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Sample records for hertzberger giuseppe serazzi

  1. Giuseppe Costantino (1937-2015).

    Science.gov (United States)

    Flanagan, Rosemary; Primavera, Louis H; Costantino, Erminia

    2016-01-01

    Giuseppe Costantino was born in Nocera Terinese, Italy, on December 25, 1937. Giuseppe's personal understanding of the immigrant experience infused his career. He developed Cuento therapies, hero/heroine therapy for adolescents, and the Tell-Me-a-Story (TEMAS) tests, which addressed the growing needs of multiculturalism. He served as a junior lieutenant/training officer in the Italian Armed forces, obtained his teaching degree (1955). Costantino immigrated to the United States in 1961. He earned a bachelor's degree in industrial psychology from Baruch College, a master's degree in school psychology from City College, and a doctorate in clinical/community psychology from New York University in 1975. Giuseppe began his career as a caseworker. The bulk of his career was spent in Brooklyn, New York, where he was chief psychologist for 7 years, clinical director for 21 years, and director of research, training, and new programs from 2005 until his death. Giuseppe, a psychologist who dedicated his life to working for minority populations, particularly children, died on February 18, 2015.

  2. Un ricordo di Giuseppe Pontiggia

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    Nanni Cagnone

    2014-07-01

    Full Text Available Segue la testimonianza su Giuseppe Pontiggia nel partecipato ricordo del poeta e narratore Nanni Cagnone. Sfiorando letteratura, filosofia, storia, filologia attraverso il richiamo alle conversazioni tra i due amici, si restituiscono i contorni culturali e soprattutto umani dello scrittore.

  3. Giuseppe Sergi, "champion" of Darwinism?

    Science.gov (United States)

    Volpone, Alessandro

    2011-01-01

    The Italian anthropologist, psychologist and evolutionist Giuseppe Sergi (1841-1936) may be regarded in some respects today as an "atypical" Darwinist, but, almost paradoxically, he was considered a "champion" of Darwinism by colleagues and commentators of his own time. Probably, two aspects of his work are responsible for this apparent anomaly: his faith in the so-called soft inheritance and his claims regarding a theory concerning the polyphyletic origin of human races. The soft inheritance theory, however, was needed by Sergi to support ideas regarding the complexity of inheritance in man, a fact that, in his opinion, could not completely be put down to mechanical laws, and polygeny was useful when trying to rectify the problem concerning the incompleteness of the fossil record. In both cases, it is possible to show that he was involved in supporting Darwinian theory during the most severe crisis of its consensus in Italy and at International level, between the end of the 19th century and the beginning of the 20th. Finally, the apparent unorthodox features which can be found in Sergi's ideas appear to be, in Kuhnian terms, ad hoc hypotheses put forward by Sergi himself in order to support the paradigm.

  4. Giuseppe Levi: mentor of three Nobel laureates.

    Science.gov (United States)

    Bentivoglio, Marina; Vercelli, Alessandro; Filogamo, Guido

    2006-12-01

    Giuseppe Levi (1872-1965), Professor of Anatomy at the University of Turin, had broad research interests and was a pioneer of in vitro studies on cultured cells. He provided a number of contributions on the nervous system, especially on the plasticity of sensory ganglion cells. An influential and magnetic teacher and mentor, he gathered around him a large group of brilliant students. He has the peculiar primate to count among his students three Nobel laureates in Physiology or Medicine: Salvador Luria, Renato Dulbecco, and Rita Levi-Montalcini. For all three of them, the internship in Levi's laboratory provided an exceptional initial stimulus. They remained in close contact with each other and with Levi even after the 1940s when they migrated to the United States for political and racial reasons, engaging in different fields of research. Rita Levi-Montalcini, who was awarded the Nobel Prize (1986) for the discovery of Nerve Growth Factor, was stimulated and assisted in her work by Giuseppe Levi during the difficult years of World War II. With Giuseppe Levi, she pursued early studies on the relationships between neural centers and their peripheral target of innervation, and she has witnessed in her writings the enthusiasm of her mentor.

  5. Giuseppe Cafiero sulle orme di Joyce a Roma

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    Carla De Petris

    2011-08-01

    Full Text Available In 2006 Giuseppe Cafiero published James Joyce, Roma & altre storie, a novel with thriller-like undertones that weaves stories around the author of Ulysses. In her conversation with the author, Carla de Petris investigates the genesis of the novel and reflects on the post-modernist stances of its complex plot.

  6. Maria and Giuseppe: lives intertwined with CERN’s history

    CERN Document Server

    Pauline Gagnon

    2014-01-01

    CERN will be celebrating its 60th anniversary this year. That means 60 years of pioneering scientific research and exciting discoveries. Two Italian physicists, Maria and Giuseppe Fidecaro, remember nearly all of it since they arrived in 1956. Most impressively, they are still hard at work, every day!   Giuseppe and Maria Fidecaro in Restaurant No. 1, at CERN, in 2014, 60 years after they joined the Organization. The couple is easy to spot, even in the cafeteria during busy lunchtimes, where they usually engage in the liveliest discussions. “We argue quite a lot,” Maria tells me with a big smile. “We have very different styles.” “But in general, in the end, we agree,” completes Giuseppe. In October 1954, Giuseppe went to the University of Liverpool as a CERN Fellow to do research at its brand new synchrocyclotron. Maria also joined, having obtained a fellowship from the International Federation of University Women. After getting m...

  7. Giuseppe Tinè, Erich Auerbach. Una teoria della letteratura

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    Riccardo Castellana

    2013-12-01

    Full Text Available Quello di Giuseppe Tinè è, in Italia, uno dei primi studi complessivi sull’autore di Mimesis e il suo sottotitolo, Una teoria della letteratura, non nasconde un’ambizione di completezza e di sintesi. Non si tratta qui, tuttavia, di una trattazione sistematica di quella teoria “diluita” nella pratica che ha contraddistinto l’attività di Auerbach ma piuttosto di un generoso, e per molti versi riuscito, tentativo di riconsiderare sub specie filosofica i fondamenti del suo metodo e, meglio ancora, della sua filosofia della storia. 

  8. Ferdinand Augustin Hallerstein on Giuseppe Castiglione`s Art

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    Nataša VAMPELJ SUHADOLNIK

    2015-12-01

    The present paper will focus on Hallerstein’s letters and what they tell us about the life and art of the celebrated Jesuit painter, Giuseppe Castiglione (1688–766, especially during the reign of the Emperor Qianlong (1711–799. After a brief  introduction on Hallerstein’s life and work, by means of comparative analyses and using an interdisciplinary approach, the paper will explore a Hallerstein’s views on Castiglione and his art, and b Chinese court painting and Castiglione’s position at the court. It will conclude with new evidence concerning Castiglione’s artistic achievements.

  9. Giuseppe Pontiggia and parody: Vite di uomini non illustri

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    Cristina Nesi

    2016-11-01

    Full Text Available «Tutto, in natura, ha un'essenza lirica, un destino tragico, un'esistenza comica», è l'esergo di Santayana scelto da Giuseppe Pontiggia per Vite di uomini non illustri (1993, parodia di un Dizionario biografico. Lo scrittore racconta diciotto esistenze con proteiformi modalità parodiche, che spaziano dalla comicità alla serietà, dai toni leggeri alla destabilizzazione del genere letterario. Una delle diciotto storie, Una goccia nell’oceano divino, verrà liberamente riutilizzata da Mario Monicelli in Facciamo paradiso.

  10. Il grande complotto televisivo: Giuseppe Genna, Dies Irae (2006)

    OpenAIRE

    Milanesi, Claudio

    2012-01-01

    Giuseppe Genna (1969-), scrittore, poeta, critico letterario, pubblicista, la cui produzione può essere seguita sui siti (Clarence, I Miserabili, Carmilla On Line, GiuGenna) con cui collabora o che cura personalmente, ha finora pubblicato 8 romanzi, più una serie di scritti di varia natura (raccolte di saggi, recensioni, instant book). Dei 7 romanzi, 4 formano la serie noir dell’ispettore Lopez. Nei quattro romanzi successivi al ciclo – L’anno luce (2005), Dies Irae (2006), Medium. Una storia...

  11. Giuseppe Pasta (1742-1823): protophysician and pioneer of psychological studies in the medical field.

    Science.gov (United States)

    Clerici, Carlo Alfredo; Veneroni, Laura; Poli, Marco

    2009-11-01

    Giuseppe Pasta was a pioneer of psychological support in physical disease. Born in Bergamo, Italy, he was a cousin of the physician Andrea Pasta who was a pupil of Giovanni Battista Morgagni. Giuseppe's cultural and clinical resources were the teachings of Francesco Redi's medical school in Tuscany. This paper discusses the courage and philosophical tolerance of disease and the etiquette of the physician.

  12. Mathematicians and the perfect language: Giuseppe Peano's case

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    Gouthier Daniele

    2002-03-01

    Full Text Available Attempts to create an International Artificial Language (IAL have kept pace with the evolution of modern science. Ever since Galileo’s time, scientists have been interested in how to create a perfect language (the adjective “perfect” takes on the meaning of “universal” or “unambiguous” depending on the period capable of supporting communication at a horizontal level i.e. within the scientific community, and at a vertical level, i.e. between scientists and the public. The first goal of this article is to describe briefly how this need for a perfect language developed over the past years. Special attention will be spent on the mathematicians’ role, especially Giuseppe Peano’s. The second goal is to illustrate how Giuseppe Peano’s contribution to this debate proved twofold and led to various conclusions. The Italian mathematician played a leading role in the creation of a perfect language, both at a horizontal and a vertical level. On the one hand, there is his successful attempt to introduce a standard logical and symbolic system of notation, which became essential for communication among mathematicians. On the other hand, there is the complete failure of his ambitious Latino sine flexione (Latin without inflection, a perfect language which died with its creator.

  13. Giuseppe Moscati: a man, a physician and a scientist.

    Science.gov (United States)

    Ponti, Giovanni; D'Onofrio, Felice; Ruini, Cristel; Muscatello, Umberto; Tomasi, Aldo

    2015-01-01

    The life of Giuseppe Moscati (1880-1927) as a man, as a physician and as a scientist may be framed within the cultural climate of Positivism, which spread over the last years of the 19th century and the beginning of the 20th Century. His activity contributed to patients' care improvement; in addition to meticulous drug regimens, he also prescribed a methodology of spiritual care, involving meditation and self-control as part of an holistic approach to healthcare. Our review deals with his published researches, highlighting the innovative findings on the juvenile diabetes treatment and extensive clinical changes consequent upon nephritis. This extraordinary man put considerable emphasis on primary care and holistic health in Italy, pioneering a new patient-centred, and holistic approach to medicine.

  14. Giuseppe Imbò and his contribution to volcano seismology

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    R. Schick

    1999-06-01

    Full Text Available Together with Fusakichi Omori and Kenzo Sassa, Giuseppe Imbò is one of the founders of volcano seismology. Imbò's novel idea in volcanic tremor analysis was the introduction of what he called "numeri indici dell'intensità eruttiva" (numerical indices of the eruptive intensity. It was one of the first attempts to quantify eruptive activity on the basis of seismic data. The indices permitted him to establish correlations at Mt. Vesuvius between seismic observations and eruptive phenomena. He found significant differences in the character of the recorded seismic signals between pre- and post-eruptive phases of effusive and explosive activity of the March 1944 eruption of Vesuvius. According to Imbò, volcanic tremors are the product of a rhythmic hammering caused by the degassing magma normal to the vertically-oriented walls of the feeding conduits.

  15. Giuseppe Antonino Biondo e la fondazione dell’International Recording

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    Paolo Biondo

    2015-08-01

    Full Text Available Giuseppe Antonino Biondo (1899-1988, a US citizen of Italian origins, was one of the most important entrepreneurs in the fields of discography and film sound post-production in Italy. A leading figure at American RCA, G.A. Biondo moved to Rome during the 1950s, where he founded RCA Italiana and, a few years later, International Recording, which became one of the main post-production companies in Italy until the 2000s. These operations deeply impacted on the technological and industrial setting of Italian cinema. In this essay we recall G.A. Biondo’s early years in the US and we deal with the chain of events that led to the birth of International Recording.

  16. POST-BIONIAN DEVELOPMENTS IN PSYCHOANALYTIC FIELD THEORY: THE CONTRIBUTIONS OF ANTONINO FERRO AND GIUSEPPE CIVITARESE.

    Science.gov (United States)

    Katz, S Montana

    2017-04-01

    The Bi-Personal Field: Experiences in Child Psychoanalysis. By Antonino Ferro. New York: Routledge, 1992 (1999). 232 pp. The Intimate Room: Theory and Technique of the Analytic Field. By Giuseppe Civitarese. New York: Routledge, 2008 (2010). 240 pp. The Necessary Dream: New Theories and Techniques of Interpretation in Psychoanalysis. By Giuseppe Civitarese; translated by Ian Harvey. London: Karnac, 2013 (2014). 246 pp. The Analytic Field and Its Transformations. By Antonino Ferro and Giuseppe Civitarese. London: Karnac, 2015. 224 pp. © 2017 The Psychoanalytic Quarterly, Inc.

  17. Tre voci per un Lexicon di Giuseppe Pontiggia

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    Daniela Marcheschi

    2014-07-01

    Full Text Available Tre parole-chiave offrono lo spunto per un’immersione nel pensiero e nell’opera di Giuseppe Pontiggia. La prima: parola, riaffermata dallo scrittore in quanto atto civile e ‘corporeo’ mediante il quale l’uomo fa esperienza di se stesso entrando in contatto con i suoi simili e con il circostante, ricongiungendosi insieme alla sua più profonda e antica natura. Viene così restituita allo scrittore/critico la responsabilità di lottare contro l’attuale minaccia dello svuotamento linguistico, nel nome di una costruttiva utopia culturale. La seconda parola, musica, serve a illuminare i romanzi di Pontiggia – in specie La grande sera e L’arte della fuga – attraverso suggestive analogie con la musica classica e il jazz, predilette dallo scrittore. Ossimoro è l’ultima voce di questo Lexicon: figura retorica, ma soprattutto figura conoscitiva che permette allo scrittore di scoprire la propria verità e il proprio linguaggio e al lettore di abbracciare una visione non lineare e problematica del mondo, capace di ampliare le prospettive e rinnovare lo sguardo.

  18. Giuseppe Sergi. The portrait of a positivist scientist.

    Science.gov (United States)

    Cerro, Giovanni

    2017-06-09

    Giuseppe Sergi (1841-1936) was one of the most important anthropologists and psychologists of the age of positivism and this article focuses on three domains of his scientific research: degeneration, eugenics and race. His concept of degeneration is defined as the development of special forms of human adaptation to the environment. This issue is closely related to his theory of the "stratification of character", which had a profound impact on Italian psychiatry and criminal anthropology in the late nineteenth century. Thus, special emphasis is placed on the differences between Sergi and Cesare Lombroso regarding their definitions of criminality and genius. Concerning eugenics, the article analyzes Sergi's key role in the Italian context, discussing his eugenic program based on both repression and education. His remedies against the spread of degeneration included not only radical and repressive measures, but also the improvement of popular education and the living conditions of the working class. In the field of physical anthropology, the article examines Sergi's morphological method of classifying ethnic groups. Although sharply criticized in Italy and abroad, this method had two major effects. First, it led to the definitive split between Sergi and Paolo Mantegazza and to the foundation of the Societá Romana di Antropologia in 1893. Second, it was the starting point for Sergi's theory of Mediterranean "stock", which claimed that European populations were of African origin in contrast to contemporary theories of Aryan supremacy. The article ends with a look at the heated debate over Sergi's Mediterraneanism during the period of Fascism.

  19. GIUSEPPE DE ROSA, Metodo per pianisti accompagnatori della danza, Milano, Suvini Zerboni, 2010

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    Chiara Sintoni

    2014-12-01

    Full Text Available Il volume di Giuseppe De Rosa è al contempo un agile metodo teorico-pratico per la formazione del pianista accompagnatore della danza classica e un sussidio didattico per la sua attività in situazione. Frutto dell’esperienza pluriennale dell’autore, colma un vuoto nella pubblicistica italiana dedicata all’argomento.

  20. Massimo De Giuseppe, La rivoluzione messicana, Bologna, Il Mulino, Universale Paperbacks, 2013, 248 p.

    OpenAIRE

    Traffano, Daniela

    2014-01-01

    Las conmemoraciones del bicentenario del proceso de Independencia y del centenario de la Revolución, que en México motivaron a lo largo del 2010 la difusión de discursos e imágenes, eventos políticos, culturales y deportivos así como la creación de espectáculos, videos y proyectos académicos, trascendieron el Atlántico y encontraron una voz y un espacio muy particulares en Italia, gracias a la última publicación del historiador Massimo De Giuseppe. Se trata de “La rivoluzione messicana”, un v...

  1. IL PROF. GIUSEPPE MOSCATI (1880-1927). RASSEGNA DELLA SUA PRODUZIONE SCIENTIFICA

    OpenAIRE

    2016-01-01

    Professor Giuseppe Moscati (1880-1927) was canonized by the Catholic Church in 1987. This act recognized the extraordinary qualities of a doctor who, considering his work as a “sublime mission”, dedicated his life to helping the sick. The fame of the “Holy doctor” or “doctor of the poor”, as people called him, was soon widespread and, immediately after his death, made him the subject of several biographies. These treatises, mainly written by religious hagiographers, have little analyzed Mosca...

  2. Bachelard, a present: au coeur de l’oeuvre de Giuseppe Penone

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    Manon Regimbald

    2012-10-01

    Full Text Available The perennial relevance of Bachelard’s poetic insight makes him a prophet for an age of ecological alienation. He clarifies the intuition of visual artists "since the 1960's", exemplified in the art of Giuseppe Penone, and their common “volonté de regarder à l’intérieur des choses.” How then does an artist such as Penone go from inside real things to arrive at this “intimité des substances” (Bachelard 1948 : 5. How do both men aspire to “l’immensité intime”?

  3. La forza in comune dei videogiochi. Giuseppe Frazzetto, Molte vite in multiversi. Nuovi media e arte quotidiana, Mimesis Edizioni, 2011

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    Federico Giordano

    2012-03-01

    Full Text Available Giuseppe Frazzetto insegna storia dell’arte contemporanea e discipline afferenti le nuove forme mediali presso l’Accademia di Belle Arti di Catania ed è fra i pochi in Italia ad accostare organicamente all’approccio umanistico nei confronti delle arti contemporanee, quello al videogioco. Questi interessi si esercitano chiaramente nel suo testo Molte vite in multiversi.

  4. Multivariate Modeling of the collaboration between Luigi Illica and Giuseppe Giacosa for the librettos of three operas by Giacomo Puccini

    NARCIS (Netherlands)

    Saccenti, E.; Tenori, L.

    2015-01-01

    This article explores the collaboration between the two Italian poets Luigi Illica and Giuseppe Giacosa that led to the librettos of three operas by Giacomo Puccini: La Bohème, Tosca, and Madama Butterfly. We used non-traditional authorship attribution methods (such as principal component analysis)

  5. Giuseppe Moruzzi: a tribute to a "formidable" scientist and a "formidable" man.

    Science.gov (United States)

    Levi-Montalcini, Rita; Piccolino, Marco; Wade, Nicholas J

    2011-01-07

    Giuseppe Moruzzi was born one century ago; he was an outstanding Italian neurophysiologist, who was particularly famous for his contributions to the study of the mechanisms underlying the control of the sleep-waking cycle in mammals. In 1990, Rita Levi-Montalcini, Moruzzi's great friend and admirer, used the occasion of an invitation by the University of Parma, where Moruzzi graduated in medicine in 1933, to celebrate Moruzzi's scientific achievements. She wished to pay a tribute to Moruzzi's human and ethical qualities by portraying him as a "perfect model" for the young generation wishing to pursue scientific research. The transcription of "Rita's" tribute to Moruzzi links two of the greatest figures of Italian neuroscience and also provides a lively account of how the personal histories of two promising young scientists intertwined with the great and tragic events of world history in the past century.

  6. "Nabucco" by Giuseppe Verdi: A Case of Delirium in an Italian Romantic Opera.

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    Cambioli, Luca; Bava, Mattia; Bellelli, Giuseppe; Clerici, Massimo; Cesana, Giancarlo; Riva, Michele Augusto

    2017-01-01

    Italian operas can provide relevant information on the medical knowledge during the Romantic Age, especially in the field of neuroscience. One of the most renowned operas, "Nabucco" by Giuseppe Verdi (1813-1901) may provide us with some information on the state of knowledge on neuropsychiatric diseases in the first part of the nineteenth century. The main character of this opera, the Assyrian king Nabucco suffers from delirium. Psychic signs and symptoms attributed to Nabucco in Verdi's opera could have been influenced by a better knowledge of neuropsychiatric diseases in the nineteenth century. Furthermore, the representation of Nabucco's mental illness in the opera could also have been influenced by direct experiences of Verdi himself, who seems to have suffered from recurrent depressive episodes in that period, and for the rest of his life. © 2017 S. Karger AG, Basel.

  7. [An illustrious unknown. Giuseppe Levi among science, anti-fascism and Nobel Prizes].

    Science.gov (United States)

    Grignolio, Andrea; De Sio, Fabio

    2009-01-01

    The anatomist Giuseppe Levi (1872-1965) is unanimously considered one of the major figures of Italian biomedical sciences in the 20th century. His fame, however, is mainly derived from having nurtured three Nobel Prize winners, namely Salvador E. Luria, Rita Levi Montalcini and Renato Dulbecco. In reappraising Levi's role in the development of Italian science and culture in general, this article aims at questioning both the narrowness of earlier accounts and a certain kind of genealogical approach to the history of scientific disciplines and academic schools. We will here consider Giuseppe Levi as an instance of two major cultural phenomena: the development of experimental biology in Italy and continental Europe and the anti-fascist socialist culture expressed by a part of the Italian intellectuals. In so doing, we will reassess the historical specificity of the scientific maturation of Levi's three famous students, on the one hand, while on the other we will consider in some depth the cultural and moral environment in which Levi thrived and his role as a moral example for his students. Such revision, we will argue, have a direct bearing on more general historiographical issues, namely, the need for a stronger contextualization of the birth and consolidation of research traditions, implying a rejection of simplistic genealogical reconstructions, and the role of academic schools and institutional settings in the definition of novel, multidisciplinary scientific approaches. Finally, the following will highlight the importance of a more careful outlook on the master-pupil relationship in academic context, addressing issues of both continuity and rupture. The article is subdivided in two main sections, the first devoted to Levi as a scientist, the second to his Anti-fascism.

  8. Giuseppe e i suoi fratelli: un progetto non realizzato di Luchino Visconti

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    Mauro Giori

    2011-06-01

    race a thorough story of this project and explains the reasons of its failure. Even if Visconti accepted De Laurentiis’s offer only to be sure that the producer would fund his adaptation of Camus’s The Stranger, Giuseppe e i suoi fratelli interested him because it gave him a second chance to work on the monumental version of Giuseppe’s story written by Thomas Mann. A few years before, Visconti had already written a treatment for Rocco e i suoi fratelli under the influence of this beloved novel, but he had abandoned every reference to it in the following development. Unfortunately, Christopher Fry, an American playwright and screenwriter also involved in the biblical project, failed to understand Visconti’s predilection for the novel and rejected any influence of the German writer. Despite Visconti’s efforts to find a compromise, the director’s conception of the story (and of cinema as well was too far from Fry’s one, as the three different screenplays written by them for the project show in an unmistakable way, and the director was dismissed by the producer without any notification.

  9. Macbeth by Giuseppe Verdi and the Romantic reception of William Shakespeare’s drama

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    Alina Borkowska-Rychlewska

    2010-01-01

    Full Text Available Romantic approach to William Shakespeare’s dramatic works, as well as the notions and questions so vital for the consciousness of the epoch concerning the capacity and function of destiny, unrecognizability of existence, interference of supernatural powers in the world that can be grasped with human mind and common sense, are all intriguingly transparent in Giuseppe Verdi’s Macbeth. The Italian composer, who knew the Romantic reception of Shakespeare’s dramatic plays well (e.g. the Italian translations of the lectures given by August W. Schlegel, embarked upon the issue of the ambiguity of the scene with the witches that appear to Macbeth, posed a question on the cognitive value in the dreamy apparition (in the brilliantly constructed Lady Macbeth’s sleepwalking scene, and, finally, emphasized the aspect of hybridity of the world that inseparably combines the grandeur and the grotesque (the point highlighted in Victor Hugo’s considerations on Shakespeare. The two versions of the operatic Macbeth — the one produced in Florence in 1847, the other, 1865 revised version produced for Paris — relate well with the long sequence of changeable conventions in the nineteenth century theatre, taking into consideration its requirements (the need for a spectacular character of staging, the introduction of multiple Ake a Romantic implant in the operetta world of farcical braggadocio dominant on the Parisian stage at the time of the Second Empire, testifies to the enormous influence of the Romantic reception of Shakespeare exerted at the time and defining for a considerable period of time the concept of adaptation of the works of the Stradford master to meet the needs of the operatic stage.

  10. [Prof. Giuseppe Moscati (1880-1927). A special issue on his scientific production].

    Science.gov (United States)

    Cascella, Marco

    2016-08-01

    Professor Giuseppe Moscati (1880-1927) was canonized by the Catholic Church in 1987. This act recognized the extraordinary qualities of a doctor who, considering his work as a "sublime mission", dedicated his life to helping the sick. The fame of the "Holy doctor" or "doctor of the poor", as people called him, was soon widespread and, immediately after his death, made him the subject of several biographies. These treatises, mainly written by religious hagiographers, have little analyzed Moscati as a doctor and scientist, or, in rare cases, privileged the description of his medical career, touching only marginally salient aspects of his work as a scientist and researcher. The purpose of this paper is to provide an insight into the figure of Moscati as a scientist, contextualizing his research activities in the scientific fields of biochemistry and physiology, which were flourishing in the early twentieth century. By a more careful analysis, his scientific production appears original for the resource-poor context and the innovative research method. The Italian scientist, combining physiological chemistry and biochemistry at the clinic, anticipated the birth of modern branches as the "Laboratory Medicine" and the "Clinical Pathology". In particular, he carried out studies on diabetes, storage diseases, metabolism, toxicology, pathology, nephrology and occupational diseases. Moreover, he anticipated the concept of modern laboratory in the oncological field as means for the characterization of the "nature" of neoplasms and related therapeutic approaches. Therefore, even if Moscati was rarely mentioned by the sources of the history of medicine, it is safe to assume that the fame of the Saint has paradoxically eclipsed that of the scientist, preventing him from receiving the necessary reward.

  11. Giuseppe and Maria Fidecaro inside the Spark Chamber Apparatus in the South Hall of PS to search for the $\\rho \\rightarrow \\pi\\gamma$ decay

    CERN Multimedia

    Gérard Bertin

    1964-01-01

    A year after the commissioning of the Synchrocyclotron (SC), the first experiments were already starting to bear fruit. In July 1958, Tito Fazzini, Giuseppe Fidecaro, Alec Merrison, Helmut Paul and Alvin Tollestrup produced conclusive evidence that approximately one pion in ten thousand decayed into an electron and a neutrino, as predicted by the weak interaction theory. This, the first of CERN's great discoveries, effectively put an end to the controversy that had been raging at the time. A few years later, Giuseppe Fidecaro began a collaboration at CERN with his wife Maria. In the image, Giuseppe and Maria Fidecaro in 1963, surrounded by spark chambers, inside the detector for the experiment on the decay of a rho meson into a pi meson and a photon.

  12. Voortgezet diagnostisch onderzoek naar een betere beheersing van een aantasting door de schimmel Colletotrichum acutatum bij de bollenteelt van tulpen cv. Giuseppe Verdi

    NARCIS (Netherlands)

    Vink, P.

    2008-01-01

    Sinds 1992 kennen we een ziekte bij de teelt van tulpen in metname de cultivar Giuseppe Verdi (en de laatste tijd ook wel eens in andere tulpencultivars) waarbij de bollen worden aangetast door de schimmel Colletotrichum acutatum. Daardoor gaan de bollen na de oogst verloren of groeien er in een vol

  13. Voortgezet diagnostisch onderzoek naar een betere beheersing van een aantasting door de schimmel Colletotrichum acutatum bij de bollenteelt van tulpen cv. Giuseppe Verdi

    NARCIS (Netherlands)

    Vink, P.

    2008-01-01

    Sinds 1992 kennen we een ziekte bij de teelt van tulpen in metname de cultivar Giuseppe Verdi (en de laatste tijd ook wel eens in andere tulpencultivars) waarbij de bollen worden aangetast door de schimmel Colletotrichum acutatum. Daardoor gaan de bollen na de oogst verloren of groeien er in een

  14. Un omaggio a Giuseppe Bellini attraverso un libro a lui dedicato: cuando quiero hallar las voces, encuentro con los afectos...

    Directory of Open Access Journals (Sweden)

    Emilia Perassi

    2015-01-01

    Full Text Available Il presente articolo si propone di tracciare il ritratto di uno dei grandi maestri di studi ispanoamericanistici, Giuseppe Bellini, attraverso una recente opera miscellanea a lui dedicata, a cura di Patrizia Spinato Bruschi e Jaime Martínez. Tale raccolta di saggi non solo restituisce le linee, i contenuti e le forme di una produzione critica monumentale ma ben mostra l’importante ruolo di studioso e di uomo che il Bellini è stato capace di esercitare, articolando attorno a sé una nutrita scuola, a partire dalla visione della letteratura come rete di dialogo e di scambio. I diversi temi affrontati dai più di cinquantacinque saggi mostrano la straordinaria capacità del Bellini di tessere una proficua rete di relazioni, di studio e di amicizia, e di promuovere l’ispanoamericanismo italiano, sempre attraverso il riconoscimento della letteratura come lezione civile e del buon vivere.

  15. Giuseppe E. Sansone traduttore di lirica romanza medievale. Contributo per una storia della traduzione poetica in Italia

    Directory of Open Access Journals (Sweden)

    Speranza Cerullo

    2013-07-01

    Full Text Available La traduzione di poesia medievale in Italia ha avuto notevole sviluppo negli ultimi venti anni, attraverso l’incremento dell’attività dei traduttori e la promozione di un confronto su questioni di ordine teorico o metodologico, strettamente legate al tema dell’attualizzazione del testo medievale. In questo quadro, il contributo di Giuseppe Sansone ha svolto un ruolo di primo rilievo, attraverso un’attività ininterrotta che conta la pubblicazione di scritti di indirizzo critico-teorico e di cinque antologie di lirica medievale di diversi ambiti linguistici – occitano, spagnolo, catalano, galego e, in misura minore, francese –, offrendo modelli e appunti di metodo nei quali competenze scientifiche e filologiche si coniugano con una sensibilità estetica d’autore, guidata dall’obiettivo primario di una rifondazione del testo poetico nella sua letterarietà, dove la traduzione in versi si propone come testo dotato di una propria autonomia estetica.Over the last twenty years the translation of medieval poetry in Italy has had considerable development due to the increased activity of the translators; besides, a debate on theoretical or methodological issues closely related to the theme of updating medieval texts has been promoted. In this context, the contribution of Giuseppe Sansone and his continuous activity has played a key role: he published critical-theoretical essays and five anthologies of medieval lyrics from different linguistic areas – Provençal, Spanish, Catalan, Galician and, to a lesser extent, French – thus offering models and methodological suggestions in which scientific and philological skills combine with aesthetic sensibility, driven from the primary method of re-founding the poetic text in its literary property, in which the verse translation is proposed as a text with its own aesthetic autonomy.

  16. Entre el Ejército del Comintern y la solidaridad antifascista: la trayectoria de Giuseppe Di Vittorio en el debate sobre la naturaleza de las Brigadas Internacionales

    Directory of Open Access Journals (Sweden)

    Josep PUIGSECH FARRÀS

    2011-05-01

    Full Text Available El debate historiográfico sobre la naturaleza de las Brigadas Internacionales durante la Guerra Civil Española de 1936-1939 se encuentra hoy día fracturado entre las tesis favorables a su sumisa supeditación a los intereses del partido-Estado Soviético y aquellas que apuestan por otorgarle un cierto grado de autonomía y una importante dosis de solidaridad. Sin embargo, este debate dispone de una nueva fuente de análisis gracias a la trayectoria de uno de los máximos dirigentes del citado cuerpo internacionalista, Giuseppe Di Vittorio. El histórico militante antifascista italiano generó una amplia y controvertida actividad durante los meses que estuvo presente en la República Española, entre octubre de 1936 y febrero de 1937. Así, ocupó el tercer lugar en el escalafón directivo de la sede española de las Brigadas Internacionales en Albacete, participó activamente en la defensa de Madrid, desarrolló una intensa capacidad propagandística para difundir las Brigadas Internacionales entre la población civil republicana, protagonizó diferentes conflictos políticos y personales con otros miembros del aparato brigadista y fue retirado del territorio republicano en extrañas circunstancias. Así, pues, su amplia y variada actividad al frente de las Brigadas Internacionales le convierte en un protagonista privilegiado para analizar la naturaleza de las Brigadas Internacionales.

  17. GIUSEPPE MAZZINI AND THE SOCIALISM

    Directory of Open Access Journals (Sweden)

    Remus TANASĂ

    2014-11-01

    The International was the playground of a skirmish between the three historical figures, an ideological debate on concepts like „private proprety”, „dialectical materialism” or „nationality”. The dispute was between Mazzini on one side, and Marx and Bakunin on the other, till 1868 when a cleavege was noticed even between the last two.

  18. Rendiconti finanziari e struttura di governo del Seminario di Siena in S. Giorgio durante la reggenza dell’Arcivescovo Giuseppe Mancini (1824-1855 = Financial reports and governance structure of s. Giorgio Seminary in Siena, during the Archbishop Giuseppe Mancini regency (1824-1855

    Directory of Open Access Journals (Sweden)

    Giussepe Caturi

    2016-06-01

    Full Text Available Este artículo tiene como objetivo investigar una particular dimensión cultural de una comunidad social: la religiosa. Su premisa básica es la idea que hay muchas correlaciones e interdependencias entre los diferentes aspectos de la cultura de un pueblo, por lo que los cambios en uno de ellos pueden causar cambios en todos los demás. Entonces, no se puede pensar la cultura religiosa de una comunidad como distante desde la económica y científica, porque cada uno de ellas tiene el ser humano como elemento central y original. Por otra parte, la dimensión religiosa es tan penetrante en el alma humana, que se puede considerar como algo que caracteriza una comunidad. En esta perspectiva, es muy importante la misión sacerdotal que requiere una formación específica que se puede adquirir a través de cursos de estudio impartidos en los “seminarios”. Estas entidades eclesiásticas constituyen nuestro objeto de estudio, con especial referencia a lo que, hasta hoy, ha operado en la Diócesis de Siena. La comunidad social de Siena es extraordinariamente atractiva por su historia política y administrativa, por su patrimonio artístico y cultural y, sobre todo, por el sentimiento religioso de su población, lo que ha generado muchos grandes santos como Catalina Benincasa y Bernardino. El estudio, con un enfoque económico-empresarial, se refiere al sistema de contabilidad y a la estructura de gobierno de la institución analizada. Considerado su historia turbulenta y llena de eventos, limitamos la investigación a un período significativamente interesante: la regencia diocesana del Arzobispo Giuseppe Mancini (1824-1855, cuando se estaban absorbiendo las supresiones leopoldinas y napoleónicas y el Seminario estaba en la Iglesia de San Jorge. Lo studio intende indagare su di una particolare dimensione culturale delle comunità sociali: quella religiosa. La sua premessa di base è la consapevolezza delle numerose correlazioni e interdipendenze

  19. At the occasion of 10th anniversary of the 3-week CERN High School Teacher Programme, the Director General and two guests of honour - Maria and Giuseppe Fidecaro - joined the 37 teachers from Europe, US, Latin America and Asia for a group photo.

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    At the occasion of 10th anniversary of the 3-week CERN High School Teacher Programme, the Director General and two guests of honour - Maria and Giuseppe Fidecaro - joined the 37 teachers from Europe, US, Latin America and Asia for a group photo.

  20. Sub anno domini 1465... In casa de’ figliuoli di Aldo. Origin and advancements of the printing press in Italy through the exemplars of the Bagnacavallo ‘Giuseppe Taroni’ library

    Directory of Open Access Journals (Sweden)

    Federica Fabbri

    2016-11-01

    Full Text Available The paper contains the descriptions of the ancient books owned by the Public Library ‘Giuseppe Taroni’ in Bagnacavallo, which were selected for the exhibition Sub anno domini 1465... In casa de’ figliuoli di Aldo to celebrate the printing of the first book in Italy by Konrad Sweynheym and Arnold Pannartz with datation included in the colophon (Subiaco, 1465 and the fifth centenary of Aldus Manutius’ death, the major Italian printer and publisher of the Renaissance age (1449-52?-1515. Among the exhibited copies the one belonging to the Roman edition of 1470 of the work of the Christian scholar Lactantius, the only one copy printed by Sweynheym and Pannartz owned by the Library in Bagnacavallo, and a selection of books printed by Aldus Manutius and his heirs, among which the only copy found in this library of a book printed by Aldus The Elder, belonging to Institutiones Grammaticae of 1514.

  1. Seminar in Flow Visualization at Lafayette College: Variations on the Hertzberg Effect

    Science.gov (United States)

    Rossmann, Jenn Stroud

    2013-11-01

    Flow visualization reveals an invisible world of fluid dynamics, blending scientific investigation and artistic exploration. The resulting images have inspired, and in some cases themselves become appreciated as, art. At Lafayette College, a sophomore-level seminar in The Art and Science of Flow Visualization exposes students to these techniques and the science of fluid mechanics, and to the photographic methods needed to create effective images that are successful both scientifically and artistically. Unlike other courses in flow visualization, this course assumes no a priori familiarity with fluid flow or with photography. The fundamentals of both are taught and practiced in a studio setting. Students are engaged in an interdisciplinary discourse about fluids and physics, photography, scientific ethics, and historical societal responses to science and art. Relevant texts from several disciplines are read, discussed, and responded to in student writing. This seminar approach makes flow visualization and fluid dynamics a natural part of a liberal education. The development, implementation, and assessment of this team-taught course at Lafayette College will be discussed. Support provided by National Science Foundation.

  2. Ka Aafrikas tehakse filme / Giuseppe Gariazzo

    Index Scriptorium Estoniae

    Gariazzo, Giuseppe

    2004-01-01

    Tallinna VIII Pimedate Ööde Filmifestivalil on fookuses postkoloniaalse Aafrika filmikunst. Artikkel käsitleb Mali ja Senegali, Burkina Faso ning Põhja-Aafrika (Maroko, Al̓eeria, Tuneesia ja Egiptus) filmindust

  3. Ka Aafrikas tehakse filme / Giuseppe Gariazzo

    Index Scriptorium Estoniae

    Gariazzo, Giuseppe

    2004-01-01

    Tallinna VIII Pimedate Ööde Filmifestivalil on fookuses postkoloniaalse Aafrika filmikunst. Artikkel käsitleb Mali ja Senegali, Burkina Faso ning Põhja-Aafrika (Maroko, Al̓eeria, Tuneesia ja Egiptus) filmindust

  4. The First Published History of Universal Architectural Models. Jean-Nicholas-Louis Durand’s Recueil et parallèle des édifices de tout genre, anciens et modernes (Paris 1800, and the Extended Italian Edition of Giuseppe Antonelli (Venice 1833

    Directory of Open Access Journals (Sweden)

    Vincenzo Fontana

    2014-06-01

    Full Text Available “Recueil et parallèle des édifices de tout genre, anciens et modernes”, published in Paris in 1799-1800 by Jean- Nicholas-Louis Durand, at the height of the positivistic climate engendered by the contemporary culture of encyclopedism, plays an important role in architectural historiography. The volume allowed architectural students and architectural enthusiasts alike the first opportunity to study a vast range of architectural design models of all periods and places organised into typological categories, illustrated in highly didactic and homogenous drawings. The immediate success of the “Recueil” was guaranteed by the simultaneous publication (in 1800 of an explanatory text to accompany the illustrative material, written by Jacques Guillaume Legrand in accordance with Durand. More than thirty years later, the Venetian editor Giuseppe Antonelli proposed a re-launch of the “Recueil” intended to meet the contemporaneous historical and critical context of modern Europe, publishing a bilingual Italian-French edition of highly commercially ambitious scope. The Venetian “Raccolta”, which appeared in 1833, united Legrand’s text with Durand’s illustrations, - and importantly included almost double the illustrations- with the addition of antique buildings, and also included modern architectural models, alongside contemporary Italian, French and German architectural design projects. This contribution intends to set Antonelli’s ambitious undertaking into the contemporaneous critical and vivacious academic cultural climate of the Venice of the 1830’s, and also includes a thorough examination of the additional illustrations that were added by the Venetian publisher to the original French canon.

  5. Letture gramsciane di Giuseppe Lombardo Radice (II parte

    Directory of Open Access Journals (Sweden)

    Pietro Maltese

    2012-06-01

    Full Text Available In Gramsci’s intellectual development is not a place on the periphery is occupied by the figure of Lombrado Root. Prominent character of pedagogy idealism and importer in Italy, activist of instances (even American, socialist “romantic, sentimental, unscientific.” Lombardo Radice was a careful student of the drama of the South and Gramsci was always very interested in the work of the Sicilian and there are many similarities (apparent between the two intellectuals: 1 the focus on popular culture, 2 the combination between educational and political problems, and 3 the reference to the figure of Leonardo and other similarities yet. The author has done a thorough research work and significant.

  6. Kes kardab poeete? / Giuseppe Provenzano ; tõlk. Katrin Tombak

    Index Scriptorium Estoniae

    Provenzano, Giuseppe

    2008-01-01

    Tallinna Harjumäele rajatavast Vabaduse monumendist, ummiku äärele jõudnud avalikust diskussioonist, monumendi tähendusest. Õnnestunud monument peab esmajoones puudutama meie hinge ja tal ei tohiks puududa ilu

  7. Giuseppe Garibaldi and Sweden: Between Solidarity and Scandinavism

    Directory of Open Access Journals (Sweden)

    Monica Quirico

    2008-03-01

    Full Text Available The book entitled Scandinavia: Her Fears and Her Hopes, written in French, was published on February 29, 1856, in Paris, where representatives of the European Powers were discussing peace negotiations with Russia ensuing the end of the Crimean War. The author, Gustaf Lallerstedt, a moderate liberal, a diplomat, and majority shareholder of the liberal newspaper "Aftonbladet", was first in outlining a parallelism between the proactive role played by Piedmont in Italy's unification and the similar one that Sweden, in his opinion, ought to take upon herself vis-à-vis Scandinavian unity. Lallerstedt's aim was also to warn the European nations against the Russian threat; in this perspective, strengthening the United Kingdom of Sweden and Norway (established in 1814 could provide an effective remedy.

  8. Kes kardab poeete? / Giuseppe Provenzano ; tõlk. Katrin Tombak

    Index Scriptorium Estoniae

    Provenzano, Giuseppe

    2008-01-01

    Tallinna Harjumäele rajatavast Vabaduse monumendist, ummiku äärele jõudnud avalikust diskussioonist, monumendi tähendusest. Õnnestunud monument peab esmajoones puudutama meie hinge ja tal ei tohiks puududa ilu

  9. Giuseppe Ros's Library%罗斯书库

    Institute of Scientific and Technical Information of China (English)

    神田喜一郎; 曹春玲; 胡素萍

    2011-01-01

    今年(1944年,译者注)二月末,我奉台湾总督府之命到广州出差,对驻广州意大利总领事罗斯的书库做了调查。罗斯收藏了为数众多的珍贵图书和标本,固这在很早以前就在我国的专业领域中广为人知,也有不少学者慕名前去拜访,然而毕竟是私人书库,迄今为止能有幸观摩到书库全貌的还没有一个人。罗斯也曾几度忍痛割爱,将书库的一部分珍藏品转卖出去,

  10. Un altro precursore di Francesco Scaduto: Giuseppe Ingoglia

    Directory of Open Access Journals (Sweden)

    Antonio Ingoglia

    2011-03-01

    Full Text Available Contributo destinato alla pubblicazione negli Atti del convegno su “Il contributo di Francesco Scaduto alla scienza giuridica” (Palermo, 18 -19 febbraio 2005 per i tipi della Cedam.SOMMARIO: 1. Premessa - 2. L’attività accademica – 3. Il metodo d’insegnamento - 4. Influenze sugli orientamenti enunciati dallo Scaduto. Conclusioni.

  11. The great composer Giuseppe Verdi and his opera“La Traviata”

    Institute of Scientific and Technical Information of China (English)

    陈珺

    2013-01-01

    The 19th century, Romanticism factors gradually penetrate into the development of Italian opera. The three: Rossini Donizetti, Bellini Development Italian belcanto tradition. Verdi is a master of 19th-century Italian Romantic opera. His opera "La Traviata" moving force its profound realism plays a transitional role in the devel-opment of European opera.

  12. Il silenzio delle api. L’universo femminile di Giuseppe Dessì

    Directory of Open Access Journals (Sweden)

    Piero Mura

    2015-07-01

    Full Text Available Il tempo delle donne in Dessì è sempre un tempo di attesa, un’attesa che dalla gravidanza quella maternità, in atto o in potenza, che sovente caratterizza i suoi personaggi femminili si estende all’intero arco della vita. Un’attesa che è di pietra, come l’Isola. Allo stesso modo mestiere degli uomini è il ritorno, reale o metaforico, tentato o riuscito, vano o proficuo, da tutte le guerre della vita. Ritorno alla donna, alla madre che è la Sardegna, utero e avello delle loro esistenze. Tali attese, nella narrativa dessiana, vengono raccontate dai silenzi più che dalle parole. Dal silenzio ostinato e ingombrante di Mariangela Eca ne Il disertore preghiera e insieme attitu muto alla contrapposizione fra la comprensione afasica della bimba protagonista del testo breve La mano della bambina che pronuncia, in tutto il racconto, una sola parola e l’ottusità verbosa della madre (che sembra suggerire che per comprendere non sono necessarie parole ma empatia, fino all’inquadramento sociale de La serva degli asini, che ricomincia a esistere come persona solo quando viene affrancata dal silenzio delle donne di casa, arma che uccide più che spada e lingua.

  13. Giuseppe Samonà historian of architecture: his relationship with Gustavo Giovannoni

    Directory of Open Access Journals (Sweden)

    Fabrizio Di Marco

    2014-12-01

    Full Text Available The essay is intended to highlight the links between Samonà and the "Roman School", in part already analyzed in previous studies. In particular, we contextualize the six letters addressed to Gustavo Giovannoni between late 1929 and mid-1930, preserved in the Giovannoni Archive (Rome, Centro di Studi per la Storia dell’Architettura and listed in full in the appendix. The letters are mainly related to the studies of Samonà on late Renaissance architecture in Sicily, conducted in 1927 at the suggestion of Ernesto Calandra, which would then be gathered into four essays published between 1932 and 1935, profoundly influenced by the historical-critical ‘giovannoniano’ method. The epistolary contacts with Giovannoni, as well as promoting cultural growth and the rise of the career of teaching, not well structured at the time, show his attempt to get closer to Rome. This is evidenced by repeated references in the letters to Alberto Calza Bini, who was to assist him in obtaining a position at the University of Naples and who, together with Giovannoni and Piacentini, ruled in favor of Samonà in design competitions in the thirties, especially for the Post Office building in the Appio neighborhood in Rome.

  14. Comment on Giuseppe Genchi et al. Mercury Exposure and Heart Diseases. Int. J. Environ. Res. Public Health 2017, 14, 74

    Directory of Open Access Journals (Sweden)

    S. M. J. Mortazavi

    2017-07-01

    Full Text Available Cenchi et al. [1] have recently published an article entitled “Mercury Exposure and Heart Diseases” that is published in Int. J. Environ. Res. Public Health 2017, 14, 74; doi:10.3390/ijerph14010074.[...

  15. The unfinished mechanics of Giuseppe Moletti an edition and English translation of his dialogue on mechanics, 1576

    CERN Document Server

    Laird, Walter, R

    2000-01-01

    Laird sets Moletti's Dialogue within the historical background of medieval and Renaissance mechanics, sketches the life and works of Moletti, and analyses the arguments and the geometrical theorems of the Dialogue.

  16. Not a geography of what doesn't exist, but a counter-geography of what does: Rereading Giuseppe Dematteis' Le Matafore della Terra

    NARCIS (Netherlands)

    Fall, J.J.; Minca, C.

    2013-01-01

    The shaping of geography as a discipline has been the result of a combination of productive and successful communication and missed opportunities, of presence and absence, of fluid travels of ideas and projects, but also of closures, impediments, good lessons that got lost. This paper suggests that

  17. Giuseppe Patota, Grammatica di riferimento della lingua italiana per stranieri, Società Dante Alighieri; Firenze, Le Monnier, 2003; 424 pp.

    Directory of Open Access Journals (Sweden)

    Pavao Tekavčić

    2004-12-01

    Full Text Available Fra le tante grammatiche della lingua italiana pubblicate finora quella che qui recensiamo occupa un posto particolare grazie a certe qualità che mettteremo in rilievo, naturalmente in modo succinto, date le dimensioni della recensione.L'autore, professore all'Atteneo di Siena, ha pubblicato ultimamente alcuni titoli di carattere divulgativo (si veda la copertina anteriore interna e l'opera presente continua quest'attività, tanto utile quanto importante per quanti si dedicano all'i­taliano.

  18. Il “modello emiliano” da Giuseppe Dozza a Pier Luigi Bersani. Video-saggio tra comunicazione e propaganda politica (1946–2013

    Directory of Open Access Journals (Sweden)

    Sante Cruciani

    2014-01-01

    Full Text Available Nella storia dell’Italia repubblicana, il “modello emiliano” ha costituito la carta d’identità dell’azione riformatrice dei comunisti nel governo locale e regionale. La fortuna internazionale di questa esperienza ha accompagnato le strategie del “compromesso storico” e dell’“eurocomunismo” e il dialogo tra il Pci e la sinistra europea. Questo video si sofferma sulla costruzione mediatica del “modello emiliano”.

  19. Recommendations

    DEFF Research Database (Denmark)

    Baumeister, Ruth

    2016-01-01

    This article discusses three book publications: C. Kerez: Uncertain Certainty, Tokyo, 2013 H. Hertzberger: Lessons for students in architecture, Rotterdam, 2006, (1991) A. Jorn: Om Formen, Silkeborg, 2014, (1958)...

  20. Download this PDF file

    African Journals Online (AJOL)

    TNHJOURNALPH

    ... estrogen cream. Two out of the eleven patients who needed surgical treatment were not done due to ... mucosal redundancy.10 These factors lead to .... common theory is that the problem arises as a .... Anveden-Hertzberg L, Gauderer MW,.

  1. URETHRAL PROLAPSE: A CASE REPORT AND

    African Journals Online (AJOL)

    mains unknowns. Several theories explaining ... both congenital and acquired factors. The ... The more popular theory of causation sug-. 51. Fig. ... of these two layers as a result of episodic .... Anveden Hertzberg L, Gauderer MW, Elder JS.

  2. A Hermeneutical Journey throughout the Phenomenology of Edith Stein and Hedwig Conrad-Martius

    Directory of Open Access Journals (Sweden)

    Carmen Cozma

    2011-05-01

    Full Text Available Book review to: Angela Ales Bello, Francesco Alfieri, Mobeen Shahid (eds.. Edith Stein. Hedwig Conrad-Martius. Fenomenologia Metafisica Scienze. Bari: Edizioni Giuseppe Laterza di Giuseppe Laterza, 2010. Pp.500

  3. Trovato, Giuseppe (2016. Mediación lingüística y enseñanza de español/LE. Cuadernos de didáctica del español/LE. Madrid: Arco/Libros.

    Directory of Open Access Journals (Sweden)

    Nieves Mendizábal De La Cruz

    2017-07-01

    Full Text Available La mediación lingüística y cultural es un tema de relevancia desde que el Marco Común Europeo de Referencia la incluyó como una destreza más del aprendizaje de lenguas. En esta reseña resumimos la fundamentación teórica y metodología que utiliza Trovato en su libro. También destacamos las aportaciones que este autor sugiere para poner en práctica la competencia mediadora en las clases de E/LE.

  4. Tüdimus ; Levant ; Agoonia ; Varjutus ; Mälestuseks ; Jõed ; Jõulud ; Kui sina mu vend ; Faas ; Maetud sadam ; Õhtul ; Needus ; Juuni ; Magada ; Rahu : [luuletused] / Giuseppe Ungaretti ; tõlk. Malle Talvet ja Auli Ott

    Index Scriptorium Estoniae

    Ungaretti, Giuseppe

    2003-01-01

    Andmed autori kohta lk. 28. Orig.: Noia ; Levante ; Agonia ; Chiaroscuro ; In memoria ; I fiumi ; Natale ; Se tu mio fratello ; Fase ; Il porto sepolto ; Stasera ; Dannazione ; Giugno ; Dormire ; Quiete

  5. Tüdimus ; Levant ; Agoonia ; Varjutus ; Mälestuseks ; Jõed ; Jõulud ; Kui sina mu vend ; Faas ; Maetud sadam ; Õhtul ; Needus ; Juuni ; Magada ; Rahu : [luuletused] / Giuseppe Ungaretti ; tõlk. Malle Talvet ja Auli Ott

    Index Scriptorium Estoniae

    Ungaretti, Giuseppe

    2003-01-01

    Andmed autori kohta lk. 28. Orig.: Noia ; Levante ; Agonia ; Chiaroscuro ; In memoria ; I fiumi ; Natale ; Se tu mio fratello ; Fase ; Il porto sepolto ; Stasera ; Dannazione ; Giugno ; Dormire ; Quiete

  6. CRRES/SPACERAD (Combined Release and Radiation Effects Satellite/Space Radiation Effects Program) Experiment Descriptions.

    Science.gov (United States)

    1985-01-24

    A., Hertzberg, E., Battel, S.J., Altwegg-Von Burg, K., and Balsiger, H. (1984) AMPTE/CCE hot plasma composition experiment (HPCE), submitted to IEEE...CCE hot plasma composition experiment (HPCE), submitted to IEEE Trans. Remote Sensing. 151 iL Contents 1. Scientific Objectives 153 2. Applications 154

  7. Pædagogisk teori & arkitektonisk form

    DEFF Research Database (Denmark)

    Berg Nielsen, Kristian

    2000-01-01

    "Om Hertzbergers skoler kan det sammenfattende siges, at de både er i overensstemmelse med dette overordnede formål og med de intentioner, som ligger i Montessori-tænkningen. I forhold til dette pædagogiske program er arkitektens rolle den samme som ved andre typer af byggerier: making space...

  8. DARPA Quantum Network Testbed

    Science.gov (United States)

    2007-07-01

    Bovino , Giuseppe Castagnoli, Artur Ekert, Pawel Horodecki, Carolina Moura Alves, and Alexander V. Sergienko, “Direct Measurement of Nonlinear...Integrated Optical Source of Twin Photons,” Physical Review A, v. 71, 033812 (2005). 14. F. A. Bovino , P. Varisco, A. Martinoli, P. De Nicolo, S. Bruzzo...Antonio Bovino , Pietro Varisco, Anna Maria Colla, Giuseppe Castagnoli, Giovanni Di Giuseppe and Alexander V. Sergienko “Effective Fiber-Coupling of

  9. The multitudinous creativity of the contemporary capitalisms

    Directory of Open Access Journals (Sweden)

    Ionuț Bârliba

    2015-12-01

    Full Text Available Creative Capitalism, Multitudinous Creativity, Radicalities and Alterities, Edited by Giuseppe Cocco and Barbara Szaniecki, Lexington Books, Lanham. Boulder. New York. London, 2015, 269p.

  10. Dynamic Information Management and Exchange for Command and Control Applications: A Framework in Support of Emergency Management for Specified and Unspecified Emergencies

    Science.gov (United States)

    2014-03-01

    UNIVERSITA’ DEGLI STUDI DELL’INSUBRIA DIPARTIMENTO DI INFORMATICA E COMUNICAZIONE VIA GIUSEPPE MAZZINI 5, VARESE 21100 ITALY EOARD Grant 10-3080...UNIVERSITA’ DEGLI STUDI DELL’INSUBRIA DIPARTIMENTO DI INFORMATICA E COMUNICAZIONE VIA GIUSEPPE MAZZINI 5, VARESE 21100 ITALY 8. PERFORMING

  11. Improved heuristic algorithm for selection of tear streams and precedence ordering in process flowsheeting computations

    Directory of Open Access Journals (Sweden)

    Kristian M. Lien

    1990-01-01

    Full Text Available This paper presents a new algorithm based on the heuristic tearing algorithm by Gundersen and Hertzberg (1983. The basic idea in both the original and the proposed algorithm is sequential tearing of strong components which have been identified by an algorithm proposed by Targan (1972. The new algorithm has two alternative options for selection of tear streams, and alternative precedence orderings may be generated for the selected set of tear streams. The algorithm has been tested on several problems. It has identified minimal (optimal tear sets for all of them, including the four problems presented in Gundersen and Hertzberg (1983 where the original algorithm could not find a minimal tear set. A Lisp implementation of the algorithm is described, and example problems arc presented.

  12. Taking a Regional Healthcare Coalition Approach to Mitigating Surge Capacity Needs of Mass Casualty or Pandemic Events

    Science.gov (United States)

    2012-06-01

    gaining motivation for employees or, as exemplified in this case, coalition participants.59 The theory posits that there are two factors that... Motivation -Hygiene/Satisfiers Two-Factor Theory outline from the 1959 book; The Motivation to Work by Frederick Hertzberg; NetMBA web search 2/24/12; http...www.netmba.com/mgmt/ob/ motivation / herzberg / 43 of the work of the group, individual responsibility given to members, achievements of the

  13. Adolescents’ Self-concept Short Scale: A version of PHCSCS

    OpenAIRE

    Veiga, Feliciano; Leite, António

    2016-01-01

    Problem Statement: The adolescents’ self-concept has remained as a powerful issue in educational context. The lack of assessment instruments, especially in shorted version and with studied psychometric characteristics, has constituted a problem. Purpose of Study: This study presents the construction of “Adolescents’ Self-concept Short Scale” (ASCSS), using the Portuguese adaptation (Veiga & Domingues, 2012) of the Piers-Harris Children's Self-Concept Scale (Piers & Hertzberg, 2002). Res...

  14. Religious Zionism and Israeli Settlement Policy

    Science.gov (United States)

    2014-06-01

    Rodinson, Israel and the Arabs (New York: Penguin Books, 1982), 13. 4. Friedman, Zealots, xxviii. 5. Arthur Hertzberg, The Zionist Idea: A...would have allowed refugees from the 1948 War of Independence, or their children, to return to Israeli territory, thus greatly endangering Jewish...and which would have further endangered dreams of a united Greater Israel, were never fully realized.264 There are several other examples of

  15. An Empirical Analysis of Job Satisfaction Factors.

    Science.gov (United States)

    1987-09-01

    actualization. He argues that these needs motivate behavior in a pyramid sense. According to Maslow , higher need levels are not sought and may not be fully...most relevant are institutionlized theories such as Maslow and Hertzberg. Since the early 1900’s, management has been interested in the study of worker...those which correspond most closely to their position on the need hierarchy (Locke, 1976:1308). Critics of Maslow rally around his unsubstantiated theory

  16. Vtoraja zhizn klassiki estonskogo kinematografa / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2006-01-01

    Oskar Lutsu jutustuse järgi valminud mängufilm "Kevade" restaureeriti ja digitaliseeriti Soomes Digital Film Finland poolt, restauraator Giuseppe di Giorgio. Lisatud nimekiri "Taastamise ootel" filmidest, mis "Eesti film 100" raames restaureerimist ootavad

  17. Värskelt pestud "Kevade"

    Index Scriptorium Estoniae

    2006-01-01

    Oskar Lutsu jutustuse järgi valminud mängufilm "Kevade" (1969) restaureeriti ja digitaliseeriti Soomes Digital Film Finland poolt, restauraator Giuseppe di Giorgio. Filmi näeb 13. aprillil kinos "Sõprus"

  18. Arno, Teele ja Toots naasevad kinolinale / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2006-01-01

    Oskar Lutsu jutustuse järgi valminud mängufilm "Kevade" (1969) restaureeriti ja digitaliseeriti Soomes Digital Film Finland poolt, restauraator Giuseppe di Giorgio. Lisatud nimekiri "Taastamise ootel" filmidest, mis "Eesti film 100" raames restaureerimist ootavad

  19. Dairy Sheep Nutrition

    OpenAIRE

    Rosanna Scipioni

    2010-01-01

    This book, edited by the colleague Giuseppe Pulina, is the result of the project "Further development of a diet formulation model for sheep and goat", supported by the Ministry of Agricultural and Forestry Policies, in Italy.

  20. Opernõi kompozitor Kerubini v Kontsertnom zale : Opera Arcimboldo v galereje Sammas / Ilja Sindelevitsh

    Index Scriptorium Estoniae

    Sindelevitsh, Ilja

    2001-01-01

    Kunstinäitustest Tallinnas: "Nordic Glass" Kunstihoones ja Ruth Huimerinna ning Tiit Veermäe lavastatud fotode näitusest "Opera Arcimboldo" galeriis Sammas. Itaalia kunstnikust Giuseppe Archimboldost

  1. Opernõi kompozitor Kerubini v Kontsertnom zale : Opera Arcimboldo v galereje Sammas / Ilja Sindelevitsh

    Index Scriptorium Estoniae

    Sindelevitsh, Ilja

    2001-01-01

    Kunstinäitustest Tallinnas: "Nordic Glass" Kunstihoones ja Ruth Huimerinna ning Tiit Veermäe lavastatud fotode näitusest "Opera Arcimboldo" galeriis Sammas. Itaalia kunstnikust Giuseppe Archimboldost

  2. "Mees, naine ja köök" ootab järge / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2007-01-01

    Eneken Maripuu ja Hannes Starkopfi näitus "Mees, naine ja köök" Hobusepea galeriis kuni 6. VIII. Hannes Starkopf on lähtunud itaalia maneristliku maalikunstniku Giuseppe Archimboldo (1527-1593) teosest "Suvi"

  3. Arno, Teele ja Toots naasevad kinolinale / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2006-01-01

    Oskar Lutsu jutustuse järgi valminud mängufilm "Kevade" (1969) restaureeriti ja digitaliseeriti Soomes Digital Film Finland poolt, restauraator Giuseppe di Giorgio. Lisatud nimekiri "Taastamise ootel" filmidest, mis "Eesti film 100" raames restaureerimist ootavad

  4. Mona Lisa kuulsa naeratuse saladus leidis lahenduse / Johannes Saar

    Index Scriptorium Estoniae

    Saar, Johannes, 1965-

    2004-01-01

    Firenze kunstiajalooõpetaja Giuseppe Pallanti jõudis 25-aastase arhiivitöö tulemusena järeldusele, et Leonardo da Vinci Mona Lisa modelliks on siidikaupmehe Francesco del Giocondo abikaasa Lisa Gerardini

  5. Vtoraja zhizn klassiki estonskogo kinematografa / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2006-01-01

    Oskar Lutsu jutustuse järgi valminud mängufilm "Kevade" restaureeriti ja digitaliseeriti Soomes Digital Film Finland poolt, restauraator Giuseppe di Giorgio. Lisatud nimekiri "Taastamise ootel" filmidest, mis "Eesti film 100" raames restaureerimist ootavad

  6. Värskelt pestud "Kevade"

    Index Scriptorium Estoniae

    2006-01-01

    Oskar Lutsu jutustuse järgi valminud mängufilm "Kevade" (1969) restaureeriti ja digitaliseeriti Soomes Digital Film Finland poolt, restauraator Giuseppe di Giorgio. Filmi näeb 13. aprillil kinos "Sõprus"

  7. Carravaggio surmapõhjus teada / Maria-Kristiina Soomre

    Index Scriptorium Estoniae

    Soomre, Maria-Kristiina, 1978-

    2002-01-01

    Itaalia arhitekt Giuseppe La Fauci leidis sadamalinnas Porto Ercoles paberi, mida võib pidada Caravaggio mitteametlikuks surmatunnistuseks. Dokument tõendab, et Michelangelo Merisi da Caravaggio suri linna haiglas 18. juulil 1610

  8. Reply to "Methane origin in the Samail ophiolite: Comment on 'Modern water/rock reactions in Oman hyperalkaline peridotite aquifers and implications for microbial habitability'" [Geochim. Cosmochim. Acta 179 (2016) 217-241

    Science.gov (United States)

    Miller, Hannah M.; Matter, Jürg M.; Kelemen, Peter; Ellison, Eric T.; Conrad, Mark; Fierer, Noah; Ruchala, Tyler; Tominaga, Masako; Templeton, Alexis S.

    2017-01-01

    We thank Dr. Giuseppe Etiope for his comment and the opportunity to further discuss why we consider the origin of the methane detected in subsurface fluids obtained from a peridotite aquifer in Oman to be enigmatic.

  9. Suurlinnakorteri kellavärgiga apelsin / Adrian von Moos

    Index Scriptorium Estoniae

    Moos, Adrian von

    2008-01-01

    Ameerika sisekujundaja Giuseppe Pica New Yorgis asuvast korterist, kus omanik eksponeerib oma kunstikogu ja on sisustamisel püüdnud luua muljet avarusest. Kodune galerii on ka mugav elupaik. 8 värv. vaadet

  10. Tchaikovsky: Symphony No. 5 in E minor, Op. 64 / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1994-01-01

    Uuest heliplaadist "Tchaikovsky: Symphony No. 5 in E minor, Op. 64; Rimsky-Korsakov: Russian Easter Festival Overture, Op. 36. Philharmonia Orchestra / Giuseppe Sinopoli; Overture - selected comparison: Gothenburg SO, Järvi (3/91) DG 429984-2GH

  11. Tchaikovsky: Symphony No. 5 in E minor, Op. 64 / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1994-01-01

    Uuest heliplaadist "Tchaikovsky: Symphony No. 5 in E minor, Op. 64; Rimsky-Korsakov: Russian Easter Festival Overture, Op. 36. Philharmonia Orchestra / Giuseppe Sinopoli; Overture - selected comparison: Gothenburg SO, Järvi (3/91) DG 429984-2GH

  12. [Peano's challenge: mathematics and paranoia].

    Science.gov (United States)

    Bèttica-Giovannini, R

    1982-01-01

    With reference to the "clinical case" of Daniel Paul Schreber, possible relationships between mathematics and paranoia are discussed. The piedmontese mathematician Giuseppe Peano seems to be in agreement with the french philosopher and psychiatrist Jacques Lacan.

  13. Giovanni Bignami per Mostra Centenario Pontecorvo

    CERN Multimedia

    CERN Visual Media Office; Vincenzo Cavasinni

    2012-01-01

    Giovanni Bignami tells anecdote reported by Giuseppe occhialini on Bruno Pontecorvo's departure to the USSR. The clip will be used within the Pontecorvo exhibition organized by Pisa Univesrity on the occasion of Pontecorvo's 100th anniversary.

  14. Mona Lisa kuulsa naeratuse saladus leidis lahenduse / Johannes Saar

    Index Scriptorium Estoniae

    Saar, Johannes, 1965-

    2004-01-01

    Firenze kunstiajalooõpetaja Giuseppe Pallanti jõudis 25-aastase arhiivitöö tulemusena järeldusele, et Leonardo da Vinci Mona Lisa modelliks on siidikaupmehe Francesco del Giocondo abikaasa Lisa Gerardini

  15. Suurlinnakorteri kellavärgiga apelsin / Adrian von Moos

    Index Scriptorium Estoniae

    Moos, Adrian von

    2008-01-01

    Ameerika sisekujundaja Giuseppe Pica New Yorgis asuvast korterist, kus omanik eksponeerib oma kunstikogu ja on sisustamisel püüdnud luua muljet avarusest. Kodune galerii on ka mugav elupaik. 8 värv. vaadet

  16. Ricerca e diffusione del sapere: un’intervista a Chiara Frugoni / Research and spreading of knowledge: an interview with Chiara Frugoni

    Directory of Open Access Journals (Sweden)

    Giuseppe Capriotti

    2013-06-01

    Full Text Available Chiara Frugoni, una delle massime medieviste italiane, risponde alle domande di Giuseppe Capriotti sull’importanza della comunicazione ad un vasto pubblico dei risultati della ricerca scientifica.  Chiara Frugoni, one of the greatest Italian expert of medieval history, answers to Giuseppe Capriotti’s questions about the importance of communicating the results of the scientific research to a wider audience.

  17. Laser-Produced Plasmas and Radiation Sources.

    Science.gov (United States)

    1980-01-31

    Vlases, H. Rutkowski, A. Hertzberg, A. Hoffman, L. Steinhauer, J. Dawson, D.R. Cohn, W. Halverson, B. Lax, J.D. Daugherty, J.E. Eninger , E.R. Pugh, T.K...Meeting, Albuquerque (October 1974). J.D. Daugherty, J.E. Eninger , D.R. Cohn, and W. Halverson, "Scaling of Laser Heated Plasmas Confined in Long Solenoids...Cohn, H.E. Eninger , W. Halverson, and D.J. Rose, "Stress, Dissipation, and Neutronics Constraints on ’fagnets for Laser-Solenoid Reactors," APS Plasma

  18. Stuttering therapy in 1837 and a young boy's dramatic experience.

    Science.gov (United States)

    Preus, A

    1994-01-01

    This is a historical account of the first known case of stuttering therapy in Norway. In his autobiography, school administrator and politician Nils Hertzberg relates how he in 1837 as a 10-year-old boy travelled on horseback, skis and by boat across Norway from west to east and back in order to receive therapy from a travelling German speech teacher C.F. Bansmann. The article provides extracts from the exciting and dramatic journey, describes Bansmann's method and offers some comments on stuttering and stuttering therapy.

  19. Abitare i luoghi della formazione / Living places of education

    Directory of Open Access Journals (Sweden)

    Gioconda Cafiero

    2016-07-01

    Full Text Available L’architettura, attraverso il complesso fenomeno dell’abitare, contribuisce alla costruzione dell’uomo, così come l’uomo costruisce il suo mondo attraverso di essa. Dopo il fondativo ruolo dell’architettura della casa, quella dei luoghi deputati alla formazione ricopre il ruolo di interpretare e costruire la qualità dell’uomo quale essere sociale, precorrendo l’urbanità e ponendo le basi della capacità di abitare lo spazio condiviso. La lettura di realizzazioni di H. Hertzberger esemplifica l’integrazione tra visione pedagogica e progetto architettonico, visto proprio come strumento di formazione. / Architecture, through the complex phenomenon of living, contributes to the construction of man, as man builds its world through it. After the founding role of architecture of the house, one of the places dedicated to training has the role of interpreting and build the quality of man as a social being, anticipating urbanity and laying the foundations of the ability to live the shared space. Reading H. Hertzberger exemplifies the integration between the pedagogical vision and the architectural design, seen as a training tool.

  20. Golden Jubilee photos: The first experiments

    CERN Multimedia

    2004-01-01

    A year after the commissioning of the Synchrocyclotron (SC), the first experiments were already starting to bear fruit. In July 1958, Tito Fazzini, Giuseppe Fidecaro, Alec Merrison, Helmut Paul and Alvin Tollestrup produced conclusive evidence that approximately one pion in ten thousand decayed into an electron and a neutrino, as predicted by the weak interaction theory. This, the first of CERN's great discoveries, effectively put an end to the controversy that had been raging at the time. A few years later, Giuseppe Fidecaro began a collaboration at CERN with his wife Maria. In the image, Giuseppe and Maria Fidecaro in 1963, surrounded by spark chambers, inside the detector for the experiment on the decay of the rho meson into a pi meson and a photon.

  1. Handbook of graph drawing and visualization

    CERN Document Server

    Tamassia, Roberto

    2013-01-01

    Planarity Testing and Embedding Maurizio PatrignaniCrossings and Planarization Christoph Buchheim, Markus Chimani, Carsten Gutwenger, Michael Jünger, and Petra MutzelSymmetric Graph Drawing Peter Eades and Seok-Hee HongProximity Drawings Giuseppe LiottaTree Drawing Algorithms Adrian RusuPlanar Straight-Line Drawing Algorithms Luca VismaraPlanar Orthogonal and Polyline Drawing Algorithms Christian A. Duncan and Michael T. GoodrichSpine and Radial Drawings Emilio Di Giacomo, Walter Didimo, and Giuseppe LiottaCircular Drawing Algorithms Janet M. Six and Ioannis G. TollisRectangular Drawing Algori

  2. Complex and Unpredictable Cardano

    CERN Document Server

    Ekert, Artur

    2008-01-01

    This purely recreational paper is about one of the most colorful characters of the Italian Renaissance, Girolamo Cardano, and the discovery of two basic ingredients of quantum theory, probability and complex numbers. The paper is dedicated to Giuseppe Castagnoli on the occasion of his 65th birthday. Back in the early 1990s, Giuseppe instigated a series of meetings at Villa Gualino, in Torino, which brought together few scattered individuals interested in the physics of computation. By doing so he effectively created and consolidated a vibrant and friendly community of researchers devoted to quantum information science. Many thanks for that!

