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Sample records for hept derivatives optimization

  1. QSAR study for anti-HIV-1 activities of HEPT derivatives using MLR and PLS

    Directory of Open Access Journals (Sweden)

    Ivan Daniela

    2013-01-01

    Full Text Available A QSAR study using Multiple Linear Regression (MLR and a Partial Least Squares (PLS methodology was performed for a series of 127 derivatives of 1-(2-hydroxy-ethoxymethyl]-6-(phenylthio-timine (HEPT, a potent inhibitor of the of the human immunodeficiency virus type 1, HIV-1 reverse transcriptase (RT. To explore the relationship between a pool of HEPT derivative descriptors (as independent variables and anti-HIV-1 activity expressed as log (1/EC50, as dependent variable MLR and PLS methods have been employed. Using Dragon descriptors, the present study aims to develop a predictive and robust QSAR model for predicting anti-HIV activity of the HEPT derivatives for better understanding the molecular features of these compounds important for their biological activity. According to the squared correlation coefficients, which had values between 0.826 and 0.809 for the MLR and PLS methods, the results demonstrate almost identical qualities and good predictive ability for both MLR and PLS models. After dividing the dataset into training and test sets, the model predictability was tested by several parameters, including the Golbraikh-Tropsha external criteria and the goodness of fit tested with the Y-randomization test. [Acknowledgements. This project was financially supported by Project 1.1 and 1.2 of the Institute of Chemistry of the Romanian Academy. STATISTICA, MobyDigs and SIMCA-P+ acquisition was funded by Ministerul Educatiei, Cercetarii si Tineretului - Autoritatea Nationala pentru Cercetare Stiintifica (MedC-ANCS, contract grant number: 71GR/2006

  2. Unsupervised selection of informative descriptors in QSAR study of anti-HIV activities of HEPT derivatives

    DEFF Research Database (Denmark)

    Bagheri, Saeed; Omidikia, Nematollah; Kompany-Zareh, Mohsen

    2013-01-01

    selection is unsupervised indeed. Besides, scores that are the linear combination of the data variables are set as dependent variables (artificial dependent variables). It includes 107 derivatives of HEPT molecule, characterized by 160 descriptors encoding the steric, hydrophobic, electronic and structural......With the increasing ease of measuring and calculating multiple descriptors per molecule in quantitative structure-activity relationship, the importance of variable selection for data reduction and improving interpretability is gaining importance. While variable selection has been extensively...... studied in the context of supervised learning, in this paper, an unsupervised learning method is proposed for variable selection and its performance is assessed using a typical QSAR data set. Whereas there is no real dependent variable in the proposed variable selection algorithm, applied variable...

  3. Swern Oxidation of Bicyclo[2.2.1]hept-5-ene-2,3-diol and Its Pyrazine-fused Derivatives: An Improved Synthesis of Bicyclo[2.2.1]hept-5-ene-2,3-dione and An Unexpected Ring-Opening Reaction

    Directory of Open Access Journals (Sweden)

    Sayuri Kobayashi

    2000-09-01

    Full Text Available An improved synthesis of bicyclo[2.2.1]hept-5-ene-2,3-dione by Swern oxidation of bicyclo[2.2.1]hept-5-ene-2,3-diol, and an unexpected ring-opening reaction by the Swern oxidation of pyrazine-fused congeners are described.

  4. Stereochemistry of the epoxidation of bicyclo[2.2.1]hept-2-ene and its 7-syn-substituted derivatives. A DFT study

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    Sergiy I. Okovytyy

    2014-12-01

    Full Text Available The stereochemical aspects of epoxidation of norbornene and its 7-syn-substituted derivatives by performic acid were investigated. Geometry and thermodynamic parameters of transition states and prereactive complexes were computed at the UBHandHLYP/6-31G(d level of theory. It is shown that the transition states have a pronounced biradical character and a nearly coplanar orientation of the C=C bond and the molecule of performic acid. Transition state analysis revealed that, in the case of the syn-7-hydroxy derivative, the preference for the exo-approach of the oxidant can be explained by the stabilization of transition state with hydrogen bonding. In contrast, a chlorine atom or a methyl group at the 7-syn position facilitated the formation of endo-epoxides due to steric repulsion between the substituent and the oxidant.

  5. George Henry Hepting: Pioneer Leader in Forest Pathology

    Science.gov (United States)

    Ellis B. Cowling; Arthur Kelman; Harry R. Powers

    1999-01-01

    George Henry Hepting grew up in the city environment of Brooklyn, but early in his life developed a deep love and scientific interest in forestry. He became America's most skilled scientist in the theory and practice of forest pathology. He studied how long-lived forest trees, unlike most plants, cope with the long-term changes in their biological, physical, and...

  6. A topological derivative method for topology optimization

    DEFF Research Database (Denmark)

    Norato, J.; Bendsøe, Martin P.; Haber, RB

    2007-01-01

    We propose a fictitious domain method for topology optimization in which a level set of the topological derivative field for the cost function identifies the boundary of the optimal design. We describe a fixed-point iteration scheme that implements this optimality criterion subject to a volumetric...

  7. Numerical derivative techniques for trajectory optimization

    Science.gov (United States)

    Hallman, Wayne P.

    1990-01-01

    The adoption of robust numerical optimization techniques in trajectory simulation programs has resulted in powerful design and analysis tools. These trajectory simulation/optimization programs are widely used, and a representative list includes the GTS system, the POST program, and newer collocation methods such as OTIS and FONPAC. All of these programs rely on optimization algorithms which require objective function and constraint gradient data during the iteration process. However, most trajectory optimization problems lack simple analytical expressions for these derivatives. In the general case a function evaluation involves integrating aerodynamic, propulsive, and gravity forces over multiple trajectory phases with complex control models. With the newer collocation methods, the integration is replaced by defect constraints and cubic approximations for the state. While analytic gradient expressions can sometimes be derived for trajectory optimization problems, the derivation is cumbersome, time consuming, and prone to mistakes. Fortunately, an alternate method exists for the gradient evaluation, namely finite difference approximations. In this paper some finite difference gradient techniques developed for use with the GTS system are presented. These techniques include methods for computing first and second partial derivatives of single and multiple sets of functions. A key feature of these methods is an error control mechanism which automatically adjusts the perturbation size to obtain accurate derivative values.

  8. Derivative-free and blackbox optimization

    CERN Document Server

    Audet, Charles

    2017-01-01

    This book is designed as a textbook, suitable for self-learning or for teaching an upper-year university course on derivative-free and blackbox optimization.  The book is split into 5 parts and is designed to be modular; any individual part depends only on the material in Part I.  Part I of the book discusses what is meant by Derivative-Free and Blackbox Optimization, provides background material, and early basics while Part II focuses on heuristic methods (Genetic Algorithms and Nelder-Mead).  Part III presents direct search methods (Generalized Pattern Search and Mesh Adaptive Direct Search) and Part IV focuses on model-based methods (Simplex Gradient and Trust Region).  Part V discusses dealing with constraints, using surrogates, and bi-objective optimization. End of chapter exercises are included throughout as well as 15 end of chapter projects and over 40 figures.  Benchmarking techniques are also presented in the appendix.

  9. Optimization of Turbine Engine Cycle Analysis with Analytic Derivatives

    Science.gov (United States)

    Hearn, Tristan; Hendricks, Eric; Chin, Jeffrey; Gray, Justin; Moore, Kenneth T.

    2016-01-01

    A new engine cycle analysis tool, called Pycycle, was recently built using the OpenMDAO framework. This tool uses equilibrium chemistry based thermodynamics, and provides analytic derivatives. This allows for stable and efficient use of gradient-based optimization and sensitivity analysis methods on engine cycle models, without requiring the use of finite difference derivative approximation methods. To demonstrate this, a gradient-based design optimization was performed on a multi-point turbofan engine model. Results demonstrate very favorable performance compared to an optimization of an identical model using finite-difference approximated derivatives.

  10. Genetic Optimization Using Derivatives: The rgenoud Package for R

    Directory of Open Access Journals (Sweden)

    Walter R. Mebane Jr.

    2011-08-01

    Full Text Available genoud is an R function that combines evolutionary algorithm methods with a derivative-based (quasi-Newton method to solve difficult optimization problems. genoud may also be used for optimization problems for which derivatives do not exist. genoud solves problems that are nonlinear or perhaps even discontinuous in the parameters of the function to be optimized. When the function to be optimized (for example, a log-likelihood is nonlinear in the model's parameters, the function will generally not be globally concave and may have irregularities such as saddlepoints or discontinuities. Optimization methods that rely on derivatives of the objective function may be unable to find any optimum at all. Multiple local optima may exist, so that there is no guarantee that a derivative-based method will converge to the global optimum. On the other hand, algorithms that do not use derivative information (such as pure genetic algorithms are for many problems needlessly poor at local hill climbing. Most statistical problems are regular in a neighborhood of the solution. Therefore, for some portion of the search space, derivative information is useful. The function supports parallel processing on multiple CPUs on a single machine or a cluster of computers.

  11. Synthesis of 1-Methyl-3-oxo-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic Acid Methyl Ester

    Directory of Open Access Journals (Sweden)

    Gil Valdo José da Silva

    2005-11-01

    Full Text Available A simple and efficient method for the preparation of 1-methyl-3-oxo-7- oxabicyclo[2.2.1]hept-5-en-2-carboxylic acid methyl ester (1 is described. The first step is a highly regioselective Diels-Alder reaction between 2-methylfuran and methyl-3-bromo- propiolate. A remarkably difficult ketal hydrolysis reaction was effected by treatment with HCl, a simple reagent that was shown to be more efficient, in this case, than commonly used more elaborate methods.

  12. Optimal economic order quantity for buyer-distributor-vendor supply chain with backlogging derived without derivatives

    Science.gov (United States)

    Teng, Jinn-Tsair; Cárdenas-Barrón, Leopoldo Eduardo; Lou, Kuo-Ren; Wee, Hui Ming

    2013-05-01

    In this article, we first complement an inappropriate mathematical error on the total cost in the previously published paper by Chung and Wee [2007, 'Optimal the Economic Lot Size of a Three-stage Supply Chain With Backlogging Derived Without Derivatives', European Journal of Operational Research, 183, 933-943] related to buyer-distributor-vendor three-stage supply chain with backlogging derived without derivatives. Then, an arithmetic-geometric inequality method is proposed not only to simplify the algebraic method of completing prefect squares, but also to complement their shortcomings. In addition, we provide a closed-form solution to integral number of deliveries for the distributor and the vendor without using complex derivatives. Furthermore, our method can solve many cases in which their method cannot, because they did not consider that a squared root of a negative number does not exist. Finally, we use some numerical examples to show that our proposed optimal solution is cheaper to operate than theirs.

  13. Evolutionary optimization of network reconstruction from derivative-variable correlations

    Science.gov (United States)

    Leguia, Marc G.; Andrzejak, Ralph G.; Levnajić, Zoran

    2017-08-01

    Topologies of real-world complex networks are rarely accessible, but can often be reconstructed from experimentally obtained time series via suitable network reconstruction methods. Extending our earlier work on methods based on statistics of derivative-variable correlations, we here present a new method built on integrating an evolutionary optimization algorithm into the derivative-variable correlation method. Results obtained from our modification of the method in general outperform the original results, demonstrating the suitability of evolutionary optimization logic in network reconstruction problems. We show the method’s usefulness in realistic scenarios where the reconstruction precision can be limited by the nature of the time series. We also discuss important limitations coming from various dynamical regimes that time series can belong to.

  14. Synthesis of 6-Substituted 2-Pyrones Starting from Renewable Resources: Total Synthesis of Sibirinone, (E)-6-(Pent-1-en-1-yl)-2H-pyran-2-one, and (E)-6-(Hept-1-en-1-yl)-2H-pyran-2-one.

    Science.gov (United States)

    Dobler, Daniel; Reiser, Oliver

    2016-11-04

    An atom-economic reaction sequence to 6-substituted 2-pyrones was developed starting from furfuryl alcohol, a renewable resource made from bran or bagasse, and aldehydes, utilizing a thermal rearrangement of cyclopentadienone epoxides as key step. Derivatives bearing a hydroxyalkyl side chain could be enzymatically resolved, providing access to enantiomerically pure 2-pyrones, or converted to alkenyl-substituted 2-pyrones such as naturally occurring sibirinone, (E)-6-(pent-1-en-1-yl)-2H-pyran-2-one, and (E)-6-(hept-1-en-1-yl)-2H-pyran-2-one.

  15. Statistical effects in the thermal deazetization reaction of 2,3-diazabicyclo(2.2.1)hept-2-ene

    Science.gov (United States)

    Sorescu, Dan C.; Thompson, Donald L.; Raff, Lionel M.

    1995-10-01

    The deazetization reaction of 2,3-diazabicyclo(2.2.1)hept-2-ene-exo, exo-5,6-d2 is investigated using Monte Carlo classical variational transition-state theory, implemented by the efficient microcanonical sampling procedure. Comparison is made with the results of trajectory calculations performed on the same global potential-energy surface. The microcanonical reaction rates have been determined for both reaction channels, i.e., the stepwise and concerted cleavage of the two C-N bonds of the reactant. The results demonstrate that the thermal decomposition of 2,3-diazabicyclo (2.2.1)hept-2-ene-exo,exo-5,6-d2 is well described by statistical theories that assume equal weighting for all energetically accessible phase-space points. It is found that the rate coefficients of the statistical calculations are close upper bounds of the rates determined in trajectory calculations. Previously reported classical trajectory simulations have shown that the distribution of internal energy in the reactant configuration, at the transition state and beyond is very nearly microcanonical for the range of excitation energies analyzed (60-175 kcal/mol). Under such conditions, the agreement obtained between the present statistically computed rate coefficients and those extracted from the trajectory results is not surprising. It is suggested that nonstatistical post-transition-state events account for the nonunity ratio of the exo/endo reaction products observed experimentally. These events are not considered in the present statistical theories of the reaction rates.

  16. Optimization process of tribenzoine production as a glycerol derived product

    Science.gov (United States)

    Widayat, Abdurrakhman, Rifianto, Y.; Abdullah, Hadiyanto, Samsudin, Asep M.; Annisa, A. N.

    2015-12-01

    Tribenzoin is a derived product from glycerol that can produce from glycerol conversion via esterification process. The product can be used in the food industry, cosmetics industry, polymer industry and also can be used to improve the properties of adhesive materials and water resistance in the ink printer.In the other hand, it advantages is environmentally friendly andrenewable because it is not derived from petroleum. This paper discusses the effect of temperature and catalyst concentration for tribenzoin production. For the responses, yield and product composition were observed. Results showed that the highest yield achieved at optimal variable data processed using Central Composite Design (CCD) which is 63.64 temperature (°C), mole ratio of benzoic acidto glycerol is 3.644:1, and catalyst concentration 6.25% (wt% glycerol). Yield products produced 58.71%. FTIR analysis results showed that the samples contained the results of IR spectra wavelength 1761 cm-1 in the fingerprint region and 3165 cm-1 frequency region group. The existence of these two adjustments that fixed in the area is strong evidence that the compound is tribenzoin.

