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Sample records for hhh hhh hhh

  1. What if $\\lambda_{hhh}\

    CERN Document Server

    Efrati, Aielet

    2014-01-01

    A measurement of the Higgs trilinear self coupling $\\lambda_{hhh}$ will test the Standard Model Higgs potential. But can it reveal information that cannot be learned otherwise? By analyzing several simple extensions of the Standard Model scalar sector we show that this measurement might give a first hint for New Physics modifying the electroweak symmetry breaking. Combining the measurements of $\\lambda_{hhh}$ and $\\lambda_{hVV}$ ($V=W,Z$) is particularly powerful in distinguishing between various models of New Physics and in providing unique information on these models.

  2. 40 CFR Appendix: Table 1 to... - List of Hazardous Air Pollutants (HAP) for Subpart HHH

    Science.gov (United States)

    2010-07-01

    ...) for Subpart HHH Table Appendix: Table 1 to Subpart HHH of Part 63 Protection of Environment... Natural Gas Transmission and Storage Facilities Pt. 63, Subpt. HHH, Table 1 Appendix: Table 1 to Subpart HHH of Part 63—List of Hazardous Air Pollutants (HAP) for Subpart HHH CAS Number a Chemical name...

  3. hhh Coupling in SUSY models after LHC run I

    CERN Document Server

    Wu, Lei; Yuan, Chien-Peng; Zhang, Mengchao

    2015-01-01

    We examine the Higgs triple coupling in MSSM and NMSSM under current constraints, which include the LHC measurements, Higgs data, B physics, electroweak precision observables, relic density and so on. The ratio $\\lambda^{\\rm MSSM}_{hhh}/\\lambda^{\\rm SM}_{hhh}$ is above 0.97, due to the highly constrained parameter space. While the ratio $\\lambda^{\\rm NMSSM}_{hhh}/\\lambda^{\\rm SM}_{hhh}$ can reach 0.1 under current constraints. The precise measurement in future collider will give a tighter constraint to the Higgs triple coupling in MSSM and NMSSM.

  4. 40 CFR Table 2 to Subpart Hhh of... - Toxic Equivalency Factors

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Toxic Equivalency Factors 2 Table 2 to Subpart HHH of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS..., Subpt. HHH, Table 2 Table 2 to Subpart HHH of Part 62—Toxic Equivalency Factors Dioxin/furan...

  5. Tests of Higgs boson compositeness through the HHH form factor

    CERN Document Server

    Gounaris, G J

    2015-01-01

    We show how the $q^2$-dependence of the triple Higgs boson HHH form factor can reveal the presence of various types of new physics contributions, like new particles coupled to the Higgs boson or Higgs boson constituents, without directly observing them. We compare the effect of such new contributions to the one of higher order SM corrections to the point-like HHH coupling, due to triangle, 4-leg and s.e. diagrams. We establish simple analytic expressions describing accurately at high energy these SM corrections, as well as the examples of new physics contributions.

  6. 40 CFR Appendix: Table 2 to... - Applicability of 40 CFR Part 63 General Provisions to Subpart HHH

    Science.gov (United States)

    2010-07-01

    ... HHH of Part 63—Applicability of 40 CFR Part 63 General Provisions to Subpart HHH General provisions... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Applicability of 40 CFR Part 63 General Provisions to Subpart HHH Table Appendix: Table 2 to Subpart HHH of Part 63 Protection of...

  7. [Molecular genetic studies of mitochondrial ornithine transporter deficiency (HHH syndrome)].

    Science.gov (United States)

    Tsujino, S; Miyamoto, T; Kanazawa, N

    2001-11-01

    Mitochondrial ornithine transporter deficiency has been called HHH syndrome, because this disorder is characterized by three biochemical abnormalities; hyperornithinemia, hyperammonemia, and homocitrullinuria, and presents with various neurological symptoms; mental retardation, spastic paraparesis with pyramidal signs, cerebellar ataxia and episodic disturbance of consciousness or coma due to hyperammonemia. We identified four mutations in the mitochondrial ornithine transporter gene (ORNT1) of Japanese patients with HHH syndrome. These include a nonsense mutation (R179X), associated with exon skipping, missense mutations (G27E, P126R), and an insertion of AAC between codons 228 and 229, leading to an insertion of amino acid Asn. Especially, R179X was detected 4 of 7 Japanese patients (8 of 14 alleles), implying that this is a common mutation in Japanese population.

  8. 40 CFR Appendix A to Subpart Hhh... - Exempted Aquifers in New Mexico

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Exempted Aquifers in New Mexico A Appendix A to Subpart HHH of Part 147 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Appendix A to Subpart HHH of Part 147—Exempted Aquifers in New Mexico The areas described by a...

  9. 40 CFR Table 1 to Subpart Hhh of... - Emission Limits for Small Rural, Small, Medium, and Large HMIWI

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Emission Limits for Small Rural, Small, Medium, and Large HMIWI 1 Table 1 to Subpart HHH of Part 62 Protection of Environment ENVIRONMENTAL... Incinerators Constructed on or Before June 20, 1996 Pt. 62, Subpt. HHH, Table 1 Table 1 to Subpart HHH of...

  10. Abnormal urinary excretion of polyamines in HHH syndrome (hyperornithinemia associated with hyperammonemia and homocitrullinuria).

    Science.gov (United States)

    Shimizu, H; Maekawa, K; Eto, Y

    1990-01-01

    The HHH syndrome (hyperornithinemia associated with hyperammonemia and homocitrullinuria) is characterized by a very rare genetic defect of ornithine transport in mitochondrial membrane. We first demonstrated that a patient with HHH syndrome excreted about 6 times higher amount of polyamines in urine than the control when supplemented with high protein diets and ornithine loading. Each urinary polyamine fraction measured by HPLC method in HHH syndrome appears to be increased, as compared with those of the control. These data suggest that increased urinary excretion of polyamines in this syndrome is closely related to overflowing of plasma polyamine due to an ornithine transport defect in the mitochondrial membrane.

  11. Diagnosis and high incidence of hyperornithinemia-hyperammonemia-homocitrullinemia (HHH) syndrome in northern Saskatchewan.

    Science.gov (United States)

    Sokoro, AbdulRazaq A H; Lepage, Joyce; Antonishyn, Nick; McDonald, Ryan; Rockman-Greenberg, Cheryl; Irvine, James; Lehotay, Denis C

    2010-12-01

    Mutations in the SLC25A15 gene, encoding the human inner mitochondrial membrane ornithine transporter, are thought to be responsible for hyperornithinemia-hyperammonemia-homocitrullinemia (HHH) syndrome, a rare autosomal recessive condition. HHH syndrome has been detected in several small, isolated communities in northern Saskatchewan (SK). To determine the incidence of HHH syndrome in these communities, a PCR method was set up to detect F188Δ, the common French-Canadian mutation. Neonatal blood spots collected from all newborns from the high risk area were genotyped for the F188Δ mutation for seven consecutive years. Using DNA analysis, we estimated that the heterozygote frequency for the mutant allele for HHH syndrome to be about 1 in 19 individuals, predicting one affected child with HHH syndrome for approximately every 1,500 individuals (1 in 1,550 live births; 1 child every 12 years) in this isolated population. The frequency for the mutant allele for HHH syndrome in this isolated community is probably the highest in the world for this rare disorder. We determined that ornithine levels, by tandem mass spectrometry, were not abnormal in newborns with F188Δ mutation, carriers and normals. Ornithine rises to abnormally high levels at some time after birth well past the time that the newborn screening blood spot is collected. The timing or the reasons for the delayed rise of ornithine in affected children with HHH syndrome have not been determined. Newborn screening for HHH Syndrome in this high risk population is only possible by detection of the mutant allele using DNA analysis.

  12. Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH) presenting with acute fulminant hepatic failure.

    Science.gov (United States)

    Mhanni, A A; Chan, A; Collison, M; Seifert, B; Lehotay, D C; Sokoro, Ah; Huynh, H Q; Greenberg, C R

    2008-03-01

    We report on two Aboriginal patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. Both presented with acute hepatic failure with severe hypertransaminasemia and coagulopathy, prompting evaluation for emergent liver transplantation. The diagnosis of HHH syndrome was based on the presence of typical metabolic abnormalities. A protein-restricted diet and L-arginine or L-citrulline supplementation were immediately started, with rapid normalization of liver function test results and other biochemical abnormalities. Molecular analysis of the SLC25A15 gene showed that the two patients were homozygous for the common French Canadian mutation (F188Delta). The diagnosis of HHH syndrome should be considered in patients with unexplained fulminant hepatic failure. There does not appear to be a genotype-phenotype correlation for this presentation, inasmuch as the only other reported patient presenting with this picture had two different point mutations. Early identification and prompt treatment of these patients is crucial to avoid liver transplantation and can be life saving.

  13. HHH syndrome (hyperornithinaemia, hyperammonaemia, homocitrullinuria), with fulminant hepatitis-like presentation.

    Science.gov (United States)

    Fecarotta, S; Parenti, G; Vajro, P; Zuppaldi, A; Della Casa, R; Carbone, M T; Correra, A; Torre, G; Riva, S; Dionisi-Vici, C; Santorelli, F M; Andria, G

    2006-02-01

    We report a 3-year-old Italian patient with the hyperornithinaemia, hyperammonaemia, homocitrullinuria (HHH) syndrome who presented with neurological deterioration after an intercurrent infection. Hyperammonaemia, coagulopathy and moderate hypertransaminasaemia were detected on hospital admission. Severe hepatocellular necrosis with hypertransaminasaemia (aspartate aminotransferase 20,000 UI/L, alanine aminotransferase 18,400 UI/L) and coagulopathy (PT HHH syndrome was based on the presence of the typical metabolic abnormalities. Molecular analysis of the SLC25A15 gene showed that the patient was heterozygous for two novel mutations (G113C and M273K). The diagnosis of HHH syndrome should be considered in patients with fulminant hepatitis-like presentations. Early identification and treatment of these patients can be life-saving and can avoid liver transplantation.

  14. Ultrastructural changes in fibroblast mitochondria of a patient with HHH-syndrome.

    Science.gov (United States)

    Metoki, K; Hommes, F A; Dyken, P; Kelloes, C; Trefz, J

    1984-01-01

    Electron micrographs of fibroblasts of an HHH-syndrome patient showed abnormal structures, similar, but not identical, to those observed in the liver of such patients. It is suggested that incorporation of a mutated protein into the inner mitochondrial membrane gives rise to a rearrangement of that membrane, resulting in unusual structures.

  15. The HhH domain of the human DNA repair protein XPF forms stable homodimers.

    Science.gov (United States)

    Das, Devashish; Tripsianes, Konstantinos; Jaspers, Nicolaas G J; Hoeijmakers, Jan H J; Kaptein, Robert; Boelens, Rolf; Folkers, Gert E

    2008-03-01

    The human XPF-ERCC1 protein complex plays an essential role in nucleotide excision repair by catalysing positioned nicking of a DNA strand at the 5' side of the damage. We have recently solved the structure of the heterodimeric complex of the C-terminal domains of XPF and ERCC1 (Tripsianes et al., Structure 2005;13:1849-1858). We found that this complex comprises a pseudo twofold symmetry axis and that the helix-hairpin-helix motif of ERCC1 is required for DNA binding, whereas the corresponding domain of XPF is functioning as a scaffold for complex formation with ERCC1. Despite the functional importance of heterodimerization, the C-terminal domain of XPF can also form homodimers in vitro. We here compare the stabilities of homodimeric and heterodimeric complexes of the C-terminal domains of XPF and ERCC1. The higher stability of the XPF HhH complexes under various experimental conditions, determined using CD and NMR spectroscopy and mass spectrometry, is well explained by the structural differences that exist between the HhH domains of the two complexes. The XPF HhH homodimer has a larger interaction interface, aromatic stacking interactions, and additional hydrogen bond contacts as compared to the XPF/ERCC1 HhH complex, which accounts for its higher stability.

  16. A novel mutation, P126R, in a Japanese patient with HHH syndrome.

    Science.gov (United States)

    Miyamoto, Takeshi; Kanazawa, Naomi; Hayakawa, Chiemi; Tsujino, Seiichi

    2002-01-01

    Mitochondrial ornithine transporter deficiency, or HHH syndrome, is a metabolic disorder resulting in various neurologic symptoms, including mental retardation, spastic paraparesis with pyramidal signs, cerebellar ataxia, and episodic disturbance of consciousness or coma caused by hyperammonemia. Several mutations have been reported in the ORNT1 gene encoding mitochondrial ornithine transporter of patients with this disorder. In this article, we report a new patient, a male 15 years of age, who had typical clinical features of HHH syndrome. Because the patient did not have any of the three mutations previously described in other Japanese patients with HHH syndrome, and the only material available from the patient was peripheral leukocytes, we established a genomic polymerase chain reaction method using intronic primers to amplify every exon of the ORNT1 gene, and we directly sequenced the polymerase chain reaction products. Using this method, we documented a novel mutation in this patient, P126R, and demonstrated that HHH syndrome is genetically heterogeneous, even in the Japanese population.

  17. Clinical and functional characterization of a human ORNT1 mutation (T32R) in the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome.

    Science.gov (United States)

    Camacho, José A; Mardach, Rebecca; Rioseco-Camacho, Natalia; Ruiz-Pesini, Eduardo; Derbeneva, Olga; Andrade, Dario; Zaldivar, Frank; Qu, Yong; Cederbaum, Stephen D

    2006-10-01

    We studied two related families (HHH013 and HHH015) with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, a disorder of the urea cycle and ornithine degradation pathway, who have the same novel ornithine transporter (ORNT1) genotype (T32R) but a variable phenotype. Both HHH015 patients are doing well in school and are clinically stable; conversely, the three affected HHH013 siblings had academic difficulties and one suffered recurrent episodes of hyperammonemia and ultimately died. Overexpression studies revealed that the product of the ORNT1-T32R allele has residual function. Ornithine transport studies in HHH015 fibroblasts, however, showed basal activity similar to fibroblasts carrying nonfunctional ORNT1 alleles. We also examined two potential modifying factors, the ORNT2 gene and the mitochondrial DNA lineage (haplogroup). Haplogroups, associated with specific diseases, are hypothesized to influence mitochondrial function. Results demonstrated that both HHH015 patients are heterozygous for an ORNT2 gain of function polymorphism and belong to haplogroup A whereas the HHH013 siblings carry the wild-type ORNT2 and are haplogroup H. These observations suggest that the ORNT1 genotype cannot predict the phenotype of HHH patients. The reason for the phenotypic variability is unknown, but factors such as redundant transporters and mitochondrial lineage may contribute to the neuropathophysiology of HHH patients.

  18. Conscientious metabolic monitoring on a patient with hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome undergoing anaesthesia.

    Science.gov (United States)

    Mühling, J; Dehne, M G; Fuchs, M; Sablotzki, A; Weiss, S; Spatz, J; Hempelmann, G

    2001-01-01

    Currently we know not more than 50 patients who show an interesting combination of increased plasma ornithine concentrations, postprandial hyperammonemia, and homocitrullinuria (HHH-syndrome). Since exact knowledge of this severe, although rare syndrome is important for any perioperative or intensive medical treatment concerning therapy and progression of the disease, we report a comprehensive study on a 32-year old woman with this rare multifaceted disorder who had to undergo general anaesthesia. For the first time amino acid status in plasma, urine, cerebrospinal fluid and especially polymorphonuclear leucocytes, which in the investigation showed to be valuable tool for evaluating amino acid metabolism in nucleated cells in HHH-syndrome, and further important pathophysiologic indicators of cellular and metabolic function have been conscientiously investigated and compared. The pathophysiological repercussions of our results as well as the recommendations for conscientious therapeutical management are discussed.

  19. Ciliated cultured dermal fibroblasts in a patient with hyperornithinemia, hyperammonemia and homocitrullinuria (HHH) syndrome.

    Science.gov (United States)

    Haust, M D

    1995-10-01

    Hyperornithinemia, hyperammonemia and homocitrullinuria (HHH)-syndrome is a rare autosomal recessive disorder of the urea cycle, probably caused by a defect in ornithine transport across the hepatic inner mitochondrial membrane. Single rudimentary cilia were present in approximately ten percent of post-divisional or dividing fibroblasts cultured from the skin of a patient with the HHH-syndrome, whereas no such organelles were observed in dermal fibroblasts cultured from normal controls. Since single rudimentary ("primary," "oligo," "solitary") cilia have been observed in a variety of cells in animals and men but the stimuli for their formation and their significance remain controversial, a brief report on their presence in the as yet unreported condition (HHH-syndrome) was considered of interest; hopefully, it might contribute to the ultimate unravelling of some of the unresolved problems. It is of note that unlike the author's previous findings of these unusual organelles in cells affected by a pathological process (atherosclerosis), the rudimentary cilia were observed in the present instance in dividing or postdivisional cells. The implications of these (and other) observations must await further work.

  20. Diagnosis of Japanese patients with HHH syndrome by molecular genetic analysis: a common mutation, R179X.

    Science.gov (United States)

    Miyamoto, T; Kanazawa, N; Kato, S; Kawakami, M; Inoue, Y; Kuhara, T; Inoue, T; Takeshita, K; Tsujino, S

    2001-01-01

    Patients with mitochondrial ornithine transporter deficiency (or HHH syndrome) present with various neurological symptoms, including mental retardation, spastic paraparesis with pyramidal signs, cerebellar ataxia, and episodic disturbance of consciousness or coma due to hyperammonemia. We previously described three novel mutations in the ORNT1 gene in Japanese patients with HHH syndrome. In this article, we report a new patient with HHH syndrome, a 52-year-old woman, who had the typical clinical features, except for an absence of mental retardation. When we screened this patient, as well as a previously described Japanese patient, for mutations in the ORNT1 gene, we found that both were homozygous for a nonsense mutation (R179X). Furthermore, reverse transcription (RT)-polymerase chain reaction (PCR) of fibroblast RNA from one patient showed exon 4 skipping, as had been observed in a previously reported patient with R179X. These results, together with the findings in our previous report, show that, in three of our five reported Japanese HHH patients (six of ten alleles), R179X is present, suggesting that this is a common mutation in Japanese patients with HHH syndrome.

  1. Insights into the mutation-induced HHH syndrome from modeling human mitochondrial ornithine transporter-1.

    Directory of Open Access Journals (Sweden)

    Jing-Fang Wang

    Full Text Available Human mitochondrial ornithine transporter-1 is reported in coupling with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH syndrome, which is a rare autosomal recessive disorder. For in-depth understanding of the molecular mechanism of the disease, it is crucially important to acquire the 3D structure of human mitochondrial ornithine transporter-1. Since no such structure is available in the current protein structure database, we have developed it via computational approaches based on the recent NMR structure of human mitochondrial uncoupling protein (Berardi MJ, Chou JJ, et al. Nature 2011, 476:109-113. Subsequently, we docked the ligand L-ornithine into the computational structure to search for the favorable binding mode. It was observed that the binding interaction for the most favorable binding mode is featured by six remarkable hydrogen bonds between the receptor and ligand, and that the most favorable binding mode shared the same ligand-binding site with most of the homologous mitochondrial carriers from different organisms, implying that the ligand-binding sites are quite conservative in the mitochondrial carriers family although their sequences similarity is very low with 20% or so. Moreover, according to our structural analysis, the relationship between the disease-causing mutations of human mitochondrial ornithine transporter-1 and the HHH syndrome can be classified into the following three categories: (i the mutation occurs in the pseudo-repeat regions so as to change the region of the protein closer to the mitochondrial matrix; (ii the mutation is directly affecting the substrate binding pocket so as to reduce the substrate binding affinity; (iii the mutation is located in the structural region closer to the intermembrane space that can significantly break the salt bridge networks of the protein. These findings may provide useful insights for in-depth understanding of the molecular mechanism of the HHH syndrome and

  2. Insights into the mutation-induced HHH syndrome from modeling human mitochondrial ornithine transporter-1.

    Science.gov (United States)

    Wang, Jing-Fang; Chou, Kuo-Chen

    2012-01-01

    Human mitochondrial ornithine transporter-1 is reported in coupling with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, which is a rare autosomal recessive disorder. For in-depth understanding of the molecular mechanism of the disease, it is crucially important to acquire the 3D structure of human mitochondrial ornithine transporter-1. Since no such structure is available in the current protein structure database, we have developed it via computational approaches based on the recent NMR structure of human mitochondrial uncoupling protein (Berardi MJ, Chou JJ, et al. Nature 2011, 476:109-113). Subsequently, we docked the ligand L-ornithine into the computational structure to search for the favorable binding mode. It was observed that the binding interaction for the most favorable binding mode is featured by six remarkable hydrogen bonds between the receptor and ligand, and that the most favorable binding mode shared the same ligand-binding site with most of the homologous mitochondrial carriers from different organisms, implying that the ligand-binding sites are quite conservative in the mitochondrial carriers family although their sequences similarity is very low with 20% or so. Moreover, according to our structural analysis, the relationship between the disease-causing mutations of human mitochondrial ornithine transporter-1 and the HHH syndrome can be classified into the following three categories: (i) the mutation occurs in the pseudo-repeat regions so as to change the region of the protein closer to the mitochondrial matrix; (ii) the mutation is directly affecting the substrate binding pocket so as to reduce the substrate binding affinity; (iii) the mutation is located in the structural region closer to the intermembrane space that can significantly break the salt bridge networks of the protein. These findings may provide useful insights for in-depth understanding of the molecular mechanism of the HHH syndrome and developing effective

  3. Studies on a case of HHH-syndrome (hyperammonemia, hyperornithinemia, homocitrullinuria).

    Science.gov (United States)

    Hommes, F A; Roesel, R A; Metoki, K; Hartlage, P L; Dyken, P R

    1986-02-01

    A patient with the hyperornithinemia, hyperammonemia, homocitrullinuria syndrome is described. This patient represents the 12th documented case of this rare, presumably autosomal recessive condition. Increased levels of ammonia, ornithine and homocitrulline were demonstrated in blood and cerebrospinal fluid. The blood ammonia concentration could be lowered by supplementation of the diet with low doses of arginine. High doses of arginine precipitated seizures, although plasma levels of arginine and ornithine were not altered. The uptake of ornithine by the particulate fraction of the patient's fibroblasts was lower than that of controls, but still measurable. It is suggested that HHH patients have a partial impairment of the uptake of ornithine by mitochondria.

  4. Determination of homocitrulline in urine of patients with HHH syndrome by liquid chromatography tandem mass spectrometry.

    Science.gov (United States)

    Al-Dirbashi, Osama Y; Al-Hassnan, Zuhair N; Rashed, Mohamed S

    2006-12-01

    A liquid chromatography tandem mass spectrometric method is described for the analysis of homocitrulline in human urine, a key metabolite in the differential diagnosis of hyperammonemia, hyperornithinemia, homocitrullinuria (HHH) syndrome. Urine samples were prepared by mere five-fold dilution with a mixture of internal standards (2H2-citrulline and 2H3-creatinine) used for the simultaneous quantification of creatinine. Analytes were separated on a cyano column and eluted isocratically within seven min. Detection was achieved by monitoring transitions of 190 > 84 and 190 > 127 for homocitrulline, 178 > 115 for 2H2-citrulline, 114 > 44 for creatinine and 117 > 47 for 2H3-creatinine. Calibration curves were linear up to 100 micromol/L. Intraday (n = 7) and interday (n = 6) variations were less than 10%. In urine samples from three siblings confirmed to have HHH syndrome, homocitrulline levels were at 13.3 (74), 21.1 (50) and 108.2 (103) mmol/mol creatinine (micromol/L). Control values were 0-9 mmol/mol creatinine (n = 120). The current method solves specificity issues in homocitrulline determination often encountered with some ninhydrin-based systems (coelution with methionine) and some o-phthalaldehyde-based ones (coelution with taurine), and presents an attractive alternative with a relatively high throughput.

  5. Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase.

    Science.gov (United States)

    Wang, Li Kai; Nair, Pravin A; Shuman, Stewart

    2008-08-22

    NAD(+)-dependent DNA ligases (LigAs) are ubiquitous in bacteria and essential for growth. LigA enzymes have a modular structure in which a central catalytic core composed of nucleotidyltransferase and oligonucleotide-binding (OB) domains is linked via a tetracysteine zinc finger to distal helix-hairpin-helix (HhH) and BRCT (BRCA1-like C-terminal) domains. The OB and HhH domains contribute prominently to the protein clamp formed by LigA around nicked duplex DNA. Here we conducted a structure-function analysis of the OB and HhH domains of Escherichia coli LigA by alanine scanning and conservative substitutions, entailing 43 mutations at 22 amino acids. We thereby identified essential functional groups in the OB domain that engage the DNA phosphodiester backbone flanking the nick (Arg(333)); penetrate the minor grove and distort the nick (Val(383) and Ile(384)); or stabilize the OB fold (Arg(379)). The essential constituents of the HhH domain include: four glycines (Gly(455), Gly(489), Gly(521), Gly(553)), which bind the phosphate backbone across the minor groove at the outer margins of the LigA-DNA interface; Arg(487), which penetrates the minor groove at the outer margin on the 3 (R)-OH side of the nick; and Arg(446), which promotes protein clamp formation via contacts to the nucleotidyltransferase domain. We find that the BRCT domain is required in its entirety for effective nick sealing and AMP-dependent supercoil relaxation.

  6. Summary of CARE-HHH Mini-Workshop on LHC Crab Cavity Validation, 21 August 2008

    CERN Document Server

    Calaga, R; Garoby, R; Linnecar, T; Tomás, R; Zimmermann, F; CERN. Geneva. BE Department

    2008-01-01

    A global LHC crab-cavity collaboration is rapidly advancing the R&D of a complete crab cavity cryomodule and performing the associated beam dynamics simulations compatible with a prototype test in the phase 0/I upgrade with the aim of establishing a full crab crossing scheme for the phase II upgrade of the LHC. A one day CARE-HHH mini-workshop was held on August 21, 2008 at CERN to discuss crab crossing in the LHC phase 0/I & II upgrades and this reports summarizes the activities of the four sessions that took place during the workshop. The goals of this crab-cavity workshop were fourfold: (1) to discuss prospects of crab cavities in LHC upgrades (2) to review the status of the cryomodule development and beam dynamics, (3) to establish validity requirements for LHC crab cavities which need to be demonstrated prior to their installation into the LHC, and (4) to provide guidance & coordination for the global collaborators.

  7. Home telemonitoring in heart failure patients: the HHH study (Home or Hospital in Heart Failure)

    Science.gov (United States)

    Mortara, Andrea; Pinna, Gian Domenico; Johnson, Paul; Maestri, Roberto; Capomolla, Soccorso; La Rovere, Maria Teresa; Ponikowski, Piotr; Tavazzi, Luigi; Sleight, Peter

    2009-01-01

    Aims The Home or Hospital in Heart failure (HHH) study was a European Community-funded, multinational, randomized controlled clinical trial, conducted in the UK, Poland, and Italy, to assess the feasibility of a new system of home telemonitoring (HT). The HT system was used to monitor clinical and physiological parameters, and its effectiveness (compared with usual care) in reducing cardiac events in heart failure (HF) patients was evaluated. Measurements were patient-managed. Methods and results From 2002 to 2004, 461 HF patients (age 60 ± 11 years, New York Heart Association class 2.4 ± 0.6, left ventricular ejection fraction 29 ± 7%) were enrolled at 11 centres and randomized (1:2) to either usual outpatient care or HT administered as three randomized strategies: (i) monthly telephone contact; (ii) strategy 1 plus weekly transmission of vital signs; and (iii) strategy 2 plus monthly 24 h recording of cardiorespiratory activity. Patients completed 81% of vital signs transmissions, as well as 92% of cardiorespiratory recordings. Over a 12-month follow-up, there was no significant effect of HT in reducing bed-days occupancy for HF or cardiac death plus HF hospitalization. Post hoc analysis revealed a heterogeneous effect of HT in the three countries with a trend towards a reduction of events in Italy. Conclusion Home or Hospital in Heart failure indicates that self-managed HT of clinical and physiological parameters is feasible in HF patients, with surprisingly high compliance. Whether HT contributes to a reduction of cardiac events requires further investigation. PMID:19228800

  8. A novel R275X mutation of the SLC25A15 gene in a Japanese patient with the HHH syndrome.

    Science.gov (United States)

    Torisu, Hiroyuki; Kira, Ryutaro; Kanazawa, Naomi; Takemoto, Megumi; Sanefuji, Masafumi; Sakai, Yasunari; Tsujino, Seiichi; Hara, Toshiro

    2006-06-01

    The hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome (MIM 238970) is an autosomal recessive metabolic disorder caused by a deficiency of the mitochondrial ornithine transporter, one of the urea cycle components. Mutations in the SLC25A15 gene have been coupled to the HHH syndrome. We describe a Japanese female patient with the HHH syndrome due to a novel homozygous R275X SLC25A15 mutation and male sibling who presumably carried the same mutation. He exhibited slowly progressive deterioration with seizures, a gait disturbance due to polyneuropathy, episodic confusion, and died of acute encephalopathy at 34 years of age while the proband exhibited moderate mental retardation, seizures, mild spastic paraplegia, and deafness without neurological deterioration for more than 20 years. The clinical features of previously documented patients with the homozygous SLC25A15 mutation demonstrated that genotype did not simply correlate with clinical severity. The phenotypic variability might depend on other factors, such as dietary and other genetic ones.

  9. The HhH2/NDD domain of the Drosophila Nod chromokinesin-like protein is required for binding to chromosomes in the oocyte nucleus.

    Science.gov (United States)

    Cui, Wei; Hawley, R Scott

    2005-12-01

    Nod is a chromokinesin-like protein that plays a critical role in segregating achiasmate chromosomes during female meiosis. The C-terminal half of the Nod protein contains two putative DNA-binding domains. The first of these domains, known as the HMGN domain, consists of three tandemly repeated high-mobility group N motifs. This domain was previously shown to be both necessary and sufficient for binding of the C-terminal half of Nod to mitotic chromosomes in embryos. The second putative DNA-binding domain, denoted HhH(2)/NDD, is a helix-hairpin-helix(2)/Nod-like DNA-binding domain. Although the HhH(2)/NDD domain is not required or sufficient for chromosome binding in embryos, several well-characterized nod mutations have been mapped in this domain. To characterize the role of the HhH(2)/NDD domain in mediating Nod function, we created a series of UAS-driven transgene constructs capable of expressing either a wild-type Nod-GFP fusion protein or proteins in which the HhH(2)/NDD domain had been altered by site-directed mutagenesis. Although wild-type Nod-GFP localizes to the oocyte chromosomes and rescues the segregation defect in nod mutant oocytes, two of three proteins carrying mutants in the HhH(2)/NDD domain fail to either rescue the nod mutant phenotype or bind to oocyte chromosomes. However, these mutant proteins do bind to the polytene chromosomes in nurse-cell nuclei and enter the oocyte nucleus. Thus, even though the HhH(2)/NDD domain is not essential for chromosome binding in other cell types, it is required for chromosome binding in the oocyte. These HhH(2)/NDD mutants also block the localization of Nod to the posterior pole of stage 9-10A oocytes, a process that is thought to facilitate the interaction of Nod with the plus ends of microtubules (Cui et al. 2005). This observation suggests that the Nod HhH2/NDD domain may play other roles in addition to binding Nod to meiotic chromosomes.

