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Sample records for hhs acquisition regulation

  1. 42 CFR 59a.17 - Other HHS regulations that apply.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations that apply. 59a.17 Section 59a.17 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Establishment of Regional Medical Libraries § 59a.17 Other HHS regulations that...

  2. 45 CFR 1.1 - Location of HHS regulations.

    Science.gov (United States)

    2010-10-01

    ... located at Parts 1-1299 of Title 21. • Procurement (contract) regulations are located at Chapter 3 of Title 41. Each volume of the Code contains an index of its parts. (5 U.S.C. 301) ... titles of the Code of Federal Regulations: • Regulations having HHS-wide application or which the...

  3. 42 CFR 66.112 - Other HHS regulations and policies that apply.

    Science.gov (United States)

    2010-10-01

    ... is subject to change, and interested persons should contact the Office of Science Policy, Office of... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations and policies that apply. 66... regulations and policies that apply. Several other regulations and policies may apply to individuals and...

  4. 42 CFR 63.10 - Other HHS regulations and policies that apply.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Other HHS regulations and policies that apply. 63.10 Section 63.10 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES... number) to obtain copies of the policy.) “Public Health Service Policy on Humane Care and Use...

  5. 42 CFR 65a.11 - Other HHS regulations and policies that apply.

    Science.gov (United States)

    2010-10-01

    ... research for which PHS funding is sought 42 CFR part 52h—Scientific peer review of research grant... on Humane Care and Use of Laboratory animals,” Office for Protection from Research Risks, HIH... BASIC RESEARCH AND TRAINING GRANTS § 65a.11 Other HHS regulations and policies that apply. Several...

  6. 75 FR 57690 - Acquisition Regulation: Sustainable Acquisition

    Science.gov (United States)

    2010-09-22

    ... Parts 907, 923, 936, 952, and 970 RIN 1991-AB95 Acquisition Regulation: Sustainable Acquisition AGENCY... (DOE) is amending the Department of Energy Acquisition Regulation (DEAR) to implement Executive Order... to leverage agency acquisitions to foster markets for sustainable technologies and energy...

  7. 48 CFR 307.104-70 - Acquisition strategy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Acquisition strategy. 307... AND ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Planning 307.104-70 Acquisition strategy... designated by the HHS CIO, DASFMP, the CAO, or the cognizant HCA) shall prepare an acquisition strategy...

  8. 78 FR 35195 - Acquisition Regulations: Export Control

    Science.gov (United States)

    2013-06-12

    ... Parts 925, 952, and 970 RIN 1991-AB99 Acquisition Regulations: Export Control AGENCY: Department of... amend the Department of Energy Acquisition Regulation (DEAR) to add export control requirements... ``DEAR: Export Control and RIN 1991-AB99,'' by any of the following methods: Federal eRulemaking Portal...

  9. 78 FR 45168 - Acquisition Regulations: Export Control

    Science.gov (United States)

    2013-07-26

    ... Parts 925, 952 and 970 RIN 1991-AB99 Acquisition Regulations: Export Control AGENCY: Department of... Department of Energy Acquisition Regulation (DEAR) to add export control requirements applicable to the... business August 23, 2013. ADDRESSES: You may submit comments, identified by ``DEAR: Export Control and RIN...

  10. 77 FR 181 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-55; Introduction

    Science.gov (United States)

    2012-01-03

    ... Space Administration 48 CFR Chapter 1 Federal Acquisition Regulation; Final Rules #0;#0;Federal Register... Acquisition Regulation; Federal Acquisition Circular 2005-55; Introduction AGENCIES: Department of Defense (Do... Acquisition Regulation (FAR) rules agreed to by DoD, GSA, and NASA in this Federal Acquisition Circular...

  11. 76 FR 30362 - Federal Acquisition Regulation; Submission for OMB Review; Acquisition of Helium

    Science.gov (United States)

    2011-05-25

    ... ADMINISTRATION [OMB Control No. 9000-0113; Docket 2011-0079; Sequence 5] Federal Acquisition Regulation; Submission for OMB Review; Acquisition of Helium AGENCY: Department of Defense (DOD), General Services... approved information collection requirement concerning acquisition of helium. Public comments...

  12. 78 FR 80367 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-72; Introduction

    Science.gov (United States)

    2013-12-31

    ...This document summarizes the Federal Acquisition Regulation (FAR) rules agreed to by the Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) in this Federal Acquisition Circular (FAC) 2005-72. A companion document, the Small Entity Compliance Guide (SECG), follows this FAC. The FAC, including the SECG, is available via the Internet at......

  13. 76 FR 11985 - Acquisition Regulation: Department of Energy Acquisition Regulation, Government Property

    Science.gov (United States)

    2011-03-04

    ... Regulation, Government Property AGENCY: Department of Energy. ACTION: Notice of proposed rulemaking. SUMMARY... (DEAR) to conform to the Federal Acquisition Regulation (FAR), remove out-of date government property..., Government Property, and related 970, Management and Operating Contracts, to remove out-of-date coverage, to...

  14. 76 FR 12357 - Federal Acquisition Regulation; Information Collection; Acquisition of Helium

    Science.gov (United States)

    2011-03-07

    ...; Docket 2011-0079; Sequence 5] Federal Acquisition Regulation; Information Collection; Acquisition of... requirement concerning acquisition of helium. Public comments are particularly invited on: Whether this... cite OMB Control No. 9000-0113, Acquisition of Helium, in all correspondence. Dated: February 24,...

  15. Shigella Iron Acquisition Systems and their Regulation.

    Science.gov (United States)

    Wei, Yahan; Murphy, Erin R

    2016-01-01

    Survival of Shigella within the host is strictly dependent on the ability of the pathogen to acquire essential nutrients, such as iron. As an innate immune defense against invading pathogens, the level of bio-available iron within the human host is maintained at exceeding low levels, by sequestration of the element within heme and other host iron-binding compounds. In response to sequestration mediated iron limitation, Shigella produce multiple iron-uptake systems that each function to facilitate the utilization of a specific host-associated source of nutrient iron. As a mechanism to balance the essential need for iron and the toxicity of the element when in excess, the production of bacterial iron acquisition systems is tightly regulated by a variety of molecular mechanisms. This review summarizes the current state of knowledge on the iron-uptake systems produced by Shigella species, their distribution within the genus, and the molecular mechanisms that regulate their production.

  16. 77 FR 74382 - Acquisition Regulation: Department of Energy Acquisition Regulation, Government Property

    Science.gov (United States)

    2012-12-14

    ... Management Regulation 41 CFR 102-36.220, shall be reported for centralized screening in the DOE Energy Asset..., subcompact, and compact vehicles which meet Government fuel economy standards. The acquisition of light trucks is limited to those vehicles which meet the current fuel economy standards set by Executive Orders...

  17. 78 FR 56706 - HHS Retrospective Review 2013 Request for Information

    Science.gov (United States)

    2013-09-13

    ... administration burdens; Achieve better results by modifying, streamlining, expanding, or eliminating rules when the costs or benefits are greater than originally anticipated; Eliminate rules that are outdated... existing regulations HHS should consider reviewing in order to streamline or eliminate...

  18. 76 FR 31393 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-52; Introduction

    Science.gov (United States)

    2011-05-31

    ... implement Executive Order 13514, Federal Leadership in Environmental, Energy, and Economic Performance, and... specified, all Federal Acquisition Regulation (FAR) ] and other directive material contained in FAC...

  19. 78 FR 13544 - Defense Federal Acquisition Regulation Supplement: Acquisition of Tents and Other Temporary...

    Science.gov (United States)

    2013-02-28

    ... Acquisition Regulation Supplement: Acquisition of Tents and Other Temporary Structures (DFARS Case 2012-D015... the National Defense Authorization Act for Fiscal Year 2012 that address the acquisition of tents and... contracts that provide the best value, when acquiring tents and other temporary structures, regardless...

  20. 75 FR 8272 - Defense Federal Acquisition Regulation Supplement; Acquisition Strategies To Ensure Competition...

    Science.gov (United States)

    2010-02-24

    ... Regulation Supplement; Acquisition Strategies To Ensure Competition Throughout the Life Cycle of Major... Reform Act of 2009, section 202, Acquisition Strategies to Ensure Competition throughout the Lifecycle of... requirements. Section 202 directs the Secretary of Defense (SECDEF) to ensure that the acquisition strategy...

  1. 75 FR 10567 - Commerce Acquisition Regulation (CAR)

    Science.gov (United States)

    2010-03-08

    ... acquisitions, research and development contracting, security processing, value engineering, and termination of..., Terms. 48 CFR Part 1303 Antitrust, Conflict of interests, Ethical conduct, Government procurement... Affirmative procurement program, Air pollution control, Drug abuse, Drug-free workplace, Energy conservation...

  2. 77 FR 38734 - Defense Federal Acquisition Regulation Supplement; Acquisition of Tents and Other Temporary...

    Science.gov (United States)

    2012-06-29

    ... Regulation Supplement; Acquisition of Tents and Other Temporary Structures (DFARS Case 2012-D015) AGENCY... 2012 that address the acquisition of tents and other temporary structures. DATES: Effective date: June... the best value, when acquiring tents and other temporary structures, regardless of whether...

  3. 77 FR 30365 - Defense Federal Acquisition Regulation Supplement: Report on Waiver of Prohibition on Acquisition...

    Science.gov (United States)

    2012-05-22

    ... Regulation Supplement: Report on Waiver of Prohibition on Acquisition From Communist Chinese Military... prohibition on acquisition of United States Munitions List items from Communist Chinese military companies... Chinese military companies. The prior requirement was for a report within 30 days after the date of the...

  4. 78 FR 80381 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-72; Small Entity Compliance Guide

    Science.gov (United States)

    2013-12-31

    ...This document is issued under the joint authority of DOD, GSA, and NASA. This Small Entity Compliance Guide has been prepared in accordance with section 212 of the Small Business Regulatory Enforcement Fairness Act of 1996. It consists of a summary of the rules appearing in Federal Acquisition Circular (FAC) 2005-72, which amends the Federal Acquisition Regulation (FAR). An asterisk (*) next......

  5. 76 FR 50461 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Types of...

    Science.gov (United States)

    2011-08-15

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Types of Contracts AGENCY: Defense Acquisition Regulations System, Department of... information collection requirement. SUMMARY: In compliance with Section 3506(c)(2)(A) of the...

  6. 76 FR 12795 - Department of Education Acquisition Regulation

    Science.gov (United States)

    2011-03-08

    ... Register (75 FR 51884) to reissue the Department of Education Acquisition Regulation (EDAR). In the... Activity. IPv6--Internet Protocol version 6. OMB--Office of Management and Budget. OSDBU--Office of...

  7. 77 FR 14480 - Defense Federal Acquisition Regulation Supplement: Commercial Determination Approval (DFARS Case...

    Science.gov (United States)

    2012-03-12

    ... acquisitions made pursuant to Federal Acquisition Regulation (FAR) 12.102(f)(1).'' This language clarifies that... Defense Acquisition Regulations System 48 CFR Part 212 RIN 0750-AH61 Defense Federal Acquisition Regulation Supplement: Commercial Determination Approval (DFARS Case 2011-D041) AGENCY: Defense Acquisition...

  8. 76 FR 44293 - Defense Acquisition Regulations System; Defense Federal Acquisition Regulation Supplement; Only...

    Science.gov (United States)

    2011-07-25

    ... presented by the Under Secretary of Defense for Acquisition, Technology, & Logistics in a memorandum dated... offered price. These provisions must also be used in acquisitions of commercial items conducted using part...--ACQUISITION OF COMMERCIAL ITEMS 4. Add new section 212.205 to read as follows: 212.205 Offers. (c) When...

  9. 78 FR 26518 - Federal Acquisition Regulation; Government Property

    Science.gov (United States)

    2013-05-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 52 Federal Acquisition Regulation; Government Property CFR Correction In Title 48 of the Code of Federal Regulations...

  10. 76 FR 11985 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Science.gov (United States)

    2011-03-04

    ... Acquisition Regulation Supplement; Reporting of Government-Furnished Property AGENCY: Defense Acquisition... expand reporting requirements for Government-furnished property to include items uniquely and non...

  11. 76 FR 68040 - Federal Acquisition Regulation; Labor Relations Costs

    Science.gov (United States)

    2011-11-02

    ... careful review of public comments, discussed below, DoD, GSA, and NASA have concluded that the proposed... Federal Acquisition Regulation; Labor Relations Costs AGENCY: Department of Defense (DoD), General....205-21, the cost principle addressing labor relations costs. Currently, this cost principle states...

  12. 77 FR 12930 - Federal Acquisition Regulation: Socioeconomic Program Parity

    Science.gov (United States)

    2012-03-02

    ... (SDVOSB) Program, or the Women-Owned Small Business (WOSB) Program. DATES: Effective Date: April 2, 2012...-Disabled Veteran-Owned Small Business (SDVOSB) Program (see subpart 19.14); or (iv) Women-Owned Small... amending the Federal Acquisition Regulation (FAR) to implement a section of the Small Business Jobs Act...

  13. 75 FR 14496 - Commerce Acquisition Regulation (CAR); Correction

    Science.gov (United States)

    2010-03-26

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF COMMERCE 48 CFR Part 1352 RIN 0605-AA26 Commerce Acquisition Regulation (CAR); Correction AGENCY: Department of Commerce (DOC). ACTION: Final rule; correction. SUMMARY: We, the Department of Commerce, issue a final...

  14. 78 FR 37690 - Federal Acquisition Regulation; Price Analysis Techniques

    Science.gov (United States)

    2013-06-21

    ... Federal Acquisition Regulation; Price Analysis Techniques AGENCY: Department of Defense (DoD), General... clarify and give a precise reference in the use of a price analysis technique in order to establish a fair... reference used in FAR 15.404-1(b)(2)(i). FAR 15.404-1(b)(2) addresses various price analysis techniques and...

  15. 77 FR 40552 - Federal Acquisition Regulation; Price Analysis Techniques

    Science.gov (United States)

    2012-07-10

    ... Federal Acquisition Regulation; Price Analysis Techniques AGENCY: Department of Defense (DoD), General... clarify the use of a price analysis technique in order to establish a fair and reasonable price. DATES....404-1(b)(2) addresses various price analysis techniques and procedures the Government may use to...

  16. 77 FR 189 - Federal Acquisition Regulation; Brand-Name Specifications

    Science.gov (United States)

    2012-01-03

    ...-AK55 Federal Acquisition Regulation; Brand-Name Specifications AGENCIES: Department of Defense (DoD... brand-name specifications. DATES: Effective Date: February 2, 2012. FOR FURTHER INFORMATION CONTACT: Mr... of Management and Budget (OMB) memoranda and policies on the use of brand- name specifications....

  17. 78 FR 48123 - Federal Acquisition Regulation; Contractor Comment Period, Past Performance Evaluations

    Science.gov (United States)

    2013-08-07

    ... Federal Acquisition Regulation; Contractor Comment Period, Past Performance Evaluations AGENCY: Department... comments on past performance evaluations and making past performance evaluations available to source... Decisions'', require revisions to the acquisition regulations on past performance evaluations so...

  18. 76 FR 8989 - Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References

    Science.gov (United States)

    2011-02-16

    ... 9000-AM00 Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting... to amend the Federal Acquisition Regulation (FAR) to update references to authoritative accounting standards owing to the Financial Accounting Standards Board's (FASB's) Accounting Standards...

  19. 75 FR 71647 - Defense Federal Acquisition Regulation Supplement; Discussions Prior to Contract Award (DFARS...

    Science.gov (United States)

    2010-11-24

    ... Defense Acquisition Regulations System 48 CFR Part 215 Defense Federal Acquisition Regulation Supplement... amend the Defense Federal Acquisition Regulation Supplement (DFARS) to strongly encourage discussions... requirements. DoD notes the potential disadvantages of this proposed change in increased time to complete...

  20. 76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Rules of the Armed Services Board of Contract...

    Science.gov (United States)

    2011-05-11

    ... Defense Acquisition Regulations System 48 CFR Chapter 2 Defense Federal Acquisition Regulation Supplement; Rules of the Armed Services Board of Contract Appeals AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is issuing a final rule to update the Rules...

  1. 75 FR 32635 - Defense Acquisition Regulations System; Defense Federal Acquisition Regulation Supplement...

    Science.gov (United States)

    2010-06-08

    ... Regulation Supplement; Balance of Payments Program Exemption for Commercial Information Technology... implement in the clauses at 252.225-7044, Balance of Payments Program--Construction Material, and 252.225-7045, Balance of Payments Program--Construction Material under Trade Agreements, the exemption from...

  2. Iron acquisition and regulation systems in Streptococcus species.

    Science.gov (United States)

    Ge, Ruiguang; Sun, Xuesong

    2014-05-01

    Gram-positive Streptococcus species are responsible for millions of cases of meningitis, bacterial pneumonia, endocarditis, erysipelas and necrotizing fasciitis. Iron is essential for the growth and survival of Streptococcus in the host environment. Streptococcus species have developed various mechanisms to uptake iron from an environment with limited available iron. Streptococcus can directly extract iron from host iron-containing proteins such as ferritin, transferrin, lactoferrin and hemoproteins, or indirectly by relying on the employment of specialized secreted hemophores (heme chelators) and small siderophore molecules (high affinity ferric chelators). This review presents the most recent discoveries in the iron acquisition system of Streptococcus species - the transporters as well as the regulators.

  3. 76 FR 11411 - Defense Federal Acquisition Regulation Supplement; Multiyear Contracting (DFARS Case 2009-D026)

    Science.gov (United States)

    2011-03-02

    ... aircrew members or foreign language training); (4) Base services (e.g., ground maintenance, in-plane... Defense Acquisition Regulations System 48 CFR Part 217 RIN 0750-AG89 Defense Federal Acquisition Regulation Supplement; Multiyear Contracting (DFARS Case 2009-D026) AGENCY: Defense Acquisition...

  4. 75 FR 48276 - Defense Federal Acquisition Regulation Supplement; Management of Unpriced Change Orders

    Science.gov (United States)

    2010-08-10

    ... Acquisition Regulation Supplement; Management of Unpriced Change Orders AGENCY: Defense Acquisition... management and oversight of unpriced change orders consistent with those that apply to other undefinitized.... * * * * * (c) Consolidated UCA Management Reports shall include information about all change orders that are...

  5. 77 FR 5714 - Office of Procurement and Property Management; Agriculture Acquisition Regulation, Labor Law...

    Science.gov (United States)

    2012-02-06

    ... Regulation, Labor Law Violations; Withdrawal AGENCY: Office of Procurement and Property Management... new clause to the Agriculture Acquisition Regulation at subpart 422.70 entitled ``Labor Law Violations... published on December 1, 2011 (76 FR 74722), entitled ``Agriculture Acquisition Regulation, Labor...

  6. 75 FR 60263 - Federal Acquisition Regulation; Offering a Construction Requirement-8(a) Program

    Science.gov (United States)

    2010-09-29

    ... Federal Acquisition Regulation; Offering a Construction Requirement--8(a) Program AGENCIES: Department of... Regulations Council (Councils) are issuing a final rule amending the Federal Acquisition Regulation (FAR) to revise FAR subpart 19.8, Contracting with the Small Business Administration (The 8(a) Program),...

  7. 75 FR 65439 - Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting System

    Science.gov (United States)

    2010-10-25

    ...-602-0350. Mail: Defense Acquisition Regulations System, Attn: Ms. Cassandra R. Freeman, OUSD (AT&L... be posted to http://www.regulations.gov . FOR FURTHER INFORMATION CONTACT: Ms. Cassandra R. Freeman... procurement. Clare M. Zebrowski, Editor, Defense Acquisition Regulations System. 0 Therefore, 48 CFR parts 219...

  8. 75 FR 20825 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot...

    Science.gov (United States)

    2010-04-21

    ... Regulation Supplement; DoD Pilot Mentor-Protege Program AGENCY: Defense Acquisition Regulations System... Acquisition Regulation Supplement (DFARS) Appendix I, DoD Pilot Mentor-Protege Program; OMB Control Number... Mentor-Protege Program have been met. The purposes of the Program are to (1) provide incentives to...

  9. 77 FR 14016 - General Services Administration Acquisition Regulation; Preparation, Submission, and Negotiation...

    Science.gov (United States)

    2012-03-08

    ...] General Services Administration Acquisition Regulation; Preparation, Submission, and Negotiation of... Negotiation of Subcontracting Plans; Correction. Correction In the information collection document...

  10. 75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-09

    ... Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration (DFARS Case... INFORMATION: I. Background DoD published a proposed rule for Business Systems--Definition and...

  11. 77 FR 19975 - VA Acquisition Regulation: Simplified Acquisition Procedures for Health-Care Resources (Section...

    Science.gov (United States)

    2012-04-03

    ... acquisition of health-care resources, consisting of commercial services or the use of medical equipment or... Service (003A2A), Office of Acquisition, Logistics and Construction, Department of Veterans Affairs, 810... rule only applies to competitive acquisitions of commercial services or the use of medical equipment...

  12. 77 FR 5750 - Office of Procurement and Property Management; Agriculture Acquisition Regulation, Labor Law...

    Science.gov (United States)

    2012-02-06

    ... Regulation, Labor Law Violations; Withdrawal AGENCY: Office of Procurement and Property Management... subpart 422.70 entitled ``Labor Law Violations'' that would have a contractor certify upon accepting a...), entitled ``Office of Procurement and Property Management, Agriculture Acquisition Regulation, Labor...

  13. 77 FR 27548 - Federal Acquisition Regulation; Free Trade Agreement-Colombia

    Science.gov (United States)

    2012-05-10

    ... 9000-AM24 Federal Acquisition Regulation; Free Trade Agreement--Colombia AGENCY: Department of Defense... Acquisition Regulation (FAR) to implement the United States- Colombia Trade Promotion Agreement. This Trade... eligible products and services from Colombia. DATES: Effective Date: May 15, 2012. Comment Date:...

  14. 77 FR 13952 - Federal Acquisition Regulation; United States-Korea Free Trade Agreement

    Science.gov (United States)

    2012-03-07

    ... RIN 9000-AM18 Federal Acquisition Regulation; United States-Korea Free Trade Agreement AGENCY... Federal Acquisition Regulation (FAR) to implement the United States- Korea Free Trade Agreement. The...-Korea Free Trade Agreement (see the United States-Korea Free Trade Agreement Implementation Act (Pub. L...

  15. 76 FR 75875 - Defense Federal Acquisition Regulation Supplement; Open Source Software Public Meeting

    Science.gov (United States)

    2011-12-05

    ... Defense Acquisition Regulations System Defense Federal Acquisition Regulation Supplement; Open Source... regarding the use of open source software in DoD contracts. DATES: Public Meeting: January 12, 2012, from 10... for the discussions in the meeting. Please cite ``Public Meeting, DFARS--Open Source Software'' in all...

  16. 76 FR 14562 - Federal Acquisition Regulation; Additional Requirements for Market Research

    Science.gov (United States)

    2011-03-16

    ... 52 RIN 9000-AL50 Federal Acquisition Regulation; Additional Requirements for Market Research AGENCY... interim rule amending the Federal Acquisition Regulation (FAR) to implement section 826, Market Research... items engages in market research as necessary before making purchases. DATES: Effective Date: April...

  17. 76 FR 68015 - Federal Acquisition Regulation; Notification of Employee Rights Under the National Labor...

    Science.gov (United States)

    2011-11-02

    ... activities related to the performance of the contract.'' The respondent stated that the following language at... 52 RIN 9000-AL76 Federal Acquisition Regulation; Notification of Employee Rights Under the National... adopted as final, without change, an interim rule amending the Federal Acquisition Regulation (FAR) to...

  18. 75 FR 32642 - Defense Federal Acquisition Regulation Supplement; Ground and Flight Risk Clause (DFARS Case 2007...

    Science.gov (United States)

    2010-06-08

    ... Acquisition Regulation Supplement; Ground and Flight Risk Clause (DFARS Case 2007-D009) AGENCY: Defense... final rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to revise and combine... disadvantage small businesses. Most of the small businesses participating in these contracts do so as...

  19. 76 FR 74755 - Office of Procurement and Property Management; Agriculture Acquisition Regulation, Labor Law...

    Science.gov (United States)

    2011-12-01

    ... Department of Agriculture (USDA) proposes to amend the Agriculture Acquisition Regulation (the ``AGAR'') to... Violations to the Agriculture Acquisition Regulation (AGAR). The AGAR may be accessed at: http://www.dm.usda.gov/procurement/policy/agar.html . This clause is to be included in all USDA contracts that exceed...

  20. 76 FR 38050 - Defense Federal Acquisition Regulation Supplement; Management of Manufacturing Risk in Major...

    Science.gov (United States)

    2011-06-29

    ... Regulation Supplement; Management of Manufacturing Risk in Major Defense Acquisition Programs (DFARS Case... require the approval of the Office of Management and Budget under the Paperwork Reduction Act (44 U.S.C... Government procurement. Mary Overstreet, Editor, Defense Acquisition Regulations System. Therefore, 48...

  1. Patricia Hartge Receives the HHS Career Achievement Award

    Science.gov (United States)

    In February 2012, Patricia Hartge, Sc.D., Deputy Director of DCEG’s Epidemiology and Biostatistics Program, received the Department of Health and Human Services (HHS) Career Achievement Award at the HHS Honor Awards Ceremony.

  2. 42 CFR 93.413 - HHS compliance actions.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false HHS compliance actions. 93.413 Section 93.413... Compliance Issues § 93.413 HHS compliance actions. (a) An institution's failure to comply with its assurance... requirements of this part, HHS may take some or all of the following compliance actions: (1) Issue a letter...

  3. 48 CFR 301.603-73 - Additional HHS training requirements.

    Science.gov (United States)

    2010-10-01

    ... GS-1102s and GS-1105s are required to complete both HHS University's classroom-based and on-line... entering on duty (for new employees). Employees are required to take the HHS University on-line course as.... When the HHS Office on Disability (OD) so requires, all GS-1102s, GS-1105s and GS-1106s who award...

  4. Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition

    DEFF Research Database (Denmark)

    Liu, Tao; Li, Yingjun; Wang, Xiaodi;

    2015-01-01

    , it was demonstrated that the transcription level of csa1, cas1, cas2 and cas4 was significantly enhanced in a csa3a-overexpression strain and, moreover, the Csa1 and Cas1 protein levels were increased in this strain. Furthermore, we demonstrated the hyperactive uptake of unique spacers within both CRISPR loci......Acquisition of de novo spacer sequences confers CRISPR-Cas with a memory to defend against invading genetic elements. However, the mechanism of regulation of CRISPR spacer acquisition remains unknown. Here we examine the transcriptional regulation of the conserved spacer acquisition genes in Type I...... in the presence of the csa3a overexpression vector. The spacer acquisition process is dependent on the CCN PAM sequence and protospacer selection is random and non-directional. These results suggested a regulation mechanism of CRISPR spacer acquisition where a single transcriptional regulator senses the presence...

  5. Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition

    DEFF Research Database (Denmark)

    Liu, Tao; Li, Yingjun; Wang, Xiaodi

    2015-01-01

    Acquisition of de novo spacer sequences confers CRISPR-Cas with a memory to defend against invading genetic elements. However, the mechanism of regulation of CRISPR spacer acquisition remains unknown. Here we examine the transcriptional regulation of the conserved spacer acquisition genes in Type I......, it was demonstrated that the transcription level of csa1, cas1, cas2 and cas4 was significantly enhanced in a csa3a-overexpression strain and, moreover, the Csa1 and Cas1 protein levels were increased in this strain. Furthermore, we demonstrated the hyperactive uptake of unique spacers within both CRISPR loci...... in the presence of the csa3a overexpression vector. The spacer acquisition process is dependent on the CCN PAM sequence and protospacer selection is random and non-directional. These results suggested a regulation mechanism of CRISPR spacer acquisition where a single transcriptional regulator senses the presence...

  6. 76 FR 31424 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-52; Small Entity Compliance Guide

    Science.gov (United States)

    2011-05-31

    ... GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Chapter 1 Federal... of Defense (DoD), General Services Administration (GSA), and National Aeronautics and Space..., operation and maintenance, management, and deconstruction practices in applicable acquisitions....

  7. 75 FR 1567 - Defense Federal Acquisition Regulation Supplement; Foreign Participation in Acquisitions in...

    Science.gov (United States)

    2010-01-12

    ... and South Asian (SC/CASA) states; and Determination of inapplicability of the Balance of Payments... 302(a) of the Trade Agreements Act of 1979, as amended, which prohibits acquisitions of products or...

  8. 75 FR 71560 - Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting System (DFARS...

    Science.gov (United States)

    2010-11-24

    ... is provided for contractors with accounting software that does not accommodate the additional data... Acquisition Regulation Supplement; Cost and Software Data Reporting System (DFARS Case 2008-D027) AGENCY... Cost and Software Data Reporting system requirements for Major Defense Acquisition Programs and...

  9. 77 FR 59790 - General Services Administration Acquisition Regulation (GSAR); Rewrite of Part 504...

    Science.gov (United States)

    2012-10-01

    ... (GSAR); Rewrite of Part 504; Administrative Matters AGENCY: Office of Acquisition Policy, General... Administrative Matters and Forms. This final rule is part of the General Services Administration Acquisition Manual (GSAM) rewrite Project, in which all parts of the regulation are being reviewed and updated to...

  10. 76 FR 31415 - Federal Acquisition Regulation; Buy American Exemption for Commercial Information Technology...

    Science.gov (United States)

    2011-05-31

    ... 9000-AL62 Federal Acquisition Regulation; Buy American Exemption for Commercial Information Technology... from the Buy American Act for acquisition of information technology that is a commercial item. DATES...., because the rule simplifies the treatment of construction material that is also a commercial...

  11. 75 FR 60266 - Federal Acquisition Regulation; Buy American Exemption for Commercial Information Technology...

    Science.gov (United States)

    2010-09-29

    ... Regulation; Buy American Exemption for Commercial Information Technology--Construction Material AGENCIES... Act for acquisition of information technology that is a commercial item. DATES: Effective Date... the Buy American Act for acquisition of information technology that is a commercial item. This...

  12. 76 FR 46206 - NASA Implementation of Federal Acquisition Regulation (FAR) Award Fee Language Revision

    Science.gov (United States)

    2011-08-02

    ... SPACE ADMINISTRATION 48 CFR Part 1816 RIN 2700-AD69 NASA Implementation of Federal Acquisition Regulation (FAR) Award Fee Language Revision AGENCY: National Aeronautics and Space Administration. ACTION... Supplement (NFS) to implement the FAR Award Fee revision issued in Federal Acquisition Circular (FAC) 2005-46...

  13. 75 FR 71564 - Defense Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS...

    Science.gov (United States)

    2010-11-24

    ... Regulation Supplement; Contractor Insurance/Pension Review (DFARS Case 2009-D025) AGENCY: Defense Acquisition.../Pension Review from Procedures, Guidance, and Information (PGI) to the Defense Federal Acquisition... requirements for Contractor Insurance/ Pension Review to DFARS 242.7302 from PGI 242.7302. DoD published a...

  14. 76 FR 78874 - Defense Federal Acquisition Regulation Supplement: Title 41 Positive Law Codification-Further...

    Science.gov (United States)

    2011-12-20

    ... Positive Law Codification--Further Implementation (DFARS Case 2012- D003) AGENCIES: Defense Acquisition... Defense Federal Acquisition Regulation Supplement to conform statutory titles to the new Positive Law Codification of Title 41, United States Code, ``Public Contracts.'' DATES: Comment Date: Comments on the...

  15. 75 FR 60690 - Defense Federal Acquisition Regulation Supplement (DFARS); Electronic Ordering Procedures (DFARS...

    Science.gov (United States)

    2010-10-01

    ... FAR 52.216-18, Ordering. The benefit of this rule to small business is that it will make electronic... Supplement (DFARS); Electronic Ordering Procedures (DFARS Case 2009-D037) AGENCY: Defense Acquisition... is proposing to amend the Defense Federal Acquisition Regulation Supplement to address...