  17. Molecular dynamics studies of the thermal decomposition of 2,3-diazabicyclo(2.2.1)hept-2-ene

    Science.gov (United States)

    Sorescu, Dan C.; Thompson, Donald L.; Raff, Lionel M.

    1995-05-01

    The reaction dynamics of the thermal gas-phase decomposition of 2,3-diazabicyclo (2.2.1)hept-2-ene-exo, exo-5,6-d2 have been investigated using classical trajectory methods on a semiempirical potential-energy surface. The global potential is written as a superposition of different reaction channel potentials containing bond stretching, bending and torsional terms, connected by parametrized switching functions. Reaction channels for stepwise and concerted cleavage of the two C-N bonds of the reactant have both been considered in construction of the potential. The geometries of 2,3-diazabicyclo(2.2.1)hept-2-ene, the diazenyl biradical and of the transition state corresponding to breaking of the remaining C-N bond of diazenyl biradical have been determined at the second order Möller-Plesset perturbation theory (MP2/6-31G*) and at Hartree-Fock (HF/6-31G*) levels, respectively. The bond dissociation energies have been estimated using the available thermochemical data and previously reported results for bicyclo(2.1.0)pentane [J. Chem. Phys. 101, 3729 (1994)]. The equilibrium geometries predicted by the semiempirical potential for reactants and products, the barrier height for thermal nitrogen extrusion from 2,3-diazabicyclo(2.2.1)hept-2-ene and the fundamental vibrational frequencies are in good to excellent agreement with the measured or ab initio calculated values. Using a projection method of the instantaneous Cartesian velocities onto the normal mode vectors and classical trajectory calculations, the dissociation dynamics of 2,3-diazabicyclo(2.2.1)hept-2-ene-exo, exo-5,6-d2 are investigated at several excitation energies in the range 60-175 kcal/mol. The results show the following: (1) The thermal reaction takes place with a preference for inversion of configuration in the reaction products, the exo-labeled bicyclo(2.1.0) pentane being the major product. The exo/endo ratio of bicyclo(2.1.0) pentane isomers is found to vary between 1.8-2.2 for the energy range

  18. First example of stepwise, zwitterionic mechanism for bicyclo[2.2.1]hept-5-ene (norbornene) formation process catalyzed by the 1-butyl-3-methylimidazolium cations.

    Science.gov (United States)

    Jasiński, Radomir

    B3LYP/6-31++G(d) calculations indicated that the reaction of (2 E )-3-phenyl-2-nitroprop-2-enenitrile with cyclopentadiene catalyzed by cations of 1,3-dialkylimidazolium ionic liquid shall not take place according to the classical scheme of one-step [2+4] Diels-Alder cycloaddition. Along the path finally leading to bicyclo[2.2.1]hept-5-ene (norbornene) with a nitro group in endo orientation, the process of bicarbocyclic skeleton formation shall take place according to the domino mechanism, via [2+4] heterocycloadduct. On the other hand, along the path leading finally to bicyclo[2.2.1]hept-5-ene with a nitro group in exo orientation, acyclic adduct with a zwitterionic nature is formed in the first reaction, which undergoes cyclisation next in the second step of the reaction.

  19. Control derivative to optimal control analysis | Omolehin | Journal of ...

    African Journals Online (AJOL)

    Optimal control theory, generally, is to determine the control signals which will cause a process to satisfy the physical constraints and at the same time optimize some performance criterion. In this work, a numerical method for finding solution to linear optimal control problems with bounded state constraints is examined.

  20. Extremal Optimization: Methods Derived from Co-Evolution

    Energy Technology Data Exchange (ETDEWEB)

    Boettcher, S.; Percus, A.G.

    1999-07-13

    We describe a general-purpose method for finding high-quality solutions to hard optimization problems, inspired by self-organized critical models of co-evolution such as the Bak-Sneppen model. The method, called Extremal Optimization, successively eliminates extremely undesirable components of sub-optimal solutions, rather than ''breeding'' better components. In contrast to Genetic Algorithms which operate on an entire ''gene-pool'' of possible solutions, Extremal Optimization improves on a single candidate solution by treating each of its components as species co-evolving according to Darwinian principles. Unlike Simulated Annealing, its non-equilibrium approach effects an algorithm requiring few parameters to tune. With only one adjustable parameter, its performance proves competitive with, and often superior to, more elaborate stochastic optimization procedures. We demonstrate it here on two classic hard optimization problems: graph partitioning and the traveling salesman problem.

  1. Techniques for optimizing nanotips derived from frozen taylor cones

    Science.gov (United States)

    Hirsch, Gregory

    2017-12-05

    Optimization techniques are disclosed for producing sharp and stable tips/nanotips relying on liquid Taylor cones created from electrically conductive materials with high melting points. A wire substrate of such a material with a preform end in the shape of a regular or concave cone, is first melted with a focused laser beam. Under the influence of a high positive potential, a Taylor cone in a liquid/molten state is formed at that end. The cone is then quenched upon cessation of the laser power, thus freezing the Taylor cone. The tip of the frozen Taylor cone is reheated by the laser to allow its precise localized melting and shaping. Tips thus obtained yield desirable end-forms suitable as electron field emission sources for a variety of applications. In-situ regeneration of the tip is readily accomplished. These tips can also be employed as regenerable bright ion sources using field ionization/desorption of introduced chemical species.

  2. Optimized Tetrazine Derivatives for Rapid Bioorthogonal Decaging in Living Cells.

    Science.gov (United States)

    Fan, Xinyuan; Ge, Yun; Lin, Feng; Yang, Yi; Zhang, Gong; Ngai, William Shu Ching; Lin, Zhi; Zheng, Siqi; Wang, Jie; Zhao, Jingyi; Li, Jie; Chen, Peng R

    2016-11-02

    The inverse-electron-demand Diels-Alder (iDA) reaction has recently been repurposed as a bioorthogonal decaging reaction by accelerating the elimination process after an initial cycloaddition between trans-cyclooctene (TCO) and tetrazine (TZ). Herein, we systematically surveyed 3,6-substituted TZ derivatives by using a fluorogenic TCO-coumarin reporter followed by LC-MS analysis, which revealed that the initial iDA cycloaddition step was greatly accelerated by electron-withdrawing groups (EWGs) while the subsequent elimination step was strongly suppressed by EWGs. In addition, smaller substituents facilitated the decaging process. These findings promoted us to design and test unsymmetric TZs bearing an EWG group and a small non-EWG group at the 3- and 6-position, respectively. These TZs showed remarkably enhanced decaging rates, enabling rapid iDA-mediated protein activation in living cells. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Steam generators lay-up optimization and derived wastes reduction

    Energy Technology Data Exchange (ETDEWEB)

    Rabeau, A.M.; Viricel, L. [Electricite de France, Group de Laboratoires (France); Foct, F. [Electricite de France, Dept. MMC (France); Lemaire, P. [Electricite de France, Groupe Maintenance Chaudiere (France); Moreaux, D. [Electricite de France, Groupe Environnement (France)

    2002-07-01

    Today, EDF plants face a new release permit after a steam generators (SGs) wet lay-up, so that the legal authorizations for wastes release to the environment, renewed or being renewed by the safety authorities, allow smallest quantities of wastes than earlier. In this context, EDF studies the optimization of SGs lay-up conditions, and especially of the hydrazine concentration, in order to reduce the liquid wastes releases to the environment, while keeping low corrosion conditions. At the same time, EDF examines a treatment for hydrazine elimination in liquid wastes before their releases. An experimental study has been conducted in order to evaluate the efficiency of hydrazine to control materials corrosion and of nitrogen gas phase to deaerate water. The consequences of lay-up conditions on carbon steel corrosion has also been studied. In the absence of an efficient alternative reagent, hydrazine remains necessary but implies a great care due to its carcinogenic risks and to its toxicity for aquatic organisms. This choice implies studying a method for hydrazine elimination before its release to the environment. The hydrazine elimination from SGs lay-up wastes could be achieved within about one day, by adding about 700 to 800 liters of 30% hydrogen peroxide solution to eliminate 100 kg hydrazine. Copper sulfate would have to be added if copper is not present in the wastes; the copper content in the wastes should be around 100 to 200 {mu}g/kg for the reaction to be fast enough, which is consistent with the legal authorization for copper release to the environment. The nuclear power plants would have to adjust the quantity of hydrogen peroxide to add to the wastes to be treated, based on the quantity of hydrazine to eliminate, in order to avoid any excess of hydrogen peroxide in the wastes at the end of the treatment, since this species is not allowed to be released to the environment. Moreover, the hydrogen peroxide treatment should not have any significant impact on

  4. A Generalized Hopfield Network for Nonsmooth Constrained Convex Optimization: Lie Derivative Approach.

    Science.gov (United States)

    Li, Chaojie; Yu, Xinghuo; Huang, Tingwen; Chen, Guo; He, Xing

    2016-02-01

    This paper proposes a generalized Hopfield network for solving general constrained convex optimization problems. First, the existence and the uniqueness of solutions to the generalized Hopfield network in the Filippov sense are proved. Then, the Lie derivative is introduced to analyze the stability of the network using a differential inclusion. The optimality of the solution to the nonsmooth constrained optimization problems is shown to be guaranteed by the enhanced Fritz John conditions. The convergence rate of the generalized Hopfield network can be estimated by the second-order derivative of the energy function. The effectiveness of the proposed network is evaluated on several typical nonsmooth optimization problems and used to solve the hierarchical and distributed model predictive control four-tank benchmark.

  5. A Requirements-Driven Optimization Method for Acoustic Liners Using Analytic Derivatives

    Science.gov (United States)

    Berton, Jeffrey J.; Lopes, Leonard V.

    2017-01-01

    More than ever, there is flexibility and freedom in acoustic liner design. Subject to practical considerations, liner design variables may be manipulated to achieve a target attenuation spectrum. But characteristics of the ideal attenuation spectrum can be difficult to know. Many multidisciplinary system effects govern how engine noise sources contribute to community noise. Given a hardwall fan noise source to be suppressed, and using an analytical certification noise model to compute a community noise measure of merit, the optimal attenuation spectrum can be derived using multidisciplinary systems analysis methods. In a previous paper on this subject, a method deriving the ideal target attenuation spectrum that minimizes noise perceived by observers on the ground was described. A simple code-wrapping approach was used to evaluate a community noise objective function for an external optimizer. Gradients were evaluated using a finite difference formula. The subject of this paper is an application of analytic derivatives that supply precise gradients to an optimization process. Analytic derivatives improve the efficiency and accuracy of gradient-based optimization methods and allow consideration of more design variables. In addition, the benefit of variable impedance liners is explored using a multi-objective optimization.

  6. Development of an ensemble-adjoint optimization approach to derive uncertainties in net carbon fluxes

    Directory of Open Access Journals (Sweden)

    T. Ziehn

    2011-11-01

    Full Text Available Accurate modelling of the carbon cycle strongly depends on the parametrization of its underlying processes. The Carbon Cycle Data Assimilation System (CCDAS can be used as an estimator algorithm to derive posterior parameter values and uncertainties for the Biosphere Energy Transfer and Hydrology scheme (BETHY. However, the simultaneous optimization of all process parameters can be challenging, due to the complexity and non-linearity of the BETHY model. Therefore, we propose a new concept that uses ensemble runs and the adjoint optimization approach of CCDAS to derive the full probability density function (PDF for posterior soil carbon parameters and the net carbon flux at the global scale. This method allows us to optimize only those parameters that can be constrained best by atmospheric carbon dioxide (CO2 data. The prior uncertainties of the remaining parameters are included in a consistent way through ensemble runs, but are not constrained by data. The final PDF for the optimized parameters and the net carbon flux are then derived by superimposing the individual PDFs for each ensemble member. We find that the optimization with CCDAS converges much faster, due to the smaller number of processes involved. Faster convergence also gives us much increased confidence that we find the global minimum in the reduced parameter space.

  7. A novel optimal PID plus second order derivative controller for AVR system

    Directory of Open Access Journals (Sweden)

    Mouayad A. Sahib

    2015-06-01

    Full Text Available This paper proposes a novel controller for automatic voltage regulator (AVR system. The controller is a four term control type consisting of proportional, integral, derivative, and second order derivative terms (PIDD2. The four parameters of the proposed controller are optimized using particle swarm optimization (PSO algorithm. The performance of the proposed PIDD2 is compared with various PID controllers tuned by modern heuristic optimization algorithms. In addition, a comparison with the fractional order PID (FOPID controller tuned by Chaotic Ant Swarm (CAS algorithm is also performed. Furthermore, a frequency response, zero-pole map, and robustness analysis of the AVR system with PIDD2 is performed. Practical implementation issues of the proposed controller are also addressed. Simulation results showed a superior response performance of the PIDD2 controller in comparison to PID and FOPID controllers. Moreover, the proposed PIDD2 can highly improve the system robustness with respect to model uncertainties.

  8. Topology optimization based on spline-based meshfree method using topological derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Hur, Junyoung; Youn, Sung-Kie [KAIST, Daejeon (Korea, Republic of); Kang, Pilseong [Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of)

    2017-05-15

    Spline-based meshfree method (SBMFM) is originated from the Isogeometric analysis (IGA) which integrates design and analysis through Non-uniform rational B-spline (NURBS) basis functions. SBMFM utilizes trimming technique of CAD system by representing the domain using NURBS curves. In this work, an explicit boundary topology optimization using SBMFM is presented with an effective boundary update scheme. There have been similar works in this subject. However unlike the previous works where semi-analytic method for calculating design sensitivities is employed, the design update is done by using topological derivatives. In this research, the topological derivative is used to derive the sensitivity of boundary curves and for the creation of new holes. Based on the values of topological derivatives, the shape of boundary curves is updated. Also, the topological change is achieved by insertion and removal of the inner holes. The presented approach is validated through several compliance minimization problems.

  9. A General Class of Derivative Free Optimal Root Finding Methods Based on Rational Interpolation

    Directory of Open Access Journals (Sweden)

    Fiza Zafar

    2015-01-01

    Full Text Available We construct a new general class of derivative free n-point iterative methods of optimal order of convergence 2n-1 using rational interpolant. The special cases of this class are obtained. These methods do not need Newton’s iterate in the …first step of their iterative schemes. Numerical computations are presented to show that the new methods are efficient and can be seen as better alternates.

