). However, the

  6. The Relation Between Flase-Belief Understanding and the Using of Mental State Terms during Picture Talking for Preschoolers:A Short-Term Longitudinal Study%幼儿看图叙述中心理状态术语的使用与错误信念理解关系的短期跟踪研究

    Institute of Scientific and Technical Information of China (English)

    张长英; 桑标; 戴玉英; 刘蓓


    Numerous studies have shown that not only is children's language ability related to false-belief understanding,but also it appears to play an important role in the development of theory of mind(ToM).However,it remained unclear which aspect of language development contributes most to the development of ToM.Many researchers such as Moore et al.(1994) and de Matsui et al.(2006) argued that the mental state language of particular languages might be related to children's theory of mind development. This study explored the relationship between preschoolers' false-belief understanding and the using of mental state terms within a storytelling task.With 101 children aged 3-5 in the kindergarten as subjects,the study adopted a short-term longitudinal design that was administered twice at three-month intervals,so that children's mental slate discourse at both Time 1 and Time 2 could be related to falsebelief, which was assessed at Time 2.This study was designed to examine children's mental state discourse within a storytelling task,in which children were asked to generate responses to a series of photographs,and assess the relationship between false-belief understanding and the using of mental state terms with a set of false belief tasks,including unexpected transfer,unexpected content and appearance -reality task.The results showed that false-belief understanding and the using of mental state terms were very close to each other. During picture talking,the preschoolers used more desire and emotional terms than belief terms,and vocabulary types of the cognitive terms were less,mainly 'yao4' and 'xiang3'.Furthermore,with the general language ability and age under control,the first test still showed a remarkable correlation between children' emotional terms,belief terms and false-belief understanding in the same and even later period.But there was no evident correlation between the false belief task performance at Time1 and the mental state language at Time2. The results of this

  7. Seasonal and spatial contrasts of sedimentary organic carbon in floodplain lakes of the central Amazon basin. (United States)

    Sobrinho, Rodrigo; Kim, Jung-Hyun; Abril, Gwenaël; Zell, Claudia; Moreira-Turcq, Patricia; Mortillaro, Jean-Michel; Meziane, Tarik; Damsté, Jaap; Bernardes, Marcelo


    .d.C., Mertes, L., Richey, J.E., Devol, A.H., Forsberg, B.R.. Inland variability of carbon-nitrogen concentrations and d13C in Amazon floodplain (várzea) vegetation and sediment. Hydrol. Process. 17, 1419-1430 (2003). Victoria, R.L., Martinelli, L.A., Trivelin, P.C.O., Matsui, E., Forsberg, B.R., Richey, J.E., Devol, A.H.. The use of stable isotopes in studies of nutrient cycling: Carbon Isotope composition of Amazon varzea sediments. Biotropica 24, 240-249 (1992).

  8. Committees (United States)


    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  9. Study on the environmental movements and distributions of natural radioactive nuclides on the granite area (III)

    Energy Technology Data Exchange (ETDEWEB)

    Morishima, Hiroshige; Koga, Taeko [Kinki Univ., Atomic Energy Research Institute, Higashi-Osaka, Osaka (Japan)


    The natural radionuclides as K-40, uranium decay series and thorium decay series etc. are widely distributed on environment, but are not uniformly. These have influences various forms as the sources of terrecial environmental {gamma} radiation and of radon in to the human life environment and make wide fluctuation seasonal and spatially on the environment. The environmental radiation is higher than that of the other on the west Japan where generally consist rich of granite strata. We deeply appreciate in regard to natural radiation and would carry the studies on the movement and distribution of natural radioactive nuclides on high background radiation area consisted rich granite strata. We have selected and observed on Ikeda mineral spring district Ota-shi Shimane pref., Misasa spa district, Tohaku-gun, Tottori pref. on Chugoku area, Muro district Uda-gun, Hachibuse district, Nafa-shi Nara pref., and Arima spa district, Hyogo-pref., Kawanishi-shi, Hyogo pref. on Kinki area and Masutomi spa, Koma-gun, Yamanashi pref., for HBRA, and Higashi-osaka-shi, Osaka pref., for CA. We have carried out the study on the environmental movement and distribution of natural radioactive nuclides containing radon and decay nuclides, and reported these results on following; (1) Radon measurements have been carried using cup typed radon and thoron monitors which are easy handling in spite of need of long sampling period, pico-rad method by active charcoal sampling and Pilon scintillation-cell with 300 ml volume by grub sampling. Accumulated radon monitors have been used cellulose nitrate (LR-115 type II, Kodak Co.) as solid state track detector. Among these characteristics of radon monitors, though minimum detectable limit of cup method for 3 months sampling is higher than those by the other method, it is able to measure mean Rn-222 concentration for 3 months. Rn-222 concentration by pico-rad method is able to get briefly mean concentration for 24 hours, is small detector and many

  10. PREFACE: Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009) Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009) (United States)

    Tanaka, Isao; Hafner, Jürgen; Wimmer, Erich; Asahi, Ryoji


    . Lectures and poster presentations were thus solicited from leading international academic and industrial researchers. The large audience that attended responded to the high quality of the talks with pertinent questions and lively discussions. The third workshop, TMI2009, was held over three days from 11-13 November, 2009, at the Nagoya International Center, Nagoya, Japan. Invited talks were given by 23 speakers from 9 countries from both the academic and industry sectors. The speakers were Ryoji Asahi (Toyota Central R&D Labs, Japan), Tomas Bucko (University of Vienna, Austria), Gábor Csányi (University of Cambridge, UK), Alessandro De Vita (King's College London, UK), Bernard Delley (Paul Scherrer Institute, Switzerland), Christophe Domain (EDF, France), George Fitzgerald (Accelrys, USA), Takeo Fujiwara (University of Tokyo, Japan), Jürgen Hafner (University of Vienna, Austria), Masaya Ishida (Sumitomo Chemicals, Japan), Werner Janse Van Rensburg (Sasol Technology, South Africa), Masanori Kohyama (AIST, Japan), Takao Kotani (Tottori University, Japan), Georg Kresse (University of Vienna, Austria), Katsuyuki Matsunaga (Kyoto University, Japan), Stefan Müller (University of Erlangen-Nuremberg, Germany), Shin-ichiro Nakamura (Mitsubishi Chemicals, Japan), Fumiyasu Oba (Kyoto University, Japan), Tamio Oguchi (Hiroshima University, Japan), Pascal Raybaud (IFP, France), Isao Tanaka (Kyoto University/JFCC, Japan), Göran Wahnström (Chalmers University of Technology, Sweden), and Erich Wimmer (Materials Design Inc., USA). There were 40 poster presentations in total. The workshop was attended by approximately 120 participants with approximately 50 per cent from industry. The invited talks covered advances in ab initio solid-state calculations and their practical use in industry. Presentations outlining the progress made in treating large and complex systems, as well as more accurate and efficient calculation methods, were given from the theory side. Examples of the use of ab

  11. PREFACE: Nanosafe2010: International Conference on Safe Production and Use of Nanomaterials (United States)

    Sentein, Carole; Schuster, Frédéric; Tardif, François