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Sample records for hhh hhh ddd

  1. What if $\\lambda_{hhh}\

    CERN Document Server

    Efrati, Aielet

    2014-01-01

    A measurement of the Higgs trilinear self coupling $\\lambda_{hhh}$ will test the Standard Model Higgs potential. But can it reveal information that cannot be learned otherwise? By analyzing several simple extensions of the Standard Model scalar sector we show that this measurement might give a first hint for New Physics modifying the electroweak symmetry breaking. Combining the measurements of $\\lambda_{hhh}$ and $\\lambda_{hVV}$ ($V=W,Z$) is particularly powerful in distinguishing between various models of New Physics and in providing unique information on these models.

  2. 40 CFR Appendix: Table 1 to... - List of Hazardous Air Pollutants (HAP) for Subpart HHH

    Science.gov (United States)

    2010-07-01

    ...) for Subpart HHH Table Appendix: Table 1 to Subpart HHH of Part 63 Protection of Environment... Natural Gas Transmission and Storage Facilities Pt. 63, Subpt. HHH, Table 1 Appendix: Table 1 to Subpart HHH of Part 63—List of Hazardous Air Pollutants (HAP) for Subpart HHH CAS Number a Chemical name...

  3. hhh Coupling in SUSY models after LHC run I

    CERN Document Server

    Wu, Lei; Yuan, Chien-Peng; Zhang, Mengchao

    2015-01-01

    We examine the Higgs triple coupling in MSSM and NMSSM under current constraints, which include the LHC measurements, Higgs data, B physics, electroweak precision observables, relic density and so on. The ratio $\\lambda^{\\rm MSSM}_{hhh}/\\lambda^{\\rm SM}_{hhh}$ is above 0.97, due to the highly constrained parameter space. While the ratio $\\lambda^{\\rm NMSSM}_{hhh}/\\lambda^{\\rm SM}_{hhh}$ can reach 0.1 under current constraints. The precise measurement in future collider will give a tighter constraint to the Higgs triple coupling in MSSM and NMSSM.

  4. 40 CFR Table 2 to Subpart Hhh of... - Toxic Equivalency Factors

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Toxic Equivalency Factors 2 Table 2 to Subpart HHH of Part 62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS..., Subpt. HHH, Table 2 Table 2 to Subpart HHH of Part 62—Toxic Equivalency Factors Dioxin/furan...

  5. Tests of Higgs boson compositeness through the HHH form factor

    CERN Document Server

    Gounaris, G J

    2015-01-01

    We show how the $q^2$-dependence of the triple Higgs boson HHH form factor can reveal the presence of various types of new physics contributions, like new particles coupled to the Higgs boson or Higgs boson constituents, without directly observing them. We compare the effect of such new contributions to the one of higher order SM corrections to the point-like HHH coupling, due to triangle, 4-leg and s.e. diagrams. We establish simple analytic expressions describing accurately at high energy these SM corrections, as well as the examples of new physics contributions.

  6. 40 CFR Appendix: Table 2 to... - Applicability of 40 CFR Part 63 General Provisions to Subpart HHH

    Science.gov (United States)

    2010-07-01

    ... HHH of Part 63—Applicability of 40 CFR Part 63 General Provisions to Subpart HHH General provisions... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Applicability of 40 CFR Part 63 General Provisions to Subpart HHH Table Appendix: Table 2 to Subpart HHH of Part 63 Protection of...

  7. [Molecular genetic studies of mitochondrial ornithine transporter deficiency (HHH syndrome)].

    Science.gov (United States)

    Tsujino, S; Miyamoto, T; Kanazawa, N

    2001-11-01

    Mitochondrial ornithine transporter deficiency has been called HHH syndrome, because this disorder is characterized by three biochemical abnormalities; hyperornithinemia, hyperammonemia, and homocitrullinuria, and presents with various neurological symptoms; mental retardation, spastic paraparesis with pyramidal signs, cerebellar ataxia and episodic disturbance of consciousness or coma due to hyperammonemia. We identified four mutations in the mitochondrial ornithine transporter gene (ORNT1) of Japanese patients with HHH syndrome. These include a nonsense mutation (R179X), associated with exon skipping, missense mutations (G27E, P126R), and an insertion of AAC between codons 228 and 229, leading to an insertion of amino acid Asn. Especially, R179X was detected 4 of 7 Japanese patients (8 of 14 alleles), implying that this is a common mutation in Japanese population.

  8. 40 CFR Appendix A to Subpart Hhh... - Exempted Aquifers in New Mexico

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Exempted Aquifers in New Mexico A Appendix A to Subpart HHH of Part 147 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Appendix A to Subpart HHH of Part 147—Exempted Aquifers in New Mexico The areas described by a...

  9. 40 CFR Table 1 to Subpart Hhh of... - Emission Limits for Small Rural, Small, Medium, and Large HMIWI

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Emission Limits for Small Rural, Small, Medium, and Large HMIWI 1 Table 1 to Subpart HHH of Part 62 Protection of Environment ENVIRONMENTAL... Incinerators Constructed on or Before June 20, 1996 Pt. 62, Subpt. HHH, Table 1 Table 1 to Subpart HHH of...

  10. Abnormal urinary excretion of polyamines in HHH syndrome (hyperornithinemia associated with hyperammonemia and homocitrullinuria).

    Science.gov (United States)

    Shimizu, H; Maekawa, K; Eto, Y

    1990-01-01

    The HHH syndrome (hyperornithinemia associated with hyperammonemia and homocitrullinuria) is characterized by a very rare genetic defect of ornithine transport in mitochondrial membrane. We first demonstrated that a patient with HHH syndrome excreted about 6 times higher amount of polyamines in urine than the control when supplemented with high protein diets and ornithine loading. Each urinary polyamine fraction measured by HPLC method in HHH syndrome appears to be increased, as compared with those of the control. These data suggest that increased urinary excretion of polyamines in this syndrome is closely related to overflowing of plasma polyamine due to an ornithine transport defect in the mitochondrial membrane.

  11. Diagnosis and high incidence of hyperornithinemia-hyperammonemia-homocitrullinemia (HHH) syndrome in northern Saskatchewan.

    Science.gov (United States)

    Sokoro, AbdulRazaq A H; Lepage, Joyce; Antonishyn, Nick; McDonald, Ryan; Rockman-Greenberg, Cheryl; Irvine, James; Lehotay, Denis C

    2010-12-01

    Mutations in the SLC25A15 gene, encoding the human inner mitochondrial membrane ornithine transporter, are thought to be responsible for hyperornithinemia-hyperammonemia-homocitrullinemia (HHH) syndrome, a rare autosomal recessive condition. HHH syndrome has been detected in several small, isolated communities in northern Saskatchewan (SK). To determine the incidence of HHH syndrome in these communities, a PCR method was set up to detect F188Δ, the common French-Canadian mutation. Neonatal blood spots collected from all newborns from the high risk area were genotyped for the F188Δ mutation for seven consecutive years. Using DNA analysis, we estimated that the heterozygote frequency for the mutant allele for HHH syndrome to be about 1 in 19 individuals, predicting one affected child with HHH syndrome for approximately every 1,500 individuals (1 in 1,550 live births; 1 child every 12 years) in this isolated population. The frequency for the mutant allele for HHH syndrome in this isolated community is probably the highest in the world for this rare disorder. We determined that ornithine levels, by tandem mass spectrometry, were not abnormal in newborns with F188Δ mutation, carriers and normals. Ornithine rises to abnormally high levels at some time after birth well past the time that the newborn screening blood spot is collected. The timing or the reasons for the delayed rise of ornithine in affected children with HHH syndrome have not been determined. Newborn screening for HHH Syndrome in this high risk population is only possible by detection of the mutant allele using DNA analysis.

  12. Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH) presenting with acute fulminant hepatic failure.

    Science.gov (United States)

    Mhanni, A A; Chan, A; Collison, M; Seifert, B; Lehotay, D C; Sokoro, Ah; Huynh, H Q; Greenberg, C R

    2008-03-01

    We report on two Aboriginal patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. Both presented with acute hepatic failure with severe hypertransaminasemia and coagulopathy, prompting evaluation for emergent liver transplantation. The diagnosis of HHH syndrome was based on the presence of typical metabolic abnormalities. A protein-restricted diet and L-arginine or L-citrulline supplementation were immediately started, with rapid normalization of liver function test results and other biochemical abnormalities. Molecular analysis of the SLC25A15 gene showed that the two patients were homozygous for the common French Canadian mutation (F188Delta). The diagnosis of HHH syndrome should be considered in patients with unexplained fulminant hepatic failure. There does not appear to be a genotype-phenotype correlation for this presentation, inasmuch as the only other reported patient presenting with this picture had two different point mutations. Early identification and prompt treatment of these patients is crucial to avoid liver transplantation and can be life saving.

  13. HHH syndrome (hyperornithinaemia, hyperammonaemia, homocitrullinuria), with fulminant hepatitis-like presentation.

    Science.gov (United States)

    Fecarotta, S; Parenti, G; Vajro, P; Zuppaldi, A; Della Casa, R; Carbone, M T; Correra, A; Torre, G; Riva, S; Dionisi-Vici, C; Santorelli, F M; Andria, G

    2006-02-01

    We report a 3-year-old Italian patient with the hyperornithinaemia, hyperammonaemia, homocitrullinuria (HHH) syndrome who presented with neurological deterioration after an intercurrent infection. Hyperammonaemia, coagulopathy and moderate hypertransaminasaemia were detected on hospital admission. Severe hepatocellular necrosis with hypertransaminasaemia (aspartate aminotransferase 20,000 UI/L, alanine aminotransferase 18,400 UI/L) and coagulopathy (PT HHH syndrome was based on the presence of the typical metabolic abnormalities. Molecular analysis of the SLC25A15 gene showed that the patient was heterozygous for two novel mutations (G113C and M273K). The diagnosis of HHH syndrome should be considered in patients with fulminant hepatitis-like presentations. Early identification and treatment of these patients can be life-saving and can avoid liver transplantation.

  14. Ultrastructural changes in fibroblast mitochondria of a patient with HHH-syndrome.

    Science.gov (United States)

    Metoki, K; Hommes, F A; Dyken, P; Kelloes, C; Trefz, J

    1984-01-01

    Electron micrographs of fibroblasts of an HHH-syndrome patient showed abnormal structures, similar, but not identical, to those observed in the liver of such patients. It is suggested that incorporation of a mutated protein into the inner mitochondrial membrane gives rise to a rearrangement of that membrane, resulting in unusual structures.

  15. The HhH domain of the human DNA repair protein XPF forms stable homodimers.

    Science.gov (United States)

    Das, Devashish; Tripsianes, Konstantinos; Jaspers, Nicolaas G J; Hoeijmakers, Jan H J; Kaptein, Robert; Boelens, Rolf; Folkers, Gert E

    2008-03-01

    The human XPF-ERCC1 protein complex plays an essential role in nucleotide excision repair by catalysing positioned nicking of a DNA strand at the 5' side of the damage. We have recently solved the structure of the heterodimeric complex of the C-terminal domains of XPF and ERCC1 (Tripsianes et al., Structure 2005;13:1849-1858). We found that this complex comprises a pseudo twofold symmetry axis and that the helix-hairpin-helix motif of ERCC1 is required for DNA binding, whereas the corresponding domain of XPF is functioning as a scaffold for complex formation with ERCC1. Despite the functional importance of heterodimerization, the C-terminal domain of XPF can also form homodimers in vitro. We here compare the stabilities of homodimeric and heterodimeric complexes of the C-terminal domains of XPF and ERCC1. The higher stability of the XPF HhH complexes under various experimental conditions, determined using CD and NMR spectroscopy and mass spectrometry, is well explained by the structural differences that exist between the HhH domains of the two complexes. The XPF HhH homodimer has a larger interaction interface, aromatic stacking interactions, and additional hydrogen bond contacts as compared to the XPF/ERCC1 HhH complex, which accounts for its higher stability.

  16. A novel mutation, P126R, in a Japanese patient with HHH syndrome.

    Science.gov (United States)

    Miyamoto, Takeshi; Kanazawa, Naomi; Hayakawa, Chiemi; Tsujino, Seiichi

    2002-01-01

    Mitochondrial ornithine transporter deficiency, or HHH syndrome, is a metabolic disorder resulting in various neurologic symptoms, including mental retardation, spastic paraparesis with pyramidal signs, cerebellar ataxia, and episodic disturbance of consciousness or coma caused by hyperammonemia. Several mutations have been reported in the ORNT1 gene encoding mitochondrial ornithine transporter of patients with this disorder. In this article, we report a new patient, a male 15 years of age, who had typical clinical features of HHH syndrome. Because the patient did not have any of the three mutations previously described in other Japanese patients with HHH syndrome, and the only material available from the patient was peripheral leukocytes, we established a genomic polymerase chain reaction method using intronic primers to amplify every exon of the ORNT1 gene, and we directly sequenced the polymerase chain reaction products. Using this method, we documented a novel mutation in this patient, P126R, and demonstrated that HHH syndrome is genetically heterogeneous, even in the Japanese population.

  17. Clinical and functional characterization of a human ORNT1 mutation (T32R) in the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome.

    Science.gov (United States)

    Camacho, José A; Mardach, Rebecca; Rioseco-Camacho, Natalia; Ruiz-Pesini, Eduardo; Derbeneva, Olga; Andrade, Dario; Zaldivar, Frank; Qu, Yong; Cederbaum, Stephen D

    2006-10-01

    We studied two related families (HHH013 and HHH015) with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, a disorder of the urea cycle and ornithine degradation pathway, who have the same novel ornithine transporter (ORNT1) genotype (T32R) but a variable phenotype. Both HHH015 patients are doing well in school and are clinically stable; conversely, the three affected HHH013 siblings had academic difficulties and one suffered recurrent episodes of hyperammonemia and ultimately died. Overexpression studies revealed that the product of the ORNT1-T32R allele has residual function. Ornithine transport studies in HHH015 fibroblasts, however, showed basal activity similar to fibroblasts carrying nonfunctional ORNT1 alleles. We also examined two potential modifying factors, the ORNT2 gene and the mitochondrial DNA lineage (haplogroup). Haplogroups, associated with specific diseases, are hypothesized to influence mitochondrial function. Results demonstrated that both HHH015 patients are heterozygous for an ORNT2 gain of function polymorphism and belong to haplogroup A whereas the HHH013 siblings carry the wild-type ORNT2 and are haplogroup H. These observations suggest that the ORNT1 genotype cannot predict the phenotype of HHH patients. The reason for the phenotypic variability is unknown, but factors such as redundant transporters and mitochondrial lineage may contribute to the neuropathophysiology of HHH patients.

  18. Conscientious metabolic monitoring on a patient with hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome undergoing anaesthesia.

    Science.gov (United States)

    Mühling, J; Dehne, M G; Fuchs, M; Sablotzki, A; Weiss, S; Spatz, J; Hempelmann, G

    2001-01-01

    Currently we know not more than 50 patients who show an interesting combination of increased plasma ornithine concentrations, postprandial hyperammonemia, and homocitrullinuria (HHH-syndrome). Since exact knowledge of this severe, although rare syndrome is important for any perioperative or intensive medical treatment concerning therapy and progression of the disease, we report a comprehensive study on a 32-year old woman with this rare multifaceted disorder who had to undergo general anaesthesia. For the first time amino acid status in plasma, urine, cerebrospinal fluid and especially polymorphonuclear leucocytes, which in the investigation showed to be valuable tool for evaluating amino acid metabolism in nucleated cells in HHH-syndrome, and further important pathophysiologic indicators of cellular and metabolic function have been conscientiously investigated and compared. The pathophysiological repercussions of our results as well as the recommendations for conscientious therapeutical management are discussed.

  19. Ciliated cultured dermal fibroblasts in a patient with hyperornithinemia, hyperammonemia and homocitrullinuria (HHH) syndrome.

    Science.gov (United States)

    Haust, M D

    1995-10-01

    Hyperornithinemia, hyperammonemia and homocitrullinuria (HHH)-syndrome is a rare autosomal recessive disorder of the urea cycle, probably caused by a defect in ornithine transport across the hepatic inner mitochondrial membrane. Single rudimentary cilia were present in approximately ten percent of post-divisional or dividing fibroblasts cultured from the skin of a patient with the HHH-syndrome, whereas no such organelles were observed in dermal fibroblasts cultured from normal controls. Since single rudimentary ("primary," "oligo," "solitary") cilia have been observed in a variety of cells in animals and men but the stimuli for their formation and their significance remain controversial, a brief report on their presence in the as yet unreported condition (HHH-syndrome) was considered of interest; hopefully, it might contribute to the ultimate unravelling of some of the unresolved problems. It is of note that unlike the author's previous findings of these unusual organelles in cells affected by a pathological process (atherosclerosis), the rudimentary cilia were observed in the present instance in dividing or postdivisional cells. The implications of these (and other) observations must await further work.

  20. Diagnosis of Japanese patients with HHH syndrome by molecular genetic analysis: a common mutation, R179X.

    Science.gov (United States)

    Miyamoto, T; Kanazawa, N; Kato, S; Kawakami, M; Inoue, Y; Kuhara, T; Inoue, T; Takeshita, K; Tsujino, S

    2001-01-01

    Patients with mitochondrial ornithine transporter deficiency (or HHH syndrome) present with various neurological symptoms, including mental retardation, spastic paraparesis with pyramidal signs, cerebellar ataxia, and episodic disturbance of consciousness or coma due to hyperammonemia. We previously described three novel mutations in the ORNT1 gene in Japanese patients with HHH syndrome. In this article, we report a new patient with HHH syndrome, a 52-year-old woman, who had the typical clinical features, except for an absence of mental retardation. When we screened this patient, as well as a previously described Japanese patient, for mutations in the ORNT1 gene, we found that both were homozygous for a nonsense mutation (R179X). Furthermore, reverse transcription (RT)-polymerase chain reaction (PCR) of fibroblast RNA from one patient showed exon 4 skipping, as had been observed in a previously reported patient with R179X. These results, together with the findings in our previous report, show that, in three of our five reported Japanese HHH patients (six of ten alleles), R179X is present, suggesting that this is a common mutation in Japanese patients with HHH syndrome.

  1. Insights into the mutation-induced HHH syndrome from modeling human mitochondrial ornithine transporter-1.

    Directory of Open Access Journals (Sweden)

    Jing-Fang Wang

    Full Text Available Human mitochondrial ornithine transporter-1 is reported in coupling with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH syndrome, which is a rare autosomal recessive disorder. For in-depth understanding of the molecular mechanism of the disease, it is crucially important to acquire the 3D structure of human mitochondrial ornithine transporter-1. Since no such structure is available in the current protein structure database, we have developed it via computational approaches based on the recent NMR structure of human mitochondrial uncoupling protein (Berardi MJ, Chou JJ, et al. Nature 2011, 476:109-113. Subsequently, we docked the ligand L-ornithine into the computational structure to search for the favorable binding mode. It was observed that the binding interaction for the most favorable binding mode is featured by six remarkable hydrogen bonds between the receptor and ligand, and that the most favorable binding mode shared the same ligand-binding site with most of the homologous mitochondrial carriers from different organisms, implying that the ligand-binding sites are quite conservative in the mitochondrial carriers family although their sequences similarity is very low with 20% or so. Moreover, according to our structural analysis, the relationship between the disease-causing mutations of human mitochondrial ornithine transporter-1 and the HHH syndrome can be classified into the following three categories: (i the mutation occurs in the pseudo-repeat regions so as to change the region of the protein closer to the mitochondrial matrix; (ii the mutation is directly affecting the substrate binding pocket so as to reduce the substrate binding affinity; (iii the mutation is located in the structural region closer to the intermembrane space that can significantly break the salt bridge networks of the protein. These findings may provide useful insights for in-depth understanding of the molecular mechanism of the HHH syndrome and

  2. Insights into the mutation-induced HHH syndrome from modeling human mitochondrial ornithine transporter-1.

    Science.gov (United States)

    Wang, Jing-Fang; Chou, Kuo-Chen

    2012-01-01

    Human mitochondrial ornithine transporter-1 is reported in coupling with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, which is a rare autosomal recessive disorder. For in-depth understanding of the molecular mechanism of the disease, it is crucially important to acquire the 3D structure of human mitochondrial ornithine transporter-1. Since no such structure is available in the current protein structure database, we have developed it via computational approaches based on the recent NMR structure of human mitochondrial uncoupling protein (Berardi MJ, Chou JJ, et al. Nature 2011, 476:109-113). Subsequently, we docked the ligand L-ornithine into the computational structure to search for the favorable binding mode. It was observed that the binding interaction for the most favorable binding mode is featured by six remarkable hydrogen bonds between the receptor and ligand, and that the most favorable binding mode shared the same ligand-binding site with most of the homologous mitochondrial carriers from different organisms, implying that the ligand-binding sites are quite conservative in the mitochondrial carriers family although their sequences similarity is very low with 20% or so. Moreover, according to our structural analysis, the relationship between the disease-causing mutations of human mitochondrial ornithine transporter-1 and the HHH syndrome can be classified into the following three categories: (i) the mutation occurs in the pseudo-repeat regions so as to change the region of the protein closer to the mitochondrial matrix; (ii) the mutation is directly affecting the substrate binding pocket so as to reduce the substrate binding affinity; (iii) the mutation is located in the structural region closer to the intermembrane space that can significantly break the salt bridge networks of the protein. These findings may provide useful insights for in-depth understanding of the molecular mechanism of the HHH syndrome and developing effective

  3. Studies on a case of HHH-syndrome (hyperammonemia, hyperornithinemia, homocitrullinuria).

    Science.gov (United States)

    Hommes, F A; Roesel, R A; Metoki, K; Hartlage, P L; Dyken, P R

    1986-02-01

    A patient with the hyperornithinemia, hyperammonemia, homocitrullinuria syndrome is described. This patient represents the 12th documented case of this rare, presumably autosomal recessive condition. Increased levels of ammonia, ornithine and homocitrulline were demonstrated in blood and cerebrospinal fluid. The blood ammonia concentration could be lowered by supplementation of the diet with low doses of arginine. High doses of arginine precipitated seizures, although plasma levels of arginine and ornithine were not altered. The uptake of ornithine by the particulate fraction of the patient's fibroblasts was lower than that of controls, but still measurable. It is suggested that HHH patients have a partial impairment of the uptake of ornithine by mitochondria.

  4. Determination of homocitrulline in urine of patients with HHH syndrome by liquid chromatography tandem mass spectrometry.

    Science.gov (United States)

    Al-Dirbashi, Osama Y; Al-Hassnan, Zuhair N; Rashed, Mohamed S

    2006-12-01

    A liquid chromatography tandem mass spectrometric method is described for the analysis of homocitrulline in human urine, a key metabolite in the differential diagnosis of hyperammonemia, hyperornithinemia, homocitrullinuria (HHH) syndrome. Urine samples were prepared by mere five-fold dilution with a mixture of internal standards (2H2-citrulline and 2H3-creatinine) used for the simultaneous quantification of creatinine. Analytes were separated on a cyano column and eluted isocratically within seven min. Detection was achieved by monitoring transitions of 190 > 84 and 190 > 127 for homocitrulline, 178 > 115 for 2H2-citrulline, 114 > 44 for creatinine and 117 > 47 for 2H3-creatinine. Calibration curves were linear up to 100 micromol/L. Intraday (n = 7) and interday (n = 6) variations were less than 10%. In urine samples from three siblings confirmed to have HHH syndrome, homocitrulline levels were at 13.3 (74), 21.1 (50) and 108.2 (103) mmol/mol creatinine (micromol/L). Control values were 0-9 mmol/mol creatinine (n = 120). The current method solves specificity issues in homocitrulline determination often encountered with some ninhydrin-based systems (coelution with methionine) and some o-phthalaldehyde-based ones (coelution with taurine), and presents an attractive alternative with a relatively high throughput.

  5. Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase.

    Science.gov (United States)

    Wang, Li Kai; Nair, Pravin A; Shuman, Stewart

    2008-08-22

    NAD(+)-dependent DNA ligases (LigAs) are ubiquitous in bacteria and essential for growth. LigA enzymes have a modular structure in which a central catalytic core composed of nucleotidyltransferase and oligonucleotide-binding (OB) domains is linked via a tetracysteine zinc finger to distal helix-hairpin-helix (HhH) and BRCT (BRCA1-like C-terminal) domains. The OB and HhH domains contribute prominently to the protein clamp formed by LigA around nicked duplex DNA. Here we conducted a structure-function analysis of the OB and HhH domains of Escherichia coli LigA by alanine scanning and conservative substitutions, entailing 43 mutations at 22 amino acids. We thereby identified essential functional groups in the OB domain that engage the DNA phosphodiester backbone flanking the nick (Arg(333)); penetrate the minor grove and distort the nick (Val(383) and Ile(384)); or stabilize the OB fold (Arg(379)). The essential constituents of the HhH domain include: four glycines (Gly(455), Gly(489), Gly(521), Gly(553)), which bind the phosphate backbone across the minor groove at the outer margins of the LigA-DNA interface; Arg(487), which penetrates the minor groove at the outer margin on the 3 (R)-OH side of the nick; and Arg(446), which promotes protein clamp formation via contacts to the nucleotidyltransferase domain. We find that the BRCT domain is required in its entirety for effective nick sealing and AMP-dependent supercoil relaxation.

  6. Summary of CARE-HHH Mini-Workshop on LHC Crab Cavity Validation, 21 August 2008

    CERN Document Server

    Calaga, R; Garoby, R; Linnecar, T; Tomás, R; Zimmermann, F; CERN. Geneva. BE Department

    2008-01-01

    A global LHC crab-cavity collaboration is rapidly advancing the R&D of a complete crab cavity cryomodule and performing the associated beam dynamics simulations compatible with a prototype test in the phase 0/I upgrade with the aim of establishing a full crab crossing scheme for the phase II upgrade of the LHC. A one day CARE-HHH mini-workshop was held on August 21, 2008 at CERN to discuss crab crossing in the LHC phase 0/I & II upgrades and this reports summarizes the activities of the four sessions that took place during the workshop. The goals of this crab-cavity workshop were fourfold: (1) to discuss prospects of crab cavities in LHC upgrades (2) to review the status of the cryomodule development and beam dynamics, (3) to establish validity requirements for LHC crab cavities which need to be demonstrated prior to their installation into the LHC, and (4) to provide guidance & coordination for the global collaborators.

  7. Home telemonitoring in heart failure patients: the HHH study (Home or Hospital in Heart Failure)

    Science.gov (United States)

    Mortara, Andrea; Pinna, Gian Domenico; Johnson, Paul; Maestri, Roberto; Capomolla, Soccorso; La Rovere, Maria Teresa; Ponikowski, Piotr; Tavazzi, Luigi; Sleight, Peter

    2009-01-01

    Aims The Home or Hospital in Heart failure (HHH) study was a European Community-funded, multinational, randomized controlled clinical trial, conducted in the UK, Poland, and Italy, to assess the feasibility of a new system of home telemonitoring (HT). The HT system was used to monitor clinical and physiological parameters, and its effectiveness (compared with usual care) in reducing cardiac events in heart failure (HF) patients was evaluated. Measurements were patient-managed. Methods and results From 2002 to 2004, 461 HF patients (age 60 ± 11 years, New York Heart Association class 2.4 ± 0.6, left ventricular ejection fraction 29 ± 7%) were enrolled at 11 centres and randomized (1:2) to either usual outpatient care or HT administered as three randomized strategies: (i) monthly telephone contact; (ii) strategy 1 plus weekly transmission of vital signs; and (iii) strategy 2 plus monthly 24 h recording of cardiorespiratory activity. Patients completed 81% of vital signs transmissions, as well as 92% of cardiorespiratory recordings. Over a 12-month follow-up, there was no significant effect of HT in reducing bed-days occupancy for HF or cardiac death plus HF hospitalization. Post hoc analysis revealed a heterogeneous effect of HT in the three countries with a trend towards a reduction of events in Italy. Conclusion Home or Hospital in Heart failure indicates that self-managed HT of clinical and physiological parameters is feasible in HF patients, with surprisingly high compliance. Whether HT contributes to a reduction of cardiac events requires further investigation. PMID:19228800

  8. A novel R275X mutation of the SLC25A15 gene in a Japanese patient with the HHH syndrome.

    Science.gov (United States)

    Torisu, Hiroyuki; Kira, Ryutaro; Kanazawa, Naomi; Takemoto, Megumi; Sanefuji, Masafumi; Sakai, Yasunari; Tsujino, Seiichi; Hara, Toshiro

    2006-06-01

    The hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome (MIM 238970) is an autosomal recessive metabolic disorder caused by a deficiency of the mitochondrial ornithine transporter, one of the urea cycle components. Mutations in the SLC25A15 gene have been coupled to the HHH syndrome. We describe a Japanese female patient with the HHH syndrome due to a novel homozygous R275X SLC25A15 mutation and male sibling who presumably carried the same mutation. He exhibited slowly progressive deterioration with seizures, a gait disturbance due to polyneuropathy, episodic confusion, and died of acute encephalopathy at 34 years of age while the proband exhibited moderate mental retardation, seizures, mild spastic paraplegia, and deafness without neurological deterioration for more than 20 years. The clinical features of previously documented patients with the homozygous SLC25A15 mutation demonstrated that genotype did not simply correlate with clinical severity. The phenotypic variability might depend on other factors, such as dietary and other genetic ones.

  9. The HhH2/NDD domain of the Drosophila Nod chromokinesin-like protein is required for binding to chromosomes in the oocyte nucleus.

    Science.gov (United States)

    Cui, Wei; Hawley, R Scott

    2005-12-01

    Nod is a chromokinesin-like protein that plays a critical role in segregating achiasmate chromosomes during female meiosis. The C-terminal half of the Nod protein contains two putative DNA-binding domains. The first of these domains, known as the HMGN domain, consists of three tandemly repeated high-mobility group N motifs. This domain was previously shown to be both necessary and sufficient for binding of the C-terminal half of Nod to mitotic chromosomes in embryos. The second putative DNA-binding domain, denoted HhH(2)/NDD, is a helix-hairpin-helix(2)/Nod-like DNA-binding domain. Although the HhH(2)/NDD domain is not required or sufficient for chromosome binding in embryos, several well-characterized nod mutations have been mapped in this domain. To characterize the role of the HhH(2)/NDD domain in mediating Nod function, we created a series of UAS-driven transgene constructs capable of expressing either a wild-type Nod-GFP fusion protein or proteins in which the HhH(2)/NDD domain had been altered by site-directed mutagenesis. Although wild-type Nod-GFP localizes to the oocyte chromosomes and rescues the segregation defect in nod mutant oocytes, two of three proteins carrying mutants in the HhH(2)/NDD domain fail to either rescue the nod mutant phenotype or bind to oocyte chromosomes. However, these mutant proteins do bind to the polytene chromosomes in nurse-cell nuclei and enter the oocyte nucleus. Thus, even though the HhH(2)/NDD domain is not essential for chromosome binding in other cell types, it is required for chromosome binding in the oocyte. These HhH(2)/NDD mutants also block the localization of Nod to the posterior pole of stage 9-10A oocytes, a process that is thought to facilitate the interaction of Nod with the plus ends of microtubules (Cui et al. 2005). This observation suggests that the Nod HhH2/NDD domain may play other roles in addition to binding Nod to meiotic chromosomes.

  10. [A case of hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome with spastic paraparesis and severe distal muscle atrophy of lower limbs].

    Science.gov (United States)

    Shigeto, H; Yamada, T; Kobayashi, T; Goto, I

    1992-07-01

    A 16-year-old boy with hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome was reported. He was the second child of first-cousin consanguineous parents. Since childhood, he was mentally retarded and had frequent episodes of vomiting but no unconsciousness attack. Because of progressive gait disturbance since the age of 15, he was admitted to Kyushu University Hospital. Neurological examination revealed mental defect and spastic paraparesis with bilateral positive pathological reflexes. Moreover, severe muscle atrophy and moderate weakness were observed in the distal portion of lower extremities. The diagnosis of HHH syndrome was made by the examination of amino acids in the serum and urine and by the incorporation study of radioactive ornithine into cultured fibroblasts. EMG and nerve biopsy studies suggested that the muscle atrophy seen in this patient was caused by the degeneration of spinal anterior horn cells. Amino acid imbalance, especially elevation of glutamine and glutamic acid in the CSF, may cause dysfunction of neuronal system including anterior horn cells.

  11. Identification of novel mutations in the SLC25A15 gene in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome: a clinical, molecular, and functional study.

    Science.gov (United States)

    Tessa, Alessandra; Fiermonte, Giuseppe; Dionisi-Vici, Carlo; Paradies, Eleonora; Baumgartner, Matthias R; Chien, Yin-Hsiu; Loguercio, Carmela; de Baulny, Helene Ogier; Nassogne, Marie-Cecile; Schiff, Manuel; Deodato, Federica; Parenti, Giancarlo; Rutledge, S Lane; Vilaseca, M Antonia; Melone, Mariarosa A B; Scarano, Gioacchino; Aldamiz-Echevarría, Luiz; Besley, Guy; Walter, John; Martinez-Hernandez, Eugenia; Hernandez, Jose M; Pierri, Ciro L; Palmieri, Ferdinando; Santorelli, Filippo M

    2009-05-01

    Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is an autosomal recessive disorder of the urea cycle. With the exception of the French-Canadian founder effect, no common mutation has been detected in other populations. In this study, we collected 16 additional HHH cases and expanded the spectrum of SLC25A15/ORC1 mutations. Eleven novel mutations were identified including six new missense and one microrearrangement. We also measured the transport properties of the recombinant purified proteins in reconstituted liposomes for four new and two previously reported missense mutations and proved that the transport activities of these mutant forms of ORC1 were reduced as compared with the wild-type protein; residual activity ranged between 4% and 19%. Furthermore, we designed three-dimensional (3D)-modeling of mutant ORC1 proteins. While modeling the changes in silico allowed us to obtain new information on the pathomechanisms underlying HHH syndrome, we found no clear-cut genotype-phenotype correlations. Although patient metabolic alterations responded well to low-protein therapy, predictions concerning the long-term evolution of HHH syndrome remain uncertain. The preference for a hepatic rather than a neurological presentation at onset also continues, largely, to elude us. Neither modifications in oxidative metabolism-related energy, such as those expected in different mtDNA haplogroups, nor sequence variants in SLC25A2/ORC2 seem to be crucial. Other factors, including protein stability and function, and ORC1-ORC2 structural interactions should be further investigated.

  12. The human and mouse SLC25A29 mitochondrial transporters rescue the deficient ornithine metabolism in fibroblasts of patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome.

    Science.gov (United States)

    Camacho, José A; Rioseco-Camacho, Natalia

    2009-07-01

    The hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is a disorder of the urea cycle (UCD) and ornithine degradation pathway caused by mutations in the mitochondrial ornithine transporter (ORNT1). Unlike other UCDs, HHH syndrome is characterized by a less severe and variable phenotype that we believe may, in part, be due to genes with redundant function to ORNT1, such as the previously characterized ORNT2 gene. We reasoned that SLC25A29, a member of the same subfamily of mitochondrial carrier proteins as ORNT1 and ORNT2, might also have overlapping function with ORNT1. Here, we report that both the human and mouse SLC25A29, previously identified as mitochondrial carnitine/acyl-carnitine transporter-like, when overexpressed transiently also rescues the impaired ornithine transport in cultured HHH fibroblasts. Moreover, we observed that, in the mouse, the Slc25a29 message is more significantly expressed in the CNS and cultured astrocytes when compared with the liver and kidney. These results suggest a potential physiologic role for the SLC25A29 transporter in the oxidation of fatty acids, ornithine degradation pathway, and possibly the urea cycle. Our results show that SLC25A29 is the third human mitochondrial ornithine transporter, designated as ORNT3, which may contribute to the milder and variable phenotype seen in patients with HHH syndrome.

  13. Joint CARE-ELAN, CARE-HHH-APD, and EUROTEV-WP3 Workshop on Electron Cloud Clearing

    CERN Document Server

    Scandale, Walter; Schulte, D; Zimmermann, F; Electron Cloud Effects and Technological Consequences; ECL2

    2007-01-01

    This report contains the Proceedings of the joint CARE-HHH-APD, CARE-ELAN, and EUROTEV-WP3 Mini-Workshop on 'Electron Cloud Clearing - Electron Cloud and Technical Consequences', "ECL2", held at CERN in Geneva, Switzerland, 1-2 March 2007). The ECL2 workshop explored novel technological remedies against electron-cloud formation in an accelerator beam pipe. A primary motivation for the workshop was the expected harmful electron-cloud effects in the upgraded LHC injectors and in future linear colliders, as well as recent beam observations in operating facilities like ANKA, CESR, KEKB, RHIC, and SPS. The solutions discussed at ECL2 included enamel-based clearing electrodes, slotted vacuum chambers, NEG coating, and grooves. Several of the proposed cures were assessed in terms of their clearing efficiency and the associated beam impedance. The workshop also reviewed new simulation tools like the 3D electron-ion build-up 'Faktor', modeling assumptions, analytical calculations, beam experiments, and laboratory meas...

  14. Summary of the Mini BNL/LARP/CARE-HHH Workshop on Crab Cavities for the LHC (LHC-CC08)

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Zvi,I.; Calaga, R.; Zimmermann, F.

    2008-05-01

    The first mini-workshop on crab compensation for the LHC luminosity upgrade (LHC-CC08) was held February 24-25, 2008 at the Brookhaven National Laboratory. A total of 35 participants from 3 continents and 15 institutions from around the world participated to discuss the exciting prospect of a crab scheme for the LHC. If realized it will be the first demonstration in hadron colliders. The workshop is organized by joint collaboration of BNL, US-LARP and CARE-HHH. The enormous interest in the subject of crab cavities for the international linear collider and future light sources has resulted in a large international collaboration to exchange aspects of synergy and expertise. A central repository for this exchange of information documenting the latest design effort for LHC crab cavities is consolidated in a wiki page: https://twiki.cern.ch/twiki/bin/view/Main/LHCCrabCavities. The main goal of this workshop was to define a road-map for a prototype crab cavity to be installed in the LHC and to discuss the associated R&D and beam dynamics challenges. The diverse subject of implementing the crab scheme resulted in a scientific program with a wide range of subtopics which were divided into 8 sessions. Each session was given a list of fundamental questions to be addressed and used as a guideline to steer the discussions.

  15. CARE-HHH-APD Workshop on Finalizing the Roadmap for the Upgrade of the CERN and GSI Accelerator Complex

    CERN Document Server

    Zimmermann, Frank; BEAM'07; BEAM 2007; Finalizing the Roadmap for the Upgrade of the LHC and GSI Accelerator Complex

    2008-01-01

    This report contains the Proceedings of the CARE-HHH-APD Event BEAM’07, “Finalizing the Roadmap for the Upgrade of the CERN & GSI Accelerator Complex,” which was held at CERN in Geneva, Switzerland, from 1 to 5 October 2007. BEAM’07 was primarily devoted to beam dynamics limitations for the two, or three, alternative baseline scenarios of the LHC luminosity upgrade and to critical design choices for the upgrade of the LHC injector complex at CERN and for the FAIR complex at GSI. It comprised five parts: (1) a Mini-Workshop on LHC+ Beam Performance, (2) a CERN-GSI Meeting on Collective Effects, (3) the Francesco Ruggiero Memorial Symposium, (4) a Mini-Workshop on the LHC Injectors Upgrade, and (5) the BEAM’07 Summaries. Topics addressed in the first mini-workshop of BEAM’07 ranged from the luminosity performance reach of the upgraded LHC in different scenarios, over the generation and stability of the future LHC beams, the turnaround time, beam–beam effects, luminosity levelling methods, and ...

  16. CARE-HHH-APD Workshop on Interaction Regions for the LHC Upgrade, DAFNE, and SuperB

    CERN Document Server

    Zimmermann, Frank; IR'07; IR 2007

    2008-01-01

    This report contains the Proceedings of the CARE-HHH-APD Mini-Workshop “IR’07,” which was held in Frascati, Italy, from 7 to 9 November 2007. The central theme of the IR’07 Mini-Workshop was the upgrade of the LHC interaction region (IR). A second topic was the experience with the upgraded DAFNE IR as well as the ongoing plans and studies for SuperB, plus possible applications of crab-waist collisions for the LHC upgrade. Discussions during the workshop addressed the performance and limitations of the IR-upgrade optics performance, the optimization of new LHC triplet magnets, the US-LARP magnet strategy (response to Lucio Rossi’s “challenge”), heat deposition, earlyseparation dipoles, detector-integrated quadrupoles, strategy for crab cavities, beam–beam wire compensators, and crab-waist collisions. At IR’07 all auxiliary systems, e.g. wires and crab cavities, received a strong boost. Energy deposition was shown to add an important criterion to the optics requirements—in a first attempt a ...

  17. Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH)-syndrome. Ultrastructural changes of mitochondria in cultured dermal fibroblasts of three patients.

    Science.gov (United States)

    Haust, M D; Dewar, R A; Gatfield, D P; Gordon, B A

    1996-03-01

    Mitochondria of fibroblasts cultured from the skin obtained at biopsy from three patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH)-syndrome, one of the autosomal recessive, heritable urea cycle disorders, were studied with appropriate controls ultrastructurally. The patients were two severely retarded 10- and 12-year-old boys, and a 22-year-old sister of the former whose mental status was at the low normal range; she never had motor impairments or seizures. The mitochondria, similar in all three patients, were increased in number, very long, branching and/or "looping," and tortuous. "Spurs" or "buddings" extended from their lateral surfaces and the terminal segments were often bulbous. Other unusual configurations were also present. In addition, giant forms with large diameter contained innumerable closely-packed and parallel cristae which traversed the entire width of these mitochondria; at times they assumed a "whirled" pattern. The mitochondrial matrix was usually of high electron density. These changes were not a feature of fibroblastic mitochondria of controls. Several changes resembled those of hepatic mitochondria in this disorder. All features are interpreted as an attempt at expanding the mitochondrial volume (via structural substratum) to compensate for the metabolic incompetence of these organelles (a block in transmembranous transfer of ornithine from hyaloplasm into mitochondria for conversion to citrulline).

  18. Long-term monitoring of sleep apnea at home in heart failure patients: preliminary results from the HHH study.

    Science.gov (United States)

    Pinna, G D; Maestri, R; Gobbi, E; Capomolla, S; Campana, C; Emdin, M; Di Lenarda, A; La Rovere, M T; Andrews, D; Johnson, P; Mortara, A; Sleight, P

    2004-01-01

    Sleep apnea is very common in patients with chronic heart failure (CHF) and has important implications in terms of morbidity, mortality and clinical management. Home respiratory telemonitoring might constitute a potential low-cost, widely-applicable alternative to traditional polysomnography in the evaluation and long-term monitoring of breathing disorders in these patients. In this paper we briefly describe the technological infrastructure and present preliminary results of the European Community multicountry trial HHH (Home or Hospital in Heart Failure), which is currently testing a novel system for home telemonitoring of cardiorespiratory signals in CHF patients. The recording and transmitting devices are suitable to be self-managed by the patient. We give a detailed report on the prevalence of nocturnal respiratory disorders at the beginning of the one-year follow-up and on their persistency over the following recordings (one per month). These preliminary findings clearly indicate that intermittent home telemonitoring of respiratory signals based on patient's self-management is feasible in CHF patients and the compliance is high. Reported statistics unambiguously confirm the high prevalence of nocturnal breathing disorders in these patients and clearly show that this phenomenon tends to persist over time.

  19. Epitaxial growth of magnetoresistive (00h), (0hh), and (hhh) La2/3Sr1/3MnO3 thin films on (001)Si substrates

    Science.gov (United States)

    Fontcuberta, J.; Bibes, M.; Martínez, B.; Trtik, V.; Ferrater, C.; Sánchez, F.; Varela, M.

    1999-03-01

    We show that suitable choice of the buffer heterostructure allows us to obtain epitaxial (00h), (0hh), and (hhh) La2/3Sr1/3MnO3 thin films on buffered Si(001) substrates. The magnetotransport properties are investigated. Irrespective of the film texture, it is found that the easy-magnetization direction lies within the film plane. The low-field magnetoresistance is mainly controlled by the in-plane misorientation of crystallites while differences associated with the distinct microstructure of the interfaces appear to have only a second-order effect.

  20. Ornithine and Homocitrulline Impair Mitochondrial Function, Decrease Antioxidant Defenses and Induce Cell Death in Menadione-Stressed Rat Cortical Astrocytes: Potential Mechanisms of Neurological Dysfunction in HHH Syndrome.

    Science.gov (United States)

    Zanatta, Ângela; Rodrigues, Marília Danyelle Nunes; Amaral, Alexandre Umpierrez; Souza, Débora Guerini; Quincozes-Santos, André; Wajner, Moacir

    2016-09-01

    Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is caused by deficiency of ornithine translocase leading to predominant tissue accumulation and high urinary excretion of ornithine (Orn), homocitrulline (Hcit) and ammonia. Although affected patients commonly present neurological dysfunction manifested by cognitive deficit, spastic paraplegia, pyramidal and extrapyramidal signs, stroke-like episodes, hypotonia and ataxia, its pathogenesis is still poorly known. Although astrocytes are necessary for neuronal protection. Therefore, in the present study we investigated the effects of Orn and Hcit on cell viability (propidium iodide incorporation), mitochondrial function (thiazolyl blue tetrazolium bromide-MTT-reduction and mitochondrial membrane potential-ΔΨm), antioxidant defenses (GSH) and pro-inflammatory response (NFkB, IL-1β, IL-6 and TNF-α) in unstimulated and menadione-stressed cortical astrocytes that were previously shown to be susceptible to damage by neurotoxins. We first observed that Orn decreased MTT reduction, whereas both amino acids decreased GSH levels, without altering cell viability and the pro-inflammatory factors in unstimulated astrocytes. Furthermore, Orn and Hcit decreased cell viability and ΔΨm in menadione-treated astrocytes. The present data indicate that the major compounds accumulating in HHH syndrome impair mitochondrial function and reduce cell viability and the antioxidant defenses in cultured astrocytes especially when stressed by menadione. It is presumed that these mechanisms may be involved in the neuropathology of this disease.

  1. Clinical trials update from the joint European Society and World Congress of Cardiology meeting: PEP-CHF, ACCLAIM and the HHH study.

    Science.gov (United States)

    Cleland, John G F; Coletta, Alison P; Clark, Andrew L

    2006-10-01

    This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure, presented at the joint European Society and World Congress of Cardiology meeting held in Barcelona in September 2006. All reports should be considered as preliminary data, as analyses may change in the final publication. The PEP-CHF study suggests that perindopril improves symptoms and functional capacity and may reduce heart failure hospitalisations in patients with diastolic heart failure. Although immune modulation therapy failed to reduce the incidence of all-cause mortality and cardiovascular hospitalisations in the ACCLAIM study, the observed differences in outcome in some heart failure patients warrants further investigation. The HHH study failed to show a beneficial effect of telemonitoring over usual care in patients with heart failure but potentially important country interactions were observed.

  2. Ornithine In Vivo Administration Disrupts Redox Homeostasis and Decreases Synaptic Na(+), K (+)-ATPase Activity in Cerebellum of Adolescent Rats: Implications for the Pathogenesis of Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) Syndrome.

    Science.gov (United States)

    Zanatta, Ângela; Viegas, Carolina Maso; Hickmann, Fernanda Hermes; de Oliveira Monteiro, Wagner; Sitta, Angela; de Moura Coelho, Daniela; Vargas, Carmen Regla; Leipnitz, Guilhian; Wajner, Moacir

    2015-08-01

    Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is an inborn error of metabolism caused by a defect in the transport of ornithine (Orn) into mitochondrial matrix leading to accumulation of Orn, homocitrulline (Hcit), and ammonia. Affected patients present a variable clinical symptomatology, frequently associated with cerebellar symptoms whose pathogenesis is poorly known. Although in vitro studies reported induction of oxidative stress by the metabolites accumulating in HHH syndrome, so far no report evaluated the in vivo effects of these compounds on redox homeostasis in cerebellum. Therefore, the present work was carried out to investigate the in vivo effects of intracerebellar administration of Orn and Hcit on antioxidant defenses (reduced glutathione concentrations and the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase), lipid oxidation (malondialdehyde concentrations), as well as on the activity of synaptic Na(+), K(+)-ATPase, an enzyme highly vulnerable to free radical attack, in the cerebellum of adolescent rats. Orn significantly increased malondialdehyde levels and the activities of all antioxidant enzymes, and reduced Na(+), K(+)-ATPase activity. In contrast, glutathione concentrations were not changed by Orn treatment. Furthermore, intracerebellar administration of Hcit was not able to alter any of these parameters. The present data show for the first time that Orn provokes in vivo lipid oxidative damage, activation of the enzymatic antioxidant defense system, and reduction of the activity of a crucial enzyme involved in neurotransmission. It is presumed that these pathomechanisms may contribute at least partly to explain the neuropathology of cerebellum abnormalities and the ataxia observed in patients with HHH syndrome.

  3. Prenatal exclusion of the HHH syndrome.

    Science.gov (United States)

    Gray, R G; Green, A; Hall, S; McKeown, C

    1995-05-01

    Prenatal diagnosis of the hyperornithinaemia, hyperammonaemia, and homocitrullinuria syndrome is described by the analysis of ornithine incorporation in second-trimester cultured amniotic fluid cells. An unaffected fetus was predicted and confirmed in the newborn child. This is the third reported prenatal diagnosis for this disorder and the second predicting an unaffected fetus.

  4. Evidence of CP violation in B -> hhh charmless decays

    CERN Document Server

    CERN. Geneva

    2012-01-01

    We present the first evidence of CP violation in the B+→ pi+pi-pi+,  B+→ K+pi+pi-, B+→ K+K-pi+ and B+→K+K-K+ decays using the 1.0 fb-1 of data collected by the LHCb experiment during 2011. The results show that the 3pi and Kpipi channels present a positive asymmetry while the KKpi and KKK modes present a negative asymmetry. We also study the variation of the CP violation effects in the phase space of each three-body decay.  We find significant inhomogeneities that reveal regions with particularly large asymmetries in the pipi and KK low mass regions in B+→pi+pi-pi+ and B+→K+K-pi+ respectively.

  5. Fertilizer intensification and its impacts in China's HHH Plains

    Science.gov (United States)

    The accomplishment of China’s food security by application of high rates of fertilizers has generated several controversies regarding the quality of soil and water resources. Thus, the objective of this article is to assess the effects and causes of the fertilizer intensification in the Huang Huai ...

  6. chi_cJ Decays to h^+h^-h^0

    CERN Document Server

    Athar, S; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Wiss, J; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z V; Seth, K K; Tomaradze, A G; Ernst, J; Severini, H; Dytman, S A; Love, W; Savinov, V; Aquines, O; Li, Z; López, A; Mehrabyan, S S; Méndez, H; Ramírez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Brock, I; Chen, J; Ferguson, T; Tatishvili, G T; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M

    2006-01-01

    Using a sample of 3x10^6 psi(2S) decays recorded by the CLEO detector, we study three body decays of the chi_{c0}, chi_{c1}, and chi_{c2} produced in radiative decays of the psi(2S). We consider the decay modes pi+ pi- eta, K+ K- eta, p pbar eta, pi+ pi- etaprime, K+ K- pi0, p pbar pi0, pi+ K- K0S, and K+ pbar Lambda measuring branching fractions or placing upper limits. For chi_{c1} to pi+ pi- eta, K+ K- pi0, and pi+ K- K0S our observed samples are large enough to study the substructure in a Dalitz plot analysis. The results presented in this document are preliminary.

  7. chi_{cJ} Decays to h^+h^-h^0

    CERN Document Server

    Athar, S; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z V; Seth, K K; Tomaradze, A G; Ernst, J; Severini, H; Love, W; Savinov, V; Aquines, O; Li, Z; López, A; Mehrabyan, S S; Méndez, H; Ramírez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Ferguson, T; Tatishvili, G T; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; al, et

    2007-01-01

    Using a sample of 3 million psi(2S) decays recorded by the CLEO detector, we study three-body decays of the chi_c0, chi_c1, and chi_c2 produced in radiative decays of the psi(2S). We consider the final states pi+ pi- eta, K+ K- eta, p p-bar eta, pi+ pi- eta-prime, K+ K- pi0, p p-bar pi0, pi+ K- K0S, and K+ p-bar Lambda, measuring branching fractions or placing upper limits. For chi_c1 decays to pi+ pi- eta, K+ K- pi0, and pi+ K- K0S our observed samples are large enough to study the substructure in a Dalitz plot analysis.

  8. Summy of the working groupI of the care HHH LUMI-2005 workshop

    CERN Document Server

    Brüning, Oliver Sim

    2006-01-01

    The working group I of the LUMI-2005 workshop was asked to put together a catalogue of basic design options for the IR solutions for an LHC-upgrade. The goal of the working group was to discuss the different solutions with respect to the maximum beta-functions inside the first focusing quadrupole magnets and the resulting required quadrupole apertures the chromatic aberrations on the one hand and the implications for the magnet technology on the other hand. Such a comparison requires a wide range of input data ranging from the expected loss patterns at the magnetic elements and the resulting peak and average heat deposition to the obtainable peak magnetic field and quench limits for different magnet design options and the correct ability of the chromatic aberrations for a given optics design. Given the wide spectrum of relevant input data the working group could not yet prepare a final ranking of the various design options. Rather the working group succeeded in fixing some of the key boundary conditions in or...

  9. 40 CFR Table 3 to Subpart Hhh of... - Operating Parameters To Be Monitored and Minimum Measurement and Recording Frequencies

    Science.gov (United States)

    2010-07-01

    ... mercury (Hg) sorbent flow rate Hourly Once per hour ✔ ✔ Minimum pressure drop across the wet scrubber or... rural HMIWI HMIWI a with dry scrubber followed by fabric filter HMIWI a with wet scrubber HMIWI a with dry scrubber followed by fabric filter and wet scrubber Maximum operating parameters: Maximum...

  10. AAA-DDD triple hydrogen bond complexes.

    Science.gov (United States)

    Blight, Barry A; Camara-Campos, Amaya; Djurdjevic, Smilja; Kaller, Martin; Leigh, David A; McMillan, Fiona M; McNab, Hamish; Slawin, Alexandra M Z

    2009-10-01

    Experiment and theory both suggest that the AAA-DDD pattern of hydrogen bond acceptors (A) and donors (D) is the arrangement of three contiguous hydrogen bonding centers that results in the strongest association between two species. Murray and Zimmerman prepared the first example of such a system (complex 3*2) and determined the lower limit of its association constant (K(a)) in CDCl(3) to be 10(5) M(-1) by (1)H NMR spectroscopy (Murray, T. J. and Zimmerman, S. C. J. Am. Chem. Soc. 1992, 114, 4010-4011). The first cationic AAA-DDD pair (3*4(+)) was described by Bell and Anslyn (Bell, D. A. and Anslyn, E. A. Tetrahedron 1995, 51, 7161-7172), with a K(a) > 5 x 10(5) M(-1) in CH(2)Cl(2) as determined by UV-vis spectroscopy. We were recently able to quantify the strength of a neutral AAA-DDD arrangement using a more chemically stable AAA-DDD system, 6*2, which has an association constant of 2 x 10(7) M(-1) in CH(2)Cl(2) (Djurdjevic, S., Leigh, D. A., McNab, H., Parsons, S., Teobaldi, G. and Zerbetto, F. J. Am. Chem. Soc. 2007, 129, 476-477). Here we report on further AA(A) and DDD partners, together with the first precise measurement of the association constant of a cationic AAA-DDD species. Complex 6*10(+)[B(3,5-(CF(3))(2)C(6)H(3))(4)(-)] has a K(a) = 3 x 10(10) M(-1) at RT in CH(2)Cl(2), by far the most strongly bound triple hydrogen bonded system measured to date. The X-ray crystal structure of 6*10(+) with a BPh(4)(-) counteranion shows a planar array of three short (NH...N distances 1.95-2.15 A), parallel (but staggered rather than strictly linear; N-H...N angles 165.4-168.8 degrees), primary hydrogen bonds. These are apparently reinforced, as theory predicts, by close electrostatic interactions (NH-*-N distances 2.78-3.29 A) between each proton and the acceptor atoms of the adjacent primary hydrogen bonds.

  11. 40 CFR Table 1 to Subpart Ddd of... - Applicability of General Provisions (40 CFR Part 63, Subpart A) to Subpart DDD of Part 63

    Science.gov (United States)

    2010-07-01

    ... (40 CFR Part 63, Subpart A) to Subpart DDD of Part 63 1 Table 1 to Subpart DDD of Part 63 Protection... Hazardous Air Pollutants for Mineral Wool Production Pt. 63, Subpt. DDD, Table 1 Table 1 to Subpart DDD of Part 63—Applicability of General Provisions (40 CFR Part 63, Subpart A) to Subpart DDD of Part...

  12. About ATC/DDD drug clasiffication system

    Directory of Open Access Journals (Sweden)

    Diana Iacob (Obistioiu,

    2009-06-01

    Full Text Available The field of drug utilization research has attracted increasing interest since its infancy in the 1960s. At a symposium in Oslo in 1969 entitled The Consumption of Drugs, it was agreed that an internationally accepted classification system for drug consumption studies was needed. At the same symposium the Drug UtilizationResearch Group (DURG was established and tasked with the development of internationally applicable methods for drug utilization research.By modifying and extending the European Pharmaceutical Market Research Association (EPhMRA classification system, Norwegian researchers developed a system known as the Anatomical TherapeuticChemical (ATC classification. In order to measure drug use, it is important to have both a classification system and a unit of measurement. To deal with the objections against traditional units of measurement, a technical unit of measurement called the Defined Daily Dose (DDD to be used in drug utilisation studies was developed. The purpose of the ATC/DDD system is to serve as a tool for drug utilization research in order to improve quality of drug use. One component of this is the presentation and comparison of drug consumption statistics at international and other levels. The classification of a substance in the ATC/DDD system is not a recommendation for use, nor does it imply any judgements about efficacy or relative efficacy of drugs and groups of drugs.The Anatomical Therapeutic Chemical classification system for veterinary medicinal products, ATCvet, has been developed by the Nordic Council on Medicines (NLN in collaboration with the NLN’sATCvet working group, consisting of experts from the Nordic countries.The ATCvet system for the classification of veterinary medicines is based on the same overall principles as the ATC system for substances used in human medicine. In most cases an ATC code exists which can beused to classify a product in the ATCvet system. The ATCvet code is then created by placing

  13. 40 CFR 129.101 - DDT, DDD and DDE.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false DDT, DDD and DDE. 129.101 Section 129... POLLUTANT EFFLUENT STANDARDS Toxic Pollutant Effluent Standards and Prohibitions § 129.101 DDT, DDD and DDE. (a) Specialized definitions. (1) DDT Manufacturer means a manufacturer, excluding any source which...

  14. 黄淮海平原土地生态服务功能浅析%Analysis on Land Ecosystem Services of HHH Plain in China

    Institute of Scientific and Technical Information of China (English)

    杨君; 郝晋珉; 白玮; 余宝林; 谢敏

    2006-01-01

    随着人们生活水平的提高和可持续发展研究的深入,对生态环境的保护和研究也逐步得以重视,生态服务功能的探讨也逐渐成为生态经济学研究的一个热点.黄淮海平原水资源短缺问题日益严重,成为土地生态系统健康的主要制约因素之一.水资源短缺也是广大平原地区土地生态服务功能减弱的主要因素,成为全面建设小康社会所要求的生态环境质量的主要制约因素.因此,文章以河北省为例,分析了平原地区生态服务功能低下的原因,并提出相关建议,以期更好地提高我国粮食安全保证率,为可持续发展服务.

  15. A novel mutation in the SLC25A15 gene in a Turkish patient with HHH syndrome: functional analysis of the mutant protein.

    Science.gov (United States)

    Ersoy Tunalı, Nagehan; Marobbio, Carlo M T; Tiryakioğlu, N Ozan; Punzi, Giuseppe; Saygılı, Seha K; Onal, Hasan; Palmieri, Ferdinando

    2014-05-01

    The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome is a rare autosomal recessive disorder caused by the functional deficiency of the mitochondrial ornithine transporter 1 (ORC1). ORC1 is encoded by the SLC25A15 gene and catalyzes the transport of cytosolic ornithine into mitochondria in exchange for citrulline. Although the age of onset and the severity of the symptoms vary widely, the disease usually manifests in early infancy. The typical clinical features include protein intolerance, lethargy, episodic confusion, cerebellar ataxia, seizures and mental retardation. In this study, we identified a novel p.Ala15Val (c.44C>T) mutation by genomic DNA sequencing in a Turkish child presenting severe tantrum, confusion, gait disturbances and loss of speech abilities in addition to hyperornithinemia, hyperammonemia and homocitrullinuria. One hundred Turkish control chromosomes did not possess this variant. The functional effect of the novel mutation was assessed by both complementation of the yeast ORT1 null mutant and transport assays. Our study demonstrates that the A15V mutation dramatically interferes with the transport properties of ORC1 since it was shown to inhibit ornithine transport nearly completely.

  16. Risk factor analysis for bone marrow histiocytic hyperplasia with hemophagocytosis: an autopsy study.

    Science.gov (United States)

    Inai, Kunihiro; Noriki, Sakon; Iwasaki, Hiromichi; Naiki, Hironobu

    2014-07-01

    The excessive release of inflammatory cytokines occasionally induces life-threatening hemophagocytosis referred to as hemophagocytic syndrome (HPS). A similar condition, histiocytic hyperplasia with hemophagocytosis (HHH), is often seen in bone marrow collected during autopsy. Unlike HPS, the pathogenesis of HHH remains unclear. Therefore, we performed a clinicopathological analysis of HHH from 70 autopsy cases at the University of Fukui Hospital. HHH was detected in 29 of 70 autopsies (41.4 %) and was significantly complicated with hematological diseases (p HHH (p HHH patients as compared with non-HHH patients. Concentrations of inflammatory mediators including IL-1β, IL-6, and IL-8 were significantly increased in HHH patients. Multivariate risk factor analysis identified hematological diseases (odds ratio (OR), 11.71), ≥ 15 % BM macrophages (OR, 9.42), sepsis (OR, 7.77), and high serum IL-6 levels (OR, 1.00) as independent risk factors for HHH. HHH with hypocellular BM, the most aggressive form of HHH, was recognized in 8 of 29 HHH patients and was associated with ≥ 25 % BM macrophages (p HHH patients fulfilled the diagnostic criteria of HPS. These findings suggest that HHH is a different entity from HPS and that it preferentially develops under conditions of excessive inflammation and its associated risks, such as hematological diseases and sepsis.

  17. Molecularly Defined Nanostructures Based on a Novel AAA-DDD Triple Hydrogen-Bonding Motif.

    Science.gov (United States)

    Papmeyer, Marcus; Vuilleumier, Clément A; Pavan, Giovanni M; Zhurov, Konstantin O; Severin, Kay

    2016-01-26

    A facile and flexible method for the synthesis of a new AAA-DDD triple hydrogen-bonding motif is described. Polytopic supramolecular building blocks with precisely oriented AAA and DDD groups are thus accessible in few steps. These building blocks were used for the assembly of large macrocycles featuring four AAA-DDD interactions and a macrobicyclic complex with a total of six AAA-DDD interactions.

  18. Data of evolutionary structure change: 1CTJA-351CA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available J A 1CTJA EQFLD-GGFNI ...1CTJA-351CA 1CTJ 351C A A EADLALGKAVFDGN-CAACHAGGGNNVIPDHTLQKAAIE...HHHH -- HHHHHHHHHHHH ----- 0 1CT...ure>HHH - Hure> ATOM...Chain> AAKFAGQAGAE ure>HHH HH

  19. 40 CFR 96.281 - General.

    Science.gov (United States)

    2010-07-01

    ....208, and subparts BBB and CCC and subparts FFF through HHH of this part, a CAIR SO2 opt-in unit shall...) Solely for purposes of applying, as provided in this subpart, the requirements of subpart HHH of...

  20. 40 CFR 97.254 - Compliance with CAIR SO2 emissions limitation.

    Science.gov (United States)

    2010-07-01

    ... sulfur dioxide emissions, determined in accordance with subpart HHH of this part, from all CAIR SO2 units... subpart HHH of this part, from all CAIR SO2 units at the source for the control period; or (ii) If...

  1. 40 CFR 96.254 - Compliance with CAIR SO2 emissions limitation.

    Science.gov (United States)

    2010-07-01

    ... sulfur dioxide emissions, determined in accordance with subpart HHH of this part, from all CAIR SO2 units... subpart HHH of this part, from all CAIR SO2 units at the source for the control period; or (ii) If...

  2. A Formal Verification Methodology for DDD Mode Pacemaker Control Programs

    Directory of Open Access Journals (Sweden)

    Sana Shuja

    2015-01-01

    Full Text Available Pacemakers are safety-critical devices whose faulty behaviors can cause harm or even death. Often these faulty behaviors are caused due to bugs in programs used for digital control of pacemakers. We present a formal verification methodology that can be used to check the correctness of object code programs that implement the safety-critical control functions of DDD mode pacemakers. Our methodology is based on the theory of Well-Founded Equivalence Bisimulation (WEB refinement, where both formal specifications and implementation are treated as transition systems. We develop a simple and general formal specification for DDD mode pacemakers. We also develop correctness proof obligations that can be applied to validate object code programs used for pacemaker control. Using our methodology, we were able to verify a control program with millions of transitions against the simple specification with only 10 transitions. Our method also found several bugs during the verification process.