  10. Development and optimization of the synthesis of new thiazolidin-4-one derivatives of ibuprofen.

    Science.gov (United States)

    Vasincu, Ioana; Apotrosoaei, Maria; Panzariu, Andreea; Buron, F; Routier, S; Profire, Lenuta

    2014-01-01

    Ibuprofen, an important nonsteroidal anti-inflammatory agent, is one of the most prescribed drugs for the treatment of pain and inflammation from various rheumatic diseases, but some side effects can occur on long-term use. The method for synthesis optimization of new derivatives of Ibuprofen with thiazolidin-4-one moiety, with improved pharmacological and toxicological profile. To optimize the derivatization method of free carboxyl group of Ibuprofen (2-(4-isobutylphenyl)propionic acid) the reaction conditions were varied (reagent ratio, catalyst, reaction medium). The most favorable method was proved to be the reaction between ibuprofen hydrazone and mercaptoacetic acid, in excess, at 80-85 degrees C, for 6 h with 96% conversion rate. The synthesis of 2-phenyl-3-[2-(4-(isobutyl)phenyl)-2-methyl]acetamido-thiazolidin-4-one derivative was optimized in view of applying it as a general procedure for the synthesis of other derivatives with related structure. The chemical structure and molecular weight of the synthesized compound were confirmed by spectral methods (IR, 1H NMR, 13C NMR, HR-MS).

  11. Derivative Trade Optimizing Model Utilizing GP Based on Behavioral Finance Theory

    Science.gov (United States)

    Matsumura, Koki; Kawamoto, Masaru

    This paper proposed a new technique which makes the strategy trees for the derivative (option) trading investment decision based on the behavioral finance theory and optimizes it using evolutionary computation, in order to achieve high profitability. The strategy tree uses a technical analysis based on a statistical, experienced technique for the investment decision. The trading model is represented by various technical indexes, and the strategy tree is optimized by the genetic programming(GP) which is one of the evolutionary computations. Moreover, this paper proposed a method using the prospect theory based on the behavioral finance theory to set psychological bias for profit and deficit and attempted to select the appropriate strike price of option for the higher investment efficiency. As a result, this technique produced a good result and found the effectiveness of this trading model by the optimized dealings strategy.

  12. 40 CFR 721.4486 - Propanoic acid, 2-methyl-, (1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, rel-.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Propanoic acid, 2-methyl-, (1R,2R,4R...,4R)-1,7,7-trimethylbicyclo hept-2-yl ester, rel-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified as propanoic acid, 2-methyl-, (1R,2R,4R)-1,7...

  13. Velocity-based cardiac contractility personalization from images using derivative-free optimization.

    Science.gov (United States)

    Wong, Ken C L; Sermesant, Maxime; Rhode, Kawal; Ginks, Matthew; Rinaldi, C Aldo; Razavi, Reza; Delingette, Hervé; Ayache, Nicholas

    2015-03-01

    Model personalization is a key aspect for biophysical models to impact clinical practice, and cardiac contractility personalization from medical images is a major step in this direction. Existing gradient-based optimization approaches show promising results of identifying the maximum contractility from images, but the contraction and relaxation rates are not accounted for. A main reason is the limited choices of objective functions when their gradients are required. For complicated cardiac models, analytical evaluations of gradients are very difficult if not impossible, and finite difference approximations are computationally expensive and may introduce numerical difficulties. By removing such limitations with derivative-free optimization, we found that a velocity-based objective function can properly identify regional maximum contraction stresses, contraction rates, and relaxation rates simultaneously with intact model complexity. Experiments on synthetic data show that the parameters are better identified using the velocity-based objective function than its position-based counterpart, and the proposed framework is insensitive to initial parameters with the adopted derivative-free optimization algorithm. Experiments on clinical data show that the framework can provide personalized contractility parameters which are consistent with the underlying physiologies of the patients and healthy volunteers. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Proportional–Integral–Derivative (PID Controller Tuning using Particle Swarm Optimization Algorithm

    Directory of Open Access Journals (Sweden)

    J. S. Bassi

    2012-08-01

    Full Text Available The proportional-integral-derivative (PID controllers are the most popular controllers used in industry because of their remarkable effectiveness, simplicity of implementation and broad applicability. However, manual tuning of these controllers is time consuming, tedious and generally lead to poor performance. This tuning which is application specific also deteriorates with time as a result of plant parameter changes. This paper presents an artificial intelligence (AI method of particle swarm optimization (PSO algorithm for tuning the optimal proportional-integral derivative (PID controller parameters for industrial processes. This approach has superior features, including easy implementation, stable convergence characteristic and good computational efficiency over the conventional methods. Ziegler- Nichols, tuning method was applied in the PID tuning and results were compared with the PSO-Based PID for optimum control. Simulation results are presented to show that the PSO-Based optimized PID controller is capable of providing an improved closed-loop performance over the Ziegler- Nichols tuned PID controller Parameters. Compared to the heuristic PID tuning method of Ziegler-Nichols, the proposed method was more efficient in improving the step response characteristics such as, reducing the steady-states error; rise time, settling time and maximum overshoot in speed control of DC motor.

  15. Derivation of Optimal Cropping Pattern in Part of Hirakud Command using Cuckoo Search

    Science.gov (United States)

    Rath, Ashutosh; Biswal, Sudarsan; Samantaray, Sandeep; Swain, Prakash Chandra, PROF.

    2017-08-01

    The economicgrowth of a Nation depends on agriculture which relies on the obtainable water resources, available land and crops. The contribution of water in an appropriate quantity at appropriate time plays avitalrole to increase the agricultural production. Optimal utilization of available resources can be achieved by proper planning and management of water resources projects and adoption of appropriate technology. In the present work, the command area of Sambalpur distribrutary System is taken up for investigation. Further, adoption of a fixed cropping pattern causes the reduction of yield. The present study aims at developing different crop planning strategies to increase the net benefit from the command area with minimum investment. Optimization models are developed for Kharif season using LINDO and Cuckoo Search (CS) algorithm for maximization of the net benefits. In process of development of Optimization model the factors such as cultivable land, seeds, fertilizers, man power, water cost, etc. are taken as constraints. The irrigation water needs of major crops and the total available water through canals in the command of Sambalpur Distributary are estimated. LINDO and Cuckoo Search models are formulated and used to derive the optimal cropping pattern yielding maximum net benefits. The net benefits of Rs.585.0 lakhs in Kharif Season are obtained by adopting LINGO and 596.07 lakhs from Cuckoo Search, respectively, whereas the net benefits of 447.0 lakhs is received by the farmers of the locality with the adopting present cropping pattern.

  16. HEK293 cell culture media study towards bioprocess optimization: Animal derived component free and animal derived component containing platforms.

    Science.gov (United States)

    Liste-Calleja, Leticia; Lecina, Martí; Cairó, Jordi Joan

    2014-04-01

    The increasing demand for biopharmaceuticals produced in mammalian cells has lead industries to enhance bioprocess volumetric productivity through different strategies. Among those strategies, cell culture media development is of major interest. In the present work, several commercially available culture media for Human Embryonic Kidney cells (HEK293) were evaluated in terms of maximal specific growth rate and maximal viable cell concentration supported. The main objective was to provide different cell culture platforms which are suitable for a wide range of applications depending on the type and the final use of the product obtained. Performing simple media supplementations with and without animal derived components, an enhancement of cell concentration from 2 × 10(6) cell/mL to 17 × 10(6) cell/mL was achieved in batch mode operation. Additionally, the media were evaluated for adenovirus production as a specific application case of HEK293 cells. None of the supplements interfered significantly with the adenovirus infection although some differences were encountered in viral productivity. To the best of our knowledge, the high cell density achieved in the work presented has never been reported before in HEK293 batch cell cultures and thus, our results are greatly promising to further study cell culture strategies in bioreactor towards bioprocess optimization. Copyright © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  17. Approximate analytical solution of diffusion equation with fractional time derivative using optimal homotopy analysis method

    Directory of Open Access Journals (Sweden)

    S. Das

    2013-12-01

    Full Text Available In this article, optimal homotopy-analysis method is used to obtain approximate analytic solution of the time-fractional diffusion equation with a given initial condition. The fractional derivatives are considered in the Caputo sense. Unlike usual Homotopy analysis method, this method contains at the most three convergence control parameters which describe the faster convergence of the solution. Effects of parameters on the convergence of the approximate series solution by minimizing the averaged residual error with the proper choices of parameters are calculated numerically and presented through graphs and tables for different particular cases.

  18. Evaluation and optimization of chitosan derivatives-based gene delivery system via kidney epithelial cells

    Directory of Open Access Journals (Sweden)

    S. Safari

    2012-06-01

    Full Text Available Purpose: Non-viral vectors have been widely proposed as safer alternatives to viral vectors, and cationic polymers have gained increasing attention because they can form self-assembly with DNA. Chitosan is also considered to be a good candidate for gene delivery systems, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low solubility and transfection efficiency need to be overcome prior to clinical trial. In this work, we focus on alkyl modified chitosan which might be useful in DNA condensing and efficient gene delivery. Methods: N, N- Diethyl N- Methyl (DEMC and N- Triethyl Chitosan (TEC were synthesized from chitosan polymer. In order to optimize the polymers for gene delivery, we used FITC-dextran (FD. Then the optimized polymer concentrations were used for gene delivery. Fluorescent microscope was used, in order to evaluate the polymers’ efficiency for gene delivery to human embryonic kidney epithelial cells (HEK 293T. Results: This modification increased chitosan’s positive charge, thus these chitosan derivatives spontaneously formed complexes with FD, green fluorescence protein plasmid DNA (pEGFP, red fluorescence protein plasmid DNA (pJred and fluorescent labeled miRNA. Results gained from fluorescent microscope showed that TEC and DEMC were able to transfer FD, DNA and miRNA (micro RNA to HEK cell line. Conclusion: We conclude that these chitosan derivatives present suitable characteristics to be used as non-viral gene delivery vectors to epithelial cells.

  19. The optimization of saccharification of desulfurated red seaweed-derived polysaccharides and analysis of their composition.

    Science.gov (United States)

    Li, Xiaolin; Li, Yinping; Mou, Haijin; Gao, Yan; Hwang, Hueymin; Wang, Peng

    2014-01-01

    Currently processes of ethanol production from desulfurated red seaweed derived polysaccharides (De-RSDP) are well established. However, the optimization of the enzymatic saccharification process has not been reported. In this study, De-RSDP from Kappaphycus alvarezii was subjected to saccharification by different enzymes, including pectinase, cellobiase, cellulase, and hemicellulase. The best saccharification enzyme was determined as pectinase. In order to obtain more reducing sugar (RS), the single-factor experiment followed by central composite rotatable design (CCD) was used to optimize the parameters for enzymatic hydrolysis. The optimal saccharification parameters of De-RSDP were 4400 U/g pectinase dosage, 96 hr, and 55.5°C, respectively, and the yield of RS reached 81.3%. Subsequently, the saccharification liquids of De-RSDP were isolated and purified with gel permeation chromatography (GPC) to separate saccharides with different molecular weights. Simultaneously, the composition of saccharification liquids was analyzed by 1-phenyl-3-methyl-5-pyrazolone high-pressure liquid chromatography (PMP-HPLC) and mass spectroscopy (MS). The result showed that the content is mainly composed of galactose (65.2%) with the average molecular mass in the fourth peak 181.1 Da. The saccharification liquids of De-RSDP inoculated with Saccharomyces cerevisiae L-4 for ethanol fermentation produced 0.3 g ethanol/g De-RSDP, which corresponded to 71.8% of the theoretical yield (0.38 g ethanol/g).

  20. Integration of ab-initio nuclear calculation with derivative free optimization technique

    Energy Technology Data Exchange (ETDEWEB)

    Sharda, Anurag [Iowa State Univ., Ames, IA (United States)

    2008-01-01

    Optimization techniques are finding their inroads into the field of nuclear physics calculations where the objective functions are very complex and computationally intensive. A vast space of parameters needs searching to obtain a good match between theoretical (computed) and experimental observables, such as energy levels and spectra. Manual calculation defies the scope of such complex calculation and are prone to error at the same time. This body of work attempts to formulate a design and implement it which would integrate the ab initio nuclear physics code MFDn and the VTDIRECT95 code. VTDIRECT95 is a Fortran95 suite of parallel code implementing the derivative-free optimization algorithm DIRECT. Proposed design is implemented for a serial and parallel version of the optimization technique. Experiment with the initial implementation of the design showing good matches for several single-nucleus cases are conducted. Determination and assignment of appropriate number of processors for parallel integration code is implemented to increase the efficiency and resource utilization in the case of multiple nuclei parameter search.

  1. Aeromonas punctata derived depolymerase that disrupts the integrity of Klebsiella pneumoniae capsule: optimization of depolymerase production.

    Science.gov (United States)

    Bansal, Shruti; Soni, Sanjeev Kumar; Harjai, Kusum; Chhibber, Sanjay

    2014-07-01

    Formation of dense, highly hydrated biofilm structures pose a risk for public and environmental health. Extracellular polymeric substances encompassing biofilms offer 1000-fold greater resistance as compared to the planktonic cells. Using enzymes as anti-biofouling agents, will improve penetration of antimicrobials and increase susceptibility of biofilms to components of immune system. The challenge of using enzymes derived from unrelated bacteria for the degradation of capsular matrix of Klebsiella pneumoniae has not been dealt in the past. Thus, statistical optimization was done to enhance depolymerase production by Aeromonas punctata, directed against the exopolysaccharide matrix of Klebsiella pneumoniae B5055, capable of substituting the available phage borne depolymerase enzyme. Optimization via central composite design (CCD) resulted in 16-fold enhancement in depolymerase yield (166.65 µmoles ml(-1)  min(-1) ) over unoptimized medium. Out of the 19 variables, media composition giving maximum expression levels of the enzyme consisted of 1 mg ml(-1) galactose and ammonium chloride, 1.5 mg ml(-1) each of capsular polysaccharide (CPS) and magnesium sulfate. Tryptic peptide analysis of the purified 29 kDa band by Matrix assisted laser desorption ionization-time of flight (MALDI-TOF) showed a high homology with a protein of unknown function from Aeromonas cavaie Ae398. Further improvements in the enzyme can lead to its successful development as prophylactic and/or a therapeutic agent. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. An inequality for detecting financial fraud, derived from the Markowitz Optimal Portfolio Theory

    Science.gov (United States)

    Bard, Gregory V.

    2016-12-01

    The Markowitz Optimal Portfolio Theory, published in 1952, is well-known, and was often taught because it blends Lagrange Multipliers, matrices, statistics, and mathematical finance. However, the theory faded from prominence in American investing, as Business departments at US universities shifted from techniques based on mathematics, finance, and statistics, to focus instead on leadership, public speaking, interpersonal skills, advertising, etc… The author proposes a new application of Markowitz's Theory: the detection of a fairly broad category of financial fraud (called "Ponzi schemes" in American newspapers) by looking at a particular inequality derived from the Markowitz Optimal Portfolio Theory, relating volatility and expected rate of return. For example, one recent Ponzi scheme was that of Bernard Madoff, uncovered in December 2008, which comprised fraud totaling 64,800,000,000 US dollars [23]. The objective is to compare investments with the "efficient frontier" as predicted by Markowitz's theory. Violations of the inequality should be impossible in theory; therefore, in practice, violations might indicate fraud.