  3. Download the whole Issue (7Mb

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2010-06-01

    Full Text Available Peer reviewed by Maria Pia Alberzoni, Enrico Artifoni, Sofia Boesch Gajano, Renato Bordone, Cécile Caby, Luigi Canetti, Giovanni Ceccarelli, Germana Gandino, Jochen Johrendt, Giovanni Miccoli, Giuliano Milani, Luciano Palermo, Francesco Panarelli, Beatrice Pasciuta, Giuseppe Petralia, Domenico Pezzini, Giuliano Pinto, Antonio Rigon, Mauro Ronzani, Maria Clara Rossi, Francesco Salvestrini, Ludwig Schmugge, Giacomo Todeschini, Francesco G.B. Trolese, Massimo Vallerani.

  4. At the Omega Facility

    CERN Multimedia

    1977-01-01

    Behind the large gas Cerenkov counter (not visible) one gets ready for the WA4 experiment. On the left stands a large scintillator hodoscope. On the right, lead-glass counters are fitted into their support. Giuseppe Marinoni (centre) and Alois Sigrist (right).

  5. On the Measurement of Two-Photon Single-Mode Coupling Efficiency in Parametric Down-Conversion Photon Sources

    Science.gov (United States)

    2004-04-01

    could be used to differentiate between the two models. Acknowledgments This work was supported in part by DARPA/ QUIST , ARDA and ARO and partially by...Oberparleiter M and Weinfurter H 2001 Phys. Rev. A 6402 023802 [23] Bovino F A, Varisco P, Colla A M, Castagnoli G, Di Giuseppe G and Sergienko A V 2003

  6. Bagatellid : maailm / Mirjam Tally

    Index Scriptorium Estoniae

    Tally, Mirjam, 1976-

    2008-01-01

    Bachi ja Mozarti uued ilmed. Hilary Hahnilt ja Mayuko Kamiolt uued plaadid. Lahkus tenor Giuseppe di Stefano. Henri Dutilleux pälvis Kuningliku Filharmooniaühingu kuldmedali. Inglismaa vanim spinett müügil. Guarneri hinnaline viiul helises taas

  7. American Cultural Diplomacy and Post-War Educational Reforms: James Bryant Conant's Mission to Italy in 1960

    Science.gov (United States)

    Mariuzzo, Andrea

    2016-01-01

    This paper, largely based on new, previously unused documents from US archives, considers the consultancy group financed by the Ford Foundation in 1960 to support the school reforms the Italian Minister of Education Giuseppe Medici was promoting. The group was headed by James Bryant Conant, and its evaluations were based on principles of…

  8. Espectrometría de masas aplicada a la proteómica

    OpenAIRE

    Lattanzio, Giuseppe

    2012-01-01

    1 doc. .pdf, 36 Pags, copia de presentación original del autor. Giuseppe Lattanzio forma parte del Grupo de Fisiología de Estrés Abiótico en Plantas (Plant Stress Physiology), integrado en la EEAD-CSIC

  9. On Thursday 2 December, the Director-General received the 14 staff members who began to work in 1979 and celebrated 25 years of service at CERN.

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Beugnet Claude / AB Bourgeois Georges / AB Goossens Michel / IT Herzog Patrick / IT Jeanneret Jean-Bernard / AB Lacarrère Daniel / TS Mollay Robert / TS Mornacchi Giuseppe / PH Ployer Annie / DSU Remondino Vittorio / AT Stellfeld Donat / AB Taureg Hans / PH Terrier Jean-Pierre / AB Wehrle Urs / AB

  10. Postimees hääletas võitjaks Korea filmi "Tühi maja"

    Index Scriptorium Estoniae

    2004-01-01

    Tallinna VIII Pimedate Ööde Filmifestivali võistlusfilme hindas 5-palli süsteemis viis asjatundjat : Sulev Teinemaa, Kristiina Davidjants, Olev Remsu, Jaak Allik Ja Giuseppe Gariazzo. Kõik esitavad oma hinnangu lühikokkuvõtte. Lisatud lõplik tabel

  11. Postimehe žürii hindab võistlusprogrammi filme

    Index Scriptorium Estoniae

    2004-01-01

    Tallinna VIII Pimedate Ööde Filmifestivali võistlusfilme hindab 5-palli süsteemis viis asjatundjat. Seekord põhjendavad oma hinnangut Giuseppe Gariazzo (Tšehhi lavastaja Jan Hrebejki film "Üles-alla") ja Kristiina Davidjants (Taani-Rootsi "Päev ja öö" - režii Simon Staho)

  12. Observed variations in stratification and currents in the Zuari estuary, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Sundar, D.; Unnikrishnan, A.S.; Michael, G.S.; Kankonkar, A.; Nidheesh, A.G.; Subeesh, M.P.

    Manca, Giuseppe Capelli, Francesco La Vigna, Roberto Mazza, Annalisa Pascarella 2014. Wind-induced salt-wedge intrusion in the Tiber river mouth (Rome–Central Italy). Environ. Earth Sci. (2014) 72:1083–1095, DOI 10.1007/s12665-013-3024-5 3. Gustavo...

  13. Is "Economia Aziendale" Research Programme "Fit for Purpose"? A Commentary on "Contextualizing the Intermediate Financial Accounting Courses in the Global Financial Crisis"

    Science.gov (United States)

    Galassi, Giuseppe

    2011-01-01

    In his commentary, from the perspective of a professor who has spent a lifetime in a highly vocational scientific field like accounting and business economics, Giuseppe Galassi puts forth an alternate proposal to the one suggested in Bloom and Webinger's (2011) article. Bloom and Webinger suggest that disciplines, including management, economics,…

  14. Azione/Reazione: il futurismo in Belgio e in Europa

    Directory of Open Access Journals (Sweden)

    Günter Berghaus

    2013-12-01

    Full Text Available Recensione di: Bart van den Bossche, Giuseppe Manica & Carmen Van den Bergh (a cura di, Azione/ Reazione: Il futurismo in Belgio e in Europa. Atti del Convegno Internazionale Bruxelles/Lovanio, 19-20 novembre 2009, Firenze, Franco Cesati Editore, 2012, 336 p., ISBN:9788876674372, € 30,00.

  15. Low-Cost and High-Impact Environmental Solutions for Military Composite Structures

    Science.gov (United States)

    2005-12-15

    Dr. Tania Dey Ms. Amuta Jeyarajasingam Ms. Ji-Hean Lee Dr. Giuseppe R. Palmese (POC) Mr. Justin Robertson Mr. E. Jason Robinette Preparation...concentration on particulate matter Secondary Visibly cleaner engine Cleaner turbine blades and exhaust Secondary Table 70. Actual versus Expected...determine uncertainty for each condition Additive showed no effect on PAH content of particulates. Visibly cleaner engine Cleaner hot

  16. Tuna & täna / Mati Soomre

    Index Scriptorium Estoniae

    Soomre, Mati, 1944-2015

    2006-01-01

    9. märtsil 1842 Milano La Scala teatris esietendunud Giuseppe Verdi ooperi "Nabucco" III vaatuses kõlanud "Orjade koor" sõnad põhinevad Piibli Lauluraamatu 137. laulul, mida on viisistanud paljud heliloojad. 12. märtsil 1946 sündis USA näitleja ja laulja Liza Minelli

  17. Postimehe žürii hindab võistlusprogrammi filme

    Index Scriptorium Estoniae

    2004-01-01

    Tallinna VIII Pimedate Ööde Filmifestivali võistlusfilme hindab 5-palli süsteemis viis asjatundjat. Seekord põhjendavad oma hinnangut Giuseppe Gariazzo (Tšehhi lavastaja Jan Hrebejki film "Üles-alla") ja Kristiina Davidjants (Taani-Rootsi "Päev ja öö" - režii Simon Staho)

  18. Postimees hääletas võitjaks Korea filmi "Tühi maja"

    Index Scriptorium Estoniae

    2004-01-01

    Tallinna VIII Pimedate Ööde Filmifestivali võistlusfilme hindas 5-palli süsteemis viis asjatundjat : Sulev Teinemaa, Kristiina Davidjants, Olev Remsu, Jaak Allik Ja Giuseppe Gariazzo. Kõik esitavad oma hinnangu lühikokkuvõtte. Lisatud lõplik tabel

  19. Artists Paint ... Fantasy

    Science.gov (United States)

    Herberholz, Barbara

    2012-01-01

    When he painted a portrait of Holy Roman Emperor Rudolph II (1552-1612), Giuseppe Arcimboldo used his imagination, and portrayed him as "Vertumnus," the Roman god of vegetation and the seasons. It's fun to find the different fruits, vegetables and flowers he used: pea-pod eyelids, a gourd for the forehead. Court painters of the time usually…

  20. Due taccuini romani di disegni: un’idea della smart-city di fine Seicento

    Directory of Open Access Journals (Sweden)

    Francesca Salvemini

    2015-05-01

    Full Text Available It has been discussed in the last decades the split personality of Giuseppe Passeriin two homonyms contemporaries, one architect and the other painter. The endof the seventeenth century saw the triumph of figures of artists such the samePasseri and Alessandro Specchi, which at ease move dynamically in the designcommonly understood among the arts.

  1. Tuna & täna / Mati Soomre

    Index Scriptorium Estoniae

    Soomre, Mati, 1944-2015

    2006-01-01

    9. märtsil 1842 Milano La Scala teatris esietendunud Giuseppe Verdi ooperi "Nabucco" III vaatuses kõlanud "Orjade koor" sõnad põhinevad Piibli Lauluraamatu 137. laulul, mida on viisistanud paljud heliloojad. 12. märtsil 1946 sündis USA näitleja ja laulja Liza Minelli

  2. Is "Economia Aziendale" Research Programme "Fit for Purpose"? A Commentary on "Contextualizing the Intermediate Financial Accounting Courses in the Global Financial Crisis"

    Science.gov (United States)

    Galassi, Giuseppe

    2011-01-01

    In his commentary, from the perspective of a professor who has spent a lifetime in a highly vocational scientific field like accounting and business economics, Giuseppe Galassi puts forth an alternate proposal to the one suggested in Bloom and Webinger's (2011) article. Bloom and Webinger suggest that disciplines, including management, economics,…

  3. Test Review: Anger Regulation and Expression Scale

    Science.gov (United States)

    Cavlazoglu, Baki; Erdogan, Niyazi; Paine, Taylor; Jones, Meredith

    2013-01-01

    This review focuses on the Anger Regulation and Expression Scale (ARES) which was developed by DiGiuseppe and Tafrate (2011) and published by Multi-Health Systems Inc. The ARES was designed to be a self-report measure of anger expression and regulation in youth aged 10 to 17 years and was intended to be used in screening, individual assessment,…

  4. Maailm meie jalge all / Philippe Dayan

    Index Scriptorium Estoniae

    Dayan, Philippe

    2007-01-01

    Jalatsidisainerite Stuart Weitzman'i (USA), Jimmy Choo (Inglismaa), Manolo Blahnik'i (USA), Georgina Goodman'i (Inglismaa), Franziska Hübener'i (Brasiilia), Edmundo Castillo (Itaalia), Christian Louboutin'i (Prantsusmaa), Giuseppe Zanotti (Itaalai), Bruno Frisoni (Prantsusmaa), Pierre Hardy (Prantsusmaa) eluloolisi andmeid ja loomingu lühitutvustus

  5. Ooperiaasta võimas algus / Tarmo Virki

    Index Scriptorium Estoniae

    Virki, Tarmo

    2003-01-01

    Einojuhani Rautavaara uue ooperi "Rasputin" esietendusest Soome Rahvusooperis 19. sept. (dirigent Mikko Franck) ja etendustest 22., 24., 27. ja 30. sept. ning 3., 6., 9. ja 11. oktoobril. Giuseppe Verdi "Trubaduur" 11., 17. ja 20. sept ning 1. okt., dirigent Eri Klas. Leosh Janaceki "Katja Kabanova" esietendusest 12. detsembril

  6. American Cultural Diplomacy and Post-War Educational Reforms: James Bryant Conant's Mission to Italy in 1960

    Science.gov (United States)

    Mariuzzo, Andrea

    2016-01-01

    This paper, largely based on new, previously unused documents from US archives, considers the consultancy group financed by the Ford Foundation in 1960 to support the school reforms the Italian Minister of Education Giuseppe Medici was promoting. The group was headed by James Bryant Conant, and its evaluations were based on principles of…

  7. Press release. "Stem Cell Implants to Treat Spinal Cord Injury: No Scientific Evidence, Beware of Hope Thieves".

    Science.gov (United States)

    Carannante, Giuseppe

    2010-04-01

    A new alarm launched by Prof. Giuseppe Carannante, distinguished Turin surgeon and spokesman for SOMIPAR, the Italian medical association for paraplegia, during the association's XIV national congress underway in Palermo, Sicily since Thursday 18(th) March until Saturday 20(th) March.

  8. 76 FR 15209 - 150th Anniversary of the Unification of Italy, 2011

    Science.gov (United States)

    2011-03-21

    ... the Unification of Italy, 2011 By the President of the United States of America A Proclamation On March 17, Italy celebrates the 150th anniversary of its unification as a single state. On this day, we... own Union, Giuseppe Garibaldi's campaign for the unification of Italy inspired many around the...

  9. Due taccuini romani di disegni: un’idea della smart-city di fine Seicento

    OpenAIRE

    Francesca Salvemini

    2015-01-01

    It has been discussed in the last decades the split personality of Giuseppe Passeriin two homonyms contemporaries, one architect and the other painter. The endof the seventeenth century saw the triumph of figures of artists such the samePasseri and Alessandro Specchi, which at ease move dynamically in the designcommonly understood among the arts.

  10. Uudised

    Index Scriptorium Estoniae

    2006-01-01

    Giuseppe Verdi ooperi "Maskiball" uuslavastusest Malmös. Kantrilaulja Willie Nelsoni heliplaadist "Cowboys are Frequently Secretly". Helilooja Gustav Mahleri lapselaps Marina Mahler nõuab Austria Galeriilt tagasi Edvard Munchi maali "Suveöö rannas". Jamaical Kingstonis asuvast reggae-laulja Bob Marley sünnimajast, kus asuvad helistuudio ja muuseum

  11. Rita Levi-Montalcini: Presence in The Absence

    OpenAIRE

    2013-01-01

    Phone: +90 39 06 5017 03240 Fax: +39 06 5017 03313 e-mail: *The Balkan Medical Journal thanks Giuseppe Nicoloro for his permission to use the photograph he took (http://images.cdn.fotopedia.com/flickr-2967513551-original.jpg) (licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 2.0 Generic License)

  12. Maailm meie jalge all / Philippe Dayan

    Index Scriptorium Estoniae

    Dayan, Philippe

    2007-01-01

    Jalatsidisainerite Stuart Weitzman'i (USA), Jimmy Choo (Inglismaa), Manolo Blahnik'i (USA), Georgina Goodman'i (Inglismaa), Franziska Hübener'i (Brasiilia), Edmundo Castillo (Itaalia), Christian Louboutin'i (Prantsusmaa), Giuseppe Zanotti (Itaalai), Bruno Frisoni (Prantsusmaa), Pierre Hardy (Prantsusmaa) eluloolisi andmeid ja loomingu lühitutvustus

  13. Uudised

    Index Scriptorium Estoniae

    2006-01-01

    Giuseppe Verdi ooperi "Maskiball" uuslavastusest Malmös. Kantrilaulja Willie Nelsoni heliplaadist "Cowboys are Frequently Secretly". Helilooja Gustav Mahleri lapselaps Marina Mahler nõuab Austria Galeriilt tagasi Edvard Munchi maali "Suveöö rannas". Jamaical Kingstonis asuvast reggae-laulja Bob Marley sünnimajast, kus asuvad helistuudio ja muuseum

  14. Rahvusooperi Estonia 99. hooaeg algab nädala pärast / Christel Karits

    Index Scriptorium Estoniae

    Karits, Christel, 1966-

    2004-01-01

    Muusikaturu korraldamisest 18. sept. Estonia teatrihoone taga ajaloolisel turuplatsil. Katri Kaasik-Aaslavi ja Vaino Vahingu näidendi "Teatriromanss" (muusika arranzheerija ja pianist Olav Ehala) esietendusest Estonia kammersaalis 22. oktoobril. Giuseppe Verdi ooperi "Aida" etendamisest Rocca al Mare Onistar Tennisekeskuses 8.-10., 12.-17. oktoobril

  15. Two-factor theory – at the intersection of health care management and patient satisfaction

    Science.gov (United States)

    Bohm, Josef

    2012-01-01

    Using data obtained from the 2004 Joint Canadian/United States Survey of Health, an analytic model using principles derived from Herzberg’s motivational hygiene theory was developed for evaluating patient satisfaction with health care. The analysis sought to determine whether survey variables associated with consumer satisfaction act as Hertzberg factors and contribute to survey participants’ self-reported levels of health care satisfaction. To validate the technique, data from the survey were analyzed using logistic regression methods and then compared with results obtained from the two-factor model. The findings indicate a high degree of correlation between the two methods. The two-factor analytical methodology offers advantages due to its ability to identify whether a factor assumes a motivational or hygienic role and assesses the influence of a factor within select populations. Its ease of use makes this methodology well suited for assessment of multidimensional variables. PMID:23055755

  16. Two-factor theory - at the intersection of health care management and patient satisfaction.

    Science.gov (United States)

    Bohm, Josef

    2012-01-01

    Using data obtained from the 2004 Joint Canadian/United States Survey of Health, an analytic model using principles derived from Herzberg's motivational hygiene theory was developed for evaluating patient satisfaction with health care. The analysis sought to determine whether survey variables associated with consumer satisfaction act as Hertzberg factors and contribute to survey participants' self-reported levels of health care satisfaction. To validate the technique, data from the survey were analyzed using logistic regression methods and then compared with results obtained from the two-factor model. The findings indicate a high degree of correlation between the two methods. The two-factor analytical methodology offers advantages due to its ability to identify whether a factor assumes a motivational or hygienic role and assesses the influence of a factor within select populations. Its ease of use makes this methodology well suited for assessment of multidimensional variables.

  17. Radiative cooling of a solidifying droplet layer including absorption and scattering

    Science.gov (United States)

    Siegel, Robert

    1987-01-01

    A simple solution for the transient cooling of a solidifying layer filled with drops that can emit and scatter radiation is discussed, with application to a liquid drop radiator proposed for the Space Station (Mattick and Hertzberg, 1981). The layer remains at uniform temperature during solidification, and the outer portions rapidly lose heat, producing a variation along the length of the layer in the distribution of liquid concentration across the layer. The analysis is used to obtain both the amount of energy dissipated by the two-phase system at uniform temperature and the velocity distribution necessary to maintain a uniform liquid fraction across the entire layer at all locations along the layer length.

  18. A novel dataset on horizontal property rights in 126 jurisdictions.

    Science.gov (United States)

    Dari-Mattiacci, Giuseppe; Guerriero, Carmine

    2017-04-01

    The law and the economy are deeply influenced by horizontal property rights, which are the rules regulating legal direct and indirect takings between private parties. To foster research on the determinants and impact of these institutions, we illustrate here a novel data set partially employed in (Dari-Mattiacci, Giuseppe, Carmine Guerriero, 2015; Dari-Mattiacci, Giuseppe, Carmine Guerriero, Zhenxing Huang, 2016) [3], [4], and (Guerriero Carmine, 2016) [6] and describing the acquisition of ownership through adverse possession of personal and real property and the use of government takings to transfer real property from a private party to another private party in 126 jurisdictions. These data are based on the laws and judicial decisions prevailing in each jurisdiction between 1981 and 2011.

  19. Passions au miroir: Hugo et Garibaldi dans la solitude de l’Histoire

    Directory of Open Access Journals (Sweden)

    Marco Nuti

    2009-12-01

    Full Text Available In Mythic Imagery, a warrior is a hybrid man – a divine human being or a divinized mortal – who stands out of his own kind for his extraordinary skill to generate power. Being an undefined figure of man, equidistant from deity and humanity, the warrior hero represents the Human Community. Using his knowledge of what Giuseppe Garibaldi had done to unify Italy, Victor Hugo had the chance to annex to his political and literary fighting a contemporary hero who shared his own ideology. An amazing relationship put their destinies together, and the epistolary exchange Garibaldi (1863 strengthened this union. Giuseppe Garibaldi in Mentana (1867 is invested with the heroic legitimacy of a symbolical progressive movement. The experimental brotherhood between the poet and the warrior symbolized for Hugo a continuous questioning of the real power of poetical language.

  20. Per una lettura di “Finale di partita” di Samuel Beckett. Appunti da un seminario

    Directory of Open Access Journals (Sweden)

    Diana, Rosario

    2011-12-01

    Full Text Available [Reading Samuel Beckett's "Fin de Partie". Notes from a seminar]. The paper sets out the results of a didactic workshop about Fin de Partie (1957 by Samuel Beckett held by the Author at the ISPF. After clarifying the link between the concept of absurdity and the concept of contradiction, and touching the issue in Giuseppe Rensi, Jean-Paul Sartre and Albert Camus, the Author presents his ontological reading of Beckett’s play.

  1. Civil Society as a Game Changer: A Comparative Study of Political Transitions in Eastern Europe and the Middle East

    Science.gov (United States)

    2013-12-01

    unfold. He rejects the political crafting theory of Giuseppe Di Palma , which asserts that initiatives for transition by authoritarian forces might...forces, such as human rights groups and the environmental movement, by putting human rights and ecological issues on their agenda.167 WiP’s legitimacy...activities at the regional and national level. The Socio- ecological Union, for example, waged a nation-wide campaign against the construction of the

  2. 25 years of service

    CERN Multimedia

    2004-01-01

    On Thursday 2 December, the Director-General received the 14 staff members who began to work in 1979, CERN's 25th anniversary, and are now themselves celebrating 25 years of service at CERN. Beugnet Claude / AB Bourgeois Georges / AB Goossens Michel / IT Herzog Patrick / IT Jeanneret Jean-Bernard / AB Lacarrère Daniel / TS Mollay Robert / TS Mornacchi Giuseppe / PH Ployer Annie / DSU Remondino Vittorio / AT Stellfeld Donat / AB Taureg Hans / PH Terrier Jean-Pierre / AB Wehrle Urs / AB

  3. International Conference on Coordination Chemistry (23rd) Held at Boulder, Colorado on 29 July - 3 August 1984. Abstracts of Paper.

    Science.gov (United States)

    1984-08-03

    ALKYNEHEXACARBONYLDICOBALT COMPOUNDS WITH ALKENES. Paola Michelin Lausarot, Lorenza Operti, Gian Angelo Vaglio, Mario Valle e Paolo Volpe Istituto di Chimica Generale ed...Stoin Vania N. No- guetra’, Assi V. Benedetti and Eliss 9. Saitovich. ainstituto do Qutica-UNCAJW, Compinss - SP - Brasil. blustitutdo Qusltica-MSP...ai L b,.. ,vb.? p~ too), W&36-1 SYNTHESES AND STRUCTURAL STUDIES OP SOMIE 1,4- BENZOD1AZEPINE COMPLEXES Adriano Benedetti Ca ~rlors and Giuseppe Toot

  4. “多蕾塔做丫什么美梦”——歌剧《燕子》选曲

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    三幕歌剧《燕子》(La rundine)由阿达米(Giusepp Adami)编剧,著名作曲家贾科莫·普契尼(Giacomo Puccini)谱曲,作于1914-1916年,1917年3月27日上演于蒙特卡洛(Monte Carlo)。

  5. Scrivere e leggere. Etnografia politica di un corso per l’alfabetizzazione di adulti sinti

    OpenAIRE

    2013-01-01

    Fin dai primi anni Sessanta diverse famiglie sinte imparentate fra loro cominciarono a svernare nelle città di Modena, Bologna e Reggio Emilia, continuando invece a spostarsi, da marzo a fine ottobre, lungo itinerari interprovinciali che toccavano fiere e sagre in Emilia Romagna, basso Veneto e bassa Lombardia (si partiva il 19 marzo, per la fiera di san Giuseppe, e si ritornava per la celebrazione dei morti).

  6. Autorialità e autorità del libretto di ballo del secondo Settecento: problematiche e prospettive di studio

    Directory of Open Access Journals (Sweden)

    Stefania Onesti

    2014-02-01

    Full Text Available This essay focus his attention on Italian ballet librettos of the second half of Eighteenth-century. The author gathers Italians librettos of Giuseppe Canziani, Antonio Muzzarelli, Onorato Viganò e Francesco Clerico from 1769 to 1810 in order to outline the main features of this source and, at the same time, to deal with some of the methodological problems related to his use.

  7. Retargeting the management of hypercholesterolemia – focus on evolocumab

    OpenAIRE

    Cicero, Arrigo; Colletti,Alessandro; Derosa, Giuseppe

    2016-01-01

    Alessandro Colletti,1 Giuseppe Derosa,2 Arrigo FG Cicero1 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, 2Department of Internal Medicine and Therapeutics, University of Pavia and Policlinico San Matteo Foundation, Pavia, Italy Abstract: Hypercholesterolemia is one of the main risk factors for atherosclerosis and cardiovascular diseases. The treatment is based on the modification of the diet and lifestyle and if necessary on a pharmacological therapy. The most...

  8. Retargeting the management of hypercholesterolemia – focus on evolocumab

    OpenAIRE

    Colletti A; Derosa G; Cicero AFG

    2016-01-01

    Alessandro Colletti,1 Giuseppe Derosa,2 Arrigo FG Cicero1 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, 2Department of Internal Medicine and Therapeutics, University of Pavia and Policlinico San Matteo Foundation, Pavia, Italy Abstract: Hypercholesterolemia is one of the main risk factors for atherosclerosis and cardiovascular diseases. The treatment is based on the modification of the diet and lifestyle and if necessary on a pharmacological therapy. The most...

  9. [The Montalenti archive].

    Science.gov (United States)

    Valente, Nicoletta

    2006-01-01

    The archival fund by Giuseppe Montalenti, the distinguished Italian genetist and biologist, comprehends correspondence--both personal and scientific--, papers on his activity as a collaborator to the Enciclopedia Treccani, documentation on Montalenti's engagement in the politics of science in Italy and abroad in the 1950s-60s, a collection of offprints and books. A large part of the archive refers to the activities of the IUSB (International Union of Biological Sciences).

  10. DMT:“Your present is our future”她从米兰来

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    DMT的电视发射机部高级技师Giuseppe Sandri有着意大利人典型的热情性格。他说不久前在城市电视台协会的南京会议上,对本刊和高级编辑梅杰印象都挺深,只是未及多谈,很高兴来到NAB又与我们相见。

  11. Potential drug–drug interactions in Alzheimer patients with behavioral symptoms

    OpenAIRE

    2015-01-01

    Giuseppe Pasqualetti, Sara Tognini, Valeria Calsolaro, Antonio Polini, Fabio Monzani Geriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Abstract: The use of multi drug regimens among the elderly population has increased tremendously over the last decade although the benefits of medications are always accompanied by potential harm, even when prescribed at recommended doses. The elderly populations are particularly at an increased risk of adverse ...

  12. An experimental study on adhesive or antiadhesiveand strong bio-inspired nanomaterials

    OpenAIRE

    Lepore, Emiliano

    2012-01-01

    This experimental PhD thesis presents the results of research performed in five different facilities: in the Laboratory of Bio-inspired Nanomechanics "Giuseppe Maria Pugno" at the Politecnico of Torino, the "Nanofacility Piemonte" at the INRIM Institute in Torino, the Division of Dental Sciences and Biomaterials of the Department of Biomedicine at the University of Trieste, the Physics Department of the Politecnico of Torino, the Toscano- Buono Veterinary Surgery in Torino and the Department ...

  13. Clinical utility of ivabradine in cardiovascular disease management: current status

    OpenAIRE

    Rosano GMC; Vitale C; Spoletini I; Volterrani M.

    2014-01-01

    Giuseppe MC Rosano,1,2 Cristiana Vitale,1,2 Ilaria Spoletini,1 Maurizio Volterrani11Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy; 2Cardiovascular and Cell Sciences Research Institute, St George's University of London, London, UK Abstract: Ivabradine is a selective antagonist of the funny channels with anti-anginal and anti-ischemic properties, approved for the treatment of coronary artery disease (CAD) and heart failure (HF). It provides pure heart rate redu...

  14. JC virus antibody index in natalizumab-treated patients: correlations with John Cunningham virus DNA and C-reactive protein level

    OpenAIRE

    Lanzillo R; Liuzzi R; Vallefuoco L; Moccia M; Amato L; Vacca G; Vacchiano V; Portella G.; Brescia Morra V

    2014-01-01

    Roberta Lanzillo,1 Raffaele Liuzzi,2 Luca Vallefuoco,3 Marcello Moccia,1 Luca Amato,1 Giovanni Vacca,1 Veria Vacchiano,1 Giuseppe Portella,3 Vincenzo Brescia Morra1 1Neurological Sciences Department, Federico II University, 2Institute of Biostructure and Bioimaging, National Research Council, 3Clinical Pathology Department, Federico II University, Naples, ItalyAbstract: Natalizumab-treated patients have a higher risk of developing progressive multifocal leukoencephalopathy. Exposure to John C...

  15. Depressive symptoms in Parkinson’s disease and in non-neurological medical illnesses

    OpenAIRE

    Assogna F; Fagioli S; Cravello L; Meco G; Pierantozzi M; Stefani A.; Imperiale F; Caltagirone C; Pontieri FE; Spalletta G

    2013-01-01

    Francesca Assogna,1 Sabrina Fagioli,1 Luca Cravello,1 Giuseppe Meco,2 Mariangela Pierantozzi,3 Alessandro Stefani,3 Francesca Imperiale,2 Carlo Caltagirone,1,3 Francesco E Pontieri,4 Gianfranco Spalletta11I.R.C.C.S. Santa Lucia Foundation, Rome, Italy; 2Department of Neurology and Psychiatry (Parkinson’s Centre) and Research Centre of Social Diseases (CIMS), University “Sapienza”, Rome, Italy; 3Department of Neuroscience, University “Tor Vergata&rdq...

  16. Effects of low-carbohydrate diet therapy in overweight subject with autoimmune thyroiditis: possible synergism with ChREBP

    OpenAIRE

    Esposito T; Lobaccaro JM; Esposito MG; Monda V; Messina A; Paolisso G; Varriale B; Monda M; Messina G

    2016-01-01

    Teresa Esposito,1,2 Jean Marc Lobaccaro,3 Maria Grazia Esposito,4 Vincenzo Monda,1 Antonietta Messina,1 Giuseppe Paolisso,5 Bruno Varriale,2 Marcellino Monda,1 Giovanni Messina1,6 1Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, 2Laboratory of Molecular Biology and Genetics, Department of Experimental Medicine, Second University of Naples, Naples, Italy; 3UMR, Clermont Université, Centre de Recherche en Nutrition Humaine ...

  17. The influence of parenting on maladaptive cognitive schema: a cross-sectional research on a group of adults

    OpenAIRE

    Pellerone M; Iacolino C; Mannino G; Formica I; Zabbara SM

    2017-01-01

    Monica Pellerone,1 Calogero Iacolino,1 Giuseppe Mannino,2 Ivan Formica,3 Simona Maria Zabbara1 1Faculty of Human and Social Sciences, “Kore” University of Enna, Enna, Sicily, Italy; 2Department of Jurisprudence, “LUMSA” University, Rome, Italy; 3Department of Cognitive, Psychological, Pedagogical Sciences and Cultural Studies, University of Study of Messina, Messina, Sicily, Italy Background: The literature emphasizes the role of early interpersonal exp...

  18. Proceedings of the Ship Control Systems Symposium (9th) Held in Bethesda, Maryland on 10-14 September 1990. Theme: Automation in Surface Ship Control Systems, Today’s Applications and Future Trends. Volume 5

    Science.gov (United States)

    1990-09-14

    Naval Sea Systems Command. He is the Chairman of the Marine Transportation Committee of IEEE and Chairman of the Electrical Panel and Machinery Committee...DrNautSc Dr. Carmine Giuseppe Biancardi is Senior Research Specialist at the Istituto Universitario Navale, Naples Italy and Visiting Professor at the... Universitario Navale, Naples, Italy. He has been Visiting Researcher at the National Maritime Research Center, Kings Point, NY and Visiting Lecturer

  19. The XX century architectural heritage in the Marche region. The Masters’ drawings and designs.

    Directory of Open Access Journals (Sweden)

    Ramona Quattrini

    2010-12-01

    Full Text Available In the history of architecture, Marche is often considered as a region that did not take part in the big developments of national architecture. Hence it’s meaningful to examine the architectonic events of the Region in the XX century and how much the Marche region has been the object of work by the great masters of the past century. A list of architects - called ‘masters’ – has been selected: Franco Albini, Gae Aulenti, Carlo Aymonino, Ernesto Basile, BBPRGuido Canella, Giancarlo De Carlo, Luigi Figini, Massimiliano Fuksas, Roberto Gabetti, Ignazio Gardella, Giorgio Grassi, Vittorio Gregotti, Adalberto Libera, Giovanni Michelucci, Gaetano Minnucci, Carlo Mollino, Luigi Moretti, Pier Luigi Nervi, Giuseppe Pagano, Edoardo Persico, Marcello Piacentini, Renzo Piano, Gio Ponti, Paolo Portoghesi, Franco Purini, Ludovico Quaroni, Mario Ridolfi, Aldo Rossi, Giuseppe Samonà, Antonio Sant’Elia; Alberto Sartoris, Carlo Scarpa, Giuseppe Terragni, Gino Valle, Vittoriano Viganò, Marco Zanuso, The research is a meaningful census of the works of the 20th century, whether they have been realized or not (projects, competitions, studies etc. and assigned to the masters listed above.

  20. Motivations, concerns, and expectations of Scandinavian health professionals volunteering for humanitarian assignments.

    Science.gov (United States)

    Bjerneld, Magdalena; Lindmark, Gunilla; McSpadden, Lucia Ann; Garrett, Martha J

    2006-01-01

    International nongovernmental organizations (NGOs) involved in humanitarian assistance employ millions of volunteers. One of the major challenges for the organizations is the high turnover rate among their personnel. Another is recruiting the right persons. As part of a series of studies investigating factors that affect the recruitment process and the success of assignment, this qualitative study examined health professionals' motivations for volunteering, their various concerns, and their expectations about themselves and the organizations for which they would work. The findings from focus group interviews with potential humanitarian volunteers were considered within the framework of Hertzberg's theory of motivations and Maslow's hierarchy of needs. The study has significant implications for personnel policy and practice in the humanitarian sector. Recruitment officers should have the self-actualized person, as described by Maslow, in mind when interviewing candidates. This perspective would make it easier for them to understand the candidates' thoughts and concerns and would lead to more effective interventions. Program officers should have satisfiers and dissatisfiers, as identified by Herzberg, in mind when planning programs. The probability that personnel will leave humanitarian work is lower if they perceive working conditions as good.

  1. The worker profile autocontrolled

    Directory of Open Access Journals (Sweden)

    Jairo Omar Delgado Mora

    2015-06-01

    Full Text Available This document is part of two deliveries. In this first paper is to make an approach to the concept of self-control from the very beginning with Sakichi Toyoda, founder of what the industry Toyota Motor Company, additionally taking some excerpts of the concept issued by teachers and the psychologist Henry Murray, a professor at the university Harvard precursor test TAT personality test creator, pen applied world wide by psychologists David McCllelan, also a psychologist and a pioneer in the study of human needs and the concept of competence; Professor Jeffrey Pfeffer of Stanford University organizational behavior and theory, Frederick Hertzberg, Psychologist and strong influential in business management, Kronfly Cruz, lawyer and investigator of social and administrative sciences, Charles Perrow, a sociologist at Yale University and Stanford , who studies the impact of large organizations in society, among others. The study reflects the need to meet organizational objectives related to the physicochemical characteristics of the finished product in a plant of the company’s main beers in the country. In this paper, we intend to make an approximation of worker self -controlled, which when compared with the powers, generic, specific and technical area established by the brewery, will allow generating a methodology to adjust these competencies and to obtain the target profile drawn. This comparison and development of the methodology proposed is the subject of the second work planned.

  2. Microprocessing in European High Energy Physics Experiments - ECFA Working Group on Data Processing Standards - Report of the Microprocessor Subgroup May 1982

    CERN Document Server

    European Committee for Future Accelerators (ECFA)

    1982-01-01

    This document contains two reports on the use of microprocessors in European High-Energy Physics experiments. The first is a presentation of data collected by a sub-group of the ECFA working group on data procesing standards. The working group is organised by E. Lillestol, University of Bergen and E.M. Rimmer, CERN, DD Division; the Microprocessor sub-group organiser is L.O. Hertzberger, NIKHEF, Amsterdam. Data are given from projects numbered 81 - 194, and some CERN projects are included. Even though there is some duplication of information, a second report has been appended which covers a wider range of CERN projects. This was the result of a microprocessor survey made at CERN by P. Scharff-Hansen, DD Division, at the request of E. Gabthuler. The ECFA working group intends to have reports for all the sub-groups (10 in number) available in machine-readable form at the CERN computer centre. However, it was felt that the information herein is most valuable to designers and users of microprocessors, and that it...

  3. Mirror symmetry and vibrational structure in optical spectra of chlorophyll a.

    Science.gov (United States)

    Rätsep, Margus; Linnanto, Juha; Freiberg, Arvi

    2009-05-21

    The absorption and fluorescence emission spectra of chlorophyll a in different organic solvents where the central Mg atom is either penta- or hexacoordinated have been studied using conventional and selective spectroscopy methods at ambient and cryogenic temperatures. A breakdown of the basic model mirror-symmetry rule in relation to the lowest-energy Q(y) transitions was observed due to Franck-Condon and Hertzberg-Teller interactions. Detailed vibrational structure in the ground electronic state, virtually independent of the Mg coordination state, was revealed by hole-burning fluorescence line-narrowing technique. The total Huang-Rhys factor associated with the linear vibronic coupling strength of the solvent collective vibrations and the local chlorophyll a intramolecular vibrations is equal to 0.53+/-0.07 in fluorescence and to 0.39+/-0.05 in absorption. The electron-phonon coupling part was also found to depend on the excitation wavelength within the inhomogeneously broadened absorption origin band, its average value being S(ph) approximately = 0.38. All these numbers qualify for the weak vibronic coupling. A comparison of the conjugate Q(y) absorption and fluorescence emission spectra as well as the temperature dependence of the absorption spectra allowed unambiguous locating of the still controversial Q(x) absorption band position for penta- and hexacoordinated chlorophyll a species. The basic experimental findings have been qualitatively supported by semiempirical quantum chemical calculations.

  4. Two-factor theory – at the intersection of health care management and patient satisfaction

    Directory of Open Access Journals (Sweden)

    Bohm J

    2012-10-01

    Full Text Available Josef BohmHealth Services Administration, New York City College of Technology, City University of New York, Brooklyn, NY, USAAbstract: Using data obtained from the 2004 Joint Canadian/United States Survey of Health, an analytic model using principles derived from Herzberg’s motivational hygiene theory was developed for evaluating patient satisfaction with health care. The analysis sought to determine whether survey variables associated with consumer satisfaction act as Hertzberg factors and contribute to survey participants' self-reported levels of health care satisfaction. To validate the technique, data from the survey were analyzed using logistic regression methods and then compared with results obtained from the two-factor model. The findings indicate a high degree of correlation between the two methods. The two-factor analytical methodology offers advantages due to its ability to identify whether a factor assumes a motivational or hygienic role and assesses the influence of a factor within select populations. Its ease of use makes this methodology well suited for assessment of multidimensional variables.Keywords: two-factor theory, behavioral theory, sociology of health care, patient satisfaction

  5. Propos autour d’un inventaire : quelques peintures italiennes à Bastia

    Directory of Open Access Journals (Sweden)

    Michel-Edouard Nigaglioni

    2005-09-01

    Full Text Available Du Moyen Age à la fin du XVIIIe siècle, Bastia fut une ville italienne dépendant de la république de Gênes. C’est pourquoi les églises de la ville conservent encore nombre de toiles d’artistes génois (Ottavio Cambiaso, Domenico Piola, Giuseppe Badaracco ou provenant de régions italiennes proches de la Corse (Giovanni Bilivert. En 1844, le legs du cardinal Fesch, oncle de Napoléon, fait entrer dans les collections municipales une centaine de tableaux italiens. Des restaurations récentes (Lavinia Fontana et une reconsidération globale du fonds, rendue possible par l’inventaire du mobilier appartenant à la ville, permettent découvertes et propositions d’attribution (Francesco Brizio, Giuseppe Bonito….From the Middle Ages up to the end of the eighteenth century, Bastia was an Italian city belonging to the Republic of Genoa. This is why the churches of the city conserve several paintings by artists of Genoese origin (Ottavio Cambiaso, Domenico Piola, Giuseppe Badaracco or coming from other regions in Italy close to Corsica (Giovanni Bilivert. In 1844, a bequest by Cardinal Fesch (Napoleon’s uncle also brought about a hundred Italian paintings to the collections of the city. Some recent restoration work (Lavinia Fontana and a new, general view of the corpus of paintings, helped by the inventory of the furniture belonging to the city, has given rise to some discoveries and also allows for the authors of certain paintings to be identified (Francesco Brizio, Guiseppe Bonito….

  6. [Constant Duméril (1774-1860) anatomist doctor and naturalist, about a portrait by G. Devers].

    Science.gov (United States)

    Le Floch-Prigent, P

    2008-12-01

    André, Marie, Constant Duméril (1774-1860) served as a professor in the from 1801 to 1855. He was also chairman of herpetology and ichthyology of the in Paris. The Paris-Descartes University (department of anatomy) owns a great, framed portrait which is an oil painting by Giuseppe Devers, 1855, representing C. Duméril sat on a chair. The study of his portrait, biography and bibliography brings precisions on a noticeable scholar of the anatomical and naturalistic field in Paris in the first half of the 19th century.

  7. Otto R. Gottlieb e as conexões com o Brasil de Ernest Wenkert

    Directory of Open Access Journals (Sweden)

    Angelo C. Pinto

    2012-01-01

    Full Text Available Prof. Ernest Wenkert's connections with Brazil on this side of the Atlantic Ocean involved two important links: Profs. Jayr de Paiva Campello and Otto R. Gottlieb. The former, along with Prof. Giuseppe Cilento, was one of those responsible for setting up the Institute of Chemistry of UNICAMP, while Otto Gottlieb was the great pioneer of Natural Products Chemistry in Brazil. The bridge between these two professors and Wenkert paved the way for several Brazilian chemists to visit the USA, and was also important for bringing some PhDs to Brazil.

  8. History of the early dipteran systematics in Italy: from Lyncei to Battista Grassi.

    Science.gov (United States)

    Baccetti, B

    2008-12-01

    This presentation starts with Galileo's discovery of the microscope and the first Lyncei. Giovanni Heckius and Francesco Stelluti demonstrated different kinds of mosquitoes. Later, in Florence, the Academy of Cimento solved the problem of mosquito reproduction with the discoveries of Francesco Redi, Pietro Paolo da Sangallo, Giuseppe Del Papa and Giovanni Maria Lancisi in the 18th century. In 19th century Eugenio Ficalbi reviewed the Italian Culicids. Once Battista Grassi solved the cycle of Anopheles and Plasmodia, further researches followed by Golgi, Celli, Marchiafava, Bastianelli and Bignami, as well as by Roland Ross.

  9. Université de Genève | Séminaire de physique corpusculaire | 26 February

    CERN Multimedia

    2014-01-01

    Neutrino physics in the Planck era, Prof. Gennaro Miele, University of Naples   Wednesday 26 February 2014, 11:15 a.m. Science III, Auditoire 1S081 Boulevard d’Yvoy, 1211 Genève 4 Abstract: I briefly summarize the status of art about the properties of relic neutrino distributions and the implications of different neutrino scenarios on cosmological observables after the first measurements by Planck. In particular, I will pay particular attention to the effects due to neutrino-antineutrino asymmetry and to the presence of sterile degrees of freedom. Organised by Prof. Teresa.Montaruli@unige.ch and Prof. Giuseppe.Iacobucci@unige.ch. More information here.

  10. Il Ruolo presidenziale e la distinzione tra funzioni di garanzia e funzioni d’indirizzo politico

    OpenAIRE

    Chessa, Omar

    2010-01-01

    Sommario: 1. Un modello interpretativo ricorrente; 2. Atti composti e atti complessi; 3. La concezione garantistica di Serio Galeotti; 4. La separatezza tra «indirizzo politico presidenziale» e «indirizzo politico governativo» nel pensiero di Giuseppe Guarino; 5. Il Capo dello Stato come organo di «indirizzo politico costituzionale» nel pensiero di Paolo Barile; 6. La distinzione tra indirizzo e garanzia come nuovo fondamento della concezione polifunzionale; 7. La dubbia distinzione tra «atti...

  11. La arquitectura como texto: el Danteum, entre la selva y el paraíso

    OpenAIRE

    Torres Paredes, Edgar A.

    2009-01-01

    1. May 1983. Rino Valdameri, director of the Accademia di Belle Arti di Brera (the Brera Academy of Fine Arts), and Senator Alessandro Poss, propose to the authorities of the city of Rome a monument in honour of the most celebrated poet of Italians. This project is entrusted to architects Pietro Lingeri and Giuseppe Terragni, and is given the name Danteum. In October 1938, architects and promoters were called on Thursday 10th November, at 5.30pm, at Palazzo Ducale di Venezia (Doge¿s Palace) ...

  12. Benedetto Croce y La mia filosofia

    Directory of Open Access Journals (Sweden)

    Lino Di Stefano

    2015-07-01

    Full Text Available El presente texto plantea algunas cuestiones sobre la colección de ensayos de Benedetto Croce La mia filosofia. Publicado en 1993, cincuenta años después de su redacción, la edición del texto es sin duda, como señala el editor Giuseppe Galasso, una magnífica ocasión para acercarse a unos textos hasta ahora inéditos en los que el pensador napolitano reflexiona sobre sí mismo al tiempo que para entresacar algunos de los rasgos de su propia producción filosófica.

  13. Fully Human and Fully Divine: The Birth of Christ and the Role of Mary

    OpenAIRE

    Ann Milliken Pederson; Gretchen Spars-McKee; Elisa Berndt; Morgan DePerno; Emily Wehde

    2015-01-01

    The task given to us for this article was to offer theological responses to, “Can modern biology interpret the mystery of the birth of Christ?” by Giuseppe Benagiano and Bruno Dallapiccola. We are female Protestant theologians and respond to the issues from this perspective. The Christian confession of the virgin birth of Jesus (stated within the Apostles and Nicene creeds) is a statement of faith that God became incarnate through the power of the Holy Spirit in the flesh of the human Jesus a...

  14. Fuels, energy, and the environment

    CERN Document Server

    Karim, Ghazi A

    2012-01-01

    All complicated materials of combustion science are presented in a very clear and precise manner … This is the book, in my opinion, that every combustion, fire safety, and fuel engineer should have. … equally useful to newcomers … [and] experienced professionals and researchers in the area.-S.O. Bade Shrestha, Western Michigan University The book covers all aspects of fuels, not just … chemistry or combustion. Of particular importance and actuality are those issues related to safety and environmental impact. Furthermore, the variety of fuels and processes discussed is very wide.-Giuseppe Spazz

  15. Análisis para el cumplimiento de las medidas socioculturales de mitigación del proyecto hidroeléctrico angostura en su etapa constructiva

    OpenAIRE

    Elizondo Salas, Marilú; Núñez Mata, Oscar

    2013-01-01

    “Si queremos que todo continúe igual, las cosas deben cambiar”, frase célebre de Giuseppe Tommasi Di Lampedusa, escritor y aristócrata italiano, la cual parece describir muy bien la justificación para realizar las Evaluaciones de Impacto Ambiental (EIA) en los proyectos de inversión, como medida ambiental explícita. Rara vez una EIA logra modificar sustancialmente un proyecto y, en contadas ocasiones rechazarlo; sin embargo, muchos países las han puesto en práctica con el objetivo de dismi...

  16. One of the two end-cap vacuum chambers for the CMS experiment has been completed.

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    This 7.5-metre-long cone-shaped object is the fruit of many years' development and its machining and assembly were performed with the utmost precision. Part of the team involved in the design and production of the end-cap vacuum chamber for CMS, standing behind the completed segment. Picture 02 from left to right : Thierry Tardy (TS/MME), Luigi Leggiero (TS/MME), Patrick Lepeule (AT/VAC), Gérard Faber (ETH Zürich), Stefano Bongiovani (CINEL Project Manager), Giuseppe Foffano (TS/MME) and Marc Thiebert (TS/MME).

  17. CERN Scuba Diving Club

    CERN Multimedia

    Club Subaquatique du CERN

    2017-01-01

    Interested in scuba diving? Fancy a fun trial dive? Like every year, the CERN Scuba Diving Club is organizing two free trial dive sessions. Where? Varembé Swimming Pool, Avenue Giuseppe Motta 46, 1202 Genève When? 25th October and 1st November at 19:15 (one session per participant) Price? Trial dives are FREE! Swimming pool entrance 5,40 CHF. What to bring? Swimwear, towel, shower necessities and a padlock – diving equipment will be provided by the CSC. For more information and to subscribe, follow the link below: http://cern.ch/csc-baptemes-2017 Looking forward to meeting you!

  18. Infraspinatus strength assessment and ultrasound evaluation of posterior capsulotenodesis after arthroscopic hill-sachs remplissage in traumatic anterior glenohumeral instability: a retrospective controlled study protocol.

    Science.gov (United States)

    Merolla, Giovanni; Porcellini, Giuseppe

    2014-04-01

    Giovanni Merolla Co-investigator: Giuseppe Porcellini Investigation performed at the Biomechanics Laboratory "Marco Simoncelli", D. Cervesi Hospital, Cattolica - Italy PLAN OF CLINICAL INVESTIGATION (PCI): Version 1.0 of June 12, 2012 Approved by AV/IRST Ethical Committee (Comitato Etico Area Vasta Romagna) and authorized by AUSL RN ("Determina AUSL Rimini numero 326 del 29/03/2013: Remplissage U.O Chirurgia della Spalla - Valutazione clinica ed ultrasonografica dell'infraspinato dopo capsulo-tenodesi artroscopica (remplissage) nell'instabilità anteriore traumatica di spalla con lesione di Bankart e difetto omerale di Hill-Sachs").

  19. 意大利设计师在上海

    Institute of Scientific and Technical Information of China (English)

    黄岳; Rocky

    2006-01-01

    Fulvio Giuliano更像个大学教授,斯文而且还有几分腼腆。这位又瘦又高的意大利人从给自己起了个中文名字叫朱理安,正式开始了他的中国生活。尽管朱赛(Giuseppe Santarcangelo)自己说“我每个月15天在上海,15天在意大利,只能算半个上海人”,他还是固执地坚持不要把他当作个外国人来看。

  20. Peripheral artery disease: potential role of ACE-inhibitor therapy

    Directory of Open Access Journals (Sweden)

    Giuseppe Coppola

    2008-12-01

    Full Text Available Giuseppe Coppola, Giuseppe Romano, Egle Corrado, Rosa Maria Grisanti, Salvatore NovoDepartment of Internal Medicine, Cardiovascular and Nephro-Urological Diseases, Chair of Cardiovascular Disease, University of Palermo, Palermo, ItalyAbstract: Subjects with peripheral arterial disease (PAD of the lower limbs are at high risk for cardiovascular and cerebrovascular events and the prevalence of coronary artery disease in such patients is elevated. Recent studies have shown that regular use of cardiovascular medications, such as therapeutic and preventive agents for PAD patients, seems to be promising in reducing long-term mortality and morbidity. The angiotensin-converting-enzyme (ACE system plays an important role in the pathogenesis and progression of atherosclerosis, and ACE-inhibitors (ACE-I seem to have vasculoprotective and antiproliferative effects as well as a direct antiatherogenic effect. ACE-I also promote the degradation of bradykinin and the release of nitric oxide, a potent vasodilator; further, thay have shown important implications for vascular oxidative stress. Other studies have suggested that ACE-I may also improve endothelial dysfunction. ACE-I are useful for reducing the risk of cardiovascular events in clinical and subclinical PAD. Particularly, one agent of the class (ie, ramipril has shown in many studies to able to significantly reduce cardiovascular morbidity and mortality in patients with PAD.Keywords: atherosclerosis, peripheral arterial disease, endothelial dysfunction, ACE-inhibitors

  1. A note of thanks

    Directory of Open Access Journals (Sweden)

    Stefania Boccia

    2013-12-01

    Full Text Available The editors-in-chief, editors, members of the editorial board and publisher of Epidemiology, Biostatistics and Public Health wish to express their sincere gratitude to the referees of the articles considered for the 2013 volume of the Journal. Giuseppe Arbia Fabio Barbone Joana Bastos Stefania Boccia Anna BossiSilvio BrusaferroChiara CadedduCaterina CaminitiGiovanni CapelliGuido CitoniGianfranco DamianiAntonio De BelvisEmma De FeoElisabetta De VitoChiara de WaureDomitilla Di ThieneAna DuarteBruno Federico Monica Ferraroni Alessandra Frustaci Carlotta Galeone Silvano Gallus Maurizio Genuardi Guglielmo Giraldi Maria Rosaria Gualano Carolina Ianuale Farhad Islami Giuseppe La Torre Patrizia Laurenti Laura Lauria Carlo La Vecchia Emanuele Leoncini Alice Mannocci Walter Mazzucco Silvia Miccoli Cristina Montomoli Eva Negri Nicola Nicolotti Caterina Palazzo GianCarlo Paradisi Patrizio Pasqualetti Claudio Pelucchi Brunella Posteraro Delphine Praud Gianluigi Quaranta Luca Sbrogiò Benedetto Simone Giuliana Solinas Maria Lucia Specchia Annamaria Tortorano Fabio TuroneBrigid UnimMaria Assunta Veneziano Francesco Vitale Antonella Zambon Alessandro Zanetti.

  2. Glossario per la città europea / Glossary for the European city

    Directory of Open Access Journals (Sweden)

    Yannis Tsiomis

    2014-09-01

    Full Text Available Il concetto di “città in estensione” di Giuseppe Samonà è l'occasione per riflettere sul significato del fenomeno urbano oggi. L’autore lo fa attraverso nove punti, da “estensione” a “polisemia”, passando per “scala”, “metodo” e “funzione”, che diventano i termini di un nuovo glossario ragionato per la città europea, per un approccio cosciente allo studio e al progetto di quello che lui chiama “il dilemma territoriale”. / Giuseppe Samonà's idea of the "city in extension" offers the occasion to reflect on the meaning of the urban phenomenon today. The author does so through nine points, from “extension” to “polysemy”, passing via “scale”, “method” and “function”, which become the terms of a new reasoned glossary for the European city, for an aware approach to studio and the project of what he calls “the territorial dilemma”.

  3. Enlightening music: the catalogue and digitisation project of Verdi’s archive at the “Archivio Storico Ricordi” in Milan

    Directory of Open Access Journals (Sweden)

    Mathias Balbi

    2014-05-01

    Full Text Available Our contribution concentrates on the processes of cataloguing and digitising of hand–written letters and business documents belonging to the ''Ricordi Historical Archive'' in Milan, which is at present housed in the Braidense National Library; the archive possesses documents referring to the history of the publishing company covering the two centuries of its activities. Starting from the ledgers compiled by Giovanni Ricordi, which cover a period from 1814 up to the middle of the 19th century to the documents relative to the school of engraving, the archive also houses a large number of editorial catalogues, published by Ricordi and by other publishing houses which it took over, as well as the original contracts stipulated with composers and librettists from Giuseppe Verdi and Giacomo Puccini to Arrigo Boito. The collection of about 15,000 hand–written letters covers the period from the beginning of the 19th century to the end of the 20th century and includes documents sent to Ricordi from writers, singers authors, and composers such as Giuseppe Verdi, Giacomo Puccini and Ottorino Respighi and librettists Luigi Illica, Giuseppe Giacosa and Arrigo Boito. The second part of the correspondence is made up letter–books and business correspondence which were kept intact from 1888 to 1962, except for the period from 1944 to 1953. Since 2006, work has been carried out to catalogue and digitise the Ricordi Archive based on the standards set out by the National Library Service (Servizio Bibliotecario Nazionale – SBN which is head of the Central Institute for the Single Catalogue (ICCU. The structure and use of the archive and the external transmission of its contents are safeguarded and enhanced thanks to the combined work of cataloguing and digitisation of this heritage: the preliminary cataloguing of the documents uses a simplified model of the scheme adopted in the description of the manuscript according to sw Manus, elaborated by ICCU: the

  4. Enlightening music: the catalogue and digitisation project of Verdi’s archive at the “Archivio Storico Ricordi” in Milan

    Directory of Open Access Journals (Sweden)

    Mathias Balbi

    2014-07-01

    Full Text Available Our contribution concentrates on the processes of cataloguing and digitising of hand–written letters and business documents belonging to the ''Ricordi Historical Archive'' in Milan, which is at present housed in the Braidense National Library; the archive possesses documents referring to the history of the publishing company covering the two centuries of its activities.Starting from the ledgers compiled by Giovanni Ricordi, which cover a period from 1814 up to the middle of the 19th century to the documents relative to the school of engraving, the archive also houses a large number of editorial catalogues, published by Ricordi and by other publishing houses which it took over, as well as the original contracts stipulated with composers and librettists from Giuseppe Verdi and Giacomo Puccini to Arrigo Boito. The collection of about 15,000 hand–written letters covers the period from the beginning of the 19th century to the end of the 20th century and includes documents sent to Ricordi from writers, singers authors, and composers such as Giuseppe Verdi, Giacomo Puccini and Ottorino Respighi and librettists Luigi Illica, Giuseppe Giacosa and Arrigo Boito. The second part of the correspondence is made up letter–books and business correspondence which were kept intact from 1888 to 1962, except for the period from 1944 to 1953. Since 2006, work has been carried out to catalogue and digitise the Ricordi Archive based on the standards set out by the National Library Service (Servizio Bibliotecario Nazionale – SBN which is head of the Central Institute for the Single Catalogue (ICCU. The structure and use of the archive and the external transmission of its contents are safeguarded and enhanced thanks to the combined work of cataloguing and digitisation of this heritage: the preliminary cataloguing of the documents uses a simplified model of the scheme adopted in the description of the manuscript according to sw Manus, elaborated by ICCU: the

  5. Note e Recensioni

    Directory of Open Access Journals (Sweden)

    a cura di Mariagrazia Portera

    2013-12-01

    Full Text Available Volumi Winfried Menninghaus, La promessa della bellezza, [Fabrizio Desideri, p. 272] • David Rothenberg, Survival of the Beautiful. Art, Science and Evolution [Danae Crocchiola, p. 274] • Lev Manovich, Software Takes Command [Angela Maiello, p. 277]. Note Method in Aesthetics: Philosophy, Evolution and the Cognitive Sciences [Aaron Meskin, Matthew Kieran, Gregory Currie, p. 280] • L’Abitare possibile. Estetica, Architettura e New Media, Ravello, Auditorium Oscar Niemeyer, 28-30 maggio 2013 [Sara Matetich, p. 282] • Copenhagen Summer School in Phenomenology and Philosophy of Mind, University of Copenhagen, 12-16 Agosto 2013 [Raoul Frauenfelder, p. 289] • Ciò che è vivo e ciò che è morto nell’estetica di Archibald Ali- son. Nota a margine del convegno: Neoestetica ed emozione. Archibald Alison e l’estetica con- temporanea, Palermo, 4-5 ottobre 2013 [Giuseppe Pucci, p. 294

  6. Preface

    Directory of Open Access Journals (Sweden)

    Silvio Seno

    2012-07-01

    Full Text Available It is my distinguished pleasure to introduce this volume devoted to geoethics and edited by Silvia Peppoloni and Giuseppe Di Capua, for two main reasons. First and foremost, the volume is a collection of papers presented during the ‘Geoethics’ scientific session at the 8th Italian Forum of Earth Sciences that was held in September 2011, in Turin, Italy. The Forum singled out sustainability – “Earth Sciences for sustainable development” – as its main theme, thus highlighting the key role of the geosciences with respect to important issues for the present, and in particular, for the future of our society. Resources and energy, climate, water, impact reduction of natural hazards, new materials, and protection and conservation of cultural heritage are all aspects of interest where a (geoethical approach is strongly needed. [...

  7. Outcome of Short Period and Intermittent ImatinibPhased Chemotherapy (Northern Italy Leukemia Group Protocol 09/00) as Therapy for Ph+ ALL%短程、间歇伊马替尼联合传统化疗(N ILG09/00方案)在Ph+ ALL治疗中的作用

    Institute of Scientific and Technical Information of China (English)

    杜欣; 凌伟

    2011-01-01

    1 文献来源Renato B,Giuseppe R,Enrico MP,et al.Chemotherapy-phased Imatinib pulses improve longterm outcome of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia:Northern Italy leukemia group protocol 09/00[J].J Clin Oncol,2010,28(22):3644-3652.2 证据水平3a.3背景·作为一种ABL1酪氨酸激酶抑制剂,伊马替尼在费城染色体(Philadelphia chromosome,Ph)阳性急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)患者的治疗中担当重要角色.%Department of Hemalology, Cancer Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China

  8. Venous thromboembolism and pregnancy

    Directory of Open Access Journals (Sweden)

    Maristella D’Uva

    2010-03-01

    Full Text Available Maristella D’Uva1, Pierpaolo Di Micco2, Ida Strina1, Giuseppe De Placido1Department of Obstetrics and Gynecology and Human Reproduction, “Federico II” University of Naples, Naples, Italy; 2Internal Medicine Division, Buonconsiglio Fatebenefratelli Hospital of Naples, Naples, ItalyAbstract: In recent decades, the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL has been studied extensively. Although the first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication such as venous thromboembolism (VTE during pregnancy. Thromboprophylaxis should be considered also for pregnant subjects carriers of molecular thrombophilia or that previously experienced VTE, in order to prevent VTE during pregnancy, while antithrombotic treatment for VTE should be performed during all pregnant periods.Keywords: thrombophilia, venous thromboembolism, recurrent pregnancy loss, factor V Leiden

  9. Alberto Anile, Maria Gabriella Giannice, Operazione Gattopardo. Come Visconti trasformò un romanzo di “destra” in un successo di “sinistra”

    OpenAIRE

    Wehrli, Delphine

    2015-01-01

    À plus de cinquante ans de sa publication, le Guépard de Giuseppe Tomasi di Lampedusa reste un des cas littéraires majeurs de l’après-guerre, que ce soit pour son incroyable succès de public (au point d’atteindre en juillet 1959 les 70 000 exemplaires vendus et l’attribution du Prix Strega) ou pour les vives discussions qu’il suscita auprès de la critique. L’« Opération Guépard », ou comment un roman de « droite » s’est transformé en un succès de « gauche », est le titre de l’ouvrage d’Anile ...

  10. Highlights from e-EPS: the 2015 EPS High Energy Physics Prize winners

    CERN Multimedia

    Thomas Lohse, e-EPS News

    2015-01-01

    The EPS High Energy Physics Division announces the winners of its 2015 prizes, which will be awarded at the Europhysics Conference on High-Energy Physics (EPS-HEP 2015), Vienna (Austria) 22−29 July. Many people from CERN were among the winners.   The 2015 High Energy and Particle Physics Prize, for an outstanding contribution to High Energy Physics, is awarded to James D. Bjorken “for his prediction of scaling behaviour in the structure of the proton that led to a new understanding of the b interaction”, and to Guido Altarelli, Yuri L. Dokshitzer, Lev Lipatov, and Giorgio Parisi “for developing a probabilistic field theory framework for the dynamics of quarks and gluons, enabling a quantitative understanding of high-energy collisions involving hadrons”. The 2015 Giuseppe and Vanna Cocconi Prize, for an outstanding contribution to Particle Astrophysics and Cosmology in the past 15 years, is awarded to Francis Halzen “for his visiona...

  11. Toward a formal ontology for narrative

    Directory of Open Access Journals (Sweden)

    Ciotti, Fabio

    2016-03-01

    Full Text Available In this paper the rationale and the first draft of a formal ontology for modeling narrative texts are presented. Building on the semiotic and structuralist narratology, and on the work carried out in the late 1980s by Giuseppe Gigliozzi in Italy, the focus of my research are the concepts of character and of narrative world/space. This formal model is expressed in the OWL 2 ontology language. The main reason to adopt a formal modeling approach is that I consider the purely probabilistic-quantitative methods (now widespread in digital literary studies inadequate. An ontology, on one hand provides a tool for the analysis of strictly literary texts. On the other hand (though beyond the scope of the present work, its formalization can also represent a significant contribution towards grounding the application of storytelling methods outside of scholarly contexts.

  12. Gramsci no seu e no nosso tempo

    Directory of Open Access Journals (Sweden)

    Cássio Augusto Samogin Almeida Guilherme

    2011-04-01

    Full Text Available Resenha: AGGIO, Alberto; HENRIQUES, Luiz Sérgio; VACCA, Giuseppe (org.. Gramsci no seu tempo. Brasília: Fundação Astrogildo Pereira; co-edição – Rio de Janeiro: Contraponto, 2010

  13. Université de Genève | Séminaire de physique corpusculaire | 15 May

    CERN Multimedia

    2013-01-01

    Thorium or Uranium fuel cycle for advanced nuclear reactors ? Fuel recycling, multi-recycling, breeding and burning, Dr Jiri Krepel, Paul Scherrer Institut (PSI).   Wednesday 15 May, 11:15 a.m. Science III, Auditoire 1S081 30, quai Ernest-Ansermet, 1211 Genève 4 Abstract: The Thorium fuel cycle provides several advantages, which make it very attractive; e.g. lower waste production and possibly improved reactor safety. However, there are also some drawbacks if compared with the Uranium cycle. The seminar will provide an overview of the basic physical features of both the Thorium and the Uranium fuel cycles and comparison of their performance (criticality, breeding gain) and safety-related parameters (Doppler effect, coolant density effect), with respect to fuel recycling, multi-recycling, breeding and burning. Organised by Prof. Teresa.Montaruli@unige.ch and Prof. Giuseppe.Iacobucci@unige.ch. More information here.

  14. Université de Genève | Séminaire de physique corpusculaire | 6 November

    CERN Multimedia

    2013-01-01

    Particle sensors in CMOS Technologies, Dr Ivan Peric, Heidelberg University.   Wednesday 6 November 2013, 11:15 a.m. Science III, Auditoire 1S081 Boulevard d’Yvoy, 1211 Genève 4 Abstract: The use of pixel sensors implemented in standard CMOS technologies has gained in popularity over the last decade. The most prominent application is consumer electronics – the sensors for digital cameras. CMOS sensors are also a promising option for high energy physics. An overview of existing CMOS detector structures for particle tracking will be given, and their properties compared. Organised by Prof. Teresa.Montaruli@unige.ch and Prof. Giuseppe.Iacobucci@unige.ch. More information here.

  15. The Antinous Braschi on Engraved Gems: An Intaglio by Giovanni Beltrami

    Directory of Open Access Journals (Sweden)

    Hadrien J. Rambach

    2014-02-01

    Full Text Available Un grande quarzo citrino inciso è stato di recente venduto all’asta, in America, con una descrizione inesatta. Opera di Giovanni Beltrami (Cremona 1770-1854, questo intaglio rappresenta l’Antinoo Braschi. Le gemme incise raffiguranti Antinoo sono piuttosto comuni ma normalmente esse ritraggono il rilievo Albani, la statua capitolina o l’intaglio Marlborough. Il soggetto scelto per questo citrino inedito è, invece, insolito. L’Antinoo Braschi venne ritrovato nel 1793 andando ad arricchire le collezioni pontificie nel 1843. Esso fu molto apprezzato da Giuseppe Girometti (Roma, 1779-1851, che riprodusse il busto dell’Antinoo Braschi su numerosi cammei oggi conservati a Londra, in Vaticano e a Vienna. Anche Luigi Pichler (1773-1854 realizzò un intaglio, oggi perduto, con lo stesso soggetto. Mancando documenti d’archivio, si deve pensare che queste gemme fossero incise per coloro che effettuavano il Gran Tour intorno agli anni 1800-1830.

  16. Cinema on Cinema: The Kinship between Cinema Paradiso and Zıkkımın Kökü, Karpuz Kabuğundan Gemiler Yapmak, Sinema Bir Mucizedir

    Directory of Open Access Journals (Sweden)

    Basak Demiray

    2011-08-01

    Full Text Available This study consists of a comparative analysis of four films which fall under the category of “cinema on cinema”. These films are Cinema Paradiso (Giuseppe Tornatore, 1988, Italy, Zıkkımın Kökü (Memduh Ün, 1993, Turkey, Karpuz Kabuğundan Gemiler Yapmak/ Boats out of Watermelon Rinds ( Ahmet Uluçay, 2004, Turkey, Sinema Bir Mucizedir/ Cinema is a Miracle (Memduh Ün- Tunç Başaran, 2005, Turkey. It will be argued that these films have four main points of similarity. First, they are the instances of “cinema on cinema”; second, they are biographical films; third, their plots are constructed upon the rural lives of the past; fourth, they are about cinephilia.

  17. Women taking the “blue pill” (sildenafil citrate: such a big deal?

    Directory of Open Access Journals (Sweden)

    Lo Monte G

    2014-11-01

    Full Text Available Giuseppe Lo Monte, Angela Graziano, Isabella Piva, Roberto Marci Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, Italy Abstract: For years, phosphodiesterase type 5 inhibitors have been used for the treatment of erectile dysfunctions. Due to the similarities between male and female sexual response, several studies have assessed the effects of sildenafil citrate (Viagra® in women affected by female sexual arousal disorder. The results are still conflicting and the drug is not devoid of adverse effects. Furthermore, female sexual arousal disorder is a heterogeneous condition whose underlying causes are difficult to diagnose and appropriate treatment requires a thorough sexual, psychological, and medical history along with specialist consultations. The clinician should pursue a global approach to the patient with sexual difficulties, while non-hormonal treatment such as phosphodiesterase type 5 inhibitors (ie, sildenafil citrate should be kept as the last option. Keywords: phosphodiesterase type 5 inhibitors, female sexual arousal disorder (FSAD, sildenafil citrate

  18. «Die Blume Heute schmilzt hinweg». Paul Celans Signale zum Ertrinkenstod

    Directory of Open Access Journals (Sweden)

    Jürgen C. Thöming

    2016-06-01

    Full Text Available Numerous readers of Celan, among them Giuseppe Bevilacqua and John Felstiner, have pointed out diverse references to death by drowning. This biographical paper picks up evidence systematically and chronologically, thereby rejecting any «special attraction» to the element of water. By focussing Celan’s poem Kenotaph, we can see a clear connection to the «Goll affair». Only in 1967, when the poem Brunnengräber was written, plans for death by drowning became apparent. Such plans further developed in renditions of Dupin and Rokeah. Gisèle Celan-Lestrange’s graphic Les flots se fermant also deals with this issue. Ce­lan’s personal statements before his death reveal a strong interest in Hölderlin.

  19. Risorse digitali

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2005-12-01

    Full Text Available Bibliotheca Latinitatis Mediaevalis (circa VII sec. - XIV sec. IntraText Digital Library [01/06] Corpus Scriptorum Latinorum. A digital library of Latin literature by David Camden [01/06] Fonti disponibili online concernenti la vita religiosa medievale Rete Vitae Religiosae Mediaevalis Studia Conectens [01/06] Fuentes del Medievo Hispanico Instituto de Historia, Consejo Superior de Investigaciones Científicas [01/06] Latin Literature Forum Romanum [01/06] Ludovico Antonio Muratori, Dissertazioni sopra le antichità italiane, 1751 Biblioteca dei Classici Italiani di Giuseppe Bonghi [01/06] Medieval Latin The Latin Library [01/06] Médiévales Presses Universitaires de Vincennes - Revues.org [01/06] Regesta imperii Deutsche Kommission für die Bearbeitung der Regesta Imperii e.V. [01/06] Suda On Line Byzantine Lexicography [01/06

  20. Voices from the Unknown: The Fantastic in 19th century Music Between Music Insects and Autoparodies

    Directory of Open Access Journals (Sweden)

    Elisabetta Fava

    2014-05-01

    Full Text Available Teatro, musica e letteratura del fantastico sono fortemente connessi fra di loro: non solo per le continue allusioni musicali della narrativa, ma anche per le sollecitazioni di natura letteraria che incoraggiano il delinearsi di un lessico musicale del fantastico. Partendo dal caso dell'Ottetto di Mendelssohn, il cui Scherzo si ispira a un passo del Walpurgisnachtstraum di Goethe, l'intervento mostra l'incidenza di alcuni topoi musicali del fantastico e la possibilità di utilizzarli anche in chiave parodistica, come avviene nel caso della Erste Walpurgisnacht (Goethe-Mendelssohn. La presenza degli insetti musicanti nel passo goethiano lascia a sua volta un'eredità costante in tutta la storia successiva del fantastico: come esempi si citano i quadri conclusivi delle Lustigen Weiber von Windsor di Otto Nicolai (1849 e del Falstaff di Giuseppe Verdi (1893, senza dimenticare situazioni analoghi riscontrabili nella musica russa da Čajkovskij a Skrjabin.