  16. 75 FR 48278 - Defense Federal Acquisition Regulation Supplement; Excessive Pass-Through Charges

    Science.gov (United States)

    2010-08-10

    ... Regulation Supplement; Excessive Pass-Through Charges AGENCY: Defense Acquisition Regulations System... ensures that pass-through charges on contracts or subcontracts that are entered into for or on behalf of... required DoD to prescribe regulations to ensure that pass-through charges on contracts or subcontracts...

  17. 75 FR 13763 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1217...

    Science.gov (United States)

    2010-03-23

    ... ADMINISTRATION DEPARTMENT OF DEFENSE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1217, Lessor's Annual Cost Statement AGENCY: Department of Defense (DOD), General Services Administration (GSA), and National Aeronautics...

  18. 75 FR 4565 - General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial...

    Science.gov (United States)

    2010-01-28

    ... ADMINISTRATION General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial... reinstatement of a previously approved information collection requirement regarding industrial ] funding fee and..., Industrial Funding Fee and Sales Reporting, in all correspondence. SUPPLEMENTARY INFORMATION: A....

  19. 78 FR 27239 - General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial...

    Science.gov (United States)

    2013-05-09

    ... ADMINISTRATION General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial... previously approved information collection requirement regarding industrial funding fee and sales reporting....munson@gsa.gov . ADDRESSES: Submit comments identified by Information Collection 3090- 0121,...

  20. 76 FR 52133 - Defense Federal Acquisition Regulation Supplement; Contractors Performing Private Security...

    Science.gov (United States)

    2011-08-19

    ... Acquisition Regulation Supplement; Contractors Performing Private Security Functions (DFARS Case 2011-D023..., equipping, and conduct of personnel performing private security functions. DATES: Effective Date: August 19.... 110-181, enacted October 28, 2008), section 862, entitled ``Contractors Performing Private...

  1. 77 FR 202 - Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References

    Science.gov (United States)

    2012-01-03

    ... 9000-AM00 Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting... accounting standards owing to the Financial Accounting Standards Board's Accounting Standards Codification of Generally Accepted Accounting Principles. DATES: Effective Date: February 2, 2012. FOR FURTHER...

  2. 78 FR 41331 - Federal Acquisition Regulation; Publicizing Contract Actions; Contracting by Negotiation

    Science.gov (United States)

    2013-07-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Parts 5 and 15 Federal Acquisition Regulation; Publicizing Contract Actions; Contracting by Negotiation CFR Correction...

  3. 77 FR 3636 - Federal Acquisition Regulation; Brand-Name Specifications; Correction

    Science.gov (United States)

    2012-01-25

    ... Acquisition Regulation; Brand-Name Specifications; Correction AGENCY: Department of Defense (DoD), General... Management and Budget memoranda on brand-name specifications, FAR Case 2005-037, Brand-Name...

  4. 77 FR 5020 - General Services Administration Acquisition Regulation; Information Collection; GSA Form 527...

    Science.gov (United States)

    2012-02-01

    ... ADMINISTRATION General Services Administration Acquisition Regulation; Information Collection; GSA Form 527... and Financial Information'' on your attached document. Fax: (202) 501-4067. Mail: General Services... provided. SUPPLEMENTARY INFORMATION: A. Purpose The General Services Administration will be requesting...

  5. 78 FR 37698 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-67; Small Entity Compliance Guide

    Science.gov (United States)

    2013-06-21

    ... the National Defense Authorization Act (NDAA) for Fiscal Year (FY) 2008 (Pub. L. 110-181), as amended... amends the FAR to address concerns raised in an opinion from the U.S. Department of Justice Office of... Congress for Fiscal Year 2007 through Fiscal Year 2011 on acquisitions of end products manufactured...

  6. 78 FR 37667 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-67; Introduction

    Science.gov (United States)

    2013-06-21

    ... Authorization Act (NDAA) for Fiscal Year (FY) 2008 (Pub. L. 110-181), as amended by section 853 of the NDAA for... amends the FAR to address concerns raised in an opinion from the U.S. Department of Justice Office of... Congress for Fiscal Year 2007 through Fiscal Year 2011 on acquisitions of end products manufactured...

  7. 76 FR 76318 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2011-12-07

    ..., Contractor Code of Business Ethics and Conduct, is the DoD Office of Inspector General at the following... (Acquisition & Procurement)''; and 0 d. Removing the Defense Business Transformation Agency Contracting Office... procedures at PGI 205.207(a)(i). (d)(i) * * * (iii) For special notices for small business events, follow the...

  8. 77 FR 12937 - Federal Acquisition Regulation; Government Property

    Science.gov (United States)

    2012-03-02

    ... recommended changes are consistent with the Office of the Under Secretary of Defense, Acquisition, Technology... that reflect consistently applied generally accepted accounting principles. 0 8. Amend section 45.102... Technology: Ensuring Opportunity For All Children In The Next Century, April 17, 1996, and 15 U.S.C....

  9. 78 FR 80369 - Federal Acquisition Regulation; Service Contracts Reporting Requirements

    Science.gov (United States)

    2013-12-31

    ..., on a bilateral basis in accordance with FAR 1.108(d)(3), within six months of the effective date of... to 41 U.S.C. Sec. 1906 and states that the law applies to acquisitions of commercial items; or 3. Is... stipulation ``for services'' was added at FAR 4.1703(a)(1) and 4.1703(a)(3) to clarify that...

  10. 78 FR 2229 - Health and Human Services Acquisition Regulation

    Science.gov (United States)

    2013-01-10

    ... following methods: Regulations.gov : http://www.regulations.gov . Submit comments via the Federal e... comments received will be posted without change to http://www.regulations.gov . FOR FURTHER INFORMATION..., or an employee-inventor after consultation by the Agency with the Contractor, may request greater...

  11. 78 FR 30898 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Rights in...

    Science.gov (United States)

    2013-05-23

    ... Technical Data and Computer Software--Small Business Innovation Research (SBIR) Program. In accordance with... Regulation Supplement; Rights in Technical Data and Computer Software AGENCY: Defense Acquisition Regulations... in Technical Data, and Subpart 227.72, Rights in Computer Software and Computer Software...

  12. 76 FR 74722 - Office of Procurement and Property Management; Agriculture Acquisition Regulation, Labor Law...

    Science.gov (United States)

    2011-12-01

    ... Regulation, Labor Law Violations AGENCY: Office of Procurement and Property Management, Department of...'') to add a new clause at subpart 422.70 entitled ``Labor Law Violations.'' The rule is issued as a... subpart and clause entitled Labor Law Violations to the Agriculture Acquisition Regulation (AGAR)....

  13. 77 FR 30359 - Defense Federal Acquisition Regulation Supplement: New Free Trade Agreement With Colombia (DFARS...

    Science.gov (United States)

    2012-05-22

    ... Regulation Supplement: New Free Trade Agreement With Colombia (DFARS Case 2012-D032) AGENCY: Defense... United States--Colombia Trade Promotion ] Agreement. This Trade Promotion Agreement is a free trade... Federal Acquisition Regulation (FAR) as the Colombia Free Trade Agreement (FTA). The FTA provides for...

  14. 75 FR 34282 - Federal Acquisition Regulation; FAR Case 2009-013, Nonavailable Articles

    Science.gov (United States)

    2010-06-16

    ... Regulation; FAR Case 2009-013, Nonavailable Articles AGENCIES: Department of Defense (DoD), General Services... a final rule amending the Federal Acquisition Regulation (FAR) to revise the list of articles... The Buy American Act does not apply with respect to articles, materials, or supplies if...

  15. 77 FR 11367 - Defense Federal Acquisition Regulation Supplement; Extension of the Test Program for Negotiation...

    Science.gov (United States)

    2012-02-24

    ... Regulation Supplement; Extension of the Test Program for Negotiation of Comprehensive Small Business... Acquisition Regulation Supplement to extend the program period for the DoD Test Program for Negotiation of...). Section 866 amends the DoD Test Program for Negotiation of Comprehensive Small Business...

  16. 75 FR 25165 - Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting System

    Science.gov (United States)

    2010-05-07

    ... reporting requirements that are essential for the DoD to estimate the cost of current and future weapon... and not cost allocations. The description will also show how the data from the offeror's accounting... Regulation Supplement; Cost and Software Data Reporting System AGENCY: Defense Acquisition Regulations...

  17. 77 FR 2682 - Defense Federal Acquisition Regulation Supplement; DoD Voucher Processing

    Science.gov (United States)

    2012-01-19

    ... vouchers not selected for a pre-payment review will be considered to be provisionally approved and will be... after a pre-payment review. Interim vouchers not selected for a pre-payment review will be considered to... Regulation Supplement; DoD Voucher Processing AGENCY: Defense Acquisition Regulations System, Department...

  18. 75 FR 18034 - Defense Federal Acquisition Regulation Supplement; Research and Development Contract Type...

    Science.gov (United States)

    2010-04-08

    ... Regulation Supplement; Research and Development Contract Type Determination (DFARS Case 2006-D053) AGENCY... a major defense acquisition program (MDAP) to select the contract type for a development program... requires DoD to modify regulations regarding the determination of contract type for development programs...

  19. 76 FR 72327 - NASA Federal Acquisition Regulation Supplement; Responsibility, Suspension and Debarment

    Science.gov (United States)

    2011-11-23

    ... [Federal Register Volume 76, Number 226 (Wednesday, November 23, 2011)] [Rules and Regulations] [Pages 72327-72328] [FR Doc No: 2011-30148] NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 1809 RIN 2700-AD54 NASA Federal Acquisition Regulation Supplement; Responsibility, Suspension and...

  20. 75 FR 66686 - Defense Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption for...

    Science.gov (United States)

    2010-10-29

    ... Regulation Supplement; Balance of Payments Program Exemption for Commercial Information Technology... Acquisition Regulation Supplement (DFARS) to implement the exemption from the Balance of Payments Program for... is amending the DFARS to implement in the clauses at 252.225- 7044, Balance of Payments...

  1. 77 FR 44063 - Federal Acquisition Regulations; DARPA-New Mexico Tax Agreement

    Science.gov (United States)

    2012-07-26

    ... Federal Acquisition Regulations; DARPA-New Mexico Tax Agreement AGENCIES: Department of Defense (DoD... Regulation (FAR) to add the United States Defense Advanced Research Projects Agency (DARPA) to the list of agencies that have entered into separate tax agreements with the State of New Mexico (NM). The DARPA-NM...

  2. 75 FR 41097 - Homeland Security Acquisition Regulation; Lead System Integrators [HSAR Case 2009-003

    Science.gov (United States)

    2010-07-15

    ...The Department of Homeland Security (DHS) is issuing an interim rule amending the Homeland Security Acquisition Regulation (HSAR) to implement section 6405 of the U.S. Troop Readiness, Veterans' Care, Katrina Recovery, and Iraq Accountability Appropriations Act, 2007. This section of the Act and these implementing regulations restrict contractors from acting as lead system integrators in the......

  3. 78 FR 30304 - Federal Acquisition Regulation; Information Collection; Patents

    Science.gov (United States)

    2013-05-22

    ... Regulation; Information Collection; Patents AGENCY: Department of Defense (DOD), General Services... requirement concerning patents. DATES: Submit comments on or before July 22, 2013. ADDRESSES: Submit comments identified by Information Collection 9000- 0096, Patents, by any of the following methods:...

  4. 77 FR 67366 - Federal Acquisition Regulation; Information Collection; Travel Costs

    Science.gov (United States)

    2012-11-09

    ... Regulation; Information Collection; Travel Costs AGENCY: Department of Defense (DOD), General Services... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE... collection requirement concerning Travel Costs. Public comments are particularly invited on: Whether...

  5. 75 FR 51884 - Department of Education Acquisition Regulation

    Science.gov (United States)

    2010-08-23

    ... new contract with respect to the Service Contract Act. 3424 Protection of Privacy and Freedom of... from the FAR, and discusses career development, contracting authority, and responsibilities. Current... or on the nomination and appointment of contracting officer's representatives. Proposed Regulations...

  6. 75 FR 17410 - Federal Acquisition Regulation; Information Collection; Government Property

    Science.gov (United States)

    2010-04-06

    ... Regulation; Information Collection; Government Property AGENCY: Department of Defense (DOD), General Services... approved information collection requirement concerning Government Property. Public comments are.... Purpose Property, as used in Part 45, means all property, both real and personal. It includes...

  7. 76 FR 3637 - Annual Update of the HHS Poverty Guidelines

    Science.gov (United States)

    2011-01-20

    ... HUMAN SERVICES Office of the Secretary Annual Update of the HHS Poverty Guidelines AGENCY: Department of... Health and Human Services (HHS) poverty guidelines to account for last calendar year's increase in prices... Federal, State, or local office that is responsible for that program. For information about...

  8. 77 FR 4034 - Annual Update of the HHS Poverty Guidelines

    Science.gov (United States)

    2012-01-26

    ... HUMAN SERVICES Office of the Secretary Annual Update of the HHS Poverty Guidelines AGENCY: Department of... Health and Human Services (HHS) poverty guidelines to account for last calendar year's increase in prices... Federal, state, or local office that is responsible for that program. For information about...

  9. 78 FR 5182 - Annual Update of the HHS Poverty Guidelines

    Science.gov (United States)

    2013-01-24

    ... HUMAN SERVICES Office of the Secretary Annual Update of the HHS Poverty Guidelines AGENCY: Department of... Health and Human Services (HHS) poverty guidelines to account for last calendar year's increase in prices... Federal, state, or local office that is responsible for that program. For information about...

  10. Plant Nitrogen Acquisition Under Low Availability: Regulation of Uptake and Root Architecture.

    Science.gov (United States)

    Kiba, Takatoshi; Krapp, Anne

    2016-04-01

    Nitrogen availability is a major factor determining plant growth and productivity. Plants acquire nitrogen nutrients from the soil through their roots mostly in the form of ammonium and nitrate. Since these nutrients are scarce in natural soils, plants have evolved adaptive responses to cope with the environment. One of the most important responses is the regulation of nitrogen acquisition efficiency. This review provides an update on the molecular determinants of two major drivers of the nitrogen acquisition efficiency: (i) uptake activity (e.g. high-affinity nitrogen transporters) and (ii) root architecture (e.g. low-nitrogen-availability-specific regulators of primary and lateral root growth). Major emphasis is laid on the regulation of these determinants by nitrogen supply at the transcriptional and post-transcriptional levels, which enables plants to optimize nitrogen acquisition efficiency under low nitrogen availability.

  11. 77 FR 54864 - Federal Acquisition Regulation; Documenting Contractor Performance

    Science.gov (United States)

    2012-09-06

    ... solicitation provisions and clauses referenced in 9.104-7); (6) Integrity and business ethics; and (7) Business... posted without change to http://www.regulations.gov , including any personal and/or business confidential...--Evaluation Ratings Definitions (for the Small Business Subcontracting Evaluation factor when the clause at 52...

  12. 77 FR 51784 - Federal Acquisition Regulation; Information Collection; Qualification Requirements

    Science.gov (United States)

    2012-08-27

    .... Under the qualification requirements, an end item, or a component thereof, may be required to be... Regulation; Information Collection; Qualification Requirements AGENCY: Department of Defense (DOD), General...: Under the provisions of the Paperwork Reduction Act, the Regulatory Secretariat will be submitting...

  13. 77 FR 10529 - Federal Acquisition Regulation; Information Collection; Delivery Schedules

    Science.gov (United States)

    2012-02-22

    ..., Time of Delivery, or FAR 52.211-9, Desired and Required Time of Delivery. The information is needed to... Regulation; Information Collection; Delivery Schedules AGENCY: Department of Defense (DOD), General Services... requirement concerning delivery schedules. Public comments are particularly invited on: Whether this...

  14. 78 FR 26573 - Federal Acquisition Regulation; Irrevocable Letters of Credit

    Science.gov (United States)

    2013-05-07

    ... http://www.regulations.gov , including any personal and/or business confidential information provided... equity). E.O. 13563 emphasizes the importance of quantifying both costs and benefits, of reducing costs..., therefore, was not subject to review under section 6(b) of Executive Order 12866, Regulatory Planning...

  15. 77 FR 63805 - Federal Acquisition Regulation; Information Collection; Service Contracting

    Science.gov (United States)

    2012-10-17

    ... Regulation; Information Collection; Service Contracting AGENCY: Department of Defense (DOD), General Services.... Select the link ``Submit a Comment'' that corresponds with ``Information Collection 9000-0152, Service..., company name (if any), and ``Information Collection 9000-0152, Service Contracting'' on your...

  16. 78 FR 59317 - Federal Acquisition Regulation; Ending Trafficking in Persons

    Science.gov (United States)

    2013-09-26

    ...) Harmonize the requirements of 52.203-13, Contractor Code of Business Ethics and Conduct with the... posted without change to http://www.regulations.gov , including any personal and/or business confidential... performance, at the workplace and on the contractor's Web site (if one is maintained). Contractors would be...

  17. 78 FR 31551 - Federal Acquisition Regulation; Submission for OMB Review; Commerce Patent Regulations

    Science.gov (United States)

    2013-05-24

    ... Regulation; Submission for OMB Review; Commerce Patent Regulations AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Department of Commerce patent regulations. A notice... Collection 9000- 0095, Commerce Patent Regulations, by any of the following methods: Regulations.gov :...

  18. 75 FR 82029 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1217...

    Science.gov (United States)

    2010-12-29

    ... Doc No: 2010-32775] GENERAL SERVICES ADMINISTRATION [OMB Control No. 3090-00XX; Docket 2010-0002; Sequence 15] General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1217, Lessor's Annual Cost Statement AGENCY: Department of Defense (DOD), General...

  19. 75 FR 38675 - Federal Acquisition Regulation; FAR Case 2008-011, Government Property

    Science.gov (United States)

    2010-07-02

    ... Property AGENCIES: Department of Defense (DoD), General Services Administration (GSA), and National... the Federal Acquisition Regulation (FAR) to revise FAR part 45, Government Property, and its... corrects the previous FAR rule for part 45, Government Property, published under FAC 2005-17, FAR Case 2004...

  20. 77 FR 13069 - Department of the Treasury Acquisition Regulation; Internet Payment Platform; Correction

    Science.gov (United States)

    2012-03-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY 48 CFR Chapter 10 RIN 1505-AC41 Department of the Treasury Acquisition Regulation; Internet Payment Platform; Correction AGENCY: Office of the Procurement Executive, Treasury. ACTION: Proposed...

  1. 77 FR 50454 - Department of the Treasury Acquisition Regulations; Contract Clause on Minority and Women...

    Science.gov (United States)

    2012-08-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY 48 CFR Chapter 10 RIN 1505-AC40 Department of the Treasury Acquisition Regulations; Contract Clause on Minority and Women Inclusion in Contractor Workforce AGENCY: Departmental Offices,...

  2. 77 FR 10714 - Department of the Treasury Acquisition Regulation; Internet Payment Platform

    Science.gov (United States)

    2012-02-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY 48 CFR Chapter 10 RIN 1505-AC41 Department of the Treasury Acquisition Regulation; Internet Payment Platform AGENCY: Office of the Procurement Executive, Treasury. ACTION: Notice of proposed...

  3. 77 FR 40302 - Department of the Treasury Acquisition Regulation; Internet Payment Platform

    Science.gov (United States)

    2012-07-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY 48 CFR Parts 1002, 1032, and 1052 RIN 1505-AC41 Department of the Treasury Acquisition Regulation; Internet Payment Platform AGENCY: Office of the Procurement Executive, Treasury. ACTION: Final...

  4. 77 FR 17352 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Science.gov (United States)

    2012-03-26

    ... Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program Correction In rule document 2012...-Aside for Women-Owned Small Business (WOSB) Concerns Eligible Under the WOSB Program (APR 2012) (15 U.S... Disadvantaged Women- Owned Small Business Concerns. * * * * * Notice of Set-Aside for Economically...

  5. 77 FR 68699 - Defense Federal Acquisition Regulation Supplement: New Free Trade Agreement-Panama (DFARS Case...

    Science.gov (United States)

    2012-11-16

    ... Federal Acquisition Regulation Supplement: New Free Trade Agreement--Panama (DFARS Case 2012-D044) AGENCY... implement the United States-Panama Trade Promotion Agreement. This Trade Promotion Agreement is a free trade... Panama Free Trade Agreement (FTA). The FTA provides for-- Waiver of the applicability of the Buy American...

  6. 78 FR 37695 - Federal Acquisition Regulation; Free Trade Agreement (FTA)-Panama

    Science.gov (United States)

    2013-06-21

    ... 9000-AM43 Federal Acquisition Regulation; Free Trade Agreement (FTA)-Panama AGENCY: Department of... Promotion Agreement. This Trade Promotion Agreement is a free trade agreement that provides for mutually non... Panama to the definition of ``Free Trade Agreement country'' in multiple locations in the FAR. The Panama...

  7. 76 FR 81554 - 60-Day Notice of Proposed Information Collection: Department of State Acquisition Regulation (DOSAR)

    Science.gov (United States)

    2011-12-28

    ... Collection: Department of State Acquisition Regulation (DOSAR). OMB Control Number: 1405-0050. Type of... of the Procurement Executive (A/OPE). Form Number: N/A. Respondents: Any business, other for-profit, individual, not-for-profit, or household organizations wishing to receive Department of State...

  8. 77 FR 76939 - Defense Federal Acquisition Regulation Supplement: Definition of Cost or Pricing Data (DFARS Case...

    Science.gov (United States)

    2012-12-31

    ... 0750-AH49 Defense Federal Acquisition Regulation Supplement: Definition of Cost or Pricing Data (DFARS... consistency with FAR changes addressing the definition of cost or pricing data which clarified the distinction... the DFARS to update the text addressing the definition of cost or pricing data by inserting the...

  9. 76 FR 61296 - Defense Federal Acquisition Regulation Supplement: Contracting With the Canadian Commercial...

    Science.gov (United States)

    2011-10-04

    ... October 1, 2010, the definitions in the Federal Acquisition Regulation (FAR) relating to cost or pricing... other than certified cost or pricing data.'' The new definition of these terms in the FAR is significant..., Definition of Cost or Pricing Data, are not yet implemented. Therefore, this rule includes conforming...

  10. 77 FR 2680 - Defense Federal Acquisition Regulation Supplement; Definition of Cost or Pricing Data

    Science.gov (United States)

    2012-01-19

    ... RIN 0750-AH49 Defense Federal Acquisition Regulation Supplement; Definition of Cost or Pricing Data... text addressing the definition of cost or pricing data. The DFARS changes are necessary to ensure... definition of cost or pricing data, published at 75 FR 53135 on August 30, 2010. II. Executive Orders...

  11. 77 FR 11355 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2012-02-24

    ... Defense Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration (DFARS... proposed rule for Business Systems-- Definition and Administration (DFARS Case 2009-D038) in the Federal... contractor business systems, DoD has clarified the definition and administration of contractor...

  12. 75 FR 75549 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-03

    ... Acquisition Regulation Supplement; Business Systems-- Definition and Administration (DFARS Case 2009-D038...D published a proposed rule for Business Systems--Definition and Administration (DFARS Case 2009... contractor business systems, DoD is considering a rule to clarify the definition and administration...

  13. 77 FR 4631 - Defense Federal Acquisition Regulation Supplement: New Designated Country-Armenia (DFARS Case...

    Science.gov (United States)

    2012-01-30

    ... ``designated country'' at DFARS 252.225-7021, Trade Agreements, and 252.225-7045, Balance of Payments Program... ``Designated country'', revise paragraph (1) to read as follows: 252.225-7045 Balance of Payments Program... amending the Defense Federal Acquisition Regulation Supplement (DFARS) to add Armenia as a World Trade...

  14. 75 FR 73997 - Defense Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010...

    Science.gov (United States)

    2010-11-30

    ..., entitled ``Efforts to Prevent Sexual Assault/Harassment Involving DoD Contractors During Contingency...; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY: Defense Acquisition Regulations System... are aware of the DoD definition of ``sexual assault'' as defined in DoD Directive 6495.01,...

  15. 76 FR 38051 - Defense Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010...

    Science.gov (United States)

    2011-06-29

    .... Background DoD Inspector General audit D-2010-052, entitled ``Efforts to Prevent Sexual Assault/Harassment... Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY: Defense Acquisition... accompanying U.S. Armed Forces are made aware of the DoD definition of sexual assault as defined in...

  16. 76 FR 31416 - Federal Acquisition Regulation; Oversight of Contractor Ethics Programs

    Science.gov (United States)

    2011-05-31

    ... Federal Acquisition Regulation; Oversight of Contractor Ethics Programs AGENCY: Department of Defense (DoD... contractors have implemented the mandatory contractor business ethics program requirements. DATES: Effective... to Improve DoD's Oversight of Contractor Ethics Programs. The ethics program requirement flows from...

  17. 76 FR 78858 - Defense Federal Acquisition Regulation Supplement; Utilization of Domestic Photovoltaic Devices...

    Science.gov (United States)

    2011-12-20

    ... adverse effects on the U.S. photovoltaic industry, which this statute was designed to protect. However... Acquisition Regulation Supplement; Utilization of Domestic Photovoltaic Devices (DFARS Case 2011-D046) AGENCY... 2011. The section provides that photovoltaic devices to be utilized in performance of any covered...

  18. 78 FR 38539 - Federal Acquisition Regulation; Applicability of the Senior Executive Compensation Benchmark

    Science.gov (United States)

    2013-06-26

    ... Federal Acquisition Regulation; Applicability of the Senior Executive Compensation Benchmark AGENCY..., 2011) of the application of the senior executive compensation benchmark amount. Section 803 expands to...'' screen. Please include your name, company name (if any), and ``FAR Case 2012-025'' on your...

  19. 75 FR 65437 - Defense Federal Acquisition Regulation Supplement; Defense Cargo Riding Gang Members (DFARS Case...

    Science.gov (United States)

    2010-10-25

    ... Acquisition Regulation Supplement; Defense Cargo Riding Gang Members (DFARS Case 2007-D002) AGENCY: Defense... 3504 addresses requirements that apply to riding gang members and DoD- exempted individuals who perform.... 109-364). Section 3504 addresses requirements that apply to riding gang members and...

  20. 77 FR 52252 - Defense Federal Acquisition Regulation Supplement: Inflation Adjustment of Threshold for...

    Science.gov (United States)

    2012-08-29

    ...-related dollar thresholds subject to inflation adjustment in accordance with the requirements of 41 U.S.C... Regulation Supplement: Inflation Adjustment of Threshold for Acquisition of Right-Hand Drive Passenger Sedans... Authorization Act for Fiscal Year 2012 that requires adjustment of the statutory dollar limitation on...

  1. 78 FR 28756 - Defense Federal Acquisition Regulation Supplement: System for Award Management Name Changes...

    Science.gov (United States)

    2013-05-16

    ... 0750-AH87 Defense Federal Acquisition Regulation Supplement: System for Award Management Name Changes... System (EPLS) databases into the System for Award Management (SAM) database. DATES: Effective Date: May... effort to improve the management and promotion of electronic Government services and processes. The Act...

  2. 78 FR 46792 - Federal Acquisition Regulation; Least Developed Countries That Are Designated Countries

    Science.gov (United States)

    2013-08-01

    ... 9000-AM62 Federal Acquisition Regulation; Least Developed Countries That Are Designated Countries... Representative (USTR) to the list of least developed countries that are designated countries under the Trade... President to designate least developed countries as eligible countries under the Trade Agreements Act...

  3. 75 FR 33237 - Defense Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS...

    Science.gov (United States)

    2010-06-11

    ...; Contractor Insurance/Pension Review (DFARS Case 2009-D025) AGENCY: Defense Acquisition Regulations System... and relocate the requirements for conducting a Contractor Insurance/Pension Review from Procedures... requirements for Contractor Insurance/Pension Review (CIPR) from DFARS 242.7302 to Procedures, Guidance, and...

  4. 75 FR 82575 - Federal Acquisition Regulation; Personal Identity Verification of Contractor Personnel

    Science.gov (United States)

    2010-12-30

    ... respondents stated that they have concerns over what happens when a contractor claims to have lost an identity... Federal Acquisition Regulation; Personal Identity Verification of Contractor Personnel AGENCY: Department...) were in place and worked as intended. A ``CAC'' is the DoD term for a Personal Identity...

  5. 78 FR 19467 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Science.gov (United States)

    2013-04-01

    ... Number: Defense Federal Acquisition Regulation Supplement (DFARS), Appendix I, DoD Pilot Mentor-Protege... purposes of the DoD Pilot Mentor-Protege Program have been met. The purposes of the Program are to (1) provide incentives to major DoD contractors to assist protege firms in enhancing their capabilities...

  6. 78 FR 48397 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Transportation (DFARS...

    Science.gov (United States)

    2013-08-08

    .... Manuel Quinones, Editor, Defense Acquisition Regulations System. Therefore, 48 CRF parts 212, 216, 247..., subassemblies, accessories, and equipment; machine tools; material; equipment; stores of all kinds; end items...; equipment; stores of all kinds; end items; construction materials; and components of the foregoing. (7)...

  7. 75 FR 28771 - Federal Acquisition Regulation; FAR Case 2009-027, Personal Identity Verification of Contractor...

    Science.gov (United States)

    2010-05-24

    ...: 9000-AL60 Federal Acquisition Regulation; FAR Case 2009-027, Personal Identity Verification of..., company name (if any), and ``FAR Case 2009-027'' on your attached document. Fax: 202-501-4067. Mail... over contractor CACs. A CAC is the DoD term for a Personal Identity Verification (PIV) card. A PIV...

  8. 75 FR 10191 - Defense Federal Acquisition Regulation Supplement (DFARS); DFARS Case 2009-D017, Continuation of...

    Science.gov (United States)

    2010-03-05

    ... address shown below on or before May 4, 2010, to be considered in the formation of the final rule... Acquisition Regulations System, Crystal Square 4, Suite 200A, 241 18th Street, Arlington, VA 22202- 3402... components to rely on the most effective mix of the total force, cost and other factors considered,...

  9. 78 FR 6189 - Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor Excise...

    Science.gov (United States)

    2013-01-29

    ... 9000-AM13 Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor... excise tax on certain Federal procurement payments to foreign persons. The rule disallows the cost associated with the 2 percent excise tax on certain foreign procurements. DATES: Effective Date: February 28...

  10. 77 FR 43082 - Federal Acquisition Regulation; Information Collection; Commerce Patent Regulations

    Science.gov (United States)

    2012-07-23

    ... Regulation; Information Collection; Commerce Patent Regulations AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Department of Commerce patent regulations. Public...: Submit comments identified by Information Collection 9000- 0095, Commerce Patent Regulations, by any...

  11. The world merger and acquisition market: economic dimensions and specifics of regulation

    Directory of Open Access Journals (Sweden)

    Oxana Davydovych

    2007-01-01

    Full Text Available The article presents a comprehensive analysis of the world mergers and acquisitions (M&A market, describing its stages of evolution and examining the trends and specific features of development at different stages. The author identifies the motives of mergers and acquisitions, determines their impact on the economy, makes an attempt at revealing the main reasons for failed M&A deals, analyzes the specifics of regulating mergers in the European Union countries, and describes their main requirements. The article also evaluates the development of the M&A processes in Central and Eastern Europe, in particular Ukraine. In conclusion, the author offers recommendations for the successful operation of companies after their merger or acquisition and considers the factors of the M&A market’s positive dynamics at the current stage.