  3. Synthesis and Anti-HIV-1 Activity of New Fluoro-HEPT Analogues: An Investigation on Fluoro versus Hydroxy Substituents

    DEFF Research Database (Denmark)

    Loksha, Yasser M; Pedersen, Erik Bjerregaard; Loddo, Roberta

    2011-01-01

    Coupling of 6-benzyl-5-hydroxymethyluracil (1) with formaldehyde acetals followed by fluorination using (diethylamino)sulfur trifluoride (DAST) afforded 1-alkenyloxymethyl and 1-propargyloxymethyl 5-fluoromethyl-6-benzyluracils 3a-c. 6-(3,5-Dimethylbenzyl)-5-ethyl-1-[(2-fluoroethoxy......)methyl]pyrimidine-2,4(1H,3H)-dione (6) was synthesized by fluorination of the corresponding hydroxy derivative 5. Sonogoshira reaction was performed on 6-(3,5-dimethylbenzyl)-5-ethyl-1-(4-iodobenzyl)uracil (7) with propargyl alcohol to afford 8 which was fluorinated to give the fluoro propargyl derivative 9. Compound...

  4. Optimized Production of Coal Fly Ash Derived Synthetic Zeolites for Mercury Removal from Wastewater

    Science.gov (United States)

    Tauanov, Z.; Shah, D.; Itskos, G.; Inglezakis, V.

    2017-09-01

    Coal fly ash (CFA) derived synthetic zeolites have become popular with recent advances and its ever-expanding range of applications, particularly as an adsorbent for water and gas purification and as a binder or additive in the construction industry and agriculture. Among these applications, perpetual interest has been in utilization of CFA derived synthetic zeolites for removal of heavy metals from wastewater. We herein focus on utilization of locally available CFA for efficient adsorption of mercury from wastewater. To this end, experimental conditions were investigated so that to produce synthetic zeolites from Kazakhstani CFAs with conversion into zeolite up to 78%, which has remarkably high magnetite content. In particular, the effect of synthesis reaction temperature, reaction time, and loading of adsorbent were systematically investigated and optimized. All produced synthetic zeolites and the respective CFAs were characterized using XRD, XRF, PSA and porosimetric instruments to obtain microstructural and mineralogical data. Furthermore, the synthesized zeolites were studied for the removal of mercury from aqueous solutions. A comparison of removal eficiency and its relationship to the physical and chemical properties of the synthetic zeolites were analyzed and interpreted.

  5. Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin.

    Science.gov (United States)

    Baik, Jong Youn; Dahodwala, Hussain; Oduah, Eziafa; Talman, Lee; Gemmill, Trent R; Gasimli, Leyla; Datta, Payel; Yang, Bo; Li, Guoyun; Zhang, Fuming; Li, Lingyun; Linhardt, Robert J; Campbell, Andrew M; Gorfien, Stephen F; Sharfstein, Susan T

    2015-07-01

    Heparin is the most widely used anticoagulant drug in the world today. Heparin is currently produced from animal tissues, primarily porcine intestines. A recent contamination crisis motivated development of a non-animal-derived source of this critical drug. We hypothesized that Chinese hamster ovary (CHO) cells could be metabolically engineered to produce a bioengineered heparin, equivalent to current pharmaceutical heparin. We previously engineered CHO-S cells to overexpress two exogenous enzymes from the heparin/heparan sulfate biosynthetic pathway, increasing the anticoagulant activity ∼100-fold and the heparin/heparan sulfate yield ∼10-fold. Here, we explored the effects of bioprocess parameters on the yield and anticoagulant activity of the bioengineered GAGs. Fed-batch shaker-flask studies using a proprietary, chemically-defined feed, resulted in ∼two-fold increase in integrated viable cell density and a 70% increase in specific productivity, resulting in nearly three-fold increase in product titer. Transferring the process to a stirred-tank bioreactor increased the productivity further, yielding a final product concentration of ∼90 μg/mL. Unfortunately, the product composition still differs from pharmaceutical heparin, suggesting that additional metabolic engineering will be required. However, these studies clearly demonstrate bioprocess optimization, in parallel with metabolic engineering refinements, will play a substantial role in developing a bioengineered heparin to replace the current animal-derived drug. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Derivative-free neural network for optimizing the scoring functions associated with dynamic programming of pairwise-profile alignment.

    Science.gov (United States)

    Yamada, Kazunori D

    2018-01-01

    A profile-comparison method with position-specific scoring matrix (PSSM) is among the most accurate alignment methods. Currently, cosine similarity and correlation coefficients are used as scoring functions of dynamic programming to calculate similarity between PSSMs. However, it is unclear whether these functions are optimal for profile alignment methods. By definition, these functions cannot capture nonlinear relationships between profiles. Therefore, we attempted to discover a novel scoring function, which was more suitable for the profile-comparison method than existing functions, using neural networks. Although neural networks required derivative-of-cost functions, the problem being addressed in this study lacked them. Therefore, we implemented a novel derivative-free neural network by combining a conventional neural network with an evolutionary strategy optimization method used as a solver. Using this novel neural network system, we optimized the scoring function to align remote sequence pairs. Our results showed that the pairwise-profile aligner using the novel scoring function significantly improved both alignment sensitivity and precision relative to aligners using existing functions. We developed and implemented a novel derivative-free neural network and aligner (Nepal) for optimizing sequence alignments. Nepal improved alignment quality by adapting to remote sequence alignments and increasing the expressiveness of similarity scores. Additionally, this novel scoring function can be realized using a simple matrix operation and easily incorporated into other aligners. Moreover our scoring function could potentially improve the performance of homology detection and/or multiple-sequence alignment of remote homologous sequences. The goal of the study was to provide a novel scoring function for profile alignment method and develop a novel learning system capable of addressing derivative-free problems. Our system is capable of optimizing the performance of other

  7. Optimization of tyrosine-derived polycarbonate terpolymers for bone regeneration scaffolds

    Science.gov (United States)

    Resurreccion-Magno, Maria Hanshella C.

    Tyrosine-derived polycarbonates (TyrPC) are a versatile class of polymers highly suitable for bone tissue engineering. Among the tyrosine-derived polycarbonates, poly(DTE carbonate) has an FDA masterfile that documents its biocompatibility and non-toxicity and has shown potential utility in orthopedics due to its osteoconductive properties and strength. DTE stands for desaminotyrosyl-tyrosine ethyl ester and is the most commonly used tyrosine-derived monomer. However, in vitro degradation studies showed that poly(DTE carbonate) did not completely resorb even after four years of incubation in phosphate buffered saline. Thus for bone regeneration, which only requires a temporary implant until the bone heals, poly(DTE carbonate) would not be the best choice. The goal of the present research was to optimize a scaffold composition for bone regeneration that is based on desaminotyrosyl-tyrosine alkyl ester (DTR), desaminotyrosyl-tyrosine (DT) and poly(ethylene glycol) (PEG). Five areas of research were presented: (1) synthesis and characterization of a focused library of TyrPC terpolymers; (2) evaluation of the effects of how small changes on the composition affected the mechanism and kinetics of polymer degradation and erosion; (3) fabrication of bioactive three-dimensional porous scaffold constructs for bone regeneration; (4) assessment of osteogenic properties in vitro using pre-osteoblasts; and (5) evaluation of bone regeneration potential, with or without recombinant human bone morphogenetic protein-2 (rhBMP-2), in vivo using a critical sized defect (CSD) rabbit calvaria (cranium) model. Small changes in the composition, such as changing the R group of DTR from ethyl to methyl, varying the mole percentages of DT and PEG, and using a different PEG block length, affected the overall properties of these polymers. Porous scaffolds were prepared by a combination of solvent casting, porogen leaching and phase separation techniques. Calcium phosphate was coated on the

  8. Design of Optimal Proportional Integral Derivative Based Power System Stabilizer Using Bat Algorithm

    Directory of Open Access Journals (Sweden)

    Dhanesh K. Sambariya

    2016-01-01

    Full Text Available The design of a proportional, derivative, and integral (PID based power system stabilizer (PSS is carried out using the bat algorithm (BA. The design of proposed PID controller is considered with an objective function based on square error minimization to enhance the small signal stability of nonlinear power system for a wide range of operating conditions. Three benchmark power system models as single-machine infinite-bus (SMIB power system, two-area four-machine ten-bus power system, and IEEE New England ten-machine thirty-nine-bus power system are considered to examine the effectiveness of the designed controller. The BA optimized PID based PSS (BA-PID-PSS controller is applied to these benchmark systems, and the performance is compared with controllers reported in literature. The robustness is tested by considering eight plant conditions of each system, representing the wide range of operating conditions. It includes unlike loading conditions and system configurations to establish the superior performance with BA-PID-PSS over-the-counter controllers.

  9. Photoinjector optimization using a derivative-free, model-based trust-region algorithm for the Argonne Wakefield Accelerator

    Science.gov (United States)

    Neveu, N.; Larson, J.; Power, J. G.; Spentzouris, L.

    2017-07-01

    Model-based, derivative-free, trust-region algorithms are increasingly popular for optimizing computationally expensive numerical simulations. A strength of such methods is their efficient use of function evaluations. In this paper, we use one such algorithm to optimize the beam dynamics in two cases of interest at the Argonne Wakefield Accelerator (AWA) facility. First, we minimize the emittance of a 1 nC electron bunch produced by the AWA rf photocathode gun by adjusting three parameters: rf gun phase, solenoid strength, and laser radius. The algorithm converges to a set of parameters that yield an emittance of 1.08 μm. Second, we expand the number of optimization parameters to model the complete AWA rf photoinjector (the gun and six accelerating cavities) at 40 nC. The optimization algorithm is used in a Pareto study that compares the trade-off between emittance and bunch length for the AWA 70MeV photoinjector.

  10. Nanoporous carbons derived from binary carbides and their optimization for hydrogen storage

    Science.gov (United States)

    Dash, Ranjan Kumar

    On-board hydrogen storage is one of the major hurdles for success of hydrogen economy. Hydrogen storage using physisorption technique demands highly porous materials. Carbide derived carbons (CDC), a new class of porous carbons produced by thermo chemical etching of metal atoms from carbides were selected as a method for producing highly porous material for hydrogen storage. In order to synthesize tunable nanoporous carbon and to establish a structure-property relation between initial metal carbide and resultant nanoporous carbon, CDCs were synthesized from four metal carbides, two that have uniform carbon to carbon distance in the lattice structure (ZrC, TiC and SiC) and one that has a non-uniform carbon distribution in the lattice (B4C). It was shown that a uniform distribution of carbon atoms in the carbide is important for obtaining a narrow pore size distribution (PSD). CDC derived from B 4C had a relatively broad PSD and contained mesopores even at the lowest synthesis temperature, while the CDC produced from SiC maintained a narrow PSD even at the synthesis temperature of 1200°C. CDC produced from ZrC and TiC has a narrow PSD at low synthesis temperature and pores gets wider at higher temperatures. Comparison of CDCs produced from ZrC, TiC and B 4C shows that CDCs produced from ZrC and TiC show a lower degree of ordering than that from B4C at high temperatures. Unlike CDCs produced from ZrC and TiC, the PSD of CDCs from B4C does not change appreciably in the 600-1200°C range. CDCs produced from ZrC and TiC can have both narrowly distributed micropores (pores smaller than 2 nm) and mesopores (pores larger than 2 nm), depending on synthesis temperature. In this work, it is demonstrated that porosity of CDC can be fine tuned with a high accuracy by using different starting carbides and varying the synthesis temperatures. This is very important in many applications of porous carbon, especially for gas storage. CDC from ZrC, TiC, B4C and SiC resulted in a

  11. Optimization of Integer Order Integrators for Deriving Improved Models of Their Fractional Counterparts

    Directory of Open Access Journals (Sweden)

    Maneesha Gupta

    2013-01-01

    Full Text Available Second and third order digital integrators (DIs have been optimized first using Particle Swarm Optimization (PSO with minimized error fitness function obtained by registering mean, median, and standard deviation values in different random iterations. Later indirect discretization using Continued Fraction Expansion (CFE has been used to ascertain a better fitting of proposed integer order optimized DIs into their corresponding fractional counterparts by utilizing their refined properties, now restored in them due to PSO algorithm. Simulation results for the comparisons of the frequency responses of proposed 2nd and 3rd order optimized DIs and proposed discretized mathematical models of half integrators based on them, with their respective existing operators, have been presented. Proposed integer order PSO optimized integrators as well as fractional order integrators (FOIs have been observed to outperform the existing recently published operators in their respective domains reasonably well in complete range of Nyquist frequency.

  12. Applications of matrix derivatives to optimization problems in statistical pattern recognition

    Science.gov (United States)

    Morrell, J. S.

    1975-01-01

    A necessary condition for a real valued Frechet differentiable function of a vector variable have an extremum at a vector x sub 0 is that the Frechet derivative vanishes at x sub 0. A relationship between Frechet differentials and matrix derivatives was established that obtains a necessary condition on the matrix derivative at an extrema. These results are applied to various scalar functions of matrix variables which occur in statistical pattern recognition.

  13. Parameter estimation of a pulp digester model with derivative-free optimization strategies

    Science.gov (United States)

    Seiça, João C.; Romanenko, Andrey; Fernandes, Florbela P.; Santos, Lino O.; Fernandes, Natércia C. P.

    2017-07-01

    The work concerns the parameter estimation in the context of the mechanistic modelling of a pulp digester. The problem is cast as a box bounded nonlinear global optimization problem in order to minimize the mismatch between the model outputs with the experimental data observed at a real pulp and paper plant. MCSFilter and Simulated Annealing global optimization methods were used to solve the optimization problem. While the former took longer to converge to the global minimum, the latter terminated faster at a significantly higher value of the objective function and, thus, failed to find the global solution.

  14. 5-Azido-4-dimethylamino-1-methyl-1,2,4-triazolium Hexafluoridophosphate and Derivatives

    Directory of Open Access Journals (Sweden)

    Gerhard Laus

    2016-02-01

    Full Text Available 5-Azido-4-(dimethylamino-1-methyl-1,2,4-triazolium hexafluoridophosphate was synthesized from the corresponding 5-bromo compound with NaN3. Reaction with bicyclo[2.2.1]hept-2-ene yielded a tricyclic aziridine, addition of an N-heterocyclic carbene resulted in a triazatrimethine cyanine, and reduction with triphenylphosphane gave the 5-amino derivative. The crystal structures of three nitrogen-rich salts were determined. Thermoanalysis of the cationic azide and triazene showed exothermal decomposition. The triazene exhibited negative solvatochromism in polar solvents involving the dipolarity π* and hydrogen-bond donor acidity α of the solvent.

  15. Separation of 20 coumarin derivatives using the capillary electrophoresis method optimized by a series of Doehlert experimental designs.