  1. Postille

    Directory of Open Access Journals (Sweden)

    Edoardo Esposito

    2016-07-01

    Full Text Available Le postille di questo numero trattano dei seguenti volumi (fra parentesi il nome del recensore: Philip K. Dick, L’esegesi, a cura di Pamela Jackson - Jonathan Lethem, traduzione di Maurizio Nati, Roma, Fanucci Editore, 2015, pp. 1300; Giulia Iannuzzi, Distopie, Viaggi Spaziali, Allucinazioni. Fantascienza Italiana Contemporanea, prefazione di Pierpaolo Antonello, Milano-Udine, Mimesis, 2015, pp. 355 (Carlo Pagetti Mario Mancini, Stilistica filosofica, Roma, Carocci, 2015, pp. 196 (Carlo Di Alesio Józef Czapski, Proust a Grjazovec, a cura di Giuseppe Girimonti Greco, con un saggio di Wojciech Karpiński, Milano, Adelphi, 2015, pp. 125 (Eleonora Sparvoli Vittorio Sereni, Il dubbio delle forme. Scritture per artisti, a cura e con un saggio di Gianni Contessi, Torino, Aragno, 2015, pp. cviii-135 (Antonio Loreto

  2. LA GEOMETRIA NON-ARCHIMEDEA. DALLE PREMESSE AGLI INFINITI MODELLI ATTUALI

    Directory of Open Access Journals (Sweden)

    R. Mascella

    2006-02-01

    Full Text Available La geometria non-archimedea sembra essere un’ipotesi astratta e fantasiosa, accettabile nella matematica ma non per la rappresentazione spaziale, perché usa concetti a lungo esplorati nel pensiero scientifico e filosofico e spesso rigettati, quali l’infinito e l’infinitesimo attuali. L’articolo analizza gli aspetti storici, epistemologici, filosofici e matematici legati a questa geometria ed alle sue radici, considerando l’impostazione dell’inventore Giuseppe Veronese, della formalizzazione analitica di Levi-Civita e di altri matematici e filosofici che sul tema hanno fornito risultati e dibattuto, quali Cantor, Hilbert e Hahn, per terminare con gli infiniti modelli che oggi conosciamo. Questa geometria appare sottovalutata, ma si presta ad un ruolo non meno importante di alcune alternative non-euclidee, spesso semplicisticamente considerate come uniche varianti astratte dei modelli euclideo e riemanniano.

  3. Patologie sociali, resistenze e difese degli insegnanti nell’istituzione scolastica: Considerazioni cliniche e pedagogiche

    Directory of Open Access Journals (Sweden)

    Tommaso Fratini

    2014-12-01

    Full Text Available L’articolo prende in esame il tema di alcune resistenze e difese degli insegnanti all’interno dell’istituzione scolastica. Partendo dall’attuale condizione di emergenza della scuola italiana e rifacendosi al concetto di patologia sociale di Giuseppe Di Chiara, viene argomentato come tali resistenze coprano le angosce persecutorie degli insegnanti nel loro lavoro scolastico quotidiano nel rapporto con gli allievi. L’articolo, tra le varie forme di patologia istituzionale, affronta principalmente il tema di quelle che presiedono alle resistenze degli insegnanti al lavoro introspettivo con il proprio mondo interno, conseguenza e ulteriore cagione di sensi di colpa nel rapporto con gli allievi e di fenomeni di burnout lavorativo degli stessi insegnanti. Tali fenomeni vanno nella direzione del rinforzo sia di un atteggiamento di chiusura verso la collaborazione con professionisti esterni all’istituzione scolastica, sia di un atteggiamento di minore empatia e vicinanza emotiva con la realtà interna degli allievi.

  4. 'A treatise on optics' by Giovanni Christoforo Bolantio.

    Science.gov (United States)

    Bedini, S A; Bennett, A G

    1995-03-01

    Few accounts have survived detailing the techniques employed for the production of optical glass for astronomical and microscopical instruments during the seventeenth century in Italy; the period during which the art was being developed in the shops of Eustacho Divini and Giuseppe Campani, and other optical instrument-makers. Indeed, few of the tools of the lens-makers have been described in any detail, and few if any have survived. Consequently, the discovery of a hitherto apparently unknown Italian treatise, or what appears to have been notes for a shop manual of the period, is a contribution to present knowledge of lens-making technology even though the identity and region of the author remain unknown.

  5. In memory of a Maestro

    Directory of Open Access Journals (Sweden)

    Luigi Bodria

    2013-03-01

    Full Text Available Seldom the qualification of Maestro may find more appropriate use that in the case of Giuseppe Pellizzi, Emeritus Professor at the University of Milano, died suddenly last summer. His contribution of enthusiasm and intelligence, his strong personality and commitment has deeply influenced at national and international level the agricultural engineering community and is death has left a gap that cannot be filled in all whose who have had the chance and the privilege of working alongside. Thanks to his uncommon ability to attract and motivate young people, fascinating them with his intellectual dynamism and making them feel important and vital part of the Institute and its projects, he was a master of great charisma who led the training and scientific growth of numerous young researchers...

  6. Boscovich: scientist and man of letters

    Science.gov (United States)

    Proverbio, E.

    Ruggiero Giuseppe Boscovich (1711-1781) is known as one of the most important scientists of the second half of XVIII century, but he was active also as a man of letters, especially through an abundant production of poems in Latin verse. We try to interpret these two, apparently antinomic, aspects of his character in the framework of the culture of his epoch, in which science and literary productions were not considered as two separate or opposite fields, but only two different aspects of human knowledge. In particular we review the field of his poetic production in which this fundamental unity of knowledge is most evident, namely his poems with didactic-scientific subjects, which are examples of high-level popularization of the latest progresses in science (in particular astronomy and Newtonian physics) by means of elegant Latin verse.

  7. 柯达医疗携众款高端产品亮相china med2007

    Institute of Scientific and Technical Information of China (English)

    吴马

    2007-01-01

    不久前,在2007国际医疗设备展览会上,柯达医疗集团隆重举行了主题为“科技巅峰,征服未来”的其最新产品征服者DR9500的新品发布会,柯达医疗集团总裁kevin hobert先生以柯达医疗便于DG产品市场经理Giuseppe Giuliano先生、柯达医疗集团大中华区总经理刘杰先生、柯达医疗亚太区DR产品经理李征先生共同揭开了DR9500的神秘面纱。

  8. European Archaeomagnetism: Progress and Problems

    Science.gov (United States)

    Evans, M. E.; Hoye, G.

    2009-05-01

    Much progress has been made since the seminal work of Giuseppe Folgheraiter (1856-1913) in the late 19th century. So much so that recent advances now make it possible to draw up complete isogonic and isoclinic maps for Europe and adjacent areas spanning the last three millennia (Pavon-Carrasco et al., 2009). Results based on multiple independent studies, with high precision and good age control are crucial and should be recognized as "anchor points" (e.g. Pompeii). On the other hand, the nagging problem of outliers persists. Among the possible causes are magnetic refraction, physical distortion, and inadequate chronological control. Some examples, drawn from our own investigations over the last 30 years, will be discussed in detail. These include previously unpublished data from a detailed study (more than 100 samples) of a kiln in southern Italy, and an apparently good (but aberrant) archaeodirection from a kiln in southern Spain.

  9. Digital resources

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2005-12-01

    Full Text Available Bibliotheca Latinitatis Mediaevalis (circa VII sec. - XIV sec. IntraText Digital Library [01/06] Corpus Scriptorum Latinorum. A digital library of Latin literature by David Camden [01/06] Fonti disponibili online concernenti la vita religiosa medievale Rete Vitae Religiosae Mediaevalis Studia Conectens [01/06] Fuentes del Medievo Hispanico Instituto de Historia, Consejo Superior de Investigaciones Científicas [01/06] Latin Literature Forum Romanum [01/06] Ludovico Antonio Muratori, Dissertazioni sopra le antichità italiane, 1751 Biblioteca dei Classici Italiani di Giuseppe Bonghi [01/06] Medieval Latin The Latin Library [01/06] Médiévales Presses Universitaires de Vincennes - Revues.org [01/06] Regesta imperii Deutsche Kommission für die Bearbeitung der Regesta Imperii e.V. [01/06] Suda On Line Byzantine Lexicography [01/06

  10. Keeping our eyes on the eyes: the case of Arcimboldo.

    Science.gov (United States)

    Bubic, Andreja; Susac, Ana; Palmovic, Marijan

    2014-01-01

    While contemporaries often viewed his reversible composite heads as scherzi (jokes) and modem art connoisseurs as creative masterpieces, Giuseppe Arcimboldo's ingenious paintings served as inspiring stimuli for the present eye-tracking experiment. One group of participants viewed three chosen paintings in an upright, and another in an upside-down, orientation. We compared how participants viewed three selected areas of interest (AOIs) within the painting when these could, and could not, be identified as a face or distinct facial element (eyes and mouth). The obtained results indicate that the participants fixated the parts of the painting which represent faces more in the upright than in the inverted orientation. Furthermore, in the upright orientation the participants focused more on the upper AOls (eyes) than the lower AOIs (mouth). This was not the case for the inverted orientation of two paintings. In conclusion, the face inversion effect occurs even in this artistic context, and the gaze often goes where the eyes are.

  11. Factors influencing choice of chemotherapy in metastatic colorectal cancer (mCRC

    Directory of Open Access Journals (Sweden)

    Rossi L

    2013-11-01

    Full Text Available Luigi Rossi, Foteini Vakiarou, Federica Zoratto, Loredana Bianchi, Anselmo Papa, Enrico Basso, Monica Verrico, Giuseppe Lo Russo, Salvatore Evangelista, Guilia Rinaldi, Francesca Perrone-Congedi, Gian Paolo Spinelli, Valeria Stati, Davide Caruso, Alessandra Prete, Silverio TomaoDepartment of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, ItalyAbstract: Management of metastatic colorectal cancer requires a multimodal approach and must be performed by an experienced, multidisciplinary expert team. The optimal choice of the individual treatment modality, according to disease localization and extent, tumor biology, and patient clinical characteristics, will be one that can maintain quality of life and long-term survival, and even cure selected patients. This review is an overview of the different therapeutic approaches available in metastatic colorectal cancer, for the purpose of defining personalized therapeutic algorithms according to tumor biology and patient clinical features.Keywords: metastatic colorectal cancer, patient clinical features, tumor biology, multidisciplinary approach

  12. The harmonious relationship between faith and science from the perspective of some great saints: A brief comment.

    Science.gov (United States)

    Cortés, Manuel E; Del Río, Juan Pablo; Vigil, Pilar

    2015-02-01

    The objective of this editorial is to show that a harmonious relationship between science and faith is possible, as exemplified by great saints of the Catholic Church. It begins with the definitions of science and faith, followed by an explanation of the apparent conflict between them. A few saints that constitute an example that a fruitful relationship between these two seemingly opposed realities has been possible are Saint Albert the Great, Saint John of the Cross, Saint Giuseppe Moscati, and Saint Edith Stein, among others, and this editorial highlights their deep contributions to the dialogue between faith and reason. This editorial ends with a brief discussion on whether it is possible to be both a scientist and a man of faith.

  13. The Introduction for the IEC /TC 38'2001 plenary meeting%2001年IEC/TC38沈阳会议情况介绍

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ IEC、TC 38于2001年5月28-30日在中国沈阳举行了会议(28日为工作组会议),受国家质量检验监督检疫总局委托,本次会议由沈阳变压器研究所负责承办.参加会议的共有14个国家(包括中国)35名代表,详见代表名单.会议主席是意大利的Giuseppe Zingales,秘书由意大利的FlavvioMauri代替FililppoFrugoni(Fililppo Frugoni因病未能参加),IEC中央办公室的Alan Harmer和中国电器工业协会标准部的方晓燕主任也参加了会议.

  14. 不断革新,让驾乘更安全、环保与舒适

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    在2007上海车展上,来自意大利的知名零部件供应玛涅蒂·马瑞利集团(Magneti Marelli向观众展示了旗下动力、悬挂、电子、排放及车灯等系统的产品与技术。马瑞利动力系统总裁(全球)Piero Toselli先生、车身电子系统总裁(全球)Giuseppe Rosso先生和马瑞利中国区总裁Luca Biagini先生共同出现在媒体见面会上,向大家介绍了有关马瑞利集团的业务情况。

  15. Professor Camillo Negro's Neuropathological Films.

    Science.gov (United States)

    Chiò, Adriano; Gianetto, Claudia; Dagna, Stella

    2016-01-01

    Camillo Negro, Professor in Neurology at the University of Torino, was a pioneer of scientific film. From 1906 to 1908, with the help of his assistant Giuseppe Roasenda and in collaboration with Roberto Omegna, one of the most experienced cinematographers in Italy, he filmed some of his patients for scientific and educational purposes. During the war years, he continued his scientific film project at the Military Hospital in Torino, filming shell-shocked soldiers. In autumn 2011, the Museo Nazionale del Cinema, in partnership with the Faculty of Neurosciences of the University of Torino, presented a new critical edition of the neuropathological films directed by Negro. The Museum's collection also includes 16 mm footage probably filmed in 1930 by Doctor Fedele Negro, Camillo's son. One of these films is devoted to celebrating the effects of the so-called "Bulgarian cure" on Parkinson's disease.

  16. The harmonious relationship between faith and science from the perspective of some great saints: A brief comment

    Science.gov (United States)

    Cortés, Manuel E.; del Río, Juan Pablo; Vigil, Pilar

    2015-01-01

    The objective of this editorial is to show that a harmonious relationship between science and faith is possible, as exemplified by great saints of the Catholic Church. It begins with the definitions of science and faith, followed by an explanation of the apparent conflict between them. A few saints that constitute an example that a fruitful relationship between these two seemingly opposed realities has been possible are Saint Albert the Great, Saint John of the Cross, Saint Giuseppe Moscati, and Saint Edith Stein, among others, and this editorial highlights their deep contributions to the dialogue between faith and reason. This editorial ends with a brief discussion on whether it is possible to be both a scientist and a man of faith. PMID:25698837

  17. If You Don't Have a Good Laboratory, Find a Good Volcano: Mount Vesuvius as a Natural Chemical Laboratory in Eighteenth-Century Italy.

    Science.gov (United States)

    Guerra, Corinna

    2015-08-01

    This essay that examines the role of the volcano as a chemical site in the late eighteenth century, as the "new chemistry" spread throughout the southern Italian Kingdom of Naples, resulting in lively debates. In Naples itself, these scientific debates were not confined to academies, courts, and urban spaces. In the absence of well-equipped chemical laboratories, Neapolitan scholars also carried out research on chemistry on the slopes of Mount Vesuvius, a natural site that furnished them with all the tools and substances necessary for practising chemistry. By examining various Neapolitan publications on Vesuvius and the chemical reactions and products associated with its periodic eruptions, I argue that the volcano's presence contributed to a distinctive, local approach to chemical theory and practice. Several case studies examine the ways in which proximity to Vesuvius was exploited by Neapolitan scholars as they engaged with the new chemistry, including Giuseppe Vairo, Michele Ferrara, Francesco Semmola, and Emanuele Scotti.

  18. Scuba club

    CERN Multimedia

    Scuba club

    2015-01-01

    The CERN Scuba club will be offering a free trail scuba dive sessions for anyone interested in trying this passionate activity. You don't have to be a daredevil or a great swimmer. Anyone curious to try can have a go. So don't miss the golden opportunity to discover a whole new fascinating world, taking your first breaths underwater! Two separate sessions will be help on Wednesday 7th October and Wednesday 14th October, both starting at 19:00 at the Varembe Swimming pool, 46 Avenue Giuseppe-Motta, 1202 Geneva. To sign up send an email to: subaqua@cern.ch (please indicate which date you wish to attend. You may only attend one). This event is open to adults and young people 14+. Minors must be accompanied by a parent. More information will soon be made available at the club website https://subaqua.web.cern.ch/subaqua/

  19. Scuba club

    CERN Multimedia

    Scuba club

    2014-01-01

    The CERN Scuba club will be offering a free trail scuba dive sessions for anyone interested in trying this passionate activity. You don't have to be a daredevil or a great swimmer. Anyone curious to try can have a go. So don't miss the golden opportunity to discover a whole new fascinating world, taking your first breaths underwater! Two separate sessions will be help on Wednesday 24th September and Wednesday 1st October, both starting at 19:00 at the Varembe Swimming pool, 46 Avenue Giuseppe-Motta, 1202 Geneva. To sign up send an email to: subaqua@cern.ch (please indicate which date you wish to attend. You may only attend one). This event is open to adults and young people 14+. Minors must be accompanied by a parent. More information will soon be made available at the club website https://subaqua.web.cern.ch/subaqua/.

  20. In the heart of CERN in 1967

    CERN Multimedia

    Public Information Office at CERN & Guido Franco

    1967-01-01

    A round trip through CERN, where you meet Lew Kowarski, Francis Perrin, Oppenheimer, Niels Bohr; where you listen to Emilio Picasso, Francis Farley, John Bailey, Bernard Gregory, Leon Van Hove, Giuseppe Cocconi; where you share discussion between theorists Jean Iliopoulos, Daniele Amati, John Bell and Jacques Prentki .......Begins with council session, announce of filming. Explanation of council and reasons for creating CERN, history of CERN. Explanation of what happens at CERN. (Anthoine to visitors) Lew Kowarsky. Picasso's explanation of G-2 experiment, a classic - "is very easy really" with Guido Franco as the person who is not a physicist who does not understand the explanation. 2 meter bubble chamber. Scanning. Computer centre. * Theorists at a blackboard. Cocconi giving conference and film portrait "when I was younger research was less expensive....one can't run counter to evolution. (with jazz background). Cafeteria. Johnsen explaining why building ISR. Gregory "highest energies and biggest laboratorie...

  1. Le faux, source intentionnelle d’erreurs : le cas des contrefaçons de peintures antiques

    OpenAIRE

    Burlot, Delphine

    2011-01-01

    Les faux ne sont réalisés que s’il existe une demande pour le type d’œuvres qu’ils cherchent à imiter. Ainsi, les contrefaçons de peintures murales antiques n’apparaissent qu’à la fin du xviie siècle, à Rome, alors que l’on commence à collectionner les fragments peints. Au milieu du xviiie siècle, plusieurs amateurs d’antiquités s’y sont laissé prendre, comme Mead, Caylus et Winckelmann. Le faussaire qui les a trompés, Giuseppe Guerra, a réalisé ses œuvres à partir de fragments d’enduits anti...

  2. Rivas y Verdi: Las trampas de la libertad en La fuerza del sino y La forza del destino

    Directory of Open Access Journals (Sweden)

    Egido, Aurora

    2012-06-01

    Full Text Available A comparative analysis between Duque de Rivas’Don Álvaro o la fuerza del sino and La forza del destino by Giuseppe Verdi shows, even in their very titles, the close relationship between Spain and Italy since the days of the Golden Age. Both works posit the old theological problem of compatibility between predestination and free will, while adding new social and political insights into social and racial differences and highlighting the narrowness of the code of honour. Otherwise, as far as the admixture of genres or the treatment of costumbrismo and nationalism are concerned, the difference between both works increases in the second version of Verdi´s opera, in which the alteration of the denouement wipes out the tragical dimension of the spanish play.Un análisis comparativo entre Don Álvaro o la fuerza del sino del duque de Rivas y La forza del destino de Giuseppe Verdi demuestra, ya desde sus títulos, un viaje de y vuelta entre España e Italia que tiene como fondo la literatura del Siglo de Oro. Ambas obras plantean el viejo problema entre providencia y libertad, añadiendo nuevos relieves sociales y políticos sobre las diferencias de clase y raza que ponen en evidencia las estrecheces del código del honor. Las diferencias entre ambas —más allá de la mezcla genérica, el tratamiento costumbrista y el nacionalismo— se acentúan en la segunda versión de la ópera verdiana, que, al cambiar el desenlace, destruyó el sentido trágico del drama español.

  3. Effects of combined training vs aerobic training on cognitive functions in COPD: a randomized controlled trial

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    Aquino G

    2016-04-01

    Full Text Available Giovanna Aquino,1 Enzo Iuliano,1 Alessandra di Cagno,2 Angela Vardaro,3 Giovanni Fiorilli,1 Stefano Moffa,1 Alfonso Di Costanzo,1 Giuseppe De Simone,3 Giuseppe Calcagno1 1Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, 2Department of Health Science, University ForoItalico, Rome, 3“Villa Margherita”, Benevento, Italy Aim: The aim of this study was to investigate the effects of high-intensity aerobic training (AT and high-intensity aerobic training combined with resistance training (ie, combined training [CT] on cognitive function in patients with COPD. Methods: Twenty-eight Caucasian male patients (68.35±9.64 years; mean ± SD with COPD were recruited and randomized into two groups, AT and CT. Both groups performed physical reconditioning for 4 weeks, with a frequency of five training sessions per week. The CT group completed two daily sessions of 30 minutes: one aerobic session and one strength session, respectively; The AT group performed two 30-minute aerobic endurance exercise sessions on treadmill. Physical and cognitive function tests were performed before and after the training intervention performances. Results: Exercise training improved the following cognitive functions: long-term memory, verbal fluency, attentional capacity, apraxia, and reasoning skills (P<0.01. Moreover, the improvements in the CT group were significantly greater than those in the AT group in long-term memory, apraxia, and reasoning skills (P<0.05. Conclusion: CT may be a possible strategy to prevent cognitive decline and associated comorbidities in male patients with COPD. Keywords: physical training, cognition, resistance training, rehabilitation, respiratory disease

  4. Comparison of facial expression in patients with obsessive-compulsive disorder and schizophrenia using the Facial Action Coding System: a preliminary study

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    Bersani G

    2012-12-01

    Full Text Available Giuseppe Bersani,1 Francesco Saverio Bersani,1,2 Giuseppe Valeriani,1 Maddalena Robiony,1 Annalisa Anastasia,1 Chiara Colletti,1,3 Damien Liberati,1 Enrico Capra,2 Adele Quartini,1 Elisa Polli11Department of Medical-Surgical Sciences and Biotechnologies, 2Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, 3Department of Neuroscience and Behaviour, Section of Psychiatry, Federico II University of Naples, Naples, ItalyBackground: Research shows that impairment in the expression and recognition of emotion exists in multiple psychiatric disorders. The objective of the current study was to evaluate the way that patients with schizophrenia and those with obsessive-compulsive disorder experience and display emotions in relation to specific emotional stimuli using the Facial Action Coding System (FACS.Methods: Thirty individuals participated in the study, comprising 10 patients with schizophrenia, 10 with obsessive-compulsive disorder, and 10 healthy controls. All participants underwent clinical sessions to evaluate their symptoms and watched emotion-eliciting video clips while facial activity was videotaped. Congruent/incongruent feeling of emotions and facial expression in reaction to emotions were evaluated.Results: Patients with schizophrenia and obsessive-compulsive disorder presented similarly incongruent emotive feelings and facial expressions (significantly worse than healthy participants. Correlations between the severity of psychopathological condition (in particular the severity of affective flattening and impairment in recognition and expression of emotions were found.Discussion: Patients with obsessive-compulsive disorder and schizophrenia seem to present a similarly relevant impairment in both experiencing and displaying of emotions; this impairment may be seen as a chronic consequence of the same neurodevelopmental origin of the two diseases. Mimic expression could be seen as a behavioral indicator of affective

  5. Facial expression in patients with bipolar disorder and schizophrenia in response to emotional stimuli: a partially shared cognitive and social deficit of the two disorders

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    Bersani G

    2013-08-01

    Full Text Available Giuseppe Bersani,1 Elisa Polli,1 Giuseppe Valeriani,1 Daiana Zullo,1 Claudia Melcore,1 Enrico Capra,2 Adele Quartini,1 Pietropaolo Marino,1 Amedeo Minichino,2 Laura Bernabei,2 Maddalena Robiony,1 Francesco Saverio Bersani,1,2 Damien Liberati1 1Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy; 2Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy Introduction: It has recently been highlighted that patients affected by schizophrenia (SCZ and those affected by bipolar disorder (BD undergo gradual chronic worsening of cognitive and social functioning. The objective of the current study was to evaluate and compare (using the Facial Action Coding System [FACS] the way by which patients with the two disorders experience and display emotions in relation to specific emotional stimuli. Materials and methods: Forty-five individuals participated in the study: 15 SCZ patients, 15 BD patients, and 15 healthy controls. All participants watched emotion-eliciting video clips while their facial activity was videotaped. The congruent/incongruent feeling of emotions and the facial expression in reaction to emotions were evaluated. Results: SCZ and BD patients presented similar incongruent emotive feelings and facial expressions (significantly worse than healthy participants; SCZ patients expressed the emotion of disgust significantly less appropriately than BD patients. Discussion: BD and SCZ patients seem to present a similar relevant impairment in both experiencing and displaying emotions; this impairment may be seen as a behavioral indicator of the deficit of social cognition present in both the disorders. As the disgust emotion is mainly elaborated in the insular cortex, the incongruent expression of disgust of SCZ patients can be interpreted as a further evidence of a functional deficit of the insular cortex in this disease. Specific remediation training could be used to improve

  6. Single nucleotide polymorphisms and unacceptable late toxicity in breast cancer adjuvant radiotherapy: a case report

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    Lazzari G

    2017-05-01

    Full Text Available Grazia Lazzari,1 Maria Iole Natalicchio,2 Angela Terlizzi,3 Francesco Perri,4 Giovanni Silvano1 1Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 2Molecular Biology Laboratory, Pathological Anatomy Department, Ospedali Riuniti, Foggia, 3Medical Physic Unit, San Giuseppe Moscati Hospital, 4Medical Oncology Unit, Presidio Ospedaliero Centrale - Santissima Annunziata, Taranto, Italy Background: There has recently been a strong interest in the inter-individual variation in normal tissue and tumor response to radiotherapy (RT, because tissue radiosensitivity seems to be under genetic control. Evidence is accumulating on the role of polymorphic genetic variants, such as single nucleotide polymorphisms (SNPs that could influence normal tissue response after radiation. The most studied SNPs include those in genes involved in DNA repair (single- and double-strand breaks, and base excision and those active in the response to oxidative stress.Case report: We present the case report of a 60-year-old woman with early breast cancer who underwent adjuvant hormone therapy and conventional radiotherapy, and subsequently developed unacceptable cosmetic toxicities of the irradiated breast requiring a genetic test of genes involved in DNA repair mechanisms. The patient was found to be heterozygous for G28152A (T/C and C18067T (A/G mutations in X-ray repair cross-complementing group 1 (XRCC1 and 3 (XRCC3, respectively, homozygous for A313G (G/G mutation in glutathione S transferase Pi 1 (GSTP1, and wild-type for A4541G (A/A in XRCC3 and G135C (G/G in RAD51 recombinase.Conclusion: The role of SNPs should be taken into account when a severe phenomenon appears in normal tissues after radiation treatment, because understanding the molecular basis of individual radiosensitivity may be useful for identifying moderately or extremely radiosensitive patients who may need tailored therapeutic strategies. Keywords: radiosensitivity, SNPs, fibrosis, DNA repair

  7. Depression, body mass index, and chronic obstructive pulmonary disease – a holistic approach

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    Catalfo G

    2016-02-01

    Full Text Available Giuseppe Catalfo,1 Luciana Crea,1 Tiziana Lo Castro,1 Francesca Magnano San Lio,1 Giuseppe Minutolo,1 Gherardo Siscaro,2 Noemi Vaccino,1 Nunzio Crimi,3 Eugenio Aguglia1 1Department of Psychiatry, Policlinico “G. Rodolico” University Hospital, University of Catania, Catania, Italy; 2Operative Unit Neurorehabilitation, IRCCS Fondazione Salvatore Maugeri, Sciacca, Italy; 3Department of Pneumology, Policlinico “G. Rodolico” University Hospital, University of Catania, Catania, Italy Background: Several clinical studies suggest common underlying pathogenetic mechanisms of COPD and depressive/anxiety disorders. We aim to evaluate psychopathological and physical effects of aerobic exercise, proposed in the context of pulmonary rehabilitation, in a sample of COPD patients, through the correlation of some psychopathological variables and physical/pneumological parameters. Methods: Fifty-two consecutive subjects were enrolled. At baseline, the sample was divided into two subgroups consisting of 38 depression-positive and 14 depression-negative subjects according to the Hamilton Depression Rating Scale (HAM-D. After the rehabilitation treatment, we compared psychometric and physical examinations between the two groups. Results: The differences after the rehabilitation program in all assessed parameters demonstrated a significant improvement in psychiatric and pneumological conditions. The reduction of BMI was significantly correlated with fat mass but only in the depression-positive patients. Conclusion: Our results suggest that pulmonary rehabilitation improves depressive and anxiety symptoms in COPD. This improvement is significantly related to the reduction of fat mass and BMI only in depressed COPD patients, in whom these parameters were related at baseline. These findings suggest that depressed COPD patients could benefit from a rehabilitation program in the context of a multidisciplinary approach. Keywords: COPD, depression, aerobic exercise

  8. Himnos nacionales

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    Marco LUCATO

    2009-11-01

    Full Text Available RESUMEN: En este artículo se tratará de reflejar la importancia que los himnos han tenido en todas las épocas y países, lo cual se manifiesta por la tendencia universal que siempre ha existido de asociar el propio himno a las aspiraciones y espíritu de todo un pueblo. Este método de trabajo nos puede servir como base para el estudio de la música folklórica de cualquier lugar del mundo, pretendiendo no sólo hacer un análisis comparativo de melodías , ritmos y danzas sino intentar ver más allá de las simples notas musicales para tratar de captar los siglos de historia que se esconden detrás, así como los mensajes ocultos que hablan de dolor, amor, guerra y esperanza. El artículo se organiza en tres partes:1 Análisis histórico comparativo2 Análisis musical comparativo3 «Inno delle Nazioni» de Giuseppe Verdi.SUMMARY: We'll try show in this article the importance that hymns have had in all times all along the countries. This is clearly seen through the universal tendency that has always existed to associate the hymn itself to the hopes and spirit of a people. This working method can be the right one for the study of folk music in any country, trying not only to analyse the melodies, rhythms and dancings but also to go beyond the musical tones to understand the centuries of history that can be found underneath, as well as the messages that tell us of pain, love, war and hope. The article is organized in three parts:1 Comparative historical analysis2 Comparative musical analysis3 «Inno delle Nazioni» by Giuseppe Verdi.

  9. Antonio Mollari fra Canova e Valadier / Antonio Mollari between Canova and Valadier

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    Elisa Debenedetti

    2014-04-01

    Full Text Available Non è difficile inserire Antonio Mollari in un contesto europeo. Ad Antonio Canova lo lega una prima, importantissima lettera del 4 maggio 1807 nella quale, in seguito ad un invito trasmessogli dallo scultore, ma di cui è responsabile Filippo III Colonna, enumera tutte le sue opere; la seconda risale al 25 febbraio 1809. Dalla prima missiva si riescono a stabilire numerosi contatti con Giuseppe Valadier: a Corridonia (Collegiata dei Santi Pietro, Paolo e Donato; Ospedale e Chiesa di San Salvatore e a Macerata (Palazzo Conti già Ugolini. Tanto da giungere a considerare Mollari come il continuatore del Valadier nei cantieri marchigiani, dove la presenza del Maestro si manifesta come una sovrapposizione di motivi francesizzanti a soluzioni palladiane: componenti entrambe presenti nel Palazzo Tomassini a Corridonia, ricondotto al Maceratese. Fra l’altro le pagine di due Taccuini valadieriani, certo a lui note, si possono considerare a metà strada fra l’esercizio tipologico ed il modello. It’s not difficult to insert Antonio Mollari into a European context. A first very important letter, dated May 4th 1807, links him to Antonio Canova whereby, after inviting him, by wish of Phillip Colonna III , he then makes a list of all his works of art; the second is dated February 25th 1809. Various contacts with Giuseppe Valadier can be established from the first letter: in Corridonia (Saints Peter, Paul and Donato Collegiate church; St. Saviour’s Hospital and Church and in Macerata (Conti Palace ex Ugolini. So much so as to regard Mollari as Valadier’s continuator in the Marche construction sites, where the Maestro’s presence is expressed like a superimposition of Frenchified motives for Palladian solutions: both components being present in the Tomassini Palace in Corridonia, which can be traced back to Mollari. Moreover the pages of two Valdier Notebooks, which he must have known about, can be considered half way between a typological exercise

  10. Theory on single molecule_photon cryocooler

    Institute of Scientific and Technical Information of China (English)

    QIN; Weiping

    2001-01-01

    [1]Pringsheim, P., Zwei Bemerkungen über den Unterschied von Lumineszenz_ und Temperaturstrahlung, Z. Phys., 929, 57(8): 739.[2]Djeu, N., Whitney, W. T., Laser cooling by spontaneous anti_Stokes scattering, Phys. Rev. Lett., 98, 46(4): 236.[3]Epstein, I., Buchwald, M. I., Edwards, B. C. et al., Observation of laser_induced fluorescent cooling of a solid, Nature, 995, 377(2): 500.[4]Clark, J. L., Rumbles, G., Laser cooling in the condensed phase by frequency up_conversion, Phys. Rev. Lett., 996, 76(2): 2037.[5]Mungan, C. E., Buchwald, M. I., Edwards, B. C. et al., Laser cooling of a solid by 6 K starting from room temperature, Phys. Rev. Lett., 997, 78(6): 030.[6]Luo, X., Eisaman, M. D., Gosnell, T. R., Laser cooling of a solid by 2K starting from room temperature, Opt. Lett., 998, 23(8): 639.[7]Gosnell, T. R., Laser cooling of a solid by 2K starting from room temperature, Optics Let., 999, 24(5): 04.[8]Epstein, I., Buchwald, M. I., Edwards, B. C. et al., The Los Alamos solid_state optical refrigerator, Cryocoolers 9, New York: Plenum, 997, 68—686.[9]Qin Weiping, Zhang Jiahua, Huang Shihua, Laser_induced anti_Stokes fluorescent cooling, Physics (in Chinese), 998, 27(6): 323.[10]Christiansen, W. H., Hertzberg, A., Gasdynamic lasers and photon machines, Proc. IEEE, 973, 6(8): 060.[11]Qin Weiping, Zhang Jiahua, Huang Shihua, Study on the fluorescent cooling by energy transfer within in homogenous line shape in solids, Acta Physica Sinica (in Chinese), 998, 47(8): 397.[12]Qin Weiping, Zhang Jiahua, Chen Baojiu et al., Two basic mechanism in anti_Stokes fluorescent cooling of solids, Chinese Journal of Luminescence, 999, 20(2): 26.[13]Fournier, J. T., Bartram, R. H., Inhomogeneous broadening of the optical spectra of Yb3+in phosphate glass, J. Phys. Chem. Solids, 970, 3(2): 265.

  11. Mundo Braz. El devenir-mundo de Brasil y el devenir-Brasil del mundo

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    Rodrigo Martínez Reinoso

    2015-02-01

    Full Text Available Reseña: Mundo Braz. El devenir-mundo de Brasil y el devenir-Brasil del mundo   MundoBraz. El devenir-mundo de Brasil y el devenir-Brasil del mundo es el título que lleva la obra del filósofo italiano radicado en Brasil Giuseppe Cocco. Fue publicada originalmente en portugués (Río de Janeiro, 2009 y editada en español por la Editorial Traficantes de Sueños tres años después (Madrid, 2012. Sus principales aportaciones se relacionan con el análisis político y social de nuestra realidad contemporánea bajo una línea de investigación neo-marxista que ha dado origen a dos emblemáticas publicaciones, las cuales son en rigor los antecedentes inmediatos del espíritu crítico, transdisciplinario y altermundista que caracteriza a MundoBraz. [1] Cocco, Giuseppe (2012: MundoBraz. El devenir-mundo de Brasil y el devenir-Brasil del mundo. Traficantes de Sueños, Madrid. Giuseppe Cocco se formó en Italia y Francia y fue activista político en los años 70 de Autonomía Obrera. Es Licenciado en Ciencias Políticas (Università degli Studi di Padova, 1981, Licenciado en Ciencias Políticas (Université de Paris VIII, 1984, Master of Science Technologie et Société (Conservatoire National des Arts et Métiers, 1988, MA en Historia Social (Universidad de París I (Panthéon-Sorbonne, 1986 y Doctor en Historia Social (Universidad Paris I Panthéon-Sorbonne, 1993. Ejerce como profesor de la Universidad Federal de Río de Janeiro y es editor de diversas revistas de perfil neomarxista y altermundista: Global Brasil, Common Place y Multitudes. Un modo de resumir el valor de esta bella y asombrosa obra quizás consista en decir que cumple a cabalidad con el sentido de lo que Deleuze y Guattari han denominado como una política menor. La cual, paradójicamente, si bien derriba una serie de dogmas del liberalismo y del marxismo, tal mirada no se queda en un diagnóstico fatídico y determinista (como sería el economicismo que acusa al neoliberalismo de

  12. ROMÂNI ŞI MAGHIARI ÎNTR-O DISPUTĂ POLITICĂ REFERITOARE LA IDEEA DE NAŢIUNE: DUMITRU BRĂTIANU ŞI DANIEL IRANYI ÎN ZIARUL „LA PRESS” (1851

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    Remus TANASĂ

    2016-12-01

    Full Text Available În iunie 1851, Dumitru Brătianu s-a alăturat Comitetului Democratic European dela Londra, condus de Giuseppe Mazzini. Scopul românilor a fost de a lua parte, alături de alte naţionalităţi, la revoluţia europeană împotriva autorităţii tradiţionale a guvernelor dinastice, în special împotriva imperiilor Habsburgic şi Ţarist, şi în favoarea autodeterminării naţionale şi instituţionale.În acest context, polemica cu exilul maghiar a fost inevitabilă, din moment ce liderii Revoluţiei maghiare din 1848 se aflau tot în exil şi la fel urmăreau autodeterminarea naţională. O dispută referitoare la ideea de naţiune a avut loc între Dumitru Brătianu şi Daniel Iranyi, fost secretar al Comitetului Salvării Publice dela Pesta, publicată în paginile ziarului francez „La Presse”.ROMANIANS AND HUNGARIANS IN A POLITICAL DISPUTE OVER THE IDEA OF NATION: DUMITRU BRĂTIANU AND DANIEL IRANYI ÎN „LA PRESS” NEWSPAPER (1851In June 1851, Dumitru Brătianu had joined Giuseppe Mazzini’s European Democratic Committee of London. The purpose of the Romanians was to take part together with the other nationalities at the European revolution against the authority traditionally exercised by the dynastic governments, especially against the Habsburg and the Tsarist Empires, in favor of a national and institutional self-determination.In this context, a polemic with the Hungarian exile was inevitable, since the leaders of the Hungarian Revolution of 1848 were also in exile and were too aiming for national self-determination. A dispute over the idea of nation took place in the pages of the French newspaper „La Presse”, between Dumitru Brătianu and Daniel Iranyi, the former secretary of the Public Salvation Committee of Pest.

  13. Eugenistas, pero con prudencia

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    Pogliano, Claudio

    1999-12-01

    Full Text Available Thinking that one could not describe eugenics like a unique movement, since numerous bound varians took place related to the geographical and cultural context, this article tries to demostrate the peculiarity of the Italian case. If already in 1889 Giuseppe Sergi wanted that the artificial selection take it to end what should make the natural, avoiding the risk of the so called «degeneration», only in the face of the First World War seems to grow the alarm for the decadent quality of the population, finding a more and more wide echo. In 1919 the Siges was born (Società italiana de genetica ed eugenica shocked under the impression of the difusse fear about the butcher the war had caused. From there from now on fastens a «nazional» direction closely related to the traditional thought and also with the new political temper. A «moderate» direction, Fascist, Catholic, that was built in consonance with the pronatalism of the regime and in rough polemic with the presumed Anglo-Saxon eugenics aberration.

    Partiendo de la base de que no se puede describir la eugénica como un movimiento unitario, ya que se produjeron numerosas variantes ligadas al contexto geográfico y cultural, este artículo intenta demostrar la peculiaridad del caso italiano. Si ya en 1889 Giuseppe Sergi deseaba que la selección artificial llevase a cabo lo que debía de hacer la natural, evitando así el riesgo de la «degeneración », sólo ante la Primera Guerra Mundial parece crecer la alarma por la decadente calidad de la población, encontrando un eco cada vez más amplio. En 1919 nació la Sige (Società italiana de genetica ed eugenica bajo la impresión del difuso temor que la carnicería bélica había provocado. De ahí en adelante prende rápidamente una dirección «nazional» que se imbrica tanto con una tradición del pensamiento como con el nuevo temple político. Una dirección «moderada» fascista, católica, que se construyó en consonancia con el

  14. A Comparative Study of the Soprano Aria in Verdi's Opera——A case study of "E'strano! E'strano!" and "Pace,Pace,Mio Dio"%威尔第歌剧女高音咏叹调的比较——以《为什么他的话使我这样感动》与《安宁,安宁》为例

    Institute of Scientific and Technical Information of China (English)

    罗仙泗

    2011-01-01

    朱塞佩.威尔第(Giuseppe Verdi,1813~1901)是西方音乐史上伟大的歌剧作曲家,除去一些宗教合唱、歌曲和一首弦乐四重奏外,他的一生始终专注于歌剧。他旺盛的创作力持续了将近50年。其中歌剧《茶花女》(la Traviata,1853),《命运之力》(la Forzadel Destino,1862)是他中期的代表作。本文通过对剧作者、创作背景、剧情方面的把握,分别对剧本中的人物性格和演唱风格进行探讨,将歌剧《茶花女》里著名的女高音咏叹调《为什么他的话使我这样感动》与歌剧《命运之力》里的咏叹调《安宁,安宁》进行了一番音乐比较分析,以其从中了解威尔第歌剧的创作风格。%Giuseppe Verdi,one of the greatest opera composers in the western music history,devoted almost all of his life to opera composition,and his energetic composing work lasted for nearly 50 years,with "la Traviata"(1853) and "la Forza del Destino"(1862) as representative works in the middle of his opera life.Based on the understanding of the composer,the creation background,and the story of the operas,this paper makes a comparative study between "E'strano! E'strano!",a famous soprano aria from "la Traviata",and "Pace,Pace,Mio Dio",a piece of aria from "la Forza del Destino",analyzing the character personality and singing style in both pieces,so at to study the creative style of Verdi's opera composition.

  15. The embalming, the scientific method and the paleopathology: the case of Gaetano Arrighi (1836).

    Science.gov (United States)

    Ciranni, Rosalba; Caramella, Davide; Nenci, Riccardo; Fornaciari, Gino

    2005-01-01

    Since the most ancient times the problem of the artificial preservation of dead bodies has been an important object of study. In ancient and classic times the reasons leading to this practice were essentially of a religious and esoteric type, but in the modern age, following the development of medical and biological studies, embalming has assumed a more practical trend which is both medicine and scientific. The discovery of blood circulation has marked the scientific method which, in its various forms, has circulated all over Europe bringing fame to eminent anatomists such as Federico Ruysch (1638-1731), William (1718-1783) and John Hunter (1728-1793), Jean Nicolas Gannal (1791-1852), Giuseppe Tranchina, Laskowky and Brosch, who affirmed the embalming by endoarterial injection of conservation fluids making evisceration useless and obsolete. The advent of formalin and the introduction of new surgical and autoptic methods have made this practice gradually fall into disuse. For this reason, the mummy found in Leghorn (Tuscany, Central Italy) is of particular importance since was obtained applying the intravascular injection following the method, described by the Italian medical Giuseppe Tranchina in 1835. The mummified body belongs to Gaetano Arrighi, a prisoner in the Leghorn fortress. He was born in Arezzo in 1789 and died on March 1836 at the age of 47 in the Civil Hospital of Leghorn following pleurisy, as results in an annexed document. The day after his death Dr. Raimondo Barsanti from Pisa and Superintendent at the Leghorn hospital made up the Tranchina's method, which consisted in the injection of an arsencial -mercury solution inside of the blood vessels, giving rigidity and dark red color to the dead body. The excellent outcome of the intervention has made it possible, more than 160 years later, to study not only the method by which Arrighi's body was embalmed but also to perform a careful paleopathological imaging study by traditional X-rays and by Computer

  16. «Arte al servizio di un’idea». Il ruolo dell’“Esposizione dell’Aeronautica italiana” (1934 nel dialogo tra arte, architettura, politica e pubblico / «Arte al servizio di un’idea» (Art at an idea’s service. The role of the “Esposizione dell’Aeronautica italiana” (1934 in the dialogue between art, architecture, politics and public

    Directory of Open Access Journals (Sweden)

    Orietta Lanzarini

    2016-12-01

    Full Text Available Nel panorama delle mostre di regime, l’”Esposizione dell’Aeronautica italiana”, allestita a Milano nel 1934, occupa un posto di grande rilievo politico e artistico. Il tema prescelto, particolarmente caro a Mussolini e di sicura presa sul pubblico, consente di ripercorrere la storia del volo, dagli studi di Leonardo ai primi arditi che tentarono di levarsi dal suolo, fino alle imprese aviatorie sostenute dal regime, che culminano con la crociera aerea del Decennale, dall’Italia agli Stati Uniti, guidata da Italo Balbo nel 1933. Per gli architetti chiamati ad allestire la cosiddetta “Mostra azzurra”, coordinati da Giuseppe Pagano, si tratta di un’occasione altrettanto preziosa per promuovere l’architettura moderna e candidarla come «arte di stato». Questa loro aspirazione verrà presto disattesa, ma la ricerca artistica messa a punto per la mostra milanese, rimasta latente per alcuni anni, rinascerà nel dopoguerra, dando origine a una stagione straordinaria di allestimenti di mostre e di musei. In the panorama of exhibitions of the ruling party, the “Esposizione dell’Aeronautica italiana”, arranged at Milan in 1934, occupies a position of great political and artistic importance. The theme that had been selected – one particularly close to Mussolini’s heart – provided the opportunity to survey the history of flight from the studies of Leonardo to the daring aviators who tried to lift-off from the ground, up to the aerial enterprises undertaken by the governing party which culminated with the aerial cruise of the Decennale from Italy to the United States lead by Italo Balbo in 1933. For the architects (co-ordinated by Giuseppe Pagano invited to organize the so-called “Mostra azzurra” (“Deep Blue Exhibition”, this was a precious opportunity to promote contemporary architecture and to present it as «The Art of the State». Their aspirations were soon ignored, but the artistic endeavors concentrated in the

  17. Building a new Rasch-based self-report inventory of depression

    Directory of Open Access Journals (Sweden)

    Balsamo M

    2014-01-01

    Full Text Available Michela Balsamo,1 Giuseppe Giampaglia,2 Aristide Saggino11DiSPUTer, Department of Psychological Sciences, Humanities and Territory, “G d'Annunzio” University, Chieti-Pescara, Italy; 2Department of Economics and Statistics, “Federico-II” University, Naples, ItalyAbstract: This paper illustrates a sequential item development process to create a new self-report instrument of depression refined with Rasch analysis from a larger pool of potential diagnostic items elicited through a consensus approach by clinical experts according to the latest edition of the Diagnostic and Statistical Manual of Mental Disorders criteria for major depression. A 51-item pool was administered to a sample of 529 subjects (300 healthy community-dwelling adults and 229 psychiatric outpatients. Item selection resulted in a 21-item set, named the Teate Depression Inventory, with an excellent Person Separation Index and no evidence of bias due to an item–trait interaction (χ2=147.71; df =168; P=0.48. Additional support for the unidimensionality, local independence, appropriateness of the response format, and discrimination ability between clinical and nonclinical subjects was provided. No substantial differential item functioning by sex was observed. The Teate Depression Inventory shows considerable promise as a unidimensional tool for the screening of depression. Finally, advantages and disadvantages of this methodology will be discussed in terms of subsequent possible mathematical analyses, statistical tests, and implications for clinical investigations.Keywords: depression, scale development, self-report scales, Rasch analysis

  18. Dysonian SETI as a "Shortcut" to Detecting Habitable Planets

    Science.gov (United States)

    Wright, J. T.

    2016-12-01

    The search for habitable planets is ultimately motivated by the search for inhabited planets. On Earth, the most telling signature of life is that of humanity's technology. The Search for Extraterrestrial Intelligence (SETI) is thus the "ultimate" search for habitable planets.In 1960 two seminal papers in SETI were published, providing two visions for SETI. Giuseppe Cocconi and Philip Morrison's proposed detecting deliberate radio signals ("communication SETI"), while Freeman Dyson ("artifact SETI"), proposed detecting the inevitable effects of massive energy supplies and artifacts on their surroundings. While communication SETI has now had many career-long practitioners and major efforts, artifact SETI has, until recently, not been a vibrant field of study. The launch of the Kepler and WISE satellites have greatly renewed interest in the field, however, and the recent Breakthrough Listen Initiative has provided new motivation for finding good targets for communication SETI. I will discuss the progress of the Ĝ Search for Extraterrestrial Civilizations with Large Energy Supplies, including its justification and motivation, waste heat search strategy and first results, and the framework for a search for megastructures via transit light curves. The last of these led to the identification of KIC 8462852 (a.k.a. "Tabby's Star") as a candidate ETI host. This star, discovered by Boyajian and the Zooniverse Planet Hunters, exhibits several apparently unique and so-far unexplained photometric properties, and continues to confound natural explanation.

  19. On the lost portrait of Galileo by the Tuscan painter Santi di Tito

    Science.gov (United States)

    Molaro, Paolo

    2016-12-01

    We study here the first established image of Galileo from the engraving made by Giuseppe Calendi at the end of the eighteenth century after a lost portrait of 1601 by Santi di Tito. We show that the engraving cannot be an exact copy, as it contains several inaccuracies which are unlikely to have been present in the original painting. A recent claim of the discovery of the painting by Santi di Tito is examined, and some reasons for suspecting it to be a forgery are outlined. As an alternative, we suggest a connection between the engraving and a portrait attributed to Tintoretto (which is currently in the collection of the Padua Civic Museum). The engraving and the Padua painting look quite different but can be traced to a common origin if we assume that Calendi added the half body, copied the painting onto copper plate directly, and adjusted the shading slightly. In this way, several features and details of the engraving find a plausible explanation. Finally, we note a remarkable similarity between the Padua portrait and a figure included in a Cologne painting by Rubens dating to about 1602-1604, which was suggested by Huemer to be Galileo.

  20. Sobre una literatura europea

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    Giuseppe Mazzini

    2015-07-01

    Full Text Available "La necesidad de un cambio en la literatura de los pueblos es algo ya demasiado evidente, como para que sea necesario malgastar las palabras. Los acontecimientos, las instituciones, las nuevas creencias, los cambios de costumbres y las pasiones de distinta manera forjadas han creado la necesidad de una nueva literatura que exprese la situación y las opiniones de la civilización moderna; porque la literatura, cuando no se adentra en la vida civil y política de las naciones, es terreno abonado a nimiedades y solo sirve para reblandecer el espíritu". Con estas palabras arranca uno de los textos más célebres de Giuseppe Mazzini, D’una letteratura europea (1829. El texto, que ofrecemos en traducción de Juan Carlos Postigo, es el fruto ya maduro de la experiencia de un Mazzini lector claramente orientado a unir el carácter propio de la literatura a las vicisitudes civiles y políticas, profundizando en conceptos como el arte de la vida de una nación o la importancia de las instituciones en la cultura, superando con ello al mismo tiempo la reductiva óptica del patriotismo de corte romántico.

  1. Nation building and international solidarity: Some considerations about Balkans in Italian republican thinking in 19th century

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    Pasini Piero

    2015-01-01

    Full Text Available In this paper I want to review the thinking of some Italian republicans’ ideologists and patriots for what concerns the matter of National orders of Southern Slavs, with more attention to the Western Balkans. I argue that the Republicans had a particular conception of the National issues, different from the concepts of Nation and Nationality as intended by the Socialists, the Liberals and the Monarchists. Also I would like to underline a particular sensibility on the matter of the Nationality in Balkans by that Italian patriots subjected to the Austrian crown. Of course I will deal with the ideas of Giuseppe Mazzini, that has already been well studied by the Italian, Slav and International historiography, but also the ideas of Tommaseo, Italian from Dalmatia, republican but not on the same positions of Mazzini, of Attilio and Emilio Bandiera, Venetian patriots near to Mazzini’s thinking, but independent in actions and political practice. I will also give some elements about the vision of the International order of liberals, monarchists and, overall, not Austrian’s subjected. The study of those topics appears very current in this period of crisis of the state-nation concept and seems useful to reconsider concepts such as unity, integration and solidarity of Europe and between Nations.

  2. La Casa del Fascio di Como e le sue

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    Cristina Casero

    2010-01-01

    Full Text Available Giuseppe Terragni’s ‘Casa del Fascio’ in Como undoubtedly stands out as a masterpiece of Italian ‘Razionalismo’, though inflected according to the architect’s peculiar language. However, as rightly noted by Diane Ghirardo, a merely formal analysis of the building is not plausible. The underlying meaning and the very value of the ‘Casa del Fascio’ are fully perceivable only by taking into consideration the original project, without overlooking the opulent ‘decoration’ specifically intended as an integral part of the building. That includes Marcello Nizzoli’s photomechanical panels for the façade, built but never actually put in place, and Mario Radice’s works for the ‘Sala del Direttorio’ and the ‘Salone delle Adunate’, both destroyed in the immediate post-war; also worth mentioning are the decorative projects by the architect himself for the ‘Sala Federale’ and the room entitled to Gigi Maino. From such a perspective, the ‘Casa del Fascio’ appears under a renovated light, as a building of great functional value, but also as a very interesting communicational device.

  3. Meniscal tears

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    Nicola Maffulli

    2010-04-01

    Full Text Available Nicola Maffulli1, Umile Giuseppe Longo2, Stefano Campi2, Vincenzo Denaro21Centre for Sports and Exercise Medicine, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Mile End Hospital, London, England; 2Department of Orthopedic and Trauma Surgery, Campus Biomedico University, Via Alvaro del Portillo, Rome, ItalyAbstract: The menisci are two semilunar-shaped fibrocartilagenous structures, which are interposed between the femoral condyles and tibial plateaux. They have an important role in knee function. Long-term follow-up studies showed that virtually all meniscectomized knees develop arthritic changes with time. The meniscus has functions in load bearing, load transmission, shock absorption, joint stability, joint lubrication, and joint congruity. Because of these functions, meniscal tissue should be preserved whenever possible. A well-trained surgeon can safely rely on clinical examination for diagnosing meniscal injuries. History and clinical examination are at least as accurate as magnetic resonance imaging in the skilled orthopedic surgeon’s hand. When meniscal repair is not possible, partial resection of the meniscus is indicated. Meniscal repair has evolved from open to arthroscopic techniques, which include the inside-out and outside-in suture repairs and the all-inside techniques. Meniscal transplantation is generally accepted as a management alternative option for selected symptomatic patients with previous complete or near-complete meniscectomy.Keywords: meniscus, arthroscopy, meniscectomy, meniscal repair, sports

  4. Targeted treatments in advanced renal cell carcinoma: focus on axitinib

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    Verzoni E

    2014-03-01

    Full Text Available Elena Verzoni, Paolo Grassi, Isabella Testa, Roberto Iacovelli, Pamela Biondani, Enrico Garanzini , Filippo De Braud, Giuseppe ProcopioDepartment of Medical Oncology 1, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyAbstract: Antiangiogenesis options have evolved rapidly in the last few years, with an increasing number of agents currently approved by the US Food and Drug Administration and European Medicines Agency. Angiogenesis inhibitors have been shown to be very effective for the treatment of metastatic renal cancer cell. Axitinib is a third-generation inhibitor of vascular endothelial growth factor receptor and is currently being developed for the treatment of various malignancies. The pharmacokinetic properties of axitinib may have a selective therapeutic effect, with minimal adverse reactions and enhanced safety. In a large Phase III study of previously treated patients with metastatic renal cell carcinoma, axitinib achieved a longer progression-free survival than sorafenib with an acceptable safety profile and good quality of life. This review focuses on the pharmacology, pharmacokinetics, and clinical activity of axitinib in the current treatment of renal cell carcinoma. The role of axitinib in the adjuvant and/or neoadjuvant setting needs to be evaluated in further clinical trials.Keywords: axitinib, renal cell carcinoma, vascular endothelial growth factor receptor, angiogenesis

  5. Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling

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    Femminella GD

    2014-09-01

    Full Text Available Grazia Daniela Femminella,1 Vincenzo Barrese,2,3 Nicola Ferrara,1,4 Giuseppe Rengo4 1Department of Translational Medical Sciences, Federico II University, Naples, Italy; 2Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy; 3Division of Biomedical Sciences, St George’s University of London, London, UK; 4”Salvatore Maugeri” Foundation – IRCCS – Scientific Institute of Telese Terme, Telese Terme, Benevento, Italy Abstract: Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic differences. Pharmacogenomics is the study of genetic contributions to drug response variability in order to provide evidence for a tailored therapy in an individual patient. Several studies have investigated the pharmacogenomics of the adrenergic receptor system and its role in the context of the use of β-blockers in treating heart failure. In this review, we will focus on the most significant polymorphisms described in the literature involving adrenergic receptors and adrenergic receptor-related proteins, as well as genetic variations influencing β-blocker metabolism. Keywords: adrenergic system, polymorphisms, β-blockers, functional recovery

  6. Partial-thickness corneal tissue restoration after a chemical burn

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    Galan A

    2016-04-01

    Full Text Available Alessandro Galan, Anton Giulio Catania, Giuseppe Lo Giudice San Paolo Ophthalmic Center, San Antonio Hospital, Padova, Italy Purpose: We describe a case of full-thickness corneal restoration after an acute corneal burn with an acid agent. Methods: A 32-year-old male reported painful discomfort, redness, photophobia, and a decrease in visual acuity in the left eye after a unilateral burn with an acid agent. Slit-lamp examination revealed massive corneal melting involving necrotic sequestrum of the entire corneal surface. Surgical approach was carried out in order to preserve residual ocular tissues. Results: Extensive corneal–conjunctival layer curettage of the necrotic tissue was performed showing perfectly clear undamaged deep lamellar corneal layers. The patient underwent multilayered amniotic membrane transplantation and total capsular–conjunctival flap in order to preserve ocular tissue from further melting or corneal perforation. A complete and spontaneous “restitutio ad integrum” of the corneal layers was shown during the follow-up. The cornea was perfectly clear with restored normal anatomical architecture. Conclusion: In this case, a spontaneous full-thickness corneal tissue restoration occurred after an acute chemical burn. Studies about the mechanisms whereby different cells interact and replicate within the stroma may unveil the biology behind corneal regeneration and transparency. Keywords: amniotic membrane, chemical burn, corneal healing

  7. Individualización e Institucionalización: Notas sobre la filosofía jurídica de Gino Capozzi, a partir de "Forze, leggi e poteri"

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    Giovanni Marino

    2005-01-01

    Full Text Available Se expone el praxeologismo de la escuela fenomenológica institucionalista napolitana, en la obra “Forze, leggi e poteri” de Gino Capozzi, a la luz de la tradición iusfilosófica italiana. Las reflexiones que la filosofía napolitana encara tienen como centro al individuo y su hacer, un hacer que lo constituye e individualiza y un hacer que se institucionaliza: sociedad, derecho, Estado. Capozzi reconstruye la individualización como ek-stási del hacer, como constitución del individuo en la sociedad y emancipación de la soledad. Y esta individualización es confrontada con la experiencia jurídica analizada por Giuseppe Capograssi, es decir, del individuo con el querer profundo de su acción que crea el derecho y con el ordenamiento jurídico de Santi Romano, como conciencia superior, reflejo y unificación de las conciencias individuales. Una confrontación que enriquece las implicaciones profundas de sociedad, derecho y Estado y la lectura de Sociedad, derecho y poder como conciencia, objetividad y sistema.

  8. Long-term treatment of rheumatoid arthritis with adalimumab

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    Murdaca G

    2013-05-01

    Full Text Available Giuseppe Murdaca, Francesca Spanò, Francesco PuppoDepartment of Internal Medicine, Clinical Immunology Unit, University of Genoa, Genoa, ItalyAbstract: Rheumatoid arthritis (RA is a chronic inflammatory disease that is associated with joint damage and progressive disability, an increased risk of morbidity related to comorbid conditions and substantial socioeconomic costs. Tumor necrosis factor-alpha (TNF-α is a proinflammatory cytokine known to have a central role in the initial host response to infection and in the pathogenesis of various immune-mediated diseases, such as RA, ankylosing spondylitis, psoriasis and/or psoriatic arthritis, Crohn’s disease, and systemic lupus erythematosus. Five TNF-α inhibitors are available for the clinical use: infliximab; adalimumab; etanercept; golimumab; and certolizumab pegol. Infliximab is a chimeric human/murine IgG1 monoclonal antibody (mAb; adalimumab, and golimumab are human mAbs; certolizumab pegol is composed of the fragment antigen-binding anti-binding domain of a humanized anti-TNF-α mAb, combined with polyethylene glycol to increase its half-life in the body; etanercept is a fusion protein that acts as a “decoy receptor” for TNF-α. In this paper, we will briefly review the current data on efficacy and safety of adalimumab in patients with RA, its potential beneficial effects upon comorbid conditions, such as endothelial dysfunction and accelerated atherosclerosis in RA, and the immunogenicity.Keywords: adalimumab, efficacy, safety, rheumatoid arthritis, VEGF, immunogenicity, infections

  9. Bilinguismes ou bi- appartenances

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    Jean-Charles Vegliante

    2012-10-01

    Full Text Available Dans cet essai, l’auteur évoque son sentiment de bi-appartenance lorsqu’il séjourne à Sienne, une de ses villes de prédilection. A l’occasion d’un congrès sur le thème : « Repenser la Méditerranée », ou de la projection d’un film évoquant les lendemains de massacres, il soulève des questions existentielles, en particulier la nécessité de « se parler ». Le bilinguisme se définit selon l’auteur comme une nécessité, une volonté de mieux entendre l’autre. Il évoque les exemples des poètes italiens Giuseppe Ungaretti (parfaitement francophone et Gabriele D’Annunzio, de l’allemand Franz Kafka et de l’anglais Milton. L’auteur passe du français à l’italien : « Lost in translation ?», comme il le dit plaisamment en conclusion.

  10. Clinical utility of circulating tumor cell counting through CellSearch®: the dilemma of a concept suspended in Limbo

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    Raimondi C

    2014-04-01

    Full Text Available Cristina Raimondi,1 Angela Gradilone,1 Giuseppe Naso,2 Enrico Cortesi,2 Paola Gazzaniga1 1Dipartimento Medicina Molecolare, Sapienza Università di Roma, Rome, Italy; 2Dipartimento di Scienze Radiologiche, Oncologiche e Anatomopatologiche, Sapienza Università di Roma, Rome, Italy Abstract: To date, 10 years after the first demonstration of circulating tumor cells (CTCs, prognostic significance in metastatic breast cancer using the US Food and Drug Administration–cleared system CellSearch®, the potential utility of CTCs in early clinical development of drugs, their role as a surrogate marker of response to therapy, and their molecular analysis for patient stratification for targeted therapies are still major unsolved questions. Great expectations are pinned on the ongoing interventional trials aimed to demonstrate that CTCs might be of value for guiding treatment of patients and predicting cancer progression. To fill the gap between theory and practice with regard to the clinical utility of CTCs, a bridge is needed, taking into account innovative design for clinical trials, a revised definition of traditional CTCs, next-generation CTC technology, the potential clinical application of CTC analysis in non-validated settings of disease, and finally, expanding the number of patients enrolled in the studies. In this regard, the results of the first European pooled analysis definitely validated the independent prognostic value of CTC counting in metastatic breast cancer patients. Keywords: CTC, clinical trials, prognosis

  11. Ornella Labriola: the loneliness of an irreducible memory

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    Maria Antonietta Selvaggio

    2017-01-01

    (1908-1991, who lived between Italy and Soviet Union. She was a guest of the famous hotel “Lux” in Moscow, the dwelling place of international Communism during the years of Stalinism. In that place, happened her love story with Giuseppe Rimola (1905-1938, delegate of Italian young communists in the Kjm (the Young Communist International. He was arrested and condemned to death as ”people’s enemy” in the gyre concerning he terror of Stalinism. During all her life, Ornella Labriola only desired to show people the truth about the death of her own partner, also to rescue the sense of her own existence and choices. The biographical approach of our research permits to emphasize witness’s feelings, believes, values and auto-reflexivity. Labriola was interviewed a year before her death. Her narration is focused on her relationship with ideology, with the revolutionary time when she grew, with the political treat as it was perceived during the thirties and forties; but also she talked about her love relation with her partner in a cultural context in which it was normal to sacrifice own private life on the altar of revolutionary necessities.

  12. Anila Hanxhari (Durrës, 1974

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    María Antonia Blat Mir

    2017-01-01

    Full Text Available Anila Hanxhari nació en Durrës (Albania y vive en Lanciano (Italia. Es poetisa, pintora, narradora, traductora y presidenta de la asociación cultural Italfida, con la que ha ideado y organizado diversas actividades culturales y congresos internacionales. Actualmente es directora responsable del sector cultural de Ascom Abruzzo ocupándose de la iniciativa “Poesia e Impresa”. Ha publicado las antologías de poesía Io tu e l’Anima (Ianieri, 1997, Assopita erba dell’est (Noubs, 2002, Cicatrici d’acqua (Noubs, 2007, con prólogo de Giuseppe Conte, Brindisi degli angeli (La Vita Felice, 2012, con prólogo de Maurizio Cucchi, Tiro a sorte la libertà (Tabula Fati, 2016, con prólogo de Davide Rondoni y Rolando D’Alonzo. Sus poemas han aparecido, entre otras, en las antologías Nuovissima poesia italiana (Oscar Mondadori, 2005, editada por Antonio Riccardi y Maurizio Cucchi, La parola che ricostruisce. Poeti italiani per l’Aquila (Tracce, 2009, además de en la colección Specchio de La Stampa y en numerosas revistas. Ha ganado diferentes premios, como el Premio Camaiore-Proposta (2002, el Premio Matacotta a la opera prima 2003, el Premio Valle Senio o el premio Poesia nella vita (2011.

  13. Survey report for fiscal 1998. Joint research project with researchers related to petroleum substituting energies in the EU countries; 1998 nendo EU shokoku no sekiyu daitai energy kanren kenkyusha tono kyodo kenkyu jigyo chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    It was intended to invite researchers related to petroleum substituting energies from the EU countries to perform joint researches at research organizations under the auspices of the Agency of Industrial Science and Technology having deep relations with research themes of the invited researchers, to deepen the mutual understanding, and to form efficient cooperative relationship. The intention is also to contribute to research and development of petroleum substituting energies to be used in Japan in the future. The research themes, researchers, their research organizations, and the receiving research organizations are as follows: (1) evaluation of reservoir impedance in high-temperature rock experimental fields by Mr. Ralph Weidler (Germany) at Ruhr University received by the Resource and Environmental Technology Research Institute; (2) changing the particle boundary structure of ceramics by using the alkoxide process by Dr. Ramon Torrecillas (Spain) at Institute Nacional del Carbon received by the Nagoya Industrial Technology Research Institute; (3) research on corrosion in metallic materials for molten carbonate type fuel cells by Dr. Giuseppe Calogero (Italy) at Institute for Transformation and Storage of Energy received by the Osaka Industrial Technology Research Institute; and (4) estimation of behavior of deep geothermal reservoirs with high enthalpy by Dr. Enrico Maranini at Universita' Di Ferrara received by the Geology Survey Center. (NEDO)

  14. Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study

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    Alessandrini G

    2012-02-01

    Full Text Available Enzo Emanuele1, Marco Bertona1, Karmela Altabas2, Velimir Altabas2, Giuseppe Alessandrini31Department of Health Sciences, University of Pavia, Pavia, Italy; 2Clinical Hospital "Sestre Milosrdnice", Zagreb, Croatia; 3Dermatology Clinics, Ugento, ItalyPurpose: Acne vulgaris is a skin disorder of the sebaceous follicles, involving hyperkeratinization and perifollicular inflammation. Aberrant extracellular matrix remodeling due to matrix metalloproteinases (MMPs has been associated with the presence of acne conditions. Given the complex pathophysiology of acne, novel topical therapies should include combination products that target multiple pathogenetic mechanisms. In this pilot study we investigated the changes in gene expression of extracellular MMPs, the tissue inhibitors of metalloproteinases, and proinflammatory molecules after 45 days of topical application of a combination product containing nicotinamide, retinol, and 7-dehydrocholesterol in 16 patients with inflammatory acne on their back.Materials and methods: Skin biopsies were obtained before and after treatment for gene expression studies.Results: Quantitative real-time polymerase chain reaction revealed a significant downregulation of MMP-1, MMP-2, MMP-9, MMP-14, interleukin-6, monocyte chemoattractant protein-1, and macrophage migration inhibitory factor. In contrast, the tissue inhibitors of metalloproteinases and transforming growth factor-ß1 were significantly upregulated. The gene expression findings correlated well with the clinical treatment response.Conclusions: The combination of nicotinamide, retinol, and 7-dehydrocholesterol appears to be effective for acne treatment from both clinical and molecular standpoints.Keywords: acne, gene expression, topical treatment, matrix metalloproteinases, inflammation

  15. The Case of Capogrossi in Rome: Collecting Data with Different Technologies on a Contemporary Mural Painting

    Science.gov (United States)

    Mezzadri, P.; Russo, J.

    2017-05-01

    This paper focuses on the presentation of a part of the main thematic data documenting the pathologies and the degradation problems of a contemporary mural painting, which was designed and carried out by the italian artist Giuseppe Capogrossi in 1954. This forgotten masterpiece is developed on the ceilings of the main double stairscase at the entrance of the Airone, an ex-cinema-theatre in Rome (Italy). In time, the original project was completely damaged and now the Airone cinema is abandoned since 1999; the decoration, strictly connected to the function of the original project, has been completely covered by synthetic coatings. The documentation of the observed pathologies and the original materials of the lower ceiling takes place during a restoration project in 2015-2016 and was accomplished by utilizing different technologies in order to facilitate the collecting of the main data within several graphic thematic tables. The challenge of this documentation was to create a contact point, and perhaps also a contamination, between the practices of CAD graphic documentation, restoration and GIS technology.