  3. 77 FR 47631 - Agency Information Collection Activities: Request for Comments on Twenty-Four Proposed...

    Science.gov (United States)

    2012-08-09

    ...: NSPS for Synthetic Fiber Production Facilities (40 CFR Part 60, Subpart HHH). ICR Numbers: EPA ICR..., 2012. (9) NSPS for Synthetic Fiber Production Facilities (40 CFR Part 60, Subpart HHH); Learia Williams... Part 60, Subpart HHH); Docket ID Number EPA-HQ-OECA-2012-0528; EPA ICR Number 1156.12; OMB...

  4. 40 CFR 96.284 - Opt-in process.

    Science.gov (United States)

    2010-07-01

    ... accordance with subpart HHH of this part. A determination of sufficiency shall not be construed as acceptance... unit and all other applicable parameters, in accordance with subpart HHH of this part, starting on the date of certification of the appropriate monitoring systems under subpart HHH of this part...

  5. 40 CFR 96.206 - Standard requirements.

    Science.gov (United States)

    2010-07-01

    ... requirements of subpart HHH of this part. (2) The emissions measurements recorded and reported in accordance with subpart HHH of this part shall be used to determine compliance by each CAIR SO2 source with the... HHH of this part. (2) A CAIR SO2 unit shall be subject to the requirements under paragraph (c)(1)...

  6. 40 CFR 97.284 - Opt-in process.

    Science.gov (United States)

    2010-07-01

    ... monitored and reported in accordance with subpart HHH of this part. A determination of sufficiency shall not... rate and the heat input of the unit and all other applicable parameters, in accordance with subpart HHH... subpart HHH of this part and continuing until a CAIR opt-in permit is denied under § 97.284(f) or, if...

  7. Chiral effects in adrenocorticolytic action of o,p'-DDD (mitotane) in human adrenal cells.

    Science.gov (United States)

    Asp, V; Cantillana, T; Bergman, A; Brandt, I

    2010-03-01

    Adrenocortical carcinoma (ACC) is a rare malignant disease with poor prognosis. The main pharmacological choice, o,p'-DDD (mitotane), produces severe adverse effects. Since o,p'-DDD is a chiral molecule and stereoisomers frequently possess different pharmacokinetic and/or pharmacodynamic properties, we isolated the two o,p'-DDD enantiomers, (R)-(+)-o,p'-DDD and (S)-(-)-o,p'-DDD, and determined their absolute structures. The effects of each enantiomer on cell viability and on cortisol and dehydroepiandrosterone (DHEA) secretion in the human adrenocortical cell line H295R were assessed. We also assayed the o,p'-DDD racemate and the m,p'- and p,p'-isomers. The results show small but statistically significant differences in activity of the o,p'-DDD enantiomers for all parameters tested. The three DDD isomers were equally potent in decreasing cell viability, but p,p'-DDD affected hormone secretion slightly less than the o,p'- and m,p'-isomers. The small chiral differences in direct effects on target cells alone do not warrant single enantiomer administration, but might reach importance in conjunction with possible stereochemical effects on pharmacokinetic processes in vivo.

  8. MR PROSTATE SEGMENTATION VIA DISTRIBUTED DISCRIMINATIVE DICTIONARY (DDD) LEARNING.

    Science.gov (United States)

    Guo, Yanrong; Zhan, Yiqiang; Gao, Yaozong; Jiang, Jianguo; Shen, Dinggang

    2013-01-01

    Segmenting prostate from MR images is important yet challenging. Due to non-Gaussian distribution of prostate appearances in MR images, the popular active appearance model (AAM) has its limited performance. Although the newly developed sparse dictionary learning method[1, 2] can model the image appearance in a non-parametric fashion, the learned dictionaries still lack the discriminative power between prostate and non-prostate tissues, which is critical for accurate prostate segmentation. In this paper, we propose to integrate deformable model with a novel learning scheme, namely the Distributed Discriminative Dictionary (DDD) learning, which can capture image appearance in a non-parametric and discriminative fashion. In particular, three strategies are designed to boost the tissue discriminative power of DDD. First, minimum Redundancy Maximum Relevance (mRMR) feature selection is performed to constrain the dictionary learning in a discriminative feature space. Second, linear discriminant analysis (LDA) is employed to assemble residuals from different dictionaries for optimal separation between prostate and non-prostate tissues. Third, instead of learning the global dictionaries, we learn a set of local dictionaries for the local regions (each with small appearance variations) along prostate boundary, thus achieving better tissue differentiation locally. In the application stage, DDDs will provide the appearance cues to robustly drive the deformable model onto the prostate boundary. Experiments on 50 MR prostate images show that our method can yield a Dice Ratio of 88% compared to the manual segmentations, and have 7% improvement over the conventional AAM.

  9. DDT, DDE and DDD in human milk from South Africa.

    Science.gov (United States)

    Okonkwo, Jonathan Okechukwu; Mutshatshi, Tshinanne N; Botha, Ben; Agyei, Nana

    2008-10-01

    Human breast milk samples (n=30) were collected from mothers within the age range of 19-40 years from Thohoyandou area, South Africa. DDT and its metabolites were extracted from the milk samples using diethyl ether. The crude extracts were subjected to column chromatography. The eluates were then evaporated on a stream of nitrogen up to 0.5 mL. One microliter of the cleaned extracts were injected into GC-ECD for selected organochlorine compounds. The sum total of DDT and its metabolites from each village ranged from not detectable for DMS, GNN and THN to 1,930 ng g(-1) fat wt for BDL while SigmaDDE ranged from 1.32 ng g(-1) fat wt for GNN to 2,570 ng g(-1) fat wt for TKD. SigmaDDD ranged from not detectable for GNN to 4,060 ng g(-1) fat wt for MNN. SigmaDDE was the most predominant followed by SigmaDDD and finally SigmaDDT. This was an indication of breakdown of the parent compound, DDT. Some villages namely, Lufule and Budeli, and Maniini and Makhuvha exhibited similar DDT occurrence of 89% in their areas. Other villages, DMS, TLM, and MND and TKD showed a similarity percentage of 82% while others showed similarities of 75% for GNN and MTT, 69% and 65% for MPG and THN respectively. A significant cluster of DDT and its metabolites between the infants' weight range of 2.5-3.9 kg/body wt was observed. Increase in lipid content was followed by a decrease in the sum DDT in the older mothers (27-30). The estimated daily intake varied from 260 to 4,696 ng/g, nd-10,551 ng/g and nd-4,237 ng/g for DDE, DDD and DDT respectively. These values are significantly (p<0.05) higher than the FAO/WHO acceptable daily intake (ADI) of 20 ng/g. The SigmaDDT was found to decrease with increasing age of the mothers. The observed high levels of DDE compared to DDT indicated chronic exposure of the mothers to DDT, which is metabolised to DDE and retained in the body.

  10. Interindividual differences in o,p'-DDD enantiomer kinetics examined in Göttingen minipigs.

    Science.gov (United States)

    Cantillana, T; Lindström, V; Eriksson, L; Brandt, I; Bergman, A

    2009-06-01

    Five minipigs were given a single oral dose of a racemic mixture of o,p'-DDD (30 mg kg(-1)b.w., EF=0.49). Blood plasma and subcutaneous adipose tissue were collected for analysis, at different time-points over 180 d. At the end of the experiment also liver, kidney and brain tissue were collected. Low concentrations of o,p'-DDD still remained after 180 d in plasma (mean 0.5+/-0.3 ng g(-1)f.w.) and in adipose tissue (mean 40+/-40 ng g(-1)f.w.). The mean concentrations in liver and kidney were 500+/-300 pg g(-1)f.w. and 90+/-50 pg g(-1)f.w., respectively. The enantiomers of o,p'-DDD were isolated by HPLC and the absolute configuration of the enantiomers were determined by X-ray crystallography and polarimetry as R-(+)-o,p'-DDD and S-(-)-o,p'-DDD. The enantiomer fractions (EFs) of o,p'-DDD were determined in plasma, adipose tissue and kidney using GC/ECD equipped with a chiral column. The EFs of o,p'-DDD in the individual minipigs showed large variability, ranging from 0.2 to 0.6 after 24h in plasma and from 0.2 to 0.7 after 90 d in adipose tissue. Hence in two of the minipigs, the S-(-)-o,p'-DDD enantiomer was dominating while the other enantiomer, R-(+)-o,p'-DDD was dominating in three minipigs. We propose that a yet not identified factor related to polymorphism, regulating the metabolism and/or elimination of the enantiomeric o,p'-DDD, is responsible for the differences in enantiomeric retention of the compound in the minipigs.

  11. Some misunderstandings about DDD%关于约定日剂量的几个误区

    Institute of Scientific and Technical Information of China (English)

    陈志东

    2013-01-01

    Objective: To analyze some misunderstandings about define daily dose (DDD). Methods: The misunderstandings about DDD are found by comparing Chinese articles on drug utilization analysis. Results: There are four kinds of misunderstandings about DDD, the first is to limit daily dose, the second is prescribed daily dose, the third is different from individual assigner, and the fourth is multi-assignment methods. Conclusion: There are some misunderstandings about DDD in China, and attention should be paid because they are not conducive to carrying out the work of drug utilization analysis.%  目的:对 DDD 的误区进行分析。方法:通过对国内药物利用分析类文献的比较,找出 DDD 的误区。结果:国内 DDD 的误区体现在4个方面:DDD 是临床限制用药剂量、DDD 是处方日剂量、DDD 设定行为个体化和 DDD 设定方法多样化。结论:我国 DDD 存在一些误区,不利于药物利用分析工作的开展,应引起足够重视。

  12. Re-use of explanted DDD pacemakers as VDD- clinical utility and cost effectiveness.

    Science.gov (United States)

    Namboodiri, K K N; Sharma, Y P; Bali, H K; Grover, A

    2004-01-01

    Re-use of DDD pulse generators explanted from patients died of unrelated causes is associated with an additional cost of two transvenous leads if implanted as DDD itself, and high rate of infection according to some studies. We studied the clinical and economical aspects of reutilization of explanted DDD pacemakers programmed to VDD mode. Out of 28 patients who received VDD pacemaker during the period, October 2000- September 2001 in the Department of Cardiology, PGIMER, Chandigarh, 5 poor patients were implanted with explanted DDD pulse generators programmed to VDD mode. Each implantation was planned and carried out according to a standard protocol. The age ranged from 45 to 75 (mean-61) years. The indications for pacing were complete heart block (4) and second degree AV block (1). The clinical profile, costs and complications, if any were noted and followed up at regular intervals. The results were compared with patients who received new DDD pulse generators during this period. The additional cost for the atrial lead was not required in these patients. None of these patients had any local site infection. Compared to the two-lead system, the single lead system provided more rapid implantation and minimized complications associated with placement of an atrial lead. The explanted DDD pacemaker can be safely reused as VDD mode with same efficacy in selected patient population. This is associated with lower cost and complications compared to reimplantation as DDD itself.

  13. The structure of RdDddP from Roseobacter denitrificans reveals that DMSP lyases in the DddP-family are metalloenzymes.

    Directory of Open Access Journals (Sweden)

    Jan-Hendrik Hehemann

    Full Text Available Marine microbes degrade dimethylsulfoniopropionate (DMSP, which is produced in large quantities by marine algae and plants, with DMSP lyases into acrylate and the gas dimethyl sulfide (DMS. Approximately 10% of the DMS vents from the sea into the atmosphere and this emission returns sulfur, which arrives in the sea through rivers and runoff, back to terrestrial systems via clouds and rain. Despite their key role in this sulfur cycle DMSP lyases are poorly understood at the molecular level. Here we report the first X-ray crystal structure of the putative DMSP lyase RdDddP from Roseobacter denitrificans, which belongs to the abundant DddP family. This structure, determined to 2.15 Å resolution, shows that RdDddP is a homodimeric metalloprotein with a binuclear center of two metal ions located 2.7 Å apart in the active site of the enzyme. Consistent with the crystallographic data, inductively coupled plasma mass spectrometry (ICP-MS and total reflection X-ray fluorescence (TRXF revealed the bound metal species to be primarily iron. A 3D structure guided analysis of environmental DddP lyase sequences elucidated the critical residues for metal binding are invariant, suggesting all proteins in the DddP family are metalloenzymes.

  14. 黄淮海平原地下水危机下的耕地资源可持续利用%Cropland Sustainable Use Impacted by Groundwater Depletion in China's HHH Plains

    Institute of Scientific and Technical Information of China (English)

    张雪靓; 孔祥斌

    2014-01-01

    研究目的:基于多数据源计算黄淮海平原地下水位平均下降速度,揭示该地区地下水快速下降机理,提出水资源限制下的耕地可持续利用对策.研究方法:根据收集的黄淮海平原266个地下水位下降速度样本点和5个典型城市地下水位长期监测点,由克里格插值得到区域地下水位平均下降速度,并采用空间分析的方法叠加2012年耕地分布图,分析不同地下水下降速度在9个子生态区对应的耕地分布情况.研究结果:1980年以来,黄淮海平原地下水以浅层0.46±0.37m/年,深层1.14±0.58 m/年的速度下降,成为世界上面积最大的地下水漏斗区.造成地下水快速下降的主要原因是区域粮食增产和一年两熟种植制度下小麦播种面积的增加导致的大面积、高强度的井灌方式.根据地下水资源危机程度,将黄淮海平原划分为休养调整区、强度降低区、生态保护区和潜力提升区4个耕地利用调整区划.研究结论:黄淮海平原高集约高投入的耕地利用方式不可持续,在区域地下水危机的情况下,应降低超采区的耕地利用强度,同时提升潜力区的耕地生产潜力,实现耕地生产、生态质量协同提升,在保障粮食安全和生态安全的前提下实现耕地资源可持续利用.

  15. 黄淮海区域早熟大白菜品种比较试验与规模化种植管理%Comparison Test on Earliness Chinese Cabbages and Scale Planting Management in the HHH Region

    Institute of Scientific and Technical Information of China (English)

    李菊花

    2007-01-01

    将几个常见的早熟大白菜品种,在黄淮平原常温下生产的抗病性、品质及适应性进行对比实验,用实验结果筛选出产量高、效益好的大白菜品种,向菜农提供规模化、科学化生产管理模式的科学依据,为全区规模化发展高效蔬菜奠定基础.

  16. 1982~2000年黄淮海地区植被覆盖变化特征分析%Analysis on the Vegetation Cover Change in the HHH Zone of China in 1982~2000

    Institute of Scientific and Technical Information of China (English)

    莫瑶; 郑有飞; 陈怀亮; 邹春辉

    2007-01-01

    利用1982~2000年8km NOAA-AVHRR数据,采用均值法、差值法和一元线性回归模拟法,分析了中国黄淮海地区植被的动态变化及其空间分布特征,模拟了年NDVI均值的变化趋势,并对不同植被类型的NDVI年内和年际变化规律进行了分析.结果表明:黄淮海地区植被覆盖总体上呈增加趋势,20世纪90年代末相对80年代初平均NDVI值增加了近0.03.从空间分布上看,大部分地区NDVI都呈增加的趋势,其中NDVI极显著增加的区域主要分布在山东的西北部和西部、河南的东部、河北的北部及江苏的北部地区,F检验的显著性水平达到了99%.NDVI呈减少趋势的地区很少,主要分布在北京、天津、山西中部.各植被类型的NDVI在年内的变化呈很强的季节性,年际变化规律大致相同,呈波动上升的趋势.

  17. HHH堵漏剂在治理多点井漏中的应用%Application of HHH LCM to Lost Circulation Control at Multiple Points in a Well

    Institute of Scientific and Technical Information of China (English)

    肖波; 李晓阳; 陈忠实; 程常修; 刘滨

    2008-01-01

    在异常高压区的深井钻井中,经常遇到以压裂性诱导漏失为主的多漏点井漏,该类型井漏的漏失位置往往难以确定,各漏失点差异性较大,一次性治理成功往往存在复杂的技术难题.针对川渝地区同裸眼多漏点井漏使用HHH堵漏剂一次性全部封堵成功率不高的问题,通过分析多漏点井漏的漏失特性和HHH堵漏剂应用于多漏点堵漏的工艺技术,认为现场堵漏施工工艺的优化对提高多漏点井漏治理成功率十分关键,在施工中优化堵漏浆挤注排量可以实现同裸眼多漏点的一次性堵漏成功.在剑门1井多漏点井漏的堵漏施工实践中,几次作业通过调整优化施工工艺,从正反两方面证实了优化现场工艺能够提高同裸眼多漏点井漏的一次性治理成功率.

  18. 锐利的调试器DDD

    Institute of Scientific and Technical Information of China (English)

    车皓阳

    2004-01-01

    在嵌入式程序开发过程中,程序员要进行大量的调试.以此验证程序的正确性,修改潜在的错误。调试器对于程序员来说是不可或缺的必备工具。在Linux环境中,有很多调试工具和调试辅助工具,例如GDB、XXGDB、RHIDE,XWPE、GVD和DDD等。其中,DDD是命令行调试器的图形前端,除了一般的程序调试功能以外,还具有交互式图形数据显示的功能。它在嵌人式应用开发中也十分出色。本文主要讲述DDD(Data Display Debugger)的使用方法。

  19. Dechlorination of DDT, DDD and DDE in soil (slurry) phase using magnesium/palladium system.

    Science.gov (United States)

    Gautam, Sumit Kumar; Suresh, Sumathi

    2006-12-01

    Mg0/Pd4+ was able to dechlorinate >99% of extractable DDT (initial concentration of 10 mg DDT kg(-1) of soil) and >90% of extractable DDT (initial concentration of 50 mg DDT kg(-1) of soil) in soil slurry. Mg0/Pd4+ was also found to be effective in dechlorinating of 50 mg kg(-1) DDD and DDE, in soil aged for varying time periods. GC-MS analyses revealed the formation of 1,1-diphenylethane as an end product from DDT, DDE and DDD. To the best of our knowledge this is the first report describing the application Mg0/Pd4+ system for remediation of DDT, DDD and DDE contaminated soil. We conclude that reductive dechlorination reaction catalyzed by Mg0/Pd4+ may be a promising system to remediate soil contaminated with DDT and its dechlorinated products such as DDD and DDE.

  20. Irreversible binding of o,p'-DDD in interrenal cells of Atlantic cod (Gadus morhua).

    Science.gov (United States)

    Lindhe, Orjan; Brandt, Ingvar; Christiansen, Jørgen Schou; Ingebrigtsen, Kristian

    2003-03-01

    Precision-cut tissue slices of the anterior kidney from Atlantic cod (Gadus morhua) were prepared with a Krumdieck tissue slicer and exposed to 2-(2-chlorophenyl)-2-(4-chloro-(14C)phenyl)-1,1-dichlorethane (o,p(')-[14C]DDD) in vitro. Microautoradiography revealed irreversible o,p(')-DDD-derived binding confined to the glucocorticoid producing interrenal cells (adrenocortical analogues). This cell-selective binding was confirmed by means of autoradiography at different levels of resolution on Atlantic cod administered o,p(')-[14C]DDD intragastrically. The results provide evidence for a site-specific metabolic activation and irreversible binding of o,p(')-DDD in the interrenal cells, which, in turn, may modify glucocorticoid homeostasis.

  1. Optimal pacing for symptomatic AV block: a comparison of VDD and DDD pacing.

    Science.gov (United States)

    Huang, Max; Krahn, Andrew D; Yee, Raymond; Klein, George J; Skanes, Allan C

    2004-01-01

    VDD pacing provides the physiological benefits of atrioventricular synchronous pacing with the convenience of a single lead system, but is hampered by uncertainty regarding long term atrial sensing and potential development of sinus node disease. To examine the long-term reliability and complication rates of VDD pacing, we compared the outcome of 112 consecutive patients (age 70 +/- 13 years, 59% men) with symptomatic AV block who received a single pass bipolar VDD system, to 80 patients (age 63 +/- 16 years, 70% men) who received DDD pacing for the same indication. All patients were judged to have intact sinus node function based on submitted ECGs and monitoring results at the time of implant. Implant time was reduced in VDD patients compared to DDD patients (63 +/- 20 vs 97 +/- 36 minutes, P DDD patients compared to 3 (3%) VDD patients (P = 0.15). The implant P wave was lower with VDD pacing compared to DDD patients (2.91 +/- 1.48 vs 4.0 +/- 1.7 mv, P DDD patients. Physiological atrioventricular activation was maintained in 94%-99% of beats throughout the follow-up period in the VDD group. VDD pacing is an excellent strategy for treatment of patients with symptomatic AV block. The lower cost, high reliability, and abbreviated implantation time suggest that VDD pacing is a viable alternative to DDD pacing in patients with high degree AV block and normal sinus node function.

  2. Isolation of Brazilian marine fungi capable of growing on DDD pesticide.

    Science.gov (United States)

    Ortega, Scarlet Nere; Nitschke, Marcia; Mouad, Ana Maria; Landgraf, Maria Diva; Rezende, Maria Olímpia Oliveira; Seleghim, Mirna Helena Regali; Sette, Lara Durães; Porto, André Luiz Meleiro

    2011-02-01

    The fungi Aspergillus sydowii Ce15, Aspergillus sydowii Ce19, Aspergillus sydowii Gc12, Bionectria sp. Ce5, Penicillium miczynskii Gc5, Penicillium raistrickii Ce16 and Trichoderma sp. Gc1, isolated from marine sponges Geodia corticostylifera and Chelonaplysylla erecta, were evaluated for their ability to grow in the presence of DDD pesticide. Increasing concentrations of DDD pesticide, i.e., 5.0 mg (1.56 × 10⁻¹² mmol), 10.0 mg (3.12 × 10⁻²) mmol) and 15.0 mg (4.68 × 10⁻² mmol) in solid and liquid culture media were tested. The fungi Trichoderma sp. Gc1 and Penicillium miczynskii Gc5 were able to grow in the presence of up to 15.0 mg of DDD, suggesting their potential for biodegradation. A 100% degradation of DDD was attained in liquid culture medium when Trichoderma sp. Gc1 was previously cultivated for 5 days and supplemented with 5.0 mg of DDD in the presence of hydrogen peroxide. However, the quantitative analysis showed that DDD was accumulated on mycelium and biodegradation level reached a maximum value of 58% after 14 days.

  3. An AAA-DDD triply hydrogen-bonded complex easily accessible for supramolecular polymers.

    Science.gov (United States)

    Han, Yi-Fei; Chen, Wen-Qiang; Wang, Hong-Bo; Yuan, Ying-Xue; Wu, Na-Na; Song, Xiang-Zhi; Yang, Lan

    2014-12-15

    For a complementary hydrogen-bonded complex, when every hydrogen-bond acceptor is on one side and every hydrogen-bond donor is on the other, all secondary interactions are attractive and the complex is highly stable. AAA-DDD (A=acceptor, D=donor) is considered to be the most stable among triply hydrogen-bonded sequences. The easily synthesized and further derivatized AAA-DDD system is very desirable for hydrogen-bonded functional materials. In this case, AAA and DDD, starting from 4-methoxybenzaldehyde, were synthesized with the Hantzsch pyridine synthesis and Friedländer annulation reaction. The association constant determined by fluorescence titration in chloroform at room temperature is 2.09×10(7)  M(-1) . The AAA and DDD components are not coplanar, but form a V shape in the solid state. Supramolecular polymers based on AAA-DDD triply hydrogen bonded have also been developed. This work may make AAA-DDD triply hydrogen-bonded sequences easily accessible for stimuli-responsive materials.

  4. DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.

    Science.gov (United States)

    Rajagopalan, Parthasarathi; Tracey, Heather; Chen, Zhoumou; Bandyopadhyaya, Acintya; Veeraraghavan, Sridhar; Rajagopalan, Desikan R; Salvemini, Daniela; McPhee, Ian; Viswanadha, Srikant; Rajagopalan, Raghavan

    2014-07-15

    DDD-028 (4), a novel pentacyclic pyridoindolobenzazepine derivative was evaluated in vitro for receptor binding affinity and in vivo for analgesic activity using rodent models of neuropathic and inflammatory pain. DDD-028 does not bind to opioid, cannabinoid, dopamine, or histamine receptors. DDD-028 is very active even at the low oral dose of 1-5 mg/kg in both neuropathic, (spinal nerve ligation and chronic constriction injury) and inflammatory (Complete Freund's Adjuvant Induced) models of pain. DDD-028 appears to be about 6-fold more potent than pregabalin and indomethacin. Visual observation of all the animals used in these studies indicated that DDD-028 is well tolerated without any sedation. Thus, DDD-028 seems to be a promising candidate for the treatment of neuropathic and inflammatory pain without the possible side effects or abuse potential associated with opioid or cannabinoid activities.

  5. The organochlorine o,p'-DDD disrupts the adrenal steroidogenic signaling pathway in rainbow trout (Oncorhynchus mykiss).

    Science.gov (United States)

    Lacroix, Martin; Hontela, Alice

    2003-08-01

    The mechanisms of action of o,p'-DDD on adrenal steroidogenesis were investigated in vitro in rainbow trout (Oncorhynchus mykiss). Acute exposures to o,p'-DDD inhibited ACTH-stimulated cortisol secretion while cell viability decreased significantly only at the highest concentration tested (200 microM o,p'-DDD). Stimulation of cortisol secretion with a cAMP analogue (dibutyryl-cAMP) was inhibited at a higher concentration than that needed to inhibit ACTH-stimulated cortisol synthesis in cells exposed to o,p'-DDD. Forskolin-stimulated cortisol secretion and cAMP production, and NaF-stimulated cAMP production were inhibited in a concentration-dependent manner by o,p'-DDD. In contrast, basal cortisol secretion was stimulated while basal cAMP production was unaffected by o,p'-DDD. Pregnenolone-stimulated cortisol secretion was enhanced by o,p'-DDD at a physiologically relevant pregnenolone concentration, while o,p'-DDD inhibited cortisol secretion when a pharmacological concentration of pregnenolone was used. Our results suggest that the cAMP generation step is a target in o,p'-DDD-mediated disruption of ACTH-stimulated adrenal steroidogenesis in rainbow trout but that other downstream targets such as steroidogenic enzymes responsible for cortisol synthesis might also be affected.

  6. Bioavailability to grains of rice of aged and fresh DDD and DDE in soils.

    Science.gov (United States)

    Yao, Fenxia; Yu, Guifen; Bian, Yongrong; Yang, Xinglun; Wang, Fang; Jiang, Xin

    2007-05-01

    DDT had been widely used around the world before 1980s and is still under production and use for non-agricultural purposes in China. Because of their special physicochemical properties, p,p'-DDT and its main metabolites, p,p'-DDD and p,p'-DDE, accumulated and persisted in the environment, presenting potential menace on biota. A green-house study was conducted to determine the bioavailability of p,p'-DDD and p,p'-DDE to grains of rice and the influences of traditional Chinese farming practices on their bioaccumulation. Paddy rice and dry rice were grown in submerged paddy soils and non-submerged upland soils, respectively. Two types of soil, Hydragric Anthrosols (An) and Hydragric Acrisols (Ac), were employed. Bioaccumulation factors (BAFs) of DDE ranged from 0.67 for rice grown in non-submerged An to 0.84 in submerged An in the control group, whilst BAFs were all below 0.04 in experimental groups. BAFs of DDD varied from 1.39 for submerged An to 2.26 for submerged Ac in original soils. In contrast, BAFs were between 0.05 for non-submerged Ac and 0.08 for submerged An in DDD-contaminated soils. Flooding seemed to have two contradictory effects on the DDE/DDD accumulation by rice: on one hand, it made the pollutants more mobile and bioavailable; while on the other hand, it enhanced the degradation and binding of POPs. Adding rice straw to the soils protected DDE from being taken up yet promoted DDD accumulation by rice. Furthermore, the distinct inorganic component of the soils might also play an important role in the environmental activities of POPs.

  7. Who is Eligible for DDD Services? Report No. 5.24.

    Science.gov (United States)

    Kohlenberg, Elizabeth; And Others

    The effects of broadening the definition of eligibility for services from the Washington State Division of Developmental Disabilities (DDD) are analyzed. Five different definitions are discussed. The existing definition includes: (1) "statutory conditions," which includes persons who are mentally retarded or have difficulty carrying out major life…

  8. Complete dechlorination of DDE/DDD using magnesium/palladium system.

    Science.gov (United States)

    Gautam, Sumit Kumar; Suresh, Sumathi

    2007-04-01

    Kinetic studies on the dechlorination of 1,1-dichloro-2,2 bis (4,-chlorophenyl) ethane (DDD) and 1,1,dichloro-2,2 bis (4,-chlorophenyl) ethylene (DDE) in 0.05% biosurfactant revealed that the reaction follows second-order kinetics. The rate of reaction was dependent on the presence of acid, initial concentrations of the target compound, and zerovalent magnesium/tetravalent palladium. Gas chromatography-mass spectrometry analyses of DDE dechlorination revealed the formation of a completely dechlorinated hydrocarbon skeleton, with diphenylethane as the end product, thereby implying the removal of all four chlorine atoms of DDE. In the case of DDD, we identified two partially dechlorinated intermediates [namely, 1,1-dichloro-2, 2 bis (phenyl) ethane and 1, chloro-2, 2 bis (phenyl) ethane] and diphenylethane as the end product. On the basis of products formed from DDD dehalogenation, we propose the removal of aryl chlorine atoms as a first step. Our investigation reveals that biosurfactant may be an attractive solubilizing agent for DDT and its residues. The magnesium/palladium system is a promising option because of its high reactivity and ability to achieve complete dechlorination of DDE and DDD.

  9. The effect of DDD on single ranvier nodes of Xenopus laevis

    NARCIS (Netherlands)

    Bercken, J. van den

    1969-01-01

    Membrane potentials of single Ranvier nodes of myelinated nerve fibres were measured. DDD suppressed the rising phase of the action potential, probably by a reduction of the inward sodium current. This effect is in sharp contrast to that of DDT, which does not affect the rising phase but slows down

  10. Biochemical, Kinetic, and Spectroscopic Characterization of Ruegeria pomeroyi DddW--A Mononuclear Iron-Dependent DMSP Lyase.

    Directory of Open Access Journals (Sweden)

    Adam E Brummett

    Full Text Available The osmolyte dimethylsulfoniopropionate (DMSP is a key nutrient in marine environments and its catabolism by bacteria through enzymes known as DMSP lyases generates dimethylsulfide (DMS, a gas of importance in climate regulation, the sulfur cycle, and signaling to higher organisms. Despite the environmental significance of DMSP lyases, little is known about how they function at the mechanistic level. In this study we biochemically characterize DddW, a DMSP lyase from the model roseobacter Ruegeria pomeroyi DSS-3. DddW is a 16.9 kDa enzyme that contains a C-terminal cupin domain and liberates acrylate, a proton, and DMS from the DMSP substrate. Our studies show that as-purified DddW is a metalloenzyme, like the DddQ and DddP DMSP lyases, but contains an iron cofactor. The metal cofactor is essential for DddW DMSP lyase activity since addition of the metal chelator EDTA abolishes its enzymatic activity, as do substitution mutations of key metal-binding residues in the cupin motif (His81, His83, Glu87, and His121. Measurements of metal binding affinity and catalytic activity indicate that Fe(II is most likely the preferred catalytic metal ion with a nanomolar binding affinity. Stoichiometry studies suggest DddW requires one Fe(II per monomer. Electronic absorption and electron paramagnetic resonance (EPR studies show an interaction between NO and Fe(II-DddW, with NO binding to the EPR silent Fe(II site giving rise to an EPR active species (g = 4.29, 3.95, 2.00. The change in the rhombicity of the EPR signal is observed in the presence of DMSP, indicating that substrate binds to the iron site without displacing bound NO. This work provides insight into the mechanism of DMSP cleavage catalyzed by DddW.

  11. Further characterization of diabetes mellitus and body weight loss in males of the congenic mouse strain DDD.Cg-A(y.).

    Science.gov (United States)

    Suto, Jun-ichi; Satou, Kunio

    2015-02-01

    The A(y) allele at the agouti locus causes obesity and promotes linear growth in mice. However, body weight gain stops between 16 and 17 weeks after birth, and then, body weight decreases gradually in DDD.Cg-A(y) male mice. Body weight loss is a consequence of diabetes mellitus, which is genetically controlled mainly by a quantitative trait locus (QTL) on chromosome 4. This study aimed to further characterize diabetes mellitus and body weight loss in DDD.Cg-A(y) males. The number of β-cells was markedly reduced, and plasma insulin levels were very low in the DDD.Cg-A(y) males. Using a backcross progeny of DDD × (B6 × DDD.Cg-A(y)) F1-A(y), we identified one significant QTL for plasma insulin levels on distal chromosome 4, which was coincidental with QTL for hyperglycemia and lower body weight. The DDD allele was associated with decreased plasma insulin levels. When the DDD.Cg-A(y) males were housed under three different housing conditions [group housing (4 or 5 DDD.Cg-A(y) and DDD males), individual housing (single DDD.Cg-A(y) male) and single male housing with females (single DDD.Cg-A(y) male with DDD.Cg-A(y) or DDD females)], diabetes mellitus and body weight loss were most severely expressed in individually housed mice. Thus, the severity of diabetes and body weight loss in the DDD.Cg-A(y) males was strongly influenced by the housing conditions. These results demonstrate that both genetic and nongenetic environmental factors are involved in the development of diabetes mellitus and body weight loss in the DDD.Cg-A(y) males.

  12. Flood forecasting with DDD-application of a parsimonious hydrological model in operational flood forecasting in Norway

    Science.gov (United States)

    Skaugen, Thomas; Haddeland, Ingjerd

    2014-05-01

    A new parameter-parsimonious rainfall-runoff model, DDD (Distance Distribution Dynamics) has been run operationally at the Norwegian Flood Forecasting Service for approximately a year. DDD has been calibrated for, altogether, 104 catchments throughout Norway, and provide runoff forecasts 8 days ahead on a daily temporal resolution driven by precipitation and temperature from the meteorological forecast models AROME (48 hrs) and EC (192 hrs). The current version of DDD differs from the standard model used for flood forecasting in Norway, the HBV model, in its description of the subsurface and runoff dynamics. In DDD, the capacity of the subsurface water reservoir M, is the only parameter to be calibrated whereas the runoff dynamics is completely parameterised from observed characteristics derived from GIS and runoff recession analysis. Water is conveyed through the soils to the river network by waves with celerities determined by the level of saturation in the catchment. The distributions of distances between points in the catchment to the nearest river reach and of the river network give, together with the celerities, distributions of travel times, and, consequently unit hydrographs. DDD has 6 parameters less to calibrate in the runoff module than the HBV model. Experiences using DDD show that especially the timing of flood peaks has improved considerably and in a comparison between DDD and HBV, when assessing timeseries of 64 years for 75 catchments, DDD had a higher hit rate and a lower false alarm rate than HBV. For flood peaks higher than the mean annual flood the median hit rate is 0.45 and 0.41 for the DDD and HBV models respectively. Corresponding number for the false alarm rate is 0.62 and 0.75 For floods over the five year return interval, the median hit rate is 0.29 and 0.28 for the DDD and HBV models, respectively with false alarm rates equal to 0.67 and 0.80. During 2014 the Norwegian flood forecasting service will run DDD operationally at a 3h temporal

  13. Substituent effects in double-helical hydrogen-bonded AAA-DDD complexes.

    Science.gov (United States)

    Wang, Hong-Bo; Mudraboyina, Bhanu P; Wisner, James A

    2012-01-27

    Two series of DDD and AAA hydrogen-bond arrays were synthesized that form triply-hydrogen-bonded double-helical complexes when combined in CDCl(3) solution. Derivatization of the DDD arrays with electron-withdrawing groups increases the complex association constants by up to a factor of 30 in those arrays examined. Derivatization of the AAA arrays with electron donating substituents reveals a similar magnitude effect on the complex stabilities. The effect of substitution on both types of arrays are modeled quite satisfactorily (R(2) > 0.96 in all cases) as free energy relationships with respect to the sums of their Hammett substituent constants. In all, the complex stabilities can be manipulated over more than three orders of magnitude (>20 kJ mol(-1)) using this type of modification.

  14. High ventricular lead impedance of a DDD pacemaker after cranial magnetic resonance imaging.

    Science.gov (United States)

    Baser, Kazim; Guray, Umit; Durukan, Mine; Demirkan, Burcu

    2012-09-01

    Management of electromagnetic interference in the form of magnetic resonance imaging (MRI) in patients with pacemakers (PMs) may be challenging. Serious consequences, especially in PM-dependent patients, may be encountered. Changes in device programming, asynchronous pacing, heating of the lead tip(s), and increased thresholds or even device dislocation may be experienced. We report of a patient with a DDD PM who underwent an emergent MRI, after which there was an increase in ventricular impedance as well as increased cardiac biomarkers.

  15. A morphometric study of the adrenal cortex of the female DDD mouse.

    Science.gov (United States)

    Tsujio, Masashi; Mizorogi, Toshihiro; Nishijima, Kazutoshi; Kuwahara, Sachi; Aoyama, Hiroaki; Ohno, Tamio; Tanaka, Shin

    2009-02-01

    The aim of this study was to determine whether the thickness of the adrenocortical zone is associated with age in virgin and parous female DDD mice. The zona reticularis and zona glomerulosa of parous mice tended to be thicker than those of virgin mice at all ages. The zona fasciculata lactating parous mice was significantly thicker than that of virgin mice at 20 weeks of age (PDDD mice less than one year of age.

  16. Effects of right atrial and ventricular DDD pacing on cardiac function and ventricular contraction synchrony

    Institute of Scientific and Technical Information of China (English)

    支力大; 华伟; 张澍; 史蓉芳; 王方正; 陈新

    2004-01-01

    Background Right ventricular apical pacing has been reported to reduce cardiac performance. But there are few reports on the effects of dual chamber (DDD) pacing on cardiac function compared to sinus rhythm. In this study, we evaluated the effects of right atrial and ventricular DDD pacing on cardiac function and ventricular contraction synchrony using equilibrium radionuclide angiography.Methods Ten patients implanted with a right atrial and ventricular DDD pacemaker underwent equilibrium radionuclide angiography. The scintigraphic data were obtained during sinus rhythm and pacing rhythm. Cardiac function parameters were obtained semimanually. Phase analysis was used to study the ventricular activation sequence and ventricular synchrony.Results The left ventricular 1/3 ejection fraction decreased significantly during pacing compared with that during sinus rhythm[(23.4 ±6.1)% vs(27.7 ±4.5)%, P =0.01]. Regional ejection fraction also decreased during pacing, although the difference was not statistically significant. Phase analysis showed that the right ventricle was activated earlier than the left ventricle during pacing, and that the phase shift was significantly greater during pacing than that during sinus rhythm[64.13°±16.80° vs 52.88°± 9.26°, P =0.007]. The activation of both ventricles occurred simultaneously during sinus rhythm, with the activation sequence from proximal septum or base of left ventricle to apex. The earliest activation during pacing occurred at the right ventricular apex, and subsequently spread to the base and left ventricle.Conclusion Right atrial and ventricular DDD pacing impairs left ventricular systolic function and ventricular synchrony.

  17. Characterization of mitotane (o,p'-DDD)--cyclodextrin inclusion complexes: phase-solubility method and NMR.

    Science.gov (United States)

    Alfonsi, R; Attivi, D; Astier, A; Socha, M; Morice, S; Gibaud, S

    2013-05-01

    Mitotane (o,p'-dichlorodimethyl dichloroethane [o,p'-DDD]) is used for the treatment of adrenocortical cancer and occasionally Cushing's syndrome. This drug is very poorly soluble in water, and following oral administration, approximately 60% of the dose is recovered in the feces unaltered. The preparation of a soluble formulation (i.e. by complexation with cyclodextrins) with improved bioavailability is the aim of this work. The inclusion of mitotane in methyl-ß-cyclodextrins was studied using both phase-solubility methods and NMR experiments. To elucidate the inclusion mechanism, o,p'-DDD was compared to its regioisomer (i.e. p,p'-DDD). It was demonstrated that two dimethyl-ß-cyclodextrins (DMßCD) can complex with the aromatic rings. From the phase-solubility diagrams, we observe that both cases are very different: K(1:1) is between 37 000 and 85 000 mol.l(-1), whereas K(1:2) is between 5.3 and 32 mol.l(-1). The NMR experiments confirmed the inclusion but it also gave an insight into the kinetics of the dissociation: the ortho-chloro moiety is in slow exchange on the NMR time scale, whereas the para-chloro moiety is in fast exchange rate.

  18. The two faces of hydrogen-bond strength on triple AAA-DDD arrays.

    Science.gov (United States)

    Lopez, Alfredo Henrique Duarte; Caramori, Giovanni Finoto; Coimbra, Daniel Fernando; Parreira, Renato Luis Tame; da Silva, Éder Henrique

    2013-12-01

    Systems that are connected through multiple hydrogen bonds are the cornerstone of molecular recognition processes in biology, and they are increasingly being employed in supramolecular chemistry, specifically in molecular self-assembly processes. For this reason, the effects of different substituents (NO2, CN, F, Cl, Br, OCH3 and NH2) on the electronic structure, and consequently on the magnitude of hydrogen bonds in triple AAA-DDD arrays (A=acceptor, D=donor) were evaluated in the light of topological [electron localization function (ELF) and quantum theory of atoms in molecules (QTAIM)], energetic [Su-Li energy-decomposition analysis (EDA) and natural bond orbital analysis (NBO)], and geometrical analysis. The results based on local H-bond descriptors (geometries, QTAIM, ELF, and NBO) indicate that substitutions with electron-withdrawing groups on the AAA module tend to strengthen, whereas electron-donating substituents tend to weaken the covalent character of the AAA-DDD intermolecular H-bonds, and also indicate that the magnitude of the effect is dependent on the position of substitution. In contrast, Su-Li EDA results show an opposite behavior when compared to local H-bond descriptors, indicating that electron-donating substituents tend to increase the magnitude of H-bonds in AAA-DDD arrays, and thus suggesting that the use of local H-bond descriptors describes the nature of H bonds only partially, not providing enough insight about the strength of such H bonds.

  19. Ventricular evoked response in patients with hypertrophic obstructive cardiomyopathy treated with DDD pacing

    Directory of Open Access Journals (Sweden)

    João Ricardo M. Sant'Anna

    1999-08-01

    Full Text Available OBJECTIVE: To assess the changes in ventricular evoked responses (VER produced by the decrease in left ventricular outflow tract gradient (LVOTG in patients with hypertrophic obstructive cardiomyopathy (HOCM treated with dual-chamber (DDD pacing. METHODS: A pulse generator Physios CTM (Biotronik, Germany was implanted in 9 patients with severe drug-refractory HOCM. After implantation, the following conditions were assessed: 1 Baseline evaluation: different AV delay (ranging from 150ms to 50 ms were sequentially programmed during 5 to 10 minutes, and the LVOTG (as determined by Doppler echocardiography and VER recorded; 2 standard evaluation, when the best AV delay (resulting in the lowest LVOTG programmed at the initial evaluation was maintained so that its effect on VER and LVOTG could be assessed during each chronic pacing evaluation. RESULTS: LVOTG decreased after DDD pacing, with a mean value of 59 ± 24 mmHg after dual chamber pacemaker, which was significantly less than the gradient before pacing (98 + 22mmHg. An AV delay >100ms produced a significantly lower decrease in VER depolarization duration (VER DD when compared to an AV delay <=100ms. Linear regression analyses showed a significant correlation between the LVOTG values and the magnitude of VER (r=0.69; p<0.05 in the 9 studied patients. CONCLUSION: The telemetry obtained intramyocardial electrogram is a sensitive means to assess left ventricular dynamics in patients with HOCM treated with DDD pacing.

  20. Long-term outcome in patients receiving permanent pacemaker implantation for atrioventricular block: Comparison of VDD and DDD pacing.

    Science.gov (United States)

    Liao, Jo-Nan; Chao, Tze-Fan; Tuan, Ta-Chuan; Kong, Chi-Woon; Chen, Shih-Ann

    2016-08-01

    A permanent pacemaker (PPM) with dual chamber pacing (DDD) offers atrioventricular synchronization for patients with atrioventricular block (AVB). Single lead atrial synchronous ventricular pacing mode (VDD) is an alternative, but there are concerns about its efficacy and risk of atrial undersensing. Whether VDD can be a good alternative in patients with AVB remains unknown. The aim of the present study was to compare the long-term risk of mortality of VDD with DDD pacing.A total of 207 patients undergoing PPM implantations for AVB with VDD mode were enrolled from 2000 to 2013. Another 828 age- and sex-matched patients undergoing DDD implantations during the same period of time were selected as the control group in a 1 to 4 ratio. The study endpoint was mortality.A total of 1035 patients (64.3% male) were followed up for 46.5 ± 43.2 months. The mean ages were 75.0 years for VDD, and 74.9 years for DDD. The Kaplan-Meier survival analysis showed no significant difference in long-term survival between the VDD and DDD groups (log-rank P = 0.313). After adjustment for baseline characteristics, the VDD and DDD groups had a similar long-term prognosis with an adjusted hazard ratio of 0.875 (P = 0.445). Further analyses for the risk of cardiovascular and noncardiovascular deaths also showed no significant differences between the 2 groups.The long-term prognosis of VDD mode is comparable to that of DDD mode. Single lead VDD can be considered as an alternative choice in patients with AVB without sinus nodal dysfunction.

  1. New Mechanistic Insight from Substrate- and Product-Bound Structures of the Metal-Dependent Dimethylsulfoniopropionate Lyase DddQ.

    Science.gov (United States)

    Brummett, Adam E; Dey, Mishtu

    2016-11-08

    The marine microbial catabolism of dimethylsulfoniopropionate (DMSP) by the lyase pathway liberates ∼300 million tons of dimethyl sulfide (DMS) per year, which plays a major role in the biogeochemical cycling of sulfur. Recent biochemical and structural studies of some DMSP lyases, including DddQ, reveal the importance of divalent transition metal ions in assisting DMSP cleavage. While DddQ is believed to be zinc-dependent primarily on the basis of structural studies, excess zinc inhibits the enzyme. We examine the importance of iron in regulating the DMSP β-elimination reaction catalyzed by DddQ as our as-isolated purple-colored enzyme possesses ∼0.5 Fe/subunit. The UV-visible spectrum exhibited a feature at 550 nm, consistent with a tyrosinate-Fe(III) ligand-to-metal charge transfer transition. Incubation of as-isolated DddQ with added iron increases the intensity of the 550 nm peak, whereas addition of dithionite causes a bleaching as Fe(III) is reduced. Both the Fe(III) oxidized and Fe(II) reduced species are active, with similar kcat values and 2-fold differences in their Km values for DMSP. The slow turnover of Fe(III)-bound DddQ allowed us to capture a substrate-bound form of the enzyme. Our DMSP-Fe(III)-DddQ structure reveals conformational changes associated with substrate binding and shows that DMSP is positioned optimally to bind iron and is in the proximity of Tyr 120 that acts as a Lewis base to initiate catalysis. The structures of Tris-, DMSP-, and acrylate-bound forms of Fe(III)-DddQ reported here illustrate various states of the enzyme along the reaction pathway. These results provide new insights into DMSP lyase catalysis and have broader significance for understanding the mechanism of oceanic DMS production.

  2. Triaspartate: a model system for conformationally flexible DDD motifs in proteins.

    Science.gov (United States)

    Duitch, Laura; Toal, Siobhan; Measey, Thomas J; Schweitzer-Stenner, Reinhard

    2012-05-01

    Understanding the interactions that govern turn formation in the unfolded state of proteins is necessary for a complete picture of the role that these turns play in both normal protein folding and functionally relevant yet disordered linear motifs. It is still unclear, however, whether short peptides can adopt stable turn structures in aqueous environments in the absence of any nonlocal interactions. To explore the effect that nearest-neighbor interactions and the local peptide environment have on the turn-forming capability of individual amino acid residues in short peptides, we combined vibrational (IR, Raman, and VCD), UV-CD, and (1)H NMR spectroscopies in order to probe the conformational ensemble of the central aspartic acid residue of the triaspartate peptide (DDD). The study was motivated by the recently discovered turn propensities of aspartic acid in GDG (Hagarman; et al. Chem.-Eur. J. 2011, 17, 6789). We investigated the DDD peptide under both acidic and neutral conditions in order to elucidate the effect that side-chain protonation has on the conformational propensity of the central aspartic acid residue. Amide I' profiles were analyzed in terms of two-dimensional Gaussian distributions representing conformational subdistributions in Ramachandran space. Interestingly, our results show that while the protonated form of the DDD peptide samples various turn-like conformations similar to GDG, deprotonation of the peptide eliminates this propensity for turns, causing the fully ionized peptide to exclusively sample pPII and β-strand-like structures. To further explore the factors stabilizing these more extended conformations in fully ionized DDD, we analyzed the temperature dependence of both the UV-CD spectrum and the (3)J(H(N),H(α)) coupling constants of the two amide protons (N- and C-terminal) in terms of a simple two-state (pPII-β) thermodynamic model. Thus, we were able to obtain the enthalpic and entropic differences between the pPII and

  3. Unita di consumo dei farmaci e valutazioni farmacoeconomiche: uso e misuso di DDD e PDD

    Directory of Open Access Journals (Sweden)

    Mario Eandi

    2002-12-01

    Full Text Available In pharmacoeconomical evaluations the quantification of drug utilization has to be done on the basis of measurement units that allow comparisons among series of longitudinal and transversal data. The most common techniques used for the analysis and the comparison of drug utilization patterns are based either on the Defined Daily Dose (DDD, a unit system proposed by WHO’s Drug Utilization Research Group, or on the Prescribed Daily Dose (PDD, a statistical parameter obtained from the analysis of drug prescriptions. This article illustrates the meaning of the main indicators of drug consumption that can be build with these techniques, underlining their utility and limitations. The DDD is the conventionally established theoretical mean daily dose of a drug, referred to a way of administration and to its main indication. It is, therefore, a mere technical measurement unit that cannot be interpreted as mean prescribed or consumed dose, and even less as recommended dose. The PDD, on the contrary, is not a measurement unit but a statistical mean value, that expresses the central tendency of the prescription variability in a defined setting. Starting from Italian data on the consumption of wide-spread antibiotics, the use and interpretation of various indicators based on the DDDs and PDDs are discussed. The parameters derived with the DDD technique are suitable for monitoring drug utilization and pharmaceutical expenditure. The PDD method is more direct, indicates the mean quantities actually prescribed and permits the estimation of the total dose consumed per therapeutic cycle and of other clinically relevant parameters, but requires the acquisition of more data than the other technique does. It is also important to remark the fact that both methods can’t be directly used for economical evaluations trying to assess the efficiency of resource allocation, as they are not correlated to the clinical outcomes of the therapy.

  4. Data of evolutionary structure change: 1LCTA-1BP5A [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1LCTA-1BP5A 1LCT 1BP5 A A RSVQWCAVSNPEATKCFQWQRNMRKV---RGPPVSCIKR...> 0 1LCT A 1LCT...A NMRKV---RGPPV ure>H...GPSV ure>HHH ure> ATOM 174 CA HIS A 25...pdbChain> 1BP5A PEPRK--PLEKA ure> -- HHH

  5. Data of evolutionary structure change: 1BJFB-2CT9B [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 9 B 2CT9B TSLDKGENGTLS ...1BJFB-2CT9B 1BJF 2CT9 B B ---NSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCP-...in>1BJFB LRDCP--SGHLS ure>HHH -- EEEE...>LEU CA 338 SER CA 279 2CT...ure>HHH EEure> ATOM 1785 CA THR B 36 25.632 42.23

  6. Data of evolutionary structure change: 1CG8A-2DN1B [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available equence>FSGFE-----ACNEQ ure> ----- HH> B 2DN1B FGDLSTPDAVMGNPK re>G HHHH HH...ence>VNLQA-FTPVT >HH - HHH> 2DN1 B 2DN1B HHFGKEFTPPV ...>HHHGGG HHH> ATOM 1931 CA HIS B 116 17.758 39.

  7. Effect of changes in diet energy density on feed intake, milk yield and metabolic parameters in dairy cows in early lactation

    DEFF Research Database (Denmark)

    Nielsen, N.I.; Friggens, N.C.; Larsen, T.

    2007-01-01

    calving while cows assigned to HHH or NNN were fed the same TMR for all 9 weeks. Results from cows on treatment HNH were compared with group HHH while cows on treatment NHN were compared with group NNN. When the diet changed from N to H and H to N, cows increased and decreased their dry-matter intake (DMI...

  8. 40 CFR 97.281 - General.

    Science.gov (United States)

    2010-07-01

    ... CCC and subparts FFF through HHH of this part, a CAIR SO2 opt-in unit shall be treated as a CAIR SO2... applying, as provided in this subpart, the requirements of subpart HHH of this part to a unit for which...

  9. 40 CFR 97.206 - Standard requirements.

    Science.gov (United States)

    2010-07-01

    ... subpart HHH of this part. (2) The emissions measurements recorded and reported in accordance with subpart HHH of this part shall be used to determine compliance by each CAIR SO2 source with the CAIR SO2... the control period from all CAIR SO2 units at the source, as determined in accordance with subpart...

  10. Influence of o'p-DDD on the physiological response to stress in Arctic charr (Salvelinus alpinus).

    Science.gov (United States)

    Jørgensen, E H; Balm, P H; Christiansen, J S; Plotitsyna, N; Ingebrigtsen, K

    2001-10-01

    Various toxicants have previously been held responsible for an impaired capacity of fish from polluted environments to elevate their cortisol levels in response to stress. In the present study we investigated the responses to stress in o'p-DDD [2-(chlorophenyl)-2-(4-chlorphenyl)-1,1-dichloroethane] exposed (given a single, oral dose of 75 mg o'p-DDD/kg fish) and unexposed Arctic charr. After o'p-DDD administration fish were left undisturbed and without being fed for 28 days, when they were subjected to an acute handling stress. At 1, 3, 7 and 23 h following stress, primary (ACTH and cortisol secretion) and secondary (plasma Cl levels and energy mobilisation) components of the stress response were monitored. As the nutritional state of wild fish may influence this potential biomarker response, the fish had been subjected to a restricted feed ration prior to o'p-DDD administration in order to obtain marked within-group variations in condition factor. No effects of o'p-DDD were observed on post-stress hormone secretion (i.e. peak post-stress plasma ACTH and cortisol levels), nor on plasma chloride levels. However, other results obtained provided evidence for a metabolic depression by o'p-DDD, witnessed by consistently lower plasma glucose levels before and after stress in these contaminated fish. This may be related to the finding that during the 30-day period between o'p-DDD administration and stress treatment, toxicant treated fish lost less weight in comparison to their sham-treated counterparts. Nutritional state did not appear to influence the performance of the charr in the present experiment, as correlations between the parameters measured and condition factor or lipid contents on an individual basis in all cases turned out non significant. Overall, the results contrast with those of previous in vivo and in vitro studies on fish, which concluded that comparable headkidney o'p-DDD levels impaired interrenal steroidogenesis. Although we conclude that the effects

  11. [Competitive pacing in a patient with DDD pacemaker and bigeminal ventricular extrasystoles].

    Science.gov (United States)

    Carbone, Vincenzo; Candelmo, Fiore; Todaro, Chiara; Oreto, Giuseppe

    2008-11-01

    The ECG recorded from a patient with DDD pacemaker showed variable responses of the pacing system to bigeminal ventricular extrasystoles, dependent on the coupling interval of premature beats. For relatively short coupling intervals, the premature spontaneous event was detected by the pacemaker, inhibiting both atrial and ventricular output, and resulting in a relatively long pacing pause. In slightly less premature end-diastolic extrasystoles, in contrast, the pacing system delivered an atrial spike that was superimposed upon the spontaneous premature QRS complex (pseudo-pseudofusion); under these circumstances, the atrial spike was followed, at the end of the programmed atrioventricular interval, by a ventricular spike falling on the extrasystolic T wave apex (competitive ventricular pacing). This phenomenon, however, did not express a sensing malfunction, but was due to post-atrial ventricular blanking (PAVB), a short period initiated by the atrial spike during which ventricular sensing is temporarily disabled, so that no signal can be detected. Finally, whenever premature end-diastolic impulses occurred after PAVB, during the brief interval defined ventricular safety pacing, the spontaneous event was sensed, being followed by an earlier-than-expected ventricular spike, whose prematurity was aimed at avoiding the occurrence of an artificial impulse upon the T wave of extrasystole. In conclusion, despite several not sensed ventricular extrasystoles and competitive pacing, no sensing malfunction was present. This case demonstrates how complex can be the electrocardiographic analysis of a DDD pacemaker, owing to the many complicating phenomena related to this pacing mechanism.

  12. Measuring Trilinear Higgs Coupling in $WHH$ and $ZHH$ Productions at the HL-LHC

    CERN Document Server

    Cao, Qing-Hong; Yan, Bin

    2015-01-01

    Determination of trilinear Higgs coupling ($\\lambda_{HHH}=\\kappa\\lambda_{HHH}^{\\rm SM}$) through Higgs pair productions is a major motivation for the LHC high luminosity phase. We perform a detailed collider simulation to explore the potential of measuring $\\lambda_{HHH}$ in the $VHH$ ($V=W,Z$) production at the HL-LHC. We find that the trilinear Higgs coupling in the SM ($\\lambda_{HHH}^{\\rm SM}$) could be measured at the level of $1.3\\sigma$. Combining with the gluon fusion, vector boson fusion and $t\\bar{t}HH$ channels, $\\lambda_{HHH}^{\\rm SM}$ is expected to be measured at the level of $3.13\\sigma$. If no evidence of Higgs pair productions were observed, the $VHH$ production, together with the gluon fusion channel, would impose a bound of $0.5\\leq \\kappa \\leq 2.2$ at the 95\\% confidence level.

  13. Pharmacokinetics of the adrenocorticolytic compounds 3-methylsulphonyl-DDE and o,p'-DDD (mitotane) in Minipigs.

    Science.gov (United States)

    Hermansson, Veronica; Cantillana, Tatiana; Hovander, Lotta; Bergman, Ake; Ljungvall, Karl; Magnusson, Ulf; Törneke, Karolina; Brandt, Ingvar

    2008-02-01

    The pharmacokinetics of the adrenocorticolytic drug candidate 3-Methylsulphonyl-DDE (3-MeSO2-DDE) and the anticancer drug o,p'-DDD (mitotane) were studied in Göttingen minipigs. The animals were given 3-MeSO2-DDE or o,p'-DDD as single oral doses (30 mg/kg). Concentrations in plasma and subcutaneous fat were measured by gas chromatography at different time points during 180 days. Maximal plasma concentrations appeared within 24 h for both compounds, but were about 2 times higher for 3-MeSO2DDE. o,p'-DDD plasma concentrations declined rapidly to low levels during 4 days. 3-MeSO2-DDE also decreased rapidly, but remained at high concentrations throughout the study. In fat, 3-MeSO2-DDE reached about 25-fold higher levels than o,p'-DDD at 30 days, and both substances were eliminated slowly from this tissue. 3-MeSO2-DDE liver concentrations were about 18-fold higher than those in plasma at 180 days. In contrast, o,p'-DDD liver and plasma levels were about equal at 180 days. o,p'-DDD had roughly 45 times larger CL/F than 3-MeSO2-DDE, confirming that the elimination of this compound was more rapid. Both compounds were characterised by their localisation and retention in fat tissue, and the individual size of the fat stores clearly determined the plasma concentrations. It is concluded that although 3-MeSO2-DDE is an interesting candidate for therapeutic use due to its potential characteristics to specifically target adrenocortical tumour cells the slow elimination of the compound might make it challenging to design appropriate dosage regimes.

  14. [Optimalization of rate adaptation using Holter functions in DDD/R pacemakers].

    Science.gov (United States)

    Novotný, T; Dvorák, R; Kozák, M; Vlasínová, J

    1998-06-01

    Introduction of the pacing rate adaptation according to the momentary metabolic needs added other programmable parametres which demand physician's attention during the initial postimplantation programmation and also in follow-up of pacemaker patients. The parametres setting is strictly individual with a need of feedback control. In some devices it is enabled by Holter functions as a part of pacemaker software. These methods were used to set the rate adaptive parametres in the group of 23 patients with implanted DDD/R pacemaker. The walking stress test was used. Model follow-up situations are presented in 3 case reports. Using Holter functions enables the physician to put patient's subjective complains in relation with actual heart rate--this is used to optimize the parametres of rate adaptation. The authors consider the Holter functions a necessary part of rate adaptive pacemaker software.

  15. 40 CFR Appendix A to Subpart Ddd... - Free Formaldehyde Analysis of Insulation Resins by the Hydroxylamine Hydrochloride Method

    Science.gov (United States)

    2010-07-01

    ... Insulation Resins by the Hydroxylamine Hydrochloride Method A Appendix A to Subpart DDD of Part 63 Protection... Part 63—Free Formaldehyde Analysis of Insulation Resins by the Hydroxylamine Hydrochloride Method 1. Scope The method in this appendix was specifically developed for water-soluble phenolic resins that...

  16. DDT, DDD, and DDE in soil of Xiangfen County, China: Residues, sources, spatial distribution, and health risks.

    Science.gov (United States)

    Ma, Jin; Pan, Li-Bo; Yang, Xiao-Yang; Liu, Xiao-Ling; Tao, Shi-Yang; Zhao, Long; Qin, Xiao-Peng; Sun, Zai-Jin; Hou, Hong; Zhou, Yong-Zhang

    2016-11-01

    We collected and analyzed 128 surface soil samples from Xiangfen County for dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethane (DDD), and dichlorodiphenyldichloroethylene (DDE). Total DDT concentrations (DDTs; sum of p,p'-DDD, p,p'-DDE, and p,p'-DDT) ranged from ND to 427.81 ng g(-1) (dry weight, dw), with a mean of 40.26 ng g(-1) (dw). Among the three compounds, p,p'-DDD was the most dominant. The DDTs in Xiangfen County soils mainly originated from historical DDT use, but there were also new inputs likely related to dicofol use. The DDTs in Xiangfen County soils were mainly degraded under anaerobic conditions, and direct degradation to DDD was the main degradation route. Regions with relatively high concentrations of DDTs were mainly located in North and South Xiangfen County. In these regions, many soil samples contained p,p'-DDT as the predominant pollutant, suggestive of extensive new inputs of DDT. A health risk assessment revealed that there are no serious long-term health impacts of exposure to DDTs in soil, for adults or children.

  17. Quantitative trait loci that control body weight and obesity in an F2 intercross between C57BL/6J and DDD.Cg-Ay mice.

    Science.gov (United States)

    Suto, Jun-ichi

    2011-07-01

    I have developed a congenic mouse strain for the A(y) allele at the agouti locus in an inbred DDD/Sgn strain, DDD.Cg-A(y). DDD.Cg-A(y) females are extremely obese and significantly heavier than B6.Cg-A(y) females. The objectives of this study were to determine the genetic basis of obesity in DDD.Cg-A(y) mice, and to determine whether or not their high body weight was due to the presence of DDD background-specific modifiers. I performed quantitative trait locus (QTL) analyses for body weight and body mass index in two types of F(2) mice [F2 A(y) (F(2) mice carrying the A(y) allele) and F(2) non-A(y) (F2 mice without the A(y) allele)] produced by crossing C57BL/6J females and DDD.Cg-A(y) males. The results of the QTL analysis of F(2) A(y) mice were very similar to those obtained for F(2) non-A(y) mice. It was unlikely that the high body weight of DDD.Cg-A(y) mice was due to the presence of specific modifiers. When both F(2) datasets were merged and analyzed, four significant body weight QTLs were identified on chromosomes 6, 9, and 17 (2 loci) and four significant obesity QTLs were identified on chromosomes 1, 6, 9, and 17. Although the presence of DDD background-specific modifiers was not confirmed, a multifactorial basis of obesity in DDD.Cg-A(y) females was thus revealed.

  18. Instrumented posterior lumbar interbody fusion (PLIF) with interbody fusion device (Cage) in degenerative disc disease (DDD): 3 years outcome.

    Science.gov (United States)

    Ahsan, M K; Hossain, M A; Sakeb, N; Khan, S I; Zaman, N

    2013-10-01

    This prospective interventional study carried out at Bangabandhu Sheikh Mujib Medical University and a private hospital in Dhaka, Bangladesh during the period from October 2003 to September 2011. Surgical treatment of degenerative disc disease (DDD) should aim to re-expand the interbody space and stabilize until fusion is complete. The present study conducted to find out the efficacy of using interbody fusion device (Cage) to achieve interbody space re-expansion and fusion in surgical management of DDD. We have performed the interventional study on 53 patients, 42 female and 11 male, with age between 40 to 67 years. All the patients were followed up for 36 to 60 months (average 48 months). Forty seven patients were with spondylolisthesis and 06 with desiccated disc. All subjects were evaluated with regard to immediate and long term complications, radiological fusion and interbody space re-expansion and maintenance. The clinical outcome (pain and disability) was scored by standard pre and postoperative questionnaires. Intrusion, extrusion and migration of the interbody fusion cage were also assessed. Forty seven patients were considered to have satisfactory outcome in at least 36 months follow up. Pseudoarthrosis developed in 04 cases and 06 patients developed complications. In this series posterior lumbar interbody fusion (PLIF) with interbody cage and instrumentation in DDD showed significant fusion rate and maintenance of interbody space. Satisfactory outcome observed in 88.68% cases.