    Science.gov (United States)

    Woźniakiewicz, Michał; Gładysz, Marta; Nowak, Paweł M; Kędzior, Justyna; Kościelniak, Paweł

    2017-05-15

    The aim of this study was to develop the first CE-based method enabling separation of 20 structurally similar coumarin derivatives. To facilitate method optimization a series of three consequent Doehlert experimental designs with the response surface methodology was employed, using number of peaks and the adjusted time of analysis as the selected responses. Initially, three variables were examined: buffer pH, ionic strength and temperature (No. 1 Doehlert design). The optimal conditions provided only partial separation, on that account, several buffer additives were examined at the next step: organic cosolvents and cyclodextrin (No. 2 Doehlert design). The optimal cyclodextrin type was also selected experimentally. The most promising results were obtained for the buffers fortified with methanol, acetonitrile and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin. Since these additives may potentially affect acid-base equilibrium and ionization state of analytes, the third Doehlert design (No. 3) was used to reconcile concentration of these additives with optimal pH. Ultimately, the total separation of all 20 compounds was achieved using the borate buffer at basic pH 9.5 in the presence of 10mM cyclodextrin, 9% (v/v) acetonitrile and 36% (v/v) methanol. Identity of all compounds was confirmed using the in-lab build UV-VIS spectra library. The developed method succeeded in identification of coumarin derivatives in three real samples. It demonstrates a huge resolving power of CE assisted by addition of cyclodextrins and organic cosolvents. Our unique optimization approach, based on the three Doehlert designs, seems to be prospective for future applications of this technique. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Retailer’s optimal ordering policies with cash discount and progressive payment scheme derived algebraically

    Directory of Open Access Journals (Sweden)

    Alok kumar

    2011-10-01

    Full Text Available This study presents optimal ordering policies for retailer when supplier offers cash discount and two progressive payment schemes for paying of purchasing cost. If the retailer pays the outstanding amount before or at first trade credit period M, the supplier provides r_1cash discount and does not charge any interest. If the retailer pays after M but before or at the second trade period N offered by the supplier, the supplier provides r_2 cash discount and charges interest on unpaid balance at the rate 〖Ic〗_1 . If retailer pays the balance after N, (N>M then the supplier does not provide any cash discount but charges interest on unpaid balance at the rate 〖Ic〗_2. The primary objective of this paper is to minimize the total cost of inventory system. This paper develops an algebraic approach to determine the optimal cycle time, optimal order quantity and optimal relevant cost. Numerical example are also presented to illustrate the result of propose model and solution procedure developed.

  17. Optimized methods for preparation of 6I-(ω-sulfanyl-alkylene-sulfanyl-β-cyclodextrin derivatives

    Directory of Open Access Journals (Sweden)

    Eva Bednářová

    2016-02-01

    Full Text Available A general high-yielding method for the preparation of monosubstituted β-cyclodextrin derivatives which have attached a thiol group in position 6 is described. The thiol group is attached through linkers of different lengths and repeating units (ethylene glycol or methylene. The target compounds were characterized by IR, MS and NMR spectra. A simple method for their complete conversion to the corresponding disulfides as well as a method for the reduction of the disulfides back to the thiols is presented. Both, thiols and disulfides are derivatives usable for well-defined covalent attachment of cyclodextrin to gold or polydopamine-coated solid surfaces.

  18. Optimization Design of Structures Subjected to Transient Loads Using First and Second Derivatives of Dynamic Displacement and Stress

    Directory of Open Access Journals (Sweden)

    Qimao Liu

    2012-01-01

    Full Text Available This paper developed an effective optimization method, i.e., gradient-Hessian matrix-based method or second order method, of frame structures subjected to the transient loads. An algorithm of first and second derivatives of dynamic displacement and stress with respect to design variables is formulated based on the Newmark method. The inequality time-dependent constraint problem is converted into a sequence of appropriately formed time-independent unconstrained problems using the integral interior point penalty function method. The gradient and Hessian matrixes of the integral interior point penalty functions are also computed. Then the Marquardt's method is employed to solve unconstrained problems. The numerical results show that the optimal design method proposed in this paper can obtain the local optimum design of frame structures and sometimes is more efficient than the augmented Lagrange multiplier method.

  19. Defining desirable natural product derived anticancer drug space: optimization of molecular physicochemical properties and ADMET attributes

    Directory of Open Access Journals (Sweden)

    Deepika Singh

    2016-06-01

    Full Text Available As part of our endeavor to enhance survival of natural product derived drug candidates and to guide the medicinal chemist to design higher probability space for success in the anti cancer drug development area, we embarked on a detailed study of the property space for a collection of natural product derived anti cancer molecules. We carried out a comprehensive analysis of properties for 24 natural products derived anti cancer drugs including clinical development candidates and a set of 27 natural products derived anti cancer lead compounds. In particular, we focused on understanding the interplay among eight physicochemical properties including like partition coefficient (log P, distribution coefficient at pH=7.4 (log D, topological polar surface area (TPSA, molecular weight (MW, aqueous solubility (log S, number of hydrogen bond acceptors (HBA, number of hydrogen bond donors (HBD and number of rotatable bonds (nRot crucial for drug design and  relationships between physicochemical properties, ADME (absorption, distribution, metabolism, and elimination attributes, and in silico toxicity profile for these two sets of compounds. This analysis provides guidance for the chemist to modify the existing natural product scaffold or designing of new anti cancer molecules in a property space with increased probability of success and may lead to the identification of druglike candidates with favorable safety profiles that can successfully test hypotheses in the clinic.

  20. The use of sensor derived data in optimization along the Mine-Value-Chain

    NARCIS (Netherlands)

    Buxton, M.W.N.; Benndorf, J.

    2013-01-01

    Sensor derived data can add value across the mining operating chain ranging from resource definition, extraction, pre-concentration, mineral process monitoring and assessment of product quality. Most documented studies on sensors in mining focus on specific technologies for specific applications.

  1. Corpus-Based Optimization of Language Models Derived from Unification Grammars

    Science.gov (United States)

    Rayner, Manny; Hockey, Beth Ann; James, Frankie; Bratt, Harry; Bratt, Elizabeth O.; Gawron, Mark; Goldwater, Sharon; Dowding, John; Bhagat, Amrita

    2000-01-01

    We describe a technique which makes it feasible to improve the performance of a language model derived from a manually constructed unification grammar, using low-quality untranscribed speech data and a minimum of human annotation. The method is on a medium-vocabulary spoken language command and control task.

  2. High Order Adjoint Derivatives using ESDIRK Methods for Oil Reservoir Production Optimization

    DEFF Research Database (Denmark)

    Capolei, Andrea; Stenby, Erling Halfdan; Jørgensen, John Bagterp

    2012-01-01

    In production optimization, computation of the gradients is the computationally expensive step. We improve the computational efficiency of such algorithms by improving the gradient computation using high-order ESDIRK (Explicit Singly Diagonally Implicit Runge-Kutta) temporal integration methods...... and continuous adjoints . The high order integration scheme allows larger time steps and therefore faster solution times. We compare gradient computation by the continuous adjoint method to the discrete adjoint method and the finite-difference method. The methods are implemented for a two phase flow reservoir...... the time steps are controlled in a certain range, the continuous adjoint method produces gradients sufficiently accurate for the optimization algorithm and somewhat faster than the discrete adjoint method....

  3. Optimization

    CERN Document Server

    Pearce, Charles

    2009-01-01

    Focuses on mathematical structure, and on real-world applications. This book includes developments in several optimization-related topics such as decision theory, linear programming, turnpike theory, duality theory, convex analysis, and queuing theory.

  4. An optimal estimation algorithm to derive Ice and Ocean parameters from AMSR Microwave radiometer observations

    DEFF Research Database (Denmark)

    Pedersen, Leif Toudal; Tonboe, Rasmus T.; Høyer, Jacob

    robin reference dataset. Over open water the reference data is a co-location of satellite SST, ERA Interim re-analysis data and observed brightness temperatures. Over ice the reference data is a co-location of ERA Interim re-analysis data, and observed AMSR microwave brightness temperatures. Due...... to the nonlinearity of the radiative transfer equation we need an iterative approach to obtain the optimal estimate. The paper will demonstrate results of retrievals of SST and Sea Ice Concentration....

  5. Structural Investigation for Optimization of Anthranilic Acid Derivatives as Partial FXR Agonists by in Silico Approaches

    Directory of Open Access Journals (Sweden)

    Meimei Chen

    2016-04-01

    Full Text Available In this paper, a three level in silico approach was applied to investigate some important structural and physicochemical aspects of a series of anthranilic acid derivatives (AAD newly identified as potent partial farnesoid X receptor (FXR agonists. Initially, both two and three-dimensional quantitative structure activity relationship (2D- and 3D-QSAR studies were performed based on such AAD by a stepwise technology combined with multiple linear regression and comparative molecular field analysis. The obtained 2D-QSAR model gave a high predictive ability (R2train = 0.935, R2test = 0.902, Q2LOO = 0.899. It also uncovered that number of rotatable single bonds (b_rotN, relative negative partial charges (RPC−, oprea's lead-like (opr_leadlike, subdivided van der Waal’s surface area (SlogP_VSA2 and accessible surface area (ASA were important features in defining activity. Additionally, the derived3D-QSAR model presented a higher predictive ability (R2train = 0.944, R2test = 0.892, Q2LOO = 0.802. Meanwhile, the derived contour maps from the 3D-QSAR model revealed the significant structural features (steric and electronic effects required for improving FXR agonist activity. Finally, nine newly designed AAD with higher predicted EC50 values than the known template compound were docked into the FXR active site. The excellent molecular binding patterns of these molecules also suggested that they can be robust and potent partial FXR agonists in agreement with the QSAR results. Overall, these derived models may help to identify and design novel AAD with better FXR agonist activity.

  6. Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors.

    Science.gov (United States)

    Ramachandran, Sreekanth A; Jadhavar, Pradeep S; Miglani, Sandeep K; Singh, Manvendra P; Kalane, Deepak P; Agarwal, Anil K; Sathe, Balaji D; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J; Rai, Roopa

    2017-05-15

    Signaling via the receptor tyrosine kinase CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). TAMs play pro-tumorigenic roles, including the suppression of anti-tumor immune response, promotion of angiogenesis and tumor cell metastasis. Because of the role of this signaling pathway in the tumor microenvironment, several small molecule CSF1R kinase inhibitors are undergoing clinical evaluation for cancer therapy, either as a single agent or in combination with other cancer therapies, including immune checkpoint inhibitors. Herein we describe our lead optimization effort that resulted in the identification of a potent, cellular active and orally bioavailable bis-amide CSF1R inhibitor. Docking and biochemical analysis allowed the removal of a metabolically labile and poorly permeable methyl piperazine group from an early lead compound. Optimization led to improved metabolic stability and Caco2 permeability, which in turn resulted in good oral bioavailability in mice. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Epoxidation of methyl esters derived from Jatropha oil: An optimization study

    Energy Technology Data Exchange (ETDEWEB)

    Mushtaq, M.; Tan, I. M.; Nadeem, M.; Devi, C.; Lee, S. Y. C.; Sagir, M.; Radhid, U.

    2013-05-01

    The optimization of the epoxidation reaction of methyl esters obtained from Jatropha oil was appraised. Response surface methodology (RSM) based on a central composite rotatable design (CCRD) was employed for the experimental design. Four reaction variables namely hydrogen peroxide/ C=C mole ratio, formic acid/C=C mole ratio, reaction temperature and reaction time were evaluated. The optimum epoxidation conditions calculated by the quadratic model were 3.12 moles of hydrogen peroxide/C=C moles, 0.96 moles of formic acid/C=C moles, a reaction temperature of 70.0 degree centigrade and a reaction time of 277 minutes. A reaction optimized by the proposed process parameters provided a yield of 92.89 {+-} 1.29 wt.% with relatively improved reaction time. Hydrogen peroxide concentration and reaction temperature were found to be the most significant variables while reaction temperature and hydrogen peroxide showed strong interactions. The epoxidized methyl esters were analyzed using FT-IR, 1H NMR and {sup 1}3C NMR techniques. This study suggested relatively higher molar ratio of formic acid required than was proposed in the literature. (Author) 33 refs.

  8. Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development.

    Directory of Open Access Journals (Sweden)

    Ville Härmä

    Full Text Available The anti-invasive and anti-proliferative effects of betulins and abietane derivatives was systematically tested using an organotypic model system of advanced, castration-resistant prostate cancers. A preliminary screen of the initial set of 93 compounds was performed in two-dimensional (2D growth conditions using non-transformed prostate epithelial cells (EP156T, an androgen-sensitive prostate cancer cell line (LNCaP, and the castration-resistant, highly invasive cell line PC-3. The 25 most promising compounds were all betulin derivatives. These were selected for a focused secondary screen in three-dimensional (3D growth conditions, with the goal to identify the most effective and specific anti-invasive compounds. Additional sensitivity and cytotoxicity tests were then performed using an extended cell line panel. The effects of these compounds on cell cycle progression, mitosis, proliferation and unspecific cytotoxicity, versus their ability to specifically interfere with cell motility and tumor cell invasion was addressed. To identify potential mechanisms of action and likely compound targets, multiplex profiling of compound effects on a panel of 43 human protein kinases was performed. These target de-convolution studies, combined with the phenotypic analyses of multicellular organoids in 3D models, revealed specific inhibition of AKT signaling linked to effects on the organization of the actin cytoskeleton as the most likely driver of altered cell morphology and motility.

  9. Production and Optimization of Direct Coal Liquefaction derived Low Carbon-Footprint Transportation Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Steven Markovich

    2010-06-30

    This report summarizes works conducted under DOE Contract No. DE-FC26-05NT42448. The work scope was divided into two categories - (a) experimental program to pretreat and refine a coal derived syncrude sample to meet transportation fuels requirements; (b) system analysis of a commercial scale direct coal liquefaction facility. The coal syncrude was derived from a bituminous coal by Headwaters CTL, while the refining study was carried out under a subcontract to Axens North America. The system analysis included H{sub 2} production cost via six different options, conceptual process design, utilities requirements, CO{sub 2} emission and overall plant economy. As part of the system analysis, impact of various H{sub 2} production options was evaluated. For consistence the comparison was carried out using the DOE H2A model. However, assumptions in the model were updated using Headwaters database. Results of Tier 2 jet fuel specifications evaluation by the Fuels & Energy Branch, US Air Force Research Laboratory (AFRL/RZPF) located at Wright Patterson Air Force Base (Ohio) are also discussed in this report.

  10. Design, analysis and optimization of switched-capacitor filters derived from lumped analog models

    Science.gov (United States)

    Haug, K.

    1981-08-01

    The considered investigation makes use of the signal flow graph (SFG) procedure developed by Brodersen et al. (1979). This approach is employed in connection with the low sensitivity of the transfer function against parameter variations and the small effect of stray capacitances inherent in the SFG procedure. The design of switched-capacitor (SC) filters is illustrated with the aid of an example, involving a fifth degree PCM low-pass filter. The purpose of the design procedure is to obtain a filter structure whose frequency determining elements are integrators. Attention is given to the reduction of the distortion caused by the additional delay, the application of a design centering procedure for eliminating distortion, the optimization of the dynamic range, and parasitic effects.