  10. [A case of hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome with spastic paraparesis and severe distal muscle atrophy of lower limbs].

    Science.gov (United States)

    Shigeto, H; Yamada, T; Kobayashi, T; Goto, I

    1992-07-01

    A 16-year-old boy with hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome was reported. He was the second child of first-cousin consanguineous parents. Since childhood, he was mentally retarded and had frequent episodes of vomiting but no unconsciousness attack. Because of progressive gait disturbance since the age of 15, he was admitted to Kyushu University Hospital. Neurological examination revealed mental defect and spastic paraparesis with bilateral positive pathological reflexes. Moreover, severe muscle atrophy and moderate weakness were observed in the distal portion of lower extremities. The diagnosis of HHH syndrome was made by the examination of amino acids in the serum and urine and by the incorporation study of radioactive ornithine into cultured fibroblasts. EMG and nerve biopsy studies suggested that the muscle atrophy seen in this patient was caused by the degeneration of spinal anterior horn cells. Amino acid imbalance, especially elevation of glutamine and glutamic acid in the CSF, may cause dysfunction of neuronal system including anterior horn cells.

  11. Identification of novel mutations in the SLC25A15 gene in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome: a clinical, molecular, and functional study.

    Science.gov (United States)

    Tessa, Alessandra; Fiermonte, Giuseppe; Dionisi-Vici, Carlo; Paradies, Eleonora; Baumgartner, Matthias R; Chien, Yin-Hsiu; Loguercio, Carmela; de Baulny, Helene Ogier; Nassogne, Marie-Cecile; Schiff, Manuel; Deodato, Federica; Parenti, Giancarlo; Rutledge, S Lane; Vilaseca, M Antonia; Melone, Mariarosa A B; Scarano, Gioacchino; Aldamiz-Echevarría, Luiz; Besley, Guy; Walter, John; Martinez-Hernandez, Eugenia; Hernandez, Jose M; Pierri, Ciro L; Palmieri, Ferdinando; Santorelli, Filippo M

    2009-05-01

    Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is an autosomal recessive disorder of the urea cycle. With the exception of the French-Canadian founder effect, no common mutation has been detected in other populations. In this study, we collected 16 additional HHH cases and expanded the spectrum of SLC25A15/ORC1 mutations. Eleven novel mutations were identified including six new missense and one microrearrangement. We also measured the transport properties of the recombinant purified proteins in reconstituted liposomes for four new and two previously reported missense mutations and proved that the transport activities of these mutant forms of ORC1 were reduced as compared with the wild-type protein; residual activity ranged between 4% and 19%. Furthermore, we designed three-dimensional (3D)-modeling of mutant ORC1 proteins. While modeling the changes in silico allowed us to obtain new information on the pathomechanisms underlying HHH syndrome, we found no clear-cut genotype-phenotype correlations. Although patient metabolic alterations responded well to low-protein therapy, predictions concerning the long-term evolution of HHH syndrome remain uncertain. The preference for a hepatic rather than a neurological presentation at onset also continues, largely, to elude us. Neither modifications in oxidative metabolism-related energy, such as those expected in different mtDNA haplogroups, nor sequence variants in SLC25A2/ORC2 seem to be crucial. Other factors, including protein stability and function, and ORC1-ORC2 structural interactions should be further investigated.

  12. The human and mouse SLC25A29 mitochondrial transporters rescue the deficient ornithine metabolism in fibroblasts of patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome.

    Science.gov (United States)

    Camacho, José A; Rioseco-Camacho, Natalia

    2009-07-01

    The hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is a disorder of the urea cycle (UCD) and ornithine degradation pathway caused by mutations in the mitochondrial ornithine transporter (ORNT1). Unlike other UCDs, HHH syndrome is characterized by a less severe and variable phenotype that we believe may, in part, be due to genes with redundant function to ORNT1, such as the previously characterized ORNT2 gene. We reasoned that SLC25A29, a member of the same subfamily of mitochondrial carrier proteins as ORNT1 and ORNT2, might also have overlapping function with ORNT1. Here, we report that both the human and mouse SLC25A29, previously identified as mitochondrial carnitine/acyl-carnitine transporter-like, when overexpressed transiently also rescues the impaired ornithine transport in cultured HHH fibroblasts. Moreover, we observed that, in the mouse, the Slc25a29 message is more significantly expressed in the CNS and cultured astrocytes when compared with the liver and kidney. These results suggest a potential physiologic role for the SLC25A29 transporter in the oxidation of fatty acids, ornithine degradation pathway, and possibly the urea cycle. Our results show that SLC25A29 is the third human mitochondrial ornithine transporter, designated as ORNT3, which may contribute to the milder and variable phenotype seen in patients with HHH syndrome.

  13. Joint CARE-ELAN, CARE-HHH-APD, and EUROTEV-WP3 Workshop on Electron Cloud Clearing

    CERN Document Server

    Scandale, Walter; Schulte, D; Zimmermann, F; Electron Cloud Effects and Technological Consequences; ECL2

    2007-01-01

    This report contains the Proceedings of the joint CARE-HHH-APD, CARE-ELAN, and EUROTEV-WP3 Mini-Workshop on 'Electron Cloud Clearing - Electron Cloud and Technical Consequences', "ECL2", held at CERN in Geneva, Switzerland, 1-2 March 2007). The ECL2 workshop explored novel technological remedies against electron-cloud formation in an accelerator beam pipe. A primary motivation for the workshop was the expected harmful electron-cloud effects in the upgraded LHC injectors and in future linear colliders, as well as recent beam observations in operating facilities like ANKA, CESR, KEKB, RHIC, and SPS. The solutions discussed at ECL2 included enamel-based clearing electrodes, slotted vacuum chambers, NEG coating, and grooves. Several of the proposed cures were assessed in terms of their clearing efficiency and the associated beam impedance. The workshop also reviewed new simulation tools like the 3D electron-ion build-up 'Faktor', modeling assumptions, analytical calculations, beam experiments, and laboratory meas...

  14. Summary of the Mini BNL/LARP/CARE-HHH Workshop on Crab Cavities for the LHC (LHC-CC08)

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Zvi,I.; Calaga, R.; Zimmermann, F.

    2008-05-01

    The first mini-workshop on crab compensation for the LHC luminosity upgrade (LHC-CC08) was held February 24-25, 2008 at the Brookhaven National Laboratory. A total of 35 participants from 3 continents and 15 institutions from around the world participated to discuss the exciting prospect of a crab scheme for the LHC. If realized it will be the first demonstration in hadron colliders. The workshop is organized by joint collaboration of BNL, US-LARP and CARE-HHH. The enormous interest in the subject of crab cavities for the international linear collider and future light sources has resulted in a large international collaboration to exchange aspects of synergy and expertise. A central repository for this exchange of information documenting the latest design effort for LHC crab cavities is consolidated in a wiki page: https://twiki.cern.ch/twiki/bin/view/Main/LHCCrabCavities. The main goal of this workshop was to define a road-map for a prototype crab cavity to be installed in the LHC and to discuss the associated R&D and beam dynamics challenges. The diverse subject of implementing the crab scheme resulted in a scientific program with a wide range of subtopics which were divided into 8 sessions. Each session was given a list of fundamental questions to be addressed and used as a guideline to steer the discussions.

  15. CARE-HHH-APD Workshop on Finalizing the Roadmap for the Upgrade of the CERN and GSI Accelerator Complex

    CERN Document Server

    Zimmermann, Frank; BEAM'07; BEAM 2007; Finalizing the Roadmap for the Upgrade of the LHC and GSI Accelerator Complex

    2008-01-01

    This report contains the Proceedings of the CARE-HHH-APD Event BEAM’07, “Finalizing the Roadmap for the Upgrade of the CERN & GSI Accelerator Complex,” which was held at CERN in Geneva, Switzerland, from 1 to 5 October 2007. BEAM’07 was primarily devoted to beam dynamics limitations for the two, or three, alternative baseline scenarios of the LHC luminosity upgrade and to critical design choices for the upgrade of the LHC injector complex at CERN and for the FAIR complex at GSI. It comprised five parts: (1) a Mini-Workshop on LHC+ Beam Performance, (2) a CERN-GSI Meeting on Collective Effects, (3) the Francesco Ruggiero Memorial Symposium, (4) a Mini-Workshop on the LHC Injectors Upgrade, and (5) the BEAM’07 Summaries. Topics addressed in the first mini-workshop of BEAM’07 ranged from the luminosity performance reach of the upgraded LHC in different scenarios, over the generation and stability of the future LHC beams, the turnaround time, beam–beam effects, luminosity levelling methods, and ...

  16. CARE-HHH-APD Workshop on Interaction Regions for the LHC Upgrade, DAFNE, and SuperB

    CERN Document Server

    Zimmermann, Frank; IR'07; IR 2007

    2008-01-01

    This report contains the Proceedings of the CARE-HHH-APD Mini-Workshop “IR’07,” which was held in Frascati, Italy, from 7 to 9 November 2007. The central theme of the IR’07 Mini-Workshop was the upgrade of the LHC interaction region (IR). A second topic was the experience with the upgraded DAFNE IR as well as the ongoing plans and studies for SuperB, plus possible applications of crab-waist collisions for the LHC upgrade. Discussions during the workshop addressed the performance and limitations of the IR-upgrade optics performance, the optimization of new LHC triplet magnets, the US-LARP magnet strategy (response to Lucio Rossi’s “challenge”), heat deposition, earlyseparation dipoles, detector-integrated quadrupoles, strategy for crab cavities, beam–beam wire compensators, and crab-waist collisions. At IR’07 all auxiliary systems, e.g. wires and crab cavities, received a strong boost. Energy deposition was shown to add an important criterion to the optics requirements—in a first attempt a ...

  17. Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH)-syndrome. Ultrastructural changes of mitochondria in cultured dermal fibroblasts of three patients.

    Science.gov (United States)

    Haust, M D; Dewar, R A; Gatfield, D P; Gordon, B A

    1996-03-01

    Mitochondria of fibroblasts cultured from the skin obtained at biopsy from three patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH)-syndrome, one of the autosomal recessive, heritable urea cycle disorders, were studied with appropriate controls ultrastructurally. The patients were two severely retarded 10- and 12-year-old boys, and a 22-year-old sister of the former whose mental status was at the low normal range; she never had motor impairments or seizures. The mitochondria, similar in all three patients, were increased in number, very long, branching and/or "looping," and tortuous. "Spurs" or "buddings" extended from their lateral surfaces and the terminal segments were often bulbous. Other unusual configurations were also present. In addition, giant forms with large diameter contained innumerable closely-packed and parallel cristae which traversed the entire width of these mitochondria; at times they assumed a "whirled" pattern. The mitochondrial matrix was usually of high electron density. These changes were not a feature of fibroblastic mitochondria of controls. Several changes resembled those of hepatic mitochondria in this disorder. All features are interpreted as an attempt at expanding the mitochondrial volume (via structural substratum) to compensate for the metabolic incompetence of these organelles (a block in transmembranous transfer of ornithine from hyaloplasm into mitochondria for conversion to citrulline).

  18. Long-term monitoring of sleep apnea at home in heart failure patients: preliminary results from the HHH study.

    Science.gov (United States)

    Pinna, G D; Maestri, R; Gobbi, E; Capomolla, S; Campana, C; Emdin, M; Di Lenarda, A; La Rovere, M T; Andrews, D; Johnson, P; Mortara, A; Sleight, P

    2004-01-01

    Sleep apnea is very common in patients with chronic heart failure (CHF) and has important implications in terms of morbidity, mortality and clinical management. Home respiratory telemonitoring might constitute a potential low-cost, widely-applicable alternative to traditional polysomnography in the evaluation and long-term monitoring of breathing disorders in these patients. In this paper we briefly describe the technological infrastructure and present preliminary results of the European Community multicountry trial HHH (Home or Hospital in Heart Failure), which is currently testing a novel system for home telemonitoring of cardiorespiratory signals in CHF patients. The recording and transmitting devices are suitable to be self-managed by the patient. We give a detailed report on the prevalence of nocturnal respiratory disorders at the beginning of the one-year follow-up and on their persistency over the following recordings (one per month). These preliminary findings clearly indicate that intermittent home telemonitoring of respiratory signals based on patient's self-management is feasible in CHF patients and the compliance is high. Reported statistics unambiguously confirm the high prevalence of nocturnal breathing disorders in these patients and clearly show that this phenomenon tends to persist over time.

  19. Epitaxial growth of magnetoresistive (00h), (0hh), and (hhh) La2/3Sr1/3MnO3 thin films on (001)Si substrates

    Science.gov (United States)

    Fontcuberta, J.; Bibes, M.; Martínez, B.; Trtik, V.; Ferrater, C.; Sánchez, F.; Varela, M.

    1999-03-01

    We show that suitable choice of the buffer heterostructure allows us to obtain epitaxial (00h), (0hh), and (hhh) La2/3Sr1/3MnO3 thin films on buffered Si(001) substrates. The magnetotransport properties are investigated. Irrespective of the film texture, it is found that the easy-magnetization direction lies within the film plane. The low-field magnetoresistance is mainly controlled by the in-plane misorientation of crystallites while differences associated with the distinct microstructure of the interfaces appear to have only a second-order effect.

  20. Ornithine and Homocitrulline Impair Mitochondrial Function, Decrease Antioxidant Defenses and Induce Cell Death in Menadione-Stressed Rat Cortical Astrocytes: Potential Mechanisms of Neurological Dysfunction in HHH Syndrome.

    Science.gov (United States)

    Zanatta, Ângela; Rodrigues, Marília Danyelle Nunes; Amaral, Alexandre Umpierrez; Souza, Débora Guerini; Quincozes-Santos, André; Wajner, Moacir

    2016-09-01

    Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is caused by deficiency of ornithine translocase leading to predominant tissue accumulation and high urinary excretion of ornithine (Orn), homocitrulline (Hcit) and ammonia. Although affected patients commonly present neurological dysfunction manifested by cognitive deficit, spastic paraplegia, pyramidal and extrapyramidal signs, stroke-like episodes, hypotonia and ataxia, its pathogenesis is still poorly known. Although astrocytes are necessary for neuronal protection. Therefore, in the present study we investigated the effects of Orn and Hcit on cell viability (propidium iodide incorporation), mitochondrial function (thiazolyl blue tetrazolium bromide-MTT-reduction and mitochondrial membrane potential-ΔΨm), antioxidant defenses (GSH) and pro-inflammatory response (NFkB, IL-1β, IL-6 and TNF-α) in unstimulated and menadione-stressed cortical astrocytes that were previously shown to be susceptible to damage by neurotoxins. We first observed that Orn decreased MTT reduction, whereas both amino acids decreased GSH levels, without altering cell viability and the pro-inflammatory factors in unstimulated astrocytes. Furthermore, Orn and Hcit decreased cell viability and ΔΨm in menadione-treated astrocytes. The present data indicate that the major compounds accumulating in HHH syndrome impair mitochondrial function and reduce cell viability and the antioxidant defenses in cultured astrocytes especially when stressed by menadione. It is presumed that these mechanisms may be involved in the neuropathology of this disease.

  1. Clinical trials update from the joint European Society and World Congress of Cardiology meeting: PEP-CHF, ACCLAIM and the HHH study.

    Science.gov (United States)

    Cleland, John G F; Coletta, Alison P; Clark, Andrew L

    2006-10-01

    This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure, presented at the joint European Society and World Congress of Cardiology meeting held in Barcelona in September 2006. All reports should be considered as preliminary data, as analyses may change in the final publication. The PEP-CHF study suggests that perindopril improves symptoms and functional capacity and may reduce heart failure hospitalisations in patients with diastolic heart failure. Although immune modulation therapy failed to reduce the incidence of all-cause mortality and cardiovascular hospitalisations in the ACCLAIM study, the observed differences in outcome in some heart failure patients warrants further investigation. The HHH study failed to show a beneficial effect of telemonitoring over usual care in patients with heart failure but potentially important country interactions were observed.

  2. Ornithine In Vivo Administration Disrupts Redox Homeostasis and Decreases Synaptic Na(+), K (+)-ATPase Activity in Cerebellum of Adolescent Rats: Implications for the Pathogenesis of Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) Syndrome.

    Science.gov (United States)

    Zanatta, Ângela; Viegas, Carolina Maso; Hickmann, Fernanda Hermes; de Oliveira Monteiro, Wagner; Sitta, Angela; de Moura Coelho, Daniela; Vargas, Carmen Regla; Leipnitz, Guilhian; Wajner, Moacir

    2015-08-01

    Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is an inborn error of metabolism caused by a defect in the transport of ornithine (Orn) into mitochondrial matrix leading to accumulation of Orn, homocitrulline (Hcit), and ammonia. Affected patients present a variable clinical symptomatology, frequently associated with cerebellar symptoms whose pathogenesis is poorly known. Although in vitro studies reported induction of oxidative stress by the metabolites accumulating in HHH syndrome, so far no report evaluated the in vivo effects of these compounds on redox homeostasis in cerebellum. Therefore, the present work was carried out to investigate the in vivo effects of intracerebellar administration of Orn and Hcit on antioxidant defenses (reduced glutathione concentrations and the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase), lipid oxidation (malondialdehyde concentrations), as well as on the activity of synaptic Na(+), K(+)-ATPase, an enzyme highly vulnerable to free radical attack, in the cerebellum of adolescent rats. Orn significantly increased malondialdehyde levels and the activities of all antioxidant enzymes, and reduced Na(+), K(+)-ATPase activity. In contrast, glutathione concentrations were not changed by Orn treatment. Furthermore, intracerebellar administration of Hcit was not able to alter any of these parameters. The present data show for the first time that Orn provokes in vivo lipid oxidative damage, activation of the enzymatic antioxidant defense system, and reduction of the activity of a crucial enzyme involved in neurotransmission. It is presumed that these pathomechanisms may contribute at least partly to explain the neuropathology of cerebellum abnormalities and the ataxia observed in patients with HHH syndrome.

  3. Prenatal exclusion of the HHH syndrome.

    Science.gov (United States)

    Gray, R G; Green, A; Hall, S; McKeown, C

    1995-05-01

    Prenatal diagnosis of the hyperornithinaemia, hyperammonaemia, and homocitrullinuria syndrome is described by the analysis of ornithine incorporation in second-trimester cultured amniotic fluid cells. An unaffected fetus was predicted and confirmed in the newborn child. This is the third reported prenatal diagnosis for this disorder and the second predicting an unaffected fetus.

  4. Evidence of CP violation in B -> hhh charmless decays

    CERN Document Server

    CERN. Geneva

    2012-01-01

    We present the first evidence of CP violation in the B+→ pi+pi-pi+,  B+→ K+pi+pi-, B+→ K+K-pi+ and B+→K+K-K+ decays using the 1.0 fb-1 of data collected by the LHCb experiment during 2011. The results show that the 3pi and Kpipi channels present a positive asymmetry while the KKpi and KKK modes present a negative asymmetry. We also study the variation of the CP violation effects in the phase space of each three-body decay.  We find significant inhomogeneities that reveal regions with particularly large asymmetries in the pipi and KK low mass regions in B+→pi+pi-pi+ and B+→K+K-pi+ respectively.

  5. Fertilizer intensification and its impacts in China's HHH Plains

    Science.gov (United States)

    The accomplishment of China’s food security by application of high rates of fertilizers has generated several controversies regarding the quality of soil and water resources. Thus, the objective of this article is to assess the effects and causes of the fertilizer intensification in the Huang Huai ...

  6. chi_cJ Decays to h^+h^-h^0

    CERN Document Server

    Athar, S; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Wiss, J; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z V; Seth, K K; Tomaradze, A G; Ernst, J; Severini, H; Dytman, S A; Love, W; Savinov, V; Aquines, O; Li, Z; López, A; Mehrabyan, S S; Méndez, H; Ramírez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Brock, I; Chen, J; Ferguson, T; Tatishvili, G T; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M

    2006-01-01

    Using a sample of 3x10^6 psi(2S) decays recorded by the CLEO detector, we study three body decays of the chi_{c0}, chi_{c1}, and chi_{c2} produced in radiative decays of the psi(2S). We consider the decay modes pi+ pi- eta, K+ K- eta, p pbar eta, pi+ pi- etaprime, K+ K- pi0, p pbar pi0, pi+ K- K0S, and K+ pbar Lambda measuring branching fractions or placing upper limits. For chi_{c1} to pi+ pi- eta, K+ K- pi0, and pi+ K- K0S our observed samples are large enough to study the substructure in a Dalitz plot analysis. The results presented in this document are preliminary.

  7. chi_{cJ} Decays to h^+h^-h^0

    CERN Document Server

    Athar, S; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z V; Seth, K K; Tomaradze, A G; Ernst, J; Severini, H; Love, W; Savinov, V; Aquines, O; Li, Z; López, A; Mehrabyan, S S; Méndez, H; Ramírez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Ferguson, T; Tatishvili, G T; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; al, et

    2007-01-01

    Using a sample of 3 million psi(2S) decays recorded by the CLEO detector, we study three-body decays of the chi_c0, chi_c1, and chi_c2 produced in radiative decays of the psi(2S). We consider the final states pi+ pi- eta, K+ K- eta, p p-bar eta, pi+ pi- eta-prime, K+ K- pi0, p p-bar pi0, pi+ K- K0S, and K+ p-bar Lambda, measuring branching fractions or placing upper limits. For chi_c1 decays to pi+ pi- eta, K+ K- pi0, and pi+ K- K0S our observed samples are large enough to study the substructure in a Dalitz plot analysis.

  8. Summy of the working groupI of the care HHH LUMI-2005 workshop

    CERN Document Server

    Brüning, Oliver Sim

    2006-01-01

    The working group I of the LUMI-2005 workshop was asked to put together a catalogue of basic design options for the IR solutions for an LHC-upgrade. The goal of the working group was to discuss the different solutions with respect to the maximum beta-functions inside the first focusing quadrupole magnets and the resulting required quadrupole apertures the chromatic aberrations on the one hand and the implications for the magnet technology on the other hand. Such a comparison requires a wide range of input data ranging from the expected loss patterns at the magnetic elements and the resulting peak and average heat deposition to the obtainable peak magnetic field and quench limits for different magnet design options and the correct ability of the chromatic aberrations for a given optics design. Given the wide spectrum of relevant input data the working group could not yet prepare a final ranking of the various design options. Rather the working group succeeded in fixing some of the key boundary conditions in or...

  9. 40 CFR Table 3 to Subpart Hhh of... - Operating Parameters To Be Monitored and Minimum Measurement and Recording Frequencies

    Science.gov (United States)

    2010-07-01

    ... mercury (Hg) sorbent flow rate Hourly Once per hour ✔ ✔ Minimum pressure drop across the wet scrubber or... rural HMIWI HMIWI a with dry scrubber followed by fabric filter HMIWI a with wet scrubber HMIWI a with dry scrubber followed by fabric filter and wet scrubber Maximum operating parameters: Maximum...

  10. 黄淮海平原土地生态服务功能浅析%Analysis on Land Ecosystem Services of HHH Plain in China

    Institute of Scientific and Technical Information of China (English)

    杨君; 郝晋珉; 白玮; 余宝林; 谢敏

    2006-01-01

    随着人们生活水平的提高和可持续发展研究的深入,对生态环境的保护和研究也逐步得以重视,生态服务功能的探讨也逐渐成为生态经济学研究的一个热点.黄淮海平原水资源短缺问题日益严重,成为土地生态系统健康的主要制约因素之一.水资源短缺也是广大平原地区土地生态服务功能减弱的主要因素,成为全面建设小康社会所要求的生态环境质量的主要制约因素.因此,文章以河北省为例,分析了平原地区生态服务功能低下的原因,并提出相关建议,以期更好地提高我国粮食安全保证率,为可持续发展服务.

  11. A novel mutation in the SLC25A15 gene in a Turkish patient with HHH syndrome: functional analysis of the mutant protein.

    Science.gov (United States)

    Ersoy Tunalı, Nagehan; Marobbio, Carlo M T; Tiryakioğlu, N Ozan; Punzi, Giuseppe; Saygılı, Seha K; Onal, Hasan; Palmieri, Ferdinando

    2014-05-01

    The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome is a rare autosomal recessive disorder caused by the functional deficiency of the mitochondrial ornithine transporter 1 (ORC1). ORC1 is encoded by the SLC25A15 gene and catalyzes the transport of cytosolic ornithine into mitochondria in exchange for citrulline. Although the age of onset and the severity of the symptoms vary widely, the disease usually manifests in early infancy. The typical clinical features include protein intolerance, lethargy, episodic confusion, cerebellar ataxia, seizures and mental retardation. In this study, we identified a novel p.Ala15Val (c.44C>T) mutation by genomic DNA sequencing in a Turkish child presenting severe tantrum, confusion, gait disturbances and loss of speech abilities in addition to hyperornithinemia, hyperammonemia and homocitrullinuria. One hundred Turkish control chromosomes did not possess this variant. The functional effect of the novel mutation was assessed by both complementation of the yeast ORT1 null mutant and transport assays. Our study demonstrates that the A15V mutation dramatically interferes with the transport properties of ORC1 since it was shown to inhibit ornithine transport nearly completely.

  12. Risk factor analysis for bone marrow histiocytic hyperplasia with hemophagocytosis: an autopsy study.

    Science.gov (United States)

    Inai, Kunihiro; Noriki, Sakon; Iwasaki, Hiromichi; Naiki, Hironobu

    2014-07-01

    The excessive release of inflammatory cytokines occasionally induces life-threatening hemophagocytosis referred to as hemophagocytic syndrome (HPS). A similar condition, histiocytic hyperplasia with hemophagocytosis (HHH), is often seen in bone marrow collected during autopsy. Unlike HPS, the pathogenesis of HHH remains unclear. Therefore, we performed a clinicopathological analysis of HHH from 70 autopsy cases at the University of Fukui Hospital. HHH was detected in 29 of 70 autopsies (41.4 %) and was significantly complicated with hematological diseases (p HHH (p HHH patients as compared with non-HHH patients. Concentrations of inflammatory mediators including IL-1β, IL-6, and IL-8 were significantly increased in HHH patients. Multivariate risk factor analysis identified hematological diseases (odds ratio (OR), 11.71), ≥ 15 % BM macrophages (OR, 9.42), sepsis (OR, 7.77), and high serum IL-6 levels (OR, 1.00) as independent risk factors for HHH. HHH with hypocellular BM, the most aggressive form of HHH, was recognized in 8 of 29 HHH patients and was associated with ≥ 25 % BM macrophages (p HHH patients fulfilled the diagnostic criteria of HPS. These findings suggest that HHH is a different entity from HPS and that it preferentially develops under conditions of excessive inflammation and its associated risks, such as hematological diseases and sepsis.

  13. Data of evolutionary structure change: 1CTJA-351CA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available J A 1CTJA EQFLD-GGFNI ...1CTJA-351CA 1CTJ 351C A A EADLALGKAVFDGN-CAACHAGGGNNVIPDHTLQKAAIE...HHHH -- HHHHHHHHHHHH ----- 0 1CT...ure>HHH - Hure> ATOM...Chain> AAKFAGQAGAE ure>HHH HH

  14. 40 CFR 96.281 - General.

    Science.gov (United States)

    2010-07-01

    ....208, and subparts BBB and CCC and subparts FFF through HHH of this part, a CAIR SO2 opt-in unit shall...) Solely for purposes of applying, as provided in this subpart, the requirements of subpart HHH of...

  15. 40 CFR 97.254 - Compliance with CAIR SO2 emissions limitation.

    Science.gov (United States)

    2010-07-01

    ... sulfur dioxide emissions, determined in accordance with subpart HHH of this part, from all CAIR SO2 units... subpart HHH of this part, from all CAIR SO2 units at the source for the control period; or (ii) If...

  16. 40 CFR 96.254 - Compliance with CAIR SO2 emissions limitation.

    Science.gov (United States)

    2010-07-01

    ... sulfur dioxide emissions, determined in accordance with subpart HHH of this part, from all CAIR SO2 units... subpart HHH of this part, from all CAIR SO2 units at the source for the control period; or (ii) If...

  17. 77 FR 47631 - Agency Information Collection Activities: Request for Comments on Twenty-Four Proposed...

    Science.gov (United States)

    2012-08-09

    ...: NSPS for Synthetic Fiber Production Facilities (40 CFR Part 60, Subpart HHH). ICR Numbers: EPA ICR..., 2012. (9) NSPS for Synthetic Fiber Production Facilities (40 CFR Part 60, Subpart HHH); Learia Williams... Part 60, Subpart HHH); Docket ID Number EPA-HQ-OECA-2012-0528; EPA ICR Number 1156.12; OMB...

  18. 40 CFR 96.284 - Opt-in process.

    Science.gov (United States)

    2010-07-01

    ... accordance with subpart HHH of this part. A determination of sufficiency shall not be construed as acceptance... unit and all other applicable parameters, in accordance with subpart HHH of this part, starting on the date of certification of the appropriate monitoring systems under subpart HHH of this part...

  19. 40 CFR 96.206 - Standard requirements.

    Science.gov (United States)

    2010-07-01

    ... requirements of subpart HHH of this part. (2) The emissions measurements recorded and reported in accordance with subpart HHH of this part shall be used to determine compliance by each CAIR SO2 source with the... HHH of this part. (2) A CAIR SO2 unit shall be subject to the requirements under paragraph (c)(1)...

  20. 40 CFR 97.284 - Opt-in process.

    Science.gov (United States)

    2010-07-01

    ... monitored and reported in accordance with subpart HHH of this part. A determination of sufficiency shall not... rate and the heat input of the unit and all other applicable parameters, in accordance with subpart HHH... subpart HHH of this part and continuing until a CAIR opt-in permit is denied under § 97.284(f) or, if...

  1. 黄淮海平原地下水危机下的耕地资源可持续利用%Cropland Sustainable Use Impacted by Groundwater Depletion in China's HHH Plains

    Institute of Scientific and Technical Information of China (English)

    张雪靓; 孔祥斌

    2014-01-01

    研究目的:基于多数据源计算黄淮海平原地下水位平均下降速度,揭示该地区地下水快速下降机理,提出水资源限制下的耕地可持续利用对策.研究方法:根据收集的黄淮海平原266个地下水位下降速度样本点和5个典型城市地下水位长期监测点,由克里格插值得到区域地下水位平均下降速度,并采用空间分析的方法叠加2012年耕地分布图,分析不同地下水下降速度在9个子生态区对应的耕地分布情况.研究结果:1980年以来,黄淮海平原地下水以浅层0.46±0.37m/年,深层1.14±0.58 m/年的速度下降,成为世界上面积最大的地下水漏斗区.造成地下水快速下降的主要原因是区域粮食增产和一年两熟种植制度下小麦播种面积的增加导致的大面积、高强度的井灌方式.根据地下水资源危机程度,将黄淮海平原划分为休养调整区、强度降低区、生态保护区和潜力提升区4个耕地利用调整区划.研究结论:黄淮海平原高集约高投入的耕地利用方式不可持续,在区域地下水危机的情况下,应降低超采区的耕地利用强度,同时提升潜力区的耕地生产潜力,实现耕地生产、生态质量协同提升,在保障粮食安全和生态安全的前提下实现耕地资源可持续利用.