  19. Differential effect of DDT, DDE, and DDD on COX-2 expression in the human trophoblast derived HTR-8/SVneo cells.

    Science.gov (United States)

    Dominguez-Lopez, Pablo; Diaz-Cueto, Laura; Olivares, Aleida; Ulloa-Aguirre, Alfredo; Arechavaleta-Velasco, Fabian

    2012-11-01

    The purpose of this study was to investigate the effect of 1,1,1-trichloro-2,2-bis-(chlorophenyl)ethane (DDT), 1,1-bis-(chlorophenyl)-2,2-dichloroethene (DDE), and 1,1-dichloro-2,2-bis(chlorophenyl)ethane (DDD) isomers on COX-2 expression in a human trophoblast-derived cell line. Cultured HTR-8/SVneo trophoblast cells were exposed to DDT isomers and its metabolites for 24 h, and COX-2 mRNA and protein expression were assessed by RT-PCR, Western blotting, and ELISA. Prostaglandin E₂ production was also measured by ELISA. Both COX-2 mRNA and protein were detected under control (unexposed) conditions in the HTR-8/SVneo cell line. COX-2 protein expression and prostaglandin E₂ production but not COX-2 mRNA levels increased only after DDE and DDD isomers exposure. It is concluded that DDE and DDD exposure induce the expression of COX-2 protein, leading to increased prostaglandin E2 production. Interestingly, the regulation of COX-2 by these organochlorines pesticides appears to be at the translational level.

  20. 温度植被干旱指数法(TVDI)在黄淮海平原土壤湿度反演中的应用研究%Application of Temperature-Vegetation Dryness Index (TVDI) in Estimation of Soil Moisture in the HHH Plain

    Institute of Scientific and Technical Information of China (English)

    王纯枝; 毛留喜; 何延波; 韩丽娟; 陈健; 宇振荣

    2009-01-01

    植被指数和地表温度是描述地表特征的两个重要参数,基于遥感植被指数和地表温度信息进行区域地表水分状况等陆表变化过程研究,是目前遥感和陆表过程研究中的前沿方向.利用MODIS数据产品MOD13A2和MOD11A2获取的归-化植被指数(NDVI)和地表温度(Ts),构建Ts-NDVI特征空间,依据该特征空间计算的温度植被干旱指数(TVDI)作为土壤湿度监测指标,反演了黄淮海平原2004年冬小麦4~5月份和夏玉米7~10月份每16 d的土壤湿度,并经相应的土壤湿度数据验证.结果表明:TVDI与土壤湿度显著相关(α=0.05),且反演的黄淮海平原土壤湿度的时空分布特征与农作物生育期规律、生长季总降雨量分布规律基本吻合;特别是0~10 cm、10~20 cm、20~40 cm三个土层中,TVDI更能稳定反映和指示地表10~20 cm土壤水分状况,因而TVDI方法适用于黄淮海平原作物生长季的土壤湿度动态监测.

  1. Intermolecular triple proton and deuteron transfer in crystalline 3,5-dimethylpyrazole studied by NMR, NQR, and x-ray methods

    Energy Technology Data Exchange (ETDEWEB)

    Wehrle, B.; Aguilar-Parrilla, F.; Limbach, H.H. (Universitaet Freiburg (West Germany)); de la Concepcion Foces-Foces, M.; Cano, F.H. (Instituto Rocasaolano, Madrid (Spain)); Elguero, J. (C.S.I.C., Madrid (Spain)); Baldy, A.; Pierrot, M. (Universite Aix-Marseille III (France)); Khurshid, M.M.T.; Larcombe-McDouall, J.B.; Smith, J.A.S. (King' s College, London (England))

    1989-09-13

    A combination of {sup 13}C, {sup 15}N magnetic resonance, {sup 14}N quadrupole double resonance, and x-ray studies of solid 3,5-dimethylpyrazole between 270 and 350 K has shown that the NH...N hydrogen bond units present in the crystal are dynamically disordered, so that each nitrogen atom is on average attached to half a hydrogen atom. The molecules form discrete hydrogen-bonded cyclic trimers, in which the hydrogen atoms move in a double minimum potential energy surface which is symmetrical, to within experimental error. The experimental evidence in this temperature range is consistent with disorder by means of correlated triple hydrogen jumps with an activation energy of 45 kJ mol{sup {minus}1}. There is a large kinetic hydrogen (HHH)/deuterium (DDD) isotope effort of >20 at 299 K and equal to 8 at 347 K.

  2. Lung Cancer Signature Biomarkers: tissue specific semantic similarity based clustering of Digital Differential Display (DDD data

    Directory of Open Access Journals (Sweden)

    Srivastava Mousami

    2012-11-01

    Full Text Available Abstract Background The tissue-specific Unigene Sets derived from more than one million expressed sequence tags (ESTs in the NCBI, GenBank database offers a platform for identifying significantly and differentially expressed tissue-specific genes by in-silico methods. Digital differential display (DDD rapidly creates transcription profiles based on EST comparisons and numerically calculates, as a fraction of the pool of ESTs, the relative sequence abundance of known and novel genes. However, the process of identifying the most likely tissue for a specific disease in which to search for candidate genes from the pool of differentially expressed genes remains difficult. Therefore, we have used ‘Gene Ontology semantic similarity score’ to measure the GO similarity between gene products of lung tissue-specific candidate genes from control (normal and disease (cancer sets. This semantic similarity score matrix based on hierarchical clustering represents in the form of a dendrogram. The dendrogram cluster stability was assessed by multiple bootstrapping. Multiple bootstrapping also computes a p-value for each cluster and corrects the bias of the bootstrap probability. Results Subsequent hierarchical clustering by the multiple bootstrapping method (α = 0.95 identified seven clusters. The comparative, as well as subtractive, approach revealed a set of 38 biomarkers comprising four distinct lung cancer signature biomarker clusters (panel 1–4. Further gene enrichment analysis of the four panels revealed that each panel represents a set of lung cancer linked metastasis diagnostic biomarkers (panel 1, chemotherapy/drug resistance biomarkers (panel 2, hypoxia regulated biomarkers (panel 3 and lung extra cellular matrix biomarkers (panel 4. Conclusions Expression analysis reveals that hypoxia induced lung cancer related biomarkers (panel 3, HIF and its modulating proteins (TGM2, CSNK1A1, CTNNA1, NAMPT/Visfatin, TNFRSF1A, ETS1, SRC-1, FN1, APLP2, DMBT1

  3. Lung cancer signature biomarkers: tissue specific semantic similarity based clustering of digital differential display (DDD) data.

    Science.gov (United States)

    Srivastava, Mousami; Khurana, Pankaj; Sugadev, Ragumani

    2012-11-02

    The tissue-specific Unigene Sets derived from more than one million expressed sequence tags (ESTs) in the NCBI, GenBank database offers a platform for identifying significantly and differentially expressed tissue-specific genes by in-silico methods. Digital differential display (DDD) rapidly creates transcription profiles based on EST comparisons and numerically calculates, as a fraction of the pool of ESTs, the relative sequence abundance of known and novel genes. However, the process of identifying the most likely tissue for a specific disease in which to search for candidate genes from the pool of differentially expressed genes remains difficult. Therefore, we have used 'Gene Ontology semantic similarity score' to measure the GO similarity between gene products of lung tissue-specific candidate genes from control (normal) and disease (cancer) sets. This semantic similarity score matrix based on hierarchical clustering represents in the form of a dendrogram. The dendrogram cluster stability was assessed by multiple bootstrapping. Multiple bootstrapping also computes a p-value for each cluster and corrects the bias of the bootstrap probability. Subsequent hierarchical clustering by the multiple bootstrapping method (α = 0.95) identified seven clusters. The comparative, as well as subtractive, approach revealed a set of 38 biomarkers comprising four distinct lung cancer signature biomarker clusters (panel 1-4). Further gene enrichment analysis of the four panels revealed that each panel represents a set of lung cancer linked metastasis diagnostic biomarkers (panel 1), chemotherapy/drug resistance biomarkers (panel 2), hypoxia regulated biomarkers (panel 3) and lung extra cellular matrix biomarkers (panel 4). Expression analysis reveals that hypoxia induced lung cancer related biomarkers (panel 3), HIF and its modulating proteins (TGM2, CSNK1A1, CTNNA1, NAMPT/Visfatin, TNFRSF1A, ETS1, SRC-1, FN1, APLP2, DMBT1/SAG, AIB1 and AZIN1) are significantly down regulated

  4. Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the A(y) allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss.

    Science.gov (United States)

    Suto, Jun-ichi; Satou, Kunio

    2013-05-04

    Mice carrying the A(y) allele at the agouti locus become obese and are heavier than their non-A(y) littermates. However, this does not hold true for the genetic background of the DDD mouse strain. At 22 weeks of age, DDD.Cg-A(y) females are heavier than DDD females, whereas DDD.Cg-A(y) males are lighter than DDD males. This study aimed to determine the possible cause and identify the genes responsible for the lower body weight of DDD.Cg-A(y) males. Growth curves of DDD.Cg-A(y) mice were analyzed and compared with those of B6.Cg-A(y) mice from 5 to 25 weeks. In DDD.Cg-A(y) males, body weight gain stopped between 16 and 17 weeks and the body weight gradually decreased; thus, the lower body weight was a consequence of body weight loss. Quantitative trait locus (QTL) mapping was performed in backcrossed (BC) males of DDD × (B6 × DDD.Cg-A(y)) F(1)-A(y) mice. For the body weight at 25 weeks, significant QTLs were identified on chromosomes 1 and 4. The DDD allele was associated with a lower body weight at both loci. In particular, the QTL on chromosome 4 interacted with the A(y) allele. Furthermore, suggestive QTLs for plasma glucose and high molecular weight adiponectin levels were coincidentally mapped to chromosome 4. The DDD allele was associated with increased glucose and decreased adiponectin levels. When the body weight at 25 weeks and plasma glucose levels were considered as dependent and independent variables, respectively, BC A(y) males were classified into two groups according to statistical analysis using the partition method. Mice of one group had significantly higher glucose and lower adiponectin levels than those of the other group and exhibited body weight loss as observed with DDD-A(y) males. The lower body weight of DDD.Cg-A(y) male mice was a consequence of body weight loss. Diabetes mellitus has been suggested to be a possible contributory factor causing body weight loss. The QTL on distal chromosome 4 contained the major responsible genes. This QTL

  5. A prolonged course of Group A streptococcus-associated nephritis: a mild case of dense deposit disease (DDD)?

    Science.gov (United States)

    Sawanobori, E; Umino, A; Kanai, H; Matsushita, K; Iwasa, S; Kitamura, H; Oda, T; Yoshizawa, N; Sugita, K; Higashida, K

    2009-06-01

    We herein report the case of a 12-year-old boy with dense deposit disease (DDD) evoked by streptococcal infection. He had been diagnosed to have asymptomatic hematuria syndrome at the age of 6 during school screening. At 12 years of age, he was found to have macrohematuria and overt proteinuria with hypocomplementemia 2 months after streptococcal pharyngitis. Renal biopsy showed endocapillary proliferative glomerulonephritis with double contours of the glomerular basement membrane. Hypocomplementemia and proteinuria were sustained for over 8 weeks. He was suspected to have dense deposit disease due to intramembranous deposits in the first and the second biopsies. 1 month after treatment with methylprednisolone pulse therapy, proteinuria decreased to a normal level. Microscopic hematuria disappeared 2 years later, but mild hypocomplementemia persisted for more than 7 years. Nephritis-associated plasmin receptor (NAPlr), a nephritic antigen for acute poststreptococcal glomerulonephritis, was found to be positive in the glomeruli for more than 8 weeks. DDD is suggested to be caused by dysgeneration of the alternative pathway due to C3NeF and impaired Factor H activity. A persistent deposition of NAPlr might be one of the factors which lead to complement dysgeneration. A close relationship was suggested to exist between the streptococcal infection and dense deposit disease in this case.

  6. Ambulatory Holter monitoring in asymptomatic patients with DDD pacemakers - do we need ACC/AHA Guidelines revision?

    Science.gov (United States)

    Chudzik, Michal; Klimczak, Artur; Wranicz, Jerzy Krzysztof

    2013-10-31

    We sought to determine the usefulness of ambulatory 24-hour Holter monitoring in detecting asymptomatic pacemaker (PM) malfunction episodes in patients with dual-chamber pacemakers whose pacing and sensing parameters were proper, as seen in routine post-implantation follow-ups. Ambulatory 24-hour Holter recordings (HM) were performed in 100 patients with DDD pacemakers 1 day after the implantation. Only asymptomatic patients with proper pacing and sensing parameters (assessed on PM telemetry on the first day post-implantation) were enrolled in the study. The following parameters were assessed: failure to pace, failure to sense (both oversensing and undersensing episodes) as well as the percentage of all PM disturbances. Despite proper sensing and pacing parameters, HM revealed PM disturbances in 23 patients out of 100 (23%). Atrial undersensing episodes were found in 12 patients (p < 0.005) with totally 963 episodes and failure to capture in 1 patient (1%). T wave oversensing was the most common ventricular channel disorder (1316 episodes in 9 patients, p < 0.0005). Malfunction episodes occurred sporadically, leading to pauses of up to 1.6 s or temporary bradycardia, which were, nevertheless, not accompanied by clinical symptoms. No ventricular pacing disturbances were found. Asymptomatic pacemaker dysfunction may be observed in nearly 25% of patients with proper DDD parameters after implantation. Thus, ambulatory HM during the early post-implantation period may be a useful tool to detect the need to reprogram PM parameters.

  7. Dicty_cDB: AFH258 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 6. 2 Translated Amino Acid sequence gllxskinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkilmilk...vrqfqs*wvlinckl*iqsmvgfhqrcnkqimilkscllvf ywvplmhl*fgkvqerpq*fvdslkihfgvnkiisssirhqaqvmnisplsil*nlvipm vqyws...*nkkkl* Frame B: gllxskinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkilmilkq* hhh*SQNPLVAVLVKINHHHHHHVVVVVIK

  8. Data of evolutionary structure change: 1BVUE-1HRDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1BVUE-1HRDA 1BVU 1HRD E A QDPFEIAVKQLE---------------RAAQYMDISEEA...EVITKKNADNI---KAKIVAELANGPTTPEADEILYEKG-ILIIPDFLCNAGGVTVSYFEWVQNITGDYWTVEETRAKLDKKMTKAFWDVYNTHKEKNIN--MRDAAY...1BVUE EKNIN--MRDAA H --HHHHH 1HRD A 1HRDA... 1HRDA RKIVG--GFYNG HHH --

  9. 75 FR 19409 - Request for Comment on Minimum Requirements for Criteria in Fiscal Year 2011 Grant Applications...

    Science.gov (United States)

    2010-04-14

    ... health records is dynamic. The Administrator understands that there are several initiatives being... addressed can be viewed by searching ``HHH-OS-2009-0006'' at the http://www.regulations.gov website....

  10. Dicty_cDB: AFH252 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available i*kilaiilkkllfnhqkkqlql*ynkilmilkq*hhh* sqnplvavlvkinhhhhhhvvvvviklkknknqvvvvvvkvnhhhhvvvviiinlkknkn qvvveem...ikrvlk le*kllkiryw*chqrvvlvnqqfhpcyhmvfqreiitppkyly*mlifavrqfqs*wvl inckl*iqsmvgfhqrcnkqimilk...CSSCPGQNACKSQADNPDKKSIEI RMKVIKNKILVMSSKGGVGKSTVSSLLSYGFSKRNNNTTKVSVLDVDICGPSIPKLMGVD KLQIINSEYGWIPPKVQQANHDIKVMSV--- ---rcnkqimilk...IPPKVQQANHDIKVMSV--- ---KVQQANHDIKVMSVGFLLGTPDAPVIWKGPRKTTMIRRFLKDTFWGKQDYLIIDTPP GTSDEHLSIINSLKSCNPDGAVLVTT...hhqsicirc*ylrsvnskangc* *ianykfrvwldstkgatsks*y*shvc--- ---KVQQANHDIKVMSVGFLLGTPDAPVIWKGPRKTTMIR

  11. Dicty_cDB: VFL193 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available e B: gllekhlkkskkinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkil milkq*hhh*sqnplvavlvkinhhhhhhvvvvviklkknkn...***s*rktkirllwr**kkwiiiml*irind nnnnnk*tnkr*fkyfikw--- ---qfqs*wvlinckl*iqsmvgfhqrcnkqimilkscllvfywvplmhl*fg...MGVDKLQIINSEYGWIPPKVQQANHDIKVMSVGFLLGTPDAPVIWKGPRKTT MIRRFLKDTFWGKQDYLIIDTPPGTSDEHLSIINSLKSCNPDGAVLVTTPQDLSC...PKLMGVDKLQIINSEYGWIPPKVQQANHDIKVMSVGFLLGTPDAPVIWKGPRKTT MIRRFLKDTFWGKQDYLIIDTPPGT

  12. Density dependence of clutch size: habitat heterogeneity or individual adjustment?

    NARCIS (Netherlands)

    Both, C.

    1998-01-01

    1. Two hypotheses have been proposed to explain density- dependent patterns in reproduction. The habitat heterogeneity hypothesis (HHH) explains density-dependent reproduction at the population level from poorer quality territories in heterogeneous environments only being occupied at high densities.

  13. Data of evolutionary structure change: 1LFQA-1RQAB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1LFQA-1RQAB 1LFQ 1RQA A B -VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPT...HCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH - HHHHHHHHHH...ex>0 1RQA B 1RQAB A 1LFQA WGKVGAHAGEYG HHH

  14. Genetics Home Reference: ornithine translocase deficiency

    Science.gov (United States)

    ... Diagnosis of Japanese patients with HHH syndrome by molecular genetic analysis: a common mutation, R179X. J Hum Genet. ... Accessibility FOIA Viewers & Players U.S. Department of Health & Human Services National Institutes of Health National Library of ...

  15. Data of evolutionary structure change: 1BINA-2OIFE [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1BINA-2OIFE 1BIN 2OIF A E VAFTEKQDALVSSSFEAFKANIPQYSVVFYTSILEKAPA...KKA--- VVFSEEKEALVLKSWAIMKKDSANLGLRFFLKIFEIAPSARQMFPFLRDSDVPLETNPKLKTHAVSVFVMTCEAAAQLRKAGKITVRE...in>E 2OIFE PFLRDSDVPLET HH.../entryChain> 2OIF E 2OIFE 2OIFE ALPADMWGPEM H HHH

  16. Deconstructing the mammal species richness pattern in Europe - towards and understanding of the relative importance of climate, biogeographic history, habitat heterogeneity and humans

    DEFF Research Database (Denmark)

    Fløjgaard, Camilla; Normand, Signe; Skov, Flemming;

    2011-01-01

    Aim  We deconstructed the mammal species richness pattern in Europe to assess the importance of large-scale gradients in current macroclimate relative to biogeographic history, habitat heterogeneity and human influence (HHH variables) as richness determinants for total species, and for widespread...... partitioning to assess the importance of macroclimate and HHH variables. The HHH variables included two historical factors, estimated by novel methodologies: (1) ice-age-driven dynamics, represented by accessibility to recolonization from hindcasting-estimated glacial refugia, and (2) biogeographic peninsular...... dynamics, represented by distance to the entry region for the main European faunal source in western Asia. Results  A large fraction of explained variation was shared between macroclimate and HHH in the SAR models. For total species richness, more variation could be uniquely attributed to macroclimate than...

  17. 40 CFR 147.151 - EPA-administered program.

    Science.gov (United States)

    2010-07-01

    ... requirements contained in subpart HHH of this part. The program for all injection activity except that on Navajo Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  18. 77 FR 58537 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Science.gov (United States)

    2012-09-21

    ... according to the procedures prescribed in 5 CFR 1320.12. On May 9, 2011 (76 FR 26900) EPA sought comments on.../Infectious Waste Incinerators, (40 CFR part 60, subpart Ce, and 40 CFR part 62, subpart HHH). Owners...

  19. 42 CFR Appendix to Subpart B of... - Required Consent Form

    Science.gov (United States)

    2010-10-01

    ... CFR part 50, subpart B, relating to the sterilization of persons in federally assisted public health... Clearance Officer, ASBTF/Budget Room 503 HHH Building, 200 Independence Avenue, SW., Washington, DC...

  20. 77 FR 70751 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Science.gov (United States)

    2012-11-27

    ... prescribed in 5 CFR 1320.12. On August 9, 2012 (77 FR 47631), EPA sought comments on this ICR pursuant to 5... the Provisions specified at 40 CFR part 60, subpart HHH. Owners or operators of the...

  1. 40 CFR 147.2253 - EPA-administered program-Indian lands.

    Science.gov (United States)

    2010-07-01

    ... Mountain Ute consists of the requirements set forth at subpart HHH of this part. The program for all other wells on Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148,...

  2. Data of evolutionary structure change: 3DLSB-3DLSF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 3DLSB-3DLSF 3DLS 3DLS B F AVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE...KNKEVVVKFIKKE--WIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDE...NKEVVVKFIKKEKVWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDEN...HHH GGG HHHH - 0 3DLS B 3DLSB FIKKE--WIEDP

  3. Data of evolutionary structure change: 1D5NA-1UNFX [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 830719470977783 EVID>EVID> 1 1UNF A X ----SYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYV...NNANAALESL----PEFANLPVEELITKLDQLPADKKTVL---------RNNAGGHANHSLFWKGLKKGTT--LQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGW...HHH EVID> 0 TRP CA 375 1UNF X 1UNF

  4. Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the Ay allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss

    Science.gov (United States)

    2013-01-01

    Background Mice carrying the Ay allele at the agouti locus become obese and are heavier than their non-Ay littermates. However, this does not hold true for the genetic background of the DDD mouse strain. At 22 weeks of age, DDD.Cg-Ay females are heavier than DDD females, whereas DDD.Cg-Ay males are lighter than DDD males. This study aimed to determine the possible cause and identify the genes responsible for the lower body weight of DDD.Cg-Ay males. Results Growth curves of DDD.Cg-Ay mice were analyzed and compared with those of B6.Cg-Ay mice from 5 to 25 weeks. In DDD.Cg-Ay males, body weight gain stopped between 16 and 17 weeks and the body weight gradually decreased; thus, the lower body weight was a consequence of body weight loss. Quantitative trait locus (QTL) mapping was performed in backcrossed (BC) males of DDD × (B6 × DDD.Cg-Ay) F1-Ay mice. For the body weight at 25 weeks, significant QTLs were identified on chromosomes 1 and 4. The DDD allele was associated with a lower body weight at both loci. In particular, the QTL on chromosome 4 interacted with the Ay allele. Furthermore, suggestive QTLs for plasma glucose and high molecular weight adiponectin levels were coincidentally mapped to chromosome 4. The DDD allele was associated with increased glucose and decreased adiponectin levels. When the body weight at 25 weeks and plasma glucose levels were considered as dependent and independent variables, respectively, BC Ay males were classified into two groups according to statistical analysis using the partition method. Mice of one group had significantly higher glucose and lower adiponectin levels than those of the other group and exhibited body weight loss as observed with DDD-Ay males. Conclusions The lower body weight of DDD.Cg-Ay male mice was a consequence of body weight loss. Diabetes mellitus has been suggested to be a possible contributory factor causing body weight loss. The QTL on distal chromosome 4 contained the major responsible genes

  5. The Magic Background of Pearl Harbor. Volume 5

    Science.gov (United States)

    1978-01-01

    British Imperial Bank III, 381 Brooke, Alan , British General IV, 383 Brooke-Popham, Sir Robert, British Commander in the Far East 11,288 III, 429 Brooks...h h _n- 11,96 President Taylor, U.S. ship h__n_h_hhh_n-hhh__h_hhnhhh_nhh III, 136, 193,217 Prieto , Indalecion, Spanish ex-Minister, head of Aid to

  6. PLASMA-LEVEL MONITORING OF MITOTANE (O,P'-DDD) AND ITS METABOLITE (O,P'-DDE) DURING LONG-TERM TREATMENT OF CUSHINGS-DISEASE WITH LOW-DOSES

    NARCIS (Netherlands)

    BENECKE, R; KELLER, E; VETTER, B; DEZEEUW, RA

    1991-01-01

    Mitotane (o,p'-DDD) can be used for the treatment of various adrenocortical diseases such as Cushing's syndrome, but the usual doses of 6-8 g per day are often associated with severe adverse effects. This paper reports the results of much lower doses of o.p'-DDD (0.5-2 g per day) in two patients wit

  7. Methanopyrus kandleri topoisomerase V contains three distinct AP lyase active sites in addition to the topoisomerase active site.

    Science.gov (United States)

    Rajan, Rakhi; Osterman, Amy; Mondragón, Alfonso

    2016-04-20

    Topoisomerase V (Topo-V) is the only topoisomerase with both topoisomerase and DNA repair activities. The topoisomerase activity is conferred by a small alpha-helical domain, whereas the AP lyase activity is found in a region formed by 12 tandem helix-hairpin-helix ((HhH)2) domains. Although it was known that Topo-V has multiple repair sites, only one had been mapped. Here, we show that Topo-V has three AP lyase sites. The atomic structure and Small Angle X-ray Scattering studies of a 97 kDa fragment spanning the topoisomerase and 10 (HhH)2 domains reveal that the (HhH)2 domains extend away from the topoisomerase domain. A combination of biochemical and structural observations allow the mapping of the second repair site to the junction of the 9th and 10th (HhH)2 domains. The second site is structurally similar to the first one and to the sites found in other AP lyases. The 3rd AP lyase site is located in the 12th (HhH)2 domain. The results show that Topo-V is an unusual protein: it is the only known protein with more than one (HhH)2 domain, the only known topoisomerase with dual activities and is also unique by having three AP lyase repair sites in the same polypeptide.

  8. The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition.

    Science.gov (United States)

    Wienk, Hans; Slootweg, Jack C; Speerstra, Sietske; Kaptein, Robert; Boelens, Rolf; Folkers, Gert E

    2013-07-01

    To maintain the integrity of the genome, multiple DNA repair systems exist to repair damaged DNA. Recognition of altered DNA, including bulky adducts, pyrimidine dimers and interstrand crosslinks (ICL), partially depends on proteins containing helix-hairpin-helix (HhH) domains. To understand how ICL is specifically recognized by the Fanconi anemia proteins FANCM and FAAP24, we determined the structure of the HhH domain of FAAP24. Although it resembles other HhH domains, the FAAP24 domain contains a canonical hairpin motif followed by distorted motif. The HhH domain can bind various DNA substrates; using nuclear magnetic resonance titration experiments, we demonstrate that the canonical HhH motif is required for double-stranded DNA (dsDNA) binding, whereas the unstructured N-terminus can interact with single-stranded DNA. Both DNA binding surfaces are used for binding to ICL-like single/double-strand junction-containing DNA substrates. A structural model for FAAP24 bound to dsDNA has been made based on homology with the translesion polymerase iota. Site-directed mutagenesis, sequence conservation and charge distribution support the dsDNA-binding model. Analogous to other HhH domain-containing proteins, we suggest that multiple FAAP24 regions together contribute to binding to single/double-strand junction, which could contribute to specificity in ICL DNA recognition.

  9. Enantioselective induction of cytotoxicity by o,p'-DDD in PC12 cells: implications of chirality in risk assessment of POPs metabolites.

    Science.gov (United States)

    Wang, Cui; Li, Zhuoyu; Zhang, Quan; Zhao, Meirong; Liu, Weiping

    2013-04-16

    The increased release of chiral persistent organic pollutants (POPs) into the environment has resulted in more attention to the role of enantioselectivity in the fate and ecotoxicological effects of these compounds. Although the enantioselectivity of chiral POPs has been considered in previous studies, little effort has been expended to discern the enantiospecific effects of chiral POPs metabolites, which may impede comprehensive risk assessments of these chemicals. In the present study, o,p'-DDD, the chiral metabolite of o,p'-DDT, was used as a model chiral metabolite. First, a preferential chiral separation at 100% ethanol was employed to obtain a pure enantiomer. The enantioselective cytotoxicity of o,p'-DDD in rat cells (PC12) was evaluated by detecting activation of the cellular apoptosis and oxidative stress systems and microarray analysis. We have documented for the first time that R-(+)-o,p'-DDD increases apoptosis by selectively disturbing the oxidative system (enzymes and molecules) and regulating the transcription of Aven, Bid, Cideb and Tp53. By comparing the data from the present study to data derived from the parent compound, we concluded that the R-enantiomer is the more detrimental stereostructure for both o,p'-DDT and o,p'-DDD. This observed stereostructural effect is in line with the structure-activity relationship formulated at other structural levels. Biological activities of the chiral metabolites are likely to occur in the same absolute configuration between chiral POPs and their metabolites provided that they have the similar stereostructures.

  10. Cytochrome P450-catalyzed binding of 3-methylsulfonyl-DDE and o,p'-DDD in human adrenal zona fasciculata/reticularis.

    Science.gov (United States)

    Lindhe, Orjan; Skogseid, Britt; Brandt, Ingvar

    2002-03-01

    3-Methylsulfonyl-2,2'-bis(4-chlorophenyl)-1,1'-dichloroethene (MeSO(2)-DDE) is a potent, tissue-specific toxicant that induces necrosis of the adrenal zona fasciculata following a local CYP11B1-catalyzed activation to a reactive intermediate in mice. Autoradiography was used to examine CYP11B1-catalyzed binding of MeSO(2)-[(14)C]DDE and the adrenocorticolytic drug 2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichlorethane; (o,p'-[(14)C]DDD, Mitotane, Lysodren) in human adrenal tissue slice culture. Both compounds gave rise to a selective binding in the one sample of normal adrenal zona fasciculata/reticularis, leaving zona glomerulosa and the adrenal medulla devoid of binding. Addition of the CYP11B1 selective inhibitor metyrapone (50 microM) reduced MeSO(2)-[(14)C]DDE binding below the detection limit, whereas o,p'-[(14)C]DDD binding was reduced only by 42%. Selective binding of MeSO(2)-[(14)C]DDE and o,p'-[(14)C]DDD was also observed in an aldosterone-producing adrenocortical carcinoma and in a nonfunctional adrenocortical hyperplasia. Exposure of slices from the normal adrenal cortex to MeSO(2)-DDE (25 microM) resulted in an increased accumulation of 11-deoxycorticosterone, 11-deoxycortisol and androstenedione in the medium, and exposure to o,p'-DDD (25 microM) did not alter the steroid secretion pattern. No histological changes were found in either MeSO(2)-DDE- or o,p'-DDD-exposed slices, compared with nonexposed slices. We suggest that MeSO(2)-DDE might act as a potent adrenocorticolytic agent in humans. Further studies are needed to establish the usefulness of MeSO(2)-DDE as a possible alternative for the treatment of adrenocortical hypersecretion and tumor growth.

  11. Comparative CYP-dependent binding of the adrenocortical toxicants 3-methylsulfonyl-DDE and o,p'-DDD in Y-1 adrenal cells.

    Science.gov (United States)

    Hermansson, Veronica; Asp, Vendela; Bergman, Ake; Bergström, Ulrika; Brandt, Ingvar

    2007-11-01

    The environmental pollutant 3-MeSO(2)-DDE [2-(3-methylsulfonyl-4-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethene] is an adrenocortical toxicant in mice, specifically in the glucocorticoid-producing zona fasciculata, due to a cytochrome P450 11B1 (CYP11B1)-catalysed bioactivation and formation of covalently bound protein adducts. o,p'-DDD [2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane] is toxic and inhibits steroidogenesis in the human adrenal cortex after bioactivation by unidentified CYPs, but does not exert any toxic effects on the mouse adrenal. As a step towards determining in vitro/in vivo relationships for the CYP-catalysed binding and toxicity of 3-MeSO(2)-DDE and o,p'-DDD, we have investigated the irreversible protein binding of these two toxicants in the murine adrenocortical cell line Y-1. The irreversible binding of 3-MeSO(2)-DDE previously demonstrated in vivo was successfully reproduced and could be inhibited by the CYP-inhibitors etomidate, ketoconazole and metyrapone. Surprisingly, o,p'-DDD reached similar levels of binding as 3-MeSO(2)-DDE. The binding of o,p'-DDD was sensitive to etomidate and ketoconazole, but not to metyrapone. Moreover, GSH depletion increased the binding of 3-MeSO(2)-DDE, but not of o,p'-DDD, indicating an important role of GSH conjugation in the detoxification of the 3-MeSO(2)-DDE-derived reactive metabolite. In addition, the specificity of CYP11B1 in activating 3-MeSO(2)-DDE was investigated using structurally analogous compounds. None of the analogues produced histopathological lesions in the mouse adrenal in vivo following a single i.p. injection of 100 mg/kg body weight, but two of the compounds were able to decrease the irreversible binding of 3-MeSO(2)-DDE to Y-1 cells. These results indicate that the bioactivation of 3-MeSO(2)-DDE by CYP11B1 is highly structure-dependent. In conclusion, both 3-MeSO(2)-DDE and o,p'-DDD bind irreversibly to Y-1 cells despite differences in binding and adrenotoxicity in mice

  12. 初探松下DDD--松下TC一50LC10D数字全驱显像电视分析

    Institute of Scientific and Technical Information of China (English)

    刘晔

    2004-01-01

    @@ 早在去年5月,松下就已经推出了一款"数字全驱显像电视"45LC1 2,在业界全力推广真正的数字电视.时隔一年,笔者近日在检索"青岛·中国国际家电电子博览会"(6月1 8-21日,青岛国际会展中心)有关资料的时候,发现了松下参展的数字电视里面,把"数字全驱显像电视"列作"DDD"类别--与PDP和LCD等列,不难发现,松下是力图要把自己的"DDD"产品与当下的普通的PDP与LCD区别开来.

  13. Study of DDT and its derivatives DDD, DDE adsorption and degradation over Fe-SBA-15 at low temperature.

    Science.gov (United States)

    Wang, Hailin; Tian, Hua; Hao, Zhengping

    2012-01-01

    Mesoporous SBA-15 with different Fe2O3 loading were synthesized by an in-situ coating progress for removals of dichlorodiphenyltrichloroethane (DDT) and its derivatives, i.e., 1,1-dichloro-2,2-bis-(p-chlorophenyl)ethane (DDD) and 1,1-dichloro-2,2-bis-(4-chloro -phenyl) ethane (DDE). The results from XRD (X-ray diffractometer), TEM (transmission electron microscopy) indicated that the iron could be well dispersed on SBA-15 within 6 wt.% Fe2O3 loading. Nitrogen adsorption-desorption tests indicated that the synthesized materials were characterized by ordered meso-structure, high surface area and large pore volume. DDTs were removed from aqueous media in 12-hr treatment and high removal efficiency of DDTs was achieved at over 94%. DDTs could be completely degraded at 350 degrees C under the existence of SBA-15 with 4 wt.% Fe2O3 loading. The final degradation products of DDT were dichlorobenzophenone (DCB) and bis-(4-chloro-phenyl) methane (DDM), suggesting a complete dechlorination from trichloromethyl.

  14. Study of DDT and its derivatives DDD, DDE adsorption and degradation over Fe-SBA-15 at low temperature

    Institute of Scientific and Technical Information of China (English)

    Hailin Wang; Hua Tian; Zhengping Hao

    2012-01-01

    Mesoporous SBA-15 with different Fe2O3 loading were synthesized by an in-situ coating progress for removals of dichlorodiphenyltrichloroethane(DDT)and its derivatives,i.e.,1,1-dichloro-2,2-bis-(p-chlorophenyl)ethane(DDD)and 1,l-dichloro-2,2-bis-(4-chloro -phenyl)ethane(DDE).The results from XRD(X-ray diffractometer),TEM(transmission electron microscopy)indicated that the iron could be well dispersed on SBA-15 within 6 wt.% Fe2O3 loading.Nitrogen adsorption-desorption tests indicated that the synthesized materials were characterized by ordered meso-structure,high surface area and large pore volume.DDTs were removed from aqueous media in 12-hr treatment and high removal efficiency of DDTs was achieved at over 94%.DDTs could be completely degraded at 350℃ under the existence of SBA-15 with 4 wt.% Fe2O3 loading.The final degradation products of DDT were dichlorobenzophenone (DCB)and bis-(4-chloro-phenyl)methane(DDM),suggesting a complete dechlorination from trichloromethyl.

  15. Use of the p,p'-DDD: p,p'-DDE concentration ratio to trace contaminant migration from a hazardous waste site.

    Science.gov (United States)

    Pinkney, Alfred E; McGowan, Peter C

    2006-09-01

    For approximately 50 years, beginning in the 1920s, hazardous wastes were disposed in an 11-hectare area of the Marine Corps Base (MCB) Quantico, Virginia, USA known as the Old Landfill. Polychlorinated biphenyls (PCBs) and DDT compounds were the primary contaminants of concern. These contaminants migrated into the sediments of a 78-hectare area of the Potomac River, the Quantico Embayment. Fish tissue contamination resulted in the MCB posting signs along the embayment shoreline warning fishermen to avoid consumption. In this paper, we interpret total PCB (t-PCBs) and total DDT (t-DDT, sum of six DDT, DDD, and DDE isomers) data from monitoring studies. We use the ratio of p,p'-DDD to p,p'-DDE concentrations as a tracer to distinguish site-related from regional contamination. The median DDD/DDE ratio in Quantico Embayment sediments (3.5) was significantly higher than the median ratio (0.71) in sediments from nearby Powells Creek, used as a reference area. In general, t-PCBs and t-DDT concentrations were significantly higher in killifish (Fundulus diaphanus) and carp (Cyprinus carpio) from the Quantico Embayment compared with Powells Creek. For both species, Quantico Embayment fish had mean or median DDD/DDE ratios greater than one. Median ratios were significantly higher in Quantico Embayment (4.6) than Powells Creek (0.28) whole body carp. In contrast, t-PCBs and t-DDT in channel catfish (Ictalurus punctatus) fillets were similar in Quantico Embayment and Powells Creek collections, with median ratios of 0.34 and 0.26, respectively. Differences between species may be attributable to movement (carp and killifish being more localized) and feeding patterns (carp ingesting sediment while feeding). We recommend that environmental scientists use this ratio when investigating sites with DDT contamination.

  16. Quantitative trait loci that control plasma lipid levels in an F2 intercross between C57BL/6J and DDD.Cg-A(y) inbred mouse strains.

    Science.gov (United States)

    Suto, Jun-ichi

    2012-04-01

    The objectives of this study were to characterize plasma lipid phenotypes and dissect the genetic basis of plasma lipid levels in an obese DDD.Cg-A(y) mouse strain. Plasma triglyceride (TG) levels were significantly higher in the DDD.Cg-A(y) strain than in the B6.Cg-A(y) strain. In contrast, plasma total-cholesterol (CHO) levels did not substantially differ between the two strains. As a rule, the A(y) allele significantly increased TG levels, but did not increase CHO levels. Quantitative trait locus (QTL) analyses for plasma TG and CHO levels were performed in two types of F(2) female mice [F(2)A(y) (F(2) mice carrying the A(y) allele) and F(2) non- A(y) mice (F(2) mice without the A(y) allele)] produced by crossing C57BL/6J females and DDD.Cg-A(y) males. Single QTL scan identified one significant QTL for TG levels on chromosome 1, and two significant QTLs for CHO levels on chromosomes 1 and 8. When the marker nearest to the QTL on chromosome 1 was used as covariates, four additional significant QTLs for CHO levels were identified on chromosomes 5, 6, and 17 (two loci). In contrast, consideration of the agouti locus genotype as covariates did not detect additional QTLs. DDD.Cg-A(y) showed a low CHO level, although it had Apoa2(b), which was a CHO-increasing allele at the Apoa2 locus. This may have been partly due to the presence of multiple QTLs, which were associated with decreased CHO levels, on chromosome 8.

  17. Occurrences and fate of DDT principal isomers/metabolites, DDA, and o,p'-DDD enantiomers in fish, sediment and water at a DDT-impacted Superfund site.

    Science.gov (United States)

    Garrison, A W; Cyterski, M; Roberts, K D; Burdette, D; Williamson, J; Avants, J K

    2014-11-01

    In the 1950s and 60s, discharges from a DDT manufacturing plant contaminated a tributary system of the Tennessee River near Huntsville, Alabama, USA. Regulatory action resulted in declaring the area a Superfund site which required remediation and extensive monitoring. Monitoring data collected from 1988, after remediation, through 2011 showed annual decreases approximating first-order decay in concentrations of total DDT and its six principal congeners (p,p'-DDT, o,p'-DDT, p,p'-DDD, o,p'-DDD, p,p'-DDE and o,p'-DDE) in filets from three species of fish. As of 2013, these concentrations met the regulatory requirements of 5 mg/kg or less total DDT for each fish tested. The enantiomer fractions (EF) of chiral o,p'-DDD in smallmouth buffalo and channel catfish were always below 0.5, indicating preferential decay of the (+)-enantiomer of this congener; this EF did not change significantly over 15 years. The often-neglected DDT metabolite p,p'-DDA was found at a concentration of about 20 μg/l in the ecosystem water.

  18. Feasibility of dual-chamber (DDD) pacing via a single-pass (VDD) pacing lead employing a floating atrial ring (dipole): case series, future considerations, and refinements.

    Science.gov (United States)

    Kassotis, John; Voigt, Louis; Mongwa, Mbu; Reddy, C V R

    2005-01-01

    The objective of this study was to assess the feasibility of DDD pacing from a standard single-pass VDD pacemaker system. Over the past 2 decades significant advances have been made in the development of single-pass VDD pacing systems. These have been shown in long-term prospective studies to effectively preserve atrioventricular (AV)synchrony in patients with AV block and normal sinus node function. What remains problematic is the development of a single-pass pacing system capable of DDD pacing. Such a lead configuration would be useful in those patients with peripheral venous anomalies and in younger patients with congenital anomalies, which may require lead revisions in the future. In addition, with the increased use of resynchronization (biventricular pacing) therapy, the availability of a reliable single-pass lead will minimize operative time, enhance patient safety, and minimize the amount of hardware within the heart. The feasibility of DDD pacing via a Medtronic Capsure VDD-2 (Model #5038) pacing lead was evaluated. Twenty patients who presented with AV block and normal sinus node function were recruited for this study. Atrial pacing thresholds and sensitivities were assessed intraoperatively in the supine position with various respiratory maneuvers. Five patients who agreed to participate in long-term follow-up received a dual-chamber generator and were evaluated periodically over a 12-month period. Mean atrial sensitivity was 2.35 +/- 0.83 mV at the time of implantation. Effective atrial stimulation was possible in all patients at the time of implantation (mean stimulation threshold 3.08 +/- 1.04 V at 0.5 ms [bipolar], 3.34 +/- 0.95 V at 0.5 ms [unipolar]). Five of the 20 patients received a Kappa KDR701 generator, and atrial electrical properties were followed up over a 1-year period. There was no significant change in atrial pacing threshold or incidence of phrenic nerve stimulation over the 1-year follow-up. A standard single-pass VDD pacing lead

  19. Quantitative trait locus mapping of genes associated with vacuolation in the adrenal X-zone of the DDD/Sgn inbred mouse

    Directory of Open Access Journals (Sweden)

    Suto Jun-ichi

    2012-11-01

    Full Text Available Abstract Background Adrenal gland of mice contains a transient zone between the adrenal cortex and the adrenal medulla: the X-zone. There are clear strain differences in terms of X-zone morphology. Nulliparous females of the inbred mouse DDD strain develop adrenal X-zones containing exclusively vacuolated cells, whereas females of the inbred mouse B6 strain develop X-zones containing only non-vacuolated cells. The X-zone vacuolation is a physiologic process associated with the X-zone degeneration and is tightly regulated by genetic factors. Identification of the genetic factors controlling such strain differences should help analyze the X-zone function. In this study, a quantitative trait locus (QTL analysis for the extent of X-zone vacuolation was performed for two types of F2 female mice: F2Ay mice (F2 mice with the Ay allele and F2 non-Ay mice (F2 mice without the Ay allele. These were produced by crossing B6 females and DDD.Cg-Ay males. DDD.Cg-Ay is a congenic mouse strain for the Ay allele at the agouti locus and is used for this study because a close association between the X-zone morphology and the agouti locus genotype has been suggested. The Ay allele is dominant and homozygous lethal; therefore, living Ay mice are invariably heterozygotes. Results Single QTL scans identified significant QTLs on chromosomes 1, 2, 6, and X for F2 non-Ay mice, and on chromosomes 2, 6, and 12 for F2Ay mice. The QTL on chromosome 2 was considered to be because of the agouti locus, which has been suggested to be associated with X-zone vacuolation. A significant QTL that interacted with the agouti locus was identified on chromosome 8. Conclusions The extent of X-zone vacuolation in DDD females was controlled by multiple genes with complex interactions. The murine X-zone is considered analogous structure to the human fetal zone. Therefore, the results of this study will aid in understanding function of not only of the X-zone but also of the human fetal zone

  20. Quantitative trait locus mapping of genes associated with vacuolation in the adrenal X-zone of the DDD/Sgn inbred mouse.

    Science.gov (United States)

    Suto, Jun-Ichi

    2012-11-06

    Adrenal gland of mice contains a transient zone between the adrenal cortex and the adrenal medulla: the X-zone. There are clear strain differences in terms of X-zone morphology. Nulliparous females of the inbred mouse DDD strain develop adrenal X-zones containing exclusively vacuolated cells, whereas females of the inbred mouse B6 strain develop X-zones containing only non-vacuolated cells. The X-zone vacuolation is a physiologic process associated with the X-zone degeneration and is tightly regulated by genetic factors. Identification of the genetic factors controlling such strain differences should help analyze the X-zone function. In this study, a quantitative trait locus (QTL) analysis for the extent of X-zone vacuolation was performed for two types of F2 female mice: F2Ay mice (F2 mice with the Ay allele) and F2 non-Ay mice (F2 mice without the Ay allele). These were produced by crossing B6 females and DDD.Cg-Ay males. DDD.Cg-Ay is a congenic mouse strain for the Ay allele at the agouti locus and is used for this study because a close association between the X-zone morphology and the agouti locus genotype has been suggested. The Ay allele is dominant and homozygous lethal; therefore, living Ay mice are invariably heterozygotes. Single QTL scans identified significant QTLs on chromosomes 1, 2, 6, and X for F2 non-Ay mice, and on chromosomes 2, 6, and 12 for F2Ay mice. The QTL on chromosome 2 was considered to be because of the agouti locus, which has been suggested to be associated with X-zone vacuolation. A significant QTL that interacted with the agouti locus was identified on chromosome 8. The extent of X-zone vacuolation in DDD females was controlled by multiple genes with complex interactions. The murine X-zone is considered analogous structure to the human fetal zone. Therefore, the results of this study will aid in understanding function of not only of the X-zone but also of the human fetal zone. Identifying the genes responsible for the QTLs will be

  1. Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome with stroke-like imaging presentation: clinical, biochemical and molecular analysis.

    Science.gov (United States)

    Al-Hassnan, Zuhair N; Rashed, Mohamed S; Al-Dirbashi, Osama Y; Patay, Zoltan; Rahbeeni, Zuhair; Abu-Amero, Khaled K

    2008-01-15

    Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is an autosomal recessive disorder caused by mutations in ORNT1 gene that encodes a mitochondrial ornithine transporter. It has variable clinical presentations with episodic hyperammonemia, liver dysfunction, and chronic neurological manifestations. In this work, we report the findings of HHH syndrome in 3 Saudi siblings. The 4-year-old proband presented with recurrent Reye-like episodes, hypotonia, and multiple stroke-like lesions on brain MRI. Biochemical and molecular analysis confirmed that she had HHH syndrome. She significantly improved on protein restriction and sodium benzoate. Her two older siblings have milder phenotypes with protein intolerance and learning problems. In comparison to their sister, their homocitrulline and orotic acid were only mildly elevated even before treatment. The three patients were homozygous for a novel mutation in ORNT1 with a Gly220Arg change. In view of the CNS lesions, which initially were felt to be suggestive of MELAS, we sequenced the entire mtDNA genome and no potential pathogenic mutations were detected. Analysis of ORNT2 did not provide explanation of the clinical and biochemical variability. This work presents a yet unreported CNS involvement pattern, notably multiple supratentorial stroke-like lesions in association with HHH syndrome. Moreover, it illustrates considerable clinical/biochemical correlation, and describes a novel mutation. We suggest including HHH syndrome in the differential diagnosis of patients found to have stroke-like lesions on brain MRI.

  2. Projected sensitivity to non-resonant Higgs boson pair production in the $b\\bar{b}b\\bar{b}$ final state using proton–proton collisions at HL-LHC with the ATLAS detector

    CERN Document Server

    The ATLAS collaboration

    2016-01-01

    Estimates of the sensitivity to non-resonant Higgs boson pair production using the $HH\\to b\\bar{b}b\\bar{b}$ channel with the full HL-LHC dataset of 3000 fb$^{-1}$ of proton--proton collisions at $\\sqrt{s} = 14\\,$TeV. These estimates are based on the extrapolation of current results obtained with the 2016 dataset, comprising $\\int Ldt = 10.1\\,$fb$^{-1}$ of proton-proton collisions at $\\sqrt{s} = 13\\,$TeV. In the absence of any signal and without (with) systematics, cross-sections 1.5 times (5.2 times) greater than the Standard Model prediction are excluded at the 95% confidence level. The Higgs boson self-coupling, $\\lambda_{HHH}$ can be constrained to $0.2 < \\lambda_{HHH}/\\lambda^{SM}_{HHH} < 7.0$ $(−3.5 < \\lambda_{HHH}/\\lambda^{SM}_{HHH} < 11)$. The sensitivity of the analysis to increasing trigger thresholds has been studied. The jet pT requirement of the projected High-Luminosity LHC trigger increases the cross-section limit by a factor 1.3 (2.2).

  3. Positive iodine-131 6 beta-iodomethyl-19-norcholesterol (NP-59) adrenal images can precede return of adrenocortical function after o,p' DDD treatment

    Energy Technology Data Exchange (ETDEWEB)

    Sparagana, M.; Ackerman, L.

    1988-05-01

    A patient with bilateral adrenal hyperplasia, due to the ectopic adrenocorticotrophic hormone (ACTH) syndrome, received a 3-month course of treatment with 1,1 dichloro-2(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p' DDD), which caused adrenal hypofunction requiring steroid therapy. Eleven months later, Cushing's syndrome recurred. His CT scan showed a left adrenal gland that was enlarged and a normal-sized right adrenal gland. However, the NP-59 image showed increased uptake by both glands. Venous effluent was sampled from each adrenal vein. The plasma cortisol level from the left gland was 1392 ng/ml, and that from the right gland was 667 ng/ml. The latter value was not significantly different from the values obtained at peripheral sites (517-744 ng/ml). In the course of recovery from o,p' DDD damage, the ability of the adrenal gland to take up NP-59 may be restored before the return of its biosynthetic and secretory functions. Serial NP-59 adrenal images can anticipate the recurrence of Cushing's syndrome after adrenolytic therapy, thereby permitting early retreatment.

  4. An approach to 'dynamic--DDD (defined daily dose) monitoring' to reduce adverse clinical outcomes and increase patient safety: information repositories and event triggers in clinical practice.

    Science.gov (United States)

    Eryilmaz, Esat N

    2011-01-01

    The goal of every effort and actions/interventions in almost all healthcare settings throughout the world's health systems -primary care, inpatient, outpatient encounters, diagnostic and therapeutic interventions, peri-operative settings- is and has been to achieve a well defined outcome (a kind of improvement in health status of the patient under consideration, an observable and significant change(s) in selected set(s) of clinical parameters confirmed by laboratory results and pathology findings, improvements in clinical outcomes). Clinical inefficiencies, in this context, should be addressed very systematically and scientifically. This is achieved through a continuously monitoring approach to adverse drug events based on information repositories and evidence-based rule sets. For monitoring drug-related outcomes and clinical outcomes in general, the concept of DDD (Defined Daily Dose) compliance is explained in this article to eliminate and avoid adverse clinical outcomes.

  5. New physics effects in the Higgs trilinear self-coupling through one-loop radiative corrections

    CERN Document Server

    Moyotl, A; Castilla-Valdez, H; Pérez, M A

    2016-01-01

    We compute the one-loop corrections to the triple Higgs self-interaction $hhh$ in the framework of the Standard Model (SM), the Two Higgs Doublet Model type III (THDM-III) and the Littlest Higgs Model with T parity (LHBM+T). Our results are compared with previous results for the SM. In particular, we find that an imaginary part for the $\\lambda_{hhh}$ form factor is induced when one of the Higgs boson legs is off-mass shell with 4-momentum magnitude higher than the Higgs boson mass. This contribution is sensitive to virtual effects of the Higgs self-interaction, that induces a radiative correction to the $hhh$ coupling of order 11%. However, the radiative corrections associated to the new degrees of freedom of the THDM-III and the LHBM+T are rather smaller and comparable to the $W^\\pm$ and $Z^0$ gauge bosons one-loop corrections.

  6. The d'--d--d' vertical triad is less discriminating than the a'--a--a' vertical triad in the antiparallel coiled-coil dimer motif.

    Science.gov (United States)

    Steinkruger, Jay D; Bartlett, Gail J; Hadley, Erik B; Fay, Lindsay; Woolfson, Derek N; Gellman, Samuel H

    2012-02-08

    Elucidating relationships between the amino-acid sequences of proteins and their three-dimensional structures, and uncovering non-covalent interactions that underlie polypeptide folding, are major goals in protein science. One approach toward these goals is to study interactions between selected residues, or among constellations of residues, in small folding motifs. The α-helical coiled coil has served as a platform for such studies because this folding unit is relatively simple in terms of both sequence and structure. Amino acid side chains at the helix-helix interface of a coiled coil participate in so-called "knobs-into-holes" (KIH) packing whereby a side chain (the knob) on one helix inserts into a space (the hole) generated by four side chains on a partner helix. The vast majority of sequence-stability studies on coiled-coil dimers have focused on lateral interactions within these KIH arrangements, for example, between an a position on one helix and an a' position of the partner in a parallel coiled-coil dimer, or between a--d' pairs in an antiparallel dimer. More recently, it has been shown that vertical triads (specifically, a'--a--a' triads) in antiparallel dimers exert a significant impact on pairing preferences. This observation provides impetus for analysis of other complex networks of side-chain interactions at the helix-helix interface. Here, we describe a combination of experimental and bioinformatics studies that show that d'--d--d' triads have much less impact on pairing preference than do a'--a--a' triads in a small, designed antiparallel coiled-coil dimer. However, the influence of the d'--d--d' triad depends on the lateral a'--d interaction. Taken together, these results strengthen the emerging understanding that simple pairwise interactions are not sufficient to describe side-chain interactions and overall stability in antiparallel coiled-coil dimers; higher-order interactions must be considered as well.

  7. Comparison of semipermeable membrane device (SPMD) and large-volume solid-phase extraction techniques to measure water concentrations of 4,4'-DDT, 4,4'-DDE, and 4,4'-DDD in Lake Chelan, Washington.

    Science.gov (United States)

    Ellis, Steven G; Booij, Kees; Kaputa, Mike

    2008-07-01

    Semipermeable membrane devices (SPMDs) spiked with the performance reference compound PCB29 were deployed 6.1 m above the sediments of Lake Chelan, Washington, for a period of 27 d, to estimate the dissolved concentrations of 4,4'-DDT, 4,4'-DDE, and 4,4'-DDD. Water concentrations were estimated using methods proposed in 2002 and newer equations published in 2006 to determine how the application of the newer equations affects historical SPMD data that used the older method. The estimated concentrations of DDD, DDE, and DDD calculated using the older method were 1.5-2.9 times higher than the newer method. SPMD estimates from both methods were also compared to dissolved and particulate DDT concentrations measured directly by processing large volumes of water through a large-volume solid-phase extraction device (Infiltrex 300). SPMD estimates of DDD+DDE+DDT (SigmaDDT) using the older and newer methods were lower than Infiltrex concentrations by factors of 1.1 and 2.3, respectively. All measurements of DDT were below the Washington State water quality standards for the protection of human health (0.59 ng l(-1)) and aquatic life (1.0 ng l(-1)).

  8. Assessment of upper-limb capacity, performance, and developmental disregard in children with cerebral palsy: validity and reliability of the revised Video-Observation Aarts and Aarts module: Determine Developmental Disregard (VOAA-DDD-R)

    NARCIS (Netherlands)

    Houwink, A.; Geerdink, Y.A.; Steenbergen, B.; Geurts, A.C.H.; Aarts, P.B.M.

    2013-01-01

    AIM: To investigate the validity and reliability of the revised Video-Observation Aarts and Aarts module: Determine Developmental Disregard (VOAA-DDD-R). METHOD: Upper-limb capacity and performance were assessed in children with unilateral spastic cerebral palsy (CP) by measuring overall duration of

  9. Assessment of upper-limb capacity, performance, and developmental disregard in children with cerebral palsy: validity and reliability of the revised Video-Observation Aarts and Aarts module: Determine Developmental Disregard (VOAA-DDD-R)

    NARCIS (Netherlands)

    Houwink, A.; Geerdink, Y.A.; Steenbergen, B.; Geurts, A.C.H.; Aarts, P.B.M.

    2013-01-01

    Aim To investigate the validity and reliability of the revised Video-Observation Aarts and Aarts module: Determine Developmental Disregard (VOAA-DDD-R). Method Upper-limb capacity and performance were assessed in children with unilateral spastic cerebral palsy (CP) by measuring overall duration of a

  10. Excretion of radioactivity following the intraperitoneal administration of /sup 14/C-DDT, /sup 14/C-DDD, /sup 14/C-DDE and /sup 14/C-DDMU to the rat and Japanese Quail

    Energy Technology Data Exchange (ETDEWEB)

    Fawcett, S.C. (Univ. of Surrey, Guildford, England); Bunyan, P.J.; Huson, L.W.; King, L.J.; Stanley, P.I.

    1981-09-01

    A study in progress to examine the metabolic fate of DDT in birds and mammals is discussed. The first phase of the study, which is reported in this article, has been to establish the rate of excretion of ratioactivity following the intraperitoneal administrations of /sup 14/C-DDT, /sup 14/C-DDE, /sup 14/C-DDD, and /sup 14/C-DDMU to male rats and male Japanese quail. The mean values from the three animals in each experimental group for the amount of radioactivity excreted daily are given, and it was found that the rats excreted the radioactivity administered as DDT, DDD, and DDE substantially faster than did the quail. DDMU was excreted relatively rapidly and at similar rates. This finding suggests that apparent differences in the rates of excretion of DDT by birds and mammals probably arise from differences in the conversion of DDT to DDD or DDE or in the degradation of these metabolites to DDMU. The Japanese quail differ from the rats in excreting substantial amounts of unchanged DDT, DDE, and DDD, which probably reflects the inability of the Japanese quail to readily metabolise these compounds.

  11. Test of the triple Higgs boson form factor in $\\mu^-\\mu^+\\to HH$

    CERN Document Server

    Gounaris, G J

    2016-01-01

    We study the sensitivity of the process $\\mu^-\\mu^+\\to HH$ to the $q^2$-dependence of the $HHH$ form factor, which can reflect the Higgs boson structure, especially in the case of compositeness. We compute the Born and 1 loop SM contribution to this process. We then show how the $\\mu^-\\mu^+\\to HH$ polarized and unpolarized cross sections are modified by the presence of various types of anomalous contributions to the $HHH$ form factor, in particular Higgs constituents in the case of compositeness.

  12. Higgs boson pair production at the Photon Linear Collider in the two Higgs doublet model

    CERN Document Server

    Asakawa, Eri; Kanemura, Shinya; Okada, Yasuhiro; Tsumura, Koji

    2009-01-01

    We calculate the cross section of the lightest Higgs boson pair production at the Photon Linear Collider in the two Higgs doublet model. We focus on the scenario in which the lightest Higgs boson has the standard model like couplings to gauge bosons. We take into account the one-loop correction to the $hhh$ coupling as well as additional one-loop diagrams due to charged bosons to the $\\gamma\\gamma \\to hh$ helicity amplitudes. We discuss the impact of these corrections on the $hhh$ coupling measurement at the Photon Linear Collider.

  13. A new direct absorption tunable diode laser spectrometer for high precision measurement of water vapor in the upper troposphere and lower stratosphere

    Science.gov (United States)

    Sargent, M. R.; Sayres, D. S.; Smith, J. B.; Witinski, M.; Allen, N. T.; Demusz, J. N.; Rivero, M.; Tuozzolo, C.; Anderson, J. G.

    2013-07-01

    We present a new instrument for the measurement of water vapor in the upper troposphere and lower stratosphere (UT/LS), the Harvard Herriott Hygrometer (HHH). HHH employs a tunable diode near-IR laser to measure water vapor via direct absorption in a Herriott cell. The direct absorption technique provides a direct link between the depth of the observed absorption line and the measured water vapor concentration, which is calculated based on spectroscopic parameters in the HITRAN database. While several other tunable diode laser (TDL) instruments have been used to measure water vapor in the UT/LS, HHH is set apart by its use of an optical cell an order of magnitude smaller than those of other direct absorption TDLs in operation, allowing for a more compact, lightweight instrument. HHH is also unique in its integration into a common duct with the Harvard Lyman-α hygrometer, an independent photo-fragment fluorescence instrument which has been thoroughly validated over 19 years of flight measurements. The instrument was flown for the first time in the Mid-latitude Airborne Cirrus Properties Experiment (MACPEX) on NASA's WB-57 aircraft in spring, 2011, during which it demonstrated in-flight precision of 0.1 ppmv (1 s) with 1-sigma uncertainty of 5% ± 0.7 ppmv. Since the campaign, changes to the instrument have lead to improved accuracy of 5% ± 0.2 ppmv as demonstrated in the laboratory. During MACPEX, HHH successfully measured water vapor at concentrations from 3.5 to 600 ppmv in the upper troposphere and lower stratosphere. HHH and Lyman-α, measuring independently but under the same sampling conditions, agreed on average to within 1% at water vapor mixing ratios above 20 ppmv and to within 0.3 ppmv at lower mixing ratios. HHH also agreed with a number of other in situ water vapor instruments on the WB-57 to within their stated uncertainties, and to within 0.7 ppmv at low water. This agreement constitutes a significant improvement over past in situ comparisons, in

  14. Clinical application of single lead DDD and VDD pacing in elderly%老年人单导管DDD、VDD起搏系统的临床应用

    Institute of Scientific and Technical Information of China (English)

    蔡鑫; 高大胜; 史晓俊; 宋业年; 张宁汝; 冯慧勤

    2002-01-01

    目的观察老年人单导管双腔起搏器(DDD)和心房感知型起搏器(VDD)起搏系统的临床应用. 方法 18例老年人采用锁骨下静脉穿刺法植入单导管DDD和VDD起搏器,并在植入后1周,3~6月分别做动态心电图(Holter)观察,随访时间6月~4年. 结果 18例患者均成功植入单导管DDD和VDD起搏系统.Holter检查显示:VDD和DDD起搏器的工作模式大多为VAT,房室同步起搏率达95%以上. 结论单导管DDD和VDD起搏系统安装简单,无心房电极脱位等优点,尤其适用于老年患者.

  15. p,p'-DDD对人乳腺癌细胞的增殖作用%Study of the Proliferation Effect of DDD on Mammary Cancer Cell MCF-7

    Institute of Scientific and Technical Information of China (English)

    董力; 张明; 汤宁

    2010-01-01

    [目的]观察对,对-二氯二苯基二氯乙烷(p,p'-DDD)对人乳腺癌(MCF-7)细胞增殖的影响.[方法]采用体外培养MCF-7细胞增殖试验检测DDD的类雌激素活性,并用生长曲线对其作用机制进行初步探讨.[结果]DDD染毒剂量在3×10-7mol/L、3×10-6mol/L时,存在刺激MCF-7细胞增殖的类雌激素活性(P<0.05),在3×10-6mol/L剂量时其增殖效应最大.细胞生长曲线方面,DDD组在第3、5、7天各时间段细胞数均明显高于溶剂对照组(P<0.05).[结论]DDD在3×10-7mol/L、3×10-6mol/L具有刺激MCF-7细胞增殖的类雌激素活性.