  16. Patient perspectives in the management of asthma: improving patient outcomes through critical selection of treatment options

    Directory of Open Access Journals (Sweden)

    Nicola Scichilone

    2010-02-01

    Full Text Available Nicola Scichilone, Adele Contino, Giovanni Battista Figlioli, Giuseppe Paglino, Vincenzo BelliaDipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana (DIMPEFINU, University of Palermo, Palermo, ItalyAbstract: Asthma is a chronic inflammatory disorder of the airways that requires long-term treatment, the goal of which is to control clinical symptoms for extended periods with the least possible amount of drugs. International guidelines recommend the addition of an inhaled long-acting beta2-agonist (LABA to a low- to medium-dose inhaled corticosteroid (ICS when low doses of ICS fail to control asthma symptoms. The fixed combined administration of ICS/LABA improves patient compliance, reducing the risk of therapy discontinuation. The relative deposition pattern of the inhaled drug to the target site is the result of a complex interaction between the device used, the aerosol formulation and the patient’s adherence to therapy. Different inhalation devices have been introduced in clinical practice over time. The new hydrofluoroalkane (HFA solution aerosols allow for the particle size to be modified, thus leading to deeper penetration of the medication into the lung. The Modulite® technology allows for the manipulation of inhaled HFA-based solution formulations, such as the fixed beclomethasone/formoterol combination, resulting in a uniform treatment of inflammation and bronchoconstriction. The success of any anti-asthmatic treatment depends on the choice of the correct device and the adherence to therapy.Keywords: asthma, therapy, inhalers, compliance

  17. Update on the clinical use of the low-molecular-weight heparin, parnaparin

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    Giuseppe Camporese

    2009-09-01

    Full Text Available Giuseppe Camporese1, Enrico Bernardi2, Franco Noventa31Unit of Angiology and 3Department of Clinical and Experimental Medicine, Clinical Epidemiology Group, University Hospital of Padua, Italy; 2Department of Emergency and Accident Medicine, Hospital of Conegliano Veneto, ItalyAbstract: Parnaparin is a low-molecular-weight heparin that has widely shown its efficacy and safety in prevention of venous thromboembolism, in the treatment of chronic venous disorders, and in the treatment of venous and arterial (stable and unstable angina, acute ST-segment elevation myocardial infarction thrombosis. Parnaparin at the respective dosages of 3200, 4250, 6400, or 12800 IUaXa for a period ranging from 3 to 5 days to 6 months, is usually administered subcutaneously by means of once-daily regimen and is better tolerated than unfractionated heparin at the injection site. In the variety of commercially available low-molecular-weight heparins, parnaparin represents a useful therapeutic option, even though little evidence is available comparing the superiority or the equivalent efficacy and safety of parnaparin to that of the unfractionated heparin or placebo. This review summarizes the available literature on the use of parnaparin in different settings of cardiovascular diseases, including papers published during the past year and ongoing studies.Keywords: low-molecular-weight heparin, heparin, parnaparin, acute coronary syndromes, venous thromboembolism

  18. Dabrafenib: a new opportunity for the treatment of BRAF V600-positive melanoma

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    Banzi M

    2016-05-01

    Full Text Available Maria Banzi,1 Simona De Blasio,2 Aimilios Lallas,3 Caterina Longo,2 Elvira Moscarella,2 Roberto Alfano,4 Giuseppe Argenziano5 1Department of Medical Oncology, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy; 2Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy; 3First Department of Dermatology, Aristotle University, Thessaloniki, Greece; 4Department of Anesthesiology, Surgery and Emergency, 5Dermatology Unit, Second University of Naples, Naples, Italy Abstract: Prior to 2011, the 1-year survival rates for patients suffering from advanced or metastatic melanoma was as low as 33%, with a median overall survival of about 9 months. Several chemotherapeutic regimens have been applied, either as monochemotherapy or as polychemotherapy, overall not resulting in an improvement of progression-free or overall survival. Novel insights into the epidemiology and biology of melanoma allowed the development of newer therapies. The discovery of mutations in BRAF, a part of the mitogen-activated protein kinase, allowed the development of two BRAF inhibitors, vemurafenib and dabrafenib, which significantly improved the outcome of metastatic melanoma treatment. This article reviews the mechanism of action, efficacy, and safety profile of dabrafenib. An in-depth knowledge of this medication will encourage clinicians to select the appropriate therapeutic strategy for each patient, as well as to prevent or adequately manage side effects, optimizing, thus, the drug’s applicability. Keywords: melanoma, BRAF, target therapy, dabrafenib, melanoma survival

  19. The effect of a cognitive-motor intervention on voluntary step execution under single and dual task conditions in older adults: a randomized controlled pilot study

    Directory of Open Access Journals (Sweden)

    Pichierri G

    2012-07-01

    Full Text Available Giuseppe Pichierri,1 Amos Coppe,1 Silvio Lorenzetti,2 Kurt Murer,1 Eling D de Bruin11Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology, ETH Zurich, Switzerland; 2Institute for Biomechanics, Department of Health Sciences and Technology, ETH Zurich, SwitzerlandBackground: This randomized controlled pilot study aimed to explore whether a cognitive-motor exercise program that combines traditional physical exercise with dance video gaming can improve the voluntary stepping responses of older adults under attention demanding dual task conditions.Methods: Elderly subjects received twice weekly cognitive-motor exercise that included progressive strength and balance training supplemented by dance video gaming for 12 weeks (intervention group. The control group received no specific intervention. Voluntary step execution under single and dual task conditions was recorded at baseline and post intervention (Week 12.Results: After intervention between-group comparison revealed significant differences for initiation time of forward steps under dual task conditions (U = 9, P = 0.034, r = 0.55 and backward steps under dual task conditions (U = 10, P = 0.045, r = 0.52 in favor of the intervention group, showing altered stepping levels in the intervention group compared to the control group.Conclusion: A cognitive-motor intervention based on strength and balance exercises with additional dance video gaming is able to improve voluntary step execution under both single and dual task conditions in older adults.Keywords: fall prevention, exercise, dance, video game

  20. Current options for the treatment of Paget’s disease of the bone

    Directory of Open Access Journals (Sweden)

    Daniela Merlotti

    2009-07-01

    Full Text Available Daniela Merlotti, Luigi Gennari, Giuseppe Martini, Ranuccio NutiDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Siena, ItalyAbstract: Paget’s disease of bone (PDB is a chronic bone remodeling disorder characterized by increased osteoclast-mediated bone resorption, with subsequent compensatory increases in new bone formation, resulting in a disorganized mosaic of woven and lamellar bone at affected skeletal sites. This disease is most often asymptomatic but can be associated with bone pain or deformity, fractures, secondary arthritis, neurological complications, deafness, contributing to substantial morbidity and reduced quality of life. Neoplastic degeneration of pagetic bone is a relatively rare event, occurring with an incidence of less than 1%, but has a grave prognosis. Specific therapy for PDB is aimed at decreasing the abnormal bone turnover and bisphosphonates are currently considered the treatment of choice. These treatments are associated with a reduction in plasma alkaline phosphatase (ALP activity and an improvement in radiological and scintigraphic appearance and with a reduction in bone pain and bone deformity, Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this debilitating disorder.Keywords: Paget’s disease of bone, bisphosphonates, aminobisphosphonates, bone remodeling

  1. Minimally invasive surgery for Achilles tendon pathologies

    Directory of Open Access Journals (Sweden)

    Nicola Maffulli

    2010-07-01

    Full Text Available Nicola Maffulli1, Umile Giuseppe Longo2, Filippo Spiezia2, Vincenzo Denaro21Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, London, England; 2Department of Orthopedic and Trauma Surgery, Campus Bio-Medico University, Rome, ItalyAbstract: Minimally invasive trauma and orthopedic surgery is increasingly common, though technically demanding. Its use for pathologies of the Achilles tendon (AT hold the promise to allow faster recovery times, shorter hospital stays, and improved functional outcomes when compared to traditional open procedures, which can lead to difficulty with wound healing because of the tenuous blood supply and increased chance of wound breakdown and infection. We present the recent advances in the field of minimally invasive AT surgery for tendinopathy, acute ruptures, chronic tears, and chronic avulsions of the AT. In our hands, minimally invasive surgery has provided similar results to those obtained with open surgery, with decreased perioperative morbidity, decreased duration of hospital stay, and reduced costs. So far, the studies on minimally invasive orthopedic techniques are of moderate scientific quality with short follow-up periods. Multicenter studies with longer follow-up are needed to justify the long-term advantages of these techniques over traditional ones.Keywords: tendinopathy, rupture, percutanous repair, less invasive

  2. Spreading scientific philosophies with instruments: the case of Atwood's machine

    CERN Document Server

    Esposito, S

    2012-01-01

    We study how the paradigm of Newton's science, based on the organization of scientific knowledge as a series of mathematical laws, was definitively accepted in science courses - in the last decades of the XVIII century, in England as well as in the Continent - by means of the "universal" dynamical machine invented by George Atwood in late 1770s just for this purpose. The spreading of such machine, occurred well before the appearance of Atwood's treatise where he described the novel machine and the experiments to be performed with it, is a quite interesting historical case, which we consider in some detail. In particular, we focus on the "improvement" introduced by the Italian Giuseppe Saverio Poli and the subsequent "simplifications" of the machine, underlying the ongoing change of perspective after the definitive success of Newtonianism. The case studied here allows to recognize the relevant role played by a properly devised instrument in the acceptance of a new paradigm by non-erudite scholars, in addition ...

  3. Bioresorbable vascular scaffolds technology: current use and future developments

    Directory of Open Access Journals (Sweden)

    Giacchi G

    2016-07-01

    Full Text Available Giuseppe Giacchi, Luis Ortega-Paz, Salvatore Brugaletta, Kohki Ishida, Manel Sabaté Cardiology Department, Clinic Cardiovascular Institute, Hospital Clinic, August Pi and Sunyer Biomedical Research Institute (IDIBAPS, University of Barcelona, Barcelona, Spain Abstract: Coronary bioresorbable vascular scaffolds are a new appealing therapeutic option in interventional cardiology. The most used and studied is currently the Absorb BVS™. Its backbone is made of poly-l-lactide and coated by a thin layer of poly-d,l-lactide, it releases everolimus and is fully degraded to H2O and CO2 in 2–3 years. Absorb BVS™ seems to offer several theoretical advantages over metallic stent, as it gives temporary mechanical support to vessel wall without permanently caging it. Therefore, long-term endothelial function and structure are not affected. A possible future surgical revascularization is not compromised. Natural vasomotion in response to external stimuli is also recovered. Several observational and randomized trials have been published about BVS clinical outcomes. The main aim of this review is to carry out a systematic analysis about Absorb BVS™ studies, evaluating also the technical improvements of the Absorb GT1 BVS™. Keywords: Absorb GT1, Absorb BVS™, bioresorbable vascular scaffold, BRS, coronary scaffold

  4. I modelli istituzionali di integrazione musulmana in Europa e il caso dell’ “Islám italiano”

    Directory of Open Access Journals (Sweden)

    Salvatore Prisco

    2011-02-01

    Full Text Available Il testo (ultimato il 24 febbraio 2011 fonde - aggiornandoli nella considerazione degli sviluppi successivi alle circostanze che hanno dato occasione alle rispettive trattazioni originarie - i temi svolti durante l’intervento nella tavola rotonda finale sul tema La Carta dei valori della cittadinanza e dell’integrazione (alla quale parteciparono, con chi scrive, Michele Lepri Gallerano, Massimo Papa e Giuseppe Verde, moderatore Raffaele Coppola al Convegno delle Università di Bari e del Salento sul tema Libertà religiosa e Multiculturalismo (Gallipoli, 29 febbraio-1 marzo 2008, i cui Atti sono in corso di pubblicazione nel volume omonimo, a cura di R. Coppola, V. Tondi della Mura, V. Turchi, ESI, Napoli, e nella relazione al Convegno sul tema La tutela dei minori di cultura islamica nell’area mediterranea. Aspetti sociali, giuridici, medici, organizzato dalla Facoltà di Studi arabo-islamici e del Mediterraneo dell’Università L’Orientale (Napoli, 28-29 ottobre 2009, i cui Atti sono anch’essi in via di pubblicazione. Il presente lavoro è destinato alla pubblicazione anche negli Studi in onore di Aldo Lojodice.

  5. O modelo constitucional de processo e o eixo estrutural da processualidade democrática

    Directory of Open Access Journals (Sweden)

    Leonardo Augusto Marinho Marques

    2016-09-01

    Full Text Available Neste artigo, analisar-se-á a relação entre Constituição e processo, a partir de teorias que surgiram na segunda metade do século XX.  Passando pelo pensamento de Eduardo Couture, Héctor Fix-Zamudio, Elio Fazzalari e Italo Andolina e Giuseppe Vignera, apresentar-se-á o modelo constitucional de processo como referencial teórico que permite compreender o processo como garantia. No modelo constitucional, os princípios da não-parcialidade do juízo, contraditório, ampla argumentação e fundamentação da decisão se interligam, legitimando o ato jurisdicional que repercute na esfera de direitos dos cidadãos. Assim, pretende-se demonstrar que eixo estrutural da processualidade democrática é extraído desse núcleo principiológico.

  6. Importance of perforating vessels in nipple-sparing mastectomy: an anatomical description

    Directory of Open Access Journals (Sweden)

    Amanti C

    2015-07-01

    Full Text Available Claudio Amanti,1 Valeria Vitale,1 Augusto Lombardi,1 Stefano Maggi,1 Laura Bersigotti,1 Gianni Lazzarin,1 Emiliano Nuccetelli,1 Camilla Romano,1 Laura Campanella,1 Lara Cristiano,2 Alessandra Bartoloni,2 Giuseppe Argento2 1Breast Surgery Unit, 2Radiology Unit, University of Roma, La Sapienza Sant'Andrea Hospital, Rome, Italy Background: Nipple-sparing mastectomy (NSM, understood as an oncologically valid procedure, is relatively new, and is an evolution of traditional mastectomy, particularly in relation to breast-conserving surgery. The anterior perforating branches are responsible for the cutaneous vascularization of the breast skin, and their preservation is a fundamental step to avoid possible postoperative necrosis. Therefore, evaluating the potential complications of cancer-related reconstructive surgical procedures such as NSM, both the distance of the tumoral lesion from the skin and the surgical incision site should be carefully considered. The preferred site of incision corresponds to the inframammary fold or possibly the periareolar area.Methods: We retrospectively reviewed 113 patients who underwent NSM from January 2005 to October 2012 to evaluate skin complications. The anatomical study was performed by magnetic resonance imaging of the breast.Results: Only one of the 113 women who had undergone a NSM procedure had total necrosis (0.9% and six patients had partial necrosis (5.8% of the nipple-areola complex. Keywords: nipple-sparing mastectomy, breast, magnetic resonance imaging, breast perforating vessels, breast anatomy

  7. Staff members with 25 years' service at CERN in 2005

    CERN Multimedia

    2005-01-01

    The 74 staff members who have spent 25 years at CERN in 2005 were invited by the Director-General to a reception in their honour on 22 November. ADRIAN Gilbert / AB ALLIOD Marie-Noëlle / AB ANTOINET Gérard / SC AUBERT Marc / TS AUQUIER Christian / SC BAIRD Simon / AB BARRAS Suzanne / PH BAUD Richard / AT BELLONI Jean / SC BERTUOL Gilbert / SC BLANC Jean-Luc / AB BONVALLET Guy / SC BOSSUS Patrice / SC BROERE Johannes / AB BRU Yvon / TS BURDAIRON Alain / TS CANARD Philippe / AT CAVALLO Patrice / SC CHARRA Patrick / PH CHATAIGNEAU Marc / SC COLIN Gilles / SC DAHLEN Pierre / AB DE GROOT Johannes / PH DEDOBBELER Bernard / TS DELCAMBRE Jean Pierre / SC DELENCLOS Yves / TS DEROYER Patrick / SC DESBISSONS Christian / SC DRAPER Mick / AB DROUX Pascal / FI DUCASTEL Claude / TS DUMUR Alain / SC FOCKER Gerrit / AB FOFFANO Giuseppe / TS FORRAT Isabelle / IT FREI Marie-José / DSU FRESSARD Michel / TS GAGNIERE Daniel / TS GIUDICI Pierre-Ange / PH GOICOECHEA Bernard / TS GUEHO Alain / TS GUENEHEC François / SC JE...

  8. Tracking the 2015 Gastrointestinal Cancers Symposium: bridging cancer biology to clinical gastrointestinal oncology

    Directory of Open Access Journals (Sweden)

    Aprile G

    2015-05-01

    Full Text Available Giuseppe Aprile,1 Francesco Leone,2,3 Riccardo Giampieri,4 Mariaelena Casagrande,1 Donatella Marino,2,3 Luca Faloppi,4 Stefano Cascinu,4 Gianpiero Fasola,1 Mario Scartozzi5,6 1Department of Oncology, University and General Hospital, Udine, Italy; 2Medical Oncology Department, University of Turin, 3Institute for Cancer Research and Treatment, Candiolo, Turin, Italy; 4Medical Oncology Unit, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Universita Politecnica delle Marche, Ancona, Italy; 5Medical Oncology Department, University of Cagliari, 6General Hospital, Cagliari, Italy Abstract: The 2015 Gastrointestinal Cancers Symposium (San Francisco, CA, USA; January 15–17 is the world-class conference co-sponsored by the American Society of Clinical Oncology, the American Society for Radiation Oncology, the American Gastroenterological Association Institute, and the Society of Surgical Oncology, in which the most innovative research results in digestive tract oncology are presented and discussed. In its twelfth edition, the meeting has provided new insights focusing on the underpinning biology and clinical management of gastrointestinal malignancies. More than 3,400 health care professionals gathered from all over the world to share their experiences on how to bridge the recent novelties in cancer biology with everyday medical practice. In this article, the authors report on the most significant advances, didactically moving on three different anatomic tracks: gastroesophageal malignancies, pancreatic and biliary cancers, and colorectal adenocarcinomas. Keywords: colorectal cancer, gastric cancer, ramucirumab, pembrolizumab, target therapy, onartuzumab, AMG 337

  9. New developments in the management of advanced melanoma – role of pembrolizumab

    Directory of Open Access Journals (Sweden)

    Improta G

    2015-09-01

    Full Text Available Giuseppina Improta,1 Isabella Leone,1 Marco Donia,2 Stefania Gieri,3 Giuseppe Pelosi,4,5 Filippo Fraggetta6 1Laboratory of Clinical Research and Advanced Diagnostics, IRCCS-CROB, Rionero in Vulture, Potenza, Italy; 2Center for Cancer Immune Therapy, Department of Hematology, Copenhagen University Hospital, Herlev, Denmark; 3Laboratory of Oncologic Technologies, IBFM-CNR, Cefalù, Potenza, 4Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, 5Department of Biomedical and Clinical Sciences “Luigi Sacco”, Università degli Studi di Milano, Milan, 6Department of Pathology, Cannizzaro Hospital, Catania, Italy Abstract: Cancer immunotherapy is now recognized to be fundamental in modern oncology, because immune system recruitment may represent a powerful and innovative strategy in cancer therapy. Pembrolizumab, a highly selective humanized monoclonal antibody directly blocking the interaction between programmed cell death-1 expressed by tumor-associated T-cells and its ligand programmed cell death-L1 present on tumor and stromal cells, was recently approved by US Food and Drug Administration for the treatment of patients with unresectable or metastatic melanoma and disease progression upon ipilimumab and BRAF inhibitor. This review will focus on the clinical development and use of pembrolizumab in the clinical practice and in the management of advanced melanoma. Keywords: advanced melanoma, immunotherapy, PD-1 inhibitor, pembrolizumab

  10. 1861-1981: Statistics teaching in Italian universities

    Directory of Open Access Journals (Sweden)

    Donata Marasini

    2013-05-01

    Full Text Available This paper aims to outline the development of Statistics from 1861 to 1981 with respect to its contents. The paper pays particular attention to some statistical topics which have been covered by basic introductory courses in the Italian Universities since the beginning of the Italian unification. The review takes as its starting point the well-known book “Filosofia della Statistica” of Melchiorre Gioja. This volume was published 35 years before Italian unification but it already contains the fundamental topics of exploratory and inductive Statistics. These topics give the opportunity to mention Italian statisticians who are considered the pioneers of this discipline. In particular, the attention is focused on four statisticians: Corrado Gini, well-known for its modern insights; Marcello Boldrini, high cultured man also in the epistemological field; Bruno de Finetti, founder of subjective school and Bayesian reasoning; Giuseppe Pompilj, precursor of random variables and sampling theory. The paper browses the indexes of three well-known Italian handbooks that, although published after the period 1861-1981, deal with topics covered in some basic teachings of exploratory statistics, statistical inference and sampling theory from finite population.

  11. Winter Atomiades 2014: CERN skiers win 31 medals!

    CERN Multimedia

    CERN Bulletin

    2014-01-01

    The 12th Winter Atomiades took place at Flachau, Austria, from 8 to 15 March 2014. The event, organised by the Association of the Sports Communities of the European Research Institutes (see here), brought together 18 research centres, including CERN, AIT, ESRF, PSI and many others, with a total of about 280 participants.   Lots of fun and a great result for the 13 CERN skiers at the 2014 Winter Atomiades in Flachau, Austria. From left to right and from bottom to top: Lennart Jirden (PH), Anna Lipniacka (PH), Guillaume Michet (DGS), Vera Chetvertkova (TE), Thierry Boileau (external), Jean-Louis Grenard (EN), Clement Bovet (EN), Marc Tavlet (BE), Rob Knoops (PH), Giuseppe Lo Presti (IT), Simone Campana (IT), Sylviane Gander (external) and Javier Pablos (TE).   The team of 13 athletes from six different CERN departments won 31 medals across all disciplines, in a spirit of fun and fair play. CERN came second in the general ranking of all participating institutes! The next Winter Atomiades...

  12. Electrical Resistivity Tomographies on the detection of adobe buried archaeological structures in Piramide Sur in Cahuachi (Peru)

    Science.gov (United States)

    Capozzoli, L.; Masini, N.; Rizzo, E.; Lasaponara, R.; Orefici, G.

    2012-04-01

    During the last two decades of excavations, adobe pyramids dating back from the 6th century B.C. to the 4th century A.D have been unearthed in the ancient Ceremonial Centre of Cahuachi near Nasca (Peru) by an Italian-Peruvian mission directed by Giuseppe Orefici. One of the archaeological sectors, called sector A, has been almost excavated and restored. To complete sector A only a terraced mound named "Piramide Sur" needs to be excavated. In order to provide useful information on the presence of buried structures and platforms as well on the geological stratigraphy a multi-scale approach based on the integration of satellite remote sensing with geophysical techniques was employed. Such investigations were carried out by the Italian mission ITACA, funded by the Italian Ministry Affairs and composed of researchers of two institutes of CNR (IMAA and IBAM), which provides a scientific support for archaeological research, since 2007. In particular, the subsurface features were investigated by Geoelectrical prospecting, performed by using a georesistivimeter for tomography which observe the resistivity value along sections. Several tomographies were carried out to investigate the shallow and deep structure of the pyramid both along the main flank at Nord and on the top. Finally, the integration of all data acquired by the different remote sensing techniques allowed for spatially characterizing the archaeological features, thus providing important information for the planning of the next archaeological campaign.

  13. Manipulation of tumor oxygenation and radiosensitivity through modification of cell respiration. A critical review of approaches and imaging biomarkers for therapeutic guidance.

    Science.gov (United States)

    Gallez, Bernard; Neveu, Marie-Aline; Danhier, Pierre; Jordan, Bénédicte F

    2017-08-01

    Tumor hypoxia has long been considered as a detrimental factor for the response to irradiation. In order to improve the sensitivity of tumors cells to radiation therapy, tumor hypoxia may theoretically be alleviated by increasing the oxygen delivery or by decreasing the oxygen consumption by tumor cells. Mathematical modelling suggested that decreasing the oxygen consumption should be more efficient than increasing oxygen delivery in order to alleviate tumor hypoxia. In this paper, we review several promising strategies targeting the mitochondrial respiration for which alleviation of tumor hypoxia and increase in sensitivity to irradiation have been demonstrated. Because the translation of these approaches into the clinical arena requires the use of pharmacodynamics biomarkers able to identify shift in oxygen consumption and tumor oxygenation, we also discuss the relative merits of imaging biomarkers (Positron Emission Tomography and Magnetic Resonance) that may be used for therapeutic guidance. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Face-n-Food: Gender Differences in Tuning to Faces

    Science.gov (United States)

    Pavlova, Marina A.; Scheffler, Klaus; Sokolov, Alexander N.

    2015-01-01

    Faces represent valuable signals for social cognition and non-verbal communication. A wealth of research indicates that women tend to excel in recognition of facial expressions. However, it remains unclear whether females are better tuned to faces. We presented healthy adult females and males with a set of newly created food-plate images resembling faces (slightly bordering on the Giuseppe Arcimboldo style). In a spontaneous recognition task, participants were shown a set of images in a predetermined order from the least to most resembling a face. Females not only more readily recognized the images as a face (they reported resembling a face on images, on which males still did not), but gave on overall more face responses. The findings are discussed in the light of gender differences in deficient face perception. As most neuropsychiatric, neurodevelopmental and psychosomatic disorders characterized by social brain abnormalities are sex specific, the task may serve as a valuable tool for uncovering impairments in visual face processing. PMID:26154177

  15. Faces on Her and His Mind: Female and Likable.

    Science.gov (United States)

    Pavlova, Marina A; Mayer, Annika; Hösl, Franziska; Sokolov, Alexander N

    2016-01-01

    Faces are a valuable source of non-verbal information for daily life social interaction. Mounting evidence points to gender specificity in face perception. Here we search for the factors that can potentially trigger gender differences in tuning to faces. By using a set of Face-n-Food images slightly bordering on the Giuseppe Arcimboldo style, we examine: (i) whether face resemblance is linked to gender specific face impression, and, if so, whether this association is perceiver gender specific; and (ii) whether images most resembling a face are also most likable for female and male perceivers. First, in a spontaneous recognition task, participants were shown a set of Face-n-Food images in a predetermined order from the least to most resembling a face. Then in a two-alternative forced-choice (2AFC) task, participants judged whether each face appeared for them (i) either female or male (Exp. 1); or (ii) either likable or unlikable (Exp. 2). Remarkably, face resemblance is closely connected to gender specific impressions: images more resembling a face elicit also more female-face responses. This link is not perceiver gender specific as it occurs for both females and males. Moreover, face resemblance is positively linked to face likability, but this holds true only for female perceivers. The findings shed light on gender specificity in tuning to faces, and help to clarify abnormalities of the social brain in neurodevelopmental, psychiatric and psychosomatic disorders.

  16. Clinical experience and critical evaluation of the role of sorafenib in renal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Zustovich F

    2011-05-01

    Full Text Available Fable Zustovich1, Giuseppe Lombardi1, Davide Pastorelli1, Patrizia Farina1, Massimo Dal Bianco2, Luca De Zorzi2, Maurizia Dalla Palma1, Ornella Nicoletto1, Vittorina Zagonel11Oncologia Medica 1, Istituto Oncologico Veneto-IRCCS, Padova, Italy; 2UO Urologia, Ospedale Sant'Antonio, ULSS 16, Padova, ItalyAbstract: Renal cell carcinoma (RCC is a common malignancy worldwide with approximately 95,000 new cases per year and ranks as the sixth cause of cancer deaths. Until recently, the slightly active and very toxic cytokines were available for patients with advanced RCC. Advances have been made in understanding the molecular biology of renal cancer. The introduction of targeted agents has led to promising possibilities for treating these highly vascularized tumors. Angiogenesis inhibition is likely to represent the main potential therapeutic target. Sorafenib is an oral multikinase inhibitor with activity against tyrosine kinase receptors that are responsible for blood vessel development and has shown to be active in treating advanced RCC. In this review, we summarize the pharmacology, mode of action, pharmacokinetics, and safety of sorafenib use in therapy for advanced RCC.Keywords: sorafenib, pharmacokinetics, angiogenesis 

  17. Could Jean-Dominique Cassini see the famous division in Saturn's rings?

    CERN Document Server

    Lozi, Julien; Semery, Alain; Lhomé, Emilie; Jacquinod, Sophie; Combes, Michel; Bernardi, Pernelle; Andretta, Rémi; Motisi, Maxime; Bobis, Laurence; Kaftan, Emilie

    2013-01-01

    Nowadays, astronomers want to observe gaps in exozodiacal disks to confirm the presence of exoplanets, or even make actual images of these companions. Four hundred and fifty years ago, Jean-Dominique Cassini did a similar study on a closer object: Saturn. After joining the newly created Observatoire de Paris in 1671, he discovered 4 of Saturn's satellites (Iapetus, Rhea, Tethys and Dione), and also the gap in its rings. He made these discoveries observing through the best optics at the time, made in Italy by famous opticians like Giuseppe Campani or Eustachio Divini. But was he really able to observe this black line in Saturn's rings? That is what a team of optical scientists from Observatoire de Paris - LESIA with the help of Onera and Institut d'Optique tried to find out, analyzing the lenses used by Cassini, and still preserved in the collection of the observatory. The main difficulty was that even if the lenses have diameters between 84 and 239 mm, the focal lengths are between 6 and 50 m, more than the f...

  18. Fractal Geometry in the Arts: AN Overview across the Different Cultures

    Science.gov (United States)

    Sala, Nicoletta

    Fractal, in mathematics, is a geometric shape that is complex and detailed in structure at any level of magnification. The word "fractal" was coined less than thirty years ago by one of history's most creative and mathematicians, Benoit Mandelbrot, whose work, The Fractal Geometry of Nature, first introduced and explained concepts underlying this new vision of the geometry. Although other mathematical thinkers like Georg Cantor (1845-1918), Felix Hausdorff (1868-1942), Gaston Julia (1893-1978), Helge von Koch (1870-1924), Giuseppe Peano (1858-1932), Lewis Richardson (1891-1953), Waclaw Sierpinski (1882-1969) and others had attained isolated insights of fractal understanding, such ideas were largely ignored until Mandelbrot's genius forged them at a single blow into a gorgeously coherent and fascinating discipline. Fractal geometry is applied in different field now: engineering, physics, chemistry, biology, and architecture. The aim of this paper is to introduce an approach where the arts are analysed using a fractal point of view.

  19. Volumetric capnography: In the diagnostic work-up of chronic thromboembolic disease

    Directory of Open Access Journals (Sweden)

    Marcos Mello Moreira

    2010-05-01

    Full Text Available Marcos Mello Moreira1, Renato Giuseppe Giovanni Terzi1, Laura Cortellazzi2, Antonio Luis Eiras Falcão1, Heitor Moreno Junior2, Luiz Cláudio Martins2, Otavio Rizzi Coelho21Department of Surgery, 2Department of Internal Medicine, State University of Campinas, School of Medical Sciences, Campinas, Sao Paulo, BrazilAbstract: The morbidity and mortality of pulmonary embolism (PE have been found to be related to early diagnosis and appropriate treatment. The examinations used to diagnose PE are expensive and not always easily accessible. These options include noninvasive examinations, such as clinical pretests, ELISA D-dimer (DD tests, and volumetric capnography (VCap. We report the case of a patient whose diagnosis of PE was made via pulmonary arteriography. The clinical pretest revealed a moderate probability of the patient having PE, and the DD result was negative; however, the VCap associated with arterial blood gases result was positive. The patient underwent all noninvasive exams following admission to hospital and again eight months after discharge. Results gained from invasive tests were similar to those produced by image exams, highlighting the importance of VCap as an important noninvasive tool.Keywords: pulmonary embolism, pulmonary hypertension, volumetric capnography, d-dimers, pretest probability

  20. Exploring old caves

    Science.gov (United States)

    Luana Belli, Maria

    2015-04-01

    Quarries, caves and mines often contain fossils. During the '30s in Rome, the urban expansion needs for building materials such as gravel, sand and clay were extracted from quarries that surrounded the city. One of these quarries in particular, in the area of Saccopastore (Nomentana area 3 km from the University Sapienza Roma) returned an ancient human fossil skull belonging to a Neanderthal (most likely a female) who lived in Latium about 120,000 years ago. Detailed studies of this fossil were carried out by Sergio Sergi, the son of the founder of the Museum of Anthropology in Rome, Giuseppe Sergi. The museum was founded in 1884 and was later transferred to the University City (1934) where it is still located. Professor Maria Luana Belli, a science teacher in the Liceo Scientifico "G. Keplero" is a volunteer and collaborator with the Museum "G. Sergi", and she and her students retrace the places of the discovery on the trail of the Neanderthals, for understanding the evolution of the territory in a perspective of interdisciplinary teaching.

  1. Conferenze scelte

    CERN Document Server

    Fantappiè, Luigi

    1993-01-01

    L'opera scientifica di Luigi Fantappiè (1901-1956) si può dividere in tre tappe fondamentali : a) Dal 1923 al 1941 egli si occupò prevalentemente della Teoria dei funzionali analitici, da lui stesso creata. b) Nel 1942 propose la Teoria unitaria del mondo fisico e biologico, completata nel 1947, con l'introduzione del nuovo concetto di "esistenza totale", compatibile con i principi della relatività. c) A partire dal 1952 sviluppò la Teoria degli universi fisici, basata sulla teoria dei gruppi, e nel 1954 dimostrò che la relatività ristretta di Einstein risulta un caso limite di una teoria più perfezionata, la relatività finale. In questo volume vengono presentate alcune conferenze nelle quali Fantappiè espone in forma semplice e divulgativa le sue idee, alla ricerca di una visione armonica ed unitaria del cosmo e della vita. Il lavoro è stato curato dal suo allievo Giuseppe Arcidiacono.

  2. Social Cognition in Williams Syndrome: Face Tuning.

    Science.gov (United States)

    Pavlova, Marina A; Heiz, Julie; Sokolov, Alexander N; Barisnikov, Koviljka

    2016-01-01

    Many neurological, neurodevelopmental, neuropsychiatric, and psychosomatic disorders are characterized by impairments in visual social cognition, body language reading, and facial assessment of a social counterpart. Yet a wealth of research indicates that individuals with Williams syndrome exhibit remarkable concern for social stimuli and face fascination. Here individuals with Williams syndrome were presented with a set of Face-n-Food images composed of food ingredients and in different degree resembling a face (slightly bordering on the Giuseppe Arcimboldo style). The primary advantage of these images is that single components do not explicitly trigger face-specific processing, whereas in face images commonly used for investigating face perception (such as photographs or depictions), the mere occurrence of typical cues already implicates face presence. In a spontaneous recognition task, participants were shown a set of images in a predetermined order from the least to most resembling a face. Strikingly, individuals with Williams syndrome exhibited profound deficits in recognition of the Face-n-Food images as a face: they did not report seeing a face on the images, which typically developing controls effortlessly recognized as a face, and gave overall fewer face responses. This suggests atypical face tuning in Williams syndrome. The outcome is discussed in the light of a general pattern of social cognition in Williams syndrome and brain mechanisms underpinning face processing.

  3. James V. Allaby (1936-2009)

    CERN Multimedia

    2009-01-01

    It was with shock and sorrow that we heard Jim Allaby passed away on 7 April. Jim was born in Preston, England, in October 1936. After obtaining a first degree in physics at King’s College, London, he moved to Liverpool to study for his PhD at the university’s synchrocyclotron. This was his first proton-proton scattering experiment, and was also the start of a lifelong friendship with Bert Diddens, who was there as a CERN fellow. In the early 1960s Jim moved to SLAC where he worked with Dave Ritson on electron inelastic scatterings. Ritson greatly appreciated Jim’s calm and systematic approach to any kind of problem he was confronted with. Thus it was natural for Jim to visit SLAC later and for Ritson to join the DELPHI Collaboration in the 1990s. Jim came to CERN in the summer of 1965. He joined the CERN group of Giuseppe Cocconi, Bert Diddens and Alan Wetherell, who were preparing proton-proton scattering experiments, in a s...

  4. James V. Allaby (1936-2009)

    CERN Multimedia

    2009-01-01

    Jim Allaby standing in front of the target calorimeter of the CHARM neutrino experiment (WA18) .It was with shock and sorrow that we heard Jim Allaby passed away on 7 April. Jim was born in Preston, England, in October 1936. After obtaining a first degree in physics at King’s College, London, he moved to Liverpool to study for his PhD at the university’s synchrocyclotron. This was his first proton-proton scattering experiment, and was also the start of a lifelong friendship with Bert Diddens, who was there as a CERN fellow. In the early 1960s Jim moved to SLAC where he worked with Dave Ritson on electron inelastic scatterings. Ritson greatly appreciated Jim’s calm and systematic approach to any kind of problem he was confronted with. Thus it was natural for Jim to visit SLAC later and for Ritson to join the DELPHI Collaboration in the 1990s. Jim came to CERN in the summer of 1965. He joined the CERN group of Giuseppe Coc...

  5. Dianella Selvatico Estense

    Directory of Open Access Journals (Sweden)

    José Molina

    2014-06-01

    Full Text Available Dianella Selvatico Estense nace en Padova en 1936 y muere en Cortina d’Ampezzo en 1999. Poeta y traductora, Selvatico es un claro ejemplo de la importancia que cobra la traducción en el quehacer poético de una lengua. Sus poemas recurren constantemente a callejones lingüísticos propios de la lengua italiana, haciendo el guiño de su propia labor a sus futuros corresponsales. Tradujo del francés y del inglés para la casa editorial Einaudi a autores como Simone de Beauvoir, Guy de Maupassant, Pierre Jean Jouve y Michael Crichton, entre otros. Sus publicaciones incluyen los libros de poemas Si è sfogliata una rosa (1958, Quando il giorno sarà compiuto (1960, Un giorno all’improvviso (1964 y Nel breve Cerchio (1988. Es autora también de la novela Il senso delle cose (1967. Fue amiga del poeta Giuseppe Ungaretti, quien prologó dos de sus libros. Los poemas presentados aquí forman parte de su poesía póstuma, publicada por Campanotto Editore en el año 2001.

  6. Chögyal Namkhai Norbu — The Master Who Revealed Dzogchen to the Western World

    Directory of Open Access Journals (Sweden)

    Paolo Roberti di Sarsina

    2013-04-01

    Full Text Available Chögyal Namkhai Norbu is one of the last great masters of Dzogchen to have been born and fully educated in Tibet, before the Chinese takeover. He was soon recognized as a great reincarnated lama. This short biography is divided in two parts: the first retraces his steps from his birth in the Tibetan region of Kham until his flight from Tibet to Sikkim, reporting also teachings and initiations he received from his Masters. The second part starts when he arrived in Italy in 1960, invited by Professor Giuseppe Tucci, the greatest Italian Orientalist of his time, to work at the IsMeO, now the Italian Institute for Africa and the Orient (IsIAO. In the 70s Chögyal Namkhai Norbu began to teach Dzogchen to his first students. Interest soon became widespread and having received invitations from all continents, he began to travel and teach throughout the world, founding the worldwide Dzogchen Community, whose main objective is to preserve and develop an understanding of Dzogchen, as well as preserving Tibet's extraordinary cultural patrimony.

  7. Storie ‘vere’ ed eroine dei romanzi. Rappresentare la Somalia in 'Ilaria Alpi. La ragazza che voleva raccontare l’inferno' e 'Non dirmi che hai paura'

    Directory of Open Access Journals (Sweden)

    Simone Brioni

    2016-09-01

    Full Text Available ‘True’ Stories and Heroines in Novels: The Representation of Somalia in Ilaria Alpi: The Young Woman Who Wanted to Narrate Hell and Don’t Tell Me You Are AfraidThis article analyses Gigliola Alvisi’s Ilaria Alpi: La ragazza che voleva raccontare l’inferno [Ilaria Alpi: The Young Woman Who Wanted to Narrate the Hell] (2014 and Giuseppe Catozzella’s Non dirmi che hai paura [Don’t Tell Me You Are Afraid] (2014, two novels that deal with two recent events in Somali and Italian history, the killing of the journalist Ilaria Alpi in Mogadishu in 1994 and the death of Samia Yosuf Omar while she was trying to reach the Italian shores from Libya by boat. Alvisi’s text is analysed in comparison with other fictional and journalistic representations of Ilaria Alpi, while Non dirmi che hai paura is examined through what Catozzella considers the two constitutive dimensions of the novel: documentation and identification. Drawing on Stefano Jossa’s reflections on the construction of literary heroes, the article challenges Alvisi’s and Catozzella’s claims that they represent ‘true stories’. The article also argues that the main characters of these literary works are portrayed as heroines and role models for the emancipation of Muslim women.

  8. Suicide risk in depression and bipolar disorder: Do impulsiveness-aggressiveness and pharmacotherapy predict suicidal intent?

    Directory of Open Access Journals (Sweden)

    Maurizio Pompili

    2008-03-01

    Full Text Available Maurizio Pompili1,2, Marco Innamorati3, Michele Raja4, Ilaria Falcone2, Giuseppe Ducci5, Gloria Angeletti2, David Lester6, Paolo Girardi2, Roberto Tatarelli2, Eleonora De Pisa21McLean Hospital, Harvard Medical School, Boston, MA, USA; 2Department of Psychiatry, Sant’Andrea Hospital, “Sapienza” University of Rome, Italy; 3Università Europea di Roma, Italy; 4Diagnostic and Therapeutic Psychiatric Services, Department of Mental Health, Santo Spirito Hospital, Rome, Italy; 5Diagnostic and Therapeutic Psychiatric Services, Department of Mental Health, San Filippo Neri Hospital, Rome, Italy; 6Center for the Study of Suicide, Blackwood, NJ, USAAbstract: The aims of the present study were to examine clinical, personality, and sociodemographic predictors of suicide risk in a sample of inpatients affected by major affective disorders. The participants were 74 inpatients affected by major depressive disorder or bipolar disorder-I. Patients completed a semi-structured interview, the Beck Hopelessness Scale, the Aggression Questionnaire, the Barratt Impulsiveness Scale, and the Hamilton scales for depression and anxiety. Over 52% of the patients were high suicide risks. Those at risk reported more severe depressive-anxious symptomatology, more impulsivity and more hostility. Impulsivity, the use of antidepressants, anxiety/somatization, and the use of mood stabilizers (a negative predictor resulted in accurate predicting of suicide intent. Impulsivity and antidepressant use were the strongest predictors even after controlling for several sociodemographic and clinical variables.Keywords: suicide, mood disorders, pharmacotherapy, impulsiveness, aggressiveness

  9. Social cognition in Williams syndrome: face tuning

    Directory of Open Access Journals (Sweden)

    Marina A Pavlova

    2016-08-01

    Full Text Available Many neurological, neurodevelopmental, neuropsychiatric and psychosomatic disorders are characterized by impairments in visual social cognition, body language reading, and facial assessment of a social counterpart. Yet a wealth of research indicates that individuals with Williams syndrome exhibit remarkable concern for social stimuli and face fascination. Here individuals with Williams syndrome were presented with a set of Face-n-Food images composed of food ingredients and in different degree resembling a face (slightly bordering on the Giuseppe Arcimboldo style. The primary advantage of these images is that single components do not explicitly trigger face-specific processing, whereas in face images commonly used for investigating face perception (such as photographs or depictions, the mere occurrence of typical cues already implicates face presence. In a spontaneous recognition task, participants were shown a set of images in a predetermined order from the least to most resembling a face. Strikingly, individuals with Williams syndrome exhibited profound deficits in recognition of the Face-n-Food images as a face: they did not report seeing a face on the images, which typically developing controls effortlessly recognized as a face, and gave overall fewer face responses. This suggests atypical face tuning in Williams syndrome. The outcome is discussed in the light of a general pattern of social cognition in Williams syndrome and brain mechanisms underpinning face processing.

  10. 50 years ago...

    CERN Multimedia

    Laëtitia Pedroso

    2010-01-01

    After completing her university studies in Italy, where it was not all that rare to come across female physicists, Maria Fidecaro arrived at CERN in 1956. Although men were certainly in the majority, they were all just colleagues and gender was irrelevant.    Giuseppe and Maria Fidecaro in 1963, surrounded by spark chambers, inside the detector for the experiment on the decay of a rho meson into a pi meson and a photon. Maria Fidecaro is no stranger to CERN and the field of research, having watched them develop over many years. "In the early days we worked in small teams of no more than two or three people", she recalls. "As in Italy, I was not the only woman involved in research at CERN. Men and women alike, our common goal was to understand physics and conduct experiments." Clearly, juggling an exciting job and looking after a family of four children didn't make for an easy life. "At that time society was different and there were few cr&...

  11. 7 July 2011 - Members of the Swiss Federal Council (front row) in front of the Globe of Science and Innovation.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    CERN-HI-1107166 01 1er rang: La chancelière Corina Casanova, le conseiller fédéral Johann N. Schneider-Ammann, le conseiller fédéral Ueli Maurer, la conseillère fédérale Eveline Widmer-Schlumpf, la conseillère fédérale Simonetta Sommaruga, la Présidente de la Confédération Micheline Calmy-Rey, le Directeur général du CERN Rolf Heuer, la conseillère fédérale Doris Leuthard, le conseiller fédéral Didier Burkhalter. 2è rang: Le vice-chancelier André Simonazzi , le vice-chancelier Thomas Helbling, la chef des relations internationales Felicitas Pauss, le directeur de la recherche et du calcul scientifique Sergio Bertolucci. 3è rang: Les scientifiques suisses: Ulrich Straumann (LHCb, Zürich et délégué suisse au Conseil du CERN), Rainer Wallny (CMS, ETHZ), Günther Dissertori (CMS, ETHZ), Antonio Ereditato (ATLAS, Bern), Tatsuya Nakada (LHCb, EPFL), Olivier Schneider (LHCb, EPFL), Martin Pohl (ATLAS, Genève), Vincenzo Chiochia (CM, Zürich), Giuseppe Iacobucci (ATLAS, Genève), le C...

  12. Hidradenitis suppurativa: from pathogenesis to diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Napolitano M

    2017-04-01

    Full Text Available Maddalena Napolitano,1 Matteo Megna,2 Elena A Timoshchuk,3 Cataldo Patruno,2 Nicola Balato,2 Gabriella Fabbrocini,2 Giuseppe Monfrecola2 1Dipartimento di Medicina e Scienze della Salute “Vincenzo Tiberio”, Università degli Studi del Molise, Campobasso, 2Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; 3Department of Dermatovenereology, Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia Abstract: Hidradenitis suppurativa (HS is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body and presenting with painful nodules, abscesses, sinus tracts, and scarring. HS is a multifactorial disease in which genetic and environmental factors play a key role. The primary defect in HS pathophysiology involves follicular occlusion of the folliculopilosebaceous unit, followed by follicular rupture, and immune responses (perifollicular lympho-histiocytic inflammation, finally leading to the development of clinical HS lesions. HS has a destructive impact on the patient’s quality of life, being a very challenging disease. Available treatments are limited, mostly off-label and with high variability in the reported efficacy. Fortunately, a monoclonal antibody against tumor necrosis factor alpha has been recently approved for treatment of moderate to severe HS, offering patients a promising new option. This review focuses on the main features of HS, including epidemiology, clinical aspects, pathogenesis, severity classifications, comorbidities, and currently available treatments. Keywords: hidradenitis suppurativa, pathogenesis, diagnosis, treatment

  13. Safety and efficacy of alteplase in the treatment of acute ischemic stroke

    Directory of Open Access Journals (Sweden)

    Giuseppe Micieli

    2009-05-01

    Full Text Available Giuseppe Micieli, Simona Marcheselli, Piera Angela TosiNeurology and Stroke Unit, IRCCS Istituto Clinico Humanitas, Rozzano (MI, italyAbstract: After publication of the results of the National Institute of Neurological Disorders and Stroke study, the application of intravenous thrombolysis for ischemic stroke was launched and has now been in use for more than 10 years. The approval of this drug represented only the first step of the therapeutic approach to this pathology. Despite proven efficacy, concerns remain regarding the safety of recombinant tissue-type plasminogen activator for acute ischemic stroke used in routine clinical practice. As a result, a small proportion of patients are currently treated with thrombolytic drugs. Several factors explain this situation: a limited therapeutic window, insufficient public knowledge of the warning signs for stroke, the small number of centers able to administer thrombolysis on a 24-hour basis and an excessive fear of hemorrhagic complications. The aim of this review is to explore the clinical efficacy of treatment with alteplase and consider the hemorrhagic risks.Keywords: rt-PA, acute ischemic stroke, intracranial hemorrhage

  14. Almotriptan in the treatment of migraine

    Directory of Open Access Journals (Sweden)

    Giorgio Sandrini

    2007-01-01

    Full Text Available Giorgio Sandrini, Armando Perrotta, Natalia L Arce Leal, Simona Buscone, Giuseppe NappiUniversity Centre for Adaptive Disorders and Headache, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia, ItalyAbstract: Almotriptan is an orally administered, highly selective serotonin 5-HT(1B/1D receptor agonist that is effective in the acute treatment of moderate to severe migraine attacks. Since its introduction on to the market in 2001, several studies involving a large number of migraine patients have confirmed its efficacy and tolerability profile. Almotriptan, was found to be among the best-responding triptans in terms of pain relief and pain-free rate at 2 h. It has been reported that almotriptan has the best sustained pain-free (SPF rate and the lowest adverse events (AEs rate of all the triptans. When these clinical characteristics were combined to form the composite endpoint SPF and no AEs (SNAE, almotriptan emerged as the triptan with the best efficacy and tolerability profile. It also showed a good efficacy profile during the early treatment (within 1 h of onset of migraine attacks characterized by moderate pain intensity. On the basis of these findings, almotriptan may be considered a therapeutic option for the acute treatment of migraine attacks.Keywords: almotriptan, triptans, migraine, treatment

  15. Anti-TNF therapy for juvenile idiopathic arthritis-related uveitis

    Directory of Open Access Journals (Sweden)

    Semeraro F

    2014-03-01

    Full Text Available Francesco Semeraro,1 Barbara Arcidiacono,2 Giuseppe Nascimbeni,1 Martina Angi,1 Barbara Parolini,2 Ciro Costagliola31Eye Clinic, Department of Neurological Sciences and Vision, University of Brescia, Brescia, Italy; 2Department of Ophthalmology, S. Anna Hospital, Brescia, Italy; 3Eye Clinic, Department of Health Sciences, University of Molise, Campobasso, ItalyAbstract: Juvenile idiopathic arthritis-related uveitis is the most common type of uveitis in childhood and one of the main causes of visual impairment in children. The introduction of biological treatment has widened the range of therapeutic options for children with uveitis refractory to standard nonbiologic immunosuppressants. Data from clinical trials suggest that both adalimumab and infliximab have demonstrated effectiveness and safety in open-label studies, although no large, randomized, controlled trials have been reported so far. The role of etanercept in treating juvenile idiopathic arthritis-related uveitis is not yet well defined. In our experience, anti-tumor necrosis factor therapy has been shown to be more effective than steroids and/or methotrexate in treating uveitis. Up to now, tumor necrosis factor blocking compounds have been reserved for the treatment of the most severe cases of refractory uveitis, and larger prospective clinical trials are required in order to better assess the safety of these new compounds.Keywords: adalimumab, etanercept, infliximab

  16. Clinical utility of ivabradine in cardiovascular disease management: current status

    Directory of Open Access Journals (Sweden)

    Rosano GMC

    2014-08-01

    Full Text Available Giuseppe MC Rosano,1,2 Cristiana Vitale,1,2 Ilaria Spoletini,1 Maurizio Volterrani11Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy; 2Cardiovascular and Cell Sciences Research Institute, St George's University of London, London, UK Abstract: Ivabradine is a selective antagonist of the funny channels with anti-anginal and anti-ischemic properties, approved for the treatment of coronary artery disease (CAD and heart failure (HF. It provides pure heart rate reduction, reducing the diastolic depolarization slope, without altering hemodynamic parameters. This review summarizes the current knowledge on the efficacy of ivabradine in patients with cardiovascular diseases, with a particular focus on its role in the clinical management of patients with CAD and HF. There is consistent evidence that ivabradine is effective in reducing angina pectoris symptoms and myocardial ischemia. At approved doses ivabradine is safe, improves exercise tolerance, and reduces heart rate. Available data from clinical trials support its use in the management of patients with stable CAD and chronic HF. Recent studies have cast doubt on the safety of non-approved high doses of ivabradine for the treatment of patients with CAD and without clinical HF, but have shown no concerns on the doses approved for clinical use. Keywords: ivabradine, coronary artery disease, heart failure, angina pectoris, exercise performance

  17. Looking at our origins

    CERN Multimedia

    Nairucu Arts

    2011-01-01

    Exhibition by Nairucu-Arts, in collaboration with the Anthropology Museum Giuseppe Sergi, Università la Sapienza, Roma, Italy and ECOLINT, Campus des Nations. The exhibition comprises: posters (in English and French) intended for a large audience with text from Prof. Giorgio Manzi, Julia Rizzo, Fabio Di Vincenzo, illustrated with art drawings from Carlo Ranzi, Italy. The exhibition will also present drawings from the students of the Art Classes of Karin Bain and Fabien Bruttin at ECOLINT,Geneva. On 2nd March at 5 p.m. you will be welcomed with a drink before the conference that will be given in English at 6 p.m in the CERN Council Room by Wim De Geest, a retired Professor from KUB (Catholic University of Brussels). Title: There's no language like our language, like no language we know. But how did it evolve? A summary in French will be made available for the public. http://association.web.cern.ch/association/en/OtherActivities/Origins.html

  18. Ramucirumab: preclinical research and clinical development

    Directory of Open Access Journals (Sweden)

    Aprile G

    2014-10-01

    Full Text Available Giuseppe Aprile,1 Erika Rijavec,2 Caterina Fontanella,1 Karim Rihawi,1 Francesco Grossi21Department of Oncology, University Hospital of Udine, Udine, Italy; 2Lung Cancer Unit, National Cancer Institut “San Martino”, Genoa, ItalyAbstract: Ramucirumab (IMC-1121B, LY3009806, a fully humanized monoclonal antibody directed against the extracellular domain of vascular endothelial growth factor receptor 2 (VEGFR-2, is a new therapeutic option that selectively inhibits the human VEGFR-2 with a much greater affinity than its natural ligands. Based on the promising results of both preclinical and early clinical studies, ramucirumab has been tested in different tumor types either alone or in combination with chemotherapy. While it has recently been granted its first US Food and Drug Administration approval for use as a single agent in patients with advanced or metastatic gastric cancer or gastroesophageal junction carcinoma, its role for metastatic breast cancer or advanced non-small-cell lung cancer is still debated. The aims of this review are to recall and discuss the most significant preclinical and clinical studies that led to the development of ramucirumab and to present the results of the randomized clinical trials that have tested its efficacy in different malignancies, including gastric and lung cancer. Keywords: ramucirumab, gastric cancer, lung cancer, breast cancer, antiangiogenic

  19. A phosphatidylcholine hyaluronic acid chitin–nanofibrils complex for a fast skin remodeling and a rejuvenating look

    Directory of Open Access Journals (Sweden)

    Morganti P

    2012-12-01

    Full Text Available Pierfrancesco Morganti,1 Paolo Palombo,2 Marco Palombo,3 Giuseppe Fabrizi,4 Antonio Cardillo,5 Fabiano Svolacchia,5 Luis Guevara,6 Paolo Mezzana71Department of Applied Cosmetic Dermatology, University of Naples Federico II, Naples, Italy; 2Department of Plastic, Reconstructive and Aesthetic Surgery, Saint Eugenio Hospital, Rome, Italy; 3Department of Plastic, Reconstructive and Aesthetic Surgery, CTO Hospital, Rome, Italy; 4Department of Dermatology, University of Parma, Parma, Italy; 5Centre of Nanoscience, Mavi Sud, Aprilia, Italy; 6Hospimedical, Pyrmont, Australia; 7IRCCS GB Bietti Eye Foundation, Rome, ItalyBackground: The reduction of mortality worldwide has led older individuals to seek intervention modalities to improve their appearance and reverse signs of aging.Objective: We formulated a medical device as innovative block-polymer nanoparticles based on phosphatidylcholine, hyaluronan, and chitin nanofibrils entrapping amino acids, vitamins, and melatonin.Methods: Viability and collagen synthesis were controlled on fibroblasts ex vivo culture while adenosine triphosphate production was evaluated on keratinocytes culture. Subjective and objective evaluations were performed in vivo on selected volunteer patients.Results: In accordance with our previous studies, both the in vitro and in vivo obtained results demonstrate the efficacy of the injected block-polymer nanoparticles in reducing skin wrinkling and ameliorating the signs of aging.Keywords: antiaging agent, scar correction, stretch marks, signaling molecules, photoaging, biostimulation

  20. Guido Vegni (1931 - 2016)

    CERN Multimedia

    2016-01-01

    Guido Vegni, a renowned particle physicist and Professor at the University of Milan, passed away on Thursday, 2 June.   Professor Guido Vegni in 1976, at the Institute for High Energy Physics in Protvino, Russia. Italian physicist Guido Vegni passed away on Thursday, 2 June. With his death we have lost a friend, an excellent physicist and a strong supporter of the CERN programme. His long and fruitful involvement in particle physics started in the mid 1950s, when he joined the Milan nuclear emulsion group led by Giuseppe Occhialini in 1956. His thesis aimed to measure the spin-parity assignment of the K+ meson from its decay into three pions, contributing to the study of the famous "tau-theta puzzle", eventually solved by the discovery of the non-conservation of parity in weak interactions. In 1960, Guido was appointed "Assistant" to Professor G. Occhialini in Milan, the first step of a career that led to him eventually becom...

  1. Improvement of gross motor and cognitive abilities by an exercise training program: three case reports

    Directory of Open Access Journals (Sweden)

    Alesi M

    2014-03-01

    Full Text Available Marianna Alesi,1 Giuseppe Battaglia,2 Michele Roccella,1 Davide Testa,1 Antonio Palma,2 Annamaria Pepi1 1Department of Psychology, 2Department of Law, Social and Sport Science, University of Palermo, Palermo, Italy Background: This work examined the efficacy of an integrated exercise training program (coach and family in three children with Down syndrome to improve their motor and cognitive abilities, in particular reaction time and working memory. Methods: The integrated exercise training program was used in three children with Down syndrome, comprising two boys (M1, with a chronological age of 10.3 years and a mental age of 4.7 years; M2, with a chronological age of 14.6 years and a mental age of less than 4 years and one girl (F1, chronological age 14.0 years and a mental age of less than 4 years. Results: Improvements in gross motor ability scores were seen after the training period. Greater improvements in task reaction time were noted for both evaluation parameters, ie, time and omissions. Conclusion: There is a close interrelationship between motor and cognitive domains in individuals with atypical development. There is a need to plan intervention programs based on the simultaneous involvement of child and parents and aimed at promoting an active lifestyle in individuals with Down syndrome. Keywords: disability, Down syndrome, gross motor abilities, cognitive abilities, physical activity

  2. The origins of psychology in Italy: Themes and authors that emerge through a content analysis of the Rivista di Filosofia Scientifica [Journal of Scientific Philosophy].

    Science.gov (United States)

    Bartolucci, Chiara; Lombardo, Giovanni Pietro

    2012-08-01

    This article examines the scientific-cultural context of the second half of the 1800s, during which psychological science emerged in Italy. The article explores the contribution made by the emergence of the primary research traditions of that period, namely, physiological anthropology and phreniatry, by means of a methodology that combines content analysis with a classical historiographical study of the period. Themes and authors deriving from the various disciplines in the human and natural sciences were identified through a content analysis of the Rivista di Filosofia Scientifica [Journal of Scientific Philosophy], a periodical that is representative of Italian positivism. The analysis highlights the epistemological perspective held by scholars who, distancing themselves from the mechanistic reductionism of the proponents of positivism, integrated a naturalistic and evolutionary conceptualization with the neo-Kantian critique. A clearly delineated naturalistic and differential perspective of scientific research that brought about the birth of psychology as an experimental discipline in Italy in the 1900s emerges from the analysis, including psychology and psychopathology as studied by the phreniatrists Gabriele Buccola, Enrico Morselli, and Eugenio Tanzi; Tito Vignoli and Giuseppe Sergi's work in comparative anthropology; Giulio Fano's approach and contribution to physiology; and Enrico Ferri's contribution to criminology. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  3. PREFACE: 5th International Workshop on Top Quark Physics (TOP2012)

    Science.gov (United States)

    Salamanna, G.; Boisvert, V.; Cerrito, L.; Khan, A.; Moretti, S.; Owen, M.; Schwanenberger, C.

    2013-07-01

    resonances in the boosted top regime were also provided. Finally, a set of dedicated talks on the interplay between the top sector and other hot subjects, like the Higgs and SUSY, were given both at the theory and experimental level. Furthermore, ad hoc student sessions were organized to allow younger colleagues to pose questions to the senior experts in the field and contribute with their more recent studies. The conference has been a definitive success, not just scientifically: about 130 participants from all over the world created a collegiate spirit which culminated in the social events at Winchester Hall below King Arthur's table; and in a cosy 16th century barn for the social dinner. The Local Organizing Committee would like to thank all participants, and in particular the speakers, for their high level contributions to TOP 2012 and for making this a very fruitful and pleasant time together. We conclude by wishing the Organizing Committee of TOP 2013 all the best for a successful conference. We look forward to seeing everyone in Germany in 2013. Giuseppe Salamanna Local Organizing Committee London, June 2013 Local Organising Committee Veronique Boisvert (Chair, Royal Holloway, University of London) Lucio Cerrito (Queen Mary, University of London) Akram Khan (Brunel University, London) Stefano Moretti (University of Southampton) Mark Owen (University of Manchester) Giuseppe Salamanna (Queen Mary, University of London) Christian Schwanenberger (University of Manchester) International Advisory Committee Roberto Tenchini (INFN, Pisa) Martine Bosman (IFAE, Barcelona) Michelangelo Mangano (CERN) Scott Willenbrock (University of Illinois, Urbana) Werner Bernreuther (RWTH, Aachen) Jorgen D'Hondt (VUB, Brussels) Antonio Onofre (LIP, University Minho) Fabio Maltoni (UCL, Louvain) Eric Laenen (NIKHEF) Fabrizio Margaroli (INFN, Roma 1) Juan Antonio Aguilar Saavedra (University of Granada) Yvonne Peters (University of Manchester) Roberto Chierici (CERN) Markus Cristinziani

  4. PREFACE: International Conference "Trends in Spintronics and Nanomagnetism" (TSN-2010)

    Science.gov (United States)

    Maruccio, Giuseppe; Sanvito, Stefano; Hoffmann, Germar; Wiesendanger, Roland; Rowan, Alan

    2011-03-01

    Conference banner The International Conference "Trends in Spintronics and Nanomagnetism" (TSN-2010), was organized by partners of the EU-project SpiDME and held in the historical city of Lecce, Italy from 23-27 May 2010, at the Ecotekne Campus, University of Salento. The conference provided an international forum to discuss recent progress and future trends in the field. In particular, the aim was to bring together the community of more conventional spin-transport, with that of molecular and nano-magnetism. The main topics of TSN-2010 were: MATERIALSSPIN-PHYSICS AND THEORY - Molecular Magnets- Spin injection - Magnetic nanoparticles and nanowires- Domain walls, spin torque and vortex dynamics - Magnetic semiconductors- Numerical modeling of organic nanomagnetism - Multiferroics and transition metal oxides APPLICATIONSADVANCES IN CHARACTERIZATION - Magnetic Multilayers- Magneto-optical characterization and spin manipulation - Spin-photonics- Intrinsic spin transport mechanism in organics - Molecular and nano-spintronics- Organometallic molecules on surfaces - Spin-based quantum computation- Single molecular magnets on surfaces - Magnetism for sensing and nanomedicine- Nanoscale characterization and spin-sensitive SPM The scientific programme started on Monday 24 May and ended on Thursday 27 May. The Nobel Laureate A Fert attended the conference giving a plenary talk and the programme also featured invited presentations by (in alphabetical order): M Aeschlimann, M Affronte, N Atodiresei, P A Bobbert, A Dediu, N Kioussis, L W Molenkamp, J Moodera, V Prigodin, M Ruben, R Sessoli, R Tan, and H Wende. TSN2010 had 150 attendees who came from around the globe to present their latest research in 100 oral presentations. Contributed talks were selected by the program committee, composed of Giuseppe Maruccio, Ross Rinaldi, Valentina Arima, Fabio Della Sala, Maurizio Martino (Universitá del Salento, NNL Institute Nanoscience-CNR, Lecce, Italy), Stefano Sanvito (Trinity College

  5. The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs

    Directory of Open Access Journals (Sweden)

    Serra R

    2014-05-01

    Full Text Available Raffaele Serra,1,2,* Luca Gallelli,3,* Angela Conti,1 Giovanni De Caridi,4 Mafalda Massara,4 Francesco Spinelli,4 Gianluca Buffone,1 Francesco Giuseppe Caliò,5 Bruno Amato,6 Simona Ceglia,7 Giuseppe Spaziano,8 Luca Scaramuzzino,9 Alessia Giovanna Ferrarese,10 Raffaele Grande,1 Stefano de Franciscis1,2 1Interuniversity Center of Phlebolymphology (CIFL, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy; 2Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy; 3Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy; 4Cardiovascular and Thoracic Department, University of Messina, Messina, Italy; 5Unit of Vascular Surgery, S Anna Hospital, Catanzaro, Italy; 6Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; 7Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy; 8Department of Experimental Medicine, Second University of Naples, Naples, Italy; 9University Campus BioMedico of Rome, Rome, Italy; 10Department of General Surgery, University of Turin, Turin, Italy *These authors contributed equally to this work Background: Mixed venous and arterial ulcers account for approximately 15%–30% of all venous leg ulcerations. Several studies have shown that matrix metalloproteinases (MMPs and neutrophil gelatinase-associated lipocalin (NGAL play a central role in the pathophysiology of venous and arterial diseases. Some studies have shown the efficacy of glycosaminoglycans, such as sulodexide (SDX, in treating patients with leg ulcers. The aim of this study was to evaluate clinical effects of SDX and its correlation with MMPs and NGAL expression in patients with mixed arterial and venous leg ulcers. Methods: Patients eligible for this study were of both sexes, older than 20 years, and with a

  6. Letteratura tecnica e formazione degli architetti ai tempi di Antonio Mollari

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    Alessandro Gambuti

    2014-04-01

    Full Text Available Nel corso del Settecento, nella letteratura tecnica, a seguito della critica razionalista del pensiero illuminista, cominciano a comparire principî scientifici per migliorare la formazione degli architetti. Nel 1764 Girolamo Fonda, matematico, pubblica gli Elementi di Architettura civile e militare e dedica la prima parte alla “Sodezza delle fabbriche”, premettendo le regole costruttive alla convenienza e all’estetica. Francesco Milizia avvia i Principj di Architettura civile (1781 con i temi della bellezza e della comodità, ma, nella terza parte, tratta della solidità con citazioni di meccanica, fisica e ingegneria. Qualche anno dopo (1788, Girolamo Masi stampa, per la “gioventù romana”, Teoria e Pratica dell’Architettura civile; seguendo il metodo del Fonda e continuando l’opera del Milizia egli propone nozioni sui materiali e sulle “resistenze” con il sussidio di illustrazioni e tabelle. Nel 1772 era stato ristampato il Manuale… di Giovanni Branca con la revisione di Leonardo de Vegni, dilettante di architettura; una notevole utilità didattica apportarono le incisioni di Giovan Battista Cipriani, allegate ai Principj… del Milizia (1800 e le Osservazioni ed aggiunte di Giovanni Antonio Antolini alla stessa opera (1817. All’inizio dell’Ottocento, l’Architettura pratica di Giuseppe Valadier dette un incremento alla formazione professionale degli architetti per mezzo di lezioni teoriche e disegni di procedimenti ed attrezzature per i costruttori di edifici. During the XVIIIth century, in the technical treatises, owing to the rationalist criticism of the Enlightenment movement, scientific principles begin to appear in order to improve the education of the architects. In 1764 Girolamo Fonda, a mathematician, publishes Elementi di Architettura civile e militare and gives up the first part to the “Solidity of Buildings”, putting before the construction rules to the convenience and beauty. Francesco Milizia opens

  7. Lorenzo Lotto e gli strumenti del mestiere: la periferia come consapevole scelta strategica / Lorenzo Lotto and the tools of the trade: the periphery as a conscious strategic choice

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    David Frapiccini

    2014-06-01

    Full Text Available Con il testamento del 25 marzo 1531 Lorenzo Lotto stabiliva la ripartizione dei modelli in gesso e in cera e dei propri disegni tra tre suoi antichi allievi: il bergamasco Francesco Bonetti, il veneziano Pietro di Giovanni – in quel momento attivo a Ragusa, l’odierna Dubrovnik – e il marchigiano maestro Giulio da Amandola, identificabile con Giulio Vergari. Dalle provenienze dei tre artefici si manifesta una chiara mappa geografica, come se Lotto avesse consapevolmente deciso di lasciare i ferri del mestiere nei luoghi della sua esperienza pittorica: a Bergamo, a Venezia e nelle Marche. Contemporaneamente Lotto frequenta i pittori Alessandro Oliverio, Bonifacio de’ Pitati da Verona e Girolamo da Santa Croce: il secondo, stando alle disposizioni testamentarie, avrebbe dovuto completare le opere rimaste incompiute alla morte di Lotto, mentre al terzo sarebbero andati alcuni strumenti della professione a beneficio dei propri figli. Si viene così a delineare un gruppo di artisti marginale rispetto al contesto lagunare, ma orientato verso committenze di entroterra o di area adriatica. La consapevolezza acquisita da Lotto nell’incidenza territoriale della sua attività spiega la ragione delle reminiscenze iconografiche e formali bergamasche in parte della produzione risalente agli estremi anni marchigiani (1549-1556, ovvero a quella fase inaugurata con l’Assunzione anconetana di San Francesco alle Scale, pala realizzata nel 1549-1550 con la collaborazione di Giuseppe Belli da Ponteranica. With the will of March 25, 1531 Lorenzo Lotto established the distribution of models in plaster and wax and their designs to three of his former pupils: Francesco Bonetti from Bergamo, the Venetian Pietro di Giovanni – at that time active in Ragusa, today's Dubrovnik – and maestro Giulio from Amandola identified with Giulio Vergari. The origins of the three painters manifest a clear geographical map, as if Lotto had consciously decided to leave the

  8. Ontological Encoding of GeoSciML and INSPIRE geological standard vocabularies and schemas: application to geological mapping

    Science.gov (United States)

    Lombardo, Vincenzo; Piana, Fabrizio; Mimmo, Dario; Fubelli, Giandomenico; Giardino, Marco

    2016-04-01

    SimpleLithology CGI vocabulary and aligned as a subclass of the Substance class in NASA SWEET ontology), and 3) an ontology of the MappedFeatures (as defined in the Representation sub-taxonomy of the NASA SWEET ontology). The latter correspond to the concrete elements of the map, with their geometry (polygons, lines) and geographical coordinates. The ontology model has been developed by taking into account applications primarily concerning the needs of geological mapping; nevertheless, the model is general enough to be applied to other contexts. In particular, we show how the automatic reasoning capabilities of the ontology system can be employed in tasks of unit definition and input filling of the map database and for supporting geologists in thematic re-classification of the map instances (e.g. for coloring tasks). ---------------------------------------- [1] http://www.geosciml.org [2] http://inspire.jrc.ec.europa.eu/documents/Data_Specifications/INSPIRE_DataSpecification_GE_v3.0rc3.pdf [3] http://www.cgi-iugs.org/tech_collaboration/geoscience_terminology_working_group.html [4] https://www.seegrid.csiro.au/subversion/CGI_CDTGVocabulary/trunk/OwlWork/CGI_Lithology.owl [5] We are currently neglecting the encoding of the geologic events, left as a future work. [6] http://resource.geosciml.org/vocabulary/cgi/201211/ [7] Web site: https://sweet.jpl.nasa.gov, Di Giuseppe et al., 2013, SWEET ontology coverage for earth system sciences, http://www.ics.uci.edu/~ndigiuse/Nicholas_DiGiuseppe/Research_files/digiuseppe14.pdf; S. Barahmand et al. 2009, A Survey on SWEET Ontologies and their Applications, http://www-scf.usc.edu/~taheriya/reports/csci586-report.pdf

  9. Next-generation drug-eluting stents in coronary artery disease: focus on everolimus-eluting stent (Xience V®

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    Imad Sheiban

    2008-02-01

    Full Text Available Imad Sheiban1, Gianluca Villata1, Mario Bollati1, Dario Sillano1, Marzia Lotrionte2, Giuseppe Biondi-Zoccai11Interventional Cardiology, Division of Cardiology, University of Turin, Turin, Italy; 2Institute of Cardiology, Catholic University, Rome, ItalyAbstract: Percutaneous coronary revascularization has been a mainstay in the management of coronary artery disease since its introduction in the late 1970s. Bare-metal stents and, more recently, first-generation drug-eluting stents (DES, such as sirolimus-eluting (Cypher® and paclitaxel-eluting stents (Taxus®, have further improved results of percutaneous coronary intervention (PCI by improving early results and reducing the risk of restenosis. There is currently debate on the safety of these first-generation DES, given the potential for late stent thrombosis, especially after discontinuation of dual antiplatelet therapy. There are well known caveats on the performance of their respective metallic stent platforms, delivery, and dilation systems, and polymer coatings. Second-generation DES, such as zotarolimus-eluting (Endeavor® and everolimus-eluting stents (Xience V®, have recently become available in the USA and/or Europe. The Xience V stent holds the promise of superior anti-restenotic efficacy as well as long-term safety. In addition, this stent is based on the Multi-link platform and delivery system. Recently available data already suggest the superiority of the Xience V stent in comparison to the Taxus stent in terms of prevention of restenosis, without significant untoward events. Nonetheless, the number of patients studied and the follow-up duration are still too limited to enable definitive conclusions. Only indirect meta-analyses can be used to date to compare the Xience V with the Cypher. This systematic review tries to provide a concise and critical appraisal of the data in support of the Xience V everolimus-eluting stent.Keywords: coronary artery disease, everolimus, percutaneous

  10. Gradenigo Syndrome: Unusual Consequence of Otitis Media

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    Jennie M. Valles

    2014-07-01

    Full Text Available Introduction: In 1904, Giuseppe Gradenigo published his case series on the triad of ipsilateral abducens nerve palsy, facial pain in the trigeminal nerve distribution, and suppurative otitis media, which would subsequently be referred to as Gradenigo syndrome. Case Report: Our patient was a 36-year-old female, 23 weeks pregnant, with a 6-day history of right-sided otalgia and hearing loss and a 4-day history of purulent otorrhea, who presented with severe, holocephalic headache, meningeal signs, fever, photophobia, and mental status decline. Lumbar puncture yielded a white blood cell count of 1,559 cells/mm3 with 95% polymorphonuclear leukocytes, a red blood cell count of 111 cells/mm3, a protein level of 61 mg/dl, and a glucose level of Streptococcus pneumoniae and treated with ceftriaxone. On the second hospital day, she developed horizontal diplopia due to right abducens nerve palsy and right mydriasis. Both symptoms resolved on the third hospital day. Erosion of temporal bone and opacification of mastoid air cells was shown on CT scan. A CT venogram showed an irregularity of the left transverse and superior sagittal sinuses. She was treated with enoxaparin for possible sinus thrombosis. Discussion: This case demonstrates rare but serious sequelae of otitis media and Gradenigo syndrome. Holocephalic headache from meningitis masked trigeminal pain. Involvement of the ipsilateral petrous apex and surrounding structures on imaging and clinical improvement with antibiotic treatment supports Gradenigo syndrome over intracranial hypertension due to venous sinus thrombosis as the cause of the abducens nerve palsy.

