Bulk locality and entanglement swapping in AdS/CFT

Energy Technology Data Exchange (ETDEWEB)

Kelly, William R. [Center for Quantum Mathematics and Physics (QMAP),Department of Physics, University of California,Davis, CA 95616 (United States)

2017-03-29

Localized bulk excitations in AdS/CFT are produced by operators which modify the pattern of entanglement in the boundary state. We show that simple models — consisting of entanglement swapping operators acting on a qubit system or a free field theory — capture qualitative features of gravitational backreaction and reproduce predictions of the Ryu-Takayanagi formula. These entanglement swapping operators naturally admit multiple representations associated with different degrees of freedom, thereby reproducing the code subspace structure emphasized by Almheiri, Dong, and Harlow. We also show that the boundary Reeh-Schlieder theorem implies that equivalence of certain operators on a code subspace necessarily breaks down when non-perturbative effects are taken into account (as is expected based on bulk arguments).

Holographic fluctuations and the principle of minimal complexity

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Chemissany, Wissam [Institut für Theoretische Physik, Leibniz Universität Hannover,Appelstr. 2, 30167 Hannover (Germany); Department of Mechanical Engineering, MIT,Cambridge MA 02139 (United States); Osborne, Tobias J. [Institut für Theoretische Physik, Leibniz Universität Hannover,Appelstr. 2, 30167 Hannover (Germany)

2016-12-14

We discuss, from a quantum information perspective, recent proposals of Maldacena, Ryu, Takayanagi, van Raamsdonk, Swingle, and Susskind that spacetime is an emergent property of the quantum entanglement of an associated boundary quantum system. We review the idea that the informational principle of minimal complexity determines a dual holographic bulk spacetime from a minimal quantum circuit U preparing a given boundary state from a trivial reference state. We describe how this idea may be extended to determine the relationship between the fluctuations of the bulk holographic geometry and the fluctuations of the boundary low-energy subspace. In this way we obtain, for every quantum system, an Einstein-like equation of motion for what might be interpreted as a bulk gravity theory dual to the boundary system.

Entanglement entropy in top-down models

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Jones, Peter A.R.; Taylor, Marika [Mathematical Sciences and STAG Research Centre, University of Southampton,Highfield, Southampton, SO17 1BJ (United Kingdom)

2016-08-26

We explore holographic entanglement entropy in ten-dimensional supergravity solutions. It has been proposed that entanglement entropy can be computed in such top-down models using minimal surfaces which asymptotically wrap the compact part of the geometry. We show explicitly in a wide range of examples that the holographic entanglement entropy thus computed agrees with the entanglement entropy computed using the Ryu-Takayanagi formula from the lower-dimensional Einstein metric obtained from reduction over the compact space. Our examples include not only consistent truncations but also cases in which no consistent truncation exists and Kaluza-Klein holography is used to identify the lower-dimensional Einstein metric. We then give a general proof, based on the Lewkowycz-Maldacena approach, of the top-down entanglement entropy formula.

Entanglement entropy in top-down models

International Nuclear Information System (INIS)

Jones, Peter A.R.; Taylor, Marika

2016-01-01

We explore holographic entanglement entropy in ten-dimensional supergravity solutions. It has been proposed that entanglement entropy can be computed in such top-down models using minimal surfaces which asymptotically wrap the compact part of the geometry. We show explicitly in a wide range of examples that the holographic entanglement entropy thus computed agrees with the entanglement entropy computed using the Ryu-Takayanagi formula from the lower-dimensional Einstein metric obtained from reduction over the compact space. Our examples include not only consistent truncations but also cases in which no consistent truncation exists and Kaluza-Klein holography is used to identify the lower-dimensional Einstein metric. We then give a general proof, based on the Lewkowycz-Maldacena approach, of the top-down entanglement entropy formula.

Black Holes, Holography, and Quantum Error Correction

CERN Multimedia

CERN. Geneva

2017-01-01

How can it be that a local quantum field theory in some number of spacetime dimensions can "fake" a local gravitational theory in a higher number of dimensions?  How can the Ryu-Takayanagi Formula say that an entropy is equal to the expectation value of a local operator?  Why do such things happen only in gravitational theories?  In this talk I will explain how a new interpretation of the AdS/CFT correspondence as a quantum error correcting code provides satisfying answers to these questions, and more generally gives a natural way of generating simple models of the correspondence.  No familiarity with AdS/CFT or quantum error correction is assumed, but the former would still be helpful.  

Quantum corrections to holographic mutual information

Energy Technology Data Exchange (ETDEWEB)

Agón, Cesar A. [Martin Fisher School of Physics, Brandeis University,Waltham, MA 02453 (United States); Faulkner, Thomas [University of Illinois, Urbana-Champaign,Urbana, IL 61801-3080 (United States)

2016-08-22

We compute the leading contribution to the mutual information (MI) of two disjoint spheres in the large distance regime for arbitrary conformal field theories (CFT) in any dimension. This is achieved by refining the operator product expansion method introduced by Cardy http://dx.doi.org/10.1088/1751-8113/46/28/285402. For CFTs with holographic duals the leading contribution to the MI at long distances comes from bulk quantum corrections to the Ryu-Takayanagi area formula. According to the FLM proposal http://dx.doi.org/10.1007/JHEP11(2013)074 this equals the bulk MI between the two disjoint regions spanned by the boundary spheres and their corresponding minimal area surfaces. We compute this quantum correction and provide in this way a non-trivial check of the FLM proposal.

Quantum corrections to holographic mutual information

International Nuclear Information System (INIS)

Agón, Cesar A.; Faulkner, Thomas

2016-01-01

We compute the leading contribution to the mutual information (MI) of two disjoint spheres in the large distance regime for arbitrary conformal field theories (CFT) in any dimension. This is achieved by refining the operator product expansion method introduced by Cardy http://dx.doi.org/10.1088/1751-8113/46/28/285402. For CFTs with holographic duals the leading contribution to the MI at long distances comes from bulk quantum corrections to the Ryu-Takayanagi area formula. According to the FLM proposal http://dx.doi.org/10.1007/JHEP11(2013)074 this equals the bulk MI between the two disjoint regions spanned by the boundary spheres and their corresponding minimal area surfaces. We compute this quantum correction and provide in this way a non-trivial check of the FLM proposal.

Holographic entanglement in a noncommutative gauge theory

International Nuclear Information System (INIS)

Fischler, Willy; Kundu, Arnab; Kundu, Sandipan

2014-01-01

In this article we investigate aspects of entanglement entropy and mutual information in a large-N strongly coupled noncommutative gauge theory, both at zero and at finite temperature. Using the gauge-gravity duality and the Ryu-Takayanagi (RT) prescription, we adopt a scheme for defining spatial regions on such noncommutative geometries and subsequently compute the corresponding entanglement entropy. We observe that for regions which do not lie entirely in the noncommutative plane, the RT-prescription yields sensible results. In order to make sense of the divergence structure of the corresponding entanglement entropy, it is essential to introduce an additional cut-off in the theory. For regions which lie entirely in the noncommutative plane, the corresponding minimal area surfaces can only be defined at this cut-off and they have distinctly peculiar properties

Subtemporal approach to basilar tip aneurysm with division of posterior communicating artery: Technical note

Directory of Open Access Journals (Sweden)

Shunsuke Kakino

2008-08-01

Full Text Available Shunsuke Kakino, Kuniaki Ogasawara, Yoshitaka Kubo, Hideaki Nishimoto, Akira OgawaDepartment of Neurosurgery, Iwate Medical University School of Medicine, Morioka, Iwate, JapanAbstract: The subtemporal approach with division of the posterior communicating artery (PcomA is described for treating aneurysms of the basilar tip. When the ipsilateral posterior cerebral artery (PCA interferes with visibility and manipulation around the aneurysm neck and the artery is tethered by the PcomA and not mobilized, the PcomA can be divided near the junction with the PCA. The procedure permits PCA mobilization and exposes the neck of the aneurysm. We applied this procedure to a patient with a ruptured aneurysm of the basilar tip. The postoperative course was uneventful except for transient left oculomotor nerve palsy. Postoperative cerebral angiography and magnetic resonance imaging confirmed the respective disappearance of the aneurysm and no new ischemic lesions. The subtemporal approach allows safer and easier division of the PcomA near the junction to the PCA compared with the pterional approach, and the present procedure is more suitable for the subtemporal approach.Keywords: basilar tip aneurysm, subtemporal approach, posterior communicating artery

Higher Curvature Gravity from Entanglement in Conformal Field Theories

Science.gov (United States)

Haehl, Felix M.; Hijano, Eliot; Parrikar, Onkar; Rabideau, Charles

2018-05-01

By generalizing different recent works to the context of higher curvature gravity, we provide a unifying framework for three related results: (i) If an asymptotically anti-de Sitter (AdS) spacetime computes the entanglement entropies of ball-shaped regions in a conformal field theory using a generalized Ryu-Takayanagi formula up to second order in state deformations around the vacuum, then the spacetime satisfies the correct gravitational equations of motion up to second order around the AdS background. (ii) The holographic dual of entanglement entropy in higher curvature theories of gravity is given by the Wald entropy plus a particular correction term involving extrinsic curvatures. (iii) Conformal field theory relative entropy is dual to gravitational canonical energy (also in higher curvature theories of gravity). Especially for the second point, our novel derivation of this previously known statement does not involve the Euclidean replica trick.