  16. Design and implementation of light-weighted Spring-DDD plug-in driven by domain message%基于领域消息驱动的轻量级Spring-DDD插件设计与实现

    Institute of Scientific and Technical Information of China (English)

    王薇; 黄强

    2015-01-01

    DDD (domain driven development) is entirely memory⁃based business object modeling (In⁃Memory) method, but the current DDD framework is not stable enough to cover the system business completely and can not be applied to the de⁃velopment of practical project. On the basis of Spring framework,the DDD plug⁃in based on domain message driving and memo⁃ry modeling was realized,in which the implementation of the project is fully compatible with DDD design without affecting the current system architecture. The domain event message and domain object caching model based on JDK and Disruptor concurren⁃cy control framework can effectively reduce the decoupling relationship and improve the whole performance and efficiency of the system.%领域驱动开发(DDD)是完全基于内存的业务对象建模(In⁃Memory)方法,而目前的DDD框架不能完全覆盖系统业务,也不成熟稳定,无法应用于实际项目的开发。在Spring框架的基础上,实现了一个基于领域消息驱动和内存建模的DDD插件,在不影响目前系统架构的基础上,让项目实施完全兼容DDD设计。同时基于JDK和Disruptor并发框架实现的领域事件消息和领域对象缓存模型,有效地降低了系统的解耦关系,并提高了系统的整体性能及效率。

  17. Assessment of right ventricular myocardium motion in patient with DDD pacing using VVI%速度向量成像观察双腔起搏前后右心室运动状态

    Institute of Scientific and Technical Information of China (English)

    周春蕾; 许迪; 陆凤翔; 江立红; 郑真; 施斌斌

    2011-01-01

    Objective To assess right ventricular myocardium motion in patients with dual chamber pacing (DDD) using velocity vector imaging (VVI), and to explore the clinical application value of VVI in evaluating right ventricular motion. Methods 23 patients before and after DDD pacemaker implantation were enrolled in this study. The peak systolic displacement of right ventricular segments was measured with VVI.The difference between pre and post pacemaker implantation was analyzed. Results Right ventricular displacement before and after DDD pacing was significantly decreasing from basal, mid to apical segments ( P <0.01 ). Compared with the values at the baseline, the displacement of interventricular septum, free wall and right ventricle with pacing was decreased (P < 0.01 ). Conclusions Right ventricular displacement with pacing was significantly decreased compared with the values at the baseline. VVI can accurately assess right ventricular systolic displacement in patients with DDD pacing, and objectively reflect right ventricular myocardial motion and function.%目的 探讨速度向量成像(VVI)技术分析双腔(DDD)起搏前后右心室心肌运动位移的变化规律,初步探讨VVI技术在评价右心室运动方面的应用价值.方法 23例DDD起搏患者术前术后均采用VVI技术检测右心室室壁各节段心肌收缩期纵向运动位移,并比较术前术后之差异.结果 术前术后右心室各室壁不同节段心肌收缩峰值位移表现为从基底段到心尖段依次降低,其中基底段与心尖段的差异有统计学意义(P<0.01);与术前相比,术后后间隔、游离壁及右心室整体位移较术前显著降低,差异有统计学意义(P<0.01).结论 DDD起搏后右心室心肌运动位移较术前明显降低;VVI可精确测量DDD起搏前后右心室心肌位移的程度,从而客观反映右心室之运动状态,进而判断右心室之功能.

  18. 瓣膜置换术后窦性心动过缓VVI与DDD起搏的随访观察%The follow-up observation for VVI and DDD pacing in sinus bradycardia after valve replacement

    Institute of Scientific and Technical Information of China (English)

    陈敏; 李莉; 徐志云

    2011-01-01

    Objective To compare the clinical effects of VVI and DDD pacing in sinus bradycardia in patients after valve replacement. Methods All 29 patients with sinus bradycardia after valve replacement were divided into 2 groups by different pacing-mode:DDD group(n = 17) ,VVI group(n = 12). The changes of left ventricular ejection fraction, fractional shortening and the size of atrial ventricular, the occurrence of permanence atrial fibrillation(AF) , the hospitalization for heart failure, the stroke and the death were followed up. Results Mean follow-up was 28 months; All patients had no complications in pacemaker implantation. There was none of stroke and death during the follow-up period. The incidence rate of permanence AF in DDD group was significantly lower than that in VVI group; The hospitalization rate for heart failure in DDD group was significantly lower than that in VVI group . The left atrial volume and diameter in VVI group was significantly increased compared with baseline,but which were not significantly increased in DDD group; The ejection fraction in VVI group was lower than that in DDD group( 0.57 ± 0.08 vs 0.63 ± 0.10, P < 0.05 ). Conclusion Compare to VVI pacing,DDD pacing gets the lower ratio of permanent AF, the lower ratio of the hospitalization for heart failures and improves the cardiac remodelling and function in patients who have sinus bradycardia after valve replacement. [ Chinese Journal of Cardiac Pacing and Electrophyswlogy,2011,25(4) :313 -315]%目的 探讨VVI与DDD起搏对瓣膜置换术后窦性心动过缓患者疗效的差异.方法 瓣膜置换术后窦性心动过缓患者29例,按不同起搏方式分为:DDD组(n=17例),VVI组(n=12例),观察左室射血分数,短轴缩短率,心房心室变化,永久性心房颤动(简称房颤),卒中,心力衰竭(简称心衰)住院,死亡的发生.结果 两组患者均未发生起搏器安置术并发症,在平均随访28个月,未发生卒中、死亡.

  19. Prevalence of E/A wave fusion and A wave truncation in DDD pacemaker patients with complete AV block under nominal AV intervals.

    Directory of Open Access Journals (Sweden)

    Wolfram C Poller

    Full Text Available Optimization of the AV-interval (AVI in DDD pacemakers improves cardiac hemodynamics and reduces pacemaker syndromes. Manual optimization is typically not performed in clinical routine. In the present study we analyze the prevalence of E/A wave fusion and A wave truncation under resting conditions in 160 patients with complete AV block (AVB under the pre-programmed AVI. We manually optimized sub-optimal AVI.We analyzed 160 pacemaker patients with complete AVB, both in sinus rhythm (AV-sense; n = 129 and under atrial pacing (AV-pace; n = 31. Using Doppler analyses of the transmitral inflow we classified the nominal AVI as: a normal, b too long (E/A wave fusion or c too short (A wave truncation. In patients with a sub-optimal AVI, we performed manual optimization according to the recommendations of the American Society of Echocardiography.All AVB patients with atrial pacing exhibited a normal transmitral inflow under the nominal AV-pace intervals (100%. In contrast, 25 AVB patients in sinus rhythm showed E/A wave fusion under the pre-programmed AV-sense intervals (19.4%; 95% confidence interval (CI: 12.6-26.2%. A wave truncations were not observed in any patient. All patients with a complete E/A wave fusion achieved a normal transmitral inflow after AV-sense interval reduction (mean optimized AVI: 79.4 ± 13.6 ms.Given the rate of 19.4% (CI 12.6-26.2% of patients with a too long nominal AV-sense interval, automatic algorithms may prove useful in improving cardiac hemodynamics, especially in the subgroup of atrially triggered pacemaker patients with AV node diseases.

  20. Atrial and ventricular stimulation threshold development: a comparative study in patients with a DDD pacemaker and two identical carbon-tip leads.

    Science.gov (United States)

    Brandt, J; Attewell, R; Fåhraeus, T; Schüller, H

    1990-07-01

    The atrial and ventricular pacing threshold development during the first postoperative year was studied in a group of patients receiving DDD pacemakers. Identical carbon-tip endocardial leads were implanted in atrium and ventricle. Atrial and ventricular voltage stimulation thresholds were measured at implantation, and noninvasively at 1 and 12 months thereafter. The atrial amplifier sensitivity required for adequate P wave sensing during follow-up was also determined. The possible influence of a number of factors upon atrial and ventricular threshold evolution was statistically assessed. The threshold data were complete in 57 patients (mean age +/- SD, 65.2 +/- 12.4 years). Thirteen patients had a diagnosis of sinus node disease, whereas 44 had not. Patient age and diagnosis did not significantly influence atrial or ventricular stimulation threshold development. Atrial sensing thresholds were not related to atrial stimulation thresholds during follow-up. Atrial pacing thresholds were higher than ventricular thresholds at pacemaker implantation (P less than 0.00005), but the postoperative threshold rise and thresholds at 1 and 12 months postoperatively did not differ significantly between the atrium and ventricle. The ratio of chronic to acute stimulation thresholds was higher on the ventricular than on the atrial level (0.001 greater than P greater than 0.0005). The chronic atrial threshold showed a logarithmic relation to the threshold at implantation (P = 0.0006); postoperative threshold rise was not a significant determinant of the chronic atrial threshold (P = NS). On the ventricular level, the reverse was seen: The chronic threshold was related to the postoperative threshold rise (P = 0.0015, logarithmic relation), but not to the implantation threshold (P = NS).(ABSTRACT TRUNCATED AT 250 WORDS)

  1. Prevalence of E/A wave fusion and A wave truncation in DDD pacemaker patients with complete AV block under nominal AV intervals.

    Science.gov (United States)

    Poller, Wolfram C; Dreger, Henryk; Schwerg, Marius; Melzer, Christoph

    2015-01-01

    Optimization of the AV-interval (AVI) in DDD pacemakers improves cardiac hemodynamics and reduces pacemaker syndromes. Manual optimization is typically not performed in clinical routine. In the present study we analyze the prevalence of E/A wave fusion and A wave truncation under resting conditions in 160 patients with complete AV block (AVB) under the pre-programmed AVI. We manually optimized sub-optimal AVI. We analyzed 160 pacemaker patients with complete AVB, both in sinus rhythm (AV-sense; n = 129) and under atrial pacing (AV-pace; n = 31). Using Doppler analyses of the transmitral inflow we classified the nominal AVI as: a) normal, b) too long (E/A wave fusion) or c) too short (A wave truncation). In patients with a sub-optimal AVI, we performed manual optimization according to the recommendations of the American Society of Echocardiography. All AVB patients with atrial pacing exhibited a normal transmitral inflow under the nominal AV-pace intervals (100%). In contrast, 25 AVB patients in sinus rhythm showed E/A wave fusion under the pre-programmed AV-sense intervals (19.4%; 95% confidence interval (CI): 12.6-26.2%). A wave truncations were not observed in any patient. All patients with a complete E/A wave fusion achieved a normal transmitral inflow after AV-sense interval reduction (mean optimized AVI: 79.4 ± 13.6 ms). Given the rate of 19.4% (CI 12.6-26.2%) of patients with a too long nominal AV-sense interval, automatic algorithms may prove useful in improving cardiac hemodynamics, especially in the subgroup of atrially triggered pacemaker patients with AV node diseases.

  2. Data of evolutionary structure change: 1EUZB-1HRDA [Confc[Archive

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  7. Data of evolutionary structure change: 1CTWA-205LA [Confc[Archive

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  8. Data of evolutionary structure change: 1M39A-2CTNA [Confc[Archive

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  10. Data of evolutionary structure change: 1EDEA-2PSEA [Confc[Archive

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  11. Data of evolutionary structure change: 1AIAB-1YAAA [Confc[Archive

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  12. Data of evolutionary structure change: 1B99C-2AZ1D [Confc[Archive

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  13. Data of evolutionary structure change: 1ACMA-3GD5D [Confc[Archive

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  14. Three-body recombination in spin-polarized atomic hydrogen

    NARCIS (Netherlands)

    Goey, L.P.H. de; Berg, T.H.M. van de; Mulders, N.; Stoof, H.T.C.; Verhaar, B.J.; Glöckle, W.

    1986-01-01

    In view of the failure of the Kagan dipole mechanism to explain the magnetic field dependence of the H+H+H recombination rate in spin-polarized atomic hydrogen, we consider an additional process, the so-called dipole-exchange mechanism. Two simple approaches to estimate its consequences turn out to

  15. Data of evolutionary structure change: 1CEVC-2ZAVB [Confc[Archive

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  16. Data of evolutionary structure change: 1CEVC-5RLAC [Confc[Archive

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    Full Text Available 1CEVC-5RLAC 1CEV 5RLA C C MKPISIIGVPMDLGQTRRGVDMGPSAMRYAGVIERLERL...dbChain>C 1CEVC ALTQI---GGYSP C 1CEVC YLKER-TDGVH HHH ...pdbChain> 1CEVC LDERN----KTASV ...>1CEV C 1CEVC

  17. 77 FR 59554 - Approval and Promulgation of Implementation Plans; Georgia; Control Techniques Guidelines and...

    Science.gov (United States)

    2012-09-28

    ... Manufacturing. * * * * * * * 391-3-1-.02(2)(hhh) Wood Furniture 4/12/2009 9/28/2012 [Insert citation of..., proposed rulemaking. Specifically, these rules are Rules 391-1-.02(2)(y) Metal Furniture, (ff) Solvent...)(y) VOC Emissions from 3/7/2012 9/28/2012 [Insert citation of Metal Furniture publication]....

  18. Data of evolutionary structure change: 1ATGA-2H5YA [Confc[Archive

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  19. Density dependence of clutch size : habitat heterogeneity or individual adjustment?

    NARCIS (Netherlands)

    Both, Christiaan

    1998-01-01

    1.   Two hypotheses have been proposed to explain density-dependent patterns in reproduction. The habitat heterogeneity hypothesis (HHH) explains density-dependent reproduction at the population level from poorer quality territories in hetero geneous environments only being occupied at high

  20. Adult-onset presentation of a hyperornithinemia-hyperammonemia-homocitrullinuria patient without prior history of neurological complications.

    Science.gov (United States)

    Tezcan, Kamer; Louie, Kristal T; Qu, Yong; Velasquez, Jorge; Zaldivar, Frank; Rioseco-Camacho, Natalia; Camacho, José Angel

    2012-01-01

    The Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) syndrome is a disorder of the urea cycle and ornithine degradation pathway caused by mutations in the mitochondrial ornithine transporter, ORNT1 (SLC25A15). In general, the majority of patients with HHH syndrome come to medical attention during infancy or early school years with symptoms such as learning disabilities, changes in cognitive development, spasticity, or liver dysfunction. In this report, we describe a 35-year-old male of Indian descent who was diagnosed with HHH syndrome after he presented to the emergency room with gastroenteritis, disorientation, and slurred speech. Molecular analysis revealed that this patient was heterozygous for two ORNT1 mutations, p.[Gly220Arg(+)Arg275X] (c.[658G>A(+)823C>T]) that had been previously reported in homozygous probands who presented during the first year of life. Cellular studies revealed that the ORNT1 p.Gly220Arg mutation was nonfunctional but targeted to the mitochondria. Given that this patient was a successful college graduate on a vegetarian diet without a prior history of learning or neurological impairment, additional factors such as gene redundancy, environmental, and epigenetic factors may have contributed to the delay in onset of presentation and lack of any previous symptoms. To the best of our knowledge, this is the first reported case of an adult-onset HHH syndrome presentation without a prior history of neurological or cognitive deficiency.

  1. Data of evolutionary structure change: 1DFID-2QIOB [Confc[Archive

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  3. Accelerator Physics Code Web Repository

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, F.; Basset, R.; Bellodi, G.; Benedetto, E.; Dorda, U.; Giovannozzi, M.; Papaphilippou, Y.; Pieloni, T.; Ruggiero, F.; Rumolo, G.; Schmidt, F.; Todesco, E.; Zotter, B.W.; /CERN; Payet, J.; /Saclay; Bartolini, R.; /RAL, Diamond; Farvacque, L.; /ESRF, Grenoble; Sen, T.; /Fermilab; Chin, Y.H.; Ohmi, K.; Oide, K.; /KEK, Tsukuba; Furman, M.; /LBL, Berkeley /Oak Ridge /Pohang Accelerator Lab. /SLAC /TRIUMF /Tech-X, Boulder /UC, San Diego /Darmstadt, GSI /Rutherford /Brookhaven

    2006-10-24

    In the framework of the CARE HHH European Network, we have developed a web-based dynamic accelerator-physics code repository. We describe the design, structure and contents of this repository, illustrate its usage, and discuss our future plans, with emphasis on code benchmarking.

  4. ACCELERATION PHYSICS CODE WEB REPOSITORY.

    Energy Technology Data Exchange (ETDEWEB)

    WEI, J.

    2006-06-26

    In the framework of the CARE HHH European Network, we have developed a web-based dynamic accelerator-physics code repository. We describe the design, structure and contents of this repository, illustrate its usage, and discuss our future plans, with emphasis on code benchmarking.

  5. Data of evolutionary structure change: 1JJIA-3H1BA [Confc[Archive

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  7. Disease: H01268 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H01268 Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome; HHH syndrome Hyperornithinemia-hype... from modeling human mitochondrial ornithine transporter-1. PLoS One 7:e31048 (2012) PMID:22649802 Camacho J, Rioseco-Camacho N Hype...rornithinemia-Hyperammonemia-Homocitrullinuria Syndrome (1993) ...

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  11. Data of evolutionary structure change: 1AHBA-3CTKA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available K A 3CTKA AVFLDKVPTVAT ...1AHBA-3CTKA 1AHB 3CTK A A --DVSFRLSGADPRSYGMFIKDLRNALPFREKVYNIPLL...FKYIETEVVDRGLYGSFKPNFKVLNLENNWGDISDAIHKSSPQCTTINPALQLISPSNDPWVVNKVS--QISPDMGILKFKS-- -- EEE HHH...in>1AHBA SYFFN--EPAAE ure>EEEE -- HHALA CA 311 ALA CA 377 GLU CA 294 3CT

  12. Resonance Production of Three Neutral Supersymmetric Higgs Bosons at LHC

    CERN Document Server

    Cynolter, G; Pócsik, G

    2000-01-01

    Multiple production of Higgs particles is essential to study Higgsself-couplings at future high-energy colliders. In this paper we calculated theresonance contributions to the production of three lightest neutralsupersymmetric Higgs bosons in gluon fusion at LHC. The cross sections due totrilinear Higgs couplings is sizeable but the measurement of the quarticcoupling hhhH(h) seems to be impossible.

  13. Data of evolutionary structure change: 1SPXA-3GRPA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1SPXA-3GRPA 1SPX 3GRP A A --TRFAEKVAIITGSSNGIGRATAVLFAREGAKVTITGR...CA 127 SER CA 177 TYR CA 211 ASP CA 201 3GRP... A 3GRPA NAGITVRM...ine>VAL CA 575 ASN CA 567 3GRP A 3GRPA MMRRRYGRIIN HHH

  14. Data of evolutionary structure change: 1OZHA-1UPCD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZHA-1UPCD 1OZH 1UPC A D VRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLL...>LYS CA 249 VAL CA 284 1UPC D... 1UPCD LLGSSEGIDTPNPP HHH ... ILE CA 324 ASP CA 254 1UPC D 1UPCD GVVADGWQKAAD

  15. Data of evolutionary structure change: 1OZHC-1UPCB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZHC-1UPCB 1OZH 1UPC C B VRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLL...ine>LYS CA 250 VAL CA 278 1UPC B 1UPCB LLGSSEGIDTPN HHH...ine>ALA CA 186 MET CA 181 1UPC B 1UPCB TPNPPANTPAKP

  16. Data of evolutionary structure change: 1DTHB-3B8ZB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available entryIDChain>1DTHB NGFYR----SLNIH >HHH ---- E...dbID>3B8Z B 3B8ZB NRLYSHASIENHIR ...>HHHH GGG EEEucture> ATOM 1942 CA ASN B 299 2...n> 1DTHB EIWSN-EDQIN ...>EE - > ATOM 2052 CA GLU B 57 6.491 46.203 49.509 1.0

  17. Higgs self-coupling in the MSSM and NMSSM after the LHC Run 1

    CERN Document Server

    Wu, Lei; Yuan, Chien-Peng; Zhang, Mengchao

    2015-01-01

    We examine the trilinear self-coupling of the SM-like 125 GeV Higgs boson ($h$) in the minimal supersymmetric model (MSSM) and the next-to-minimal supersymmetric model (NMSSM) after the LHC Run-1. Considering the current experimental constraints, such as the Higgs data, the flavor constraints, the electroweak precision observables as well as the dark matter detections, we scan over the parameter space and obtain the following observations: (1) In the MSSM, the self-coupling is suppressed relative to the SM value. But, due to the tightly constrained parameter space, such a suppression is rather weak and the ratio $\\lambda^{\\rm MSSM}_{hhh}/\\lambda^{\\rm SM}_{hhh}$ is above 0.97; (2) In the NMSSM with $\\lambda0.7$ (also called $\\lambda$-SUSY), the self-coupling can be greatly suppressed or enhanced relative to the SM value (with the ratio $\\lambda^{\\rm NMSSM}_{hhh}/\\lambda^{\\rm SM}_{hhh}$ varying from -1.1 to 1.9), accompanied by a sizable change in $h\\tau^+\\tau^-$ coupling.

  18. Remarkable improvement of methylglyoxal synthase thermostability by His-His interaction.

    Science.gov (United States)

    Mohammadi, Malihe; Kashi, Mona Atabakhshi; Zareian, Shekufeh; Mirshahi, Manoochehr; Khajeh, Khosro

    2014-01-01

    Lately it has been proposed that interaction between two positively charged side chains can stabilize the folded state of proteins. To further explore this point, we studied the effect of histidine-histidine interactions on thermostability of methylglyoxal synthase from Thermus sp. GH5 (TMGS). The crystal structure of TMGS revealed that His23, Arg22, and Phe19 are in close distance and form a surface loop. Here, two modified enzymes were produced by site-directed mutagenesis (SDM); one of them, one histidine (TMGS-HH(O)), and another two histidines (TMGS-HHH(O)) were inserted between Arg22 and His23 (H(O)). In comparison with the wild type, TMGS-HH(O) thermostability increased remarkably, whereas TMGS-HHH(O) was very unstable. To explore the role of His23 in the observed phenomenon, the original His23 in TMGS-HHH(O) was replaced with Ala (TMGS-HHA). Our data showed that the half-life of TMGS-HHA decreased in relation to the wild type. However, its half-life increased in comparison with TMGS-HHH(O). These results demonstrated that histidine-histidine interactions at position 23 in TMGS-HH(O) probably have the main role in TMGS thermostability.

  19. Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding.

    Science.gov (United States)

    Rajan, Rakhi; Taneja, Bhupesh; Mondragón, Alfonso

    2010-07-14

    Topoisomerase V is an archaeal type I topoisomerase that is unique among topoisomerases due to presence of both topoisomerase and DNA repair activities in the same protein. It is organized as an N-terminal topoisomerase domain followed by 24 tandem helix-hairpin-helix (HhH) motifs. Structural studies have shown that the active site is buried by the (HhH) motifs. Here we show that the N-terminal domain can relax DNA in the absence of any HhH motifs and that the HhH motifs are required for stable protein-DNA complex formation. Crystal structures of various topoisomerase V fragments show changes in the relative orientation of the domains mediated by a long bent linker helix, and these movements are essential for the DNA to enter the active site. Phosphate ions bound to the protein near the active site helped model DNA in the topoisomerase domain and show how topoisomerase V may interact with DNA.

  20. Data of evolutionary structure change: 1GB7A-2G4NF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1GB7A-2G4NF 1GB7 2G4N A F KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYN...HHH - GGGG -- EVID>EVID> 0 2G4N F 2G4NF IVQNN--...n> 0.7096549868583679 1.3399250507354736 EVID> 1 2G4N F 2G4NF

  1. Data of evolutionary structure change: 1EQEA-2G4NF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1EQEA-2G4NF 1EQE 2G4N A F KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYN...HHH -GGGG -- EVID>EVID> 0 2G4N F 2G4NF VQNND--S...rotation> 1.4860199689865112 3.0474579334259033 EVID> 1 2G4N F 2G4NF

  2. QTL mapping of genes controlling plasma insulin and leptin concentrations: metabolic effect of obesity QTLs identified in an F2 intercross between C57BL/6J and DDD.Cg-A(y) inbred mice.

    Science.gov (United States)

    Suto, Jun-ichi

    2013-07-31

    DDD.Cg-A(y) female mice developed massive obesity as compared with B6.Cg-A(y) female mice. We previously identified quantitative trait loci (QTLs) for obesity on chromosomes 1, 6, 9 and 17 in F2 female mice, including F2A(y) (F2 mice with the A(y) allele) and F2 non- A(y) mice (F2 mice without the A(y) allele), produced by crossing C57BL/6J and DDD.Cg-A(y) strains. We here addressed the question whether the obesity QTLs share genetic bases with putative QTLs for plasma glucose, insulin and leptin concentrations. We performed QTL analyses for the first principal component (PC1) extracted from these metabolic measurements to identify the genes that contributed to the comprehensive evaluation of metabolic traits. By single QTL scans, we identified two significant QTLs for insulin concentration on chromosomes 6 and 12, three for leptin concentration on chromosomes 1, 6 and 17, and five for PC1 on chromosomes 1, 6, 12 (two loci) and 17. Although insulin and leptin concentrations and PC1 were not normally distributed in combined F2 mice, results of single QTL scans by parametric and non-parametric methods were very similar. Therefore, QTL scan by the parametric method was performed with the agouti locus genotype as a covariate. A significant QTL × covariate interaction was found for PC1 on chromosome 9. All obesity QTLs had significant metabolic effects. Thus, obesity- and diabetes-related traits in DDD.Cg-A(y) mice were largely controlled by QTLs on chromosomes 1, 6, 9, 12 and 17.

  3. Cytogenetic status of human lymphocytes after exposure to low concentrations of p,p'-DDT, and its metabolites (p,p'-DDE, and p,p'-DDD) in vitro.

    Science.gov (United States)

    Gerić, Marko; Ceraj-Cerić, Nikolina; Gajski, Goran; Vasilić, Želimira; Capuder, Željka; Garaj-Vrhovac, Vera

    2012-06-01

    Despite that the use of DDT has been restricted for more than 40 years to malaria affected areas, low doses of this pesticide and its metabolites DDE and DDD can be found in the environment around the world. Although it has been shown that these pollutants induce cell and DNA damage, the mechanisms of their cytogenotoxic activity remains largely unknown. This study looks into their possible genotoxic effects, at doses that can be found in body fluids, on human lymphocytes using the cytokinesis-block micronucleus assay and the comet assay. After exposure for 1, 6, and 24 h compounds p,p'-DDT (0.1 μg mL(-1)), p,p'-DDE (4.1 μg mL(-1)), and p,p'-DDD (3.9 μg mL(-1)) showed increase in DNA damage. The most significant results were observed at exposure period of 24 h where number of micronucleated cells increased from control 2.5±0.71 to 23.5±3.54, 13.5±0.71, and 16.5±6.36 for DDT, DDE, and DDD, respectively. Similar effect was observed using comet test where the percentage of DNA in comets tail increased from control 1.81±0.16 to 17.24±0.55, 11.21±0.56 and 9.28±0.50 for each compound, respectively. At the same time Fpg-comet assay failed to report induction of oxidative DNA damage of these pollutants. Additionally, the type of cell death was determined using diffusion assay and necrosis dominated. Our findings suggest that even at low concentrations, these pesticides could induce cytogenetic damage to human peripheral blood lymphocytes and in that manner have the impact on human health as well. Copyright © 2012 Elsevier Ltd. All rights reserved.

  4. A redução do gradiente na via de saída do ventrículo esquerdo pelo marcapasso DDD em pacientes com miocardiopatia hipertrófica obstrutiva

    Directory of Open Access Journals (Sweden)

    FAES Farid César

    2002-01-01

    Full Text Available OBJETIVO: A estimulação seqüencial atrioventricular (modo DDD tem sido aceita como uma terapêutica eficaz para reduzir o gradiente na via de saída do ventrículo esquerdo (GVSVE em pacientes com miocardiopatia hipertrófica obstrutiva (MHO. O objetivo deste trabalho é avaliar o efeito do marcapasso DDD para redução do GVSVE em pacientes com MHO de má resposta ao tratamento farmacológico e com obstrução na via de saída ventricular esquerda com gradiente crescente ou superior a 50 mmHg. MÉTODO: Um marcapasso de dupla câmara, composto de gerador de pulsos DDD e dos eletrodos atrial e ventricular, foi implantado mediante técnica transvenosa em 42 pacientes no período de fevereiro de 1995 a março de 2001. Foi observada uma redução na sintomatologia e uma melhora na classe funcional na maioria dos pacientes. RESULTADOS: Quanto à classe funcional, na última avaliação, 31 pacientes estavam em classe funcional I, e 10 pacientes na classe funcional II, contrastando com o pré-operatório, quando 30 pacientes estavam na classe funcional III ou IV, e apenas 12 estavam na classe II (p<0,001. A medicação foi ajustada, sendo reduzida ou suspensa em 15 pacientes, substituída em 3 pacientes e aumentada (quanto ao número de fármacos ou sua dose em 14 pacientes. O GVSVE reduziu significativamente de 96,50±30,55 mmHg para 41,80±22,84 mmHg após ajuste do aparelho (p<0,001. CONCLUSÃO: Após o implante do marcapasso DDD existe uma melhora clínica e ecocardiográfica em pacientes com MHO de má resposta ao tratamento clínico. Os resultados obtidos permitem a continuidade do uso da terapêutica em casos selecionados.

  5. Two multidimensional chromatographic methods for enantiomeric analysis of o,p'-DDT and o,p'-DDD in contaminated soil and air in a malaria area of South Africa.

    Science.gov (United States)

    Naudé, Yvette; Rohwer, Egmont R

    2012-06-12

    In rural parts of South Africa the organochlorine insecticide DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) is still used for malaria vector control where traditional dwellings are sprayed on the inside with small quantities of technical DDT. Since o,p'-DDT may show enantioselective oestrogenicity and biodegradability, it is important to analyse enantiomers of o,p'-DDT and its chiral degradation product, o,p'-DDD, for both health and environmental-forensic considerations. Generally, chiral analysis is performed using heart-cut multidimensional gas chromatography (MDGC) and, more recently, comprehensive two-dimensional gas chromatography (GC×GC). We developed an off-line gas chromatographic fraction collection (heart-cut) procedure for the selective capturing of the appropriate isomers from a first apolar column, followed by reinjection and separation on a second chiral column. Only the o,p'-isomers of DDT and DDD fractions from the first dimension complex chromatogram (achiral apolar GC column separation) were selectively collected onto a polydimethylsiloxane (PDMS) multichannel open tubular silicone rubber trap by simply placing the latter device on the flame tip of an inactivated flame ionisation detector (FID). The multichannel trap containing the o,p'-heart-cuts was then thermally desorbed into a GC with time-of-flight mass spectrometry detection (GC-TOFMS) for second dimension enantioselective separation on a chiral column (β-cyclodextrin-based). By selectively capturing only the o,p'-isomers from the complex sample chromatogram, (1)D separation of ultra-trace level enantiomers could be achieved on the second chiral column without matrix interference. Here, we present solventless concentration techniques for extraction of DDT from contaminated soil and air, and report enantiomeric fraction (EF) values of o,p'-DDT and o,p'-DDD obtained by a new multidimensional approach for heart-cut gas chromatographic fraction collection for off-line second dimension

  6. A 2:1 AV rhythm: an adverse effect of a long AV delay during DDI pacing and its prevention by the ventricular intrinsic preference algorithm in DDD mode.

    Science.gov (United States)

    Minamiguchi, Hitoshi; Oginosawa, Yasushi; Kohno, Ritsuko; Tamura, Masahito; Takeuchi, Masaaki; Otsuji, Yutaka; Abe, Haruhiko

    2012-07-01

    A 91-year-old woman received a dual-chamber pacemaker for sick sinus syndrome and intermittently abnormal atrioventricular (AV) conduction. The pacemaker was set in DDI mode with a 350-ms AV delay to preserve intrinsic ventricular activity. She complained of palpitation during AV sequential pacing. The electrocardiogram showed a 2:1 AV rhythm from 1:1 ventriculoatrial (VA) conduction during ventricular pacing in DDI mode with a long AV interval. After reprogramming of the pacemaker in DDD mode with a 250-ms AV interval and additional 100-ms prolongation of the AV interval by the ventricular intrinsic preference function, VA conduction disappeared and the patient's symptom were alleviated without increasing unnecessary right ventricular pacing.

  7. DESIGNING SOA AND DDD-BASED INFORMATION PLATFORM ARCHITECTURE FOR RAILWAY AND WATERWAY COMBINATION TRANSPORTATION%基于SOA和DDD的铁水联运信息平台构架设计

    Institute of Scientific and Technical Information of China (English)

    黄强; 王薇; 倪少权

    2013-01-01

    Railway and waterway combination transportation is the direct outcome of modern information technology.By information integration,it can realise the intellectualisation and real-time performance in various sectors of production and circulation areas so as to improve the time benefit and space benefit.Since the railway and waterway combination transportation for containers starts very late with weak foundation and slow development level,and the information systems of the execution entities their own develop unevenly and do not effectively dock so as to have formed the information silo,these directly impact the integrated railway and waterway transportation and services.Advanced information integration and platform development mode is crucial to the development of railway and waterway combination transportation information system.In this paper we put forward a construction scheme for railway and waterway combination transportation information platform,it is based on SOA (service-oriented architecture) and DDD (domain driven development) framework.Compared with traditional electronic data interchange (EDI),the ESB (enterprise service bus) architecture of SOA is more flexible and efficient in achieving cross-system flow integration; the DDD architecture can effectively build a business system,and the low-coupling structure can also responds quickly to the test and update,so it has greater practical significance.%铁水联运是现代信息技术的直接产物,通过信息整合,在生产和流通领域的各个行业实现智能化、及时化,从而提高经济运行的时间和空间效益.由于我国集装箱铁水联运起步晚,基础薄弱,发展水平低,各实施主体自身的信息系统发展不均衡,未能实现有效对接而形成信息孤岛,对铁水一体化运输和服务带来直接影响.先进的信息整合和平台开发模式对铁水联运信息系统的发展至关重要.提出基于SOA(面向服务构架)和DDD(领域驱动开发)构架

  8. Echocardiography in evaluating right ventricular function of patients with sick sinus syndrome and atrioventricular delay with perianal abscesson under AAI and DDD pacing modes%病态窦房结综合征伴房室传导延迟AAI与DDD起搏模式右心功能的超声评价

    Institute of Scientific and Technical Information of China (English)

    陈晓栋; 许迪; 丁文波; 沈建平; 娄彬; 于圣永

    2012-01-01

    Objective To explore the right ventricular function of patients with sick sinus syndrome and atrioventricular delay under AAI and DDD pacing modes. Methods Thirty - five sick sinus syndrome combined with I degree atrioventricular block implantation of DDD patients with dual chamber pacemaker were included in the study. The program- controlled instrument was used to change the pacemaker to DDD mode first,and then to AAI mode. Echocardiography was employed to detect parameter changes of patients with two kinds of pacing mode. Results RVPEP RVPEP/RVET and Sm,Tei index of DDD pacing mode were significantly higher than those of AAI pacing mode (P<0. 05). The E/Em of DDD pacing mode was less than that of AAI pacing mode (P<0.05). Conclusion The right cardiac systolic and diastolic function of the patients with AV is better under the AAI mode pacing mode than under the DDD mode pacing mode.%目的 探讨AAI与DDD起搏模式下病态窦房结综合征伴房室传导阻滞患者的右心功能.方法 35例病态窦房结综合征伴Ⅰ度房室传导阻滞植入DDD双腔起搏器患者,先用程控仪将起搏器程控为DDD模式,最后程控为AAI模式.超声心动图检测患者2种起搏模式下的各参数变化情况.结果 DDD起搏模式下的RVPEP、RVPEP/RVET、Sm、Tei指数明显高于AAI起搏模式(P<0 05),E/Em低于AAI起搏模式(P<0.05).结论 AAI起搏模式右心的收缩和舒张功能均优于AV间期优化的DDD起搏模式.

  9. Generation and characterization of a human neutralizing bivalent antibody Fab094-DDD against rabies virus%人源特异性抗狂犬病毒二价Fab094-DDD抗体的制备及鉴定

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    目的:利用蛋白激酶A(protein kinase A,PKA)调节亚基(R亚基)的二聚体化功能结构域(DDD)的二聚化功能,制备具有中和活性的人源特异性抗狂犬病毒二价抗体.方法:优化合成linker-C-DDD序列,设计引物扩增抗狂犬病毒抗体Fab094的Fd段和轻链可变区序列(Vκ),通过overlap PCR将Fab094的Fd段和linker-C-DDD基因重组为Fd-DDD,将其和Vκ分别克隆到真核表达载体中,共转染293Free style细胞,表达纯化该抗体.应用SDS-PAGE 、Western blot、ELISA、免疫共沉淀、亲和力测定及免疫荧光试验检测该抗体的免疫学特性,用荧光抗体病毒中和试验检测其中和活性.结果:成功构建了全人源抗狂犬病毒二价抗体Fab094-DDD的真核表达载体,获得的二价Fab094-DDD抗体与抗原保持着较好的亲和力,能特异性结合狂犬病毒,中和效价为213.2 U/mg.结论:成功制备了抗狂犬病毒二价Fab094-DDD抗体,具有较高的中和活性,为进一步研发狂犬病治疗性抗体药物奠定了基础,对于其他疾病双表位人源特异性抗体的制备也具有借鉴作用.

  10. Measurement of the Branching Fractions of Exclusive anti-B -> D/D*/D(*) pi l- anti-nu_l Decays in Events Tagged by a Fully Reconstructed B Meson

    CERN Document Server

    Aubert, B; Boutigny, D; Karyotakis, Yu; Lees, J P; Poireau, V; Prudent, X; Tisserand, V; Zghiche, A; Garra Tico, J; Graugès-Pous, E; Lopez, Spain L; Palano, A; Pappagallo, M; Eigen, Italy`G; Stugu, B; Sun, L; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lopes-Pegna, D; Lynch, G; Mir, L M; Orimoto, T J; Osipenkov, I L; Ronan, M T; Tackmann, K; Tanabé, T; Wenzel, W A; Del Amo-Sánchez, P; Hawkes, C M; Watson, A T; Koch, H; Schröder, T; Walker, D; Asgeirsson, D J; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Mattison, T S; McKenna, J A; Khan, A; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Martin, E C; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Liu, F; Long, O; Shen, B C; Vitug, G M; Zhang, L; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, USAT W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Schalk, T; Schumm, B A; Seiden, A; Wilson, M G; Winstrom, L O; Chen, E; Cheng, C H; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Andreassen, R; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Gabareen, A M; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Klose, V; Kobel, M J; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Lombardo, V; Thiebaux, C; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Watson, J E; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Franchini, P; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Santoro, V; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, Italy A; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Dauncey, P D; Flack, R L; Nash, J A; Panduro-Vazquez, W; Tibbetts, M; Behera, P K; Chai, X; Charles, M J; Mallik, U; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gao, Y Y; Gritsan, A V; Guo, Z J; Lae, C K; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Bequilleux, J; D'Orazio, A; Davier, M; Grosdidier, G; Höcker, A; Lepeltier, V; Le Diberder, F; Lutz, e A M; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wang, L; Wang, W F; Wormser, G; Lange, D J; Wright, D M; Bingham, I; Burke, J P; Chavez, C A; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; George, K A; Di Lodovico, F; Sacco, R; Sigamani, M; Cowan, G; Flächer, H U; Hopkins, D A; Paramesvaran, S; Salvatore, F; Wren, A C; Brown, D N; Davis, C L; Allison, USAJ; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; West, T J; Yi, J I; Anderson, J; Chen, C; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Salvati, E; Saremi, S; Cowan, R; Dujmic, D; Fisher, P H; Koeneke, K; Sciolla, G; Spitznagel, M; Taylor, F; Yamamoto, R K; Zhao, M; Zheng, Y; Mclachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, Italy J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaudoe, F B; Nicholson, H; De Nardo, Gallieno; Fabozzi, F; Lista, L; Monorchio, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; Knoepfel, K J; LoSecco, J M; Benelli, G; Corwin, L A; Honscheid, K; Kagan, H; Kass, R; Morris, J P; Rahimi, A M; Regensburger, J J; Sekula, S J; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gagliardi, N; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Ben-Haim, E; Briand, H; Calderini, G; Chauveau, J; David, P; Del Buono, L; De La Vaissière, C; Hamon, O; Leruste, P; Malcles, J; Ocariz, J; Pérez, A; Prendkie, J; Gladney, L; Biasini, M; Covarelli, R; Manoni, E; CAngelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Cenci, R; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Biesiada, J; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Baracchini, E; Bellini, F; Cavoto, G; Del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, P; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Renga, F; Voena, C; Ebert, M; Hartmann, T; Schröder, H; Waldi, R; Adye, T; Castelli, G; Franek, B; Olaiya, E; Röthel, W; Wilson, F F; Emery, S; Escalier, M; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, W; Vasseur, G; Yeche, Ch; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; White, R M; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle,; Claus, P; Coleman, J P; Convery, M R; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Hast, C; Innes, W R; Kaminski, J; Kelsey, M H; Kim, H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; Nelson, S; O'Grady, C P; Ofte, I; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; chwiening, J; Snyder, A; Su, D; Sun, S; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Wagner, A P; Weaver, M; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Ziegler, V; Burchat, P R; Edwards, A J; Majewski, S A; Miyashita, T S; Petersen, B A; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Krishnamurthy, M; Spanier, S M; Wogsland, B J; Eckmann, R; Ritchie, J L; Ruland, A M; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini,; Lopez-March, N; Martínez-Vidal, F; Milanes, D A; Oyanguren, A; Albert, J; Banerjee, Sw; Bhuyan, B; Hamano, K; Kowalewski, R; Nugent, I M; Roney, J M; Sobie, R J; Harrison, P F; Ilic, J; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Dasu, S; Flood, K T; Hollar, J J; Kutter, P E; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Neal, H

    2007-01-01

    We present a measurement of the branching fractions for anti-B -> D/D*/D(*) pi l^- anti-nu_l decays based on 341.1 fb-1 of data collected at the Upsilon(4S) resonance with the BaBar detector at the pep-II e^+e^- storage rings. Events are tagged by fully reconstructing one of the B mesons in a hadronic decay mode. We obtain BF (B^- -> D^0 l^- anti-nu_l) = (2.33 +/- 0.09(stat.) +/- 0.09(syst.))%, BF (B^- -> D^*0 l^- anti-nu_l) = (5.83 +/- 0.15(stat.) +/- 0.30(syst.))%, BF (B0bar -> D^+ l^- anti-nu_l) = (2.21 +/- 0.11(stat.) +/- 0.12(syst.))%, BF (B0bar -> D^*+ l^- anti-nu_l) = (5.49 +/- 0.16(stat.) +/- 0.25(syst.))%, BF (B^- -> D^+ pi^- l^- anti-nu_l) = (0.42 +/- 0.06(stat.) +/- 0.03(syst.))%, BF (B^- -> D^*+ pi^- l^- anti-nu_l) = (0.59 +/- 0.05(stat.) +/- 0.04(syst.))%, BF (B0bar -> D^0 pi^+ l^- anti-nu_l) = (0.43 +/- 0.08(stat.) +/- 0.03(syst.))% and BF (B0bar -> D^*0 pi^+ l^- anti-nu_l) = (0.48 +/- 0.08(stat.) +/- 0.04(syst.))%.

  11. Application of Bayesian population physiologically based pharmacokinetic (PBPK) modeling and Markov chain Monte Carlo simulations to pesticide kinetics studies in protected marine mammals: DDT, DDE, and DDD in harbor porpoises.

    Science.gov (United States)

    Weijs, Liesbeth; Yang, Raymond S H; Das, Krishna; Covaci, Adrian; Blust, Ronny

    2013-05-01

    Physiologically based pharmacokinetic (PBPK) modeling in marine mammals is a challenge because of the lack of parameter information and the ban on exposure experiments. To minimize uncertainty and variability, parameter estimation methods are required for the development of reliable PBPK models. The present study is the first to develop PBPK models for the lifetime bioaccumulation of p,p'-DDT, p,p'-DDE, and p,p'-DDD in harbor porpoises. In addition, this study is also the first to apply the Bayesian approach executed with Markov chain Monte Carlo simulations using two data sets of harbor porpoises from the Black and North Seas. Parameters from the literature were used as priors for the first "model update" using the Black Sea data set, the resulting posterior parameters were then used as priors for the second "model update" using the North Sea data set. As such, PBPK models with parameters specific for harbor porpoises could be strengthened with more robust probability distributions. As the science and biomonitoring effort progress in this area, more data sets will become available to further strengthen and update the parameters in the PBPK models for harbor porpoises as a species anywhere in the world. Further, such an approach could very well be extended to other protected marine mammals.

  12. Higgs Pair Production in the $H(\\rightarrow \\tau\\tau)H(\\rightarrow b\\bar{b})$ channel at the High-Luminosity LHC

    CERN Document Server

    The ATLAS collaboration

    2015-01-01

    Prospects studies are presented for the observation of double Higgs production in the channel $H(\\rightarrow b \\overline{b})H(\\rightarrow \\tau \\tau)$ for a total integrated luminosity of 3000~fb$ ^{-1}$ of $\\sqrt{s}=$14~TeV proton-proton collisions at the HL-LHC. A cut-based analysis strategy using MC data and a parametrisation of the ATLAS detector provide assessment to the measurement prospects performed under different assumptions for the trilinear Higgs couplings values. Assuming SM background and SM signal, we expect to set an upper limit of the cross section for the di-Higgs production of $4.3 \\times \\sigma(HH \\rightarrow b\\bar{b}\\tau^+\\tau^-)$ at 95\\% Confidence Level. Using an effective Lagrangian for the Higgs potential, and allowing its trilinear coupling to vary, we can project an exclusion of $\\lambda_{HHH}/\\lambda_{SM} \\leq -4$ and $\\lambda_{HHH}/\\lambda_{SM} \\geq 12$.

  13. Radiative corrections to the Higgs boson couplings in the Higgs triplet model

    CERN Document Server

    Kikuchi, Mariko

    2013-01-01

    We calculate Higgs coupling constants at one-loop level in the Higgs triplet model (HTM) to compare to future collider experiments. We evaluate the decay rate of the standard model (SM)-like Higgs boson ($h$) into diphoton. Renormalized Higgs couplings with the weak gauge bosons $hVV$ ($V=W$\\ and\\ $Z$) and the trilinear coupling $hhh$ are also calculated at the one-loop level in the on-shell scheme. The event rate of the $pp\\rightarrow h \\rightarrow \\gamma\\gamma$ channel in the HTM to the one in the SM can cover the value from the recent LHC data. We find that in the allowed parameter region by the current data, deviations in the one-loop corrected $hVV$ and $hhh$ vertices can be about -1% and +50%, respectively. Magnitudes of these deviations can be enough significant to compare with the precision future data at the International Linear Collider.

  14. Higgs boson pair production at a photon-photon collision in the two Higgs doublet model

    CERN Document Server

    Asakawa, Eri; Kanemura, Shinya; Okada, Yasuhiro; Tsumura, Koji

    2008-01-01

    We calculate the cross section of Higgs boson pair production at a photon collider in the two Higgs doublet model. We focus on the scenario in which the lightest CP even Higgs boson ($h$) has the standard model like couplings to the gauge bosons. We take into account the one-loop correction to the $hhh$ coupling as well as additional one-loop diagrams due to charged Higgs bosons to the $\\gamma\\gamma\\to hh$ helicity amplitudes. It is found that the full cross section can be enhanced by both these effects to a considerable level. We discuss the impact of these corrections on the $hhh$ coupling measurement at the photon collider.

  15. Dicty_cDB: Contig-U14990-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lekhlkkskkinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkil milkq*hhh*sqnplvavlvki...nl*sskyswyfsnsfny**nxik**lk*kktl Frame B: gllekhlkkskkinikqi*k*kcqvvemvvii*kilaiilkkllfnhqkkqlql*ynkil milkq...qfvqvvqvkmhvnhk liilikrvlkle*kllkiryw*chqrvvlvnqqfhpcyhmvfqreiitppkyly*mlifa vrqfqs*wvlinckl*iqsmvgfhqrcnkqimilk...4 Query: 992 NHDIKVMSVGFLLGTPDAPVIWKGPRKTTMIRRFLKDTFWGKQDYLIIDTPPGTSDEHLS 1171 ++...Contig-U14990-1 no gap 1568 4 3104178 3102621 MINUS 5 8 U14990 0 0 2 0 3 0 0 0 0 0

  16. Effects of Enhanced Oxygen Delivery by Perfluorocarbons in Spinal Cord Injury

    Science.gov (United States)

    2013-10-01

    shown that the pressure of oxygen levels dissolved in the blood in spinal cord injury dropped profoundly from 21.4 to 10.4 mm Hg almost immediately...control the overall type I error of 5%. Data normality was checked in each outcome. SAS 9.2 was used for all analyses . Results Intravenously...which might have beneficial effect, as in the HHH therapy used in treating vasospasm after rupture of an intracranial aneurysm. Also behavioral testing

  17. Residual-based Methods for Controlling Discretization Error in CFD

    Science.gov (United States)

    2015-08-24

    cjroy@vt.edu Co-I: Jeff Borggaard, Interdisciplinary Center for Applied Mathematics , jborggaard@vt.edu Virginia Tech, Blacksburg, Virginia Students...2008). Mathematically rigorous approaches for driving mesh adaptation are discussed in this proposal. Once the strategy for driving the adaption is...GTEE given in Equation (3) gives the continuous residual )()( hhh uuL  (8) which is analogous to the finite element residual (Ainsworth and

  18. Real-Time, General-Purpose, High-Speed Signal Processing Systems for Underwater Research. Proceedings of a Working Level Conference held at Supreme Allied Commander, Atlantic, Anti-Submarine Warfare Research Center (SACLANTCEN) on 18-21 September 1979. Part 1. Sessions I to III.

    Science.gov (United States)

    1979-12-01

    radar processiag (h) 8-1 to 8-6 by RKa-J~rgem Alker NARTIE - Hultiprocesser for high capacity real-time processing i 91 to 94 by TaSgvr Lumdh A modular...H * CREATE REFL. COEF. FOR RAYTRACE ........ * ...................... * * I * DISPLtA REFL. COEF FOR RAYTRACE ...IEEEEEEEEEEEEE Emlllllllllllu -EEIIIIIEEEEE -- Eh~~hh~h ALKER: Correlator for radar processing A MICRO-PROGRAMMABLE CORRELATOR FOR REAL-TIME RADAR

  19. Standardized UXO Technology Demonstration Site, Scoring Record No. 944

    Science.gov (United States)

    2014-08-01

    R xz R yz R y R xy R xz R xy R x mmm R HHH zyxzyx  where mx , my, and mz are the object principal polarizabilities scaled by the transmitter...An APG weather station located approximately 1 mile west of the test site was used to record average temperature and precipitation on a half-hour...hours, while precipitation data represent a daily total amount of rainfall. Hourly weather logs used to generate this summary are provided in Appendix

  20. The effects of a language barrier in a South African district hospital.

    Science.gov (United States)

    Schlemmer, A; Mash, B

    2006-10-01

    Communication between health workers and patients at Hottentots Holland Hospital (HHH) is hindered by staff and patients not speaking the same language. HHH is a district hospital in the Cape Town Metropolitan District of the Western Cape where staff mainly speak Afrikaans or English and a large number of patients mainly Xhosa. The study aimed to explore the effects of this language barrier on health workers and patients at HHH. Three focus group interviews were held with 21 members of staff and 5 in-depth patient interviews were conducted. The language barrier was found to interfere with working efficiently, create uncertainty about the accuracy of interpretation, be enhanced by a lack of education or training, cause significant ethical dilemmas, negatively influence the attitudes of patients and staff towards each other, decrease the quality of and satisfaction with care, and cause cross-cultural misunderstandings. The effects of the language barrier were considerable and persistent despite an official language policy in the province. The training and employment of professional interpreters as well as teaching of basic Xhosa to staff are recommended.

  1. Tuning the decay time of lanthanide-based near infrared luminescence from micro- to milliseconds through d-->f energy transfer in discrete heterobimetallic complexes.

    Science.gov (United States)

    Torelli, Stéphane; Imbert, Daniel; Cantuel, Martine; Bernardinelli, Gérald; Delahaye, Sandra; Hauser, Andreas; Bünzli, Jean-Claude G; Piguet, Claude

    2005-05-20

    Inert and optically active pseudo-octahedral Cr(III)N6 and Ru(II)N6 chromophores have been incorporated by self-assembly into heterobimetallic triple-stranded helicates HHH-[CrLnL3]6+ and HHH-[RuLnL3]5+. The crystal structures of [CrLnL(3)](CF(3)SO(3))(6) (Ln=Nd, Eu, Yb, Lu) and [RuLnL3](CF3SO3)5 (Ln=Eu, Lu) demonstrate that the helical structure can accommodate metal ions of different sizes, without sizeable change in the intermetallic MLn distances. These systems are ideally suited for unravelling the molecular factors affecting the intermetallic nd-->4f communication. Visible irradiation of the Cr(III)N6 and Ru(II)N6 chromophores in HHH-[MLnL3]5/6+ (Ln=Nd, Yb, Er; M=Cr, Ru) eventually produces lanthanide-based near infrared (NIR) emission, after directional energy migration within the complexes. Depending on the kinetic regime associated with each specific d-f pair, the NIR luminescence decay times can be tuned from micro- to milliseconds. The origin of this effect, together with its rational control for programming optical functions in discrete heterobimetallic entities, are discussed.

  2. An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.

    Directory of Open Access Journals (Sweden)

    Tianqiao Song

    2015-12-01

    Full Text Available Oomycete pathogens produce a large number of CRN effectors to manipulate plant immune responses and promote infection. However, their functional mechanisms are largely unknown. Here, we identified a Phytophthora sojae CRN effector PsCRN108 which contains a putative DNA-binding helix-hairpin-helix (HhH motif and acts in the plant cell nucleus. Silencing of the PsCRN108 gene reduced P. sojae virulence to soybean, while expression of the gene in Nicotiana benthamiana and Arabidopsis thaliana enhanced plant susceptibility to P. capsici. Moreover, PsCRN108 could inhibit expression of HSP genes in A. thaliana, N. benthamiana and soybean. Both the HhH motif and nuclear localization signal of this effector were required for its contribution to virulence and its suppression of HSP gene expression. Furthermore, we found that PsCRN108 targeted HSP promoters in an HSE- and HhH motif-dependent manner. PsCRN108 could inhibit the association of the HSE with the plant heat shock transcription factor AtHsfA1a, which initializes HSP gene expression in response to stress. Therefore, our data support a role for PsCRN108 as a nucleomodulin in down-regulating the expression of plant defense-related genes by directly targeting specific plant promoters.

  3. Anomalous $\\omega$-$Z$-$\\gamma$ Vertex from Hidden Local Symmetry

    CERN Document Server

    Harada, Masayasu; Yamawaki, Koichi

    2011-01-01

    We formulate the general form of omega-Z-gamma vertex in the framework based on the hidden local symmetry (HLS), which arises from the gauge invariant terms for intrinsic parity-odd (IP-odd) part of the effective action. Those terms are given as the homogeneous part of the general solution (having free parameters) to the Wess-Zumino (WZ) anomaly equation and hence are not determined by the anomaly, in sharp contrast to the Harvey-Hill-Hill (HHH) action where the relevant vertex is claimed to be uniquely determined by the anomaly. We show that, even in the framework that HHH was based on, the omega-Z-gamma vertex is actually not determined by the anomaly but by the homogeneous (anomaly-free) part of the general solution to the WZ anomaly equation having free parameters in the same way as in the HLS formulation: The HHH action is just a particular choice of the free parameters in the general solution. We further show that the omega-Z-gamma vertex related to the neutrino (nu) - nucleon (N) scattering cross secti...

  4. Modelling large-scale halo bias using the bispectrum

    CERN Document Server

    Pollack, Jennifer E; Porciani, Cristiano

    2011-01-01

    We study the relation between the halo and matter density fields -- commonly termed bias -- in the LCDM framework. In particular, we examine the local model of biasing at quadratic order in matter density. This model is characterized by parameters b_1 and b_2. Using an ensemble of N-body simulations, we apply several statistical methods to estimate the parameters. We measure halo and matter fluctuations smoothed on various scales and find that the parameters vary with smoothing scale. We argue that, for real-space measurements, owing to the mixing of wavemodes, no scale can be found for which the parameters are independent of smoothing. However, this is not the case in Fourier space. We measure halo power spectra and construct estimates for an effective large-scale bias. We measure the configuration dependence of the halo bispectra B_hhh and reduced bispectra Q_hhh for very large-scale k-space triangles. From this we constrain b_1 and b_2. Using the lowest-order perturbation theory, we find that for B_hhh the...

  5. Radiative corrections to the Higgs boson couplings in the triplet model

    CERN Document Server

    Aoki, Mayumi; Kikuchi, Mariko; Yagyu, Kei

    2012-01-01

    We calculate a full set of one-loop corrections to the Higgs boson coupling constants as well as the electroweak parameters. We compute the decay rate of the standard model (SM)-like Higgs boson ($h$) into diphoton. Renormalized Higgs couplings with the weak gauge bosons $hVV$ ($V=W$ and $Z$) and the trilinear coupling $hhh$ are also calculated at the one-loop level in the on-shell scheme. Magnitudes of the deviations in these quantities are evaluated in the parameter regions where the unitarity and vacuum stability bounds are satisfied and the predicted W boson mass at the one-loop level is consistent with the data. We find that there are strong correlations among deviations in the Higgs boson couplings $h\\gamma\\gamma$, $hVV$ and $hhh$. For example, if the event number of the $pp\\to h\\to\\gamma\\gamma$ channel deviates by +30% (-40%) from the SM prediction, deviations in the one-loop corrected $hVV$ and $hhh$ vertices are predicted about -0.1% (-2%) and -10% $(+150%)$, respectively. The model can be discrimina...

  6. Fitting the Two-Higgs-Doublet model of type II

    CERN Document Server

    Eberhardt, Otto

    2014-01-01

    We present the current status of the Two-Higgs-Doublet model of type II. Taking into account all available relevant information, we exclude at $95$% CL sizeable deviations of the so-called alignment limit, in which all couplings of the light CP-even Higgs boson $h$ are Standard-Model-like. While we can set a lower limit of $240$ GeV on the mass of the pseudoscalar Higgs boson at $95$% CL, the mass of the heavy CP-even Higgs boson $H$ can be even lighter than $200$ GeV. The strong constraints on the model parameters also set limits on the triple Higgs couplings: the $hhh$ coupling in the Two-Higgs-Doublet model of type II cannot be larger than in the Standard Model, while the $hhH$ coupling can maximally be $2.5$ times the size of the Standard Model $hhh$ coupling, assuming an $H$ mass below $1$ TeV. The selection of benchmark scenarios which maximize specific effects within the allowed regions for further collider studies is illustrated for the $H$ branching fraction to fermions and gauge bosons. As an exampl...

  7. Non-decoupling effects in supersymmetric Higgs sectors

    CERN Document Server

    Kanemura, Shinya; Yagyu, Kei

    2010-01-01

    A wide class of Higgs sectors is comprehensively investigated in the decoupling region in supersymmetric standard models. The mass ($m_h$) of the lightest Higgs boson ($h$) as well as the triple Higgs boson coupling (the $hhh$ coupling) are evaluated at the one-loop level in each model. While $m_h$ is at most 120-130 GeV in the minimal supersymmetric standard model (MSSM), that in models with an additional singlet or triplet fields can be much larger. The $hhh$ coupling can also be sensitive to the models: while in the MSSM the deviation from the standard model prediction is not significant, that can be 30-60 \\% in some models such as that with the additional singlet or with extra doublets and charged singlets. These models are motivated by specific physics problems. Therefore, when $h$ is found at the CERN Large Hadron Collider, we may be able to discriminate supersymmetric models by measuring $m_h$ and the $hhh$ coupling accurately at future collider experiments.

  8. Neutral Higgs Boson Pair-Production and Trilinear Self-Couplings in the MSSM at ILC and CLIC Energies

    CERN Document Server

    Gutiérrez-Rodríguez, A; Sampayo, O A

    2009-01-01

    We study pair-production as well as the triple self-couplings of the neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) at the Future International Linear $e^{+}e^{-}$ Collider (ILC) and Compact Linear Collider (CLIC). The analysis is based on the reactions $e^{+}e^{-}\\to b \\bar b h_ih_i, t \\bar t h_ih_i$ with $h_i=h, H, A$. We evaluate the total cross-section for both $b\\bar bh_ih_i$, $t\\bar th_ih_i$ and calculate the total number of events considering the complete set of Feynman diagrams at tree-level. We vary the triple couplings $\\kappa\\lambda_{hhh}$, $\\kappa\\lambda_{Hhh}$, $\\kappa\\lambda_{hAA}$, $\\kappa\\lambda_{HAA}$, $\\kappa\\lambda_{hHH}$ and $\\kappa\\lambda_{HHH}$ within the range $\\kappa=-1$ and +2. The numerical computation is done for the energies expected at the ILC with a center-of-mass energy 500, 1000, 1600 $GeV$ and a luminosity 1000 $fb^{-1}$. The channels $e^{+}e^{-}\\to b \\bar b h_ih_i$ and $e^{+}e^{-}\\to t \\bar t h_ih_i$ are also discussed to a center-of-mass energy of 3...

  9. The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition.

    Science.gov (United States)

    Das, Devashish; Folkers, Gert E; van Dijk, Marc; Jaspers, Nicolaas G J; Hoeijmakers, Jan H J; Kaptein, Robert; Boelens, Rolf

    2012-04-01

    Human XPF/ERCC1 is a structure-specific DNA endonuclease that nicks the damaged DNA strand at the 5' end during nucleotide excision repair. We determined the structure of the complex of the C-terminal domain of XPF with 10 nt ssDNA. A positively charged region within the second helix of the first HhH motif contacts the ssDNA phosphate backbone. One guanine base is flipped out of register and positioned in a pocket contacting residues from both HhH motifs of XPF. Comparison to other HhH-containing proteins indicates a one-residue deletion in the second HhH motif of XPF that has altered the hairpin conformation, thereby permitting ssDNA interactions. Previous nuclear magnetic resonance studies showed that ERCC1 in the XPF-ERCC1 heterodimer can bind dsDNA. Combining the two observations gives a model that underscores the asymmetry of the human XPF/ERCC1 heterodimer in binding at an ss/ds DNA junction.

  10. An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.

    Science.gov (United States)

    Song, Tianqiao; Ma, Zhenchuan; Shen, Danyu; Li, Qi; Li, Wanlin; Su, Liming; Ye, Tingyue; Zhang, Meixiang; Wang, Yuanchao; Dou, Daolong

    2015-12-01

    Oomycete pathogens produce a large number of CRN effectors to manipulate plant immune responses and promote infection. However, their functional mechanisms are largely unknown. Here, we identified a Phytophthora sojae CRN effector PsCRN108 which contains a putative DNA-binding helix-hairpin-helix (HhH) motif and acts in the plant cell nucleus. Silencing of the PsCRN108 gene reduced P. sojae virulence to soybean, while expression of the gene in Nicotiana benthamiana and Arabidopsis thaliana enhanced plant susceptibility to P. capsici. Moreover, PsCRN108 could inhibit expression of HSP genes in A. thaliana, N. benthamiana and soybean. Both the HhH motif and nuclear localization signal of this effector were required for its contribution to virulence and its suppression of HSP gene expression. Furthermore, we found that PsCRN108 targeted HSP promoters in an HSE- and HhH motif-dependent manner. PsCRN108 could inhibit the association of the HSE with the plant heat shock transcription factor AtHsfA1a, which initializes HSP gene expression in response to stress. Therefore, our data support a role for PsCRN108 as a nucleomodulin in down-regulating the expression of plant defense-related genes by directly targeting specific plant promoters.

  11. Strain-induced Fermi contour anisotropy of GaAs (311)A 2D holes

    Science.gov (United States)

    Shabani, Javad; Shayegan, Mansour; Winkler, Roland

    2008-03-01

    There is considerable current interest in electronic properties of two-dimensional (2D) carriers whose energy bands are spin-split at finite values of in-plane wave vector, thanks to the spin-orbit interaction and the lack of inversion symmetry. We report experimental and theoretical results revealing that the spin-subband Fermi contours of the heavy and light heavy-holes (HHh and HHl) can be tuned in high mobility GaAs (311)A 2D hole systems via the application of symmetry-breaking in-plane strain. Our calculations show that the HHl spin-subband Fermi contour is circular but the HHh spin-subband Fermi contour is distorted. Experimentally, we probe the Fermi contour anisotropy by measuring the magneto-resistance commensurability peaks induced by square arrays of antidots. When the spin splitting is sufficiently large, the magneto-resistance trace exhibits two peaks, providing clear evidence for spin-resolved ballistic transport. The experimental results are in good agreement with the calculations, and confirm that the majority spin-subband (HHh) has a severely distorted Fermi contour whose anisotropy can be tuned with strain while Fermi contour of the minority spin-subband (HHl) remains nearly isotropic.

  12. Prevalence of supraventricular arrhythmias from the automated analysis of data stored in the DDD pacemakers of 617 patients: the AIDA study. The AIDA Multicenter Study Group. Automatic Interpretation for Diagnosis Assistance.