  11. Managing diabetic patients with moderate or severe renal impairment using DPP-4 inhibitors: focus on vildagliptin

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    Russo E

    2013-04-01

    Full Text Available Eleonora Russo, Giuseppe Penno, Stefano Del Prato Department of Clinical and Experimental Medicine, Section of Diabetes and Metabolic Disease, Azienda Ospedaliero Universitaria di Pisa, and University of Pisa, Pisa, Italy Background: Dipeptidyl peptidase-4 (DPP-4 inhibitors are novel classified oral anti-diabetic drugs for the treatment of type 2 diabetes mellitus (T2DM that provide important reduction in glycated hemoglobin, with a low risk for hypoglycemia and no weight gain. In T2DM patients with reduced renal function, adequate glycemic control is essential to delay the progress of kidney dysfunction, but they are at a greater risk of experiencing hypoglycemic events, especially with longer-acting sulfonylureas and meglitinides. Objective: To evaluate vildagliptin as an option to achieve glycemic control in T2DM patients with moderate or severe chronic kidney disease (CKD. Methods: A comprehensive search in the literature was performed using the term "vildagliptin." Original articles and reviews exploring our topic were carefully selected. Results: Vildagliptin provides effective glycemic control in patients with T2DM and CKD. Dose reductions are required for vildagliptin and other DPP-4 inhibitors, except linagliptin, in T2DM patients with moderate-to-severe CKD. Dose of vildagliptin had to be reduced by half (to 50 mg/day both for moderate (estimated glomerular filtration rate [eGFR] ≥30 to ≤50 mL/min and severe CKD (eGFR < 30 mL/min. Available results support a favorable efficacy, safety, and tolerability profile for vildagliptin in T2DM with moderate or severe renal failure. Preliminary data may suggest additional benefits beyond improvement of glycemic control. Conclusion: Vildagliptin can be safely used in T2DM patients with varying degrees of renal impairment. Dose adjustments for renal impairment are required. Potential long-term renal benefit of vildagliptin needs to be further explored. Keywords: type 2 diabetes mellitus, renal

  12. The use of melatonin for treating sleep disorders in patients with Parkinson's disease

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    Srinivasan V

    2014-08-01

    Full Text Available Venkataramanujam Srinivasan,1 Domenico De Berardis,2,3 Timo Partonen,4 Rahimah Zakaria,5 Zahiruddin Othman6 1Sri Sathya Sai Medical Educational and Research Foundation, Coimbatore, India; 2Psychiatric Service of Diagnosis and Treatment, Giuseppe Mazzini Hospital, Teramo, 3Department of Neuroscience and Imaging, Gabriele d'Annunzio University, Chieti, Italy; 4Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland; 5Department of Physiology, 6Department of Psychiatry, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia Abstract: Most patients with Parkinson's disease (PD experience sleep-related problems, such as difficulty in initiating and maintaining sleep, excessive daytime sleepiness, sleep fragmentation, reductions in non-rapid eye movement (NREM or rapid eye movement (REM sleep, and REM sleep behavior disorder. Although motor symptoms of PD are treated with dopaminergic drugs, the nonmotor symptoms pose a big problem, and they often precede the onset of the disease. Treating the nonmotor symptoms, such as sleep and associated behavioral disorders, is beneficial, for it not only relieves the symptoms but also helps to slow the progression of the disease. Treating PD patients with melatonin has been shown to be beneficial in treating sleep and behavior problems. The finding of reduced expression of the MT1 and MT2 melatonin receptors in amygdalae and substantia nigra of PD patients supports the involvement of melatonergic system in the etiology of PD. Hence, the use of melatonin or its analogs may even be beneficial not only for improving sleep quality but also for enhancing neuroprotection in PD. Keywords: REM sleep-behavior disorder, insomnia, melatonin receptors, circadian dysregulation

  13. The melatonergic system: effects on sleep and implications for the treatment of psychiatric disorders

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    De Berardis D

    2011-12-01

    Full Text Available Domenico De Berardis1,2, Tiziano Acciavatti1, Giuseppe Di Iorio1, Mariangela Corbo1, Nicola Serroni2, Daniela Campanella2, Fabiola Di Emidio2, Monica Piersanti3, Marilde Cavuto4, Giovanni Martinotti5, Francesco Saverio Moschetta2, Massimo Di Giannantonio11Department of Neurosciences and Imaging, Chair of Psychiatry, University “G. D'Annunzio”, Chieti; 2NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini”; 3NHS, Pharmaceutical Service, Hospital “G. Mazzini”, Teramo; 4IASM, L'Aquila; 5Institute of Psychiatry, Catholic University Medical School, Rome, ItalyAbstract: The circadian pacemaker or biological clock, located in the hypothalamic suprachiasmatic nucleus, is the generation site of circadian rhythms. The light/dark cycle is the circadian pacemaker's dominant synchronizing agent, though it is also influenced by neurotransmitters and the phase-shifting effects of various chemical and pharmacological components, of which melatonin (N-acetyl-5-methoxytryptamine is the most well established. In recent years, melatonin and melatonin analogs have been commercialized in many countries, mainly with hypnotic purposes. A new compound, agomelatine, has been recently synthesized and studied. Among melatonin analogs, this drug possesses unique pharmacological and clinical features; it is an antagonist at 5-HT2B and 5-HT2C receptors and has well established antidepressant and anxiolytic properties. Agomelatine opens new perspectives in the chronobiotic treatment of depression. The purpose of the present review was to elucidate the effects of the melatonergic system on sleep and the implications for the treatment of psychiatric disorders.Keywords: melatonin, agomelatine, circadian rhythms, depression

  14. Language, visuality, and the body. On the return of discourse in contemporary performance

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    Vangelis Athanassopoulos

    2013-12-01

    Full Text Available This article deals with the return of discourse in experimental performance-based artistic practices. By putting this return in a historical perspective, we wish to address the questions it raises on the relation between language, image, and the body, resituating the avant-garde heritage in a contemporary context where intermediality and transdisciplinarity tend to become the norm rather than the exception. The discussion of the status and function of discourse in this context calls on the field of theatre and its ambivalent role in modern aesthetics, both as a specifically determined artistic discipline, and as a blending of heterogeneous elements, which defy the assigned limitations of creative practice. The confrontation of Antonin Artaud's writings with Michael Fried's conception of theatricality aims to bring to the fore the cultural transformations and historical paradoxes which inform the shift from theatre to performance as an experimental field situated “between” the arts and embracing a wide range of practices, from visual arts to music and dance. The case of lecture-performance enables us to call attention to the internal contradictions of the “educational” interpretation of such experimental practices and their autonomization inside the limits of a specific artistic genre. The main argument is that, despite the plurality of its origins and its claims to intermediality and transdisciplinarity, lecture-performance as a genre is attracted by or gravitates around the extended field of the visual arts. By focusing on the work of Jerôme Bel, Noé Soulier, Giuseppe Chico, Barbara Matijevic, and Carole Douillard, we stress some of the ways contemporary discursive strategies enable to displace visual spectacle toward a conception of the body as the limit of signification.

  15. Labeling and exocytosis of secretory compartments in RBL mastocytes by polystyrene and mesoporous silica nanoparticles

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    Ekkapongpisit M

    2012-04-01

    Full Text Available Maneerat Ekkapongpisit1,*, Antonino Giovia1,*, Giuseppina Nicotra1, Matteo Ozzano1, Giuseppe Caputo2,3, Ciro Isidoro1 1Laboratory of Molecular Pathology and Nanobioimaging, Department of Health Sciences, Università del Piemonte Orientale "A. Avogadro", Novara, Italy; 2Department of Chemistry, University of Turin, Turin, 3Cyanine Technology SpA, Torino, Italy *These authors contributed equally to this workBackground: For a safe ‘in vivo’ biomedical utilization of nanoparticles, it is essential to assess not only biocompatibility, but also the potential to trigger unwanted side effects at both cellular and tissue levels. Mastocytes (cells having secretory granules containing cytokines, vasoactive amine, and proteases play a pivotal role in the immune and inflammatory responses against exogenous toxins. Mastocytes are also recruited in the tumor stroma and are involved in tumor vascularization and growth.Aim and methods: In this work, mastocyte-like rat basophilic leukemia (RBL cells were used to investigate whether carboxyl-modified 30 nm polystyrene (PS nanoparticles (NPs and naked mesoporous silica (MPS 10 nm NPs are able to label the secretory inflammatory granules, and possibly induce exocytosis of these granules. Uptake, cellular retention and localization of fluorescent NPs were analyzed by cytofluorometry and microscope imaging.Results: Our findings were that: (1 secretory granules of mastocytes are accessible by NPs via endocytosis; (2 PS and MPS silica NPs label two distinct subpopulations of inflammatory granules in RBL mastocytes; and (3 PS NPs induce calcium-dependent exocytosis of inflammatory granules.Conclusion: These findings highlight the value of NPs for live imaging of inflammatory processes, and also have important implications for the clinical use of PS-based NPs, due to their potential to trigger the unwanted activation of mastocytes.Keywords: secretory lysosomes, inflammation, nanoparticles, vesicular traffic

  16. Red wine and cardiovascular health the "French Paradox" revisited

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    Giuseppe Lippi

    2010-01-01

    Full Text Available Giuseppe Lippi1, Massimo Franchini2, Gian Cesare Guidi31U.O. di Diagnostica Ematochimica, 2Servizio di Immunoematologia e Trasfusione, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero, Universitaria di Parma, Parma, Italy; 3Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Verona, ItalyAbstract: The healthful and nutritive properties of wine have been acknowledged for thousands of years, but the observation that moderate consumption of red wine on a regular basis may be preventative against coronary disease is recent. Dr Renaud, a scientist working at the Bordeaux University in France, suggested wine consumption explains the “French Paradox”, the low incidence of heart attacks in France regardless of a remarkable dietary intake of saturated fats and alcohol. After nearly 20 years of research, there is now mounting evidence that light to moderate wine intake is beneficial for the cardiovascular health, acting through a variety of mechanisms that target all the crucial steps of atherosclerosis, from early formation of the atherosclerotic plaque to its life-threatening complications (ulceration, thrombosis, vessel occlusion and infarction. These effects are attributable to the synergic properties of several biochemical components of wine (alcohol, resveratrol, and especially polyphenolic compounds, particularly the red varieties. This article reviews the leading clinical observations and the hypothesized biological mechanisms that strongly support the cardiovascular benefits of moderate red wine consumption on cardiovascular health and that would make red wine a promising therapeutic supplement to prevent and even perhaps treat coronary artery disease.Keywords: wine, cardiovascular disease, coronary disease, atherosclerosis

  17. PhD Dissertations

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    Redazione Reti Medievali (a cura di

    2005-12-01

    Tra Riforma, vescovo e clientes. Camaldoli e le società locali (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 [09/05] Giuseppe Gardoni "Episcopus et potestas". Vescovi e società a Mantova nella prima metà del Duecento, Tesi di dottorato di ricerca in Storia del Cristianesimo e delle Chiese (antichità, medioevo, età moderna, Università degli Studi di Padova, 2005 Nicola Mancassola La gestione delle campagne tra Langobardia e Romània in età carolingia e post carolingia. La struttura delle aziende fondiarie in Emilia e Romagna, Tesi di dottorato in Storia Medievale, Università degli Studi di Bologna, 2005 Gloria Papaccio Storia e archeologia degli opifici idraulici in Val di Pesa. La Badia di Passignano e i suoi mulini (XI-XIV secolo, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Adelaide Ricci La città e il suo ospedale: assetti urbani, dinamiche sociali e organizzazione del sistema caritativo-assistenziale a Cremona nel XV secolo, Tesi di dottorato di ricerca in Storia Medievale, Università degli studi di Torino, 2005 Luca Sant'Ambrogio Il borgo di Treviglio nel secondo Quattrocento: istituzioni e società, Tesi di dottorato di ricerca in Storia Medievale, Università degli Studi di Milano, 2005 Elisabetta Scarton Giovanni Lanfredini. Uomo d'affari e diplomatico nell'Italia del Quattrocento, Tesi di dottorato in Storia della società europea, Università degli Studi di Napoli "Federico II", 2005

  18. Diabetes and sexual dysfunction: current perspectives

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    Maiorino MI

    2014-03-01

    Full Text Available Maria Ida Maiorino,1 Giuseppe Bellastella,1 Katherine Esposito2 1Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Naples, Italy; 2Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy Abstract: Diabetes mellitus is one of the most common chronic diseases in nearly all countries. It has been associated with sexual dysfunction, both in males and in females. Diabetes is an established risk factor for sexual dysfunction in men, as a threefold increased risk of erectile dysfunction was documented in diabetic men, as compared with nondiabetic men. Among women, evidence regarding the association between diabetes and sexual dysfunction are less conclusive, although most studies have reported a higher prevalence of female sexual dysfunction in diabetic women as compared with nondiabetic women. Female sexual function appears to be more related to social and psychological components than to the physiological consequence of diabetes. Hyperglycemia, which is a main determinant of vascular and microvascular diabetic complications, may participate in the pathogenetic mechanisms of sexual dysfunction in diabetes. Moreover, diabetic people may present several clinical conditions, including hypertension, overweight and obesity, metabolic syndrome, cigarette smoking, and atherogenic dyslipidemia, which are themselves risk factors for sexual dysfunction, both in men and in women. The adoption of healthy lifestyles may reduce insulin resistance, endothelial dysfunction, and oxidative stress – all of which are desirable achievements in diabetic patients. Improved well-being may further contribute to reduce and prevent sexual dysfunction in both sexes. Keywords: diabetes mellitus, diabetes complications, erectile dysfunction, female sexual dysfunction, lifestyle changes

  19. Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5

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    Viggiano E

    2016-07-01

    Full Text Available Emanuela Viggiano,1,2 Vincenzo Monda,1 Antonietta Messina,1 Fiorenzo Moscatelli,3 Anna Valenzano,3 Domenico Tafuri,4 Giuseppe Cibelli,3 Bruno De Luca,1 Giovanni Messina,1,3 Marcellino Monda1 1Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Second University of Naples, Naples, 2Department of Medicine, University of Padua, Padua, 3Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 4Department of Motor Sciences and Wellness, University of Naples “Parthenope”, Naples, Italy Abstract: Depression of electrocorticogram propagating over the cortex surface results in cortical spreading depression (CSD, which is probably related to the pathophysiology of stroke, epilepsy, and migraine. However, preconditioning with CSD produces neuroprotection to subsequent ischemic episodes. Such effects require the expression or activation of several genes, including neuroprotective ones. Recently, it has been demonstrated that the expression of the uncoupling proteins (UCPs 2 and 5 is amplified during brain ischemia and their expression exerts a long-term effect upon neuron protection. To evaluate the neuroprotective consequence of CSD, the expression of UCP-5 in the brain cortex was measured following CSD induction. CSD was evoked in four samples of rats, which were sacrificed after 2 hours, 4 hours, 6 hours, and 24 hours. Western blot analyses were carried out to measure UCP-5 concentrations in the prefrontal cortices of both hemispheres, and immunohistochemistry was performed to determine the localization of UCP-5 in the brain cortex. The results showed a significant elevation in UCP-5 expression at 24 hours in all cortical strata. Moreover, UCP-5 was triggered by CSD, indicating that UCP-5 production can have a neuroprotective effect. Keywords: cortical spreading depression, neuroprotective effect, uncoupling protein-5

  20. Bazedoxifene for the prevention of postmenopausal osteoporosis

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    Luigi Gennari

    2008-09-01

    Full Text Available Luigi Gennari, Daniela Merlotti, Vincenzo De Paola, Giuseppe Martini, Ranuccio NutiDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scotte 53100-Siena, ItalyAbstract: Bazedoxifene acetate is a novel, chemically distinct selective estrogen receptor modulator (SERM that has been specifically developed after a stringent preclinical screening in order to obtain favorable effects on the skeleton and lipid metabolism with the additional improvement of a neutral effect on hot flushes and without stimulating the uterus or the breast. In both preclinical and clinical studies this SERM was shown to maintain BMD, prevent fractures, and reduce total cholesterol. Moreover, bazedoxifene also showed an improved uterine profile and demonstrated estrogen antagonistic activity on the endometrium. Importantly, this latter capacity has led to the development of a novel class of menopausal therapy called tissue selective estrogen complex (TSEC, in which bazedoxifene is combined with conjugated estrogen. The rationale for selecting bazedoxifene as the SERM in this TSEC combination is that it may offset estrogen stimulation of endometrial and breast tissue, without the necessity of using a progestin in women with an intact uterus, without aggravating menopausal vasomotor symptoms, but with an additive effect on bone. Preliminary data from phase 3 clinical trials appear to confirm this hypothesis, showing a greater effect of bazedoxifene on BMD with respect to raloxifene, coupled with efficacy on menopausal vasomotor symptoms not achieved by SERM alone. These properties and the safety profile of this combination, if confirmed long-term in ongoing phase 3 trials, might significantly affect the way women and physicians approach menopause and its related disorders.Keywords: bazedoxifene, SERM, estrogen, postmenopausal osteoporosis, treatment

  1. Rapid generation of value added products for seismic crisis management, using ground and satellite data

    Science.gov (United States)

    Salvi, Stefano; Atzori, Simone; Pezzo, Giuseppe; Merryman Boncori, John Peter; Tolomei, Cristiano; Antonioli, Andrea; Trasatti, Elisa; Zoffoli, Simona; Coletta, Alessandro

    2013-04-01

    Rapid generation of value added products for seismic crisis management, using ground and satellite data Stefano Salvi (1), Simone Atzori (1), Giuseppe Pezzo (1), John Peter Merryman Boncori (1), Cristiano Tolomei (1), Andrea Antonioli (1), Elisa Trasatti (1), Simona Zoffoli (2), Alessandro Coletta (2) (1): Istituto Nazionale di Geofisica e Vulcanologia, Centro Nazionale Terremoti, via di Vigna Murata 605, 00143 Roma, Italy (2): Agenzia Spaziale Italiana, Unità Osservazione della Terra, Viale Liegi 26, 00198, Roma, Italy The increased availability of Earth Observation optical and SAR data occurred in the last few years, has stimulated new applications in many different fields. The foreseen launch of new space platforms as the Sentinel satellites, providing good monitoring frequencies and free worldwide access to data is expected to increase the number of scientific and commercial activities exploiting EO data. In the sector of natural hazards the EO data have already demonstrated to be indispensable for the generation of information products for the prevention, and emergency management phases. In particular, the Italian Space Agency has promoted and funded, together with INGV, the development of dedicated infrastructures for the generation of advanced information products supporting different phases of the seismic and volcanic risk management cycles. These products were based mainly on SAR data from the COSMO-SkyMed 4-satellite constellation, and on optical data from commercial and scientific platforms, integrated with data from ground monitoring networks. During the last few years, such infrastructures have been tested under operational conditions and the products distributed to the Italian Civil Protection authority for validation and assessment. Here, with reference to the earthquake emergency management, we will present the infrastructure, the rapid mapping information products and some examples of activities during the latest seismic crises.

  2. Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill

    Directory of Open Access Journals (Sweden)

    Maurizio Guida

    2010-08-01

    Full Text Available Maurizio Guida, Giuseppe Bifulco, Attilio Di Spiezio Sardo, Mariamaddalena Scala, Loredana Maria Sosa Fernandez, Carmine NappiDipartimento di Scienze Ostetriche Ginecologiche Urologiche e Medicina della Riproduzione Umana, Università degli Studi “Federico II”, Napoli, Italia Abstract: The aim of this review is to define the role of the combined dienogest (DNG/­estradiol valerate (E2V contraceptive pill, in terms of biochemistry, metabolic and ­pharmacological effects and clinical application as well. E2V is the esterified form of 17β-estradiol (E2, while dienogest is a fourth-generation progestin with a partial antiandrogenic effect. The cycle stability is achieved with 2 to 3 mg DNG, supporting contraceptive efficacy. In this new oral contraceptive, E2V is combined with DNG in a four-phasic dose regimen (the first two tablets contain 3 mg E2V; the next five tablets include 2 mg E2V + 2 mg DNG, followed by 17 tablets with 2 mg E2V + 3 mg DNG; followed by two tablets with 1 mg E2V only, and finally two placebo tablets. Duration and intensity of scheduled withdrawal bleeding are lower with this ­contraceptive pill, whereas the incidence and the intensity of intra-cyclic bleeding are similar to the other oral contraceptive. With this new pill the levels of high density lipoprotein increased, while the levels of prothrombin fragment 1 + 2 and D-dimer remained relatively unchanged; the levels of sex hormone binding globulin, cortisol binding globulin, thyroxine binding globulin increased. The most frequently reported adverse events are: breast pain, headache, acne, alopecia, migraine, increase of ­bodyweight. The satisfaction rate is about 79.4%.Keywords: estradiol valerate, dienogest, combined oral contraceptive, four-phasic regimen, contraceptive safety

  3. Neuroprotection and acidosis induced by cortical spreading depression

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    Kwong KK

    2016-12-01

    Full Text Available Kenneth K Kwong, Suk-tak Chan Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA We read with interest the article “Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5” published in Neuropsychiatr Dis Treat by Viggiano et al.1 The authors showed that cerebral spreading depression (CSD triggered uncoupling protein-5 (UCP-5,1 which had been reported to exert a long-term effect upon neuron protection.2 The result is another piece in CSD literature on modifying gene expressions to provide neuroprotection to subsequent ischemic episodes.3,4 Authors' replyGiovanni Messina1,2Emanuela Viggiano1,3Vincenzo Monda1Antonietta Messina1Fiorenzo Moscatelli2Anna Valenzano2Domenico Tafuri4Vincenzo De Luca5Giuseppe Cibelli2Marcellino Monda1 1Section of Human Physiology and Unit of Dietetic and Sport Medicine, Department of Experimental Medicine, Second University of Naples, Caserta, 2Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 3Department of Medicine, University of Padua, Padua, 4Department of Motor Sciences and Wellness, University of Naples “Parthenope,” Napoli, Italy; 5Department of Psychiatry, University of Toronto, Toronto, ON, Canada Thank you for the attention paid to our article entitled: “Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5”.1 We do agree that cerebral spreading depression (CSD-induced acidosis is an intriguing aspect of the neuroprotection puzzle. It is well known that CSD is involved in the pathophysiology of migraine, cerebral ischemia, subarachnoid hemorrhage, and traumatic brain injury.2–7 View the original paper by Viggiano and colleagues. 

  4. Clinical features and imaging findings in a case of Capgras syndrome

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    Luca M

    2013-08-01

    Full Text Available Maria Luca,1 Andrea Bordone,1 Antonina Luca,2 Andrea Patti,1 Giuseppe Sortino,3 Carmela Calandra11Department of Medical and Surgery Specialties, Psychiatry Unit, 2Department GF Ingrassia, Section of Neuroscience, 3Department of Diagnostic Imaging, Radiology Unit, University Hospital Policlinico-Vittorio Emanuele, Catania, Sicily, ItalyAbstract: Capgras syndrome consists of the delusional belief that a person or persons have been replaced by doubles or impostors. It can occur in the context of both psychiatric and organic illness, and seems to be related to lesions of the bifrontal and right limbic and temporal regions. Indeed, magnetic resonance imaging has revealed brain lesions in patients suffering from Capgras syndrome. This case study reports the findings of a thorough diagnostic evaluation in a woman suffering from Capgras syndrome and presenting with the following clinical peculiarities: obsessive modality of presentation of the delusional ideation, intrusiveness of such ideation (that even disturbed her sleep, as well as a sense of alienation and utter disgust towards the double. These characteristics bring to mind the typical aspects of obsessive-compulsive disorder. Neuroanatomic investigation, through magnetic resonance imaging, performed on this patient showed alteration of the bilateral semioval centers, which are brain regions associated with the emotion of disgust and often show alterations in subjects suffering from obsessive-compulsive disorder. Hence, neuroimaging allows researchers to put forward the hypothesis of a common neuroanatomic basis for Capgras syndrome and obsessive-compulsive disorder, at least for cases in which the delusional ideation is associated with deep feelings of disgust and presents with a certain pervasiveness.Keywords: Capgras syndrome, magnetic resonance imaging, electroencephalography, obsessive-compulsive disorder, semioval centers

  5. Neoadjuvant therapy for locally advanced melanoma: new strategies with targeted therapies

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    La Greca M

    2014-06-01

    Full Text Available Michele La Greca,1 Giuseppe Grasso,2 Giovanna Antonelli,1 Alessia Erika Russo,1 Salvatore Bartolotta,3 Alessandro D’Angelo,1 Felice Vito Vitale,1 Francesco Ferraù1 1Medical Oncology Department, San Vincenzo Hospital, Taormina, Messina, Italy; 2Pathology Department, San Vincenzo Hospital, Taormina, Messina, Italy; 3Surgical Unit, Casa di Cura Gretter-Lucina, Catania, Catania, Italy Abstract: Neoadjuvant chemotherapy has been successfully tested in several bulky solid tumors, but it has not been utilized in advanced cutaneous melanoma, primarily because effective medical treatments for this disease have been lacking. However, with the development of new immunotherapies (monoclonal antibodies specific for cytotoxic T lymphocyte-associated antigen 4 [anti-CTLA-4] and programmed death protein-1 [anti-PD1] and small molecules interfering with intracellular pathways (anti-BRAF and mitogen-activated protein kinase kinase [anti- MEK] the use of this approach is becoming a viable treatment strategy for locally advanced melanoma. The neoadjuvant setting provides a double opportunity for a better knowledge of these drugs: a short-term evaluation of their intrinsic activity, and a deeper analysis of their action and resistance-induction mechanisms. BRAF inhibitors seem to be ideal candidates for the neoadjuvant setting, because of their prompt, repeatedly confirmed response in V600E BRAF-mutant metastatic melanoma. In this report we summarize studies focused on the neoadjuvant use of traditional medical treatments in advanced melanoma and anecdotal cases of this approach with the use of biologic therapies. Moreover, we discuss our experience with neoadjuvant targeted therapy as a priming for radical surgery in a patient with BRAF V600E mutation-positive advanced melanoma. Keywords: neoadjuvant setting, biologic, targeted therapy, vemurafenib, advanced melanoma

  6. New options in the management of tendinopathy

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    Nicola Maffulli

    2010-03-01

    Full Text Available Nicola Maffulli1, Umile Giuseppe Longo2, Mattia Loppini2, Filippo Spiezia2, Vincenzo Denaro21Centre for Sports and Exercise Medicine, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Mile End Hospital, London, England; 2Department of Orthopedic and Trauma Surgery, Campus Biomedico University, Rome, ItalyAbstract: Tendon injuries can be acute or chronic, and caused by intrinsic or extrinsic factors, either alone or in combination. Tendinopathies are a common cause of disability in occupational medicine and account for a substantial proportion of overuse injuries in sports. Tendinopathy is essentially a failed healing response, with haphazard proliferation of tenocytes, abnormalities in tenocytes, with disruption of collagen fibres and subsequent increase in noncollagenous matrix. The scientific evidence base for managing tendinopathies is limited. What may appear clinically as an “acute tendinopathy” is actually a well advanced failure of a chronic healing response in which there is neither histologic nor biochemical evidence of inflammation. In this review we report the new options for the management of tendinopathy, including eccentric exercises, extracorporeal shockwave therapy, injections (intratendinous injections of corticosteroids, aprotinin, polidocanol platelet-rich plasma, autologous blood injection, high-volume injections and surgery. Open surgery aims to excise fibrotic adhesions, remove areas of failed healing and make multiple longitudinal incisions in the tendon to detect intratendinous lesions, and to restore vascularity and possibly stimulate the remaining viable cells to initiate cell matrix response and healing. New surgical techniques aim to disrupt the abnormal neoinnervation to interfere with the pain sensation caused by tendinopathy. These procedures are intrinsically different from the classical ones in present use, because they do not attempt to address directly the pathologic

  7. An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia

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    Bove M

    2017-02-01

    Full Text Available Marilisa Bove, Arrigo Francesco Giuseppe Cicero, Maddalena Veronesi, Claudio Borghi Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy Abstract: Several studies suggest that chronic hyperuricemia, the main precursor of gout, is involved in the pathogenesis of different systemic disorders that affect cardiovascular and renal systems, such as hypertension, obesity, hypercholesterolemia, atherosclerosis, metabolic syndrome, chronic heart failure, and chronic kidney disease. Recent epidemiological evidence has shown an increasing trend in the prevalence of hyperuricemia and gout in the Western world: a number of population-based studies estimate a prevalence of up to 21% for hyperuricemia and 1%–4% for gout. As such, early detection and careful management of this pathological condition is required, starting from lifestyle changes (mainly based on a diet low in red meat, sugars, and alcoholic beverages, with increased intake of vegetables, water, and vitamin C sources, adding specific drugs to lead serum uric acid (SUA levels under the target value of 7 mg/dL. In particular, nonselective and selective XO inhibitors (allopurinol, oxypurinol, febuxostat reduce SUA levels and the overproduction of reactive oxygen species, mainly related to XO overactivity that often causes inflammatory damage to the vascular endothelium. The effect of lowering SUA levels via XO inhibition includes an attenuation of oxidative stress and related endothelial dysfunction that largely contribute to the pathophysiology of metabolic syndrome and cardiovascular diseases. Therefore, the inhibition of XO overactivation seems to be an excellent therapeutic option to limit the harmful effects of excess UA and reactive oxygen species. In conclusion, rapid diagnosis and correct therapy for hyperuricemia may also improve the prevention and/or treatment of serious and multifactorial diseases. The available evidence supports the importance of

  8. A comparison of wood density between classical Cremonese and modern violins.

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    Berend C Stoel

    Full Text Available Classical violins created by Cremonese masters, such as Antonio Stradivari and Giuseppe Guarneri Del Gesu, have become the benchmark to which the sound of all violins are compared in terms of their abilities of expressiveness and projection. By general consensus, no luthier since that time has been able to replicate the sound quality of these classical instruments. The vibration and sound radiation characteristics of a violin are determined by an instrument's geometry and the material properties of the wood. New test methods allow the non-destructive examination of one of the key material properties, the wood density, at the growth ring level of detail. The densities of five classical and eight modern violins were compared, using computed tomography and specially developed image-processing software. No significant differences were found between the median densities of the modern and the antique violins, however the density difference between wood grains of early and late growth was significantly smaller in the classical Cremonese violins compared with modern violins, in both the top (Spruce and back (Maple plates (p = 0.028 and 0.008, respectively. The mean density differential (SE of the top plates of the modern and classical violins was 274 (26.6 and 183 (11.7 gram/liter. For the back plates, the values were 128 (2.6 and 115 (2.0 gram/liter. These differences in density differentials may reflect similar changes in stiffness distributions, which could directly impact vibrational efficacy or indirectly modify sound radiation via altered damping characteristics. Either of these mechanisms may help explain the acoustical differences between the classical and modern violins.

  9. From the history of the recognitions of the remains to the reconstruction of the face of Dante Alighieri by means of techniques of virtual reality and forensic anthropology

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    Stefano Benazzi

    2007-07-01

    Full Text Available The work consists of the reconstruction of the face of the great poet called Dante Alighieri through a multidisciplinary approach that matches traditional techniques (manual ones, usually used in forensic anthropology, with digital methodologies that take advantage of technologies born in manufacturer-military fields but that are more and more often applied to the field of the cultural heritage. Unable to get the original skull of Dante, the work started from the data and the elements collected by Fabio Frassetto and Giuseppe Sergi, two important anthropologists, respectively at the University of Bologna and Rome, in an investigation carried out in 1921, sixth century anniversary of his death, on the remains of the poet collected in Ravenna. Thanks to this, we have a very accurate description of Dante’s bones, including 297 metric data inherent to the whole skeleton, some photographs in the scale of the skull, the various norms and many other bones, as well as a model of the skull subsequently realized by Frassetto. According to these information, a geometric reconstruction of Dante Alighieri skull including the jaw was carried out through the employment and integration of the instruments and technologies of the virtual reality, and from this the relative physical model through fast prototype was realized. An important aspect of the work regards in a particular manner the methodology of 3D modelling proposed for the new reconstruction of the jaw (not found in the course of the 1921 recognition, starting from a reference model. The model of the skull prototype is then useful as the basis for the successive stage of facial reconstruction through the traditional techniques of forensic art.

  10. Long-term adherence to CPAP treatment in patients with obstructive sleep apnea: importance of educational program

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    La Piana GE

    2011-11-01

    Full Text Available Giuseppe Emanuele La Piana1, Alessandro Scartabellati1, Lodovico Chiesa1, Luca Ronchi1, Paola Raimondi1, Miriam A Carro1, Silvia Zibetti1, Stefano Aiolfi2 1Pulmonary Rehabilitation Unit, S. Marta Hospital, Rivolta D'Adda; 2Unit of Pneumology, AO Ospedale Maggiore di Crema, Crema, Italy Background: Lack of adherence with continuous positive airway pressure (CPAP therapy is the major cause of treatment failure in patients with obstructive sleep apnea syndrome. We evaluated the effectiveness of our intensive educational program on adherence in the short term and the long term. Methods: The educational program consisted of: intensive training, whereby each patient performed individual and collective sessions of three hours receiving information about obstructive sleep apnea syndrome, familiarizing themselves with CPAP tools, on six consecutive days; long-term training; and support meetings, with reassessment at three months and one year. Results: In 202 patients with obstructive sleep apnea syndrome, the mean (standard deviation apnea/hypopnea index was 45 ± 22, the Epworth Sleepiness Scale score was 14 ± 5, and the average titration pressure was 10 ± 2 cm H2O. At three months, 166 patients (82% used CPAP for an average of 7.3 hours per night. At one year, 162 (80% used CPAP for about seven hours per night. At two years, 92 patients (43% used CPAP for about five hours per night. The level of satisfaction remained higher in patients in ventilation. Conclusion: Our data show strong adherence to CPAP at three months and one year, with a decrease at two years. The initial educational program seems to play an important role in adherence. This effect is lost in the long term, suggesting that periodic reinforcement of educational support would be helpful. Keywords: adherence, continuous positive airway pressure, obstructive sleep apnea syndrome, educational program

  11. 科尔诺的图书馆

    Institute of Scientific and Technical Information of China (English)

    张硕松(译); 周荃(审)

    2013-01-01

    建筑师:Archea Associati, Florence项目建筑师:Marco Casamonti ( 项目建筑师) Laura Andreini, Silvia Fabi, Giovanni Polazz 设计团队: Ezio Birondi, Giuseppe Pezzano 结构工程师: Studio Myallonnier, Bergamo科尔诺是贝加莫省传统的几个繁荣社区之一。在现有的市政设施里再添加一座图书馆和剧院的想法最早出现在1997年,但十年后才开始动工。对于古罗马剧场座位形式——梯形坐席的当代诠释是设计的出发点:建筑屋顶也是室外坐席台阶。台阶是建筑的特色,和广场一起为室外活动提供了框架支持。长走廊丰富了空间概念。走道两侧的钢筋混凝土墙超过9m高、40cm厚。除了作为建筑支撑体,它还分割了防火分区,而且在两个区域之间起到缓冲区的作用:一边是活动区,

  12. Results of case-control studies support the association between contact lens use and Acanthamoeba keratitis

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    Pacella E

    2013-05-01

    Full Text Available Elena Pacella,1 Giuseppe La Torre,2 Maria De Giusti,2 Chiara Brillante,1 Anna Maria Lombardi,2 Gianpaolo Smaldone,1 Tommaso Lenzi,1 Fernanda Pacella11Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Italy; 2Department of Public Health and Infectious Diseases, Faculty of Pharmacy and Medicine, Sapienza University of Rome, ItalyBackground: Acanthamoeba keratitis (AK is ever more frequently reported in industrialized countries. The loss of the corneal surface integrity consequent to secondary microtrauma produced by the use of contact lens (CL favors the penetration of the parasite into the corneal tissue.Objectives: A scientific review was performed to investigate the association of CL wear as an Acanthamoeba keratitis (AK risk factor.Methods: A computerized screening of 7834 Medline articles (4623 from PubMed; 3211 from Scopus used a strict selection criteria of case-control studies involving CL wear and/or trauma.Results: The search yielded five case-control studies published from 1995 to 2012. All studies included showed a statistically significant positive association between AK and CL use, with a combined odds ratio (OR of 10.21 (95%, confidence intervals [CI]; 3.57–27.64.Statistical analysis: All studies included showed a statistically significant positive association between AK and CL use, though with differing OR values.Conclusion: Though rare, AK should be held in higher consideration when ophthalmologists are faced with CL users exhibiting simplex-like lesions associated with circular stromal infiltrates and disproportionate ocular pain in respect to the objective clinical picture.Keywords: keratitis, contact lens, Acanthamoeba

  13. Editorial

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    Salomón Kalmanovitz

    2015-06-01

    Full Text Available En este segundo número de tiempo&economía presentamos dos ensayos sobre temas fiscales en diferentes períodos y regiones. Salomón Kalmanovitz alarga su análisis sobre las cuentas fiscales del Estado Soberano de Panamá (Revista de Economía Institucional, No 27, 2012 a la nueva nación que surge de su separación de Colombia, auspiciada no sólo por el imperio norteamericano sino resentida por el maltrato que recibió del centro político colombiano. Su aporte es mirar con detenimiento las cuentas fiscales de Panamá en medio de un difícil proceso de construcción de Estado sin contar con el monopolio de los medios de violencia y sin disponer de su territorio más valioso. Junto con Giuseppe De Corso se estima el PIB de Panamá entre 1906 y 1945, que es el primer intento que se hace en este sentido y permite completar la serie que la Cepal hizo desde 1945 para todo el siglo XX. Claudia Chaves, por su parte, examina los conflictos fronterizos entre las provincias de Minas Gerais y Sao Paolo entre 1780 y 1815 en torno a la jurisdicción y administración financiera con el cambio que significó pasar de las juntas de hacienda real del Brasil colonial, a la creación del Erario Real del Imperio Portugués que se trasladó al Brasil tras la invasión de Napoleón a la península ibérica.

  14. The relationship between alexithymia, shame, trauma, and body image disorders: investigation over a large clinical sample

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    Franzoni E

    2013-02-01

    Full Text Available Emilio Franzoni,1 Stefano Gualandi,1 Vincenzo Caretti,2 Adriano Schimmenti,3 Elena Di Pietro,1 Gaetano Pellegrini,1 Giuseppe Craparo,3 Arianna Franchi,1 Alberto Verrotti,4 Alessandro Pellicciari11Child Neuropsychiatry Unit, University of Bologna, Italy; 2Department of Psychology, University of Palermo, Italy; 3Faculty of Human and Social Sciences, Kore University of Enna, Enna, Italy; 4Department of Pediatrics, University of Chieti, ItalyBackground: The connections between eating disorders (EDs and alexithymia have not been fully clarified. This study aims to define alexithymia's connections with shame, trauma, dissociation, and body image disorders.Methods: We administered the Dissociative Experience Scale-II, Trauma Symptom Inventory, Experience of Shame Scale, Toronto Alexithymia Scale-20, and Body Uneasiness Test questionnaires to 143 ED subjects. Extensive statistical analyses were performed.Results: The subjects showed higher scores on alexithymia, shame, dissociation, and traumatic feelings scales than the nonclinical population. These aspects are linked with each other in a statistically significant way. Partial correlations highlighted that feelings of shame are correlated to body dissatisfaction, irrespective of trauma or depressed mood. Multiple regression analysis demonstrates that shame (anorexic patients and perceived traumatic conditions (bulimic and ED not otherwise specified are associated with adverse image disorders.Conclusion: Shame seems to hold a central role in the perception of an adverse self-image. Alexithymia may be interpreted as being a consequence of previous unelaborated traumatic experiences and feelings of shame, and it could therefore be conceptualized as a maladaptive–reactive construct.Keywords: eating disorders, trauma, alexithymia, shame, body image

  15. Fully Human and Fully Divine: The Birth of Christ and the Role of Mary

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    Ann Milliken Pederson

    2015-03-01

    Full Text Available The task given to us for this article was to offer theological responses to, “Can modern biology interpret the mystery of the birth of Christ?” by Giuseppe Benagiano and Bruno Dallapiccola. We are female Protestant theologians and respond to the issues from this perspective. The Christian confession of the virgin birth of Jesus (stated within the Apostles and Nicene creeds is a statement of faith that God became incarnate through the power of the Holy Spirit in the flesh of the human Jesus and, likewise, that God continues to become incarnate in our flesh and in the messy details of our lives. The mystery and miracle of the birth of Jesus has much more to do with the incarnation of God in human flesh and in God’s spirit at work in and with Mary, than to do with Mary’s gynecological or parthenogenical mechanisms. The language of mechanism and miracle, in the ways used by the authors, can reduce the mystery and power of the incarnation. Consequently, we would like to offer a theological interpretation of the birth of Jesus and the role of Mary that expresses the mystery and grace of God’s incarnation not only in human nature, but also in all of nature. Our world is God’s home. We cannot comprehend all the ramifications of what is happening in the sciences and technologies of reproduction and development. However, what we do know is that we cannot stop asking questions, seeking answers, and remaining open to being both critical of, and appreciative of, what the sciences are teaching us about being human and creatures of God.

  16. Comparative pharmacokinetic and pharmacodynamic evaluation of branded and generic formulations of meloxicam in healthy male volunteers

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    Del Tacca M

    2013-07-01

    Full Text Available Mario Del Tacca,1,2 Giuseppe Pasqualetti,3 Giovanni Gori,1 Pasquale Pepe,1 Antonello Di Paolo,2 Marianna Lastella,2 Ferdinando De Negri,1 Corrado Blandizzi2 1Clinical Pharmacology Centre for Drug Experimentation, Pisa University Hospital, 2Department of Clinical and Experimental Medicine, 3Geriatrics Unit, University of Pisa, Pisa, Italy Purpose: The primary aim of the present study was to assess the pharmacokinetic bioequivalence between a generic formulation of meloxicam 15 mg tablets (Meloxicam Hexal and its respective brand product (Mobic, in order to verify whether the generic product conforms to the regulatory standards of bioequivalence in the postmarketing setting. As a secondary exploratory aim, the pharmacodynamic effects of the two formulations were also evaluated by means of rating scales following hyperalgesia induced by cutaneous freeze injury. Subjects and methods: A single 15 mg dose of generic or branded meloxicam tablets was administered to 24 healthy male volunteers in a crossover fashion. Plasma samples, collected for 24 hours after dosing, were assayed for meloxicam concentration by a validated high-performance liquid chromatography method. Results: The analysis of pharmacokinetic parameters did not show any significant difference between the two meloxicam formulations: the 90% confidence intervals fell within the acceptance range of 80%–125% (0.84–1.16 for area under the curve [0–24], and 0.89–1.23 for peak concentration. No difference in the pharmacodynamic end point was observed between the two groups. Conclusion: The pharmacokinetic profiles of the two meloxicam formulations confirm the regulatory criteria for bioequivalence; pharmacodynamic data indicate a similar antihyperalgesic effect. The two formulations can be used interchangeably in the clinical setting. Keywords: meloxicam, pharmacokinetics, healthy volunteers, generic drug, bioequivalence, postmarketing

  17. Performance of PLS regression coefficients in selecting variables for each response of a multivariate PLS for omics-type data

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    Giuseppe Palermo

    2009-05-01

    Full Text Available Giuseppe Palermo1, Paolo Piraino2, Hans-Dieter Zucht31Digilab BioVision GmbH, Hannover, Germany; 2Dr Paolo Piraino Statistical Consulting, Rende (CS, Italy; 3Proteome Sciences R&D GmbH and C. KG, Frankfurt am Main, GermanyAbstract: Multivariate partial least square (PLS regression allows the modeling of complex biological events, by considering different factors at the same time. It is unaffected by data collinearity, representing a valuable method for modeling high-dimensional biological data (as derived from genomics, proteomics and peptidomics. In presence of multiple responses, it is of particular interest how to appropriately “dissect” the model, to reveal the importance of single attributes with regard to individual responses (for example, variable selection. In this paper, performances of multivariate PLS regression coefficients, in selecting relevant predictors for different responses in omics-type of data, were investigated by means of a receiver operating characteristic (ROC analysis. For this purpose, simulated data, mimicking the covariance structures of microarray and liquid chromatography mass spectrometric data, were used to generate matrices of predictors and responses. The relevant predictors were set a priori. The influences of noise, the source of data with different covariance structure and the size of relevant predictors were investigated. Results demonstrate the applicability of PLS regression coeffi cients in selecting variables for each response of a multivariate PLS, in omics-type of data. Comparisons with other feature selection methods, such as variable importance in the projection scores, principal component regression, and least absolute shrinkage and selection operator regression were also provided.Keywords: partial least square regression, regression coefficients, variable selection, biomarker discovery, omics-data

  18. Modeling the structure of the attitudes and belief scale 2 using CFA and bifactor approaches: Toward the development of an abbreviated version.

    Science.gov (United States)

    Hyland, Philip; Shevlin, Mark; Adamson, Gary; Boduszek, Daniel

    2014-01-01

    The Attitudes and Belief Scale-2 (ABS-2: DiGiuseppe, Leaf, Exner, & Robin, 1988. The development of a measure of rational/irrational thinking. Paper presented at the World Congress of Behavior Therapy, Edinburg, Scotland.) is a 72-item self-report measure of evaluative rational and irrational beliefs widely used in Rational Emotive Behavior Therapy research contexts. However, little psychometric evidence exists regarding the measure's underlying factor structure. Furthermore, given the length of the ABS-2 there is a need for an abbreviated version that can be administered when there are time demands on the researcher, such as in clinical settings. This study sought to examine a series of theoretical models hypothesized to represent the latent structure of the ABS-2 within an alternative models framework using traditional confirmatory factor analysis as well as utilizing a bifactor modeling approach. Furthermore, this study also sought to develop a psychometrically sound abbreviated version of the ABS-2. Three hundred and thirteen (N = 313) active emergency service personnel completed the ABS-2. Results indicated that for each model, the application of bifactor modeling procedures improved model fit statistics, and a novel eight-factor intercorrelated solution was identified as the best fitting model of the ABS-2. However, the observed fit indices failed to satisfy commonly accepted standards. A 24-item abbreviated version was thus constructed and an intercorrelated eight-factor solution yielded satisfactory model fit statistics. Current results support the use of a bifactor modeling approach to determining the factor structure of the ABS-2. Furthermore, results provide empirical support for the psychometric properties of the newly developed abbreviated version.

  19. Managing hypertension in diabetic patients – focus on trandolapril/verapamil combination

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    Sanjib Kumar Sharma

    2007-09-01

    Full Text Available Sanjib Kumar Sharma1,3, Piero Ruggenenti1,2, Giuseppe Remuzzi1,2, 1Clinical Research Centre for Rare Diseases “Aldo e Cele Daccò”, Mario Negri Institute for Pharmacological Research, Villa Camozzi, Ranica, Italy; 2Unit of Nephrology, Azienda Ospedaliera, Ospedali Riuniti, Bergamo, Italy; 3Department of Medicine, BP Koirala Institute of Health Sciences, Dharan, NepalAbstract: Hypertensive diabetes individuals are at higher risk for cardiovascular events and progression to end stage renal disease. Several well conducted clinical trials indicate that aggressive treatment of hypertension in individual with diabetes reduces these complications. Combinations of two or more antihypertensive drugs are frequently required to reach the target blood pressure and to improve the cardiovascular and renal outcomes in these patients. There are physiological and clinical rationales for renin-angiotensin system blockade in hypertensive diabetics. Trandolapril/verapamil sustained released (SR is a fixed-dose combination of trandolapril and a sustained release formulation of verapamil and indicated in treatment of hypertension in patients who require more than one drug to reach target blood pressure. The antihypertensive efficacy of trandolapril/verapamil SR has been evaluated extensively in large trials. In the INVEST trial, a verapamil SR-based treatment strategy that included trandolapril in most patients was effective in reducing the primary outcome in hypertensive patients with coronary artery disease. The new onset of diabetes was also significantly lower in the verapamil SR/trandolapril treatment group in comparison with those on the atenolol/hydroclorothiazide treatment group. The BErgamo NEphrologic DIabetes Complications Trial (BENEDICT documented that in hypertensive diabetes and normoalbuminuria, trandolapril plus verapamil or trandolapril alone delayed the onset of microalbuminuria independent of their blood pressurereducing effect. Thus

  20. [Italy of miracles. Does the renaissaince of Italian science pass by the Vatican?].

    Science.gov (United States)

    Naldi, Luigi

    2016-03-01

    In a commentary published in The Lancet on January 2016, Giuseppe Remuzzi and Richard Horton, analyse the origin of the decline of the Italian primacy in biomedical science. Among the others, the existence of Italian political groups «which oppose science simply to please the Church and to achieve political gain» was considered as detrimental for advancing research in such areas as assisted reproduction or embryonic stem cell research. Some hope for a change is raised, in the opinion of Remuzzi and Horton, by the more open attitude toward science of pope Francis. Hence, the two authors conclude that the time has come to promote a dialogue between Italian scientists and the Vatican and, by that, to see «if conditions are ripe to create a renaissance in Italian intellectual life». I humbly challange the analyses and conclusions of Remuzzi and Horton on the Italian scientific decline and the possible way forward. The rooth of the Italian decline in science are deep-seated into the chronic lack of resources, into the under-development of academic institutions, and into the lack of motivations for young researchers. As for bioethical paradigms, they are the end result of a co-production between social norms and scientific development, and their definition would ideally involve the participation of large sectors of the society. One example of such a process is offered by the "Les Etats généraux de la bioéthique" in France in 2009. The ethical discussion concerning biotech innovations is not limited to theological issues, but involves social aspects such as public health priorities, equity, and information strategies to avoid creating unrealistic expectations.

  1. Italian contributions to Turkish paediatrics during the Ottoman Empire.

    Science.gov (United States)

    Yurdakok, Murat; Cataldi, Luigi

    2013-01-01

    The Ottoman Empire maintained close relations with the neighbouring Italian city states in the 16th and 17th century. Yacub Pasha (1425-1481), personal physician of Mehmed II the Conqueror, was an Italian Jew who advanced to the title of pasha and vizier. Domenico Hierosolimitano (ca. 1552-1622), the third physician to Sultan Murad III, was a Jerusalemite rabbi. His book is an important source about everyday life and medical practice in Istanbul at the time. Nuh bin Abd al-Mennab (1627-1707), also of Italian stock, was the Chief Physician of the Ottoman Empire, who translated a pharmacopoeia into Turkish. In the same century, two Italians, Israel Conegliano (Conian) and Tobia Cohen became private physicians to leading Ottoman pashas and the Grand Vizier. A. Vuccino (1829-1893) and Antoine Calleja Pasha (1806-1893) taught at the Istanbul Medical School. Italy was a favoured country for medical education during the early period of Ottoman westernisation. Sanizade Mehmet Ataullah Efendi (1771-1826) translated the first medical book printed in the Ottoman Empire from Italian into Turkish. Mustafa Behcet Efendi (1774-1833), chief physician to the Sultan and the founder of the first western medical school in Turkey, translated several medical books from Italian into Turkish. The first printed pharmacopeia in the Ottoman Empire was also originally Italian In the 19th century, Edouard Ottoni and his son Giuseppe Ottoni were well-known military pharmacists, both under the name of Faik Pasha. Probably the most influential physician of Italian origin was Giovanni Battista Violi (1849-1928), who had practiced paediatrics in Turkey for more than fifty years. Violi was the founder of the first children's hospital, the first vaccine institute, and the first paediatric journal in the Ottoman Empire.

  2. BeppoSAX equatorial uncontrolled re-entry

    Science.gov (United States)

    Portelli, C.

    The X-ray astronomy satellite BeppoSAX (Satellite per Astronomia X, "Beppo" in honor of Giuseppe Occhialini), is a project of the Italian Space Agency (ASI) with participation of the Netherlands Agency for Aerospace Programs (NIVR). BeppoSAX was launched by an Atlas G Centaur directly into a circular 600 km- orbit at 3.9 degrees inclination on April 30th, 1996. The satellite is a three axis stabilized spacecraft with a total mass of about 1400 kg. The current (May 1, 2002) flight altitude is about 470 km and its uncontrolled re-entry is predicted late in 2002, or in 2003, with a 26 kg of hydrazine on board that could not be vented or used for controlled re-entry due to gyro's package total failure. Due to the relatively high mass of BeppoSAX, it has to be expected that parts of the satellite will survive the re-entry into the earth atmosphere. The Italian Space Agency has committed a study to HTG for the analysis of the destructive phase of the uncontrolled atmospheric re-entry by means of a dedicated European software tool (SCARAB). The expected outputs will be used in order to determine how much of the spacecraft and how many fragments parts of it will reach the ground on the equatorial earth zone. This paper will address the peculiarities of the spacecraft initial status, its risks at end of life and the SCARAB modelling as well as its 6D flight dynamics re-entry analysis results also in terms of the destruction history tree. Consideration will be made on the ground dispersion and casualt y area due to the very restricted equatorial zone impacted. References B. Fritsche, H. Klinkrad, A. Kashkovsky, E.Grinberg; Spacecraft Disintegration during uncontrolled atmospheric entry ; IAA-99-IAA.6.7.02; 50t h IAC 4-8 Oct. 1999

  3. The legacy of Pompeii and its volcano.

    Science.gov (United States)

    de Divitiis, Enrico; Cappabianca, Paolo; Esposito, Felice; Cavallo, Luigi M

    2004-10-01

    On August 24, AD 79, a terrible eruption of Mount Vesuvius deranged life in beautiful Pompeii and killed thousands of men, women, and children. They were restored to us by the fact that Mount Vesuvius, with its rain of ashes, proved to be a skilled sculptor, preserving the shape and even the wrinkles in the clothes the Pompeians wore while trying to escape during the day of the tragedy. The detailed description of Plinius the Younger and modern static studies of the eruptive residues have made it possible to reconstruct with great accuracy the various phases of the eruption that took place 2000 years ago, including the hours and days during which the phenomena first became obvious. Today, almost 2000 years later, Pompeii has reawakened and risen from its sepulcher of ashes thanks to the excavations initiated under King Charles III of Bourbon in 1748. Excavations proceeded slowly under the Bourbons, with the aim of enriching the Bourbon Museum of Naples rather than of classifying the ruins and placing them into a historical context. Under Joachim Murat, interest in the town planning and architecture of the uncovered cities reemerged, especially with respect to Pompeii. In 1860, however, with the establishment of the Kingdom of Italy, the excavations, now under the direction of archaeologist Giuseppe Fiorelli, were provided new impetus and, finally, a scientific basis. Today, the excavations are giving us back extraordinary evidence concerning the culture, the everyday life, the habits, the architecture, and the wonderful frescoes of the Roman cities of southern Italy, making possible the statement that Pompeii is "the most alive of the dead cities."

  4. SoCIAL – training cognition in schizophrenia: a pilot study

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    Palumbo D

    2017-07-01

    Full Text Available Davide Palumbo,* Armida Mucci,* Giuseppe Piegari, Valentina D’Alise, Annapaola Mazza, Silvana Galderisi Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy *These authors contributed equally to this work Abstract: The purpose of this pilot study was to assess the efficacy of a new social cognition (SC remediation intervention, the Social Cognition Individualized Activities Lab (SoCIAL, for subjects with schizophrenia. The training includes a module for emotion recognition and one for theory of mind. A comparison with a validated cognitive remediation intervention, the Social Skills And Neurocognitive Individualized Training (SSANIT, was conducted to verify the efficacy of the SoCIAL in improving SC. Ten stabilized patients with schizophrenia accepted to participate. Five patients were randomized to SoCIAL and five to SSANIT. The SoCIAL intervention includes individual sessions of neurocognitive individualized training (NIT and group sessions of SC training. SSANIT includes individual sessions of NIT and group sessions of social skills individualized training. The interventions were matched for the overall treatment duration (20 weeks and for the frequency of the sessions (two times a week, one for SoCIAL or social skills individualized training and one for NIT, with a duration of 80 minutes for each session. Results showed a significant treatment effect (effect size: Cohen’s d 0.32 on the primary outcome; in fact, only the SoCIAL intervention improved theory of mind. Patients receiving the SoCIAL intervention also showed an improvement of avolition. These preliminary findings support further development of the SoCIAL and suggest that cognitive remediation should include an SC module. Keywords: cognitive remediation, psychiatric rehabilitation, negative symptoms, avolition, MATRICS consensus cognitive battery, MCCB

  5. Use of cluster analysis to describe desaturator phenotypes in COPD: correlations between pulmonary function tests and nocturnal oxygen desaturation

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    Toraldo DM

    2011-11-01

    Full Text Available Domenico Maurizio Toraldo1, Francesco De Nuccio2, Annarita Gaballo1, Giuseppe Nicolardi21A Galateo Lung Disease Hospital, Regional Service Puglia, San Cesario di Lecce, 2Laboratory of Human Anatomy, Department of Biological and Environmental Sciences and Technologies, University of Lecce, Lecce, ItalyBackground: Significant heterogeneity of clinical presentation and disease progression exists within chronic obstructive pulmonary disease (COPD. Although forced expiratory volume in 1 second (FEV1 inadequately describes this heterogeneity, a clear alternative has not emerged. This article discusses and refines the concept of phenotyping desaturators in COPD and shows a possible pattern which could be used as a framework for future research.Recent findings: COPD is a complex condition with pulmonary and extrapulmonary manifestations. We suggest that COPD phenotypes should be associated with clinically meaningful outcomes. The innovation of COPD phenotyping is defined as COPD desaturators. Sleep-related hypoxemia and hypercapnia are well recognized in COPD and the development of systemic inflammation during sleep. These sleep-related changes predispose to nocturnal cardiac arrhythmias, pulmonary hypertension, and possibly death, particularly during acute exacerbations.Conclusion: A more focused definition makes possible a classification of patients into two distinct subgroups for both clinical and research purposes. Establishing a common language for future research will facilitate our understanding and management of such diseases. Even if different treatment strategies have different outcomes for these groups, we will have confirmation, or otherwise, of the clinical value of cluster analysis. This knowledge could lead to pharmacological treatment and other interventions directed to specific phenotypic groups.Keywords: phenotypes, chronic obstructive pulmonary disease, desaturator, nocturnal hypoxemia, systemic inflammation, intermittent hypoxia

  6. Effects of maintenance lithium treatment on serum parathyroid hormone and calcium levels: a retrospective longitudinal naturalistic study

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    Albert U

    2015-07-01

    Full Text Available Umberto Albert,1 David De Cori,1 Andrea Aguglia,1 Francesca Barbaro,1 Fabio Lanfranco,2 Filippo Bogetto,1 Giuseppe Maina3 1Anxiety and Mood Disorders Unit, Rita Levi Montalcini Department of Neuroscience, University of Turin, Torino, Italy; 2Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Torino, Italy; 3Department of Mental Health, San Luigi-Gonzaga Hospital, University of Turin, Orbassano, Italy Objective: The aim of this retrospective longitudinal naturalistic study was to evaluate the effects of maintenance lithium treatment on parathyroid hormone (PTH and calcium levels. Methods: A retrospective longitudinal naturalistic study design was used. Data were collected from the database of a tertiary psychiatric center covering the years 2010–2014. Included were bipolar patients who had never been exposed to lithium and had lithium started, and who had PTH, and total and ionized calcium levels available before and during lithium treatment. Paired t-tests were used to analyze changes in PTH and calcium levels. Linear regressions were performed, with mean lithium level and duration of lithium exposure as independent variables and change in PTH levels as dependent variable. Results: A total 31 patients were included. The mean duration of lithium treatment was 18.6±11.4 months. PTH levels significantly increased during lithium treatment (+13.55±14.20 pg/mL; the rate of hyperparathyroidism was 12.9%. Neither total nor ionized calcium increased from baseline to follow-up; none of our patients developed hypercalcemia. Linear regressions analyses did not show an effect of duration of lithium exposure or mean lithium level on PTH levels. Conclusion: Lithium-associated stimulation of parathyroid function is more common than assumed to date. Among parameters to be evaluated prior to lithium implementation, calcium and PTH should be added. Keywords: bipolar disorder, follow-up study, lithium

  7. Integrated Geophysical and Archaeological investigations to study the site of Aquinum (Frosinone, Italy)

    Science.gov (United States)

    Piro, Salvatore; Ceraudo, Giuseppe; Zamuner, Daniela

    2010-05-01

    To enhance the knowledge finalised to the location and conservation of the unknown buried structures below the actual studied levels, in the territory of the Ancient Aquinum (Frosinone, Italy) a scientific collaboration, inside the "Ager Aquinas Project" between the University of Salento (Department of Cultural Heritage - Laboratory of Ancient Topography and Photogrammetry) and the Institute of Technologies Applied to Cultural Heritage (ITABC-C.N.R.) has been developed, during 2008-2009 and it is still in progress. The site which is the subject of this paper had been identified in the past through air photo interpretation of vertical historical coverage and field - walking surveys. Ancient Aquinum is characterised by two main aspects: the first depends by the presence of a very big defence-system with mighty walls and large ditch; the second characteristic is the presence or regular but not orthogonal road - system of the town, bordered by an unusual parallelogram shape of the blocks. With the results obtained after the elaborations of the first aerial data sets and field surveys, has been possible to map the main town - planning, drawing the main road system inside and outside the town. Although the analysis of the air photo evidence allowed the global interpretation of the site, it was not possible to reconstruct the archaeological evidences in the central portion of the town. Therefore the Project, during 2008, started with new acquisition and elaboration of aerial photos, field-walking surveys and GPR surveys with the aim to better define the urban plan of the central portion of the ancient town. The location, depth, and size of the buried buildings were effectively estimated from non-destructive remote sensing with a gradiometric and ground-penetrating radar systems. Recent archaeological excavations made (by Prof. Giuseppe Ceraudo - University of Salento, Lecce) during the summer 2009, have confirmed the structures individuated with the geophysical methods

  8. PhD Dissertations

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    Redazione Reti Medievali (a cura di

    2002-06-01

    Full Text Available Report of PhD dissertation. Laura Baietto Una politica per le città. Rapporti fra papato, vescovi e comuni nell'Italia centro-settentrionale da Innocenzo III a Gregorio IX, Tesi di dottorato di ricerca in Storia Medievale, Università degli Studi di Torino, 2002   Giuseppe Banfo Compresenze e sovrapposizioni di poteri territoriali di qualità diversa tra X e XIII: il caso del basso Monferrato, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Torino, 2002   Francesca Dell'Acqua La vetrata tra l'età tardo imperiale e l'altomedioevo: le fonti, l'archeologia, Tesi di Perfezionamento in Storia dell'Arte Medievale, Scuola Normale Superiore di Pisa, 2001   Primo Giovanni Embriaco I vescovi di Albenga e gli sviluppi signorili nella Liguria occidentale (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Torino, 2001   Antonella Ghignoli Documenti e proprietà altomedievali. Fondamenti e problemi dell'esegesi storica delle fonti documentarie nello specchio della tradizione delle carte pisane dei secoli VIII-XI, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Firenze, 2002   Vito Loré Espansione monastica e mutamenti politici. La Trinità di Cava nei suoi rapporti con i sovrani longobardi e normanni e con l'aristocrazia territoriale. Secoli XI-XII, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Firenze, 2002   Rosaria Stracuzzi Messina nel '400, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Palermo, 2001   Stefania Tamburini Le "portate" ecclesiastiche nel piviere di San Giovanni in Firenze nel 1427. Spunti per una riflessione sul patrimonio ecclesiastico della diocesi fiorentina,Tesi di dottorato di ricerca in Storia e informatica, Università degli Studi di Bologna, 2001

  9. Ulipristal acetate: a novel pharmacological approach for the treatment of uterine fibroids

    Directory of Open Access Journals (Sweden)

    Biglia N

    2014-02-01

    Full Text Available Nicoletta Biglia,1 Silvestro Carinelli,2 Antonio Maiorana,3 Marta D'Alonzo,1 Giuseppe Lo Monte,4 Roberto Marci4 1Department of Obstetrics and Gynaecology, Mauriziano "Umberto I" Hospital, University of Turin, Turin, 2Department of Pathology, European Institute of Oncology, Milan, 3Department of Obstetrics and Gynecology, ARNAS Civico Hospital, Palermo, 4Department of Morphology, Surgery and Experimental Medicine, Section of Obstetrics and Gynecology, Infertility Unit, University of Ferrara, Ferrara, Italy Abstract: Uterine fibroids are the most common benign tumors of the female genital tract. The management of symptomatic fibroids has traditionally been surgical; however, alternative pharmacological approaches have been proposed to control symptoms. To date, gonadotropin-releasing hormone analogs are the only available drugs for the preoperative treatment of fibroids. However, the US Food and Drug Administration recently authorized ulipristal acetate (UPA, an oral selective progesterone-receptor modulator, for the same indication. UPA is a new, effective, and well-tolerated option for the preoperative treatment of moderate and severe symptoms of uterine fibroids in women of reproductive age. According to clinical data, UPA shows several advantages: it is faster than leuprolide in reducing the fibroid-associated bleeding, it significantly improves hemoglobin and hematocrit levels in anemic patients, and it grants a significant reduction in the size of fibroids, which lasts for at least 6 months after the end of the treatment. Furthermore, UPA displays a better tolerability profile when compared to leuprolide; in fact, it keeps estradiol levels at mid follicular phase range, thereby reducing the incidence of hot flushes and exerting no impact on bone turnover. On the grounds of this evidence, the administration of 5 mg/day ulipristal acetate for 3 months is suggested for different patient categories and allows for planning a treatment strategy

  10. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Ethics and limitations to care”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Ethics and limitations to care”ABS 1. METHODS TO DERIVE UTILITIES FOR PEDIATRIC DISABILITY IN A DEVELOPING COUNTRY • E. Spiegel, I. Brajkovic, S. Jondhale, J. Partridge, V. Bhutani, P. KumarABS 2.UTILITIES FOR DISABILITY IN A DEVELOPING COUNTRY: PROVIDER PERSPECTIVES • S. Jondhale, E. Spiegel, I. Brajkovic, J. Partridge, V. Bhutani, P. KumarABS 3.LIMITING LIFE SUSTAINING TREATMENT FOR NEWBORN INFANTS: THE WILST STUDY • N. Aladangady, C. Shaw, K. Gallagher, E. Stokoe, N. Marlow for Collaborator GroupABS 4.NEONATAL ORGAN DONATION IN SCOTLAND • L. Leven, N. Healy, K. O’ReillyABS 5.GLOBAL PREVENTION OF Rh-SENSITIZATION: AN INTERACTIVE, COMMUNITY-CENTERED SOCIAL PLATFORM • A.R. Stark, J.Y. Hall, A. Zipursky, V.K. Bhutani

  11. Theoretical study of the mechanism and rate constant of the B + CO2 reaction.

    Science.gov (United States)

    Poully, Benjamin; Bergeat, Astrid; Hannachi, Yacine

    2008-09-04

    The different stationary points on the potential energy surface relative to the title reaction have been reinvestigated at the B3LYP/aug-cc-pVDZ level with relative energies computed at the CCSD(T)/aug-cc-pVTZ level with B3LYP/aug-cc-pVDZ optimized geometries and by using the G3B3 composite method. Two entrance channels have been identified. The first one corresponds to boron addition at one of the oxygen atoms of the CO 2 molecule leading to trans-BOCO, which is found to be about 27 kcal/mol exothermic with a potential energy barrier of 16.4 kcal/mol (G3B3). The second channel, which has not been identified in previous theoretical works, corresponds to a direct insertion of the boron atom into a CO bond and leads to OBCO. The B + CO 2 --> OBCO step is found to be about 84 kcal/mol exothermic and needs to overcome a potential energy barrier of only 3.6 kcal/mol (G3B3). The rate constant at 300 K of the insertion step, calculated by using TST theory with G3B3 calculated activation energy value, is 5.4 10 (-14) cm (3) molecule (-1) s (-1), in very good agreement with the experimental data ((7.0 +/- 2.8) 10 (-14) cm (3) molecule (-1) s (-1), DiGiuseppe, T. G.; Davidovits, P. J. Chem. Phys. 1981, 74, 3287). The one corresponding to the addition process is found to be several orders of magnitude smaller because of a much higher potential energy barrier. The addition channel would not contribute to the title reaction even at high temperature. A modified Arrhenius equation has been fitted in the 300-1000 K temperature range, which might be useful for chemical models.

  12. Candidate genes of Waldenström’s macroglobulinemia: current evidence and research

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    Bianchi G

    2013-07-01

    Full Text Available Giada Bianchi,1 Antonio Sacco,1 Shaji Kumar,2 Giuseppe Rossi,3 Irene Ghobrial,1 Aldo Roccaro11Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 2Division of Hematology, Mayo Clinic, Rochester, MN, USA; 3Department of Hematology, Spedali Civili di Brescia, Brescia, ItalyAbstract: Waldenström’s macroglobulinemia (WM is a relatively uncommon, indolent malignancy of immunoglobulin M-producing B cells. The World Health Organization classifies it as a lymphoplasmacytic lymphoma and patients typically present with anemia, hepatosplenomegaly and diffuse lymphadenopathies. Historically, the genetic characterization of the disease has been hampered by the relatively low proliferative rate of WM cells, thus making karyotyping challenging. The use of novel technologies such as fluorescence in situ hybridization, gene array, and whole genome sequencing has contributed greatly to establishing candidate genes in the pathophysiology of WM and to identifying potential treatment targets, such as L265P MYD88. The discovery of microRNAs and the recognition of epigenetics as a major modulatory mechanism of oncogene expression and/or oncosuppressor silencing have aided in further understanding the pathogenesis of WM. Once thought to closely resemble multiple myeloma, a cancer of terminally differentiated, immunoglobulin-secreting plasma cells, WM appears to genetically cluster with other indolent B-cell lymphomas such as chronic lymphocytic leukemia/small cell lymphoma. The relative high incidence of familial cases of WM and other B-cell malignancies has been helpful in identifying high-risk gene candidates. In this review, we focus on the established genes involved in the pathogenesis of WM, with special emphasis on the key role of derangement of the nuclear factor kappa B signaling pathway and epigenetic mechanisms.Keywords: genetics, familial cases, NF-κB, whole genome sequencing, MYD88

  13. Hallermann–Streiff syndrome with severe bilateral enophthalmos and radiological evidence of silent brain syndrome: a new congenital silent brain syndrome?

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    Nucci P

    2011-07-01

    Full Text Available Paolo Nucci¹, Carlo de Conciliis², Matteo Sacchi¹, Massimiliano Serafino¹¹Eye Clinic, San Giuseppe Hospital, University of Milan, ²Eye Clinic, Istituto Auxologico Italiano, Milan, ItalyBackground: We present the first case of a congenital form of silent brain syndrome (SBS in a young patient affected by Hallermann–Streiff syndrome (HSS and the surgical management of the associated eyelid anomalies.Methods: HSS signs were evaluated according to the Francois criteria. Orbital computed tomography (CT and genetic analysis were performed. An upper eyelid retractor-free recession was performed. Follow-up visits were performed at day 1, weeks 1 and 3, and months 3, 6, 9 (for both eyes, and 12 (for left eye after surgery.Results: The patient exhibited six of the seven signs of HSS. Orbital CT showed bilateral enophthalmos and upward bowing of the orbital roof with air entrapment under the upper eyelid as previously described for SBS. Genetic analysis showed a 2q polymorphism. During follow-up, the cornea showed absence of epithelial damage and the upper eyelids were lowered symmetrically, with a regular contour.Conclusion: Our HSS patient shares features with SBS. We postulate that SBS could include more than one pattern, ie, an acquired form following ventriculoperitoneal shunting and this newly reported congenital form in our HSS patient in whom typical syndromic skull anomalies led to this condition. The surgical treatment has been effective in restoring an appropriate lid level, with good globe apposition and a good cosmetic result.Keywords: Hallermann–Streiff syndrome, silent brain syndrome, upper eyelid entropion

  14. Italian neuropsychology in the second half of the twentieth century.

    Science.gov (United States)

    Vallar, Giuseppe; Boller, François; Grossi, Dario; Gainotti, Guido

    2015-03-01

    Since the early 1960s, human neuropsychology, the study of brain-behavior interrelations, mainly based on the analysis of their pathological variations, brought about by brain damage, has had a remarkable systematical development in Italy. All this started in Milan, with the neurologist Ennio de Renzi, and his collaborators (Luigi Vignolo, then Anna Basso, Pietro Faglioni, Hans Spinnler, François Boller, and, more autonomously, Edoardo Bisiach), in the Clinic of Nervous and Mental Diseases. Scientists of the "Milan group" investigated several neuropsychological deficits caused by focal hemispheric lesions in large series of left- and right-brain-damaged patients, and control participants, comparable for cultural and demographic variables. Standardized tests and advanced statistical methods were used, which also applied to the diagnosis and rehabilitation of aphasia. Subsequently, neuropsychology developed in Italy extensively, reaching high international reputation. Leading neuropsychologists have been the neurologists Guido Gainotti (Rome), and Franco Denes (Padua), the physicians and psychologists Luigi Pizzamiglio (Rome), and Carlo Umiltà (Parma, with fruitful interactions with the neurophysiologists Giovanni Berlucchi, Giacomo Rizzolatti, and Carlo Marzi, from the school of Giuseppe Moruzzi in Pisa) A second scientific generation of neuropsychologists has then developed in the 1970s, trained by the abovementioned scientists, further boosting and spreading high-level basic and applied research (diagnosis and rehabilitation of neuropsychological deficits of patients with brain damage or dysfunction throughout the life span, from childhood to the elderly). Available techniques include structural and functional imaging (CT, PET, SPET, MRI and fMRI Scans, DTI), electrophysiological recording (EEG, ERPs), non-invasive brain stimulation (TMS, tES), and their combined use.