  12. A two-component system regulates hemin acquisition in Porphyromonas gingivalis.

    Directory of Open Access Journals (Sweden)

    Jodie C Scott

    Full Text Available Porphyromonas gingivalis is a Gram-negative oral anaerobe associated with infection of the periodontia. The organism has a small number of two-component signal transduction systems, and after comparing genome sequences of strains W83 and ATCC 33277 we discovered that the latter was mutant in histidine kinase (PGN_0752, while the cognate response regulator (PGN_0753 remained intact. Microarray-based transcriptional profiling and ChIP-seq assays were carried out with an ATCC 33277 transconjugant containing the functional histidine kinase from strain W83 (PG0719. The data showed that the regulon of this signal transduction system contained genes that were involved in hemin acquisition, including gingipains, at least three transport systems, as well as being self-regulated. Direct regulation by the response regulator was confirmed by electrophoretic mobility shift assays. In addition, the system appears to be activated by hemin and the regulator acts as both an activator and repressor.

  13. 75 FR 5716 - Federal Acquisition Regulation; FAR Case 2008-024, Inflation Adjustment of Acquisition-Related...

    Science.gov (United States)

    2010-02-04

    ... divisible by 5) of acquisition-related thresholds for inflation using the Consumer Price Index for all urban... thresholds for inflation using the Consumer Price Index (CPI) for all- urban consumers. Acquisition-related... Consumer Price Index for all urban consumers, except for Davis-Bacon Act, Service Contract Act, and trade...

  14. 42 CFR 93.227 - Secretary or HHS.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Secretary or HHS. 93.227 Section 93.227 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  15. Organ acquisition cost centers Part I: medicare regulations--truth or consequence.

    Science.gov (United States)

    Abecassis, M

    2006-12-01

    Organ Acquisition Cost Centers (OACC) were designed to encourage and incentivize hospitals to provide transplantation services. The purpose of this article (Part I) is to familiarize transplant professionals and transplant center administrators with the regulations that govern OACC. An historical perspective of the evolution of these regulations is necessary to better understand the basic principles underlying this complex area of transplant finance. There is a wide variation in transplant center OACC reporting, suggesting under-reporting by some and overreporting by others. Correct reporting is essential since OACC are auditable. We have surveyed 13 audits by the Office of the Inspector General (OIG) of transplant center OACC in an attempt to identify trends in reporting practices by transplant centers that are not deemed acceptable by the OIG. We discuss these findings in the context of some basic definitions that refer specifically to cost accounting principles necessary for accurate reporting of OACC.

  16. 76 FR 21849 - Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card® and...

    Science.gov (United States)

    2011-04-19

    ... (DFARS) to allow the use of U.S. Government fuel cards in lieu of a Purchase Order-Invoice-Voucher for... Acquisition (SEA) ] Card in lieu of the SF 44, Purchase Order-Invoice-Voucher, up to the simplified... U.S. Government fuel cards in lieu of a Purchase Order-Invoice-Voucher for fuel, oil, and...

  17. Regulation of iron acquisition responses in plant roots by a transcription factor.

    Science.gov (United States)

    Bauer, Petra

    2016-09-10

    The presented research hypothesis-driven laboratory exercise teaches advanced undergraduate students state of the art methods and thinking in an integrated molecular physiology context. Students understand the theoretical background of iron acquisition in the model plant Arabidopsis thaliana. They design a flowchart summarizing the key steps of the experimental approach. Students are made familiar with current techniques such as qPCR. Following their experimental outline, students grow Arabidopsis seedlings up to the age of six days under sufficient and deficient iron supply. The Arabidopsis plants are of two different genotypes, namely wild type and fit loss of function mutants. fit mutants lack the essential transcription factor FIT, required for iron acquisition and plant growth. Students monitor growth phenotypes and root iron reductase activity in a quantitative and qualitative manner. Then, students determine gene expression regulation of FIT, FRO2, and a reference gene by reverse transcription-quantitative PCR (RT-qPCR). Finally, students interpet their results and build a model summarizing the connections between morphological, physiological and molecular iron deficiency responses. Learning outcomes and suggestions for integrating the course concept are explained. © 2016 by The International Union of Biochemistry and Molecular Biology, 44(5):438-449, 2016.

  18. Possession, Use, and Transfer of Select Agents and Toxins-- Addition of Bacillus Cereus Biovar Anthracis to the HHS List of Select Agents and Toxins. Interim final rule and request for comments.

    Science.gov (United States)

    2016-09-14

    The Centers for Disease Control and Prevention (CDC) in the Department of Health and Human Services (HHS) is adding Bacillus cereus Biovar anthracis to the list of HHS select agents and toxins as a Tier 1 select agent. We are taking this action to regulate this agent that is similar to B. anthracis to prevent its misuse, which could cause a biological threat to public health and/or national security.

  19. The Effects of Self-Regulation on Science Vocabulary Acquisition of English Language Learners with Learning Difficulties

    Science.gov (United States)

    Kim, Woori; Linan-Thompson, Sylvia

    2013-01-01

    This multiple-probe study examined the effects of self-regulation on the acquisition of science vocabulary by four third-grade English language learners (ELLs) with learning difficulties. The students were provided only direct vocabulary instruction in a baseline phase, followed by intervention and maintenance phases into which self-regulation…

  20. 78 FR 59861 - VA Acquisition Regulation: Service-Disabled Veteran-Owned and Veteran-Owned Small Business Status...

    Science.gov (United States)

    2013-09-30

    ... (definition service-disabled Veteran)''. Upon rendering a decision, new VAAR 819.307(g) provides that the... AFFAIRS 48 CFR Part 819 RIN 2900-AM92 VA Acquisition Regulation: Service-Disabled Veteran-Owned and... Service-Disabled Veteran-Owned Small Businesses (SDVOSB) and Veteran-Owned Small Businesses (VOSB)...

  1. 75 FR 13422 - Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer...

    Science.gov (United States)

    2010-03-19

    ... Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer Contracts... Architect-Engineer Contracts, currently requires contracting officers to withhold 10 percent of the amounts... payment withheld to apply under fixed-price architect-engineer (A-E) contracts (based on an assessment...

  2. The Effects of Self-Regulation on Science Vocabulary Acquisition of English Language Learners with Learning Difficulties

    Science.gov (United States)

    Kim, Woori; Linan-Thompson, Sylvia

    2013-01-01

    This multiple-probe study examined the effects of self-regulation on the acquisition of science vocabulary by four third-grade English language learners (ELLs) with learning difficulties. The students were provided only direct vocabulary instruction in a baseline phase, followed by intervention and maintenance phases into which self-regulation…

  3. 76 FR 71928 - Defense Federal Acquisition Regulation Supplement; Updates to Wide Area WorkFlow (DFARS Case 2011...

    Science.gov (United States)

    2011-11-21

    ... Contractor shall-- (1) Have a designated electronic business point of contact in the Central Contractor... and receiving reports in electronic format. DATES: Comments on the proposed rule should be submitted... procedures in the Defense Federal Acquisition Regulation Supplement (DFARS) for electronic submission...

  4. 77 FR 194 - Federal Acquisition Regulation; Time-and-Materials and Labor-Hour Contracts for Commercial Items

    Science.gov (United States)

    2012-01-03

    ... material; (4) Clarify contract types; (5) Potential for rule to limit the use of T&M contracts; (6...) The ordering activity shall specify the order type (i.e., firm-fixed price, time- and-materials, or... RIN 9000-AL74 Federal Acquisition Regulation; Time-and-Materials and Labor-Hour Contracts...

  5. 75 FR 38683 - Federal Acquisition Regulation; FAR Case 2008-035, Registry of Disaster Response Contractors

    Science.gov (United States)

    2010-07-02

    ... officers to take advantage of commercially available market research methods to identify capabilities to..., contracting officers are required to consult the registry during market research and acquisition planning....

  6. 75 FR 18041 - Defense Federal Acquisition Regulation Supplement; Minimizing Use of Hexavalent Chromium (DFARS...

    Science.gov (United States)

    2010-04-08

    ... platforms due to its corrosion protection properties. On April 8, 2009, the Under Secretary of Defense (Acquisition, Technology and Logistics) issued a memorandum establishing policy for the minimization...

  7. 77 FR 52739 - Federal Acquisition Regulation; Information Collection; Integrity of Unit Prices

    Science.gov (United States)

    2012-08-30

    ... contracts below the simplified acquisition threshold, construction and architect-engineering services... and methodology; ways to enhance the quality, utility, and clarity of the information to be...

  8. Microevolution analysis of Bacillus coahuilensis unveils differences in phosphorus acquisition strategies and their regulation

    Directory of Open Access Journals (Sweden)

    Zulema eGómez-Lunar

    2016-02-01

    Full Text Available Bacterial genomes undergo numerous events of gene losses and gains that generate genome variability among strains of the same species (microevolution. Our aim was to compare the genomes and relevant phenotypes of three Bacillus coahuilensis strains from two oligotrophic hydrological systems in the Cuatro Ciénegas Basin (México, to unveil the environmental challenges that this species cope with, and the microevolutionary differences in these genotypes. Since the strains were isolated from a low P environment, we placed emphasis on the search of different phosphorus acquisition strategies. The three B. coahuilensis strains exhibited similar numbers of coding DNA sequences, of which 82% (2, 893 constituted the core genome, and 18% corresponded to accessory genes. Most of the genes in this last group were associated with mobile genetic elements or were annotated as hypothetical proteins. Ten percent of the pangenome consisted of strain-specific genes. Alignment of the three B. coahuilensis genomes indicated a high level of synteny and revealed the presence of several genomic islands. Unexpectedly, one of these islands contained genes that encode the 2-keto-3-deoxymannooctulosonic acid (Kdo biosynthesis enzymes, a feature associated to cell walls of Gram-negative bacteria. Some microevolutionary changes were clearly associated with mobile genetic elements. Our analysis revealed inconsistencies between phenotype and genotype, which we suggest result from the impossibility to map regulatory features to genome analysis. Experimental results revealed variability in the types and numbers of auxotrophies between the strains that could not consistently be explained by in silico metabolic models. Several intraspecific differences in preferences for carbohydrate and phosphorus utilization were observed. Regarding phosphorus recycling, scavenging, and storage, variations were found between the three genomes. The three strains exhibited differences regarding

  9. Microevolution Analysis of Bacillus coahuilensis Unveils Differences in Phosphorus Acquisition Strategies and Their Regulation.

    Science.gov (United States)

    Gómez-Lunar, Zulema; Hernández-González, Ismael; Rodríguez-Torres, María-Dolores; Souza, Valeria; Olmedo-Álvarez, Gabriela

    2016-01-01

    Bacterial genomes undergo numerous events of gene losses and gains that generate genome variability among strains of the same species (microevolution). Our aim was to compare the genomes and relevant phenotypes of three Bacillus coahuilensis strains from two oligotrophic hydrological systems in the Cuatro Ciénegas Basin (México), to unveil the environmental challenges that this species cope with, and the microevolutionary differences in these genotypes. Since the strains were isolated from a low P environment, we placed emphasis on the search of different phosphorus acquisition strategies. The three B. coahuilensis strains exhibited similar numbers of coding DNA sequences, of which 82% (2,893) constituted the core genome, and 18% corresponded to accessory genes. Most of the genes in this last group were associated with mobile genetic elements (MGEs) or were annotated as hypothetical proteins. Ten percent of the pangenome consisted of strain-specific genes. Alignment of the three B. coahuilensis genomes indicated a high level of synteny and revealed the presence of several genomic islands. Unexpectedly, one of these islands contained genes that encode the 2-keto-3-deoxymannooctulosonic acid (Kdo) biosynthesis enzymes, a feature associated to cell walls of Gram-negative bacteria. Some microevolutionary changes were clearly associated with MGEs. Our analysis revealed inconsistencies between phenotype and genotype, which we suggest result from the impossibility to map regulatory features to genome analysis. Experimental results revealed variability in the types and numbers of auxotrophies between the strains that could not consistently be explained by in silico metabolic models. Several intraspecific differences in preferences for carbohydrate and phosphorus utilization were observed. Regarding phosphorus recycling, scavenging, and storage, variations were found between the three genomes. The three strains exhibited differences regarding alkaline phosphatase that

  10. Microevolution Analysis of Bacillus coahuilensis Unveils Differences in Phosphorus Acquisition Strategies and Their Regulation

    Science.gov (United States)

    Gómez-Lunar, Zulema; Hernández-González, Ismael; Rodríguez-Torres, María-Dolores; Souza, Valeria; Olmedo-Álvarez, Gabriela

    2016-01-01

    Bacterial genomes undergo numerous events of gene losses and gains that generate genome variability among strains of the same species (microevolution). Our aim was to compare the genomes and relevant phenotypes of three Bacillus coahuilensis strains from two oligotrophic hydrological systems in the Cuatro Ciénegas Basin (México), to unveil the environmental challenges that this species cope with, and the microevolutionary differences in these genotypes. Since the strains were isolated from a low P environment, we placed emphasis on the search of different phosphorus acquisition strategies. The three B. coahuilensis strains exhibited similar numbers of coding DNA sequences, of which 82% (2,893) constituted the core genome, and 18% corresponded to accessory genes. Most of the genes in this last group were associated with mobile genetic elements (MGEs) or were annotated as hypothetical proteins. Ten percent of the pangenome consisted of strain-specific genes. Alignment of the three B. coahuilensis genomes indicated a high level of synteny and revealed the presence of several genomic islands. Unexpectedly, one of these islands contained genes that encode the 2-keto-3-deoxymannooctulosonic acid (Kdo) biosynthesis enzymes, a feature associated to cell walls of Gram-negative bacteria. Some microevolutionary changes were clearly associated with MGEs. Our analysis revealed inconsistencies between phenotype and genotype, which we suggest result from the impossibility to map regulatory features to genome analysis. Experimental results revealed variability in the types and numbers of auxotrophies between the strains that could not consistently be explained by in silico metabolic models. Several intraspecific differences in preferences for carbohydrate and phosphorus utilization were observed. Regarding phosphorus recycling, scavenging, and storage, variations were found between the three genomes. The three strains exhibited differences regarding alkaline phosphatase that

  11. 76 FR 40368 - Federal Acquisition Regulation; Submission for OMB Review; Environmentally Sound Products

    Science.gov (United States)

    2011-07-08

    ... RCRA must contain, as a minimum (1) a recovered materials preference program and an agency promotion... acquisitions requiring minimum percentages of recovered materials, ] when the price of the item exceeds...

  12. 76 FR 34886 - General Services Administration Acquisition Regulation; Implementation of Information Technology...

    Science.gov (United States)

    2011-06-15

    ... of Information Technology Security Provision AGENCY: Office of Acquisition Policy, General Services... to implement policy and guidelines for contracts and orders that include information technology (IT... information technology (IT) supplies, services and systems with security requirements. Comment...

  13. 76 FR 11361 - Defense Federal Acquisition Regulation Supplement; Preservation of Tooling for Major Defense...

    Science.gov (United States)

    2011-03-02

    ... comment period closed July 6, 2010. Four respondents submitted comments on six issues. A discussion of the... Acquisition, Technology, and Logistics (USD (AT&L)) may waive this requirement if USD (AT&L) determines that...

  14. 75 FR 3734 - 2009 HHS Poverty Guidelines Extended Until March 1, 2010

    Science.gov (United States)

    2010-01-22

    ... HUMAN SERVICES Office of the Secretary 2009 HHS Poverty Guidelines Extended Until March 1, 2010 AGENCY... Human Services (HHS) poverty guidelines will remain in effect until updated 2010 poverty guidelines are... Federal, State, or local office that is responsible for that program. For information about...

  15. 75 FR 45628 - Delayed Update of the HHS Poverty Guidelines for the Remainder of 2010

    Science.gov (United States)

    2010-08-03

    ... HUMAN SERVICES Office of the Secretary Delayed Update of the HHS Poverty Guidelines for the Remainder of... delayed update of the Department of Health and Human Services (HHS) poverty guidelines for the remainder of 2010, and until the 2011 poverty guidelines are published, which is expected to occur in...

  16. Notification: Hotline Complaint – Region 7 Compliance with Bid, Payment, and Performance Bond Requirements Outlined in Federal Acquisition Regulation (FAR) Part 28

    Science.gov (United States)

    June 1, 2012. In response to an anonymous hotline complaint, the OIG plans to conduct a review of Region 7’s compliance with bid, payment, and performance bond requirements outlined in Federal Acquisition Regulation (FAR) Part 28.

  17. 77 FR 9658 - General Services Administration Acquisition Regulation; Information Collection; Preparation...

    Science.gov (United States)

    2012-02-17

    ... information collection will ensure that small and small disadvantaged business concerns are afforded the...), submission of a subcontracting plan with other than small business concerns when a negotiated acquisition... information is accurate, and based on valid assumptions and methodology; ways to enhance the quality, utility...

  18. Regulation of Iron Acquisition Responses in Plant Roots by a Transcription Factor

    Science.gov (United States)

    Bauer, Petra

    2016-01-01

    The presented research hypothesis-driven laboratory exercise teaches advanced undergraduate students state of the art methods and thinking in an integrated molecular physiology context. Students understand the theoretical background of iron acquisition in the model plant "Arabidopsis thaliana." They design a flowchart summarizing the key…

  19. 78 FR 48331 - Defense Federal Acquisition Regulation Supplement: Release of Fundamental Research Information...

    Science.gov (United States)

    2013-08-08

    ... the Under Secretary of Defense for Acquisition, Technology and Logistics (AT&L) in a memorandum on... Executive Orders (E.O.s) 12866 and 13563 direct agencies to assess all costs and benefits of available... impacts, and equity). E.O. 13563 emphasizes the importance of quantifying both costs and benefits, of...

  20. 75 FR 26916 - Federal Acquisition Regulation: FAR Case 2009-004, Enhancing Contract Transparency

    Science.gov (United States)

    2010-05-13

    ... GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 24 RIN 9000-AL59... Defense (DoD), General Services Administration (GSA), and National Aeronautics and Space Administration... promote efficiency in Government contracting through an open acquisition process and improve...

  1. 78 FR 30233 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Science.gov (United States)

    2013-05-22

    ... Register at 76 FR 11363 on March 2, 2011, to implement section 821 of the National Defense Authorization... covered, including recognizing the inherent elements of a generic ``use'' that are expressly distinguished... information in the course of advising the Government on overall acquisition strategies. The...

  2. 77 FR 52254 - Defense Federal Acquisition Regulation Supplement: Reporting of Government-Furnished Property...

    Science.gov (United States)

    2012-08-29

    ... spirit of the `Duncan Hunter National Defense Acquisition Act of FY 2009 * * * Section 815.' '' The... Management Agency managed electronic tools: Plant Clearance Automated Reutilization and Screening System, and... items that are-- (i) Received by the Contractor; (ii) Delivered or shipped from the Contractor's plant...

  3. 77 FR 19127 - Defense Federal Acquisition Regulation Supplement; Inflation Adjustment of Threshold for...

    Science.gov (United States)

    2012-03-30

    ... sedans be included on the list of dollar thresholds subject to inflation adjustment. DATES: Effective... included on the list of dollar thresholds subject to inflation adjustment in accordance with the... sedans in the list of statutory acquisition-related dollar thresholds to be adjusted for inflation....

  4. 75 FR 20954 - Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest in Major...

    Science.gov (United States)

    2010-04-22

    ... journals; and (D) Business directories and registers. (3) In competitive acquisitions, whether by sealed... Office of Government Ethics (OGE) pursuant to section 841(b) of the Duncan Hunter National Defense... addressed along with improper business practices and personal conflicts of interest; Standard provisions...

  5. 75 FR 32640 - Defense Federal Acquisition Regulation Supplement; Finland- Public Interest Exception to the Buy...

    Science.gov (United States)

    2010-06-08

    ... or the Balance of Payments Program to the acquisition of qualifying country end products from the... exempted from application of the Buy American Act and the Balance of Payments Program as inconsistent with... France Greece Israel Italy Luxembourg Netherlands Norway Portugal Spain Sweden Switzerland Turkey...

  6. 75 FR 13131 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Advantage...

    Science.gov (United States)

    2010-03-18

    ...! and Electronic Commerce- FACNET AGENCY: Office of the Chief Acquisition Officer, GSA. ACTION: Notice... collection requirement regarding GSA Advantage! and Electronic Commerce-FACNET. A request for public comments..., Washington, DC 20405. Please cite OMB Control No. 3090-00XX, GSA Advantage! and Electronic...

  7. 76 FR 57677 - Defense Federal Acquisition Regulation Supplement; Increase the Use of Fixed-Price Incentive...

    Science.gov (United States)

    2011-09-16

    ..., Technology, & Logistics (USD(AT&L)), dated November 3, 2010. The memorandum provided guidance to the... Secretary of Defense for Acquisition, Technology, & Logistics in a memorandum dated November 3, 2010. The... for commercial products, including commercially available off-the-shelf products, for which...

  8. 75 FR 14095 - Defense Federal Acquisition Regulation Supplement; Appendix A, Armed Services Board of Contract...

    Science.gov (United States)

    2010-03-24

    ...; Appendix A, Armed Services Board of Contract Appeals, Part 1--Charter AGENCY: Defense Acquisition... Charter of the Armed Services Board of Contract Appeals (ASBCA), dated May 14, 2007. The ASBCA is... of records and to such other instruments as the Board may determine. 11. This revised charter...

  9. 78 FR 37980 - Defense Federal Acquisition Regulation Supplement: Solicitation Provisions and Contract Clauses...

    Science.gov (United States)

    2013-06-25

    ... has retained in the final rule the language at 252.244-7000(b), which is the same as FAR 52.244-6(c)(2... Comments Several respondents had editorial comments as to the language within the rule. Comment: One... the clause at 252.225-7008, Restriction on Acquisition of Specialty Metals, as prescribed in...

  10. 77 FR 39140 - Defense Federal Acquisition Regulation Supplement: Shipping Instructions (DFARS Case 2011-D052)

    Science.gov (United States)

    2012-06-29

    ... substantive changes being made by this rule. The rule makes only two minor changes in terminology in the DD... (44 U.S.C. chapter 35). The impact, however, is negligible, because only minor changes in terminology.../agency systems (e.g., Navy's Global Freight Management- Electronic Transportation Acquisition...

  11. Land distribution and acquisition practices in Ghana’s cocoa frontier: The impact of a state-regulated marketing system

    DEFF Research Database (Denmark)

    Knudsen, Michael Helt; Fold, Niels

    2010-01-01

    Substantial differences in the size of landholdings among cocoa farmers in the Western Region – the last cocoa “frontier” in Ghana – are primarily a result of inheritance practices and the purchase of vast tracts of land by migrants in the initial period of the cocoa boom. Individual accumulation...... surplus from their higher volume of cocoa production into investments in non-farm activities and construction of new residential houses—and not in land acquisition based on market transactions. State regulation of the cocoa sector has spurred increased efficiency among private cocoa purchasing companies...

  12. 77 FR 55475 - Federal Acquisition Regulation; Information Collection; Permits, Authorities, or Franchises

    Science.gov (United States)

    2012-09-10

    ... Regulation; Information Collection; Permits, Authorities, or Franchises AGENCY: Department of Defense (DOD... previously approved information collection requirement concerning permits, authorities, or franchises for..., Permits, Authorities, or Franchises, by any of the following methods: Regulations.gov :...

  13. 77 FR 51804 - Federal Acquisition Regulation; Information Collection; Change Order Accounting

    Science.gov (United States)

    2012-08-27

    ... Regulation; Information Collection; Change Order Accounting AGENCY: Department of Defense (DOD), General... collection requirement concerning change order accounting. Public comments are particularly invited on... Collection 9000- 0026, Change Order Accounting by any of the following methods: Regulations.gov :...

  14. 77 FR 45612 - Federal Acquisition Regulation; Information Collection; Professional Employee Compensation Plan

    Science.gov (United States)

    2012-08-01

    ... Regulation; Information Collection; Professional Employee Compensation Plan AGENCY: Department of Defense... Compensation Plan. Public comments are particularly invited on: Whether this collection of information is..., Professional Employee Compensation Plan by any of the following methods: Regulations.gov :...

  15. 78 FR 12755 - Federal Acquisition Regulation; Submission for OMB Review; Schedules for Construction Contracts

    Science.gov (United States)

    2013-02-25

    ... Regulation; Submission for OMB Review; Schedules for Construction Contracts AGENCY: Department of Defense... collection requirement concerning schedules for construction contracts. A notice was published in the Federal..., Schedules for Construction Contracts by any of the following methods: Regulations.gov :...

  16. 78 FR 25445 - Federal Acquisition Regulation; Submission for OMB Review; Quality Assurance Requirements

    Science.gov (United States)

    2013-05-01

    ... Regulation; Submission for OMB Review; Quality Assurance Requirements AGENCY: Department of Defense (DOD... information collection requirement concerning quality assurance requirements. A notice was published in the..., Quality Assurance Requirements, by any of the following methods: Regulations.gov : http://www.regulations...

  17. Getting Back to the Woods: Familial Perspectives on Culture and Preschoolers' Acquisition of Self-Regulation and Emotion Regulation

    Science.gov (United States)

    Boyer, Wanda

    2013-01-01

    Discourse on culture is vital to early childhood educators' understanding of the young child in various socio-cultural experiences in family and community settings. In this article, the author will present a contemporary definition of culture. This article will then discuss the developmental constructs of self-regulation and emotion regulation and…

  18. Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.

    Science.gov (United States)

    Yakar, Shoshana; Isaksson, Olle

    2016-06-01

    The growth hormone (GH) and its downstream mediator, the insulin-like growth factor-1 (IGF-1), construct a pleotropic axis affecting growth, metabolism, and organ function. Serum levels of GH/IGF-1 rise during pubertal growth and associate with peak bone acquisition, while during aging their levels decline and associate with bone loss. The GH/IGF-1 axis was extensively studied in numerous biological systems including rodent models and cell cultures. Both hormones act in an endocrine and autocrine/paracrine fashion and understanding their distinct and overlapping contributions to skeletal acquisition is still a matter of debate. GH and IGF-1 exert their effects on osteogenic cells via binding to their cognate receptor, leading to activation of an array of genes that mediate cellular differentiation and function. Both hormones interact with other skeletal regulators, such as sex-steroids, thyroid hormone, and parathyroid hormone, to facilitate skeletal growth and metabolism. In this review we summarized several rodent models of the GH/IGF-1 axis and described key experiments that shed new light on the regulation of skeletal growth by the GH/IGF-1 axis.

  19. The HHS-HCC Risk Adjustment Model for Individual and Small

    Data.gov (United States)

    U.S. Department of Health & Human Services — Volume 4, Issue 3 of the Medicare and Medicaid Research Review includes three articles describing the Department of Health and Human Services (HHS) developed risk...

  20. 45 CFR 74.12 - Forms for applying for HHS financial assistance.

    Science.gov (United States)

    2010-10-01

    ... Single Point of Contact (SPOC). The name and address of the SPOC for a particular State can be obtained from the HHS awarding agency or the Catalog of Federal Domestic Assistance. The SPOC shall advise...

  1. The System of Public Acquisitions by Means of Electronic Bids in the Light of European Regulations

    Directory of Open Access Journals (Sweden)

    Constantin Roman

    2007-01-01

    Full Text Available E-commerce can lead in many different ways to cost reduction in case of a supplier and can subsequently increase the competition potential of a company. As for the competition mechanism, such changes produce significant modifications within a market economy. The Internet renders the possibility of creating business contacts in a rapid and geographically independent manner, as well as possibilities of obtaining data and realizing transactions within the world's economy. Public acquisitions by means of dynamic systems and electronic bids are currently one of the significant areas of electronic commerce.

  2. The System of Public Acquisitions by Means of Electronic Bids in the Light of European Regulations

    Directory of Open Access Journals (Sweden)

    Costantin Roman

    2007-01-01

    Full Text Available E-commerce can lead in many different ways to cost reduction in case of a supplier and can subsequently increase the competition potential of a company. As for the competition mechanism, such changes produce significant modifications within a market economy. The Internet renders the possibility of creating business contacts in a rapid and geographically independent manner, as well as possibilities of obtaining data and realizing transactions within the world’s economy. Public acquisitions by means of dynamic systems and electronic bids are currently one of the significant areas of electronic commerce.

  3. 78 FR 6188 - Federal Acquisition Regulation; Free Trade Agreement-Colombia

    Science.gov (United States)

    2013-01-29

    ... Regulation; Free Trade Agreement--Colombia AGENCY: Department of Defense (DoD), General Services... Regulation (FAR) to implement the United States-Colombia Trade Promotion Agreement. This Trade Promotion... eligible products and services from Colombia. DATES: Effective Date: January 29, 2013. FOR...

  4. 76 FR 9714 - Defense Federal Acquisition Regulation Supplement; Passive Radio Frequency Identification (DFARS...

    Science.gov (United States)

    2011-02-22

    ...D Supply Chain Materiel Management Regulation, AP1.1.11: (i) Subclass of Class I--Packaged... supply, as defined in DoD 4140.1-R, DoD Supply Chain Materiel Management Regulation, AP1.1.11: (A... INFORMATION: I. Background This DFARS case was initiated at the request of the Office of Logistics...

  5. 76 FR 18304 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Science.gov (United States)

    2011-04-01

    ... implement the Small Business Administration's regulations establishing the Women-Owned Small Business... Business Administration (SBA) regulations at 13 CFR part 127, entitled ``Women-Owned Small Business Federal... business concerns, including women-owned small business (WOSB) concerns and economically......

  6. 77 FR 12913 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Science.gov (United States)

    2012-03-02

    ... Regulation (FAR) to implement the Small Business Administration's regulations establishing the Women-Owned... in certain industries to economically disadvantaged women-owned small business (EDWOSB) concerns or... Appendix I of the Act amended the Small Business Act to provide for a procurement program for...

  7. 77 FR 29982 - Federal Acquisition Regulation; Submission for OMB Review; Davis Bacon Act-Price Adjustment...

    Science.gov (United States)

    2012-05-21

    ... Regulation; Submission for OMB Review; Davis Bacon Act-Price Adjustment (Actual Method) AGENCY: Department of... previously approved information collection requirement concerning the Davis-Bacon Act price adjustment... Bacon Act-Price Adjustment (Actual Method), by any of the following methods: Regulations.gov :...

  8. 75 FR 3236 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2010-01-20

    ... and the provision at 52.230-5 include pertinent rules and regulations related to the Cost Accounting... Regulation; Submission for OMB Review; Cost Accounting Standards Administration AGENCIES: Department of...-0129). SUMMARY: Under the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35),...

  9. 78 FR 5451 - Federal Acquisition Regulation; Submission for OMB Review; Permits, Authorities, or Franchises

    Science.gov (United States)

    2013-01-25

    ... Regulation; Submission for OMB Review; Permits, Authorities, or Franchises AGENCIES: Department of Defense... previously approved information collection requirement concerning permits, authorities, or franchises for... 9000- 0053, Permits, Authorities, or Franchises, by any of the following methods:...

  10. 77 FR 67366 - Federal Acquisition Regulation; Information Collection; Quality Assurance Requirements

    Science.gov (United States)

    2012-11-09

    ... Regulation; Information Collection; Quality Assurance Requirements AGENCY: Department of Defense (DOD... information collection requirement concerning quality assurance requirements. Public comments are particularly... Information Collection 9000- 0077, Quality Assurance Requirements, by any of the following methods...

  11. 75 FR 41486 - Federal Acquisition Regulation; Information Collection; Reporting Purchases From Sources Outside...

    Science.gov (United States)

    2010-07-16

    ... Regulation; Information Collection; Reporting Purchases From Sources Outside the United States AGENCY... and approve an extension of a currently approved information collection requirement concerning reporting purchases from sources outside the United States. Public comments are particularly invited on...

  12. 77 FR 69441 - Federal Acquisition Regulation; Information Collection; Cost Accounting Standards Administration

    Science.gov (United States)

    2012-11-19

    ... Regulation; Information Collection; Cost Accounting Standards Administration AGENCY: Department of Defense... approved information collection requirement concerning cost accounting standards administration. Public... comments identified by Information Collection 9000- 0129, Cost Accounting Standards Administration by...