    Science.gov (United States)

    Defaye, P; Dournaux, F; Mouton, E

    1998-01-01

    The confirmation of the occurrence of supraventricular arrhythmias (SVAs) is possible only if a surface electrocardiogram (ECG) is recorded during an episode, or if SVAs occur during 24 h ambulatory monitoring (Holter). The automatic interpretation of memory functions in DDD pacemakers may be useful in this diagnostic task over longer periods of follow up. This hypothesis was tested in 384 men and 233 women (mean age = 70 +/- 11 years) who had received Chorus 6034/6035, 6234 or 7034 pacemakers (ELA Medical, Montrouge, France) with fall-back function in case of sustained SVAs. The Automatic Interpretation for Diagnostic Assistance (AIDA) algorithm included in these pacemakers was compared with 24 h Holters recorded simultaneously (D1) and with the clinical history of symptoms consistent with SVAs up to 28 days of follow up (D28). Indications for pacing were atrioventricular block (AVB) in 269 patients, sinus node dysfunction (SND) in 248, and AVB + SND in 100. SVAs were documented before implant in 199 patients (32%). Among the 617 patients included at D1, 76 (12.4%) developed at least one SVA episode, lasting between 1 min and 24 hours, simultaneously recorded on Holter and by AIDA with a 93.8% sensitivity and 94.2% specificity. Data from 354 patients were available for analysis at D28. AIDA diagnosed SVAs in 179 patients (50.6%), 104 of whom (65%) had remained asymptomatic and 117 of whom (65%) had had no SVA documented before implant. Among the 354 patients, AIDA diagnosed SVAs in 76 (21%) asymptomatic patients who had no known SVA before implant. The prevalence of SVA in our AVB population was higher than reported in previous studies: 89 patients (56.3%) with AVB had SVAs versus 90 patients (45.9%) with other diagnoses (p = 0.55). Furthermore atrial pacing was associated with fewer SVAs. These first clinical results of the AIDA study demonstrate that the memory functions of Chorus pacemakers and the AIDA software are reliable to analyze the prevalence of SVA at

  13. Efeitos da mudança de modo de estimulação ventricular para atrioventricular sobre a qualidade de vida em pacientes com cardiopatia chagásica e bloqueio atrioventricular na troca eletiva do gerador de pulsos Health-related quality of life in patients with Chagas' cardiomiopathy and complete atrioventricular block at elective pulse generator replacement: effects of pacing mode upgraded from VVI to DDD

    Directory of Open Access Journals (Sweden)

    Luiz Antonio Castilho Teno

    2005-03-01

    Full Text Available OBJETIVO: Avaliar os efeitos da mudança de modo de estimulação ventricular para atrioventricular sobre a qualidade de vida em pacientes com cardiopatia chagásica e bloqueio atrioventricular, na troca eletiva do gerador de pulsos. MÉTODO: No período de 8 de setembro de 2001 a 18 de março de 2004, no Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo e no Hospital de Beneficência Portuguesa de Ribeirão Preto, foram estudados comparativamente sob estimulação ventricular e atrioventricular 27 pacientes com cardiopatia chagásica e bloqueio atrioventricular, com indicação de troca eletiva do gerador de pulsos. Os pacientes foram analisados na inclusão do estudo e alternadamente no modo ventricular e atrioventricular em duas fases com duração de 90 dias, considerando-se o comportamento clínico, avaliado pela qualidade de vida. A análise estatística foi realizada na condição basal, modo VVI e modo DDD, utilizando-se o teste de variância para medidas repetidas, considerando-se nível de significância de 0,05. RESULTADOS: Não foram detectadas diferenças de comportamento na qualidade de vida, avaliada pela capacidade funcional pelo estado geral e pela vitalidade, entre os dois modos de estimulação cardíaca estudados. Ocorreram três casos de complicações relacionadas à mudança de modo de estimulação: dois casos de taquiarritmias atriais conduzidas pelo marcapasso e um caso de deslocamento de eletrodo atrial. CONCLUSÕES: A análise comparativa da estimulação ventricular com a atrioventricular, na troca eletiva do gerador, demonstrou que não houve diferença de comportamento clínico sobre a qualidade de vida.OBJECTIVE: Health-related quality of life in patients with Chagas' cardiomyopathy and complete atrioventricular block at elective pulse generator replacement: effects of pacing mode upgraded from VVI to DDD. METHOD: From September 8, 2001 to March 18, 2004, at the Instituto do Cora

  14. Comparative analysis of agricultural drought monitoring based on climate and soil moisture indicators in the Huang-Huai-Hai Plain of China

    Science.gov (United States)

    Wu, J.; Zhou, H.; An, X.

    2016-12-01

    Agricultural drought is one of very common agro-meteorological disasters, having a serious threat on crop growth and production. Effective drought monitoring will aid the drought response management to reduce drought loss. Currently there has been many drought indices used for agricultural drought monitoring. Climate-based Standardized Precipitation Evapotranspiration Index (SPEI) was widely used for agricultural drought monitoring in view of its merits of simple calculation, multi-scale and with consideration of evapotranspiration. Besides, soil moisture has been recognized as the most direct indicator for monitoring agricultural drought, which provides a huge potential for monitoring due to the increase of soil moisture accessibility. Given that algorithms of both indices are different and their monitoring results also may exist the discrepancies, it is necessary to analyze their performances of both indices in agricultural drought monitoring. In this study, we chose the climate-based SPEI and soil moisture-based index (SMI) to analyze. Firstly, drought events identified by SPEI and SMI were analyzed from the perspective of drought evolution. Then the performances of SPEI and SMI were assessed through the comparison with observed drought events. Finally, vegetation change since 2000 and impact of drought on vegetation growth in Huang-Huai-Hai (HHH) Plain were explored based on MODIS NDVI data. The results show that SPEI-based drought trend agrees with SMI-based analysis, demonstrating that drought has an alleviating trend in HHH Plain in recent years. The SPEI and SMI could identify most of drought events, whereas the SMI has better performance than SPEI when it comes to drought category. The NDVI in HHH Plain shows an upward trend since 2000 and drought occurred in 2000 causes a decline in vegetation vigor. Both the SPEI and SMI are significantly correlated with NDVI anomaly, and correlation between SMI and NDVI anomaly is slightly higher than that of SPEI.

  15. Effects of VAT and DDD pacing on left cardiac function in the patients of high right ventricular septal pacing with third degree atrioventricular block%Ⅲ度房室传导阻滞患者高位右室间隔部起搏VAT与DDD模式对左心功能的影响

    Institute of Scientific and Technical Information of China (English)

    王燕; 章蓉; 王旭; 邵一兵

    2012-01-01

    目的 通过研究Ⅲ度房室传导阻滞患者高位右室间隔部起搏( HRVS)时,VAT与DDD模式对心功能的影响,探讨心房的生理收缩和舒张对左心功能的作用.方法 32例Ⅲ度房室传导阻滞患者,在HRVS时,分别给予DDD模式或VAT模式工作,于调控即刻通过超声心动图测定二尖瓣口快速充盈期峰值血流速度(Ep),二尖瓣口左房收缩期峰值血流速度(Ap),二尖瓣环后壁处收缩期脉冲组织多普勒峰值速度平均值(Vs),二尖瓣环后壁处舒张早期脉冲组织多普勒峰值速度平均值(Ve),二尖瓣环后壁处舒张晚期脉冲组织多普勒峰值速度平均值(Va),二尖瓣血流频谱等容舒张时间(IVRT),通过Ep/Ap,Ve/Va,Ep/Ve和IVRT评价左室舒张功能,通过Vs,LVEF和LVFS评价收缩功能.结果 HRVS时DDD较VAT模式Ep/Ap、Ve/Va、Ep/Ve,IVRT差异有显著性(0.97 ±0.11 vs 1.01±0.11,0.89 ±0.09 vs 0.97 ±0.07,6.00 ±0.45 vs 6.24 ±0.36,100.4±14.32 vs 89.99 ±7.94;P均<0.01),Vs、左室射血分数和左室短轴缩短率无显著性差异.结论 Ⅲ度房室传导阻滞时,HRVS起搏时,DDD模式较VAT模式使左室舒张功能下降,收缩功能无影响,表明了心房生理性起搏的重要性.%Objective To analyze the effects of physiologic systole and diastole of atrium, through the influence of VAT and DDD pacing mode on left cardiac function in patients of high right ventricular septal( HRVS) pacing with third degree atrioventricular block. Methods Thirty-two patients of HRVS pacing with third degree atrioventricular block with pacemaker mode of VAT or DDD underwent complete standard echocardiography (2D,M-mode, pulsed Doppler) and PW-DTI. Transmitral inflow velocity Ep and Ap, peak systolic velocity ( Vs ) , peak early diastolic velocity ( Ve) , peak late diastolic velocity (Va) of posterior mitral annulus and the isovolumic relaxation time(IVRT) were obtained . Then left ventricular diastolic function were evaluated through Ep/Ap, Ve/Va and Ep

  16. Studies of the ATLAS potential for Higgs self-coupling measurements at a High Luminosity LHC

    CERN Document Server

    ATLAS, Collaboration; The ATLAS collaboration

    2013-01-01

    Studies are presented on the prospects of measuring the Higgs trilinear self-coupling λHHH in 3,000 fb−1 of 14 TeV proton-proton collisions at the HL-LHC. Two channels are discussed: H(→ bb)H(→ W+W−) and H(→ bb)H(→ γγ). Generator-level Monte Carlo events are used to perform these studies, with parameterised efficiencies and smearings applied to approximate the expected detector performance under HL-LHC conditions.

  17. Measurement and modeling of acid dissociation constants of tri-peptides containing Glu, Gly, and His using potentiometry and generalized multiplicative analysis of variance.

    Science.gov (United States)

    Khoury, Rima Raffoul; Sutton, Gordon J; Hibbert, D Brynn; Ebrahimi, Diako

    2013-02-28

    We report pK(a) values with measurement uncertainties for all labile protons of the 27 tri-peptides prepared from the amino acids glutamic acid (E), glycine (G) and histidine (H). Each tri-peptide (GGG, GGE, GGH, …, HHH) was subjected to alkali titration and pK(a) values were calculated from triplicate potentiometric titrations data using HyperQuad 2008 software. A generalized multiplicative analysis of variance (GEMANOVA) of pK(a) values for the most acidic proton gave the optimum model having two terms, an interaction between the end amino acids plus an isolated main effect of the central amino acid.

  18. Status of Knowledge of Radiation Embrittlement in USA Reactor Pressure Vessel Steels.

    Science.gov (United States)

    1982-02-01

    NRC-FIN-5528 UNCLASSIFIED NRL-R-,737 NUREG -CR-2511 Ni." EEEIIEIIIEI mEE/hhhE AD ~ NUREG /CR-251 1 0 AD A I INRL Memo Rpt 4737 Status of Knowledge of...J2.75 ti a Tec nica for ati Irv Ce Spr ~~~ Sid 1 NUREG /CR-2511 NRL Memo Rpt 4737 R5 Status of Knowledge of Radiation Embrittlement in USA Reactor...vendor reports and correspondence; Commission papers; and applicant and licensee documents and correspondence. The following documents in the NUREG

  19. X-ray diffraction investigations of adherent and free standing TiN coatings deposited by magnetron sputtering

    Energy Technology Data Exchange (ETDEWEB)

    Valvoda, V.; Kuzel, R. Jr.; Dobiasova, L.; Cerny, R. (Charles Univ., Prague (Czechoslovakia). Faculty of Mathematics and Physics); Poulek, V.; Musil, J. (Czechoslovak Academy of Sciences, Prague (Czechoslovakia). Inst. of Physics)

    1990-06-01

    TiN coatings deposited on steel substrates at different biases and temperatures, and with different nitrogen contents, were studied by conventional X-ray powder diffractometry. The diffraction peaks were separated by profile fitting. In adherent films different kinds of texture and a large anisotropy of lattice parameters (a(hhh) < a(h00) < a(hh0)) were detected. In corresponding free-standing films lower average values of lattice parameters were found and their anisotropy decreased considerably. The microstrain determined from X-ray line broadening remained unchanged, which proves its inelastic nature owing to the lattice defects.

  20. On the Taylor Approximation of Control Systems.

    Science.gov (United States)

    1984-01-01

    80-C-0041 UNCLASIFIED 12/EhE~hhhEID S11U MICROCOPY RESOLUTION TEST CHART NATIONAL BUREAU OF STANDARDS-0963.A tliLi ~ ii : MRC Technical Summary Report...control systems, Picard iterates, Taylor expansion. Work Unit Number 5 (Optimization and Large Scale Systems) Istituto di Matematica Applicata...control system on Ad: I _~~d x~)= m g(x(t))ou (t), x(o) = O ii 1 Given a control u, in general there exists no explicit formula to exactly compute the

  1. 78 FR 71510 - Delegation of Authority to the States of Iowa; Kansas; Missouri; Nebraska; Lincoln-Lancaster...

    Science.gov (United States)

    2013-11-29

    ... November 7, 2006. HHH Synthetic Fiber 06/28/11 07/01/08 6/30/11 07/01/09 Production 10/24/12 11/05/10 12/30.../11 07/01/09 07/01/11 Vegetable Oil 10/24/12 12/28/12 12/30/12 12/22/12 09/28/10 04/02/12 Production... 07/01/11 Fibers Production. 10/24/12 12/28/12 12/30/12 12/22/12 MMMMMM Carbon Black 9/19/11 07/01/10...

  2. Quimera de ADN polimerasa del fago ϕ29

    OpenAIRE

    2010-01-01

    Quimera de ADN polimerasa del fago 29. La presente invención se encuadra dentro del campo de la biotecnología. Específicamente, se refiere a una quimera de ADN polimerasa que comprende una región aminoterminal (N-terminal), que codifica para una ADN polimerasa del tipo 29, y una región carboxilo-terminal (C-terminal), que comprende, al menos, un dominio HhH, que se encuentran unidas mediante una secuencia aminoacídica conectora y a su uso para la replicación, amplifi...

  3. Triple Higgs boson production at a 100 TeV proton-proton collider

    CERN Document Server

    Papaefstathiou, Andreas

    2016-01-01

    We consider triple Higgs boson production at a future 100 TeV proton-proton collider. We perform a survey of viable final states and compare and contrast triple production to Higgs boson pair production. Focussing on the $hhh \\rightarrow (b\\bar{b}) (b\\bar{b}) (\\gamma \\gamma)$ final state, we construct a baseline analysis for the Standard Model scenario and simple deformations, demonstrating that the process merits investigation in the high-luminosity phase of the future collider as a new probe of the self-coupling sector of the Higgs boson.

  4. Sensitivity of the decay $h\\to ZZ^*\\to Zl+l-$ to the Higgs self coupling through radiative corrections

    CERN Document Server

    Castilla-Valdez, H; Moyotl, A; Perez, M A

    2015-01-01

    We study the radiative corrections induced by the triple Higgs boson coupling $hhh$ in the three body decay $h\\to ZZ^*\\to Zl\\bar l$. We show that these corrections are potentially sensitive to the specific value of this coupling in the Standard Model and the Two Higgs Doublet Model. These effects may induce corrections to the integrated decay width of the three-body decay of order few percent and thus open a new window to test the Higgs boson self interaction.

  5. 心力衰竭患者中生命体征和心肺信号的家庭远程监控:HHH模式的系统结构和可行性

    Institute of Scientific and Technical Information of China (English)

    Pinna; G.D.; Maestri; R.; Andrews; D.; 王亭忠

    2007-01-01

    背景:心力衰竭的家庭或医院干预研究(HHH)是一项欧洲社区资助性试验(QLGA-CT-2001-02424),这项多中心、多国家(意大利、波兰和英国)、随机对照临床试验比较了心力衰竭(HF)常规干预与三种HF家庭干预。对临床参数进行家庭远程监控(HT)是传

  6. Study of Improved Aluminum Materials for Vehicular Armor

    Science.gov (United States)

    1977-04-07

    103 B17 Procedures Used to Evaluate FTMT Practices on 1.25" Thick 7475 Plate ------------------------------------ 104 B18...and final artificial aging at 250*F for 8, 16, or 24 hrs. The fabricating details are civen in Figure B17 in Appendix B. Grain Size Determinations...rd H WCU 40a) 9 ;,-4d) H4)Q ill 4)1 a, 4.) 4o n 2 0- U) 00l 4U 4 4-40 4 0HHH 4) 4) W0n rd 0 >~4 :z £ 0 4J ( 0 9 0 W E I O OHr 4) -4 H) Wit , H 4 ) H 4

  7. Autism Spectrum Disorders: A Natural Fit with DDD.

    Science.gov (United States)

    Myles, Brenda Smith; Simpson, Richard L.; Babkie, Andrea M.

    2003-01-01

    This position statement from the Critical Issues Committee of the Developmental Disabilities Division of the Council for Exceptional Children focuses on clarifying the place of autism spectrum disorders within the field of developmental disabilities. The representation of concerns relating to autism spectrum disorders by the Developmental…

  8. Fehlprogrammierung der frequenzadaptiven Parameter eines DDD-R-Schrittmachers

    Directory of Open Access Journals (Sweden)

    Wimmer L

    2000-01-01

    Full Text Available Aufgrund einer chronotropen Inkompetenz wurde bei einem 58jährigen Patienten ein frequenzadaptiver Schrittmacher implantiert. Nach Implantation kam es unerwarteterweise zu keiner Verbesserung der klinischen Beschwerdesymptomatik. In den verschiedensten kardiologischen Spezialabteilungen wurden mehrere erfolglose Neuprogrammierungen vorgenommen. Schlußendlich konnte durch Erhöhung des Anstiegsfaktors des Akzelerometers eine prompte Beschwerdefreiheit erzielt werden. Die meisten Sensoren stellen mit der Aktivität die Akzelerometer dar. Es handelt sich dabei um einen piezoelektrischen Kristall, der auf Beschleunigungsänderungen reagiert. Sehr oft kann durch einfache Änderungen der Programmierung entscheidend die Lebensqualität für den Patienten verbessert werden.

  9. DDT, DDD, AND DDE DECHLORINATION BY ZERO-VALENT IRON

    Science.gov (United States)

    Traditionally, destruction of DDT [1,1,1-trichIoro-2,2-bis(p-chlorophenyl)ethane] for environmental remediation required high-energy processes such as incineration. Here, the capability of powdered zero-valent iron to dechlorinate DDT and related compounds at room tempera...

  10. Facilitation of DDD follow-up using the DDT mode.

    Science.gov (United States)

    Kamke, W; Nitschke, M; Gutschker, A; Worzewski, W

    1992-11-01

    To facilitate follow-up, modern dual chamber pacemakers provide a variety of diagnostic features like ECG interpretation channels and intracardiac electrograms. For evaluation of the sensing performance at rest and during exercise, for assessment of the presence of crosstalk, and for measurement of the retrograde conduction time, dual chamber triggered pacing, particularly the DDT mode, can be used alternatively or additionally in pacemakers equipped with this option. In contrast to ECG interpretation channels, ECG documentation is not required for evaluation of the sensing performance, because the triggered pulses serving as markers for sense events can also be seen on the monitor. Selection of the DDT mode not only as temporary but also as permanent program serves to facilitate pacemaker ECG interpretation for exercise tests and Holter recordings as well.

  11. Comparative study on new cyanide-resistant DDD and 4-diaminophenol in methylhemoglobin forming ability%抗氰新药DDD和4-二甲基氨基苯酚对大鼠高铁血红蛋白浓度的影响

    Institute of Scientific and Technical Information of China (English)

    林海; 蔡颖; 但国蓉; 董兆君

    2014-01-01

    目的 通过比较4-二甲基氨基苯酚(4-DMAP)和DDD对大鼠血液高铁血红蛋白(MeHb)浓度的影响,排除DDD形成MeHb的可能性,为该药的安全使用提供试验依据.方法 将大白鼠70只分成两组,分别进行时间-效应试验和量-效试验.时效试验中大鼠分别口服DDD或4-DMAP,于10、30、60min取血样测定MeHb浓度;剂量-效应试验中大鼠口服不同剂量DDD或腹腔注射不同剂量4-DMAP,于30min取血样用铁氰化钾法测定MeHb浓度.结果 时-效试验中,4-DMAP引起大鼠血液MeHb浓度显著升高,DDD不引起MeHb浓度变化,给DDD 10、30、60min后,大鼠血液MeHb分别为2.87±0.32、2.42±0.19、2.56±0.41,给4-DMAP10、30、60min后,大鼠血液MeHb分别为8.62±0.93、22.47±3.67、19.33±4.12,与对照组比较P<0.05.量效试验中,1、2、3mg/kg的4-DMAP造成大鼠血液MeHb以量效依赖方式升高,大鼠血液MeHb分别为18.54±2.93、22.47±3.67、31.08±4.04,50、100、150mg/kg的DDD不引起大鼠血液MeHb浓度变化,大鼠MeHb分别为2.35±0.44、2.42±0.19、2.71±0.42.结论 4-DMAP是MeHb形成剂,DDD不具备形成MeHb的能力.

  12. One-loop corrections to the Higgs self-couplings in the singlet extension

    CERN Document Server

    Kanemura, Shinya; Yagyu, Kei

    2016-01-01

    We investigate predictions on the triple Higgs boson couplings with radiative corrections in the model with an additional real singlet scalar field. In this model, the second physical scalar state ($H$) appears in addition to the Higgs boson ($h$) with the mass 125 GeV. The $hhh$ vertex is calculated at the one-loop level, and its possible deviation from the predictions in the standard model is evaluated under various theoretical constraints. The decay rate of $H \\to hh$ is also computed at the one-loop level. We also take into account the bound from the precise measurement of the $W$ boson mass, which gives the upper limit on the mixing angle $\\alpha$ between two physical Higgs bosons for a given value of the mass of $H$ ($m_H^{}$). We find that the deviation in the $hhh$ coupling from the prediction in the standard model can maximally be about 250\\%, 150\\% and 75\\% for $m_H^{}=300$, 500 and 1000 GeV, respectively, under the requirement that the cutoff scale of the model is higher than 3 TeV. We also discuss...

  13. One-Loop Radiative Correction to the Triple Higgs Coupling in the Higgs Singlet Model

    CERN Document Server

    He, Shi-Ping

    2016-01-01

    Though the 125 GeV Higgs boson is consistent with the standard model (SM) prediction until now, the triple coupling can deviate from the SM value in the physics beyond the SM (BSM). In this paper, the radiative correction to the triple Higgs coupling is calculated in the minimal extension of the SM by adding a real gauge singlet scalar. In this model there are two scalars $h$ and $H$ and both of them are mixed states of the doublet and singlet. Provided that the mixing angle is set to be zero, $h$ is the pure left-over of the doublet and its behavior is the same as that of the SM except the triple $h$ couping. In this SM limit case, the effect of the singlet $H$ will decouple from the fermions and gauge bosons, and firstly shown up in the triple $h$ coupling. Our numerical results show that the deviation is sizable. For $\\lambda_{\\Phi{S}}=1$ (see text for the parameter definition), the deviation $\\delta_{hhh}^{(1)}$ can be $40\\%$. For $\\lambda_{\\Phi{S}}=1.5$, the $\\delta_{hhh}^{(1)}$ can reach $140\\%$. The si...

  14. One-loop corrections to the Higgs self-couplings in the singlet extension

    Science.gov (United States)

    Kanemura, Shinya; Kikuchi, Mariko; Yagyu, Kei

    2017-04-01

    We investigate predictions on the triple Higgs boson couplings with radiative corrections in the model with an additional real singlet scalar field. In this model, the second physical scalar state (H) appears in addition to the Higgs boson (h) with the mass 125 GeV. The hhh vertex is calculated at the one-loop level, and its possible deviation from the predictions in the standard model is evaluated under various theoretical constraints. The decay rate of H → hh is also computed at the one-loop level. We also take into account the bound from the precise measurement of the W boson mass, which gives the upper limit on the mixing angle α between two physical Higgs bosons for a given value of the mass of H (mH). We find that the deviation in the hhh coupling from the prediction in the standard model can maximally be about 250%, 150% and 75% for mH = 300, 500 and 1000 GeV, respectively, under the requirement that the cutoff scale of the model is higher than 3 TeV. We also discuss deviations from the standard model prediction in double Higgs boson production from the gluon fusion at the LHC using the one-loop corrected Higgs boson vertices.

  15. 中国不同地区科技示范县大豆单产及产量相关性状的比较%Comparison of Soybean Yield and Yield-related Traits of Agri-technology Demonstration Counties in Different Regions of China

    Institute of Scientific and Technical Information of China (English)

    杨如萍; 宋雯雯; 孙石; 吴存祥; 王化俊; 韩天富; 国家大豆产业技术体系综合试验站

    2012-01-01

    分别于2010和2011年对全国18和20个省(区)的130和141个大豆科技示范县进行抽样调查,收集当地大豆生产田的单产及其相关性状数据.在此基础上,按大豆栽培区划进行分区统计,并采用多元逐步回归方法判断不同地区影响产量的关键因素.结果表明,各地区大豆的播种期因耕作制度不同和气象条件多样而存在很大差异,变化幅度大小依次为南方>西北>东北>黄淮海;东北地区大豆种植密度最高,西北、黄淮海居中,南方最低.平均单产高低依次为西北>东北>黄淮海>南方.在农艺和产量性状中,株高以东北大豆为最高,其后依次为西北、黄淮海和南方;单株荚数与单株粒数2个性状的地域差异趋势一致,2010年均依次为南方>西北>黄淮海>东北,2011年均依次为西北>南方>黄淮海>东北;黄淮海地区大豆的百粒重最高,西北次之,东北及南方则相对偏低.多元逐步回归结果表明,在东北和南方地区,影响大豆产量的首要因素为单株粒数,而在西北及黄淮海地区则为单位面积株数.文中讨论了不同主产区提高大豆单产的主攻方向.%The on-site sample survey of 130 and 141 agri-technology demonstration counties in 18 and 20 provinces(autonomous regions) of China was conducted in 2010 and 2011 , respectively. After the survey, the key yield limiting factors in different production regions were determined with step-wise multiple regression analysis. The results showed that soybean sowing dates were consistent with cultivation conditions and farming system in different regions. The order of the sowing date span was South ( biggest) , Northwest, Northeast and Huang-Huai-Hai( HHH,smallest) region;The plant density was the highest in Northeast, middle in Northwest and HHH regions,and the lowest in South China. Soybean yield was the highest in Northwest, the second in the Northeast, the third in HHH and the lowest in the

  16. Study about composite dyeing of natural dyes%植物染料复合染色的若干问题

    Institute of Scientific and Technical Information of China (English)

    罗勇; 王璐; 贾舜华; 张新龙; 周启澄; 胡晓峰; 赵国瑛

    2009-01-01

    为丰富植物染料的色谱,应用DL-CT蓝色植物染料和HHH-CT黄色植物染料对羊毛织物进行复合染色,研究了复合染色在植物染料上的应用.对DL-CT蓝色植物染料和HHH-CT黄色植物染料复合染色的基本原理和工艺技术进行了探讨.分析了染料用量、媒染剂用量等工艺参数对羊毛织物色泽的影响,并通过正交试验优化了工艺;还对还原性植物染料DL-CT新型染色方法进行了探讨.结果表明:DL-CT蓝色植物染料和HHH-CT黄色植物染料通过复合染色可以得到不同的染色色泽,为丰富植物染料的色谱提供了新的途径.

  17. Influence of anomalous VVH and VVHH on determination of Higgs self couplings at ILC

    CERN Document Server

    Kumar, Satendra

    2014-01-01

    The recent discovery of a Higgs boson at LHC, while establishing the Higgs mechanism as the way of electroweak symmetry breaking, started an era of precision measurements involving the Higgs boson. In an effective Lagrangian framework, we consider the e+e- --> ZHH process, at an ILC running at a centre of mass energy of 800 GeV to investigate the effect of the ZZH and ZZHH couplings on the sensitivity of HHH coupling on this process. Our results show that the sensitivity of the trilinear Higgs self couplings on this process has somewhat strong dependence on the Higgs-gauge boson couplings. Single and two parameter reach of ILC with integrated luminosity of 1000 /fb are obtained on the effective couplings, c6 and cH, which are related to the HHH couplings, indicating how these limits are affected by the presence of anomalous ZZH and ZZHH couplings. The kinematic distributions studied to understand the effect of the anomalous couplings, again, show strong influence of Z-H couplings on the dependence of these di...

  18. ANALYSIS ON THE DEVELOPMENT OF CIRCULAR AGRICULTURE IN HUANG- HAI REGION%黄淮海区域循环农业发展的认识与思考

    Institute of Scientific and Technical Information of China (English)

    郭洪海; 宫志远

    2011-01-01

    Huang - Huai - Hai (HHH) is an important agricultural production region. With regional economic and social development, the utilization of wastes such as the crop straw and livestock manure has been the import topic for the regional sustainable agricultural development. Focusing on the principle of" 4R" advocated by circular agriculture, this paper put forward the spatial scale of circular agriculture development with the" three - in - one" pattern of farm - farmer - countryside, which based on farm, farmer and countryside recycling. The organization form of the development circular agriculture should take the government as the main body, pull farmers, joint cooperative economic organization and guide the agricultural leading enterprises to join. Next 5 - 10 years, the development of the circular agriculture in HHH region should take the circular utilization as the predominant mode which include returning the whole straw into field, using the straw for mushroom and livestock, and also innovate corresponding technologies for comprehensively utilization of agricultural wastes in HHH region.%黄淮海区域是我国重要的农产品生产基地.随着区域经济与社会发展,农作物秸秆和畜禽粪便等大量废弃物的综合利用已成为国家及区域农业可持续发展的重要议题.该文紧紧围绕循环农业所倡导的"4R"原则,提出了以农田循环为基础,链接农户循环,铸造农村循环,构建农田-农户-农村"三位一体"的循环农业发展的空间尺度;循环农业的组织形式应以政府为主体,拉动农户,联动合作经济组织,引导农业龙头企业参与;黄淮海区域未来5~10年循环农业的发展应以秸秆原位全量还田循环利用、秸秆菌业循环利用生产和秸秆养畜循环利用生产等为主导模式,并研发创新相应的接口技术,以期建立黄淮海区域农业废弃物高效利用的循环农业生产模式和体系.

  19. Probing anomalous couplings using di-Higgs production in electron–proton collisions

    Directory of Open Access Journals (Sweden)

    Mukesh Kumar

    2017-01-01

    Full Text Available A proposed high energy Future Circular Hadron-Electron Collider would provide sufficient energy in a clean environment to probe di-Higgs production. Using this channel we show that the azimuthal angle correlation between the missing transverse energy and the forward jet is a very good probe for the non-standard hhh and hhWW couplings. We give the exclusion limits on these couplings as a function of integrated luminosity at a 95% C.L. using the fiducial cross sections. With appropriate error fitting methodology we find that the Higgs boson self coupling could be measured to be ghhh(1=1.00−0.17(0.12+0.24(0.14 of its expected Standard Model value at s=3.5(5.0 TeV for an ultimate 10 ab−1 of integrated luminosity.

  20. AcEST: BP916422 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 31 2.5 sp|P22807|SLOU_DROME Homeobox protein slou OS=Drosophila melanog... 30 3.3 sp|A4ZNR4|NKD2_DANRE Protein naked...rotei... 29 9.6 sp|Q1ZXC2|PABPA_DICDI Polyadenylate-binding protein 1-A OS=Dicty... 29 9.6 sp|Q9VVV9|NKD_DROME Protein naked...S 12 SSS P P S Sbjct: 244 SSSSTAPPSPATSPLS 259 >sp|A4ZNR4|NKD2_DANRE Protein naked cuticle homolog 2 OS=Dani...TH +H +H+H +P HH+H + Sbjct: 32 SVATQPPQSQIPPQPQYQYQMAPPPQTHHVHPHHVHPHHQQHPGYVPSHHHHHQ 85 >sp|Q9VVV9|NKD_DROME Protein naked

  1. Probing anomalous couplings using di-Higgs production in electron-proton collisions

    Science.gov (United States)

    Kumar, Mukesh; Ruan, Xifeng; Islam, Rashidul; Cornell, Alan S.; Klein, Max; Klein, Uta; Mellado, Bruce

    2017-01-01

    A proposed high energy Future Circular Hadron-Electron Collider would provide sufficient energy in a clean environment to probe di-Higgs production. Using this channel we show that the azimuthal angle correlation between the missing transverse energy and the forward jet is a very good probe for the non-standard hhh and hhWW couplings. We give the exclusion limits on these couplings as a function of integrated luminosity at a 95% C.L. using the fiducial cross sections. With appropriate error fitting methodology we find that the Higgs boson self coupling could be measured to be ghhh(1) = 1.00-0.17(0.12)+0.24(0.14) of its expected Standard Model value at √{ s} = 3.5 (5.0) TeV for an ultimate 10 ab-1 of integrated luminosity.

  2. CARE07 Coordinated Accelerator Research in Europe

    CERN Multimedia

    2007-01-01

    Annual Meeting, at CERN, 29-31 October 2007 The CARE project started on 1st January 2004 and will end on 31st December 2008. At the end of each year, the progress and status of its activities are reported in a general meeting. This year, the meeting is taking place at CERN. The CARE objective is to generate structured and integrated European cooperation in the field of accelerator research and related R&D. The programme includes the most advanced scientific and technological developments, relevant to accelerator research for particle physics. It is articulated around three Networking Activities and four Joint Activities. The Networking Activities ELAN, BENE and HHH aim to better coordinate R&D efforts at the European level and to strengthen Europe’s ability to produce intense and high-energy particle beams (electrons and positrons, muons and neutrinos, protons and ions, respectively). The Joint Activities, SRF, PHIN, HIPPI and NED, aim at technical developments ...

  3. CARE07 Coordinated Accelerator Research in Europe

    CERN Multimedia

    2007-01-01

    Annual Meeting, at CERN, 29-31 October 2007 The CARE project started on 1st January 2004 and will end on 31st December 2008. At the end of each year, the progress and status of its activities are reported in a general meeting. This year, the meeting takes place at CERN. The CARE objective is to generate structured and integrated European cooperation in the field of accelerator research and related R&D. The programme includes the most advanced scientific and technological developments, relevant to accelerator research for particle physics. It is articulated around three Networking Activities and four Joint Activities. The Networking Activities ELAN, BENE and HHH aim to better coordinate R&D efforts at the European level and to strengthen Europe’s ability to produce intense and high-energy particle beams (electrons and positrons, muons and neutrinos, protons and ions, respectively). The Joint Activities, SRF, PHIN, HIPPI and NED, aim at technical developments on s...

  4. Omega Navigation System Course Book. Volume 1.

    Science.gov (United States)

    1994-07-01

    antenna must be about 15 percent taller . Figure 3.4-9 is a photograph of a grounded tower antenna systemn at the La Reuinion iransmittingy station. .3...provides the 0-30613 10-2-92 F Indicatec1 Inertial Craft Position + Navigation " Cora ected System Craft Position Position Indicated + Position Error...o0 o0 la Na % ;6 0i0~~oCOC~ H NNa oil r- corA t Cl~𔃺 A0A 9 co HQL (n oHI- HHH~~~~~~~~~~f ClllNMNllll~Nlll(JCi~llA CliC to w N0000000a000& 0’c", 100

  5. First-order electroweak phase transition powered by additional F-term loop effects in an extended supersymmetric Higgs sector

    CERN Document Server

    Kanemura, Shinya; Shindou, Tetsuo

    2011-01-01

    We investigate the one-loop effect of new charged scalar bosons on the Higgs potential at finite temperatures in the supersymmetric standard model with four Higgs doublet chiral superfields as well as a pair of charged singlet chiral superfields. In this model, the mass of the lightest Higgs boson $h$ is determined only by the D-term in the Higgs potential at the tree-level, while the triple Higgs boson coupling for $hhh$ can receive a significant radiative correction due to nondecoupling one-loop contributions of the additional charged scalar bosons. We find that the same nondecoupling mechanism can also contribute to realize stronger first order electroweak phase transition than that in the minimal supersymmetric standard model, which is definitely required for a successful scenario of electroweak baryogenesis. Therefore, this model can be a new candidate for a model in which the baryon asymmetry of the Universe is explained at the electroweak scale.

  6. Measuring the 2HDM Scalar Potential at LHC14

    CERN Document Server

    Barger, Vernon; Jackson, Chris B; Peterson, Andrea D; Shaughnessy, Gabe

    2014-01-01

    After the extraordinary discovery of the Higgs boson at the LHC, the next goal is to pin down its underlying dynamics by measuring the Higgs self-couplings, along with its couplings to gauge and matter particles. As a prototype model of new physics in the scalar sector, we consider the Two Higgs Doublet Model (2HDM) with CP-conservation, and evaluate the prospects for measuring the trilinear scalar couplings among the CP-even Higgs bosons $h$ and $H$ ($\\lambda^{hhh}$, $\\lambda^{hhH}$, $\\lambda^{hHH}$) at LHC14. The continuum and resonant production of CP-even Higgs boson pairs, $hh$ and $hH$, offer complementary probes of the scalar potential away from the light-Higgs decoupling limit. We identify the viable search channels at LHC14 and estimate their expected discovery sensitivities.

  7. On the global stability of the wave-map equation in Kerr spaces with small angular momentum

    CERN Document Server

    Ionescu, A D

    2014-01-01

    This paper is motivated by the problem of the nonlinear stability of the Kerr solution for axially symmetric perturbations. We consider a model problem concerning the axially symmetric perturbations of a wave map $\\Phi$ defined from a fixed Kerr solution $\\KK(M,a)$, $0\\le a < M $, with values in the two dimensional hyperbolic space $\\HHH^2$. A particular such wave map is given by the complex Ernst potential associated to the axial Killing vectorfield $\\Z$ of $\\KK(M,a)$. We conjecture that this stationary solution is stable, under small axially symmetric perturbations, in the domain of outer communication (DOC) of $\\KK(M,a)$, for all $0\\le a

  8. Workshop on Accelerator Magnet Superconductors, Design and Optimization

    CERN Document Server

    WAMSDO Workshop

    2009-01-01

    This report contains the proceedings of the CARE-HHH-AMT Workshop on Accelerator Magnet Superconductors, Design and Optimization (WAMSDO) held at CERN from 19 to 23 May 2008. The needs in terms of superconducting magnets for the accelerator projects were discussed, mainly for the LHC interaction regions and injector upgrades, and for the GSI FAIR complex. The first part of the workshop focused on the development of superconductor and cables, i.e., low-loss Nb-Ti cables, Nb3Sn and high-temperature superconductors. An industry session summarized the actual plans and status of the activities in the main European industries. Then, a worldwide status of the high field magnets programme was presented. A special session was devoted to fast cycled magnets, including FAIR facilities and LHC injector upgrades. A final session focused on the optimization methods and numerical tools for magnet design.

  9. Phenomenological Models of Holographic Superconductors and Hall currents

    CERN Document Server

    Aprile, Francesco; Rodriguez-Gomez, Diego; Russo, Jorge G

    2010-01-01

    We study general models of holographic superconductivity parametrized by four arbitrary functions of a neutral scalar field of the bulk theory. The models can accommodate several features of real superconductors, like arbitrary critical temperatures and critical exponents in a certain range, and perhaps impurities, boundary or thickness effects. We find analytical expressions for the critical exponents of the general model and show that they satisfy the Rushbrooke identity. An important subclass of models exhibits second order phase transitions. A study of the specific heat shows that general models can also describe holographic superconductors undergoing first, second and third (or higher) order phase transitions. We discuss how small deformations of the HHH model lead to the appearance of resonance peaks in the conductivity, which become narrower as the temperature is gradually decreased, without the need for tuning mass of the scalar to be close to the Breitenlohner-Freedman bound. Finally, we investigate ...

  10. Scenarios for sLHC and vLHC

    CERN Document Server

    Scandale, Walter

    2008-01-01

    The projected lifetime of the LHC low-beta quadrupoles and evolution of the statistical error halving time call for an LHC luminosity upgrade by the middle of the coming decade. In the framework of the EU CARE-HHH network, two scenarios have been developed for increasing the LHC peak luminosity by a factor 10, to 1035 cm−2s−1 (“sLHC”). Both scenarios imply a rebuilding of the high-luminosity interaction regions (IRs) in combination with a consistent change of beam parameters. However, their respective features, bunch structures, IR layouts, merits and challenges differ substantially. In either scenario luminosity leveling during a store would be advantageous for the physics experiments. Longer-term R&D efforts are devoted to a higher-energy hadron collider (“vLHC”), which could be realized on a green field or as a later and more radical LHC upgrade.

  11. Searching Heavier Higgs Boson via $H \\to hh \\to WW^*\\gamma\\gamma$ at LHC Run-2

    CERN Document Server

    Lü, Lan-Chun; Fang, Yaquan; He, Hong-Jian; Zhang, Huijun

    2015-01-01

    The LHC discovery of a light Higgs particle $h^0$ (125GeV) opens up new prospect for searching heavier Higgs boson(s) at the LHC Run-2, which will unambiguously point to new physics beyond the standard model (SM). We study the detection of a heavier neutral Higgs boson $H^0$ via di-Higgs production channel at the LHC (14TeV), $H^0 \\to h^0h^0 \\to WW^*\\gamma\\gamma$. This directly probes the $Hhh$ cubic Higgs interaction, which exists in most extensions of the SM Higgs sector. For the decay products of final states $WW^*$, we include both pure leptonic mode $WW^* \\to \\ell\\bar{\

  12. Decoupling Property of SUSY Extended Higgs Sectors and Implication for Electroweak Baryogenesis

    CERN Document Server

    Kanemura, Shinya; Shindou, Tetsuo

    2012-01-01

    One-loop contributions to the Higgs potential at finite temperatures are discussed in the supersymmetric standard model with four Higgs doublet chiral superfields as well as a pair of charged singlet chiral superfields. The mass of the lightest Higgs boson $h$ is determined only by the D-term at the tree-level in this model, while the triple Higgs boson coupling for $hhh$ can receive a significant radiative correction. The same nondecoupling effect can also contribute to realize the sufficient first order electroweak phase transition, which is required for a successful scenario of electroweak baryogenesis. This model can be a new candidate for a model in which the baryon asymmetry of the Universe is explained at the electroweak scale. We also discuss the implication for the measurement of the triple Higgs boson coupling at the ILC.

  13. Production of Light Higgs Pairs in 2-Higgs Doublet Models via the Higgs-strahlung Process at the LHC

    CERN Document Server

    Moretti, M; Piccinini, F; Pittau, R; Rathsman, J

    2010-01-01

    At the Large Hadron Collider, we prove the feasibility to detect pair production of the lightest CP-even Higgs boson h of a Type II 2-Higgs Doublet Model through the process q \\bar q' --> Vhh (Higgs-strahlung, V=W+-,Z), in presence of two h --> b \\bar b decays. We also show that, through such production and decay channels, one has direct access to the following Higgs self-couplings, thus enabling one to distinguish between a standard and the Supersymmetric version of the above model: lambda_(Hhh) -- which constrains the form of the Higgs potential -- as well as lambda_(W+- H+- h) and lambda_(Z A h) -- which are required by gauge invariance. Unfortunately, such claims cannot be extended to the Minimal Supersymmetric Standard Model, where the extraction of the same signals is impossible.

  14. Probing anomalous couplings using di-Higgs production in electron-proton collisions

    CERN Document Server

    Kumar, Mukesh; Islam, Rashidul; Cornell, Alan S; Klein, Max; Klein, Uta; Mellado, Bruce

    2015-01-01

    A proposed high energy Future Circular Hadron-Electron Collider would provide sufficient energy in a clean environment to probe di-Higgs production. Using this channel we show that the azimuthal angle correlation between the missing transverse energy and the forward jet is a very good probe for the non-standard $hhh$ and $hhWW$ couplings. We give the exclusion limits on these couplings as a function of integrated luminosity at 95\\% C.L. using the fiducial cross sections. The Higgs self-coupling could be measured to be within factors of $0.84 \\, (0.89) < \\gonehhh < 1.19 \\, (1.12)$ of its expected Standard Model value at $\\sqrt{s} = 3.5 \\,(5.0)$ TeV for an ultimate 10 $\\abinv$ of integrated luminosity.

  15. GIS-measured walkability, transit, and recreation environments in relation to older Adults' physical activity: A latent profile analysis.

    Science.gov (United States)

    Todd, Michael; Adams, Marc A; Kurka, Jonathan; Conway, Terry L; Cain, Kelli L; Buman, Matthew P; Frank, Lawrence D; Sallis, James F; King, Abby C

    2016-12-01

    An infrequently studied question is how diverse combinations of built environment (BE) features relate to physical activity (PA) for older adults. We derived patterns of geographic information systems- (GIS) measured BE features and explored how they accounted for differences in objective and self-reported PA, sedentary time, and BMI in a sample of older adults. Senior Neighborhood Quality of Life Study participants (N=714, aged 66-97years, 52.1% women, 29.7% racial/ethnic minority) were sampled in 2005-2008 from the Seattle-King County, WA and Baltimore, MD-Washington, DC regions. Participants' home addresses were geocoded, and net residential density, land use mix, retail floor area ratio, intersection density, public transit density, and public park and private recreation facility density measures for 1-km network buffers were derived. Latent profile analyses (LPAs) were estimated from these GIS-based measures. In multilevel regression models, profiles were compared on accelerometer-measured moderate-to-vigorous PA (MVPA) and sedentary time and self-reported PA, adjusting for covariates and clustering. Analyses were conducted in 2014-2015. LPAs yielded three profiles: low walkability/transit/recreation (L-L-L); mean walkability/transit/recreation (M-M-M); and high walkability/transit/recreation (H-H-H). Three PA outcomes were more favorable in the HHH than the LLL profile group (difference of 7.2min/day for MVPA, 97.8min/week for walking for errands, and 79.2min/week for walking for exercise; all ps<0.02). The most and least activity-supportive BE profiles showed greater differences in older adults' PA than did groupings based solely on a 4-component walkability index, suggesting that diverse BE features are important for healthy aging. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. One-loop radiative correction to the triple Higgs coupling in the Higgs singlet model

    Science.gov (United States)

    He, Shi-Ping; Zhu, Shou-hua

    2017-01-01

    Though the 125 GeV Higgs boson is consistent with the standard model (SM) prediction until now, the triple Higgs coupling can deviate from the SM value in the physics beyond the SM (BSM). In this paper, the radiative correction to the triple Higgs coupling is calculated in the minimal extension of the SM by adding a real gauge singlet scalar. In this model there are two scalars h and H and both of them are mixing states of the doublet and singlet. Provided that the mixing angle is set to be zero, namely the SM limit, h is the pure left-over of the doublet and its behavior is the same as that of the SM at the tree level. However the loop corrections can alter h-related couplings. In this SM limit case, the effect of the singlet H may show up in the h-related couplings, especially the triple h coupling. Our numerical results show that the deviation is sizable. For λΦS = 1 (see text for the parameter definition), the deviation δhhh(1) can be 40%. For λΦS = 1.5, the δhhh(1) can reach 140%. The sizable radiative correction is mainly caused by three reasons: the magnitude of the coupling λΦS, light mass of the additional scalar and the threshold enhancement. The radiative corrections for the hVV, hff couplings are from the counter-terms, which are the universal correction in this model and always at O(1%). The hZZ coupling, which can be precisely measured, may be a complementarity to the triple h coupling to search for the BSM. In the optimal case, the triple h coupling is very sensitive to the BSM physics, and this model can be tested at future high luminosity hadron colliders and electron-positron colliders.

  17. Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans.

    Science.gov (United States)

    Moe, Elin; Hall, David R; Leiros, Ingar; Monsen, Vivi Talstad; Timmins, Joanna; McSweeney, Sean

    2012-06-01

    3-Methyladenine DNA glycosylase II (AlkA) is a DNA-repair enzyme that removes alkylated bases in DNA via the base-excision repair (BER) pathway. The enzyme belongs to the helix-hairpin-helix (HhH) superfamily of DNA glycosylases and possesses broad substrate specificity. In the genome of Deinococcus radiodurans, two genes encoding putative AlkA have been identified (Dr_2074 and Dr_2584). Dr_2074 is a homologue of human AlkA (MPG or AAG) and Dr_2584 is a homologue of bacterial AlkAs. Here, the three-dimensional structure of Dr_2584 (DrAlkA2) is presented and compared with the previously determined structure of Escherichia coli AlkA (EcAlkA). The results show that the enzyme consists of two helical-bundle domains separated by a wide DNA-binding cleft and contains an HhH motif. Overall, the protein fold is similar to the two helical-bundle domains of EcAlkA, while the third N-terminal mixed α/β domain observed in EcAlkA is absent. Substrate-specificity analyses show that DrAlkA2, like EcAlkA, is able to remove both 3-methyladenine (3meA) and 7-methylguanine (7meG) from DNA; however, the enzyme possesses no activity towards 1,N(6)-ethenoadenine (ℇA) and hypoxanthine (Hx). In addition, it shows activity towards the AlkB dioxygenase substrates 3-methylcytosine (3meC) and 1-methyladenine (1meA). Thus, the enzyme seems to preferentially repair methylated bases with weakened N-glycosidic bonds; this is an unusual specificity for a bacterial AlkA protein and is probably dictated by a combination of the wide DNA-binding cleft and a highly accessible specificity pocket.

  18. 近20年黄淮海地区气候变暖对夏玉米生育进程及产量的影响%Effects of Climate Warming on Growth Process and Yield of Summer Maize in Huang-Huai-Hai Plain in Last 20 Years

    Institute of Scientific and Technical Information of China (English)

    陆伟婷; 于欢; 曹胜男; 陈长青

    2015-01-01

    东、安徽与江苏夏玉米产量将会下降;整个黄淮海地区,当GDD30上升时,会造成全地区夏玉米产量下降,且山东下降最为明显。【结论】黄淮海地区夏玉米的实际生产受气候变暖的影响,夏玉米对气候变暖是逐步适应,可以利用其适应潜力,通过选育生育期长和耐热的夏玉米品种和改进栽培措施来适应气候变暖,从而提高夏玉米产量。%[Objective]The impacts of climate warming on growth process and yield of summer maize in recent 20 years in Huang-Huai-Hai Plain (HHH) of China, for the purpose of providing a theoretical basis for food security.[Method]Six provinces and regions (Hebei, Henan, Shandong, Anhui and Jiangsu provinces and Beijing-Tianjin region) in HHH Plain were selected as the area for conducting research. Making use of the meteorological observation data and the long-term observation data of summer maize in recent 20 years in HHH Plain, the relationships between climatic factors (temperature and precipitation) and growth process and historical production data during growing season were systematically studied by correlation and nonlinear multiple regression analysis and other statistical methods.[Result]In recent twenty years, an upward trend was found out in the temperature during the growth season of summer maize in Huang-Huai-Hai Plain. The precipitation in northern regions, Beijing-Tianjin region, Hebei and Shandong provinces, was reduced, while it was increased in Henan, Anhui and Jiangsu provinces. Compared to 1990s, the growth process of summer maize in HHH Plain was significantly changed since 2000. The whole growth stages were prolonged with vegetative period shortened by 2 and 1 d in Hebei and Shandong provinces, prolonged by 1 d in Henan province and reproductive stage prolonged by 4 and 2 d in Hebei and Shandong provinces, Henan province remained the same. Different correlations were found between each growth duration and temperature

  19. Methods for testing automatic mode switching in patients implanted with DDD(R) pacemakers.

    Science.gov (United States)

    Lau, Chu-Pak; Mascia, Franco; Corbucci, Giorgio; Padeletti, Luigi

    2004-01-01

    The assessment of automatic mode switching (AMS) algorithms is impossible in vivo, due to a low chance of seeing the patient at the onset of a spontaneous episode of atrial fibrillation (AF). As the induction of AF to test AMS has clinical concerns, three alternative and non-invasive techniques may be proposed for this purpose: myopotentials, chest wall stimulation, and an external supraventricular arrhythmia simulator. The first method is simple and does not require additional equipment, even though in some patients adequate signals cannot be generated with a soft effort such as handgrip or hand compression. The main advantage of the chest wall stimulation method is the possibility that it be performed in every implanting center, since it is based on the use of standard devices for cardiac stimulation. The method based on the external supraventricular arrhythmia simulator allows the most detailed of the ECG traces, but it needs a dedicated electronic device.

  20. DDD-ICD: discrimination of supraventricular tachyarrhythmias Discriminação de taquiarritmias supraventriculares

    Directory of Open Access Journals (Sweden)

    Amiran R. REVISHVILI

    1999-01-01

    Full Text Available Background: Dual Chamber Implantable Cardioverter Defibrillator (ICD in addition to providing hemodynamically improved bradycardia support can also reduce the incidence of inappropriate ventricular shocks owing to episodes of Supraventricular Tachycardia (SVT, with reported incidence of up to 41% of patients. An atrio-ventricular (AV discrimination algorithm is needed in dual chamber implantable cardioverter-defibrillators (ICD to avoid these inappropriate shocks. Methods: An AV discrimination algorithm, SMART DetectionTM, has been developed to differentiate between episodes of ventricular tachycardia (VT and SVT. It relies on the concept that the chamber with the higher rate is the origin of the tachycardia. The ventricular rate stability criterion is also used to detect concurrent VT during an episode of SVT. Other parameters used in the discrimination algorithm are: atrial and ventricular rhythm multiplicity, P-R regularity, sudden onset. The SMART DetectionTM algorithm has been implemented in the Biotronik Phylax® AV dual chamber ICD. The original SMART DetectionTM has been improved recently with the addition of active detection in the case of 1:1 AV conduction. Results: 10 patients were implanted with Phylax® AV's at the Bakoulev Institute. Analyses of stored dual chamber intracardiac electrogram (IEGM indicate that all episodes of VTs and Ventricular Fibrillations (VF were terminated following appropriate therapies. No episode of Atrial Flutter (Afl or Atrial Fibrillation (AF was treated even though the majority of patients have a history of SVTs. In one patient, an episode of Sinus Tachycardia (ST was inappropriately treated. Increasing the sudden onset criterion, which is used only in the case of stable 1:1 rhythms, was sufficient to prevent recurrence of inappropriate therapy. To avoid the necessity of setting the, not very reliable, sudden onset criterion an active detection procedure was developed. Isolated Premature Ventricular Stimuli were used to test the hypothesis of VT with retrograde atrial conduction in the 1:1 AV rate case. Results of acute tests of this active detection improvement are reported in this paper. Conclusion: The SMART DetectionTM algorithm, with is active detection improvement in the case of 1:1 AV rate, should prove to be an effective AV discrimination algorithm in dual chamber ICD which will offer freedom from unnecessary shocks in response to SVTs.Introdução: Cardioversores-desfibriladores implantáveis (CDI de câmara dupla, além de garantirem um suporte hemodinâmico de bradicardia mais eficaz, também reduzem a incidência de choque ventricular inadequado devido a episódios de taquicardia supraventricular (TSV, cuja incidência na literatura é de até 41% de pacientes. Um algoritmo atrioventricular (AV discriminatório faz-se necessário em um CDI de câmara dupla, a fim de evitar estes choques inadequados. Metodologia: Um algoritmo AV discriminatório, o SMART Detection®, foi desenvolvido para diferenciação entre os episódios de taquicardia ventricular (TV e TVS. Seu mecanismo baseia-se no fato de que a câmara com índice mais alto é a de origem da taquicardia. O critério de razão de estabilidade ventricular é usado também para detectar TV simultânea a um episódio de TSV. Outros parâmetros usados no algoritmo discriminatório são: multiplicidade rítmica atrial e ventricular, regularidade P-R, início repentino. O algoritmo SMART Detection® foi implementado no Biotronik Phylax® CDI AV de duas câmaras. O SMART Detection® original foi aperfeiçoado recentemente com o acréscimo de um detector ativo em caso de condução AV 1:1. Resultados: O Phylax® AV foi implantado em 10 pacientes no Instituto Bakoulev. A avaliação de eletrogramas intracardíacos (EGMI de câmara dupla armazenados indicam que todos os episódios de TVs e fibrilações ventriculares (FV tiveram seu término após terapias adequadas. Nenhum episódio de flutter atrial (FA ou fibrilação atrial (FA fora tratado, apesar dos antecedentes históricos da maioria dos pacientes incluírem TSVs. Um único caso de taquicardia sinusal (TS foi tratado inadequadamente. Ampliando o critério de início repentino, usado somente no caso de ritmos 1:1 estáveis, fora o suficiente para prevenir a repetição de tratamento inadequado. A fim de evitar o uso não muito confiável do critério de início repentino, desenvolveu-se um detector ativo de procedimento. Estímulos ventriculares prematuros isolados foram usados para testar a hipótese de TV com condução atrial retrógrada em casos AV de índice 1:1. Resultados de testes agudos do aperfeiçoamento do detector ativo são relatados neste estudo. Conclusão: O algoritmo SMART Detection®, juntamente com seu aperfeiçoamento de detecção ativo em casos AV de índices 1:1, deve provar ser um algoritmo AV discriminatório eficaz em CDI de câmara dupla, evitando choques desnecessários devido a TSVs.

  1. Numerical Experiment on the Impact of the Urbanizing on Regional Climate and Water Resources in Huanghe-Huaihe-Haihe Zone%大规模城镇化对黄淮海地区气候及水资源影响的数值试验

    Institute of Scientific and Technical Information of China (English)

    陈怀亮; 徐祥德; 李飞; 王兰宁; 杜子璇

    2012-01-01

    Numerical experiment has been carried out over HHH (Huanghe-Huaihe-Haihe) zone by using regional climate model RegCM3 for 5 years (2001-2005). The simulation has two tests, a control test and a sensitivity test on urbanizing conditions. The output results of the regional climate model are precipitation, evaporation, temperature, humidity, soil moisture, runoff, and the total water vapor con-tent. The difference value between sensitivity test and control test responds to the influence of vegetation variation on regional climate and water resources in HHH zone. The results showed that the urbanization could weaken the local wind field, decrease rainfall and water resources and make the temperature in-crease. The variations resulting in the autumn drought happen easily, the floods became more severity be- cause of the increasing of runoff in summer. The urbanization caused the decreasing of soil moisture holding capaci- ty, and stimulated the vegetation degradation greatly. Accordingly, the climate abnormity and the shortening ofwater resources in HHH zone transformed tempestuously, and led to the ecological environment deteriorating.%黄淮海地区是我国传统的农耕区,也是经济快速发展、城镇化进程快速推进的区域之一,使得该地区植被覆盖发生了明显变化。为研究城镇化对气候与水资源的影响,应用RegCM3区域气候模式,通过控制试验和敏感性试验,在保证积分时间(2001-2005年)的情况下,输出降水、蒸发、温度、湿度、土壤水分、径流、整层水汽含量等资料,利用敏感性试验和控制试验输出量的差值,来分析黄淮海地区城镇化对气候和水资源要素的影响情况。结果表明,城镇化对研究地区气候及水资源造成的影响主要表现在使局地风场减弱、降水减少、地面气温增加、空气湿度减小、水资源总量减少、土壤含水量减少和地表径流增加等方面,从而对气候和水资源造成影响。

  2. Neutron scattering investigations of frustated magnets

    Science.gov (United States)

    Fennell, Tom

    This thesis describes the experimental investigation of frustrated magnetic systems based on the pyrochlore lattice of corner-sharing tetrahedra. Ho2Ti207 and Dy2Ti207 are examples of spin ices, in which the manifold of disordered magnetic groundstates maps onto that of the proton positions in ice. Using single crystal neutron scattering to measure Bragg and diffuse scattering, the effect of applying magnetic fields along different directions in the crystal was investigated. Different schemes of degeneracy removal were observed for different directions. Long and short range order, and the coexistence of both could be observed by this technique.The field and temperature dependence of magnetic ordering was studied in Ho2Ti207 and Dy2Ti207. Ho2Ti2()7 has been more extensively investigated. The field was applied on [00l], [hh0], [hhh] and [hh2h]. Dy2Ti207 was studied with the field applied on [00l] and [hho] but more detailed information about the evolution of the scattering pattern across a large area of reciprocal space was obtained.With the field applied on [00l] both materials showed complete degeneracy removal. A long range ordered structure was formed. Any magnetic diffuse scattering vanished and was entirely replaced by strong magnetic Bragg scattering. At T =0.05 K both materials show unusual magnetization curves, with a prominent step and hysteresis. This was attributed to the extremely slow dynamics of spin ice materials at this temperature.Both materials were studied in greatest detail with the field applied on [hh0]. The coexistence of long and short range order was observed when the field was raised at T = 0.05 K. The application of a field in this direction separated the spin system into two populations. One could be ordered by the field, and one remained disordered. However, via spin-spin interactions, the field restricted the degeneracy of the disordered spin population. The neutron scattering pattern of Dy2Ti207 shows that the spin system was separated

  3. A new direct absorption measurement for high precision and accurate measurement of water vapor in the UT/LS

    Science.gov (United States)

    Sargent, M. R.; Sayres, D. S.; Smith, J. B.; Anderson, J.

    2011-12-01

    Highly accurate and precise water vapor measurements in the upper troposphere and lower stratosphere are critical to understanding the climate feedbacks of water vapor and clouds in that region. However, the continued disagreement among water vapor measurements (~1 - 2 ppmv) are too large to constrain the role of different hydration and dehydration mechanisms operating in the UT/LS, with model validation dependent upon which dataset is chosen. In response to these issues, we present a new instrument for measurement of water vapor in the UT/LS that was flown during the April 2011 MACPEX mission out of Houston, TX. The dual axis instrument combines the heritage and validated accuracy of the Harvard Lyman-alpha instrument with a newly designed direct IR absorption instrument, the Harvard Herriott Hygrometer (HHH). The Lyman-alpha detection axis has flown aboard NASA's WB-57 and ER2 aircraft since 1994, and provides a requisite link between the new HHH instrument and the long history of Harvard water vapor measurements. The instrument utilizes the highly sensitive Lyman-alpha photo-fragment fluorescence detection method; its accuracy has been demonstrated though rigorous laboratory calibrations and in situ diagnostic procedures. The Harvard Herriott Hygrometer employs a fiber coupled near-IR laser with state-of-the-art electronics to measure water vapor via direct absorption in a spherical Herriott cell of 10 cm length. The instrument demonstrated in-flight precision of 0.1 ppmv (1-sec, 1-sigma) at mixing ratios as low as 5 ppmv with accuracies of 10% based on careful laboratory calibrations and in-flight performance. We present a description of the measurement technique along with our methodology for calibration and details of the measurement uncertainties. The simultaneous utilization of radically different measurement techniques in a single duct in the new Harvard Water Vapor (HWV) instrument allows for the constraint of systematic errors inherent in each technique

  4. Genotype data: 11 [

    Lifescience Database Archive (English)

    Full Text Available T28 BDDBBBDDDD-BDDBBBDDDBDDDDDDDBBDBBDDDDDBDDDBDBDDDDDDBDDDDDDDDDDDBDBBDBDBBDB-DBDDDDBBBBDDDDBBDDDBDBBDD...DDD-BDDDDDBDBDDDDDDBDDDBDDDBDDDDDDBDD--BDBB-DDDDD-BDBBDDDDDDDDDBDD-DDD-DDBDBDDDDDBDBBD ...

  5. CARE05 coordinated accelerator research in Europe

    CERN Multimedia

    2005-01-01

    Annual Meeting at CERN, 23-25 November 2005 CARE started on 1st January 2004 and will last for five years. At the end of each year it holds a general meeting to report on the progress and status of its activities. This year, the CARE annual meeting is taking place at CERN The objective of the CARE project is to generate structured and integrated European cooperation in the field of accelerator research and related R&D. The program includes the most advanced scientific and technological developments, relevant to accelerator research for Particle Physics. It is articulated around three Networking Activities and four Joint Activities. The Networking Activities ELAN, BENE and HHH aim to better coordinate R&D efforts at the European level and to strengthen Europe's ability to evaluate and develop methods of producing intense and high energy beams of electrons, protons, muons and neutrinos. These activities are embedded in world-wide efforts towards future e+e- linear colliders, superior neutrino beam fa...

  6. Special structures and properties of hydrogen nanowire confined in a single walled carbon nanotube at extreme high pressure

    Directory of Open Access Journals (Sweden)

    Yueyuan Xia

    2012-06-01

    Full Text Available Extensive ab initio molecular dynamics simulations indicate that hydrogen can be confined in single walled carbon nanotubes to form high density and high pressure H2 molecular lattice, which has peculiar shell and axial structures depending on the density or pressure. The band gap of the confined H2 lattice is sensitive to the pressure. Heating the system at 2000K, the H2 lattice is firstly melted to form H2 molecular liquid, and then some of the H2 molecules dissociate accompanied by drastic molecular and atomic reactions, which have essential effect on the electronic structure of the hydrogen system. The liquid hydrogen system at 2000K is found to be a particular mixed liquid, which consists of H2 molecules, H atoms, and H-H-H trimers. The dissociated H atoms and the trimers in the liquid contribute resonance electron states at the Fermi energy to change the material properties substantially. Rapidly cooling the system from 2000K to 0.01 K, the mixed liquid is frozen to form a mixed solid melt with a clear trend of band gap closure. It indicates that this solid melt may become a superconducting nanowire when it is further compressed.

  7. HD/H2 as a probe of the roles of gas, dust, light, metallicity and cosmic rays in promoting the growth of molecular hydrogen in the diffuse interstellar medium

    CERN Document Server

    Liszt, H S

    2014-01-01

    We modelled recent observations of UV absorption of HD and \\HH\\ in the Milky Way and toward damped/sub-damped Lyman alpha systems at z=0.18 and z $>$ 1.7. N(HD)/N(\\HH) ratios reflect the separate self-shieldings of HD and \\HH\\ and the coupling introduced by deuteration chemistry. Locally, observations are explained by diffuse molecular gas with $ 16 \\pccc \\la$ n(H) $\\la 128 \\pccc $ if the cosmic-ray ionization rate per H-nucleus \\zetaH $= 2\\times 10^{-16}\\ps$ as inferred from \\H3\\p\\ and OH\\p. The dominant influence on N(HD)/N(\\HH) is the cosmic-ray ionization rate with a much weaker downward dependence on n(H) at Solar metallicity, but dust-extinction can drive N(HD) higher as with N(\\HH). At z $>$ 1.7, N(HD) is comparable to the Galaxy but with 10x smaller N(\\HH) and somewhat smaller N(\\HH)/N(H I). Comparison of our Galaxy and the Magellanic Clouds shows that smaller \\HH/H is expected at sub-Solar metallicity and we show by modelling that HD/\\HH\\ increases with density at low metallicity, opposite to the Mil...

  8. Calculations of multi-particle processes at the one-loop level: precise predictions for the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Karg, Stefan

    2007-07-01

    We present a calculation of the loop-induced processes gg{yields}HH and gg{yields}HHH, and investigate the observability of multi-Higgs boson production at the LHC in the Standard Model and beyond. While the SM cross sections are too small to allow observation at the LHC, we demonstrate that physics beyond the SM can lead to amplified, observable cross sections. Furthermore, the applicability of the heavy top quark approximation in two- and three-Higgs boson production is investigated. The calculation of the process PP{yields}VV+jet at NLO is an important background process to Higgs production in association with a jet at the LHC. We compute the virtual corrections to this process which form the ''bottleneck'' for obtaining a complete NLO prediction. The resulting analytic expressions are generated with highly automated computer routines and translated into a flexible Fortran code, which can be employed in the computation of differential cross sections of phenomenological interest. (orig.)