Static elliptic minimal surfaces in AdS{sub 4}

Energy Technology Data Exchange (ETDEWEB)

Pastras, Georgios [NCSR ' ' Demokritos' ' , Institute of Nuclear and Particle Physics, Attiki (Greece)

2017-11-15

The Ryu-Takayanagi conjecture connects the entanglement entropy in the boundary CFT to the area of open co-dimension two minimal surfaces in the bulk. Especially in AdS{sub 4}, the latter are two-dimensional surfaces, and, thus, solutions of a Euclidean non-linear sigma model on a symmetric target space that can be reduced to an integrable system via Pohlmeyer reduction. In this work, we construct static minimal surfaces in AdS{sub 4} that correspond to elliptic solutions of the reduced system, namely the cosh-Gordon equation, via the inversion of Pohlmeyer reduction. The constructed minimal surfaces comprise a two-parameter family of surfaces that include helicoids and catenoids in H{sup 3} as special limits. Minimal surfaces that correspond to identical boundary conditions are discovered within the constructed family of surfaces and the relevant geometric phase transitions are studied. (orig.)

ER=EPR, GHZ, and the consistency of quantum measurements

International Nuclear Information System (INIS)

Susskind, Leonard

2016-01-01

This paper illustrates various aspects of the ER=EPR conjecture. It begins with a brief heuristic argument, using the Ryu-Takayanagi correspondence, for why entanglement between black holes implies the existence of Einstein-Rosen bridges. The main part of the paper addresses a fundamental question: Is ER=EPR consistent with the standard postulates of quantum mechanics? Naively it seems to lead to an inconsistency between observations made on entangled systems by different observers. The resolution of the paradox lies in the properties of multiple black holes, entangled in the Greenberger-Horne-Zeilinger pattern. The last part of the paper is about entanglement as a resource for quantum communication. ER=EPR provides a way to visualize protocols like quantum teleportation. In some sense teleportation takes place through the wormhole, but as usual, classical communication is necessary to complete the protocol. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

ER=EPR, GHZ, and the consistency of quantum measurements

Energy Technology Data Exchange (ETDEWEB)

Susskind, Leonard [Stanford Institute for Theoretical Physics and Department of Physics, Stanford University, Stanford, CA (United States)

2016-01-15

This paper illustrates various aspects of the ER=EPR conjecture. It begins with a brief heuristic argument, using the Ryu-Takayanagi correspondence, for why entanglement between black holes implies the existence of Einstein-Rosen bridges. The main part of the paper addresses a fundamental question: Is ER=EPR consistent with the standard postulates of quantum mechanics? Naively it seems to lead to an inconsistency between observations made on entangled systems by different observers. The resolution of the paradox lies in the properties of multiple black holes, entangled in the Greenberger-Horne-Zeilinger pattern. The last part of the paper is about entanglement as a resource for quantum communication. ER=EPR provides a way to visualize protocols like quantum teleportation. In some sense teleportation takes place through the wormhole, but as usual, classical communication is necessary to complete the protocol. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

A theoretical analysis on vibrational-energy transfers in gases

International Nuclear Information System (INIS)

Mastrocinque, G.

1981-01-01

In order to investigate the relationships between three-dimensional and colinear molecular-collision models with particular emphasis on the role of repulsive and attractive forces in vibrational-energy transfers in gases, a theoretical analysis is developed in this paper. A few known results - mainly the Cottrell and Ream equation, the Takayanagi and the Shin expressions of the transfer probability - relevant to repulsive-force-dominated processes are obtained and/or discussed in the proposed frame. Light is also given on long-range, attractive-forces-dominated processes. The main result of this investigation is that, when a suitable hypothesis is done on the transfer probability, centrifugal effects on the intermolecular trajectories due to standard potentials are negligible in the low-temperature range. A quasi-colinear collision model, which is found to be correlated to the Cottrell and Ream expression for the transfer probability, is regained from a three-dimensional geometry in these conditions. (author)

Bulk entanglement gravity without a boundary: Towards finding Einstein's equation in Hilbert space

Science.gov (United States)

Cao, ChunJun; Carroll, Sean M.

2018-04-01

We consider the emergence from quantum entanglement of spacetime geometry in a bulk region. For certain classes of quantum states in an appropriately factorized Hilbert space, a spatial geometry can be defined by associating areas along codimension-one surfaces with the entanglement entropy between either side. We show how radon transforms can be used to convert these data into a spatial metric. Under a particular set of assumptions, the time evolution of such a state traces out a four-dimensional spacetime geometry, and we argue using a modified version of Jacobson's "entanglement equilibrium" that the geometry should obey Einstein's equation in the weak-field limit. We also discuss how entanglement equilibrium is related to a generalization of the Ryu-Takayanagi formula in more general settings, and how quantum error correction can help specify the emergence map between the full quantum-gravity Hilbert space and the semiclassical limit of quantum fields propagating on a classical spacetime.

Preoperative diagnosis of pelvic actinomycosis by clinical cytology

Directory of Open Access Journals (Sweden)

Matsuda K

2012-09-01

Full Text Available Katsuya Matsuda,1 Hisayoshi Nakajima,2 Khaleque N Khan,1 Terumi Tanigawa,1 Daisuke Hamaguchi,1 Michio Kitajima,1 Koichi Hiraki,1 Shingo Moriyama,3 Hideaki Masuzaki11Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, 2Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, 3Shimabara Maternity Clinic, Nagasaki, JapanBackground: The purpose of this work was to investigate whether clinical cytology could be useful in the preoperative diagnosis of pelvic actinomycosis.Methods: This study involved the prospective collection of samples derived from the endometrium and the uterine cervix, and retrospective data analysis. Nine patients with clinically diagnosed pelvic actinomycosis were enrolled. The clinical and hematological characteristics of patients were recorded, and detection of actinomyces was performed by cytology, pathology, and bacteriological culture of samples and by imprint intrauterine contraceptive device (IUD cytology.Results: The detection rate of actinomyces was 77.7% by combined cervical and endometrial cytology, 50.0% by pathology, and 11.1% by bacterial culture.Conclusion: The higher detection rate of actinomyces by cytology than by pathology or bacteriology suggests that careful cytological examination may be clinically useful in the preoperative diagnosis of pelvic actinomycosis.Keywords: actinomycosis, cytology, pathology, intrauterine contraceptive device, pelvic inflammatory disease

Living on the edge: a toy model for holographic reconstruction of algebras with centers

Energy Technology Data Exchange (ETDEWEB)

Donnelly, William; Marolf, Donald; Michel, Ben; Wien, Jason [Department of Physics, University of California,Santa Barbara, CA 93106 (United States)

2017-04-18

We generalize the Pastawski-Yoshida-Harlow-Preskill (HaPPY) holographic quantum error-correcting code to provide a toy model for bulk gauge fields or linearized gravitons. The key new elements are the introduction of degrees of freedom on the links (edges) of the associated tensor network and their connection to further copies of the HaPPY code by an appropriate isometry. The result is a model in which boundary regions allow the reconstruction of bulk algebras with central elements living on the interior edges of the (greedy) entanglement wedge, and where these central elements can also be reconstructed from complementary boundary regions. In addition, the entropy of boundary regions receives both Ryu-Takayanagi-like contributions and further corrections that model the ((δArea)/(4G{sub N})) term of Faulkner, Lewkowycz, and Maldacena. Comparison with Yang-Mills theory then suggests that this ((δArea)/(4G{sub N})) term can be reinterpreted as a part of the bulk entropy of gravitons under an appropriate extension of the physical bulk Hilbert space.

Living on the edge: a toy model for holographic reconstruction of algebras with centers

International Nuclear Information System (INIS)

Donnelly, William; Marolf, Donald; Michel, Ben; Wien, Jason

2017-01-01

We generalize the Pastawski-Yoshida-Harlow-Preskill (HaPPY) holographic quantum error-correcting code to provide a toy model for bulk gauge fields or linearized gravitons. The key new elements are the introduction of degrees of freedom on the links (edges) of the associated tensor network and their connection to further copies of the HaPPY code by an appropriate isometry. The result is a model in which boundary regions allow the reconstruction of bulk algebras with central elements living on the interior edges of the (greedy) entanglement wedge, and where these central elements can also be reconstructed from complementary boundary regions. In addition, the entropy of boundary regions receives both Ryu-Takayanagi-like contributions and further corrections that model the ((δArea)/(4G N )) term of Faulkner, Lewkowycz, and Maldacena. Comparison with Yang-Mills theory then suggests that this ((δArea)/(4G N )) term can be reinterpreted as a part of the bulk entropy of gravitons under an appropriate extension of the physical bulk Hilbert space.

Holographic quantum error-correcting codes: toy models for the bulk/boundary correspondence

Energy Technology Data Exchange (ETDEWEB)

Pastawski, Fernando; Yoshida, Beni [Institute for Quantum Information & Matter and Walter Burke Institute for Theoretical Physics,California Institute of Technology,1200 E. California Blvd., Pasadena CA 91125 (United States); Harlow, Daniel [Princeton Center for Theoretical Science, Princeton University,400 Jadwin Hall, Princeton NJ 08540 (United States); Preskill, John [Institute for Quantum Information & Matter and Walter Burke Institute for Theoretical Physics,California Institute of Technology,1200 E. California Blvd., Pasadena CA 91125 (United States)

2015-06-23

We propose a family of exactly solvable toy models for the AdS/CFT correspondence based on a novel construction of quantum error-correcting codes with a tensor network structure. Our building block is a special type of tensor with maximal entanglement along any bipartition, which gives rise to an isometry from the bulk Hilbert space to the boundary Hilbert space. The entire tensor network is an encoder for a quantum error-correcting code, where the bulk and boundary degrees of freedom may be identified as logical and physical degrees of freedom respectively. These models capture key features of entanglement in the AdS/CFT correspondence; in particular, the Ryu-Takayanagi formula and the negativity of tripartite information are obeyed exactly in many cases. That bulk logical operators can be represented on multiple boundary regions mimics the Rindler-wedge reconstruction of boundary operators from bulk operators, realizing explicitly the quantum error-correcting features of AdS/CFT recently proposed in http://dx.doi.org/10.1007/JHEP04(2015)163.