  13. 77 FR 66464 - Federal Acquisition Regulation; Submission for OMB Review; Value Engineering Requirements

    Science.gov (United States)

    2012-11-05

    ... Regulation; Submission for OMB Review; Value Engineering Requirements AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Value Engineering Requirements. A notice was...: Submit comments identified by Information Collection 9000- 0027, Value Engineering Requirements, by...

  14. 77 FR 43076 - Federal Acquisition Regulation; Information Collection; Value Engineering Requirements

    Science.gov (United States)

    2012-07-23

    ... Regulation; Information Collection; Value Engineering Requirements AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Value Engineering Requirements. Public comments are...: Submit comments identified by Information Collection 9000- 0027, Value Engineering Requirements, by...

  15. 77 FR 70780 - Federal Acquisition Regulation; Submission for OMB Review; Contractors Performing Private...

    Science.gov (United States)

    2012-11-27

    ... Regulation; Submission for OMB Review; Contractors Performing Private Security Functions Outside the United... 9000-0184, Contractors Performing Private Security Functions Outside the United States''. Follow the... ``Information Collection 9000-0184, Contractors Performing Private Security Functions Outside the United...

  16. 78 FR 66740 - Federal Acquisition Regulation; Submission for OMB Review; Patents

    Science.gov (United States)

    2013-11-06

    ... Regulation; Submission for OMB Review; Patents AGENCIES: Department of Defense (DOD), General Services... requirement concerning patents. DATES: Submit comments on or before December 6, 2013. ADDRESSES: Submit comments identified by Information Collection 9000- 0096, Patents, by any of the following...

  17. 75 FR 58388 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--Quarterly... an extension of a currently approved information collection requirement concerning the American Recovery and Reinvestment Act--Quarterly Reporting for Prime Contractors. Public comments are...

  18. 75 FR 58387 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--One-Time... an extension of a currently approved information collection requirement concerning the American Recovery and Reinvestment Act-Reporting Requirements--One Time- Reporting, Compensation...

  19. 78 FR 54250 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2013-09-03

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--Quarterly... Information Collection 9000- 0169, American Recovery and Reinvestment Act--Quarterly Reporting for Prime... Comment'' that corresponds with ``Information Collection 9000-0169, American Recovery and Reinvestment...

  20. 76 FR 9680 - Defense Federal Acquisition Regulation Supplement; Repeal of the Small Business Competitiveness...

    Science.gov (United States)

    2011-02-22

    ... Regulation Supplement; Repeal of the Small Business Competitiveness Demonstration Program (DFARS Case 2011... Competitiveness Demonstration Program. DATES: Effective Date: February 22, 2011. FOR FURTHER INFORMATION CONTACT....S.C. 644 note). The repeal of the Small Business Competitiveness Demonstration Program...

  1. 77 FR 43077 - Federal Acquisition Regulation; Information Collection; Economic Purchase Quantity-Supplies

    Science.gov (United States)

    2012-07-23

    ... Regulation; Information Collection; Economic Purchase Quantity--Supplies AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Economic Purchase Quantity--Supplies. Public...: Submit comments identified by Information Collection 9000- 0082, Economic Purchase Quantity--Supplies, by...

  2. 77 FR 51783 - Federal Acquisition Regulation; Information Collection; Contractors' Purchasing Systems Reviews

    Science.gov (United States)

    2012-08-27

    ... Regulation; Information Collection; Contractors' Purchasing Systems Reviews AGENCY: Department of Defense... previously approved information collection requirement concerning contractors' purchasing systems reviews...: Submit comments identified by Information Collection 9000- 0132, Contractors' Purchasing Systems Reviews...

  3. 77 FR 20012 - Federal Acquisition Regulation; Information Collection; Corporate Aircraft Costs

    Science.gov (United States)

    2012-04-03

    ...., destination, passenger name, purpose of trip, etc.). This information, as required by FAR 31.205-46, Travel... Regulation; Information Collection; Corporate Aircraft Costs AGENCY: Department of Defense (DOD),...

  4. 76 FR 20351 - Federal Acquisition Regulation; Information Collection; Architect-Engineer Qualifications (SF 330)

    Science.gov (United States)

    2011-04-12

    ... Regulation; Information Collection; Architect-Engineer Qualifications (SF 330) AGENCIES: Department of... the Architect-Engineer Qualifications form (SF 330). Public comments are particularly invited on..., Architect-Engineer Qualifications (SF 330), in all correspondence. Dated: April 4, 2011. Millisa...

  5. 76 FR 81942 - Federal Acquisition Regulation; Information Collection; Progress Payments (SF-1443)

    Science.gov (United States)

    2011-12-29

    ... Regulation; Information Collection; Progress Payments (SF-1443) AGENCIES: Department of Defense (DOD... ``Progress Payments,'' contractors are required to request progress payments on Standard Form (SF) 1443... information, reasonably requested by the Contracting Officer. The contractual requirement for submission of...

  6. 77 FR 19287 - Federal Acquisition Regulation; Submission for OMB Review; Progress Payments (SF-1443)

    Science.gov (United States)

    2012-03-30

    ... Register at 76 FR 81942, on December 29, 2011. No comments were received. Public comments are particularly... Regulation; Submission for OMB Review; Progress Payments (SF-1443) AGENCY: Department of Defense...

  7. 77 FR 66466 - Federal Acquisition Regulation; Submission for OMB Review; Notice of Radioactive Materials

    Science.gov (United States)

    2012-11-05

    ... Regulation; Submission for OMB Review; Notice of Radioactive Materials AGENCY: Department of Defense (DOD... approved information collection requirement concerning Notice of Radioactive Materials. A notice was...: Submit comments identified by Information Collection 9000- 0107, Notice of Radioactive Materials, by...

  8. 77 FR 45612 - Federal Acquisition Regulation; Information Collection; Notice of Radioactive Materials

    Science.gov (United States)

    2012-08-01

    ... Regulation; Information Collection; Notice of Radioactive Materials AGENCY: Department of Defense (DOD... approved information collection requirement concerning Notice of Radioactive Materials. Public comments are... comments identified by Information Collection 9000- 0107, Notice of Radioactive Materials, by any of...

  9. 78 FR 23935 - Federal Acquisition Regulation; Information Collection; Contractor Use of Interagency Fleet...

    Science.gov (United States)

    2013-04-23

    ... Regulation; Information Collection; Contractor Use of Interagency Fleet Management System Vehicles AGENCY... previously approved information collection requirement concerning contractor use of interagency fleet... Collection 9000- 0032, Contractor Use of Interagency Fleet Management System Vehicles, by any of...

  10. 77 FR 43077 - Federal Acquisition Regulation; Information Collection; North Carolina Sales Tax Certification

    Science.gov (United States)

    2012-07-23

    ... Regulation; Information Collection; North Carolina Sales Tax Certification AGENCY: Department of Defense (DOD... approved information collection requirement concerning North Carolina sales tax certification. Public...: Submit comments identified by Information Collection 9000- 0059, North Carolina Sales Tax...

  11. 77 FR 73659 - Federal Acquisition Regulation; Information Collection; Schedules for Construction Contracts

    Science.gov (United States)

    2012-12-11

    ... Regulation; Information Collection; Schedules for Construction Contracts AGENCIES: Department of Defense (DOD... previously approved information collection requirement concerning schedules for construction contracts...: Submit comments identified by Information Collection 9000- 0058, Schedules for Construction Contracts...

  12. 78 FR 22841 - Defense Federal Acquisition Regulation Supplement: Encouragement of Science, Technology...

    Science.gov (United States)

    2013-04-17

    ... Regulation Supplement: Encouragement of Science, Technology, Engineering, and Mathematics (STEM) Programs... contractors to develop science, technology, engineering, and mathematics (STEM) programs. FOR FURTHER... 2012, which requires DoD to encourage contractors to develop science, technology, engineering,...

  13. 76 FR 37353 - Federal Acquisition Regulation; Submission for OMB Review; Contractor Business Ethics Compliance...

    Science.gov (United States)

    2011-06-27

    ... Regulation; Submission for OMB Review; Contractor Business Ethics Compliance Program and Disclosure... requirement concerning contractor business ethics compliance program and disclosure requirements. Public... Information Collection 9000- 0164, Contractor Business Ethics Compliance Program and Disclosure...

  14. 76 FR 60837 - Federal Acquisition Regulation; Information Collection; Contractor Business Ethics Compliance...

    Science.gov (United States)

    2011-09-30

    ... Regulation; Information Collection; Contractor Business Ethics Compliance Program and Disclosure Requirements... concerning contractor business ethics compliance program and disclosure requirements. Public comments are... Collection 9000- 0164, Contractor Business Ethics Compliance Program and Disclosure Requirements, by any...

  15. 78 FR 17404 - Federal Acquisition Regulation; Submission for OMB Review; Extraordinary Contractual Action Requests

    Science.gov (United States)

    2013-03-21

    ... change to http://www.regulations.gov , including any personal and/or business confidential information... agency did not accurately estimate the public burden challenging that the agency's methodology for... public. This is evidenced, as the respondent notes, in FAR Case 2007-006 where an adjustment was made...

  16. 78 FR 38341 - Federal Acquisition Regulation; Information Collection; Preaward Survey Forms (Standard Forms...

    Science.gov (United States)

    2013-06-26

    ... change to http://www.regulations.gov , including any personal and/or business confidential information...) necessary to determine contractor responsibility in each case. B. Annual Reporting Burden There are no... burden of this collection of information is accurate, and based on valid assumptions and methodology...

  17. 78 FR 56230 - Federal Acquisition Regulation; Information Collection; Reporting Purchases From Sources Outside...

    Science.gov (United States)

    2013-09-12

    ... Regulation; Information Collection; Reporting Purchases From Sources Outside the United States AGENCY... request to review and approve an extension of a currently approved information collection requirement concerning reporting purchases from sources outside the United States. DATES: Submit comments on or before...

  18. 77 FR 35661 - Federal Acquisition Regulation; Information Collection; Evaluation of Export Offers

    Science.gov (United States)

    2012-06-14

    ... Regulation; Information Collection; Evaluation of Export Offers AGENCIES: Department of Defense (DOD... include your name, company name (if any), and ``Information Collection 9000-0057, Evaluation of Export... approved information collection requirement concerning the provision at FAR 52.247-51,...

  19. 78 FR 37692 - Federal Acquisition Regulation; Contracting With Women-Owned Small Business Concerns

    Science.gov (United States)

    2013-06-21

    ... Regulation; Contracting With Women-Owned Small Business Concerns AGENCY: Department of Defense (DoD), General... small business concerns and to women-owned small business concerns eligible under the Women-owned Small... ] Women-owned Small Business Concerns, which is the statutory authority for SBA's......

  20. 78 FR 18877 - Defense Federal Acquisition Regulation Supplement: New Free Trade Agreement With Colombia (DFARS...

    Science.gov (United States)

    2013-03-28

    ... Regulation Supplement: New Free Trade Agreement With Colombia (DFARS Case 2012-D032) AGENCY: Defense... (DFARS) to implement the United States-Colombia Trade Promotion Agreement. This Trade Promotion Agreement is a free trade agreement that provides for mutually non-discriminatory treatment of eligible...

  1. 77 FR 69723 - Federal Acquisition Regulation; Free Trade Agreement-Panama

    Science.gov (United States)

    2012-11-20

    ... Regulation; Free Trade Agreement--Panama AGENCIES: Department of Defense (DoD), General Services... implement the United States-- Panama Trade Promotion Agreement. This Trade Promotion Agreement is a free... Promotion Agreement is designated in the FAR as the Panama Free Trade Agreement (FTA). This FTA provides for...

  2. 78 FR 18876 - Defense Federal Acquisition Regulation Supplement: United States-Korea Free Trade Agreement...

    Science.gov (United States)

    2013-03-28

    ... Regulation Supplement: United States- Korea Free Trade Agreement (DFARS Case 2012-D025) AGENCY: Defense... (DFARS) to implement the United States-Korea Free Trade Agreement. The Republic of Korea is already party..., 2012, to implement the United States-Korea Free Trade Agreement (see the United States-Korea Free Trade...

  3. 77 FR 56739 - Federal Acquisition Regulation; United States-Korea Free Trade Agreement

    Science.gov (United States)

    2012-09-13

    ... States-Korea Free Trade Agreement AGENCY: Department of Defense (DoD), General Services Administration... Regulation (FAR) to implement the United States-Korea Free Trade Agreement. The Republic of Korea is already... the Republic of Korea to the definition of ``Free Trade Agreement country'' in multiple locations in...

  4. 77 FR 30355 - Defense Federal Acquisition Regulation Supplement: United States-Korea Free Trade Agreement...

    Science.gov (United States)

    2012-05-22

    ... Regulation Supplement: United States- Korea Free Trade Agreement (DFARS Case 2012-D025) AGENCY: Defense... United States-Korea Free Trade Agreement. The Republic of Korea is already party to the World Trade... provisions and clauses in DFARS part 252 to implement the United States-Korea Free Trade Agreement (see the...

  5. 77 FR 43081 - Federal Acquisition Regulation; Information Collection; Buy American Act-Free Trade Agreements...

    Science.gov (United States)

    2012-07-23

    ... Regulation; Information Collection; Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate... previously approved information collection requirement concerning the Buy American Act--Free Trade Agreements..., Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate, by any of the following...

  6. 78 FR 72620 - Federal Acquisition Regulation; Higher-Level Contract Quality Requirements

    Science.gov (United States)

    2013-12-03

    ... posted without change to http://www.regulations.gov , including any personal and/or business confidential... counterfeit electronic parts. However, because of the globalization of the marketplace, the problem of... and industry. Globalization in the marketplace increased the risk of counterfeit items in...

  7. 75 FR 8362 - Federal Acquisition Regulation; Submission for OMB Review; Patents

    Science.gov (United States)

    2010-02-24

    ... Regulation; Submission for OMB Review; Patents AGENCY: Department of Defense (DOD), General Services... approved information collection requirement concerning patents. A request for public ] comments was..., GSA (202) 501-3775 or e-mail ernest.woodson@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose The...

  8. 78 FR 23194 - Federal Acquisition Regulation; Commercial and Government Entity Code

    Science.gov (United States)

    2013-04-18

    ... registration is not required, a CAGE code will be requested and obtained from the Defense Logistics Agency, Logistics Information Service. A CAGE code is not required when a condition described at FAR 4.605(c)(2... assess all costs and benefits of available regulatory alternatives and, if regulation is necessary, to...

  9. 77 FR 75766 - Federal Acquisition Regulation; Nondisplacement of Qualified Workers Under Service Contracts

    Science.gov (United States)

    2012-12-21

    ... DOL implementing regulations. For clarity, a definition of ``service employee'' was added, and the... the SCA. The definition of ``service employee'' at 41 U.S.C. 6701(3) provides, in part, that it ``does... construction equipment.'' The definition of ``service employee'' addresses this concept. Therefore, FAR...

  10. 78 FR 54650 - Federal Acquisition Regulation; Information Collection American Recovery and Reinvestment Act...

    Science.gov (United States)

    2013-09-05

    ... Regulation; Information Collection American Recovery and Reinvestment Act-Reporting Requirements--One-Time... comments identified by Information Collection 9000- 0167, American Recovery and Reinvestment Act-Reporting.... Instructions: Please submit comments only and cite Information Collection 9000-0167, American Recovery...

  11. 75 FR 58389 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--One Time... and approve an extension of a currently approved information collection requirement concerning the American Recovery and Reinvestment Act-Reporting Requirements--One Time Reporting Requirements for...

  12. 78 FR 54648 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2013-09-05

    ... Regulation; Information Collection; American Recovery and Reinvestment Act--Reporting Requirements--One-Time... identified by Information Collection 9000- 0168, American Recovery and Reinvestment Act--Reporting..., company name (if any), and ``Information Collection 9000-0168, American Recovery and Reinvestment...

  13. 75 FR 58390 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--One-Time... extension of a currently approved information collection requirement concerning the American Recovery and... particularly invited on: Whether this collection of information is necessary for the proper performance...

  14. 78 FR 18342 - Federal Acquisition Regulation; Submission for OMB Review; Change Order Accounting

    Science.gov (United States)

    2013-03-26

    ... Regulation; Submission for OMB Review; Change Order Accounting AGENCY: Department of Defense (DOD), General... collection requirement concerning change order accounting. A notice was published in the Federal Register at... Information Collection 9000- 0026, Change Order Accounting, by any of the following methods:...

  15. 75 FR 6669 - Federal Acquisition Regulation; Submission for OMB Review; Contractors' Purchasing Systems Reviews

    Science.gov (United States)

    2010-02-10

    ... contractors' purchasing systems reviews. A request for public comments was published in the Federal Register....cundiff@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose The objective of a contractor purchasing system... Regulation; Submission for OMB Review; Contractors' Purchasing Systems Reviews AGENCIES: Department of...

  16. 78 FR 38340 - Federal Acquisition Regulation; Submission for OMB Review; Right of First Refusal of Employment

    Science.gov (United States)

    2013-06-26

    ... Regulation; Submission for OMB Review; Right of First Refusal of Employment AGENCY: Department of Defense...: Submit comments identified by Information Collection 9000- 0114, Right of First Refusal of Employment, by... corresponds with ``Information Collection 9000-0114, Right of First Refusal of Employment''. Follow...

  17. 78 FR 17670 - Federal Acquisition Regulation; Information Collection; Right of First Refusal of Employment

    Science.gov (United States)

    2013-03-22

    ... Regulation; Information Collection; Right of First Refusal of Employment AGENCY: Department of Defense (DoD... comments identified by Information Collection 9000- 0114, Right of First Refusal of Employment, by any of... corresponds with ``Information Collection 9000-0114, Right of First Refusal of Employment''. Follow...

  18. 75 FR 4565 - Federal Acquisition Regulation; Submission for OMB Review; Right of First Refusal of Employment

    Science.gov (United States)

    2010-01-28

    ... Regulation; Submission for OMB Review; Right of First Refusal of Employment AGENCIES: Department of Defense....sakalos@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose Right of First Refusal of Employment is a..., DC 20405, telephone (202) 501-4755. Please cite OMB Control No. 9000-0114, Right of First Refusal...

  19. 77 FR 38736 - Defense Federal Acquisition Regulation Supplement: New Qualifying Country-Czech Republic (DFARS...

    Science.gov (United States)

    2012-06-29

    ... enterprises of the other country to the extent mutually beneficial and consistent with national laws, regulations, policies, and international obligations. The agreement does not cover construction or... meaning of the basic DoD policy on contracting with qualifying country sources. Accordingly, the change...

  20. 76 FR 35219 - Federal Acquisition Regulation; Information Collection; Payment by Electronic Fund Transfer

    Science.gov (United States)

    2011-06-16

    ... Regulation; Information Collection; Payment by Electronic Fund Transfer AGENCY: Department of Defense (DOD... transfer. Public comments are particularly invited on: Whether this collection of information is necessary... those who are to respond, through the use of appropriate technological collection techniques or...

  1. 77 FR 13328 - Federal Acquisition Regulation; Information Collection; Davis Bacon Act-Price Adjustment (Actual...

    Science.gov (United States)

    2012-03-06

    ... Regulation; Information Collection; Davis Bacon Act--Price Adjustment (Actual Method) AGENCY: Department of... previously approved information collection requirement concerning the Davis-Bacon Act price adjustment... comments identified by Information Collection 9000- 0154, Davis Bacon Act--Price Adjustment (Actual...

  2. 76 FR 67153 - Federal Acquisition Regulation; Submission for OMB Review; Payment by Electronic Fund Transfer

    Science.gov (United States)

    2011-10-31

    ... would enable the Government to make payments under the contract by electronic fund transfer (EFT). The... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF DEFENSE... Regulation; Submission for OMB Review; Payment by Electronic Fund Transfer AGENCY: Department of Defense (DOD...

  3. 75 FR 13764 - Federal Acquisition Regulation; Information Collection; Rights in Data and Copyrights

    Science.gov (United States)

    2010-03-23

    ... only when the very nature of the contractor's work is comprised of limited rights data or restricted... Regulation; Information Collection; Rights in Data and Copyrights AGENCIES: Department of Defense (DOD... extension of a previously approved information collection requirement concerning rights in data and...

  4. 75 FR 9604 - Federal Acquisition Regulation; Submission for OMB Review; Subcontracting Plans/Individual...

    Science.gov (United States)

    2010-03-03

    ... subcontracting plans/individual subcontract report. A request for public comments published in the Federal Register at 73 FR 21779 on April 22, 2008. No comments were received. Public comments are particularly... Regulation; Submission for OMB Review; Subcontracting Plans/Individual Subcontract Report...

  5. 77 FR 69626 - Federal Acquisition Regulation; Information Collection; Subcontracting Plans/Individual...

    Science.gov (United States)

    2012-11-20

    ... regarding an extension to this clearance published in the Federal Register at 75 FR 9604, on March 3, 2010... Regulation; Information Collection; Subcontracting Plans/Individual Subcontract Report (SF-294) AGENCIES... previously approved information collection requirement concerning subcontracting plans/individual...

  6. 78 FR 5452 - Federal Acquisition Regulation; Submission for OMB Review; Qualification Requirements

    Science.gov (United States)

    2013-01-25

    ... award of a contract. Under the qualification requirements, an end item, or a component thereof, may be... offeror before award of a contract. Under the qualification requirements, an end item, or a component... Regulation; Submission for OMB Review; Qualification Requirements AGENCIES: Department of Defense...

  7. 76 FR 58155 - Defense Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Services...

    Science.gov (United States)

    2011-09-20

    ... Regulation Supplement; Construction and Architect-Engineer Services Performance Evaluation (DFARS Case 2010... construction and architect-engineer services. DATES: Effective Date: September 20, 2011. FOR FURTHER... construction and Architect- Engineer services. On April 19, 2011, DoD published a proposed rule in the...

  8. 76 FR 21851 - Defense Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Services...

    Science.gov (United States)

    2011-04-19

    ... Regulation Supplement; Construction and Architect-Engineer Services Performance Evaluation (DFARS Case 2010... construction and architect-engineer services. DATES: Comments on the proposed rule should be submitted in... requirement to use DoD-unique forms to document contractor past performance for construction and...

  9. 78 FR 73450 - Defense Federal Acquisition Regulation Supplement: Preparation of Letter of Offer and Acceptance...

    Science.gov (United States)

    2013-12-06

    ... Regulation Supplement: Preparation of Letter of Offer and Acceptance (DFARS Case 2012-D048) AGENCY: Defense... of ] the letter of offer and acceptance for a foreign military sales program that will require an... activity in preparing the letter of offer and acceptance for a foreign military sales program that...

  10. 78 FR 28793 - Defense Federal Acquisition Regulation Supplement: Preparation of Letter of Offer and Acceptance...

    Science.gov (United States)

    2013-05-16

    ... Regulation Supplement: Preparation of Letter of Offer and Acceptance (DFARS Case 2012-D048) AGENCY: Defense... officer role in assisting the DoD implementing agency in preparation of the letter of offer and acceptance... to assist the DoD implementing activity in preparing the letter of offer and acceptance for a...

  11. 75 FR 34942 - Defense Federal Acquisition Regulation Supplement; Multiyear Contract Authority for Electricity...

    Science.gov (United States)

    2010-06-21

    ... Regulation Supplement; Multiyear Contract Authority for Electricity From Renewable Energy Sources (DFARS Case... enter into a contract for a period not to exceed 10 years for the purchase of electricity from sources... electricity from sources of renewable energy, as that term is defined in section 203(b)(2) of the Energy...

  12. 76 FR 14587 - Defense Federal Acquisition Regulation Supplement; Multiyear Contract Authority for Electricity...

    Science.gov (United States)

    2011-03-17

    ... Regulation Supplement; Multiyear Contract Authority for Electricity From Renewable Energy Sources (DFARS Case... Defense to enter into a contract for a period not to exceed 10 years for the purchase of electricity from... prepared by DoD, that-- (1) The proposed purchase of electricity under such contract is cost effective; and...

  13. 76 FR 55389 - Federal Acquisition Regulation; Submission for OMB Review; Architect-Engineer Qualifications (SF...

    Science.gov (United States)

    2011-09-07

    ... Register at 76 FR 20351, on April 12, 2011. One comment was received. General Comment A respondent... Regulation; Submission for OMB Review; Architect-Engineer Qualifications (SF 330) AGENCIES: Department of... Architect-Engineer Qualifications form (SF 330). Public comments are particularly invited on: Whether...

  14. 78 FR 69086 - Federal Acquisition Regulation; Submission for OMB Review; Preaward Survey Forms (Standard Forms...

    Science.gov (United States)

    2013-11-18

    ... will be posted without change to http://www.regulations.gov , including any personal and/or business... Forms 1403, 1404, 1405, 1406, 1407, and 1408 in detail commensurate with the dollar value and complexity... Government that bears the burden of the effort. The Government's work in conducting a preaward survey is not...

  15. 77 FR 54872 - Federal Acquisition Regulation; Prioritizing Sources of Supplies and Services for Use by the...

    Science.gov (United States)

    2012-09-06

    ... consideration to using certain existing non-mandatory sources to leverage agency buying power and achieve... posted without change to http://www.regulations.gov , including any personal and/or business confidential... INFORMATION: DoD, GSA, and NASA published a proposed rule in the Federal Register at 76 FR 34634 on June...

  16. 78 FR 64499 - Federal Acquisition Regulation; Submission for OMB Review; Contractor Use of Interagency Fleet...

    Science.gov (United States)

    2013-10-29

    ... management system vehicles. A notice was published in the Federal Register at 78 FR 23935, on April 23, 2013... Register on March 5, 2010 (75 FR 10267). No public comments were received in prior years that have... Regulation; Submission for OMB Review; Contractor Use of Interagency Fleet Management System Vehicles...

  17. 77 FR 66844 - Federal Acquisition Regulation; Submission for OMB Review; Evaluation of Export Offers

    Science.gov (United States)

    2012-11-07

    ... ``Evaluation of Export Offers.'' A notice was published in the Federal Register at 77 FR 35661, on June 14... Regulation; Submission for OMB Review; Evaluation of Export Offers AGENCIES: Department of Defense (DOD... the use of appropriate technological collection techniques or other forms of information...

  18. 75 FR 70263 - Federal Acquisition Regulation; Submission for OMB Review; Reporting Purchases From Sources...

    Science.gov (United States)

    2010-11-17

    ... Regulation; Submission for OMB Review; Reporting Purchases From Sources Outside the United States AGENCY... reporting purchases from sources outside the United States. Public comments are particularly invited on... technological collection techniques or other forms of information technology. DATES: Submit comments on...

  19. 76 FR 37353 - Federal Acquisition Regulation; Information Collection; Certification of Independent Price...

    Science.gov (United States)

    2011-06-27

    ... valid assumptions and methodology; ways to enhance the quality, utility, and clarity of the information... ``Information Collection 9000-0018'' under the heading ``Enter Keyword or ID'' and selecting ``Search''. Select... Regulation; Information Collection; Certification of Independent Price Determination and Parent Company...

  20. 78 FR 13675 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2013-02-28

    ... accounting practice change, the total potential impact of the change on contracts containing a CAS provision... Regulation; Submission for OMB Review; Cost Accounting Standards Administration AGENCY: Department of Defense...: Under the provisions of the Paperwork Reduction Act, the Regulatory Secretariat will be submitting...

  1. 77 FR 19126 - Defense Federal Acquisition Regulation Supplement: New Threshold for Peer Reviews of...

    Science.gov (United States)

    2012-03-30

    ... Regulation Supplement: New Threshold for Peer Reviews of Noncompetitive Contracts (DFARS Case 2012-D018... modify the threshold for noncompetitive contract peer reviews. DATES: Effective Date: April 30, 2012. FOR.... Background This final rule reduces the threshold for DoD peer reviews of noncompetitive contracts from...

  2. 77 FR 10461 - Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor Excise...

    Science.gov (United States)

    2012-02-22

    ....regulations.gov , including any personal and/or business confidential information provided. FOR FURTHER... effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance of quantifying both costs..., Regulatory Planning and Review, dated September 30, 1993. This rule is not a major rule under 5 U.S.C....

  3. 78 FR 60169 - Federal Acquisition Regulation; Pilot Program for Enhancement of Contractor Employee...

    Science.gov (United States)

    2013-09-30

    ...://www.regulations.gov , including any personal and/or business confidential information provided. FOR... equity). E.O. 13563 emphasizes the importance of quantifying both costs and benefits, of reducing costs..., therefore, was subject to review under section 6(b) of E.O. 12866, Regulatory Planning and Review,...

  4. 77 FR 27547 - Federal Acquisition Regulation; Prohibition on Contracting With Inverted Domestic Corporations

    Science.gov (United States)

    2012-05-10

    ... be posted without change to http://www.regulations.gov , including any personal and/or business..., public health and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance... section 6(b) of E.O. 12866, Regulatory Planning and Review, dated September 30, 1993. This rule is not...

  5. 76 FR 42127 - Federal Acquisition Regulation; Submission for OMB Review; Place of Performance

    Science.gov (United States)

    2011-07-18

    ..., company name (if any), and ``Information Collection 9000-0047 Place of Performance'' on your attached... place of performance and owner of plant or facility, if other than the prospective contractor, is a... Regulation; Submission for OMB Review; Place of Performance AGENCY: Department of Defense (DOD), General...

  6. 78 FR 13604 - Defense Federal Acquisition Regulation Supplement: Encouragement of Science, Technology...

    Science.gov (United States)

    2013-02-28

    ... Regulation Supplement: Encouragement of Science, Technology, Engineering, and Mathematics (STEM) Programs..., which requires DoD to take steps to encourage contractors to develop science, technology, engineering... (FY12), which requires DoD to encourage contractors to develop science, technology, engineering,...

  7. 78 FR 45198 - Federal Acquisition Regulation; Submission for OMB Review; Anti-Kickback Procedures

    Science.gov (United States)

    2013-07-26

    ..., Contractor Business Ethics Compliance Program and Disclosure Requirements. Response: It is important to... business. In the normal course of business, a company that is concerned about ethical behavior will take....regulations.gov , including any personal and/or business confidential information provided. FOR...

  8. 77 FR 51026 - Federal Acquisition Regulation; Submission for OMB Review; Government Property

    Science.gov (United States)

    2012-08-23

    ... Regulation; Submission for OMB Review; Government Property AGENCY: Department of Defense (DOD), General... collection requirement concerning Government Property. A notice was published in the Federal Register at 76...) 501-1448 or email curtis.glover@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose Property, as used...

  9. 76 FR 49483 - Federal Acquisition Regulation; Information Collection; Organization and Direction of Work

    Science.gov (United States)

    2011-08-10

    ... Regulation; Information Collection; Organization and Direction of Work AGENCY: Department of Defense (DOD... extension of a previously approved information collection requirement concerning organization and direction... comments identified by Information Collection 9000- 0064, Organization and Direction of Work, by any of the...

  10. Acquisition of anoikis resistance up-regulates syndecan-4 expression in endothelial cells.

    Directory of Open Access Journals (Sweden)

    Bruna Ribeiro Carneiro

    Full Text Available Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix, behaving as a critical mechanism in preventing adherent-independent cell growth and attachment to an inappropriate matrix, thus avoiding colonization of distant organs. Cell adhesion plays an important role in neoplastic transformation. Tumors produce several molecules that facilitate their proliferation, invasion and maintenance, especially proteoglycans. The syndecan-4, a heparan sulfate proteoglycan, can act as a co-receptor of growth factors and proteins of the extracellular matrix by increasing the affinity of adhesion molecules to their specific receptors. It participates together with integrins in cell adhesion at focal contacts connecting the extracellular matrix to the cytoskeleton. Changes in the expression of syndecan-4 have been observed in tumor cells, indicating its involvement in cancer. This study investigates the role of syndecan-4 in the process of anoikis and cell transformation. Endothelial cells were submitted to sequential cycles of forced anchorage impediment and distinct lineages were obtained. Anoikis-resistant endothelial cells display morphological alterations, high rate of proliferation, poor adhesion to fibronectin, laminin and collagen IV and deregulation of the cell cycle, becoming less serum-dependent. Furthermore, anoikis-resistant cell lines display a high invasive potential and a low rate of apoptosis. This is accompanied by an increase in the levels of heparan sulfate and chondroitin sulfate as well as by changes in the expression of syndecan-4 and heparanase. These results indicate that syndecan-4 plays a important role in acquisition of anoikis resistance and that the conferral of anoikis resistance may suffice to transform endothelial cells.