  9. Radiative corrections to the Higgs couplings in the triplet model

    CERN Document Server

    Kikuchi, Mariko

    2013-01-01

    The feature of extended Higgs models can appear in the pattern of deviations from the Standard Model (SM) predictions in coupling constants of the SM-like Higgs boson ($h$). We can thus discriminate extended Higgs models by precisely measuring the pattern of deviations in the coupling constants of $h$, even when extra bosons are not found directly. In order to compare the theoretical predictions to the future precision data at the ILC, we must evaluate the theoretical predictions with radiative corrections in various extended Higgs models. In this talk, we give our comprehensive study for radiative corrections to various Higgs boson couplings of $h$ in the minimal Higgs triplet model (HTM). First, we define renormalization conditions in the model, and we calculate the Higgs coupling; $g\\gamma\\gamma, hWW, hZZ$ and $hhh$ at the one loop level. We then evaluate deviations in coupling constants of the SM-like Higgs boson from the predictions in the SM. We find that one-loop contributions to these couplings are su...

  10. Probing triple-Higgs productions via $4b2\\gamma$ at a 100 TeV hadron collider

    CERN Document Server

    Chen, Chien-Yi; Zhao, Xiaoran; Zhong, Yi-Ming; Zhao, Zhijie

    2016-01-01

    The quartic self-coupling of the Standard Model Higgs boson can only be measured by observing the triple-Higgs production process, but it is challenging for the LHC Run 2 or ILC at a few TeV because of its extremely small production rate. In this paper, we present a detailed MC simulation study of the triple-Higgs production through gluon fusion at a 100 TeV hadron collider and explore the feasibility of observing this production mode. We focus on the decay channel $HHH\\rightarrow b\\bar{b}b\\bar{b}\\gamma\\gamma$, investigating detector effects and optimizing the kinematic cuts to discriminate the signal from the backgrounds. Our study shows that in order to observe the Standard Model triple-Higgs signal, the integrated luminosity of a 100 TeV hadron collider should be greater than $1.8\\times 10^4$ ab$^{-1}$. We also explore the dependence of the cross section upon the trilinear ($\\lambda_3$) and quartic ($\\lambda_4$) self-couplings of the Higgs. We find that, through a search in the triple Higgs production, the...

  11. Simulating canopy stomatal conductance of winter wheat and its distribution using remote sensing information

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The canopy stomatal movement, a plant physiological process, generally occurs within leaves but its influence on exchange of CO2, water vapor, and sensible heat fluxes between atmosphere and terrestrial ecosystem. Many studies have documentedthat the interaction between leaf photosynthesis and canopy stomatal conductance is obvious. Thus, information on stomatal conductance is valuable in climate and ecosystem models. In curren study, a newly developed model was adopted to calculate canopy stomatal conductance of winter wheat in Huang-Huai-Hai (H-H-H) Plain of China (31.5-42.7, 110.0-123.0). The remote sensing information from NOAA-AVHRR and meteorological observed data were used to estimate regional scale stomatal conductance distribution. Canopy stomatal conductance distribution pattern of winter wheat onMarch 18, 1997 was also presented. The developed canopy stomatalconductance model might be used to estimate canopy stomatal conductance in land surface schemes and seems can be acted as a boundary condition in regional climatic model runs.

  12. Improved grazing management may increase soil carbon sequestration in temperate steppe.

    Science.gov (United States)

    Chen, Wenqing; Huang, Ding; Liu, Nan; Zhang, Yingjun; Badgery, Warwick B; Wang, Xiaoya; Shen, Yue

    2015-07-03

    Different grazing strategies impact grassland plant production and may also regulate the soil carbon formation. For a site in semiarid temperate steppe, we studied the effect of combinations of rest, high and moderate grazing pressure over three stages of the growing season, on the process involved in soil carbon sequestration. Results show that constant moderate grazing (MMM) exhibited the highest root production and turnover accumulating the most soil carbon. While deferred grazing (RHM and RMH) sequestered less soil carbon compared to MMM, they showed higher standing root mass, maintained a more desirable pasture composition, and had better ability to retain soil N. Constant high grazing pressure (HHH) caused diminished above- and belowground plant production, more soil N losses and an unfavorable microbial environment and had reduced carbon input. Reducing grazing pressure in the last grazing stage (HHM) still had a negative impact on soil carbon. Regression analyses show that adjusting stocking rate to ~5SE/ha with ~40% vegetation utilization rate can get the most carbon accrual. Overall, the soil carbon sequestration in the temperate grassland is affected by the grazing regime that is applied, and grazing can be altered to improve soil carbon sequestration in the temperate steppe.

  13. Ab initio coordination chemistry for nickel chelation motifs.

    Science.gov (United States)

    Sudan, R Jesu Jaya; Kumari, J Lesitha Jeeva; Sudandiradoss, C

    2015-01-01

    Chelation therapy is one of the most appreciated methods in the treatment of metal induced disease predisposition. Coordination chemistry provides a way to understand metal association in biological structures. In this work we have implemented coordination chemistry to study nickel coordination due to its high impact in industrial usage and thereby health consequences. This paper reports the analysis of nickel coordination from a large dataset of nickel bound structures and sequences. Coordination patterns predicted from the structures are reported in terms of donors, chelate length, coordination number, chelate geometry, structural fold and architecture. The analysis revealed histidine as the most favored residue in nickel coordination. The most common chelates identified were histidine based namely HHH, HDH, HEH and HH spaced at specific intervals. Though a maximum coordination number of 8 was observed, the presence of a single protein donor was noted to be mandatory in nickel coordination. The coordination pattern did not reveal any specific fold, nevertheless we report preferable residue spacing for specific structural architecture. In contrast, the analysis of nickel binding proteins from bacterial and archeal species revealed no common coordination patterns. Nickel binding sequence motifs were noted to be organism specific and protein class specific. As a result we identified about 13 signatures derived from 13 classes of nickel binding proteins. The specifications on nickel coordination presented in this paper will prove beneficial for developing better chelation strategies.

  14. Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.

    Science.gov (United States)

    Waisbren, Susan E; Gropman, Andrea L; Batshaw, Mark L

    2016-07-01

    The Urea Cycle Disorders Consortium (UCDC) has conducted, beginning in 2006, a longitudinal study (LS) of eight enzyme deficiencies/transporter defects associated with the urea cycle. These include N-acetylglutamate synthase deficiency (NAGSD); Carbamyl phosphate synthetase 1 deficiency (CPS1D); Ornithine transcarbamylase deficiency (OTCD); Argininosuccinate synthetase deficiency (ASSD) (Citrullinemia); Argininosuccinate lyase deficiency (ASLD) (Argininosuccinic aciduria); Arginase deficiency (ARGD, Argininemia); Hyperornithinemia, hyperammonemia, homocitrullinuria (HHH) syndrome (or mitochondrial ornithine transporter 1 deficiency [ORNT1D]); and Citrullinemia type II (mitochondrial aspartate/glutamate carrier deficiency [CITRIN]). There were 678 UCD patients enrolled in 14 sites in the U.S., Canada, and Europe at the writing of this paper. This review summarizes findings of the consortium related to outcome, focusing primarily on neuroimaging findings and neurocognitive function. Neuroimaging studies in late onset OTCD offered evidence that brain injury caused by biochemical dysregulation may impact functional neuroanatomy serving working memory processes, an important component of executive function and regulation. Additionally, there were alteration in white mater microstructure and functional connectivity at rest. Intellectual deficits in OTCD and other urea cycle disorders (UCD) vary. However, when neuropsychological deficits occur, they tend to be more prominent in motor/performance areas on both intelligence tests and other measures. In some disorders, adults performed significantly less well than younger patients. Further longitudinal follow-up will reveal whether this is due to declines throughout life or to improvements in diagnostics (especially newborn screening) and treatments in the younger generation of patients.

  15. Conceptual design of superferric magnets for PS2

    CERN Document Server

    Bottura, L; Maglioni, C; Parma, V; de Rijk, G; Rossi, L; Scandale, Walter; Serio, L; Tommasini, D

    2007-01-01

    We analyze feasibility and cost of a superferric magnet design for the PS2. Specifically, we provide the conceptual design of dipole and quadrupoles, including considerations on cryogenics and powering. The magnets have warm iron yoke, and cryostated superconducting coils embedded in the magnet, which reduces AC loss at cryogenic temperature. The superconductor has large Operating margin to endure beam loss and operating loads over a long period of time. Although conservative, and without any critical dependence on novel technology developments, this superconducting option appears to be attractive as a low-power alternative to the normal-conducting magnets that are the present baseline for the PS2 design. In addition it provides flexibility in the selection of flat-top duration at no additional cost. This study is the conclusion of the conceptual design work started within the scope of the CARE HHH-AMT activities, following inputs from the workshops ECOMAG and LUMI-06, and finally spurred by the recent discus...

  16. The evolution of internationalization pattern in national technology innovation system in G7 and its inspiration to China%G7国家创新体系国际化模式演化及对中国启示

    Institute of Scientific and Technical Information of China (English)

    孙玉涛; 苏敬勤

    2012-01-01

    以国家技术创新体系国际化概念界定为基础,采用研发强度、技术流动和创新能力作为国际化系统的表征变量,基于二维矩阵识别G7国家技术创新体系国际化模式演化路径;在中国与G7国家创新国际化比较参照系分析的基础上,提出以加拿大和日本国际化路径作为借鉴,中国技术创新体系国际化适合选择LLL→HLL→HHH路径。%This paper uses the RD intensity,technology flow and innovation capacity as the variables of the national technology innovation system(NTIS) internationalization,based on the concept of national innovation system internationalization.Then,it shows evolution paths of internationalization pattern in G7's NTIS using two-dimensional matrix method,and analyses the reference system between China and G7.The result is that China could follow the evolution path of Canada and Japan,and LLL→HLL→HHH path is good choice for China.

  17. Searching heavier Higgs boson via di-Higgs production at LHC Run-2

    Directory of Open Access Journals (Sweden)

    Lan-Chun Lü

    2016-04-01

    Full Text Available The discovery of a light Higgs particle h0(125 GeV opens up new prospect for searching heavier Higgs boson(s at the LHC Run-2, which will unambiguously point to new physics beyond the standard model (SM. We study the detection of a heavier neutral Higgs boson H0 via di-Higgs production channel at the LHC (14 TeV, H0→h0h0→WW⁎γγ. This directly probes the Hhh cubic Higgs interaction, which exists in most extensions of the SM Higgs sector. For the decay products of final states WW⁎, we include both pure leptonic mode WW⁎→ℓν¯ℓ¯ν and semi-leptonic mode WW⁎→qq¯′ℓν. We analyze signals and backgrounds by performing fast detector simulation for the full process pp→H→hh→WW⁎γγ→ℓν¯ℓ¯νγγ and pp→H→hh→WW⁎γγ→ℓνqq¯′γγ, over the mass range MH=250–600 GeV. For generic two-Higgs-doublet models (2HDM, we present the discovery reach of the heavier Higgs boson at the LHC Run-2, and compare it with the current Higgs global fit of the 2HDM parameter space.

  18. Renormalization of the Higgs sector in the triplet model

    CERN Document Server

    Aoki, Mayumi; Kikuchi, Mariko; Yagyu, Kei

    2012-01-01

    We study radiative corrections to the mass spectrum and the triple Higgs boson coupling in the model with an additional Y=1 triplet field. In this model, the vacuum expectation value for the triplet field is strongly constrained from the electroweak precision data, under which characteristic mass spectrum appear at the tree level; i.e., $m_{H^{++}}^2-m_{H^+}^2\\simeq m_{H^+}^2-m_A^2$ and $m_A^2\\simeq m_H^2$, where the CP-even ($H$), the CP-odd ($A$) and the doubly-charged ($H^{\\pm\\pm}$) as well as the singly-charged ($H^\\pm$) Higgs bosons are the triplet-like. We evaluate how the tree-level formulae are modified at the one-loop level. The $hhh$ coupling for the standard model-like Higgs boson ($h$) is also calculated at the one-loop level. One-loop corrections to these quantities can be large enough for identification of the model by future precision data at the LHC or the International Linear Collider.

  19. 上海大众途安巡航控制失效

    Institute of Scientific and Technical Information of China (English)

    陆建平

    2006-01-01

    @@ 一辆途安(1.8T)多用途轻型车,发动机型号BPL,发动机管理系统为博世公司ME7.5,手自排一体6挡变速器09G(HHH). 故障现象:启动发动机怠速运行,将集成在转向灯、变光开关控制手柄上的巡航控制(GRA)主开关由OFF推向ON,仪表显示屏内绿色的巡航灯亮,在车转弯时拨动转向灯开关手柄,当车完成转弯,其开关手柄自动回位时,巡航灯突然熄灭,再怎么拨弄GRA主开关,仪表板内巡航灯都不亮,无法对车辆当前行驶速度进行设定,巡航失效,进厂报修.

  20. Renormalization of the Higgs sector in the triplet model

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, Mayumi [Institute for Theoretical Physics, Kanazawa University, Kanazawa 920-1192 (Japan); Kanemura, Shinya; Kikuchi, Mariko [Department of Physics, University of Toyama, 3190 Gofuku, Toyama 930-8555 (Japan); Yagyu, Kei, E-mail: keiyagyu@jodo.sci.u-toyama.ac.jp [Department of Physics, University of Toyama, 3190 Gofuku, Toyama 930-8555 (Japan); National Central University, Physics and Center for Mathematics and Theoretical Physics, No. 300, Jhongda Rd., Jhongli, Taiwan (China)

    2012-08-14

    We study radiative corrections to the mass spectrum and the triple Higgs boson coupling in the model with an additional Y=1 triplet field. In this model, the vacuum expectation value for the triplet field is strongly constrained from the electroweak precision data, under which characteristic mass spectrum appear at the tree level; i.e., m{sub H{sup +}{sup +2}}-m{sub H{sup +2}} Asymptotically-Equal-To m{sub H{sup +2}}-m{sub A}{sup 2} and m{sub A}{sup 2} Asymptotically-Equal-To m{sub H}{sup 2}, where the CP-even (H), the CP-odd (A) and the doubly-charged (H{sup {+-}{+-}}) as well as the singly-charged (H{sup {+-}}) Higgs bosons are the triplet-like. We evaluate how the tree-level formulae are modified at the one-loop level. The hhh coupling for the standard model-like Higgs boson (h) is also calculated at the one-loop level. One-loop corrections to these quantities can be large enough for identification of the model by future precision data at the LHC or the International Linear Collider.

  1. 兔子! 站住!

    Institute of Scientific and Technical Information of China (English)

    海林

    2012-01-01

    <正>如果你有大把的业余时间,你会选择去干什么?泡吧?K歌?杀人游戏?统统都没意思了,一起来HaSh吧!如果有一天,在公园或者郊外,你看到这样的场景:一群自称"猎狗"的成年人在一起追逐一只或者两只也是成年人扮演的"兔子",还一边跑一边大喊口令,全然不顾旁人惊讶的眼神,游戏结束后违规的人还要被罚酒……你是不是会感觉好奇?一起来吧,他们就是在玩风靡了很久的Hash游戏。Hash是世界性的跑步健身运动,全称是"Hash House Harriers"(简称"Hash"、"HHH",或"3H"),是一项世界性的休闲活动,起源于1938年马

  2. The Experiment of Tonal Elements' Pitch on Tones of Mandarin%普通话声调调素的音高实验

    Institute of Scientific and Technical Information of China (English)

    冯青青

    2015-01-01

    An experimental method is taken to research tonal elements' pitch on modern Chinese mono-syllable tone in this paper,obtaining register feature and arch feature of the tonal element. There are some experimental results. Standard Chinese tones contain three tonal elements,i.e.,high register tonal element H,middle register tonal element M, and low register tonal element L. Standard Chinese tones are represented with tonal elements as followsTone one HHH,Tone two MHH,Tone three LLM,Tone four HML. The tonal element has arch,and every tonal element is flat arch. Tonal arch grundmodus are made up of flat arch.%通过实验方法研究普通话单字调调素的音高,得出调素的音区特征和曲拱特征。实验发现:普通话声调包含三个调素,分别是高音区调素 H、中音区调素 M 和低音区调素 L,普通话四个声调用调素表示为阴平 HHH、阳平 MHH、上声 LLH、去声 HML。调素有曲拱,每个调素都是平拱,各声调的曲拱样态由平拱组合而成。

  3. Generalized support varieties for finite group schemes

    CERN Document Server

    Friedlander, Eric M

    2011-01-01

    We construct two families of refinements of the (projectivized) support variety of a finite dimensional module $M$ for a finite group scheme $G$. For an arbitrary finite group scheme, we associate a family of {\\it non maximal rank varieties} $\\Gamma^j(G)_M$, $1\\leq j \\leq p-1$, to a $kG$-module $M$. For $G$ infinitesimal, we construct a finer family of locally closed subvarieties $V^{\\ul a}(G)_M$ of the variety of one parameter subgroups of $G$ for any partition $\\ul a$ of $\\dim M$. For an arbitrary finite group scheme $G$, a $kG$-module $M$ of constant rank, and a cohomology class $\\zeta$ in $\\HHH^1(G,M)$ we introduce the {\\it zero locus} $Z(\\zeta) \\subset \\Pi(G)$. We show that $Z(\\zeta)$ is a closed subvariety, and relate it to the non-maximal rank varieties. We also extend the construction of $Z(\\zeta)$ to an arbitrary extension class $\\zeta \\in \\Ext^n_G(M,N)$ whenever $M$ and $N$ are $kG$-modules of constant Jordan type.

  4. Higgs Boson Self-Coupling at High Energy $\\gamma \\gamma$ Collider

    CERN Document Server

    Gutierrez-Rodriguez, A; Sampayo, O A

    2011-01-01

    We analyzed the double production and the triple self-coupling of the standard model Higgs boson at future $\\gamma \\gamma$ collider energies, with the reactions $\\gamma\\gamma \\rightarrow f \\bar f HH$ $(f=b, t)$. We evaluated the total cross section for $f\\bar fHH$ and calculated the total number of events considering the complete set of Feynman diagrams at tree-level and for different values of the triple coupling $\\kappa\\lambda_{HHH}$. We have also analyzed the sensitivity for the considered reaction and we show the results as 95% C.L. regions in the $\\kappa-M_H$ plane for different values of the center of mass energy and different levels of background. The numerical computation was done for the energies which are expected to be available at a possible Future Linear $\\gamma\\gamma$ Collider with a center-of-mass energy 500-3000 $GeV$ and luminosities of 1 and $5 ab^{-1}$. We found that the number of events for the process $\\gamma\\gamma \\rightarrow t \\bar t HH$, taking into account the decay products of both $...

  5. DFNA5 and Hereditary Hearing Impairment%DFNA5与遗传性耳聋

    Institute of Scientific and Technical Information of China (English)

    金占国

    2011-01-01

    @@ 遗传性耳聋是危害人类健康的重大疾病之一,根据是否合并其他系统器官疾病,分为综合征性耳聋和非综合征性耳聋,而非综合征性耳聋具有很高的遗传异质性.迄今为止,常染色体显性遗传非综合征性耳聋(DFNA)已成功定位了64个位点,24个基因(Hereditary Hearing Loss Homepage:http://webhost.ua.ac.be/hhh/).第五个常染色体显性遗传非综合征性耳聋基因DFNA 5(OMIM 600994)于1995年在一个高频进展性听力下降的荷兰家系中首先定位在7p15[1],1998年确认了DFNA5的致聋基因[2].本文就已报道DFNA5的基因突变特点、家系的临床特征及目前对该基因功能的研究进展等方面进行综述.

  6. 不同液体复苏方法对孕兔失血性休克各脏器ATP酶活性的影响%Effects of hypotensive or aggressive resuscitation on tissue ATPase activity in pregnant rabbits with uncontrolled hemorrhagic shock

    Institute of Scientific and Technical Information of China (English)

    盛超; 余艳红; 秦薇; 赵克森

    2009-01-01

    目的:探讨限制性液体复苏对非控制性失血性休克孕兔腹腔内失血量、补液量、血细胞比容(Hct)及各脏器Na+-K+-ATP酶活性和Ca2+-Mg2+-ATP酶活性的改变,以分析其对休克后近期能量代谢的影响.方法:将30只孕中晚期新西兰大白兔随机分为5组:(1)假休克组(SS);(2)休克未处理组(SH);(3)传统复苏组(NS);(4)生理盐水限制性输液复苏组(NH);(5)高渗高胶液体限制性复苏组(HHH).实验设计分为休克期(TO-T30 min)、休克复苏期T30(T30-390 min)及休克复苏期T180(T90-T180 min).休克期:除SS组外各组动物均接受离断子宫系膜小动脉及颈动脉放血至平均动脉压(MAP)40-45 mmHg,制作非控制性失血性休克模型.休克复苏期T30:NS组接受生理盐水(4 mL/ks)及林格氏液快速输注以维持MAP在80 mmHg左右;NH、HHH组接受生理盐水(4 mL/kg)或高渗高胶液(6%羟乙基淀粉+7.5%氯化钠)(4 mL/kg)及林格氏液输注以维持MAP在60mmHg左右.休克复苏期T180:除SS组外各组动物均接受手术止血及输血输液治疗.实验中监测血细胞比容(Hct),统计腹腔内失血量、补液量.实验结束后处死动物取心脏、肺脏、肝脏、肾脏、小肠和骨骼肌组织检测Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活性.结果:腹腔内失血量与补液量:NH[(4.3±0.2)mL/kg,(47.2±4.1)mL/kg]与HHH[(4.1 ±0.3)mL/kg,(44.9±4.3)mL/kg]均明显低于NS[(5.5±0.2)mL/kg,(65.5±3.8)mL/lk].T180 min:Hct在NH(21.0%±2.1%)与HHH(21.5%±1.8%)均显著高于NS(14.2%±1.5%)及SH(12.5%±1.4%).失血性休克引起Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活性的升高;其中骨胳肌、心肌、肝、肾组织Na+-K+-ATP酶活力在NH(5.42±1.41,4.54±2.01,4.13±0.62,3.42±0.84)与HHH(3.97±0.91,2.94±0.66,3.22±1.42,3.03±0.53)均显著低于NS(7.34±1.41,6.23±1.53,6.11±0.97,5.82±0.69)与SH(9.11±0.52,8.40±1.08,7.04±1.13,6.55±1.45);肺及肠组织中,NH、HHH、NS组比较无显著差异.结论:孕兔非控制性失血性休克后导致能

  7. Measurement of Higgs couplings and self-coupling at the ILC

    CERN Document Server

    Tian, Junping

    2013-01-01

    In the Standard Model (SM) the couplings of the Higgs boson to SM particles and itself (self-couplings) are uniquely specified once the masses of the particles in question as well as the Higgs boson mass are given. Precision measurements of these couplings in the future collider experiments are the key to either verifying the mechanism of the electroweak symmetry breaking in the SM or uncovering physics beyond the SM. This article gives an overview of how various Higgs couplings will be measured at the ILC. Emphasis is put on the ILC's capability of performing fully model independent determination of absolute $HZZ$ and $HWW$ couplings, the Higgs total width, and hence various other Higgs couplings, which cover essentially all the crucial ones including the top-Yukawa coupling $Htt$ and the trilinear Higgs self-coupling $\\lambda_{HHH}$. The strategy to get the best precision measurements at the ILC is through staged running, which provides many independent $\\sigma\\times\\mathrm{Br}$ measurements for different p...

  8. LHC Upgrade Scenarios

    CERN Document Server

    Zimmermann, F

    2007-01-01

    The EU CARE-HHH and US-LARP studies for an LHC luminosity upgrade aim at increasing the peak luminosity by a factor of 10, to 1035 cm-2s-1. The luminosity can be raised by rebuilding the interaction regions (IRs) in combination with a consistent change of beam parameters. In addition to advanced low-beta quadrupoles, the upgraded IRs may accommodate other new elements such as slim s.c. dipoles or quadrupoles embedded deep inside the detectors, global low-angle crab cavities, and wire compensators of long-range beam-beam effects. Important constraints on the upgrade path are the maximum acceptable number of detector pile-up events, favoring many closely spaced bunches, and the heat load on the cold-magnet beam screens, pointing towards fewer and more intense bunches. In order to translate the increased peak luminosity into a correspondingly higher integrated luminosity, the upgrade of the LHC ring should be complemented by an upgrade of the injector complex. I will present preferred upgrade scenarios for the L...

  9. Benchmarks for Higgs Pair Production and Heavy Higgs Searches in the Two-Higgs-Doublet Model of Type II

    CERN Document Server

    Baglio, Julien; Nierste, Ulrich; Wiebusch, Martin

    2014-01-01

    The search for additional Higgs particles and the exact measurements of Higgs (self-)couplings is a major goal of future collider experiments. In this paper we investigate the possible sizes of new physics signals in these searches in the context of the $CP$-conserving two-Higgs doublet model of type II. Using current constraints from flavour, electroweak precision, and Higgs signal strength data, we determine the allowed sizes of the triple Higgs couplings and the branching fractions of the heavy Higgs bosons into lighter Higgs bosons. Identifying the observed Higgs resonance with the light $CP$-even 2HDM Higgs boson $h$, we find that the $hhh$ coupling cannot exceed its SM value, but can be reduced by a factor of 0.56 at the 2 $\\sigma$ level. The branching fractions of the heavy neutral Higgs bosons $H$ and $A$ into two-fermion or two-vector-boson final states can be reduced by factors of 0.4 and 0.01, respectively, if decays into lighter Higgs boson are possible and if the mass of the decaying Higgs is bel...

  10. Evaluation of halothane as stressor agent in poultry / Avaliação do halotano como agente estressor em frangos

    Directory of Open Access Journals (Sweden)

    Massami Shimokomaki

    2010-07-01

    Full Text Available Studies have been demonstrating in poultry, the existence of at least two causes for the formation of PSE meat: genetic through the sensibility towards halothane and the environmental factor in particular the temperature as the main factor. Thus the objective of this work was to evaluate halothane as stressor agent for broiler concomitantly to evaluating the PSE incidence by submitting these birds to thermal stress. In this experiment, 24 broilers of commercial lineage were divided in 6 animals for 4 treatments: HHH, broilers submitted to halothane test and slaughtered 1h after this test; HET broilers submitted to halothane at 35°C/1h after 48h of halothane test followed by the birds slaughtering; EET, broilers submitted to thermal stress and slaughtered immediately after this treatment, and finally the control treatment (CCC where broilers were not submitted to halothane test nor to thermal stress as control. The initial pH of Pectoralis major m, was evaluated 30 min post mortem and the pH final, color, (L*, a*, b* water holding capacity (WHC, and R value analysis were carried out after 24h of storage of fillet samples at 40C. The pH24h was higher (p ? 0.05 for CCC samples in comparison to other treatments and R value was higher for birds under HET and EET treatments in comparison to CCC (p ? 0.05 suggesting that the rigor mortis was more rapid in samples from birds submitted to thermal stress. The HHH, HET, and EET treatments presented 4 birds each with PSE meat and 2 broilers from CCC treatment originated PSE meat showing the influence not only halothane but also the thermal stress over broilers welfare. Finally, results demonstrated that halothane is a stressor agent as well as the thermal stress and both promoted dramatic biochemical changes bringing about the formation of broiler PSE meat. Resultados vêm mostrando uma direta relação entre a sensibilidade ao halotano e a ocorrência de filés PSE em aves, que pode ser originado pela

  11. Radiative corrections to the Triple Higgs Coupling in the Inert Higgs Doublet Model

    CERN Document Server

    Arhrib, Abdesslam; Falaki, Jaouad El; Jueid, Adil

    2015-01-01

    We investigate the implication of the recent discovery of a Higgs-like particle in the first phase of the LHC Run 1 on the Inert Higgs Doublet Model (IHDM). The determination of the Higgs couplings to SM particles and its intrinsic properties will get improved during the new LHC Run 2 starting this year. The new LHC Run 2 would also shade some light on the triple Higgs coupling. Such measurement is very important in order to establish the details of the electroweak symmetry breaking mechanism. Given the importance of the Higgs couplings both at the LHC and $e^+e^-$ Linear Collider machines, accurate theoretical predictions are required. We study the radiative corrections to the triple Higgs coupling $hhh$ and to $hZZ$, $hWW$ couplings in the context of the IHDM. By combining several theoretical and experimental constraints on parameter space, we show that extra particles might modify the triple Higgs coupling near threshold regions. Finally, we discuss the effect of these corrections on the double Higgs produ...

  12. Ab initio coordination chemistry for nickel chelation motifs.

    Directory of Open Access Journals (Sweden)

    R Jesu Jaya Sudan

    Full Text Available Chelation therapy is one of the most appreciated methods in the treatment of metal induced disease predisposition. Coordination chemistry provides a way to understand metal association in biological structures. In this work we have implemented coordination chemistry to study nickel coordination due to its high impact in industrial usage and thereby health consequences. This paper reports the analysis of nickel coordination from a large dataset of nickel bound structures and sequences. Coordination patterns predicted from the structures are reported in terms of donors, chelate length, coordination number, chelate geometry, structural fold and architecture. The analysis revealed histidine as the most favored residue in nickel coordination. The most common chelates identified were histidine based namely HHH, HDH, HEH and HH spaced at specific intervals. Though a maximum coordination number of 8 was observed, the presence of a single protein donor was noted to be mandatory in nickel coordination. The coordination pattern did not reveal any specific fold, nevertheless we report preferable residue spacing for specific structural architecture. In contrast, the analysis of nickel binding proteins from bacterial and archeal species revealed no common coordination patterns. Nickel binding sequence motifs were noted to be organism specific and protein class specific. As a result we identified about 13 signatures derived from 13 classes of nickel binding proteins. The specifications on nickel coordination presented in this paper will prove beneficial for developing better chelation strategies.

  13. Coronary Arteries Segmentation Based on the 3D Discrete Wavelet Transform and 3D Neutrosophic Transform

    Directory of Open Access Journals (Sweden)

    Shuo-Tsung Chen

    2015-01-01

    Full Text Available Purpose. Most applications in the field of medical image processing require precise estimation. To improve the accuracy of segmentation, this study aimed to propose a novel segmentation method for coronary arteries to allow for the automatic and accurate detection of coronary pathologies. Methods. The proposed segmentation method included 2 parts. First, 3D region growing was applied to give the initial segmentation of coronary arteries. Next, the location of vessel information, HHH subband coefficients of the 3D DWT, was detected by the proposed vessel-texture discrimination algorithm. Based on the initial segmentation, 3D DWT integrated with the 3D neutrosophic transformation could accurately detect the coronary arteries. Results. Each subbranch of the segmented coronary arteries was segmented correctly by the proposed method. The obtained results are compared with those ground truth values obtained from the commercial software from GE Healthcare and the level-set method proposed by Yang et al., 2007. Results indicate that the proposed method is better in terms of efficiency analyzed. Conclusion. Based on the initial segmentation of coronary arteries obtained from 3D region growing, one-level 3D DWT and 3D neutrosophic transformation can be applied to detect coronary pathologies accurately.

  14. Scenarios for the LHC Upgrade

    CERN Document Server

    Scandale, Walter

    2008-01-01

    The projected lifetime of the LHC low-beta quadrupoles, the evolution of the statistical error halving time, and the physics potential all call for an LHC luminosity upgrade by the middle of the coming decade. In the framework of the CARE-HHH network three principal scenarios have been developed for increasing the LHC peak luminosity by more than a factor of 10, to values above 1035 cm−2s−1. All scenarios imply a rebuilding of the high-luminosity interaction regions (IRs) in combination with a consistent change of beam parameters. However, their respective features, bunch structures, IR layouts, merits and challenges, and luminosity variation with β∗ differ substantially. In all scenarios luminosity leveling during a store would be advantageous for the physics experiments. An injector upgrade must complement the upgrade measures in the LHC proper in order to provide the beam intensity and brightness needed as well as to reduce the LHC turnaround time for higher integrated luminosity.

  15. Radiative corrections to the triple Higgs coupling in the inert Higgs doublet model

    Science.gov (United States)

    Arhrib, Abdesslam; Benbrik, Rachid; El Falaki, Jaouad; Jueid, Adil

    2015-12-01

    We investigate the implication of the recent discovery of a Higgs-like particle in the first phase of the LHC Run 1 on the Inert Higgs Doublet Model (IHDM). The determination of the Higgs couplings to SM particles and its intrinsic properties will get improved during the new LHC Run 2 starting this year. The new LHC Run 2 would also shade some light on the triple Higgs coupling. Such measurement is very important in order to establish the details of the electroweak symmetry breaking mechanism. Given the importance of the Higgs couplings both at the LHC and e + e - Linear Collider machines, accurate theoretical predictions are required. We study the radiative corrections to the triple Higgs coupling hhh and to hZZ, hW W couplings in the context of the IHDM. By combining several theoretical and experimental constraints on parameter space, we show that extra particles might modify the triple Higgs coupling near threshold regions. Finally, we discuss the effect of these corrections on the double Higgs production signal at the e + e - LC and show that they can be rather important.

  16. Searching heavier Higgs boson via di-Higgs production at LHC Run-2

    Science.gov (United States)

    Lü, Lan-Chun; Du, Chun; Fang, Yaquan; He, Hong-Jian; Zhang, Huijun

    2016-04-01

    The discovery of a light Higgs particle h0 (125 GeV) opens up new prospect for searching heavier Higgs boson(s) at the LHC Run-2, which will unambiguously point to new physics beyond the standard model (SM). We study the detection of a heavier neutral Higgs boson H0 via di-Higgs production channel at the LHC (14 TeV), H0 →h0h0 → WW* γγ. This directly probes the Hhh cubic Higgs interaction, which exists in most extensions of the SM Higgs sector. For the decay products of final states WW*, we include both pure leptonic mode WW* → ℓ ν bar ℓ bar ν and semi-leptonic mode WW* → qqbar‧ ℓν. We analyze signals and backgrounds by performing fast detector simulation for the full process pp → H → hh → WW* γγ → ℓ ν bar ℓ bar νγγ and pp → H → hh → WW* γγ → ℓνqqbar‧ γγ, over the mass range MH = 250- 600 GeV. For generic two-Higgs-doublet models (2HDM), we present the discovery reach of the heavier Higgs boson at the LHC Run-2, and compare it with the current Higgs global fit of the 2HDM parameter space.

  17. Piezoelectricity and rotostriction through polar and non-polar coupled instabilities in bismuth-based piezoceramics

    Science.gov (United States)

    Acosta, Matias; Schmitt, Ljubomira A.; Cazorla, Claudio; Studer, Andrew; Zintler, Alexander; Glaum, Julia; Kleebe, Hans-Joachim; Donner, Wolfgang; Hoffman, Mark; Rödel, Jürgen; Hinterstein, Manuel

    2016-07-01

    Coupling of order parameters provides a means to tune functionality in advanced materials including multiferroics, superconductors, and ionic conductors. We demonstrate that the response of a frustrated ferroelectric state leads to coupling between order parameters under electric field depending on grain orientation. The strain of grains oriented along a specific crystallographic direction, , is caused by converse piezoelectricity originating from a ferrodistortive tetragonal phase. For hhh> oriented grains, the strain results from converse piezoelectricity and rotostriction, as indicated by an antiferrodistortive instability that promotes octahedral tilting in a rhombohedral phase. Both strain mechanisms combined lead to a colossal local strain of (2.4 ± 0.1) % and indicate coupling between oxygen octahedral tilting and polarization, here termed “rotopolarization”. These findings were confirmed with electromechanical experiments, in situ neutron diffraction, and in situ transmission electron microscopy in 0.75Bi1/2Na1/2TiO3-0.25SrTiO3. This work demonstrates that polar and non-polar instabilities can cooperate to provide colossal functional responses.

  18. Testing the dark matter scenario in the inert doublet model by future precision measurements of the Higgs boson couplings

    CERN Document Server

    Kanemura, Shinya; Sakurai, Kodai

    2016-01-01

    We evaluate radiative corrections to the Higgs boson couplings in the inert doublet model, in which the lightest component of the $Z_2^{}$ odd scalar doublet field can be a dark matter candidate. The one-loop contributions to the $hVV$, $hff$ and $hhh$ couplings are calculated in the on-shell scheme, where $h$ is the Higgs boson with the mass 125 GeV, $V$ represents a weak gauge boson and $f$ is a fermion. We investigate how the one-loop corrected Higgs boson couplings can be deviated from the predictions in the standard model under the constraints from perturbative unitarity and vacuum stability in the scenario where the model can explain current dark matter data. When the mass of the dark matter is slightly above a half of the Higgs boson mass, it would be difficult to test the model by the direct search experiments for dark matter. We find that in such a case the model can be tested at future collider experiments by either the direct search of heavier inert particles or precision measurements of the Higgs ...

  19. How To Use Differentiated Instruction with Students with Developmental Disabilities in the General Education Classroom. DDD Prism Series.

    Science.gov (United States)

    Gartin, Barbara C.; Murdick, Nikki L.; Imbeau, Marcia; Perner, Darlene E.

    This book discusses how educators can achieve inclusive classrooms that give students with different abilities the maximum opportunity for growth. It provides frameworks for planning learning environments, content, process, and products that enable students with learning challenges to succeed with meaningful curriculum. Decision-making guidelines…

  20. Surface and Interface Stress Analysis of Thin Film by X-Ray Diffraction%薄膜表面和界面应力的X射线衍射分析(中)

    Institute of Scientific and Technical Information of China (English)

    王宁; 王超群

    2011-01-01

    薄膜表面和界面应力的测量是近年来的热点课题,原则上,薄膜与体材的应力分析方法并无差别,可以通过X射线衍射进行测量.本文以有关薄膜和表面区X射线应力分析的专题评述为蓝本,解读有关依赖于试样和测量条件的分析方法和测量策略.为此,将推荐若干实用的测试方法:对于无织构和宏观弹性各向同性薄膜试样,可采用掠入射多衍射线的薄膜应力分析方法,在这种情况下,当用小入射角时,常规的sin2Ψ法可以使用;对于(hhh)和(h00)的应变测量,具有准各向同性的优点,可以直接采用sin2Ψ法;对于有织构试样,材料呈宏观弹性各向异性,可采用晶体群方法.这些方法对于薄膜、多层膜、硬质涂层或体材近表面区的应力分析,具有十分重要的理论价值和使用意义,也可用于新型电子薄膜材料等的应力分析,为其性能改善和控制提供理论依据.%The measurement of the thin film surface and interface stress is a hot subject in recent years. In principle, there is no significant difference between the stress measurement of thin film and bulk material, which can both be determined by X-ray diffraction. By reference to the literatures involving the stress measurement of thin film and surface region, various analysis methods and measurement strategies in dependence on specimen and measurement conditions, are summarized and evaluated in this research. Some practical measurement methods are commended. For macroscopically elastically isotropic and untextured specimens, the thin film stress can be analysized by grazing incident multiple X-ray diffraction method. At this condition, when the incident angle is small, conventional sin2ψ method can be applied. For (hhh) and (h00) strain measurement, due to the advantage of quasi-isotropy, the sin2ψ method can be directly used. For the textured specimen, the material is macroscopically elastically anisotropic. Crystallite group

  1. Surface and Interface Stress Analysis of Thin Film by X-Ray Diffraction%薄膜表面和界面应力的X射线衍射分析(上)

    Institute of Scientific and Technical Information of China (English)

    王宁; 王超群

    2011-01-01

    薄膜表面和界面应力的测量是近年来的热点课题,原则上,薄膜与体材的应力分析方法并无差别,可以通过X射线衍射进行测量.本文以有关薄膜和表面区X射线应力分析的专题评述为蓝本,解读有关依赖于试样和测量条件的分析方法和测量策略.为此,将推荐若干实用的测试方法:对于无织构和宏观弹性各向同性薄膜试样,可采用掠入射多衍射线的薄膜应力分析方法,在这种情况下,当用小入射角时,常规的Sin2ψ法可以使用;对于(hhh)和(h00)的应变测量,具有准各向同性的优点,可以直接采用sin2ψ法;对于有织构试样,材料呈宏观弹性各向异性,可采用晶体群方法.这些方法对于薄膜、多层膜、硬质涂层或体材近表面区的应力分析,具有十分重要的理论价值和使用意义,也可用于新型电子薄膜材料等的应力分析,为其性能改善和控制提供理论依据.%The measurement of the thin film surface and interface stress is a hot subject in recent years. In principle, there is no significant difference between the stress measurement of thin film and bulk material, which can both be determined by X-ray diffraction. By reference to the literatures involving the stress measurement of thin film and surface region, various analysis methods and measurement strategies in dependence on specimen and measurement conditions, are summarized and evaluated in this research. Some practical measurement methods are commended. For macroscopically elastically isotropic and untextured specimens, the thin film stress can be analysized by grazing incident multiple X-ray diffraction method. At this condition, when the incident angle is small, conventional sin2Ψmethod can be applied. For (hhh) and (hOO) strain measurement, due to the advantage of quasi-isotropy, the sin2Ψ method can be directly used. For the textured specimen, the material is macroscopically elastically anisotropic. Crystallite group method

  2. Effect of hypotensive fluid resuscitation on microcirculation in an uncontrolled hemorrhagic shock of pregnant rabbits%限制性输液对失血性休克孕兔微循环灌注的影响

    Institute of Scientific and Technical Information of China (English)

    秦薇; 余艳红; 王晨虹

    2010-01-01

    Objective To study the effects of hypotensive resuscitation on microvascular perfusion in a clinically relevant model of uncontrolled hemorrhagic shock in pregnancy. Methods Thirty New Zealand white rabbits at 15 -25 days, pregnanal age were randomly divided into three groups; Group normal saline traditional aggressive resuscitation ( NS), traditional aggressive resuscitation in the prehospital phase with a large quantity of normal saline and Ringer's solution to maintain mean arterial pressure (MAP) at the approximately 80 mm Hg ( 1 mm Hg = 0.133 kPa) level: Group normal saline hypotensive resuscitation (NH) and group hypertonic hyperosmotic hypotension resuscitation (HHH), hypotensive resuscitation in the prehospital phase with a bolus dose of 4 ml/kg normal saline or hypertonic hydroxyl ethyl starch (10% hydroxyl ethyl starch + 7.5% NaCl), followed by Ringer's solution to maintain MAP at 60 mm Hg.Production pregnant rabbit model with hemorrhagic shock. The experiment consisted of four phases:basic phase (0 miniutes), shock phase (0- 30 miniutes), prehospital phase (30- 90 miniutes) and hospital phase (90- 180 miniutes). Measurements: (1) arteriole and venule diameter were continuously monitored by microcirculatory detecting instrument; (2) functional capillary density (FCD) of each phase was expressed by the percentage of opening capillaries segments relative to basic phase; (3) blood pH, BE PCO2, PO2 in pregnant rabbits were determined with a Medica Easy Blood Gas Analyzer. Results ( 1 )There were no significant differences among three groups in arteriole and venule diameter at baseline ( P >0.05 ). After hemorrhagic shock arteriole diameter were NS ( 50.8 ± 5.6) μm, NH (47.6 ± 3.7 ) μm, HHH (51.3 ±2.4)μm, respectively, with no significant differences between groups(P >0.05). At the end of prehospital resuscitation phase and hospital resuscitation phase, significant differences were found in arteriole diameter in group NS(52.8 ± 4.9, 56.0 ± 3.8 )

  3. 薄膜表面和界面应力的X射线衍射分析(下)%Surface and Interface Stress Analysis of Thin Film by X-ray Diffraction

    Institute of Scientific and Technical Information of China (English)

    王宁; 王超群

    2011-01-01

    The measurement of the thin film surface and interface stress is a hot subject in recent years. In principle, there is no significant difference between the stress measurement of thin film and bulk material, which can both be determined by X-ray diffraction. By reference to the literatures involving the stress measurement of thin film and surface region, various analysis methods and measurement strategies in dependence on specimen and measurement conditions, are summarized and evaluated in this research. Some practical measurement methods are commended. For macroscopically e-lastically isotropic and untextured specimens, the thin film stress can be analysized by grazing incident multiple X-ray diffraction method. At this condition, when the incident angle is small, conventional siivty method can be applied. For (hhh) and (MX)) strain measurement, due to the advantage of quasi-isotropy, the sirn)< method can be directly used. For the textured specimen, the material is macroscopically elastically anisotropic. Crystallite group method can be applied. These methods have very important theoretical and practical value for the stress analysis of thin film, multilayer, hard coating, or near surface area of bulk material. They can also be used for the stress analysis of new electronic thin film materials, and supply theoretical basis for the control and improvement of performance.%薄膜表面和界面应力的测量是近年来的热点课题,原则上,薄膜与体材的应力分析方法并无差别,可以通过X射线衍射进行测量.本文以有关薄膜和表面区X射线应力分析的专题评述为蓝本,解读有关依赖于试样和测量条件的分析方法和测量策略.为此,将推荐若干实用的测试方法:对于无织构和宏观弹性各向同性薄膜试样,可采用掠入射多衍射线的薄膜应力分析方法,在这种情况下,当用小入射角时,常规的sin2ψ法可以使用;对于(hhh)和(h00)的应变测量,具有准各向同性

  4. Molecular characterization of NAD+-dependent DNA ligase from Wolbachia endosymbiont of lymphatic filarial parasite Brugia malayi.

    Directory of Open Access Journals (Sweden)

    Nidhi Shrivastava

    Full Text Available The lymphatic filarial parasite, Brugia malayi contains Wolbachia endobacteria that are essential for development, viability and fertility of the parasite. Therefore, wolbachial proteins have been currently seen as the potential antifilarial drug targets. NAD(+-dependent DNA ligase is characterized as a promising drug target in several organisms due to its crucial, indispensable role in DNA replication, recombination and DNA repair. We report here the cloning, expression and purification of NAD(+-dependent DNA ligase of Wolbachia endosymbiont of B. malayi (wBm-LigA for its molecular characterization. wBm-LigA has all the domains that are present in nearly all the eubacterial NAD(+-dependent DNA ligases such as N-terminal adenylation domain, OB fold, helix-hairpin-helix (HhH and BRCT domain except zinc-binding tetracysteine domain. The purified recombinant protein (683-amino acid was found to be biochemically active and was present in its native form as revealed by the circular dichroism and fluorescence spectra. The purified recombinant enzyme was able to catalyze intramolecular strand joining on a nicked DNA as well as intermolecular joining of the cohesive ends of BstEII restricted lamda DNA in an in vitro assay. The enzyme was localized in the various life-stages of B. malayi parasites by immunoblotting and high enzyme expression was observed in Wolbachia within B. malayi microfilariae and female adult parasites along the hypodermal chords and in the gravid portion as evident by the confocal microscopy. Ours is the first report on this enzyme of Wolbachia and these findings would assist in validating the antifilarial drug target potential of wBm-LigA in future studies.

  5. Classification and evolutionary history of the single-strand annealing proteins, RecT, Redβ, ERF and RAD52

    Directory of Open Access Journals (Sweden)

    Aravind L

    2002-03-01

    Full Text Available Abstract Background The DNA single-strand annealing proteins (SSAPs, such as RecT, Redβ, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. Recently, they have been shown to form similar helical quaternary superstructures. However, despite the functional similarities between these diverse SSAPs, their actual evolutionary affinities are poorly understood. Results Using sensitive computational sequence analysis, we show that the RecT and Redβ proteins, along with several other bacterial proteins, form a distinct superfamily. The ERF and Rad52 families show no direct evolutionary relationship to these proteins and define novel superfamilies of their own. We identify several previously unknown members of each of these superfamilies and also report, for the first time, bacterial and viral homologs of Rad52. Additionally, we predict the presence of aberrant HhH modules in RAD52 that are likely to be involved in DNA-binding. Using the contextual information obtained from the analysis of gene neighborhoods, we provide evidence of the interaction of the bacterial members of each of these SSAP superfamilies with a similar set of DNA repair/recombination protein. These include different nucleases or Holliday junction resolvases, the ABC ATPase SbcC and the single-strand-binding protein. We also present evidence of independent assembly of some of the predicted operons encoding SSAPs and in situ displacement of functionally similar genes. Conclusions There are three evolutionarily distinct superfamilies of SSAPs, namely the RecT/Redβ, ERF, and RAD52, that have different sequence conservation patterns and predicted folds. All these SSAPs appear to be primarily of bacteriophage origin and have been acquired by numerous phylogenetically distant cellular genomes. They generally occur in predicted operons encoding one or more of a set of conserved DNA recombination proteins that appear to be the principal functional

  6. The Rashba effect on a double-barrier spin polarizer

    Energy Technology Data Exchange (ETDEWEB)

    Makler, Sergio S. [Instituto de Fisica, Universidade Federal Fluminense, Campus da Praia Vermelha, 24210-340 Niteroi-RJ (Brazil)]. E-mail: sergio@if.uff.br; Guilherme Zelcovit, Joao [Instituto de Fisica, Universidade do Estado de Rio de Janeiro, RJ (Brazil); Boselli, Marco A. [Departamento de Fisica, Universidade Federal de Ouro Preto, MG (Brazil); Cunha Lima, Ivan C. da [Instituto de Fisica, Universidade do Estado de Rio de Janeiro, RJ (Brazil)

    2004-12-31

    The Rashba effect on a double-barrier spin polarizer is considered using a formalism that produces accurate results with little computational effort. In previous articles, we proposed a spin polarizer consisting of a well made of a dilute magnetic semiconductor (DMS) enclosed by two non-magnetic barriers. In the absence of Rashba effect, the magnetization of the well produces totally polarized electronic levels separated by 0.15eV. The highest steady magnetic field obtained in a laboratory could not produce a Zeeman splitting so big. As a consequence the calculated currents are almost totally polarized. The Rashba spin-orbit Hamiltonian produces a spin flip. Therefore, the levels at the well have not well-defined spin polarization and the currents are less polarized. The device presented here would be useful for spintronics because there are DMS ferromagnetic at room temperature. Our tight-binding Hamiltonian, including the Rashba term, isH=HK+HP+HE+HM+Hh-i+Hh-h+HR.The first term is the kinetic energy. HP describes the double-barrier profile and the third term represent the electric field due to the applied bias. The magnetic HM, the hole-impurity Hh-i and the hole-hole Hh-h terms are included in the mean field approximation. The profile and the charge distribution are calculated self-consistently.By using a decimation formalism, all these terms are treated exactly. Finally, the Rashba term HR is very small. Therefore, it is treated using second order perturbation theory. The calculation confirm that the Rashba effect on the currents is of second order. Consequently, the resulting depolarization is very small.

  7. 非综合征型遗传性耳聋基因的研究进展及相关网络资源

    Institute of Scientific and Technical Information of China (English)

    徐悦凡; 杨字

    2001-01-01

    耳聋是一种最常见的人类感觉系统缺陷,70%的遗传性耳聋属于非综合征型听力缺损。据估计非综合征型遗传性耳聋基因总数在100个以上,迄今已经有大约80个基因位点被绘制于人类染色体上.18个基因被鉴定。本文系统地介绍了已鉴定的18个非综合征型耳聋基因,这些基因分别编码两个线粒体基因12S rRNA和tRNA Set,COCH.COLllA2.DFNA5,diaphanous(D1APH),三个间隙连接蛋白(GIB2,GIB3和GJB6),钾离子通道亚基4(KCNQ4),两个非常规肌球蛋白(MY07A和MY015),Otoferlin(OTOF),pendrin(PDS),两个POU域转录因子(POU3F4和POU4F3).α-tectorin(TECTA)以及跨膜丝氨酸蛋白酶3(TMPRSS3),并列举了如遗传性听力缺损网站(Hereditary Heating Loss Homepage,Http://www uia.ac.be/dnalab/hhh)等与遗传性耳聋相关的部分网络资源以供参考。

  8. Enhancement of DNaseI Salt Tolerance by Mimicking the Domain Structure of DNase from an Extremely Halotolerant Bacterium Thioalkalivibrio sp. K90mix.

    Directory of Open Access Journals (Sweden)

    Gediminas Alzbutas

    Full Text Available In our previous work we showed that DNaseI-like protein from an extremely halotolerant bacterium Thioalkalivibrio sp. K90mix retained its activity at salt concentrations as high as 4 M NaCl and the key factor allowing this was the C-terminal DNA-binding domain, which comprised two HhH (helix-hairpin-helix motifs. The further investigations revealed that this domain originated from proteins related to bacterial competence ComEA/ComE proteins. It is likely that in the course of evolution the DNA-binding domain from these proteins was fused to a metallo-β-lactamase superfamily domain. Very likely such domain organization having proteins subsequently "donated" the DNA-binding domain to bacterial DNases. In this study we have mimicked this evolutionary step by fusing bovine DNaseI and DNA-binding domains. We have created two fusions: one harboring the DNA-binding domain of DNaseI-like protein from Thioalkalivibrio sp. K90mix and the second one harboring the DNA-binding domain of bacterial competence protein ComEA from Bacillus subtilis. Both domains enhanced salt tolerance of DNaseI, albeit to different extent. Molecular modeling revealed the essential differences between their interaction with DNA shedding some light on the differences in salt tolerance. In this study we have enhanced salt tolerance of bovine DNaseI; thus, we successfully mimicked the Nature's evolutionary engineering that created the extremely halotolerant bacterial DNase. We have demonstrated that the newly engineered DNaseI variants can be successfully used in applications where activity of the wild type bovine DNaseI is impeded by buffers used.

  9. Enhancement of DNaseI Salt Tolerance by Mimicking the Domain Structure of DNase from an Extremely Halotolerant Bacterium Thioalkalivibrio sp. K90mix

    Science.gov (United States)

    Alzbutas, Gediminas; Kaniusaite, Milda; Lagunavicius, Arunas

    2016-01-01

    In our previous work we showed that DNaseI-like protein from an extremely halotolerant bacterium Thioalkalivibrio sp. K90mix retained its activity at salt concentrations as high as 4 M NaCl and the key factor allowing this was the C-terminal DNA-binding domain, which comprised two HhH (helix-hairpin-helix) motifs. The further investigations revealed that this domain originated from proteins related to bacterial competence ComEA/ComE proteins. It is likely that in the course of evolution the DNA-binding domain from these proteins was fused to a metallo-β-lactamase superfamily domain. Very likely such domain organization having proteins subsequently “donated” the DNA-binding domain to bacterial DNases. In this study we have mimicked this evolutionary step by fusing bovine DNaseI and DNA-binding domains. We have created two fusions: one harboring the DNA-binding domain of DNaseI-like protein from Thioalkalivibrio sp. K90mix and the second one harboring the DNA-binding domain of bacterial competence protein ComEA from Bacillus subtilis. Both domains enhanced salt tolerance of DNaseI, albeit to different extent. Molecular modeling revealed the essential differences between their interaction with DNA shedding some light on the differences in salt tolerance. In this study we have enhanced salt tolerance of bovine DNaseI; thus, we successfully mimicked the Nature’s evolutionary engineering that created the extremely halotolerant bacterial DNase. We have demonstrated that the newly engineered DNaseI variants can be successfully used in applications where activity of the wild type bovine DNaseI is impeded by buffers used. PMID:26939122

  10. 黄淮海地区植被生长季变化及其气候变化响应%The Change of Growing Season of the Vegetation in Huanghe-Huaihe-Haihe Region and Its Responses to Climate Changes

    Institute of Scientific and Technical Information of China (English)

    陈怀亮; 刘玉洁; 杜子璇; 刘忠阳; 邹春辉

    2011-01-01

    Using the each ten-day data of NOAA/AVHRR from 1981 to 2000 and adopting the Maximum-Slope method, Curve-Fitting method and stepwise regression, the beginning and ending of the growth season of the vegetations in the Huanghe-Huaihe-Haihe (HHH) region are analyzed. Meanwhile, the pixel by pixel JNDv map is worked out with typical bands as the sample. Through analyzing the change of green wave and brown wave, the changing rules of vegetation activities and its responses to climate changes in the past 20 years are revealed. The growth season in HHH region starts at the last 10 days of March with /Ndv0. 19604 and ends at the first 10 days of November with INDV 0. 22899 on average. The tendency is that the growing season has prolonged obviously by starting earlier and earlier, while ending later and later from 1982 to 2000. The average Indv for the vegetation in the researched area in the past 20 years is generally increasing, especially in spring. According to the Indv map of typical bands as the sample worked out with the pixel by pixel, the green wave changes from south to north during January-July on the band of 116°E, the maximum of Indv occurs in August and decreases gradually after September. On the band of 36°N, to the east and nearby 116°E , the Indv has two peaks because of two crops a year, which is obviously different from other regions. The two peaks occur in April and August and they become clearer and clearer from 1982 to 2000, especially in agriculture area. However, the two peaks are not obvious to the north of 38. 5°N, in the area of Beijing, Tianjin and the mountain areas, and the peak value of early summer is lower than that of autumn. In agriculture area, the peak interval of green wave is broadening with the time passing by, and it's more obviously from south to north. With the time passing by, the green wave of the critical value of the growth season in the area changes from south to north, while the emergence of brown wave prolongs from north

  11. Measurement of the Relative Branching Fractions of Bbar --> D/D*/D** l^- anti-nu_l Decays in Events with a Fully Reconstructed B Meson

    CERN Document Server

    Aubert, B; Abrams, G S; Adye, T; Ahmed, S; Alam, M S; Albert, J; Aleksan, R; Allen, M T; Allison, J; Altenburg, D D; Anderson, J; Andreotti, M; Angelini, C; Anulli, F; Arnaud, N; Asgeirsson, D J; Aston, D; Azzolini, V; Baak, M A; Back, J J; Baldini-Ferroli, R; Band, H R; Banerjee, Sw; Baracchini, E; Bard, D J; Barlow, N R; Barlow, R J; Bartoldus, R; Batignani, G; Battaglia, M; Bauer, J M; Bechtle, P; Beck, T W; Behera, P K; Bellini, F; Ben-Haim, E; Benelli, G; Bequilleux, J; Berger, N; Bernard, D; Berryhill, J W; Bettarini, S; Bettoni, D; Bevan, A J; Bhuyan, B; Bianchi, F; Biasini, M; Biesiada, J; Blanc, F; Blaylock, G; Blinov, V E; Bloom, P C; Blount, N L; Bomben, M; Bondioli, M; Bonneaud, G R; Bosisio, L; Boutigny, D; Bozzi, C; Brandt, T; Brau, J E; Briand, H; Brown, D N; Brunet, S; Buchanan, C; Bugg, W; Bukin, A D; Bula, R; Burchat, P R; Button-Shafer, J; Buzzo, A; Bóna, M; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Carpinelli, M; Cartaro, C; Castelli, G; Cavoto, G; Cecchi, A; Cenci, R; Cervelli, A; Chai, X; Chaisanguanthum, K S; Charles, M J; Chauveau, J; Chavez, C A; Chen, C; Chen, E; Chen, S; Chen, X; Chen, X R; Cheng, C H; Chia, Y M; Cibinetto, G; Clark, P J; Claus, R; Cochran, J; Coleman, J P; Contri, R; Convery, M R; Corwin, L A; Cossutti, F; Cottingham, W N; Covarelli, R; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L; Cunha, A; Curry, S; Côté, D; D'Orazio, A; Dahmes, B; Dallapiccola, C; Dasu, S; Dauncey, P D; David, P; Davier, M; Davis, C L; De Nardo, Gallieno; De Sangro, R; Del Amo-Sánchez, P; Del Buono, L; Del Re, D; Della Ricca, G; Denig, A G; Di Lodovico, F; Di Marco, E; Dingfelder, J C; Dong, L; Dorfan, J; Druzhinin, V P; Dubitzky, R S; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W; Dvoretskii, A; Ebert, M; Eckmann, R; Edgar, C L; Edwards, A J; Eigen, G; Eisner, A M; Elmer, P; Emery, S; Ernst, J A; Escalier, M; Eschenburg, V; Eschrich, I; Eyges, V; Fabozzi, F; Faccini, R; Fang, F; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Fisher, P H; Flacco, C J; Flack, R L; Flächer, H U; Flood, K T; Ford, W T; Forster, I J; Forti, F; Foulkes, S D; Franchini, P; Franek, B; Frey, R; Fritsch, M; Fry, J R; Fulsom, B G; Gabareen, A M; Gabathuler, E; Gagliardi, N; Gaidot, A; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Garra Tico, J; Gary, J W; Gaspero, M; Gaz, A; George, K A; Giorgi, M A; Gladney, L; Glanzman, T; Godang, R; Golubev, V B; Gowdy, S J; Gradl, W; Graham, M T; Graugès-Pous, E; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Z J; Haire, M; Hamano, K; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Hartfiel, B L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hirschauer, J F; Hitlin, D G; Hollar, J J; Hong, T M; Honscheid, K; Hopkins, D A; Hrynóva, T; Hufnagel, D; Hutchcroft, D E; Höcker, A; Igonkina, O; Innes, W R; Izen, J M; Jackson, P D; Jackson, P S; Jacobsen, R G; Jain, V; Jasper, H; Jawahery, A; Jessop, C P; Kadyk, J A; Kagan, H; Karyotakis, Yu; Kass, R; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Klose, V; Knecht, N S; Koch, H; Kolb, J A; Kolomensky, Yu G; Kovalskyi, D; Kowalewski, R V; Kozanecki, W; Kreisel, A; Krishnamurthy, M; Kroeger, R; Kroseberg, J; Kukartsev, G; Kutter, P E; La Vaissière, C de; Lacker, H M; Lae, C K; Lafferty, G D; Lanceri, L; Lange, D J; Lankford, A J; Latham, T E; Latour, E; Lau, Y P; Lazzaro, A; Le Diberder, F R; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Lewandowski, B; Li Gioi, L; Li, S; Li, X; Lista, L; Liu, F; Liu, H; Lo Vetere, M; LoSecco, J M; Lockman, W S; Lombardo, V; Long, O; Lopes-Pegna, D; Lopez-March, N; Lou, X C; Lu, M; Luitz, S; Lund, P; Luppi, E; Lusiani, A; Lutz, A M; Lynch, G; Lynch, H L; López, L; Lü, C; Lüth, V; MacFarlane, D B; Macri, M M; Mader, W F; Majewski, S A; Malcles, J; Mallik, U; Mancinelli, G; Mandelkern, M A; Manoni, E; Marchiori, G; Margoni, M; Marks, J; Marsiske, H; Martin, E C; Martínez-Vidal, F; Mattison, T S; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Mclachlin, S E; Meadows, B T; Menges, W; Merkel, J; Messner, R; Meyer, N T; Meyer, W T; Milanes, D A; Mir, L M; Mishra, K; Mohanty, G B; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morganti, M; Morganti, S; Morii, M; Morris, J P; Muheim, F; Müller, D R; Nagel, M; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nicholson, H; Nikolich, M B; Nogowski, R; Nugent, I M; O'Grady, C P; Ocariz, J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Oyanguren, A; Paar, H P; Pacetti, S; Palano, A; Palombo, F; Pan, B; Pan, Y; Panduro-Vazquez, W; Paoloni, E; Pappagallo, M; Park, W; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Pelliccioni, M; Perazzo, A; Perl, M; Peruzzi, I M; Petersen, B A; Petrella, A; Petzold, A; Piatenko, T; Piccolo, M; Piemontese, L; Pierini, M; Piredda, G; Playfer, S; Poireau, V; Polci, F; Pompili, A; Porter, F C; Posocco, M; Prell, S; Prencipe, E; Prepost, R; Pripstein, M; Prudent, X; Pruvot, S; Pulliam, T; Purohit, M V; Pérez, A; Rahatlou, S; Rahimi, A M; Rahmat, R; Rama, M; Ratcliff, B N; Raven, G; Regensburger, J J; Renga, F; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roberts, D A; Robertson, A I; Robertson, S H; Robutti, E; Rodier, S; Roe, N A; Ronan, M T; Roney, J M; Roodman, A; Rosenberg, E I; Rotondo, M; Roudeau, P; Rubin, A E; Ruland, A M; Röthel, W; Sacco, R; Saeed, M A; Saleem, M; Salnikov, A A; Salvati, E; Salvatore, F; Sanders, D A; Santoro, V; Santroni, A; Saremi, S; Schalk, T; Schenk, S; Schilling, C J; Schindler, R H; Schofield, K C; Schott, G; Schröder, T; Schröder, H; Schubert, J; Schubert, K R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Serrano, J; Sharma, V; Shen, B C; Simard, M; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Yu I; Smith, A J S; Smith, J G; Snoek, H L; Snyder, A; Sobie, R J; Soffer, A; Sokoloff, M D; Solodov, E P; Sordini, V; Spaan, B; Spanier, S M; Spitznagel, M; Steinke, M; Stelzer, J; Stocchi, A; Stoker, D P; Stroili, R; Strom, D; Strube, J; Stugu, B; Su, D; Sullivan, M K; Summers, D J; Sun, L; Sundermann, J E; Suzuki, K; Swain, S K; Tackmann, K; Taras, P; Taylor, F; Telnov, A V; Teodorescu, L; Ter-Antonian, R; Thiebaux, C; Thompson, J M; Tisserand, V; Todyshev, K Yu; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Tuggle, J M; Ulmer, K A; Uwer, U; Van Bakel, N; Vasseur, G; Vavra, J; Verderi, M; Viaud, F B; Vitale, L; Voci, C; Voena, C; Volk, A; Wacker, K; Wagner, A P; Wagner, S R; Waldi, R; Walker, D; Walsh, J J; Wang, W F; Wappler, F R; Watson, A T; Weaver, M; Wenzel, W A; West, T J; Wilden, L; Williams, D C; Wilson, F F; Wilson, J R; Wilson, M G; Wilson, R J; Winklmeier, F; Winstrom, L O; Wisniewski, W J; Wittgen, M; Wong, Q K; Wormser, G; Wren, A C; Wright, D H; Wright, D M; Wu, J; Wu, S L; Xie, Y; Yamamoto, R K; Yarritu, A K; Ye, S; Yi, J I; Yi, K; Young, C C; Yu, Z; Yéche, C; Zain, S B; Zallo, A; Zeng, Q; Zghiche, A; Zhang, J; Zhang, L; Zhao, H W; Ziegler, V; Zito, M; Çuhadar-Dönszelmann, T; al, et

    2007-01-01

    We determine the relative branching fractions of semileptonic B decays to charmed final states. The measurement is performed on the recoil from a fully reconstructed B meson in a sample of 362 million BBbar pairs collected at the Upsilon(4S) resonance with the BaBar detector. A simultaneous fit to a set of discriminating variables is performed on a sample of Bbar --> D X l^- anti-nu_l decays to determine the contributions from the different channels. We measure Gamma(B- --> D l^- anti-nu_l)/Gamma (B- --> D X l^- anti-nu_l)= 0.227 +/- 0.014 +/- 0.016, Gamma(B- --> D* l^- anti-nu_l)/Gamma (B- --> D X l^- anti-nu_l)= 0.582 +/- 0.018 +/- 0.030 and Gamma(B- --> D** l^- anti-nu_l)/Gamma (B- --> D X l^- anti-nu_l)= 0.191 +/- 0.013 +/- 0.019 for the charged B sample, and Gamma(B0bar --> D l^- anti-nu_l)/Gamma (B0bar --> D X l^- anti-nu_l)= 0.215 +/- 0.016 +/- 0.013, Gamma(B0bar --> D* l^- anti-nu_l)/Gamma (B0bar --> D X l^- anti-nu_l)= 0.537 +/- 0.031 +/- 0.036 and Gamma(B0bar --> D** l^- anti-nu_l)/Gamma (B0bar --> ...