  2. 黄淮海区域早熟大白菜品种比较试验与规模化种植管理%Comparison Test on Earliness Chinese Cabbages and Scale Planting Management in the HHH Region

    Institute of Scientific and Technical Information of China (English)

    李菊花

    2007-01-01

    将几个常见的早熟大白菜品种,在黄淮平原常温下生产的抗病性、品质及适应性进行对比实验,用实验结果筛选出产量高、效益好的大白菜品种,向菜农提供规模化、科学化生产管理模式的科学依据,为全区规模化发展高效蔬菜奠定基础.

  3. 1982~2000年黄淮海地区植被覆盖变化特征分析%Analysis on the Vegetation Cover Change in the HHH Zone of China in 1982~2000

    Institute of Scientific and Technical Information of China (English)

    莫瑶; 郑有飞; 陈怀亮; 邹春辉

    2007-01-01

    利用1982~2000年8km NOAA-AVHRR数据,采用均值法、差值法和一元线性回归模拟法,分析了中国黄淮海地区植被的动态变化及其空间分布特征,模拟了年NDVI均值的变化趋势,并对不同植被类型的NDVI年内和年际变化规律进行了分析.结果表明:黄淮海地区植被覆盖总体上呈增加趋势,20世纪90年代末相对80年代初平均NDVI值增加了近0.03.从空间分布上看,大部分地区NDVI都呈增加的趋势,其中NDVI极显著增加的区域主要分布在山东的西北部和西部、河南的东部、河北的北部及江苏的北部地区,F检验的显著性水平达到了99%.NDVI呈减少趋势的地区很少,主要分布在北京、天津、山西中部.各植被类型的NDVI在年内的变化呈很强的季节性,年际变化规律大致相同,呈波动上升的趋势.

  4. HHH堵漏剂在治理多点井漏中的应用%Application of HHH LCM to Lost Circulation Control at Multiple Points in a Well

    Institute of Scientific and Technical Information of China (English)

    肖波; 李晓阳; 陈忠实; 程常修; 刘滨

    2008-01-01

    在异常高压区的深井钻井中,经常遇到以压裂性诱导漏失为主的多漏点井漏,该类型井漏的漏失位置往往难以确定,各漏失点差异性较大,一次性治理成功往往存在复杂的技术难题.针对川渝地区同裸眼多漏点井漏使用HHH堵漏剂一次性全部封堵成功率不高的问题,通过分析多漏点井漏的漏失特性和HHH堵漏剂应用于多漏点堵漏的工艺技术,认为现场堵漏施工工艺的优化对提高多漏点井漏治理成功率十分关键,在施工中优化堵漏浆挤注排量可以实现同裸眼多漏点的一次性堵漏成功.在剑门1井多漏点井漏的堵漏施工实践中,几次作业通过调整优化施工工艺,从正反两方面证实了优化现场工艺能够提高同裸眼多漏点井漏的一次性治理成功率.

  5. Data of evolutionary structure change: 1LCTA-1BP5A [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1LCTA-1BP5A 1LCT 1BP5 A A RSVQWCAVSNPEATKCFQWQRNMRKV---RGPPVSCIKR...> 0 1LCT A 1LCT...A NMRKV---RGPPV ure>H...GPSV ure>HHH ure> ATOM 174 CA HIS A 25...pdbChain> 1BP5A PEPRK--PLEKA ure> -- HHH

  6. Data of evolutionary structure change: 1BJFB-2CT9B [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 9 B 2CT9B TSLDKGENGTLS ...1BJFB-2CT9B 1BJF 2CT9 B B ---NSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCP-...in>1BJFB LRDCP--SGHLS ure>HHH -- EEEE...>LEU CA 338 SER CA 279 2CT...ure>HHH EEure> ATOM 1785 CA THR B 36 25.632 42.23

  7. Data of evolutionary structure change: 1CG8A-2DN1B [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available equence>FSGFE-----ACNEQ ure> ----- HH> B 2DN1B FGDLSTPDAVMGNPK re>G HHHH HH...ence>VNLQA-FTPVT >HH - HHH> 2DN1 B 2DN1B HHFGKEFTPPV ...>HHHGGG HHH> ATOM 1931 CA HIS B 116 17.758 39.

  8. Effect of changes in diet energy density on feed intake, milk yield and metabolic parameters in dairy cows in early lactation

    DEFF Research Database (Denmark)

    Nielsen, N.I.; Friggens, N.C.; Larsen, T.

    2007-01-01

    calving while cows assigned to HHH or NNN were fed the same TMR for all 9 weeks. Results from cows on treatment HNH were compared with group HHH while cows on treatment NHN were compared with group NNN. When the diet changed from N to H and H to N, cows increased and decreased their dry-matter intake (DMI...

  9. 40 CFR 97.281 - General.

    Science.gov (United States)

    2010-07-01

    ... CCC and subparts FFF through HHH of this part, a CAIR SO2 opt-in unit shall be treated as a CAIR SO2... applying, as provided in this subpart, the requirements of subpart HHH of this part to a unit for which...

  10. 40 CFR 97.206 - Standard requirements.

    Science.gov (United States)

    2010-07-01

    ... subpart HHH of this part. (2) The emissions measurements recorded and reported in accordance with subpart HHH of this part shall be used to determine compliance by each CAIR SO2 source with the CAIR SO2... the control period from all CAIR SO2 units at the source, as determined in accordance with subpart...

  11. Measuring Trilinear Higgs Coupling in $WHH$ and $ZHH$ Productions at the HL-LHC

    CERN Document Server

    Cao, Qing-Hong; Yan, Bin

    2015-01-01

    Determination of trilinear Higgs coupling ($\\lambda_{HHH}=\\kappa\\lambda_{HHH}^{\\rm SM}$) through Higgs pair productions is a major motivation for the LHC high luminosity phase. We perform a detailed collider simulation to explore the potential of measuring $\\lambda_{HHH}$ in the $VHH$ ($V=W,Z$) production at the HL-LHC. We find that the trilinear Higgs coupling in the SM ($\\lambda_{HHH}^{\\rm SM}$) could be measured at the level of $1.3\\sigma$. Combining with the gluon fusion, vector boson fusion and $t\\bar{t}HH$ channels, $\\lambda_{HHH}^{\\rm SM}$ is expected to be measured at the level of $3.13\\sigma$. If no evidence of Higgs pair productions were observed, the $VHH$ production, together with the gluon fusion channel, would impose a bound of $0.5\\leq \\kappa \\leq 2.2$ at the 95\\% confidence level.

  12. 温度植被干旱指数法(TVDI)在黄淮海平原土壤湿度反演中的应用研究%Application of Temperature-Vegetation Dryness Index (TVDI) in Estimation of Soil Moisture in the HHH Plain

    Institute of Scientific and Technical Information of China (English)

    王纯枝; 毛留喜; 何延波; 韩丽娟; 陈健; 宇振荣

    2009-01-01

    植被指数和地表温度是描述地表特征的两个重要参数,基于遥感植被指数和地表温度信息进行区域地表水分状况等陆表变化过程研究,是目前遥感和陆表过程研究中的前沿方向.利用MODIS数据产品MOD13A2和MOD11A2获取的归-化植被指数(NDVI)和地表温度(Ts),构建Ts-NDVI特征空间,依据该特征空间计算的温度植被干旱指数(TVDI)作为土壤湿度监测指标,反演了黄淮海平原2004年冬小麦4~5月份和夏玉米7~10月份每16 d的土壤湿度,并经相应的土壤湿度数据验证.结果表明:TVDI与土壤湿度显著相关(α=0.05),且反演的黄淮海平原土壤湿度的时空分布特征与农作物生育期规律、生长季总降雨量分布规律基本吻合;特别是0~10 cm、10~20 cm、20~40 cm三个土层中,TVDI更能稳定反映和指示地表10~20 cm土壤水分状况,因而TVDI方法适用于黄淮海平原作物生长季的土壤湿度动态监测.

  13. Dicty_cDB: AFH258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 6. 2 Translated Amino Acid sequence gllxskinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkilmilk...vrqfqs*wvlinckl*iqsmvgfhqrcnkqimilkscllvf ywvplmhl*fgkvqerpq*fvdslkihfgvnkiisssirhqaqvmnisplsil*nlvipm vqyws...*nkkkl* Frame B: gllxskinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkilmilkq* hhh*SQNPLVAVLVKINHHHHHHVVVVVIK

  14. Data of evolutionary structure change: 1BVUE-1HRDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1BVUE-1HRDA 1BVU 1HRD E A QDPFEIAVKQLE---------------RAAQYMDISEEA...EVITKKNADNI---KAKIVAELANGPTTPEADEILYEKG-ILIIPDFLCNAGGVTVSYFEWVQNITGDYWTVEETRAKLDKKMTKAFWDVYNTHKEKNIN--MRDAAY...1BVUE EKNIN--MRDAA H --HHHHH 1HRD A 1HRDA... 1HRDA RKIVG--GFYNG HHH --

  15. 75 FR 19409 - Request for Comment on Minimum Requirements for Criteria in Fiscal Year 2011 Grant Applications...

    Science.gov (United States)

    2010-04-14

    ... health records is dynamic. The Administrator understands that there are several initiatives being... addressed can be viewed by searching ``HHH-OS-2009-0006'' at the http://www.regulations.gov website....

  16. Dicty_cDB: AFH252 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available i*kilaiilkkllfnhqkkqlql*ynkilmilkq*hhh* sqnplvavlvkinhhhhhhvvvvviklkknknqvvvvvvkvnhhhhvvvviiinlkknkn qvvveem...ikrvlk le*kllkiryw*chqrvvlvnqqfhpcyhmvfqreiitppkyly*mlifavrqfqs*wvl inckl*iqsmvgfhqrcnkqimilk...CSSCPGQNACKSQADNPDKKSIEI RMKVIKNKILVMSSKGGVGKSTVSSLLSYGFSKRNNNTTKVSVLDVDICGPSIPKLMGVD KLQIINSEYGWIPPKVQQANHDIKVMSV--- ---rcnkqimilk...IPPKVQQANHDIKVMSV--- ---KVQQANHDIKVMSVGFLLGTPDAPVIWKGPRKTTMIRRFLKDTFWGKQDYLIIDTPP GTSDEHLSIINSLKSCNPDGAVLVTT...hhqsicirc*ylrsvnskangc* *ianykfrvwldstkgatsks*y*shvc--- ---KVQQANHDIKVMSVGFLLGTPDAPVIWKGPRKTTMIR

  17. Dicty_cDB: VFL193 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available e B: gllekhlkkskkinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkil milkq*hhh*sqnplvavlvkinhhhhhhvvvvviklkknkn...***s*rktkirllwr**kkwiiiml*irind nnnnnk*tnkr*fkyfikw--- ---qfqs*wvlinckl*iqsmvgfhqrcnkqimilkscllvfywvplmhl*fg...MGVDKLQIINSEYGWIPPKVQQANHDIKVMSVGFLLGTPDAPVIWKGPRKTT MIRRFLKDTFWGKQDYLIIDTPPGTSDEHLSIINSLKSCNPDGAVLVTTPQDLSC...PKLMGVDKLQIINSEYGWIPPKVQQANHDIKVMSVGFLLGTPDAPVIWKGPRKTT MIRRFLKDTFWGKQDYLIIDTPPGT

  18. Density dependence of clutch size: habitat heterogeneity or individual adjustment?

    NARCIS (Netherlands)

    Both, C.

    1998-01-01

    1. Two hypotheses have been proposed to explain density- dependent patterns in reproduction. The habitat heterogeneity hypothesis (HHH) explains density-dependent reproduction at the population level from poorer quality territories in heterogeneous environments only being occupied at high densities.

  19. Data of evolutionary structure change: 1LFQA-1RQAB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1LFQA-1RQAB 1LFQ 1RQA A B -VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPT...HCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH - HHHHHHHHHH...ex>0 1RQA B 1RQAB A 1LFQA WGKVGAHAGEYG HHH

  20. Genetics Home Reference: ornithine translocase deficiency

    Science.gov (United States)

    ... Diagnosis of Japanese patients with HHH syndrome by molecular genetic analysis: a common mutation, R179X. J Hum Genet. ... Accessibility FOIA Viewers & Players U.S. Department of Health & Human Services National Institutes of Health National Library of ...

  1. Data of evolutionary structure change: 1BINA-2OIFE [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1BINA-2OIFE 1BIN 2OIF A E VAFTEKQDALVSSSFEAFKANIPQYSVVFYTSILEKAPA...KKA--- VVFSEEKEALVLKSWAIMKKDSANLGLRFFLKIFEIAPSARQMFPFLRDSDVPLETNPKLKTHAVSVFVMTCEAAAQLRKAGKITVRE...in>E 2OIFE PFLRDSDVPLET HH.../entryChain> 2OIF E 2OIFE 2OIFE ALPADMWGPEM H HHH

  2. Deconstructing the mammal species richness pattern in Europe - towards and understanding of the relative importance of climate, biogeographic history, habitat heterogeneity and humans

    DEFF Research Database (Denmark)

    Fløjgaard, Camilla; Normand, Signe; Skov, Flemming;

    2011-01-01

    Aim  We deconstructed the mammal species richness pattern in Europe to assess the importance of large-scale gradients in current macroclimate relative to biogeographic history, habitat heterogeneity and human influence (HHH variables) as richness determinants for total species, and for widespread...... partitioning to assess the importance of macroclimate and HHH variables. The HHH variables included two historical factors, estimated by novel methodologies: (1) ice-age-driven dynamics, represented by accessibility to recolonization from hindcasting-estimated glacial refugia, and (2) biogeographic peninsular...... dynamics, represented by distance to the entry region for the main European faunal source in western Asia. Results  A large fraction of explained variation was shared between macroclimate and HHH in the SAR models. For total species richness, more variation could be uniquely attributed to macroclimate than...

  3. 40 CFR 147.151 - EPA-administered program.

    Science.gov (United States)

    2010-07-01

    ... requirements contained in subpart HHH of this part. The program for all injection activity except that on Navajo Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  4. 77 FR 58537 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Science.gov (United States)

    2012-09-21

    ... according to the procedures prescribed in 5 CFR 1320.12. On May 9, 2011 (76 FR 26900) EPA sought comments on.../Infectious Waste Incinerators, (40 CFR part 60, subpart Ce, and 40 CFR part 62, subpart HHH). Owners...

  5. 42 CFR Appendix to Subpart B of... - Required Consent Form

    Science.gov (United States)

    2010-10-01

    ... CFR part 50, subpart B, relating to the sterilization of persons in federally assisted public health... Clearance Officer, ASBTF/Budget Room 503 HHH Building, 200 Independence Avenue, SW., Washington, DC...

  6. 77 FR 70751 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Science.gov (United States)

    2012-11-27

    ... prescribed in 5 CFR 1320.12. On August 9, 2012 (77 FR 47631), EPA sought comments on this ICR pursuant to 5... the Provisions specified at 40 CFR part 60, subpart HHH. Owners or operators of the...

  7. 40 CFR 147.2253 - EPA-administered program-Indian lands.

    Science.gov (United States)

    2010-07-01

    ... Mountain Ute consists of the requirements set forth at subpart HHH of this part. The program for all other wells on Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148,...

  8. Data of evolutionary structure change: 3DLSB-3DLSF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 3DLSB-3DLSF 3DLS 3DLS B F AVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE...KNKEVVVKFIKKE--WIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDE...NKEVVVKFIKKEKVWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDEN...HHH GGG HHHH - 0 3DLS B 3DLSB FIKKE--WIEDP

  9. Data of evolutionary structure change: 1D5NA-1UNFX [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 830719470977783 EVID>EVID> 1 1UNF A X ----SYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYV...NNANAALESL----PEFANLPVEELITKLDQLPADKKTVL---------RNNAGGHANHSLFWKGLKKGTT--LQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGW...HHH EVID> 0 TRP CA 375 1UNF X 1UNF

  10. The Magic Background of Pearl Harbor. Volume 5

    Science.gov (United States)

    1978-01-01

    British Imperial Bank III, 381 Brooke, Alan , British General IV, 383 Brooke-Popham, Sir Robert, British Commander in the Far East 11,288 III, 429 Brooks...h h _n- 11,96 President Taylor, U.S. ship h__n_h_hhh_n-hhh__h_hhnhhh_nhh III, 136, 193,217 Prieto , Indalecion, Spanish ex-Minister, head of Aid to

  11. Methanopyrus kandleri topoisomerase V contains three distinct AP lyase active sites in addition to the topoisomerase active site.

    Science.gov (United States)

    Rajan, Rakhi; Osterman, Amy; Mondragón, Alfonso

    2016-04-20

    Topoisomerase V (Topo-V) is the only topoisomerase with both topoisomerase and DNA repair activities. The topoisomerase activity is conferred by a small alpha-helical domain, whereas the AP lyase activity is found in a region formed by 12 tandem helix-hairpin-helix ((HhH)2) domains. Although it was known that Topo-V has multiple repair sites, only one had been mapped. Here, we show that Topo-V has three AP lyase sites. The atomic structure and Small Angle X-ray Scattering studies of a 97 kDa fragment spanning the topoisomerase and 10 (HhH)2 domains reveal that the (HhH)2 domains extend away from the topoisomerase domain. A combination of biochemical and structural observations allow the mapping of the second repair site to the junction of the 9th and 10th (HhH)2 domains. The second site is structurally similar to the first one and to the sites found in other AP lyases. The 3rd AP lyase site is located in the 12th (HhH)2 domain. The results show that Topo-V is an unusual protein: it is the only known protein with more than one (HhH)2 domain, the only known topoisomerase with dual activities and is also unique by having three AP lyase repair sites in the same polypeptide.

  12. The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition.

    Science.gov (United States)

    Wienk, Hans; Slootweg, Jack C; Speerstra, Sietske; Kaptein, Robert; Boelens, Rolf; Folkers, Gert E

    2013-07-01

    To maintain the integrity of the genome, multiple DNA repair systems exist to repair damaged DNA. Recognition of altered DNA, including bulky adducts, pyrimidine dimers and interstrand crosslinks (ICL), partially depends on proteins containing helix-hairpin-helix (HhH) domains. To understand how ICL is specifically recognized by the Fanconi anemia proteins FANCM and FAAP24, we determined the structure of the HhH domain of FAAP24. Although it resembles other HhH domains, the FAAP24 domain contains a canonical hairpin motif followed by distorted motif. The HhH domain can bind various DNA substrates; using nuclear magnetic resonance titration experiments, we demonstrate that the canonical HhH motif is required for double-stranded DNA (dsDNA) binding, whereas the unstructured N-terminus can interact with single-stranded DNA. Both DNA binding surfaces are used for binding to ICL-like single/double-strand junction-containing DNA substrates. A structural model for FAAP24 bound to dsDNA has been made based on homology with the translesion polymerase iota. Site-directed mutagenesis, sequence conservation and charge distribution support the dsDNA-binding model. Analogous to other HhH domain-containing proteins, we suggest that multiple FAAP24 regions together contribute to binding to single/double-strand junction, which could contribute to specificity in ICL DNA recognition.

  13. Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome with stroke-like imaging presentation: clinical, biochemical and molecular analysis.

    Science.gov (United States)

    Al-Hassnan, Zuhair N; Rashed, Mohamed S; Al-Dirbashi, Osama Y; Patay, Zoltan; Rahbeeni, Zuhair; Abu-Amero, Khaled K

    2008-01-15

    Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is an autosomal recessive disorder caused by mutations in ORNT1 gene that encodes a mitochondrial ornithine transporter. It has variable clinical presentations with episodic hyperammonemia, liver dysfunction, and chronic neurological manifestations. In this work, we report the findings of HHH syndrome in 3 Saudi siblings. The 4-year-old proband presented with recurrent Reye-like episodes, hypotonia, and multiple stroke-like lesions on brain MRI. Biochemical and molecular analysis confirmed that she had HHH syndrome. She significantly improved on protein restriction and sodium benzoate. Her two older siblings have milder phenotypes with protein intolerance and learning problems. In comparison to their sister, their homocitrulline and orotic acid were only mildly elevated even before treatment. The three patients were homozygous for a novel mutation in ORNT1 with a Gly220Arg change. In view of the CNS lesions, which initially were felt to be suggestive of MELAS, we sequenced the entire mtDNA genome and no potential pathogenic mutations were detected. Analysis of ORNT2 did not provide explanation of the clinical and biochemical variability. This work presents a yet unreported CNS involvement pattern, notably multiple supratentorial stroke-like lesions in association with HHH syndrome. Moreover, it illustrates considerable clinical/biochemical correlation, and describes a novel mutation. We suggest including HHH syndrome in the differential diagnosis of patients found to have stroke-like lesions on brain MRI.

  14. Projected sensitivity to non-resonant Higgs boson pair production in the $b\\bar{b}b\\bar{b}$ final state using proton–proton collisions at HL-LHC with the ATLAS detector

    CERN Document Server

    The ATLAS collaboration

    2016-01-01

    Estimates of the sensitivity to non-resonant Higgs boson pair production using the $HH\\to b\\bar{b}b\\bar{b}$ channel with the full HL-LHC dataset of 3000 fb$^{-1}$ of proton--proton collisions at $\\sqrt{s} = 14\\,$TeV. These estimates are based on the extrapolation of current results obtained with the 2016 dataset, comprising $\\int Ldt = 10.1\\,$fb$^{-1}$ of proton-proton collisions at $\\sqrt{s} = 13\\,$TeV. In the absence of any signal and without (with) systematics, cross-sections 1.5 times (5.2 times) greater than the Standard Model prediction are excluded at the 95% confidence level. The Higgs boson self-coupling, $\\lambda_{HHH}$ can be constrained to $0.2 < \\lambda_{HHH}/\\lambda^{SM}_{HHH} < 7.0$ $(−3.5 < \\lambda_{HHH}/\\lambda^{SM}_{HHH} < 11)$. The sensitivity of the analysis to increasing trigger thresholds has been studied. The jet pT requirement of the projected High-Luminosity LHC trigger increases the cross-section limit by a factor 1.3 (2.2).

  15. New physics effects in the Higgs trilinear self-coupling through one-loop radiative corrections

    CERN Document Server

    Moyotl, A; Castilla-Valdez, H; Pérez, M A

    2016-01-01

    We compute the one-loop corrections to the triple Higgs self-interaction $hhh$ in the framework of the Standard Model (SM), the Two Higgs Doublet Model type III (THDM-III) and the Littlest Higgs Model with T parity (LHBM+T). Our results are compared with previous results for the SM. In particular, we find that an imaginary part for the $\\lambda_{hhh}$ form factor is induced when one of the Higgs boson legs is off-mass shell with 4-momentum magnitude higher than the Higgs boson mass. This contribution is sensitive to virtual effects of the Higgs self-interaction, that induces a radiative correction to the $hhh$ coupling of order 11%. However, the radiative corrections associated to the new degrees of freedom of the THDM-III and the LHBM+T are rather smaller and comparable to the $W^\\pm$ and $Z^0$ gauge bosons one-loop corrections.

  16. Test of the triple Higgs boson form factor in $\\mu^-\\mu^+\\to HH$

    CERN Document Server

    Gounaris, G J

    2016-01-01

    We study the sensitivity of the process $\\mu^-\\mu^+\\to HH$ to the $q^2$-dependence of the $HHH$ form factor, which can reflect the Higgs boson structure, especially in the case of compositeness. We compute the Born and 1 loop SM contribution to this process. We then show how the $\\mu^-\\mu^+\\to HH$ polarized and unpolarized cross sections are modified by the presence of various types of anomalous contributions to the $HHH$ form factor, in particular Higgs constituents in the case of compositeness.

  17. Higgs boson pair production at the Photon Linear Collider in the two Higgs doublet model

    CERN Document Server

    Asakawa, Eri; Kanemura, Shinya; Okada, Yasuhiro; Tsumura, Koji

    2009-01-01

    We calculate the cross section of the lightest Higgs boson pair production at the Photon Linear Collider in the two Higgs doublet model. We focus on the scenario in which the lightest Higgs boson has the standard model like couplings to gauge bosons. We take into account the one-loop correction to the $hhh$ coupling as well as additional one-loop diagrams due to charged bosons to the $\\gamma\\gamma \\to hh$ helicity amplitudes. We discuss the impact of these corrections on the $hhh$ coupling measurement at the Photon Linear Collider.

  18. A new direct absorption tunable diode laser spectrometer for high precision measurement of water vapor in the upper troposphere and lower stratosphere

    Science.gov (United States)

    Sargent, M. R.; Sayres, D. S.; Smith, J. B.; Witinski, M.; Allen, N. T.; Demusz, J. N.; Rivero, M.; Tuozzolo, C.; Anderson, J. G.

    2013-07-01

    We present a new instrument for the measurement of water vapor in the upper troposphere and lower stratosphere (UT/LS), the Harvard Herriott Hygrometer (HHH). HHH employs a tunable diode near-IR laser to measure water vapor via direct absorption in a Herriott cell. The direct absorption technique provides a direct link between the depth of the observed absorption line and the measured water vapor concentration, which is calculated based on spectroscopic parameters in the HITRAN database. While several other tunable diode laser (TDL) instruments have been used to measure water vapor in the UT/LS, HHH is set apart by its use of an optical cell an order of magnitude smaller than those of other direct absorption TDLs in operation, allowing for a more compact, lightweight instrument. HHH is also unique in its integration into a common duct with the Harvard Lyman-α hygrometer, an independent photo-fragment fluorescence instrument which has been thoroughly validated over 19 years of flight measurements. The instrument was flown for the first time in the Mid-latitude Airborne Cirrus Properties Experiment (MACPEX) on NASA's WB-57 aircraft in spring, 2011, during which it demonstrated in-flight precision of 0.1 ppmv (1 s) with 1-sigma uncertainty of 5% ± 0.7 ppmv. Since the campaign, changes to the instrument have lead to improved accuracy of 5% ± 0.2 ppmv as demonstrated in the laboratory. During MACPEX, HHH successfully measured water vapor at concentrations from 3.5 to 600 ppmv in the upper troposphere and lower stratosphere. HHH and Lyman-α, measuring independently but under the same sampling conditions, agreed on average to within 1% at water vapor mixing ratios above 20 ppmv and to within 0.3 ppmv at lower mixing ratios. HHH also agreed with a number of other in situ water vapor instruments on the WB-57 to within their stated uncertainties, and to within 0.7 ppmv at low water. This agreement constitutes a significant improvement over past in situ comparisons, in

  19. Data of evolutionary structure change: 1EUZB-1HRDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1EUZB-1HRDA 1EUZ 1HRD B A IDPFEMAVKQLERAAQYMDISEEALEW------------...EVITEKNADNI---KAKIVAEVANGPVTPEADDILREK-GILQIPDFLCNAGGVTVSYFEWVQNINGYYWTEEEVREKLDKKMTKAFWEVYNTHKDKNI--HMRDAAY...ain>B 1EUZB KDKNI--HMRDA H...LA CA 431 1HRD A 1HRDA... 1HRDA RKIVG--GFYNG HHH --

  20. Data of evolutionary structure change: 1EUZE-1HRDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1EUZE-1HRDA 1EUZ 1HRD E A IDPFEMAVK--------------QLERAAQYMDISEEAL...EVITEKNADNI---KAKIVAEVANGPVTPEADDILREK-GILQIPDFLCNAGGVTVSYFEWVQNINGYYWTEEEVREKLDKKMTKAFWEVYNTHKDKNI--HMRDAAY...bChain> 1EUZE KDKNI--HMRDA HH -- HHHH...e>ALA CA 440 1HRD A 1HRDA...>A 1HRDA RKIVG--GFYNG HHH

  1. Data of evolutionary structure change: 1AHAA-3CTKA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available K A 3CTKA AVFLDKVPTVAT ...1AHAA-3CTKA 1AHA 3CTK A A --DVSFRLSGADPRSYGMFIKDLRNALPFREKVYNIPLL...FKYIETEVVDRGLYGSFKPNFKVLNLENNWGDISDAIHKSSPQCTTINPALQLISPSNDPWVVNKVS--QISPDMGILKFKS-- -- EEE HHH...yIDChain>1AHAA SYFFN--EPAAE ure>EEEE -- HH... ALA CA 310 ALA CA 375 GLU CA 295 3CT

  2. Data of evolutionary structure change: 1AVSB-2CTNA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1AVSB-2CTNA 1AVS 2CTN B A -QQAEAR-AFLSEEMIAEFKAAFDMFDAD-GGGDISTKE...B 1AVSB MFDAD-GGGDI ...ure>HH - EEEure> ATOM 805 CA MET B 28 -.../entryChain> 2CTN A 2CTNA IFVLGAEDGSI ure>HHH ure>

  3. Data of evolutionary structure change: 1MRJA-3CTKA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available bChain>A 3CTKA EVVDRGLYGSF ure>HHHH ...D> A 3CTKA AVFLD-KVPTV ...1MRJA-3CTKA 1MRJ 3CTK A A --DVSFRLSGATSSSYGVFISNLRKALPNERKLYDIPLL...IETEVVDRGLYGSFKPNFKVLNLENNWGDISDAIHKSSPQCTTINPALQLISPSNDPWVVNKVSQI--SPDMGILKFKS--- -- EEE HHHHH...ryIDChain>1MRJA TTLFY--YNANS ure>HHHH -- HHH

  4. Data of evolutionary structure change: 1CTWA-205LA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available W A 1CTWA GHLLTKSPSLNAA ...1CTWA-205LA 1CTW 205L A A MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSL...ain>205LA GHLLT---AAKSA ure> --- HHH LYS CA 187 SER CA 190 ALA CA 268 1CT...ure> HHHHure> A

  5. Data of evolutionary structure change: 1M39A-2CTNA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1M39A-2CTNA 1M39 2CTN A A ---FGDF-----LTVMTQKMSEKDTKEEILKAFKLFDDD...FDDD-ETGKI ure>HH - EEEure> ILE CA 711 2CTN A 2CT...NA IFVLGAEDGSI ...ure>HHH ure> ATOM 378 CA ILE A 26 61.411 -8.917 -7.203 1.00 0.63

  6. Data of evolutionary structure change: 2R9GG-3CTDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available A 3CTDA NPHNY----LQQEY ... 3CTDA LPTDL--IKFWK ure> -- ...2R9GG-3CTDA 2R9G 3CTD G A DAHYDVISAFQKSIRGSDVDAALHYLARLVEAG-DLASI.../pdbID> G 2R9GG LVEAG-DLASI ...ure>HHH - HHHHure> ATOM 8981 CA

  7. Data of evolutionary structure change: 1EDEA-2PSEA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available in>A 1EDEA ERLDL-RNITL ...>HH - EEEe> ATOM 903 CA GLU A 111 31.387 ...ntryIDChain>2PSEA ELLNLPKKIIF EEcture...pdbChain>A 1EDEA PKMVA---QRDQA ucture...>HHH --- HH> ATOM 1790 CA PRO A 223 24.488 106.682 33.117 1

  8. Data of evolutionary structure change: 1AIAB-1YAAA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available ryIDChain> YLLEN-ETTKN >HHHHH- ...ture>HHH ure> ATOM 446 CA LEU A 59 33.287...Chain>B 1AIAB QGFAR-GLEED ...e> - GGe> ATOM 4735 CA GLN B 226 -0.397...>1YAAA QGFATGDLDKD > HHHH>

  9. Data of evolutionary structure change: 1B99C-2AZ1D [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available GSDS--VESAN >E --HHHHH> ATOM 316...>D 2AZ1D HGSDHEDEGANE >E HHH...pdbID>1B99 C 1B99C EELLT-EVKPN ...> - > ATOM 3319 CA GLU C 141 17.330 5.755...DChain>2AZ1D DELVDWDRDAS re>GG EEGGHcture

  10. Data of evolutionary structure change: 1ACMA-3GD5D [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1ACMA-3GD5D 1ACM 3GD5 A D ANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELL...HHH HHHHHHHHHHHHHHHHHHH ----- 0 1ACM... A 1ACMA MLDEK----GIAWS 1 1ACM A 1ACM...391 VAL CA 486 ILE CA 545 ASN CA 529 1ACM

  11. Three-body recombination in spin-polarized atomic hydrogen

    NARCIS (Netherlands)

    Goey, L.P.H. de; Berg, T.H.M. van de; Mulders, N.; Stoof, H.T.C.; Verhaar, B.J.; Glöckle, W.