On volumes of subregions in holography and complexity

Energy Technology Data Exchange (ETDEWEB)

Ben-Ami, Omer [Raymond and Beverly Sackler Faculty of Exact Sciences School of Physics and Astronomy,Tel-Aviv University, Ramat-Aviv, 69978 (Israel); Carmi, Dean [Raymond and Beverly Sackler Faculty of Exact Sciences School of Physics and Astronomy,Tel-Aviv University, Ramat-Aviv, 69978 (Israel); Perimeter Institute for Theoretical Physics,31 Caroline Street North, ON, N2L 2Y5 (Canada)

2016-11-22

The volume of the region inside the bulk Ryu-Takayanagi surface is a codimension-one object, and a natural generalization of holographic complexity to the case of subregions in the boundary QFT. We focus on time-independent geometries, and study the properties of this volume in various circumstances. We derive a formula for computing the volume for a strip entangling surface and a general asymptotically AdS bulk geometry. For an AdS black hole geometry, the volume exhibits non-monotonic behaviour as a function of the size of the entangling region (unlike the behaviour of the entanglement entropy in this setup, which is monotonic). For setups in which the holographic entanglement entropy exhibits transitions in the bulk, such as global AdS black hole, geometries dual to confining theories and disjoint entangling surfaces, the corresponding volume exhibits a discontinuous finite jump at the transition point (and so do the volumes of the corresponding entanglement wedges). We compute this volume discontinuity in several examples. Lastly, we compute the codim-zero volume and the bulk action of the entanglement wedge for the case of a sphere entangling surface and pure AdS geometry.

Gravitation from entanglement in holographic CFTs

Energy Technology Data Exchange (ETDEWEB)

Faulkner, Thomas [Institute for Advanced Study,Princeton, NJ 08540 (United States); Guica, Monica [Department of Physics and Astronomy, University of Pennsylvania,209 S. 33rd St., Philadelphia, PA 19104-6396 (United States); Hartman, Thomas [Kavli Institute for Theoretical Physics, University of California,Santa Barbara, CA 93106-4030 (United States); Myers, Robert C. [Perimeter Institute for Theoretical Physics,31 Caroline Street N., Waterloo, Ontario N2L 2Y5 (Canada); Raamsdonk, Mark Van [Department of Physics and Astronomy, University of British Columbia,6224 Agricultural Road, Vancouver, B.C. V6T 1W9 (Canada)

2014-03-11

Entanglement entropy obeys a ‘first law’, an exact quantum generalization of the ordinary first law of thermodynamics. In any CFT with a semiclassical holographic dual, this first law has an interpretation in the dual gravitational theory as a constraint on the spacetimes dual to CFT states. For small perturbations around the CFT vacuum state, we show that the set of such constraints for all ball-shaped spatial regions in the CFT is exactly equivalent to the requirement that the dual geometry satisfy the gravitational equations of motion, linearized about pure AdS. For theories with entanglement entropy computed by the Ryu-Takayanagi formula S=A/(4G{sub N}), we obtain the linearized Einstein equations. For theories in which the vacuum entanglement entropy for a ball is computed by more general Wald functionals, we obtain the linearized equations for the associated higher-curvature theories. Using the first law, we also derive the holographic dictionary for the stress tensor, given the holographic formula for entanglement entropy. This method provides a simple alternative to holographic renormalization for computing the stress tensor expectation value in arbitrary higher derivative gravitational theories.

Introduction to the AdS/CFT Correspondence

Science.gov (United States)

Nąstase, Horaǧiu

2015-09-01

Preface; Introduction; Part I. Background: 1. Elements of quantum field theory and gauge theory; 2. Basics of general relativity. Anti-de Sitter space; 3. Basics of supersymmetry; 4. Basics of supergravity; 5. Kaluza-Klein dimensional reduction; 6. Black holes and p-branes; 7. String theory actions and spectra; 8. Elements of conformal field theory; 9. D-branes; Part II. Basics of AdS/CFT for N = 4 SYM vs AdS5 × S5: 10. The AdS/CFT correspondence: motivation, definition and spectra; 11. Witten prescription and 3-point correlator calculations; 12. Holography in Lorentzian signature: Poincaré and global; 13. Solitonic objects in AdS/CFT; 14. Quarks and the Wilson loop; 15. Finite temperature and N = 4 SYM plasmas; 16. Scattering processes and gravitational shockwave limit; 17. The pp-wave correspondence; 18. Spin chains; Part III. AdS/CFT Developments and Gauge-Gravity Dualities: 19. Other conformal cases; 20. The 3 dimensional ABJM model vs. AdS4 × CP3; 21. Gravity duals; 22. Holographic renormalization; 23. RG flow between fixed points; 24. Phenomenological gauge-gravity duality I: AdS/QCD; 25. Phenomenological gauge-gravity duality II: AdS/CMT; 26. Gluon scattering: the Alday-Maldacena prescription; 27. Holographic entanglement entropy: the Ryu-Takayanagi prescription.

Entanglement from dissipation and holographic interpretation

Science.gov (United States)

Cantcheff, M. Botta; Gadelha, Alexandre L.; Marchioro, Dáfni F. Z.; Nedel, Daniel Luiz

2018-02-01

In this work we study a dissipative field theory where the dissipation process is manifestly related to dynamical entanglement and put it in the holographic context. Such endeavour is realized by further development of a canonical approach to study quantum dissipation, which consists of doubling the degrees of freedom of the original system by defining an auxiliary one. A time dependent entanglement entropy for the vacumm state is calculated and a geometrical interpretation of the auxiliary system and the entropy is given in the context of the AdS/CFT correspondence using the Ryu-Takayanagi formula. We show that the dissipative dynamics is controlled by the entanglement entropy and there are two distinct stages: in the early times the holographic interpretation requires some deviation from classical General Relativity; in the later times the quantum system is described as a wormhole, a solution of the Einstein's equations near to a maximally extended black hole with two asymptotically AdS boundaries. We focus our holographic analysis in this regime, and suggest a mechanism similar to teleportation protocol to exchange (quantum) information between the two CFTs on the boundaries (see Maldacena et al. in Fortschr Phys 65(5):1700034, arXiv:1704.05333 [hep-th], 2017).

Entanglement from dissipation and holographic interpretation

Energy Technology Data Exchange (ETDEWEB)

Cantcheff, M.B. [IFLP-CONICET CC 67, La Plata, Buenos Aires (Argentina); Gadelha, Alexandre L. [Universidade Federal da Bahia, Instituto de Fisica, Salvador, BA (Brazil); Marchioro, Dafni F.Z.; Nedel, Daniel Luiz [Universidade Federal da Integracao Latino-Americana, Instituto Latino-Americano de Ciencias da Vida e da Natureza, Foz do Iguacu, PR (Brazil)

2018-02-15

In this work we study a dissipative field theory where the dissipation process is manifestly related to dynamical entanglement and put it in the holographic context. Such endeavour is realized by further development of a canonical approach to study quantum dissipation, which consists of doubling the degrees of freedom of the original system by defining an auxiliary one. A time dependent entanglement entropy for the vacuum state is calculated and a geometrical interpretation of the auxiliary system and the entropy is given in the context of the AdS/CFT correspondence using the Ryu-Takayanagi formula. We show that the dissipative dynamics is controlled by the entanglement entropy and there are two distinct stages: in the early times the holographic interpretation requires some deviation from classical General Relativity; in the later times the quantum system is described as a wormhole, a solution of the Einstein's equations near to a maximally extended black hole with two asymptotically AdS boundaries. We focus our holographic analysis in this regime, and suggest a mechanism similar to teleportation protocol to exchange (quantum) information between the two CFTs on the boundaries (see Maldacena et al. in Fortschr Phys 65(5):1700034, arXiv:1704.05333 [hep-th], 2017). (orig.)

A stereoscopic look into the bulk

Energy Technology Data Exchange (ETDEWEB)

Czech, Bartłomiej; Lamprou, Lampros; McCandlish, Samuel; Mosk, Benjamin [Stanford Institute for Theoretical Physics, Department of Physics, Stanford University,Stanford, CA 94305 (United States); Sully, James [Theory Group, SLAC National Accelerator LaboratoryMenlo Park, CA 94025 (United States)

2016-07-26

We present the foundation for a holographic dictionary with depth perception. The dictionary consists of natural CFT operators whose duals are simple, diffeomorphism-invariant bulk operators. The CFT operators of interest are the “OPE blocks,” contributions to the OPE from a single conformal family. In holographic theories, we show that the OPE blocks are dual at leading order in 1/N to integrals of effective bulk fields along geodesics or homogeneous minimal surfaces in anti-de Sitter space. One widely studied example of an OPE block is the modular Hamiltonian, which is dual to the fluctuation in the area of a minimal surface. Thus, our operators pave the way for generalizing the Ryu-Takayanagi relation to other bulk fields. Although the OPE blocks are non-local operators in the CFT, they admit a simple geometric description as fields in kinematic space — the space of pairs of CFT points. We develop the tools for constructing local bulk operators in terms of these non-local objects. The OPE blocks also allow for conceptually clean and technically simple derivations of many results known in the literature, including linearized Einstein’s equations and the relation between conformal blocks and geodesic Witten diagrams.