  12. Usefulness and limitation of DDD and PDD analyses. 12 months of solid oral antipsychotics prescribing data for the NHS-reimbursed treatment of schizophrenia in Italy

    Directory of Open Access Journals (Sweden)

    Lorenzo Pradelli

    2008-12-01

    Full Text Available The estimation of real-world pharmaceutical costs in a given setting is one of the crucial steps in pharmacoeconomic comparisons among drugs used in that setting. For the purpose of this estimation, information regarding available pharmaceutical forms, alongside price and market share, for every considered drug is needed. Furthermore, it’s necessary to know, at least approximately, drug quantities averagely consumed in each episode, in the case of acute therapies, or on a daily basis in chronic therapies. This data is difficult to measure in non-experimental settings, and is generally approximated using the statistical average of the drug quantity prescribed by physicians for a given condition. This paper will briefly review definitions and appropriate uses of DDDs (defined daily dose, and PDDs (prescribed daily dose, and then illustrate the expressed concepts on the basis of a practical example constructed on the analysis of last available 12 months of solid oral antipsychotics prescribing data for the NHS-reimbursed treatment of schizophrenia in Italy.

  13. Hexachlorocyclohexanes and DDT, DDE, and DDD isomer Residues in Eggs of Killdeer (Charadrius vociferous) at Sites 10B and 9, Nevada

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report provides an analysis of potential ecological effects on killdeer reproduction and viability at a nesting site in southern Nevada. Data were in the form...

  14. DDD (diseño dirigido por el dominio) y aplicaciones Enterprise: ¿fidelidad al modelo o a las herramientas?

    OpenAIRE

    Echeverría, Adriana; López, Gustavo; Grossi, María Delia; Servetto, Arturo; Jeder, Ismael; Paredes, Adrián; Linares, Pablo

    2010-01-01

    Teniendo como marco de trabajo la cátedra de “Trabajo Profesional” de la Facultad de Ingeniería de la Universidad de Buenos Aires, se presenta una experiencia de desarrollo, en la que se trató de respetar el conocimiento teórico, el modelo así como también contemplar maneras de resolver la distancia entre lo que puede ofrecer una herramienta de desarrollo que no se ajusta completamente a la teoría o el modelo elegido para construir la aplicación Enterprise correcta. El prototipo desarrolla...

  15. Occurences and Fate of DDT Principal Isomers/Metabolites, DDA, and o,p'-DDD Enantiomers in Fish, Sediment and Water at a DDT-Impacted Superfund Site

    Science.gov (United States)

    In the 1950s and 60s, discharges from a DDT manufacturing plant contaminated a tributary system of the Tennessee River near Huntsville, Alabama, USA. Regulatory action resulted in declaring the area a Superfund site which required remediation and extensive monitoring. Monitoring ...

  16. Genotype data: 4 [

    Lifescience Database Archive (English)

    Full Text Available P30 DDBDDDDBDD-DDD-DBDDBDDDDDDBDBDDDDDBBDBDDDDBBDDBD-DBDDDBDD--BBDDBDDBBBDDDDD--DBBDBDDDDDD-DBDD--DDDDDDBDD...-DBDDBDB-DDDDBDDDBDBDBDDDDDDDDDBDD--BDDD-DDDBD-DDBBDDDBDDDDBD--DBDD-DDD-DDBDBDDDBDD ...

  17. Trends in extreme temperature indices in Huang-Huai-Hai River Basin of China during 1961-2014

    Science.gov (United States)

    Wang, Gang; Yan, Denghua; He, Xiaoyan; Liu, Shaohua; Zhang, Cheng; Xing, Ziqiang; Kan, Guangyuan; Qin, Tianling; Ren, Minglei; Li, Hui

    2017-08-01

    Spatial and temporal characteristics of temperature extremes have been investigated in Huang-Huai-Hai (HHH) region based on the daily series of temperature observations from 162 meteorological stations. A total of 11 indices were used to assess the changes of temperature pattern. Linear trend analyses revealed that the daily maximum temperature (TXx) increased at α = 0.05 level with a magnitude of 0.15 °C per decade on the regional scale during the period of 1961-2014. More pronounced warming trend of the daily minimum temperature (TNn) was detected at a rate of 0.49 °C per decade (α = 0.01 level). Consequently, a decreasing trend of the temperature range of TXx and TNn (extreme temperature range) was observed. The frequency of hot days (TXf90) and annual average of warm events (warm spell duration indicator, WSDI) showed significant increasing trends, while that of cold nights (TNf10) and cold events (cold spell duration indicator, CSDI) showed opposite behaviors. Both warm winter (W-W) and hot summer (H-S) series displayed significant increasing trends at α = 0.01 confidence level. The cold winter (C-W) series showed a decreasing trend at α = 0.01 confidence level, while the cool summer (C-S) series showed a nonsignificant decreasing trend that is not passing the 90% confidence level (α = 0.1). Abrupt increments of warm­related extremes (TXx, TXf90, WSDI) have been detected since 1990s, and a steadily decreasing trend of cold related extremes (TNf10, CSDI) was found since 1970s. Ten hot summers out of 11 and nine warm winters out of 10 occurred after 1990s. Altitude has a large impact on spatial pattern of extreme temperature indices, and the urban heat island effect also has an impact on amplitude of variation in extreme temperature. Trend magnitudes are significantly larger at sites with high altitudes for warm­related indices (TXx, TXf90, WSDI), while those involving cold-related indices (TNn, TNf10) are remarkably larger for stations with low

  18. 出口食品农产品检验检疫风险评价体系的建立%The Establishment of Risk Assessment System for Inspection and Quarantine of Food and Agricultural Exports

    Institute of Scientific and Technical Information of China (English)

    陈孟裕; 高保立; 毛唯君; 梁启平; 翁志平

    2011-01-01

    The Inspection and Quarantine Risk Assessment Matrix(IQRAM) for export food and agricultural products were constructed with the principles and methods of U.S.MIL-STD-822B standard.For the first time,the Inspection and Quarantine Risk Accident(IQRA) was defined as the adverse reactions caused by substandard product at home or abroad.The IQRA severe grading standards were established,and the probability of IQRA was estimated by the frequency of the IQRA occurring within a year in the paper.The monitoring program of food and agricultural exports was developed with 459 batches of samples,according to EU Directive 2002/63/EC.Based on risk evaluation system,the risk of inspection and quarantine of export food and agricultural products is set to five levels,such as HHH,HH,H,M and L.The specific risk level of exported companies or products could be dynamically adjusted to tightening or loosening according to the monitoring results.%利用美国M IL-STD-822B标准的原理和方法构建了出口食品农产品检验检疫风险评价矩阵,首次定义了检验检疫风险事故是不合格产品引起的国内外不良反应,并制定了风险事故后果的严重等级划分标准,确立了以一年内发生风险事故的频次作为风险事故发生概率的原则;同时依据欧盟2002/63/EC指令对风险评价结果制定了以连续459批为一个监控周期的抽样方案。根据风险评价体系,将出口食品农产品检验检疫风险设置为5个风险等级:HHH、HH、H、M和L,依据监控抽样的检测结果可以对具体出口企业和产品进行风险等级加严或放宽的动态调节。

  19. Oxygen isotope and petrological study of silicate inclusions in IIE iron meteorites and their relationship with H chondrites

    Science.gov (United States)

    McDermott, Kathryn H.; Greenwood, Richard C.; Scott, Edward R. D.; Franchi, Ian A.; Anand, Mahesh

    2016-01-01

    The origin of silicate-bearing irons, especially those in groups IAB, IIICD, and IIE, is poorly understood as silicate should have separated rapidly from molten metal. Here we report the results of high precision oxygen isotope analysis of silicate inclusions in eleven group IIE meteorites and a petrological study of silicate inclusions in ten IIE irons including those in Garhi Yasin and Tarahumara, which have not been described in detail before. Oxygen isotopes have also been analysed in 20 H chondrites to investigate their possible relationship with the IIE irons. Based on petrographic observations and mineral analysis, the silicate-bearing IIE meteorites have been divided into four types according to the nature of their silicate inclusions: (1) primitive chondritic, (2) evolved chondritic, (3) differentiated with >10 vol.% orthopyroxene, and (4) differentiated with source for Colomera is deemed unlikely. Three IIE irons with primitive chondritic inclusions, Garhi Yasin, Netschaëvo, and Techado, have relatively low mean Δ17O values of 0.56-0.57‰ as well as relatively reduced silicates with Fa15-17 olivine, which have been called HH chondrites. Given the significant overlap in their oxygen isotope compositions, a genetic relationship between IIE irons and H chondrites is supported by our new data. However, derivation of both groups from one parent body seems unlikely. Instead, both groups probably sampled similar precursor materials and accreted at a similar nebular location. Our data suggest that the IIE meteorites formed on an internally heated H/HH chondrite-like body that experienced the initial stages of differentiation in response to radiogenic heating. However, prior to full differentiation the IIE parent body experienced a major hit-and-run style collision that resulted in silicate-metal mixing. The initial stages of this event involved a phase of rapid cooling that prevented unmixing of metal and silicates. Reassembly of the IIE parent body produced a

  20. Rehabilitating nursing of DDD pacemaker installation for patients with serious arrhythmia accompanied by heart failure%重症心律失常并心力衰竭安置DDD起搏器的康复治疗护理

    Institute of Scientific and Technical Information of China (English)

    向岚

    2000-01-01

    目的为了配合安置DDD起搏器手术的顺利进行,探讨一系列完整的护理措施,总结DDD在治疗心力衰竭方面的疗效.方法对28例安置DDD起搏器患者进行术前、术后护理,15例安置DDD起搏器治疗心律失常并心力衰竭的患者进行疗效观察.结果通过加强护理及配合康复治疗,无一例术后护理并发症发生,15例心力衰竭患者12例心功能明显好转,其中6例可自理生活.结论生理性起搏器可保证心房的收缩及房室的顺序收缩,从而增强心输出量,改善心功能,纠正心衰.同时手术的术前、术后护理及康复治疗对术后促进患者康复、杜绝术后并发症起到了重要作用.

  1. Effects of amendments on soil availability and phytoremediation potential of aged p,p'-DDT, p,p'-DDE and p,p'-DDD residues by willow plants (Salix sp.).

    Science.gov (United States)

    Mitton, Francesca M; Gonzalez, Mariana; Peña, Aránzazu; Miglioranza, Karina S B

    2012-02-15

    Combining technologies offer a great potential to phytoremediate contaminated soils. As sequestration occurs, pollutants availability decline and organic amendments could counterbalance that situation. This work studies the potential of willow plants to phytoremediate soil containing p,p'-DDT (101.3 ng g(-1)) and p,p'-DDE (381.4 ng g(-1)) residues. The effect of root exudates, Tween 80 and citric and oxalic acids on DDTs desorption and availability from soil was tested together with the plant uptake and translocation. Treatments increased the p,p'-DDE/p,p'-DDT ratio when compared with control (water) soil. Watering with carboxylic acids led to a significant enhancement of the quantities of p,p'-DDT and p,p'-DDE desorbed from soil that was related with an increase of organic carbon in solution. Willow plants accumulated DDTs under all treatments although plants watered with carboxylic acids showed the highest leaves translocation factor for both p,p'-DDT and p,p'-DDE. Results indicate that the addition of carboxylic acids enhanced DDTs bioavailability which further increases plant uptake and translocation. The effect of surfactants on the soil-plant systems needs to be better assessed for this particular soil and plant species. The enhancement of soluble organic carbon is crucial at the moment of evaluating DDTs release from soil as well as to establish cleaning strategies.

  2. DDD起搏器选择心室起搏部位对血流动力学的影响%Effects of ventricular pacing ways on hemodynamics in patients with implanted DDD pacemakers

    Institute of Scientific and Technical Information of China (English)

    洪鹭蓉; 吴少平; 黄小洪; 郑桂安

    2007-01-01

    目的 比较右室间隔部(RVS)和右室心尖部(RVA)起搏对血流动力学的影响.方法 42例置入DDD起搏器的患者,分为RVS组和RVA组;比较2组术前和术后3个月随访的左室射血分数(LVEF)、心脏指数(CI)、每搏量(SV)、左室最大压力上升速率(dp/dt max)、左室最大压力下降速率(-dp/dt max)、二尖瓣血流E峰和A峰最大充盈速度比值(E/A)、等容舒张时间(IVRT)差异.结果 与术前相比,RVA组3个月随访的LVEF、CI、SV、dp/dt max、-dp/dt max、E/A、IVRT均显著降低(0.51±0.04 vs 0.54±0.03;2.33±0.09 L/min·m-2 vs 2.68±0.11 L/min·m-2;71.11±14.2 ml vs 80.17±16.12 ml;1 614±133 mmHg/s vs 1 702±155 mmHg/s;2 230±234mmHg/s vs 2 404±242 mmHg/s;1.38±0.47 vs 1.86±0.28;73.2±3.86 ms vs 77.6±4.15 ms,均P<0.05),RVS组无明显变化.3个月随访RVS组LVEF、CISV、SV、dp/dt max均显著高于RVA组(P<0.05).结论 RVS起搏对血流动力学无不良影响.

  3. 40 CFR 129.4 - Toxic pollutants.

    Science.gov (United States)

    2010-07-01

    ...-dimethanonaphthalene. (b) DDT—DDT means the compounds DDT, DDD, and DDE as identified by the chemical names:(DDT)-1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane and someo,p′-isomers; (DDD) or...

  4. Genotype data: 6 [

    Lifescience Database Archive (English)

    Full Text Available P7 BDBBDDDDDB-DDD-DDDDDBDDBBBDBDDD-BDDBDDBDDDDBDDDDDBDDDDBDDDBDDBDDDDBDDD-DBD-DDDDDBDBDDDBDDDBDDBDDBDDDBDD...-DDDBBBBDDBDDBDDBD-BDDBBBDBDBDBBDD--DDDB-BBBDD-DBDBBDDDDBDDDDBDDDDD-DDBDDDBDDDDDDDD ...

  5. 40 CFR 63.2535 - What compliance options do I have if part of my plant is subject to both this subpart and another...

    Science.gov (United States)

    2010-07-01

    ... stringency determinations. (h) Compliance with 40 CFR part 60, subpart DDD, III, NNN, or RRR. After the... provisions of this subpart that are also subject to the provisions of 40 CFR part 60, subpart DDD, III, NNN... to a standard in 40 CFR part 60, subpart DDD, III, NNN, or RRR, you may elect to comply with...

  6. Developmentally Disabled Persons in Family Settings: Report No. 3.

    Science.gov (United States)

    Cox, Wendy M.; Wilson, Wendell L.

    The final part of a three part study of developmentally disabled persons in Washington State, this document focuses on clients of the Division of Developmental Disabilities (DDD), ages 19 through 26, who appeared to be eligible for DDD services but were not enrolled with the DDD (group C). Telephone interviews were conducted with parents of 55…

  7. Developmentally Disabled Persons in Family Settings: Report No. 2.

    Science.gov (United States)

    Cox, Wendy M.; Wilson, Wendell L.

    The second in a series of three reports, this document presents findings of clients of Washington's Division of Developmental Disabilities (DDD), ages 22-29, who were living with their families at age 18 but now live elsewhere (group B). Findings are based on telephone interviews with families of 224 DDD clients and analysis of DDD records. The…

  8. Innovations in tourism marketing: Operation Anthropoid in Prague

    Directory of Open Access Journals (Sweden)

    W. Strielkowski

    2016-12-01

    Operation Daybreak” or from the book “HHhH” by the French writer and historian Laurent Binet. Moreover, our results show that the potential smartphone and tablet app should contain an opening introductory video about the Operation Anthropoid, an interactive map, facts & details augmented reality photos, a quest with a possibility to collect points or play against other users, as well as the information on the Prague transportation and the possibility to buy tickets online. The app should be offered free of charge, as a so-called “light version” with a possibility to buy the full version, or should be offered for free download at App Store or Google Market with an option to send a donation to its creators. Conclusions and directions for further research. Our results might lead to the successful creation and implementation of the geolocation game which became very popular recently due to the breath-taking success of the “Pokemon Go” game worldwide. As for the pathways for further research, an analysis of attributes and other features of potential app might be also tested using a conjoint analysis approach or revealed preferences techniques. Some more research can be done on eliciting the willingness-to-pay (WTP for the potential app-like game.

  9. 抗心房颤动起搏器和普通DDD起搏器治疗阵发性心房颤动的疗效对比%Contrast of the efficacy in the treatment of paroxysmal atrial fibrillation between anti-atrial fibrillation pacemaker and conventional DDD pacemaker

    Institute of Scientific and Technical Information of China (English)

    刘红明; 郭涛; 赵玲

    2006-01-01

    目的 对比抗心房颤动(简称房颤)起搏器和普通DDD起搏器治疗阵发房颤的疗效.方法 阵发房颤患者19例置入Vitatron型或ST.JudeAFX抗房颤起搏器,21例置入普通DDD起搏器.结果 两组生活质量评分提高分别达35分(P<0.05)和43分(P<0.05),显效率分别为47.4%和14.3%(P<0.05)、有效率分别为73.7%和23.8%(P<0.05).900E患者房颤负荷降低58.57%(P<0.05).结论 抗房颤起搏器治疗阵发房颤优于普通DDD起搏器,似可作为传统治疗方法的重要补充.

  10. 抗房颤起搏器和普通DDD起搏器治疗阵发房颤的疗效对比%Comparison of the efficacies between anti-atrial fibrillation pacemaker and conventional DDD pacemaker in the treatment of paroxysmal atrial fibrillation.

    Institute of Scientific and Technical Information of China (English)

    刘红明; 郭涛; 赵玲

    2006-01-01

    目的 对比抗心房颤动(简称房颤)起搏器和普通DDD起搏器治疗阵发房颤的疗效.方法 阵发房颤患者19例植入Vitatron型或ST.JudeAFX抗房颤起搏器,21例植入普通DDD起搏器.结果 两组生活质量评分提高分别达63.11%(P<0.05),显效率分别为47.4%和14.3%(P<0.05),有效率分别为73.7%和23.8%(P<0.05).900E患者房颤负荷降低程度达58.57%(P<0.05).结论 抗房颤起搏器治疗阵发房颤优于普通DDD起搏器,可作为传统治疗方法的重要补充.

  11. AAI、DDD起搏方式对病窦综合征患者血流动力学及神经内分泌因子的影响%Effect of Pacing Mode (AAI vs DDD) on Hemodynamic and Neuroendocrine in Patients with Sick Sinus Syndrome

    Institute of Scientific and Technical Information of China (English)

    张莹莹; 许静; 付乃宽; 卢凤民; 吴冬燕

    2010-01-01

    目的:探讨AAI与DDD起搏方式对病窦综合征(SSS)患者血流动力学及神经内分泌因子的影响.方法:20例因SSS入院并植入双腔起搏器的患者,先以DDD方式起搏1周,再以AAI方式起搏1周.记录不同起搏方式下QRS波宽度、起搏方式调整即刻血流动力学的变化,并检测不同起搏方式起搏1周后神经内分泌因子的变化.结果:(1)DDD模式下QRS波较AAI模式下增宽,差异有统计学意义(P<0.05).(2)主动脉血流速度时间积分(AVTI)在DDD模式下较AAI模式下降低,差异有统计学意义(P<0.01).(3)与AAI模式相比DDD模式造成神经内分泌因子心钠素(ANP)、内皮素(ET)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)升高,差异有统计学意义(P<0.05或P<0.01).结论:与AAI起搏方式相比DDD起搏方式短期即可造成神经内分泌激活,并影响左室功能.

  12. MR imaging of degenerative disc disease

    Energy Technology Data Exchange (ETDEWEB)

    Farshad-Amacker, Nadja A., E-mail: nadja.farshad@usz.ch [Institute of Diagnostic and Interventional Radiology, University Hospital of Zurich, Zurich (Switzerland); Farshad, Mazda [Department of Orthopaedic Surgery, Balgrist University Hospital, Zurich (Switzerland); Winklehner, Anna; Andreisek, Gustav [Institute of Diagnostic and Interventional Radiology, University Hospital of Zurich, Zurich (Switzerland)

    2015-09-15

    Highlights: • This systematic literature review summarizes the current knowledge on MR imaging in degenerative disc disease. • Different classification systems for segmental spine degeneration are summarized. • It outlines the diagnostic limitations of MR imaging. - Abstract: Magnet resonance imaging (MRI) is the most commonly used imaging modality for diagnosis of degenerative disc disease (DDD). Lack of precise observations and documentation of aspects within the complex entity of DDD might partially be the cause of poor correlation of radiographic findings to clinical symptoms. This literature review summarizes the current knowledge on MRI in DDD and outlines the diagnostic limitations. The review further sensitizes the reader toward awareness of potentially untended aspects of DDD and the interaction of DDD and endplate changes. A summary of the available classifications for DDD is provided.

  13. Impact of pacing modality and biventricular pacing on cardiac output and coronary conduit flow in the post-cardiotomy patient.

    LENUS (Irish Health Repository)

    Healy, David G

    2012-02-03

    We have previously demonstrated the role of univentricular pacing modalities in influencing coronary conduit flow in the immediate post-operative period in the cardiac surgery patient. We wanted to determine the mechanism of this improved coronary conduit and, in addition, to explore the possible benefits with biventricular pacing. Sixteen patients undergoing first time elective coronary artery bypass grafting who required pacing following surgery were recruited. Comparison of cardiac output and coronary conduit flow was performed between VVI and DDD pacing with a single right ventricular lead and biventricular pacing lead placement. Cardiac output was measured using arterial pulse waveform analysis while conduit flow was measured using ultrasonic transit time methodology. Cardiac output was greatest with DDD pacing using right ventricular lead placement only [DDD-univentricular 5.42 l (0.7), DDD-biventricular 5.33 l (0.8), VVI-univentricular 4.71 l (0.8), VVI-biventricular 4.68 l (0.6)]. DDD-univentricular pacing was significantly better than VVI-univentricular (P=0.023) and VVI-biventricular pacing (P=0.001) but there was no significant advantage to DDD-biventricular pacing (P=0.45). In relation to coronary conduit flow, DDD pacing again had the highest flow [DDD-univentricular 55 ml\\/min (24), DDD-biventricular 52 ml\\/min (25), VVI-univentricular 47 ml\\/min (23), VVI-biventricular 50 ml\\/min (26)]. DDD-univentricular pacing was significantly better than VVI-univentricular (P=0.006) pacing but not significantly different to VVI-biventricular pacing (P=0.109) or DDD-biventricular pacing (P=0.171). Pacing with a DDD modality offers the optimal coronary conduit flow by maximising cardiac output. Biventricular lead placement offered no significant benefit to coronary conduit flow or cardiac output.

  14. Genotype data: 4 [

    Lifescience Database Archive (English)

    Full Text Available P16 DDBDDDDBDD-DDDBDBDDBDDDDDD-DDDDDDDBBDBDDDDDBDDBDDDDDDDB-DDBB-DDBD-BB-DD-DD-BDBBDBDDDDDDDDBDDBD-DDDDDBDD...-D-DDBD-DDDDDBDDDBDBD-DDDBD-DDDBDD---DDD-DDDBD-DDBBDBDBDDDDBDDBDBDD-DDDDDDBDBDDDBDD ...

  15. Genotype data: 10 [

    Lifescience Database Archive (English)

    Full Text Available P14 DBDDDDBDDD-DDBDDDBDBDDBBBDDDDBBDDD-BBDDDDBDBBDBBBDDDBDDBDDDDDDBBDDBDDBDDDB-DDBD-BDBBDDBBDDB-BDDBDD...DDDDD-B-BD--DDD-DBDBBDD-DDDDDDDDDDDDDDB--DD-B-DBBD--DDDBDDDBDDDBDDBDDBDB--D-DBDBDBDBBBD- ...

  16. Vertebral degenerative disc disease severity evaluation using random forest classification

    Science.gov (United States)

    Munoz, Hector E.; Yao, Jianhua; Burns, Joseph E.; Pham, Yasuyuki; Stieger, James; Summers, Ronald M.

    2014-03-01

    Degenerative disc disease (DDD) develops in the spine as vertebral discs degenerate and osseous excrescences or outgrowths naturally form to restabilize unstable segments of the spine. These osseous excrescences, or osteophytes, may progress or stabilize in size as the spine reaches a new equilibrium point. We have previously created a CAD system that detects DDD. This paper presents a new system to determine the severity of DDD of individual vertebral levels. This will be useful to monitor the progress of developing DDD, as rapid growth may indicate that there is a greater stabilization problem that should be addressed. The existing DDD CAD system extracts the spine from CT images and segments the cortical shell of individual levels with a dual-surface model. The cortical shell is unwrapped, and is analyzed to detect the hyperdense regions of DDD. Three radiologists scored the severity of DDD of each disc space of 46 CT scans. Radiologists' scores and features generated from CAD detections were used to train a random forest classifier. The classifier then assessed the severity of DDD at each vertebral disc level. The agreement between the computer severity score and the average radiologist's score had a quadratic weighted Cohen's kappa of 0.64.

  17. L. Sumera: Symphony No. 5 / Michael Scott Rohan

    Index Scriptorium Estoniae

    Rohan, Michael Scott

    1997-01-01

    L. Sumera: Symphony No. 5; Music for Chamber Orchestra, In memorian. Malmö Symphony Orchestra / Paavo Järvi. BIS CD-770. 64-35 DDD; Various. Searching for Roots - music from Estonia. Virgin VC 5 43242 2; 71: 34 DDD

  18. Assessment of Pesticide Residues in Tomatoes and Watermelons ...

    African Journals Online (AJOL)

    ADOWIE PERE

    info and ... DDD, o,p'-DDD, p,p'-DDE and α-HCH with highest concentrations varying from 1 ± 0.5 to 20 ± ... https://dx.doi.org/10.4314/jasem.v21i3.10 ... limits may pose health hazards to the consumers ..... Food Science and Technology Letters.

  19. 78 FR 24426 - Orthopaedic and Rehabilitation Devices Panel of the Medical Devices Advisory Committee; Notice of...

    Science.gov (United States)

    2013-04-25

    ... lumbar degenerative disc disease (DDD) where DDD is defined as discogenic back pain with degeneration of... information related to the premarket approval application for the Kineflex Lumbar Artificial Disc sponsored by SpinalMotion. The Kineflex Lumbar Artificial Disc is a metal-on-metal (cobalt chrome molybdenum...

  20. Differentiation of adipose stem cells by nucleus pulposus cells: Configuration effect

    NARCIS (Netherlands)

    Lu, Z.F.; Zandieh Doulabi, B.; Wuisman, P.I.; Bank, R.A.; Helder, M.N.

    2007-01-01

    Degenerative disc disease (DDD) is a major cause of chronic low back pain. For mild/intermediate DDD, regeneration by injecting adipose stem cells (ASCs) into the nucleus pulposus (NP) may be considered. The goal of this study is to investigate whether NP cells can direct ASCs towards the NP phenoty

  1. Microstructurally Based Cross-slip Mechanisms and Their Effects on Dislocation Microstructure Evolution in fcc Crystals

    Science.gov (United States)

    2015-01-01

    Annu. Rev. Mater. Res. 39 (1) (2009) 361–386. [69] J.R. Greer, J.Th.M. De Hosson, Plasticity in small-sized metallic systems: Intrinsic versus extrinsic ...incorporated into DDD simulations. Accordingly, the motivation of the current work is to incorporate an atomistically informed cross-slip model into DDD

  2. L. Sumera: Symphony No. 5 / Michael Scott Rohan

    Index Scriptorium Estoniae

    Rohan, Michael Scott

    1997-01-01

    L. Sumera: Symphony No. 5; Music for Chamber Orchestra, In memorian. Malmö Symphony Orchestra / Paavo Järvi. BIS CD-770. 64-35 DDD; Various. Searching for Roots - music from Estonia. Virgin VC 5 43242 2; 71: 34 DDD

  3. Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas

    DEFF Research Database (Denmark)

    Shen, Heqing; Virtanen, H E; Main, Katharina M

    2006-01-01

    The enantiomeric ratios (ER) of alpha-HCH and o,p'-DDT ((+)-isomer concentration/(-)-isomer concentration) and o,p'-DDD (first eluting enantiomer/second enantiomer) were investigated in 112 human placentas from Finnish boys collected 1997-2001. Both o,p'-DDD and alpha-HCH showed changes in their ER...

  4. Early Intervention of Didang Decoction on MLCK Signaling Pathways in Vascular Endothelial Cells of Type 2 Diabetic Rats

    Directory of Open Access Journals (Sweden)

    Shoujiao Ye

    2016-01-01

    Full Text Available In the study, type 2 diabetic rat model was established using streptozotocin (STZ combined with a high-fat diet, and the rats were divided into control and diabetic groups. Diabetic groups were further divided into nonintervening, simvastatin, Didang Decoction (DDD early-phase intervening, DDD mid-phase intervening, and DDD late-phase intervening groups. The expression level of MLCK was detected using Western Blot analysis, and the levels of cyclic adenosine monophosphate (cAMP, protein kinase C (PKC, and protein kinase A (PKA were examined using Real Time PCR. Under the electron microscope, the cells in the early-DDD-intervention group and the simvastatin group were significantly more continuous and compact than those in the diabetic group. Compared with the control group, the expression of cAMP-1 and PKA was decreased in all diabetic groups, whereas the expression of MLCK and PKC was increased in early- and mid-phase DDD-intervening groups (P<0.05; compared with the late-phase DDD-intervening group, the expression of cAMP-1 and PKA was higher, but the level of MLCK and PKC was lower in early-phase DDD-intervening group (P<0.05. In conclusion, the early use of DDD improves the permeability of vascular endothelial cells by regulating the MLCK signaling pathway.

  5. Analgetikaforbrug, -overdosering og -dødsfald i Danmark 1979-1986

    DEFF Research Database (Denmark)

    Ott, P; Hansen, P B; Dalhoff, K P

    1990-01-01

    During 1978-1987 the annual sale of analgetics increased by 28% to 164 millions defined daily doses (mDDD) per year. Paracetamol changed status to over-the-counter drug by 1.1.1984 as did combinations of acetylicsalicylic acid and codein 14.5.1984. The consumption of paracetamol increased rapidly...... to 47 mDDD/-year, the mortality steadily decreasing to 0.07 deaths/mDDD in 1986. The consumption of salicylics decreased from 113 to 94 mDDD, of which the salicylic/codein combination constituted an increasing fraction. The mortality of salicylics increased from 0.05 death/mDDD in 1983 to 0.27/m...

  6. Correlation between prescribed daily dose, seizure freedom and defined daily dose in antiepileptic drug treatment.

    Science.gov (United States)

    Horváth, László; Fekete, Klára; Márton, Sándor; Fekete, István

    2017-04-01

    Background Although defined daily doses (DDD) for antiepileptic drugs (AED) have been assigned only in combination therapy, based on the literature, most patients take them in monotherapy. Furthermore, discrepancies between DDD and prescribed daily dose (PDD) were observed. Objective First, to determine PDDs of AEDs and to reveal PDD/DDD ratio among seizure free versus not seizure free patients in everyday clinical practice. Second, to test the applicability of 75% cut-off of DDD to achieve seizure freedom. Furthermore, to find out what factors might influence PDD. Setting Outpatient data files at a Hungarian university hospital were studied. Methods A retrospective, 20-year cross-sectional database was compiled from 1282 epileptic outpatients' files. Main outcome measure Seizure freedom and PDD were used as outcome measures. Results The mean DDD% of all prescribed AEDs increased steadily from monotherapy, through bitherapy towards polytherapy (p seizure free patients took AEDs in doses in the range of ≤75% of DDDs in monotherapy and bitherapy. Older AEDs (carbamazepine and valproate) were given in a significantly higher mean dose in bitherapy in the seizure free group. Among the newer types, only levetiracetam and lamotrigine had a significantly higher DDD% in mono-, bi-, and polytherapy. Confirmed by logistic regression analysis, gender, age, type of epilepsy, and number of AEDs had a significant impact on the value of 75% DDD. Conclusion No significant unfavourable impact of the lower ratio of PDD/DDD on the outcome of achieving seizure freedom has been confirmed. As a measure of seizure freedom, 75% of DDD may be used, although individual therapy must be emphasised. Precisely quantified DDD would provide a more accurate calculation of other derived values.

  7. Использование подхода DDD для построения модели предметной области проекта

    OpenAIRE

    Тюменцева, Кристина Михайловна

    2016-01-01

    Объектом исследования является возможность автоматизации процесса заключения страхового договора и создание приложения для применения в области страхования. Предмет исследования – методологии и подходы к разработке приложения. Цель работы – применение подходов предметно-ориентированного проектирования в рамках которых принимаются проектные решения и формирование единого языка для группы разработки программного обеспечения. В процессе исследования проводились выбор методологии разрабо...

  8. A field assessment of long-term laboratory sediment toxicity tests with the amphipod Hyalella azteca

    Science.gov (United States)

    Ingersoll, Christopher G.; Wang, Ning; Hayward, Jeannie M. R.; Jones, John R.; Jones, Susan B.; Ireland, D. Scott

    2005-01-01

    Response of the amphipod Hyalella azteca exposed to contaminated sediments for 10 to 42 d in laboratory toxicity tests was compared to responses observed in controlled three-month invertebrate colonization exposures conducted in a pond. Sediments evaluated included a sediment spiked with dichlorodiphenyldichloroethane (DDD) or dilutions of a field sediment collected from the Grand Calumet River (GCR) in Indiana (USA) (contaminated with organic compounds and metals). Consistent effects were observed at the highest exposure concentrations (400 ??g DDD/goc [DDD concentrations normalized to grams of organic carbon (goc) in sedimentl or 4% GCR sediment) on survival, length, and reproduction of amphipods in the laboratory and on abundance of invertebrates colonizing sediments in the field. Effect concentrations for DDD observed for 10-d length and 42-d reproduction of amphipods (e.g., chronic value [ChV] of 66 ??g DDD/goc and 25% inhibition concentration [IC25] of 68 ??g DDD/goc for reproduction) were similar to the lowest effect concentrations for DDD measured on invertebrates colonizing sediment the field. Effect concentrations for GCR sediment on 28-d survival and length and 42-d reproduction and length of amphipods (i.e., ChVs of 0.20-0.66% GCR sediment) provided more conservative effect concentrations compared to 10-d survival or length of amphipods in the laboratory or the response of invertebrates colonizing sediment in the field (e.g., ChVs of 2.2% GCR sediment). Results of this study indicate that use of chronic laboratory toxicity tests with H. azteca and benthic colonization studies should be used to provide conservative estimates of impacts on benthic communities exposed to contaminated sediments. Bioaccumulation of DDD by oligochaetes colonizing the DDD-spiked sediment was similar to results of laboratory sediment tests previously conducted with the oligochaete Lumbriculus variegates, confirming that laboratory exposures can be used to estimate

  9. A Comparison of Magnetic Resonance Imaging Muscle Fat Content in the Lumbar Paraspinal Muscles with Patient-Reported Outcome Measures in Patients with Lumbar Degenerative Disk Disease and Focal Disk Prolapse

    Science.gov (United States)

    Bhadresha, Ashwin; Lawrence, Owen John; McCarthy, Michael J. H.

    2016-01-01

    Study Design Retrospective study. Objectives To assess the fatty atrophy of the lumbar paraspinal muscles (LPMs) as determined using magnetic resonance imaging in patients with lumbar degenerative disk disease (DDD) and focal disk herniation and to determine if fatty atrophy is associated with patient-reported outcome measures (PROMS). Methods One hundred sixty-five patients with lumbar DDD were identified from a PROMS database of >1,500 patients. These patients were divided into two study groups: DDD alone (n = 58) and DDD with disk herniation (n = 107). A grid was randomly applied to the axial scans at the L3–L4, L4–L5, and L5–S1 levels. The muscle-to-fat ratio of the LPMs was recorded and compared with PROMS data. Subcutaneous fat thickness at each level was also measured. Results This study found no difference in the muscle-to-fat ratio between the DDD and disk herniation groups. There was no association between the muscle-to-fat ratio and PROMS data in either group. There was significantly more subcutaneous fat at all levels in the DDD group as compared with the disk prolapse group. In DDD and disk prolapses, subcutaneous fat was thicker in women (p = 0.013 and 0.001). In patients with DDD, more subcutaneous fat was associated with disability (p Muscle content of erector spinae and multifidus negatively correlated with increasing age in both groups at the L3–L4 level. Conclusions Muscle fat content in the LPM does not appear to relate to PROMS. Muscle content decreases with age. Those with low back pain (DDD) have greater subcutaneous fat thickness. PMID:27190744

  10. The impact of emergency birth control on teen pregnancy and STIs.

    Science.gov (United States)

    Girma, Sourafel; Paton, David

    2011-03-01

    We use panel data from local authorities in England between 1998 and 2004 to examine the differential impact of increased access for teenagers to emergency birth control (EBC) at pharmacies on teenage pregnancies and sexually transmitted infections (STIs). We estimate both difference-in-difference (DD) and the more robust difference-in-difference-in-differences (DDD) models. The DD estimates provide some evidence that pharmacy EBC schemes are associated with higher teenage conception rates, but this result is not upheld in the DDD models. In contrast both the DD and DDD models provide consistent evidence that pharmacy EBC schemes are associated with higher teenage STI rates.

  11. Chopin: Concerto for piano and orchestra No. 2 in F minor / Christopher Headington

    Index Scriptorium Estoniae

    Headington, Christopher

    1992-01-01

    Uuest heliplaadist "Chopin: Concerto for piano and orchestra No. 2 in F minor, Op. 21; Schumann: Concerto for piano and orchestra in A minor Op. 54. Philharmonia Orchestra, Neeme Järvi". Chandos CHAN9061 (62 minutes:DDD)

  12. Pärt, Arvo: Litany. Psalom. Trisagion / Robert Cowan

    Index Scriptorium Estoniae

    Cowan, Robert

    1996-01-01

    Uuest heliplaadist "Pärt, Arvo: Litany. Psalom. Trisagion. Hilliard Ensemble, Estonian Philharmonic Chamber Choir, Tallinn Chamber Orchestra, Tõnu Kaljuste; Lithuanian Chamber Orchestra, Saulius Sondeckis" ECM New Series 449 810-4; 449 810-2 (42 minutes: DDD)

  13. Raid, Kaljo: Symphony No. 2, "Stockholm" / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1996-01-01

    Uuest heliplaadist "Raid, Kaljo: Symphony No. 2, "Stockholm"; Tubin, Eduard: Elegy for Strings (arr. Raid). Symphony No. 11 (orch. Raid). Estonian State Symphony Orchestra, Arvo Volmer". Koch International Classics 37291-2 (48 minutes:DDD)

  14. Prognosis of intervertebral disc loss from diagnosis of degenerative disc disease

    Science.gov (United States)

    Li, S.; Lin, A.; Tay, K.; Romano, W.; Osman, Said

    2015-03-01

    Degenerative Disc Disease (DDD) is one of the most common causes of low back pain, and is a major factor in limiting the quality of life of an individual usually as they enter older stages of life, the disc degeneration reduces the shock absorption available which in turn causes pain. Disc loss is one of the central processes in the pathogenesis of DDD. In this study, we investigated whether the image texture features quantified from magnetic resonance imaging (MRI) could be appropriate markers for diagnosis of DDD and prognosis of inter-vertebral disc loss. The main objective is to use simple image based biomarkers to perform prognosis of spinal diseases using non-invasive procedures. Our results from 65 subjects proved the higher success rates of the combination marker compared to the individual markers and in the future, we will extend the study to other spine regions to allow prognosis and diagnosis of DDD for a wider region.

  15. Tormis. 29 estnische Kalenderlieder / Christoph Schlüren

    Index Scriptorium Estoniae

    Schlüren, Christoph

    1997-01-01

    Uuest heliplaadist "Tormis. 29 estnische Kalenderlieder (Martinstag, Katharinentag, Fasching, Schaukellieder), Drei estnische Spiellieder; Estnischer Philarmonischer Kammerchor; Tõnu Kaljuste"; Virgin/EMI CD 545185-2 (WD: 51'54") DDD

  16. Equivalent Plastic Strain Gradient Plasticity with Grain Boundary Hardening and Comparison to Discrete Dislocation Dynamics

    CERN Document Server

    Bayerschen, E; Wulfinghoff, S; Weygand, D; Böhlke, T

    2015-01-01

    The gradient crystal plasticity framework of Wulfinghoff et al. [53] incorporating an equivalent plastic strain and grain boundary yielding, is extended with additional grain boundary hardening. By comparison to averaged results from many discrete dislocation dynamics (DDD) simulations of an aluminum type tricrystal under tensile loading, the new hardening parameter in the continuum model is calibrated. It is shown that although the grain boundaries (GBs) in the discrete simulations are impenetrable, an infinite GB yield strength corresponding to microhard GB conditions, is not applicable in the continuum model. A combination of a finite GB yield strength with an isotropic bulk Voce hardening relation alone also fails to model the plastic strain profiles obtained by DDD. Instead, a finite GB yield strength in combination with GB hardening depending on the equivalent plastic strain at the GBs is shown to give a better agreement to DDD results. The differences in the plastic strain profiles obtained in DDD simu...

  17. Pärt, Arvo: "Summa". Collage sur BACH. Fratres / Patric Wiklacz

    Index Scriptorium Estoniae

    Wiklacz, Patric

    1997-01-01

    Uuest heliplaadist "Pärt, Arvo: "Summa". Collage sur BACH. Fratres. Cantus in Memoriam Benjamin Britten. Summa. Festina Lente. Tabula rasa. Tapiola Sinfonietta / Jean-Jacques Kantorow". BIS-CD-834. 62:30 DDD

  18. Sibelius: Pohjola's Daughter; Night Ride and Sunrise; Four Legends from Kalevala (Lemminkäinen Suite). Gothenburg Symphony Orchestra, Neeme Järvi / Brian Hunt

    Index Scriptorium Estoniae

    Hunt, Brian

    1997-01-01

    Uuest heliplaadist "Sibelius: Pohjola's Daughter; Night Ride and Sunrise; Four Legends from Kalevala (Lemminkäinen Suite). Gothenburg Symphony Orchestra / Neeme Järvi. Deutsche Grammophon 453 426-2; 70:37 DDD

  19. Pärt, Arvo: Seven Magnificat Antiphons / Barry Witherden

    Index Scriptorium Estoniae

    Witherden, Barry

    1996-01-01

    Uuest heliplaadist "Pärt, Arvo: Seven Magnificat Antiphons. Magnificat. Summa; Tormis, Veljo: The Curse Upon Iron. Karelian Destiny. BBC Singers, Bo Holton". Collins Classics 1472-2 (61 minutes: DDD)

  20. Bernstein: Prelude, Fugue and Riffs / Edward Greenfield

    Index Scriptorium Estoniae

    Greenfield, Edward

    1998-01-01

    Uuest heliplaadist "Bernstein: Prelude, Fugue and Riffs. Facsimile. West Side Story - Symphonic Dances. Divertimento. City of Birmingham Symphony Orchestra / Paavo Järvi. Virgin Classics VC5 45295-2 (68 minutes:DDD)

  1. Bernstein: Prelude, Fugue and Riffs / Michel Parouty

    Index Scriptorium Estoniae

    Parouty, Michel

    1998-01-01

    Uuest heliplaadist "Bernstein: Prelude, Fugue and Riffs. Facsimile. West Side Story - Symphonic Dances. Divertimento. City of Birmingham Symphony Orchestra / Paavo Järvi" Virgin Classics VC5 45295-2 (68 minutes:DDD)

  2. Jolivet: Complete Flute Music, Vol. 2 / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1996-01-01

    Uuest heliplaadist "Jolivet: Complete Flute Music, Vol. 2. Kroumata Percussion Ensemble, Tapiola Sinfonietta, Paavo Järvi". BIS CD 739 (64 minutes: DDD). Item marked from CD630 (6/94), CD272, remainder new to UK

  3. Bartok: Concerto for Orchestra Sz 116 / Edward Seckerson

    Index Scriptorium Estoniae

    Seckerson, Edward

    1992-01-01

    Uuest heliplaadist "Bartok: Concerto for Orchestra Sz 116; Enescu: Romanian Rhapsodies Op. 11-No. 1 in A major No. 2 in D major. Royal Scottish Orchestra / Neeme Järvi" Chandos CHAN8947 (66 minutes:DDD)

  4. Schmidt. Sinfonie Nr. 1 E-Dur; Strauss. Vier sinfonische Zwischenspiele aus Intermezzo. Detroit Symphony Orchestra, Neeme Järvi / Helge Grünewald

    Index Scriptorium Estoniae

    Grünewald, Helge

    1996-01-01

    Uuest heliplaadist "Schmidt. Sinfonie Nr. 1 E-Dur; Strauss. Vier sinfonische Zwischenspiele aus Intermezzo. Detroit Symphony Orchestra, Neeme Järvi. Chandos/Koch CD 9357 (WD: 68'20") DDD (WD:114'36")

  5. Pärt, Arvo: "Summa". Collage sur BACH. Fratres / Patric Wiklacz

    Index Scriptorium Estoniae

    Wiklacz, Patric

    1997-01-01

    Uuest heliplaadist "Pärt, Arvo: "Summa". Collage sur BACH. Fratres. Cantus in Memoriam Benjamin Britten. Summa. Festina Lente. Tabula rasa. Tapiola Sinfonietta / Jean-Jacques Kantorow". BIS-CD-834. 62:30 DDD

  6. The Danish Depression Database

    DEFF Research Database (Denmark)

    Videbech, Poul Bror Hemming; Deleuran, Anette

    2016-01-01

    AIM OF DATABASE: The purpose of the Danish Depression Database (DDD) is to monitor and facilitate the improvement of the quality of the treatment of depression in Denmark. Furthermore, the DDD has been designed to facilitate research. STUDY POPULATION: Inpatients as well as outpatients...... as an evaluation of the risk of suicide are measured before and after treatment. Whether psychiatric aftercare has been scheduled for inpatients and the rate of rehospitalization are also registered. DESCRIPTIVE DATA: The database was launched in 2011. Every year since then ~5,500 inpatients and 7,500 outpatients...... have been registered annually in the database. A total of 24,083 inpatients and 29,918 outpatients have been registered. The DDD produces an annual report published on the Internet. CONCLUSION: The DDD can become an important tool for quality improvement and research, when the reporting is more...

  7. Pärt: Fratres in sechs Versionen. Festina lente. Summa / C. S.

    Index Scriptorium Estoniae

    C. S.

    1997-01-01

    Uuest heliplaadist "Pärt: Fratres in sechs Versionen. Festina lente. Summa. Cantus in memoriam Benjamin Britten. Orchester der Ungarischen Staatsoper, Tamas Benedek". Naxos CD 8 553 750 (WD:79'06") DDD

  8. Prokofiev: The Fiery Angel.Gösta Ohlin Vocal Ensemble / David J. Fanning

    Index Scriptorium Estoniae

    Fanning, David J.

    1991-01-01

    Uuest heliplaadist "Prokofiev: The Fiery Angel.Gösta Ohlin Vocal Ensemble, Gothenburg Pro Musica Chamber Choir and Symphony Orchestra, Neeme Järvi" DG CD 431 669-2 GH2 (two discs, nas:118 minutes:DDD)

  9. Stravinsky: The Rite of Spring. Canticum sacrum

    Index Scriptorium Estoniae

    1996-01-01

    Uuest heliplaadist "Stravinsky: The Rite of Spring. Canticum sacrum. Requiem canticles. Choral Variations on "Vom Himmel hoch". Lausanne Pro Arte Choir, Suisse Romande Chamber Choir and Orchestra, Neeme Järvi" Chandos CHAN 9408 (75 minutes:DDD)

  10. Organochlorine pesticide concentrations in fish, wood ducks, and fish eating birds from Mathews Brake and Morgan Brake National Wildlife Refuges, Holmes and Leflore Counties, Mississippi

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The U.S. Fish and Wildlife Service conducted this study because of the potential that DDTM (DDT and its metabolites, DDD and DDE) and other organochlorine pesticides...

  11. Chopin: Concerto for piano and orchestra No. 2 in F minor / Christopher Headington

    Index Scriptorium Estoniae

    Headington, Christopher

    1992-01-01

    Uuest heliplaadist "Chopin: Concerto for piano and orchestra No. 2 in F minor, Op. 21; Schumann: Concerto for piano and orchestra in A minor Op. 54. Philharmonia Orchestra, Neeme Järvi". Chandos CHAN9061 (62 minutes:DDD)

  12. Bartok: Concerto for Orchestra Sz 116 / Edward Seckerson

    Index Scriptorium Estoniae

    Seckerson, Edward

    1992-01-01

    Uuest heliplaadist "Bartok: Concerto for Orchestra Sz 116; Enescu: Romanian Rhapsodies Op. 11-No. 1 in A major No. 2 in D major. Royal Scottish Orchestra / Neeme Järvi" Chandos CHAN8947 (66 minutes:DDD)

  13. Raid, Kaljo: Symphony No. 2, "Stockholm" / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1996-01-01

    Uuest heliplaadist "Raid, Kaljo: Symphony No. 2, "Stockholm"; Tubin, Eduard: Elegy for Strings (arr. Raid). Symphony No. 11 (orch. Raid). Estonian State Symphony Orchestra, Arvo Volmer". Koch International Classics 37291-2 (48 minutes:DDD)

  14. Sekava Sibelius-kokonaisuus / Kimmo Korhonen

    Index Scriptorium Estoniae

    Korhonen, Kimmo

    1996-01-01

    Uuest heliplaadist "Sibelius: Karelia-sarja. Luonnotar. Andante festivo. Aallottaret. Kuningas Kristian II-sarja. Finlandia. Göteborgin sinfoniaorkesteri, Neeme Järvi". 1 CD Deutsche Grammophon 447 760-2GH (72 minutes: DDD)

  15. Bartok: Der holzgeschnitzte Prinz / Bernhard Uske

    Index Scriptorium Estoniae

    Uske, Bernhard

    1991-01-01

    Uuest heliplaadist "Bartok: Der holzgeschnitzte Prinz [The Wooden Prince complete ballet] op. 13. Ungarische Bilder [Hungarian Pictures]. Philharmonia Orchestra [The Philharmonia] Neeme Järvi". Chandos/Koch Records CD 8895 (WD:65'51") DDD

  16. Schmidt. Sinfonie Nr. 1 E-Dur; Strauss. Vier sinfonische Zwischenspiele aus Intermezzo. Detroit Symphony Orchestra, Neeme Järvi / Helge Grünewald

    Index Scriptorium Estoniae

    Grünewald, Helge

    1996-01-01

    Uuest heliplaadist "Schmidt. Sinfonie Nr. 1 E-Dur; Strauss. Vier sinfonische Zwischenspiele aus Intermezzo. Detroit Symphony Orchestra, Neeme Järvi. Chandos/Koch CD 9357 (WD: 68'20") DDD (WD:114'36")

  17. Ajattomuuden keidas / Harri Wessman

    Index Scriptorium Estoniae

    Wessman, Harri

    1997-01-01

    Uuest heliplaadist "Pärt, Arvo: Collage sur BACH. Fratres. Cantus in Memorium Benjamin Britten. Summa. Festina Lente. Tabula rasa. Tapiola Sinfonietta / Jean-Jacques Kantorow. Paavo Järvi". BIS-CD-834. 62:30 DDD

  18. Sekava Sibelius-kokonaisuus / Kimmo Korhonen

    Index Scriptorium Estoniae

    Korhonen, Kimmo

    1996-01-01

    Uuest heliplaadist "Sibelius: Karelia-sarja. Luonnotar. Andante festivo. Aallottaret. Kuningas Kristian II-sarja. Finlandia. Göteborgin sinfoniaorkesteri, Neeme Järvi". 1 CD Deutsche Grammophon 447 760-2GH (72 minutes: DDD)

  19. Sibelius, J. Kullervo op.7, Nationaler estnischer Männerchor, Stockholms Filharmoniska Orkester, Paavo Järvi / Andreas K. W. Meyer

    Index Scriptorium Estoniae

    Meyer, Andreas K. W.

    1998-01-01

    Uuest heliplaadist "Sibelius, J. Kullervo op.7. Randi Stene (Mezzosopran), Peter Mattei (Bariton), Nationaler estnischer Männerchor, Stockholms Filharmoniska Orkester, Paavo Järvi". Virgin/EMI 5 45292 2 (78'34") DDD Aufnahme: 1997.

  20. Sibelius: Der Sturm, Op. 109, Neeme Järvi / Gerhard Pätzig

    Index Scriptorium Estoniae

    Pätzig, Gerhard

    1990-01-01

    Uuest heliplaadist "Sibelius: Der Sturm, Op. 109, (Vorspiel und Konzertsuiten zu Shakespeares Drama), Cassazione, Op.6, Preludio, Tiera. Sinfonieorchester Göteborg, Neeme Järvi". BIS/ Disco-Center CD 448 71'43") DDD

  1. Pärt: Fratres in sechs Versionen. Festina lente. Summa / C. S.

    Index Scriptorium Estoniae

    C. S.

    1997-01-01

    Uuest heliplaadist "Pärt: Fratres in sechs Versionen. Festina lente. Summa. Cantus in memoriam Benjamin Britten. Orchester der Ungarischen Staatsoper, Tamas Benedek". Naxos CD 8 553 750 (WD:79'06") DDD

  2. Kalinnikov: Sinfonie Nr.2 A-Dur, Ouvertüre Zar Boris / Hanspeter Krellmann

    Index Scriptorium Estoniae

    Krellmann, Hanspeter

    1990-01-01

    Uuest heliplaadist "Kalinnikov: Sinfonie Nr.2 A-Dur, Ouvertüre Zar Boris, Die Zeder und die Palme. Scottish National Orchestra, Neeme Järvi" (AD: 1989) Chandos / Koch Records CD 8805 (WD: 59'40") DDD

  3. Stravinsky: The Rite of Spring. Canticum sacrum

    Index Scriptorium Estoniae

    1996-01-01

    Uuest heliplaadist "Stravinsky: The Rite of Spring. Canticum sacrum. Requiem canticles. Choral Variations on "Vom Himmel hoch". Lausanne Pro Arte Choir, Suisse Romande Chamber Choir and Orchestra, Neeme Järvi" Chandos CHAN 9408 (75 minutes:DDD)

  4. Stravinsky: The Rite of Spring / Hartmut, Lück

    Index Scriptorium Estoniae

    Lück, Hartmut

    1996-01-01

    Uuest heliplaadist "Stravinsky: The Rite of Spring. Canticum Sacrum. Requiem Canticles. Choral Variations on "Vom Himmel hoch". Lausanne Pro Arte Choir, Suisse Romande Chamber Choir and Orchestra, Neeme Järvi. Chandos CHAN 9408 (75 minutes:DDD)

  5. Stravinsky: The Rite of Spring / Hartmut, Lück

    Index Scriptorium Estoniae

    Lück, Hartmut

    1996-01-01

    Uuest heliplaadist "Stravinsky: The Rite of Spring. Canticum Sacrum. Requiem Canticles. Choral Variations on "Vom Himmel hoch". Lausanne Pro Arte Choir, Suisse Romande Chamber Choir and Orchestra, Neeme Järvi. Chandos CHAN 9408 (75 minutes:DDD)

  6. Kalinnikov: Sinfonie Nr.2 A-Dur, Ouvertüre Zar Boris / Hanspeter Krellmann

    Index Scriptorium Estoniae

    Krellmann, Hanspeter

    1990-01-01

    Uuest heliplaadist "Kalinnikov: Sinfonie Nr.2 A-Dur, Ouvertüre Zar Boris, Die Zeder und die Palme. Scottish National Orchestra, Neeme Järvi" (AD: 1989) Chandos / Koch Records CD 8805 (WD: 59'40") DDD

  7. Sibelius: Pohjola's Daughter; Night Ride and Sunrise; Four Legends from Kalevala (Lemminkäinen Suite). Gothenburg Symphony Orchestra, Neeme Järvi / Brian Hunt

    Index Scriptorium Estoniae

    Hunt, Brian

    1997-01-01

    Uuest heliplaadist "Sibelius: Pohjola's Daughter; Night Ride and Sunrise; Four Legends from Kalevala (Lemminkäinen Suite). Gothenburg Symphony Orchestra / Neeme Järvi. Deutsche Grammophon 453 426-2; 70:37 DDD

  8. Prokofiev: War and Peace - Symphonic Suite (arr. Palmer) / Ivan March

    Index Scriptorium Estoniae

    March, Ivan

    1993-01-01

    Uuest heliplaadist "Prokofiev: War and Peace - Symphonic Suite (arr. Palmer), Summer Night, Op. 123. Russian Overture, Op. 72. Philharmonia Orchestra / Neeme Järvi. Chandos ABTD 1598 CHAN9096 (64 minutes:DDD) Igor - Polovtsian Dances

  9. Sibelius, J. Kullervo op.7, Nationaler estnischer Männerchor, Stockholms Filharmoniska Orkester, Paavo Järvi / Andreas K. W. Meyer

    Index Scriptorium Estoniae

    Meyer, Andreas K. W.

    1998-01-01

    Uuest heliplaadist "Sibelius, J. Kullervo op.7. Randi Stene (Mezzosopran), Peter Mattei (Bariton), Nationaler estnischer Männerchor, Stockholms Filharmoniska Orkester, Paavo Järvi". Virgin/EMI 5 45292 2 (78'34") DDD Aufnahme: 1997.

  10. Prokofiev: The Fiery Angel.Gösta Ohlin Vocal Ensemble / David J. Fanning

    Index Scriptorium Estoniae

    Fanning, David J.

    1991-01-01

    Uuest heliplaadist "Prokofiev: The Fiery Angel.Gösta Ohlin Vocal Ensemble, Gothenburg Pro Musica Chamber Choir and Symphony Orchestra, Neeme Järvi" DG CD 431 669-2 GH2 (two discs, nas:118 minutes:DDD)

  11. Pärt: Berliner Messe / Rob Cowan

    Index Scriptorium Estoniae

    Cowan, Rob

    1998-01-01

    Uuest heliplaadist "Pärt: Berliner Messe. The Beatitudes. Annum per Annum. Magnificat. Seven Magnificat Antiphons. De profundis. Polyphony / Steven Layton with Andrew Lucas" Hyperion CDA66960 (74 minutes:DDD)

  12. Tüür, Erkki-Sven: Architectonics VI. Passion. Illusion / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1996-01-01

    Uuest heliplaadist "Tüür, Erkki-Sven: Architectonics VI. Passion. Illusion. Crystallisatio. Requiem. Estonian Philharmonic Chamber Choir, Tallinn Chamber Orchestra, Tõnu Kaljuste. ECM New Series 449 459-2 (64 minutes: DDD)

  13. Ajattomuuden keidas / Harri Wessman

    Index Scriptorium Estoniae

    Wessman, Harri

    1997-01-01

    Uuest heliplaadist "Pärt, Arvo: Collage sur BACH. Fratres. Cantus in Memorium Benjamin Britten. Summa. Festina Lente. Tabula rasa. Tapiola Sinfonietta / Jean-Jacques Kantorow. Paavo Järvi". BIS-CD-834. 62:30 DDD

  14. Driving forces behind the increasing cardiovascular treatment intensity.A dynamic epidemiologic model of trends in Danish cardiovascular drug utilization.

    DEFF Research Database (Denmark)

    Kildemoes, Helle Wallach; Andersen, Morten

    to 619 DDD/TID from 1996 to 2005 (117%). Population ageing accounted for 22 percentage points. Treatment intensity with statins increased from 5 to 121 DDD/TID. Population ageing accounted for one eighth of this increase. Increasing incidence rates was the main driving force behind the growing statin......Background: In many Western countries cardiovascular treatment intensity (DDD/1000 inhabitants/day, DDD/TID) has grown substantially during the last decades. Changed drug utilization pattern - rather than population ageing - was hypothesized to be the main driving force behind the growth....... Objectives: To investigate the driving forces behind the increasing treatment prevalence of cardiovascular drugs, in particular statins, by means of a dynamic epidemiologic drug utilization model. Methods: Material: All Danish residents older than 20 years by January 1, 1996 (4.0 million inhabitants), were...

  15. Variabilidad en la utilización de antihipertensivos entre las zonas básicas de salud de la Comunidad Valenciana Variations in antihypertensive drug utilization among primary care areas in the autonomous region of Valencia (Spain

    Directory of Open Access Journals (Sweden)

    Gabriel Sanfélix-Gimeno

    2010-10-01

    Full Text Available Objetivos: Estimar el consumo de cinco subgrupos terapéuticos empleados en el tratamiento de la hipertensión arterial en las zonas básicas de salud (ZBS de la Comunidad Valenciana, y analizar sus variaciones. Métodos: Estudio ecológico, descriptivo, del consumo de antihipertensivos en las ZBS de la Comunidad Valenciana en el año 2005, seguido de análisis de la variabilidad observada. Se estudiaron las 239 ZBS existentes mediante un análisis descriptivo de consumo (dosis diarias definidas [DDD] por 1.000 habitantes y día en pensionistas [DDD/1.000p/día] o activos [DDD/1.000a/día] y razones estandarizadas de utilización. Para el análisis de la variabilidad se utilizaron los estadísticos del análisis de áreas pequeñas. También se analizaron las asociaciones entre el consumo de los diferentes subgrupos terapéuticos. Resultados: El consumo global de antihipertensivos en la Comunidad Valenciana en 2005 fue de 235,6 DDD/1.000/día. Este consumo se concentra en los pensionistas (800DDD/1.000p/día frente a 73 DDD/1000a/día. El consumo de fármacos antihipertensivos, por subgrupos terapéuticos, osciló entre 442DDD/1000p/día para los IECA/ARA-II y 32DDD/1.000p/día para la doxazosina. Para los activos se observó un comportamiento similar. La variabilidad en el consumo fue moderada, con coeficientes de variación entre 0,20 y 0,40 (algo mayor en los activos. Los consumos de los diferentes grupos terapéuticos correlacionaron fuertemente entre sí. Conclusiones: Este estudio muestra una notable variabilidad en el consumo global de antihipertensivos por ZBS en la Comunidad Valenciana, probablemente debida a un problema de infrautilización en las ZBS con bajo consumo.Objectives: To estimate consumption of five subgroups of antihypertensive drugs by primary care areas and to analyze its variation. Methods: We performed an ecological, descriptive study of antihypertensive consumption in 239 primary care areas in the autonomous region of

  16. Various / Barry Witherden

    Index Scriptorium Estoniae

    Witherden, Barry

    1996-01-01

    Uuest heliplaadist "Various. John Keys (organ), Andrew Angus (bass). Vasari Singers / Jeremy Backhouse". EMI Eminence 7243 5 65 903 2. 74:09 DDD. Plaadil ka A. Pärdi "Summa", "The Beautitudes", "Seven Magnificat Antiphons"

  17. Pärt: Berliner Messe / Rob Cowan

    Index Scriptorium Estoniae

    Cowan, Rob

    1998-01-01

    Uuest heliplaadist "Pärt: Berliner Messe. The Beatitudes. Annum per Annum. Magnificat. Seven Magnificat Antiphons. De profundis. Polyphony / Steven Layton with Andrew Lucas" Hyperion CDA66960 (74 minutes:DDD)

  18. The defined daily dose as a measure of drug consumption in South ...

    African Journals Online (AJOL)

    drugs. The traditional measures, viz. cost and volume studies, have inherent shortcomings when drug consumption ... drug utilisation in South Africa The DDD methodology has ..... Drug Utilization in Norway during the 1970s -Increases.