    1986-01-01

    In view of the failure of the Kagan dipole mechanism to explain the magnetic field dependence of the H+H+H recombination rate in spin-polarized atomic hydrogen, we consider an additional process, the so-called dipole-exchange mechanism. Two simple approaches to estimate its consequences turn out to

  12. Data of evolutionary structure change: 1CEVC-2ZAVB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1CEVC-2ZAVB 1CEV 2ZAV C B MKPISIIGVPMDLGQTRRGVDMGPSAMRYAGVIERLERL...pdbChain> 1CEVC ALTQI---GGYSP --- 1CEVC YLKER-TDGVH HHH - E...confEVID> 2 1CEV C 1CEVC...>C 1CEVC PIGKAERLHEQG

  13. Data of evolutionary structure change: 1CEVC-5RLAC [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1CEVC-5RLAC 1CEV 5RLA C C MKPISIIGVPMDLGQTRRGVDMGPSAMRYAGVIERLERL...dbChain>C 1CEVC ALTQI---GGYSP C 1CEVC YLKER-TDGVH HHH ...pdbChain> 1CEVC LDERN----KTASV ...>1CEV C 1CEVC

  14. 77 FR 59554 - Approval and Promulgation of Implementation Plans; Georgia; Control Techniques Guidelines and...

    Science.gov (United States)

    2012-09-28

    ... Manufacturing. * * * * * * * 391-3-1-.02(2)(hhh) Wood Furniture 4/12/2009 9/28/2012 [Insert citation of..., proposed rulemaking. Specifically, these rules are Rules 391-1-.02(2)(y) Metal Furniture, (ff) Solvent...)(y) VOC Emissions from 3/7/2012 9/28/2012 [Insert citation of Metal Furniture publication]....

  15. Data of evolutionary structure change: 1ATGA-2H5YA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1ATGA-2H5YA 1ATG 2H5Y A A --ELKVVTATNFLGTLEQLAGQFAKQTGHAVVISSGSSG...ntryChain> 1ATG A 1ATGA PGSHW---F...n>A 1ATGA DKLTAQERIVEA HHH...ryChain> 1ATG A 1ATGA 1ATGA KSTAEKANAEQ HHHHHH

  16. Density dependence of clutch size : habitat heterogeneity or individual adjustment?

    NARCIS (Netherlands)

    Both, Christiaan

    1998-01-01

    1.   Two hypotheses have been proposed to explain density-dependent patterns in reproduction. The habitat heterogeneity hypothesis (HHH) explains density-dependent reproduction at the population level from poorer quality territories in hetero geneous environments only being occupied at high

  17. Adult-onset presentation of a hyperornithinemia-hyperammonemia-homocitrullinuria patient without prior history of neurological complications.

    Science.gov (United States)

    Tezcan, Kamer; Louie, Kristal T; Qu, Yong; Velasquez, Jorge; Zaldivar, Frank; Rioseco-Camacho, Natalia; Camacho, José Angel

    2012-01-01

    The Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) syndrome is a disorder of the urea cycle and ornithine degradation pathway caused by mutations in the mitochondrial ornithine transporter, ORNT1 (SLC25A15). In general, the majority of patients with HHH syndrome come to medical attention during infancy or early school years with symptoms such as learning disabilities, changes in cognitive development, spasticity, or liver dysfunction. In this report, we describe a 35-year-old male of Indian descent who was diagnosed with HHH syndrome after he presented to the emergency room with gastroenteritis, disorientation, and slurred speech. Molecular analysis revealed that this patient was heterozygous for two ORNT1 mutations, p.[Gly220Arg(+)Arg275X] (c.[658G>A(+)823C>T]) that had been previously reported in homozygous probands who presented during the first year of life. Cellular studies revealed that the ORNT1 p.Gly220Arg mutation was nonfunctional but targeted to the mitochondria. Given that this patient was a successful college graduate on a vegetarian diet without a prior history of learning or neurological impairment, additional factors such as gene redundancy, environmental, and epigenetic factors may have contributed to the delay in onset of presentation and lack of any previous symptoms. To the best of our knowledge, this is the first reported case of an adult-onset HHH syndrome presentation without a prior history of neurological or cognitive deficiency.

  18. Data of evolutionary structure change: 1DFID-2QIOB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available in>D 1DFID QLGSD--IVLQC >H --EEE ... TLEGQESLVLPC > EEE > 2QIOB GEFVD-TSRDG > GGG- HHH...quence>GDYVNAVTREG > HHHH HHHre...re> ATOM 5902 CA GLN D 54 24.018 -8.532 -20.481 1.00 39.63

  19. Data of evolutionary structure change: 1ACPA-2DEVC [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1ACPA-2DEVC 1ACP 2DEV A C STIEERVKKIIGEQLGVKQEEVTNNASFVEDLGADSLDT...HHH EEE EEEEEEE EEEEEEEEEE -------- 0 1ACP... A 1ACPA EEAEK-----IT...> ARG CA 219 LYS CA 147 THR CA 173 1ACP... A 1ACPA ELVMALEEEFDT

  20. Accelerator Physics Code Web Repository

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, F.; Basset, R.; Bellodi, G.; Benedetto, E.; Dorda, U.; Giovannozzi, M.; Papaphilippou, Y.; Pieloni, T.; Ruggiero, F.; Rumolo, G.; Schmidt, F.; Todesco, E.; Zotter, B.W.; /CERN; Payet, J.; /Saclay; Bartolini, R.; /RAL, Diamond; Farvacque, L.; /ESRF, Grenoble; Sen, T.; /Fermilab; Chin, Y.H.; Ohmi, K.; Oide, K.; /KEK, Tsukuba; Furman, M.; /LBL, Berkeley /Oak Ridge /Pohang Accelerator Lab. /SLAC /TRIUMF /Tech-X, Boulder /UC, San Diego /Darmstadt, GSI /Rutherford /Brookhaven

    2006-10-24

    In the framework of the CARE HHH European Network, we have developed a web-based dynamic accelerator-physics code repository. We describe the design, structure and contents of this repository, illustrate its usage, and discuss our future plans, with emphasis on code benchmarking.

  1. ACCELERATION PHYSICS CODE WEB REPOSITORY.

    Energy Technology Data Exchange (ETDEWEB)

    WEI, J.

    2006-06-26

    In the framework of the CARE HHH European Network, we have developed a web-based dynamic accelerator-physics code repository. We describe the design, structure and contents of this repository, illustrate its usage, and discuss our future plans, with emphasis on code benchmarking.

  2. Data of evolutionary structure change: 1JJIA-3H1BA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available hain> 3H1BA WLLDQ----GFKPQ ...>HHH ---- > ATOM 942 CA TRP A 127 -20.677 16.86...Chain>1JJIA WVAENAEELRIDPS ture>HHHH HHHH ...3H1BA LNGAD-AKHPY >H - HH...ure> GGGGG HH> ATOM 1801 CA PHE A 223

  3. Data of evolutionary structure change: 1BJJA-1KVXA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available > ITCGK-GTNCE ure>EE - HHHucture> A 1KVXA ITCSSENNACE e>EEEE HHH...dbID> A 1KVXA CFSKV--PYNKE ...>HGGG -- GG> ATOM 796 CA CYS A 105 19.389 16.712 15.6...IDChain> CFRRNLDTYNNG >HHHH GGG GG>

  4. Disease: H01268 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H01268 Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome; HHH syndrome Hyperornithinemia-hype... from modeling human mitochondrial ornithine transporter-1. PLoS One 7:e31048 (2012) PMID:22649802 Camacho J, Rioseco-Camacho N Hype...rornithinemia-Hyperammonemia-Homocitrullinuria Syndrome (1993) ...

  5. Data of evolutionary structure change: 1DEFA-3CMDB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DEFA-3CMDB 1DEF 3CMD A B SVLQ---VLHIPDERLRKVAKPVE-EVN----AEIQRIV...pdbChain> 3CMDB KNSQDPIKAEE HHH HHHH ILE CA 668 3CMD B 3CMDB...MD B 3CMDB DACLGEGEGCLSV 3CMD B 3CMDB VHVPS--SLST

  6. Data of evolutionary structure change: 1AIBB-2AY1B [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1AIBB-2AY1B 1AIB 2AY1 B B MFENITAAPADPILGLADLFRADERPGKINLGIGVYKDE...HHH HHHHHHHH EEEE EEEEEGG HHHHHHHHHHHHH 0 1AIB... B 1AIBB DFSFI--...e>ALA CA 413 THR CA 475 LEU CA 494 1AIB... B 1AIBB GSALINDKRARTA <

  7. Data of evolutionary structure change: 1CTWA-1SX2A [Confc[Archive

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  8. Data of evolutionary structure change: 1AHBA-3CTKA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available K A 3CTKA AVFLDKVPTVAT ...1AHBA-3CTKA 1AHB 3CTK A A --DVSFRLSGADPRSYGMFIKDLRNALPFREKVYNIPLL...FKYIETEVVDRGLYGSFKPNFKVLNLENNWGDISDAIHKSSPQCTTINPALQLISPSNDPWVVNKVS--QISPDMGILKFKS-- -- EEE HHH...in>1AHBA SYFFN--EPAAE ure>EEEE -- HHALA CA 311 ALA CA 377 GLU CA 294 3CT

  9. Resonance Production of Three Neutral Supersymmetric Higgs Bosons at LHC

    CERN Document Server

    Cynolter, G; Pócsik, G

    2000-01-01

    Multiple production of Higgs particles is essential to study Higgsself-couplings at future high-energy colliders. In this paper we calculated theresonance contributions to the production of three lightest neutralsupersymmetric Higgs bosons in gluon fusion at LHC. The cross sections due totrilinear Higgs couplings is sizeable but the measurement of the quarticcoupling hhhH(h) seems to be impossible.

  10. Data of evolutionary structure change: 1SPXA-3GRPA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1SPXA-3GRPA 1SPX 3GRP A A --TRFAEKVAIITGSSNGIGRATAVLFAREGAKVTITGR...CA 127 SER CA 177 TYR CA 211 ASP CA 201 3GRP... A 3GRPA NAGITVRM...ine>VAL CA 575 ASN CA 567 3GRP A 3GRPA MMRRRYGRIIN HHH

  11. Data of evolutionary structure change: 1OZHA-1UPCD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZHA-1UPCD 1OZH 1UPC A D VRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLL...>LYS CA 249 VAL CA 284 1UPC D... 1UPCD LLGSSEGIDTPNPP HHH ... ILE CA 324 ASP CA 254 1UPC D 1UPCD GVVADGWQKAAD

  12. Data of evolutionary structure change: 1OZHC-1UPCB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZHC-1UPCB 1OZH 1UPC C B VRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLL...ine>LYS CA 250 VAL CA 278 1UPC B 1UPCB LLGSSEGIDTPN HHH...ine>ALA CA 186 MET CA 181 1UPC B 1UPCB TPNPPANTPAKP

  13. Data of evolutionary structure change: 1DTHB-3B8ZB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available entryIDChain>1DTHB NGFYR----SLNIH >HHH ---- E...dbID>3B8Z B 3B8ZB NRLYSHASIENHIR ...>HHHH GGG EEEucture> ATOM 1942 CA ASN B 299 2...n> 1DTHB EIWSN-EDQIN ...>EE - > ATOM 2052 CA GLU B 57 6.491 46.203 49.509 1.0

  14. Higgs self-coupling in the MSSM and NMSSM after the LHC Run 1

    CERN Document Server

    Wu, Lei; Yuan, Chien-Peng; Zhang, Mengchao

    2015-01-01

    We examine the trilinear self-coupling of the SM-like 125 GeV Higgs boson ($h$) in the minimal supersymmetric model (MSSM) and the next-to-minimal supersymmetric model (NMSSM) after the LHC Run-1. Considering the current experimental constraints, such as the Higgs data, the flavor constraints, the electroweak precision observables as well as the dark matter detections, we scan over the parameter space and obtain the following observations: (1) In the MSSM, the self-coupling is suppressed relative to the SM value. But, due to the tightly constrained parameter space, such a suppression is rather weak and the ratio $\\lambda^{\\rm MSSM}_{hhh}/\\lambda^{\\rm SM}_{hhh}$ is above 0.97; (2) In the NMSSM with $\\lambda0.7$ (also called $\\lambda$-SUSY), the self-coupling can be greatly suppressed or enhanced relative to the SM value (with the ratio $\\lambda^{\\rm NMSSM}_{hhh}/\\lambda^{\\rm SM}_{hhh}$ varying from -1.1 to 1.9), accompanied by a sizable change in $h\\tau^+\\tau^-$ coupling.

  15. Remarkable improvement of methylglyoxal synthase thermostability by His-His interaction.

    Science.gov (United States)

    Mohammadi, Malihe; Kashi, Mona Atabakhshi; Zareian, Shekufeh; Mirshahi, Manoochehr; Khajeh, Khosro

    2014-01-01

    Lately it has been proposed that interaction between two positively charged side chains can stabilize the folded state of proteins. To further explore this point, we studied the effect of histidine-histidine interactions on thermostability of methylglyoxal synthase from Thermus sp. GH5 (TMGS). The crystal structure of TMGS revealed that His23, Arg22, and Phe19 are in close distance and form a surface loop. Here, two modified enzymes were produced by site-directed mutagenesis (SDM); one of them, one histidine (TMGS-HH(O)), and another two histidines (TMGS-HHH(O)) were inserted between Arg22 and His23 (H(O)). In comparison with the wild type, TMGS-HH(O) thermostability increased remarkably, whereas TMGS-HHH(O) was very unstable. To explore the role of His23 in the observed phenomenon, the original His23 in TMGS-HHH(O) was replaced with Ala (TMGS-HHA). Our data showed that the half-life of TMGS-HHA decreased in relation to the wild type. However, its half-life increased in comparison with TMGS-HHH(O). These results demonstrated that histidine-histidine interactions at position 23 in TMGS-HH(O) probably have the main role in TMGS thermostability.

  16. Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding.

    Science.gov (United States)

    Rajan, Rakhi; Taneja, Bhupesh; Mondragón, Alfonso

    2010-07-14

    Topoisomerase V is an archaeal type I topoisomerase that is unique among topoisomerases due to presence of both topoisomerase and DNA repair activities in the same protein. It is organized as an N-terminal topoisomerase domain followed by 24 tandem helix-hairpin-helix (HhH) motifs. Structural studies have shown that the active site is buried by the (HhH) motifs. Here we show that the N-terminal domain can relax DNA in the absence of any HhH motifs and that the HhH motifs are required for stable protein-DNA complex formation. Crystal structures of various topoisomerase V fragments show changes in the relative orientation of the domains mediated by a long bent linker helix, and these movements are essential for the DNA to enter the active site. Phosphate ions bound to the protein near the active site helped model DNA in the topoisomerase domain and show how topoisomerase V may interact with DNA.

  17. Data of evolutionary structure change: 1GB7A-2G4NF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1GB7A-2G4NF 1GB7 2G4N A F KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYN...HHH - GGGG -- EVID>EVID> 0 2G4N F 2G4NF IVQNN--...n> 0.7096549868583679 1.3399250507354736 EVID> 1 2G4N F 2G4NF

  18. Data of evolutionary structure change: 1EQEA-2G4NF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1EQEA-2G4NF 1EQE 2G4N A F KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYN...HHH -GGGG -- EVID>EVID> 0 2G4N F 2G4NF VQNND--S...rotation> 1.4860199689865112 3.0474579334259033 EVID> 1 2G4N F 2G4NF

  19. Higgs Pair Production in the $H(\\rightarrow \\tau\\tau)H(\\rightarrow b\\bar{b})$ channel at the High-Luminosity LHC

    CERN Document Server

    The ATLAS collaboration

    2015-01-01

    Prospects studies are presented for the observation of double Higgs production in the channel $H(\\rightarrow b \\overline{b})H(\\rightarrow \\tau \\tau)$ for a total integrated luminosity of 3000~fb$ ^{-1}$ of $\\sqrt{s}=$14~TeV proton-proton collisions at the HL-LHC. A cut-based analysis strategy using MC data and a parametrisation of the ATLAS detector provide assessment to the measurement prospects performed under different assumptions for the trilinear Higgs couplings values. Assuming SM background and SM signal, we expect to set an upper limit of the cross section for the di-Higgs production of $4.3 \\times \\sigma(HH \\rightarrow b\\bar{b}\\tau^+\\tau^-)$ at 95\\% Confidence Level. Using an effective Lagrangian for the Higgs potential, and allowing its trilinear coupling to vary, we can project an exclusion of $\\lambda_{HHH}/\\lambda_{SM} \\leq -4$ and $\\lambda_{HHH}/\\lambda_{SM} \\geq 12$.

  20. Radiative corrections to the Higgs boson couplings in the Higgs triplet model

    CERN Document Server

    Kikuchi, Mariko

    2013-01-01

    We calculate Higgs coupling constants at one-loop level in the Higgs triplet model (HTM) to compare to future collider experiments. We evaluate the decay rate of the standard model (SM)-like Higgs boson ($h$) into diphoton. Renormalized Higgs couplings with the weak gauge bosons $hVV$ ($V=W$\\ and\\ $Z$) and the trilinear coupling $hhh$ are also calculated at the one-loop level in the on-shell scheme. The event rate of the $pp\\rightarrow h \\rightarrow \\gamma\\gamma$ channel in the HTM to the one in the SM can cover the value from the recent LHC data. We find that in the allowed parameter region by the current data, deviations in the one-loop corrected $hVV$ and $hhh$ vertices can be about -1% and +50%, respectively. Magnitudes of these deviations can be enough significant to compare with the precision future data at the International Linear Collider.

  1. Higgs boson pair production at a photon-photon collision in the two Higgs doublet model

    CERN Document Server

    Asakawa, Eri; Kanemura, Shinya; Okada, Yasuhiro; Tsumura, Koji

    2008-01-01

    We calculate the cross section of Higgs boson pair production at a photon collider in the two Higgs doublet model. We focus on the scenario in which the lightest CP even Higgs boson ($h$) has the standard model like couplings to the gauge bosons. We take into account the one-loop correction to the $hhh$ coupling as well as additional one-loop diagrams due to charged Higgs bosons to the $\\gamma\\gamma\\to hh$ helicity amplitudes. It is found that the full cross section can be enhanced by both these effects to a considerable level. We discuss the impact of these corrections on the $hhh$ coupling measurement at the photon collider.

  2. Dicty_cDB: Contig-U14990-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lekhlkkskkinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkil milkq*hhh*sqnplvavlvki...nl*sskyswyfsnsfny**nxik**lk*kktl Frame B: gllekhlkkskkinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkil milkq...qfvqvvqvkmhvnhk liilikrvlkle*kllkiryw*chqrvvlvnqqfhpcyhmvfqreiitppkyly*mlifa vrqfqs*wvlinckl*iqsmvgfhqrcnkqimilk...4 Query: 992 NHDIKVMSVGFLLGTPDAPVIWKGPRKTTMIRRFLKDTFWGKQDYLIIDTPPGTSDEHLS 1171 ++...Contig-U14990-1 no gap 1568 4 3104178 3102621 MINUS 5 8 U14990 0 0 2 0 3 0 0 0 0 0

  3. Effects of Enhanced Oxygen Delivery by Perfluorocarbons in Spinal Cord Injury

    Science.gov (United States)

    2013-10-01

    shown that the pressure of oxygen levels dissolved in the blood in spinal cord injury dropped profoundly from 21.4 to 10.4 mm Hg almost immediately...control the overall type I error of 5%. Data normality was checked in each outcome. SAS 9.2 was used for all analyses . Results Intravenously...which might have beneficial effect, as in the HHH therapy used in treating vasospasm after rupture of an intracranial aneurysm. Also behavioral testing

  4. Residual-based Methods for Controlling Discretization Error in CFD

    Science.gov (United States)

    2015-08-24

    cjroy@vt.edu Co-I: Jeff Borggaard, Interdisciplinary Center for Applied Mathematics , jborggaard@vt.edu Virginia Tech, Blacksburg, Virginia Students...2008). Mathematically rigorous approaches for driving mesh adaptation are discussed in this proposal. Once the strategy for driving the adaption is...GTEE given in Equation (3) gives the continuous residual )()( hhh uuL  (8) which is analogous to the finite element residual (Ainsworth and

  5. Real-Time, General-Purpose, High-Speed Signal Processing Systems for Underwater Research. Proceedings of a Working Level Conference held at Supreme Allied Commander, Atlantic, Anti-Submarine Warfare Research Center (SACLANTCEN) on 18-21 September 1979. Part 1. Sessions I to III.

    Science.gov (United States)

    1979-12-01

    radar processiag (h) 8-1 to 8-6 by RKa-J~rgem Alker NARTIE - Hultiprocesser for high capacity real-time processing i 91 to 94 by TaSgvr Lumdh A modular...H * CREATE REFL. COEF. FOR RAYTRACE ........ * ...................... * * I * DISPLtA REFL. COEF FOR RAYTRACE ...IEEEEEEEEEEEEE Emlllllllllllu -EEIIIIIEEEEE -- Eh~~hh~h ALKER: Correlator for radar processing A MICRO-PROGRAMMABLE CORRELATOR FOR REAL-TIME RADAR

  6. Standardized UXO Technology Demonstration Site, Scoring Record No. 944

    Science.gov (United States)

    2014-08-01

    R xz R yz R y R xy R xz R xy R x mmm R HHH zyxzyx  where mx , my, and mz are the object principal polarizabilities scaled by the transmitter...An APG weather station located approximately 1 mile west of the test site was used to record average temperature and precipitation on a half-hour...hours, while precipitation data represent a daily total amount of rainfall. Hourly weather logs used to generate this summary are provided in Appendix

  7. The effects of a language barrier in a South African district hospital.

    Science.gov (United States)

    Schlemmer, A; Mash, B

    2006-10-01

    Communication between health workers and patients at Hottentots Holland Hospital (HHH) is hindered by staff and patients not speaking the same language. HHH is a district hospital in the Cape Town Metropolitan District of the Western Cape where staff mainly speak Afrikaans or English and a large number of patients mainly Xhosa. The study aimed to explore the effects of this language barrier on health workers and patients at HHH. Three focus group interviews were held with 21 members of staff and 5 in-depth patient interviews were conducted. The language barrier was found to interfere with working efficiently, create uncertainty about the accuracy of interpretation, be enhanced by a lack of education or training, cause significant ethical dilemmas, negatively influence the attitudes of patients and staff towards each other, decrease the quality of and satisfaction with care, and cause cross-cultural misunderstandings. The effects of the language barrier were considerable and persistent despite an official language policy in the province. The training and employment of professional interpreters as well as teaching of basic Xhosa to staff are recommended.

  8. Tuning the decay time of lanthanide-based near infrared luminescence from micro- to milliseconds through d-->f energy transfer in discrete heterobimetallic complexes.

    Science.gov (United States)

    Torelli, Stéphane; Imbert, Daniel; Cantuel, Martine; Bernardinelli, Gérald; Delahaye, Sandra; Hauser, Andreas; Bünzli, Jean-Claude G; Piguet, Claude

    2005-05-20

    Inert and optically active pseudo-octahedral Cr(III)N6 and Ru(II)N6 chromophores have been incorporated by self-assembly into heterobimetallic triple-stranded helicates HHH-[CrLnL3]6+ and HHH-[RuLnL3]5+. The crystal structures of [CrLnL(3)](CF(3)SO(3))(6) (Ln=Nd, Eu, Yb, Lu) and [RuLnL3](CF3SO3)5 (Ln=Eu, Lu) demonstrate that the helical structure can accommodate metal ions of different sizes, without sizeable change in the intermetallic MLn distances. These systems are ideally suited for unravelling the molecular factors affecting the intermetallic nd-->4f communication. Visible irradiation of the Cr(III)N6 and Ru(II)N6 chromophores in HHH-[MLnL3]5/6+ (Ln=Nd, Yb, Er; M=Cr, Ru) eventually produces lanthanide-based near infrared (NIR) emission, after directional energy migration within the complexes. Depending on the kinetic regime associated with each specific d-f pair, the NIR luminescence decay times can be tuned from micro- to milliseconds. The origin of this effect, together with its rational control for programming optical functions in discrete heterobimetallic entities, are discussed.

  9. An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.

    Directory of Open Access Journals (Sweden)

    Tianqiao Song

    2015-12-01

    Full Text Available Oomycete pathogens produce a large number of CRN effectors to manipulate plant immune responses and promote infection. However, their functional mechanisms are largely unknown. Here, we identified a Phytophthora sojae CRN effector PsCRN108 which contains a putative DNA-binding helix-hairpin-helix (HhH motif and acts in the plant cell nucleus. Silencing of the PsCRN108 gene reduced P. sojae virulence to soybean, while expression of the gene in Nicotiana benthamiana and Arabidopsis thaliana enhanced plant susceptibility to P. capsici. Moreover, PsCRN108 could inhibit expression of HSP genes in A. thaliana, N. benthamiana and soybean. Both the HhH motif and nuclear localization signal of this effector were required for its contribution to virulence and its suppression of HSP gene expression. Furthermore, we found that PsCRN108 targeted HSP promoters in an HSE- and HhH motif-dependent manner. PsCRN108 could inhibit the association of the HSE with the plant heat shock transcription factor AtHsfA1a, which initializes HSP gene expression in response to stress. Therefore, our data support a role for PsCRN108 as a nucleomodulin in down-regulating the expression of plant defense-related genes by directly targeting specific plant promoters.

  10. Anomalous $\\omega$-$Z$-$\\gamma$ Vertex from Hidden Local Symmetry

    CERN Document Server

    Harada, Masayasu; Yamawaki, Koichi

    2011-01-01

    We formulate the general form of omega-Z-gamma vertex in the framework based on the hidden local symmetry (HLS), which arises from the gauge invariant terms for intrinsic parity-odd (IP-odd) part of the effective action. Those terms are given as the homogeneous part of the general solution (having free parameters) to the Wess-Zumino (WZ) anomaly equation and hence are not determined by the anomaly, in sharp contrast to the Harvey-Hill-Hill (HHH) action where the relevant vertex is claimed to be uniquely determined by the anomaly. We show that, even in the framework that HHH was based on, the omega-Z-gamma vertex is actually not determined by the anomaly but by the homogeneous (anomaly-free) part of the general solution to the WZ anomaly equation having free parameters in the same way as in the HLS formulation: The HHH action is just a particular choice of the free parameters in the general solution. We further show that the omega-Z-gamma vertex related to the neutrino (nu) - nucleon (N) scattering cross secti...

  11. Modelling large-scale halo bias using the bispectrum

    CERN Document Server

    Pollack, Jennifer E; Porciani, Cristiano

    2011-01-01

    We study the relation between the halo and matter density fields -- commonly termed bias -- in the LCDM framework. In particular, we examine the local model of biasing at quadratic order in matter density. This model is characterized by parameters b_1 and b_2. Using an ensemble of N-body simulations, we apply several statistical methods to estimate the parameters. We measure halo and matter fluctuations smoothed on various scales and find that the parameters vary with smoothing scale. We argue that, for real-space measurements, owing to the mixing of wavemodes, no scale can be found for which the parameters are independent of smoothing. However, this is not the case in Fourier space. We measure halo power spectra and construct estimates for an effective large-scale bias. We measure the configuration dependence of the halo bispectra B_hhh and reduced bispectra Q_hhh for very large-scale k-space triangles. From this we constrain b_1 and b_2. Using the lowest-order perturbation theory, we find that for B_hhh the...

  12. Radiative corrections to the Higgs boson couplings in the triplet model

    CERN Document Server

    Aoki, Mayumi; Kikuchi, Mariko; Yagyu, Kei

    2012-01-01

    We calculate a full set of one-loop corrections to the Higgs boson coupling constants as well as the electroweak parameters. We compute the decay rate of the standard model (SM)-like Higgs boson ($h$) into diphoton. Renormalized Higgs couplings with the weak gauge bosons $hVV$ ($V=W$ and $Z$) and the trilinear coupling $hhh$ are also calculated at the one-loop level in the on-shell scheme. Magnitudes of the deviations in these quantities are evaluated in the parameter regions where the unitarity and vacuum stability bounds are satisfied and the predicted W boson mass at the one-loop level is consistent with the data. We find that there are strong correlations among deviations in the Higgs boson couplings $h\\gamma\\gamma$, $hVV$ and $hhh$. For example, if the event number of the $pp\\to h\\to\\gamma\\gamma$ channel deviates by +30% (-40%) from the SM prediction, deviations in the one-loop corrected $hVV$ and $hhh$ vertices are predicted about -0.1% (-2%) and -10% $(+150%)$, respectively. The model can be discrimina...