In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta

Directory of Open Access Journals (Sweden)

Kobayashi A

2014-02-01

Full Text Available Akira Kobayashi, Tomomi Higashide, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Objective: To report the in vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta (OI with special attention to the abnormality of Bowman's layer and sub-Bowman's fibrous structures (K-structures. Patients and methods: Two patients (67-year-old male and his 26-year-old son with OI type I were included in this study. Slit lamp biomicroscopic and in vivo laser confocal microscopic examinations were performed for both patients. Central corneal thickness and central endothelial cell density were also measured. Results: Although the corneas looked clear with normal endothelial density for both eyes in both patients, they were quite thin (386 µm oculus dexter (OD (the right eye and 384 µm oculus sinister (OS (the left eye in the father and 430 µm OD and 425 µm OS in the son. In both patients, slit lamp biomicroscopic and in vivo laser confocal microscopic examination showed similar results. Anterior corneal mosaics produced by rubbing the eyelid under fluorescein were completely absent in both eyes. In vivo laser confocal microscopy revealed an absent or atrophic Bowman's layer; a trace of a presumed Bowman's layer and/or basement membrane was barely visible with high intensity. Additionally, K-structures were completely absent in both eyes. Conclusion: The absence of K-structures and fluorescein anterior corneal mosaics strongly suggested an abnormality of Bowman's layer in these OI patients. Keywords: osteogenesis imperfecta, K-structure, confocal microscopy, Bowman's layer

Emergent Geometry from Entropy and Causality

Science.gov (United States)

Engelhardt, Netta

In this thesis, we investigate the connections between the geometry of spacetime and aspects of quantum field theory such as entanglement entropy and causality. This work is motivated by the idea that spacetime geometry is an emergent phenomenon in quantum gravity, and that the physics responsible for this emergence is fundamental to quantum field theory. Part I of this thesis is focused on the interplay between spacetime and entropy, with a special emphasis on entropy due to entanglement. In general spacetimes, there exist locally-defined surfaces sensitive to the geometry that may act as local black hole boundaries or cosmological horizons; these surfaces, known as holographic screens, are argued to have a connection with the second law of thermodynamics. Holographic screens obey an area law, suggestive of an association with entropy; they are also distinguished surfaces from the perspective of the covariant entropy bound, a bound on the total entropy of a slice of the spacetime. This construction is shown to be quite general, and is formulated in both classical and perturbatively quantum theories of gravity. The remainder of Part I uses the Anti-de Sitter/ Conformal Field Theory (AdS/CFT) correspondence to both expand and constrain the connection between entanglement entropy and geometry. The AdS/CFT correspondence posits an equivalence between string theory in the "bulk" with AdS boundary conditions and certain quantum field theories. In the limit where the string theory is simply classical General Relativity, the Ryu-Takayanagi and more generally, the Hubeny-Rangamani-Takayanagi (HRT) formulae provide a way of relating the geometry of surfaces to entanglement entropy. A first-order bulk quantum correction to HRT was derived by Faulkner, Lewkowycz and Maldacena. This formula is generalized to include perturbative quantum corrections in the bulk at any (finite) order. Hurdles to spacetime emergence from entanglement entropy as described by HRT and its quantum

Gravity from entanglement and RG flow in a top-down approach

Science.gov (United States)

Kwon, O.-Kab; Jang, Dongmin; Kim, Yoonbai; Tolla, D. D.

2018-05-01

The duality between a d-dimensional conformal field theory with relevant deformation and a gravity theory on an asymptotically AdS d+1 geometry, has become a suitable tool in the investigation of the emergence of gravity from quantum entanglement in field theory. Recently, we have tested the duality between the mass-deformed ABJM theory and asymptotically AdS4 gravity theory, which is obtained from the KK reduction of the 11-dimensional supergravity on the LLM geometry. In this paper, we extend the KK reduction procedure beyond the linear order and establish non-trivial KK maps between 4-dimensional fields and 11-dimensional fluctuations. We rely on this gauge/gravity duality to calculate the entanglement entropy by using the Ryu-Takayanagi holographic formula and the path integral method developed by Faulkner. We show that the entanglement entropies obtained using these two methods agree when the asymptotically AdS4 metric satisfies the linearized Einstein equation with nonvanishing energy-momentum tensor for two scalar fields. These scalar fields encode the information of the relevant deformation of the ABJM theory. This confirms that the asymptotic limit of LLM geometry is the emergent gravity of the quantum entanglement in the mass-deformed ABJM theory with a small mass parameter. We also comment on the issue of the relative entropy and the Fisher information in our setup.

Randomized Phase II trial of paclitaxel plus valproic acid vs paclitaxel alone as second-line therapy for patients with advanced gastric cancer

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Fushida S

2015-04-01

Full Text Available Sachio Fushida,1 Masahide Kaji,2 Katsunobu Oyama,1 Yasuo Hirono,3 Hideaki Nezuka,4 Toshiya Takeda,5 Tomoya Tsukada,1 Daisuke Fujimoto,3 Shigekazu Ohyama,6 Takashi Fujimura,7 Tetsuo Ohta1 On behalf of the Digestive Disease Support Organization (DDSO 1Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, 2Department of Surgery, Toyama Prefectural Central Hospital, Toyama, 3First Department of Surgery, Fukui University Hospital, Fukui, 4Department of Surgery, Yatsuo General Hospital, Toyama, 5Department of Surgery, Ishikawa Matto Central Hospital, Hakusan, 6Department of Surgery, Kanazawa Medical Center, Kanazawa, 7Toyama City Hospital, Toyama, Japan Abstract: The standard regimen of second-line chemotherapy for patients with unresectable gastric cancer has not been established. However, weekly paclitaxel (wPTX has become the preferable second-line chemotherapy in Japan. Histone deacetylase (HDAC inhibitors have been shown to have antiproliferative activity through cell-cycle arrest, differentiation, and apoptosis in gastric cancer cells. One HDAC inhibitor, valproic acid (VPA, also inhibits tumor growth by inducing apoptosis, and enhances the efficacy of paclitaxel in a mouse xenograft model of gastric cancer. wPTX plus VPA as a second-line chemotherapy is expected to improve survival in gastric cancer patients. A multicenter randomized Phase II study was conducted to compare the effects of wPTX plus VPA and wPTX alone. A total of 66 patients participated in this study. The primary end point of the study was overall survival, and secondary end points were progression-free survival, response rate, and assessment of peripheral neuropathy. Keywords: valproic acid, paclitaxel, second-line therapy, advanced gastric cancer 

Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital

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Yokogawa H

2014-10-01

Full Text Available Hideaki Yokogawa, Akira Kobayashi, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanPurpose: To report surgical therapies for corneal perforations in a tertiary referral hospital.Methods: Thirty-one eyes of 31 patients (aged 62.4±18.3 years with surgically treated corneal perforations from January 2002 to July 2013 were included in this study. Demographic data such as cause of corneal perforation, surgical procedures, and visual outcomes were retrospectively analyzed.Results: The causes of corneal perforation (n=31 were divided into infectious (n=8, 26% and noninfectious (n=23, 74% categories. Infectious causes included fungal ulcer, herpetic stromal necrotizing keratitis, and bacterial ulcer. The causes of noninfectious keratopathy included corneal melting after removal of a metal foreign body, severe dry eye, lagophthalmos, canaliculitis, the oral anticancer drug S-1, keratoconus, rheumatoid arthritis, neurotrophic ulcer, atopic keratoconjunctivitis, and unknown causes. Initial surgical procedures included central large corneal graft (n=17, small corneal graft (n=7, and amniotic membrane transplantation (n=7. In two cases the perforation could not be sealed during the first surgical treatment and required subsequent procedures. All infectious keratitis required central large penetrating keratoplasty to obtain anatomical cure. In contrast, several surgical options were used for the treatment of noninfectious keratitis. After surgical treatment, anatomical cure was obtained in all cases. Mean postoperative best corrected visual acuity was better at 6 months (logMAR 1.3 than preoperatively (logMAR 1.8.Conclusion: Surgical therapies for corneal perforations in our hospital included central large lamellar/penetrating keratoplasty, small peripheral patch graft, and amniotic membrane transplantation. All treatments were effective. Corneal

Does horizon entropy satisfy a quantum null energy conjecture?

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Fu, Zicao; Marolf, Donald

2016-12-01

A modern version of the idea that the area of event horizons gives 4G times an entropy is the Hubeny-Rangamani causal holographic information (CHI) proposal for holographic field theories. Given a region R of a holographic QFTs, CHI computes A/4G on a certain cut of an event horizon in the gravitational dual. The result is naturally interpreted as a coarse-grained entropy for the QFT. CHI is known to be finitely greater than the fine-grained Hubeny-Rangamani-Takayanagi (HRT) entropy when \\partial R lies on a Killing horizon of the QFT spacetime, and in this context satisfies other non-trivial properties expected of an entropy. Here we present evidence that it also satisfies the quantum null energy condition (QNEC), which bounds the second derivative of the entropy of a quantum field theory on one side of a non-expanding null surface by the flux of stress-energy across the surface. In particular, we show CHI to satisfy the QNEC in 1  +  1 holographic CFTs when evaluated in states dual to conical defects in AdS3. This surprising result further supports the idea that CHI defines a useful notion of coarse-grained holographic entropy, and suggests unprecedented bounds on the rate at which bulk horizon generators emerge from a caustic. To supplement our motivation, we include an appendix deriving a corresponding coarse-grained generalized second law for 1  +  1 holographic CFTs perturbatively coupled to dilaton gravity.