  19. Bartok: Der holzgeschnitzte Prinz / Bernhard Uske

    Index Scriptorium Estoniae

    Uske, Bernhard

    1991-01-01

    Uuest heliplaadist "Bartok: Der holzgeschnitzte Prinz [The Wooden Prince complete ballet] op. 13. Ungarische Bilder [Hungarian Pictures]. Philharmonia Orchestra [The Philharmonia] Neeme Järvi". Chandos/Koch Records CD 8895 (WD:65'51") DDD

  20. Jolivet: Complete Flute Music, Vol. 2 / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1996-01-01

    Uuest heliplaadist "Jolivet: Complete Flute Music, Vol. 2. Kroumata Percussion Ensemble, Tapiola Sinfonietta, Paavo Järvi". BIS CD 739 (64 minutes: DDD). Item marked from CD630 (6/94), CD272, remainder new to UK

  1. Tüür, Erkki-Sven: Architectonics VI. Passion. Illusion / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1996-01-01

    Uuest heliplaadist "Tüür, Erkki-Sven: Architectonics VI. Passion. Illusion. Crystallisatio. Requiem. Estonian Philharmonic Chamber Choir, Tallinn Chamber Orchestra, Tõnu Kaljuste. ECM New Series 449 459-2 (64 minutes: DDD)

  2. Sibelius: Der Sturm, Op. 109, Neeme Järvi / Gerhard Pätzig

    Index Scriptorium Estoniae

    Pätzig, Gerhard

    1990-01-01

    Uuest heliplaadist "Sibelius: Der Sturm, Op. 109, (Vorspiel und Konzertsuiten zu Shakespeares Drama), Cassazione, Op.6, Preludio, Tiera. Sinfonieorchester Göteborg, Neeme Järvi". BIS/ Disco-Center CD 448 71'43") DDD

  3. Bernstein: Prelude, Fugue and Riffs / Michel Parouty

    Index Scriptorium Estoniae

    Parouty, Michel

    1998-01-01

    Uuest heliplaadist "Bernstein: Prelude, Fugue and Riffs. Facsimile. West Side Story - Symphonic Dances. Divertimento. City of Birmingham Symphony Orchestra / Paavo Järvi" Virgin Classics VC5 45295-2 (68 minutes:DDD)

  4. Prokofiev: War and Peace - Symphonic Suite (arr. Palmer) / Ivan March

    Index Scriptorium Estoniae

    March, Ivan

    1993-01-01

    Uuest heliplaadist "Prokofiev: War and Peace - Symphonic Suite (arr. Palmer), Summer Night, Op. 123. Russian Overture, Op. 72. Philharmonia Orchestra / Neeme Järvi. Chandos ABTD 1598 CHAN9096 (64 minutes:DDD) Igor - Polovtsian Dances

  5. Bernstein: Prelude, Fugue and Riffs / Edward Greenfield

    Index Scriptorium Estoniae

    Greenfield, Edward

    1998-01-01

    Uuest heliplaadist "Bernstein: Prelude, Fugue and Riffs. Facsimile. West Side Story - Symphonic Dances. Divertimento. City of Birmingham Symphony Orchestra / Paavo Järvi. Virgin Classics VC5 45295-2 (68 minutes:DDD)

  6. Various / Barry Witherden

    Index Scriptorium Estoniae

    Witherden, Barry

    1996-01-01

    Uuest heliplaadist "Various. John Keys (organ), Andrew Angus (bass). Vasari Singers / Jeremy Backhouse". EMI Eminence 7243 5 65 903 2. 74:09 DDD. Plaadil ka A. Pärdi "Summa", "The Beautitudes", "Seven Magnificat Antiphons"

  7. An international multicenter study of antimicrobial consumption and resistance in Staphylococcus aureus isolates from 15 hospitals in 14 countries

    DEFF Research Database (Denmark)

    Westh, Henrik Torkil; Zinn, Christina Scheel; Rosdahl, Vibeke Thamdrup

    2004-01-01

    ), and similar antibiotics were grouped if they belonged to the same therapeutic subgroup. Variations in hospital size were corrected by using DDD per 1000 bed-days. The total antibiotic consumption in the 15 hospitals varied between 296 DDD/1000 bed-days and 1108 DDD/1000 bed-days. Differences in the usage......Antibiotic consumption during 1996 was measured in 15 large hospitals from 14 countries and 3000 consecutive Staphylococcus aureus samples were collected, allowing calculation of local resistance rates and typing of isolates. Antibiotic consumption data were converted to defined daily doses (DDD...... of therapeutical subgroups of antimicrobials varied significantly between hospitals. A positive correlation was found between S. aureus resistance to methicillin (MRSA) and consumption of beta-lactam combinations, between resistance to quinolones and consumption of beta-lactam combinations and carbapenems...

  8. Prokofiev: Cantata for the 20th Anniversary of the October Revolution / David J. Fanning

    Index Scriptorium Estoniae

    Fanning, David J.

    1993-01-01

    Uuest heliplaadist "Prokofiev: Cantata for the 20th Anniversary of the October Revolution, Op. 74 a. The Tale of the Stone Flower - experts. Philharmonia Chorus and Orchestra / Neeme Järvi" Chandos ABTD 1597; CHAN9095 (75 minutes:DDD)

  9. Pärt, Arvo: Seven Magnificat Antiphons / Barry Witherden

    Index Scriptorium Estoniae

    Witherden, Barry

    1996-01-01

    Uuest heliplaadist "Pärt, Arvo: Seven Magnificat Antiphons. Magnificat. Summa; Tormis, Veljo: The Curse Upon Iron. Karelian Destiny. BBC Singers, Bo Holton". Collins Classics 1472-2 (61 minutes: DDD)

  10. Prokofiev: Cantata for the 20th Anniversary of the October Revolution / David J. Fanning

    Index Scriptorium Estoniae

    Fanning, David J.

    1993-01-01

    Uuest heliplaadist "Prokofiev: Cantata for the 20th Anniversary of the October Revolution, Op. 74 a. The Tale of the Stone Flower - experts. Philharmonia Chorus and Orchestra / Neeme Järvi" Chandos ABTD 1597; CHAN9095 (75 minutes:DDD)

  11. Black crowned night herons as indicators of estuarine health

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The results of the organochlorine scan are shown in table 1. Eggs from the Newark Bay colony had significantly higher levels of p, p' - DDD, heptachlor epoxide,...

  12. Elucidating turnover pathways of bioactive small molecules by isotopomer analysis: the persistent organic pollutant DDT.

    Directory of Open Access Journals (Sweden)

    Ina Ehlers

    Full Text Available The persistent organic pollutant DDT (1,1,1-trichloro-2,2-bis(4-chlorophenylethane is still indispensable in the fight against malaria, although DDT and related compounds pose toxicological hazards. Technical DDT contains the dichloro congener DDD (1-chloro-4-[2,2-dichloro-1-(4-chlorophenylethyl]benzene as by-product, but DDD is also formed by reductive degradation of DDT in the environment. To differentiate between DDD formation pathways, we applied deuterium NMR spectroscopy to measure intramolecular deuterium distributions (2H isotopomer abundances of DDT and DDD. DDD formed in the technical DDT synthesis was strongly deuterium-enriched at one intramolecular position, which we traced back to 2H/1H fractionation of a chlorination step in the technical synthesis. In contrast, DDD formed by reductive degradation was strongly depleted at the same position, which was due to the incorporation of 2H-depleted hydride equivalents during reductive degradation. Thus, intramolecular isotope distributions give mechanistic information on reaction pathways, and explain a puzzling difference in the whole-molecule 2H/1H ratio between DDT and DDD. In general, our results highlight that intramolecular isotope distributions are essential to interpret whole-molecule isotope ratios. Intramolecular isotope information allows distinguishing pathways of DDD formation, which is important to identify polluters or to assess DDT turnover in the environment. Because intramolecular isotope data directly reflect isotope fractionation of individual chemical reactions, they are broadly applicable to elucidate transformation pathways of small bioactive molecules in chemistry, physiology and environmental science.

  13. In vitro adrenal bioactivation and effects on steroid metabolism of DDT, PCBs and their metabolites in the gray seal (Halichoerus grypus)

    Energy Technology Data Exchange (ETDEWEB)

    Lund, B.O. (Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Pharmacology and Toxicology)

    1994-06-01

    The irreversible binding of the DDT metabolites o,p[prime]-DDD [2-(2-chlorophenyl)-2(4-chlorophenyl)-1,1-dichloroethane] and MeSO[sub 2]-DDE [3-methylsulfonyl-2,2-bis(4-chlorophenyl)-1,1-dichloroethene], as well as their potential to inhibit mitochondrial steroid 11[beta]-hydroxylation in the gray seal adrenal gland, was studied. The adrenal bioactivated both o,p[prime]-DDD and MeSO[sub 2[minus

  14. Elucidating turnover pathways of bioactive small molecules by isotopomer analysis: the persistent organic pollutant DDT.

    Science.gov (United States)

    Ehlers, Ina; Betson, Tatiana R; Vetter, Walter; Schleucher, Jürgen

    2014-01-01

    The persistent organic pollutant DDT (1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane) is still indispensable in the fight against malaria, although DDT and related compounds pose toxicological hazards. Technical DDT contains the dichloro congener DDD (1-chloro-4-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene) as by-product, but DDD is also formed by reductive degradation of DDT in the environment. To differentiate between DDD formation pathways, we applied deuterium NMR spectroscopy to measure intramolecular deuterium distributions (2H isotopomer abundances) of DDT and DDD. DDD formed in the technical DDT synthesis was strongly deuterium-enriched at one intramolecular position, which we traced back to 2H/1H fractionation of a chlorination step in the technical synthesis. In contrast, DDD formed by reductive degradation was strongly depleted at the same position, which was due to the incorporation of 2H-depleted hydride equivalents during reductive degradation. Thus, intramolecular isotope distributions give mechanistic information on reaction pathways, and explain a puzzling difference in the whole-molecule 2H/1H ratio between DDT and DDD. In general, our results highlight that intramolecular isotope distributions are essential to interpret whole-molecule isotope ratios. Intramolecular isotope information allows distinguishing pathways of DDD formation, which is important to identify polluters or to assess DDT turnover in the environment. Because intramolecular isotope data directly reflect isotope fractionation of individual chemical reactions, they are broadly applicable to elucidate transformation pathways of small bioactive molecules in chemistry, physiology and environmental science.

  15. Comparison of outpatient utilization of psychopharmaceuticals between Croatia and Scandinavian countries (2001-2003

    Directory of Open Access Journals (Sweden)

    Z. Šostar

    2007-02-01

    Full Text Available Neurotropic drugs account for 15% of total drug utilization in Croatia. The aim was to estimate outpatient consumption of psychotropic drugs in Croatia in correlation with Scandinavian countries. Data on drug utilization in Croatia were collected and analyzed for the 2001-2003 period. Data were obtained from Zagreb Municipal Pharmacy and extrapolated to the total number of pharmacies. All drugs were classified according to Anatomical-Therapeutic-Chemical (ATC drug classification system. These data were used to calculate a number of defined daily doses (DDD and DDD per 1000 inhabitants per day (DDD/TID. Data of the Nordic Medico-Statistical Committee were used for Scandinavian countries. In Croatia, total utilization of psychopharmaceuticals of 144.9 DDD/TID in 2001, 148.9 DDD/TID in 2002 and 141.9 DDD/TID in 2003 exceeded that recorded in Scandinavian countries. Anxiolytics accounted for 90% of psycholeptic utilization in Croatia versus 22% in Sweden and 34% in Finland. The anxiolytic/antidepressant ratio decreased in Croatia by 35.19% (7.19 in 2001 and 4.66 in 2003, whereas in Scandinavian countries it showed a constant rate (0.7 in Finland, 0.4 in Denmark and Norway, and 0.3 in Sweden.

  16. A Precise Drunk Driving Detection Using Weighted Kernel Based on Electrocardiogram.

    Science.gov (United States)

    Wu, Chung Kit; Tsang, Kim Fung; Chi, Hao Ran; Hung, Faan Hei

    2016-05-09

    Globally, 1.2 million people die and 50 million people are injured annually due to traffic accidents. These traffic accidents cost $500 billion dollars. Drunk drivers are found in 40% of the traffic crashes. Existing drunk driving detection (DDD) systems do not provide accurate detection and pre-warning concurrently. Electrocardiogram (ECG) is a proven biosignal that accurately and simultaneously reflects human's biological status. In this letter, a classifier for DDD based on ECG is investigated in an attempt to reduce traffic accidents caused by drunk drivers. At this point, it appears that there is no known research or literature found on ECG classifier for DDD. To identify drunk syndromes, the ECG signals from drunk drivers are studied and analyzed. As such, a precise ECG-based DDD (ECG-DDD) using a weighted kernel is developed. From the measurements, 10 key features of ECG signals were identified. To incorporate the important features, the feature vectors are weighted in the customization of kernel functions. Four commonly adopted kernel functions are studied. Results reveal that weighted feature vectors improve the accuracy by 11% compared to the computation using the prime kernel. Evaluation shows that ECG-DDD improved the accuracy by 8% to 18% compared to prevailing methods.

  17. A Precise Drunk Driving Detection Using Weighted Kernel Based on Electrocardiogram

    Directory of Open Access Journals (Sweden)

    Chung Kit Wu

    2016-05-01

    Full Text Available Globally, 1.2 million people die and 50 million people are injured annually due to traffic accidents. These traffic accidents cost $500 billion dollars. Drunk drivers are found in 40% of the traffic crashes. Existing drunk driving detection (DDD systems do not provide accurate detection and pre-warning concurrently. Electrocardiogram (ECG is a proven biosignal that accurately and simultaneously reflects human’s biological status. In this letter, a classifier for DDD based on ECG is investigated in an attempt to reduce traffic accidents caused by drunk drivers. At this point, it appears that there is no known research or literature found on ECG classifier for DDD. To identify drunk syndromes, the ECG signals from drunk drivers are studied and analyzed. As such, a precise ECG-based DDD (ECG-DDD using a weighted kernel is developed. From the measurements, 10 key features of ECG signals were identified. To incorporate the important features, the feature vectors are weighted in the customization of kernel functions. Four commonly adopted kernel functions are studied. Results reveal that weighted feature vectors improve the accuracy by 11% compared to the computation using the prime kernel. Evaluation shows that ECG-DDD improved the accuracy by 8% to 18% compared to prevailing methods.

  18. Indicadores de calidad de la prescripción en dosis diarias definidas: ¿Lo estamos haciendo bien? Quality prescription indicators in defined daily doses: Are we getting it right?

    Directory of Open Access Journals (Sweden)

    Francisco Caamaño-Isorna

    2008-10-01

    Full Text Available Los indicadores de la calidad de la prescripción de grado potencial de uso (IGPU se definen como la proporción que representa el consumo de determinados principios activos frente al consumo total de su categoría anatómica terapéutica. En los últimos años, los IGPU que se han ido definiendo en nuestro país utilizan la dosis diaria definida (DDD como unidad de medida. Y aunque la DDD no es necesariamente igual a la dosis terapéutica equivalente (DTE, se ha argumentado que es una unidad de medida estándar y, por tanto, válida. Esto podría no ser correcto, ya que las relaciones entre DTE y DDD son distintas en los diferentes fármacos, incluso dentro de la misma categoría anatómica terapéutica. Por ello, la utilización de las DDD en los IGPU puede llevar a incentivar o desincentivar la prescripción de un fármaco en función de su relación DTE/DDD.Quality prescription indicators of use potential level (UPLI are defined as the proportion that represents consumption of specific active principles as opposed to the total consumption of the anatomical therapeutic category. The UPLIs that have gradually been defined in Spain employ the defined daily dose (DDD as the unit of measurement. Although the DDD is not necessarily the same as the therapeutic equivalent dose (TED, some authors have argued that the DDD is a standard unit of measurement and is therefore valid. However, this view may not be correct, given that the relationships between the TED and the DDD differ, depending on the drug, even within the same anatomical therapeutic category. Therefore, the use of DDDs in UPLI s may lead to prescription of a medicine being encouraged or discouraged depending on its TED/DDD ratio.

  19. Mitotane effects in a H295R xenograft model of adjuvant treatment of adrenocortical cancer.

    Science.gov (United States)

    Lindhe, O; Skogseid, B

    2010-09-01

    Adrenocortical cancer is one of the most aggressive endocrine malignancies. Growth through the capsule or accidental release of cancer cells during surgery frequently results in metastatic disease. We investigated the antitumoral effect of 2 adrenocorticolytic compounds, O, P'-DDD and MeSO2-DDE, in the adrenocortical cell line H295R both in vitro and as a xenograft model in vivo. H295R cells were injected s. c. in nude mice. O, P'-DDD, MeSO2-DDE, or oil (control) was administered i. p., either simultaneously with cell injection at day 0 (mimicking adjuvant treatment), or at day 48 (established tumors). Accumulation of PET tracers [ (11)C]methionine (MET), [ (11)C] metomidate (MTO), 2-deoxy-2-[ (18)F]fluoro-d-glucose (FDG), and [ (18)F]-l-tyrosine (FLT) in the aggregates were assessed +/- drug treatment in vitro. Tumor growth was significantly inhibited when O, P'-DDD was given at the same time as injection of tumor cells. No significant growth inhibition was observed after treatment with O, P'-DDD at day 48. A significant reduction in FLT uptake and an increased FDG uptake, compared to control, were observed following treatment with 15 microM O, P'-DDD (p<0.01) in vitro. MeSO2-DDE (15 microM) treatment gave rise to a reduced MET and an increased FLT uptake (p<0.01). Both compounds reduced the uptake of MTO compared to control (p<0.01). Treatment with O, P'-DDD simultaneously to inoculation of H295R cells in mice, imitating release of cells during surgery, gave a markedly better effect than treatment of established H295R tumors. We suggest that FLT may be a potential PET biomarker when assessing adrenocortical cancer treatment with O,P'-DDD. Further studies in humans are needed to investigate this.

  20. Evaluation of quinolone antibacterial consumption

    Directory of Open Access Journals (Sweden)

    E. P. Bernaz

    2016-08-01

    Full Text Available Quinolones are broad-spectrum antibiotics that play an important role in the treatment of serious bacterial infections, especially hospital-acquired infections and others in which resistance to older antibacterial classes is suspected and as first-line therapy is recommended. To determine the place, compare and analyze the use of quinolone antibacterial in the most important departments of EMI during 2009 to 2014 and to assess their results for improvement of patients treatment quality was designed this study. In the evaluated period consumption of quinolone antibacterial in EMI recorded a decline from 91 to 46 DDD/1000 or by 49.45%, in IC departaments from 338.6 to 132.07 or by 61%, and vice versa in SSOT departments an increase from 41.28 to 57.59 DDD/1000 or by 31.51%. Medium annual consumption in all institution recorded 63.03 DDD/1000, respectvely 174.90 in IC and 45.10 in SSOT departments. In 2014 IC departments recorded 2439.8 lei per DDD/1000, that was 8.72 times more than cost of 279.9 lei in SSOT departments and 7.51 times than 324.96 lei per DDD/1000 in all EMI. The yearly medium in EMI is around the same with all other international hospitals of 66.13 DDD/1000 and by 27.23% higher than 49.54 DDD/1000 recorded in large acute Australian public hospitals. The obtained results will be an important data for optimization in planning annual hospital necessities and rational antimicrobial prescribing as well as suggest the idea for expansion development and support antimicrobial stewardship initiatives.

  1. Comparison of Long-Term Effect of Dual-Chamber Pacing and Alcohol Septal Ablation in Patients with Hypertrophic Obstructive Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Jan Krejci

    2013-01-01

    Full Text Available Introduction. Nonpharmacological treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM comprises surgical myectomy (SME, alcohol septal ablation (ASA, and dual-chamber (DDD pacing. The aim of the study was to compare the long-term effect of DDD pacing and ASA in symptomatic HOCM patients. Patients and Methods. We evaluated retrospective data from three cardiocenters; there were 24 patients treated with DDD pacing included and 52 treated with ASA followed for 101 ± 49 and 87 ± 23 months, respectively. Results. In the group treated with DDD pacing, the left ventricle outflow tract gradient (LVOTG decreased from 82 ± 44 mmHg to 21 ± 21 mmHg, and NYHA class improved from 2.7 ± 0.5 to 2.1 ± 0.6 (both P<0.001. In the ASA-treated group, a decline in LVOTG from 73 ± 38 mmHg to 24 ± 26 mmHg and reduction in NYHA class from 2.8 ± 0.5 to 1.7 ± 0.8 were observed (both P<0.001. The LVOTG change was similar in both groups (P=0.264, and symptoms were more affected by ASA (P=0.001. Conclusion. ASA and DDD pacing were similarly effective in reducing LVOTG. The symptoms improvement was more expressed in patients treated with ASA.

  2. Effect of dual-chamber pacemaker on cardiac function in elderly chronic heart failure%双腔起搏不同房室传导间期对老年慢性心力衰竭患者心功能的影响

    Institute of Scientific and Technical Information of China (English)

    史扬; 耿仁义; 刘涛

    2008-01-01

    目的 观察双腔起搏时两种不同的房室传导问期对老年慢性心力衰谒患者心功能的影响.方法 26例植入双腔起搏器的老年慢性心力衰竭患者,采用自身对照分为长AV间期组(DDD-1)和短AV间期组(DDD-s),分别观察1周,行超声心动图检查,比较两组左室射血分数(LVEF)、左室舒张末直径(LVEDD)、左室收缩末直径(LVESD)的变化.结果 DDD-s组LVEF(50.92±6.99)较DDD-1组LVEF(53.46±4.87)明显降低,而LVEDD、LVESD则两组间无改变.结论 由于DDD-s的完全右室起搏,可引起老年慢性心力衰竭患者心功能恶化.

  3. Optimal Cardiac Resynchronization Therapy Pacing Rate in Non-Ischemic Heart Failure Patients

    DEFF Research Database (Denmark)

    Ghotbi, Adam Ali; Sander, Mikael; Køber, Lars

    2015-01-01

    by microneurography (MSNA), peak oxygen consumption (pVO2), N-terminal pro-brain natriuretic peptide (p-NT-proBNP), echocardiography and QoL. RESULTS: DDD-80 pacing for 3 months increased the mean heart rate from 77.3 to 86.1 (p = 0.001) and reduced sympathetic activity compared to DDD-60 (51±14 bursts/100 cardiac......BACKGROUND: The optimal pacing rate during cardiac resynchronization therapy (CRT) is unknown. Therefore, we investigated the impact of changing basal pacing frequencies on autonomic nerve function, cardiopulmonary exercise capacity and self-perceived quality of life (QoL). METHODS: Twelve CRT...... patients with non-ischemic heart failure (NYHA class II-III) were enrolled in a randomized, double-blind, crossover trial, in which the basal pacing rate was set at DDD-60 and DDD-80 for 3 months (DDD-R for 2 patients). At baseline, 3 months and 6 months, we assessed sympathetic nerve activity...

  4. Trends in permanent pacemaker implantation in the United States from 1993 to 2009: increasing complexity of patients and procedures.

    Science.gov (United States)

    Greenspon, Arnold J; Patel, Jasmine D; Lau, Edmund; Ochoa, Jorge A; Frisch, Daniel R; Ho, Reginald T; Pavri, Behzad B; Kurtz, Steven M

    2012-10-16

    This study sought to define contemporary trends in permanent pacemaker use by analyzing a large national database. The Medicare National Coverage Determination for permanent pacemaker, which emphasized single-chamber pacing, has not changed significantly since 1985. We sought to define contemporary trends in permanent pacemaker use by analyzing a large national database. We queried the Nationwide Inpatient Sample to identify permanent pacemaker implants between 1993 and 2009 using the International Classification of Diseases-Ninth Revision-Clinical Modification procedure codes for dual-chamber (DDD), single-ventricular (VVI), single-atrial (AAI), or biventricular (BiV) devices. Annual permanent pacemaker implantation rates and patient demographics were analyzed. Between 1993 and 2009, 2.9 million patients received permanent pacemakers in the United States. Overall use increased by 55.6%. By 2009, DDD use increased from 62% to 82% (p pacemaker use fell from 36% to 14% (p = 0.01). Use of DDD devices was higher in urban, nonteaching hospitals (79%) compared with urban teaching hospitals (76%) and rural hospitals (72%). Patients with private insurance (83%) more commonly received DDD devices than Medicaid (79%) or Medicare (75%) recipients (p pacemakers in the United States. Although DDD device use is increasing, whereas single-chamber ventricular pacemaker use is decreasing. Patients are becoming older and have more medical comorbidities. These trends have important health care policy implications. Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  5. Design and Fabrication of Drug Delivery Devices with Complex Architectures Based on Three-dimensional Printing Technique

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    A new type of implantable drug delivery devices (DDD) with complicated architectures were fabricated by three-dimensional printing technique, employing levofloxacin (LVFX) as a model drug. Processing parameters were optimized in view of the layer thickness, spacing between printed lines, flow rate of liquid binder and the fast axis speed. The prepared DDD prototype consists of a double- layer structure, of which the upper region is a reservoir system and the lower region is a matrix one. The in vitro release test revealed that LVFX was released in a dual-pulse pattern. This DDD may present a new strategy for the prophylaxis and treatment of diseases such ns bone infections in the near future.

  6. Persistent atrial fibrillation during pacemaker replacement%起搏器更换时持续性心房颤动的发生情况分析

    Institute of Scientific and Technical Information of China (English)

    高运来; 郁志明; 张常莹; 郑杰; 李库林; 吴小庆; 王如兴

    2013-01-01

    Objective To study prevalence of persistent atrial fibrillation(PAF) during pacemaker replacement.Methods One hundred and twenty-four patients scheduled to pacemaker replacement were divided into sick sinus syndrome (SSS) group and atrioventricular block (AVB) group receiving VVI (R) or DDD (R) pacing according to pacing mode.PAF during replacement was studied compared with last time implantation.Results The occurrence of PAF was 26.6% (33/124) over (8.2± 2.5)years'follow-up.As to SSS group,the occurrence of PAF was 34.4% (21/61) in patients with VVI (R) pacing and 18.2% (4/22) in patients with DDD (R) pacing during pacemaker replacement,respectively.Patients with VVI (R) pacing had higher prevalence of PAF than that in patients with DDD(R) pacing (34.4% vs 18.2%,P<0.05).As to AVB group,the occurrence of PAF was 23.3% (7/30)in patients with VVI (R) pacing and 9.1% (1/11)in patients with DDD (R) pacing during replacement,respectively.Patients with VVI (R) pacing had higher prevalence of PAF than that in patients with DDD(R) pacing(23.3% vs 9.1%,P<0.05).Conclusion PAF was common during pacemaker replacement.Patients with VVI(R) pacing had higher prevalence of PAF during replacement than that in patients with DDD(R) pacing no matter what was the original cause of diseases.%目的 探讨起搏器更换时持续性心房颤动(PAF)的发生情况.方法 124例行起搏器更换的患者根据病因分为病态窦房结综合征(SSS)组及房室阻滞(AVB)组,根据起搏模式分为DDD(R)及VVI(R)组,分析PAF的发生情况.结果 平均更换时间为(8.2±2.5)年,PAF发生率为26.6%(33/124).SSS组61例行VVI(R)起搏,22例行DDD(R)起搏.前者更换时PAF占34.4%(21/61),后者更换时PAF占18.2%(4/22).VVI(R)起搏PAF发生率高于DDD(R)起搏(34.4%对18.2%,P<0.05).AVB组30例行VVI(R)起搏,11例行DDD(R)起搏.前者更换时PAF占23.3% (7/30),后者更换时PAF占9.1%(1/11).VVI(R)起搏PAF发生率高于DDD(R)起搏(23.3

  7. Use of proton pump inhibitors after anti-reflux surgery

    DEFF Research Database (Denmark)

    Lodrup, A.; Pottegård, Anton; Hallas, J.

    2014-01-01

    by an average PPI use of >= 180 defined daily doses (DDDs) per year. Kaplan-Meier curves and Cox proportional hazards model were used for statistics. Results 3465 patients entered the analysis. 12.7% used no PPI in the year before surgery, while 14.2%, 13.4% and 59.7% used 1-89 DDD, 90-179 DDD and >= 180 DDD...... healthcare registries. Design A nationwide retrospective follow-up study of all patients aged >= 18 and undergoing first-time ARS in Denmark during 1996-2010. Two outcome measures were used: redemption of first PPI prescription after ARS (index prescription) and a marker of long-term use, defined...

  8. The use of antibiotics in hospitalized adult typhoid patients in an Indonesian hospital

    Directory of Open Access Journals (Sweden)

    Anggita Bunga Anggraini

    2014-08-01

    Full Text Available AbstrakLatar belakang:Demam tifoid menduduki peringkat ke tiga dari 10 besar penyakit terbanyak pada pasien rawat inap di rumah sakit (RS di Indonesia pada tahun 2010. Selain itu terdapat peningkatan resistensi dan kasus-kasus karier, dan relaps. Penelitian ini menyajikan hasil analisis data tentang penggunaan antibiotik pada pasien tifoid dewasa rawat inap di suatu RS di Indonesia. Metode: Data penelitian diekstrak dari rekam medik pasien tifoid dewasa yang dirawat inap di RS PMI Bogor periode Juli-Desember 2012. Analisis dilakukan dengan kualitatif (DU90% dan kuantitatif (DDD/shr dengan menggunakan metode ATC/DDD. Hasil: Dari 459 pasien tifoid dewasa rawat inap diperoleh DDD/shr pasien tifoid dewasa rawat inap yang menggunakan antibiotik selama dari Juli sampai Desember 2012 sebesar 6,35 DDD/shr. Seftriakson merupakan antibiotika yang dipakai tertinggi yang setara 4,10 DDD/shr, yang berarti bahwa di antara 100 pasien tifoid, 4 pasien memakai seftriakson 2 g setiap hari. Selanjutnya, obat pada segmen 10% lebih banyak dibandingkan pada segmen 90%. Di antara 26 jenis antibiotika, 7 jenis di antaranya termasuk pada segmen DU 90% yaitu seftriakson (64,54%; levofloksasin (13,90%; ciprofloksasin (3,57%; meropenem (2,80%; metronidazol (2,52%; ampisilin-sulbaktam (1,65%; dan sefditoren pivoksil (1,60%.Kesimpulan:Antibiotik seftriakson yang paling banyak digunakan pada perawatan tifoid pasien dewasa rawat inap di rumah sakit. (Health Science Indones 2014;1:40-3Kata kunci:antibiotik, tifoid, ATC/DDD, DU 90%AbstractBackground: Typhoid fever was the third ranked disease among the top 10 diseases in hospitalized patients in Indonesia in 2011. There were increased drug resistance, increased number of carrier, and number of relapse cases. This study aimed to analyze the use of antibiotics in hospitalized adult typhoid patients in a hospital in Indonesia. Methods: The data were extracted from medical records of drug use in adult typhoid patients hospitalized

  9. A novel multiple-stage antimalarial agent that inhibits protein synthesis

    Science.gov (United States)

    Baragaña, Beatriz; Hallyburton, Irene; Lee, Marcus C. S.; Norcross, Neil R.; Grimaldi, Raffaella; Otto, Thomas D.; Proto, William R.; Blagborough, Andrew M.; Meister, Stephan; Wirjanata, Grennady; Ruecker, Andrea; Upton, Leanna M.; Abraham, Tara S.; Almeida, Mariana J.; Pradhan, Anupam; Porzelle, Achim; Martínez, María Santos; Bolscher, Judith M.; Woodland, Andrew; Norval, Suzanne; Zuccotto, Fabio; Thomas, John; Simeons, Frederick; Stojanovski, Laste; Osuna-Cabello, Maria; Brock, Paddy M.; Churcher, Tom S.; Sala, Katarzyna A.; Zakutansky, Sara E.; Jiménez-Díaz, María Belén; Sanz, Laura Maria; Riley, Jennifer; Basak, Rajshekhar; Campbell, Michael; Avery, Vicky M.; Sauerwein, Robert W.; Dechering, Koen J.; Noviyanti, Rintis; Campo, Brice; Frearson, Julie A.; Angulo-Barturen, Iñigo; Ferrer-Bazaga, Santiago; Gamo, Francisco Javier; Wyatt, Paul G.; Leroy, Didier; Siegl, Peter; Delves, Michael J.; Kyle, Dennis E.; Wittlin, Sergio; Marfurt, Jutta; Price, Ric N.; Sinden, Robert E.; Winzeler, Elizabeth A.; Charman, Susan A.; Bebrevska, Lidiya; Gray, David W.; Campbell, Simon; Fairlamb, Alan H.; Willis, Paul A.; Rayner, Julian C.; Fidock, David A.; Read, Kevin D.; Gilbert, Ian H.

    2015-06-01

    There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to overcome emerging drug resistance. Here we describe the discovery of DDD107498, a compound with a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite, with good pharmacokinetic properties and an acceptable safety profile. DDD107498 demonstrates potential to address a variety of clinical needs, including single-dose treatment, transmission blocking and chemoprotection. DDD107498 was developed from a screening programme against blood-stage malaria parasites; its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis. This discovery of eEF2 as a viable antimalarial drug target opens up new possibilities for drug discovery.

  10. [Evaluation of antimicrobial consumption en 15 Chilean hospitals: Results of a collaborative work, 2013].

    Science.gov (United States)

    Domínguez, Isabel; Rosales, Ruth; Cabello, Ángela; Bavestrello, Luis; Labarca, Jaime

    2016-06-01

    Surveillance of antimicrobial consumption is a central part in programs of antibiotic stewardship. However, in Chile there are no national data on antibiotic consumption representing a significant number of hospitals by clinical services. In 2013 a survey was sent to multiple Chilean hospitals to evaluate antimicrobial consumption in medical services (MS), surgery services (SS) and critical care units (ICU). We used the standardized methodology recommended by the WHO, using the number of DDD/100 days beds. In the MS and SS beta-lactam and no beta-lactam antibiotics commonly used were evaluated. In the ICU consumption vancomycin, linezolid, imipenem, merope-nem, colistin and tigecycline was evaluated. Fifteen hospitals reported the density of antimicrobial consumption. Ceftriaxone and cloxacillin were the most commonly used antibiotics in general services (average cloxacillin 4,9 DDD/100 bed days in MS and 8,0 DDD/100 in SS; ceftriaxone 13,5 DDD/100 in MS and 16,7 DDD/100 in SS). In the SS there was also a significant consumption of metronidazole (average 14,5 DDD/100 bed days). In the ICU there was an important variability of consumption of selected antibiotics. This study reports the average and range of antibiotic consumption in MS, SS, and ICU from a significant number of hospitals in the country, during 2013. This information allows hospitals to compare their consumption of antibiotics with a significant sample of Chilean hospitals. Analysis of this information should consider a careful interpretation according to the sample shown here and the reality of each hospital.

  11. Impact of the introduction of mandatory generic substitution in South Africa: private sector sales of generic and originator medicines for chronic diseases.

    Science.gov (United States)

    Gray, Andrew Lofts; Santa-Ana-Tellez, Yared; J Wirtz, Veronika

    2016-12-01

    To assess the impact of mandatory offer of generic substitution, introduced in South Africa in May 2003, on private sector sales of generic and originator medicines for chronic diseases. Private sector sales data (June 2001 to May 2005) were obtained from IMS Health for proton pump inhibitors (PPIs; ATC code A02BC), HMG-CoA reductase inhibitors (statins; C10AA), dihydropyridine calcium antagonists (C08CA), angiotensin-converting enzyme inhibitors (ACE-I; C09AA) and selective serotonin reuptake inhibitors (SSRIs; N06AB). Monthly sales were expressed as defined daily doses per 1000 insured population per month (DDD/TIM). Interrupted time-series models were used to estimate the changes in slope and level of medicines use after the policy change. ARIMA models were used to correct for autocorrelation and stationarity. Only the SSRIs saw a significant rise in level of generic utilisation (0.2 DDD/TIM; P increase in slope (0.01 DDD/TIM, P = 0.016; 0.02 DDD/TIM, P < 0.001), while the originators showed a decrease in slope (-0.003 DDD/TIM, P = 0.046; -0.01 DDD/TIM, P < 0.001). There were insufficient data on generic statin use before the policy change to allow for analysis. The mandatory offer of generic substitution appeared to have had a quantifiable effect on utilisation patterns in the 2 years after May 2003. Managed care interventions that were already in place before the intervention may have blunted the extent of the changes seen in this period. Generic policies are an important enabling provision for cost-containment efforts. However, decisions taken outside of official policy may anticipate or differ from that policy, with important consequences. © 2016 John Wiley & Sons Ltd.

  12. Fluoroquinolone resistance during 2000–2005 : An observational study

    Directory of Open Access Journals (Sweden)

    Sheehan Paul

    2008-05-01

    Full Text Available Abstract Background Moxifloxacin is a respiratory fluoroquinolone with a community acquired pneumonia indication. Unlike other fluoroquinolones used in our healthcare system, moxifloxacin's urinary excretion is low and thus we hypothesized that increased use of moxifloxacin is associated with an increase in fluoroquinolone resistance amongst gram negative uropathogens. Methods All antibiograms for Gram negative bacteria were obtained for 2000 to 2005. The defined daily dose (DDD for each fluoroquinolone was computed according to World Health Organization criteria. To account for fluctuation in patient volume, DDD/1000 bed days was computed for each year of study. Association between DDD/1000 bed days for each fluoroquinolone and the susceptibility of Gram negative bacteria to ciprofloxacin was assessed using Pearson's Correlation Coefficient, r. Results During the study period, there were 48,261 antibiograms, 347,931 DDD of fluoroquinolones, and 1,943,338 bed days. Use of fluoroquinolones among inpatients decreased from 237.2 DDD/1000 bed days in 2000 to 115.2 DDD/1000 bed days in 2005. With the exception of Enterobacter aerogenes, moxifloxacin use was negatively correlated with sensitivity among all 13 Gram negative species evaluated (r = -0.07 to -0.97. When the sensitivities of all Gram negative organisms were aggregated, all fluoroquinolones except moxifloxacin were associated with increased sensitivity (r = 0.486 to 1.000 while moxifloxacin was associated with decreased sensitivity (r = -0.464. Conclusion Moxifloxacin, while indicated for empiric treatment of community acquired pneumonia, may have important negative influence on local antibiotic sensitivities amongst Gram negative organisms. This effect was not shared by other commonly used members of the fluoroquinolone class.

  13. Thoracal flat back is a risk factor for lumbar disc degeneration after scoliosis surgery.

    Science.gov (United States)

    Bernstein, Peter; Hentschel, Susanne; Platzek, Ivan; Hühne, Sebastian; Ettrich, Uwe; Hartmann, Albrecht; Seifert, Jens

    2014-06-01

    Lumbar segments below fused scoliotic spines are thought to be exposed to extraordinary stress. Although positive sagittal imbalance has come into focus, reports about factors influencing the outcome of these segments remain inconclusive. Our study aimed at identifying spinal risk factors for the development of lumbar degenerative disc disease (DDD) in surgically treated patients with adolescent idiopathic scoliosis (AIS). Retrospective comparative prognostic study (Level III) was conducted. Thirty-three patients were seen at an average follow-up of 7.5 years after either isolated selective anterior (n=18) or long combined anterior-posterior fusion (n=15) for AIS. Self-reported Scoliosis Research Society 22 questionnaire, physical examination including the detection of segmental pain and unspecific back pain, preoperative and postoperative whole-spine standing radiographs, and magnetic resonance imaging were obtained. Radiographic evaluation included the measurement of regional, coronal, and sagittal curve parameters and the assessment of spinal balance. Magnetic resonance imaging evaluation was done for preoperative and postoperative lumbar discs, according to the classification of Pfirrmann. Patients with low DDD (Pfirrmann grading flat-type lumbar lordosis in patients with severe DDD. Positive sagittal imbalance was associated with advanced DDD. Follow-up coronal parameters, trunk imbalance, instrumentation length, and lowest instrumented vertebra selection had no influence on DDD. Specific segmental pain could be attributed to a significantly higher coronal trunk imbalance (21 vs. 11 mm). This study establishes thoracal flat back as a risk factor for lumbar DDD after spinal fusion and supports the pathogenetic role of positive sagittal imbalance in this process. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Use of antibacterial agents in an intensive care unit in a hospital in Brazil

    Directory of Open Access Journals (Sweden)

    E.F. dos Santos

    2007-06-01

    Full Text Available It is essential to monitor the utilisation of antibacterial drugs in order to establish appropriate measures for their control. The pattern of usage of antibacterial drugs, and its association with indicators of hospital infection, has been investigated in a non-specialized adult intensive care unit (ICU located in Santa Luzia Hospital (Brasília, DF, Brazil. The study was conducted between January 2001 and June 2004. Data concerning the utilisation of systemic antibacterial drugs, classified according to the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD system, and indicators of hospital infection, defined according to the National Nosocomial Infections Surveillance (NNIS system, were obtained from appropriate hospital archives. During the study period, the average utilisation of antibacterial drugs was 1918.5 DDD units per 1000 patient-day (DDD1000. The three most used drugs were penicillins/beta-lactamase inhibitors (535.3 DDD1000, third generation cephalosporins (239.1 DDD1000 and quinolones (212.5 DDD1000. The total utilisation of antibacterial drugs was correlated significantly with the incidence of hospital infection (R = 0.62; p < 0.01 and the index of invasive procedures (R = 0.41; p < 0.01. Furthermore, the latter two indicators were significantly and positively correlated with the use of recently commercialised, broad spectrum antibacterial drugs (except for carbapenems. It is concluded that improved infection control procedures, together with more rigorous criteria regarding the use of invasive procedures, should be implemented by the ICU studied in order to diminish the utilisation of antibacterial drugs.

  15. Effects of a computerized provider order entry and a clinical decision support system to improve cefazolin use in surgical prophylaxis: a cost saving analysis

    Directory of Open Access Journals (Sweden)

    Okumura LM

    2016-09-01

    Full Text Available Background: Computerized Provider Order Entry (CPOE and Clinical Decision Support System (CDSS help practitioners to choose evidence-based decisions, regarding patients’ needs. Despite its use in developed countries, in Brazil, the impact of a CPOE/CDSS to improve cefazolin use in surgical prophylaxis was not assessed yet. Objective: We aimed to evaluate the impact of a CDSS to improve the use of prophylactic cefazolin and to assess the cost savings associated to inappropriate prescribing. Methods: This is a cross-sectional study that compared two different scenarios: one prior CPOE/CDSS versus after software implementation. We conducted twelve years of data analysis (3 years prior and 9 years after CDSS implementation, where main outcomes from this study included: cefazolin Defined Daily Doses/100 bed-days (DDD, crude costs and product of costs-DDD (cost-DDD/100 bed-days. We applied a Spearman rho non-parametric test to assess the reduction of cefazolin consumption through the years. Results: In twelve years, 84,383 vials of cefazolin were dispensed and represented 38.89 DDD/100 bed-days or USD 44,722.99. Surgical wards were the largest drug prescribers and comprised >95% of our studied sample. While in 2002, there were 6.31 DDD/100 bed-days, 9 years later there was a reduction to 2.15 (p<0.05. In a scenario without CDSS, the hospital would have consumed 75.72 DDD/100 bed-days, which is equivalent to USD 116 998.07. It is estimated that CDSS provided USD 50,433.39 of cost savings. Conclusion: The implementation of a CPOE/CDSS helped to improve prophylactic cefazolin use by reducing its consumption and estimated direct costs.

  16. Coronary grafts flow and cardiac pacing modalities: how to improve perioperative myocardial perfusion.

    LENUS (Irish Health Repository)

    D'Ancona, Giuseppe

    2012-02-03

    OBJECTIVE: Aim of this study was to investigate modifications of coronary grafts flow during different pacing modalities after CABG. MATERIALS AND METHODS: Two separate prospective studies were conducted in patients undergoing CABG and requiring intraoperative epicardial pacing. In a first study (22 patients) coronary grafts flows were measured during dual chamber pacing (DDD) and during ventricular pacing (VVI). In a second study (10 patients) flows were measured during DDD pacing at different atrio-ventricular (A-V) delay periods. A-V delay was adjusted in 25 ms increments from 25 to 250 ms and flow measurements were performed for each A-V delay increment. A transit time flowmeter was used for the measurements. RESULTS: An average of 3.4 grafts\\/patient were performed. In the first study, average coronary graft flow was 47.4+\\/-20.8 ml\\/min during DDD pacing and 41.8+\\/-18.2 ml\\/min during VVI pacing (P = 0.0004). Furthermore average systolic pressure was 94.3+\\/-10.1 mmHg during DDD pacing and 89.6+\\/-12.2 mmHg during VVV pacing (P = 0.0007). No significant differences in diastolic pressure were recorded during the two different pacing modalities. In the second study, maximal flows were achieved during DDD pacing with an A-V delay of 175 ms (54+\\/-9.6 ml\\/min) and minimal flows were detected at 25 ms A-V delay (38.1+\\/-4.7 ml\\/min) (P=ns). No significant differences in systolic or diastolic blood pressure were noticed during the different A-V delays. CONCLUSION: Grafts flowmetry provides an extra tool to direct supportive measures such as cardiac pacing after CABG. DDD mode with A-V delay around 175 ms. should be preferred to allow for maximal myocardial perfusion via the grafts.

  17. Brain natriuretic peptide as a predictor of heart failure in patients with permanent pacemaker

    Directory of Open Access Journals (Sweden)

    Jelić Vera

    2007-01-01

    Full Text Available Introduction: Brain natriuretic peptide (BNP has a role in control of cardiovascular and renal functions. Objective The objective was to assess the predictive value of BNP levels for development of heart failure in patients with permanent pacemakers. Method In patients with implanted DDD pacemakers, BNP levels were measured at rest and after exercise testing, on DDD and VVI modes. There were 42 patients (25 males; 59.5%, without symptoms or signs of coronary disease or heart failure, and with normal echocardiograms. According to BNP levels, the patients were divided into three groups: with BNP levels lower than 80 pg/ml, BNP ranging from 81-150 pg/ml, and BNP levels over 151 pg/ml. Results In the first group (27 patients, BNP levels were significantly higher on VVI compared to DDD mode, both at rest and after exercise (p<0.01, with all BNP levels within normal range. In the second group (5 pts, BNP levels at rest were also significantly higher on VVI than on DDD mode, p<0.05. After exercise, these values were also higher on VVI compared to DDD mode, but without statistical significance. The third group (10 pts as a whole had higher BNP values on VVI compared to DDD mode, with no statistical significance. In patients from this group who later developed heart failure, BNP levels were found to be significantly lower on DDD as opposed to VVI mode at rest, p<0.05, and even higher significance was found after exercise, p<0.01. After 6-year follow-up, 2 out of 5 patients from the second group developed dilated cardiomyopathy, and 8/10 patients in the third group experienced heart failure with LV EF 34.1±10%, LV EDD 6.1±0.42 cm, LV ESD 4.8±0.45 cm. Five of these patients died within the follow-up period. Conclusion The increased BNP levels can be valuable for early screening of patients with higher risk of heart failure. In patients with increased BNP at the time of pacemaker implantation, DDD pacing is a modality of choice.

  18. Antibacterial use in the Faroe Islands, Iceland, and Denmark 1999-2011

    DEFF Research Database (Denmark)

    Magnussen, Marita Debess; Gudnason, Thorolfur; Jensen, Ulrich Stab;

    2014-01-01

    . The objective was to describe, compare, and analyse the use of systemic antibacterial agents in these countries during the y 1999-2011. METHODS: Data were obtained from the Faroe Islands, Iceland, and Denmark on systemic antibacterial use and expressed in defined daily dosages (DDD). Prescription data were also...... obtained for specific age groups. RESULTS: The total antibacterial use for the y 1999-2011 varied markedly between the 3 countries, with a mean use of 21.8 DDD/1000 inhabitants/day (DID) in Iceland, 17.7 in the Faroe Islands, and 16.3 in Denmark. The total use remained fairly constant over the years...

  19. Embedding of Poly Honeycomb Networks and the Metric dimension of Star of David Network

    Directory of Open Access Journals (Sweden)

    F.Simonraj

    2013-01-01

    Full Text Available In this paper, we have introduced few Interconnection Networks, called David Derived Network DD(n ,Dominating David Derived Network DDD(n, Honeycomb cup Network HCC(n and Kite RegularTrianguline Mesh KRrTM(n. We have given drawing algorithm for DDD(n from Honeycomb networkHC(n and embedded poly–Honeycomb Networks, KRrTM(n in to Dominating David Derived Networks.Also we have investigated the metric dimension of Star of David network SD(n and lower bound of themetric dimension for DD(n.

  20. Impact of over-the-counter restrictions on antibiotic consumption in Brazil and Mexico.

    Directory of Open Access Journals (Sweden)

    Yared Santa-Ana-Tellez

    Full Text Available BACKGROUND: In Latin American countries over-the-counter (OTC dispensing of antibiotics is common. In 2010, both Mexico and Brazil implemented policies to enforce existing laws of restricting consumption of antibiotics only to patients presenting a prescription. The objective of the present study is therefore to evaluate the impact of OTC restrictions (2010 on antibiotics consumption in Brazil and Mexico. METHODS AND FINDINGS: Retail quarterly sales data in kilograms of oral and injectable antibiotics between January 2007 and June 2012 for Brazil and Mexico were obtained from IMS Health. The unit of analysis for antibiotics consumption was the defined daily dose per 1,000 inhabitants per day (DDD/TID according to the WHO ATC classification system. Interrupted time series analysis was conducted using antihypertensives as reference group to account for changes occurring independently of the OTC restrictions directed at antibiotics. To reduce the effect of (a seasonality and (b autocorrelation, dummy variables and Prais-Winsten regression were used respectively. Between 2007 and 2012 total antibiotic usage increased in Brazil (from 5.7 to 8.5 DDD/TID, +49.3% and decreased in Mexico (10.5 to 7.5 DDD/TID, -29.2%. Interrupted time series analysis showed a change in level of consumption of -1.35 DDD/TID (p<0.01 for Brazil and -1.17 DDD/TID (p<0.00 for Mexico. In Brazil the penicillins, sulfonamides and macrolides consumption had a decrease in level after the intervention of 0.64 DDD/TID (p = 0.02, 0.41 (p = 0.02 and 0.47 (p = 0.01 respectively. While in Mexico it was found that only penicillins and sulfonamides had significant changes in level of -0.86 DDD/TID (p<0.00 and -0.17 DDD/TID (p = 0.07. CONCLUSIONS: Despite different overall usage patterns of antibiotics in Brazil and Mexico, the effect of the OTC restrictions on antibiotics usage was similar. In Brazil the trend of increased usage of antibiotics was tempered after the OTC restrictions; in

  1. Follicular Dowling Degos disease: A rare variant of an evolving dermatosis

    Directory of Open Access Journals (Sweden)

    Saurabh Singh

    2013-01-01

    Full Text Available Dowling Degos disease is a rare, reticulate pigmentary disorder with variable phenotypic expression that manifests as hyperpigmented macules and reticulate pigmentary anomaly of the flexures. Many variants of this condition and its overlap with other reticulate pigmentary disorders have been reported in the literature. We present here two cases of DDD with follicular localization, both clinically and histologically. It was associated with ichthyosis vulgaris in one case. Follicular DDD is an uncommon variant of this evolving dermatosis. Our report supports the possible role for disordered follicular keratinisation in its pathogenesis.

  2. V. Tormis: "Bridge of Song / Brian Hunt

    Index Scriptorium Estoniae

    Hunt, Brian

    1997-01-01

    Uuest heliplaadist "V. Tormis: "Bridge of Song" - Bridge of Song; Singing aboard ship; Brides Farewell; Kihnu Island Wedding Songs; 17 Estonian Wedding Songs; Three Estonian Game Songs; Four Estonian Lullabies. Estonian Radio Choir / Toomas Kapten. Finlandia 4509 96937-2; 56:52 DDD; "People of Kalevala" - God protect us from war; Vespian Winter; Eagle Flew From the North East; Plague Memory; Vainamoinen's Words of Wisdom; The Seventeenth Rune of Kalevala. National Male Choir of Estonia. Finlandia 0630 12245-2; 56:52 DDD

  3. Recent Progress in Discrete Dislocation Dynamics and Its Applications to Micro Plasticity

    KAUST Repository

    Po, Giacomo

    2014-09-27

    We present a self-contained review of the discrete dislocation dynamics (DDD) method for the numerical investigation of plasticity in crystals, focusing on recent development and implementation progress. The review covers the theoretical foundations of DDD within the framework of incompatible elasticity, its numerical implementation via the nodal method, the extension of the method to finite domains and several implementation details. Applications of the method to current topics in micro-plasticity are presented, including the size effects in nano-indentation, the evolution of the dislocation microstructure in persistent slip bands, and the phenomenon of dislocation avalanches in micro-pillar compression.

  4. V. Tormis: "Bridge of Song / Brian Hunt

    Index Scriptorium Estoniae

    Hunt, Brian

    1997-01-01

    Uuest heliplaadist "V. Tormis: "Bridge of Song" - Bridge of Song; Singing aboard ship; Brides Farewell; Kihnu Island Wedding Songs; 17 Estonian Wedding Songs; Three Estonian Game Songs; Four Estonian Lullabies. Estonian Radio Choir / Toomas Kapten. Finlandia 4509 96937-2; 56:52 DDD; "People of Kalevala" - God protect us from war; Vespian Winter; Eagle Flew From the North East; Plague Memory; Vainamoinen's Words of Wisdom; The Seventeenth Rune of Kalevala. National Male Choir of Estonia. Finlandia 0630 12245-2; 56:52 DDD

  5. Neural Differentiation of Human Umbilical Cord Mesenchymal Stem Cells by Cerebrospinal Fluid

    Directory of Open Access Journals (Sweden)

    Shirin FARIVAR*

    2015-01-01

    chick embryos. J Exp Zool A Comp Exp Biol 2004 Apr 1;301(4:280-9.Mitchell KE, Weiss ML. Matrix cells from Wharton’s jelly form neurons and glia. Stem Cells 2003;21(1:50-60.Marcus AJ, Woodbury D. Fetal stem cells from extra-embryonic tissues: do not discard. J Cell Mol Med 2008 Jun;12(3:730-42. doi: 10.1111/j.1582- 4934.2008.00221.x. Epub 2008 Jan 11.Miao Z, Jin J, Chen L, Zhu J, Huang W, Zhao J, Quian H, Zhang X. Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells. Cell Biol Int 2006 Sep;30(9:681-7. Epub 2006 Apr 22.In ‘tAnker PS, Scherjon SA, Kleijburg-van der Keur C, Noort WA, Claas FHJ, Willemze R, Fibbe WE, Kanhai HHH. Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation. Blood 2003;102(4:1548-49.Magatti M, De Munari S, Vertua E, Gibelli L, Wengler GS, Parolini O. Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities. Stem Cells 2008 Jan;26(1:182-92. Epub 2007 Sep 27.Kang XQ, Zang WJ, Bao LJ, Li DL, Xu XL, Yu XJ. Differentiating characterization of human umbilical cord blood-derived mesenchymal stem cells in vitro. Cell Biol Int 2006 Jul;30(7:569-75. Epub 2006 Mar 6.Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006 May;24(5:1294-301. Epub 2006 Jan 12.Wagner W, Wein F, Seckinger A, Frankhauser M, Wirkner U, Krause U, et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 2005 Nov;33(11:1402-16.Jackson JS, Golding JP, Chapon C, Jones WA, Bhakoo KK: Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study. Stem Cell Res Ther 2010 Jun 15;1(2:17. doi: 10.1186/scrt17.Romanov YA, Svintsitskaya VA, Smirnov VN. Searching for alternative

  6. Searching for Roots. Pärt: Symphony No. 1, "Polyphonic" / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1997-01-01

    Uuest heliplaadist "Searching for Roots. Pärt: Symphony No. 1, "Polyphonic". Nekrolog, Op. 3; Tubin: Symphony No. 11; Tüür: Searching for Roots. Insula deserta. Zeitraum. Royal Stockholm Philharmonic Orchestra / Paavo Järvi. Virgin Classics VC5 45212-2 (72 min.:DDD)

  7. Bruckner: Simfonie N8 c-moll, London Philharmonic Orchestra, Neeme Järvi / Martin Elste

    Index Scriptorium Estoniae

    Elste, Martin

    1990-01-01

    Uuest heliplaadist "Bruckner: Simfonie N8 c-moll; Reger: Variationen und Fuge über ein Thema von Beethoven op. 86. London Philharmonic Orchestra, Neeme Järvi". Chandos/ Koch Records 2 CD 8843/44 (WD: 107'13") DDD

  8. Drug Utilization Study on Antimicrobial Use in Urinary Tract Infection

    Directory of Open Access Journals (Sweden)

    Sunil S Gidamudi

    2015-09-01

    Conclusion: The DDD/1000inhabitant/day of ceftriaxone was the highest (12.9. Third generation cephalosporins were used as first line drug in most cases. This group should be reserved for complicated UTIs. [Natl J Med Res 2015; 5(3.000: 216-221

  9. Sibelius. Lemminkäinen-Legenden op. 22 Nr. 1-4 / Christoph Schlüren

    Index Scriptorium Estoniae

    Schlüren, Christoph

    1997-01-01

    Uuest heliplaadist "Sibelius: Lemminkäinen-Legenden op. 22 Nr. 1-4, Nächtlicher Ritt und Sonnenaufgang op. 55, Luonnotar op. 70. Stockholm Philharmoniker / Paavo Järvi. Virgin/EMI CD 545213 2 (WD:70'22")DDD

  10. Chlorpromazine equivalents versus defined daily doses : How to compare antipsychotic drug doses?

    NARCIS (Netherlands)

    Rijcken, CAW; Monster, TBM; Brouwers, JRBJ; de Jong-van den Berg, LTW

    2003-01-01

    Classic chlorpromazine (CPZ) equivalents can be used to chart relative antipsychotic potencies of antipsychotic drugs. Values of CPZ equivalents per drug are ambiguous in literature. In drug use evaluation studies, antipsychotic doses are frequently compared by use of the defined daily dose (DDD). T

  11. Use of antibiotics in a hospital from 2006 to 2007%2006~2007年我院住院病人抗菌药物应用情况分析

    Institute of Scientific and Technical Information of China (English)

    刘卓; 盖兰萍

    2009-01-01

    目的 分析我院抗菌药物的使用情况及其变化趋势,促进医院的合理用药水平,为我院抗菌药物合理应用提供依据.方法 回顾性研究,收集2006年~2007年我院住院病人抗菌药物使用数据,以限定日计量(DDD)、用药频度(DDDS)、DDD/100人天及各类抗菌药物所占该年用药总量的百分比分析2年来我院住院患者抗菌药物使用情况.结果 两年来我院年消耗抗菌药物总量和使用频度均有所下降,DDD/100人天值分别为58.6,51.8;抗菌药物使用级别下降,用药频度较高的抗菌药物为头孢菌素类、青霉素类.结论 抗菌药物DDD/100人天的值趋于理想值,说明我院对抗菌药物的管理工作已有成效.

  12. An additional measure for quantifying antibiotic use in hospitals.

    NARCIS (Netherlands)

    Filius, P.M.; Liem, T.B.; Linden, P.D. van der; Janknegt, R.; Natsch, S.S.; Vulto, A.G.; Verbrugh, H.A.

    2005-01-01

    OBJECTIVES: The number of defined daily doses (DDD) per 100 patient days is often used as an indicator for the selection pressure exerted by antibiotics in the hospital setting. However, this unit of measurement does not fully describe the selection pressure and is sensitive to changes in hospital r

  13. Pärt, Arvo: De profundis. Missa Sillabica. Solfeggio / Marc Rochester

    Index Scriptorium Estoniae

    Rochester, Marc

    1997-01-01

    Uuest heliplaadist "Pärt, Arvo: De profundis. Missa Sillabica. Solfeggio. And one of the Pharisees. Cantate Domino. Summa. Seven Magnificat Antiphons. The Beautitudes. Magnificat. Christopher Bowers-Broadbent (org.), Daniel Kennedy (perc.). Theatre of Voices / Paul Hillier (bass). Harmonia Mundi HMU40 7182; HMU90 7182 (76 minutes:DDD)"

  14. Pärt, Arvo: De profundis / Barry Witherden

    Index Scriptorium Estoniae

    Witherden, Barry

    1997-01-01

    Uuest heliplaadist "Pärt, Arvo: De profundis. Missa Sillabica. Solfeggio. And one of the Pharisees. Cantate Domino. Summa. Seven Magnificat Antiphons. The Beautitudes. Magnificat. Christopher Bowers-Broadbent (org.), Daniel Kennedy (perc.). Theatre of Voices / Paul Hillier (bass)". Harmonia Mundi HMU40 7182; HMU90 7182 (76 minutes:DDD)

  15. Stem-cell treatment in disc degeneration: What is the evidence?

    Directory of Open Access Journals (Sweden)

    Manuela Peletti-Figueiró

    2013-01-01

    Full Text Available To review the potential role of stem cells in treating degenerative disc disease of the intervertebral disc (IVD. A review was performed of articles from the Medline database concerning stem cells and degenerative disc disease (DDD. To discuss the data, the papers were classified as: review, in vitro, experimental, and clinical. The currently available treatments were basically for symptom reduction, not to revert the IVD degenerative process. The use of mesenchymal stem cells (MSC is being proposed as an option of treatment for DDD. In vitro studies have shown that the MSC are able to differentiate into NP cells and that the MSC also reduce the inflammatory levels of the degenerated IVD. Besides, experimental studies demonstrated that the MSC remained viable when injected into the IVD, and that they were able to regenerate partially from the degenerated IVD and its structure. The few clinical studies found in the literature presented diverging results. The use of MSC is being widely studied and shows promising results for the treatment of DDD. Although many advances are being achieved in studies in vitro and experimental, there is a lack of clinical studies to prove the role of MSC in DDD management.

  16. Liszt. Concertos for Piano and Orchestra / Bryce Morrison

    Index Scriptorium Estoniae

    Morrison, Bryce

    1993-01-01

    Uuest heliplaadist "Pärt: Te Deum. Silouans Song. "My soul yearns after the Lord...". Magnificat. Berliner Messe. Estonian Philharmonic Chamber Choir, Tallinn Chamber Orchestra/Tõnu Kaljuste." ECM New Series 439 162-2 (66 minutes: DDD). Texts and translations included

  17. Searching for Roots. Pärt: Symphony No. 1, "Polyphonic" / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1997-01-01

    Uuest heliplaadist "Searching for Roots. Pärt: Symphony No. 1, "Polyphonic". Nekrolog, Op. 3; Tubin: Symphony No. 11; Tüür: Searching for Roots. Insula deserta. Zeitraum. Royal Stockholm Philharmonic Orchestra / Paavo Järvi. Virgin Classics VC5 45212-2 (72 min.:DDD)

  18. Pacer Calibration of F-16D USAF Serial Number 87-0391 (Project Pace Maker)

    Science.gov (United States)

    2010-06-01

    1 (Continued). DAS Data Parameters DAS Parameter Description *IRIG_TIME IRIG TIME (DDD:HH:MM:SS.S) LOAD_CELL LOAD_CELL NZ NZ FROM FC P_A_SYS1...HUD heads up display --- IAW in accordance with --- ICP Instrument control panel --- IRIG time Inter-range instrumentation group time --- JON

  19. The outpatient use of beta lactam antibiotics in Montenegro before the introduction of new reform strategy on drug market

    Directory of Open Access Journals (Sweden)

    Duborija-Kovačević Nataša

    2006-01-01

    Full Text Available Introduction: The study represents the first investigation of outpatient use of beta lactam antibiotics in Montenegro carried out in accordance with internationally approved methodology (DDD/ATC. Objective: The objective of our study was to establish both the scope and overall use of beta lactam antibiotics, and to assess their compatibility with current pharmacotherapeutic guidelines and their use in developed countries. Methods: The retrospective pharmaco-epidemiological study comprised a 100%-sample of beta lactams that were used in the period prior to introduction of new reform strategy on drug market. Results: Beta lactam antibiotics (J01C, J01D were the most frequently applied anti-infectives for systemic use (ATC group J in 2000 (11.3 DDD/1000 inh./day, 61%. Penicillins (J01C were the most utilized (8.0 DDD/1000 inh./day, 71%. Cephalosporin derivatives (cephalexin and cefaclor accounted for the remaining 29% (3.3 DDD/1000 inh./day. Aminopenicillins were prevailing among penicillins (85%. Beta lactamase sensitive penicillins were in the second place and approximately accounted for 14%. Conclusion: The results of our study showed that the use of beta lactam antibacterials could be estimated as partially satisfactory. There is a need to make additional efforts with a view of further rationalization.

  20. Does a computerized price comparison module reduce prescribing costs in general practice?

    DEFF Research Database (Denmark)

    Vedsted, Peter; Nielsen, Jørgen Nørskov; Olesen, Frede

    1997-01-01

    OBJECTIVE: We aimed to assess the trends in prescribed defined daily doses (DDD) and drug expenses before and after the introduction of a computerized cost containment module into the computer record system of a defined group of GPs. The GPs' expectations for and experiences with the module were...