  13. Fitting the Two-Higgs-Doublet model of type II

    CERN Document Server

    Eberhardt, Otto

    2014-01-01

    We present the current status of the Two-Higgs-Doublet model of type II. Taking into account all available relevant information, we exclude at $95$% CL sizeable deviations of the so-called alignment limit, in which all couplings of the light CP-even Higgs boson $h$ are Standard-Model-like. While we can set a lower limit of $240$ GeV on the mass of the pseudoscalar Higgs boson at $95$% CL, the mass of the heavy CP-even Higgs boson $H$ can be even lighter than $200$ GeV. The strong constraints on the model parameters also set limits on the triple Higgs couplings: the $hhh$ coupling in the Two-Higgs-Doublet model of type II cannot be larger than in the Standard Model, while the $hhH$ coupling can maximally be $2.5$ times the size of the Standard Model $hhh$ coupling, assuming an $H$ mass below $1$ TeV. The selection of benchmark scenarios which maximize specific effects within the allowed regions for further collider studies is illustrated for the $H$ branching fraction to fermions and gauge bosons. As an exampl...

  14. Non-decoupling effects in supersymmetric Higgs sectors

    CERN Document Server

    Kanemura, Shinya; Yagyu, Kei

    2010-01-01

    A wide class of Higgs sectors is comprehensively investigated in the decoupling region in supersymmetric standard models. The mass ($m_h$) of the lightest Higgs boson ($h$) as well as the triple Higgs boson coupling (the $hhh$ coupling) are evaluated at the one-loop level in each model. While $m_h$ is at most 120-130 GeV in the minimal supersymmetric standard model (MSSM), that in models with an additional singlet or triplet fields can be much larger. The $hhh$ coupling can also be sensitive to the models: while in the MSSM the deviation from the standard model prediction is not significant, that can be 30-60 \\% in some models such as that with the additional singlet or with extra doublets and charged singlets. These models are motivated by specific physics problems. Therefore, when $h$ is found at the CERN Large Hadron Collider, we may be able to discriminate supersymmetric models by measuring $m_h$ and the $hhh$ coupling accurately at future collider experiments.

  15. Neutral Higgs Boson Pair-Production and Trilinear Self-Couplings in the MSSM at ILC and CLIC Energies

    CERN Document Server

    Gutiérrez-Rodríguez, A; Sampayo, O A

    2009-01-01

    We study pair-production as well as the triple self-couplings of the neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) at the Future International Linear $e^{+}e^{-}$ Collider (ILC) and Compact Linear Collider (CLIC). The analysis is based on the reactions $e^{+}e^{-}\\to b \\bar b h_ih_i, t \\bar t h_ih_i$ with $h_i=h, H, A$. We evaluate the total cross-section for both $b\\bar bh_ih_i$, $t\\bar th_ih_i$ and calculate the total number of events considering the complete set of Feynman diagrams at tree-level. We vary the triple couplings $\\kappa\\lambda_{hhh}$, $\\kappa\\lambda_{Hhh}$, $\\kappa\\lambda_{hAA}$, $\\kappa\\lambda_{HAA}$, $\\kappa\\lambda_{hHH}$ and $\\kappa\\lambda_{HHH}$ within the range $\\kappa=-1$ and +2. The numerical computation is done for the energies expected at the ILC with a center-of-mass energy 500, 1000, 1600 $GeV$ and a luminosity 1000 $fb^{-1}$. The channels $e^{+}e^{-}\\to b \\bar b h_ih_i$ and $e^{+}e^{-}\\to t \\bar t h_ih_i$ are also discussed to a center-of-mass energy of 3...

  16. The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition.

    Science.gov (United States)

    Das, Devashish; Folkers, Gert E; van Dijk, Marc; Jaspers, Nicolaas G J; Hoeijmakers, Jan H J; Kaptein, Robert; Boelens, Rolf

    2012-04-01

    Human XPF/ERCC1 is a structure-specific DNA endonuclease that nicks the damaged DNA strand at the 5' end during nucleotide excision repair. We determined the structure of the complex of the C-terminal domain of XPF with 10 nt ssDNA. A positively charged region within the second helix of the first HhH motif contacts the ssDNA phosphate backbone. One guanine base is flipped out of register and positioned in a pocket contacting residues from both HhH motifs of XPF. Comparison to other HhH-containing proteins indicates a one-residue deletion in the second HhH motif of XPF that has altered the hairpin conformation, thereby permitting ssDNA interactions. Previous nuclear magnetic resonance studies showed that ERCC1 in the XPF-ERCC1 heterodimer can bind dsDNA. Combining the two observations gives a model that underscores the asymmetry of the human XPF/ERCC1 heterodimer in binding at an ss/ds DNA junction.

  17. An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.

    Science.gov (United States)

    Song, Tianqiao; Ma, Zhenchuan; Shen, Danyu; Li, Qi; Li, Wanlin; Su, Liming; Ye, Tingyue; Zhang, Meixiang; Wang, Yuanchao; Dou, Daolong

    2015-12-01

    Oomycete pathogens produce a large number of CRN effectors to manipulate plant immune responses and promote infection. However, their functional mechanisms are largely unknown. Here, we identified a Phytophthora sojae CRN effector PsCRN108 which contains a putative DNA-binding helix-hairpin-helix (HhH) motif and acts in the plant cell nucleus. Silencing of the PsCRN108 gene reduced P. sojae virulence to soybean, while expression of the gene in Nicotiana benthamiana and Arabidopsis thaliana enhanced plant susceptibility to P. capsici. Moreover, PsCRN108 could inhibit expression of HSP genes in A. thaliana, N. benthamiana and soybean. Both the HhH motif and nuclear localization signal of this effector were required for its contribution to virulence and its suppression of HSP gene expression. Furthermore, we found that PsCRN108 targeted HSP promoters in an HSE- and HhH motif-dependent manner. PsCRN108 could inhibit the association of the HSE with the plant heat shock transcription factor AtHsfA1a, which initializes HSP gene expression in response to stress. Therefore, our data support a role for PsCRN108 as a nucleomodulin in down-regulating the expression of plant defense-related genes by directly targeting specific plant promoters.

  18. Strain-induced Fermi contour anisotropy of GaAs (311)A 2D holes

    Science.gov (United States)

    Shabani, Javad; Shayegan, Mansour; Winkler, Roland

    2008-03-01

    There is considerable current interest in electronic properties of two-dimensional (2D) carriers whose energy bands are spin-split at finite values of in-plane wave vector, thanks to the spin-orbit interaction and the lack of inversion symmetry. We report experimental and theoretical results revealing that the spin-subband Fermi contours of the heavy and light heavy-holes (HHh and HHl) can be tuned in high mobility GaAs (311)A 2D hole systems via the application of symmetry-breaking in-plane strain. Our calculations show that the HHl spin-subband Fermi contour is circular but the HHh spin-subband Fermi contour is distorted. Experimentally, we probe the Fermi contour anisotropy by measuring the magneto-resistance commensurability peaks induced by square arrays of antidots. When the spin splitting is sufficiently large, the magneto-resistance trace exhibits two peaks, providing clear evidence for spin-resolved ballistic transport. The experimental results are in good agreement with the calculations, and confirm that the majority spin-subband (HHh) has a severely distorted Fermi contour whose anisotropy can be tuned with strain while Fermi contour of the minority spin-subband (HHl) remains nearly isotropic.

  19. Comparative analysis of agricultural drought monitoring based on climate and soil moisture indicators in the Huang-Huai-Hai Plain of China

    Science.gov (United States)

    Wu, J.; Zhou, H.; An, X.

    2016-12-01

    Agricultural drought is one of very common agro-meteorological disasters, having a serious threat on crop growth and production. Effective drought monitoring will aid the drought response management to reduce drought loss. Currently there has been many drought indices used for agricultural drought monitoring. Climate-based Standardized Precipitation Evapotranspiration Index (SPEI) was widely used for agricultural drought monitoring in view of its merits of simple calculation, multi-scale and with consideration of evapotranspiration. Besides, soil moisture has been recognized as the most direct indicator for monitoring agricultural drought, which provides a huge potential for monitoring due to the increase of soil moisture accessibility. Given that algorithms of both indices are different and their monitoring results also may exist the discrepancies, it is necessary to analyze their performances of both indices in agricultural drought monitoring. In this study, we chose the climate-based SPEI and soil moisture-based index (SMI) to analyze. Firstly, drought events identified by SPEI and SMI were analyzed from the perspective of drought evolution. Then the performances of SPEI and SMI were assessed through the comparison with observed drought events. Finally, vegetation change since 2000 and impact of drought on vegetation growth in Huang-Huai-Hai (HHH) Plain were explored based on MODIS NDVI data. The results show that SPEI-based drought trend agrees with SMI-based analysis, demonstrating that drought has an alleviating trend in HHH Plain in recent years. The SPEI and SMI could identify most of drought events, whereas the SMI has better performance than SPEI when it comes to drought category. The NDVI in HHH Plain shows an upward trend since 2000 and drought occurred in 2000 causes a decline in vegetation vigor. Both the SPEI and SMI are significantly correlated with NDVI anomaly, and correlation between SMI and NDVI anomaly is slightly higher than that of SPEI.

  20. Studies of the ATLAS potential for Higgs self-coupling measurements at a High Luminosity LHC

    CERN Document Server

    ATLAS, Collaboration; The ATLAS collaboration

    2013-01-01

    Studies are presented on the prospects of measuring the Higgs trilinear self-coupling λHHH in 3,000 fb−1 of 14 TeV proton-proton collisions at the HL-LHC. Two channels are discussed: H(→ bb)H(→ W+W−) and H(→ bb)H(→ γγ). Generator-level Monte Carlo events are used to perform these studies, with parameterised efficiencies and smearings applied to approximate the expected detector performance under HL-LHC conditions.

  1. Measurement and modeling of acid dissociation constants of tri-peptides containing Glu, Gly, and His using potentiometry and generalized multiplicative analysis of variance.

    Science.gov (United States)

    Khoury, Rima Raffoul; Sutton, Gordon J; Hibbert, D Brynn; Ebrahimi, Diako

    2013-02-28

    We report pK(a) values with measurement uncertainties for all labile protons of the 27 tri-peptides prepared from the amino acids glutamic acid (E), glycine (G) and histidine (H). Each tri-peptide (GGG, GGE, GGH, …, HHH) was subjected to alkali titration and pK(a) values were calculated from triplicate potentiometric titrations data using HyperQuad 2008 software. A generalized multiplicative analysis of variance (GEMANOVA) of pK(a) values for the most acidic proton gave the optimum model having two terms, an interaction between the end amino acids plus an isolated main effect of the central amino acid.

  2. Status of Knowledge of Radiation Embrittlement in USA Reactor Pressure Vessel Steels.

    Science.gov (United States)

    1982-02-01

    NRC-FIN-5528 UNCLASSIFIED NRL-R-,737 NUREG -CR-2511 Ni." EEEIIEIIIEI mEE/hhhE AD ~ NUREG /CR-251 1 0 AD A I INRL Memo Rpt 4737 Status of Knowledge of...J2.75 ti a Tec nica for ati Irv Ce Spr ~~~ Sid 1 NUREG /CR-2511 NRL Memo Rpt 4737 R5 Status of Knowledge of Radiation Embrittlement in USA Reactor...vendor reports and correspondence; Commission papers; and applicant and licensee documents and correspondence. The following documents in the NUREG

  3. X-ray diffraction investigations of adherent and free standing TiN coatings deposited by magnetron sputtering

    Energy Technology Data Exchange (ETDEWEB)

    Valvoda, V.; Kuzel, R. Jr.; Dobiasova, L.; Cerny, R. (Charles Univ., Prague (Czechoslovakia). Faculty of Mathematics and Physics); Poulek, V.; Musil, J. (Czechoslovak Academy of Sciences, Prague (Czechoslovakia). Inst. of Physics)

    1990-06-01

    TiN coatings deposited on steel substrates at different biases and temperatures, and with different nitrogen contents, were studied by conventional X-ray powder diffractometry. The diffraction peaks were separated by profile fitting. In adherent films different kinds of texture and a large anisotropy of lattice parameters (a(hhh) < a(h00) < a(hh0)) were detected. In corresponding free-standing films lower average values of lattice parameters were found and their anisotropy decreased considerably. The microstrain determined from X-ray line broadening remained unchanged, which proves its inelastic nature owing to the lattice defects.

  4. On the Taylor Approximation of Control Systems.

    Science.gov (United States)

    1984-01-01

    80-C-0041 UNCLASIFIED 12/EhE~hhhEID S11U MICROCOPY RESOLUTION TEST CHART NATIONAL BUREAU OF STANDARDS-0963.A tliLi ~ ii : MRC Technical Summary Report...control systems, Picard iterates, Taylor expansion. Work Unit Number 5 (Optimization and Large Scale Systems) Istituto di Matematica Applicata...control system on Ad: I _~~d x~)= m g(x(t))ou (t), x(o) = O ii 1 Given a control u, in general there exists no explicit formula to exactly compute the

  5. 78 FR 71510 - Delegation of Authority to the States of Iowa; Kansas; Missouri; Nebraska; Lincoln-Lancaster...

    Science.gov (United States)

    2013-11-29

    ... November 7, 2006. HHH Synthetic Fiber 06/28/11 07/01/08 6/30/11 07/01/09 Production 10/24/12 11/05/10 12/30.../11 07/01/09 07/01/11 Vegetable Oil 10/24/12 12/28/12 12/30/12 12/22/12 09/28/10 04/02/12 Production... 07/01/11 Fibers Production. 10/24/12 12/28/12 12/30/12 12/22/12 MMMMMM Carbon Black 9/19/11 07/01/10...

  6. Quimera de ADN polimerasa del fago ϕ29

    OpenAIRE

    2010-01-01

    Quimera de ADN polimerasa del fago 29. La presente invención se encuadra dentro del campo de la biotecnología. Específicamente, se refiere a una quimera de ADN polimerasa que comprende una región aminoterminal (N-terminal), que codifica para una ADN polimerasa del tipo 29, y una región carboxilo-terminal (C-terminal), que comprende, al menos, un dominio HhH, que se encuentran unidas mediante una secuencia aminoacídica conectora y a su uso para la replicación, amplifi...

  7. Triple Higgs boson production at a 100 TeV proton-proton collider

    CERN Document Server

    Papaefstathiou, Andreas

    2016-01-01

    We consider triple Higgs boson production at a future 100 TeV proton-proton collider. We perform a survey of viable final states and compare and contrast triple production to Higgs boson pair production. Focussing on the $hhh \\rightarrow (b\\bar{b}) (b\\bar{b}) (\\gamma \\gamma)$ final state, we construct a baseline analysis for the Standard Model scenario and simple deformations, demonstrating that the process merits investigation in the high-luminosity phase of the future collider as a new probe of the self-coupling sector of the Higgs boson.

  8. Sensitivity of the decay $h\\to ZZ^*\\to Zl+l-$ to the Higgs self coupling through radiative corrections

    CERN Document Server

    Castilla-Valdez, H; Moyotl, A; Perez, M A

    2015-01-01

    We study the radiative corrections induced by the triple Higgs boson coupling $hhh$ in the three body decay $h\\to ZZ^*\\to Zl\\bar l$. We show that these corrections are potentially sensitive to the specific value of this coupling in the Standard Model and the Two Higgs Doublet Model. These effects may induce corrections to the integrated decay width of the three-body decay of order few percent and thus open a new window to test the Higgs boson self interaction.

  9. 心力衰竭患者中生命体征和心肺信号的家庭远程监控:HHH模式的系统结构和可行性

    Institute of Scientific and Technical Information of China (English)

    Pinna; G.D.; Maestri; R.; Andrews; D.; 王亭忠

    2007-01-01

    背景:心力衰竭的家庭或医院干预研究(HHH)是一项欧洲社区资助性试验(QLGA-CT-2001-02424),这项多中心、多国家(意大利、波兰和英国)、随机对照临床试验比较了心力衰竭(HF)常规干预与三种HF家庭干预。对临床参数进行家庭远程监控(HT)是传

  10. Study of Improved Aluminum Materials for Vehicular Armor

    Science.gov (United States)

    1977-04-07

    103 B17 Procedures Used to Evaluate FTMT Practices on 1.25" Thick 7475 Plate ------------------------------------ 104 B18...and final artificial aging at 250*F for 8, 16, or 24 hrs. The fabricating details are civen in Figure B17 in Appendix B. Grain Size Determinations...rd H WCU 40a) 9 ;,-4d) H4)Q ill 4)1 a, 4.) 4o n 2 0- U) 00l 4U 4 4-40 4 0HHH 4) 4) W0n rd 0 >~4 :z £ 0 4J ( 0 9 0 W E I O OHr 4) -4 H) Wit , H 4 ) H 4

  11. One-loop corrections to the Higgs self-couplings in the singlet extension

    CERN Document Server

    Kanemura, Shinya; Yagyu, Kei

    2016-01-01

    We investigate predictions on the triple Higgs boson couplings with radiative corrections in the model with an additional real singlet scalar field. In this model, the second physical scalar state ($H$) appears in addition to the Higgs boson ($h$) with the mass 125 GeV. The $hhh$ vertex is calculated at the one-loop level, and its possible deviation from the predictions in the standard model is evaluated under various theoretical constraints. The decay rate of $H \\to hh$ is also computed at the one-loop level. We also take into account the bound from the precise measurement of the $W$ boson mass, which gives the upper limit on the mixing angle $\\alpha$ between two physical Higgs bosons for a given value of the mass of $H$ ($m_H^{}$). We find that the deviation in the $hhh$ coupling from the prediction in the standard model can maximally be about 250\\%, 150\\% and 75\\% for $m_H^{}=300$, 500 and 1000 GeV, respectively, under the requirement that the cutoff scale of the model is higher than 3 TeV. We also discuss...

  12. One-Loop Radiative Correction to the Triple Higgs Coupling in the Higgs Singlet Model

    CERN Document Server

    He, Shi-Ping

    2016-01-01

    Though the 125 GeV Higgs boson is consistent with the standard model (SM) prediction until now, the triple coupling can deviate from the SM value in the physics beyond the SM (BSM). In this paper, the radiative correction to the triple Higgs coupling is calculated in the minimal extension of the SM by adding a real gauge singlet scalar. In this model there are two scalars $h$ and $H$ and both of them are mixed states of the doublet and singlet. Provided that the mixing angle is set to be zero, $h$ is the pure left-over of the doublet and its behavior is the same as that of the SM except the triple $h$ couping. In this SM limit case, the effect of the singlet $H$ will decouple from the fermions and gauge bosons, and firstly shown up in the triple $h$ coupling. Our numerical results show that the deviation is sizable. For $\\lambda_{\\Phi{S}}=1$ (see text for the parameter definition), the deviation $\\delta_{hhh}^{(1)}$ can be $40\\%$. For $\\lambda_{\\Phi{S}}=1.5$, the $\\delta_{hhh}^{(1)}$ can reach $140\\%$. The si...

  13. One-loop corrections to the Higgs self-couplings in the singlet extension

    Science.gov (United States)

    Kanemura, Shinya; Kikuchi, Mariko; Yagyu, Kei

    2017-04-01

    We investigate predictions on the triple Higgs boson couplings with radiative corrections in the model with an additional real singlet scalar field. In this model, the second physical scalar state (H) appears in addition to the Higgs boson (h) with the mass 125 GeV. The hhh vertex is calculated at the one-loop level, and its possible deviation from the predictions in the standard model is evaluated under various theoretical constraints. The decay rate of H → hh is also computed at the one-loop level. We also take into account the bound from the precise measurement of the W boson mass, which gives the upper limit on the mixing angle α between two physical Higgs bosons for a given value of the mass of H (mH). We find that the deviation in the hhh coupling from the prediction in the standard model can maximally be about 250%, 150% and 75% for mH = 300, 500 and 1000 GeV, respectively, under the requirement that the cutoff scale of the model is higher than 3 TeV. We also discuss deviations from the standard model prediction in double Higgs boson production from the gluon fusion at the LHC using the one-loop corrected Higgs boson vertices.

  14. 中国不同地区科技示范县大豆单产及产量相关性状的比较%Comparison of Soybean Yield and Yield-related Traits of Agri-technology Demonstration Counties in Different Regions of China

    Institute of Scientific and Technical Information of China (English)

    杨如萍; 宋雯雯; 孙石; 吴存祥; 王化俊; 韩天富; 国家大豆产业技术体系综合试验站

    2012-01-01

    分别于2010和2011年对全国18和20个省(区)的130和141个大豆科技示范县进行抽样调查,收集当地大豆生产田的单产及其相关性状数据.在此基础上,按大豆栽培区划进行分区统计,并采用多元逐步回归方法判断不同地区影响产量的关键因素.结果表明,各地区大豆的播种期因耕作制度不同和气象条件多样而存在很大差异,变化幅度大小依次为南方>西北>东北>黄淮海;东北地区大豆种植密度最高,西北、黄淮海居中,南方最低.平均单产高低依次为西北>东北>黄淮海>南方.在农艺和产量性状中,株高以东北大豆为最高,其后依次为西北、黄淮海和南方;单株荚数与单株粒数2个性状的地域差异趋势一致,2010年均依次为南方>西北>黄淮海>东北,2011年均依次为西北>南方>黄淮海>东北;黄淮海地区大豆的百粒重最高,西北次之,东北及南方则相对偏低.多元逐步回归结果表明,在东北和南方地区,影响大豆产量的首要因素为单株粒数,而在西北及黄淮海地区则为单位面积株数.文中讨论了不同主产区提高大豆单产的主攻方向.%The on-site sample survey of 130 and 141 agri-technology demonstration counties in 18 and 20 provinces(autonomous regions) of China was conducted in 2010 and 2011 , respectively. After the survey, the key yield limiting factors in different production regions were determined with step-wise multiple regression analysis. The results showed that soybean sowing dates were consistent with cultivation conditions and farming system in different regions. The order of the sowing date span was South ( biggest) , Northwest, Northeast and Huang-Huai-Hai( HHH,smallest) region;The plant density was the highest in Northeast, middle in Northwest and HHH regions,and the lowest in South China. Soybean yield was the highest in Northwest, the second in the Northeast, the third in HHH and the lowest in the

  15. Study about composite dyeing of natural dyes%植物染料复合染色的若干问题

    Institute of Scientific and Technical Information of China (English)

    罗勇; 王璐; 贾舜华; 张新龙; 周启澄; 胡晓峰; 赵国瑛

    2009-01-01

    为丰富植物染料的色谱,应用DL-CT蓝色植物染料和HHH-CT黄色植物染料对羊毛织物进行复合染色,研究了复合染色在植物染料上的应用.对DL-CT蓝色植物染料和HHH-CT黄色植物染料复合染色的基本原理和工艺技术进行了探讨.分析了染料用量、媒染剂用量等工艺参数对羊毛织物色泽的影响,并通过正交试验优化了工艺;还对还原性植物染料DL-CT新型染色方法进行了探讨.结果表明:DL-CT蓝色植物染料和HHH-CT黄色植物染料通过复合染色可以得到不同的染色色泽,为丰富植物染料的色谱提供了新的途径.

  16. Influence of anomalous VVH and VVHH on determination of Higgs self couplings at ILC

    CERN Document Server

    Kumar, Satendra

    2014-01-01

    The recent discovery of a Higgs boson at LHC, while establishing the Higgs mechanism as the way of electroweak symmetry breaking, started an era of precision measurements involving the Higgs boson. In an effective Lagrangian framework, we consider the e+e- --> ZHH process, at an ILC running at a centre of mass energy of 800 GeV to investigate the effect of the ZZH and ZZHH couplings on the sensitivity of HHH coupling on this process. Our results show that the sensitivity of the trilinear Higgs self couplings on this process has somewhat strong dependence on the Higgs-gauge boson couplings. Single and two parameter reach of ILC with integrated luminosity of 1000 /fb are obtained on the effective couplings, c6 and cH, which are related to the HHH couplings, indicating how these limits are affected by the presence of anomalous ZZH and ZZHH couplings. The kinematic distributions studied to understand the effect of the anomalous couplings, again, show strong influence of Z-H couplings on the dependence of these di...

  17. ANALYSIS ON THE DEVELOPMENT OF CIRCULAR AGRICULTURE IN HUANG- HAI REGION%黄淮海区域循环农业发展的认识与思考

    Institute of Scientific and Technical Information of China (English)

    郭洪海; 宫志远

    2011-01-01

    Huang - Huai - Hai (HHH) is an important agricultural production region. With regional economic and social development, the utilization of wastes such as the crop straw and livestock manure has been the import topic for the regional sustainable agricultural development. Focusing on the principle of" 4R" advocated by circular agriculture, this paper put forward the spatial scale of circular agriculture development with the" three - in - one" pattern of farm - farmer - countryside, which based on farm, farmer and countryside recycling. The organization form of the development circular agriculture should take the government as the main body, pull farmers, joint cooperative economic organization and guide the agricultural leading enterprises to join. Next 5 - 10 years, the development of the circular agriculture in HHH region should take the circular utilization as the predominant mode which include returning the whole straw into field, using the straw for mushroom and livestock, and also innovate corresponding technologies for comprehensively utilization of agricultural wastes in HHH region.%黄淮海区域是我国重要的农产品生产基地.随着区域经济与社会发展,农作物秸秆和畜禽粪便等大量废弃物的综合利用已成为国家及区域农业可持续发展的重要议题.该文紧紧围绕循环农业所倡导的"4R"原则,提出了以农田循环为基础,链接农户循环,铸造农村循环,构建农田-农户-农村"三位一体"的循环农业发展的空间尺度;循环农业的组织形式应以政府为主体,拉动农户,联动合作经济组织,引导农业龙头企业参与;黄淮海区域未来5~10年循环农业的发展应以秸秆原位全量还田循环利用、秸秆菌业循环利用生产和秸秆养畜循环利用生产等为主导模式,并研发创新相应的接口技术,以期建立黄淮海区域农业废弃物高效利用的循环农业生产模式和体系.

  18. Probing anomalous couplings using di-Higgs production in electron–proton collisions

    Directory of Open Access Journals (Sweden)

    Mukesh Kumar

    2017-01-01

    Full Text Available A proposed high energy Future Circular Hadron-Electron Collider would provide sufficient energy in a clean environment to probe di-Higgs production. Using this channel we show that the azimuthal angle correlation between the missing transverse energy and the forward jet is a very good probe for the non-standard hhh and hhWW couplings. We give the exclusion limits on these couplings as a function of integrated luminosity at a 95% C.L. using the fiducial cross sections. With appropriate error fitting methodology we find that the Higgs boson self coupling could be measured to be ghhh(1=1.00−0.17(0.12+0.24(0.14 of its expected Standard Model value at s=3.5(5.0 TeV for an ultimate 10 ab−1 of integrated luminosity.

  19. AcEST: BP916422 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 31 2.5 sp|P22807|SLOU_DROME Homeobox protein slou OS=Drosophila melanog... 30 3.3 sp|A4ZNR4|NKD2_DANRE Protein naked...rotei... 29 9.6 sp|Q1ZXC2|PABPA_DICDI Polyadenylate-binding protein 1-A OS=Dicty... 29 9.6 sp|Q9VVV9|NKD_DROME Protein naked...S 12 SSS P P S Sbjct: 244 SSSSTAPPSPATSPLS 259 >sp|A4ZNR4|NKD2_DANRE Protein naked cuticle homolog 2 OS=Dani...TH +H +H+H +P HH+H + Sbjct: 32 SVATQPPQSQIPPQPQYQYQMAPPPQTHHVHPHHVHPHHQQHPGYVPSHHHHHQ 85 >sp|Q9VVV9|NKD_DROME Protein naked

  20. Probing anomalous couplings using di-Higgs production in electron-proton collisions

    Science.gov (United States)

    Kumar, Mukesh; Ruan, Xifeng; Islam, Rashidul; Cornell, Alan S.; Klein, Max; Klein, Uta; Mellado, Bruce

    2017-01-01

    A proposed high energy Future Circular Hadron-Electron Collider would provide sufficient energy in a clean environment to probe di-Higgs production. Using this channel we show that the azimuthal angle correlation between the missing transverse energy and the forward jet is a very good probe for the non-standard hhh and hhWW couplings. We give the exclusion limits on these couplings as a function of integrated luminosity at a 95% C.L. using the fiducial cross sections. With appropriate error fitting methodology we find that the Higgs boson self coupling could be measured to be ghhh(1) = 1.00-0.17(0.12)+0.24(0.14) of its expected Standard Model value at √{ s} = 3.5 (5.0) TeV for an ultimate 10 ab-1 of integrated luminosity.

  1. CARE07 Coordinated Accelerator Research in Europe

    CERN Multimedia

    2007-01-01

    Annual Meeting, at CERN, 29-31 October 2007 The CARE project started on 1st January 2004 and will end on 31st December 2008. At the end of each year, the progress and status of its activities are reported in a general meeting. This year, the meeting is taking place at CERN. The CARE objective is to generate structured and integrated European cooperation in the field of accelerator research and related R&D. The programme includes the most advanced scientific and technological developments, relevant to accelerator research for particle physics. It is articulated around three Networking Activities and four Joint Activities. The Networking Activities ELAN, BENE and HHH aim to better coordinate R&D efforts at the European level and to strengthen Europe’s ability to produce intense and high-energy particle beams (electrons and positrons, muons and neutrinos, protons and ions, respectively). The Joint Activities, SRF, PHIN, HIPPI and NED, aim at technical developments ...

  2. CARE07 Coordinated Accelerator Research in Europe

    CERN Multimedia

    2007-01-01

    Annual Meeting, at CERN, 29-31 October 2007 The CARE project started on 1st January 2004 and will end on 31st December 2008. At the end of each year, the progress and status of its activities are reported in a general meeting. This year, the meeting takes place at CERN. The CARE objective is to generate structured and integrated European cooperation in the field of accelerator research and related R&D. The programme includes the most advanced scientific and technological developments, relevant to accelerator research for particle physics. It is articulated around three Networking Activities and four Joint Activities. The Networking Activities ELAN, BENE and HHH aim to better coordinate R&D efforts at the European level and to strengthen Europe’s ability to produce intense and high-energy particle beams (electrons and positrons, muons and neutrinos, protons and ions, respectively). The Joint Activities, SRF, PHIN, HIPPI and NED, aim at technical developments on s...

  3. Omega Navigation System Course Book. Volume 1.

    Science.gov (United States)

    1994-07-01

    antenna must be about 15 percent taller . Figure 3.4-9 is a photograph of a grounded tower antenna systemn at the La Reuinion iransmittingy station. .3...provides the 0-30613 10-2-92 F Indicatec1 Inertial Craft Position + Navigation " Cora ected System Craft Position Position Indicated + Position Error...o0 o0 la Na % ;6 0i0~~oCOC~ H NNa oil r- corA t Cl~𔃺 A0A 9 co HQL (n oHI- HHH~~~~~~~~~~f ClllNMNllll~Nlll(JCi~llA CliC to w N0000000a000& 0’c", 100

  4. First-order electroweak phase transition powered by additional F-term loop effects in an extended supersymmetric Higgs sector

    CERN Document Server

    Kanemura, Shinya; Shindou, Tetsuo

    2011-01-01

    We investigate the one-loop effect of new charged scalar bosons on the Higgs potential at finite temperatures in the supersymmetric standard model with four Higgs doublet chiral superfields as well as a pair of charged singlet chiral superfields. In this model, the mass of the lightest Higgs boson $h$ is determined only by the D-term in the Higgs potential at the tree-level, while the triple Higgs boson coupling for $hhh$ can receive a significant radiative correction due to nondecoupling one-loop contributions of the additional charged scalar bosons. We find that the same nondecoupling mechanism can also contribute to realize stronger first order electroweak phase transition than that in the minimal supersymmetric standard model, which is definitely required for a successful scenario of electroweak baryogenesis. Therefore, this model can be a new candidate for a model in which the baryon asymmetry of the Universe is explained at the electroweak scale.