Value of systematic intervention for chronic obstructive pulmonary disease in a regional Japanese city based on case detection rate and medical cost

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Tawara Y

2015-08-01

Full Text Available Yuichi Tawara,1 Hideaki Senjyu,1 Kenichiro Tanaka,1 Takako Tanaka,1 Masaharu Asai,1 Ryo Kozu,2 Mitsuru Tabusadani,3 Sumihisa Honda,1 Terumitsu Sawai1 1Department of Cardiopulmonary Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; 2Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, Japan; 3Center for Industry, University and Government Cooperation, Nagasaki University, Nagasaki, Japan Objective: We established a COPD taskforce for early detection, diagnosis, treatment, and intervention. We implemented a pilot intervention with a prospective and longitudinal design in a regional city. This study evaluates the usefulness of the COPD taskforce and intervention based on COPD case detection rate and per capita medical costs.Method: We distributed a questionnaire to all 8,878 inhabitants aged 50–89 years, resident in Matsuura, Nagasaki Prefecture in 2006. Potentially COPD-positive persons received a pulmonary function test and diagnosis. We implemented ongoing detection, examination, education, and treatment interventions, performed follow-up examinations or respiratory lessons yearly, and supported the health maintenance of each patient. We compared COPD medical costs in Matsuura and in the rest of Nagasaki Prefecture using data from 2004 to 2013 recorded by the association of Nagasaki National Health Insurance Organization, assessing 10-year means and annual change.Results: As of 2014, 256 people have received a definitive diagnosis of COPD; representing 31% of the estimated total number of COPD patients. Of the cases detected, 87.5% were mild or moderate in severity. COPD medical costs per patient in Matsuura were significantly lower than the rest of Nagasaki Prefecture, as was rate of increase in cost over time.Conclusion: The COPD program in Matsuura enabled early detection and treatment of COPD patients and helped to lower the associated burden of medical costs. The

Quantum Entanglement Growth under Random Unitary Dynamics

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Adam Nahum

2017-07-01

Full Text Available Characterizing how entanglement grows with time in a many-body system, for example, after a quantum quench, is a key problem in nonequilibrium quantum physics. We study this problem for the case of random unitary dynamics, representing either Hamiltonian evolution with time-dependent noise or evolution by a random quantum circuit. Our results reveal a universal structure behind noisy entanglement growth, and also provide simple new heuristics for the “entanglement tsunami” in Hamiltonian systems without noise. In 1D, we show that noise causes the entanglement entropy across a cut to grow according to the celebrated Kardar-Parisi-Zhang (KPZ equation. The mean entanglement grows linearly in time, while fluctuations grow like (time^{1/3} and are spatially correlated over a distance ∝(time^{2/3}. We derive KPZ universal behavior in three complementary ways, by mapping random entanglement growth to (i a stochastic model of a growing surface, (ii a “minimal cut” picture, reminiscent of the Ryu-Takayanagi formula in holography, and (iii a hydrodynamic problem involving the dynamical spreading of operators. We demonstrate KPZ universality in 1D numerically using simulations of random unitary circuits. Importantly, the leading-order time dependence of the entropy is deterministic even in the presence of noise, allowing us to propose a simple coarse grained minimal cut picture for the entanglement growth of generic Hamiltonians, even without noise, in arbitrary dimensionality. We clarify the meaning of the “velocity” of entanglement growth in the 1D entanglement tsunami. We show that in higher dimensions, noisy entanglement evolution maps to the well-studied problem of pinning of a membrane or domain wall by disorder.

Quantum Entanglement Growth under Random Unitary Dynamics

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Nahum, Adam; Ruhman, Jonathan; Vijay, Sagar; Haah, Jeongwan

2017-07-01

Characterizing how entanglement grows with time in a many-body system, for example, after a quantum quench, is a key problem in nonequilibrium quantum physics. We study this problem for the case of random unitary dynamics, representing either Hamiltonian evolution with time-dependent noise or evolution by a random quantum circuit. Our results reveal a universal structure behind noisy entanglement growth, and also provide simple new heuristics for the "entanglement tsunami" in Hamiltonian systems without noise. In 1D, we show that noise causes the entanglement entropy across a cut to grow according to the celebrated Kardar-Parisi-Zhang (KPZ) equation. The mean entanglement grows linearly in time, while fluctuations grow like (time )1/3 and are spatially correlated over a distance ∝(time )2/3. We derive KPZ universal behavior in three complementary ways, by mapping random entanglement growth to (i) a stochastic model of a growing surface, (ii) a "minimal cut" picture, reminiscent of the Ryu-Takayanagi formula in holography, and (iii) a hydrodynamic problem involving the dynamical spreading of operators. We demonstrate KPZ universality in 1D numerically using simulations of random unitary circuits. Importantly, the leading-order time dependence of the entropy is deterministic even in the presence of noise, allowing us to propose a simple coarse grained minimal cut picture for the entanglement growth of generic Hamiltonians, even without noise, in arbitrary dimensionality. We clarify the meaning of the "velocity" of entanglement growth in the 1D entanglement tsunami. We show that in higher dimensions, noisy entanglement evolution maps to the well-studied problem of pinning of a membrane or domain wall by disorder.

Entanglement, holography and causal diamonds

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de Boer, Jan; Haehl, Felix M.; Heller, Michal P.; Myers, Robert C.

2016-08-01

We argue that the degrees of freedom in a d-dimensional CFT can be reorganized in an insightful way by studying observables on the moduli space of causal diamonds (or equivalently, the space of pairs of timelike separated points). This 2 d-dimensional space naturally captures some of the fundamental nonlocality and causal structure inherent in the entanglement of CFT states. For any primary CFT operator, we construct an observable on this space, which is defined by smearing the associated one-point function over causal diamonds. Known examples of such quantities are the entanglement entropy of vacuum excitations and its higher spin generalizations. We show that in holographic CFTs, these observables are given by suitably defined integrals of dual bulk fields over the corresponding Ryu-Takayanagi minimal surfaces. Furthermore, we explain connections to the operator product expansion and the first law of entanglemententropy from this unifying point of view. We demonstrate that for small perturbations of the vacuum, our observables obey linear two-derivative equations of motion on the space of causal diamonds. In two dimensions, the latter is given by a product of two copies of a two-dimensional de Sitter space. For a class of universal states, we show that the entanglement entropy and its spin-three generalization obey nonlinear equations of motion with local interactions on this moduli space, which can be identified with Liouville and Toda equations, respectively. This suggests the possibility of extending the definition of our new observables beyond the linear level more generally and in such a way that they give rise to new dynamically interacting theories on the moduli space of causal diamonds. Various challenges one has to face in order to implement this idea are discussed.

Entanglement, holography and causal diamonds

Energy Technology Data Exchange (ETDEWEB)

Boer, Jan de [Institute of Physics, Universiteit van Amsterdam,Science Park 904, 1090 GL Amsterdam (Netherlands); Haehl, Felix M. [Centre for Particle Theory & Department of Mathematical Sciences, Durham University,South Road, Durham DH1 3LE (United Kingdom); Heller, Michal P.; Myers, Robert C. [Perimeter Institute for Theoretical Physics,31 Caroline Street North, Waterloo, Ontario N2L 2Y5 (Canada)

2016-08-29

We argue that the degrees of freedom in a d-dimensional CFT can be re-organized in an insightful way by studying observables on the moduli space of causal diamonds (or equivalently, the space of pairs of timelike separated points). This 2d-dimensional space naturally captures some of the fundamental nonlocality and causal structure inherent in the entanglement of CFT states. For any primary CFT operator, we construct an observable on this space, which is defined by smearing the associated one-point function over causal diamonds. Known examples of such quantities are the entanglement entropy of vacuum excitations and its higher spin generalizations. We show that in holographic CFTs, these observables are given by suitably defined integrals of dual bulk fields over the corresponding Ryu-Takayanagi minimal surfaces. Furthermore, we explain connections to the operator product expansion and the first law of entanglement entropy from this unifying point of view. We demonstrate that for small perturbations of the vacuum, our observables obey linear two-derivative equations of motion on the space of causal diamonds. In two dimensions, the latter is given by a product of two copies of a two-dimensional de Sitter space. For a class of universal states, we show that the entanglement entropy and its spin-three generalization obey nonlinear equations of motion with local interactions on this moduli space, which can be identified with Liouville and Toda equations, respectively. This suggests the possibility of extending the definition of our new observables beyond the linear level more generally and in such a way that they give rise to new dynamically interacting theories on the moduli space of causal diamonds. Various challenges one has to face in order to implement this idea are discussed.

Safety and effectiveness of rapid-acting intramuscular olanzapine for agitation associated with schizophrenia – Japan postmarketing surveillance study

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Katagiri H

2018-01-01

Full Text Available Hideaki Katagiri,1 Masanori Taketsuna,2 Shinpei Kondo,3 Kenta Kajimoto,4 Etsuko Aoi,5 Yuka Tanji1 1Bio Medicine, 2Statistical Sciences, 3Post Marketing Study Management, 4Scientific Communications, Medicines Development Unit Japan, 5Global Patient Safety Japan, Quality and Patient Safety, Eli Lilly Japan K.K., Kobe, Japan Objective: The objective of this study was to evaluate the safety and effectiveness of rapid-acting intramuscular (IM olanzapine in the treatment of acute agitation associated with schizophrenia in real-world clinical settings in Japan.Methods: In this multicenter, postmarketing surveillance (PMS study, patients with acute agitation associated with schizophrenia were treated with IM olanzapine daily in a daily clinical setting. The observational period ranged from 1 to 7 days, including the day of initial administration. Safety was assessed by reporting treatment-emergent adverse events (TEAEs and adverse drug reactions (ADRs. The Positive and Negative Syndrome Scale – Excited Component (PANSS-EC score was used to evaluate effectiveness at baseline and at 2 hours (after each administration, 2 days, and 3 days (end of the observational period from the last administration of the IM olanzapine injection.Results: The safety analysis set included 999 patients, and the initial dose of 10 mg was administered to 955 patients. TEAEs were reported in 28 patients (36 events, the most common of which were dyslalia (5 patients, akathisia and somno­lence (4 patients each, hepatic function abnormal (3 patients, and constipation and dehydration (2 patients each. One serious adverse event of akathisia occurred during the observation period. The PANSS-EC score (mean ± standard deviation was 23.3±6.4 (n=625 at baseline, 16.9±7.0 (n=522 at 2 hours after initial injection, and 14.9±6.5 (n=650 at the last observation carried forward.Conclusion: The results of this Japanese PMS study demonstrated that IM olanzapine is safe and has a

Silicon and Germanium (111) Surface Reconstruction

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Hao, You Gong

Silicon (111) surface (7 x 7) reconstruction has been a long standing puzzle. For the last twenty years, various models were put forward to explain this reconstruction, but so far the problem still remains unsolved. Recent ion scattering and channeling (ISC), scanning tunneling microscopy (STM) and transmission electron diffraction (TED) experiments reveal some new results about the surface which greatly help investigators to establish better models. This work proposes a silicon (111) surface reconstruction mechanism, the raising and lowering mechanism which leads to benzene -like ring and flower (raised atom) building units. Based on these building units a (7 x 7) model is proposed, which is capable of explaining the STM and ISC experiment and several others. Furthermore the building units of the model can be used naturally to account for the germanium (111) surface c(2 x 8) reconstruction and other observed structures including (2 x 2), (5 x 5) and (7 x 7) for germanium as well as the (/3 x /3)R30 and (/19 x /19)R23.5 impurity induced structures for silicon, and the higher temperature disordered (1 x 1) structure for silicon. The model is closely related to the silicon (111) surface (2 x 1) reconstruction pi-bonded chain model, which is the most successful model for the reconstruction now. This provides an explanation for the rather low conversion temperature (560K) of the (2 x 1) to the (7 x 7). The model seems to meet some problems in the explanation of the TED result, which is explained very well by the dimer, adatom and stacking fault (DAS) model proposed by Takayanagi. In order to explain the TED result, a variation of the atomic scattering factor is proposed. Comparing the benzene-like ring model with the DAS model, the former needs more work to explain the TED result and the later has to find a way to explain the silicon (111) surface (1 x 1) disorder experiment.