  15. DCLK1 immunoreactivity in colorectal neoplasia

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    Bellows CF

    2012-04-01

    Full Text Available Giuseppe Gagliardi1, Monica Goswami1, Roberto Passera2, Charles F Bellows11Department of Surgery and Pathology, Tulane University, New Orleans, LA, USA; 2Division of Nuclear Medicine Azienda Ospedaliero-Universitaria San Giovanni Battista, Turin, ItalyIntroduction: Microtubule-associated doublecortin and CaM kinase-like-1 (DCLK1 is a novel candidate marker for intestinal stem cells. The aim of our study was to assess DCLK1 immunoreactivity in colorectal carcinogenesis and its correlation with prognosis.Methods: DCLK1 immunostaining was performed in colorectal tissue from 71 patients, including 18 adenomatous polyps, 40 primary adenocarcinomas, and 14 metastatic lesions. Each case was evaluated by a combined scoring method based on the intensity of staining (score 0–3 and the percentage of tissue staining positive (score 0–3. Immunoexpression for DCLK1 was considered as positive when the combined score was 2–6 and negative with a score of 0–1.Results: Overall, 14/18 (78% of polyps, 30/40 (75% of primary adenocarcinomas, and 7/14 (50% of distant metastases were positive for DCLK1. In adenomatous polyps and primary cancer there was no association between DCLK1 staining score and tumor pathology. However, after curative colorectal cancer resection, patients whose tumor had a high (≥5 combined staining score had increased cancer-specific mortality compared to patients with low (0–4 staining score (hazard ratio 5.89; 95% confidence interval: 1.22–28.47; P = 0.027.Conclusion: We found that DCLK1 is frequently expressed in colorectal neoplasia and may be associated with poor prognosis. Further studies are necessary to validate the use of DCLK1 as a prognostic marker.Keywords: DCLK1, DCAMKL-1, gastrointestinal stem cell, cancer stem cell, adenomatous polyps, liver metastasis, immunohistochemistry

  16. Pubblica sicurezza e tutela dell’autonomia confessionale. Riflessioni a partire dalla negazione delle pubbliche esequie per i mafiosi

    Directory of Open Access Journals (Sweden)

    Fabio Balsamo

    2016-12-01

    SOMMARIO: 1. La costante applicazione degli artt. 26-27 T.U.L.P.S. alle ipotesi di funerali di mafiosi – 2. Il caso dei funerali pubblici negati al boss Giuseppe Barbaro e la “protesta” del Parroco di Platì. Un’ipotesi di lesione dell’autonomia confessionale? – 3. L’imposizione di funerali in forma privata e la dimensione essenzialmente comunitaria del rito delle esequie nel diritto canonico – 4. La privazione delle esequie ecclesiastiche tra tutela dell’autonomia confessionale e potere di intervento dell’autorità di pubblica sicurezza – 5. La rilettura del dovere di reciproca collaborazione tra Stato e Chiesa alla luce del comune impegno contro le mafie. Alcune attuali criticità – 6. Verso nuovi confini del dovere di collaborazione: l’assunzione di un impegno comune di Stato e confessioni religiose contro il crimine organizzato. Public safety and protection of confessional autonomy. Reflections from the denial of public funerals for mobsters. ABSTRACT: Measures taken by Italian Quaestors in order to prohibit public funerals for mobsters have an impact also on decision-making autonomy recognized at the ecclesiastical authority by canon 1184 C.i.c. on the same field. The recent Catholic Church’s commitment against mafias requires that what is decided by public authorities to ensure the public policy and public safety must be observed together to the measures laid down by Canon Law, with the aim to avoid the risk of a conflict between Italian and Canon Law. That’s why it’s necessary to give new meaning to the cooperation principle that State and Catholic Church have decided to carry on since 1984. Lastly, it would be appreciated if a similar principle could be extended to all religious faiths in Italy, in order to improve the potential contribution of all religions in combating and preventing organized crime.

  17. Large-spot subthreshold transpupillary thermotherapy for chronic serous macular detachment

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    Giuseppe Lo Giudice

    2011-03-01

    Full Text Available Giuseppe Lo Giudice1, Valentina de Belvis2, Marco Tavolato1, Alessandro Galan11San Paolo Ophthalmic Center, San Antonio Hospital, Padova, Italy; 2Paediatric Low Vision Center, Paediatric Rare Eye Disease Center, Department of Paediatrics, University of Padova, ItalyPurpose: To report the effect of subthreshold transpupillary thermotherapy (TTT in treating serous detachment of the neurosensory retina secondary to chronic central serous chorioretinopathy (CCSC.Methods: Seven eyes from five patients with CCSC, persistent serous detachment of the neurosensory retina and a clinical course of between 12 and 60 months were treated. All eyes received large-spot TTT guided by indocyanine green angiography (ICGA. Subthreshold TTT was performed using an 810 nm diode laser with a spot size of 3.0 mm (power was set at 350 mW. Treatment was applied for 60 seconds to the areas of choroidal hyperfluorescence on ICGA.Results: The mean number of TTT sessions was 1.4 ± 0.5. All eyes were followed up for at least 6 months (mean 9.6 ± 3.2 standard deviation; range 6–12 months. The mean logarithm of the minimum angle of resolution best-corrected visual acuity was significantly better compared with baseline. All TTT-treated eyes had stable or improved vision (P < 0.001. Mean optical coherence tomography (OCT central foveal thickness was significantly lower in all patients (P < 0.001 compared with pretreatment OCT, with a reduction in subretinal fluid and resolution of serous detachment associated with anatomical fovea restoration. No patient had any treatment-related side effects.Conclusion: Modified subthreshold TTT appears to have a beneficial effect in treating patients with CCSC and persistent neurosensory detachment. The encouraging results and lack of visually significant complications suggest that further investigation is warranted.Keywords: central serous chorioretinopathy, indocyanine green angiography, neurosensory detachment, transpupillary

  18. The extension of Rome׳s Capitoline Museums and the design of a new Hall on the site of the ancient ‘Giardino Romano’

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    Raffaele Panella

    2015-09-01

    Full Text Available The new Hall of Marcus Aurelius in the Capitoline Museums, located within the ancient site of Giardino Romano, displays the original statue of the Roman emperor of the 2nd century AD. The idea of extending the Capitoline Museums by including this site came about in the framework of its general redevelopment.11 The chronology of the design work stretches from 1993 to 2002; the works have been achieved between 2004 and 2005. The design leader was Carlo Aymonino and his collaborators architects Maria Luisa Tugnoli, Geneviève Hanssen, Raffaella Castrignanò. The structural design is by engineer Antonio Michetti, with Giuseppe Silvetti and architect Marco Astolfi. The new Hall is the result of a long and complicated process (1988–2005 considering the exceptional importance of the site and the many changes brought to the museum programme during the said period (Figures 1 and 2.In fact, the new Hall was originally supposed to display the marbles of the Temple of Apollo Sosianus, the foundation wall of the Temple of Capitoline Jupiter, embedded within the structures of the Palazzo Caffarelli, opposite the Giardino Romano. However, in 1997, the plan for the Capitoline Museum changed radically as the statue of Marcus Aurelius, which had been restored following the blast of a bomb attack in 1979, was determined to be the focus of the Hall. The project finally consisted of a steel and glass structure on an elliptic plan andshaped around the foundations of the Temple, with the statue at its center.

  19. Battista Grassi entomologist and the Roman School of Malariology.

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    Capanna, E

    2008-12-01

    Grassi's entomological researches go back to his early years of university study, initially being concerned with agriculture pests. After working in Heidelberg, Grassi's interests turned to basic problems of entomology, such as the evolutionary origin of Miriapoda and Insecta, and termite caste determination. His first investigations into medical entomology related to the problem of bird malaria, which he studied only in relation to the hematic parasites. In 1895, Grassi was appointed Professor of Comparative Anatomy at Rome University, and initiated his entomological collaboration with the Roman malariologists, Amico Bignami, Giuseppe Bastianelli and Ettore Marchiafava. At the end of 1898, they announced, at the session of the Accademia dei Lincei on December 4th, that a healthy man in a non-malarial zone had contracted tertian malaria after being bitten by an experimentally infected Anopheles claviger. Following his disappointment at being excluded from the Nobel prize, Grassi devoted his attention to another important insect related to the transmission of parasitic disease, the sand fly, Phlebotomus papatasii. After World War I malaria had flared up with renewed vigour, so that the social importance of the disease convinced Grassi to resume his studies in 1918. The problem he faced in these years was "Anophelism without malaria" which was to be solved a year after his death by his pupil Falleroni, who demonstrated that there are six cryptic species of Anopheles of which only four bite humans and transmit malaria. Battista Grassi died on 4 May 1925, working to the end: he was reading the proofs of his last paper, Lezione sulla malaria.

  20. Potential drug–drug interactions in Alzheimer patients with behavioral symptoms

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    Pasqualetti G

    2015-09-01

    Full Text Available Giuseppe Pasqualetti, Sara Tognini, Valeria Calsolaro, Antonio Polini, Fabio Monzani Geriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Abstract: The use of multi drug regimens among the elderly population has increased tremendously over the last decade although the benefits of medications are always accompanied by potential harm, even when prescribed at recommended doses. The elderly populations are particularly at an increased risk of adverse drug reactions considering comorbidity, poly-therapy, physiological changes affecting the pharmacokinetics and pharmacodynamics of many drugs and, in some cases, poor compliance due to cognitive impairment and/or depression. In this setting, drug–drug interaction may represent a serious and even life-threatening clinical condition. Moreover, the inability to distinguish drug-induced symptoms from a definitive medical diagnosis often results in addition of yet another drug to treat the symptoms, which in turn increases drug–drug interactions. Cognitive enhancers, including acetylcholinesterase inhibitors and memantine, are the most widely prescribed agents for Alzheimer’s disease (AD patients. Behavioral and psychological symptoms of dementia, including psychotic symptoms and behavioral disorders, represent noncognitive disturbances frequently observed in AD patients. Antipsychotic drugs are at high risk of adverse events, even at modest doses, and may interfere with the progression of cognitive impairment and interact with several drugs including anti-arrhythmics and acetylcholinesterase inhibitors. Other medications often used in AD patients are represented by anxiolytic, like benzodiazepine, or antidepressant agents. These agents also might interfere with other concomitant drugs through both pharmacokinetic and pharmacodynamic mechanisms. In this review we focus on the most frequent drug–drug interactions, potentially harmful, in AD patients with

  1. Tolerability and camouflaging effect of corrective make-up for acne: results of a clinical study of a novel face compact cream

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    Monfrecola G

    2016-10-01

    Full Text Available Giuseppe Monfrecola, Sara Cacciapuoti, Claudia Capasso, Mario Delfino, Gabriella Fabbrocini Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy Background: A novel face compact cream (FCC containing a new patented formulation was recently developed to provide acne patients with cosmetic camouflage for their lesions and to have beneficial effects on the multifactorial components of the disease. This pilot investigation aimed to evaluate the real-life tolerability, potential for comedogenicity and covering effect provided by this FCC.Methods: This single-center study evaluated the FCC applied once daily for 28 days in 20 females with facial acne. Tolerability was assessed by rating skin reactions on a scale from 1 =absent to 4 =evident. Comedogenicity potential was evaluated by determining the number of facial acne lesions before and after use of the FCC. The covering effect was rated in ten patients 30 minutes after application on a scale from 1 =none to 5 =excellent. Patients rated their opinions on the FCC on day 28 using a questionnaire.Results: Assessment of tolerability on days 0, 14, and 28 showed that skin reactions, including erythema, edema, dryness, desquamation, tight feeling, itching, and burning, were absent in all patients. The FCC was noncomedogenic and provided a significant 15.8% reduction in facial acne lesions after 28 days (P<0.001. The FCC provided a good covering effect 30 minutes after application in 80% of patients. All patients (100% were satisfied with the FCC, with 90% agreeing that the FCC was effective and 80% stating that the FCC improved their skin.Conclusion: The FCC was positively perceived, well tolerated, noncomedogenic, and provided an effective covering of acne in this small group of female patients with 1 month of follow-up. Keywords: acne, comedones, dermatocosmetic, tolerability

  2. Management strategies in the treatment of neonatal and pediatric gastroenteritis

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    Ciccarelli S

    2013-10-01

    Full Text Available Simona Ciccarelli,1 Ilaria Stolfi,1 Giuseppe Caramia2 1Neonatal Intensive Care Unit, Sapienza University of Rome, Rome, Italy; 2Division of Neonatology and Pediatrics, Maternal and Child Hospital "G. Salesi", Ancona, Italy Abstract: Acute gastroenteritis, characterized by the onset of diarrhea with or without vomiting, continues to be a major cause of morbidity and mortality in children in mostly resource-constrained nations. Although generally a mild and self-limiting disease, gastroenteritis is one of the most common causes of hospitalization and is associated with a substantial disease burden. Worldwide, up to 40% of children aged less than 5 years with diarrhea are hospitalized with rotavirus. Also, some microorganisms have been found predominantly in resource-constrained nations, including Shigella spp, Vibrio cholerae, and the protozoan infections. Prevention remains essential, and the rotavirus vaccines have demonstrated good safety and efficacy profiles in large clinical trials. Because dehydration is the major complication associated with gastroenteritis, appropriate fluid management (oral or intravenous is an effective and safe strategy for rehydration. Continuation of breastfeeding is strongly recommended. New treatments such as antiemetics (ondansetron, some antidiarrheal agents (racecadotril, and chemotherapeutic agents are often proposed, but not yet universally recommended. Probiotics, also known as “food supplement,” seem to improve intestinal microbial balance, reducing the duration and the severity of acute infectious diarrhea. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition and the European Society of Paediatric Infectious Diseases guidelines make a stronger recommendation for the use of probiotics for the management of acute gastroenteritis, particularly those with documented efficacy such as Lactobacillus rhamnosus GG, Lactobacillus reuteri, and Saccharomyces boulardii. To date, the

  3. Science Fiction In Naples In The Middle Of The 19th Century

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    Capaccioli, Massimo; Cirella, Emilia Olostro; Stendardo, Enrica; Virgilio, Nicla

    Astronomer, intellectual, passionate patriot, and refined humanist, Ernesto Capocci Belmonte (Picinisco, May 31, 1798 - Naples, January 6, 1864) was a prominent figure of the scientific, cultural, and political life in Naples around the middle of the 19th century. He acquired international recognition for his studies on the orbits of comets and, since 1833, he was named director of the newly built Osservatorio Astronomico in Capodimonte: A prestigious position that he lost for political retaliation as a result of his participation in the movement against the Bourbon rulers in 1848, but which he regained in 1860 upon the arrival in Naples of Giuseppe Garibaldi. An intuitive and open-minded scholar, he looked always at the contemporary experiences in Europe and, as a scientist and cultivated human being, he sought to serve the community by enthusiastically devoting himself also to education and public outreach. He developed clear interests in literature and, as a forerunner, he dared to tackle the genre of science fiction. His short novel Relazione del viaggio alla Luna fatto da una donna nell'anno di grazia 2057 (Report of the Trip to the Moon done by a Woman in the Year of our Lord 2057), written in the period of his exile from the Observatory and practically given up as lost until a private copy was found in the library of one of Capocci's descendants, offers an interesting overview of astronomical knowledge and taste for the elegance in writing, and gives an unusual, and often ironic, viewpoint on the situation of sciences in Naples in the middle of the 19th century.

  4. Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro

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    de Peppo GM

    2014-05-01

    Full Text Available Giuseppe Maria de Peppo,1–3 Hossein Agheli,2,3 Camilla Karlsson,2,3 Karin Ekström,2,3 Helena Brisby,3,4 Maria Lennerås,2,3 Stefan Gustafsson,3,5 Peter Sjövall,3,5,6 Anna Johansson,2,3 Eva Olsson,3,5 Jukka Lausmaa,3,6 Peter Thomsen,2,3 Sarunas Petronis3,6 1The New York Stem Cell Foundation Research Institute, New York, NY, USA; 2Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, 3BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, 4Department of Orthopaedics, Sahlgrenska Academy, University of Gothenburg, 5Applied Physics, Chalmers University of Technology, Göteborg, Sweden; 6Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Borås, Sweden Background: Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role in the osseointegration of implantable devices. Methods: In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs. Results: We found that the proliferation and osteogenic differentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion. Conclusion: Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration. Keywords: colloidal lithography, nanotopography, human mesenchymal stem cells, cell proliferation, osteogenic

  5. Stroke in Renaissance time: the case of Francesco I de' Medici.

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    Arba, Francesco; Inzitari, Domenico; Barnett, Henry Joseph Macaulay; Lippi, Donatella

    2012-01-01

    Francesco I de' Medici (1541-1587), the second Grand Duke of Tuscany, was one of the members of the Medici family who ruled Florence during the centuries of the Renaissance. When, in 1857, all members of the Medici family were exhumed and definitively buried in the place where they still lie buried today, a painter, Giuseppe Moricci (Florence 1806-1879), who attended the ceremony, depicted the corpse of Francesco I in a perfect state of preservation. The painting shows a right spastic hemiparesis with a facial droop, a claw-hand appearance, the right shoulder internally rotated, the calf muscle wasted and the clubfoot confirmed by an orthopedic footwear in the coffin. The hemiparesis and consequent disability were likely concealed when Francesco I was alive, since in official portraits the Grand Duke appeared in perfect physical condition. However, chronicles reported that he had suffered from malaria and syphilis. Later in his life, temper and behavioral changes as well as emotional instability were documented, together with handwriting deterioration and seizures. We postulate that Francesco I had suffered from a stroke consequent to syphilis, a new aggressive and rapidly spreading infectious disease at that time in Italy. Francesco's governmental skills were presumably altered due to these diseases. Disability consequent to stroke was likely concealed by official portrayers and biographers of Francesco I during his life, consistent with the King's two bodies theory common since the Middle Ages: while the King's physical body is destined to die, the political one is everlasting. Infectious diseases have remained a leading cause of stroke in underdeveloped countries until recently, but noncommunicable causes are now prevailing worldwide.

  6. PREFACE: Particles and Fields: Classical and Quantum

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    Asorey, M.; Clemente-Gallardo, J.; Marmo, G.

    2007-07-01

    , Como, Italy INDURAIN, Javier: Universidad de Zaragoza, Spain KLAUDER, John: University of Florida, USA KOSSAKOWSKI, Andrzej: Nicolaus Copernicus University, Torun, Poland MARMO, Giuseppe: Università di Napoli Federico II, Italy MORANDI, Giuseppe: Universitá di Bologna-Italy MUKUNDA, Narasimhaiengar: Indian Institute of Science, Bangalore, India MUÑOZ-CASTAÑEDA, Jose M.: University of Zaragoza, Spain NAIR, RANJIT: Centre for Philosophy & Foundations of Science, New Delhi, India NILSSON, Jan S: University of Gothenburg, Sweden OKUBO, Susumu: University of Rochester, USA PASCAZIO, Saverio: Universitá di Bari, Italy RIVERA HERNÁNDEZ, Rayito: Université Pierre et Marie Curie, Paris, France RODRIGUEZ, Cesar: University of Texas - Austin, USA SCOLARICI, Giuseppe: Universitá del Salento, Lecce, Italy SEGUI, Antonio: Universidad de Zaragoza, Spain SHAPIRO, Ilya: Universidade Federal de Juiz de Fora, Brasil SIMONI, Alberto: Università di Napoli Federico II, Italy SOLOMON, Allan: Open University/ University of Paris VI, UK/France SUDARSHAN, Ashok: SUDARSHAN, George: University of Texas at Austin, USA TULCZYJEW, Wlodzimierz: Universitá di Camerino, Italy UCHIYAMA, Chikako: University of Yamanashi, Japan VENTRIGLIA, Franco: Università di Napoli Federico II, Italy VILASI, Gaetano: Universitá di Salerno, Italy ZACCARIA, Francesco: Universitá di Napoli Federico II, Italy

  7. Gender difference in response predictors after 1-year exenatide therapy twice daily in type 2 diabetic patients: a real world experience

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    Anichini R

    2013-04-01

    Full Text Available Roberto Anichini,1 Sabrina Cosimi,2 Alberto Di Carlo,3 Paola Orsini,4 Alessandra De Bellis,1 Giuseppe Seghieri,1 Flavia Franconi,5 Fabio Baccetti6 1Diabetes Unit, Spedali Riuniti, Pistoia, Italy; 2Diabetes Unit, Hospital of Versilia, Camaiore (LU, Italy; 3Diabetes Unit, Hospital of Lucca, Italy; 4Diabetes Unit, Hospital of Livorno, Italy; 5Department of Biochemical Sciences, University of Sassari, Italy; 6Diabetes Unit, Hospital of Massa, Italy Purpose: To investigate whether gender affects therapeutic response by exenatide twice a day (BID in type 2 diabetes by using a database concerning patients monitored by five outpatient clinics in Tuscany, Italy. Patients and methods: We considered a cohort of 315 (154 male/161 female patients experiencing therapeutic failure while on oral therapy (metformin, or combination therapy metformin + sulphonylureas, who were given exenatide (10 µg/BID and who fully completed 4 months, 8 months, and 12 months of follow-ups. Results: Among patients stratified by gender and well matched for age, body mass index, and hemoglobin A1c (HbA1c, it was found that the length of disease was longer in females than in males (12 ± 8 years versus 10 ± 7 years; P = 0.037, and the ratio of patients on metformin to those on combination therapy was higher in men (P = 0.018. Target glycemic response (1-year HbA1c ≤ 7% was achieved in a significantly higher proportion of males than females (38% versus 27%;Χ2 = 4.66; P = 0.03. Target weight loss expressed as 1-year weight percent fall from baseline ≥ 75th percentile (8.5% was significantly higher in females at 8 and 12 months (P < 0.05; for both. One-year glycemic target response was inversely related to baseline HbA1c levels and diabetes duration among males, while metformin therapy (compared to oral combination therapy was a significant predictor of better glycemic targets among females. Homeostasis model assessment-B, measured in 117 patients, predicted hypoglycemic

  8. Urinary protein profiles in ketorolac-associated acute kidney injury in patients undergoing orthopedic day surgery

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    Mariano F

    2017-09-01

    Full Text Available Filippo Mariano,1 Chiara Cogno,1 Fulvia Giaretta,2,3 Ilaria Deambrosis,2,3 Simona Pozza,4 Maurizio Berardino,5 Giuseppe Massazza,6 Luigi Biancone1,3 1Department of General and Specialist Medicine, Nephrology, Dialysis and Transplantation Unit, City of Health and Science, CTO Hospital, Turin, 2Department of General and Specialist Medicine, Laboratory of Nephrology and Immunopathology, City of Health and Science, Molinette Hospital, Turin, 3Department of Medical Sciences, University of Turin, Turin, 4Department of Radiology and Radiotherapy, CTO Radiology, City of Health and Science, CTO Hospital, Turin, 5Department of Anesthesiology and Intensive Care, Anesthesiology and Intensive Care 5, City of Health and Science, CTO Hospital, Turin, 6Department of Orthopedics and Traumatology, Week Hospital Unit, City of Health and Science, CTO Hospital, and University of Turin, Turin, Italy Background: Parenteral administration of ketorolac is very effective in controlling postoperative pain for orthopedic surgery. Ketorolac can induce clinically relevant renal alterations in elderly patients, whereas its short course is considered safe for young adults with normal preoperative renal function. In this study, of a cohort of young adults undergoing elective orthopedic day surgery, we sought cases complicated by readmission due to acute kidney injury (AKI.Patients and methods: Among 1397 young adults, aged 18–32 years who were admitted to undergo orthopedic day surgery from 2013 to 2015, four patients (0.29%, three males/one female treated in postprocedure with ketorolac (from 60 to 90 mg/day for 1–2 days were readmitted for suspected severe AKI. We evaluated functional outcome, urinary protein profiles and kidney biopsy (1 patient.Results: After day surgery discharge, they experienced gastrointestinal disturbances, flank pain and fever. Readmitted on post-surgery days 3–4, they presented with oliguric AKI (creatinine range 158.4–466.4 µmol/L and

  9. Efficacy and safety evaluation of pentoxifylline associated with other antioxidants in medical treatment of Peyronie's disease: a case-control study

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    Paulis G

    2015-12-01

    Full Text Available Gianni Paulis,1,2 Davide Barletta,3 Paolo Turchi,4 Antonio Vitarelli,5 Giuseppe Dachille,6 Andrea Fabiani,7 Romano Gennaro8 1Regina Apostolorum Hospital, Andrology Center, Albano L, 2Castelfidardo Medical Team, Peyronie's Disease Care Center, Rome, 3Department of Urology, Andrology Center, San Matteo Hospital, Pavia, 4Azienda ASL 4 Prato – Andrology Service, Prato, 5Department of Urology, University of Bari, 6Department of Urology, S Giacomo Hospital, Monopoli, Bari, 7Department of Surgery, Section of Urology and Andrology, Macerata, 8Department of Urologic Oncology, Section of Avellino, Italian League Against Cancer, Avellino, Italy Abstract: Peyronie's disease (PD is a chronic disorder involving the tunica albuginea surrounding the corpora cavernosa of the penis. A conservative treatment is indicated in the first stage of disease. The aim of this study was to assess the therapeutic impact and possible side effects of treatment with pentoxifylline (PTX in combination with other antioxidants in 307 patients with early-stage PD. Patients were subdivided into three groups: A, B, and C. Both groups, A and B, comprising of 206 patients, underwent treatment, whereas Group C was the control group (n=101. Treatment lasted 6 months and included the following: Group A: PTX 400 mg twice a day + propolis 600 mg/d + blueberry 160 mg/d + vitamin E 600 mg/d + diclofenac 4% gel twice/a day + PTX 100 mg via perilesional penile injection/every other week (12 injections in all; Group B: the same treatment as Group A except for the penile PTX injections. After the 6-month treatment course, we obtained the following results: actual mean decrease in plaque volume -46.9% and -24.8% in Group A and B, respectively (P<0.0001; mean curvature reduction -10.1° and -4.8°, respectively (P<0.0001; resolution of pain in 67.6% and 67.2% of cases, respectively (P=0.961; recovery of normal penile rigidity in 56.09% and 23.5% of cases, respectively (P=0.005. After 6 months

  10. Cardiovascular risk evaluation and prevalence of silent myocardial ischemia in subjects with asymptomatic carotid artery disease

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    Ciccone M

    2011-03-01

    Full Text Available Marco Matteo Ciccone1, Artor Niccoli-Asabella2, Pietro Scicchitano1, Michele Gesualdo1, Antonio Notaristefano2, Domenico Chieppa1, Santa Carbonara1, Gabriella Ricci1, Marco Sassara1, Corinna Altini2, Giovanni Quistelli1, Mario Erminio Lepera1, Stefano Favale1, Giuseppe Rubini21Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO, 2Nuclear Medicine Unit, Department of Internal Medicine and of Public Medicine, University of Bari, Bari, ItalyIntroduction: Silent ischemia is an asymptomatic form of myocardial ischemia, not associated with angina or anginal equivalent symptoms, which can be demonstrated by changes in ECG, left ventricular function, myocardial perfusion, and metabolism. The aim of this study was to evaluate the prevalence of silent myocardial ischemia in a group of patients with asymptomatic carotid stenosis.Methods: A total of 37 patients with asymptomatic carotid plaques, without chest pain or dyspnea, was investigated. These patients were studied for age, sex, hypertension, diabetes, dyslipidemia, smoking, and family history of cardiac disease, and underwent technetium-99 m sestamibi myocardial stress-rest scintigraphy and echo-color Doppler examination of carotid arteries.Results: A statistically significant relationship (P = 0.023 was shown between positive responders and negative responders to scintigraphy test when both were tested for degree of stenosis. This relationship is surprising in view of the small number of patients in our sample. Individuals who had a positive scintigraphy test had a mean stenosis degree of 35% ± 7% compared with a mean of 44% ± 13% for those with a negative test. Specificity of our detection was 81%, with positive and negative predictive values of 60% and 63%, respectively.Conclusion: The present study confirms that carotid atherosclerosis is associated with coronary atherosclerosis and highlights the importance of screening for ischemic heart disease in

  11. El partisano Johnny (novela, fragmento

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    Beppe Fenoglio

    2013-07-01

    Full Text Available GIUSEPPE "BEPPE" FENOGLIO (Alba, 1922 – Turín, 1963. Hijo primogénito de una familia de tres hijos, Beppe nació en Alba en las Langhe el 1 de marzo 1922. En 1940 se inscribe en la facultad de Letras de la Universidad de Turín, en la que estuvo hasta 1943, momento en el que fue reclutado por el ejército y mandado primero a Ceva (Cuneo y después a Pietralata (Roma, donde realizó la instrucción militar. Tras el abandono que siguió al 8 de septiembre de 1943, Fenoglio se une primero en enero de 1944 a las formaciones partisanas. En un primer momento se enrola con los "rojos" de las Brigadas Garibaldi, pero pronto se une a los badogliani en el 1º Gruppo Divisioni Alpine comandado por Enrico Martini "Mauri" y en la 2ª Divisione Langhe comandada por Piero Balbo que operaba en las Langhe, entre Mango, Murazzano y Mombarcaro. En 1949 inicia con su primer cuento, Il trucco, una breve pero fundamental carrera literaria que se afirmará al año siguiente, cuando entre en contacto con el grupo de autores reunidos en torno a la editorial Einaudi, dando a la luz títulos de la altura de Racconti della guerra civile, La paga del sabato, I ventitré giorni della città di Alba o Primavera di belleza. A finales de 1959 se le diagnostica una grave enfermedad respiratoria que se complicará a lo largo de los tres años siguientes y que le causará la muerte en febrero de 1963. De la obra culmen de su carrera, la póstuma Il partigiano Johnny, ofrecemos las páginas iniciales con la estupenda traducción de Pepa Linares, recientemente publicada en castellano por Sajalín Editores. Normal 0 21 false false false ES X-NONE X-NONE  

  12. Etiology of hypercoagulable state in women with recurrent fetal loss without other causes of miscarriage from Southern Italy: new clinical target for antithrombotic therapy

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    Maristella D’Uva

    2008-10-01

    Full Text Available Maristella D’Uva1, Pierpaolo Di Micco2, Ida Strina1, Antonio Ranieri1, Carlo Alviggi1, Antonio Mollo1, Francesca Fabozzi1, Lucia Cacciapuoti1, Maria Teresa Scotto di Frega1, Mariateresa Iannuzzo2, Giuseppe De Placido11Dipartimento Universitario di Scienze Ostetriche Ginecologiche e Medicina della Riproduzione, Area Funzionale di Medicina della Riproduzione ed Endoscopia Ginecologica, Università degli Studi di Napoli Federico II, via Pansini 5 Building 9, 80131, Naples, Italy; 2Internal Medicine Division, Fatebenefratelli Hospital of Naples, Naples, ItalyBackground: Recurrent fetal loss (RPL is one of the most common cause of sterility. Several studies identified thrombophilia as the principal cause of recurrent pregnancy loss. However, reported studies often do not evaluate other causes of miscarriages in their inclusion and exclusion criteria. So the aim of our study was to investigate the role of inherited thrombophilia in patients with RPL and without other causes of RPL.Patients and methods: Patients with 2 or more first trimester abortion or with 1 or more late pregnancy loss were considered for this study. In order to evaluate the causes of RPL we looked for chromosomal, endocrine, chronic inflammatory, and infectious alterations. 90 patients affected by unexplained RPL were enrolled and tested for hemostatic alterations. These women were tested for inherited and/or acquired thrombophilia by MTHFR C677T gene polymorphism, factor V Leiden gene polymorphism, PTHRA20210G gene polymorphism, protein S deficiency, protein C deficiency, antithrombin III deficiency, lupus anticoagulant, and anticardiolipin antibodies Ig G and Ig M.Results: Acquired and/or inherited thrombophilia are strongly associated with RPL when other common causes of miscarriage were excluded. 78% of tested women showed hemostatic abnormalities. Several women with combined thrombophilic defects were also identified by our data.Conclusion: After a thorough evaluation of

  13. Reavaliação da Suposta Ocorrência de Ornithischia na Formação Santana (Cretáceo Inferior, Bacia do Araripe, Nordeste, Brasil.

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    Elaine Batista Machado

    2007-07-01

    Full Text Available Em 1981, Giuseppe Leonardi e GuidoBorgomanero reportaram a primeira evidênciaosteológica da presença de dinossauros na Baciado Araripe. Estes pesquisadores identificaram umosso isolado como sendo um possível ísquio deOrnithischia, na época o primeiro registro desteclado em depósitos brasileiros. O material emquestão foi encontrado em 1978 em terrenos daFormação Santana, preservado em um nódulocalcário de coloração escura do Membro Romualdo,e estava guardado nas coleções Borgomanero (sobo número CB-PV-F-089. Com a morte de GuidoBorgomanero, o material foi doado pela viúvaRagnhild Borgomanero ao Museu Nacional(MN 7021-V.Ao descreverem o material, os autores nãohaviam preparado este exemplar completamente,e um lado estava totalmente coberto pela rochasedimentar. A preparação deste osso acaba de serfinalizada, e permitiu que o mesmo fosse identificadocom segurança como sendo uma costela do ladoesquerdo. O tamanho total preservado é de 32 cm(35 cm seguindo a curvatura. A parte proximalé expandida, com o capitulum e o tuberculumincompletos. A parte distal é mais fina, indicandoque se trata de uma costela de pequenas dimensões.Na superfície postero-medial este material exibe umaconcavidade que termina num forâmen pneumático.Apesar de poder ser identificado como umacostela reptiliana, a sua classificação dentro deReptilia é dificultada por ter sido encontrada isolada.Na Formação Santana foram identificados restosde Pterosauria, Crocodylomorpha e Theropoda.MN 7021-V difere das costelas de pterossauros,que possuem parede óssea bem fina e não são tãorobustos. O seu tamanho e curvatura também diferemdas costelas da maior parte dos crocodilomorfos.A morfologia geral de MN 7021-V se assemelhacom costelas de dinossauros terópodes, levando aclassificação deste material como Theropoda indet.Desta forma, a ocorrência de material osteológicode Ornithischia em depósitos do Cretáceo brasileiropermanece desconhecida at

  14. Drawing rocks at primary school: a tool for emerging misconceptions and promoting conceptual change

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    Benciolini, L.; Muscio, G.

    2012-04-01

    Drawing rocks at primary school: a tool for emerging misconceptions and promoting conceptual change Luca Benciolini Dipartimento di Fisica, Chimica e Ambiente, Università di Udine (Italy) and Giuseppe Muscio Museo Friulano di Storia Naturale (Udine, Italy) In order to investigate spontaneous ideas of children about rock samples, the Museo Friulano di Storia Naturale in collaboration with the Università di Udine submitted six classrooms of fifth and fourth grade-students to a specific test. One hundred thirty-three students without a specific background in Earth Sciences were asked to give a) a written description of a rock sample; b) a drawing of the sample; c) a written short story about the sample. The selected thirty-five samples in the opinion of the researchers contain 255 geologically relevant self-evident characters such as fossils, clastic textures, planar discontinuities and so on. Childs spontaneously described 209 geological characters. Forty-seven fifth-grade students (group A) have been previously followed specific training in multisensory description of objects and observed the 90% of the geologically relevant characters. Group B (forty-three fifth-grade) and group C (forty-three fourth-grade) on the contrary, without any previous instructions discovered the 77%. In order to follow childs building their knowledge through experience we found that the main problem was the lack of consistency between written and drawing description. Heterogeneities as evident as a magmatic contact have been correctly represented by the drawing but it has not been worth of any attention in the written description. On the contrary, written description may sometimes contain careful description of the clastic sedimentary process but these criteria are applied for example to a travertine, without any relations with observed characters. Descriptions and drawing of rock outcrops performed by university students demonstrate the persistence of this attitude. Thus, groups B and

  15. Flight mechanics applications for tethers in space: Cooperative Italian-US programs

    Science.gov (United States)

    Bevilacqua, Franco; Merlina, Pietro; Anderson, John L.

    1990-01-01

    Since the 1974 proposal by Giuseppe Colombo to fly a tethered subsatellite from the Shuttle Orbiter, the creative thinking of many scientists and engineers from Italy and U.S. has generated a broad range of potential tether applications in space. Many of these applications have promise for enabling innovative research and operational activities relating to flight mechanics in earth orbit and at suborbital altitudes. From a flight mechanics standpoint the most interesting of the currently proposed flight demonstrations are: the second Tethered Satellite System experiment which offers both the potential for aerothermodynamics and hypersonics research and for atmospheric science research; the Tethered Initiated Space Recovery System which would enable orbital deboost and recovery of a re-entry vehicle and waste removal from a space station; and the Tether Elevator/Crawler System which would provide a variable microgravity environment and space station center of mass management. The outer atmospheric and orbital flight mechanics characteristics of these proposed tether flight demonstrations are described. The second Tethered Satellite System mission will deploy the tethered satellite earthward and will bring it as low as 130 km from ground and thus into the transition region between the atmosphere (non-ionized) and the partially ionized ionosphere. The atmospheric flight mechanics of the tethered satellite is discussed and simulation results are presented. The Tether Initiated Space Recovery System experiment will demonstrate the ability of a simple tether system to deboost and recover a reentry vehicle. The main feature of this demonstration is the utilization of a Small Expendable Deployment System (SEDS) and the low-tension deployment assumed to separate the reentry vehicle from the Shuttle. This low-tension deployment maneuver is discussed and its criticalities are outlined. The Tether Elevator/Crawler System is a new space element able to move in a controlled way

  16. Pressure injuries in elderly with acute myocardial infarction

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    Komici K

    2017-09-01

    Full Text Available Klara Komici,1 Dino F Vitale,2 Dario Leosco,1 Angela Mancini,1 Graziamaria Corbi,3 Leonardo Bencivenga,1 Alessandro Mezzani,4 Bruno Trimarco,5 Carmine Morisco,5 Nicola Ferrara,1,2 Giuseppe Rengo1,2 1Division of Geriatrics, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy; 2Cardiac Rehabilitation Division, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme (BN, Telese Terme, Italy; 3Department of Medicine and Health Sciences, University of Molise Campobasso, Campobasso, Italy; 4Cardiac Rehabilitation Division, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Veruno, Veruno, Italy; 5Division of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy Objectives: To assess pressure injury (PI incidence among patients hospitalized for acute myocardial infarction (AMI in an intensive coronary care unit (ICCU and to detect the impact of specific risk factors on the development of PI in this clinical setting.Patients and methods: Prospective cohort study in ICCU setting. Patients admitted for AMI: patients mean age 67.5±11.5 years (n=165. Norton Scale, Mini Nutritional Assessment (MNA, demographic, clinical and biochemical data collected at the time of ICCU admission have been tested in a logistic model to assess the odds ratios (ORs of PI risk development. The jackknifed area under the receiver operating characteristic curve (AUC and the decision curve analysis have been employed to assess the additive predictive value of a factor.Results: Twenty-seven (16.3% patients developed PIs. An increased PI risk was associated with advanced age (OR =2.5 every 10-year increase; 95% CI =1.1–5.7, while probability of PI development was reduced in patients with higher left ventricular ejection fraction (LVEF (OR =0.4 every 5% increase; 95% CI =0.24–0.66, MNA score (OR =0.65 every unit change; 95% CI =0.44–0.95 and Norton Scale score

  17. Biocompatibility, endocytosis, and intracellular trafficking of mesoporous silica and polystyrene nanoparticles in ovarian cancer cells: effects of size and surface charge groups

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    Ekkapongpisit M

    2012-07-01

    Full Text Available Maneerat Ekkapongpisit,1 Antonino Giovia,1 Carlo Follo,1 Giuseppe Caputo,2,3 Ciro Isidoro11Laboratory of Molecular Pathology and Nanobioimaging, Department of Health Sciences, Università del Piemonte Orientale “A Avogadro”, Novara, 2Dipartimento di Chimica dell’Università di Torino, Torino, 3Cyanine Technology SpA, Torino, ItalyBackground and methods: Nanoparticles engineered to carry both a chemotherapeutic drug and a sensitive imaging probe are valid tools for early detection of cancer cells and to monitor the cytotoxic effects of anticancer treatment simultaneously. Here we report on the effect of size (10–30 nm versus 50 nm, type of material (mesoporous silica versus polystyrene, and surface charge functionalization (none, amine groups, or carboxyl groups on biocompatibility, uptake, compartmentalization, and intracellular retention of fluorescently labeled nanoparticles in cultured human ovarian cancer cells. We also investigated the involvement of caveolae in the mechanism of uptake of nanoparticles.Results: We found that mesoporous silica nanoparticles entered via caveolae-mediated endocytosis and reached the lysosomes; however, while the 50 nm nanoparticles permanently resided within these organelles, the 10 nm nanoparticles soon relocated in the cytoplasm. Naked 10 nm mesoporous silica nanoparticles showed the highest and 50 nm carboxyl-modified mesoporous silica nanoparticles the lowest uptake rates, respectively. Polystyrene nanoparticle uptake also occurred via a caveolae-independent pathway, and was negatively affected by serum. The 30 nm carboxyl-modified polystyrene nanoparticles did not localize in lysosomes and were not toxic, while the 50 nm amine-modified polystyrene nanoparticles accumulated within lysosomes and eventually caused cell death. Ovarian cancer cells expressing caveolin-1 were more likely to endocytose these nanoparticles.Conclusion: These data highlight the importance of considering both the

  18. The Properties of Fragments from Catastrophic Disruption Events

    Science.gov (United States)

    Giblin, I.; Martelli, G.; Farinella, P.; Paolicchi, P.; Di Martino, M.; Smith, P. N.

    1998-07-01

    We report and discuss the results from a series of catastrophic disruption experiments involving 21-cm spherical targets of alumina cement. These experiments were performed in the open air using a contact charge technique to simulate an impact at ∼6 km/s, typical of collision velocities between asteroids in the main belt. The 1992 experiments reported here, the most recent in an extensive experimental program initiated by Giuseppe Martelli before his death in 1994, follow directly from those described in I. Giblinet al.(1994a,Icarus110, 203-224), with a number of improvements to our instrumentation and analysis. By using two high-speed cameras at a mutual angle of 60° we have made possible a three-dimensional analysis of fragment velocities alongside the standard size, shape, ejection angle and rotation rate measurements which can easily be made from appropriately oriented single film records. In this paper we report on the results of the 1992 experiments, together with various unpublished data from 1989. We make a comparison between these sets of data and between our data and those of other researchers in this field. Also, we compare our results to those of the most recent semi-empirical model (SEM) of P. Paolicchiet al.(1996,Icarus121, 126-157) and to appropriate data concerning real asteroids, focusing on the dynamical families, which are believed to be remnants from the catastrophic disruption of precursor asteroids. A secondary purpose of this paper is to document our experiences and techniques in the implementation and analysis of these experiments. We find considerable variation in the slope of the fragment size distribution, even between closely similar experiments. Fragments are found to be slightly flatter and/or more elongated than those from some previous work, but in agreement with the previous study mentioned above. Fragment velocities are generally between 4 and 20 m/s with a few fast fragments observed up to 35 m/s. Only a weak correlation is

  19. Effects of low-carbohydrate diet therapy in overweight subject with autoimmune thyroiditis: possible synergism with ChREBP

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    Esposito T

    2016-09-01

    Full Text Available Teresa Esposito,1,2 Jean Marc Lobaccaro,3 Maria Grazia Esposito,4 Vincenzo Monda,1 Antonietta Messina,1 Giuseppe Paolisso,5 Bruno Varriale,2 Marcellino Monda,1 Giovanni Messina1,6 1Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, 2Laboratory of Molecular Biology and Genetics, Department of Experimental Medicine, Second University of Naples, Naples, Italy; 3UMR, Clermont Université, Centre de Recherche en Nutrition Humaine d’Auvergne, Aubière Cedex, France; 4Complex Surgery Unit, Evangelic Hospital Villa Betania, 5Department of Scienze Mediche, Chirurgiche, Neurologiche, Metaboliche e dell’Invecchiamento, Second University of Naples, Naples, 6Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy Abstract: The thyroid is one of the metabolism regulating glands. Its function is to determine the amount of calories that the body has to burn to maintain normal weight. Thyroiditides are inflammatory processes that mainly result in autoimmune diseases. We have conducted the present study in order to have a clear picture of both autoimmune status and the control of body weight. We have evaluated the amount of either thyroid hormones, or antithyroid, or anti-microsomal, or anti-peroxidase antibodies (Abs in patients with high amounts of Abs. In a diet devoid of carbohydrates (bread, pasta, fruit, and rice, free from goitrogenic food, and based on body mass index, the distribution of body mass and intracellular and extracellular water conducted for 3 weeks gives the following results: patients treated as above showed a significant reduction of antithyroid (-40%, P<0.013, anti-microsomal (-57%, P<0.003, and anti-peroxidase (-44%, P<0,029 Abs. Untreated patients had a significant increase in antithyroid (+9%, P<0.017 and anti-microsomal (+30%, P<0.028 Abs. Even the level of anti-peroxidase Abs increased without reaching statistical significance (+16%, P>0064

  20. Volumetric modulated arc therapy for treatment of solid tumors: current insights

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    Macchia G

    2017-07-01

    Full Text Available Gabriella Macchia,1 Francesco Deodato,1 Savino Cilla,2 Silvia Cammelli,3 Alessandra Guido,3 Martina Ferioli,3 Giambattista Siepe,3 Vincenzo Valentini,4 Alessio Giuseppe Morganti,3,* Gabriella Ferrandina5,6,* 1Radiation Oncology Unit, 2Medical Physics Unit, “Giovanni Paolo II” Foundation, Catholic University of the Sacred Heart, Campobasso, 3Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, 4Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, 5Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, 6Department of Health Sciences and Medicine, University of Molise, Campobasso, Italy *These authors contributed equally to this work Aim: This article discusses the current use of volumetric modulated arc therapy (VMAT techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is also reported.Materials and methods: All published manuscripts reporting the use of VMAT in a clinical setting from 2009 to November 2016 were identified. The search was carried out in December 2016 using the National Library of Medicine (PubMed/Medline. The following words were searched: “volumetric arc therapy”[All Fields] OR “vmat”[All Fields] OR “rapidarc”[All Fields], AND “radiotherapy”[All Fields] AND “Clinical Trial”[All Fields].Results: Overall, 37 studies (21 prospective and 16 retrospective fulfilling inclusion criteria and thus included in the review evaluated 2,029 patients treated with VMAT; of these patients, ~30.8% had genitourinary (GU tumors (81% prostate, 19% endometrial, 26.2% head-and-neck cancer (H&NC, 13.9% oligometastases, 11.2% had anorectal cancer, 10.6% thoracic neoplasms (81% breast, 19% lung, and 7

  1. Long-term survival in elderly patients with a do-not-intubate order treated with noninvasive mechanical ventilation

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    Riario-Sforza GG

    2011-04-01

    Full Text Available Paolo Scarpazza1, Cristoforo Incorvaia2, Paolo Amboni3, Giuseppe di Franco1, Stefania Raschi1, Pierfranco Usai1, Monica Bernareggi1, Cristiano Bonacina1, Chiara Melacini1, Roberta Cattaneo1, Serena Bencini1, Chiara Pravettoni2, Gian Galeazzo Riario-Sforza2, Gianni Passalacqua4, Walter Casali11Divisione di Broncopneumotisiologia, Ospedale Civile, Vimercate, Italy; 2Pulmonary Rehabilitation, Istituti Clinici di Perfezionamento, Milan, Italy; 3Clinical Chemistry Laboratory, Ospedali Riuniti, Bergamo, Italy; 4Allergy and Respiratory Diseases, University Of Genoa, Genoa, ItalyBackground: Noninvasive mechanical ventilation (NIMV is an effective tool in treating patients with acute respiratory failure (ARF, since it reduces both the need for endotracheal intubation and the mortality in comparison with nonventilated patients. A particular issue is represented by the outcome of NIMV in patients referred to the emergency department for ARF and with a do-not-intubate (DNI status because of advanced age or excessively critical conditions. This study evaluated long-term survival in a group of elderly patients with acute hypercapnic ARF who had a DNI order and who were successfully treated by NIMV.Methods: The population consisted of 54 patients with a favorable outcome after NIMV for ARF. They were followed up for 3 years by regular control visits, with at least one visit every 4 months, or as needed according to the patient’s condition. Of these, 31 continued NIMV at home and 23 were on long-term oxygen therapy (LTOT alone.Results: A total of 16 of the 52 patients had not survived at the 1-year follow-up, and another eight patients died during the 3-year observation, with an overall mortality rate of 30.8% after 1 year and 46.2% after 3 years. Comparing patients who continued NIMV at home with those who were on LTOT alone, 9 of the 29 patients on home NIMV died (6 after 1 year and 3 after 3 years and 15 of the 23 patients on LTOT alone died (10 after 1

  2. Reduction of group A beta-hemolytic streptococcus pharyngo-tonsillar infections associated with use of the oral probiotic Streptococcus salivarius K12: a retrospective observational study

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    Gregori G

    2016-01-01

    Full Text Available Giuseppe Gregori,1 Ornella Righi,1 Paolo Risso,2 Goffreda Boiardi,1 Giovanni Demuru,1 Anna Ferzetti,1 Antonio Galli,1 Marco Ghisoni,1 Sonia Lenzini,1 Claudio Marenghi,1 Caterina Mura,1 Roberto Sacchetti,1 Lucia Suzzani1 1Primary Care Department, Local Health Unit (ASL, Piacenza, 2Department of Health Science (DISSAL, University of Genoa, Genoa, Italy Abstract: Recurrent pharyngo-tonsillar infections caused by group A beta-hemolytic streptococci (GABHS occur frequently in young children, and the treatment of these infections contributes substantially to the total current requirement for antibiotic prescribing. Our study goal was to assess through a retrospective observational analysis whether the administration of the oral probiotic, Streptococcus salivarius K12 (SsK12, could reduce the occurrence of GABHS pharyngo-tonsillar infections in children who had a recent history of recurrent episodes of these infections. Twelve primary care pediatricians identified, through their databases, a total of 130 children who had experienced recurrent GABHS pharyngo-tonsillar infections over a period of at least 6–12 months prior to their inclusion in the study. Of these children, 76 then undertook a 90-day program requiring once-a-day dosing with a commercially available (Bactoblis lozenge containing SsK12. No probiotic supplement was given to the remaining 54 (control children. Each subject was monitored for the occurrence of GABHS pharyngo-tonsillitis and also for acute otitis media, bronchitis, sinusitis, and bronchopneumonia for at least 12 months following their entry to the study. Even 9 months after the use of SsK12 had been stopped, the probability of new GABHS infections was significantly lower (P>0.001 when compared to the period before dosing commenced. When compared to the untreated children, those taking SsK12 appear to have had significantly fewer GABHS infections both during the 90-day period of prophylaxis and during the following 9

  3. Depressive symptoms in Parkinson’s disease and in non-neurological medical illnesses

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    Assogna F

    2013-03-01

    Full Text Available Francesca Assogna,1 Sabrina Fagioli,1 Luca Cravello,1 Giuseppe Meco,2 Mariangela Pierantozzi,3 Alessandro Stefani,3 Francesca Imperiale,2 Carlo Caltagirone,1,3 Francesco E Pontieri,4 Gianfranco Spalletta11I.R.C.C.S. Santa Lucia Foundation, Rome, Italy; 2Department of Neurology and Psychiatry (Parkinson’s Centre and Research Centre of Social Diseases (CIMS, University “Sapienza”, Rome, Italy; 3Department of Neuroscience, University “Tor Vergata”, Rome, Italy; 4Department of Neuroscience, Mental Health and Sensory Systems, University “Sapienza”, Movement Disorder Unit, Sant’Andrea Hospital, Rome, ItalyBackground: Patients with neurological and non-neurological medical illnesses very often complain of depressive symptoms that are associated with cognitive and functional impairments. We compared the profile of depressive symptoms in Parkinson’s disease (PD patients with that of control subjects (CS suffering from non-neurological medical illnesses.Methods: One-hundred PD patients and 100 CS were submitted to a structured clinical interview for identification of major depressive disorder (MDD and minor depressive disorder (MIND, according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR, criteria. The Hamilton Depression Rating Scale (HDRS and the Beck Depression Inventory (BDI were also administered to measure depression severity.Results: When considering the whole groups, there were no differences in depressive symptom frequency between PD and CS apart from worthlessness/guilt, and changes in appetite reduced rates in PD. Further, total scores and psychic and somatic subscores of HDRS and BDI did not differ between PD and CS. After we separated PD and CS in those with MDD, MIND, and no depression (NODEP, comparing total scores and psychic/somatic subscores of HDRS and BDI, we found increased total depression severity in NODEP PD and reduced severity of the psychic symptoms of

  4. Dose-response curve to salbutamol during acute and chronic treatment with formoterol in COPD

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    La Piana GE

    2011-07-01

    Full Text Available Giuseppe Emanuele La Piana¹, Luciano Corda², Enrica Bertella¹, Luigi Taranto Montemurro¹, Laura Pini¹, Claudio Tantucci¹¹Cattedra di Malattie dell'Apparato Respiratorio, Università di Brescia, ²Prima Divisione di Medicina Interna, Spedali Civili, Brescia, ItalyBackground: Use of short-acting ß2-agonists in chronic obstructive pulmonary disease (COPD during treatment with long-acting ß2-agonists is recommended as needed, but its effectiveness is unclear. The purpose of this study was to assess the additional bronchodilating effect of increasing doses of salbutamol during acute and chronic treatment with formoterol in patients with COPD.Methods: Ten patients with COPD underwent a dose-response curve to salbutamol (until 800 µg of cumulative dose after a 1-week washout (baseline, 8 hours after the first administration of formoterol 12 µg (day 1, and after a 12-week and 24-week period of treatment with formoterol (12 µg twice daily by dry powder inhaler. Peak expiratory flow, forced expiratory volume in one second (FEV1, forced vital capacity, and inspiratory capacity were measured at the different periods of treatment and at different steps of the dose-response curve.Results: Despite acute or chronic administration of formoterol, maximal values of peak expiratory flow, FEV1, and forced vital capacity after 800 µg of salbutamol were unchanged compared with baseline. The baseline FEV1 dose-response curve was steeper than that at day 1, week 12, or week 24 (P < 0.0001. Within each dose-response curve, FEV1 was different only at baseline and at day 1 (P < 0.001, when FEV1 was still greater at 800 µg than at 0 µg (P < 0.02. In contrast, the forced vital capacity dose-response curves were similar at the different periods, while within each dose-response curve, forced vital capacity was different in all instances (P < 0.001, always being higher at 800 µg than at 0 µg (P < 0.05.Conclusion: In patients with stable COPD, the maximal effect

  5. Spazio pubblico e coscienza individuale: l’espansione del penalmente rilevante nel diritto canonico e nel diritto ecclesiastico

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    Salvatore Berlingò

    2014-02-01

    Full Text Available Il contributo, accettato dal Direttore, riproduce il testo, rivisto e integrato, con le note aggiornate, della relazione al Convegno Nazionale dell’ADEC sul tema “Per una disciplina che cambia. Il diritto canonico e il diritto ecclesiastico nel tempo presente” (Bologna, 7-9 novembre 2013, ed è destinato alla pubblicazione negli Atti del Convegno e alla Raccolta di scritti in onore di Giuseppe Dalla Torre.  SOMMARIO: 1. Privata libertà di coscienza ed ethos sociale collettivo - 2. La libertà di formazione della coscienza - 3. Gli indirizzi giurisprudenziali a sostegno del pluralismo culturale e religioso. - 4. Il penalmente rilevante nel diritto canonico - 5.Salus animarum e sanzioni penali canoniche - 6. La normativa penale vaticana e i suoi riflessi nell’ordinamento della Chiesa - 7. Il processo di riforma del diritto penale canonico - 8. Il principio di legalità e la tutela dell’umana dignità di tutti i fedeli - 9. Per una lettura il più possibile sostanziale e dinamica della legalità in ambito canonico e in ambito civile.  Public space and the individual conscience: the expansion of the act criminally considerable in canon and ecclesiastical law.  ABSTRACT: The autonomous existence of religious groups is an essential and constitutive element of public space as an irreplaceable sustenance for the pluralism in a democratic society and for the empowerment of a synthesis of values shared by all and continually in progress.It is necessary, however, that all groups use a legal language or, like this one rationally understandable; and therein the Catholic Church can take advantage of the tools offered by the canonistic tradition.Therefore, the comparison between the most recent developments of the canonical law in criminal matters and those recorded in parallel by the criminal law of the State, may be useful, especially in respect of a reading of the principle of legality as much as possible significant and dynamic

  6. Economic and organizational sustainability of a negative-pressure portable device for the prevention of surgical-site complications

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    Foglia E

    2017-06-01

    Full Text Available Emanuela Foglia,1 Lucrezia Ferrario,1 Elisabetta Garagiola,1 Giuseppe Signoriello,2 Gianluca Pellino,3 Davide Croce,1,4 Silvestro Canonico3 1Centre for Health Economics, Social and Health Care Management - LIUC University, Castellanza, Italy; 2Department of Mental Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 3School of Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 4School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South \tAfrica Purpose: Surgical-site complications (SSCs affect patients’ clinical pathway, prolonging their hospitalization and incrementing their management costs. The present study aimed to assess the economic and organizational implications of a portable device for negative-pressure wound therapy (NPWT implementation, compared with the administration of pharmacological therapies alone for preventing surgical complications in patients undergoing general, cardiac, obstetrical–gynecological, or orthopedic surgical procedures.Patients and methods: A total of 8,566 hospital procedures, related to the year 2015 from one hospital, were evaluated considering infection risk index, occurrence rates of SSCs, drug therapies, and surgical, diagnostic, and specialist procedures and hematological exams. Activity-based costing and budget impact analyses were implemented for the economic assessment.Results: Patients developing an SSC absorbed i 64.27% more economic resources considering the length of stay (€ 8,269±2,096 versus € 5,034±2,901, p<0.05 and ii 42.43% more economic resources related to hematological and diagnostic procedures (€ 639±117 versus € 449±72, p<0.05. If the innovative device had been used over the 12-month time period, it would have decreased the risk of developing SSCs; the hospital would have realized an average reduction in health care expenditure equal to −0.69% (−€ 483

  7. The influence of parenting on maladaptive cognitive schema: a cross-sectional research on a group of adults

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    Pellerone M

    2017-02-01

    Full Text Available Monica Pellerone,1 Calogero Iacolino,1 Giuseppe Mannino,2 Ivan Formica,3 Simona Maria Zabbara1 1Faculty of Human and Social Sciences, “Kore” University of Enna, Enna, Sicily, Italy; 2Department of Jurisprudence, “LUMSA” University, Rome, Italy; 3Department of Cognitive, Psychological, Pedagogical Sciences and Cultural Studies, University of Study of Messina, Messina, Sicily, Italy Background: The literature emphasizes the role of early interpersonal experiences in the development of cognitive vulnerability; in particular, interruptions in early family relationships, parental unavailability and dysfunctional parenting are potential evolutionary precursors to negative cognitive style and emotional disorders.Materials and methods: This study measured the relationship of retrospective ratings on parental bonding with cognitive patterns in a group of Italian adults. The objectives of this study were as follows: to analyze the influence of age and education level on cognitive domains; to verify whether being parents and living at home with parents affect both parenting style and cognitive domains; to investigate how the type of the maternal and paternal parenting independently affects cognitive styles; to measure the predictive variables for the use of cognitive dysfunctional patterns and to investigate age as a moderating variable of the relation between parenting styles and cognitive domains in a group of adult men and women. The research involved 209 adults (118 males and 91 females living in Sicily (Italy aged between 20 and 60 years (M = 37.52; SD = 11.42. The research lasted for 1 year. The instruments used were the Parental Bonding Instrument to measure the perception of parenting during childhood and the Young Schema Questionnaire-3 to investigate cognitive patterns.Results: Data show that being a younger adult male with mother’s parenting style characterized by a lower level of nurturance is predictive of the disconnection and

  8. Coronary artery disease in Africa and the Middle East

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    Kurdi MI

    2012-02-01

    Full Text Available Wael Almahmeed1, Mohamad Samir Arnaout2, Rafik Chettaoui3, Mohsen Ibrahim4, Mohamed Ibrahim Kurdi5, Mohamed Awad Taher6, Giuseppe Mancia71Heart and Vascular Institute, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates; 2American University of Beirut Medical Center, Beirut, Lebanon; 3General and Cardiovascular Clinic of Tunis, Tunisia; 4Cairo University, Cairo, Egypt; 5King Khalid University Hospital and The Kingdom Hospital, Saudi Arabia; 6Ain Shams University School of Medicine, Cairo, Egypt; 7University of Milan, Bicocca, Milan, ItalyAbstract: Countries in Africa and the Middle East bear a heavy burden from cardiovascular disease. The prevalence of coronary heart disease is promoted in turn by a high prevalence of cardiovascular risk factors, particularly smoking, hypertension, dyslipidemia, diabetes, and sedentary lifestyles. Patients in Africa and the Middle East present with myocardial infarction at a younger age, on average, compared with patients elsewhere. The projected future burden of mortality from coronary heart disease in Africa and the Middle East is set to outstrip that observed in other geographical regions. Recent detailed nationally representative epidemiological data are lacking for many countries, and high proportions of transient expatriate workers in countries such as Saudi Arabia and the United Arab Emirates complicate the construction of such datasets. However, the development of national registries in some countries is beginning to reveal the nature of coronary heart disease. Improving lifestyles (reducing calorie intake and increasing physical activity in patients in the region will be essential, although cultural and environmental barriers will render this difficult. Appropriate prescribing of pharmacologic treatments is essential in the prevention and management of cardiovascular disease. In particular, recent controversies relating to the therapeutic profile of beta-blockers may have reduced their use. The

  9. Pavia symposium on embryos and stem cells

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    M Boiani

    2009-08-01

    (Denmark, Jose Cibelli (USA, Ruggero De Maria (Italy, Stephen Minger (UK, Maurilio Sampaolesi (Belgium, Hans Schöler (Germany, Giuseppe Testa (Italy, Catherine Verfaillie (Belgium and Magdalena Zernicka-Goetz (UK. Here, we present the organizers’ perspective on the meeting. It goes without saying that we may not have rendered the contents the same way as the speakers did, but we do hope that the overall meaning was preserved. The speakers have been invited to contribute to a comprehensive account of the meeting, and we hope this report makes a good start.