  11. Application of wide selected-ion monitoring data-independent acquisition to identify tomato fruit proteins regulated by the CUTIN DEFICIENT2 transcription factor

    Science.gov (United States)

    We describe here the use of label-free wide selected-ion monitoring data-independent acquisition (WiSIM-DIA) to identify proteins that are involved in the formation of tomato (Solanum lycopersicum) fruit cuticles and that are regulated by the transcription factor CUTIN DEFICIENT2 (CD2). A spectral l...

  12. Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes.

    Science.gov (United States)

    Burke, Thomas P; Loukitcheva, Anastasia; Zemansky, Jason; Wheeler, Richard; Boneca, Ivo G; Portnoy, Daniel A

    2014-11-01

    Listeria monocytogenes is a Gram-positive facultative intracellular pathogen that is highly resistant to lysozyme, a ubiquitous enzyme of the innate immune system that degrades cell wall peptidoglycan. Two peptidoglycan-modifying enzymes, PgdA and OatA, confer lysozyme resistance on L. monocytogenes; however, these enzymes are also conserved among lysozyme-sensitive nonpathogens. We sought to identify additional factors responsible for lysozyme resistance in L. monocytogenes. A forward genetic screen for lysozyme-sensitive mutants led to the identification of 174 transposon insertion mutations that mapped to 13 individual genes. Four mutants were killed exclusively by lysozyme and not other cell wall-targeting molecules, including the peptidoglycan deacetylase encoded by pgdA, the putative carboxypeptidase encoded by pbpX, the orphan response regulator encoded by degU, and the highly abundant noncoding RNA encoded by rli31. Both degU and rli31 mutants had reduced expression of pbpX and pgdA, yet DegU and Rli31 did not regulate each other. Since pbpX and pgdA are also present in lysozyme-sensitive bacteria, this suggested that the acquisition of novel enzymes was not responsible for lysozyme resistance, but rather, the regulation of conserved enzymes by DegU and Rli31 conferred high lysozyme resistance. Each lysozyme-sensitive mutant exhibited attenuated virulence in mice, and a time course of infection revealed that the most lysozyme-sensitive strain was killed within 30 min of intravenous infection, a phenotype that was recapitulated in purified blood. Collectively, these data indicate that the genes required for lysozyme resistance are highly upregulated determinants of L. monocytogenes pathogenesis that are required for avoiding the enzymatic activity of lysozyme in the blood. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  13. MRTF-A signaling regulates the acquisition of the contractile phenotype in dedifferentiated chondrocytes.

    Science.gov (United States)

    Parreno, Justin; Raju, Sneha; Wu, Po-Han; Kandel, Rita A

    2016-10-14

    Chondrocyte culture as a monolayer for cell number expansion results in dedifferentiation whereby expanded cells acquire contractile features and increased actin polymerization status. This study determined whether the actin polymerization based signaling pathway, myocardin-related transcription factor-a (MRTF-A) is involved in regulating this contractile phenotype. Serial passaging of chondrocytes in monolayer culture to passage 2 resulted in increased gene and protein expression of the contractile molecules alpha-smooth muscle actin, transgelin and vinculin compared to non-passaged, primary cells. This resulted in a functional change as passaged 2, but not primary, chondrocytes were capable of contracting type I collagen gels in a stress-relaxed contraction assay. These changes were associated with increased actin polymerization and MRTF-A nuclear localization. The involvement of actin was demonstrated by latrunculin B depolymerization of actin which reversed these changes. Alternatively cytochalasin D which activates MRTF-A increased gene and protein expression of α-smooth muscle actin, transgelin and vinculin, whereas CCG1423 which deactivates MRTF-A decreased these molecules. The involvement of MRTF-A signaling was confirmed by gene silencing of MRTF or its co-factor serum response factor. Knockdown experiments revealed downregulation of α-smooth muscle actin and transgelin gene and protein expression, and inhibition of gel contraction. These findings demonstrate that passaged chondrocytes acquire a contractile phenotype and that this change is modulated by the actin-MRTF-A-serum response factor signaling pathway.

  14. 78 FR 72321 - Patient Protection and Affordable Care Act; HHS Notice of Benefit and Payment Parameters for 2015

    Science.gov (United States)

    2013-12-02

    ... c. Small group determination for risk adjustment d. Risk adjustment data validation e. HHS audits of... may audit State-operated reinsurance programs, contributing entities, and issuers of risk adjustment... to risk adjustment data validation, risk corridors data validation, and HHS's authority to...

  15. 42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.

    Science.gov (United States)

    2010-10-01

    ... research misconduct. 93.411 Section 93.411 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.411 Final HHS action with settlement or...

  16. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Science.gov (United States)

    2010-10-01

    ... research misconduct. 93.410 Section 93.410 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement...

  17. Five Years of HHS Home Health Care Evaluations: Using Evaluation to Change National Policy

    Science.gov (United States)

    Brandon, Paul R.; Smith, Nick L.; Grob, George F.

    2012-01-01

    In 1997, American Evaluation Association member George Grob, now retired from the U.S. Department of Health and Human Services (HHS) and currently President of the Center for Public Program Evaluation, made a testimony on Medicare home health care fraud and abuse before the U.S. Senate Special Committee on Aging. The occasion was to announce the…

  18. 75 FR 28023 - Solicitation of Written Comments on Draft HHS Strategic Framework on Multiple Chronic Conditions

    Science.gov (United States)

    2010-05-19

    ... care, professional, and educational organizations --Physicians, nurses, hospitals, and other health... Strategic Framework. FOR FURTHER INFORMATION CONTACT: Monica L. Stevenson, (202) 401-6998 or MCC@hhs.gov . SUPPLEMENTARY INFORMATION: I. Background Approximately 75 million Americans have multiple (2 or more)...

  19. 76 FR 2383 - Proposed HHS Recommendation for Fluoride Concentration in Drinking Water for Prevention of Dental...

    Science.gov (United States)

    2011-01-13

    ... pharyngeal cancers, and sports-related craniofacial injuries: a report on recommendations of the Task Force... HUMAN SERVICES Proposed HHS Recommendation for Fluoride Concentration in Drinking Water for Prevention... prevention and control across all age groups. Fluoride in drinking water as one of several available fluoride...

  20. FYI:Model Programs Serving Drug Exposed Children...HHS REPORT:"Crack Babies" Released.

    Science.gov (United States)

    Children Today, 1990

    1990-01-01

    Announces Health and Human Services (HHS) report on effects that babies who have been exposed to cocaine are having on child welfare system. Many babies are not identified at birth and may suffer future neurological, developmental, and emotional damage. Child welfare system is trying new approaches to handling children but is hampered by lack of…

  1. Optimization of the Fermentation Process of Actinomycete Strain Hhs.015T

    Directory of Open Access Journals (Sweden)

    Xinxuan Wang

    2010-01-01

    inoculation volume of 15.8%. The antimicrobial activity was increased by 20% by optimizing the environmental parameters. The results obtained allow an efficient production of components with antimicrobial activity by strain Hhs.015T on a large scale at low costs.

  2. 48 CFR 873.105 - Acquisition planning.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquisition planning. 873.105 Section 873.105 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS DEPARTMENT... planning. (a) Acquisition planning is an indispensable component of the total acquisition process. (b) For...

  3. 48 CFR 3034.004 - Acquisition strategy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Acquisition strategy. 3034.004 Section 3034.004 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND... Acquisition strategy. See (HSAR) 48 CFR 3009.570 for policy applicable to acquisition strategies that...

  4. Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.

    Directory of Open Access Journals (Sweden)

    I-Wen Song

    Full Text Available ZDHHC13 is a member of DHHC-containing palmitoyl acyltransferases (PATs family of enzymes. It functions by post-translationally adding 16-carbon palmitate to proteins through a thioester linkage. We have previously shown that mice carrying a recessive Zdhhc13 nonsense mutation causing a Zdhcc13 deficiency develop alopecia, amyloidosis and osteoporosis. Our goal was to investigate the pathogenic mechanism of osteoporosis in the context of this mutation in mice. Body size, skeletal structure and trabecular bone were similar in Zdhhc13 WT and mutant mice at birth. Growth retardation and delayed secondary ossification center formation were first observed at day 10 and at 4 weeks of age, disorganization in growth plate structure and osteoporosis became evident in mutant mice. Serial microCT from 4-20 week-olds revealed that Zdhhc13 mutant mice had reduced bone mineral density. Through co-immunoprecipitation and acyl-biotin exchange, MT1-MMP was identified as a direct substrate of ZDHHC13. In cells, reduction of MT1-MMP palmitoylation affected its subcellular distribution and was associated with decreased VEGF and osteocalcin expression in chondrocytes and osteoblasts. In Zdhhc13 mutant mice epiphysis where MT1-MMP was under palmitoylated, VEGF in hypertrophic chondrocytes and osteocalcin at the cartilage-bone interface were reduced based on immunohistochemical analyses. Our results suggest that Zdhhc13 is a novel regulator of postnatal skeletal development and bone mass acquisition. To our knowledge, these are the first data to suggest that ZDHHC13-mediated MT1-MMP palmitoylation is a key modulator of bone homeostasis. These data may provide novel insights into the role of palmitoylation in the pathogenesis of human osteoporosis.

  5. Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.

    Science.gov (United States)

    Song, I-Wen; Li, Wei-Ru; Chen, Li-Ying; Shen, Li-Fen; Liu, Kai-Ming; Yen, Jeffrey J Y; Chen, Yi-Ju; Chen, Yu-Ju; Kraus, Virginia Byers; Wu, Jer-Yuarn; Lee, M T Michael; Chen, Yuan-Tsong

    2014-01-01

    ZDHHC13 is a member of DHHC-containing palmitoyl acyltransferases (PATs) family of enzymes. It functions by post-translationally adding 16-carbon palmitate to proteins through a thioester linkage. We have previously shown that mice carrying a recessive Zdhhc13 nonsense mutation causing a Zdhcc13 deficiency develop alopecia, amyloidosis and osteoporosis. Our goal was to investigate the pathogenic mechanism of osteoporosis in the context of this mutation in mice. Body size, skeletal structure and trabecular bone were similar in Zdhhc13 WT and mutant mice at birth. Growth retardation and delayed secondary ossification center formation were first observed at day 10 and at 4 weeks of age, disorganization in growth plate structure and osteoporosis became evident in mutant mice. Serial microCT from 4-20 week-olds revealed that Zdhhc13 mutant mice had reduced bone mineral density. Through co-immunoprecipitation and acyl-biotin exchange, MT1-MMP was identified as a direct substrate of ZDHHC13. In cells, reduction of MT1-MMP palmitoylation affected its subcellular distribution and was associated with decreased VEGF and osteocalcin expression in chondrocytes and osteoblasts. In Zdhhc13 mutant mice epiphysis where MT1-MMP was under palmitoylated, VEGF in hypertrophic chondrocytes and osteocalcin at the cartilage-bone interface were reduced based on immunohistochemical analyses. Our results suggest that Zdhhc13 is a novel regulator of postnatal skeletal development and bone mass acquisition. To our knowledge, these are the first data to suggest that ZDHHC13-mediated MT1-MMP palmitoylation is a key modulator of bone homeostasis. These data may provide novel insights into the role of palmitoylation in the pathogenesis of human osteoporosis.

  6. 78 FR 48170 - Privacy Act of 1974; CMS Computer Match No. 2013-12; HHS Computer Match No. 1307; SSA Computer...

    Science.gov (United States)

    2013-08-07

    ... Services Privacy Act of 1974; CMS Computer Match No. 2013-12; HHS Computer Match No. 1307; SSA Computer... Human Services (HHS). ACTION: Notice of Computer Matching Program (CMP). SUMMARY: In accordance with the....Wesolowski@cms.hhs.gov . SUPPLEMENTARY INFORMATION: The Computer Matching and Privacy Protection Act of 1988...

  7. 48 CFR 234.004 - Acquisition strategy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition strategy. 234..., DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION 234.004 Acquisition strategy. (1) See 209.570 for policy applicable to acquisition strategies that consider the use of lead...

  8. 48 CFR 34.004 - Acquisition strategy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition strategy. 34... CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION General 34.004 Acquisition strategy. The program manager, as specified in agency procedures, shall develop an acquisition strategy tailored to the...

  9. Acquisition and expression of Conditioned Taste Aversion differentially affects Extracellular signal Regulated Kinase and Glutamate receptor phosphorylation in rat Prefrontal Cortex and Nucleus Accumbens

    Directory of Open Access Journals (Sweden)

    Roberto eMarotta

    2014-05-01

    Full Text Available Conditioned taste aversion (CTA can be applied to study associative learning and its relevant underpinning molecular mechanisms in discrete brain regions. The present study examined, by immunohistochemistry and immunocytochemistry, the effects of acquisition and expression of lithium-induced CTA on activated Extracellular signal Regulated Kinase (p-ERK in the prefrontal cortex (PFCx and nucleus accumbens (Acb of male Sprague-Dawley rats. The study also examined, by immunoblotting, whether acquisition and expression of lithium-induced CTA resulted in modified levels of phosphorylation of glutamate receptor subunits (NR1 and GluR1 and Thr34- and Thr75-Dopamine-and-cAMP-Regulated PhosphoProtein (DARPP-32. CTA acquisition was associated with an increase of p-ERK-positive neurons and phosphorylated NR1 receptor subunit (p-NR1 in the PFCx, whereas p-GluR1, p-Thr34- and p-Thr75-DARPP-32 levels were not changed in this brain region. CTA expression increased the number of p-ERK-positive neurons in the shell (AcbSh and core (AcbC but left unmodified p-NR1, p-GluR1, p-Thr34- and p-Thr75-DARPP-32 levels. Furthermore, post-embedding immunogold quantitative analysis in AcbSh revealed that CTA expression significantly increased nuclear p-ERK immunostaining as well as p-ERK-labeled axo-spinous contacts. Overall, these results indicate that ERK and NR1, but not GluR1 and DARPP-32, are differentially phosphorylated as a consequence of acquisition and expression of aversive associative learning. Moreover, these results confirm that CTA represents an useful approach to study the molecular basis of associative learning in rats and suggest the involvement of ERK cascade in learning-associated synaptic plasticity.

  10. 48 CFR 208.7003-2 - Assignments under coordinated acquisition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Assignments under coordinated acquisition. 208.7003-2 Section 208.7003-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES...

  11. A new model involving ethylene, nitric oxide and Fe to explain the regulation of Fe-acquisition genes in Strategy I plants.

    Science.gov (United States)

    García, María J; Suárez, Vicente; Romera, Francisco J; Alcántara, Esteban; Pérez-Vicente, Rafael

    2011-05-01

    In previous work it has been shown that both ethylene and NO (nitric oxide) participate in a similar way in the up-regulation of several Fe-acquisition genes of Arabidopsis and other Strategy I plants. This raises the question as to whether NO acts through ethylene or ethylene acts through NO, or whether both act in conjunction. One possibility is that NO could increase ethylene production. Conversely, ethylene could increase NO production. By using Arabidopsis and cucumber plants, we have found that both possibilities occur: NO greatly induces the expression in roots of genes involved in ethylene synthesis: AtSAM1, AtSAM2, AtACS4, AtACS6, AtACO1, AtACO2, AtMTK; CsACS2 and CsACO2; on the other hand, ethylene greatly enhances NO production in the subapical region of the roots. These results suggest that each substance influences the production of the other and that both substances could be necessary for up-regulation of Fe-acquisition genes. This has been further confirmed in experiments with simultaneous application of the NO donor GSNO (S-nitrosoglutathione) and ethylene inhibitors; or with simultaneous application of the ethylene precursor ACC (1-aminocyclopropane-1-carboxylic acid) and an NO scavenger. Both GSNO and ACC enhanced ferric reductase activity in control plants, but not in those plants simultaneously treated with the ethylene inhibitors or the NO scavenger, respectively. To explain all these results and previous ones we have proposed a new model involving ethylene, NO, and Fe in the up-regulation of Fe-acquisition genes of Strategy I plants. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  12. Plant phosphorus acquisition in a common mycorrhizal network: regulation of phosphate transporter genes of the Pht1 family in sorghum and flax.

    Science.gov (United States)

    Walder, Florian; Brulé, Daphnée; Koegel, Sally; Wiemken, Andres; Boller, Thomas; Courty, Pierre-Emmanuel

    2015-03-01

    In a preceding microcosm study, we found huge differences in phosphorus (P) acquisition in sorghum (Sorghum bicolor) and flax (Linum usitatissimum) sharing a common mycorrhizal network (CMN). Is the transcriptional regulation of arbuscular mycorrhizal (AM)-induced inorganic orthophosphate (Pi) transporters responsible for these differences? We characterized and analyzed the expression of Pi transporters of the Pht1 family in both plant species, and identified two new AM-inducible Pi transporters in flax. Mycorrhizal Pi acquisition was strongly affected by the combination of plant and AM fungal species. A corresponding change in the expression of two AM-inducible Pht1 transporters was noticed in both plants (SbPT9, SbPT10, LuPT5 and LuPT8), but the effect was very weak. Overall, the expression level of these genes did not explain why flax took up more Pi from the CMN than did sorghum. The post-transcriptional regulation of the transporters and their biochemical properties may be more important for their function than the fine-tuning of their gene expression.

  13. 7 CFR 989.59 - Regulation of the handling of raisins subsequent to their acquisition by handlers.

    Science.gov (United States)

    2010-01-01

    ... Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables... rules and regulations of city, county, State, Federal, or other agencies having jurisdiction....

  14. Regulation of the Type I-F CRISPR-Cas system by CRP-cAMP and GalM controls spacer acquisition and interference.

    Science.gov (United States)

    Patterson, Adrian G; Chang, James T; Taylor, Corinda; Fineran, Peter C

    2015-07-13

    The CRISPR-Cas prokaryotic 'adaptive immune systems' represent a sophisticated defence strategy providing bacteria and archaea with protection from invading genetic elements, such as bacteriophages or plasmids. Despite intensive research into their mechanism and application, how CRISPR-Cas systems are regulated is less clear, and nothing is known about the regulation of Type I-F systems. We used Pectobacterium atrosepticum, a Gram-negative phytopathogen, to study CRISPR-Cas regulation, since it contains a single Type I-F system. The CRP-cAMP complex activated the cas operon, increasing the expression of the adaptation genes cas1 and cas2-3 in addition to the genes encoding the Csy surveillance complex. Mutation of crp or cyaA (encoding adenylate cyclase) resulted in reductions in both primed spacer acquisition and interference. Furthermore, we identified a galactose mutarotase, GalM, which reduced cas operon expression in a CRP- and CyaA-dependent manner. We propose that the Type I-F system senses metabolic changes, such as sugar availability, and regulates cas genes to initiate an appropriate defence response. Indeed, elevated glucose levels reduced cas expression in a CRP- and CyaA-dependent manner. Taken together, these findings highlight that a metabolite-sensing regulatory pathway controls expression of the Type I-F CRISPR-Cas system to modulate levels of adaptation and interference.

  15. 48 CFR 908.7101-3 - Direct acquisition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Direct acquisition. 908.7101-3 Section 908.7101-3 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition of Special Items 908.7101-3...

  16. 48 CFR 1825.1101 - Acquisition of supplies.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Acquisition of supplies. 1825.1101 Section 1825.1101 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Solicitation Provisions and Contract Clauses 1825.1101 Acquisition of supplies. (c)(1) NASA...

  17. Acquisition in USTRANSCOM: An Organizational Assessment

    Science.gov (United States)

    2009-12-01

    CRAF Civil Reserve Air Fleet DAPA Defense Acquisition Performance Assessment DAR Defense Acquisition Regulation DAS Defense Acquisition...ENVIRONMENT The current Defense Acquisition Environment consists of a triad between Congress, the Executive Branch, and Industry. The DoD Program...Manager (PM) fits directly in the middle of this triad and is constantly receiving and delivering information to the entities mentioned above

  18. 48 CFR 7.402 - Acquisition methods.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition methods. 7.402... ACQUISITION PLANNING Equipment Lease or Purchase 7.402 Acquisition methods. (a) Purchase method. (1) Generally, the purchase method is appropriate if the equipment will be used beyond the point in time...

  19. Ethylene and nitric oxide involvement in the up-regulation of key genes related to iron acquisition and homeostasis in Arabidopsis.

    Science.gov (United States)

    García, María J; Lucena, Carlos; Romera, Francisco J; Alcántara, Esteban; Pérez-Vicente, Rafael

    2010-09-01

    In a previous work it was shown that ethylene participates in the up-regulation of several Fe acquisition genes of Arabidopsis, such as AtFIT, AtFRO2, and AtIRT1. In this work the relationship between ethylene and Fe-related genes in Arabidopsis has been looked at in more depth. Genes induced by Fe deficiency regulated by ethylene were searched for. For this, studies were conducted, using microarray analysis and reverse transcription-PCR (RT-PCR), to determine which of the genes up-regulated by Fe deficiency are simultaneously suppressed by two different ethylene inhibitors (cobalt and silver thiosulphate), assessing their regulation by ethylene in additional experiments. In a complementary experiment, it was determined that the Fe-related genes up-regulated by ethylene were also responsive to nitric oxide (NO). Further studies were performed to analyse whether Fe deficiency up-regulates the expression of genes involved in ethylene biosynthesis [S-adenosylmethionine synthetase, 1-aminocyclopropane-1-carboxylate (ACC) synthase, and ACC oxidase genes] and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3). The results obtained show that both ethylene and NO are involved in the up-regulation of many important Fe-regulated genes of Arabidopsis, such as AtFIT, AtbHLH38, AtbHLH39, AtFRO2, AtIRT1, AtNAS1, AtNAS2, AtFRD3, AtMYB72, and others. In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.

  20. Energy acquisition in Brazilian captive market: incentives and risks of regulation; Aquisicao de energia no mercado cativo brasileiro: incentivos e riscos da regulacao

    Energy Technology Data Exchange (ETDEWEB)

    Barros, Monica; Mello, Marina Figueira de; Souza, Reinaldo Castro [Pontificia Universidade Catolica (PUC-Rio), Rio de Janeiro, RJ (Brazil). Inst. de Energia

    2008-07-01

    The new regulatory framework in Brazilian electricity sector implemented several changes in the way energy is traded. Energy required by all captive consumers is now centrally purchased by the regulator. Distributors are only responsible for demand estimation in their concession areas. In case estimations prove wrong, distributors are punished differently for under or overestimations. Underestimations are punished harder. In this paper we simulate energy purchasing costs for a hypothetical utility in which random percentages of the forecasted demand are used. We also develop a resampling scheme for the PLD (settlement price), which is used to calculate penalties incurred by utilities. We conclude that, despite a very sophisticated regulatory framework, the system is fragile because changes in the inputs of the NEWAVE software (used to calculate the marginal cost of operations, which directly affects the PLD) yield very different punishment fees for a given (fixed) acquisition strategy.

  1. Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity

    Directory of Open Access Journals (Sweden)

    Croxatto Horacio B

    2011-01-01

    Full Text Available Abstract Background The endometrium is a dynamic tissue whose changes are driven by the ovarian steroidal hormones. Its main function is to provide an adequate substrate for embryo implantation. Using microarray technology, several reports have provided the gene expression patterns of human endometrial tissue during the window of implantation. However it is required that biological connections be made across these genomic datasets to take full advantage of them. The objective of this work was to perform a research synthesis of available gene expression profiles related to acquisition of endometrial receptivity for embryo implantation, in order to gain insights into its molecular basis and regulation. Methods Gene expression datasets were intersected to determine a consensus endometrial receptivity transcript list (CERTL. For this cluster of genes we determined their functional annotations using available web-based databases. In addition, promoter sequences were analyzed to identify putative transcription factor binding sites using bioinformatics tools and determined over-represented features. Results We found 40 up- and 21 down-regulated transcripts in the CERTL. Those more consistently increased were C4BPA, SPP1, APOD, CD55, CFD, CLDN4, DKK1, ID4, IL15 and MAP3K5 whereas the more consistently decreased were OLFM1, CCNB1, CRABP2, EDN3, FGFR1, MSX1 and MSX2. Functional annotation of CERTL showed it was enriched with transcripts related to the immune response, complement activation and cell cycle regulation. Promoter sequence analysis of genes revealed that DNA binding sites for E47, E2F1 and SREBP1 transcription factors were the most consistently over-represented and in both up- and down-regulated genes during the window of implantation. Conclusions Our research synthesis allowed organizing and mining high throughput data to explore endometrial receptivity and focus future research efforts on specific genes and pathways. The discovery of possible

  2. Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity

    Science.gov (United States)

    2011-01-01

    Background The endometrium is a dynamic tissue whose changes are driven by the ovarian steroidal hormones. Its main function is to provide an adequate substrate for embryo implantation. Using microarray technology, several reports have provided the gene expression patterns of human endometrial tissue during the window of implantation. However it is required that biological connections be made across these genomic datasets to take full advantage of them. The objective of this work was to perform a research synthesis of available gene expression profiles related to acquisition of endometrial receptivity for embryo implantation, in order to gain insights into its molecular basis and regulation. Methods Gene expression datasets were intersected to determine a consensus endometrial receptivity transcript list (CERTL). For this cluster of genes we determined their functional annotations using available web-based databases. In addition, promoter sequences were analyzed to identify putative transcription factor binding sites using bioinformatics tools and determined over-represented features. Results We found 40 up- and 21 down-regulated transcripts in the CERTL. Those more consistently increased were C4BPA, SPP1, APOD, CD55, CFD, CLDN4, DKK1, ID4, IL15 and MAP3K5 whereas the more consistently decreased were OLFM1, CCNB1, CRABP2, EDN3, FGFR1, MSX1 and MSX2. Functional annotation of CERTL showed it was enriched with transcripts related to the immune response, complement activation and cell cycle regulation. Promoter sequence analysis of genes revealed that DNA binding sites for E47, E2F1 and SREBP1 transcription factors were the most consistently over-represented and in both up- and down-regulated genes during the window of implantation. Conclusions Our research synthesis allowed organizing and mining high throughput data to explore endometrial receptivity and focus future research efforts on specific genes and pathways. The discovery of possible new transcription factors

  3. 75 FR 34283 - Federal Acquisition Regulation; FAR Case 2009-025, Disclosure and Consistency of Cost Accounting...

    Science.gov (United States)

    2010-06-16

    ... Accounting Practices for Contracts Awarded to Foreign Concerns AGENCIES: Department of Defense (DoD), General... Regulation (FAR) to align the FAR with the revised Cost Accounting Standards (CAS) Board clause, Disclosure and Consistency of Cost Accounting Practices-Foreign Concerns. DATES: Effective Date: June 16,...

  4. 78 FR 18344 - Federal Acquisition Regulation; Submission for OMB Review; Buy American Act-Free Trade Agreements...

    Science.gov (United States)

    2013-03-26

    ... Regulation; Submission for OMB Review; Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate... previously approved information collection requirement concerning the Buy American Act--Free Trade Agreements... comments identified by Information Collection 9000- 0130, Buy American Act--Free Trade Agreements--Israeli...

  5. 77 FR 52696 - Federal Acquisition Regulation; Information Collection; Drug-Free Workplace (FAR 52.223-6)

    Science.gov (United States)

    2012-08-30

    ... Regulation; Information Collection; Drug-Free Workplace (FAR 52.223-6) AGENCY: Department of Defense (DOD... approved information collection requirement concerning drug- free workplace. Public comments are... Information Collection 9000- 0101, Drug-Free Workplace, by any of the following methods:...

  6. The Influence of Self-Regulated Learning and Prior Knowledge on Knowledge Acquisition in Computer-Based Learning Environments

    Science.gov (United States)

    Bernacki, Matthew

    2010-01-01

    This study examined how learners construct textbase and situation model knowledge in hypertext computer-based learning environments (CBLEs) and documented the influence of specific self-regulated learning (SRL) tactics, prior knowledge, and characteristics of the learner on posttest knowledge scores from exposure to a hypertext. A sample of 160…

  7. 75 FR 13414 - Federal Acquisition Regulation; FAR Case 2008-012, Clarification of Submission of Cost or Pricing...

    Science.gov (United States)

    2010-03-19

    ... Regulation; FAR Case 2008-012, Clarification of Submission of Cost or Pricing Data on Non-Commercial... 814 required the harmonization of the thresholds for cost or pricing data. Specifically, section 814 required alignment of the threshold for cost or pricing data on non-commercial modifications of...

  8. 48 CFR 970.2301 - Sustainable acquisition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Sustainable acquisition. 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY..., Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable...

  9. 75 FR 391 - Medical Device Quality System Regulation Educational Forum on Risk Management Through the Product...

    Science.gov (United States)

    2010-01-05

    ... Through the Product Life Cycle; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice... System Regulation Educational Forum on Risk Management through the Product Life Cycle.'' This public...

  10. 75 FR 14448 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2010-03-25

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practices; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice of public workshop. SUMMARY: The Food and Drug Administration (FDA) Los...

  11. 78 FR 39730 - Privacy Act of 1974; CMS Computer Match No. 2013-11; HHS Computer Match No. 1302

    Science.gov (United States)

    2013-07-02

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013-11; HHS Computer Match No. 1302 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of... establishment of a CMP that CMS intends to conduct with State-based Administering Entities (AEs). Under this...

  12. 78 FR 50419 - Privacy Act of 1974; CMS Computer Match No. 2013-10; HHS Computer Match No. 1310

    Science.gov (United States)

    2013-08-19

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013-10; HHS Computer Match No. 1310 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of... establishment of a CMP that CMS plans to conduct with the Department of Homeland Security (DHS), United...

  13. 78 FR 49524 - Privacy Act of 1974; CMS Computer Match No. 2013-08; HHS Computer Match No. 1309

    Science.gov (United States)

    2013-08-14

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013-08; HHS Computer Match No. 1309 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of... establishment of a CMP that CMS plans to conduct with the Internal Revenue Service (IRS), a Bureau of...

  14. 78 FR 49525 - Privacy Act of 1974; CMS Computer Match No. 2013-06; HHS Computer Match No. 1308

    Science.gov (United States)

    2013-08-14

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013-06; HHS Computer Match No. 1308 AGENCY: Centers for Medicare & Medicaid Services (CMS), Department of... establishment of a CMP that CMS plans to conduct with the Veterans Health Administration (VHA),...

  15. 78 FR 73195 - Privacy Act of 1974: CMS Computer Matching Program Match No. 2013-01; HHS Computer Matching...

    Science.gov (United States)

    2013-12-05

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974: CMS Computer Matching... & Medicaid Services (CMS), Department of Health and Human Services (HHS). ACTION: Notice of Computer Matching... amended, this notice announces the renewal of a CMP that CMS plans to conduct with the Purchased Care...

  16. Application of wide selected-ion monitoring data-independent acquisition to identify tomato fruit proteins regulated by the CUTIN DEFICIENT2 transcription factor.