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD

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Funamoto M

2016-08-01

Full Text Available Masafumi Funamoto,1,2 Yoichi Sunagawa,1–3 Yasufumi Katanasaka,1–3 Yusuke Miyazaki,1,2 Atsushi Imaizumi,4 Hideaki Kakeya,5 Hajime Yamakage,2 Noriko Satoh-Asahara,2 Maki Komiyama,2 Hiromichi Wada,2 Koji Hasegawa,2 Tatsuya Morimoto1–3 1Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, 2Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, 3Shizuoka General Hospital, Shizuoka, 4Theravalues Corporation, Kioicho, Tokyo, 5Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan Purpose: COPD is mainly caused by tobacco smoking and is associated with a high frequency of coronary artery disease. There is growing recognition that the inflammation in COPD is not only confined to the lungs but also involves the systemic circulation and can impact nonpulmonary organs, including blood vessels. α1-antitrypsin–low-density lipoprotein (AT-LDL complex is an oxidatively modified LDL that accelerates atherosclerosis. Curcumin, one of the best-investigated natural products, is a powerful antioxidant. However, the effects of curcumin on AT-LDL remain unknown. We hypothesized that Theracurmin®, a highly absorptive curcumin with improved bioavailability using a drug delivery system, ameliorates the inflammatory status in subjects with mild COPD.Patients and methods: This is a randomized, double-blind, parallel-group study. Subjects with stages I–II COPD according to the Japanese Respiratory Society criteria were randomly assigned to receive 90 mg Theracurmin® or placebo twice a day for 24 weeks, and changes in inflammatory parameters were evaluated.Results: There were no differences between the Theracurmin® and placebo groups in terms of age, male/female ratio, or body mass index in 39 evaluable subjects. The percent changes in blood pressure

PREFACE: Nanospintronics design and realization

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Akai, Hisazumi; Katayama-Yoshida, Hiroshi; Kasai, Hideaki

2004-12-01

This special issue of Journal of Physics: Condensed Matter contains selected papers from the 1st International Conference on Nanospintronics Design and Realization (ICNDR 2004), which was held in Kyoto, Japan, 24--28 May 2004. This conference was organized by the Nanospintronics Design and Realization project members: Hideaki Kasai, Osaka (Chair of the Conference) Hisazumi Akai, Osaka Hajime Asahi, Osaka Wilson Agerico Diño, Osaka Hiroshi Harima, Kyoto Tomoyuki Kakeshita, Osaka Junjiro Kanamori, Kyoto Hiroshi Katayama-Yoshida, Osaka Koichi Kusakabe, Osaka Hiroshi Nakanishi, Osaka (Secretary) Tamio Oguchi, Hiroshima Teruo Ono, Osaka Naoshi Suzuki, Osaka Hitoshi Tabata, Osaka under the auspices of the Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT) Special Coordination Funds for Promoting Science and Technology, and the sponsorship of Osaka University and the International Institute for Advanced Studies (IIAS). The conference is intended to provide an international forum for experimental and theoretical researchers, in the rapidly developing field of nanospintronics. It aims to: provide an overview of our current understanding of the physics of spin transport in (magnetic) semiconductors and hybrid magnetic/semiconductor structures; provide a venue to present and discuss the latest developments in using spin-dependent phenomena in nano-(opto-) electronics and computing applications; provide a venue for discussion and assessment of other possible means of exploiting the spin-dependent phenomena in future nano-(opto-) electronic and computing applications; address current (and foreseeable future) problems, of fundamental and applied nature, in an effort to bridge the physics and technology gap between semiconducting and magnetic materials. All of these being geared towards bringing about the realization of a functioning nanospintronics. A total of 127 delegates from 15 countries took part in ICNDR 2004, which was comprised of 62 invited

The signs of ocular-surface disorders after switching from latanoprost to tafluprost/timolol fixed combination: a prospective study

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Okumichi H

2017-06-01

Full Text Available Hideaki Okumichi,1 Yoshiaki Kiuchi,1 Tetsuya Baba,2 Takashi Kanamoto,3 Tomoko Naito,4,5 Shunsuke Nakakura,6 Hitoshi Tabuchi,6 Hiroki Nii,7 Chie Sueoka,7 Yosuke Sugimoto1,8 1Department of Ophthalmology and Visual Science, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan; 2Shirai Eye Hospital, Mitoyo, Japan; 3Department of Ophthalmology, Hiroshima Memorial Hospital, Hiroshima, Japan; 4Department of Ophthalmology, Okayama University Graduate School of Medicine, Okayama, Japan; 5Department of Ophthalmology, Konko Hospital, Asakuchi, Japan; 6Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Japan; 7Department of Ophthalmology, Hiroshima General Hospital, Hiroshima, Japan; 8Department of Ophthalmology, Hiroshima Prefectural Hospital, Hiroshima, Japan Purpose: To evaluate the ocular-surface safety of a 0.001% benzalkonium chloride-containing tafluprost/timolol fixed combination (TTFC in patients with primary open-angle glaucoma (POAG or ocular hypertension who have inadequate intraocular pressure (IOP control with latanoprost monotherapy.Methods: This study is a multicenter, prospective, single-arm, open-label clinical study. Patients with POAG or ocular hypertension who have inadequate IOP control with latanoprost monotherapy were considered eligible. After providing informed consent, patients continued latanoprost monotherapy for 12 weeks, followed by a switch to TTFC. We evaluated the extent of ocular-surface damage using superficial punctate keratopathy (SPK score, tear breakup time (TBUT, hyperemia score, IOP, systolic blood pressure (SBP, diastolic blood pressure (DBP, and heart rate at 0, 4, and 12 weeks after switching.Results: A total of 68 patients were enrolled, of whom, 64 patients were included in the final analysis. No significant changes in SPK score, TBUT, or hyperemia score were observed at 4 and 12 weeks compared with week 0. IOP decreased significantly at 4 (13.9±2.5 mmHg and 12

Effectiveness and safety of oral olanzapine treatment transitioned from rapid-acting intramuscular olanzapine for agitation associated with schizophrenia

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Katagiri H

2018-04-01

Full Text Available Hideaki Katagiri,1 Masanori Taketsuna,2 Shinpei Kondo,3 Kenta Kajimoto,4 Etsuko Aoi,5 Yuka Tanji1 1Bio-Medicines, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 2Statistical Sciences, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 3Post Marketing Study Management, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 4Scientific Communications, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 5Global Patient Safety Japan, Quality and Patient Safety, Eli Lilly Japan K.K., Kobe, Japan Objective: To assess the effectiveness and safety of oral olanzapine treatment transitioned from rapid-acting intramuscular olanzapine (RAIM in patients with acute agitation associated with schizophrenia in a real-world clinical setting. Methods: The postmarketing surveillance study with a 3-day observational period after the last RAIM administration was conducted (original study. Following this, an extended study was added for patients who received oral olanzapine after RAIM administration during the original study period, in order to additionally observe them for 7 days after initial RAIM administration. Effectiveness and safety from initial RAIM administration were evaluated using the Positive and Negative Syndrome Scale-Excited Component score and treatment-emergent adverse events (TEAEs, respectively. Results: The effectiveness and safety analysis set included a total of 521 and 522 patients, respectively. A majority of patients received 10 mg of RAIM (475/522 patients, 91.0%. The mean ± SD total Positive and Negative Syndrome Scale-Excited Component score was 23.6±6.2 (n=318 at baseline (before initial RAIM administration, 17.4±6.8 (n=280 at 2 hours after initial administration, 16.2±6.8 (n=246 2 days after final administration, 14.9±6.2 (n=248 3 days after final administration, 13.8±5.9 (n=242 4 days after final administration, 13.2±5.8 (n=221 7 days after initial

PREFACE: 8th Asian International Seminar on Atomic and Molecular Physics (AISAMP)

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Williams, Jim F.; Buckman, Steve; Bieske, Evan J.