  10. Surgery in asymptomatic patients with colorectal cancer and unresectable liver metastases: the authors' experience

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    Boselli C

    2013-03-01

    Full Text Available Carlo Boselli,1 Claudio Renzi,2 Alessandro Gemini,1 Elisa Castellani,1 Stefano Trastulli,2 Jacopo Desiderio,2 Alessia Corsi,2 Francesco Barberini,1 Roberto Cirocchi,2 Alberto Santoro,3 Amilcare Parisi,4 Adriano Redler,3 Giuseppe Noya1 1Department of General and Oncologic Surgery, University of Perugia, Perugia, 2Department of General Surgery, University of Perugia, St Maria Hospital, Terni, 3Department of Surgical Sciences, Sapienza University of Rome, Rome, 4Department of Digestive Surgery, St Maria Hospital, Terni, Italy Purpose: In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases. Patients and methods: Patients receiving elective surgery (n = 17 were compared to patients receiving chemotherapy only (n = 31. Data concerning patients' demographics, location of primary tumor, comorbidities, performance status, Child–Pugh score, extension of liver metastases, size of primary, and other secondary locations were collected. Results: Thirty-day mortality after chemotherapy was lower than that after surgical resection (19.3% versus 29.4%; not significant. In patients with >75% hepatic involvement, mortality at 1 month was higher after receiving surgical treatment than after chemotherapy alone (50% versus 25%. In patients with <75% hepatic involvement, 30-day mortality was similar in both groups (not significant. Thirty-day mortality in patients with Stage T3 was lower in those receiving chemotherapy (16.7% versus 30%; not significant. Overall survival was similar in both groups. The risk of all-cause death after elective surgery (2.1 was significantly higher than in patients receiving chemotherapy only (P = 0.035. Conclusion: This study demonstrated that in palliative treatment of asymptomatic unresectable Stage

  11. The Journal “Geopolitica” and Formation of the Italian Geopolitical School

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    Maximilian Al’bertovich Shepelev

    2017-12-01

    Full Text Available The article reveals the origins, methodological features and the process of institutionalization of Italian geopolitical school, place and role of the journal “Geopolitica” in this process. The article analyzes the characteristics of Italian geopolitical perception of the world and its geostrategic priorities, formulated by the representatives of the Italian geopolitical schools in the period of its formation in 20-40-ies of the XX century (the Mediterranean - Mare nostrum, Euroafrica. The source of the formation of the Italian geopolitical school was the intellectual influence of irredentism un the age of the Risorgimento. The process of its formation was correlated with the formation of the modern national school of geographical science, in which was dominated the perception of geography as “utilitarian science” and developed the direction of “dynamic political geography”. Its specifical features was the “antideterminism” and “geographic humanism”, the recognition that the environment does not have absolute power over society, but political will is a determining factor in anthropogeographical area. The institutionalization of Italian political school promoted the creation of several research centres in the 20-30-ies and publishing from January 1939 to December 1942 magazine “Geopolitica”. The draft edition of this magazine received support from the minister of national education Giuseppe Bottai, it was headed by Professor Giorgio Roletto and his disciple, Ernesto Massi. Italian geopolitics maintained close ties with their German colleagues, but they were theoretically justified differences between “Latin” and “German” geopolitical worldviews. Unlike the German geopolitics, the concept of “living space” was used primarily in the economic sense, but it was not used in a racial-demographic sense. Italian geopolitics acted against the world order enshrined in the Treaty of Versailles, because it was protected

  12. Efficacy of intravitreal dexamethasone implant for prostaglandin-induced refractory pseudophakic cystoid macular edema: case report and review of the literature

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    Sacchi M

    2014-07-01

    Full Text Available Matteo Sacchi, Edoardo Villani, Francesca Gilardoni, Paolo Nucci University Eye Clinic, San Giuseppe Hospital, University of Milan, Milan, Italy Background: Macular edema is a known complication even after uneventful cataract surgery. The chronic use of prostaglandin analogs is a risk factor for the development of pseudophakic cystoid macular edema (CME. Nonsteroidal anti-inflammatory drugs (NSAIDs are considered first-line therapy but refractory postsurgical CME represents a therapeutic challenge, as there is not an evidence-based treatment.Objective: To report the use of a single implant of intravitreal dexamethasone for tafluprost-associated pseudophakic CME refractory to NSAIDs and to sub-Tenon’s corticosteroid injections.Case report: A 64-year-old female with ocular hypertension treated with tafluprost experienced decreased vision (visual acuity 20/60 and metamorphopsia 2 months after uneventful cataract extraction. Spectral domain optical coherence tomography (SD-OCT revealed CME. After 1 month of topical and oral NSAIDs, CME was still evident on SD-OCT (visual acuity 20/50. Two sub-Tenon’s betamethasone injections were performed at a 2-week interval. As CME was still present, 2 months after the diagnosis of CME (visual acuity 20/40, the patient underwent a single dexamethasone intravitreal implant. One month later, macular appearance was normal, and visual acuity increased to 20/30. This result was maintained throughout the 6 months of follow-up.Conclusion: In this report, a single implant of intravitreal dexamethasone successfully treated pseudophakic CME associated with the use of prostaglandin analogs unresponsive to NSAIDs and sub-Tenon’s betamethasone. The results of this report need to be corroborated by powered, prospective, randomized trials. The need for repeated treatments as well as the retreatment interval in patients requiring more than a single injection are issues still needing further investigations. Keywords

  13. Cognitive behavioral therapy to aid weight loss in obese patients: current perspectives

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    Castelnuovo G

    2017-06-01

    Full Text Available Gianluca Castelnuovo,1,2 Giada Pietrabissa,1,2 Gian Mauro Manzoni,1,3 Roberto Cattivelli,1,2 Alessandro Rossi,1 Margherita Novelli,1 Giorgia Varallo,1 Enrico Molinari1,2 1Psychology Research Laboratory, Istituto Auxologico Italiano IRCCS, San Giuseppe Hospital, Verbania, 2Department of Psychology, Catholic University of Milan, Milan, 3Faculty of Psychology, eCampus University, Novedrate, Italy Abstract: Obesity is a chronic condition associated with risk factors for many medical ­complications and comorbidities such as cardiovascular diseases, some types of cancer, osteoarthritis, hypertension, dyslipidemia, hypercholesterolemia, type-2 diabetes, obstructive sleep apnea syndrome, and different psychosocial issues and psychopathological disorders. Obesity is a highly complex, multifactorial disease: genetic, biological, psychological, behavioral, familial, social, cultural, and environmental factors can influence in different ways. Evidence-based strategies to improve weight loss, maintain a healthy weight, and reduce related comorbidities typically integrate different interventions: dietetic, nutritional, physical, behavioral, psychological, and if necessary, pharmacological and surgical ones. Such treatments are implemented in a multidisciplinary context with a clinical team composed of endocrinologists, nutritionists, dietitians, physiotherapists, psychiatrists, psychologists, and sometimes surgeons. Cognitive behavioral therapy (CBT is traditionally recognized as the best established treatment for binge eating disorder and the most preferred intervention for obesity, and could be considered as the first-line treatment among psychological approaches, especially in a long-term perspective; however, it does not necessarily produce a successful weight loss. Traditional CBT for weight loss and other protocols, such as enhanced CBT, enhanced focused CBT, behavioral weight loss treatment, therapeutic education, acceptance and commitment therapy

  14. Patterns of treatment and costs of intermediate and advanced hepatocellular carcinoma management in four Italian centers

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    Colombo GL

    2015-10-01

    Full Text Available Giorgio Lorenzo Colombo,1 Calogero Cammà,2 Adolfo Francesco Attili,3 Roberto Ganga,4 Giovanni Battista Gaeta,5 Giuseppina Brancaccio,5 Jean Marie Franzini,6 Marco Volpe,6 Giuseppe Turchetti7 1Department of Drug Sciences, University of Pavia, Pavia, Italy; 2Section of Gastroenterology, Di.Bi.M.I.S., University of Palermo, Palermo, Italy; 3Department of Clinical Medicine, University of Rome (La Sapienza Rome, Italy; 4Clinical Medicine Division, Ospedale Brotzu, Cagliari, Italy; 5Viral Hepatitis Unit, Second University, Naples, Italy; 6Business Integration Partners S.p.A., Milan, Italy; 7Scuola Superiore Sant’Anna, Pisa, Italy Background: Hepatocellular carcinoma (HCC is a severe health condition associated with high hospitalizations and mortality rates, which also imposes a relevant economic burden.Purpose: The aim of the present survey is to investigate treatment strategies and related costs for HCC in the intermediate and advanced stages of the disease. Patients and methods: The survey was conducted in four Italian centers through structured interviews with physicians. Information regarding the stage of disease, treatments performed, and related health care resource consumption was included in the questionnaire. Direct health care cost per patient associated with the most relevant treatments such as sorafenib, transarterial chemoembolization (TACE, and transarterial radioembolization (TARE was evaluated.Results: Between 2013 and 2014, 285 patients with HCC were treated in the four participating centers; of these, 80 were in intermediate stage HCC (Barcelona Clinic Liver Cancer Classification [BCLC] B, and 57 were in the advanced stage of the disease (BCLC C. In intermediate stage HCC, the most frequent first-line treatment was TACE (63% followed by sorafenib (15%, radiofrequency ablation (14%, and TARE (1.3%. In the advanced stage of HCC, the most frequently used first-line therapy was sorafenib (56%, followed by best supportive care (21

  15. Scaling up health knowledge at European level requires sharing integrated data: an approach for collection of database specification

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    Menditto E

    2016-06-01

    Full Text Available Enrica Menditto,1 Angela Bolufer De Gea,2 Caitriona Cahir,3,4 Alessandra Marengoni,5 Salvatore Riegler,1 Giuseppe Fico,6 Elisio Costa,7 Alessandro Monaco,8 Sergio Pecorelli,5 Luca Pani,8 Alexandra Prados-Torres9 1School of Pharmacy, CIRFF/Center of Pharmacoeconomics, University of Naples Federico II, Naples, Italy; 2Directorate-General for Health and Food Safety, European Commission, Brussels, Belgium; 3Division of Population Health Sciences, Royal College of Surgeons in Ireland, 4Department of Pharmacology and Therapeutics, St James’s Hospital, Dublin, Ireland; 5Department of Clinical and Experimental Science, University of Brescia, Brescia; 6Life Supporting Technologies, Photonics Technology and Bioengineering Department, School of Telecomunications Engineering, Polytechnic University of Madrid, Madrid, Spain; 7Faculty of Pharmacy, University of Porto, Porto, Portugal; 8Italian Medicines Agency – AIFA, Rome, Italy; 9EpiChron Research Group on Chronic Diseases, Aragón Health Sciences Institute (IACS, IIS Aragón REDISSEC ISCIII, Miguel Servet University Hospital, University of Zaragoza, Zaragoza, Spain Abstract: Computerized health care databases have been widely described as an excellent opportunity for research. The availability of “big data” has brought about a wave of innovation in projects when conducting health services research. Most of the available secondary data sources are restricted to the geographical scope of a given country and present heterogeneous structure and content. Under the umbrella of the European Innovation Partnership on Active and Healthy Ageing, collaborative work conducted by the partners of the group on “adherence to prescription and medical plans” identified the use of observational and large-population databases to monitor medication-taking behavior in the elderly. This article describes the methodology used to gather the information from available databases among the Adherence Action Group partners

  16. Evaluation of the stability of linezolid in aqueous solution and commonly used intravenous fluids

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    Taylor R

    2017-07-01

    Full Text Available Rachel Taylor, Bruce Sunderland, Giuseppe Luna, Petra Czarniak School of Pharmacy, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia Purpose: The aim was to evaluate the stability of linezolid in commonly used intravenous fluids and in aqueous solution to determine the kinetics of degradation and shelf-life values at alkaline pH values. Methods: Forced degradation studies were performed on linezolid in solution to develop a validated high-performance liquid chromatography analysis. Sodium chloride 0.9%, sodium lactate, and glucose 5% and glucose 10% solution containing 2.0 mg/mL linezolid were stored at 25.0°C (±0.1°C for 34 days. The effect of temperature on the stability of linezolid in 0.1 M sodium hydroxide solution was investigated to determine the activation energy. The degradation rates of linezolid at selected pH values at 70.0°C and the influence of ionic strength were also examined. Activation energy data were applied to determine the shelf-life values at selected pH values, and a pH rate profile was constructed over the pH range of 8.7–11.4. The stability of intravenous linezolid (Zyvox® solution was evaluated by storing at 70.0°C for 72 hours. Results: Linezolid was found to maintain >95.0% of its initial concentration after storage at 25.0°C for 34 days in sodium lactate, 0.9% in sodium chloride, and 5% and 10% in glucose solutions. Linezolid was degraded at alkaline pH values by first-order kinetics. Activation energy data showed that temperature, but not ionic strength, influenced the degradation rate significantly. An activation energy of 58.22 kJ/mol was determined for linezolid in 0.1 M sodium hydroxide solution. Linezolid was least stable at high pH values and at elevated temperatures. It was determined that linezolid has adequate stability for the preparation of intravenous fluids for clinical administration. Conclusion: Linezolid was found to have a shelf life of 34 days at 25°C when added to

  17. The use of sugammadex for bariatric surgery: analysis of recovery time from neuromuscular blockade and possible economic impact

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    De Robertis E

    2016-06-01

    Full Text Available Edoardo De Robertis,1 Geremia Zito Marinosci,1 Giovanni Marco Romano,1 Ornella Piazza,2 Michele Iannuzzi,1 Fabrizio Cirillo,1 Stefania De Simone,3 Giuseppe Servillo,1 1Department of Neurosciences, Reproductive and Odontostomatologic Sciences, University Federico II, Naples, 2Department of Medicine and Surgery, University of Salerno, Salerno, 3Institute for Research on Innovation and Services for Development, National Research Council, Naples, Italy Background: Neuromuscular block (NMB monitoring and use of reversal agents accelerate the recovery time and improve the workflow in the operating room. We aimed to compare recovery times after sugammadex or neostigmine administration, and estimate the time spent in operating theater and the possible economic impact of a faster recovery, in morbidly obese patients undergoing bariatric surgery. Methods: We conducted a retrospective study that analyzed data from records of morbidly obese patients (body mass index >40 kg/m2 undergoing elective laparoscopic bariatric surgery in which sugammadex or neostigmine were used to reverse NMB. Patients were divided in two groups: group 1 (sugammadex group [SUG] received rocuronium and sugammadex for reversal and group 2 (neostigmine group [NEO] received either rocuronium or cisatracurium and neostigmine. Data are presented as mean (standard deviation. Results: Compared with NEO, SUG group showed shorter times to achieve train-of-four ratio of 0.9 (P<0.05 and an Aldrete score of 10 (P<0.05, a higher cost (€146.7 vs €3.6 [P<0.05], plus a remarkable less duration of operating theater occupancy (P<0.05. Sugammadex cost accounted for 2.58% of the total cost per surgery, while neostigmine cost accounted for 0.06%. Total time saved in SUG group was 19.4 hours, which could be used to perform 12 extra laparoscopic sleeve gastrectomies. Conclusion: Reversal from NMB was significantly faster with sugammadex than with neostigmine. Although sugammadex was substantially

  18. The emergence of "scientific" psychology in Italy between positivist philosophy and psychiatric tradition.

    Science.gov (United States)

    Cimino, Guido

    2006-01-01

    In Italy, the emergence of a psychology that can be considered "scientific" is not an event that can be easily ascribed to a precise date. It involves instead a general shift of ideas, gradual initiatives of a cultural and institutional nature, and new approaches to research, all of which together, in the course of the last thirty years of the nineteenth century and the first decade of the twentieth century, form a "critical mass" that identifies psychology as an autonomous science, distinct from both philosophy and from neurophysiology and psychiatry. This event is embedded in--and favoured by--a matrix of positivist and evolutionist thought, which gives rise to the necessity and to the problem of confronting the study of mental phenomena with a "positive method," and therefore of detaching such phenomena from their philosophical grounds in order to lead them within the sphere of science. Among the numerous elaborations upon this theme, the works that occupy a particularly prominent place are those of the positivist philosopher Roberto Ardigò and of the anthropologist Giuseppe Sergi, who in view of their theoretical proposal of a "new" science of the mind are considered the precursors or pioneers of "scientific" psychology in Italy. The same positivist philosophical-cultural background simultaneously induced some psychiatrists to open their mental health centres to the first researches of a strictly psychological nature to be conducted with the experimental method. In this regard, a particularly important figure is that of Gabriele Buccola, who was especially dedicated to these investigations and was the first Italian scholar to approach in a systematic way experimental research on mental phenomena. Little by little, in the years bridging the two centuries, a second generation of scholars, for the most part psychiatrists by formation (among whom Ferrari, De Sanctis, Kiesow, and De Sarlo), began to hold lessons of experimental psychology in the universities, to

  19. Tapentadol prolonged release for patients with multiple myeloma suffering from moderate-to-severe cancer pain due to bone disease

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    Coluzzi F

    2015-05-01

    Full Text Available Flaminia Coluzzi,1,2 Robert B Raffa,3 Joseph Pergolizzi,4 Alessandra Rocco,1 Pamela Locarini,1 Natalia Cenfra,5 Giuseppe Cimino,5 Consalvo Mattia1,2 1Department of Medical and Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Unit of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Polo Pontino, Sapienza University of Rome, Latina, Italy; 2SIAARTI Study Group on Acute and Chronic Pain, Rome, Italy; 3Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA; 4Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 5Department of Cellular Biotechnology and Hematology, Sapienza University of Rome, Rome, Italy Context: Myeloma bone disease (MBD is a devastating complication of multiple myeloma that leads to severe pain. Objectives: The aim of this study was to evaluate the efficacy and tolerability of tapentadol prolonged release (PR in the management of patients with MBD suffering from moderate-to-severe cancer pain. Methods: A 12-week prospective study was carried out in 25 opioid-naïve MBD patients. Patients initially received twice-daily doses of tapentadol PR 50 mg. Doses were then managed to maintain adequate relief or dose-limiting toxicity. The following parameters were recorded at weekly intervals for 4 weeks, and then at weeks 8 and 12: pain, opioid-related adverse effects, use of other analgesics, DN4 (Douleur Neuropathique 4 score. Quality of life (SF-36 [36-item short-form health survey] was measured at baseline and at final evaluation. Results: Of 25 patients, 22 completed the study. Pain intensity significantly decreased from baseline to all the week intervals (P<0.01. Quality of life significantly improved with respect to all SF-36 subscale parameters (P<0.01, and so did both the physical and mental status (P<0.01. Tapentadol PR significantly reduced DN4 mean value (P<0.01 and the number of patients with neuropathic component

  20. Cognitive fluctuations in connection to dysgraphia: a comparison of Alzheimer’s disease with dementia Lewy bodies

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    Onofri E

    2015-03-01

    Full Text Available Emanuela Onofri, Marco Mercuri, Giuseppe Donato, Serafino Ricci Department of Anatomy, Histology, Legal Medicine and Orthopaedics, Sapienza University of Rome, Rome, Italy Background: The purpose of the present study was to examine the relationship between cognitive impairment and the performance of handwritten scripts presented as“letter-writing” to a close relative by patients with dementia Lewy bodies (DLB, as fluctuations of the symptoms phase, and in a matched group of patients with Alzheimer’s disease (AD. The degree of writing disability and personal, spatial, and temporal orientation was compared in these two groups. Design and methods: Fourteen simple questions, designed in a form that could be utilized by any general practitioner in order to document the level of cognitive functioning of each patient, were presented to 30 AD patients and 26 DLB patients. The initial cognition test was designated PQ1. The patients were examined on tests of letter-writing ability. Directly after the letter-writing, the list of 14 questions presented in PQ1 was presented again in a repeated procedure that was designated PQ2. The difference between these two measures (PQ1 – PQ2 was designated DΔ. This test of letter-writing ability and cognitive performance was administered over 19 days.Results: Several markedly strong relationships between dysgraphia and several measures of cognitive performance in AD patients and DLB patients were observed, but the deterioration of performance from PQ1 to PQ2 over all test days were markedly significant in AD patients and not significant in DLB patients. It is possible that in graphic expression even by patients diagnosed with moderate to relatively severe AD and DLB there remains some residual capacity for understanding and intention that may be expressed. Furthermore, the deterioration in performance and the differences noted in AD and DLB patients may be due to the different speed at which the process of the

  1. Seriousness, preventability, and burden impact of reported adverse drug reactions in Lombardy emergency departments: a retrospective 2-year characterization

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    Perrone V

    2014-12-01

    Full Text Available Valentina Perrone,1,* Valentino Conti,2,* Mauro Venegoni,2 Stefania Scotto,2 Luca Degli Esposti,3 Diego Sangiorgi,3 Lucia Prestini,4 Sonia Radice,1 Emilio Clementi,5,6 Giuseppe Vighi,2,4 1Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital Luigi Sacco, Università di Milano, Milan, Italy; 2Regional Centre for Pharmacovigilance, Lombardy, Milan, Italy; 3CliCon Srl, Health, Economics and Outcomes Research, Ravenna, Italy; 4Unit of Clinical Pharmacology and Pharmacovigilance, Niguarda Ca’Granda Hospital, Milan, Italy; 5Unit of Clinical Pharmacology, CNR Institute of Neuroscience, Department of Biomedical and Clinical Sciences, University Hospital Luigi Sacco, Università di Milano, Milan, Italy; 6Scientific Institute, IRCCS Eugenio Medea, Lecco, Italy *These authors contributed equally to the work Objective: The purpose of this study was to determine the prevalence of adverse drug reactions (ADRs reported in emergency departments (EDs and carry out a thorough characterization of these to assess preventability, seriousness that required hospitalization, subsequent 30-day mortality, and economic burden. Methods: This was a retrospective cohort study of data from an active pharmacovigilance project at 32 EDs in the Lombardy region collected between January 1, 2010 and December 31, 2011. Demographic, clinical, and pharmacological data on patients admitted to EDs were collected by trained and qualified monitors, and deterministic record linkage was performed to estimate hospitalizations. Pharmacoeconomic analyses were based on Diagnosis-Related Group reimbursement. Results: 8,862 ADRs collected with an overall prevalence rate of 3.5 per 1,000 visits. Of all ADRs, 42% were probably/definitely preventable and 46.4% were serious, 15% required hospitalization, and 1.5% resulted in death. The System Organ Classes most frequently associated with ADRs were: skin and subcutaneous tissue, gastrointestinal

  2. Echographic detectability of optoacoustic signals from low-concentration PEG-coated gold nanorods

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    Conversano F

    2012-08-01

    Full Text Available Francesco Conversano,1 Giulia Soloperto,1 Antonio Greco,1 Andrea Ragusa,1,2 Ernesto Casciaro,1 Fernanda Chiriacò,1 Christian Demitri,3 Giuseppe Gigli,2–5 Alfonso Maffezzoli,3 Sergio Casciaro11National Research Council, Institute of Clinical Physiology, Lecce, Italy; 2National Nanotechnology Laboratory of CNR-NANO, Lecce, Italy; 3University of Salento, Department of Engineering for Innovation, Lecce, Italy; 4Italian Institute of Technology – Center for Biomolecular Nanotechnology (CBN-IIT, Arnesano, Italy; 5University of Salento, Department of Mathematics and Physics ‘Ennio De Giorgi’, Lecce, ItalyPurpose: To evaluate the diagnostic performance of gold nanorod (GNR-enhanced optoacoustic imaging employing a conventional echographic device and to determine the most effective operative configuration in order to assure optoacoustic effectiveness, nanoparticle stability, and imaging procedure safety.Methods: The most suitable laser parameters were experimentally determined in order to assure nanoparticle stability during the optoacoustic imaging procedures. The selected configuration was then applied to a novel tissue-mimicking phantom, in which GNR solutions covering a wide range of low concentrations (25–200 pM and different sample volumes (50–200 µL were exposed to pulsed laser irradiation. GNR-emitted optoacoustic signals were acquired either by a couple of single-element ultrasound probes or by an echographic transducer. Off-line analysis included: (a quantitative evaluation of the relationships between GNR concentration, sample volume, phantom geometry, and amplitude of optoacoustic signals propagating along different directions; (b echographic detection of “optoacoustic spots,” analyzing their intensity, spatial distribution, and clinical exploitability. MTT measurements performed on two different cell lines were also used to quantify biocompatibility of the synthesized GNRs in the adopted doses.Results: Laser irradiation at

  3. Evidence for preferences of Italian patients for physician attire

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    Sotgiu G

    2012-04-01

    Full Text Available Giovanni Sotgiu1, Paolo Nieddu2, Laura Mameli2, Enrico Sorrentino2, Pietro Pirina3, Alberto Porcu4, Stefano Madeddu1, Manuela Idini1, Maddalena Di Martino1, Giuseppe Delitala2, Ida Mura1, Maria Pina Dore21Epidemiology and Medical Statistics Unit, Department of Biomedical Sciences, 2Clinica Medica, 3Pneumologia, 4Chirurgia dell’Obesità, University of Sassari, Sassari, ItalyBackground: The relationship between patient and physician is a complex interaction that includes multiple factors. The objective of this study was to explore Italian patients’ preferences regarding physician appearance.Methods: A questionnaire was developed to survey patients in different medical and surgical settings; each subject was asked to choose one picture of either a male or female physician from a selection of different attires (professional, casual, surgical scrubs, trendy, and careless. Patients were also surveyed about issues such as the presence of a name tag, hair length, trousers on women, amount of makeup, presence of tattoos, and body piercing. Statistical analysis was performed using a Chi-square test.Results: A total of 765 questionnaires (534 completed from patients waiting for an internal medicine visit and 231 for other subspecialties were completed. The majority (45% of patients preferred the gastroenterologist to wear a surgical scrub with a white coat. For the other specialists, patients accepted either scrubs or formal dress under a white coat (P ≤ 0.05, with a name tag. Trendy attire was preferred by nine patients (1.1%. The entire sample judged it inappropriate for clinicians to have long hair, visible tattoos, body piercing, and, for women, to wear trousers and use excessive makeup.Conclusion: This is the first study conducted in Italy regarding physician attire. As in other Western countries, Italian patients favor physicians in professional attire with a white coat. Wearing professional dress is part of “etiquette based medicine” and

  4. An historic discovery around the corner from school: Ceres, a solar system object with an uncertain identity.

    Science.gov (United States)

    Stira, Salvatore

    2016-04-01

    Ceres is the largest object in the asteroid belt between Mars and Jupiter, and it was discovered on January 1, 1801, by the Italian astronomer Giuseppe Piazzi. The study of Ceres is especially relevant to my students because this celestial body was discovered in Palermo, in the astronomic observatory located in the UNESCO world heritage site "Palazzo dei Normanni", around 500 meters away from the institute where I teach, and because Ceres was considered the patron goddess of Sicily. Moreover, it received scientists and media attention recently because it was explored by the NASA Dawn spacecraft in 2015. The categorization of Ceres has changed more than once and has been the subject of some disagreement. It was originally considered a planet, but was reclassified as an asteroid in the 1850s when many other objects in similar orbits were discovered. Its status changed again in 2006 when it was promoted to dwarf planet, a classification it shares with Pluto and other Kuiper belt objects. The study of this celestial body has a notable educational value, since the uncertain identity of Ceres constitutes an occasion to reflect on the criterions of classification of the natural objects. The history of its discovery allows the students to understand as the scientific method doesn't always consist in the verification of hypothesis through experiments but it sometimes asks for the forecast of facts through mathematical calculations, repeated and methodic observations, the collaboration between scientists of different sectors and nationality. Furthermore, it is a particularly suitable topic for interdisciplinary connections, as regards both scientific and humanistic matters. In order to promote the scientific competences of my first class students, I have developed a learning unit on Ceres, thanks to good cooperation with the Palermo Observatory scientists, particularly active in the astronomic dissemination towards the schools and the citizens. The most meaningful activities

  5. Rasagiline for sleep disorders in patients with Parkinson’s disease: a prospective observational study

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    Schettino C

    2016-09-01

    Full Text Available Carla Schettino,1,2,* Clemente Dato,1,2,* Guglielmo Capaldo,1,2 Simone Sampaolo,1,2 Giuseppe Di Iorio,1,2 Mariarosa AB Melone1,2 1Department of Medical, Surgical, Neurological, Metabolic Sciences, and Aging, 2Division of Neurology and InterUniversity Center for Research in Neurosciences, Second University of Naples, Naples, Italy *These authors contributed equally to this work Introduction: Rasagiline is a selective, irreversible monoamine oxidase B inhibitor that ameliorates the symptoms of Parkinson’s disease (PD by inhibiting striatal dopamine metabolism. There is also evidence that monoamine oxidase B inhibitors increase melatonin levels in the pineal gland and may have a beneficial effect on sleep disorders, which are a common feature in patients with PD.Methods: This single-center, prospective, observational, 12-week study compared the effect of combination therapy with levodopa 200–300 mg/d + rasagiline 1 mg/d (n=19 with levodopa 200–300 mg/d alone (n=19 in the treatment of sleep disorders in patients with idiopathic PD.Results: After 12 weeks’ treatment, mean sleep latency was significantly (P<0.001 lower and the improvement in sleep latency from baseline was significantly (P=0.001 greater in patients receiving levodopa + rasagiline than in patients receiving levodopa alone. Similarly, at the end of the study, the mean total sleep time was significantly (P=0.002 longer and the improvement from baseline in mean total sleep time was significantly (P=0.026 greater in patients receiving levodopa + rasagiline than levodopa alone. There were no significant differences between treatment groups for the mean number of awakenings reported at week 12 nor the change from baseline to week 12 in mean number of awakenings.Conclusion: Adding rasagiline to levodopa improved sleep outcomes and may be an appropriate option for patients with PD experiencing sleep disorders. Keywords: Parkinson’s disease, rasagiline, sleep disorders, Parkinson

  6. The one repetition maximum test and the sit-to-stand test in the assessment of a specific pulmonary rehabilitation program on peripheral muscle strength in COPD patients

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    Zanini A

    2015-11-01

    Full Text Available Andrea Zanini,1,2 Marina Aiello,3 Francesca Cherubino,1 Elisabetta Zampogna,1 Andrea Azzola,4 Alfredo Chetta,3 Antonio Spanevello1,5 1Division of Pneumology, IRCCS Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation, Tradate, Italy; 2Division of Internal and Respiratory Medicine, Malcantonese Hospital, Giuseppe Rossi Foundation, Castelrotto, Switzerland; 3Respiratory Disease and Lung Function Unit, Department of Clinical and Experimental Medicine, University of Parma, Padiglione Rasori, Parma, Italy; 4Division of Pneumology, Department of Internal Medicine, Ospedale Civico, Lugano, Switzerland; 5Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy Background: Individuals with COPD may present reduced peripheral muscle strength, leading to impaired mobility. Comprehensive pulmonary rehabilitation (PR should include strength training, in particular to lower limbs. Furthermore, simple tools for the assessment of peripheral muscle performance are required.Objectives: To assess the peripheral muscle performance of COPD patients by the sit-to-stand test (STST, as compared to the one-repetition maximum (1-RM, considered as the gold standard for assessing muscle strength in non-laboratory situations, and to evaluate the responsiveness of STST to a PR program.Methods: Sixty moderate-to-severe COPD inpatients were randomly included into either the specific strength training group or into the usual PR program group. Patients were assessed on a 30-second STST and 1-minute STST, 1-RM, and 6-minute walking test (6MWT, before and after PR. Bland–Altman plots were used to evaluate the agreement between 1-RM and STST. Results: The two groups were not different at baseline. In all patients, 1-RM was significantly related to the 30-second STST (r=0.48, P<0.001 and to 1-minute STST (r=0.36, P=0.005. The 30-second STST was better tolerated in terms of the perceived fatigue (P=0.002 and less time consuming (P<0

  7. Quality of life in overweight (obese and normal-weight women with polycystic ovary syndrome

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    Panico A

    2017-03-01

    Full Text Available Annalisa Panico,1 Giovanni Messina,2,3 Gelsy Arianna Lupoli,1 Roberta Lupoli,1 Marianna Cacciapuoti,1 Fiorenzo Moscatelli,2 Teresa Esposito,3 Ines Villano,3 Anna Valenzano,2 Vincenzo Monda,3 Antonietta Messina,3 Francesco Precenzano,4 Giuseppe Cibelli,2 Marcellino Monda,3 Giovanni Lupoli1 1Department of Clinical Medicine and Surgery, University of Napoli Federico II, Naples, Italy; 2Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; 3Department of Experimental Medicine, Second University of Naples, Naples, Italy; 4Department of Mental and Physical Health, and Preventive Medicine, Child and Adolescent Neuropsychiatry Unit, Second University of Naples, Naples, Italy Objective: Polycystic ovary syndrome (PCOS is characterized by phenotypic heterogeneity and has a wide variety of consequences. Approximately half of women with PCOS are overweight or obese, and their obesity may be a contributing factor to PCOS pathogenesis through different mechanisms. The aim of this study was to evaluate if PCOS alone affects the patients’ quality of life and to what extent obesity contributes to worsen this disease. Design: To evaluate the impact of PCOS on health-related quality-of-life (HRQoL, 100 Mediterranean women with PCOS (group A, 50 with a body mass index (BMI >25 kg/m2 (group A1 and 50 with BMI <25 kg/m2 (group A2, were recruited. They were evaluated with a specific combination of standardized psychometric questionnaires: the Symptom Checklist-90 Revised, the 36-Item Short-Form Health Survey, and the Polycystic Ovary Syndrome Questionnaire. The patients were compared with a normal-weight healthy control group of 40 subjects (group B. Another control group of 40 obese healthy women (group C was used to make a comparison with PCOS obese patients (A1. Results: Our results showed a considerable worsening of HRQoL in PCOS patients (A compared with controls (B. In addition, patients with PCOS and BMI >25 (A1 showed a

  8. Il mestiere di tradurre 2: Pepa Linares

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    Pepa Linares

    2014-01-01

    Full Text Available Con una trayectoria iniciada hace ya más de dos décadas, basta echar una rápida hojeada a los últimos títulos traducidos por Pepa Linares para dejar constancia de la variedad de temas y autores que caracterizan su intenso trabajo como traductora. Si en los últimos años ha volcado del inglés escritores tan dispares como la iraní Bahiyyih Nakhjavani (La mujer que leía demasiado, Alianza, 2012, autores noveles como Travis Holland (El archivero de la Lubianka, Alianza, 2008 o clásicos como Edith Wharton (Xingú, Contraseña, 2012, Muriel Spark (El asiento del conductor, Contraseña, 2011 y Bernard Malamud (Las vidas de Dubin, Sajalín, 2011, la extensísima nómina de escritores italianos pasa por narradores de la talla de Giuseppe Bonaviri (El enorme tiempo: apuntes para un diario de un médico siciliano, Sajalín, 2011 y Luigi Bartolini (Ladrones de bicicletas, Sajalín, 2009 o ensayistas y politólogos como Carlo Mongardini (Miedo y sociedad, 2007, Laura Zanfrini (La convivencia interétnica, 2007, Gianpietro Mazzoleni (La comunicación política, 2010 o Gianfranco Poggi (Weber, Alianza, 2006, estos últimos publicados en Alianza, por mencionar tan solo unos pocos autores. Tres de sus últimos trabajos aparecidos a lo largo de 2013, Mi Carso, de Scipio Slataper (Ardicia, Un día de fuego: cuentos completos y la novela El partisano Johnny, de Beppe Fenoglio (ambos en Sajalín pueden sin ninguna duda contarse entre las novedades editoriales más interesantes de este año. Coincidiendo con la aparición de estos relevantes títulos y abusando de su amabilidad, nos permitimos plantearle algunas preguntas sobre su interesante labor. Entrevista de Juan Pérez Andrés.

  9. The role of duloxetine in the treatment of anxiety disorders

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    Domenico De Berardis

    2008-07-01

    Full Text Available Domenico De Berardis1,2,3, Nicola Serroni2, Alessandro Carano1,4, Marco Scali1,4, Alessandro Valchera5, Daniela Campanella1,2, Alessandro D’Albenzio1, Berardo Di Giuseppe2, Francesco Saverio Moschetta2, Rosa Maria Salerno1, Filippo Maria Ferro11Department of Oncology and Neurosciences, Institute of Psychiatry, “G. D’Annunzio” University of Chieti, Italy; 2National Health Service, Department of Mental Health, SPDC Teramo, Italy; 3ITAB, Institute for Advanced Biomedical Technologies, “G. D’Annunzio” University Foundation, Chieti, Italy; 4National Health Service, Department of Mental Health, ASUR Marche 8, Civitanova Marche, Italy; 5Division of Psychiatry, “S. Giuseppe” Clinic, Ascoli Piceno, ItalyAbstract: Anxiety disorders (ADs are the most common type of psychiatric disorders, with a mean incidence of 18.1% and a lifetime prevalence of 28.8%. Pharmacologic options studied for treating ADs may include benzodiazepines, tricyclic antidepressants (TCA, selective serotonin reuptake inhibitors (SSRIs, noradrenergic and specific serotonergic drug (NaSSA and dual-reuptake inhibitors of serotonin and norepinephrine (SNRIs. In this context, the development of SNRIs (venlafaxine and duloxetine has been particularly useful. As a dual-acting intervention that targets two neurotransmitter systems, these medications would appePar promising for the treatment of ADs. The purpose of this review was to elucidate current facts and views about the role of duloxetine in the treatment of ADs. In February 2007, duloxetine was approved by FDA for the treatment of generalized anxiety disorder (GAD. The results of trials evaluating the use duloxetine in the treatment of GAD are supportive on its efficacy even if further studies on long-term use are needed. Apart from some interesting case reports, no large studies are, to date, present in literature about duloxetine and other ADs such as panic disorder, social anxiety disorder, obsessive

  10. JC virus antibody index in natalizumab-treated patients: correlations with John Cunningham virus DNA and C-reactive protein level

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    Lanzillo R

    2014-10-01

    Full Text Available Roberta Lanzillo,1 Raffaele Liuzzi,2 Luca Vallefuoco,3 Marcello Moccia,1 Luca Amato,1 Giovanni Vacca,1 Veria Vacchiano,1 Giuseppe Portella,3 Vincenzo Brescia Morra1 1Neurological Sciences Department, Federico II University, 2Institute of Biostructure and Bioimaging, National Research Council, 3Clinical Pathology Department, Federico II University, Naples, ItalyAbstract: Natalizumab-treated patients have a higher risk of developing progressive multifocal leukoencephalopathy. Exposure to John Cunningham virus (JCV is a prerequisite for PML (progressive multifocal leukoencephalopathy. To assess JCV exposure in multiple sclerosis patients, we performed a serological examination, obtained the antibody index, performed real-time polymerase chain reaction (PCR to detect JCV DNA in plasma and urine, and investigated the role of ultrasensitive C-reactive protein (usCRP as a possible biological marker of JCV reactivation. We retrospectively analyzed consecutive natalizumab-treated multiple sclerosis patients who underwent a JCV antibody test through a two-step enzyme-linked immunosorbent assay (STRATIFY test to the measure of serum usCRP levels, and to perform blood and urine JCV PCR. The studied cohort included 97 relapsing–remitting patients (60 women. Fifty-two patients (53.6% tested positive for anti-JCV antibodies. PCR showed JCV DNA in the urine of 30 out of 83 (36.1% patients and 28 out of 44 seropositive patients (63.6%, with a 6.7% false-negative rate for the STRATIFY test. Normalized optical density values were higher in urinary JCV DNA-positive patients (P<0.0001. Interestingly, the level of usCRP was higher in urinary JCV DNA-positive patients and correlated to the number of DNA copies in urine (P=0.028. As expected, patients' age correlated with JCV seropositivity and with JC viruria (P=0.02 and P=0.001, respectively. JC viruria was significantly correlated with a high JCV antibody index and high serum usCRP levels. We suggest that PCR and

  11. Changes in spinal range of motion after a flexibility training program in elderly women

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    Battaglia G

    2014-04-01

    Full Text Available Giuseppe Battaglia,1,2 Marianna Bellafiore,1,2 Giovanni Caramazza,2 Antonio Paoli,3 Antonino Bianco,1,2 Antonio Palma1,2 1Department of Law, Society, and Sport Sciences, University of Palermo, Palermo, Italy; 2Sicilian Regional Sports School of Italian National Olympic Committee (CONI, Sicily, Italy; 3Department of Biomedical Sciences, University of Padova, Padova, Italy Background: Aging-related reduced spinal mobility can interfere with the execution of important functional skills and activities in elderly women. Although several studies have shown positive outcomes in response to spinal flexibility training programs, little is known about the management of sets and repetitions in training protocols. The purpose of this study was to investigate the effects of an 8-week specific and standardized flexibility training program on the range of spinal motion in elderly women. Methods: Participants were recruited in a senior center of Palermo and randomly assigned in two groups: trained group (TG and control group (CG, which included 19 and 18 women, respectively. TG was trained for 8 weeks at two sessions/week. In particular, every session included three phases: warm up (~10 minutes, central period (~50 minutes, and cool down (~10 minutes. CG did not perform any physical activity during the experimental period. Spinal ranges of motion (ROM were measured from neutral standing position to maximum bending position and from neutral standing position to maximum extension position before and after the experimental period, using a SpinalMouse® device (Idiag, Volkerswill, Switzerland. Results: After the training period, TG showed an increase in spinal inclination by 16.4% (P<0.05, in sacral/hip ROM by 29.2% (P<0.05, and in thoracic ROM by 22.5% (P>0.05 compared with CG from maximum extension position to maximum bending position. We did not observe any significant difference in TG's lumbar ROM compared with CG after the training period (P>0.05. Conclusion

  12. On the detection of adobe buried archaeological structures using multiscale remote sensing techniques : Piramide Naranja in Cahuachi (Peru)

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    Masini, N.; Rizzo, E.; Lasaponara, R.; Orefici, G.

    2009-04-01

    The detection of buried adobe structures is a crucial issue for the remote sensing (ground, aerial and satellite) applied to archaeology for the widespread of sun-dried earth as building material in several ancient civilizations in Central and Southern America, Middle East and North Africa. Moreover it is complex, due to the subtle contrast existing between the archaeological features and the surrounding, especially in arid setting, as in the case of the well know Nazca Ceremonial Centre of Cahuachi, located in the desert of Nazca (Southern Peru) . During the last two decades of excavations adobe monuments dating back from the 6th century B.C. to the 4th century A.D have been highlighted by the Centro de Estudios Arqueológicos Precolombinos (CEAP), an italian-peruvian mission directed by Giuseppe Orefici. Actually, the archaeologists are excavating and restoring the core of the Ceremonial centre where is located a great pyramid (kown as Gran Piramide). Beginning from 2007 the two institutes of CNR, IMAA and IBAM, have been involved by CEAP, in order to provide a scientific and technological support for the archaeological research. Therefore, a multi-scale approach based on the integration of aerial and satellite remote sensing with geophysical techniques was employed in order to provide data useful for archaeological excavations. The abstract refers to the last investigations performed on a mound, known as "Piramide Naranja", during the 2008. The processing of an aerial imagery time series and two QuickBird satellite images acquired in 2002 and 2005, allowed for identifying some features related to shallow and buried structures. Such features were verified by means of geophysical prospections, performed by using the magnetometric method which observed changes in the magnetic field within the first few metres beneath the subsurface detecting buried walls and anomalies linked to ceramic deposits referable to possible tombs. Finally, the integration of all data

  13. The evolution of anatomical illustration and wax modelling in Italy from the 16th to early 19th centuries.

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    Riva, Alessandro; Conti, Gabriele; Solinas, Paola; Loy, Francesco

    2010-02-01

    Although the contribution to anatomical illustration by Vesalius and his followers has received much attention, less credit has been given to Veslingius and particularly Fabricius. By 1600, Fabricius had amassed more than 300 paintings that together made the Tabulae Pictae, a great atlas of anatomy that was highly admired by his contemporaries. Many of his new observations were incorporated into subsequent books, including those by Casserius, Spighelius, Harvey and Veslingius. Also of importance were the Tabulae by Eustachius (1552), which, although only published in 1714, greatly influenced anatomical wax modelling. In 1742, Pope Benedict XIV established a Museum of Anatomy in Bologna, entrusting to Ercole Lelli the creation of several anatomical preparations in wax. Felice Fontana realised that the production of a large number of models by the casting method would make cadaveric specimens superfluous for anatomical teaching and in 1771 he asked the Grand Duke to fund a wax-modelling workshop in Florence as part of the Natural History Museum, later known as La Specola. Fontana engaged Giuseppe Ferrini as his first modeller and then the 19-year-old Clemente Susini who, by his death in 1814, had superintended the production of, or personally made, more than 2000 models. In 1780, the Austrian Emperor Joseph II visited La Specola and ordered a great number of models for his Josephinum museum; these were made by Fontana with the help of Clemente Susini and supervised by the anatomist Paolo Mascagni. It is, however, in Cagliari that some of Susini's greatest waxes are to be found. These were made when he was free of Fontana's influence and were based on dissections made by Francesco Antonio Boi (University of Cagliari). Their distinctive anatomical features include the emphasis given to nerves and the absence of lymphatics in the brain, a mistake made on earlier waxes. The refined technical perfection of the anatomical details demonstrates the closeness of the

  14. Water- versus land-based exercise in elderly subjects: effects on physical performance and body composition

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    Bergamin M

    2013-08-01

    Full Text Available Marco Bergamin,1 Andrea Ermolao,1 Silvia Tolomio,1 Linda Berton,2 Giuseppe Sergi,2 Marco Zaccaria1 1Sports Medicine Division, 2Geriatrics Division, University of Padova, Padua, Italy Abstract: The aim of this study was to assess the effectiveness of a 24-week exercise protocol carried out in geothermal spring water to improve overall physical function and muscle mass in a group of healthy elderly subjects. A further aim was to compare this water-based protocol with a land-based protocol and a control group. For this purpose, 59 subjects were recruited and randomly allocated to three groups: aquatic group (AG, land group (LG, and control group (CG. AG and LG followed a 6-month, twice-weekly, multimodality exercise intervention. AG underwent the protocol in hot-spring water (36°C while LG did it in a land-based environment. After the intervention, knee-extension strength was maintained in AG and LG. The 8-foot up-and-go test showed a reduction in both exercise groups (AG −19.3%, P < 0.05; LG −12.6%, P < 0.05, with a significantly greater decrease in AG. The back-scratch test revealed an improvement only in AG (25.8%; P < 0.05, while the sit-and-reach test improved in all groups. Finally, AG reduced fat mass by 4% (P < 0.05, and dominant forearm fat decreased by 9.2% (P < 0.05. In addition, calf muscle density increased by 1.8% (P < 0.05. In summary, both water- and land-based activities were beneficial in maintaining strength and in improving lower-body flexibility. Aquatic exercise appeared a better activity to improve dynamic balance. Thermal swimming pools and the use of rating of perceived exertion as a method of exercise monitoring should be considered potentially useful tools to enhance physical performance and body composition in healthy elderly. Keywords: aging, multimodality exercise, performance, muscle mass

  15. Enhancing cognitive functioning in the elderly: multicomponent vs resistance training

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    Forte R

    2013-01-01

    Full Text Available Roberta Forte,1,2 Colin AG Boreham,1 Joao Costa Leite,3 Giuseppe De Vito,1 Lorraine Brennan,3 Eileen R Gibney,3 Caterina Pesce21Institute for Sport and Health, University College Dublin, Dublin, Ireland; 2Department of Human Movement and Sport Science, University of Rome "Foro Italico," Rome, Italy; 3Institute of Food and Health, University College Dublin, Dublin, IrelandPurpose: The primary purpose of this study was to compare the effects of two different exercise training programs on executive cognitive functions and functional mobility in older adults. A secondary purpose was to explore the potential mediators of training effects on executive function and functional mobility with particular reference to physical fitness gains.Methods: A sample of 42 healthy community dwelling adults aged 65 to 75 years participated twice weekly for 3 months in either: (1 multicomponent training, prioritizing neuromuscular coordination, balance, agility, and cognitive executive control; or (2 progressive resistance training for strength conditioning. Participants were tested at baseline (T1, following a 4-week control period (T2, and finally at postintervention (T3 for executive function (inhibition and cognitive flexibility and functional mobility (maximal walking speed with and without additional task requirements. Cardiorespiratory and muscular fitness were also assessed as potential mediators.Results: Indices of inhibition, the functions involved in the deliberate withholding of prepotent or automatic responses, and measures of functional mobility improved after the intervention, independent of training type. Mediation analysis suggested that different mechanisms underlie the effects of multicomponent and progressive resistance training. While multicomponent training seemed to directly affect inhibitory capacity, resistance training seemed to affect it indirectly through gains in muscular strength. Physical fitness and executive function variables did not

  16. Inhaled treatment of COPD: a Delphi consensus statement

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    Ninane V

    2017-03-01

    Full Text Available Vincent Ninane,1 Jean-Louis Corhay,2 Paul Germonpré,3 Wim Janssens,4 Guy F Joos,5 Giuseppe Liistro,6 Walter Vincken,7 Sandra Gurdain,8 Evelyne Vanvlasselaer,8 An Lehouck8 1Department of Respiratory Medicine, Saint-Pierre Hospital, Université Libre de Bruxelles, Brussels, 2Department of Respiratory Medicine, CHU, Liege, 3Department of Respiratory Medicine, AZ Maria Middelares, Ghent, 4Department of Respiratory Medicine, Katholieke Universiteit, Leuven, 5Department of Respiratory Medicine, Ghent University Hospital, Ghent, 6Department of Respiratory Medicine, University Hospitals Saint-Luc, Brussels, 7Department of Respiratory Medicine, University Hospital Brussels, Brussels, 8Medical Department, Novartis Pharma, Vilvoorde, Belgium Background: Global Initiative for Chronic Obstructive Lung Disease (GOLD global strategy (2015 provides guidance for the treatment of chronic obstructive pulmonary disease (COPD with different first-choice options per GOLD category without specification. Objectives: To evaluate the level of medical experts’ consensus on their preferred first-choice treatment within different COPD categories. Methods: A two-round Delphi Panel consisting of 15 questions was completed by Belgian pulmonologists (n=31 and European (n=10 COPD experts. Results: Good consensus was reached by both expert groups for long-acting bronchodilators instead of short-acting bronchodilators as first-choice treatment in GOLD A. Single bronchodilation with long-acting muscarinic antagonist (LAMA was preferred over long-acting ß2-agonist (LABA and LABA/LAMA as first-choice treatment in GOLD B and GOLD C. For GOLD D patients based on the forced expiratory volume in 1 second (FEV1<50%, a very good consensus was reached for LAMA/LABA as first-choice treatment. For GOLD D patients based on frequent or severe exacerbations, there was a good consensus for LABA/LAMA/inhaled corticosteroids (ICS as first choice in the Belgian group. According to the European

  17. Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles

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    Coulter JA

    2012-06-01

    Full Text Available Jonathan A Coulter,1 Suneil Jain,2 Karl T Butterworth,2 Laura Taggart,2 Glenn Dickson,2 Stephen J McMahon,3 Wendy Hyland,1 Mark F Muir,3 Coleman Trainor,2 Alan Hounsell,2,4 Joe M O'Sullivan,2,4 Giuseppe Schettino,2 Fred Currell,3 David G Hirst,1 Kevin M Prise21School of Pharmacy, McClay Research Centre, 2Centre for Cancer Research and Cell Biology, 3School of Mathematics and Physics, Queens University Belfast, 4Belfast Health and Social Care Trust, Belfast, IrelandBackground: This follow-up study aims to determine the physical parameters which govern the differential radiosensitization capacity of two tumor cell lines and one immortalized normal cell line to 1.9 nm gold nanoparticles. In addition to comparing the uptake potential, localization, and cytotoxicity of 1.9 nm gold nanoparticles, the current study also draws on comparisons between nanoparticle size and total nanoparticle uptake based on previously published data.Methods: We quantified gold nanoparticle uptake using atomic emission spectroscopy and imaged intracellular localization by transmission electron microscopy. Cell growth delay and clonogenic assays were used to determine cytotoxicity and radiosensitization potential, respectively. Mechanistic data were obtained by Western blot, flow cytometry, and assays for reactive oxygen species.Results: Gold nanoparticle uptake was preferentially observed in tumor cells, resulting in an increased expression of cleaved caspase proteins and an accumulation of cells in sub G1 phase. Despite this, gold nanoparticle cytotoxicity remained low, with immortalized normal cells exhibiting an LD50 concentration approximately 14 times higher than tumor cells. The surviving fraction for gold nanoparticle-treated cells at 3 Gy compared with that of untreated control cells indicated a strong dependence on cell type in respect to radiosensitization potential.Conclusion: Gold nanoparticles were most avidly endocytosed and localized within cytoplasmic

  18. Changes in corneal parameters at confocal microscopy in treated glaucoma patients

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    Ranno S

    2011-07-01

    Full Text Available Stefano Ranno1, Paolo Fogagnolo2, Luca Rossetti3, Nicola Orzalesi3, Paolo Nucci11Eye Clinic, San Giuseppe Hospital, University of Milan, Milan, Italy; 2GB Bietti Foundation for Study and Research in Ophthalmology, Rome, Italy; 3Eye Clinic, Department of Medicine, San Paolo Hospital, University of Milan, Milan, ItalyBackground: The purpose of this study was to evaluate corneal parameters in treated glaucoma patients, nontreated glaucoma patients, and normal subjects using confocal microscopy.Methods: Forty patients with primary open-angle glaucoma and 22 untreated controls underwent confocal microscopy of the cornea using the Heidelberg retinal tomograph cornea module. The glaucoma group was divided into two subgroups, ie, patients on medical treatment for at least two years before inclusion (with beta-blockers or prostaglandin analogs and nontreated glaucoma patients. The following corneal parameters were evaluated: endothelial cell density and number, reflectivity, and tortuosity of sub-basal nerves. For reflectivity and tortuosity, a dedicated grading scale ranging from 0 to 4 was used. Differences between treatments were also evaluated in the treated glaucoma group.Results: Number of fibers and reflectivity of the sub-basal plexus were significantly lower in glaucoma patients as compared with controls (2.5 ± 0.7 versus 2.9 ± 0.9, P = 0.006, and 2.3 ± 0.8 versus 2.7 ± 0.9, P = 0.04, respectively, whereas tortuosity was significantly higher (2.6 ± 1 versus 2.0 ± 0.8, P = 0.007. Endothelial cell density (measured as cells per mm2 was lower in the glaucoma group comparing treated patients with nontreated patients (2826 ± 285 versus 3124 ± 272, P = 0.0003. Comparing treated patients with nontreated patients, relevant differences were found in number (2.3 ± 0.7 versus 2.8 ± 0.8, P = 0.004, tortuosity (2.8 ± 1 versus 2.2 ± 0.8, P = 0.004, and reflectivity (2.2 ± 0.8 versus 2.6 ± 0.8, P = 0.04. No differences in corneal parameters were

  19. Retargeting the management of hypercholesterolemia – focus on evolocumab

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    Colletti A

    2016-09-01

    Full Text Available Alessandro Colletti,1 Giuseppe Derosa,2 Arrigo FG Cicero1 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, 2Department of Internal Medicine and Therapeutics, University of Pavia and Policlinico San Matteo Foundation, Pavia, Italy Abstract: Hypercholesterolemia is one of the main risk factors for atherosclerosis and cardiovascular diseases. The treatment is based on the modification of the diet and lifestyle and if necessary on a pharmacological therapy. The most widely used drugs are the inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (statins; nevertheless, many patients do not reach optimal levels of low-density lipoprotein-cholesterol (LDL-C even with maximal dosage of statins (eventually associated to ezetimibe or present side effects, which do not allow them to continue the treatment. Inhibitors of PCSK9 represent a new therapeutic approach for lowering LDL-C. Evolocumab and alirocumab are human monoclonal antibodies, which bind to extracellular PCSK9 and thus interfere with the degradation of low-density lipoprotein receptor. Evolocumab use is approved for the treatment of patients with heterozygous familial hypercholesterolemia (FH and homozygous FH as an adjunct to diet and maximally tolerated statin therapy or for subjects with clinical atherosclerotic cardiovascular disease who require additional lowering of LDL-C. Phase III clinical trials have demonstrated the effectiveness of evolocumab (140 mg/every 2 weeks or 420 mg/month, via subcutaneous injection in monotherapy and in combination with statins, in the treatment of patients intolerant to statins or with FH. In monotherapy, it reduces LDL-C by 55%, and its association with statins leads to a reduction of LDL-C by up to 63%–75%. Evolocumab has been demonstrated to be safe and well tolerated. Ongoing clinical trials are assessing the long-term effects of evolocumab on the incidence of cardiovascular risk, safety, and tolerability

  20. Long-lasting corneal endothelial graft rejection successfully reversed after dexamethasone intravitreal implant

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    Giannaccare G

    2016-07-01

    Full Text Available Giuseppe Giannaccare, Michela Fresina, Alberto Pazzaglia, Piera Versura Ophthalmology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES, Alma Mater Studiorum University of Bologna, Sant’Orsola‑Malpighi Teaching Hospital, Bologna, Italy Abstract: Graft rejection is the most significant complication corneal transplantation and the leading indication for overall corneal transplantation. Corticosteroid therapy represents the mainstay of graft rejection treatment; however, the optimal route of administration of corticosteroid remains uncertain. We report herein for the first time the multimodal imaging of a case of long-lasting corneal endothelial graft rejection successfully reversed 3 months after dexamethasone intravitreal implant. A 29-year-old Asian female presented with a long-lasting corneal endothelial graft rejection in her left phakic eye. She underwent penetrating keratoplasty for advanced keratoconus 24 months before presentation. Hourly dexamethasone eyedrops, daily intravenous methylprednisolone, and one parabulbar injection of methylprednisolone acetate were administered during the 5 days of hospitalization. However, the clinical picture remained approximately unchanged despite therapy. By mutual agreement, we opted for the off-label injection of dexamethasone 0.7 mg intravitreal implant in order to provide therapeutic concentrations of steroid for a period of ~6 months. No other concomitant therapies were prescribed to the patient. Visual acuity measurement, slit lamp biomicroscopy, anterior segment photography, confocal microscopy, anterior segment optical coherence tomography, laser cell flare meter, intraocular pressure measurement, and ophthalmoscopy were performed monthly for the first postoperative 6 months. Three months after injection, both clinical and subclinical signs of rejection disappeared with a full recovery of visual acuity to 20/30 as before the episode. Currently, at the 12-month

  1. Conservative treatment of coexisting microinvasive squamous and adenocarcinoma of the cervix: report of two cases and literature review

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    Sopracordevole F

    2016-01-01

    Full Text Available Francesco Sopracordevole,1,* Jacopo Di Giuseppe,2,* Silvia Cervo,3,4 Monica Buttignol,1 Giorgio Giorda,1 Andrea Ciavattini,2 Vincenzo Canzonieri3,5 1Gynecologic Oncology Unit, Department of Surgical Oncology, CRO Aviano National Cancer Institute, Aviano, Pordenone, 2Woman’s Health Sciences Department, Gynaecologic Section, Polytechnic University of Marche, Ancona, 3CRO-Biobank, 4Clinical Cancer Pathology, 5Pathology Unit, CRO Aviano National Cancer Institute, Aviano, Pordenone, Italy *These authors contributed equally to this work Abstract: Coexistence of microinvasive squamous cell carcinoma (MISCC and microinvasive adenocarcinoma (MIAC of the cervix is a rare phenomenon with very few clinically significant cases described in the literature. While a conservative approach has been studied, and may be effective in MISCC, a lower number of studies that recommend conservative treatment are available for MIAC. We report two cases of synchronous cervix lesions in two separate foci, MISCC and MIAC, who underwent fertility-sparing treatment with long-term follow-up. We describe clinical, histological, and immunohistochemical features of the two cases. The first case is a 41-year-old female with a diagnosis of MIAC of endocervical type, grade 1 differentiation, with a stromal invasion, associated with a separate area of squamous cell carcinoma (International Federation of Gynecology and Obstetrics/TNM stage: pT1a1G1. The second case is a 45-year-old female with a diagnosis of plurifocal MISCC, associated with an MIAC of endocervical type with a stromal invasion (International Federation of Gynecology and Obstetrics/TNM stage: pT1a1G1. After multidisciplinary counseling, both patients accepted conization as definitive treatment. Eleven years after the conization, all tests (Papanicolaou smear, colposcopy, cervical curettage, and hybrid capture 2-human papillomavirus test planned quarterly in the first year and every 6 months in the subsequent years

  2. Editorial

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    B. Rossaro

    2015-08-01

    Full Text Available The Journal of Entomological and Acarological Research (JEAR, formerly the Bollettino di Zoologia Agraria e di Bachicoltura of the Institute of Entomology of the University of Milan, was founded in 1928 by Remo Grandori (1928-1955. Prof. Grandori became the first Director of the journal, followed by his wife Luigia Grandori (1956-1957, Minos Martelli (1958-1985 and Luciano Süss (1986-2011. In 2012, the Editor, the Department of Agri-food Systems Protection (DiPSA - University of Milan, come to the decision to move from the paper version to the online open access version of JEAR, with the aim to reach all researchers in the field with a restyled editorial, and with Giuseppe Carlo Lozzia as Editor in Chief (2012-2014. Thanks to the contributions of prestigious scientists and young researchers from all over the world, the Journal published many papers, which were downloaded in numerous countries across the world. Recently, the new Editor, the Department of Food Environmental and Nutritional Sciences - University of Milan, named me as Editor-in-Chief and I happily accepted the invitation with the objective to give new energy to the JEAR through the publication of more and more research papers of recognized scientific quality. The Journal will maintain its actual structure with four subject areas steered by internationally recognized Section Editors, who are now supported by a new and larger Editorial Board. The JEAR publishes papers on systematics, geographical speciation and evolution, aquatic and terrestrial entomology, ecological system dynamics, phenology and modelling for integrated pest control, agricultural and stored product pests, urban veterinary and forensic entomology, plant insect interaction and ecosystems, biological control and agro-ecology, and all other subjects related to the four subject areas. I hope the journal will continue to receive the attention of the researchers, in particular our younger colleagues in whose hands is

  3. PORTRAIT GRAFFITI IN MARGINS OF ANTIQUE LITHUANIAN BOOKS

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    Burba, Domininkas

    2006-12-01

    discharge. The marginal portraits in personal books are more artistical and their composition is more relaxed. Overall the GDL marginal portraits reveal quite a few similarities to the graffiti (in italian scarabocchi left in the documents by the workers of Naples bank archive. They were properly examined and classified by the artist and archivist Giuseppe Zevola. According to him this documental graffiti was born out of opposition to the grey everyday routine and experience of “pleasure of anxiety”.

  4. PhD Dissertations Tesi di dottorato

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    Redazione Reti Medievali (a cura di

    2002-06-01

    Full Text Available

    Report of PhD dissertation.

    Laura Baietto

    Una politica per le città. Rapporti fra papato, vescovi e comuni nell'Italia centro-settentrionale da Innocenzo III a Gregorio IX, Tesi di dottorato di ricerca in Storia Medievale, Università degli Studi di Torino, 2002

     

    Giuseppe Banfo

    Compresenze e sovrapposizioni di poteri territoriali di qualità diversa tra X e XIII: il caso del basso Monferrato, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Torino, 2002

     

    Francesca Dell'Acqua

    La vetrata tra l'età tardo imperiale e l'altomedioevo: le fonti, l'archeologia, Tesi di Perfezionamento in Storia dell'Arte Medievale, Scuola Normale Superiore di Pisa, 2001

     

    Primo Giovanni Embriaco

    I vescovi di Albenga e gli sviluppi signorili nella Liguria occidentale (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Torino, 2001

     

    Antonella Ghignoli

    Documenti e proprietà altomedievali. Fondamenti e problemi dell'esegesi storica delle fonti documentarie nello specchio della tradizione delle carte pisane dei secoli VIII-XI, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Firenze, 2002

     

    Vito Loré

    Espansione monastica e mutamenti politici. La Trinità di Cava nei suoi rapporti con i sovrani longobardi e normanni e con l'aristocrazia territoriale. Secoli XI-XII, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Firenze, 2002

     

    Rosaria Stracuzzi

    Messina nel '400, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Palermo, 2001

     

    Stefania Tamburini

  5. The role of melatonin in mood disorders

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    De Berardis D

    2015-11-01

    Full Text Available Domenico De Berardis,1–3 Laura Orsolini,3–5 Nicola Serroni,1 Gabriella Girinelli,1–3 Felice Iasevoli,3–6 Carmine Tomasetti,3–6 Monica Mazza,3–7 Alessandro Valchera,3–8 Michele Fornaro,9 Giampaolo Perna,10–12 Monica Piersanti,13Marco Di Nicola,14 Marilde Cavuto,15 Giovanni Martinotti,2 Massimo Di Giannantonio21NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G Mazzini", Teramo, Italy; 2Department of Neuroscience, Imaging and Clinical Science, Chair of Psychiatry, University G d'Annunzio, Chieti, Italy; 3Polyedra, Teramo, Italy; 4United Hospitals, Academic Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy; 5School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Hertfordshire, UK; 6Laboratory of Molecular Psychiatry and Psychopharmacotherapeutics, Section of Psychiatry, Department of Neuroscience, University School of Medicine Federico II, Naples, Italy; 7Department of Health Sciences, University of L'Aquila, L'Aquila, Italy; 8Villa S Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy; 9Department of Scienze della Formazione, University of Catania, Catania, Italy; 10Hermanas Hospitalarias, FoRiPsi, Department of Clinical Neurosciences, Villa San Benedetto Menni, Albese con Cassano, Como, Italy; 11Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, the Netherlands; 12Department of Psychiatry and Behavioral Sciences, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA; 13Hospital Pharmacy, Hospital G Mazzini, ASL 4 Teramo, Italy; 14Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, Italy; 15IASM, L'Aquila, ItalyAbstract: Melatonin (N-acetyl-5-methoxytryptamine has been discovered as a hormone secreted by the pineal gland, even though it is also synthetized in various other organs, tissues, and cells. The circadian rhythm of

  6. Safety, efficacy and patient satisfaction with continuous daily administration of levonorgestrel/ethinylestradiol oral contraceptives

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    Giuseppe Benagiano

    2009-04-01

    Full Text Available Giuseppe Benagiano, Sabina Carrara, Valentina FilippiDepartment of Gynaecology and Obstetrics, Sapienza University, Rome, ItalyAbstract: The progestational steroid norgestrel was synthesized and tested between 1960 and 1965 through an international cooperation between Wyeth, USA and Schering, Berlin. It is a mixture of two “enantiomers,” with only one form (designated as levonorgestrel biologically active. When taken orally, it is rapidly absorbed, not subjected to a “first-pass” effect and is approximately 90% bioavailable, with a circulating half-life around 15 hours. Its contraceptive action is exerted at the central (hypothalamic and peripheral (cervical mucus and endometrium levels. Levonorgestrel (LNG, alone or in combination with ethinyl estradiol (EE, is the most widely employed contraceptive progestin: it is used in combined oral contraceptives, progestogen-only pills, long-acting contraceptive implants, intrauterine contraceptive systems and in emergency contraception. It is also the steroid of choice for new oral contraceptive regimens aimed at reducing the frequency of bleeding episodes. This novel approach, already tried more than 30 years ago, gained interest around the year 2000 when surveys of women’s attitudes toward monthly menstrual bleeding started to show a major change: more and more women declared that they would welcome a hormonal contraceptive method that reduced bleeding episodes to 4, 2 or even 1 per year. At this point, while the debate on the significance and “usefulness” of menstruation went on, attention focused on new regimens. The first new modality consisted of changing the 7-day medication-free interval, either shortening it to fewer than 7 days, or by the administration of low-dose estrogens during the interval between packages. Then, continuous administration regimens started to be investigated. This, however, did not happen suddenly, since, in specific situations, doctors had for years

  7. Prevalence and clinical features associated with bipolar disorder polypharmacy: a systematic review

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    Fornaro M

    2016-03-01

    Full Text Available Michele Fornaro,1 Domenico De Berardis,2 Ann Sarah Koshy,3 Giampaolo Perna,4 Alessandro Valchera,5 Davy Vancampfort,6 Brendon Stubbs7,8 1New York Psychiatric Institute, Columbia University, New York, NY, USA; 2National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini”, Teramo, Italy; 3St. John’s National Academy of Health Sciences, Bangalore, India; 4Department of Clinical Neurosciences, Hermanas Hospitalarias - Villa San Benedetto Menni Hospital, FoRiPsi, 5Hermanas Hospitalarias, FoRiPsi Villa S. Giuseppe Hospital, Ascoli Piceno, Italy; 6Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium; 7Physiotherapy Department, South London and Maudsley NHS Foundation Trust, 8Health Service and Population Research Department, Institute of Psychiatry, King’s College London, London, UK Background: Uncertainty exists regarding the prevalence and clinical features associated with the practice of polypharmacy in bipolar disorder (BD, warranting a systematic review on the matter.Methods: Three authors independently searched major electronic databases from inception till September 2015. Articles were included that reported either qualitative or quantitative data about the prevalence and clinical features associated with polypharmacy in adult cases of BD.Results: The operative definitions of polypharmacy adopted across varying studies varied, with concomitant use of two or more psychotropic medications or use of four or more psychotropic medications at once being the most common and the most reliable, respectively. Regardless of type or current mood episode polarity of BD, prevalence rates up to 85% and 36% were found using the most permissive (two or more medications at once and the most conservative (four or more operative definitions for polypharmacy, respectively. Point prevalence prescription rates of one or more antidepressant or antipsychotic as part of a polypharmacy

  8. ‘If we want things to stay as they are, things will have to change’

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    Giovanni Savini

    2013-03-01

    Full Text Available ‘If we want things to stay as they are, things will have to change’"Se vogliamo che tutto rimanga come è, bisogna che tutto cambi"(Il gattopardo, Giuseppe Tomasi di LampedusaIt is now few months that I have been appointed as new editor in chief of the Veterinaria Italiana and first of all I would like to express my sincerest gratitude to Ferdinando Arnolfo, the Director of the Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise ‘G. Caporale’, and his staff for the honour they have bestowed on me. It is for me a very new and exciting challenge. I firmly believe the journal has the potential to turn into a successful and important voice in the scientific veterinary community. As you might be aware, Veterinaria Italiana is an indexed journal that recently received the impact factor, thus acquiring international recognition alongside major scientific journals.In view of this, it is only right and proper to acknowledge the previous team for their collective work for bringing the journal to its the current position. First of all, I would like to thank the previous director, Vincenzo Caporale, who has always strongly believed in Veterinaria Italiana, putting in a great deal of effort and resources when others doubted the success of this initiative. Special thanks are also due to the previous associate editor, Gill Dilmitis, who has been one of the pillars of the journal taking care of all author needs always with extreme enthusiasm and competency. I am afraid that Mariarosaria Taddeo, the new associate editor, and I will have the daunting task of meeting their high standards and level of competence; even more so because we realise that, as in numerous other activities, it is easy to start but it is always harder to maintain the status quo. Nonetheless, if on one hand we know that it is a difficult task, on the other hand we are sure that we and the other team members will do our best to improve the current position of the journal

  9. PREFACE: DICE 2006—Quantum Mechanics between Decoherence and Determinism

    Science.gov (United States)

    Diósi, Lajos; Elze, Hans-Thomas; Vitiello, Giuseppe

    2007-06-01

    and sponsors generously supported the workshop and their representatives and, in particular, the citizens of Piombino are deeply thanked for the hospitality: G. Anselmi (Sindaco del Comune di Piombino), O. Dell'Omodarme (Assessore alle Culture), A. Tempestini (Assessore alla Pubblica Istruzione), E. Murzi (Assessore al Turismo), A. Falchi (Dirigente dei Servizi Educativi e Culturali), M. Gianfranchi (Responsabile del Servizio Promozione Culturale), T. Ghini (Ufficio Beni Culturali), and L. Grilli, C. Boggero and P. Venturi (Ufficio Cultura), M. Pierulivo (Segreteria del Sindaco), L. Pasquinucci (URP e Comunicazione). Thanks go to Idearte (Cooperativa di Servizi Culturali) and especially to L. Pesce (Vitrium Galleria, Populonia). Funds made available by Universitá di Pisa (Centro Interdisciplinare per lo Studio dei Sistemi Complessi -- CISSC and Domus Galilaeana) and Universitá di Salerno (Dipartimento di Fisica and INFN) are gratefully acknowledged. The research papers presented at the workshop, often incorporating further developments since then, have been edited by L. Diósi, H.-T. Elze and G. Vitiello. They are collected here, essentially following the program of the workshop, however, divided into Invited Lectures and Contributed Papers, respectively. In the name of all participants, we would like to thank G. Douglas (IOP Publishing, Bristol) for his friendly advice and immediate help during the editing process. Lajos Diósi, Hans-Thomas Elze and Giuseppe Vitiello Budapest, Pisa, Salerno, March 2007 1Decoherence and Entropy in Complex Systems ed H-T Elze Lecture Notes in Physics 633 (Berlin: Springer, 2004) 2Proceedings of the Second International Workshop on Decoherence, Information, Complexity and Entropy DICE 2004 ed H-T Elze Braz. J. Phys. 35, 2A and 2B (2005) pp 205 529 freely accessible at: www.sbfisica.org.br/bjp

  10. The role of national regulations in RPAS-based mapping projects in the monitoring of natural hazards that could involve infrastructures: the example of the Val Venosta Railway (Northern Italy - Bolzano).

    Science.gov (United States)

    Gandolfo, Luca; Busnardo, Enrico; Castellarin, Nicola; Canella, Claudio; Canella, Federico; Stabile, Marco; Curci, Francesco; Petrillo, Giovanni

    2016-04-01

    Italy has adopted National Regulations for the use of RPAS in its country's airspace in December 2013, issued by the Italian Civil Aviation Authority (ENAC). Despite the issued regulations, over the past months an increasing number of unauthorized and unsafe operations have been performed and the attention to safety is growing quickly in the public opinion. For this reason "Critical Operations" is permitted only to those RPAS Operators which have received special authorization by ENAC after a very demanding Aeronautical procedure. According to the Regulations, the flight close to-over urban areas, industrial plants, highways and railways, implies that only authorized RPAS Operators may perform such activities. An example of a "Critical" operation were the RPAS flights performed along the Venosta railway line to evaluate the current situation of two areas affected by geological instability and laid the basis for a future high accurate monitoring. The Venosta Valley is located in the western part of South Tyrol (Norhtern Italy). The valley possesses some unique features compared to the entire Alps, the particularly dry climate and the presence of huge alluvional fans, which give rise to different levels of altitude in the valley. From geological point of view, the Venosta Valley is characterized by the presence of the Austroalpine domain. In particular, there are two different geological units in this area: (i) the crystalline schists of the basement, which includes paragneiss, gneiss, granitoid pegmatites, garnet micaschists, quartzites and phyllites. (ii) The Mesozoic coverage divided into various complexes with successions of phyllites, volcanics and magmatiti. The railway line that runs through the Venosta Valley (Merano - Malles) unfolds along a path of 59,8 kilometers and covers an altitude difference of about 700 meters. In particular, three tunnels characterized the first section, including the M. Giuseppe tunnel, which required extensive consolidations both

  11. Effectiveness, durability, and safety of darunavir/ritonavir in HIV-1-infected patients in routine clinical practice in Italy: a postauthorization noninterventional study

    Directory of Open Access Journals (Sweden)

    Antinori A

    2016-05-01

    Full Text Available Andrea Antinori,1 Paola Meraviglia,2 Antonella d’Arminio Monforte,3,4 Antonella Castagna,5,6 Cristina Mussini,7 Teresa Bini,4 Nicola Gianotti,5 Stefano Rusconi,8 Elisa Colella,8 Giuseppe Airoldi,9 Daniela Mancusi,10 Roberta Termini10 1Clinical Department, National Institute for Infectious Diseases “L. Spallanzani”, Rome, 2Department of Infectious Disease, “L. Sacco” University Hospital, 3Department of Health Sciences – University of Milan, 4Clinic of Infectious Diseases, “San Paolo” Hospital, 5Infectious Diseases, San Raffaele Scientific Institute, 6Università Vita-Salute San Raffaele, Milan, 7Institute of Infectious Diseases, University of Modena and Reggio Emilia, Modena, 8Infectious Diseases Unit, DIBIC Luigi Sacco, University of Milan, 9Studio Associato Airoldi, Cicogna, Ghirri, 10Janssen-Cilag SpA, Medical Affairs, Cologno Monzese, Milan, Italy Abstract: Current antiretroviral (ARV therapy for the treatment of human immunodeficiency virus (HIV-1-infected patients provides long-term control of viral load (VL. Darunavir (DRV is a nonpeptidomimetic protease inhibitor approved for use with a ritonavir booster (DRV/r. This study evaluated the effectiveness of DRV/r in combination with other ARV agents in routine clinical practice in Italy. In this descriptive observational study, data on utilization of DRV/r, under the conditions described in the marketing authorization, were collected from June 2009 to December 2012. Effectiveness (VL <50 copies/mL, tolerability, and durability in four patient groups (two DRV/r-experienced, one ARV-experienced DRV/r-naïve, and one ARV-naïve were analyzed. Secondary objectives included immunological response, safety, and persistence/discontinuation rates. In total, 875 of 883 enrolled patients were included in the analysis: of these, 662 (75.7% completed the follow-up until the end of 2012 and 213 (24.3% withdrew from the study earlier. Initial DRV dose was 600 mg twice daily (67.1% or 800

  12. L’abate Angelo Comolli (1760-1794 e il confronto Raffaello-Dürer

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    Stefano Onofri

    2012-02-01

    Full Text Available L’articolo studia l’abate Angelo Comolli e la sua Vita inedita di Raffaello da Urbino, pubblicata per la prima volta a Roma nel 1790. Di questa biografia è interessante, in particolare, il brano sul confronto tra Raffaello e Dürer. Non si sa molto della vita dell’abate Comolli: possiamo ricavarne alcune informazioni da una lettera (Torino, Biblioteca Civica scritta dal fratello Fermo. Nel suo lavoro su Raffaello, Comolli dichiara di pubblicare con note un’anonima biografia del pittore urbinate, scritta prima del Vasari e trovata in un manoscritto del XVI secolo proveniente dalla Certosa di Pavia. Sul frontespizio dell’edizione del 1790 è raffigurata una medaglia (in quegli anni conservata a Roma, nella collezione di monsignor Giuseppe Muti Papazzurri già Casali ed ora a Londra, British Museum con un ritratto di Raffaello sul dritto, e sul rovescio una Diana polimaste, simbolo della forza generatrice della Natura, associata ad una frase tratta dal distico del Bembo sulla tomba di Raffaello: Timuit quo sospite vinci; un’iconografia che simboleggia l’ideale disputa tra la Natura e l’arte di Raffaello. Oggi sappiamo che la biografia del Comolli è un falso ricalcato sulle Vite del Vasari; Anton Springer lo dimostrò accuratamente nel 1882. Ma ebbe comunque un certo successo: fu pubblicata di nuovo a Roma nel 1791; nel 1817 fu tradotta in tedesco dall’archivista Maximilian Prokop von Freyberg e pubblicata a Monaco; Ingres si ispirò alla Vita del Comolli quando dipinse due scene tratte dalla biografia del pittore urbinate (Raffaello e la Fornarina e Il fidanzamento di Raffaello; Gaetano Milanesi, nella sua edizione delle Vite del Vasari del 1879, ancora considerò la Vita del Comolli come un documento autentico. L’abate Comolli si mostra erudito, nelle note alla sua biografia di Raffaello e nell’altro suo lavoro, la Bibliografia storico-critica dell’architettura civile ed arti subalterne, pubblicata sempre a Roma negli

  13. Radiological response and survival in locally advanced non-small-cell lung cancer patients treated with three-drug induction chemotherapy followed by radical local treatment

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    Bonanno L

    2016-06-01

    Full Text Available Laura Bonanno,1 Giulia Zago,1 Giuseppe Marulli,2 Paola Del Bianco,3 Marco Schiavon,2 Giulia Pasello,1 Valentina Polo,1,4 Fabio Canova,1 Fabrizio Tonetto,5 Lucio Loreggian,5 Federico Rea,2 PierFranco Conte,1,4 Adolfo Favaretto1 1Medical Oncology Unit 2, Veneto Institute of Oncology IOV-IRCCS, 2Thoracic Surgery Department, University of Padova, 3Clinical Trials and Biostatistics Unit, Veneto Institute of Oncology IOV-IRCCS, 4Department of Surgery, Oncology and Gastroenterology, University of Padova, 5Radiotherapy Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy Objectives: If concurrent chemoradiotherapy cannot be performed, induction chemotherapy followed by radical-intent surgical treatment is an acceptable option for non primarily resectable non-small-cell lung cancers (NSCLCs. No markers are available to predict which patients may benefit from local treatment after induction. This exploratory study aims to assess the feasibility and the activity of multimodality treatment, including triple-agent chemotherapy followed by radical surgery and/or radiotherapy in locally advanced NSCLCs. Methods: We retrospectively collected data from locally advanced NSCLCs treated with induction chemotherapy with carboplatin (area under the curve 6, d [day]1, paclitaxel (200 mg/m2, d1, and gemcitabine (1,000 mg/m2 d1, 8 for three to four courses, followed by radical surgery and/or radiotherapy. We analyzed radiological response and toxicity. Estimated progression-free survival (PFS and overall survival (OS were correlated to response, surgery, and clinical features. Results: In all, 58 NSCLCs were included in the study: 40 staged as IIIA, 18 as IIIB (according to TNM Classification of Malignant Tumors–7th edition staging system. A total of 36 (62% patients achieved partial response (PR, and six (10% progressions were recorded. Grade 3–4 hematological toxicity was observed in 36 (62% cases. After chemotherapy, 37 (64% patients underwent surgery

  14. Skeletal muscle lipid quantification in lean and diabetic subjects using in vivo proton MR spectroscopy

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    Sunil K Valaparla

    2014-03-01

    : Valaparla SK, Boone GRE, Ripley EM, Giuseppe D, Duong TQ, Abdul-Ghani M, Clarke GD. Skeletal muscle lipid quantification in lean and diabetic subjects using in vivo proton MR spectroscopy. Int J Cancer Ther Oncol 2014; 2(2:020239. DOI: 10.14319/ijcto.0202.39

  15. Prof. Dr. Mithad Kozličić – Member of the Academy of Sciences and Arts of Bosnia and Herzegovina

    Directory of Open Access Journals (Sweden)

    Miljenko Lapaine

    2013-06-01

    material and one intended for navigation, and charts by 12 cartographers produced between the beginning of the 13th century and the end of the 16th century are researched. The central chapter is dedicated to numerous cartographers and their perception of the Croatian Adriatic. The book contains basic map data, including toponymy, name of the collection and scientific and expert commentary. A list of bibliographic units and a terminology index can be found at the end. We would like to single out Professor Kozličić’s monographs Panoramas of Dalmatia by Giuseppe Rieger, published by the Hydrographic Institute of the Republic of Croatia, Split 2003, Regiones Flumina Unnae et Sanae in Veteribus Tabulis Geographicis, Una-Sana Area on Old Geographic Maps, published by the National and University Library of Bosnia and Herzegovina, Sarajevo and the Una-Sana Canton Archive, Bihać, 2003 and Eastern Adriatic in Work of Beautemps-Beaupré, published in 2006. Prof. Dr. Mithad Kozličić is a member of several expert societies, including the Croatian Cartographic Society, in which he was a member of the Court of Honour for several years. He received several awards and acknowledgments and this year became a member of the Academy of Sciences and Arts of Bosnia and Herzegovina (“a member outside of working team” – citizen of Bosnia and Herzegovina living abroad.Congratulations! 