  5. Measuring the 2HDM Scalar Potential at LHC14

    CERN Document Server

    Barger, Vernon; Jackson, Chris B; Peterson, Andrea D; Shaughnessy, Gabe

    2014-01-01

    After the extraordinary discovery of the Higgs boson at the LHC, the next goal is to pin down its underlying dynamics by measuring the Higgs self-couplings, along with its couplings to gauge and matter particles. As a prototype model of new physics in the scalar sector, we consider the Two Higgs Doublet Model (2HDM) with CP-conservation, and evaluate the prospects for measuring the trilinear scalar couplings among the CP-even Higgs bosons $h$ and $H$ ($\\lambda^{hhh}$, $\\lambda^{hhH}$, $\\lambda^{hHH}$) at LHC14. The continuum and resonant production of CP-even Higgs boson pairs, $hh$ and $hH$, offer complementary probes of the scalar potential away from the light-Higgs decoupling limit. We identify the viable search channels at LHC14 and estimate their expected discovery sensitivities.

  6. On the global stability of the wave-map equation in Kerr spaces with small angular momentum

    CERN Document Server

    Ionescu, A D

    2014-01-01

    This paper is motivated by the problem of the nonlinear stability of the Kerr solution for axially symmetric perturbations. We consider a model problem concerning the axially symmetric perturbations of a wave map $\\Phi$ defined from a fixed Kerr solution $\\KK(M,a)$, $0\\le a < M $, with values in the two dimensional hyperbolic space $\\HHH^2$. A particular such wave map is given by the complex Ernst potential associated to the axial Killing vectorfield $\\Z$ of $\\KK(M,a)$. We conjecture that this stationary solution is stable, under small axially symmetric perturbations, in the domain of outer communication (DOC) of $\\KK(M,a)$, for all $0\\le a

  7. Workshop on Accelerator Magnet Superconductors, Design and Optimization

    CERN Document Server

    WAMSDO Workshop

    2009-01-01

    This report contains the proceedings of the CARE-HHH-AMT Workshop on Accelerator Magnet Superconductors, Design and Optimization (WAMSDO) held at CERN from 19 to 23 May 2008. The needs in terms of superconducting magnets for the accelerator projects were discussed, mainly for the LHC interaction regions and injector upgrades, and for the GSI FAIR complex. The first part of the workshop focused on the development of superconductor and cables, i.e., low-loss Nb-Ti cables, Nb3Sn and high-temperature superconductors. An industry session summarized the actual plans and status of the activities in the main European industries. Then, a worldwide status of the high field magnets programme was presented. A special session was devoted to fast cycled magnets, including FAIR facilities and LHC injector upgrades. A final session focused on the optimization methods and numerical tools for magnet design.

  8. Phenomenological Models of Holographic Superconductors and Hall currents

    CERN Document Server

    Aprile, Francesco; Rodriguez-Gomez, Diego; Russo, Jorge G

    2010-01-01

    We study general models of holographic superconductivity parametrized by four arbitrary functions of a neutral scalar field of the bulk theory. The models can accommodate several features of real superconductors, like arbitrary critical temperatures and critical exponents in a certain range, and perhaps impurities, boundary or thickness effects. We find analytical expressions for the critical exponents of the general model and show that they satisfy the Rushbrooke identity. An important subclass of models exhibits second order phase transitions. A study of the specific heat shows that general models can also describe holographic superconductors undergoing first, second and third (or higher) order phase transitions. We discuss how small deformations of the HHH model lead to the appearance of resonance peaks in the conductivity, which become narrower as the temperature is gradually decreased, without the need for tuning mass of the scalar to be close to the Breitenlohner-Freedman bound. Finally, we investigate ...

  9. Scenarios for sLHC and vLHC

    CERN Document Server

    Scandale, Walter

    2008-01-01

    The projected lifetime of the LHC low-beta quadrupoles and evolution of the statistical error halving time call for an LHC luminosity upgrade by the middle of the coming decade. In the framework of the EU CARE-HHH network, two scenarios have been developed for increasing the LHC peak luminosity by a factor 10, to 1035 cm−2s−1 (“sLHC”). Both scenarios imply a rebuilding of the high-luminosity interaction regions (IRs) in combination with a consistent change of beam parameters. However, their respective features, bunch structures, IR layouts, merits and challenges differ substantially. In either scenario luminosity leveling during a store would be advantageous for the physics experiments. Longer-term R&D efforts are devoted to a higher-energy hadron collider (“vLHC”), which could be realized on a green field or as a later and more radical LHC upgrade.

  10. Searching Heavier Higgs Boson via $H \\to hh \\to WW^*\\gamma\\gamma$ at LHC Run-2

    CERN Document Server

    Lü, Lan-Chun; Fang, Yaquan; He, Hong-Jian; Zhang, Huijun

    2015-01-01

    The LHC discovery of a light Higgs particle $h^0$ (125GeV) opens up new prospect for searching heavier Higgs boson(s) at the LHC Run-2, which will unambiguously point to new physics beyond the standard model (SM). We study the detection of a heavier neutral Higgs boson $H^0$ via di-Higgs production channel at the LHC (14TeV), $H^0 \\to h^0h^0 \\to WW^*\\gamma\\gamma$. This directly probes the $Hhh$ cubic Higgs interaction, which exists in most extensions of the SM Higgs sector. For the decay products of final states $WW^*$, we include both pure leptonic mode $WW^* \\to \\ell\\bar{\

  11. Decoupling Property of SUSY Extended Higgs Sectors and Implication for Electroweak Baryogenesis

    CERN Document Server

    Kanemura, Shinya; Shindou, Tetsuo

    2012-01-01

    One-loop contributions to the Higgs potential at finite temperatures are discussed in the supersymmetric standard model with four Higgs doublet chiral superfields as well as a pair of charged singlet chiral superfields. The mass of the lightest Higgs boson $h$ is determined only by the D-term at the tree-level in this model, while the triple Higgs boson coupling for $hhh$ can receive a significant radiative correction. The same nondecoupling effect can also contribute to realize the sufficient first order electroweak phase transition, which is required for a successful scenario of electroweak baryogenesis. This model can be a new candidate for a model in which the baryon asymmetry of the Universe is explained at the electroweak scale. We also discuss the implication for the measurement of the triple Higgs boson coupling at the ILC.

  12. Production of Light Higgs Pairs in 2-Higgs Doublet Models via the Higgs-strahlung Process at the LHC

    CERN Document Server

    Moretti, M; Piccinini, F; Pittau, R; Rathsman, J

    2010-01-01

    At the Large Hadron Collider, we prove the feasibility to detect pair production of the lightest CP-even Higgs boson h of a Type II 2-Higgs Doublet Model through the process q \\bar q' --> Vhh (Higgs-strahlung, V=W+-,Z), in presence of two h --> b \\bar b decays. We also show that, through such production and decay channels, one has direct access to the following Higgs self-couplings, thus enabling one to distinguish between a standard and the Supersymmetric version of the above model: lambda_(Hhh) -- which constrains the form of the Higgs potential -- as well as lambda_(W+- H+- h) and lambda_(Z A h) -- which are required by gauge invariance. Unfortunately, such claims cannot be extended to the Minimal Supersymmetric Standard Model, where the extraction of the same signals is impossible.

  13. Probing anomalous couplings using di-Higgs production in electron-proton collisions

    CERN Document Server

    Kumar, Mukesh; Islam, Rashidul; Cornell, Alan S; Klein, Max; Klein, Uta; Mellado, Bruce

    2015-01-01

    A proposed high energy Future Circular Hadron-Electron Collider would provide sufficient energy in a clean environment to probe di-Higgs production. Using this channel we show that the azimuthal angle correlation between the missing transverse energy and the forward jet is a very good probe for the non-standard $hhh$ and $hhWW$ couplings. We give the exclusion limits on these couplings as a function of integrated luminosity at 95\\% C.L. using the fiducial cross sections. The Higgs self-coupling could be measured to be within factors of $0.84 \\, (0.89) < \\gonehhh < 1.19 \\, (1.12)$ of its expected Standard Model value at $\\sqrt{s} = 3.5 \\,(5.0)$ TeV for an ultimate 10 $\\abinv$ of integrated luminosity.

  14. Intermolecular triple proton and deuteron transfer in crystalline 3,5-dimethylpyrazole studied by NMR, NQR, and x-ray methods

    Energy Technology Data Exchange (ETDEWEB)

    Wehrle, B.; Aguilar-Parrilla, F.; Limbach, H.H. (Universitaet Freiburg (West Germany)); de la Concepcion Foces-Foces, M.; Cano, F.H. (Instituto Rocasaolano, Madrid (Spain)); Elguero, J. (C.S.I.C., Madrid (Spain)); Baldy, A.; Pierrot, M. (Universite Aix-Marseille III (France)); Khurshid, M.M.T.; Larcombe-McDouall, J.B.; Smith, J.A.S. (King' s College, London (England))

    1989-09-13

    A combination of {sup 13}C, {sup 15}N magnetic resonance, {sup 14}N quadrupole double resonance, and x-ray studies of solid 3,5-dimethylpyrazole between 270 and 350 K has shown that the NH...N hydrogen bond units present in the crystal are dynamically disordered, so that each nitrogen atom is on average attached to half a hydrogen atom. The molecules form discrete hydrogen-bonded cyclic trimers, in which the hydrogen atoms move in a double minimum potential energy surface which is symmetrical, to within experimental error. The experimental evidence in this temperature range is consistent with disorder by means of correlated triple hydrogen jumps with an activation energy of 45 kJ mol{sup {minus}1}. There is a large kinetic hydrogen (HHH)/deuterium (DDD) isotope effort of >20 at 299 K and equal to 8 at 347 K.

  15. GIS-measured walkability, transit, and recreation environments in relation to older Adults' physical activity: A latent profile analysis.

    Science.gov (United States)

    Todd, Michael; Adams, Marc A; Kurka, Jonathan; Conway, Terry L; Cain, Kelli L; Buman, Matthew P; Frank, Lawrence D; Sallis, James F; King, Abby C

    2016-12-01

    An infrequently studied question is how diverse combinations of built environment (BE) features relate to physical activity (PA) for older adults. We derived patterns of geographic information systems- (GIS) measured BE features and explored how they accounted for differences in objective and self-reported PA, sedentary time, and BMI in a sample of older adults. Senior Neighborhood Quality of Life Study participants (N=714, aged 66-97years, 52.1% women, 29.7% racial/ethnic minority) were sampled in 2005-2008 from the Seattle-King County, WA and Baltimore, MD-Washington, DC regions. Participants' home addresses were geocoded, and net residential density, land use mix, retail floor area ratio, intersection density, public transit density, and public park and private recreation facility density measures for 1-km network buffers were derived. Latent profile analyses (LPAs) were estimated from these GIS-based measures. In multilevel regression models, profiles were compared on accelerometer-measured moderate-to-vigorous PA (MVPA) and sedentary time and self-reported PA, adjusting for covariates and clustering. Analyses were conducted in 2014-2015. LPAs yielded three profiles: low walkability/transit/recreation (L-L-L); mean walkability/transit/recreation (M-M-M); and high walkability/transit/recreation (H-H-H). Three PA outcomes were more favorable in the HHH than the LLL profile group (difference of 7.2min/day for MVPA, 97.8min/week for walking for errands, and 79.2min/week for walking for exercise; all ps<0.02). The most and least activity-supportive BE profiles showed greater differences in older adults' PA than did groupings based solely on a 4-component walkability index, suggesting that diverse BE features are important for healthy aging. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. One-loop radiative correction to the triple Higgs coupling in the Higgs singlet model

    Science.gov (United States)

    He, Shi-Ping; Zhu, Shou-hua

    2017-01-01

    Though the 125 GeV Higgs boson is consistent with the standard model (SM) prediction until now, the triple Higgs coupling can deviate from the SM value in the physics beyond the SM (BSM). In this paper, the radiative correction to the triple Higgs coupling is calculated in the minimal extension of the SM by adding a real gauge singlet scalar. In this model there are two scalars h and H and both of them are mixing states of the doublet and singlet. Provided that the mixing angle is set to be zero, namely the SM limit, h is the pure left-over of the doublet and its behavior is the same as that of the SM at the tree level. However the loop corrections can alter h-related couplings. In this SM limit case, the effect of the singlet H may show up in the h-related couplings, especially the triple h coupling. Our numerical results show that the deviation is sizable. For λΦS = 1 (see text for the parameter definition), the deviation δhhh(1) can be 40%. For λΦS = 1.5, the δhhh(1) can reach 140%. The sizable radiative correction is mainly caused by three reasons: the magnitude of the coupling λΦS, light mass of the additional scalar and the threshold enhancement. The radiative corrections for the hVV, hff couplings are from the counter-terms, which are the universal correction in this model and always at O(1%). The hZZ coupling, which can be precisely measured, may be a complementarity to the triple h coupling to search for the BSM. In the optimal case, the triple h coupling is very sensitive to the BSM physics, and this model can be tested at future high luminosity hadron colliders and electron-positron colliders.

  17. Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans.

    Science.gov (United States)

    Moe, Elin; Hall, David R; Leiros, Ingar; Monsen, Vivi Talstad; Timmins, Joanna; McSweeney, Sean

    2012-06-01

    3-Methyladenine DNA glycosylase II (AlkA) is a DNA-repair enzyme that removes alkylated bases in DNA via the base-excision repair (BER) pathway. The enzyme belongs to the helix-hairpin-helix (HhH) superfamily of DNA glycosylases and possesses broad substrate specificity. In the genome of Deinococcus radiodurans, two genes encoding putative AlkA have been identified (Dr_2074 and Dr_2584). Dr_2074 is a homologue of human AlkA (MPG or AAG) and Dr_2584 is a homologue of bacterial AlkAs. Here, the three-dimensional structure of Dr_2584 (DrAlkA2) is presented and compared with the previously determined structure of Escherichia coli AlkA (EcAlkA). The results show that the enzyme consists of two helical-bundle domains separated by a wide DNA-binding cleft and contains an HhH motif. Overall, the protein fold is similar to the two helical-bundle domains of EcAlkA, while the third N-terminal mixed α/β domain observed in EcAlkA is absent. Substrate-specificity analyses show that DrAlkA2, like EcAlkA, is able to remove both 3-methyladenine (3meA) and 7-methylguanine (7meG) from DNA; however, the enzyme possesses no activity towards 1,N(6)-ethenoadenine (ℇA) and hypoxanthine (Hx). In addition, it shows activity towards the AlkB dioxygenase substrates 3-methylcytosine (3meC) and 1-methyladenine (1meA). Thus, the enzyme seems to preferentially repair methylated bases with weakened N-glycosidic bonds; this is an unusual specificity for a bacterial AlkA protein and is probably dictated by a combination of the wide DNA-binding cleft and a highly accessible specificity pocket.

  18. 近20年黄淮海地区气候变暖对夏玉米生育进程及产量的影响%Effects of Climate Warming on Growth Process and Yield of Summer Maize in Huang-Huai-Hai Plain in Last 20 Years

    Institute of Scientific and Technical Information of China (English)

    陆伟婷; 于欢; 曹胜男; 陈长青

    2015-01-01

    东、安徽与江苏夏玉米产量将会下降;整个黄淮海地区,当GDD30上升时,会造成全地区夏玉米产量下降,且山东下降最为明显。【结论】黄淮海地区夏玉米的实际生产受气候变暖的影响,夏玉米对气候变暖是逐步适应,可以利用其适应潜力,通过选育生育期长和耐热的夏玉米品种和改进栽培措施来适应气候变暖,从而提高夏玉米产量。%[Objective]The impacts of climate warming on growth process and yield of summer maize in recent 20 years in Huang-Huai-Hai Plain (HHH) of China, for the purpose of providing a theoretical basis for food security.[Method]Six provinces and regions (Hebei, Henan, Shandong, Anhui and Jiangsu provinces and Beijing-Tianjin region) in HHH Plain were selected as the area for conducting research. Making use of the meteorological observation data and the long-term observation data of summer maize in recent 20 years in HHH Plain, the relationships between climatic factors (temperature and precipitation) and growth process and historical production data during growing season were systematically studied by correlation and nonlinear multiple regression analysis and other statistical methods.[Result]In recent twenty years, an upward trend was found out in the temperature during the growth season of summer maize in Huang-Huai-Hai Plain. The precipitation in northern regions, Beijing-Tianjin region, Hebei and Shandong provinces, was reduced, while it was increased in Henan, Anhui and Jiangsu provinces. Compared to 1990s, the growth process of summer maize in HHH Plain was significantly changed since 2000. The whole growth stages were prolonged with vegetative period shortened by 2 and 1 d in Hebei and Shandong provinces, prolonged by 1 d in Henan province and reproductive stage prolonged by 4 and 2 d in Hebei and Shandong provinces, Henan province remained the same. Different correlations were found between each growth duration and temperature

  19. Numerical Experiment on the Impact of the Urbanizing on Regional Climate and Water Resources in Huanghe-Huaihe-Haihe Zone%大规模城镇化对黄淮海地区气候及水资源影响的数值试验

    Institute of Scientific and Technical Information of China (English)

    陈怀亮; 徐祥德; 李飞; 王兰宁; 杜子璇

    2012-01-01

    Numerical experiment has been carried out over HHH (Huanghe-Huaihe-Haihe) zone by using regional climate model RegCM3 for 5 years (2001-2005). The simulation has two tests, a control test and a sensitivity test on urbanizing conditions. The output results of the regional climate model are precipitation, evaporation, temperature, humidity, soil moisture, runoff, and the total water vapor con-tent. The difference value between sensitivity test and control test responds to the influence of vegetation variation on regional climate and water resources in HHH zone. The results showed that the urbanization could weaken the local wind field, decrease rainfall and water resources and make the temperature in-crease. The variations resulting in the autumn drought happen easily, the floods became more severity be- cause of the increasing of runoff in summer. The urbanization caused the decreasing of soil moisture holding capaci- ty, and stimulated the vegetation degradation greatly. Accordingly, the climate abnormity and the shortening ofwater resources in HHH zone transformed tempestuously, and led to the ecological environment deteriorating.%黄淮海地区是我国传统的农耕区,也是经济快速发展、城镇化进程快速推进的区域之一,使得该地区植被覆盖发生了明显变化。为研究城镇化对气候与水资源的影响,应用RegCM3区域气候模式,通过控制试验和敏感性试验,在保证积分时间(2001-2005年)的情况下,输出降水、蒸发、温度、湿度、土壤水分、径流、整层水汽含量等资料,利用敏感性试验和控制试验输出量的差值,来分析黄淮海地区城镇化对气候和水资源要素的影响情况。结果表明,城镇化对研究地区气候及水资源造成的影响主要表现在使局地风场减弱、降水减少、地面气温增加、空气湿度减小、水资源总量减少、土壤含水量减少和地表径流增加等方面,从而对气候和水资源造成影响。

  20. Neutron scattering investigations of frustated magnets

    Science.gov (United States)

    Fennell, Tom

    This thesis describes the experimental investigation of frustrated magnetic systems based on the pyrochlore lattice of corner-sharing tetrahedra. Ho2Ti207 and Dy2Ti207 are examples of spin ices, in which the manifold of disordered magnetic groundstates maps onto that of the proton positions in ice. Using single crystal neutron scattering to measure Bragg and diffuse scattering, the effect of applying magnetic fields along different directions in the crystal was investigated. Different schemes of degeneracy removal were observed for different directions. Long and short range order, and the coexistence of both could be observed by this technique.The field and temperature dependence of magnetic ordering was studied in Ho2Ti207 and Dy2Ti207. Ho2Ti2()7 has been more extensively investigated. The field was applied on [00l], [hh0], [hhh] and [hh2h]. Dy2Ti207 was studied with the field applied on [00l] and [hho] but more detailed information about the evolution of the scattering pattern across a large area of reciprocal space was obtained.With the field applied on [00l] both materials showed complete degeneracy removal. A long range ordered structure was formed. Any magnetic diffuse scattering vanished and was entirely replaced by strong magnetic Bragg scattering. At T =0.05 K both materials show unusual magnetization curves, with a prominent step and hysteresis. This was attributed to the extremely slow dynamics of spin ice materials at this temperature.Both materials were studied in greatest detail with the field applied on [hh0]. The coexistence of long and short range order was observed when the field was raised at T = 0.05 K. The application of a field in this direction separated the spin system into two populations. One could be ordered by the field, and one remained disordered. However, via spin-spin interactions, the field restricted the degeneracy of the disordered spin population. The neutron scattering pattern of Dy2Ti207 shows that the spin system was separated

  1. A new direct absorption measurement for high precision and accurate measurement of water vapor in the UT/LS

    Science.gov (United States)

    Sargent, M. R.; Sayres, D. S.; Smith, J. B.; Anderson, J.

    2011-12-01

    Highly accurate and precise water vapor measurements in the upper troposphere and lower stratosphere are critical to understanding the climate feedbacks of water vapor and clouds in that region. However, the continued disagreement among water vapor measurements (~1 - 2 ppmv) are too large to constrain the role of different hydration and dehydration mechanisms operating in the UT/LS, with model validation dependent upon which dataset is chosen. In response to these issues, we present a new instrument for measurement of water vapor in the UT/LS that was flown during the April 2011 MACPEX mission out of Houston, TX. The dual axis instrument combines the heritage and validated accuracy of the Harvard Lyman-alpha instrument with a newly designed direct IR absorption instrument, the Harvard Herriott Hygrometer (HHH). The Lyman-alpha detection axis has flown aboard NASA's WB-57 and ER2 aircraft since 1994, and provides a requisite link between the new HHH instrument and the long history of Harvard water vapor measurements. The instrument utilizes the highly sensitive Lyman-alpha photo-fragment fluorescence detection method; its accuracy has been demonstrated though rigorous laboratory calibrations and in situ diagnostic procedures. The Harvard Herriott Hygrometer employs a fiber coupled near-IR laser with state-of-the-art electronics to measure water vapor via direct absorption in a spherical Herriott cell of 10 cm length. The instrument demonstrated in-flight precision of 0.1 ppmv (1-sec, 1-sigma) at mixing ratios as low as 5 ppmv with accuracies of 10% based on careful laboratory calibrations and in-flight performance. We present a description of the measurement technique along with our methodology for calibration and details of the measurement uncertainties. The simultaneous utilization of radically different measurement techniques in a single duct in the new Harvard Water Vapor (HWV) instrument allows for the constraint of systematic errors inherent in each technique

  2. CARE05 coordinated accelerator research in Europe

    CERN Multimedia

    2005-01-01

    Annual Meeting at CERN, 23-25 November 2005 CARE started on 1st January 2004 and will last for five years. At the end of each year it holds a general meeting to report on the progress and status of its activities. This year, the CARE annual meeting is taking place at CERN The objective of the CARE project is to generate structured and integrated European cooperation in the field of accelerator research and related R&D. The program includes the most advanced scientific and technological developments, relevant to accelerator research for Particle Physics. It is articulated around three Networking Activities and four Joint Activities. The Networking Activities ELAN, BENE and HHH aim to better coordinate R&D efforts at the European level and to strengthen Europe's ability to evaluate and develop methods of producing intense and high energy beams of electrons, protons, muons and neutrinos. These activities are embedded in world-wide efforts towards future e+e- linear colliders, superior neutrino beam fa...

  3. Special structures and properties of hydrogen nanowire confined in a single walled carbon nanotube at extreme high pressure

    Directory of Open Access Journals (Sweden)

    Yueyuan Xia

    2012-06-01

    Full Text Available Extensive ab initio molecular dynamics simulations indicate that hydrogen can be confined in single walled carbon nanotubes to form high density and high pressure H2 molecular lattice, which has peculiar shell and axial structures depending on the density or pressure. The band gap of the confined H2 lattice is sensitive to the pressure. Heating the system at 2000K, the H2 lattice is firstly melted to form H2 molecular liquid, and then some of the H2 molecules dissociate accompanied by drastic molecular and atomic reactions, which have essential effect on the electronic structure of the hydrogen system. The liquid hydrogen system at 2000K is found to be a particular mixed liquid, which consists of H2 molecules, H atoms, and H-H-H trimers. The dissociated H atoms and the trimers in the liquid contribute resonance electron states at the Fermi energy to change the material properties substantially. Rapidly cooling the system from 2000K to 0.01 K, the mixed liquid is frozen to form a mixed solid melt with a clear trend of band gap closure. It indicates that this solid melt may become a superconducting nanowire when it is further compressed.

  4. HD/H2 as a probe of the roles of gas, dust, light, metallicity and cosmic rays in promoting the growth of molecular hydrogen in the diffuse interstellar medium

    CERN Document Server

    Liszt, H S

    2014-01-01

    We modelled recent observations of UV absorption of HD and \\HH\\ in the Milky Way and toward damped/sub-damped Lyman alpha systems at z=0.18 and z $>$ 1.7. N(HD)/N(\\HH) ratios reflect the separate self-shieldings of HD and \\HH\\ and the coupling introduced by deuteration chemistry. Locally, observations are explained by diffuse molecular gas with $ 16 \\pccc \\la$ n(H) $\\la 128 \\pccc $ if the cosmic-ray ionization rate per H-nucleus \\zetaH $= 2\\times 10^{-16}\\ps$ as inferred from \\H3\\p\\ and OH\\p. The dominant influence on N(HD)/N(\\HH) is the cosmic-ray ionization rate with a much weaker downward dependence on n(H) at Solar metallicity, but dust-extinction can drive N(HD) higher as with N(\\HH). At z $>$ 1.7, N(HD) is comparable to the Galaxy but with 10x smaller N(\\HH) and somewhat smaller N(\\HH)/N(H I). Comparison of our Galaxy and the Magellanic Clouds shows that smaller \\HH/H is expected at sub-Solar metallicity and we show by modelling that HD/\\HH\\ increases with density at low metallicity, opposite to the Mil...

  5. Calculations of multi-particle processes at the one-loop level: precise predictions for the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Karg, Stefan

    2007-07-01

    We present a calculation of the loop-induced processes gg{yields}HH and gg{yields}HHH, and investigate the observability of multi-Higgs boson production at the LHC in the Standard Model and beyond. While the SM cross sections are too small to allow observation at the LHC, we demonstrate that physics beyond the SM can lead to amplified, observable cross sections. Furthermore, the applicability of the heavy top quark approximation in two- and three-Higgs boson production is investigated. The calculation of the process PP{yields}VV+jet at NLO is an important background process to Higgs production in association with a jet at the LHC. We compute the virtual corrections to this process which form the ''bottleneck'' for obtaining a complete NLO prediction. The resulting analytic expressions are generated with highly automated computer routines and translated into a flexible Fortran code, which can be employed in the computation of differential cross sections of phenomenological interest. (orig.)

  6. Radiative corrections to the Higgs couplings in the triplet model

    CERN Document Server

    Kikuchi, Mariko

    2013-01-01

    The feature of extended Higgs models can appear in the pattern of deviations from the Standard Model (SM) predictions in coupling constants of the SM-like Higgs boson ($h$). We can thus discriminate extended Higgs models by precisely measuring the pattern of deviations in the coupling constants of $h$, even when extra bosons are not found directly. In order to compare the theoretical predictions to the future precision data at the ILC, we must evaluate the theoretical predictions with radiative corrections in various extended Higgs models. In this talk, we give our comprehensive study for radiative corrections to various Higgs boson couplings of $h$ in the minimal Higgs triplet model (HTM). First, we define renormalization conditions in the model, and we calculate the Higgs coupling; $g\\gamma\\gamma, hWW, hZZ$ and $hhh$ at the one loop level. We then evaluate deviations in coupling constants of the SM-like Higgs boson from the predictions in the SM. We find that one-loop contributions to these couplings are su...

  7. Probing triple-Higgs productions via $4b2\\gamma$ at a 100 TeV hadron collider

    CERN Document Server

    Chen, Chien-Yi; Zhao, Xiaoran; Zhong, Yi-Ming; Zhao, Zhijie

    2016-01-01

    The quartic self-coupling of the Standard Model Higgs boson can only be measured by observing the triple-Higgs production process, but it is challenging for the LHC Run 2 or ILC at a few TeV because of its extremely small production rate. In this paper, we present a detailed MC simulation study of the triple-Higgs production through gluon fusion at a 100 TeV hadron collider and explore the feasibility of observing this production mode. We focus on the decay channel $HHH\\rightarrow b\\bar{b}b\\bar{b}\\gamma\\gamma$, investigating detector effects and optimizing the kinematic cuts to discriminate the signal from the backgrounds. Our study shows that in order to observe the Standard Model triple-Higgs signal, the integrated luminosity of a 100 TeV hadron collider should be greater than $1.8\\times 10^4$ ab$^{-1}$. We also explore the dependence of the cross section upon the trilinear ($\\lambda_3$) and quartic ($\\lambda_4$) self-couplings of the Higgs. We find that, through a search in the triple Higgs production, the...

  8. Simulating canopy stomatal conductance of winter wheat and its distribution using remote sensing information

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The canopy stomatal movement, a plant physiological process, generally occurs within leaves but its influence on exchange of CO2, water vapor, and sensible heat fluxes between atmosphere and terrestrial ecosystem. Many studies have documentedthat the interaction between leaf photosynthesis and canopy stomatal conductance is obvious. Thus, information on stomatal conductance is valuable in climate and ecosystem models. In curren study, a newly developed model was adopted to calculate canopy stomatal conductance of winter wheat in Huang-Huai-Hai (H-H-H) Plain of China (31.5-42.7, 110.0-123.0). The remote sensing information from NOAA-AVHRR and meteorological observed data were used to estimate regional scale stomatal conductance distribution. Canopy stomatal conductance distribution pattern of winter wheat onMarch 18, 1997 was also presented. The developed canopy stomatalconductance model might be used to estimate canopy stomatal conductance in land surface schemes and seems can be acted as a boundary condition in regional climatic model runs.