    Science.gov (United States)

    Martin, Laetitia B B; Sherwood, Robert W; Nicklay, Joshua J; Yang, Yong; Muratore-Schroeder, Tara L; Anderson, Elizabeth T; Thannhauser, Theodore W; Rose, Jocelyn K C; Zhang, Sheng

    2016-08-01

    We describe here the use of label-free wide selected-ion monitoring data-independent acquisition (WiSIM-DIA) to identify proteins that are involved in the formation of tomato (Solanum lycopersicum) fruit cuticles and that are regulated by the transcription factor CUTIN DEFICIENT2 (CD2). A spectral library consisting of 11 753 unique peptides, corresponding to 2338 tomato protein groups, was used and the DIA analysis was performed at the MS1 level utilizing narrow mass windows for extraction with Skyline 2.6 software. We identified a total of 1140 proteins, 67 of which had expression levels that differed significantly between the cd2 tomato mutant and the wild-type cultivar M82. Differentially expressed proteins including a key protein involved in cutin biosynthesis, were selected for validation by target SRM/MRM and by Western blot analysis. In addition to confirming a role for CD2 in regulating cuticle formation, the results also revealed that CD2 influences pathways associated with cell wall biology, anthocyanin biosynthesis, plant development, and responses to stress, which complements findings of earlier RNA-Seq experiments. Our results provide new insights into molecular processes and aspects of fruit biology associated with CD2 function, and demonstrate that the WiSIM-DIA is an effective quantitative approach for global protein identifications.

  17. Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor.

    Science.gov (United States)

    Guerrieri, Elena; Mallareddy, Jayapal Reddy; Tóth, Géza; Schmidhammer, Helmut; Spetea, Mariana

    2015-03-18

    Herein we report the radiolabeling and pharmacological investigation of a novel radioligand, the N-cyclobutylmethyl substituted diphenethylamine [(3)H]HS665, designed to bind selectively to the kappa opioid peptide (KOP) receptor, a target of therapeutic interest for the treatment of a variety of human disorders (i.e., pain, affective disorders, drug addiction, and psychotic disorders). HS665 was prepared in tritium-labeled form by a dehalotritiated method resulting in a specific activity of 30.65 Ci/mmol. Radioligand binding studies were performed to establish binding properties of [(3)H]HS665 to the recombinant human KOP receptor in membranes from Chinese hamster ovary cells stably expressing human KOP receptors (CHOhKOP) and to the native neuronal KOP receptor in guinea pig brain membranes. Binding of [(3)H]HS665 was specific and saturable in both tissue preparations. A single population of high affinity binding sites was labeled by [(3)H]HS665 in membranes from CHOhKOP cells and guinea pig brain with similar equilibrium dissociation constants, Kd, 0.45 and 0.64 nM, respectively. Average receptor density of [(3)H]HS665 recognition sites were 5564 and 154 fmol/mg protein in CHOhKOP cells and guinea pig brain, respectively. This study shows that the new radioligand distinguishes and labels KOP receptors specifically in neuronal and cellular systems expressing KOP receptors, making this molecule a valuable tool in probing structural and functional mechanisms governing ligand-KOP receptor interactions in both a recombinant and native in vitro setting.

  18. Mechanisms in decorin regulation of vascular endothelial growth factor-induced human trophoblast migration and acquisition of endothelial phenotype.

    Science.gov (United States)

    Lala, Neena; Girish, Gannareddy V; Cloutier-Bosworth, Alia; Lala, Peeyush K

    2012-09-01

    Extravillous trophoblast (EVT) cells of the human placenta invade the uterine decidua and utero-placental arteries to establish an efficient exchange of key molecules between maternal and fetal blood. Trophoblast invasion is stringently regulated in situ both positively and negatively by a variety of factors at the fetal-maternal interface to maintain a healthy utero-placental homeostasis. One such factor, decorin, a transforming growth factor (TGF)-beta binding, leucine-rich proteoglycan produced by the decidua, negatively regulates EVT proliferation, migration, and invasiveness independent of TGF-beta. We reported that these decorin actions were mediated by its binding to multiple tyrosine kinase receptors, including vascular endothelial growth factor receptor (VEGFR)-2. The present study explores the mechanisms underlying decorin antagonism of VEGF (VEGF-A) stimulation of endovascular differentiation of EVT using our EVT cell line, HTR-8/SVneo. We observe that decorin inhibits VEGF-induced EVT cell migration and endothelial-like tube formation on matrigel. VEGF activates MAPKs (p38 MAPK, MEK3/6, and ERK1/2) in EVT cells, and the activation is blocked in both cases by decorin. Employing selective MAPK inhibitors, we show that both p38 and ERK pathways contribute independently to VEGF-induced EVT migration and capillary-like tube formation. VEGF upregulates the vascular endothelial (VE) markers VE-cadherin and beta-catenin in EVT and endothelial cells, and this upregulation is blocked by decorin and MAPK inhibitors. These results suggest that decorin inhibits VEGF-A stimulation of trophoblast migration and endovascular differentiation by interfering with p38 MAPK and ERK1/2 activation. Thus decorin-mediated dual impediment of endovascular differentiation of the EVT and angiogenesis may have implications for pathogenesis of preeclampsia, a hypoinvasive trophoblast disorder in pregnancy.

  19. Pasteurella pneumotropica Evades the Human Complement System by Acquisition of the Complement Regulators Factor H and C4BP

    Science.gov (United States)

    Sahagún-Ruiz, Alfredo; Granados Martinez, Adriana Patricia; Breda, Leandro Carvalho Dantas; Fraga, Tatiana Rodrigues; Castiblanco Valencia, Mónica Marcela; Barbosa, Angela Silva; Isaac, Lourdes

    2014-01-01

    Pasteurella pneumotropica is an opportunist Gram negative bacterium responsible for rodent pasteurellosis that affects upper respiratory, reproductive and digestive tracts of mammals. In animal care facilities the presence of P. pneumotropica causes severe to lethal infection in immunodeficient mice, being also a potential source for human contamination. Indeed, occupational exposure is one of the main causes of human infection by P. pneumotropica. The clinical presentation of the disease includes subcutaneous abscesses, respiratory tract colonization and systemic infections. Given the ability of P. pneumotropica to fully disseminate in the organism, it is quite relevant to study the role of the complement system to control the infection as well as the possible evasion mechanisms involved in bacterial survival. Here, we show for the first time that P. pneumotropica is able to survive the bactericidal activity of the human complement system. We observed that host regulatory complement C4BP and Factor H bind to the surface of P. pneumotropica, controlling the activation pathways regulating the formation and maintenance of C3-convertases. These results show that P. pneumotropica has evolved mechanisms to evade the human complement system that may increase the efficiency by which this pathogen is able to gain access to and colonize inner tissues where it may cause severe infections. PMID:25347183

  20. 48 CFR 18.113 - Interagency acquisitions under the Economy Act.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Interagency acquisitions under the Economy Act. 18.113 Section 18.113 Federal Acquisition Regulations System FEDERAL ACQUISITION... 18.113 Interagency acquisitions under the Economy Act. Interagency acquisitions are authorized...

  1. 48 CFR 1845.7101-3 - Unit acquisition cost.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Unit acquisition cost. 1845.7101-3 Section 1845.7101-3 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACT MANAGEMENT GOVERNMENT PROPERTY Forms Preparation 1845.7101-3 Unit acquisition cost....

  2. Hyponatremic hypertensive syndrome (HHS in an 18-month old-child presenting as malignant hypertension: a case report

    Directory of Open Access Journals (Sweden)

    Theodorou Andreas

    2004-04-01

    Full Text Available Abstract Background The combination of hyponatremia and renovascular hypertension is called hyponatremic hypertensive syndrome (HHS. Malignant hypertension as a presentation has been reported in adults with HHS but is rare in children. Case presentation An eighteen month-old male presented with drowsiness, sudden onset status epilepticus and blood pressure of 210/160. The electrolytes on admission revealed sodium of 120 mEq/L and potassium of 2.1 mEq/L. The peripheral renin activity (PRA was 172 ng/ml/min (normal 3–11 ng/ml/min and serum aldosterone level was 91 ng/dl (normal 4 to 16 ng/dl. Patient underwent angioplasty with no success, followed by surgical correction. Two years since the diagnosis, the blood pressure is controlled with labetolol and amlodipine (at less than sixth of the pre-operative dosages. The PRA is 2.4 ng/ml/min and aldosterone 15.5 ng/dl. The child not only had three renal arteries on left but all of them were stenosed which to best of our knowledge has not been described. Conclusion As uncommon as HHS with malignant hypertension may be in adults it is under-reported in children and purpose of the case report is to raise its awareness.

  3. Oxytocin Signaling in Basolateral and Central Amygdala Nuclei Differentially Regulates the Acquisition, Expression, and Extinction of Context-Conditioned Fear in Rats

    Science.gov (United States)

    Campbell-Smith, Emma J.; Holmes, Nathan M.; Lingawi, Nura W.; Panayi, Marios C.; Westbrook, R. Frederick

    2015-01-01

    The present study investigated how oxytocin (OT) signaling in the central (CeA) and basolateral (BLA) amygdala affects acquisition, expression, and extinction of context-conditioned fear (freezing) in rats. In the first set of experiments, acquisition of fear to a shocked context was impaired by a preconditioning infusion of synthetic OT into the…

  4. Oxytocin Signaling in Basolateral and Central Amygdala Nuclei Differentially Regulates the Acquisition, Expression, and Extinction of Context-Conditioned Fear in Rats

    Science.gov (United States)

    Campbell-Smith, Emma J.; Holmes, Nathan M.; Lingawi, Nura W.; Panayi, Marios C.; Westbrook, R. Frederick

    2015-01-01

    The present study investigated how oxytocin (OT) signaling in the central (CeA) and basolateral (BLA) amygdala affects acquisition, expression, and extinction of context-conditioned fear (freezing) in rats. In the first set of experiments, acquisition of fear to a shocked context was impaired by a preconditioning infusion of synthetic OT into the…

  5. Mergers + acquisitions.

    Science.gov (United States)

    Hoppszallern, Suzanna

    2002-05-01

    The hospital sector in 2001 led the health care field in mergers and acquisitions. Most deals involved a network augmenting its presence within a specific region or in a market adjacent to its primary service area. Analysts expect M&A activity to increase in 2002.

  6. 48 CFR 301.606-71 - Project Officer training.

    Science.gov (United States)

    2010-10-01

    ... HHS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 301... training requirement for Project Officers and guidance on the training requirement for technical proposal...

  7. 48 CFR 301.607-75 - Maintenance of FAC-P/PM certification.

    Science.gov (United States)

    2010-10-01

    ... GENERAL HHS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities... Managers—Guidance on Meeting Requirements for Continuous Learning Points, in the P/PM Handbook for...

  8. Mergers & Acquisitions

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    and functioning of provisions of European federal corporate law and internationally accepted principles of the law of obligations. This book, however, is not about clarification of the reasons that urge for M&A operations, nor is it about judging the outcome of the transactions. It is about synthesizing......MERGERS & ACQUISITIONS: Counseling and Choice of Method describes and analyzes the current state of law in Europe in regard to some relevant selected elements related to mergers and acquisitions, and the adviser’s counsel in this regard. The focus is aimed and maintained at application......, on the one hand, the methods of M&A and, on the other hand, several selected key elements. Any participating party - as well as their respective advisers - must be aware of these elements prior, throughout, and after the transaction: consideration, succession, taxes and fiscal neutrality, group...

  9. Federal Research Opportunities: DOE, DOD, and HHS Need Better Guidance for Participant Activities

    Science.gov (United States)

    2016-01-01

    for Acquisition , Technology, and Logistics, and components within the Army, Air Force, and Navy. Page 6 GAO-16-128 Federal Research...Federal Research Opportunities An ORAU official who maintains data on appointments attributed the growth in the number of appointments to an increase in...19Due to a merger of offices, the military’s Joint Prisoner of War/Missing in Action Accounting Command is now the Defense

  10. 48 CFR 252.225-7019 - Restriction on acquisition of anchor and mooring chain.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on acquisition of anchor and mooring chain. 252.225-7019 Section 252.225-7019 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION...

  11. Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA.

    Science.gov (United States)

    Schertzer, Michael; Jouravleva, Karina; Perderiset, Mylene; Dingli, Florent; Loew, Damarys; Le Guen, Tangui; Bardoni, Barbara; de Villartay, Jean-Pierre; Revy, Patrick; Londoño-Vallejo, Arturo

    2015-02-18

    Hoyeraal-Hreidarsson syndrome (HHS) is a severe form of Dyskeratosis congenita characterized by developmental defects, bone marrow failure and immunodeficiency and has been associated with telomere dysfunction. Recently, mutations in Regulator of Telomere ELongation helicase 1 (RTEL1), a helicase first identified in Mus musculus as being responsible for the maintenance of long telomeres, have been identified in several HHS patients. Here we show that RTEL1 is required for the export and the correct cytoplasmic trafficking of the small nuclear (sn) RNA pre-U2, a component of the major spliceosome complex. RTEL1-HHS cells show abnormal subcellular partitioning of pre-U2, defects in the recycling of ribonucleotide proteins (RNP) in the cytoplasm and splicing defects. While most of these phenotypes can be suppressed by re-expressing the wild-type protein in RTEL1-HHS cells, expression of RTEL1 mutated variants in immortalized cells provokes cytoplasmic mislocalizations of pre-U2 and other RNP components, as well as splicing defects, thus phenocopying RTEL1-HHS cellular defects. Strikingly, expression of a cytoplasmic form of RTEL1 is sufficient to correct RNP mislocalizations both in RTEL1-HHS cells and in cells expressing nuclear mutated forms of RTEL1. This work unravels completely unanticipated roles for RTEL1 in RNP trafficking and strongly suggests that defects in RNP biogenesis pathways contribute to the pathology of HHS. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  12. Mergers & Acquisitions

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    This dissertation is a legal dogmatic thesis, the goal of which is to describe and analyze the current state of law in Europe in regard to some relevant selected elements related to mergers and acquisitions, and the adviser’s counsel in this regard. Having regard to the topic of the dissertation...... the focus is aimed and maintained at application and functioning of provisions of European federal corporate law and internationally accepted principles of the law of obligations. This study, however, is not about clarification of the reasons that urge for M&A operations, nor is it about judging the results...... of the transactions. This study is about synthesizing, on the one hand, the methods of M&A, and, on the other hand, several selected key elements, which any participating party, as well as their respective advisers, must be aware of, prior, throughout, and after the transaction: consideration, succession, taxes...

  13. 32 CFR 21.605 - Acquisition.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Acquisition. 21.605 Section 21.605 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Definitions § 21.605 Acquisition. The acquiring (by purchase,...

  14. 75 FR 30839 - Privacy Act of 1974; CMS Computer Match No. 2010-03, HHS Computer Match No. 1003, SSA Computer...

    Science.gov (United States)

    2010-06-02

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2010-03, HHS Computer Match No. 1003, SSA Computer Match No. 1048, IRS Project No. 241 AGENCY: Department... renewal of an existing computer matching program (CMP) that has an expiration date of June 30, 2010...

  15. 45 CFR Appendix B to Part 5b - Routine Uses Applicable to More Than One System of Records Maintained by HHS

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Routine Uses Applicable to More Than One System of Records Maintained by HHS B Appendix B to Part 5b Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... or the Civil Rights Commission, issue a subpoena to the Department for records in this system...

  16. 78 FR 42080 - Privacy Act of 1974; CMS Computer Match No. 2013-07; HHS Computer Match No. 1303; DoD-DMDC Match...

    Science.gov (United States)

    2013-07-15

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2013... Services (CMS), Department of Health and Human Services (HHS). ACTION: Notice of Computer Matching Program... announces the establishment of a CMP that CMS plans to conduct with the Department of Defense (DoD),...

  17. 78 FR 48169 - Privacy Act of 1974; CMS Computer Match No. 2013-02; HHS Computer Match No. 1306; DoD-DMDC Match...

    Science.gov (United States)

    2013-08-07

    ... Services Privacy Act of 1974; CMS Computer Match No. 2013-02; HHS Computer Match No. 1306; DoD-DMDC Match... Services (CMS). ACTION: Notice of Computer Matching Program (CMP). SUMMARY: In accordance with the requirements of the Privacy Act of 1974, as amended, this notice establishes a CMP that CMS plans to...

  18. 45 CFR 1.2 - Subject matter of Office of the Secretary regulations in parts 1-99.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Subject matter of Office of the Secretary... ADMINISTRATION HHS'S REGULATIONS § 1.2 Subject matter of Office of the Secretary regulations in parts 1-99. This subject matter of the regulations in Parts 1-99 of this title includes: • Civil...

  19. 2017 NAIP Acquisition Map

    Data.gov (United States)

    Farm Service Agency, Department of Agriculture — Planned States for 2017 NAIP acquisition and acquisition status layer (updated daily). Updates to the acquisition seasons may be made during the season to...

  20. 2016 NAIP Acquisition Map

    Data.gov (United States)

    Farm Service Agency, Department of Agriculture — Planned States for 2016 NAIP acquisition and acquisition status layer (updated daily). Updates to the acquisition seasons may be made during the season to...

  1. Flexible attosecond beamline for high harmonic spectroscopy and XUV/near-IR pump probe experiments requiring long acquisition times

    Energy Technology Data Exchange (ETDEWEB)

    Weber, S. J., E-mail: sebastien.weber@cea.fr; Manschwetus, B.; Billon, M.; Bougeard, M.; Breger, P.; Géléoc, M.; Gruson, V.; Lin, N.; Ruchon, T.; Salières, P.; Carré, B. [Commissariat l’Energie Atomique, Laser, Interactions and Dynamics Laboratory (LIDyL), DSM/IRAMIS, CEA-Saclay, 91191 Gif sur Yvette (France); Böttcher, M.; Huetz, A.; Picard, Y. J. [ISMO, UMR 8214, Université Paris-Sud, Batiment 350, Orsay (France)

    2015-03-15

    We describe the versatile features of the attosecond beamline recently installed at CEA-Saclay on the PLFA kHz laser. It combines a fine and very complete set of diagnostics enabling high harmonic spectroscopy (HHS) through the advanced characterization of the amplitude, phase, and polarization of the harmonic emission. It also allows a variety of photo-ionization experiments using magnetic bottle and COLTRIMS (COLd Target Recoil Ion Momentum Microscopy) electron spectrometers that may be used simultaneously, thanks to a two-foci configuration. Using both passive and active stabilization, special care was paid to the long term stability of the system to allow, using both experimental approaches, time resolved studies with attosecond precision, typically over several hours of acquisition times. As an illustration, applications to multi-orbital HHS and electron-ion coincidence time resolved spectroscopy are presented.

  2. 48 CFR 225.7703 - Acquisition of products or services other than small arms.

    Science.gov (United States)

    2010-10-01

    ... in Support of Operations in Iraq or Afghanistan 225.7703 Acquisition of products or services other... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of products or services other than small arms. 225.7703 Section 225.7703 Federal Acquisition Regulations System...

  3. 48 CFR 18.106 - Acquisitions from Federal Prison Industries, Inc. (FPI).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisitions from Federal Prison Industries, Inc. (FPI). 18.106 Section 18.106 Federal Acquisition Regulations System FEDERAL... Flexibilities 18.106 Acquisitions from Federal Prison Industries, Inc. (FPI). Purchase from FPI is not...

  4. 48 CFR 1.102-4 - Role of the acquisition team.

    Science.gov (United States)

    2010-10-01

    ... their particular area of responsibility within the System, and their respective role as a team member... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Role of the acquisition team. 1.102-4 Section 1.102-4 Federal Acquisition Regulations System FEDERAL ACQUISITION...

  5. 48 CFR 1405.404 - Release of long-range acquisition estimates.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Release of long-range acquisition estimates. 1405.404 Section 1405.404 Federal Acquisition Regulations System DEPARTMENT OF THE... Release of long-range acquisition estimates....

  6. 48 CFR 1305.404 - Release of long-range acquisition estimates.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Release of long-range acquisition estimates. 1305.404 Section 1305.404 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... long-range acquisition estimates....

  7. Syntax acquisition.

    Science.gov (United States)

    Crain, Stephen; Thornton, Rosalind

    2012-03-01

    Every normal child acquires a language in just a few years. By 3- or 4-years-old, children have effectively become adults in their abilities to produce and understand endlessly many sentences in a variety of conversational contexts. There are two alternative accounts of the course of children's language development. These different perspectives can be traced back to the nature versus nurture debate about how knowledge is acquired in any cognitive domain. One perspective dates back to Plato's dialog 'The Meno'. In this dialog, the protagonist, Socrates, demonstrates to Meno, an aristocrat in Ancient Greece, that a young slave knows more about geometry than he could have learned from experience. By extension, Plato's Problem refers to any gap between experience and knowledge. How children fill in the gap in the case of language continues to be the subject of much controversy in cognitive science. Any model of language acquisition must address three factors, inter alia: 1. The knowledge children accrue; 2. The input children receive (often called the primary linguistic data); 3. The nonlinguistic capacities of children to form and test generalizations based on the input. According to the famous linguist Noam Chomsky, the main task of linguistics is to explain how children bridge the gap-Chomsky calls it a 'chasm'-between what they come to know about language, and what they could have learned from experience, even given optimistic assumptions about their cognitive abilities. Proponents of the alternative 'nurture' approach accuse nativists like Chomsky of overestimating the complexity of what children learn, underestimating the data children have to work with, and manifesting undue pessimism about children's abilities to extract information based on the input. The modern 'nurture' approach is often referred to as the usage-based account. We discuss the usage-based account first, and then the nativist account. After that, we report and discuss the findings of several

  8. The Analysis of Regulating the Government’s Conducts During Corporate Mergers and Acquisitions%公司并购中政府行为规范问题探析

    Institute of Scientific and Technical Information of China (English)

    周昌仕; 齐晓亮; 赵兴楣

    2013-01-01

    It is not rare that government controlling conducts without standardization occur during corporate mergers and acquisi-tions, such as self-interest motivation; unclear responsibility; multi-goals and excessive controlling. It will possibly lead to the interest loss of the company and shareholders, lowing down the effects of the corporate mergers and acquisitions and interfering with the market operation. Therefore; it is necessary to regulate the government’s conducts in the aspects of government locating, government functions, relationship between government and enterprise and incentive and constraint mechanism.%  公司并购中屡有不规范的政府干预行为,如自利动机、职能不清、多元化目标和过度干预,有可能侵犯公司和股东利益、降低并购绩效甚至妨碍并购的市场化运作。规范政府行为需要在政府定位、政府职能、政企关系和激励与约束机制等方面做出进一步努力。

  9. 48 CFR 227.7103-2 - Acquisition of technical data.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of technical... Rights in Technical Data 227.7103-2 Acquisition of technical data. (a) Contracting officers shall work... personnel are responsible for identifying the Government's minimum needs for technical data. Data needs must...

  10. 48 CFR 945.570-2 - Acquisition of motor vehicles.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquisition of motor... Acquisition of motor vehicles. (a) The GSA Interagency Fleet Management System (GSA-IFMS) is the first source of supply for providing motor vehicles to contractors; however, contracting officer approval...

  11. 10 CFR 626.4 - General acquisition strategy.

    Science.gov (United States)

    2010-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.4 General acquisition strategy. (a) Criteria for commencing acquisition. To reduce the potential for negative impacts from market participation, DOE shall review the following...

  12. 48 CFR 939.7002 - Contractor acquisition of information technology.

    Science.gov (United States)

    2010-10-01

    ... information technology. 939.7002 Section 939.7002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Implementing DOE Policies and Procedures 939.7002 Contractor acquisition of information technology. (a) Management and operating...

  13. 48 CFR 53.212 - Acquisition of commercial items.

    Science.gov (United States)

    2010-10-01

    ... (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.212 Acquisition of commercial items. SF 1449 (Rev. 3/2005), Solicitation/Contract/Order for Commercial Items. SF 1449 is prescribed for use in... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Acquisition of...

  14. Multiple cellular roles of Neurospora crassa plc-1, splA2, and cpe-1 in regulation of cytosolic free calcium, carotenoid accumulation, stress responses, and acquisition of thermotolerance.

    Science.gov (United States)

    Barman, Ananya; Tamuli, Ranjan

    2015-04-01

    Phospholipase C1 (PLC1), secretory phospholipase A2 (sPLA2) and Ca(2+)/H(+) exchanger proteins regulate calcium signaling and homeostasis in eukaryotes. In this study, we investigate functions for phospholipase C1 (plc-1), sPLA2 (splA2) and a Ca(2+)/H(+) exchanger (cpe-1) in the filamentous fungus Neurospora crassa. The Δplc-1, ΔsplA2, and Δcpe-1 mutants exhibited a growth defect on medium supplemented with the divalent ionophore A23187, suggesting that these genes might play a role in regulation of cytosolic free Ca(2+) concentration ([Ca(2+)](c)) in N. crassa. The strains lacking plc-1, splA2, and cpe-1 possessed higher carotenoid content than wild type at 8°C, 22°C, and 30°C, and showed increased ultraviolet (UV)-survival under conditions that induced carotenoid accumulation. Moreover, Δplc-1, ΔsplA2, and Δcpe-1 mutants showed reduced survival rate under hydrogen peroxide-induced oxidative stress and induced thermotolerance after exposure to heat shock temperatures. Thus, this study revealed multiple cellular roles for plc-1, splA2, and cpe-1 genes in regulation of [Ca(2+)](c), carotenoid accumulation, survival under stress conditions, and acquisition of thermotolerance induced by heat shock.

  15. Acquisition Support Program Overview

    Science.gov (United States)

    2016-06-30

    Principles of Effective Acquisition © 2006 by Carnegie Mellon University page 31 Summary The SEI, through the Acquisition Support Program , works directly...2006 by Carnegie Mellon University page 1 Acquisition Support Program Overview Brian Gallagher Director, Acquisition Support Program 9 March, 2006...MAR 2006 2. REPORT TYPE 3. DATES COVERED 00-00-2006 to 00-00-2006 4. TITLE AND SUBTITLE Acquisition Support Program Overview 5a. CONTRACT

  16. Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM.

    Directory of Open Access Journals (Sweden)

    Dejuan Kong

    Full Text Available The emergence of castrate-resistant prostate cancer (CRPC contributes to the high mortality of patients diagnosed with prostate cancer (PCa, which in part could be attributed to the existence and the emergence of cancer stem cells (CSCs. Recent studies have shown that deregulated expression of microRNAs (miRNAs contributes to the initiation and progression of PCa. Among several known miRNAs, let-7 family appears to play a key role in the recurrence and progression of PCa by regulating CSCs; however, the mechanism by which let-7 family contributes to PCa aggressiveness is unclear. Enhancer of Zeste homolog 2 (EZH2, a putative target of let-7 family, was demonstrated to control stem cell function. In this study, we found loss of let-7 family with corresponding over-expression of EZH2 in human PCa tissue specimens, especially in higher Gleason grade tumors. Overexpression of let-7 by transfection of let-7 precursors decreased EZH2 expression and repressed clonogenic ability and sphere-forming capacity of PCa cells, which was consistent with inhibition of EZH2 3'UTR luciferase activity. We also found that the treatment of PCa cells with BR-DIM (formulated DIM: 3,3'-diindolylmethane by Bio Response, Boulder, CO, abbreviated as BR-DIM up-regulated let-7 and down-regulated EZH2 expression, consistent with inhibition of self-renewal and clonogenic capacity. Moreover, BR-DIM intervention in our on-going phase II clinical trial in patients prior to radical prostatectomy showed upregulation of let-7 consistent with down-regulation of EZH2 expression in PCa tissue specimens after BR-DIM intervention. These results suggest that the loss of let-7 mediated increased expression of EZH2 contributes to PCa aggressiveness, which could be attenuated by BR-DIM treatment, and thus BR-DIM is likely to have clinical impact.

  17. A Study of Approval Plans and the Government’s Ability to Contract for Them under the Federal Acquisition Regulation (FAR)

    Science.gov (United States)

    1989-12-01

    along with procedural methods for implementing approval plans under current Department of Defense regulations. NTFIS GRASA DTIC TAB0 Just Ifced1 By...with loshiba MAP 1988 Corporation or Kongsberg Vapenfabrikk.- OfferorS Representation 52.225-17027 Restriction on Contracting with Toshiba MAR 1988... Corporation or Kongsberg Vapenfabrikk 52.227-7031( P Data Requirements APR 1912 52-232-7007( P Progress Payments - Alternate I OCT 1916 52.233-100( P

  18. Speed in Acquisitions

    DEFF Research Database (Denmark)

    Meglio, Olimpia; King, David R.; Risberg, Annette

    2017-01-01

    The advantage of speed is often invoked by academics and practitioners as an essential condition during post-acquisition integration, frequently without consideration of the impact earlier decisions have on acquisition speed. In this article, we examine the role speed plays in acquisitions across...... the acquisition process using research organized around characteristics that display complexity with respect to acquisition speed. We incorporate existing research with a process perspective of acquisitions in order to present trade-offs, and consider the influence of both stakeholders and the pre......-deal-completion context on acquisition speed, as well as the organization’s capabilities to facilitating that speed. Observed trade-offs suggest both that acquisition speed often requires longer planning time before an acquisition and that associated decisions require managerial judgement. A framework for improving...

  19. 48 CFR 301.607-72 - Applicability.

    Science.gov (United States)

    2010-10-01

    ... ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 301.607-72... construction capital investment acquisitions. Consistent with OFPP guidance, HHS requires FAC-P/PM Level III...

  20. Language Acquisition without an Acquisition Device

    Science.gov (United States)

    O'Grady, William

    2012-01-01

    Most explanatory work on first and second language learning assumes the primacy of the acquisition phenomenon itself, and a good deal of work has been devoted to the search for an "acquisition device" that is specific to humans, and perhaps even to language. I will consider the possibility that this strategy is misguided and that language…

  1. Language Acquisition without an Acquisition Device

    Science.gov (United States)

    O'Grady, William

    2012-01-01

    Most explanatory work on first and second language learning assumes the primacy of the acquisition phenomenon itself, and a good deal of work has been devoted to the search for an "acquisition device" that is specific to humans, and perhaps even to language. I will consider the possibility that this strategy is misguided and that language…

  2. 76 FR 31395 - Federal Acquisition Regulation; Sustainable Acquisition

    Science.gov (United States)

    2011-05-31

    ... not using electronic commerce methods, to submit paper ] documents to the Government on double-sided... eliminate waste. Electronic commerce methods (see 4.502) and double-sided printing and copying are best practices for waste prevention. (b) When electronic commerce methods (see 4.502) are not used,...

  3. Calo trigger acquisition system

    CERN Multimedia

    Franchini, Matteo

    2016-01-01

    Calo trigger acquisition system - Evolution of the acquisition system from a multiple boards system (upper, orange cables) to a single board one (below, light blue cables) where all the channels are collected in a single board.

  4. Software Acquisition Program Dynamics

    Science.gov (United States)

    2011-10-24

    techniques to avoid these problems The Objective • Improve acquisition program staff decision-making, and thus improve acquisition program outcomes...classroom training, eLearning , certification, and more—to serve the needs of customers and partners worldwide.

  5. Modelling live forensic acquisition

    CSIR Research Space (South Africa)

    Grobler, MM

    2009-06-01

    Full Text Available This paper discusses the development of a South African model for Live Forensic Acquisition - Liforac. The Liforac model is a comprehensive model that presents a range of aspects related to Live Forensic Acquisition. The model provides forensic...