  16. The «Natural Hazard WIKISAURUS»: explanation and understanding of natural hazards to build disaster resilience

    Science.gov (United States)

    Rapisardi, Elena; Di Franco, Sabina; Giardino, Marco

    2013-04-01

    In the Internet and Web 2.0 era, the need of information is increased. Moreover, recent major and minor disasters highlighted that information is a crucial element also in emergency management. Informing the population is now the focal point of any civil protection activity and program. Risk perception and social vulnerability become widely discussed issues "when a disaster occurs": a "day-after" approach that should be replaced by a "day-before" one. Is that a cultural problem? Is it a communication issue? As a matter of fact, nowadays academics, experts, institutions are called to be more effective in transferring natural hazards knowledge (technical, operational, historical, social) to the public, for switching from «protection/passivity» (focused on disaster event) to «resilience» (focused on vulnerability). However, this change includes to abandon the "Elites Knowledge" approach and to support "Open Knowledge" and "Open Data" perspectives. Validated scientific information on natural hazards is not yet a common heritage: there are several cases of misleading or inaccurate information published by media. During recent Italian national emergencies [Flash Floods Liguria-Toscana 2011, Earthquake Emilia-Romagna 2012], social media registered people not only asking for news on the disaster event, but also talking trivially about scientific contents on natural hazards. By considering these facts, in the framework of a phD program in Earth Science, a joint team UNITO-NatRisk and CNR-IIA conceived the web project "Natural Hazards Wikisaurus" [NHW], combining two previous experiences: "HyperIspro" - a wiki on civil protection set up by Giuseppe Zamberletti, former Italian minister of Civil Protection - and "Earth Thesaurus", developed by CNR-IIA. The team decided to start from the «words» using both the collaboration of the wiki concept (open and participatory knowledge) and the power of explanation of a thesaurus. Why? Because a word is not enough, as a term has

  17. Effects of an adapted physical activity program on psychophysical health in elderly women

    Directory of Open Access Journals (Sweden)

    Battaglia G

    2016-07-01

    Full Text Available Giuseppe Battaglia,1,2 Marianna Bellafiore,1,2 Marianna Alesi,1,2 Antonio Paoli,3 Antonino Bianco,1,2 Antonio Palma1,2 1Department of Psychological, Pedagogical and Educational Sciences, 2Sport and Exercise Sciences Research Unit, University of Palermo, Palermo, 3Department of Biomedical Sciences, University of Padova, Padua, Italy Background: Several studies have shown the positive effects of adapted physical activity (APA on physical and mental health (MH during the lifetime. The aim of this study was to assess the effectiveness of a specific APA intervention program in the improvement of the health-related quality of life (QOL and functional condition of spine in elderly women. Methods: Thirty women were recruited from a senior center and randomly assigned to two groups: control group (CG; age: 69.69±7.94 years, height: 1.57±0.06 m, weight: 68.42±8.18 kg, body mass index [BMI]: 27.88±2.81 and trained group (TG; age: 68.35±6.04 years, height: 1.55±0.05 m, weight: 64.78±10.16 kg, BMI: 26.98±3.07. The APA program was conducted for 8 weeks, with two training sessions/week. CG did not perform any physical activity during the study. Spinal angles were evaluated by SpinalMouse® (Idiag, Volkerswill, Switzerland; health-related QOL was evaluated by SF-36 Health Survey, which assesses physical component summary (PCS-36, mental component summary (MCS-36, and eight subscales: physical functioning, role-physical, bodily pain, general health perception, role-emotional, social functioning, vitality, and MH. All measures were recorded before and after the experimental period. Results: In TG, compared to CG, the two-way analysis of variance with repeated measures with Bonferroni post hoc test showed a relevant improvement in lumbar spinal angle (° and in SF-36 outcomes after the intervention period. We showed a significant increase in physical functioning, bodily pain, and MH subscales and in PCS-36 and MCS-36 scores in TG compared to CG. In

  18. Prevalence of risk factors, coronary and systemic atherosclerosis in abdominal aortic aneurysm: Comparison with high cardiovascular risk population

    Directory of Open Access Journals (Sweden)

    Alberto Palazzuoli

    2008-08-01

    Full Text Available Alberto Palazzuoli, Maddalena Gallotta, Giuseppe Guerrieri, Ilaria Quatrini, Beatrice Franci, et alDepartment of Internal Medicine and Metabolic Diseases, Unit of Aortic Surgery, University of Siena, ItalyBackground: Abdominal aortic aneurysm (AAA is considered a manifestation of atherosclerosis, however there are epidemiologic, biochemical, and structural differences between occlusive atherosclerosis and AAA. The pathogenesis of AAA involves several factors, first of all destruction of collagen and elastin in the aortic wall. Classical risk factors may influence the evolution and development of AAA, though no consistent association has been found. Aims of the study were to evaluate associations between risk factors and to establish the prevalence of carotid, peripheral vascular and coronary atherosclerosis in patients with AAA.Methods: We studied 98 patients with AAA (Group 1 awaiting surgery compared with high cardiovascular risk population having two or more risk factors (n = 82 Group 2. We evaluated traditional risk factors and we studied by eco-doppler and echocardiography the presence of carotid peripheral and coronaric atherosclerosis in two groups.Results: We found a higher incidence of AAA in males (p < 0.01. The prevalence of infrarenal AAA was significantly higher than suprarenal AAA (81 vs 17 p < 0.001. No differences in total cholesterol (199 ± 20 vs. 197 ± 25 mg/dl, low-density lipoprotein (142 ± 16 vs. 140 ± 18 mg/dl, triglycerides (138 ± 45 vs. 144 ± 56 mg/dl, glycemia (119 ± 15 vs. 122 ± 20 mg/dl, and fibrinogen (388 ± 154 vs. 362 ± 92 mg/dl were found between groups. We demonstrated significant differences for cigarette smoking (p < 0.002, systolic and diastolic blood pressure (150 ± 15 vs. 143 ± 14 mmHg and 88 ± 6 vs. 85 ± 7 mmHg, p < 0.0001 and p < 0.05, respectively and high sensititivity C reactive protein (2.8 ± 1.3 vs. 1.3 ± 0.7 mg/dl, p < 0.001. High-density lipoprotein (HDL cholesterol levels were

  19. VizieR Online Data Catalog: New standards in 18th century astrometry (Lequeux, 2014)

    Science.gov (United States)

    Lequeux, J.

    2014-05-01

    named lacaillefund.dat. La Caille's complete survey of the southern sky (lacaisur.dat): During his stay in Cape Town in 1751-1752, La Caille made the first systematic survey of the sky ever, in the modern sense. 244 stars over 9766. La Caille's catalogue of zodiacal stars (lacaizod.dat): When La Caille returned from his southern expedition in 1754, he undertook the construction of a catalogue of zodiacal stars. Mayer's zodiacal catalogue (mayer.dat): At exactly the same time as La Caille, Tobias Mayer (1723-1762) in Gottingen undertook a similar catalogue of zodiacal stars, using a 6-feet radius mural quadrant made by John Bird (1709-1776). 200 stars over 998. Bradley's stellar catalogue (bradley.dat): James Bradley (1693-1762) is famous for his discovery of aberration and nutation. From 1750 to his death in 1762, he built a large stellar catalogue, from observations first with an old mural sector and after 1753 with the Bird 8-ft mural sector located in Greenwich, where it 215 stars over 3220. Piazzi's stellar catalogue (piazzi.dat): Giuseppe Piazzi (1746-1846) built a large catalogue containing 7646 stars from 1792 to 1813, observed in Palermo with an altazimuthal circle of Jesse Ramsden (1735-1800) can still be seen. 202 stars over 7646. Lalande's stellar catalogue (lalande.dat): L'Histoire celeste francaise de Lalande (Lalande 1801), which contains the unreduced observations of approximately 40,000 stars, is the first very large stellar catalogue. 198 stars over ~45000. (10 data files).

  20. Selected Abstracts of the 22nd European Neonatal Workshop; Siena (Italy; Carthusia Pontiniani; June 15-18, 2014

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2014-06-01

    Full Text Available Selected Abstracts of the 22nd European Neonatal Workshop • Siena (Italy • Carthusia Pontiniani • June 15th-18th, 2014Guest Editor: Giuseppe BuonocoreABS 1. Incidence and risk factors of intraventricular hemorrhage (IVH in infants less than 32 weeks of gestation • G. Mitsiakos, A. Papageorgiou; Montreal (Canada ABS 2. Cord blood concentrations of the myokine irisin in fetal macrosomia • D.D. Briana, T. Boutsikou, M. Boutsikou, S. Baka, A. Marmarinos, D. Hassiakos, D. Gourgiotis, A. Malamitsi-Puchner; Athens (Greece ABS 3. Asynchronous chest compressions improve survival in a neonatal piglet model of asphyxial cardiac arrest • N. Iacovidou, A. Aggelina, A. Papalois, A. Douvanas, P. Pliatsika, T. Xanthos; Athens (Greece ABS 4. Human cytomegalovirus (CMV congenital infection. Implementation of a screening program during pregnancy • I. Dorronsoro, M. Lopez-Azorin, M. Caballero, J. García-Flores, M. Recio, A. Pellicer, F. Cabañas; Madrid (Spain ABS 5. Steps forward the BiAR-COH method in autoregulation analysis: assessment of causality • J. Riera, F. Cabañas, J.J. Serrano, M.C. Bravo, P. López-Ortego, L. Sánchez, R. Madero, A. Pellicer; Madrid and Zaragoza (Spain ABS 6. Comparison of delivery room care in three countries: There are many ways of skinning a cat • S. Walter, B. Simma, J. van Vonderen, A.B. te Pas, H. Küster; Göttingen (Germany, Feldkirch (Austria and Leiden (The Netherlands ABS 7. Diaphragmatic function in convalescent preterm infants with chronic lung disease • G. Dimitriou, A. Vervenioti, S. Fouzas, P. Pelekouda; Patras (Greece ABS 8. Stem/progenitors in the newborn kidney: an undiscovered resource to prevent kidney failure later in life? • G. Faa, C. Gerosa, A. Sanna, M. Puddu, D. Fanni, V. Fanos; Cagliari (Italy ABS 9. Placental histological patterns and oxidative stress in the offspring • S. Perrone, S. Negro, M.S. Cori, M.G. Alagna, P. Toti, M.S. Toti, C. Felici, M. Longini, M.L. Tataranno, G

  1. Bridging the gap between education and appropriate use of benzodiazepines in psychiatric clinical practice

    Directory of Open Access Journals (Sweden)

    Dell’Osso B

    2015-07-01

    Full Text Available Bernardo Dell’Osso,1,2,* Umberto Albert,3,* Anna Rita Atti,4 Claudia Carmassi,5 Giuseppe Carrà,6 Fiammetta Cosci,7 Valeria Del Vecchio,8 Marco Di Nicola,9 Silvia Ferrari,10 Arianna Goracci,11 Felice Iasevoli,12 Mario Luciano,8 Giovanni Martinotti,13 Maria Giulia Nanni,14 Alessandra Nivoli,15,16 Federica Pinna,17 Nicola Poloni,18 Maurizio Pompili,19 Gaia Sampogna,8 Ilaria Tarricone,20 Sarah Tosato,21 Umberto Volpe,8 Andrea Fiorillo8 1Department of Psychiatry, University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 2Bipolar Disorders Clinic, Stanford Medical School, Stanford University, CA, USA; 3Rita Levi Montalcini Department of Neuroscience, University of Turin, Torino, 4Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, 5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 6Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK; 7Department of Health Sciences, University of Florence, Florence, 8Department of Psychiatry, University of Naples SUN, Naples, 9Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, 10Department of Diagnostic-Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Modena, 11Department of Molecular Medicine and Clinical Department of Mental Health, University of Siena, Siena, 12Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Federico II of Naples, Naples, 13Department of Neuroscience, Imaging, and Clinical Science, University G.d Annunzio, Chieti-Pescara, 14Section of Psychiatry, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, 15Psychiatric Institute, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy; 16Bipolar Disorder Unit, CIBERSAM, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain; 17Department of

  2. Osimertinib in the treatment of non-small-cell lung cancer: design, development and place in therapy

    Directory of Open Access Journals (Sweden)

    Santarpia M

    2017-08-01

    Full Text Available Mariacarmela Santarpia,1 Alessia Liguori,1 Niki Karachaliou,2 Maria Gonzalez-Cao,3 Maria Grazia Daffinà,1 Alessandro D’Aveni,1 Grazia Marabello,1 Giuseppe Altavilla,1 Rafael Rosell3–5 1Medical Oncology Unit, Department of Human Pathology “G. Barresi”, University of Messina, Messina, Italy; 2Institute of Oncology Rosell (IOR, University Hospital Sagrat Cor, 3Department of Oncology, Institute of Oncology Rosell (IOR, Quirón-Dexeus University Institute, Barcelona, 4Cancer Biology and Precision Medicine Program, Germans Trias i Pujol Research Institute, 5Catalan Institute of Oncology, Germans Trias i Pujol University Hospital, Badalona, Spain Abstract: The discovery of epidermal growth factor receptor (EGFR mutations and subsequent demonstration of the efficacy of genotype-directed therapies with EGFR tyrosine kinase inhibitors (TKIs marked the advent of the era of precision medicine for non-small-cell lung cancer (NSCLC. First- and second-generation EGFR TKIs, including erlotinib, gefitinib and afatinib, have consistently shown superior efficacy and better toxicity compared with first-line platinum-based chemotherapy and currently represent the standard of care for EGFR-mutated advanced NSCLC patients. However, tumors invariably develop acquired resistance to EGFR TKIs, thereby limiting the long-term efficacy of these agents. The T790M mutation in exon 20 of the EGFR gene has been identified as the most common mechanism of acquired resistance. Osimertinib is a third-generation TKI designed to target both EGFR TKI-sensitizing mutations and T790M, while sparing wild-type EGFR. Based on its pronounced clinical activity and good safety profile demonstrated in early Phase I and II trials, osimertinib received first approval in 2015 by the US FDA and in early 2016 by European Medicines Agency for the treatment of EGFR T790M mutation-positive NSCLC patients in progression after EGFR TKI therapy. Recent results from the Phase III AURA3

  3. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2005-12-01

    Full Text Available Report of PhD Dissertations.Anna Airò La scrittura delle regole. Politica e istituzioni a Taranto nel Quattrocento, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Pasquale Arfé La Clavis Physicae II (316-529 di Honorius Augustodunensis. Studio ed edizione critica, Tesi di dottorato in Storia della filosofia medievale, Università degli Studi di Napoli "L'Orientale", 2005 Alessandro Azzimonti Scrittura agiografica e strutture di potere nell'Italia centro-settentrionale (X-XII secolo, Tesi di dottorato di ricerca in Forme del sapere storico dal medioevo alla contemporaneità, Università degli Studi di Trieste, 2004 Domenico Cerami Il "Confine conteso". Uomini, istituzioni, culture a Monteveglio tra VIII-XII secolo, Tesi di dottorato di ricerca in Storia Medievale, Università degli studi di Bologna, 2005 Federica Chilà Ostaggi. Uno strumento di pacificazione e governo tra i secoli VIII e XII, Tesi di dottorato di ricerca in Istituzioni, società, religioni dal Tardo Antico alla fine del Medioevo, Università degli Studi di Torino, 2004 Enrico Faini Firenze nei secoli X-XIII: economia e società, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005Alessio FioreStrutture e pratiche del potere signorile in area umbro-marchigiana (secoli XI-XIII, Tesi di dottorato ricerca in Storia, Università degli studi di Pisa, 2004Giampaolo FrancesconiTra Riforma, vescovo e clientes. Camaldoli e le società locali (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 [09/05] Giuseppe Gardoni "Episcopus et potestas". Vescovi e società a Mantova nella prima metà del Duecento, Tesi di dottorato di ricerca in Storia del Cristianesimo e delle Chiese (antichità, medioevo, età moderna, Università degli Studi di Padova, 2005 Nicola Mancassola La gestione delle campagne tra Langobardia e Romània in età carolingia e post

  4. De gevel – een intermediair element tussen buiten en binnen: Over het tonen en vertonen van het twintigste-eeuwse woongebouw in Nederland

    Directory of Open Access Journals (Sweden)

    Birgit Jürgenhake

    2016-11-01

    disappearance of city walls and gates after 1874 as a consequence of the vestigingswet [‘Settlement Act’], which allowed non-residents into the city or town without checks, and when the front door was established as the border between the public and the private. The façade became a necessary border between the public and the private. The street lost its importance as public space for those living on it as traffic increased. The introduction of the residential building only increased the distance to the street. The anonymization of the street also played a large role throughout the whole of the twentieth century. The functionalists rejected the street and wanted to connect homes with recreation and green spaces. Urban blocks of buildings were opened up as was the layout of residential buildings. This resulted in residential buildings which had several façades which were visible to the public. In the seventies, some architects, like Herman Hertzberger, returned the street to the resident and a pedestrian friendly zone in front of homes (the woonerf was created. The house façades on the residential areas allowed openness and space to be seen, fusing the public and the private. This approach was quickly followed by a reintroduction of a distance to the street. The last two decades of the twentieth century were characterised by a withdrawal of the social filter role to behind the façade. The street’s role as part of the home can only be found in very protected environments.The façade and private living (chapter 7 Private living was initially led by an increasing embarrassment and hygiene. The need to retreat further into the house gave rise to a more differentiated layout even in the traditional house and this can be read from the façade. In the second half of the nineteenth century, the privacy of the home was lost when it was housed with several others in the one building and by the internal entrance in a relatively open landing on the upper floors. The first two

  5. 5th National Congress of the Italian Society of Physiotherapy

    Directory of Open Access Journals (Sweden)

    Alessandro Aina

    2016-10-01

    Full Text Available Table of contents S1 Criteria for exercises selection in subjects with low back pain Alessandro Aina S2 Recent advances in pathophysiology and treatment of myofascial trigger points Marco Barbero S3 Rehabilitation of scapular dyskinesia Barbara Cagnie S4 Musculoskeletal rehabilitation in subjects affected by neurological disorders Elena Castelli S5 Which examination tests suggest the best candidates for manual therapy Chad Cook S6 Case study: the role of the measurements for the identification of targets and guidance of the treatment Silvano Ferrari S7 Assessment of joint mobility: state of the art Andrea Foglia, Paolo Bizzarri S8 Core stabilization exercises in the treatment of urinary incontinence Donatella Giraudo S9 Preventing surgical subacromial decompression through rotator cuff rehabilitation Chris Littlewood S10 Methodological aspects of Clinical Prediction Rules in the rehabilitation of Low Back Pain Paolo Pillastrini S11 Interpretability of outcome measures in musculoskeletal rehabilitation Daniele Piscitelli S12 Conservative treatment of the misalignment of the spine: state of the art and perspectives Michele Romano S13 Balance training in subjects with musculoskeletal disorders Andrea Tettamanti S14 Dosage of manual therapy: principles for clinical practice Carla Vanti S15 Are there speed limits in post-surgery lower limb rehabilitation? Stefano Vercelli S16 Classification of predominant neuropathic, nociceptive or central sensation pain Lennard Voogt P1 A wearable proprioceptive stabilizer (Equistasi® for rehabilitation of balance disorders in multiple sclerosis patients: preliminary results of a randomized, double-blind, versus placebo controlled study Aceto Maria, Spina Emanuele, Paone Paolo, Silvestre Francesco, Carotenuto Antonio, Cerillo Ilaria, Orefice Giuseppe P2 Effect of repeated neck retraction movements on strength and EMG activity of the upper limbs, range of motion and cervical posture Bassi Raffaele, Fiorito Serena

  6. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pharmacology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pharmacology”ABS 1. BABY SKIN CARE PRODUCTS • P. Doro, R. Abraham, D. Agoston, J. Balog, R.Z. CsomaABS 2. MATHEMATICAL MODELING TO PREDICT IN-HOSPITAL NATURAL WEIGHT CHANGES IN TERM NEONATES • S. Kasser, M. Wilbaux, C. De Angelis, H. Rickenbacher, N. Klarer, J.N. Van Den Anker, M. Pfister, S. WellmannABS 3. IMPROVING PARENTERAL NUTRITION IN THE NEONATE – A PRACTICAL GUIDELINE • H. Reigstad, D. Moster, I. Grønlie, A. BlystadABS 4. INVOLUTION OF RETINOPATHY OF PREMATURITY AND NEURODEVELOPMENTAL OUTCOME AFTER BEVACIZUMAB TREATMENT • Y.-S. Chang, P.-N. Tsao, C.-Y. Chen, H.-C. Chou, W.-S. Hsieh, P.-T. YehABS 5. RELATIONSHIP BETWEEN ADVERSE DRUG REACTIONS AND OFF-LABEL/UNLICENSED DRUG USE IN HOSPITALISED CHILDREN. EREMI STUDY • K.A. Nguyen, Y. Mimouni, A. Lajoinie, N. Paret, S. Malik, L. El-Amrani, L. Milliat-Guittard, C. Carcel, A. Portefaix, A.M. Schott, T. Vial, B. KassaiABS 6. A SYSTEMATIC REVIEW OF OFF-LABEL AND UNLICENSED DRUGS USE AND ADVERSE DRUG REACTIONS IN HOSPITALIZED CHILDREN • N. David, K.A. Nguyen, Y. Mimouni, A. Lajoinie, S. Malik, B. KassaiABS 7. EFFICACY AND SAFETY OF PROPOFOL SEDATION

  7. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Brain & Development”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Brain & Development”ABS 1. SEPARATE EFFECTS OF LOW PATERNAL AND MATERNAL EDUCATIONAL LEVEL ON RISK OF DEVELOPMENTAL DELAY IN 4-YEAR-OLD BOYS AND GIRLS • S. de Jong, M.R. Potijk, A.E. den Heijer, S.A. Reijneveld, A.F. Bos, J.M. KerstjensABS 2. THE ASSOCIATION BETWEEN PATERNAL EDUCATIONAL LEVEL AND DEVELOPMENTAL DELAY IN PRETERM AND TERM-BORN CHILDREN AT AGE 4 • S. de Jong, J.M. Kerstjens, A.E. den Heijer, A.F. Bos, S.A. Reijneveld, M.R. PotijkABS 3. NEUROPROTECTION BY NEURONAL OVEREXPRESSION OF THE SMALL GTPase-Ras IN HYPEROXIA-INDUCED NEONATAL BRAIN INJURY • M. Serdar, K. Kempe, J. Herz, R. Herrmann, B.S. Reinboth, R. Heumann, A. Ehrkamp, U. Felderhoff-Mueser, I. BendixABS 4. REFERENCE RANGES FOR CEREBRAL TISSUE OXYGEN INDEX (cTOI IN NEONATES DURING IMMEDIATE NEONATAL TRANSITION AFTER BIRTH • N. Baik, B. Urlesberger, B. Schwaberger, G. Schmölzer, A. Avian, L. Mileder, G. PichlerABS 4. REFERENCE RANGES FOR CEREBRAL TISSUE OXYGEN INDEX (cTOI IN NEONATES DURING IMMEDIATE NEONATAL TRANSITION AFTER BIRTH • N. Baik, B. Urlesberger, B. Schwaberger, G. Schmölzer, A. Avian, L. Mileder, G. PichlerABS 6. N

  8. Controllable Quantum States Mesoscopic Superconductivity and Spintronics (MS+S2006)

    Science.gov (United States)

    Takayanagi, Hideaki; Nitta, Junsaku; Nakano, Hayato

    2008-10-01

    Mesoscopic effects in superconductors. Tunneling measurements of charge imbalance of non-equilibrium superconductors / R. Yagi. Influence of magnetic impurities on Josephson current in SNS junctions / T. Yokoyama. Nonlinear response and observable signatures of equilibrium entanglement / A. M. Zagoskin. Stimulated Raman adiabatic passage with a Cooper pair box / Giuseppe Falci. Crossed Andreev reflection-induced giant negative magnetoresistance / Francesco Giazotto -- Quantum modulation of superconducting junctions. Adiabatic pumping through a Josephson weak link / Fabio Taddei. Squeezing of superconducting qubits / Kazutomu Shiokawa. Detection of Berrys phases in flux qubits with coherent pulses / D. N. Zheng. Probing entanglement in the system of coupled Josephson qubits / A. S. Kiyko. Josephson junction with tunable damping using quasi-particle injection / Ryuta Yagi. Macroscopic quantum coherence in rf-SQUIDs / Alexey V. Ustinov. Bloch oscillations in a Josephson circuit / D. Esteve. Manipulation of magnetization in nonequilibrium superconducting nanostructures / F. Giazotto -- Superconducting qubits. Decoherence and Rabi oscillations in a qubit coupled to a quantum two-level system / Sahel Ashhab. Phase-coupled flux qubits: CNOT operation, controllable coupling and entanglement / Mun Dae Kim. Characteristics of a switchable superconducting flux transformer with a DC-SQUID / Yoshihiro Shimazu. Characterization of adiabatic noise in charge-based coherent nanodevices / E. Paladino -- Unconventional superconductors. Threshold temperatures of zero-bias conductance peak and zero-bias conductance dip in diffusive normal metal/superconductor junctions / Iduru Shigeta. Tunneling conductance in 2DEG/S junctions in the presence of Rashba spin-orbit coupling / T. Yokoyama. Theory of charge transport in diffusive ferromagnet/p-wave superconductor junctions / T. Yokoyama. Theory of enhanced proximity effect by the exchange field in FS bilayers / T. Yokoyama. Theory of

  9. Time since plantation is the most important determining factor for soil erosion rates in vineyards. A case study in the valley of Les Alcusses valley, Eastern Spain

    Science.gov (United States)

    Rodrígo Comino, Jesús; Keesstra, Saskia; Novara, Agata; García Díaz, Andrés; Jordán, Antonio; Brevik, Eric C.; Cerdà, Artemi

    2017-04-01

    simulated rainfall events. Soil Res, 54, 2, 154-165 DOI: 10.1071/SR15092 Keesstra S, Pereira P, Novara A, Brevik EC, Azorin-Molina C, Parras-Alcántara L, Jordán A, Cerdà A. 2016. Effects of soil management techniques on soil water erosion in apricot orchards. Science of the Total Environment 551-552: 357-366. DOI: 10.1016/j.scitotenv.2016.01.182 Novara, A., A. Cerdà, D. Carmelo, L. P. Giuseppe, S. Antonino, and G. Luciano. 2015. Effectiveness of Carbon Isotopic Signature for Estimating Soil Erosion and Deposition Rates in Sicilian Vineyards. Soil and Tillage Research 152: 1-7. doi:10.1016/j.still.2015.03.010. Novara, A., L. Gristina, F. Guaitoli, A. Santoro, and A. Cerdà. 2013. Managing Soil Nitrate with Cover Crops and Buffer Strips in Sicilian Vineyards. Solid Earth 4 (2): 255-262. doi:10.5194/se-4-255-2013. Novara, A., L. Gristina, S. S. Saladino, A. Santoro, and A. Cerdà. 2011. Soil Erosion Assessment on Tillage and Alternative Soil Managements in a Sicilian Vineyard. Soil and Tillage Research 117: 140-147. doi:10.1016/j.still.2011.09.007. Prosdocimi, M., A. Cerdà, and P. Tarolli. 2016a. Soil Water Erosion on Mediterranean Vineyards: A Review. Catena 141: 1-21. doi:10.1016/j.catena.2016.02.010. Prosdocimi, M., A. Jordán, P. Tarolli, S. Keesstra, A. Novara, and A. Cerdà. 2016b. The Immediate Effectiveness of Barley Straw Mulch in Reducing Soil Erodibility and Surface Runoff Generation in Mediterranean Vineyards. Science of the Total Environment 547: 323-330. doi:10.1016/j.scitotenv.2015.12.076. Rodrigo Comino J, Iserloh T, Morvan X, Malam Issa O, Naisse C, Keesstra SD, Cerdà A, Prosdocimi M, Arnáez J, Lasanta T, Ramos MC, Marqués MJ, Ruiz Colmenero M, Bienes R, Ruiz Sinoga JD, Seeger M, Ries JB 2016a. Soil Erosion Processes in European Vineyards: A Qualitative Comparison of Rainfall Simulation Measurements in Germany, Spain and France. Hydrology, 3 (1), 6; doi:10.3390/hydrology3010006 Rodrigo Comino, J., Iserloh, T., Lassu, T., Cerdà, A., Keesstra, S

  10. Politiques et pratiques de la science en cour de Rome au temps des Lumières. Le renouveau méconnu des pontificats pio-clémentins (1769-1799

    Directory of Open Access Journals (Sweden)

    Gilles Montègre

    2011-09-01

    Full Text Available Souvent réduite à la figure de Benoît XIV, la politique de la cour de Rome en matière de science à l’époque des Lumières a connu d’importants développements dans la seconde moitié du siècle, au cours des pontificats de Clément XIV (1769-1774 et de Pie VI (1775-1799. La suppression de l’ordre des jésuites, imposée au Saint-Siège par les monarchies catholiques en 1773, engendra en effet une véritable recomposition de la politique pontificale en matière de science et de savoirs. Ce renouveau, confié à des prélats appelés à jouer un rôle croissant au sein de la Curie, impliqua des savants romains appartenant à divers ordres religieux, et bénéficia aux nombreux hommes de science étrangers de passage à Rome dans le cadre du Grand Tour.Dans le domaine des sciences mécaniques et astronomiques, le futur secrétaire d’état de Pie VI, François-Xavier Zelada, œuvra à la constitution d’un observatoire et d’un cabinet de physique expérimentale au Vatican, délibérément ouverts aux savants étrangers. Il permit ainsi à la ville de Rome de s’associer à la construction épistolaire du nouvel espace européen de relevés astronomiques engendré par la découverte de la planète Uranus. Zelada reprit également en main le Collegio Romano des anciens jésuites, appelant à y enseigner à des savants tels que le père minime François Jacquier, célèbre pour son commentaire latin des Principia de Newton. Dans le domaine médical, Pie VI créa à la Sapienza une nouvelle chaire d’obstétrique et de chirurgie, ce qui entraîna un accroissement du nombre des étudiants en médecine au sein de la célèbre université romaine. Le médecin du pape, Giuseppe Flajani, augmenta en outre les collections de cires anatomiques et multiplia les séances de dissection au sein l’hôpital Santo Spirito in Sassia, en les ouvrant au public des savants étrangers. Enfin, dans le domaine en voie de constitution des sciences

  11. Giant Galaxy Messier 87 finally sized up

    Science.gov (United States)

    2009-05-01

    population in general. As they are relatively short-lived (a few tens of thousands of years -- a mere blip on astronomical timescales), astronomers can estimate that one star in about 8000 million of Sun-like stars is visible as a planetary nebula at any given moment. Thus planetary nebulae can provide a unique handle on the number, types of stars and their motions in faint outer galaxy regions that may harbour a substantial amount of mass. These motions contain the fossil record of the history of galaxy interaction and the formation of the galaxy cluster. This research is presented in a paper to appear in Astronomy and Astrophysics: "The Edge of the M87 Halo and the Kinematics of the Diffuse Light in the Virgo Cluster Core," by Michelle Doherty et al. The team is composed of Michelle Doherty and Magda Arnaboldi (ESO), Payel Das and Ortwin Gerhard (Max-Planck-Institute for Extraterrestrial Physics, Garching, Germany), J. Alfonso L. Aguerri (IAC, Tenerife, Spain), Robin Ciardullo (Pennsylvania State University, USA), John J. Feldmeier (Youngstown State University, USA), Kenneth C. Freeman (Mount Stromlo Observatory, Australia), George H. Jacoby (WIYN Observatory, Tucson, AZ, USA), and Giuseppe Murante (INAF, Osservatorio Astronomico di Pino Torinese, Italy). ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in the Atacama Desert region of Chile: La Silla, Paranal and Chajnantor.

  12. INTRODUCTION: New trends in simulating colloids and self-assembling systems New trends in simulating colloids and self-assembling systems

    Science.gov (United States)

    Foffi, Giuseppe; Kahl, Gerhard

    2010-03-01

    University Of Oxford and Athanassios Panagiotopoulos—University Of Princeton) focused on the remarkable ability of colloidal systems to self-organize in well-defined composite objects. New simulation techniques and theoretical approaches were presented and discussed that offer a deeper understanding of self-assembly phenomena in colloidal physics and, eventually to uncover design rules for self-assembly. Particular emphasis was put on an emerging new class of colloidal particles, so-called patchy colloids. The second workshop, entitled 'New Trends in Simulating Colloids: From Models to Applications', (organized by Giuseppe Foffi—Ecole Polytechnique Fédérale De Lausanne, Gerhard Kahl—Vienna Technical University and Richard Vink—Georg-August-Universität Göttingen) focused on new methodological devices in theoretical and simulation approaches that provided a more profound insight in colloidal physics in general. A large variety of theoretical tools, ranging from different simulation techniques over classical density functional theory to efficient optimization techniques were presented. For details about the tools presented in both workshops we refer the reader to the contributions of this special issue. The 'round table' discussion meetings were highly useful in providing an overview of yet unsolved problems and to point out directions for future work. From the phenomenological point of view, among those are the question on the relevance of hydrodynamic interactions, the problem whether to treat solvents in an explicit or implicit way, or the relevance of multibody interactions, to name but a few. With respect to the methods it was agreed that future developments on dynamic Monte Carlo simulations or on rare events and multiscale techniques are urgently required. The presence of the experimentalists was also of great help in focusing attention on the systems that are going to represent the scientific challenges in the next years. It was interesting that while new

  13. Editorial: Focus on Dynamics and Thermalization in Isolated Quantum Many-Body Systems

    Science.gov (United States)

    Cazalilla, M. A.; Rigol, M.

    2010-05-01

    interaction quenches in the Hubbard model: prethermalization and non-equilibrium dynamics Michael Moeckel and Stefan Kehrein Quantum quenches in integrable field theories Davide Fioretto and Giuseppe Mussardo Dynamical delocalization of Majorana edge states by sweeping across a quantum critical point A Bermudez, L Amico and M A Martin-Delgado Thermometry with spin-dependent lattices D McKay and B DeMarco Near-adiabatic parameter changes in correlated systems: influence of the ramp protocol on the excitation energy Martin Eckstein and Marcus Kollar Sudden change of the thermal contact between two quantum systems J Restrepo and S Camalet Reflection of a Lieb-Liniger wave packet from the hard-wall potential D Jukić and H Buljan Probing interaction-induced ferromagnetism in optical superlattices J von Stecher, E Demler, M D Lukin and A M Rey Sudden interaction quench in the quantum sine-Gordon model Javier Sabio and Stefan Kehrein Dynamics of an inhomogeneous quantum phase transition Jacek Dziarmaga and Marek M Rams

  14. PREFACE: DICE 2012 : Spacetime Matter Quantum Mechanics - from the Planck scale to emergent phenomena

    Science.gov (United States)

    Diósi, Lajos; Elze, Hans-Thomas; Fronzoni, Leone; Halliwell, Jonathan; Prati, Enrico; Vitiello, Giuseppe; Yearsley, James

    2013-06-01

    during the conference. The papers submitted in the wake of the conference have been edited by L Diósi, H-T Elze, L Fronzoni, J J Halliwell, E Prati, G Vitiello and J Yearsley. The proceedings follow essentially the order of presentation during the conference, separating, however, invited lectures and contributed papers6. In the name of all participants, we would like to thank S Toms with her collaborators at IOP Publishing (Bristol) for friendly advice and most valuable immediate help during the editing process and, especially, for their continuing efforts to make the Journal of Physics: Conference Series available to all. Budapest, Pisa, London, Milano, Salerno, Cambridge, April 2013 Lajos Diósi, Hans-Thomas Elze, Leone Fronzoni, Jonathan Halliwell, Enrico Prati, Giuseppe Vitiello and James Yearsley 1 Decoherence and Entropy in Complex Systems ed H-T Elze Lecture Notes in Physics 633 (Berlin: Springer, 2004) 2 Proceedings of the Second International Workshop on Decoherence, Information, Complexity and Entropy - DICE 2004 ed H-T Elze Braz. Journ. Phys. 35 A & 2B (2005) pp 205-529 free access at: www.sbfisica.org.br/bjp 3 Proceedings of the Third International Workshop on Decoherence, Information, Complexity and Entropy - DICE 2006 eds H-T Elze, L Diósi and G Vitiello Journal of Physics: Conference Series 67 (2007); free access at: www.iop.org/EJ/toc/1742-6596/67/1 4 Proceedings of the Fourth International Workshop on Decoherence, Information, Complexity and Entropy - DICE 2008> eds H-T Elze, L Diósi, L Fronzoni, J J Halliwell and G Vitiello Journal of Physics: Conference Series 174 (2009); free access at: http://www.iop.org/EJ/toc/1742-6596/174/1 5 Proceedings of the Fifth International Workshop on Decoherence, Information, Complexity and Entropy - DICE 2010 eds H-T Elze, L Diósi, L Fronzoni, J J Halliwell, E Prati, G Vitiello and J Yearsley Journal of Physics: Conference Series 306 (2011); free access at: http://iopscience.iop.org/1742-6596/306/1 6 We regret that

  15. List of Participants

    Science.gov (United States)

    2007-11-01

    Physique Théorique, École Polytechnique, Palaiseau Diego Mansi Università Degli Studi di Milano Matteo Marescotti Università del Piemonte Orientale, Alessandria Alberto Mariotti Università di Milano-Bicocca Raffaele Marotta Istituto Nazionale di Fisica Nucleare, Napoli Alessio Marrani Istituto Nazionale di Fisica Nucleare and LNF, Firenze Luca Martucci Instituto de Física Teórica, Madrid and Katholieke Universiteit Leuven David Mateos University of California, Santa Barbara Andrea Mauri Università di Milano Liuba Mazzanti Università di Milano-Bicocca Patrick Meessen Instituto de Física Teórica, Universidad Autónoma de Madrid Lotta Mether Helsinki Institute of Physics Rene Meyer Max-Planck-Institut für Physik, München Giuseppe Milanesi SISSA, Trieste Cesar Miquel-Espanya Universitat de Valencia and Instituto de Física Corpuscular, Valencia Alexander Monin Institute for Theoretical and Experimental Physics (ITEP), Moscow and Moscow State University (MSU) Samuel Monnier Université de Genève Sergio Montero Instituto de Física Teórica, Madrid Nicola Mori Università di Firenze Alexander Marcel Morisse University of California, Santa Cruz Sebastian Moster Max-Planck-Institut für Physik, München Adele Nasti Queen Mary, University of London Vasilis Niarchos École Polytechnique, Palaiseau Emil Nissimov Institute for Nuclear Research and Nuclear Energy, Sofia Francesco Nitti École Polytechnique, Palaiseau Eoin O'Colgain Imperial College, London Niels Obers Niels Bohr Institute, København Rodrigo Olea Università Degli Studi di Milano Marta Orselli Niels Bohr Institute, København Enrico PajerLudwig-Maximilians-Universität, München Eran PaltiOxford University Georgios PapathanasiouBrown University, Providence, RI Angel ParedesCentre de Physique Théorique, École Polytechnique, Palaiseau Jeong-Hyuck ParkMax-Planck-Institut für Physik, München Sara PasquettiUniversità di Parma Silvia PenatiUniversità di Milano-Bicocca Igor PesandoUniversità di Torino

  16. Soil erosion and degradation in Mediterranean Type Ecosystems. The Soil Erosion and Degradation Research Group (SEDER) approach and findings

    Science.gov (United States)

    Cerdà, Artemi; Keesstra, Saskia; Pulido, Manuel; Jordán, Antonio; Novara, Agata; Giménez-Morera, Antonio; Borja, Manuel Esteban Lucas; Francisco Martínez-Murillo, Juan; Rodrigo-Comino, Jesús; Pereira, Paulo; Nadal-Romero, Estela; Taguas, Tani; Úbeda, Xavier; Brevik, Eric C.; Tarolli, Paolo; Bagarello, Vicenzo; Parras Alcantara, Luis; Muñoz-Rojas, Miriam; Oliva, Marc; di Prima, Simone

    2017-04-01

    .1016/j.earscirev.2014.07.005 Bodí, M. B., Martin, D. A., Balfour, V. N., Santín, C., Doerr, S. H., Pereira, P., . . . Mataix-Solera, J. (2014). Wildland fire ash: Production, composition and eco-hydro-geomorphic effects. Earth-Science Reviews, 130, 103-127. doi:10.1016/j.earscirev.2013.12.007 Cerdà, A., González-Pelayo, O., Giménez-Morera, A., Jordán, A., Pereira, P., Novara, A., . . . Ritsema, C. J. (2016). Use of barley straw residues to avoid high erosion and runoff rates on persimmon plantations in eastern spain under low frequency-high magnitude simulated rainfall events. Soil Research, 54(2), 154-165. doi:10.1071/SR15092 Cerdà, A., Lavee, H., Romero-Díaz, A., Hooke, J., & Montanarella, L. (2010). Preface: Soil erosion and degradation in mediterranean type ecosystems. Land Degradation and Development, 21(2), 71-74. doi:10.1002/ldr.968 Dlapa, P., Bodí, M. B., Mataix-Solera, J., Cerdà, A., & Doerr, S. H. (2015). Organic matter and wettability characteristics of wildfire ash from mediterranean conifer forests. Catena, 135, 369-376. doi:10.1016/j.catena.2014.06.018 Keesstra, S., Pereira, P., Novara, A., Brevik, E. C., Azorin-Molina, C., Parras-Alcántara, L., . . . Cerdà, A. (2016). Effects of soil management techniques on soil water erosion in apricot orchards. Science of the Total Environment, 551-552, 357-366. doi:10.1016/j.scitotenv.2016.01.182 Lucas-Borja, M. E., Hedo, J., Cerdá, A., Candel-Pérez, D., & Viñegla, B. (2016). Unravelling the importance of forest age stand and forest structure driving microbiological soil properties, enzymatic activities and soil nutrients content in mediterranean spanish black pine(pinus nigra ar. ssp. salzmannii) forest. Science of the Total Environment, 562, 145-154. doi:10.1016/j.scitotenv.2016.03.160 Novara, A., Cerdà, A., Carmelo, D., Giuseppe, L. P., Antonino, S., & Luciano, G. (2015). Effectiveness of carbon isotopic signature for estimating soil erosion and deposition rates in sicilian vineyards. Soil and

  17. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Epidemiology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Epidemiology”ABS 1. A PERFORMANCE INDICATOR FOR THE PROLONGATION OF GESTATIONAL AGE • N. LackABS 2. LATE PRETERM NEONATES AND CAUSES OF ADMISSION TO THE NICU • S. Arayici, G. Kadioglu Simsek, B. Say, E. Alyamac Dizdar, N. Uras, F.E. Canpolat, S.S. OguzABS 3. INCIDENCE AND OUTCOMES OF METABOLIC DISORDERS IN VERY PRETERM INFANTS • O. Dobush, D. Dobryanskyy, Z. Salabay, O. Detsyk, O. Novikova, Y. KuzminovABS 4. MATERNAL FACTORS INFLUENCE INFANT’S VITAMIN D STATUS • H. Hauta-alus, E. Holmlund-Suila, M. Enlund-Cerullo, J. Rosendahl, S. Valkama, O. Helve, H-M. Surcel, O. Mäkitie, S. Andersson, H. ViljakainenABS 5. THE HIGH PREVALENCE OF VITAMIN D DEFICIENCY IN A LARGE NUMBER OF PREGNANT WOMEN AND RELATED FACTORS IN ANKARA, TURKEY • G. Kadioglu Simsek, F. E. Canpolat, S. Arayici, G. Kanmaz Kutman, H.I. Yakut, Ö. Moraloğlu, B. ÖzkanABS 6. SNAPPE-II: A VALUABLE PREDICTOR OF ADVERSE OUTCOMES IN PREMATURITY • P. Costa-Reis, R. Monteiro, M. Abrantes, P. Costa, A. Graça, C. MonizABS 7. THE ASSOCIATION BETWEEN MATERNAL AND FETAL 25OHD AND INFANT SIZE AND ADIPOSITY AT BIRTH, 6 MONTHS AND 2 YEARS OF AGE • M

  18. AAS 228: Day 4

    Science.gov (United States)

    Kohler, Susanna

    2016-06-01

    Editors Note: Lastweek we were at the 228th AAS Meeting in San Diego, CA. Here is a final post aboutselectedevents on the last day of the meeting, written by authors fromastrobites.com, a grad-student collaborative project with which we recently announced a new partnership! Starting in July,keep an eye out for astrobites postsat AAS Nova in between Highlights(i.e., on Tuesdays and Thursdays).Were excited to be working together to bring you more recent astronomy research from AAS journals!Extrasolar Planets: Detection (by Leonardo dos Santos)Thursdays first session on exoplanets was about detecting these distant worlds, and the opening talk was given by Robert Siverd (Las Cumbres Observatory). He describes the NRES, a network of spectrographs that will look for exoplanets using the radial velocity method. One of the coolest aspects of this instrument is that it will feature an on the fly scheduling system that will perform observations as efficiently as possible. The spectrograph is still being tested, but a unit will be deployed at CTIO later this year.@lcogt contracted by @NASA_TESS for follow up of their candidates. #aas228 Jessie Christiansen (@aussiastronomer) June 16, 2016Measuring the depths of transits and eclipses in Spitzer has been problematic in the past, since the Spitzer instrument IRAC (InfraRed Array Camera) has a non-uniform response in its detectors pixels. But, as reported by James Ingalls (Spitzer Science Center, Caltech), observers are circumventing this issue by using what they call the staring mode (avoiding large pointing jumps) and an algorithm to pick sweet spot pixels. Moreover, the results from the IRAC Data Challenge are helping to better understand its behavior. Giuseppe Morello (University College London), on the other hand, explained how his research group gets rid of instrumental effects from IRAC using machine learning. This method removes systematics from exoplanet transit data no matter if the noise source is from an instrument or

  19. Impact landing ends SMART-1 mission to the Moon

    Science.gov (United States)

    2006-09-01

    lunar science at a time when the exploration of the Moon is once again getting the world’s interest” said Bernard Foing, ESA SMART-1 Project Scientist. “The measurements by SMART-1 call into question the theories concerning the Moon’s violent origin and evolution,” he added. The Moon may have formed from the impact of a Mars-size asteroid with the Earth 4500 million years ago. “SMART-1 has mapped large and small impact craters, studied the volcanic and tectonic processes that shaped the Moon, unveiled the mysterious poles, and investigated sites for future exploration,” Foing concluded. “ESA’s decision to extend the SMART-1 scientific mission by a further year ( it was initially planned to last only six months around the Moon) allowed the instrument scientists to extensively use a number of innovative observing modes at the Moon,” added Gerhard Schwehm, ESA’s SMART-1 Mission Manager. In addition to plain nadir observations (looking down on the ‘vertical’ line for lunar surveys), they included targeted observations, moon-spot pointing and ‘push-broom’ observations (a technique SMART-1 used to obtain colour images). “This was tough work for the mission planners, but the lunar data archive we are now building is truly impressive.” “SMART-1 has been an enormous success also from a technological point of view,” said Giuseppe Racca, ESA SMART-1 Project Manager. The major goal of the mission was to test an ion engine (solar electric propulsion) in space for the first time for interplanetary travel, and capture a spacecraft into orbit around another celestial body, in combination with gravity assist manoeuvres. SMART-1 also tested future deep-space communication techniques for spacecraft, techniques to achieve autonomous spacecraft navigation, and miniaturised scientific instruments, used for the first time around the Moon. “It is a great satisfaction to see how well the mission achieved its technological objectives, and did great lunar

  20. PREFACE: Fourth Meeting on Constrained Dynamics and Quantum Gravity

    Science.gov (United States)

    Cadoni, Mariano; Cavaglia, Marco; Nelson, Jeanette E.

    2006-04-01

    Cagliari, Italy) Roberto De Pietri (Università di Parma, Italy) Giuseppe De Risi (Università di Bari, Italy) Hans-Thomas Elze (Univ. Federal do Rio de Janeiro, Brasil) Alessandro Fabbri (Università di Bologna, Italy) Sergey Fadeev (VNIIMS, Moscow, Russia) Serena Fagnocchi (Università di Bologna, Italy) Sara Farese (Universidad de Valencia, Spain) Alessandra Feo (Università di Parma, Italy) Dario Francia (Università di Roma Tor Vergata, Italy) Francesco Fucito (Università di Roma Tor Vergata, Italy) Dmitri Fursaev (JINR, Dubna, Russia) Daniel Galehouse (University of Akron, Ohio, USA) Remo Garattini (Università di Bergamo, Italy) Florian Girelli (Perimeter Institute, Waterloo, Canada) Luca Griguolo (Università di Parma, Italy) Daniel Grumiller (Universität Leipzig, Germany) Shinichi Horata (Hayama Center of Advanced Research, Japan) Giorgio Immirzi (Università di Perugia, Italy) Roman Jackiw (MIT, Cambridge, USA) Matyas Karadi (DAMTP, University of Cambridge, UK) Mikhail Katanaev (Steklov Mathematical Institute, Moscow, Russia) Claus Kiefer (Universität Koln, Germany) John Klauder (University of Florida, Gainesville, USA) Pavel Klepac (Masaryk University, Brno, Czech Republic) Jen-Chi Lee (National Chiao-Tung University, Taiwan) Carlos Leiva (Universidad de Tarapacá, Arica, Chile) Stefano Liberati (SISSA/ISAS, Trieste, Italy) Jorma Louko (University of Nottingham, UK) Luca Lusanna (INFN, Sezione di Firenze, Italy) Roy Maartens (University of Portsmouth, UK) Fotini Markopoulou (Perimeter Institute, Waterloo, Canada) Annalisa Marzuoli (Università di Pavia, Italy) Evangelos Melas (QMW, University of London, UK) Maurizio Melis (Università di Cagliary, Italy) Vitaly Melnikov (VNIIMS, Moscow, Russia) Guillermo A. Mena Marugan (CSIC, Madrid, Spain) Pietro Menotti (Università di Pisa, Italy) Salvatore Mignemi (Università di Cagliari, Italy) Aleksandar Mikovic (Universidade Lusófona, Lisboa, Portugal) Leonardo Modesto (Université de la Mediterranée, Marseille

  1. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Circulation, O2 Transport and Haematology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Circulation, O2 Transport and Haematology”ABS 1. TRANSITIONAL CHANGES IN CEREBRAL BLOOD VOLUME OF TERM AND PRETERM INFANTS WITH AND WITHOUT RESPIRATORY SUPPORT AFTER BIRTH • B. Schwaberger, G. Pichler, A. Avian, C. Binder-Heschl, N. Baik, B. UrlesbergerABS 2. HEMATOLOGIC ABNORMALITIES IN THE FIRST 72 HOURS OF LIFE IN SMALL-FOR-GESTATIONAL-AGE PRETERM NEWBORNS • A. Matic, A. RistivojevicABS 3. THE ANTICOAGULANT ACTION OF ACTIVATED PROTEIN C IN VERY PRETERM INFANTS • E. Neary, N. McCallion, B. Kevane, K. Egan, M. Cotter, F. Ni AinleABS 4. SURVIVAL AFTER CARDIAC ARREST IN THE NEONATAL INTENSIVE CARE UNIT • E. Foglia, R. Langeveld, L. Heimall, A. Deveney, A. Ades, E. JensenABS 5. A PATENT DUCTUS ARTERIOSUS SEVERITY SCORE INCORPORATING MARKERS OF HAEMODYNAMIC SIGNIFICANCE AND LEFT VENTRICLE DIASTOLIC FUNCTION PREDICTS CHRONIC LUNG DISEASE • A.T. James, J.D. Corcoran, P. Dicker, O. Franklin, Y.N. Elsayed, J. Ting, A. Sehgal, A. Malikawi, A. Harabor, A.S. Soraisham, P.J. McNamaraABS 6. A STUDY TO VALIDATE THE DURATION OF ASSESSMENT OF BASELINE NIRS VALUES IN PRETERM BABIES WITH ECHOCARDIOGRAPHICALLY

  2. EDITORIAL The 17th Central European Workshop on Quantum Optics

    Science.gov (United States)

    Man'ko, Margarita A.

    2011-02-01

    ), held at the University of Turku, are also available (2010 Phys. Scr. T140). The 18th Central European Workshop on Quantum Optics (CEWQO11) will be held in Madrid, Spain on 30 May--3 June 2011. It will be chaired by Professor Luis Lorenzo Sanchez Soto from the Complutense University of Madrid. List of Papers The 17th Central European Workshop on Quantum Optics in St Andrews, Scotland Ulf Leonhardt and Natalia Korolkova Double self-Kerr scheme for optical Schrödinger-cat state preparation P Adam, Z Darázs, T Kiss and M Mechler Relations between scaling transformed Husimi functions, Wigner functions and symplectic tomograms describing corresponding physical states V A Andreev, D M Davidović, L D Davidović and M D Davidović Entanglement dynamics of two independent cavity-embedded quantum dots B Bellomo, G Compagno, R Lo Franco, A Ridolfo and S Savasta Dynamical stabilization of spin systems in time-dependent magnetic fields Yu V Bezvershenko, P I Holod and A Messina Entanglement dynamics of a bipartite system in squeezed vacuum reservoirs Smail Bougouffa and Awatif Hindi On Wheeler's delayed-choice Gedankenexperiment and its laboratory realization M Božić, L Vušković, M Davidović and Á S Sanz A smooth, holographically generated ring trap for the investigation of superfluidity in ultracold atoms Graham D Bruce, James Mayoh, Giuseppe Smirne, Lara Torralbo-Campo and Donatella Cassettari Parametric amplification of the classical field in cavities with photoexcited semiconductors V V Dodonov Mutually unbiased bases: tomography of spin states and the star-product scheme S N Filippov and V I Man'ko Quantum trajectory model for photon detectors and optoelectronic devices Teppo Häyrynen, Jani Oksanen and Jukka Tulkki Entanglement in two-mode continuous variable open quantum systems Aurelian Isar A classical field comeback? The classical field viewpoint on triparticle entanglement Andrei Khrennikov Experimental investigation of the enhancement factor and the cross

  3. SMART-1: the first spacecraft of the future

    Science.gov (United States)

    2003-09-01

    This is the first of a series of missions designed to test key technologies for future spacecraft —SMART stands for 'Small Missions for Advanced Research and Technology'. In the case of SMART-1, the two main new technologies to be tested are a new 'solar-electric propulsion' system and miniaturised spacecraft and instrumentation. Together, these technologies make up a spacecraft with revolutionary qualities: smaller, lighter, capable of carrying more scientific instruments, greater fuel efficiency. All of which also considerably reduces the cost of the mission. So, the idea behind SMART-1 is to pioneer a futuristic philosophy, the motto of which could be: 'more science for less money'. Even though it is the first of a kind, SMART-1 has been developed in less than four years, and at about a fifth of the cost of a major science mission for ESA: only 110 million euros. That includes the launch, the operations and a dozen scientific experiments. This was achieved partly by using new management methods — such as working with smaller teams both within ESA and in the industry — and partly because of some of the new features inherent in SMART-1, such as the miniaturisation and novel design. Giuseppe Racca, SMART-1 Project Manager, explains: "What has been our trick? First, a short development period in itself means less money. But also, with its small size — which was a requirement of the mission because we are testing miniaturised hardware — the spacecraft is able to 'share' a commercial Ariane flight with two other passengers. Besides, since we were not constrained by any existing design or heritage, we could be more innovative and elegant in our architecture. For example, the new SMART-1 electrical architecture has enabled us to simplify the system tests considerably." SMART-1 could almost be a toy spacecraft — it weighs only 367 kilograms and fits into a cube just one metre across (the solar panel wings extend about 14 metres) — although one able to

  4. First Announcement and Call for Papers SECOND INTERNATIONAL SYMPOSIUM ON FLOOD DEFENCE

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    . Italy Salas, J.D. USA Dong, Zheren China Singh, R.B. India Evans, Edward UK Soroosh, Sorooshian USA Falconer, R.A. UK Takahashi,T. Japan Ikeda, Syunsuke Japan Tamai, N. Japan Jozan, Krisztina Hungary Tan, Ying China Knight, D.W. UK Todini, Ezio Italy Koch, M. Germany Toensmann, F. Germany Koffman, H.M. USA Tung, Y.K. HK Lee, Joseph.H.W. HK White, W.R. UK Onorati, Giuseppe Italy Wood, Ian New Zealand Overbeek, H.J. Netherlands van Stokkom, H. Netherland Patel, V.C. USA Yen, B.C. USA CONFERENCE STRUCTURE Keynote lectures will be given in plenary sessions. Invited lectures and papers focusing on thematic complexes will be presented in parallel sessions in the first three days (the fourth day is scheduled for a one-day city tour). Papers may also be presented in poster sessions. The conference will offer facilities, including overhead, slide and beamer (computer projector) for presentations. Submitted abstracts will be peer reviewed and papers will be invited on the basis of the abstracts. The papers themselves will also be reviewed to ensure an appropriate technical and English standard for the meeting. The proceedings of the conference will be published in book form and will be available to delegates at the time of registration. A CD of the electronic version of the proceedings will be presented to the full-registered participants. After the conference the proceedings will be widely distributed by the international book trade. A one-day city tour and two conference banquets will be arranged for the delegates and their companions,which are included in the registration fee.REGISTRATION FEE The registration fee for participation in the conference will be US $500. A discount of 10% applies for members of IAHR and the sponsor organizations (US$450) or early payment before Aug. 1, 2002. The registration fee will cover the proceedings (book and CD), publication of papers, conference banquets, city tour on the last conference day, daily lunches and coffee & tea breaks. For

  5. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Nutrition and gastroenterology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Nutrition and gastroenterology”ABS 1. NEONATAL ANTIBIOTICS IN PRETERM INFANTS AND RISK OF ALLERGIC DISEASES LATER IN LIFE • E. Westerbeek, A. van Zwol, L. Carstens, R. van ElburgABS 2. FRENOTOMY FOR TONGUE-TIE IN NEWBORN INFANTS: A SYSTEMATIC REVIEW • J.E. O’Shea, J.P. Foster, S.E. Jacobs, C.P.F. O’Donnell, D.A. Todd, P.G. DavisABS 3. EARLY FORMULA MAY HELP SUPPORT LONG-TERM BREASTFEEDING • Z. Stranak, J. Kolarova, M. CernaABS 4. COMPARISON OF DRY BLOOD SPOT AMINO ACID PROFILES BETWEEN PRETERM INFANTS AT TERM POSTMENSTRUAL AGE AND HEALTHY TERM NEWBORNS • C. Balcells, M. Izquierdo-Renau, M. Molero, C. Sierra, R. Artuch, I. Iglesias-PlatasABS 5. VARIABILITY IN BONE MARKERS PROFILE OF NEWBORNS AND THEIR MOTHERS AFTER DHA SUPPLEMENTATION IN PREGNANCY • L. Serrano López, M. Peña Caballero, E. Martín Álvarez, J. Diaz Castro, N. Najarabille, J.J. Ochoa, J.A. Hurtado SuazoABS 6. A SYNBIOTIC MIXTURE OF scGOS/lcFOS AND BIFIDOBACTERIUM BREVE M-16V IS ABLE TO RESTORE THE DELAYED COLONIZATION OF BIFIDOBACTERIA SPP. IN C-SECTION DELIVERED INFANTS • M.C. Chua, C. Chew, A. Goh, W.C. Chiang, R. Rao1, C. Lay, K

  6. List of Participants

    Science.gov (United States)

    2008-11-01

    cole Polytechnique, Palaiseau and University of Crete Denis KleversPhysikalisches Institut, Universität Bonn Paul Koerber Max-Planck-Institut für Physik, München Simon Koers Max-Planck-Institut für Physik, München Karl KollerLudwig-Maximilians-Universität, München Peter Koroteev Institute for Theoretical and Experimental Physics (ITEP), Moscow and Max-Planck-Institut für Gravitationsphysik (AEI), Potsdam Alexey KoshelevVrije Universiteit, Brussel Costas KounnasÉcole Normale Supérieure, Paris Daniel KreflCERN, Geneva Charlotte KristjansenNiels Bohr Institute, København Finn LarsenCERN, Geneva and University of Michigan Arnaud Le DiffonÉcole Normale Supérieure, Lyon Michael LennekCentre de Physique Théorique, École Polytechnique, Palaiseau Alberto Lerda Università del Piemonte Orientale, Alessandria Andreas LiberisUniversity of Patras Maria A Lledo Universidad de Valencia Oscar Loaiza-Brito CINVESTAV, Mexico Florian Loebbert Max-Planck-Institut für Gravitationsphysik (AEI), Potsdam Yolanda Lozano University of Oviedo Dieter Luest Ludwig-Maximilians-Universität, München Tomasz Łukowski Jagiellonian University, Krakow Diego Mansi University of Crete Alberto Mariotti Università di Milano-Bicocca Raffaele Marotta Istituto Nazionale di Fisica Nucleare, Napoli Alessio Marrani Istituto Nazionale di Fisica Nucleare and LNF, Firenze Andrea Mauri University of Crete Liuba Mazzanti École Polytechnique, Palaiseau Sean McReynoldsUniversità di Milano-Bicocca AKM Moinul Haque Meaze Chittagong University Patrick Meessen Instituto de Física Teórica, Universidad Autónoma de Madrid Carlo MeneghelliUniversità di Parma and Albert-Einstein-Institut, Golm Lotta Mether University of Helsinki and CERN, Geneva René Meyer Max-Planck-Institut für Physik, München Georgios MichalogiorgakisCenter de Physique Théorique, École Polytechnique, Palaiseau Giuseppe Milanesi Eidgenössische Technische Hochschule (ETH), Zürich Samuel Monnier Université de Genève Wolfgang Mueck

  7. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Other”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Other”ABS 1. TELEMEDICINE IN NEONATAL HOMECARE • K.G. Holm, A. Brodsgaard, G. Zachariassen, J. ClemensenABS 2. ACCEPTABILITY OF PARENT REPORT QUESTIONNAIRES FOR ROUTINE FOLLOW-UP IN LATE/MODERATELY PRETERM INFANTS • N. Armstrong, S. Johnson, E.M. BoyleABS 3. INTERNATIONAL CARE PRACTICES AROUND AN INFANT’S DEATH IN THE NICU; A SURVEY STUDY • C.M.C. van den Berg, K. Alferink, J.M. Latour, N. Valkenburg, M. van DijkABS 4. ANXIETY AND DEPRESSION OVER TIME, IN MOTHERS OF VERY PRETERM BORN CHILDREN • M. Jeukens-Visser, M. Husson, D. Meijssen, M. Flierman, P. van Schie, K. Koldewijn, A. Wassenaer-van LeemhuisABS 5. LONGITUDINAL CHANGE OF HEALTH-RELATED QUALITY OF LIFE EXPERIENCED OVER TIME BY MOTHER WITH LATE PRETERM INFANT • L.Y. Tsai, S.C. Mu, Y.L. Chen, Y.L. Guo, P.C. ChenABS 6. RELATIONSHIP BETWEEN ANXIETY LEVELS AND CLINICAL PRACTICE SKILLS AMONG STUDENTS OF PEDIATRIC NURSING LECTURE • A.S. Kurt, F.T. Arslan, S. Özkan, R. Çelen, D.A. ÇakırABS 7. ACCURACY OF SMARTPHONES FOR REVIEWING TRANSMITTED IMAGES OF NEONATAL X-RAYS • T. Vasko, M. Westberg, J.A. Dawson, L.S. Owen, M. Thio, R. Bhatia, S. Donath

  8. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pulmonology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pulmonology”ABS 1. URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN AS A MARKER OF BRONCHOPULMONARY DYSPLASIA AND RETINOPATHY OF PREMATURITY IN PRETERM NEONATES • H. Ergin, T. Atilgan, M. Dogan, O.M.A. Ozdemir, C. YeniseyABS 2. LUNG COMPLIANCE AND LUNG ULTRASOUND DURING POSTNATAL ADAPTATION IN HEALTHY NEWBORN INFANTS • L. Süvari, L. Martelius, C. Janér, A. Kaskinen, O. Pitkänen, T. Kirjavainen, O. Helve, S. AnderssonABS 3. PRE-DISCHARGE RESPIRATORY OUTCOMES IN SMALL-FOR-GESTATIONAL-AGE AND APPROPRIATE-FOR-GESTATIONAL-AGE VERY PRETERM INFANTS • A. Matic, A. RistivojevicABS 4. THE EFFECT OF CHANGING OXYGEN SATURATION TARGET RANGE ON COMPLIANCE IN OXYGEN SATURATION TARGETING IN THE NEONATAL INTENSIVE CARE UNIT • H.A. van Zanten, S. Pauws, E.C.H. Beks, B.J. Stenson, E. Lopriore, A.B. te PasABS 5. BINASAL PRONG VERSUS NASAL MASK FOR APPLYING CPAP TO PRETERM INFANTS: RANDOMIZED CONTROLLED TRIAL • B. Say, G. Kanmaz, S.S. OguzABS 6. TRAINING AND RAISING AWARENESS IMPROVES COMPLIANCE IN OXYGEN SATURATION TARGETING IN THE NEONATAL INTENSIVE CARE UNIT • H.A. van Zanten, S. Pauws, E.C.H. Beks, B.J. Stenson, E

  9. 6th International Symposium on Molecular Allergology (ISMA

    Directory of Open Access Journals (Sweden)

    Christiane Hilger

    2016-10-01

    -patient quantification of allergen-specific IgE Petra Zavadakova, Aurélie Buchwalder, Fabien Rebeaud, Iwan Märki Symposium 4: Relevance of molecular diagnostics for intervention and treatment O7 Longitudinal analysis of Bet v 1-specific epitope repertoires during birch pollen immunotherapy Barbara Gepp, Nina Lengger, Christian Möbs, Wolfgang Pfützner, Christian Radauer, Barbara Bohle O8 A natural CCD-free tool: is polistes sp. venom suitable for polybia paulista diagnosis and therapy? Karine Marafigo De Amicis, Alexandra Sayuri Watanabe, Clovis Eduardo Galvao, Daniele Danella Figo, Jose Roberto Aparecido Santos-Pinto, Mario Sergio Palma, Fabio Fernandes Morato Castro, Jorge Kalil, Fatima Ferreira, Gabriele Gadermaier, Keity Souza Santos Symposium 5: The advent of molecular allergology in epidemiology O9 Peanut oleosins: from identification to diagnostic testing Christian Schwager, Skadi Kull, Frauke Schocker, Jochen Behrends, Wolf-Meinhard Becker, Uta Jappe O10 Endotypes of oral allergy syndrome in childhood: a molecular diagnostic approach Carla Mastrorilli, Salvatore Tripodi, Carlo Caffarelli, Riccardo Asero, Arianna Dondi, Giampaolo Ricci, Carlotta Povesi Dascola, Elisabetta Calamelli, Andrea Di Rienzo Businco, Annamaria Bianchi, Tullio Frediani, Carmen Verga, Iride Dello Iacono, Diego Peroni, Giuseppe Pingitore, Roberto Bernardini, Paolo Maria Matricardi Symposium 6: Molecular AIT: which approaches will make it to market? O11 Mbc4: an innovative molecule to tackle birch pollen and concomitant food allergies Heidi Hofer, Claudia Asam, Michael Hauser, Peter Briza, Martin Himly, Christof Ebner, Fatima Ferreira O12 Challenges and solutions associated with the production of recombinant Bet v 1 allergen as a therapeutic protein Emmanuel Nony, Maxime Le Mignon, Pierrick Lemoine, Karine Jain, Kathy Abiteboul, Monica Arvidsson, Sabina Rak, Philippe Moingeon Clinical Cases: Breakthroughs and headaches from CRD: interactive session CC1 Anaphylaxis caused by lipid transfer proteins: a

  10. Session 2

    Science.gov (United States)

    2014-01-01

    3.1 Systems Analysis of Mitochondrial Pathogenesis Vamsi Mootha Harvard Medical School, Boston, MA, USA Mitochondrial dysfunction underlies a wide range of human diseases, including rare, monogenic diseases, common diseases, as well as the aging process itself. How cells cope with mitochondrial dysfunction is not fully understood. We performed complementary RNA, protein, and metabolite profiling of a cellular model of inducible mitochondrial dysfunction. In this talk I will describe these profiling results, as well as an adaptive pathway that they point to. The study provides insight into the pathogenesis of mitochondrial disorders 3.2 PTMomics – Towards Comprehensive Quantitative Analysis of Multiple PTMs from Biological Material Martin R. Larsen,1, Honggang Huang1, Cristina Alarcón2, Alistair V.G. Edwards1, Christopher Rhodes2, Giuseppe Palmisano3 1University of Southern Denmark, Odense, Denmark; 2University of Chicago, IL, USA; 3University of Sao Paulo, Brazil Post- or co-translational modifications (PTMs) of proteins refer to the reversible or irreversible addition of chemical modifying groups to proteins after or during their synthesis. Proteins have often multiple PTMs decorating the primary amino acid sequence and often these affect each other to produce a given function or activity of a protein. PTMomics can be defined as the global study of PTMs and is a relatively new research area aiming at understanding the function and consequences of PTMs of proteins in a cell. The success of PTMomics relies on the ability to efficiently purify the relevant PTMs and subsequently identify and characterize the nature and function of the PTM using for example mass spectrometric analysis. Previously, we have developed a number of successful methods for enrichment of phosphorylated peptides (1–3), sialylated N-linked glycopeptides (4, 5) and O-GLcNAcylated peptides (6) and we have combined some of these methods into strategies for simultaneous enrichment of several

  11. Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012).

    Science.gov (United States)

    Foffi, G; Pastore, A; Piazza, F; Temussi, P A

    2013-08-02

    inspiring talk, Clifford Brangwynne, from Princeton University (USA), drew attention to very important objects, namely Ribonucleoprotein (RNP) bodies. These are non-membrane-bound macromolecular assemblies that form from the dynamic interactions of RNA and proteins. The assembly of RNP bodies may sensitively depend on the biophysical features of the surrounding cytoplasm, including the degree of crowding, transport coefficients and mechanical properties. This dependency may have important implications for the RNA processing reactions involved in fundamental biological processes such as developmental cell growth. Remarkably, Brangwynne showed how RNPs behave in the cell as liquid droplets, pointing to a possible entirely new means that the cell could use to control and fine-tune its internal processes, in fact, more than that, a completely unexplored, new state of organization of living matter, and a functional one. Giuseppe Zaccai, from Institut Laue Langevin, Grenoble (France), showed that protein dynamics is more sensitive than structure to environmental factors such as crowding, solvent, temperature or pressure. Furthermore, he convincingly explained how neutron scattering provides unique experimental data to underpin MD calculations in this context. Following up on environment-induced modulations of protein functional dynamics, Ruth Nussinov, from Tel Aviv University (Israel), addressed the important problem of whether cellular signals can travel long distances in a crowded environment. She proposed a model based on the evolution of at least three properties: a modular functional organization of the cellular network, sequences in some key regions of proteins, such as linkers or loops, and compact interactions between proteins, possibly favoured by a crowded environment. The workshop ended on a keynote lecture by Jean-Marie Lehn, from the Université de Strasbourg (France). Lehn, 1987 Nobel Laureate in chemistry, offered a 'supramolecular view' of the field of molecular

  12. Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012)

    Science.gov (United States)

    Foffi, G.; Pastore, A.; Piazza, F.; Temussi, P. A.

    2013-08-01

    Princeton University (USA), drew attention to very important objects, namely Ribonucleoprotein (RNP) bodies. These are non-membrane-bound macromolecular assemblies that form from the dynamic interactions of RNA and proteins. The assembly of RNP bodies may sensitively depend on the biophysical features of the surrounding cytoplasm, including the degree of crowding, transport coefficients and mechanical properties. This dependency may have important implications for the RNA processing reactions involved in fundamental biological processes such as developmental cell growth. Remarkably, Brangwynne showed how RNPs behave in the cell as liquid droplets, pointing to a possible entirely new means that the cell could use to control and fine-tune its internal processes, in fact, more than that, a completely unexplored, new state of organization of living matter, and a functional one. Giuseppe Zaccai, from Institut Laue Langevin, Grenoble (France), showed that protein dynamics is more sensitive than structure to environmental factors such as crowding, solvent, temperature or pressure. Furthermore, he convincingly explained how neutron scattering provides unique experimental data to underpin MD calculations in this context. Following up on environment-induced modulations of protein functional dynamics, Ruth Nussinov, from Tel Aviv University (Israel), addressed the important problem of whether cellular signals can travel long distances in a crowded environment. She proposed a model based on the evolution of at least three properties: a modular functional organization of the cellular network, sequences in some key regions of proteins, such as linkers or loops, and compact interactions between proteins, possibly favoured by a crowded environment. The workshop ended on a keynote lecture by Jean-Marie Lehn, from the Université de Strasbourg (France). Lehn, 1987 Nobel Laureate in chemistry, offered a 'supramolecular view' of the field of molecular interactions. Supramolecular chemistry