  9. Improved grazing management may increase soil carbon sequestration in temperate steppe.

    Science.gov (United States)

    Chen, Wenqing; Huang, Ding; Liu, Nan; Zhang, Yingjun; Badgery, Warwick B; Wang, Xiaoya; Shen, Yue

    2015-07-03

    Different grazing strategies impact grassland plant production and may also regulate the soil carbon formation. For a site in semiarid temperate steppe, we studied the effect of combinations of rest, high and moderate grazing pressure over three stages of the growing season, on the process involved in soil carbon sequestration. Results show that constant moderate grazing (MMM) exhibited the highest root production and turnover accumulating the most soil carbon. While deferred grazing (RHM and RMH) sequestered less soil carbon compared to MMM, they showed higher standing root mass, maintained a more desirable pasture composition, and had better ability to retain soil N. Constant high grazing pressure (HHH) caused diminished above- and belowground plant production, more soil N losses and an unfavorable microbial environment and had reduced carbon input. Reducing grazing pressure in the last grazing stage (HHM) still had a negative impact on soil carbon. Regression analyses show that adjusting stocking rate to ~5SE/ha with ~40% vegetation utilization rate can get the most carbon accrual. Overall, the soil carbon sequestration in the temperate grassland is affected by the grazing regime that is applied, and grazing can be altered to improve soil carbon sequestration in the temperate steppe.

  10. Ab initio coordination chemistry for nickel chelation motifs.

    Science.gov (United States)

    Sudan, R Jesu Jaya; Kumari, J Lesitha Jeeva; Sudandiradoss, C

    2015-01-01

    Chelation therapy is one of the most appreciated methods in the treatment of metal induced disease predisposition. Coordination chemistry provides a way to understand metal association in biological structures. In this work we have implemented coordination chemistry to study nickel coordination due to its high impact in industrial usage and thereby health consequences. This paper reports the analysis of nickel coordination from a large dataset of nickel bound structures and sequences. Coordination patterns predicted from the structures are reported in terms of donors, chelate length, coordination number, chelate geometry, structural fold and architecture. The analysis revealed histidine as the most favored residue in nickel coordination. The most common chelates identified were histidine based namely HHH, HDH, HEH and HH spaced at specific intervals. Though a maximum coordination number of 8 was observed, the presence of a single protein donor was noted to be mandatory in nickel coordination. The coordination pattern did not reveal any specific fold, nevertheless we report preferable residue spacing for specific structural architecture. In contrast, the analysis of nickel binding proteins from bacterial and archeal species revealed no common coordination patterns. Nickel binding sequence motifs were noted to be organism specific and protein class specific. As a result we identified about 13 signatures derived from 13 classes of nickel binding proteins. The specifications on nickel coordination presented in this paper will prove beneficial for developing better chelation strategies.

  11. Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.

    Science.gov (United States)

    Waisbren, Susan E; Gropman, Andrea L; Batshaw, Mark L

    2016-07-01

    The Urea Cycle Disorders Consortium (UCDC) has conducted, beginning in 2006, a longitudinal study (LS) of eight enzyme deficiencies/transporter defects associated with the urea cycle. These include N-acetylglutamate synthase deficiency (NAGSD); Carbamyl phosphate synthetase 1 deficiency (CPS1D); Ornithine transcarbamylase deficiency (OTCD); Argininosuccinate synthetase deficiency (ASSD) (Citrullinemia); Argininosuccinate lyase deficiency (ASLD) (Argininosuccinic aciduria); Arginase deficiency (ARGD, Argininemia); Hyperornithinemia, hyperammonemia, homocitrullinuria (HHH) syndrome (or mitochondrial ornithine transporter 1 deficiency [ORNT1D]); and Citrullinemia type II (mitochondrial aspartate/glutamate carrier deficiency [CITRIN]). There were 678 UCD patients enrolled in 14 sites in the U.S., Canada, and Europe at the writing of this paper. This review summarizes findings of the consortium related to outcome, focusing primarily on neuroimaging findings and neurocognitive function. Neuroimaging studies in late onset OTCD offered evidence that brain injury caused by biochemical dysregulation may impact functional neuroanatomy serving working memory processes, an important component of executive function and regulation. Additionally, there were alteration in white mater microstructure and functional connectivity at rest. Intellectual deficits in OTCD and other urea cycle disorders (UCD) vary. However, when neuropsychological deficits occur, they tend to be more prominent in motor/performance areas on both intelligence tests and other measures. In some disorders, adults performed significantly less well than younger patients. Further longitudinal follow-up will reveal whether this is due to declines throughout life or to improvements in diagnostics (especially newborn screening) and treatments in the younger generation of patients.

  12. Conceptual design of superferric magnets for PS2

    CERN Document Server

    Bottura, L; Maglioni, C; Parma, V; de Rijk, G; Rossi, L; Scandale, Walter; Serio, L; Tommasini, D

    2007-01-01

    We analyze feasibility and cost of a superferric magnet design for the PS2. Specifically, we provide the conceptual design of dipole and quadrupoles, including considerations on cryogenics and powering. The magnets have warm iron yoke, and cryostated superconducting coils embedded in the magnet, which reduces AC loss at cryogenic temperature. The superconductor has large Operating margin to endure beam loss and operating loads over a long period of time. Although conservative, and without any critical dependence on novel technology developments, this superconducting option appears to be attractive as a low-power alternative to the normal-conducting magnets that are the present baseline for the PS2 design. In addition it provides flexibility in the selection of flat-top duration at no additional cost. This study is the conclusion of the conceptual design work started within the scope of the CARE HHH-AMT activities, following inputs from the workshops ECOMAG and LUMI-06, and finally spurred by the recent discus...

  13. The evolution of internationalization pattern in national technology innovation system in G7 and its inspiration to China%G7国家创新体系国际化模式演化及对中国启示

    Institute of Scientific and Technical Information of China (English)

    孙玉涛; 苏敬勤

    2012-01-01

    以国家技术创新体系国际化概念界定为基础,采用研发强度、技术流动和创新能力作为国际化系统的表征变量,基于二维矩阵识别G7国家技术创新体系国际化模式演化路径;在中国与G7国家创新国际化比较参照系分析的基础上,提出以加拿大和日本国际化路径作为借鉴,中国技术创新体系国际化适合选择LLL→HLL→HHH路径。%This paper uses the RD intensity,technology flow and innovation capacity as the variables of the national technology innovation system(NTIS) internationalization,based on the concept of national innovation system internationalization.Then,it shows evolution paths of internationalization pattern in G7's NTIS using two-dimensional matrix method,and analyses the reference system between China and G7.The result is that China could follow the evolution path of Canada and Japan,and LLL→HLL→HHH path is good choice for China.

  14. Searching heavier Higgs boson via di-Higgs production at LHC Run-2

    Directory of Open Access Journals (Sweden)

    Lan-Chun Lü

    2016-04-01

    Full Text Available The discovery of a light Higgs particle h0(125 GeV opens up new prospect for searching heavier Higgs boson(s at the LHC Run-2, which will unambiguously point to new physics beyond the standard model (SM. We study the detection of a heavier neutral Higgs boson H0 via di-Higgs production channel at the LHC (14 TeV, H0→h0h0→WW⁎γγ. This directly probes the Hhh cubic Higgs interaction, which exists in most extensions of the SM Higgs sector. For the decay products of final states WW⁎, we include both pure leptonic mode WW⁎→ℓν¯ℓ¯ν and semi-leptonic mode WW⁎→qq¯′ℓν. We analyze signals and backgrounds by performing fast detector simulation for the full process pp→H→hh→WW⁎γγ→ℓν¯ℓ¯νγγ and pp→H→hh→WW⁎γγ→ℓνqq¯′γγ, over the mass range MH=250–600 GeV. For generic two-Higgs-doublet models (2HDM, we present the discovery reach of the heavier Higgs boson at the LHC Run-2, and compare it with the current Higgs global fit of the 2HDM parameter space.

  15. Renormalization of the Higgs sector in the triplet model

    CERN Document Server

    Aoki, Mayumi; Kikuchi, Mariko; Yagyu, Kei

    2012-01-01

    We study radiative corrections to the mass spectrum and the triple Higgs boson coupling in the model with an additional Y=1 triplet field. In this model, the vacuum expectation value for the triplet field is strongly constrained from the electroweak precision data, under which characteristic mass spectrum appear at the tree level; i.e., $m_{H^{++}}^2-m_{H^+}^2\\simeq m_{H^+}^2-m_A^2$ and $m_A^2\\simeq m_H^2$, where the CP-even ($H$), the CP-odd ($A$) and the doubly-charged ($H^{\\pm\\pm}$) as well as the singly-charged ($H^\\pm$) Higgs bosons are the triplet-like. We evaluate how the tree-level formulae are modified at the one-loop level. The $hhh$ coupling for the standard model-like Higgs boson ($h$) is also calculated at the one-loop level. One-loop corrections to these quantities can be large enough for identification of the model by future precision data at the LHC or the International Linear Collider.

  16. 上海大众途安巡航控制失效

    Institute of Scientific and Technical Information of China (English)

    陆建平

    2006-01-01

    @@ 一辆途安(1.8T)多用途轻型车,发动机型号BPL,发动机管理系统为博世公司ME7.5,手自排一体6挡变速器09G(HHH). 故障现象:启动发动机怠速运行,将集成在转向灯、变光开关控制手柄上的巡航控制(GRA)主开关由OFF推向ON,仪表显示屏内绿色的巡航灯亮,在车转弯时拨动转向灯开关手柄,当车完成转弯,其开关手柄自动回位时,巡航灯突然熄灭,再怎么拨弄GRA主开关,仪表板内巡航灯都不亮,无法对车辆当前行驶速度进行设定,巡航失效,进厂报修.

  17. Renormalization of the Higgs sector in the triplet model

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, Mayumi [Institute for Theoretical Physics, Kanazawa University, Kanazawa 920-1192 (Japan); Kanemura, Shinya; Kikuchi, Mariko [Department of Physics, University of Toyama, 3190 Gofuku, Toyama 930-8555 (Japan); Yagyu, Kei, E-mail: keiyagyu@jodo.sci.u-toyama.ac.jp [Department of Physics, University of Toyama, 3190 Gofuku, Toyama 930-8555 (Japan); National Central University, Physics and Center for Mathematics and Theoretical Physics, No. 300, Jhongda Rd., Jhongli, Taiwan (China)

    2012-08-14

    We study radiative corrections to the mass spectrum and the triple Higgs boson coupling in the model with an additional Y=1 triplet field. In this model, the vacuum expectation value for the triplet field is strongly constrained from the electroweak precision data, under which characteristic mass spectrum appear at the tree level; i.e., m{sub H{sup +}{sup +2}}-m{sub H{sup +2}} Asymptotically-Equal-To m{sub H{sup +2}}-m{sub A}{sup 2} and m{sub A}{sup 2} Asymptotically-Equal-To m{sub H}{sup 2}, where the CP-even (H), the CP-odd (A) and the doubly-charged (H{sup {+-}{+-}}) as well as the singly-charged (H{sup {+-}}) Higgs bosons are the triplet-like. We evaluate how the tree-level formulae are modified at the one-loop level. The hhh coupling for the standard model-like Higgs boson (h) is also calculated at the one-loop level. One-loop corrections to these quantities can be large enough for identification of the model by future precision data at the LHC or the International Linear Collider.

  18. 兔子! 站住!

    Institute of Scientific and Technical Information of China (English)

    海林

    2012-01-01

    <正>如果你有大把的业余时间,你会选择去干什么?泡吧?K歌?杀人游戏?统统都没意思了,一起来HaSh吧!如果有一天,在公园或者郊外,你看到这样的场景:一群自称"猎狗"的成年人在一起追逐一只或者两只也是成年人扮演的"兔子",还一边跑一边大喊口令,全然不顾旁人惊讶的眼神,游戏结束后违规的人还要被罚酒……你是不是会感觉好奇?一起来吧,他们就是在玩风靡了很久的Hash游戏。Hash是世界性的跑步健身运动,全称是"Hash House Harriers"(简称"Hash"、"HHH",或"3H"),是一项世界性的休闲活动,起源于1938年马

  19. The Experiment of Tonal Elements' Pitch on Tones of Mandarin%普通话声调调素的音高实验

    Institute of Scientific and Technical Information of China (English)

    冯青青

    2015-01-01

    An experimental method is taken to research tonal elements' pitch on modern Chinese mono-syllable tone in this paper,obtaining register feature and arch feature of the tonal element. There are some experimental results. Standard Chinese tones contain three tonal elements,i.e.,high register tonal element H,middle register tonal element M, and low register tonal element L. Standard Chinese tones are represented with tonal elements as followsTone one HHH,Tone two MHH,Tone three LLM,Tone four HML. The tonal element has arch,and every tonal element is flat arch. Tonal arch grundmodus are made up of flat arch.%通过实验方法研究普通话单字调调素的音高,得出调素的音区特征和曲拱特征。实验发现:普通话声调包含三个调素,分别是高音区调素 H、中音区调素 M 和低音区调素 L,普通话四个声调用调素表示为阴平 HHH、阳平 MHH、上声 LLH、去声 HML。调素有曲拱,每个调素都是平拱,各声调的曲拱样态由平拱组合而成。

  20. Generalized support varieties for finite group schemes

    CERN Document Server

    Friedlander, Eric M

    2011-01-01

    We construct two families of refinements of the (projectivized) support variety of a finite dimensional module $M$ for a finite group scheme $G$. For an arbitrary finite group scheme, we associate a family of {\\it non maximal rank varieties} $\\Gamma^j(G)_M$, $1\\leq j \\leq p-1$, to a $kG$-module $M$. For $G$ infinitesimal, we construct a finer family of locally closed subvarieties $V^{\\ul a}(G)_M$ of the variety of one parameter subgroups of $G$ for any partition $\\ul a$ of $\\dim M$. For an arbitrary finite group scheme $G$, a $kG$-module $M$ of constant rank, and a cohomology class $\\zeta$ in $\\HHH^1(G,M)$ we introduce the {\\it zero locus} $Z(\\zeta) \\subset \\Pi(G)$. We show that $Z(\\zeta)$ is a closed subvariety, and relate it to the non-maximal rank varieties. We also extend the construction of $Z(\\zeta)$ to an arbitrary extension class $\\zeta \\in \\Ext^n_G(M,N)$ whenever $M$ and $N$ are $kG$-modules of constant Jordan type.

  1. Higgs Boson Self-Coupling at High Energy $\\gamma \\gamma$ Collider

    CERN Document Server

    Gutierrez-Rodriguez, A; Sampayo, O A

    2011-01-01

    We analyzed the double production and the triple self-coupling of the standard model Higgs boson at future $\\gamma \\gamma$ collider energies, with the reactions $\\gamma\\gamma \\rightarrow f \\bar f HH$ $(f=b, t)$. We evaluated the total cross section for $f\\bar fHH$ and calculated the total number of events considering the complete set of Feynman diagrams at tree-level and for different values of the triple coupling $\\kappa\\lambda_{HHH}$. We have also analyzed the sensitivity for the considered reaction and we show the results as 95% C.L. regions in the $\\kappa-M_H$ plane for different values of the center of mass energy and different levels of background. The numerical computation was done for the energies which are expected to be available at a possible Future Linear $\\gamma\\gamma$ Collider with a center-of-mass energy 500-3000 $GeV$ and luminosities of 1 and $5 ab^{-1}$. We found that the number of events for the process $\\gamma\\gamma \\rightarrow t \\bar t HH$, taking into account the decay products of both $...

  2. DFNA5 and Hereditary Hearing Impairment%DFNA5与遗传性耳聋

    Institute of Scientific and Technical Information of China (English)

    金占国

    2011-01-01

    @@ 遗传性耳聋是危害人类健康的重大疾病之一,根据是否合并其他系统器官疾病,分为综合征性耳聋和非综合征性耳聋,而非综合征性耳聋具有很高的遗传异质性.迄今为止,常染色体显性遗传非综合征性耳聋(DFNA)已成功定位了64个位点,24个基因(Hereditary Hearing Loss Homepage:http://webhost.ua.ac.be/hhh/).第五个常染色体显性遗传非综合征性耳聋基因DFNA 5(OMIM 600994)于1995年在一个高频进展性听力下降的荷兰家系中首先定位在7p15[1],1998年确认了DFNA5的致聋基因[2].本文就已报道DFNA5的基因突变特点、家系的临床特征及目前对该基因功能的研究进展等方面进行综述.

  3. 不同液体复苏方法对孕兔失血性休克各脏器ATP酶活性的影响%Effects of hypotensive or aggressive resuscitation on tissue ATPase activity in pregnant rabbits with uncontrolled hemorrhagic shock

    Institute of Scientific and Technical Information of China (English)

    盛超; 余艳红; 秦薇; 赵克森

    2009-01-01

    目的:探讨限制性液体复苏对非控制性失血性休克孕兔腹腔内失血量、补液量、血细胞比容(Hct)及各脏器Na+-K+-ATP酶活性和Ca2+-Mg2+-ATP酶活性的改变,以分析其对休克后近期能量代谢的影响.方法:将30只孕中晚期新西兰大白兔随机分为5组:(1)假休克组(SS);(2)休克未处理组(SH);(3)传统复苏组(NS);(4)生理盐水限制性输液复苏组(NH);(5)高渗高胶液体限制性复苏组(HHH).实验设计分为休克期(TO-T30 min)、休克复苏期T30(T30-390 min)及休克复苏期T180(T90-T180 min).休克期:除SS组外各组动物均接受离断子宫系膜小动脉及颈动脉放血至平均动脉压(MAP)40-45 mmHg,制作非控制性失血性休克模型.休克复苏期T30:NS组接受生理盐水(4 mL/ks)及林格氏液快速输注以维持MAP在80 mmHg左右;NH、HHH组接受生理盐水(4 mL/kg)或高渗高胶液(6%羟乙基淀粉+7.5%氯化钠)(4 mL/kg)及林格氏液输注以维持MAP在60mmHg左右.休克复苏期T180:除SS组外各组动物均接受手术止血及输血输液治疗.实验中监测血细胞比容(Hct),统计腹腔内失血量、补液量.实验结束后处死动物取心脏、肺脏、肝脏、肾脏、小肠和骨骼肌组织检测Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活性.结果:腹腔内失血量与补液量:NH[(4.3±0.2)mL/kg,(47.2±4.1)mL/kg]与HHH[(4.1 ±0.3)mL/kg,(44.9±4.3)mL/kg]均明显低于NS[(5.5±0.2)mL/kg,(65.5±3.8)mL/lk].T180 min:Hct在NH(21.0%±2.1%)与HHH(21.5%±1.8%)均显著高于NS(14.2%±1.5%)及SH(12.5%±1.4%).失血性休克引起Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活性的升高;其中骨胳肌、心肌、肝、肾组织Na+-K+-ATP酶活力在NH(5.42±1.41,4.54±2.01,4.13±0.62,3.42±0.84)与HHH(3.97±0.91,2.94±0.66,3.22±1.42,3.03±0.53)均显著低于NS(7.34±1.41,6.23±1.53,6.11±0.97,5.82±0.69)与SH(9.11±0.52,8.40±1.08,7.04±1.13,6.55±1.45);肺及肠组织中,NH、HHH、NS组比较无显著差异.结论:孕兔非控制性失血性休克后导致能

  4. Measurement of Higgs couplings and self-coupling at the ILC

    CERN Document Server

    Tian, Junping

    2013-01-01

    In the Standard Model (SM) the couplings of the Higgs boson to SM particles and itself (self-couplings) are uniquely specified once the masses of the particles in question as well as the Higgs boson mass are given. Precision measurements of these couplings in the future collider experiments are the key to either verifying the mechanism of the electroweak symmetry breaking in the SM or uncovering physics beyond the SM. This article gives an overview of how various Higgs couplings will be measured at the ILC. Emphasis is put on the ILC's capability of performing fully model independent determination of absolute $HZZ$ and $HWW$ couplings, the Higgs total width, and hence various other Higgs couplings, which cover essentially all the crucial ones including the top-Yukawa coupling $Htt$ and the trilinear Higgs self-coupling $\\lambda_{HHH}$. The strategy to get the best precision measurements at the ILC is through staged running, which provides many independent $\\sigma\\times\\mathrm{Br}$ measurements for different p...

  5. LHC Upgrade Scenarios

    CERN Document Server

    Zimmermann, F

    2007-01-01

    The EU CARE-HHH and US-LARP studies for an LHC luminosity upgrade aim at increasing the peak luminosity by a factor of 10, to 1035 cm-2s-1. The luminosity can be raised by rebuilding the interaction regions (IRs) in combination with a consistent change of beam parameters. In addition to advanced low-beta quadrupoles, the upgraded IRs may accommodate other new elements such as slim s.c. dipoles or quadrupoles embedded deep inside the detectors, global low-angle crab cavities, and wire compensators of long-range beam-beam effects. Important constraints on the upgrade path are the maximum acceptable number of detector pile-up events, favoring many closely spaced bunches, and the heat load on the cold-magnet beam screens, pointing towards fewer and more intense bunches. In order to translate the increased peak luminosity into a correspondingly higher integrated luminosity, the upgrade of the LHC ring should be complemented by an upgrade of the injector complex. I will present preferred upgrade scenarios for the L...

  6. Benchmarks for Higgs Pair Production and Heavy Higgs Searches in the Two-Higgs-Doublet Model of Type II

    CERN Document Server

    Baglio, Julien; Nierste, Ulrich; Wiebusch, Martin

    2014-01-01

    The search for additional Higgs particles and the exact measurements of Higgs (self-)couplings is a major goal of future collider experiments. In this paper we investigate the possible sizes of new physics signals in these searches in the context of the $CP$-conserving two-Higgs doublet model of type II. Using current constraints from flavour, electroweak precision, and Higgs signal strength data, we determine the allowed sizes of the triple Higgs couplings and the branching fractions of the heavy Higgs bosons into lighter Higgs bosons. Identifying the observed Higgs resonance with the light $CP$-even 2HDM Higgs boson $h$, we find that the $hhh$ coupling cannot exceed its SM value, but can be reduced by a factor of 0.56 at the 2 $\\sigma$ level. The branching fractions of the heavy neutral Higgs bosons $H$ and $A$ into two-fermion or two-vector-boson final states can be reduced by factors of 0.4 and 0.01, respectively, if decays into lighter Higgs boson are possible and if the mass of the decaying Higgs is bel...

  7. Evaluation of halothane as stressor agent in poultry / Avaliação do halotano como agente estressor em frangos

    Directory of Open Access Journals (Sweden)

    Massami Shimokomaki

    2010-07-01

    Full Text Available Studies have been demonstrating in poultry, the existence of at least two causes for the formation of PSE meat: genetic through the sensibility towards halothane and the environmental factor in particular the temperature as the main factor. Thus the objective of this work was to evaluate halothane as stressor agent for broiler concomitantly to evaluating the PSE incidence by submitting these birds to thermal stress. In this experiment, 24 broilers of commercial lineage were divided in 6 animals for 4 treatments: HHH, broilers submitted to halothane test and slaughtered 1h after this test; HET broilers submitted to halothane at 35°C/1h after 48h of halothane test followed by the birds slaughtering; EET, broilers submitted to thermal stress and slaughtered immediately after this treatment, and finally the control treatment (CCC where broilers were not submitted to halothane test nor to thermal stress as control. The initial pH of Pectoralis major m, was evaluated 30 min post mortem and the pH final, color, (L*, a*, b* water holding capacity (WHC, and R value analysis were carried out after 24h of storage of fillet samples at 40C. The pH24h was higher (p ? 0.05 for CCC samples in comparison to other treatments and R value was higher for birds under HET and EET treatments in comparison to CCC (p ? 0.05 suggesting that the rigor mortis was more rapid in samples from birds submitted to thermal stress. The HHH, HET, and EET treatments presented 4 birds each with PSE meat and 2 broilers from CCC treatment originated PSE meat showing the influence not only halothane but also the thermal stress over broilers welfare. Finally, results demonstrated that halothane is a stressor agent as well as the thermal stress and both promoted dramatic biochemical changes bringing about the formation of broiler PSE meat. Resultados vêm mostrando uma direta relação entre a sensibilidade ao halotano e a ocorrência de filés PSE em aves, que pode ser originado pela

  8. Radiative corrections to the Triple Higgs Coupling in the Inert Higgs Doublet Model

    CERN Document Server

    Arhrib, Abdesslam; Falaki, Jaouad El; Jueid, Adil

    2015-01-01

    We investigate the implication of the recent discovery of a Higgs-like particle in the first phase of the LHC Run 1 on the Inert Higgs Doublet Model (IHDM). The determination of the Higgs couplings to SM particles and its intrinsic properties will get improved during the new LHC Run 2 starting this year. The new LHC Run 2 would also shade some light on the triple Higgs coupling. Such measurement is very important in order to establish the details of the electroweak symmetry breaking mechanism. Given the importance of the Higgs couplings both at the LHC and $e^+e^-$ Linear Collider machines, accurate theoretical predictions are required. We study the radiative corrections to the triple Higgs coupling $hhh$ and to $hZZ$, $hWW$ couplings in the context of the IHDM. By combining several theoretical and experimental constraints on parameter space, we show that extra particles might modify the triple Higgs coupling near threshold regions. Finally, we discuss the effect of these corrections on the double Higgs produ...

  9. Ab initio coordination chemistry for nickel chelation motifs.

    Directory of Open Access Journals (Sweden)

    R Jesu Jaya Sudan

    Full Text Available Chelation therapy is one of the most appreciated methods in the treatment of metal induced disease predisposition. Coordination chemistry provides a way to understand metal association in biological structures. In this work we have implemented coordination chemistry to study nickel coordination due to its high impact in industrial usage and thereby health consequences. This paper reports the analysis of nickel coordination from a large dataset of nickel bound structures and sequences. Coordination patterns predicted from the structures are reported in terms of donors, chelate length, coordination number, chelate geometry, structural fold and architecture. The analysis revealed histidine as the most favored residue in nickel coordination. The most common chelates identified were histidine based namely HHH, HDH, HEH and HH spaced at specific intervals. Though a maximum coordination number of 8 was observed, the presence of a single protein donor was noted to be mandatory in nickel coordination. The coordination pattern did not reveal any specific fold, nevertheless we report preferable residue spacing for specific structural architecture. In contrast, the analysis of nickel binding proteins from bacterial and archeal species revealed no common coordination patterns. Nickel binding sequence motifs were noted to be organism specific and protein class specific. As a result we identified about 13 signatures derived from 13 classes of nickel binding proteins. The specifications on nickel coordination presented in this paper will prove beneficial for developing better chelation strategies.

  10. Coronary Arteries Segmentation Based on the 3D Discrete Wavelet Transform and 3D Neutrosophic Transform

    Directory of Open Access Journals (Sweden)

    Shuo-Tsung Chen

    2015-01-01

    Full Text Available Purpose. Most applications in the field of medical image processing require precise estimation. To improve the accuracy of segmentation, this study aimed to propose a novel segmentation method for coronary arteries to allow for the automatic and accurate detection of coronary pathologies. Methods. The proposed segmentation method included 2 parts. First, 3D region growing was applied to give the initial segmentation of coronary arteries. Next, the location of vessel information, HHH subband coefficients of the 3D DWT, was detected by the proposed vessel-texture discrimination algorithm. Based on the initial segmentation, 3D DWT integrated with the 3D neutrosophic transformation could accurately detect the coronary arteries. Results. Each subbranch of the segmented coronary arteries was segmented correctly by the proposed method. The obtained results are compared with those ground truth values obtained from the commercial software from GE Healthcare and the level-set method proposed by Yang et al., 2007. Results indicate that the proposed method is better in terms of efficiency analyzed. Conclusion. Based on the initial segmentation of coronary arteries obtained from 3D region growing, one-level 3D DWT and 3D neutrosophic transformation can be applied to detect coronary pathologies accurately.

  11. Scenarios for the LHC Upgrade

    CERN Document Server

    Scandale, Walter

    2008-01-01

    The projected lifetime of the LHC low-beta quadrupoles, the evolution of the statistical error halving time, and the physics potential all call for an LHC luminosity upgrade by the middle of the coming decade. In the framework of the CARE-HHH network three principal scenarios have been developed for increasing the LHC peak luminosity by more than a factor of 10, to values above 1035 cm−2s−1. All scenarios imply a rebuilding of the high-luminosity interaction regions (IRs) in combination with a consistent change of beam parameters. However, their respective features, bunch structures, IR layouts, merits and challenges, and luminosity variation with β∗ differ substantially. In all scenarios luminosity leveling during a store would be advantageous for the physics experiments. An injector upgrade must complement the upgrade measures in the LHC proper in order to provide the beam intensity and brightness needed as well as to reduce the LHC turnaround time for higher integrated luminosity.

  12. Radiative corrections to the triple Higgs coupling in the inert Higgs doublet model

    Science.gov (United States)

    Arhrib, Abdesslam; Benbrik, Rachid; El Falaki, Jaouad; Jueid, Adil

    2015-12-01

    We investigate the implication of the recent discovery of a Higgs-like particle in the first phase of the LHC Run 1 on the Inert Higgs Doublet Model (IHDM). The determination of the Higgs couplings to SM particles and its intrinsic properties will get improved during the new LHC Run 2 starting this year. The new LHC Run 2 would also shade some light on the triple Higgs coupling. Such measurement is very important in order to establish the details of the electroweak symmetry breaking mechanism. Given the importance of the Higgs couplings both at the LHC and e + e - Linear Collider machines, accurate theoretical predictions are required. We study the radiative corrections to the triple Higgs coupling hhh and to hZZ, hW W couplings in the context of the IHDM. By combining several theoretical and experimental constraints on parameter space, we show that extra particles might modify the triple Higgs coupling near threshold regions. Finally, we discuss the effect of these corrections on the double Higgs production signal at the e + e - LC and show that they can be rather important.

  13. Searching heavier Higgs boson via di-Higgs production at LHC Run-2

    Science.gov (United States)

    Lü, Lan-Chun; Du, Chun; Fang, Yaquan; He, Hong-Jian; Zhang, Huijun

    2016-04-01

    The discovery of a light Higgs particle h0 (125 GeV) opens up new prospect for searching heavier Higgs boson(s) at the LHC Run-2, which will unambiguously point to new physics beyond the standard model (SM). We study the detection of a heavier neutral Higgs boson H0 via di-Higgs production channel at the LHC (14 TeV), H0 →h0h0 → WW* γγ. This directly probes the Hhh cubic Higgs interaction, which exists in most extensions of the SM Higgs sector. For the decay products of final states WW*, we include both pure leptonic mode WW* → ℓ ν bar ℓ bar ν and semi-leptonic mode WW* → qqbar‧ ℓν. We analyze signals and backgrounds by performing fast detector simulation for the full process pp → H → hh → WW* γγ → ℓ ν bar ℓ bar νγγ and pp → H → hh → WW* γγ → ℓνqqbar‧ γγ, over the mass range MH = 250- 600 GeV. For generic two-Higgs-doublet models (2HDM), we present the discovery reach of the heavier Higgs boson at the LHC Run-2, and compare it with the current Higgs global fit of the 2HDM parameter space.