  6. Playing at Serial Acquisitions

    NARCIS (Netherlands)

    J.T.J. Smit (Han); T. Moraitis (Thras)

    2010-01-01

    textabstractBehavioral biases can result in suboptimal acquisition decisions-with the potential for errors exacerbated in consolidating industries, where consolidators design serial acquisition strategies and fight escalating takeover battles for platform companies that may determine their future co

  7. DOD Acquisition Workforce Reduction Trends and Impacts

    Science.gov (United States)

    2016-06-07

    open competition to the maximum extent practicable. Further defining the requirements associated with market research is Federal Acquisition Regulation... operational testing; logistics operations ; maintenance depots, including "USMC [U.S. Marine Corps]; and S&T [Science and Technology]." Section 931(d) of...Organization Special Operations Command Acquisition Center Subtotal Department of the Army Army Materiel Command Army Information Systems Command3

  8. Transcriptome Sequencing Identifies SPL7-Regulated Copper Acquisition Genes FRO4/FRO5 and the Copper Dependence of Iron Homeostasis in Arabidopsis[C][W

    Science.gov (United States)

    Bernal, María; Casero, David; Singh, Vasantika; Wilson, Grandon T.; Grande, Arne; Yang, Huijun; Dodani, Sheel C.; Pellegrini, Matteo; Huijser, Peter; Connolly, Erin L.; Merchant, Sabeeha S.; Krämer, Ute

    2012-01-01

    The transition metal copper (Cu) is essential for all living organisms but is toxic when present in excess. To identify Cu deficiency responses comprehensively, we conducted genome-wide sequencing-based transcript profiling of Arabidopsis thaliana wild-type plants and of a mutant defective in the gene encoding SQUAMOSA PROMOTER BINDING PROTEIN-LIKE7 (SPL7), which acts as a transcriptional regulator of Cu deficiency responses. In response to Cu deficiency, FERRIC REDUCTASE OXIDASE5 (FRO5) and FRO4 transcript levels increased strongly, in an SPL7-dependent manner. Biochemical assays and confocal imaging of a Cu-specific fluorophore showed that high-affinity root Cu uptake requires prior FRO5/FRO4-dependent Cu(II)-specific reduction to Cu(I) and SPL7 function. Plant iron (Fe) deficiency markers were activated in Cu-deficient media, in which reduced growth of the spl7 mutant was partially rescued by Fe supplementation. Cultivation in Cu-deficient media caused a defect in root-to-shoot Fe translocation, which was exacerbated in spl7 and associated with a lack of ferroxidase activity. This is consistent with a possible role for a multicopper oxidase in Arabidopsis Fe homeostasis, as previously described in yeast, humans, and green algae. These insights into root Cu uptake and the interaction between Cu and Fe homeostasis will advance plant nutrition, crop breeding, and biogeochemical research. PMID:22374396

  9. Immunogenicity of iron-regulated outer membrane proteins of Pasteurella multocida A:3 in cattle: molecular characterization of the immunodominant heme acquisition system receptor (HasR) protein.

    Science.gov (United States)

    Prado, M E; Dabo, S M; Confer, A W

    2005-02-25

    The iron-regulated outer membrane proteins (IROMPs) of Pasteurella multocida A:3 strain 232 (Pm232), a bovine isolate, were investigated as potential immunogens in cattle. We addressed the ability of P. multocida IROMP-enriched fractions to induce antibody responses in cattle by different vaccination strategies and the protective efficacy of these antibodies using a P. multocida-induced pneumonia challenge model. Vaccination of cattle with outer membrane-enriched fractions derived from Pm232 grown on either iron-depleted (IROMPs) or iron-sufficient (OMPs) conditions induced significant antibody responses; however, the correlation with lung lesion scores was not significant (P = 0.01 and P multocida (strain Pm70) and was confirmed by DNA sequence analysis of the cloned Pm232 hasR gene. Further analyses indicated that Pm232 HasR is a surface-exposed OMP and conserved among most P. multocida isolates investigated. In addition, cattle vaccinated with live Pm232 or IROMPs had significantly higher antibody responses to the 96 kDa protein band and the correlation with lung lesion scores approached significance (P = 0.056). These results indicate that antibody responses in cattle are induced by P. multocida IROMPs, and that the 96 kDa HasR protein is an immunodominant IROMP.

  10. Identification of genes that regulate phosphate acquisition and plant performance during arbuscular my corrhizal symbiosis in medicago truncatula and brachypodium distachyon

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, Maria J [Boyce Thompson Institute, Ithaca, NY (United States); Hudson, Matthew E [Univ. of Illinois, Champaign, IL (United States)

    2015-11-24

    Most vascular flowering plants have the ability to form symbiotic associations with arbuscular mycorrhizal (AM) fungi. The symbiosis develops in the roots and can have a profound effect on plant productivity, largely through improvements in plant mineral nutrition. Within the root cortical cells, the plant and fungus create novel interfaces specialized for nutrient transfer, while the fungus also develops a network of hyphae in the rhizosphere. Through this hyphal network, the fungus acquires and delivers phosphate and nitrogen to the root. In return, the plant provides the fungus with carbon. In addition, to enhancing plant mineral nutrition, the AM symbiosis has an important role in the carbon cycle, and positive effects on soil health. Here we identified and characterized plant genes involved in the regulation and functioning of the AM symbiosis in Medicago truncatula and Brachypodium distachyon. This included the identification and and characterization of a M. truncatula transcription factors that are required for symbiosis. Additionally, we investigated the molecular basis of functional diversity among AM symbioses in B. distachyon and analysed the transcriptome of Brachypodium distachyon during symbiosis.

  11. 48 CFR 2801.603-1 - Department of Justice Acquisition Career Management Program.

    Science.gov (United States)

    2010-10-01

    ... Acquisition Career Management Program. 2801.603-1 Section 2801.603-1 Federal Acquisition Regulations System..., Contracting Authority, and Responsibilities 2801.603-1 Department of Justice Acquisition Career Management Program. (a) Each Bureau Procurement Chief shall develop and manage an acquisition career management...

  12. 75 FR 51824 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2010-08-23

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice of public workshop. ] SUMMARY: The Food and Drug Administration (FDA) New Jersey...

  13. HHS Enterprise Data Inventory

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Enterprise Data Inventory (EDI) is the comprehensive inventory listing of agency data resources including public, restricted public, and non-public datasets.

  14. 48 CFR 1419.503 - Setting aside a class of acquisitions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Setting aside a class of acquisitions. 1419.503 Section 1419.503 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 1419.503 Setting aside a class...

  15. Excessive acquisition in hoarding.

    Science.gov (United States)

    Frost, Randy O; Tolin, David F; Steketee, Gail; Fitch, Kristin E; Selbo-Bruns, Alexandra

    2009-06-01

    Compulsive hoarding (the acquisition of and failure to discard large numbers of possessions) is associated with substantial health risk, impairment, and economic burden. However, little research has examined separate components of this definition, particularly excessive acquisition. The present study examined acquisition in hoarding. Participants, 878 self-identified with hoarding and 665 family informants (not matched to hoarding participants), completed an Internet survey. Among hoarding participants who met criteria for clinically significant hoarding, 61% met criteria for a diagnosis of compulsive buying and approximately 85% reported excessive acquisition. Family informants indicated that nearly 95% exhibited excessive acquisition. Those who acquired excessively had more severe hoarding; their hoarding had an earlier onset and resulted in more psychiatric work impairment days; and they experienced more symptoms of obsessive-compulsive disorder, depression, and anxiety. Two forms of excessive acquisition (buying and free things) each contributed independent variance in the prediction of hoarding severity and related symptoms.

  16. Acquisition IT Integration

    DEFF Research Database (Denmark)

    Henningsson, Stefan; Øhrgaard, Christian

    2015-01-01

    The IT integration of acquisitions consists an important challenge for the many acquiring organizations. Complementing existing research, this paper searches for explanation to differences in acquirers’ abilities for acquisition IT integration in the external of the acquirer, by a study of the use...... of temporary agency workers. Following an analytic induction approach, theoretically grounded in the re-source-based view of the firm, we identify the complimentary and supplementary roles consultants can assume in acquisition IT integration. Through case studies of three acquirers, we investigate how...... of the acquisition IT integration team should consider the balance of these, in practice, commonly mutually excluding needs....

  17. 75 FR 19827 - Acquisition Regulation Rewrite

    Science.gov (United States)

    2010-04-15

    ... suspected violations. Subpart 1403.10--Contractor Code of Business Ethics and Conduct 1403.1004 Contract... impose any new requirements on small entities. 4. Small Business Regulatory Enforcement Fairness Act (SBREFA) This rule is not a major rule under 5 U.S.C. 804(2), the Small Business Regulatory Enforcement...

  18. 77 FR 73523 - HUD Acquisition Regulations (HUDAR)

    Science.gov (United States)

    2012-12-10

    ... address the organizational structure of HUD, and adding provisions on contractor record retention. DATES...--Organizational and Consultant Conflicts of Interest 0 22. Revise section 2409.503 to read as follows: 2409.503...

  19. 75 FR 33752 - Acquisition Regulation: Socioeconomic Programs

    Science.gov (United States)

    2010-06-15

    ... have no impact on the autonomy or integrity of the family as an institution. Accordingly, DOE has.... Removing ``Small, Small Disadvantaged and Women-Owned Subcontracting Plan'' in paragraphs (c) and (d) and..., Small Disadvantaged and Women-Owned Subcontracting Plan'' in paragraph (c)(2) and adding in its...

  20. 75 FR 69009 - Acquisition Regulation: Socioeconomic Programs

    Science.gov (United States)

    2010-11-10

    ... family well-being. This rule will have no impact on the autonomy or integrity of the family as an... Women-Owned Subcontracting Plan'' in paragraphs (c) and (d) and adding in its place ``Small Business... paragraph (b)(2) after the ``;''; and 0 d. Removing ``Small, Small Disadvantaged and...

  1. 76 FR 15901 - Acquisition Regulation Miscellaneous Changes

    Science.gov (United States)

    2011-03-22

    ... identifying information--may be made publicly available at any time. While you can ask us in your comment to... 12866. (1) This rule will not have an effect of $100 million or more on the economy. The costs.... This rule will not adversely affect in a material way the economy, productivity, competition, jobs, the...

  2. Acquisition Research Program Homepage

    OpenAIRE

    2015-01-01

    Includes an image of the main page on this date and compressed file containing additional web pages. Established in 2003, Naval Postgraduate School’s (NPS) Acquisition Research Program provides leadership in innovation, creative problem solving and an ongoing dialogue, contributing to the evolution of Department of Defense acquisition strategies.

  3. Coring Sample Acquisition Tool

    Science.gov (United States)

    Haddad, Nicolas E.; Murray, Saben D.; Walkemeyer, Phillip E.; Badescu, Mircea; Sherrit, Stewart; Bao, Xiaoqi; Kriechbaum, Kristopher L.; Richardson, Megan; Klein, Kerry J.

    2012-01-01

    A sample acquisition tool (SAT) has been developed that can be used autonomously to sample drill and capture rock cores. The tool is designed to accommodate core transfer using a sample tube to the IMSAH (integrated Mars sample acquisition and handling) SHEC (sample handling, encapsulation, and containerization) without ever touching the pristine core sample in the transfer process.

  4. Robotization in Seismic Acquisition

    NARCIS (Netherlands)

    Blacquière, G.; Berkhout, A.J.

    2013-01-01

    The amount of sources and detectors in the seismic method follows "Moore’s Law of seismic data acquisition", i.e., it increases approximately by a factor of 10 every 10 years. Therefore automation is unavoidable, leading to robotization of seismic data acquisition. Recently, we introduced a new

  5. Second language acquisition

    NARCIS (Netherlands)

    Kootstra, G.J.; Dijkstra, A.F.J.; Starren, M.B.P.

    2015-01-01

    This contribution provides an overview of second language acquisition research from a psycholinguistic perspective. The overview is mainly focused on cross-language interactions during word and sentence production and comprehension at different points in the second-language acquisition process. The

  6. 76 FR 33307 - Strengthen and Promote the Role of Local Health Departments in Retail Food Safety Regulation (U-50)

    Science.gov (United States)

    2011-06-08

    ... in Retail Food Safety Regulation (U-50) AGENCY: Food and Drug Administration, HHS. ACTION: Notice... support of a cooperative agreement between the Center for Food Safety and Applied Nutrition (CFSAN) and.... Salsbury, Center for Food Safety and Applied Nutrition (HFS-320), Food and Drug Administration, 5100 Paint...

  7. Mergers and Acquisitions

    DEFF Research Database (Denmark)

    Risberg, Annette

    , employee experiences and communication. Mergers and acquisitions remain one of the most common forms of growth, yet they present considerable challenges for the companies and management involved. The effects on stakeholders, including shareholders, managers and employees, must be considered as well......Introduction to the study of mergers and acquisitions. This book provides an understanding of the mergers and acquisitions process, how and why they occur, and also the broader implications for organizations. It presents issues including motives and planning, partner selection, integration...... by editorial commentaries and reflects the important organizational and behavioural aspects which have often been ignored in the past. By providing this in-depth understanding of the mergers and acquisitions process, the reader understands not only how and why mergers and acquisitions occur, but also...

  8. 7 CFR 1610.7 - Acquisition of certain exchange facilities.

    Science.gov (United States)

    2010-01-01

    ... Section 1610.7 Agriculture Regulations of the Department of Agriculture (Continued) RURAL TELEPHONE BANK, DEPARTMENT OF AGRICULTURE LOAN POLICIES § 1610.7 Acquisition of certain exchange facilities. In the interest of making optimum use of the Bank's loan funds, a Bank loan for the acquisition of...

  9. 12 CFR 225.132 - Acquisition of assets.

    Science.gov (United States)

    2010-01-01

    ... Companies Interpretations § 225.132 Acquisition of assets. (a) From time to time questions have arisen as to... the Board's Regulation Y (12 CFR 225.4(c)(3)) generally prohibits a bank holding company or its... any merger “or acquisition of assets other than in the ordinary course of business” without...

  10. 10 CFR 626.5 - Acquisition procedures-general.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Acquisition procedures-general. 626.5 Section 626.5 Energy DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC... and commercial facilities receipt capabilities. (3) DOE shall strive to maximize U.S. flag...

  11. 48 CFR 3419.870 - Acquisition of technical requirements.

    Science.gov (United States)

    2010-10-01

    ... ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS AND SMALL DISADVANTAGED BUSINESS CONCERNS Contracting With the Small Business Administration (The 8(a) Program) 3419.870 Acquisition of technical... SBA through a limited technical competition if technical aspects, methodology, or approach are of...

  12. STIS target acquisition

    Science.gov (United States)

    Kraemer, Steve; Downes, Ron; Katsanis, Rocio; Crenshaw, Mike; McGrath, Melissa; Robinson, Rich

    1997-01-01

    We describe the STIS autonomous target acquisition capabilities. We also present the results of dedicated tests executed as part of Cycle 7 calibration, following post-launch improvements to the Space Telescope Imaging Spectrograph (STIS) flight software. The residual pointing error from the acquisitions are < 0.5 CCD pixels, which is better than preflight estimates. Execution of peakups show clear improvement of target centering for slits of width 0.1 sec or smaller. These results may be used by Guest Observers in planning target acquisitions for their STIS programs.

  13. The Problematic of Small-Scale Land Acquisition (Less than 5 Hectares for Public Interest Development

    Directory of Open Access Journals (Sweden)

    Donna Okhtalia Setiabudhi

    2016-04-01

    Full Text Available Land acquisition for public interest development is stipulated in Act No. 2 of 2012 concerning Land Acquisition for Development of Public Interest. One arrangement of land acquisition in legal substances that have been formed are small-scale land acquisition (less than 5 hectares, but it is still governed by very vague and thus susceptible to the multi-interpretation and raises doubts in its implementation. This paper discusses the problematic that arise due to unclear regulations concerning small-scale land acquisition and to provide solutions to these problems. Based on the discussion the authors concluded first, the problematic of small-scale land acquisition is the arrangement of land acquisition that is so vague that there is no clarity regarding the procedures for determining of location, the phase of land acquisition, which excludes public consultation, there is no regulation regarding preventive measures against the impact for the community around location of land acquisition. Second, the solution could be found to this problem is a regulation of small-scale land acquisition should ideally be regulated more comprehensively considering that small-scale land acquisition allows the emergence of adverse effects for the community around location of land acquisition so that the stages of planning and preparation that is set for the large-scale land acquisition is similarly applied for small-scale.

  14. Acquisition Workforce Annual Report 2006

    Data.gov (United States)

    General Services Administration — This is the Federal Acquisition Institute's (FAI's) Annual demographic report on the Federal acquisition workforce, showing trends by occupational series, employment...

  15. Acquisition Workforce Annual Report 2008

    Data.gov (United States)

    General Services Administration — This is the Federal Acquisition Institute's (FAI's) Annual demographic report on the Federal acquisition workforce, showing trends by occupational series, employment...

  16. FWS Approved Acquisition Boundaries

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the external boundaries of lands and waters that are approved for acquisition by the U.S. Fish and Wildlife Service (USFWS) in North America,...

  17. FWS Approved Acquisition Boundaries

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the external boundaries of lands and waters that are approved for acquisition by the U.S. Fish and Wildlife Service (USFWS) in North...

  18. Acquisition IT Integration

    DEFF Research Database (Denmark)

    Henningsson, Stefan; Øhrgaard, Christian

    2015-01-01

    The IT integration of acquisitions consists an important challenge for the many acquiring organizations. Complementing existing research, this paper searches for explanation to differences in acquirers’ abilities for acquisition IT integration in the external of the acquirer, by a study of the use...... of temporary agency workers. Following an analytic induction approach, theoretically grounded in the re-source-based view of the firm, we identify the complimentary and supplementary roles consultants can assume in acquisition IT integration. Through case studies of three acquirers, we investigate how...... the acquirers appropriate the use of agency workers as part of its acquisition strategy. For the investigated acquirers, assigning roles to agency workers is contingent on balancing the needs of knowledge induction and knowledge retention, as well as experience richness and in-depth under-standing. Composition...

  19. FWS Approved Acquisition Boundaries

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the external boundaries of lands and waters that are approved for acquisition by the U.S. Fish and Wildlife Service (USFWS) in North America,...

  20. USB data acquisition solution

    Institute of Scientific and Technical Information of China (English)

    Serges Lemo; Zhu June

    2007-01-01

    @@ 1 Introduction In recent years, USB has evolved from a simple, low-speed peripheral bus for mice, keyboards, and other computer accessories to the bus of choice for more demanding applications, including data acquisition (DAQ).

  1. Study of the H+HS reaction on a newly built potential energy surface using the quasi-classical trajectory method

    Institute of Scientific and Technical Information of China (English)

    Bai Meng-Meng; Ge Mei-Hua; Yang Huan; Zheng Yu-Jun

    2012-01-01

    The quasi-classical trajectory (QCT) method is used to study the H+HS reaction on a newly built potential energy surface (PES) of the triplet state of H2S (3A") in a collision energy range of 0-60 kcal/mol.Both scalar properties,such as the reaction probability and the integral cross section (ICS),and the vector properties,such as the angular distribution between the relative velocity vector of the reactant and that of the product,etc.,are investigated using the QCT method.It is found that the ICSs obtained by the QCT method and the quantum mechanical (QM) method accord well with each other.In addition,the distribution for the product vibrational states is cold,while that for the product rotational states is hot for both reaction channels in the whole energy range studied here.

  2. Study of the H+HS reaction on a newly built potential energy surface using the quasi-classical trajectory method

    Science.gov (United States)

    Bai, Meng-Meng; Ge, Mei-Hua; Yang, Huan; Zheng, Yu-Jun

    2012-12-01

    The quasi-classical trajectory (QCT) method is used to study the H+HS reaction on a newly built potential energy surface (PES) of the triplet state of H2S (3A″) in a collision energy range of 0-60 kcal/mol. Both scalar properties, such as the reaction probability and the integral cross section (ICS), and the vector properties, such as the angular distribution between the relative velocity vector of the reactant and that of the product, etc., are investigated using the QCT method. It is found that the ICSs obtained by the QCT method and the quantum mechanical (QM) method accord well with each other. In addition, the distribution for the product vibrational states is cold, while that for the product rotational states is hot for both reaction channels in the whole energy range studied here.

  3. 48 CFR 301.704 - Content.

    Science.gov (United States)

    2000-10-01

    ... 48 Federal Acquisition Regulations System 4 2000-10-01 2000-10-01 false Content. 301.704 Section 301.704 Federal Acquisition Regulations System DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Determinations and Findings 301.704 Content. An example of a D&F format may be...

  4. Glutamate dehydrogenase: structure, allosteric regulation, and role in insulin homeostasis.

    Science.gov (United States)

    Li, Ming; Li, Changhong; Allen, Aron; Stanley, Charles A; Smith, Thomas J

    2014-01-01

    Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of L-glutamate to 2-oxoglutarate. Only in the animal kingdom is this enzyme heavily allosterically regulated by a wide array of metabolites. The major activators are ADP and leucine and inhibitors include GTP, palmitoyl CoA, and ATP. Spontaneous mutations in the GTP inhibitory site that lead to the hyperinsulinism/hyperammonemia (HHS) syndrome have shed light as to why mammalian GDH is so tightly regulated. Patients with HHS exhibit hypersecretion of insulin upon consumption of protein and concomitantly extremely high levels of ammonium in the serum. The atomic structures of four new inhibitors complexed with GDH complexes have identified three different allosteric binding sites. Using a transgenic mouse model expressing the human HHS form of GDH, at least three of these compounds blocked the dysregulated form of GDH in pancreatic tissue. EGCG from green tea prevented the hyper-response to amino acids in whole animals and improved basal serum glucose levels. The atomic structure of the ECG-GDH complex and mutagenesis studies is directing structure-based drug design using these polyphenols as a base scaffold. In addition, all of these allosteric inhibitors are elucidating the atomic mechanisms of allostery in this complex enzyme.

  5. The structure and allosteric regulation of mammalian glutamate dehydrogenase.

    Science.gov (United States)

    Li, Ming; Li, Changhong; Allen, Aron; Stanley, Charles A; Smith, Thomas J

    2012-03-15

    Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of l-glutamate to 2-oxoglutarate. Only in the animal kingdom is this enzyme heavily allosterically regulated by a wide array of metabolites. The major activators are ADP and leucine, while the most important inhibitors include GTP, palmitoyl CoA, and ATP. Recently, spontaneous mutations in the GTP inhibitory site that lead to the hyperinsulinism/hyperammonemia (HHS) syndrome have shed light as to why mammalian GDH is so tightly regulated. Patients with HHS exhibit hypersecretion of insulin upon consumption of protein and concomitantly extremely high levels of ammonium in the serum. The atomic structures of four new inhibitors complexed with GDH complexes have identified three different allosteric binding sites. Using a transgenic mouse model expressing the human HHS form of GDH, at least three of these compounds were found to block the dysregulated form of GDH in pancreatic tissue. EGCG from green tea prevented the hyper-response to amino acids in whole animals and improved basal serum glucose levels. The atomic structure of the ECG-GDH complex and mutagenesis studies is directing structure-based drug design using these polyphenols as a base scaffold. In addition, all of these allosteric inhibitors are elucidating the atomic mechanisms of allostery in this complex enzyme.

  6. 75 FR 32719 - Acquisition Regulation: Agency Supplementary Regulations

    Science.gov (United States)

    2010-06-09

    ... 12988 C. Review Under the Regulatory Flexibility Act D. Review Under the Paperwork Reduction Act E... contracting officer the authority to extend the time needed for the contractor to submit the workplace... by the contractor for the submission of the workplace substance abuse program plan. This change will...

  7. 75 FR 68217 - Acquisition Regulation: Agency Supplementary Regulations

    Science.gov (United States)

    2010-11-05

    ... for compensation for personal services, it removes the reference to the personnel appendix. Paragraph...-being. This rule will have no impact on the autonomy or integrity of the family as an institution...)(1) and adding in its place ``48 CFR''. 970.3102-05-6 Compensation for personal services....

  8. 77 FR 6549 - Acquisition of Items for Which Federal Prison Industries Has a Significant Market Share

    Science.gov (United States)

    2012-02-08

    ... Defense Acquisition Regulations System Acquisition of Items for Which Federal Prison Industries Has a... notification to set forth an up-to-date list of product categories for which the Federal Prison Industries...'s competition requirements for acquisition of products from Federal Prison Industries (FPI)....

  9. 48 CFR 919.503 - Setting aside a class of acquisitions.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 919.503 Setting aside a class of acquisitions. By agreement with SBA, the DOE has established a class set-aside for construction acquisitions... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Setting aside a class...

  10. Post-Acquisition IT Integration

    DEFF Research Database (Denmark)

    Henningsson, Stefan; Yetton, Philip

    2013-01-01

    The extant research on post-acquisition IT integration analyzes how acquirers realize IT-based value in individual acquisitions. However, serial acquirers make 60% of acquisitions. These acquisitions are not isolated events, but are components in growth-by-acquisition programs. To explain how...... serial acquirers realize IT-based value, we develop three propositions on the sequential effects on post-acquisition IT integration in acquisition programs. Their combined explanation is that serial acquirers must have a growth-by-acquisition strategy that includes the capability to improve...... IT integration capabilities, to sustain high alignment across acquisitions and to maintain a scalable IT infrastructure with a flat or decreasing cost structure. We begin the process of validating the three propositions by investigating a longitudinal case study of a growth-by-acquisition program....

  11. VERITAS Data Acquisition

    Science.gov (United States)

    Hays, E.

    VERITAS employs a multi-stage data acquisition chain that extends from the VME readout of custom 500 MHz flash ADC electronics to the construction of telescope events and ultimately the compilation of information from each telescope into array level data. These systems provide access to the programming of the channel level triggers and the FADCs. They also ensure the proper synchronization of event information across the array and provide the first level of data quality monitoring. Additionally, the data acquisition includes features to handle the readout of special trigger types and to monitor channel scaler rates. In this paper we describe the software and hardware components of the systems and the protocols used to communicate between the VME, telescope, and array levels. We also discuss the performance of the data acquisition for array operations.

  12. VERITAS Data Acquisition

    CERN Document Server

    Hays, E

    2007-01-01

    VERITAS employs a multi-stage data acquisition chain that extends from the VME readout of custom 500 MS/s flash ADC electronics to the construction of telescope events and ultimately the compilation of information from each telescope into array level data. These systems provide access to the programming of the channel level triggers and the FADCs. They also ensure the proper synchronization of event information across the array and provide the first level of data quality monitoring. Additionally, the data acquisition includes features to handle the readout of special trigger types and to monitor channel scaler rates. In this paper we describe the software and hardware components of the systems and the protocols used to communicate between the VME, telescope, and array levels. We also discuss the performance of the data acquisition for array operations.

  13. Knowledge Transfers following Acquisition

    DEFF Research Database (Denmark)

    Gammelgaard, Jens

    2001-01-01

    Prior relations between the acquiring firm and the target company pave the way for knowledge transfers subsequent to the acquisitions. One major reason is that through the market-based relations the two actors build up mutual trust and simultaneously they learn how to communicate. An empirical...... study of 54 Danish acquisitions taking place abroad from 1994 to 1998 demonstrated that when there was a high level of trust between the acquiring firm and the target firm before the take-over, then medium and strong tie-binding knowledge transfer mechanisms, such as project groups and job rotation...

  14. Merger and acquisition medicine.

    Science.gov (United States)

    Powell, G S

    1997-01-01

    This discussion of the ramifications of corporate mergers and acquisitions for employees recognizes that employee adaptation to the change can be a long and complex process. The author describes a role the occupational physician can take in helping to minimize the potential adverse health impact of major organizational change.

  15. Interaction and Language Acquisition

    Institute of Scientific and Technical Information of China (English)

    孙红叶

    2016-01-01

    Based on Long's Interaction Hypothesis (IH), the paper examines the aspects of interaction that might facilitate natu-ralistic language development and goes further to propose features of interaction that could encourage classroom second lan-guage acquisition, in the hope that improved classroom interation will enhance teaching effectiveness in language classroom.

  16. Second Language Acquisition.

    Science.gov (United States)

    McLaughlin, Barry; Harrington, Michael

    1989-01-01

    A distinction is drawn between representational and processing models of second-language acquisition. The first approach is derived primarily from linguistics, the second from psychology. Both fields, it is argued, need to collaborate more fully, overcoming disciplinary narrowness in order to achieve more fruitful research. (GLR)

  17. Competencies: requirements and acquisition

    NARCIS (Netherlands)

    Kuenn, A.C.; Meng, C.M.; Peters, Z.; Verhagen, A.M.C.

    2013-01-01

    Higher education is given the key task to prepare the highly talented among the young to fulfil highly qualified roles in the labour market. Successful labour market performance of graduates is generally associated with the acquisition of the correct competencies. Education as an individual investme

  18. Acquisition of Comparison Constructions

    Science.gov (United States)

    Hohaus, Vera; Tiemann, Sonja; Beck, Sigrid

    2014-01-01

    This article presents a study on the time course of the acquisition of comparison constructions. The order in which comparison constructions (comparatives, measure phrases, superlatives, degree questions, etc.) show up in English- and German-learning children's spontaneous speech is quite fixed. It is shown to be insufficiently determined by…

  19. Surviving mergers & acquisitions.

    Science.gov (United States)

    Dixon, Diane L

    2002-01-01

    Mergers and acquisitions are never easy to implement. The health care landscape is a minefield of failed mergers and uneasy alliances generating great turmoil and pain. But some mergers have been successful, creating health systems that benefit the communities they serve. Five prominent leaders offer their advice on minimizing the difficulties of M&As.

  20. An Analysis of Army Rapid Acquisition

    Science.gov (United States)

    2015-09-01

    reporting structure  Empowerment of leaders and employees to do their jobs160  Focus on one or two products at a time  Involvement of system users in...manufacturing development EUL economic useful life EUT early user test FAR Federal Acquisition Regulation FOC full operational capability FReM... user - initiated ONS process has funding available to support needs quickly, and attempts to respond to an ONS within 14 days. Response time varies

  1. 77 FR 39125 - Defense Acquisition Regulations System; Defense Federal Acquisition Regulation Supplement; Only...

    Science.gov (United States)

    2012-06-29

    ... in which the price is determined fair and reasonable based on certified cost or pricing data from... obtaining certified cost or pricing data are met. 2. DFARS 215.371-2. A section has been added to address... DFARS 215.371(c)(2). The contracting officer is not required to obtain further cost or pricing data if...

  2. Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA); interpretation of "federal public benefit"--HHS. Notice with comment period.

    Science.gov (United States)

    1998-08-04

    This notice with comment period interprets the term "Federal public benefit" as used in Title IV of the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA), Pub. L. 104-193, and identifies the HHS programs that provide such benefits under this interpretation. According to section 401 if PRWORA, aliens who are not "qualified aliens" are not eligible for any "Federal public benefit," unless the "Federal public benefit" falls within a specified exception. A "Federal public benefit" includes "any grant, contract, loan, professional license, or commercial license" provided to an individual, and also "any retirement, welfare, health, disability, public or assisted housing, postsecondary education, food assistance, unemployment benefit, or any other similar benefit for which payments or assistance are provided to an individual, household, or family eligibility unit." Under section 432, providers of a non-exempt "Federal public benefit" must verify that a person applying for the benefit is a qualified alien and is eligible to receive the benefit. The HHS programs that provide "Federal public benefits" and are not otherwise excluded from the definition by the exceptions provided in section 401(b) are: Adoption Assistance Administration on Developmental Disabilities (ADD)-State Developmental Disabilities Councils (direct services only) ADD-Special Projects (direct services only) ADD-University Affiliated Programs (clinical disability assessment services only) Adult Programs/Payments to Territories Agency for Health Care Policy and Research Dissertation Grants Child Care and Development Fund Clinical Training Grant for Faculty Development in Alcohol & Drug Abuse Foster Care Health Profession Education and Training Assistance Independent Living Program Job Opportunities for Low Income Individuals (JOLI) Low Income Home Energy Assistance Program (LIHEAP) Medicare Medicaid (except assistance for an emergency medical condition) Mental Health Clinical

  3. RF merger and acquisition market

    Directory of Open Access Journals (Sweden)

    Evgeniya V. Vidishcheva

    2011-04-01

    Full Text Available The article gives brief characteristic of merger and acquisition market situation in Russia, brings in overview of bargains in 2009–2010. Russian merger and acquisition market is in early stage of development.

  4. RF merger and acquisition market

    OpenAIRE

    Evgeniya V. Vidishcheva; Merab S. Sichinava; Marina V. Kogan

    2011-01-01

    The article gives brief characteristic of merger and acquisition market situation in Russia, brings in overview of bargains in 2009–2010. Russian merger and acquisition market is in early stage of development.