2009-09-01

These proceedings arose from the 8th Asian International Seminar on Atomic and Molecular Physics (AISAMP) which was held at the University of Western Australia 24-28 November 2008. The history of AISAMP (Takayanagi and Matsuzawa 2002) recognizes its origin from the Japan-China meeting of 1985, and the first use of the name 'The First Asian International Seminar on Atomic and Molecular Physics (AISAMP)' in 1992. The initial attendees, Japan and China, were joined subsequently by scientists from Korea, Taiwan, India, Australia and recently by Malaysia, Thailand, Vietnam, Turkey Iran, UK and USA. The main purpose of the biennial AISAMP series is to create a wide forum for exchanging ideas and information among atomic and molecular scientists and to promote international collaboration. The scope of the AISAMP8 meeting included pure, strategic and applied research involving atomic and molecular structure and processes in all forms of matter and antimatter. For 2008 the AISAMP conference incorporated the Australian Atomic and Molecular Physics and Quantum Chemistry meeting. The topics for AISAMP8 embraced themes from earlier AISAMP meetings and reflected new interests, in atomic and molecular structures, spectroscopy and collisions; atomic and molecular physics with laser or synchrotron radiation; quantum information processing using atoms and molecules; atoms and molecules in surface physics, nanotechnology, biophysics, atmospheric physics and other interdisciplinary studies. The implementation of the AISAMP themes, as well as the international representation of research interests, is indicated both in the contents list of these published manuscripts as well as in the program for the meeting. Altogether, 184 presentations were made at the 8th AISAMP, including Invited Talks and Contributed Poster Presentations, of which 60 appear in the present Proceedings after review by expert referees in accordance with the usual practice of Journal of Physics: Conference Series of

PREFACE: IUPAP C20 Conference on Computational Physics (CCP 2011)

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Troparevsky, Claudia; Stocks, George Malcolm

2012-12-01

McCurdy (Lawrence Berkeley National Laboratory, US) Ingrid Mertig (Martin Luther University, Germany) Alejandro Muramatsu (Universitat Stuttgart, Germany) Richard Needs (Cavendish Laboratory, UK) Giuseppina Orlandini (University of Trento, Italy) Martin Savage (University of Washington, US) Thomas Schulthess (ETH, Switzerland) Dzidka Szotek (Daresbury Laboratory, UK) Hideaki Takabe (Osaka University, Japan) William M. Tang (Princeton University, US) James Vary (Iowa State, US) Enge Wang (Chinese Academy of Science, China) Jian-Guo Wang (Institute of Applied Physics and Computational Mathematics, China) Jian-Sheng Wang (National University, Singapore) Dan Wei (Tsinghua University, China) Tony Williams (University of Adelaide, Australia) Rudy Zeller (Julich, Germany) Conference Administrator: Ann Strange (ORNL)

PREFACE: International Symposium on Non-Equilibrium Soft Matter 2010 International Symposium on Non-Equilibrium Soft Matter 2010

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Kawakatsu, T.; Matsuyama, A.; Ohta, T.; Tanaka, H.; Tanaka, S.

2011-07-01

, Culture, Sports, Science and Technology (MEXT) of Japan. We thank those who contributed to this symposium as well as members of the 'Soft Matter Physics' project for their valuable discussions and collaborations. Non-equilibrium soft matter contents Insights on raft behavior from minimal phenomenological models G Garbès Putzel and M Schick Dynamical membrane curvature instability controlled by intermonolayer friction Anne-Florence Bitbol, Jean-Baptiste Fournier, Miglena I Angelova and Nicolas Puff Numerical investigations of the dynamics of two-component vesicles Takashi Taniguchi, Miho Yanagisawa and Masayuki Imai Asymmetric distribution of cone-shaped lipids in a highly curved bilayer revealed by a small angle neutron scattering technique Y Sakuma, N Urakami, T Taniguchi and M Imai Hydration, phase separation and nonlinear rheology of temperature-sensitive water-soluble polymers Fumihiko Tanaka, Tsuyoshi Koga, Isamu Kaneda and Françoise M Winnik Morphology and rheology of an immiscible polymer blend subjected to a step electric field under shear flow H Orihara, Y Nishimoto, K Aida, Y H Na, T Nagaya and S Ujiie Surfactant-induced friction reduction for hydrogels in the boundary lubrication regime Kosuke Kamada, Hidemitsu Furukawa, Takayuki Kurokawa, Tomohiro Tada, Taiki Tominaga, Yukihiro Nakano and Jian Ping Gong Fabrication and structural analysis of polyrotaxane fibers and films Yasuhiro Sakai, Kentaro Ueda, Naoya Katsuyama, Koji Shimizu, Shunya Sato, Jun Kuroiwa, Jun Araki, Akira Teramoto, Koji Abe, Hideaki Yokoyama and Kohzo Ito Micellization kinetics of diblock copolymers in a homopolymer matrix: a self-consistent field study Raghuram Thiagarajan and David C Morse Hierarchical self-assembly of two-length-scale multiblock copolymers Gerrit ten Brinke, Katja Loos, Ivana Vukovic and Gerrit Gobius du Sart Kaleidoscopic morphologies from ABC star-shaped terpolymers Yushu Matsushita, Kenichi Hayashida, Tomonari Dotera and Atsushi Takano Direct and inverted nematic

PREFACE: The 16th International Symposium on Boron, Borides and Related Materials (ISBB 2008)

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Tanaka, Takaho

2009-07-01

supported by Tokyo University of Science, Suwa and foundations including, the Kajima Foundation, Foundation for Promotion of Material Science and Technology of Japan and Nippon Sheet Glass Foundation for Materials Science and Engineering, as well as companies including JFE Steel Corporation, Shincron Co, Ltd, Toyo Kohan Co, Ltd, Fukuda Metal Foil and Powder Co, Ltd, Japan New Metals Co, Ltd, H C Starck Ltd and Fritsch Japan Co, Ltd. Editors Chair Takaho Tanaka (National Institute for Materials Science, Japan) Vice chairs Koun Shirai (Osaka University, Japan) Kaoru Kimura (The University of Tokyo, Japan) Ken-ichi Takagi (Tokyo City University, Japan) Touetsu Shishido (Tohoku University, Japan) Shigeru Okada (Kokushikan University) Hideaki Itoh (Nagoya University,Japan) Katsumitsu Nakamura (Nihon University, Japan) Organizing committee of ISBB 2008 K Takagi Chairman (Tokyo City University) T Tanaka Program Committee Chairman (National Institute for Materials Science) K Kimura Secretary (The University of Tokyo) J Akimitsu (Aoyama University)K Shirai (Osaka University) H Itoh (Nagoya University)T Shishido (Tohoku University) K Nakamura (Nihon University)K Soga (Tokyo University of Science) K Nishiyama (Tokyo University of Science, Suwa)M Takeda (Nagaoka University of Technology) S Okada (Kokushikan University)Y Yamazaki (Toyo Kohan Co, Ltd) International Scientific Committee 0f ISBB (2008-2011) K Takagi Chairman (Japan) B Albert (Germany) J-F Halet (France) M Takeda (Japan) M Antadze (Georgia) H Hillebrecht (Germany) T Tanaka (Japan) J Bauer (France) W Jung (Germany) R Telle (Germany) I Boustani (Germany) K Kimura (Japan) M Trenary (USA) D Emin (USA) T Mori (Japan) O Tsagareishvili (Georgia) M Engler (Germany) P D Ownby (USA) H Werheit (Germany) N Frage (Israel) P Rogl (Austria) G Will (Germany) Yu Grin (Germany) S Shalamberidze (Georgia) O Yucel (Turkey) V N Gurin (Russia) N Shitsevalova (Ukraine) G Zhang (China)

PREFACE: Preface

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Luo, Qingming; Wang, Lihong V.; Tuchin, Valery V.

2011-02-01

)Ruey-Jen Sung, Stanford University (USA)A Dean Sherry, The University of Texas at Dallas (USA)Bruce Tromberg, University of California/Irvine (USA)Fujia Yang, Nottingham University (UK)Jianquan Yao, Tianjin University (China)Yixin Zeng, Sun Yat-sen University Cancer Center (China)Baoyong Zheng, Hua Wei Technologies Corporation, Inc (China) Program CommitteeWei R Chen, University of Central Oklahoma (USA)Zhongping Chen, University of California/Irvine (USA)Arthur Chiou, National Yang-Ming University (Taiwan, China)Frank Y S Chuang, University of California, Davis (USA)Zhihua Ding, Zhejiang University (China)Congwu Du, Brookhaven National Laboratory (USA)Stefan Haacke, Strasbourg University - IPCMS-DON (France)Weiping Han, Agency for Science, Technology and Research (A*STAR) (Singapore)Zheng Huang, University of Colorado Health Sciences Center (USA)Zhiwei Huang, National University of Singapore (Singapore)Steven L Jacques, Oregon Health & Science University (USA)Fu-Jen Kao, National Yang-Ming University (Taiwan, China)Hideaki Koizumi, Hitachi, Ltd (Japan)Xingde Li, Johns Hopkins University (USA)Yong-qing Li, East Carolina University (USA)Chengyi Liu, South China Normal University (China)Hong Liu, University of Oklahoma (USA)Zuhong Lu, Southeast University (China)Dennis L Matthews, University of California/Davis (USA)Avraham Mayevsky, Bar Ilan University (Israel)Stephen P Morgan, University of Nottingham (UK)Shoko Nioka, University of Pennsylvania (USA)Yingtian Pan, State University of New York at Stony Brook (USA)Alexander V Priezzhev, MV Lomonosov Moscow State University (Russia)Jianan Y Qu, The Hongkong University of Science and Technology (Hong Kong, China)Colin J R Sheppard, National University of Singapore (Singapore)Mamoru Tamura, Tsinghua University (China)Sergey Ulyanov, Saratov State University (Russia)Ruikang K Wang, Oregon Health & Science University (USA)Xunbin Wei, Fudan University (China)Da Xing, South China Normal University (China)Haishan Zeng, BC Cancer Research

Low Energy Electrons as Probing Tool for Astrochemical Reaction Mechanisms

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Hendrik Bredehöft, Jan; Swiderek, Petra; Hamann, Thorben

. Faraday Discuss., 133 (2006), 393-401 [7] Snow T.P. and Bierbaum V.M.: Ion chemistry in the interstellar medium. Ann. Rev. Analyt. Chem. 1 (2008), 229-259. [8] Nuevo M., Meierhenrich U.J., Muñoz Caro G.M., Dartois E., d'Hendecourt L., Deboffle D., n Auger G., Blanot D., Bredehüft J.H. and Nahon L.: The effects of circularly polarized light on amino acid enantiomers produced by the UV irradiation of interstellar ice analogs. AA 457 (2006), 741-751 [9] Shimamura I and Takayanagi K. (eds): Electron-Molecule Collisions. Plenum Press, New York, USA (1984) [10] Hamann T., Bühler E., Swiderek P.: Low-energy-electron-induced hydroamination of an alkene. Angew Chem Int Ed Engl. 48(25) (2009), 4643-4645.