  14. Piezoelectricity and rotostriction through polar and non-polar coupled instabilities in bismuth-based piezoceramics

    Science.gov (United States)

    Acosta, Matias; Schmitt, Ljubomira A.; Cazorla, Claudio; Studer, Andrew; Zintler, Alexander; Glaum, Julia; Kleebe, Hans-Joachim; Donner, Wolfgang; Hoffman, Mark; Rödel, Jürgen; Hinterstein, Manuel

    2016-07-01

    Coupling of order parameters provides a means to tune functionality in advanced materials including multiferroics, superconductors, and ionic conductors. We demonstrate that the response of a frustrated ferroelectric state leads to coupling between order parameters under electric field depending on grain orientation. The strain of grains oriented along a specific crystallographic direction, , is caused by converse piezoelectricity originating from a ferrodistortive tetragonal phase. For hhh> oriented grains, the strain results from converse piezoelectricity and rotostriction, as indicated by an antiferrodistortive instability that promotes octahedral tilting in a rhombohedral phase. Both strain mechanisms combined lead to a colossal local strain of (2.4 ± 0.1) % and indicate coupling between oxygen octahedral tilting and polarization, here termed “rotopolarization”. These findings were confirmed with electromechanical experiments, in situ neutron diffraction, and in situ transmission electron microscopy in 0.75Bi1/2Na1/2TiO3-0.25SrTiO3. This work demonstrates that polar and non-polar instabilities can cooperate to provide colossal functional responses.

  15. Testing the dark matter scenario in the inert doublet model by future precision measurements of the Higgs boson couplings

    CERN Document Server

    Kanemura, Shinya; Sakurai, Kodai

    2016-01-01

    We evaluate radiative corrections to the Higgs boson couplings in the inert doublet model, in which the lightest component of the $Z_2^{}$ odd scalar doublet field can be a dark matter candidate. The one-loop contributions to the $hVV$, $hff$ and $hhh$ couplings are calculated in the on-shell scheme, where $h$ is the Higgs boson with the mass 125 GeV, $V$ represents a weak gauge boson and $f$ is a fermion. We investigate how the one-loop corrected Higgs boson couplings can be deviated from the predictions in the standard model under the constraints from perturbative unitarity and vacuum stability in the scenario where the model can explain current dark matter data. When the mass of the dark matter is slightly above a half of the Higgs boson mass, it would be difficult to test the model by the direct search experiments for dark matter. We find that in such a case the model can be tested at future collider experiments by either the direct search of heavier inert particles or precision measurements of the Higgs ...

  16. Surface and Interface Stress Analysis of Thin Film by X-Ray Diffraction%薄膜表面和界面应力的X射线衍射分析(中)

    Institute of Scientific and Technical Information of China (English)

    王宁; 王超群

    2011-01-01

    薄膜表面和界面应力的测量是近年来的热点课题,原则上,薄膜与体材的应力分析方法并无差别,可以通过X射线衍射进行测量.本文以有关薄膜和表面区X射线应力分析的专题评述为蓝本,解读有关依赖于试样和测量条件的分析方法和测量策略.为此,将推荐若干实用的测试方法:对于无织构和宏观弹性各向同性薄膜试样,可采用掠入射多衍射线的薄膜应力分析方法,在这种情况下,当用小入射角时,常规的sin2Ψ法可以使用;对于(hhh)和(h00)的应变测量,具有准各向同性的优点,可以直接采用sin2Ψ法;对于有织构试样,材料呈宏观弹性各向异性,可采用晶体群方法.这些方法对于薄膜、多层膜、硬质涂层或体材近表面区的应力分析,具有十分重要的理论价值和使用意义,也可用于新型电子薄膜材料等的应力分析,为其性能改善和控制提供理论依据.%The measurement of the thin film surface and interface stress is a hot subject in recent years. In principle, there is no significant difference between the stress measurement of thin film and bulk material, which can both be determined by X-ray diffraction. By reference to the literatures involving the stress measurement of thin film and surface region, various analysis methods and measurement strategies in dependence on specimen and measurement conditions, are summarized and evaluated in this research. Some practical measurement methods are commended. For macroscopically elastically isotropic and untextured specimens, the thin film stress can be analysized by grazing incident multiple X-ray diffraction method. At this condition, when the incident angle is small, conventional sin2ψ method can be applied. For (hhh) and (h00) strain measurement, due to the advantage of quasi-isotropy, the sin2ψ method can be directly used. For the textured specimen, the material is macroscopically elastically anisotropic. Crystallite group

  17. Surface and Interface Stress Analysis of Thin Film by X-Ray Diffraction%薄膜表面和界面应力的X射线衍射分析(上)

    Institute of Scientific and Technical Information of China (English)

    王宁; 王超群

    2011-01-01

    薄膜表面和界面应力的测量是近年来的热点课题,原则上,薄膜与体材的应力分析方法并无差别,可以通过X射线衍射进行测量.本文以有关薄膜和表面区X射线应力分析的专题评述为蓝本,解读有关依赖于试样和测量条件的分析方法和测量策略.为此,将推荐若干实用的测试方法:对于无织构和宏观弹性各向同性薄膜试样,可采用掠入射多衍射线的薄膜应力分析方法,在这种情况下,当用小入射角时,常规的Sin2ψ法可以使用;对于(hhh)和(h00)的应变测量,具有准各向同性的优点,可以直接采用sin2ψ法;对于有织构试样,材料呈宏观弹性各向异性,可采用晶体群方法.这些方法对于薄膜、多层膜、硬质涂层或体材近表面区的应力分析,具有十分重要的理论价值和使用意义,也可用于新型电子薄膜材料等的应力分析,为其性能改善和控制提供理论依据.%The measurement of the thin film surface and interface stress is a hot subject in recent years. In principle, there is no significant difference between the stress measurement of thin film and bulk material, which can both be determined by X-ray diffraction. By reference to the literatures involving the stress measurement of thin film and surface region, various analysis methods and measurement strategies in dependence on specimen and measurement conditions, are summarized and evaluated in this research. Some practical measurement methods are commended. For macroscopically elastically isotropic and untextured specimens, the thin film stress can be analysized by grazing incident multiple X-ray diffraction method. At this condition, when the incident angle is small, conventional sin2Ψmethod can be applied. For (hhh) and (hOO) strain measurement, due to the advantage of quasi-isotropy, the sin2Ψ method can be directly used. For the textured specimen, the material is macroscopically elastically anisotropic. Crystallite group method

  18. Effect of hypotensive fluid resuscitation on microcirculation in an uncontrolled hemorrhagic shock of pregnant rabbits%限制性输液对失血性休克孕兔微循环灌注的影响

    Institute of Scientific and Technical Information of China (English)

    秦薇; 余艳红; 王晨虹

    2010-01-01

    Objective To study the effects of hypotensive resuscitation on microvascular perfusion in a clinically relevant model of uncontrolled hemorrhagic shock in pregnancy. Methods Thirty New Zealand white rabbits at 15 -25 days, pregnanal age were randomly divided into three groups; Group normal saline traditional aggressive resuscitation ( NS), traditional aggressive resuscitation in the prehospital phase with a large quantity of normal saline and Ringer's solution to maintain mean arterial pressure (MAP) at the approximately 80 mm Hg ( 1 mm Hg = 0.133 kPa) level: Group normal saline hypotensive resuscitation (NH) and group hypertonic hyperosmotic hypotension resuscitation (HHH), hypotensive resuscitation in the prehospital phase with a bolus dose of 4 ml/kg normal saline or hypertonic hydroxyl ethyl starch (10% hydroxyl ethyl starch + 7.5% NaCl), followed by Ringer's solution to maintain MAP at 60 mm Hg.Production pregnant rabbit model with hemorrhagic shock. The experiment consisted of four phases:basic phase (0 miniutes), shock phase (0- 30 miniutes), prehospital phase (30- 90 miniutes) and hospital phase (90- 180 miniutes). Measurements: (1) arteriole and venule diameter were continuously monitored by microcirculatory detecting instrument; (2) functional capillary density (FCD) of each phase was expressed by the percentage of opening capillaries segments relative to basic phase; (3) blood pH, BE PCO2, PO2 in pregnant rabbits were determined with a Medica Easy Blood Gas Analyzer. Results ( 1 )There were no significant differences among three groups in arteriole and venule diameter at baseline ( P >0.05 ). After hemorrhagic shock arteriole diameter were NS ( 50.8 ± 5.6) μm, NH (47.6 ± 3.7 ) μm, HHH (51.3 ±2.4)μm, respectively, with no significant differences between groups(P >0.05). At the end of prehospital resuscitation phase and hospital resuscitation phase, significant differences were found in arteriole diameter in group NS(52.8 ± 4.9, 56.0 ± 3.8 )

  19. 薄膜表面和界面应力的X射线衍射分析(下)%Surface and Interface Stress Analysis of Thin Film by X-ray Diffraction

    Institute of Scientific and Technical Information of China (English)

    王宁; 王超群

    2011-01-01

    The measurement of the thin film surface and interface stress is a hot subject in recent years. In principle, there is no significant difference between the stress measurement of thin film and bulk material, which can both be determined by X-ray diffraction. By reference to the literatures involving the stress measurement of thin film and surface region, various analysis methods and measurement strategies in dependence on specimen and measurement conditions, are summarized and evaluated in this research. Some practical measurement methods are commended. For macroscopically e-lastically isotropic and untextured specimens, the thin film stress can be analysized by grazing incident multiple X-ray diffraction method. At this condition, when the incident angle is small, conventional siivty method can be applied. For (hhh) and (MX)) strain measurement, due to the advantage of quasi-isotropy, the sirn)< method can be directly used. For the textured specimen, the material is macroscopically elastically anisotropic. Crystallite group method can be applied. These methods have very important theoretical and practical value for the stress analysis of thin film, multilayer, hard coating, or near surface area of bulk material. They can also be used for the stress analysis of new electronic thin film materials, and supply theoretical basis for the control and improvement of performance.%薄膜表面和界面应力的测量是近年来的热点课题,原则上,薄膜与体材的应力分析方法并无差别,可以通过X射线衍射进行测量.本文以有关薄膜和表面区X射线应力分析的专题评述为蓝本,解读有关依赖于试样和测量条件的分析方法和测量策略.为此,将推荐若干实用的测试方法:对于无织构和宏观弹性各向同性薄膜试样,可采用掠入射多衍射线的薄膜应力分析方法,在这种情况下,当用小入射角时,常规的sin2ψ法可以使用;对于(hhh)和(h00)的应变测量,具有准各向同性

  20. Molecular characterization of NAD+-dependent DNA ligase from Wolbachia endosymbiont of lymphatic filarial parasite Brugia malayi.

    Directory of Open Access Journals (Sweden)

    Nidhi Shrivastava

    Full Text Available The lymphatic filarial parasite, Brugia malayi contains Wolbachia endobacteria that are essential for development, viability and fertility of the parasite. Therefore, wolbachial proteins have been currently seen as the potential antifilarial drug targets. NAD(+-dependent DNA ligase is characterized as a promising drug target in several organisms due to its crucial, indispensable role in DNA replication, recombination and DNA repair. We report here the cloning, expression and purification of NAD(+-dependent DNA ligase of Wolbachia endosymbiont of B. malayi (wBm-LigA for its molecular characterization. wBm-LigA has all the domains that are present in nearly all the eubacterial NAD(+-dependent DNA ligases such as N-terminal adenylation domain, OB fold, helix-hairpin-helix (HhH and BRCT domain except zinc-binding tetracysteine domain. The purified recombinant protein (683-amino acid was found to be biochemically active and was present in its native form as revealed by the circular dichroism and fluorescence spectra. The purified recombinant enzyme was able to catalyze intramolecular strand joining on a nicked DNA as well as intermolecular joining of the cohesive ends of BstEII restricted lamda DNA in an in vitro assay. The enzyme was localized in the various life-stages of B. malayi parasites by immunoblotting and high enzyme expression was observed in Wolbachia within B. malayi microfilariae and female adult parasites along the hypodermal chords and in the gravid portion as evident by the confocal microscopy. Ours is the first report on this enzyme of Wolbachia and these findings would assist in validating the antifilarial drug target potential of wBm-LigA in future studies.

  1. Classification and evolutionary history of the single-strand annealing proteins, RecT, Redβ, ERF and RAD52

    Directory of Open Access Journals (Sweden)

    Aravind L

    2002-03-01

    Full Text Available Abstract Background The DNA single-strand annealing proteins (SSAPs, such as RecT, Redβ, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. Recently, they have been shown to form similar helical quaternary superstructures. However, despite the functional similarities between these diverse SSAPs, their actual evolutionary affinities are poorly understood. Results Using sensitive computational sequence analysis, we show that the RecT and Redβ proteins, along with several other bacterial proteins, form a distinct superfamily. The ERF and Rad52 families show no direct evolutionary relationship to these proteins and define novel superfamilies of their own. We identify several previously unknown members of each of these superfamilies and also report, for the first time, bacterial and viral homologs of Rad52. Additionally, we predict the presence of aberrant HhH modules in RAD52 that are likely to be involved in DNA-binding. Using the contextual information obtained from the analysis of gene neighborhoods, we provide evidence of the interaction of the bacterial members of each of these SSAP superfamilies with a similar set of DNA repair/recombination protein. These include different nucleases or Holliday junction resolvases, the ABC ATPase SbcC and the single-strand-binding protein. We also present evidence of independent assembly of some of the predicted operons encoding SSAPs and in situ displacement of functionally similar genes. Conclusions There are three evolutionarily distinct superfamilies of SSAPs, namely the RecT/Redβ, ERF, and RAD52, that have different sequence conservation patterns and predicted folds. All these SSAPs appear to be primarily of bacteriophage origin and have been acquired by numerous phylogenetically distant cellular genomes. They generally occur in predicted operons encoding one or more of a set of conserved DNA recombination proteins that appear to be the principal functional

  2. The Rashba effect on a double-barrier spin polarizer

    Energy Technology Data Exchange (ETDEWEB)

    Makler, Sergio S. [Instituto de Fisica, Universidade Federal Fluminense, Campus da Praia Vermelha, 24210-340 Niteroi-RJ (Brazil)]. E-mail: sergio@if.uff.br; Guilherme Zelcovit, Joao [Instituto de Fisica, Universidade do Estado de Rio de Janeiro, RJ (Brazil); Boselli, Marco A. [Departamento de Fisica, Universidade Federal de Ouro Preto, MG (Brazil); Cunha Lima, Ivan C. da [Instituto de Fisica, Universidade do Estado de Rio de Janeiro, RJ (Brazil)

    2004-12-31

    The Rashba effect on a double-barrier spin polarizer is considered using a formalism that produces accurate results with little computational effort. In previous articles, we proposed a spin polarizer consisting of a well made of a dilute magnetic semiconductor (DMS) enclosed by two non-magnetic barriers. In the absence of Rashba effect, the magnetization of the well produces totally polarized electronic levels separated by 0.15eV. The highest steady magnetic field obtained in a laboratory could not produce a Zeeman splitting so big. As a consequence the calculated currents are almost totally polarized. The Rashba spin-orbit Hamiltonian produces a spin flip. Therefore, the levels at the well have not well-defined spin polarization and the currents are less polarized. The device presented here would be useful for spintronics because there are DMS ferromagnetic at room temperature. Our tight-binding Hamiltonian, including the Rashba term, isH=HK+HP+HE+HM+Hh-i+Hh-h+HR.The first term is the kinetic energy. HP describes the double-barrier profile and the third term represent the electric field due to the applied bias. The magnetic HM, the hole-impurity Hh-i and the hole-hole Hh-h terms are included in the mean field approximation. The profile and the charge distribution are calculated self-consistently.By using a decimation formalism, all these terms are treated exactly. Finally, the Rashba term HR is very small. Therefore, it is treated using second order perturbation theory. The calculation confirm that the Rashba effect on the currents is of second order. Consequently, the resulting depolarization is very small.

  3. 非综合征型遗传性耳聋基因的研究进展及相关网络资源

    Institute of Scientific and Technical Information of China (English)

    徐悦凡; 杨字

    2001-01-01

    耳聋是一种最常见的人类感觉系统缺陷,70%的遗传性耳聋属于非综合征型听力缺损。据估计非综合征型遗传性耳聋基因总数在100个以上,迄今已经有大约80个基因位点被绘制于人类染色体上.18个基因被鉴定。本文系统地介绍了已鉴定的18个非综合征型耳聋基因,这些基因分别编码两个线粒体基因12S rRNA和tRNA Set,COCH.COLllA2.DFNA5,diaphanous(D1APH),三个间隙连接蛋白(GIB2,GIB3和GJB6),钾离子通道亚基4(KCNQ4),两个非常规肌球蛋白(MY07A和MY015),Otoferlin(OTOF),pendrin(PDS),两个POU域转录因子(POU3F4和POU4F3).α-tectorin(TECTA)以及跨膜丝氨酸蛋白酶3(TMPRSS3),并列举了如遗传性听力缺损网站(Hereditary Heating Loss Homepage,Http://www uia.ac.be/dnalab/hhh)等与遗传性耳聋相关的部分网络资源以供参考。

  4. Enhancement of DNaseI Salt Tolerance by Mimicking the Domain Structure of DNase from an Extremely Halotolerant Bacterium Thioalkalivibrio sp. K90mix.

    Directory of Open Access Journals (Sweden)

    Gediminas Alzbutas

    Full Text Available In our previous work we showed that DNaseI-like protein from an extremely halotolerant bacterium Thioalkalivibrio sp. K90mix retained its activity at salt concentrations as high as 4 M NaCl and the key factor allowing this was the C-terminal DNA-binding domain, which comprised two HhH (helix-hairpin-helix motifs. The further investigations revealed that this domain originated from proteins related to bacterial competence ComEA/ComE proteins. It is likely that in the course of evolution the DNA-binding domain from these proteins was fused to a metallo-β-lactamase superfamily domain. Very likely such domain organization having proteins subsequently "donated" the DNA-binding domain to bacterial DNases. In this study we have mimicked this evolutionary step by fusing bovine DNaseI and DNA-binding domains. We have created two fusions: one harboring the DNA-binding domain of DNaseI-like protein from Thioalkalivibrio sp. K90mix and the second one harboring the DNA-binding domain of bacterial competence protein ComEA from Bacillus subtilis. Both domains enhanced salt tolerance of DNaseI, albeit to different extent. Molecular modeling revealed the essential differences between their interaction with DNA shedding some light on the differences in salt tolerance. In this study we have enhanced salt tolerance of bovine DNaseI; thus, we successfully mimicked the Nature's evolutionary engineering that created the extremely halotolerant bacterial DNase. We have demonstrated that the newly engineered DNaseI variants can be successfully used in applications where activity of the wild type bovine DNaseI is impeded by buffers used.

  5. Enhancement of DNaseI Salt Tolerance by Mimicking the Domain Structure of DNase from an Extremely Halotolerant Bacterium Thioalkalivibrio sp. K90mix

    Science.gov (United States)

    Alzbutas, Gediminas; Kaniusaite, Milda; Lagunavicius, Arunas

    2016-01-01

    In our previous work we showed that DNaseI-like protein from an extremely halotolerant bacterium Thioalkalivibrio sp. K90mix retained its activity at salt concentrations as high as 4 M NaCl and the key factor allowing this was the C-terminal DNA-binding domain, which comprised two HhH (helix-hairpin-helix) motifs. The further investigations revealed that this domain originated from proteins related to bacterial competence ComEA/ComE proteins. It is likely that in the course of evolution the DNA-binding domain from these proteins was fused to a metallo-β-lactamase superfamily domain. Very likely such domain organization having proteins subsequently “donated” the DNA-binding domain to bacterial DNases. In this study we have mimicked this evolutionary step by fusing bovine DNaseI and DNA-binding domains. We have created two fusions: one harboring the DNA-binding domain of DNaseI-like protein from Thioalkalivibrio sp. K90mix and the second one harboring the DNA-binding domain of bacterial competence protein ComEA from Bacillus subtilis. Both domains enhanced salt tolerance of DNaseI, albeit to different extent. Molecular modeling revealed the essential differences between their interaction with DNA shedding some light on the differences in salt tolerance. In this study we have enhanced salt tolerance of bovine DNaseI; thus, we successfully mimicked the Nature’s evolutionary engineering that created the extremely halotolerant bacterial DNase. We have demonstrated that the newly engineered DNaseI variants can be successfully used in applications where activity of the wild type bovine DNaseI is impeded by buffers used. PMID:26939122

  6. 黄淮海地区植被生长季变化及其气候变化响应%The Change of Growing Season of the Vegetation in Huanghe-Huaihe-Haihe Region and Its Responses to Climate Changes

    Institute of Scientific and Technical Information of China (English)

    陈怀亮; 刘玉洁; 杜子璇; 刘忠阳; 邹春辉

    2011-01-01

    Using the each ten-day data of NOAA/AVHRR from 1981 to 2000 and adopting the Maximum-Slope method, Curve-Fitting method and stepwise regression, the beginning and ending of the growth season of the vegetations in the Huanghe-Huaihe-Haihe (HHH) region are analyzed. Meanwhile, the pixel by pixel JNDv map is worked out with typical bands as the sample. Through analyzing the change of green wave and brown wave, the changing rules of vegetation activities and its responses to climate changes in the past 20 years are revealed. The growth season in HHH region starts at the last 10 days of March with /Ndv0. 19604 and ends at the first 10 days of November with INDV 0. 22899 on average. The tendency is that the growing season has prolonged obviously by starting earlier and earlier, while ending later and later from 1982 to 2000. The average Indv for the vegetation in the researched area in the past 20 years is generally increasing, especially in spring. According to the Indv map of typical bands as the sample worked out with the pixel by pixel, the green wave changes from south to north during January-July on the band of 116°E, the maximum of Indv occurs in August and decreases gradually after September. On the band of 36°N, to the east and nearby 116°E , the Indv has two peaks because of two crops a year, which is obviously different from other regions. The two peaks occur in April and August and they become clearer and clearer from 1982 to 2000, especially in agriculture area. However, the two peaks are not obvious to the north of 38. 5°N, in the area of Beijing, Tianjin and the mountain areas, and the peak value of early summer is lower than that of autumn. In agriculture area, the peak interval of green wave is broadening with the time passing by, and it's more obviously from south to north. With the time passing by, the green wave of the critical value of the growth season in the area changes from south to north, while the emergence of brown wave prolongs from north

  7. Trends in extreme temperature indices in Huang-Huai-Hai River Basin of China during 1961-2014

    Science.gov (United States)

    Wang, Gang; Yan, Denghua; He, Xiaoyan; Liu, Shaohua; Zhang, Cheng; Xing, Ziqiang; Kan, Guangyuan; Qin, Tianling; Ren, Minglei; Li, Hui

    2017-08-01

    Spatial and temporal characteristics of temperature extremes have been investigated in Huang-Huai-Hai (HHH) region based on the daily series of temperature observations from 162 meteorological stations. A total of 11 indices were used to assess the changes of temperature pattern. Linear trend analyses revealed that the daily maximum temperature (TXx) increased at α = 0.05 level with a magnitude of 0.15 °C per decade on the regional scale during the period of 1961-2014. More pronounced warming trend of the daily minimum temperature (TNn) was detected at a rate of 0.49 °C per decade (α = 0.01 level). Consequently, a decreasing trend of the temperature range of TXx and TNn (extreme temperature range) was observed. The frequency of hot days (TXf90) and annual average of warm events (warm spell duration indicator, WSDI) showed significant increasing trends, while that of cold nights (TNf10) and cold events (cold spell duration indicator, CSDI) showed opposite behaviors. Both warm winter (W-W) and hot summer (H-S) series displayed significant increasing trends at α = 0.01 confidence level. The cold winter (C-W) series showed a decreasing trend at α = 0.01 confidence level, while the cool summer (C-S) series showed a nonsignificant decreasing trend that is not passing the 90% confidence level (α = 0.1). Abrupt increments of warm­related extremes (TXx, TXf90, WSDI) have been detected since 1990s, and a steadily decreasing trend of cold related extremes (TNf10, CSDI) was found since 1970s. Ten hot summers out of 11 and nine warm winters out of 10 occurred after 1990s. Altitude has a large impact on spatial pattern of extreme temperature indices, and the urban heat island effect also has an impact on amplitude of variation in extreme temperature. Trend magnitudes are significantly larger at sites with high altitudes for warm­related indices (TXx, TXf90, WSDI), while those involving cold-related indices (TNn, TNf10) are remarkably larger for stations with low

  8. 出口食品农产品检验检疫风险评价体系的建立%The Establishment of Risk Assessment System for Inspection and Quarantine of Food and Agricultural Exports

    Institute of Scientific and Technical Information of China (English)

    陈孟裕; 高保立; 毛唯君; 梁启平; 翁志平

    2011-01-01

    The Inspection and Quarantine Risk Assessment Matrix(IQRAM) for export food and agricultural products were constructed with the principles and methods of U.S.MIL-STD-822B standard.For the first time,the Inspection and Quarantine Risk Accident(IQRA) was defined as the adverse reactions caused by substandard product at home or abroad.The IQRA severe grading standards were established,and the probability of IQRA was estimated by the frequency of the IQRA occurring within a year in the paper.The monitoring program of food and agricultural exports was developed with 459 batches of samples,according to EU Directive 2002/63/EC.Based on risk evaluation system,the risk of inspection and quarantine of export food and agricultural products is set to five levels,such as HHH,HH,H,M and L.The specific risk level of exported companies or products could be dynamically adjusted to tightening or loosening according to the monitoring results.%利用美国M IL-STD-822B标准的原理和方法构建了出口食品农产品检验检疫风险评价矩阵,首次定义了检验检疫风险事故是不合格产品引起的国内外不良反应,并制定了风险事故后果的严重等级划分标准,确立了以一年内发生风险事故的频次作为风险事故发生概率的原则;同时依据欧盟2002/63/EC指令对风险评价结果制定了以连续459批为一个监控周期的抽样方案。根据风险评价体系,将出口食品农产品检验检疫风险设置为5个风险等级:HHH、HH、H、M和L,依据监控抽样的检测结果可以对具体出口企业和产品进行风险等级加严或放宽的动态调节。

  9. Oxygen isotope and petrological study of silicate inclusions in IIE iron meteorites and their relationship with H chondrites

    Science.gov (United States)

    McDermott, Kathryn H.; Greenwood, Richard C.; Scott, Edward R. D.; Franchi, Ian A.; Anand, Mahesh

    2016-01-01

    The origin of silicate-bearing irons, especially those in groups IAB, IIICD, and IIE, is poorly understood as silicate should have separated rapidly from molten metal. Here we report the results of high precision oxygen isotope analysis of silicate inclusions in eleven group IIE meteorites and a petrological study of silicate inclusions in ten IIE irons including those in Garhi Yasin and Tarahumara, which have not been described in detail before. Oxygen isotopes have also been analysed in 20 H chondrites to investigate their possible relationship with the IIE irons. Based on petrographic observations and mineral analysis, the silicate-bearing IIE meteorites have been divided into four types according to the nature of their silicate inclusions: (1) primitive chondritic, (2) evolved chondritic, (3) differentiated with >10 vol.% orthopyroxene, and (4) differentiated with source for Colomera is deemed unlikely. Three IIE irons with primitive chondritic inclusions, Garhi Yasin, Netschaëvo, and Techado, have relatively low mean Δ17O values of 0.56-0.57‰ as well as relatively reduced silicates with Fa15-17 olivine, which have been called HH chondrites. Given the significant overlap in their oxygen isotope compositions, a genetic relationship between IIE irons and H chondrites is supported by our new data. However, derivation of both groups from one parent body seems unlikely. Instead, both groups probably sampled similar precursor materials and accreted at a similar nebular location. Our data suggest that the IIE meteorites formed on an internally heated H/HH chondrite-like body that experienced the initial stages of differentiation in response to radiogenic heating. However, prior to full differentiation the IIE parent body experienced a major hit-and-run style collision that resulted in silicate-metal mixing. The initial stages of this event involved a phase of rapid cooling that prevented unmixing of metal and silicates. Reassembly of the IIE parent body produced a

  10. Innovations in tourism marketing: Operation Anthropoid in Prague

    Directory of Open Access Journals (Sweden)

    W. Strielkowski

    2016-12-01

    Operation Daybreak” or from the book “HHhH” by the French writer and historian Laurent Binet. Moreover, our results show that the potential smartphone and tablet app should contain an opening introductory video about the Operation Anthropoid, an interactive map, facts & details augmented reality photos, a quest with a possibility to collect points or play against other users, as well as the information on the Prague transportation and the possibility to buy tickets online. The app should be offered free of charge, as a so-called “light version” with a possibility to buy the full version, or should be offered for free download at App Store or Google Market with an option to send a donation to its creators. Conclusions and directions for further research. Our results might lead to the successful creation and implementation of the geolocation game which became very popular recently due to the breath-taking success of the “Pokemon Go” game worldwide. As for the pathways for further research, an analysis of attributes and other features of potential app might be also tested using a conjoint analysis approach or revealed preferences techniques. Some more research can be done on eliciting the willingness-to-pay (WTP for the potential app-like game.

  11. Neural Differentiation of Human Umbilical Cord Mesenchymal Stem Cells by Cerebrospinal Fluid

    Directory of Open Access Journals (Sweden)

    Shirin FARIVAR*

    2015-01-01

    chick embryos. J Exp Zool A Comp Exp Biol 2004 Apr 1;301(4:280-9.Mitchell KE, Weiss ML. Matrix cells from Wharton’s jelly form neurons and glia. Stem Cells 2003;21(1:50-60.Marcus AJ, Woodbury D. Fetal stem cells from extra-embryonic tissues: do not discard. J Cell Mol Med 2008 Jun;12(3:730-42. doi: 10.1111/j.1582- 4934.2008.00221.x. Epub 2008 Jan 11.Miao Z, Jin J, Chen L, Zhu J, Huang W, Zhao J, Quian H, Zhang X. Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells. Cell Biol Int 2006 Sep;30(9:681-7. Epub 2006 Apr 22.In ‘tAnker PS, Scherjon SA, Kleijburg-van der Keur C, Noort WA, Claas FHJ, Willemze R, Fibbe WE, Kanhai HHH. Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation. Blood 2003;102(4:1548-49.Magatti M, De Munari S, Vertua E, Gibelli L, Wengler GS, Parolini O. Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities. Stem Cells 2008 Jan;26(1:182-92. Epub 2007 Sep 27.Kang XQ, Zang WJ, Bao LJ, Li DL, Xu XL, Yu XJ. Differentiating characterization of human umbilical cord blood-derived mesenchymal stem cells in vitro. Cell Biol Int 2006 Jul;30(7:569-75. Epub 2006 Mar 6.Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006 May;24(5:1294-301. Epub 2006 Jan 12.Wagner W, Wein F, Seckinger A, Frankhauser M, Wirkner U, Krause U, et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 2005 Nov;33(11:1402-16.Jackson JS, Golding JP, Chapon C, Jones WA, Bhakoo KK: Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study. Stem Cell Res Ther 2010 Jun 15;1(2:17. doi: 10.1186/scrt17.Romanov YA, Svintsitskaya VA, Smirnov VN. Searching for alternative