  11. The utility of an empirically derived co-activation ratio for muscle force prediction through optimization.

    Science.gov (United States)

    Brookham, Rebecca L; Middlebrook, Erin E; Grewal, Tej-jaskirat; Dickerson, Clark R

    2011-05-17

    Biomechanical optimization models that apply efficiency-based objective functions often underestimate or negate antagonist co-activation. Co-activation assists movement control, joint stabilization and limb stiffness and should be carefully incorporated into models. The purposes of this study were to mathematically describe co-activation relationships between elbow flexors and extensors during isometric exertions at varying intensity levels and postures, and secondly, to apply these co-activation relationships as constraints in an optimization muscle force prediction model of the elbow and assess changes in predictions made while including these constraints. Sixteen individuals performed 72 isometric exertions while holding a load in their right hand. Surface EMG was recorded from elbow flexors and extensors. A co-activation index provided a relative measure of flexor contribution to total activation about the elbow. Parsimonious models of co-activation during flexion and extension exertions were developed and added as constraints to a muscle force prediction model to enforce co-activation. Three different PCSA data sets were used. Elbow co-activation was sensitive to changes in posture and load. During flexion exertions the elbow flexors were activated about 75% MVC (this amount varied according to elbow angle, shoulder flexion and abduction angles, and load). During extension exertions the elbow flexors were activated about 11% MVC (this amount varied according to elbow angle, shoulder flexion angle and load). The larger PCSA values appeared to be more representative of the subject pool. Inclusion of these co-activation constraints improved the model predictions, bringing them closer to the empirically measured activation levels. Copyright © 2011 Elsevier Ltd. All rights reserved.

  12. New scale-down methodology from commercial to lab scale to optimize plant-derived soft gel capsule formulations on a commercial scale.

    Science.gov (United States)

    Oishi, Sana; Kimura, Shin-Ichiro; Noguchi, Shuji; Kondo, Mio; Kondo, Yosuke; Shimokawa, Yoshiyuki; Iwao, Yasunori; Itai, Shigeru

    2018-01-15

    A new scale-down methodology from commercial rotary die scale to laboratory scale was developed to optimize a plant-derived soft gel capsule formulation and eventually manufacture superior soft gel capsules on a commercial scale, in order to reduce the time and cost for formulation development. Animal-derived and plant-derived soft gel film sheets were prepared using an applicator on a laboratory scale and their physicochemical properties, such as tensile strength, Young's modulus, and adhesive strength, were evaluated. The tensile strength of the animal-derived and plant-derived soft gel film sheets was 11.7 MPa and 4.41 MPa, respectively. The Young's modulus of the animal-derived and plant-derived soft gel film sheets was 169 MPa and 17.8 MPa, respectively, and both sheets showed a similar adhesion strength of approximately 4.5-10 MPa. Using a D-optimal mixture design, plant-derived soft gel film sheets were prepared and optimized by varying their composition, including variations in the mass of κ-carrageenan, ι-carrageenan, oxidized starch and heat-treated starch. The physicochemical properties of the sheets were evaluated to determine the optimal formulation. Finally, plant-derived soft gel capsules were manufactured using the rotary die method and the prepared soft gel capsules showed equivalent or superior physical properties compared with pre-existing soft gel capsules. Therefore, we successfully developed a new scale-down methodology to optimize the formulation of plant-derived soft gel capsules on a commercial scale. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Toward efficient photomodulation of conjugated polymer emission: optimizing differential energy transfer in azobenzene-substituted PPV derivatives.

    Science.gov (United States)

    Grimes, Amy F; Call, Scott E; Vicente, Diego A; English, Douglas S; Harbron, Elizabeth J

    2006-10-05

    We present fluorescence studies of quenching behavior in photoaddressable azobenzene-substituted derivatives of the fluorescent conjugated polymer poly(p-phenylenevinylene) (PPV). The azobenzene side chains partially quench the PPV fluorescence, and we have shown previously that the quenching efficiency is greater when the azobenzene side chains are cis than when they are trans. This effect provides a photoaddressable means of modulating the fluorescence intensity of PPV derivatives. To optimize the efficiency of photoinduced intensity modulation, it is important to understand the molecular nature of quenching by both trans- and cis-azobenzene side chains. Here we investigate the photophysical origins of quenching by the two isomers using steady-state and time-resolved fluorescence spectroscopy. We present results from the azobenzene-modified PPV derivative poly(2-methoxy-5-((10-(4-(phenylazo)phenoxy)decyl)oxy)-1,4-phenylenevinylene) (MPA-10-PPV) and two new related polymers, a copolymer lacking half of the azobenzene side chains and an analogue of MPA-10-PPV with a tert-butyl-substituted azobenzene. These studies reveal that steric interactions influence the extent of PPV emission quenching by trans-azobenzene but do not affect the efficient quenching by cis-azobenzene. The difference in dynamic quenching efficiencies between trans- and cis-azobenzene isomers is consistent with fluorescence resonance energy transfer. These results show that it is possible to control the efficiency of photoswitchable fluorescence modulation through specific structural variations designed to encourage or block quenching by trans-azobenzene. This is a promising approach to providing useful general guidelines for designing photomodulated PPV derivatives.

  14. OPTIMIZATION OF TIME REACTION AND HYDROXIDE ION CONCENTRATION ON FLAVONOID SYNTHESIS FROM BENZALDEHYDE AND ITS DERIVATIVES

    Directory of Open Access Journals (Sweden)

    Sri Handayani

    2010-06-01

    Full Text Available The aim of this research is to determine the optimum time of reaction and concentration of hydroxide ion on chalcone, 4-methoxychalcone and 3,4-dimethoxychalcone synthesis. Chalcone and its derivatives were synthesized by dissolving KOH in ethanol followed by dropwise addition of acetophenone and benzaldehyde. Then, the mixture was stirred for several hours. Three benzaldehydes has been used, i.e : benzaldehyde, p-anysaldehyde and veratraldehyde. The time of reaction was varied for, 12, 18, 24, 30 and 36 hours. Furthermore, on the optimum reaction time for each benzaldehyde the hydroxyl ion concentration was varied from 5,7,9,11 and 13%(w/v. The results of this research suggested that the optimum time of chalchone synthesis was 12 hours, while, 4-methoxychalcone and 3,4-dimethoxychalcone were 30 hours. The optimum concentration of hydroxide ion of chalcone synthesis was 13% and for 4-methoxychalcone and 3,4-dimethoxychalcone were 11%. Keywords: Chalcone synthesis, time of reaction, hydroxide ion concentration.

  15. A role for maternally derived myokines to optimize placental function and fetal growth across gestation.

    Science.gov (United States)

    Dubé, Chantal; Aguer, Céline; Adamo, Kristi; Bainbridge, Shannon

    2017-05-01

    Exercise during pregnancy is associated with improved health outcomes for both mother and baby, including a reduced risk of future obesity and susceptibility to chronic diseases. Overwhelming evidence demonstrates a protective effect of maternal exercise against fetal birth weight extremes, reducing the rates of both large- and small-for-gestational-age infants. It is speculated that this protective effect is mediated in part through exercise-induced regulation of maternal physiology and placental development and function. However, the specific mechanisms through which maternal exercise regulates these changes remain to be discovered. We hypothesize that myokines, a collection of peptides and cytokines secreted from contracting skeletal muscles during exercise, may be an important missing link in the story. Myokines are known to reduce inflammation, improve metabolism and enhance macronutrient transporter expression and activity in various tissues of nonpregnant individuals. Little research to date has focused on the specific roles of the myokine secretome in the context of pregnancy; however, it is likely that myokines secreted from exercising skeletal muscles may modulate the maternal milieu and directly impact the vital organ of pregnancy-the placenta. In the current review, data in strong support of this potential role of myokines will be presented, suggesting myokine secretion as a key mechanism through which maternal exercise optimizes fetal growth trajectories. It is clear that further research is warranted in this area, as knowledge of the biological roles of myokines in the context of pregnancy would better inform clinical recommendations for exercise during pregnancy and contribute to the development of important therapeutic interventions.

  16. DE optimized fuzzy PID controller with derivative filter for LFC of multi source power system in deregulated environme

    Directory of Open Access Journals (Sweden)

    Rabindra Kumar Sahu

    2015-06-01

    Full Text Available In this paper, Differential Evolution (DE optimized fuzzy PID controller with derivative Filter (PIDF is proposed for Load Frequency Control (LFC of a deregulated power system with multi-source power generation and interconnected via parallel AC/DC transmission links. To get an accurate insight of the LFC problem, important physical constraints such as time delay and GRC are considered. The performance of proposed controller is evaluated at all possible power transactions that take place in a deregulated power market. The improvement in dynamic performance of the power system with DC link in parallel with AC tie-line is also assessed. Further, sensitivity analysis is performed by varying the system parameters and operating load conditions from their nominal values. It is observed from the simulation results that the optimum gains of the proposed controller need not be reset even if the system is subjected to wide variation in loading condition and system parameters.

  17. Carbide-Derived Carbons with Tunable Porosity Optimized for Hydrogen Storage

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, John E.; Gogotsi, Yury; Yildirim, Taner

    2010-01-07

    On-board hydrogen storage is a key requirement for fuel cell-powered cars and trucks. Porous carbon-based materials can in principle adsorb more hydrogen per unit weight at room temperature than liquid hydrogen at -176 oC. Achieving this goal requires interconnected pores with very high internal surface area, and binding energies between hydrogen and carbon significantly enhanced relative to H2 on graphite. In this project a systematic study of carbide-derived carbons, a novel form of porous carbon, was carried out to discover a high-performance hydrogen sorption material to meet the goal. In the event we were unable to improve on the state of the art in terms of stored hydrogen per unit weight, having encountered the same fundamental limit of all porous carbons: the very weak interaction between H2 and the carbon surface. On the other hand we did discover several strategies to improve storage capacity on a volume basis, which should be applicable to other forms of porous carbon. Further discoveries with potentially broader impacts include • Proof that storage performance is not directly related to pore surface area, as had been previously claimed. Small pores (< 1.5 nm) are much more effective in storing hydrogen than larger ones, such that many materials with large total surface areas are sub-par performers. • Established that the distribution of pore sizes can be controlled during CDC synthesis, which opens the possibility of developing high performance materials within a common family while targeting widely disparate applications. Examples being actively pursued with other funding sources include methane storage, electrode materials for batteries and supercapacitors with record high specific capacitance, and perm-selective membranes which bind cytokines for control of infections and possibly hemodialysis filters.

  18. Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives.

    Science.gov (United States)

    Flegg, Jennifer A; Guérin, Philippe J; Nosten, Francois; Ashley, Elizabeth A; Phyo, Aung Pyae; Dondorp, Arjen M; Fairhurst, Rick M; Socheat, Duong; Borrmann, Steffen; Björkman, Anders; Mårtensson, Andreas; Mayxay, Mayfong; Newton, Paul N; Bethell, Delia; Se, Youry; Noedl, Harald; Diakite, Mahamadou; Djimde, Abdoulaye A; Hien, Tran T; White, Nicholas J; Stepniewska, Kasia

    2013-11-13

    The emergence of Plasmodium falciparum resistance to artemisinins in Southeast Asia threatens the control of malaria worldwide. The pharmacodynamic hallmark of artemisinin derivatives is rapid parasite clearance (a short parasite half-life), therefore, the in vivo phenotype of slow clearance defines the reduced susceptibility to the drug. Measurement of parasite counts every six hours during the first three days after treatment have been recommended to measure the parasite clearance half-life, but it remains unclear whether simpler sampling intervals and frequencies might also be sufficient to reliably estimate this parameter. A total of 2,746 parasite density-time profiles were selected from 13 clinical trials in Thailand, Cambodia, Mali, Vietnam, and Kenya. In these studies, parasite densities were measured every six hours until negative after treatment with an artemisinin derivative (alone or in combination with a partner drug). The WWARN Parasite Clearance Estimator (PCE) tool was used to estimate "reference" half-lives from these six-hourly measurements. The effect of four alternative sampling schedules on half-life estimation was investigated, and compared to the reference half-life (time zero, 6, 12, 24 (A1); zero, 6, 18, 24 (A2); zero, 12, 18, 24 (A3) or zero, 12, 24 (A4) hours and then every 12 hours). Statistical bootstrap methods were used to estimate the sampling distribution of half-lives for parasite populations with different geometric mean half-lives. A simulation study was performed to investigate a suite of 16 potential alternative schedules and half-life estimates generated by each of the schedules were compared to the "true" half-life. The candidate schedules in the simulation study included (among others) six-hourly sampling, schedule A1, schedule A4, and a convenience sampling schedule at six, seven, 24, 25, 48 and 49 hours. The median (range) parasite half-life for all clinical studies combined was 3.1 (0.7-12.9) hours. Schedule A1

  19. Kinetics and Optimization of Lipophilic Kojic Acid Derivative Synthesis in Polar Aprotic Solvent Using Lipozyme RMIM and Its Rheological Study

    Directory of Open Access Journals (Sweden)

    Nurazwa Ishak

    2018-02-01

    Full Text Available The synthesis of kojic acid derivative (KAD from kojic and palmitic acid (C16:0 in the presence of immobilized lipase from Rhizomucor miehei (commercially known as Lipozyme RMIM, was studied using a shake flask system. Kojic acid is a polyfunctional heterocycles that acts as a source of nucleophile in this reaction allowing the formation of a lipophilic KAD. In this study, the source of biocatalyst, Lipozyme RMIM, was derived from the lipase of Rhizomucor miehei immobilized on weak anion exchange macro-porous Duolite ES 562 by the adsorption technique. The effects of solvents, enzyme loading, reaction temperature, and substrate molar ratio on the reaction rate were investigated. In one-factor-at-a-time (OFAT experiments, a high reaction rate (30.6 × 10−3 M·min−1 of KAD synthesis was recorded using acetone, enzyme loading of 1.25% (w/v, reaction time of 12 h, temperature of 50 °C and substrate molar ratio of 5:1. Thereafter, a yield of KAD synthesis was optimized via the response surface methodology (RSM whereby the optimized molar ratio (fatty acid: kojic acid, enzyme loading, reaction temperature and reaction time were 6.74, 1.97% (w/v, 45.9 °C, and 20 h respectively, giving a high yield of KAD (64.47%. This condition was reevaluated in a 0.5 L stirred tank reactor (STR where the agitation effects of two impellers; Rushton turbine (RT and pitch-blade turbine (PBT, were investigated. In the STR, a very high yield of KAD synthesis (84.12% was achieved using RT at 250 rpm, which was higher than the shake flask, thus indicating better mixing quality in STR. In a rheological study, a pseudoplastic behavior of KAD mixture was proposed for potential application in lotion formulation.

  20. Kinetics and Optimization of Lipophilic Kojic Acid Derivative Synthesis in Polar Aprotic Solvent Using Lipozyme RMIM and Its Rheological Study.