  5. UC Merced NMR Instrumentation Acquisition

    Science.gov (United States)

    2015-06-18

    UC Merced NMR Instrumentation Acquisition For the UC Merced NMR Instrumentation Acquisition proposal, a new 400 MHz and an upgraded 500 MHz NMR ...UC Merced NMR Instrumentation Acquisition Report Title For the UC Merced NMR Instrumentation Acquisition proposal, a new 400 MHz and an upgraded 500...MHz NMR have been delivered, installed, and incorporated into research and two lab courses. While no results from these instruments have been

  6. Locative Terms and Warlpiri Acquisition.

    Science.gov (United States)

    Bavin, Edith L.

    1990-01-01

    Focuses on the influence of language specific properties in the acquisition of locative expressions. Some of the claims from literature on the acquisition of locative expressions are discussed and data from the acquisition of Warlpiri are presented and discussed in terms of these claims. (Author/CB)

  7. First Language Acquisition and Teaching

    Science.gov (United States)

    Cruz-Ferreira, Madalena

    2011-01-01

    "First language acquisition" commonly means the acquisition of a single language in childhood, regardless of the number of languages in a child's natural environment. Language acquisition is variously viewed as predetermined, wondrous, a source of concern, and as developing through formal processes. "First language teaching" concerns schooling in…

  8. First Language Acquisition and Teaching

    Science.gov (United States)

    Cruz-Ferreira, Madalena

    2011-01-01

    "First language acquisition" commonly means the acquisition of a single language in childhood, regardless of the number of languages in a child's natural environment. Language acquisition is variously viewed as predetermined, wondrous, a source of concern, and as developing through formal processes. "First language teaching" concerns schooling in…

  9. Unsupervised Language Acquisition

    CERN Document Server

    De Marcken, C

    1996-01-01

    This thesis presents a computational theory of unsupervised language acquisition, precisely defining procedures for learning language from ordinary spoken or written utterances, with no explicit help from a teacher. The theory is based heavily on concepts borrowed from machine learning and statistical estimation. In particular, learning takes place by fitting a stochastic, generative model of language to the evidence. Much of the thesis is devoted to explaining conditions that must hold for this general learning strategy to arrive at linguistically desirable grammars. The thesis introduces a variety of technical innovations, among them a common representation for evidence and grammars, and a learning strategy that separates the ``content'' of linguistic parameters from their representation. Algorithms based on it suffer from few of the search problems that have plagued other computational approaches to language acquisition. The theory has been tested on problems of learning vocabularies and grammars from unse...

  10. Amplitudes, acquisition and imaging

    Energy Technology Data Exchange (ETDEWEB)

    Bloor, Robert

    1998-12-31

    Accurate seismic amplitude information is important for the successful evaluation of many prospects and the importance of such amplitude information is increasing with the advent of time lapse seismic techniques. It is now widely accepted that the proper treatment of amplitudes requires seismic imaging in the form of either time or depth migration. A key factor in seismic imaging is the spatial sampling of the data and its relationship to the imaging algorithms. This presentation demonstrates that acquisition caused spatial sampling irregularity can affect the seismic imaging and perturb amplitudes. Equalization helps to balance the amplitudes, and the dealing strategy improves the imaging further when there are azimuth variations. Equalization and dealiasing can also help with the acquisition irregularities caused by shot and receiver dislocation or missing traces. 2 refs., 2 figs.

  11. Data acquisition instruments: Psychopharmacology

    Energy Technology Data Exchange (ETDEWEB)

    Hartley, D.S. III

    1998-01-01

    This report contains the results of a Direct Assistance Project performed by Lockheed Martin Energy Systems, Inc., for Dr. K. O. Jobson. The purpose of the project was to perform preliminary analysis of the data acquisition instruments used in the field of psychiatry, with the goal of identifying commonalities of data and strategies for handling and using the data in the most advantageous fashion. Data acquisition instruments from 12 sources were provided by Dr. Jobson. Several commonalities were identified and a potentially useful data strategy is reported here. Analysis of the information collected for utility in performing diagnoses is recommended. In addition, further work is recommended to refine the commonalities into a directly useful computer systems structure.

  12. Stock market driven acquisitions

    OpenAIRE

    Shleifer, Andrei; Vishny, Robert W.

    2003-01-01

    We present a model of mergers and acquisitions based on stock market misvaluations of the combining firms. The key ingredients of the model are the relative valuations of the merging firms and the market’s perception of the synergies from the combination. The model explains who acquires whom, the choice of the medium of payment, the valuation consequences of mergers, and merger waves. The model is consistent with available empirical findings about characteristics and returns of merging firms,...

  13. Stock Market Driven Acquisitions

    OpenAIRE

    Andrei Shleifer; Vishny, Robert W.

    2001-01-01

    We present a model of mergers and acquisitions based on stock market misvaluations of the combining firms. The key ingredients of the model are the relative valuations of the merging firms, the horizons of their respective managers, and the market's perception of the synergies from the combination. The model explains who acquirers whom, whether the medium of payment is cash or stock, what are the valuation consequences of mergers, and why there are merger waves. The model is consistent with a...

  14. Defense ADP Acquisition Study.

    Science.gov (United States)

    1981-11-30

    Government Operations Committee HOI - Headquarters Operating Tnstructions vii HOL - Higher Order Language HQ - Headquarters HW - Hardware I IFB...generates lengthy acquisition times, but rather, the basis for the delays is related to the Air Force acqusition process. -5- (2) The Current Air...information resources is stressed, the Senate language in the bill, and the specific wording in the law, dis- claim an expansion of GSA’s authority, as defined

  15. Second language acquisition

    OpenAIRE

    Indefrey, P; Davidson, D.

    2014-01-01

    This article reviews neurocognitive evidence on second language (L2) processing at speech sound, word, and sentence levels. Hemodynamic (functional magnetic resonance imaging and positron emission tomography) data suggest that L2s are implemented in the same brain structures as the native language but with quantitative differences in the strength of activation that are modulated by age of L2 acquisition and L2 proficiency. Electrophysiological data show a more complex pattern of first and L2 ...

  16. Language Acquisition in Computers

    OpenAIRE

    Belzner, Megan; Colin-Ellerin, Sean; Roman, Jorge H.

    2012-01-01

    This project explores the nature of language acquisition in computers, guided by techniques similar to those used in children. While existing natural language processing methods are limited in scope and understanding, our system aims to gain an understanding of language from first principles and hence minimal initial input. The first portion of our system was implemented in Java and is focused on understanding the morphology of language using bigrams. We use frequency distributions and differ...

  17. Second language acquisition

    OpenAIRE

    Indefrey, P.; Davidson, D.

    2014-01-01

    This article reviews neurocognitive evidence on second language (L2) processing at speech sound, word, and sentence levels. Hemodynamic (functional magnetic resonance imaging and positron emission tomography) data suggest that L2s are implemented in the same brain structures as the native language but with quantitative differences in the strength of activation that are modulated by age of L2 acquisition and L2 proficiency. Electrophysiological data show a more complex pattern of first and L2 ...

  18. Assessment of language acquisition.

    Science.gov (United States)

    de Villiers, Peter A; de Villiers, Jill G

    2010-03-01

    This review addresses questions of what should be assessed in language acquisition, and how to do it. The design of a language assessment is crucially connected to its purpose, whether for diagnosis, development of an intervention plan, or for research. Precise profiles of language strengths and weaknesses are required for clear definitions of the phenotypes of particular language and neurodevelopmental disorders. The benefits and costs of formal tests versus language sampling assessments are reviewed. Content validity, theoretically and empirically grounded in child language acquisition, is claimed to be centrally important for appropriate assessment. Without this grounding, links between phenomena can be missed, and interpretations of underlying difficulties can be compromised. Sensitivity and specificity of assessment instruments are often assessed using a gold standard of existing tests and diagnostic practices, but problems arise if that standard is biased against particular groups or dialects. The paper addresses the issues raised by the goal of unbiased assessment of children from diverse linguistic and cultural backgrounds, especially speakers of non-mainstream dialects or bilingual children. A variety of new approaches are discussed for language assessment, including dynamic assessment, experimental tools such as intermodal preferential looking, and training studies that assess generalization. Stress is placed on the need for measures of the process of acquisition rather than just levels of achievement. Copyright © 2010 John Wiley & Sons, Ltd. For further resources related to this article, please visit the WIREs website. Copyright © 2010 John Wiley & Sons, Ltd.

  19. Second language acquisition.

    Science.gov (United States)

    Juffs, Alan

    2011-05-01

    Second language acquisition (SLA) is a field that investigates child and adult SLA from a variety of theoretical perspectives. This article provides a survey of some key areas of concern including formal generative theory and emergentist theory in the areas of morpho-syntax and phonology. The review details the theoretical stance of the two different approaches to the nature of language: generative linguistics and general cognitive approaches. Some results of key acquisition studies from the two theoretical frameworks are discussed. From a generative perspective, constraints on wh-movement, feature geometry and syllable structure, and morphological development are highlighted. From a general cognitive point of view, the emergence of tense and aspect marking from a prototype account of inherent lexical aspect is reviewed. Reference is made to general cognitive learning theories and to sociocultural theory. The article also reviews individual differences research, specifically debate on the critical period in adult language acquisition, motivation, and memory. Finally, the article discusses the relationship between SLA research and second language pedagogy. Suggestions for further reading from recent handbooks on SLA are provided. WIREs Cogni Sci 2011 2 277-286 DOI: 10.1002/wcs.106 For further resources related to this article, please visit the WIREs website. Copyright © 2010 John Wiley & Sons, Ltd.

  20. Complexity in language acquisition.

    Science.gov (United States)

    Clark, Alexander; Lappin, Shalom

    2013-01-01

    Learning theory has frequently been applied to language acquisition, but discussion has largely focused on information theoretic problems-in particular on the absence of direct negative evidence. Such arguments typically neglect the probabilistic nature of cognition and learning in general. We argue first that these arguments, and analyses based on them, suffer from a major flaw: they systematically conflate the hypothesis class and the learnable concept class. As a result, they do not allow one to draw significant conclusions about the learner. Second, we claim that the real problem for language learning is the computational complexity of constructing a hypothesis from input data. Studying this problem allows for a more direct approach to the object of study--the language acquisition device-rather than the learnable class of languages, which is epiphenomenal and possibly hard to characterize. The learnability results informed by complexity studies are much more insightful. They strongly suggest that target grammars need to be objective, in the sense that the primitive elements of these grammars are based on objectively definable properties of the language itself. These considerations support the view that language acquisition proceeds primarily through data-driven learning of some form.

  1. The NUSTAR data acquisition

    Energy Technology Data Exchange (ETDEWEB)

    Loeher, B.; Toernqvist, H.T. [TU Darmstadt (Germany); GSI (Germany); Agramunt, J. [IFIC, CSIC (Spain); Bendel, M.; Gernhaeuser, R.; Le Bleis, T.; Winkel, M. [TU Muenchen (Germany); Charpy, A.; Heinz, A.; Johansson, H.T. [Chalmers University of Technology (Sweden); Coleman-Smith, P.; Lazarus, I.H.; Pucknell, V.F.E. [STFC Daresbury (United Kingdom); Czermak, A. [IFJ (Poland); Kurz, N.; Nociforo, C.; Pietri, S.; Schaffner, H.; Simon, H. [GSI (Germany); Scheit, H. [TU Darmstadt (Germany); Taieb, J. [CEA (France)

    2015-07-01

    The diversity of upcoming experiments within the NUSTAR collaboration, including experiments in storage rings, reactions at relativistic energies and high-precision spectroscopy, is reflected in the diversity of the required detection systems. A challenging task is to incorporate the different needs of individual detectors within the unified NUSTAR Data AcQuisition (NDAQ). NDAQ takes up this challenge by providing a high degree of availability via continuously running systems, high flexibility via experiment-specific configuration files for data streams and trigger logic, distributed timestamps and trigger information on km distances, all built on the solid basis of the GSI Multi-Branch System. NDAQ ensures interoperability between individual NUSTAR detectors and allows merging of formerly separate data streams according to the needs of all experiments, increasing reliability in NUSTAR data acquisition. An overview of the NDAQ infrastructure and the current progress is presented. The NUSTAR (NUclear STructure, Astrophysics and Reactions) collaboration represents one of the four pillars motivating the construction of the international FAIR facility. The diversity of NUSTAR experiments, including experiments in storage rings, reactions at relativistic energies and high-precision spectroscopy, is reflected in the diversity of the required detection systems. A challenging task is to incorporate the different needs of individual detectors and components under the umbrella of the unified NUSTAR Data AQuisition (NDAQ) infrastructure. NDAQ takes up this challenge by providing a high degree of availability via continuously running systems, high flexibility via experiment-specific configuration files for data streams and trigger logic, and distributed time stamps and trigger information on km distances, all built on the solid basis of the GSI Multi-Branch System (MBS). NDAQ ensures interoperability between individual NUSTAR detectors and allows merging of formerly separate

  2. First language acquisition.

    Science.gov (United States)

    Goodluck, Helen

    2011-01-01

    This article reviews current approaches to first language acquisition, arguing in favor of the theory that attributes to the child an innate knowledge of universal grammar. Such knowledge can accommodate the systematic nature of children's non-adult linguistic behaviors. The relationships between performance devices (mechanisms for comprehension and production of speech), non-linguistic aspects of cognition, and child grammars are also discussed. WIREs Cogn Sci 2011 2 47-54 DOI: 10.1002/wcs.95 For further resources related to this article, please visit the WIREs website. Copyright © 2010 John Wiley & Sons, Ltd.

  3. Unsupervised Language Acquisition

    Science.gov (United States)

    de Marcken, Carl

    1996-11-01

    This thesis presents a computational theory of unsupervised language acquisition, precisely defining procedures for learning language from ordinary spoken or written utterances, with no explicit help from a teacher. The theory is based heavily on concepts borrowed from machine learning and statistical estimation. In particular, learning takes place by fitting a stochastic, generative model of language to the evidence. Much of the thesis is devoted to explaining conditions that must hold for this general learning strategy to arrive at linguistically desirable grammars. The thesis introduces a variety of technical innovations, among them a common representation for evidence and grammars, and a learning strategy that separates the ``content'' of linguistic parameters from their representation. Algorithms based on it suffer from few of the search problems that have plagued other computational approaches to language acquisition. The theory has been tested on problems of learning vocabularies and grammars from unsegmented text and continuous speech, and mappings between sound and representations of meaning. It performs extremely well on various objective criteria, acquiring knowledge that causes it to assign almost exactly the same structure to utterances as humans do. This work has application to data compression, language modeling, speech recognition, machine translation, information retrieval, and other tasks that rely on either structural or stochastic descriptions of language.

  4. Data-acquisition systems

    Energy Technology Data Exchange (ETDEWEB)

    Cyborski, D.R.; Teh, K.M.

    1995-08-01

    Up to now, DAPHNE, the data-acquisition system developed for ATLAS, was used routinely for experiments at ATLAS and the Dynamitron. More recently, the Division implemented 2 MSU/DAPHNE systems. The MSU/DAPHNE system is a hybrid data-acquisition system which combines the front-end of the Michigan State University (MSU) DA system with the traditional DAPHNE back-end. The MSU front-end is based on commercially available modules. This alleviates the problems encountered with the DAPHNE front-end which is based on custom designed electronics. The first MSU system was obtained for the APEX experiment and was used there successfully. A second MSU front-end, purchased as a backup for the APEX experiment, was installed as a fully-independent second MSU/DAPHNE system with the procurement of a DEC 3000 Alpha host computer, and was used successfully for data-taking in an experiment at ATLAS. Additional hardware for a third system was bought and will be installed. With the availability of 2 MSU/DAPHNE systems in addition to the existing APEX setup, it is planned that the existing DAPHNE front-end will be decommissioned.

  5. Collection assessment and acquisitions budgets

    CERN Document Server

    Lee, Sul H

    2013-01-01

    This invaluable new book contains timely information about the assessment of academic library collections and the relationship of collection assessment to acquisition budgets. The rising cost of information significantly influences academic libraries'abilities to acquire the necessary materials for students and faculty, and public libraries'abilities to acquire material for their clientele. Collection Assessment and Acquisitions Budgets examines different aspects of the relationship between the assessment of academic library collections and the management of library acquisition budgets. Librar

  6. AN OVERVIEW ON THE DETERMINANTS OF MERGERS AND ACQUISITIONS WAVES

    Directory of Open Access Journals (Sweden)

    Vancea Mariana

    2012-12-01

    Full Text Available This paper concentrates on the presentation of the economic dimension of the mergers and acquisitions from a macroeconomic perspective. Thus, the objective of this paper is to reveal the main drivers of merger and acquisition activity. These operations take place in waves, which enters the context of changing the competition game marked by economic changes, technological evolutions, changes generated by the phenomenon of globalization, and by regulating changes. On the other side, a series of studies in the literature argue the existence of a connection between evaluating the securities and the merger and acquisition activity. This research is based on a systematic, logical and comparative analysis of scientific literature regarding the macroeconomic determinants of mergers and acquisitions.

  7. Language Acquisition in Computers

    CERN Document Server

    Belzner, Megan; Roman, Jorge H

    2012-01-01

    This project explores the nature of language acquisition in computers, guided by techniques similar to those used in children. While existing natural language processing methods are limited in scope and understanding, our system aims to gain an understanding of language from first principles and hence minimal initial input. The first portion of our system was implemented in Java and is focused on understanding the morphology of language using bigrams. We use frequency distributions and differences between them to define and distinguish languages. English and French texts were analyzed to determine a difference threshold of 55 before the texts are considered to be in different languages, and this threshold was verified using Spanish texts. The second portion of our system focuses on gaining an understanding of the syntax of a language using a recursive method. The program uses one of two possible methods to analyze given sentences based on either sentence patterns or surrounding words. Both methods have been i...

  8. Theories of language acquisition.

    Science.gov (United States)

    Vetter, H J; Howell, R W

    1971-03-01

    Prior to the advent of generative grammar, theoretical approaches to language development relied heavily upon the concepts ofdifferential reinforcement andimitation. Current studies of linguistic acquisition are largely dominated by the hypothesis that the child constructs his language on the basis of a primitive grammar which gradually evolves into a more complex grammar. This approach presupposes that the investigator does not impose his own grammatical rules on the utterances of the child; that the sound system of the child and the rules he employs to form sentences are to be described in their own terms, independently of the model provided by the adult linguistic community; and that there is a series of steps or stages through which the child passes on his way toward mastery of the adult grammar in his linguistic environment. This paper attempts to trace the development of human vocalization through prelinguistic stages to the development of what can be clearly recognized as language behavior, and then progresses to transitional phases in which the language of the child begins to approximate that of the adult model. In the view of the authors, the most challenging problems which confront theories of linguistic acquisition arise in seeking to account for structure of sound sequences, in the rules that enable the speaker to go from meaning to sound and which enable the listener to go from sound to meaning. The principal area of concern for the investigator, according to the authors, is the discovery of those rules at various stages of the learning process. The paper concludes with a return to the question of what constitutes an adequate theory of language ontogenesis. It is suggested that such a theory will have to be keyed to theories of cognitive development and will have to include and go beyond a theory which accounts for adult language competence and performance, since these represent only the terminal stage of linguistic ontogenesis.

  9. LEGAL CONSEQUENCES OF MERGERS AND ACQUISITIONS

    Directory of Open Access Journals (Sweden)

    Amelia-Raluca ONIŞOR

    2016-05-01

    Full Text Available The research analyses the legal effects of mergers and acquisitions from the Romanian Company Law perspective, underlining certain general principles, the procedure of annulment of such a legal transformation of companies and the protection of the employees of companies participating in the merger according to the Law no. 67/2006. These consequences of mergers and acquisions are to be seen in the broader light of the most important purpose of this legal instrument, maximizing financial and organizational efficiencies, thus legal certainty is a desirable goal to be assumed by any merger regulation.

  10. First and Second Language Acquisition

    Institute of Scientific and Technical Information of China (English)

    任海燕

    2007-01-01

    Though there are similarities between child first language acquisition and adult second language acquisition,this paper explores the differences between these two processes from several aspects and gives the suggestions that how we language teachers teach L2 students well in language teaching.

  11. Markedness and Second Language Acquisition.

    Science.gov (United States)

    Gil-Byeon, Ja

    1999-01-01

    Discusses whether markedness is at work in second-language acquisition in the same way it is in first-language acquisition when Korean speakers learn English as a second language and English speakers learn Korean as a second language. Results are discussed in terms of no access to universal grammar, partial access to universal grammar, and access…

  12. Universals of Second Language Acquisition.

    Science.gov (United States)

    Eckman, Fred R., Ed.; And Others

    Works on second language acquisition theories, affective variables and communicative competence, and interlanguage were compiled as a result of a symposium on universals of second language acquisition at the University of Wisconsin, Milwaukee. The papers include: "On the Variability of Interlangauge Systems" (Elaine Tarone); "Memory, Learning, and…

  13. Investment and Second Language Acquisition

    Science.gov (United States)

    Pittaway, Daniel S.

    2004-01-01

    The article argues that Norton Peirce's (1995) concept of a language learner's investment should figure centrally in how instructors address the needs of adult learners in ESL classrooms. Investment is discussed in relation to second language acquisition research that addresses the role of social factors in second language acquisition. The article…

  14. Language Acquisition, Pidgins and Creoles.

    Science.gov (United States)

    Wode, Henning

    1981-01-01

    Suggests that structural universals between different-based pidgins result from universal linguo-cognitive processing strategies which are employed in learning languages. Some of the strategies occur in all types of acquisition, and others are more applicable to L2 type acquisition. Past research is discussed, and some exemplary data are given.…

  15. 32 CFR 644.88 - Other acquisition.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Other acquisition. 644.88 Section 644.88 National... HANDBOOK Acquisition Acquisition by Purchase, Donation, and Transfer § 644.88 Other acquisition. (a) Acquisition from other Federal departments and agencies—(1) Transfers. Transfers will be obtained from...

  16. 23 CFR 710.501 - Early acquisition.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Early acquisition. 710.501 Section 710.501 Highways... REAL ESTATE Property Acquisition Alternatives § 710.501 Early acquisition. (a) Real property acquisition. The State may initiate acquisition of real property at any time it has the legal authority to...

  17. 24 CFR 583.105 - Grants for acquisition and rehabilitation.

    Science.gov (United States)

    2010-04-01

    ... rehabilitation. 583.105 Section 583.105 Housing and Urban Development Regulations Relating to Housing and Urban....105 Grants for acquisition and rehabilitation. (a) Use. HUD will grant funds to recipients to: (1) Pay... supportive services; (2) Pay a portion of the cost of rehabilitation of structures, including...

  18. 5 CFR 315.503 - Acquisition of competitive status.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Acquisition of competitive status. 315.503 Section 315.503 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CAREER AND CAREER-CONDITIONAL EMPLOYMENT Career or Career-Conditional Employment by Transfer § 315.503...

  19. 5 CFR 315.302 - Acquisition of competitive status.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Acquisition of competitive status. 315.302 Section 315.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CAREER AND CAREER-CONDITIONAL EMPLOYMENT Career or Career-Conditional Employment From Registers § 315.302...

  20. Defense Acquisition Reform: Background, Analysis, and Issues for Congress

    Science.gov (United States)

    2014-05-23

    Service 15 because it is expected to be approved more easily. BBP 2.0, like BBP 1.0, is not rigid dogma —it is guidance subject to professional...increased complexity of technology and weapon systems, and inclusion of public policy goals into the acquisition process. Examples of regulations that

  1. Reforming the Defense Acquisition System: This Time Must Be Different!

    Science.gov (United States)

    2015-05-13

    acqusition processes and regulations  1981:Acquisition Improvement Plan: decentralized approach  Increased role for the Services in PPBS  Promoted...or development  Developing system-of-systems compounds the mangement challenges; but makes sense to plan for (vs. sole focus on individual

  2. Agile Methods: Selected DoD Management and Acquisition Concerns

    Science.gov (United States)

    2011-10-01

    20, 40 or 100 (an adaptation of a Fibonacci series). Other Agile estimation techniques use similar scales. The spacing between the point values is...acquisition life cycle regulations that provides explicit guidance on contents and sequencing of technical milestones in a program using Agile would

  3. 48 CFR 653.217-70 - DOS form DS-1921, Award/Modification of Interagency Acquisition Agreement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false DOS form DS-1921, Award... Regulations System DEPARTMENT OF STATE CLAUSES AND FORMS FORMS Prescription of Forms 653.217-70 DOS form DS-1921, Award/Modification of Interagency Acquisition Agreement. As prescribed in 617.504-70(b)(5)(i), DS...

  4. 48 CFR 1.109 - Statutory acquisition-related dollar thresholds-adjustment for inflation.

    Science.gov (United States)

    2010-10-01

    ... calculated every 5 years, starting in October 2005, using the Consumer Price Index (CPI) for all-urban...-related dollar thresholds-adjustment for inflation. 1.109 Section 1.109 Federal Acquisition Regulations..., Issuance 1.109 Statutory acquisition-related dollar thresholds—adjustment for inflation. (a) 41 U.S.C. 431a...

  5. 48 CFR 201.109 - Statutory acquisition-related dollar thresholds-adjustment for inflation.

    Science.gov (United States)

    2010-10-01

    ...-related dollar thresholds-adjustment for inflation. 201.109 Section 201.109 Federal Acquisition... REGULATIONS SYSTEM Purpose, Authority, Issuance 201.109 Statutory acquisition-related dollar thresholds-adjustment for inflation. (d) A matrix showing the most recent escalation adjustments of...

  6. 78 FR 16479 - Acquisition of Items for Which Federal Prison Industries Has a Significant Market Share

    Science.gov (United States)

    2013-03-15

    ... Defense Acquisition Regulations System Acquisition of Items for Which Federal Prison Industries Has a... annual list of product categories for which the Federal Prison Industries' share of the DoD Market is... Prison Industries, Inc. (FPI) by requiring DoD to publish an annual list of product categories for...

  7. 77 FR 8843 - Acquisition of Items for Which Federal Prison Industries Has a Significant Market Share

    Science.gov (United States)

    2012-02-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Defense Acquisition Regulations System Acquisition of Items for Which Federal Prison Industries Has a... Prison Industries' share of the DoD market is greater than five percent. DATES: Effective Date:...

  8. 48 CFR 252.225-7038 - Restriction on Acquisition of Air Circuit Breakers.

    Science.gov (United States)

    2010-10-01

    ... of Air Circuit Breakers. 252.225-7038 Section 252.225-7038 Federal Acquisition Regulations System... Circuit Breakers. As prescribed in 225.7006-4(b), use the following clause: Restriction on Acquisition of Air Circuit Breakers (JUN 2005) Unless otherwise specified in its offer, the Contractor shall...

  9. 48 CFR 1.102 - Statement of guiding principles for the Federal Acquisition System.

    Science.gov (United States)

    2010-10-01

    ... communities but also the customers they serve, and the contractors who provide the products and services. (d... judgment in providing the best value product or service to meet the customer's needs. In exercising... principles for the Federal Acquisition System. 1.102 Section 1.102 Federal Acquisition Regulations...

  10. 48 CFR 2419.503 - Setting aside a class of acquisitions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Setting aside a class of... DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 2419.503 Setting aside a class of acquisitions. (a) Class set-aside for construction under the Acquired Property...

  11. 48 CFR 908.7101-6 - Acquisition of fuel-efficient vehicles.

    Science.gov (United States)

    2010-10-01

    ...-efficient vehicles. 908.7101-6 Section 908.7101-6 Federal Acquisition Regulations System DEPARTMENT OF... Items 908.7101-6 Acquisition of fuel-efficient vehicles. (a) All purchases of sedans and station wagons... Activities will submit annually to the Director, Office of Property Management, within the...

  12. 48 CFR 222.403-4 - Department of Labor regulations.

    Science.gov (United States)

    2010-10-01

    ... ACQUISITIONS Labor Standards for Contracts Involving Construction 222.403-4 Department of Labor regulations. Direct all questions regarding Department of Labor regulations to the labor advisor. ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Department of...

  13. DATA ACQUISITION (DAQ)

    CERN Multimedia

    Gerry Bauer

    The CMS Storage Manager System The tail-end of the CMS Data Acquisition System is the Storage Manger (SM), which collects output from the HLT and stages the data at Cessy for transfer to its ultimate home in the Tier-0 center. A SM system has been used by CMS for several years with the steadily evolving software within the XDAQ framework, but until relatively recently, only with provisional hardware. The SM is well known to much of the collaboration through the ‘MiniDAQ’ system, which served as the central DAQ system in 2007, and lives on in 2008 for dedicated sub-detector commissioning. Since March of 2008 a first phase of the final hardware was commissioned and used in CMS Global Runs. The system originally planned for 2008 aimed at recording ~1MB events at a few hundred Hz. The building blocks to achieve this are based on Nexsan's SATABeast storage array - a device  housing up to 40 disks of 1TB each, and possessing two controllers each capable of almost 200 MB/sec throughput....

  14. Foreign Acquisition, Wages and Productivity

    DEFF Research Database (Denmark)

    Bandick, Roger

    This paper studies the effect of foreign acquisition on wages and total factor productivity (TFP) in the years following a takeover by using unique detailed firm-level data for Sweden for the period 1993-2002. The paper takes particular account of the potential endogeneity of the acquisition...... no effects on overall, skilled or less-skilled wage growth neither in targeted Swedish MNEs nor in targeted Swedish non-MNEs and neither if the acquisition was motivated by vertical or horizontal motives. However, the results indicate that both targeted Swedish MNEs and non-MNEs have better growth in TFP...

  15. Foreign Acquisition, Wages and Productivity

    DEFF Research Database (Denmark)

    Bandick, Roger

    2011-01-01

    This paper studies the effect of foreign acquisition on wages and total factor productivity (TFP) in the years following a takeover by using unique detailed firm-level data for Sweden for the period 1993-2002. The paper takes particular account of the potential endogeneity of the acquisition...... no effects on overall, skilled or less-skilled wage growth neither in targeted Swedish MNEs nor in targeted Swedish non-MNEs and neither if the acquisition was motivated by vertical or horizontal motives. However, the results indicate that both targeted Swedish MNEs and non-MNEs have better growth in TFP...

  16. Data acquisition techniques using PC

    CERN Document Server

    Austerlitz, Howard

    1991-01-01

    Data Acquisition Techniques Using Personal Computers contains all the information required by a technical professional (engineer, scientist, technician) to implement a PC-based acquisition system. Including both basic tutorial information as well as some advanced topics, this work is suitable as a reference book for engineers or as a supplemental text for engineering students. It gives the reader enough understanding of the topics to implement a data acquisition system based on commercial products. A reader can alternatively learn how to custom build hardware or write his or her own software.

  17. 48 CFR 304.803-70 - Contract/order file organization and use of checklists.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract/order file organization and use of checklists. 304.803-70 Section 304.803-70 Federal Acquisition Regulations System HEALTH... content of HHS contract and order files, OPDIVs shall use the folder filing system and accompanying...

  18. 48 CFR 311.7000 - Defining electronic information technology requirements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Defining electronic information technology requirements. 311.7000 Section 311.7000 Federal Acquisition Regulations System HEALTH... Accessibility Standards 311.7000 Defining electronic information technology requirements. HHS staff that...

  19. 48 CFR 313.303-5 - Purchases under blanket purchase agreements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Purchases under blanket purchase agreements. 313.303-5 Section 313.303-5 Federal Acquisition Regulations System HEALTH AND HUMAN... Methods 313.303-5 Purchases under blanket purchase agreements. (e)(5) HHS personnel that sign...

  20. 48 CFR 301.606-73 - Requirements for continuous learning maintenance.

    Science.gov (United States)

    2010-10-01

    ... continuous learning maintenance. 301.606-73 Section 301.606-73 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 301.606-73 Requirements for continuous learning maintenance. Designated...