PREFACE: Liquid-solid interfaces: structure and dynamics from spectroscopy and simulations Liquid-solid interfaces: structure and dynamics from spectroscopy and simulations

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Gaigeot, Marie-Pierre; Sulpizi, Marialore

2012-03-01

Ishiyama, Hideaki Takahashi and Akihiro Morita A theoretical study of the sum frequency vibrational spectroscopy of the carbon tetrachloride/water interface Anthony J Green, Angela Perry, Preston B Moore and Brian Space Salt effects on water/hydrophobic liquid interfaces: a molecular dynamics study Chao Zhang and Paolo Carloni Density functional theory-based simulations of sum frequency generation spectra involving methyl stretching vibrations: effect of the molecular model on the deduced molecular orientation and comparison with an analytical approach F Cecchet, D Lis, Y Caudano, A A Mani, A Peremans, B Champagne and J Guthmuller Towards modelling the vibrational signatures of functionalized surfaces: carboxylic acids on H-Si(111) surfaces Conrard Giresse Tetsassi Feugmo, Benoît Champagne, Yves Caudano, Francesca Cecchet, Yves J Chabal and Vincent Liégeois

Proceedings of the 9th International Symposium on Foundations of Quantum Mechanics in the Light of New Technology

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Ishioka, Sachio; Fujikawa, Kazuo

2009-06-01

phenomena. Dynamical magnetoelectric effects in multiferroics / Y. Tokura. Exchange-stabilization of spin accumulation in the two-dimensional electron gas with Rashba-type of spin-orbit interaction / H. M. Saarikoski, G. E. W. Bauer. Electronic Aharonov-Casher effect in InGaAs ring arrays / J. Nitta, M. Kohda, T. Bergsten. Microscopic theory of current-spin interaction in ferromagnets / H. Kohno ... [et al.]. Spin-polarized carrier injection effect in ferromagnetic semiconductor / diffusive semiconductor / superconductor junctions / H. Takayanagi ... [et al.]. Low voltage control of ferromagnetism in a semiconductor P-N junction / J. Wunderlich ... [et al.].Measurement of nanosecond-scale spin-transfer torque magnetization switching / K. Ito ... [et al.]. Current-induced domain wall creep in magnetic wires / J. Ieda, S. Maekawa, S. E. Barnes. Pure spin current injection into superconducting niobium wire / K. Ohnishi, T. Kimura, Y. Otani. Switching of a single atomic spin induced by spin injection: a model calculation / S. Kokado, K. Harigaya, A. Sakuma. Spin transfer torque in magnetic tunnel junctions with synthetic ferrimagnetic layers / M. Ichimura ... [et al.]. Gapless chirality excitations in one-dimensional spin-1/2 frustrated magnets / S. Furukawa ... [et al.] -- Dirac fermions in condensed matter. Electronic states of graphene and its multi-layers / T. Ando, M. Koshino. Inter-layer magnetoresistance in multilayer massless dirac fermions system [symbol]-(BEDT-TTF)[symbol]I[symbol] / N. Tajima ... [et al.]. Theory on electronic properties of gapless states in molecular solids [symbol]-(BEDT-TTF)[symbol]I[symbol] / A. Kobayashi, Y. Suzumura, H. Fukuyama. Hall effect and diamagnetism of bismuth / Y. Fuseya, M. Ogata, H. Fukuyama. Quantum Nernst effect in a bismuth single crystal / M. Matsuo ... [et al.] -- Quantum dot systems. Kondo effect and superconductivity in single InAs quantum dots contacted with superconducting leads / S. Tarucha ... [et al.]. Electron transport

Realizing Controllable Quantum States

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Takayanagi, Hideaki; Nitta, Junsaku

-T[stmbol] superconducting thin films with special arrangements of antidots / R. Wöerdenweber, P. Dymashevski and V. R. Misko. Quantum tunneling of relativistic fluxons / K. Konno et al. -- 6. Quantum information processing in solid states. Qubit decoherence by low-frequency noise / K. Rabenstein, V. A. Sverdlov and D. V. Averin. A critique of two-level approximation / K. Savran and T. Hakioǧlu. Josephson arrays as quantum channels / A. Romito, C. Bruder and R. Fazio. Fighting decoherence in a Josephson qubit circuit / E. Collin et al. Fast switching current detection at low critical currents / J. Walter, S. Corlevi and D. Haviland. Asymmetric flux bias for coupled qubits to observe entangled states / Y. Shimazu. Interaction of Josephson qubits with strong QED cavity modes: dynamical entanglement transfer and navigation / G. Falci et al. Controlling decoherence of transported quantum spin information in semiconductor spintronics / B. Nikolic and S. Souma. Decoherence due to telegraph and 1/f noise in Josephson qubits / E. Paladino et al. Detection of entanglement in NMR quantum information processing / R. Rahimi, K. Takeda and M. Kitagawa. Multiphoton absorption and SQUID switching current behaviors in superconducting flux-qubit experiments / H. Takayanagi et al. -- 7. Quantum information theory. Quantum query complexities / K. Iwama. A construction for non-stabilizer Clifford codes / M. Hagiwara and H. Imai. Quantum pushdown automata that can deterministically solve a certain problem / Y. Murakami et al. Trading classical for quantum computation using indirection / R. van Meter. Intractability of the initial arrangement of input data on qubits / Y. Kawano et al. Reversibility of modular squaring / N. Kunihiro, Y. Takahashi and Y. Kawano. Study of proximity effect at D-wave superconductors in quasiclassical methods / Y. Tanuma, Y. Tanaka and S. Kashiwaya -- 8. Spintronics in band electrons. Triplet superconductors: exploitable basis for scalable quantum computing / K. S. Wood et al. Spin

[Development of antituberculous drugs: current status and future prospects].

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Tomioka, Haruaki; Namba, Kenji

2006-12-01

national project in US started last year, Reverse Proteomics Research Institute Co., Ltd. (REPRORI) has developed the core technologies for chemical genomics. Here we describe the outline of chemical genomics study, especially that of REPRORI, and discuss about its possible application to the development of anti-tuberculosis drugs. 3. Anti-mycobacterial agents and drug delivery: Koichi IZUMIKAWA, Hideaki OHNO, Shigeru KOHNO (Second Department of Internal Medicine, Nagasaki University School of Medicine) Mycobacterium infection is a major clinical concern in whole world. Since the newly developed anti-mycobacterial agents are few and still unavailable in clinical settings, the applications of drug delivery system using conventional anti-mycobacterial agents are challenging to improve the compliance of treatment and better efficacy. The efficacy of anti-mycobacterial agents modified by liposome or polymer based technology have been investigated and reported using various animal models. Drug delivery system increased and prolonged the drug concentrations at the blood and targeted organs and the duration of sustained drug release, respectively. These effects lead to decrease in the frequency of drug administrations dramatically and better efficacy rates. The studies, however, were performed only in animal models, the further investigations and evaluations in human are required for practical use. 4. Adjunctive immunotherapy of mycobacterial infections: Toshiaki SHIMIZU, Katsumasa SATO, Haruaki TOMIOKA (Department of Microbiology and Immunology, Shimane University School of Medicine) There is an urgent need to develop new antimicrobials and protocols for the administration of drugs that are potently efficacious against intractable mycobacterial infections. Unfortunately, development of the new drugs for solving this problem is not progressing. (ABSTRACT TRUNCATED)

[Tuberculosis in compromised hosts].

Science.gov (United States)

2003-11-01

treatment is delayed, it is fatally because hematogenous metastasis are easy to occur and become miliary tuberculosis. 4. AIDS and tuberculosis: Hideaki NAGAI (Department of Respiratory Diseases, National Tokyo Hospital). With AIDS patients with tuberculosis, there are the following problems on the treatment. (1) The adverse reactions by antituberculosis drugs tend to occur in AIDS patients. Eleven of 33 AIDS patients with tuberculosis had the adverse reactions (skin rash, fever, liver dysfunction) considered to be due to antituberculosis drugs. It is a very large burden for the HIV infected persons to take simultaneously antituberculosis drugs, medicines for opportunistic infections, and anti-HIV medicines. Since many medicines are taken, it is difficult to determine which drug is the cause once an adverse reaction occurs and all medicines should be often stopped. (2) The combined use with rifampicin (RFP) is difficult for the protease inhibitors and nonnuclear acid reverse transcriptase inhibitors. RFP induces cytochrome P-450 in liver, accelerates the metabolism of some concomitant drug agents, and reduces blood concentration them remarkably. When starting the two above-mentioned medicines during tuberculosis treatment, RFP should be changed to rifabutin (RFB) which has less induction of P-450 than RFP. However, some procedures are required for acquisition of RFB and it is a little complicated in Japan. CDC mentioned the combined use with RFP and efavirenz (EFV) is possible. So, the treatment with EFV and RFP is recently chosen. However, the monitor of the blood concentration of EFV is required, and the dose of EFV should be increased if it is a low value. (3) When a highly active antiretroviral therapy (HAART) is given to AIDS patients with tuberculosis, transient worsening of tuberculosis may develop after about two weeks. (ABSTRACT TRUNCATED)