    Science.gov (United States)

    Ishak, Nurazwa; Lajis, Ahmad Firdaus B; Mohamad, Rosfarizan; Ariff, Arbakariya B; Mohamed, Mohd Shamzi; Halim, Murni; Wasoh, Helmi

    2018-02-24

    The synthesis of kojic acid derivative (KAD) from kojic and palmitic acid (C16:0) in the presence of immobilized lipase from Rhizomucor miehei (commercially known as Lipozyme RMIM), was studied using a shake flask system. Kojic acid is a polyfunctional heterocycles that acts as a source of nucleophile in this reaction allowing the formation of a lipophilic KAD. In this study, the source of biocatalyst, Lipozyme RMIM, was derived from the lipase of Rhizomucor miehei immobilized on weak anion exchange macro-porous Duolite ES 562 by the adsorption technique. The effects of solvents, enzyme loading, reaction temperature, and substrate molar ratio on the reaction rate were investigated. In one-factor-at-a-time (OFAT) experiments, a high reaction rate (30.6 × 10 -3 M·min -1 ) of KAD synthesis was recorded using acetone, enzyme loading of 1.25% ( w / v ), reaction time of 12 h, temperature of 50 °C and substrate molar ratio of 5:1. Thereafter, a yield of KAD synthesis was optimized via the response surface methodology (RSM) whereby the optimized molar ratio (fatty acid: kojic acid), enzyme loading, reaction temperature and reaction time were 6.74, 1.97% ( w / v ), 45.9 °C, and 20 h respectively, giving a high yield of KAD (64.47%). This condition was reevaluated in a 0.5 L stirred tank reactor (STR) where the agitation effects of two impellers; Rushton turbine (RT) and pitch-blade turbine (PBT), were investigated. In the STR, a very high yield of KAD synthesis (84.12%) was achieved using RT at 250 rpm, which was higher than the shake flask, thus indicating better mixing quality in STR. In a rheological study, a pseudoplastic behavior of KAD mixture was proposed for potential application in lotion formulation.

  1. Optimized Methods to Explore the Mechanistic and Biomarker Potential of Hepatocyte-Derived Exosomes in Drug-Induced Liver Injury.

    Science.gov (United States)

    Thacker, Sarah E; Nautiyal, Manisha; Otieno, Monicah A; Watkins, Paul B; Mosedale, Merrie

    2018-01-27

    Recent evidence supports that alterations in hepatocyte-derived exosomes (HDE) may play a role in the pathogenesis of drug-induced liver injury (DILI). HDE-based biomarkers also hold promise to improve the sensitivity of existing in vitro assays for predicting DILI liability. Primary human hepatocytes (PHH) provide a physiologically relevant in vitro model to explore the mechanistic and biomarker potential of HDE in DILI. However, optimal methods to study exosomes in this culture system have not been defined. Here we use HepG2 and HepaRG cells along with PHH to optimize methods for in vitro HDE research. We compared the quantity and purity of HDE enriched from HepG2 cell culture medium by three widely used methods: ultracentrifugation (UC), OptiPrep density gradient ultracentrifugation (ODG), and ExoQuick (EQ) - a commercially available exosome precipitation reagent. While EQ resulted in the highest number of particles, UC resulted in more exosomes as indicated by the relative abundance of exosomal CD63 to cellular prohibitin-1 as well as the comparative absence of contaminating extravesicular material. To determine culture conditions that best supported exosome release, we also assessed the effect of Matrigel matrix overlay at concentrations ranging from 0-0.25 mg/ml in HepaRG cells and compared exosome release from fresh and cryopreserved PHH from same donor. Sandwich culture did not impair exosome release, and freshly prepared PHH yielded a higher number of HDE overall. Taken together, our data support the use of UC-based enrichment from fresh preparations of sandwich-cultured PHH for future studies of HDE in DILI. © The Author 2018. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  2. In vitro detection of contact allergens: development of an optimized protocol using human peripheral blood monocyte-derived dendritic cells.

    Science.gov (United States)

    Reuter, Hendrik; Spieker, Jochem; Gerlach, Silke; Engels, Ursula; Pape, Wolfgang; Kolbe, Ludger; Schmucker, Robert; Wenck, Horst; Diembeck, Walter; Wittern, Klaus-Peter; Reisinger, Kerstin; Schepky, Andreas G

    2011-02-01

    Allergic contact dermatitis is a delayed T-cell mediated allergic response associated with relevant social and economic impacts. Animal experiments (e.g. the local lymph node assay) are still supplying most of the data used to assess the sensitization potential of new chemicals. However, the 7th amendment to the EU Cosmetic Directive will introduce a testing ban for cosmetic ingredients after 2013. In vitro alternative methods are thus being actively developed. Although promising results have been obtained with cell lines, their reduced functionality and inherent genomic instability led us to reinvestigate the use of peripheral blood monocyte-derived dendritic cells (PBMDCs) for the establishment of a reliable in vitro sensitization test. To solve the issues associated with the use of primary cells, the culture and exposure conditions (cytokine concentrations, incubation time, readout, pooled vs. single donors and cytotoxicity) were re-assessed and optimized. Here we propose a stable and reproducible protocol based on PBMDCs. This should allow a wider acceptance of PBMDCs as a reliable test system for the detection of human skin sensitizers and the inclusion of this protocol in an integrated testing strategy. Copyright © 2010 Elsevier Ltd. All rights reserved.

  3. A New Method for Deriving Robust and Globalized Robust Solutions of Uncertain Linear Conic Optimization Problems Having General Convex Uncertainty Sets

    NARCIS (Netherlands)

    Gorissen, B.L.; Ben-Tal, A.; Blanc, J.P.C.; den Hertog, D.

    2012-01-01

    Abstract: We propose a new way to derive tractable robust counterparts of a linear conic optimization problem by using the theory of Beck and Ben-Tal [2] on the duality between the robust (“pessimistic”) primal problem and its “optimistic” dual. First, we obtain a new convex reformulation of the

  4. In silico engineering and optimization of Transcription Activator-Like Effectors and their derivatives for improved DNA binding predictions.

    KAUST Repository

    Piatek, Marek J.

    2015-12-01

    Transcription Activator-Like Effectors (TALEs) can be used as adaptable DNAbinding modules to create site-specific chimeric nucleases or synthetic transcriptional regulators. The central repeat domain mediates specific DNA binding via hypervariable repeat di-residues (RVDs). This DNA-Binding Domain can be engineered to bind preferentially to any user-selected DNA sequence if engineered appropriately. Therefore, TALEs and their derivatives have become indispensable molecular tools in site-specific manipulation of genes and genomes. This thesis revolves around two problems: in silico design and improved binding site prediction of TALEs. In the first part, a study is shown where TALEs are successfully designed in silico and validated in laboratory to yield the anticipated effects on selected genes. Software is developed to accompany the process of designing and prediction of binding sites. I expanded the functionality of the software to be used as a more generic set of tools for the design, target and offtarget searching. Part two contributes a method and associated toolkit developed to allow users to design in silico optimized synthetic TALEs with user-defined specificities for various experimental purposes. This method is based on a mutual relationship of three consecutive tandem repeats in the DNA-binding domain. This approach revealed positional and compositional bias behind the binding of TALEs to DNA. In conclusion, I developed methods, approaches, and software to enhance the functionality of synthetic TALEs, which should improve understanding of TALEs biology and will further advance genome-engineering applications in various organisms and cell types.

  5. Dynamics of vanishing of maternally derived antibodies of Ungulate protoparvovirus 1 suggests an optimal age for gilts vaccination.

    Science.gov (United States)

    Gava, Danielle; Souza, Carine Kunzler; Mores, Tiago José; Argenti, Laura Espíndola; Streck, André Felipe; Canal, Cláudio Wageck; Bortolozzo, Fernando Pandolfo; Wentz, Ivo

    2017-06-01

    The prevention of Ungulate protoparvovirus 1 (UPV1) infection and consequently the reproductive losses is based on vaccination of all pigs intended for breeding. As maternally derived antibodies (MDA) can interfere with the development of immunity following vaccination, it is important to know the duration of anti-UPV1 MDA to determine the optimal age for the best vaccination efficacy. To elucidate the association between dam and piglet antibody levels against UPV1 and to estimate the decrease rate of MDA, sera and colostrum of 127 gilts (before the first vaccination against UPV1; 15 days after the second vaccine dose; at farrowing; and during the second pregnancy) and sera of 276 piglets (prior to initial colostrum intake; at 7, 21, 57, 87, and 128 days-old) were tested by ELISA. Most gilts (85.8%) had anti-UPV1 antibodies before vaccination and after vaccination all were positive. At 7 days old, the majority of the piglets had anti-UPV1 antibodies, but around 57 days old, only 35.3% were positive and at 87 days old, all were negative. The estimated average half-life of MDA was 29.8 (28.8-30.9) days. A strong correlation was determined between piglet serum at 7 days old with gilt serum at farrowing time (r = 0.77, n = 248, P < 0.001) and with piglet serum at 7 days old with colostrum (r = 0.73, n = 248, P < 0.001). The MDA decreased earlier and the antibody half-life was a little longer than previously reported. Based on these findings, UPV1 vaccination can be performed earlier than usual.

  6. Benzyl derivatives with in vitro binding affinity for human opioid and cannabinoid receptors from the fungus Eurotium repens.

    Science.gov (United States)

    Gao, Jiangtao; León, Francisco; Radwan, Mohamed M; Dale, Olivia R; Husni, Afeef S; Manly, Susan P; Lupien, Shari; Wang, Xiaoning; Hill, Robert A; Dugan, Frank M; Cutler, Horace G; Cutler, Stephen J

    2011-07-22

    Bioassay-guided fractionation of the fungus Eurotium repens resulted in the isolation of two new benzyl derivatives, (E)-2-(hept-1-enyl)-3-(hydroxymethyl)-5-(3-methylbut-2-enyl)benzene-1,4-diol (1) and (E)-4-(hept-1-enyl)-7-(3-methylbut-2-enyl)-2,3-dihydrobenzofuran-2,5-diol (2), along with seven known compounds (3-9) including five benzaldehyde compounds, flavoglaucin (3), tetrahydroauroglaucin (4), dihydroauroglaucin (5), auroglaucin (6), and 2-(2',3-epoxy-1',3'- heptadienyl)-6-hydroxy-5-(3-methyl-2-butenyl)benzaldehyde (7), one diketopiperazine alkaloid, echinulin (8), and 5,7-dihydroxy-4-methylphthalide (9). The chemical structures of these compounds were established on the basis of extensive 1D and 2D NMR and HRMS data. Compounds 1-4 and 6 showed good binding affinity for human opioid or cannabinoid receptors. These findings have important implications for psychoactive studies with this class of compounds.

  7. EEG evidence for shunt requirement during carotid endarterectomy: optimal EEG derivations with respect to frequency bands and anesthetic regimen.

    NARCIS (Netherlands)

    Laman, D.M.; Reijden, C.S. van der; Wieneke, G.H.; Duijn, H. van; Huffelen, A.C. van

    2001-01-01

    Currently there is no consensus on the derivations that should be used for EEG monitoring during carotid endarterectomy (CEA). The aim of this study was to determine which derivations distinguish the best between patients requiring a shunt and patients who do not need a shunt. Four predefined

  8. Atropisomerism at C ̶ N bonds: Structural conformations and vibrational spectral study of Iminothiazoline Derivatives with density functional theoretical optimizations

    Directory of Open Access Journals (Sweden)

    F.Z. MIMOUNI

    2013-03-01

    Full Text Available The isolation of the pair atropisomers of the both iminothiazoline derivatives and the spectroscopic analytical of the compound have been computed using B3LYP/6-31G(d,p level to derive the equilibrium geometry, conformational stability, molecular orbital energies and vibrational frequencies was studied in this paper.

  9. Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria

    Directory of Open Access Journals (Sweden)

    Jamsen Kris M

    2012-07-01

    Full Text Available Abstract Background Artemisinin-based combination therapy (ACT is currently recommended as first-line treatment for uncomplicated malaria, but of concern, it has been observed that the effectiveness of the main artemisinin derivative, artesunate, has been diminished due to parasite resistance. This reduction in effect highlights the importance of the partner drugs in ACT and provides motivation to gain more knowledge of their pharmacokinetic (PK properties via population PK studies. Optimal design methodology has been developed for population PK studies, which analytically determines a sampling schedule that is clinically feasible and yields precise estimation of model parameters. In this work, optimal design methodology was used to determine sampling designs for typical future population PK studies of the partner drugs (mefloquine, lumefantrine, piperaquine and amodiaquine co-administered with artemisinin derivatives. Methods The optimal designs were determined using freely available software and were based on structural PK models from the literature and the key specifications of 100 patients with five samples per patient, with one sample taken on the seventh day of treatment. The derived optimal designs were then evaluated via a simulation-estimation procedure. Results For all partner drugs, designs consisting of two sampling schedules (50 patients per schedule with five samples per patient resulted in acceptable precision of the model parameter estimates. Conclusions The sampling schedules proposed in this paper should be considered in future population pharmacokinetic studies where intensive sampling over many days or weeks of follow-up is not possible due to either ethical, logistic or economical reasons.

  10. Derivation and validation of an HbA1c optimal cutoff for diagnosing prediabetes in a South African mixed ancestry population.

    Science.gov (United States)

    Zemlin, Annalise E; Matsha, Tandi E; Kengne, Andre P; Erasmus, Rajiv T

    2015-08-25

    Prediabetes compromises impaired fasting glucose and impaired glucose tolerance and is a high risk for future diabetes mellitus and cardiovascular disease. Traditional diagnostic methods involve a fasting sample or oral glucose tolerance test, which is cumbersome, time-consuming and inconvenient. An HbA1c-based approach has been incorporated into new guidelines, but cut-offs may vary and have not been defined for all population groups. We derived and validated HbA1c cut-offs to diagnose prediabetes in mixed ancestry South Africans. Participants were 667 (derivation sample), 234 (validation sample 1) and 674 (validation sample 2) diabetes-free individuals. They underwent standard 2-hour OGTT with HbA1c test. Receiver-operator characteristic curves were used to determine optimal HbA1c cut-off to predict prediabetes. A total of 27.7% participants in the derivation sample had prediabetes versus 17.5% (validation sample 1) and 15.4% (validation sample 2). The optimal cut-off was 5.75% in all three cohorts with sensitivity and specificity of 64.8% and 60.4% in combined derivation and validation sample 1, and 59.6% and 69.8% in validation sample 2. The discriminatory capacity of HbA1c for predicting prediabetes in this population is modest at the derived cut-off. The use of HbA1c alone in this setting may result in an inaccurate diagnosis. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. A System to Derive Optimal Tree Diameter Increment Models from the Eastwide Forest Inventory Data Base (EFIDB)

    Science.gov (United States)

    Don C. Bragg

    2002-01-01

    This article is an introduction to the computer software used by the Potential Relative Increment (PRI) approach to optimal tree diameter growth modeling. These DOS programs extract qualified tree and plot data from the Eastwide Forest Inventory Data Base (EFIDB), calculate relative tree increment, sort for the highest relative increments by diameter class, and...

  12. A new global fAPAR and LAI dataset derived from optimal albedo estimates: comparison with MODIS products

    OpenAIRE

    Mathias Disney; Jan-Peter Muller; Said Kharbouche; Thomas Kaminski; Michael Voßbeck; Philip Lewis; Bernard Pinty

    2016-01-01

    We present the first comparison between new fAPAR and LAI products derived from the GlobAlbedo dataset and the widely-used MODIS fAPAR and LAI and products. The GlobAlbedo derived products are produced using a 1D two-stream radiative transfer (RT) scheme designed explicitly for global parameter retrieval from albedo, with consistency between RT model assumptions and observations, as well as with typical large-scale land surface model RT schemes. The approach does not require biome-specifi...

  13. Optimal dietary lysine to threonine ratio in pigs (30-110 kg BW) derived from observed dietary amino acid efficiency.

    Science.gov (United States)

    Wecke, C; Liebert, F

    2010-12-01

    Optimal ratio of lysine (Lys) to threonine (Thr) in diets for growing barrows [genotype: Piétrain × (Large White × German Landrace)] was established at 30, 50, 70, 90 and 110 kg body weight (BW). N balance studies were conducted with diets based on constant mixture of wheat, barley, soybean meal and field peas. Supplementation of crystalline amino acids (AA) provided diets with Lys (diet A) and Thr (diet B) in first limiting position. For each BW range, totally 28 individual N balance data were utilized for assessing model parameters (exponential N utilization model) of dietary efficiency of Lys and Thr, respectively. Observed maximal dietary efficiency of Lys and Thr provided the database for conclusion of optimal dietary Lys to Thr ratio. Based on applied experimental conditions, BW dependent Lys to Thr ratio could not be concluded. On average, the dietary ratio Lys to Thr = 1:0.61 ± 0.02 was obtained as optimal for growing pigs. © 2010 The Authors. Journal of Animal Physiology and Animal Nutrition © 2010 Blackwell Verlag GmbH.

  14. An adaptive strategy on the error of the objective functions for uncertainty-based derivative-free optimization

    Science.gov (United States)

    Fusi, F.; Congedo, P. M.

    2016-03-01

    In this work, a strategy is developed to deal with the error affecting the objective functions in uncertainty-based optimization. We refer to the problems where the objective functions are the statistics of a quantity of interest computed by an uncertainty quantification technique that propagates some uncertainties of the input variables through the system under consideration. In real problems, the statistics are computed by a numerical method and therefore they are affected by a certain level of error, depending on the chosen accuracy. The errors on the objective function can be interpreted with the abstraction of a bounding box around the nominal estimation in the objective functions space. In addition, in some cases the uncertainty quantification methods providing the objective functions also supply the possibility of adaptive refinement to reduce the error bounding box. The novel method relies on the exchange of information between the outer loop based on the optimization algorithm and the inner uncertainty quantification loop. In particular, in the inner uncertainty quantification loop, a control is performed to decide whether a refinement of the bounding box for the current design is appropriate or not. In single-objective problems, the current bounding box is compared to the current optimal design. In multi-objective problems, the decision is based on the comparison of the error bounding box of the current design and the current Pareto front. With this strategy, fewer computations are made for clearly dominated solutions and an accurate estimate of the objective function is provided for the interesting, non-dominated solutions. The results presented in this work prove that the proposed method improves the efficiency of the global loop, while preserving the accuracy of the final Pareto front.

  15. Multiresponse optimization of a UPLC method for the simultaneous determination of tryptophan and 15 tryptophan-derived compounds using a Box-Behnken design with a desirability function.

    Science.gov (United States)

    Setyaningsih, Widiastuti; Saputro, Irfan E; Carrera, Ceferino A; Palma, Miguel; Barroso, Carmelo G

    2017-06-15

    A Box-Behnken design was used in conjunction with multiresponse optimization based on the desirability function to carry out the simultaneous separation of tryptophan and 15 derivatives by Ultra Performance Liquid Chromatography. The gradient composition of the mobile phase and the flow rate were optimized with respect to the resolution of severely overlapping chromatographic peaks and the total run time. Two different stationary phases were evaluated (hybrid silica and a solid-core-based C18 column). The methods were validated and a suitable sensitivity was found for all compounds in the concentration range 1-100μgL-1 (R2>0.999). High levels of repeatability and intermediate precision (CV less than 0.25% and 1.7% on average for the retention time and the signal area, respectively) were obtained. The new method was applied to the determination tryptophan and its derivatives in black pigmented glutinous and non-glutinous rice grain samples. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Simultaneous Learning and Filtering without Delusions: A Bayes-Optimal Derivation of Combining Predictive Inference and AdaptiveFiltering

    Directory of Open Access Journals (Sweden)

    Jan eKneissler

    2015-04-01

    Full Text Available Predictive coding appears to be one of the fundamental working principles of brain processing. Amongst other aspects, brains often predict the sensory consequences of their own actions. Predictive coding resembles Kalman filtering, where incoming sensory information is filtered to produce prediction errors for subsequent adaptation and learning. However, to generate prediction errors given motor commands, a suitable temporal forward model is required to generate predictions. While in engineering applications, it is usually assumed that this forward model is known, the brain has to learn it. When filtering sensory input and learning from the residual signal in parallel, a fundamental problem arises: the system can enter a delusional loop when filtering the sensory information using an overly trusted forward model. In this case, learning stalls before accurate convergence because uncertainty about the forward model is not properly accommodated. We present a Bayes-optimal solution to this generic and pernicious problem for the case of linear forward models, which we call Predictive Inference and Adaptive Filtering (PIAF. PIAF filters incoming sensory information and learns the forward model simultaneously. We show that PIAF is formally related to Kalman filtering and to the Recursive Least Squares linear approximation method, but combines these procedures in a Bayes optimal fashion. Numerical evaluations confirm that the delusional loop is precluded and that the learning of the forward model is more than ten-times faster when compared to a naive combination of Kalman filtering and Recursive Least Squares.

  17. Optimization of protocols for derivation of mouse embryonic stem cell lines from refractory strains, including the non obese diabetic mouse.

    Science.gov (United States)

    Davies, Timothy J; Fairchild, Paul J

    2012-07-01

    The derivation of pluripotent embryonic stem cells (ESCs) from a variety of genetic backgrounds remains a desirable objective in the generation of mice functionally deficient in genes of interest and the modeling of human disease. Nevertheless, disparity in the ease with which different strains of mice yield ESC lines has long been acknowledged. Indeed, the generation of bona fide ESCs from the non obese diabetic (NOD) mouse, a well-characterized model of human type I diabetes, has historically proved especially difficult to achieve. Here, we report the development of protocols for the derivation of novel ESC lines from C57Bl/6 mice based on the combined use of high concentrations of leukemia inhibitory factor and serum-replacement, which is equally applicable to fresh and cryo-preserved embryos. Further, we demonstrate the success of this approach using Balb/K and CBA/Ca mice, widely considered to be refractory strains. CBA/Ca ESCs contributed to the somatic germ layers of chimeras and displayed a very high competence at germline transmission. Importantly, we were able to use the same protocol for the derivation of ESC lines from nonpermissive NOD mice. These ESCs displayed a normal karyotype that was robustly stable during long-term culture, were capable of forming teratomas in vivo and germline competent chimeras after injection into recipient blastocysts. Further, these novel ESC lines efficiently formed embryoid bodies in vitro and could be directed in their differentiation along the dendritic cell lineage, thus illustrating their potential application to the generation of cell types of relevance to the pathogenesis of type I diabetes.

  18. An Efficient Power Regeneration and Drive Method of an Induction Motor by Means of an Optimal Torque Derived by Variational Method

    Science.gov (United States)

    Inoue, Kaoru; Ogata, Kenji; Kato, Toshiji

    When the motor speed is reduced by using a regenerative brake, the mechanical energy of rotation is converted to the electrical energy. When the regenerative torque is large, the corresponding current increases so that the copper loss also becomes large. On the other hand, the damping effect of rotation increases according to the time elapse when the regenerative torque is small. In order to use the limited energy effectively, an optimal regenerative torque should be discussed in order to regenerate electrical energy as much as possible. This paper proposes a design methodology of a regenerative torque for an induction motor to maximize the regenerative electric energy by means of the variational method. Similarly, an optimal torque for acceleration is derived in order to minimize the energy to drive. Finally, an efficient motor drive system with the proposed optimal torque and the power storage system stabilizing the DC link voltage will be proposed. The effectiveness of the proposed methods are illustrated by both simulations and experiments.

  19. An optimization study for radioiodination of a new synthesized benzamide derivative as an analogue tracer for malignant melanoma imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kandil, Shaban A.; Aglan, Hany; Seddik, Usama [Atomic Energy Authority, Cairo (Egypt). Nuclear Research Center; EL-Kafrawy, Ahmed F. [Ain Shams Univ., Cairo (Egypt). Faculty of Science

    2017-03-01

    Iodobenzamides are reported to possess some affinity for melanoma. This study describes the synthesis of a new benzamide analogue, N-(2-diethylamino-ethyl)-4-(4-chloro-nicotinamido)-5-[{sup 125}I]iodo-2 -methoxybenz amide ([{sup 125}I]H4) designed to target melanoma. The synthesis was simply achieved in four steps. There were two PyCIU/DIPEA amide condensations and a transfer hydrogenation using an ammonium formate hydrogen donor. The radioiodination step was carried out with {sup 125}I via an electrophilic substitution reaction. The reaction conditions were optimized. The labeled compound was purified by HPLC. The maximum radiochemical yield was found to be 78% at a radiochemical purity of 98%. All compounds were characterized by MS and NMR techniques. The log P value for [{sup 125}I]H4 was found as 3.96±0.5.

  20. Optimized extraction of daily bio-optical time series derived from MODIS/Aqua imagery for Lake Tanganyika, Africa

    DEFF Research Database (Denmark)

    Horion, Stéphanie; Bergamino, N; Stenuite, S

    2010-01-01

    Lake Tanganyika is one of the world's great freshwater ecosystems. In recent decades its hydrodynamic characteristics have undergone important changes that have had consequences on the lake's primary productivity. The establishment of a long-term Ocean Color dataset for Lake Tanganyika is a funda......Lake Tanganyika is one of the world's great freshwater ecosystems. In recent decades its hydrodynamic characteristics have undergone important changes that have had consequences on the lake's primary productivity. The establishment of a long-term Ocean Color dataset for Lake Tanganyika...... the MODIS-Aqua sensor. Standard MODIS Aqua Ocean Color products were found to not provide a suitable calibration for high altitude lakes such as the Lake Tanganyika. An optimization of the extraction process and the validation of the dataset were performed with independent sets of in situ measurements. Our...

  1. Assessing the weighted multi-objective adaptive surrogate model optimization to derive large-scale reservoir operating rules with sensitivity analysis

    Science.gov (United States)

    Zhang, Jingwen; Wang, Xu; Liu, Pan; Lei, Xiaohui; Li, Zejun; Gong, Wei; Duan, Qingyun; Wang, Hao

    2017-01-01

    The optimization of large-scale reservoir system is time-consuming due to its intrinsic characteristics of non-commensurable objectives and high dimensionality. One way to solve the problem is to employ an efficient multi-objective optimization algorithm in the derivation of large-scale reservoir operating rules. In this study, the Weighted Multi-Objective Adaptive Surrogate Model Optimization (WMO-ASMO) algorithm is used. It consists of three steps: (1) simplifying the large-scale reservoir operating rules by the aggregation-decomposition model, (2) identifying the most sensitive parameters through multivariate adaptive regression splines (MARS) for dimensional reduction, and (3) reducing computational cost and speeding the searching process by WMO-ASMO, embedded with weighted non-dominated sorting genetic algorithm II (WNSGAII). The intercomparison of non-dominated sorting genetic algorithm (NSGAII), WNSGAII and WMO-ASMO are conducted in the large-scale reservoir system of Xijiang river basin in China. Results indicate that: (1) WNSGAII surpasses NSGAII in the median of annual power generation, increased by 1.03% (from 523.29 to 528.67 billion kW h), and the median of ecological index, optimized by 3.87% (from 1.879 to 1.809) with 500 simulations, because of the weighted crowding distance and (2) WMO-ASMO outperforms NSGAII and WNSGAII in terms of better solutions (annual power generation (530.032 billion kW h) and ecological index (1.675)) with 1000 simulations and computational time reduced by 25% (from 10 h to 8 h) with 500 simulations. Therefore, the proposed method is proved to be more efficient and could provide better Pareto frontier.

  2. Discovery of a New Fungicide Candidate through Lead Optimization of Pyrimidinamine Derivatives and Its Activity against Cucumber Downy Mildew.

    Science.gov (United States)

    Guan, Aiying; Wang, Mingan; Yang, Jinlong; Wang, Lizeng; Xie, Yong; Lan, Jie; Liu, Changling

    2017-12-13

    Downy mildew is one of the most highly destructive of the diseases that cause damage to fruits and vegetables. Because of the continual development of resistance, it is important to discover new fungicides with different modes of action from existing fungicides for the control of downy mildew. This study is a continuation of our previous work on the novel pyrimidinamine lead compound, 9, and includes field trials for the identification of the optimal candidate. A new compound, 1c, was obtained, which gave a lower EC 50 value (0.10 mg/L) against downy mildew than lead compound 9 (0.19 mg/L) and the commercial fungicides diflumetorim, dimethomorph, and cyazofamid (1.01-23.06 mg/L). Compound 1c displayed similar broad-spectrum fungicidal activity to compound 9 but better field efficacy than compound 9, cyazofamid, and flumorph. The present work indicates that pyrimidinamine compound 1c is a candidate for further development as a commercial fungicide for the control of downy mildew.

  3. Defining Conditions for Optimal Inhibition of Food Intake in Rats by a Grape-Seed Derived Proanthocyanidin Extract

    Science.gov (United States)

    Serrano, Joan; Casanova-Martí, Àngela; Blay, Mayte; Terra, Ximena; Ardévol, Anna; Pinent, Montserrat

    2016-01-01

    Food intake depends on homeostatic and non-homeostatic factors. In order to use grape seed proanthocyanidins (GSPE) as food intake limiting agents, it is important to define the key characteristics of their bioactivity within this complex function. We treated rats with acute and chronic treatments of GSPE at different doses to identify the importance of eating patterns and GSPE dose and the mechanistic aspects of GSPE. GSPE-induced food intake inhibition must be reproduced under non-stressful conditions and with a stable and synchronized feeding pattern. A minimum dose of around 350 mg GSPE/kg body weight (BW) is needed. GSPE components act by activating the Glucagon-like peptide-1 (GLP-1) receptor because their effect is blocked by Exendin 9-39. GSPE in turn acts on the hypothalamic center of food intake control probably because of increased GLP-1 production in the intestine. To conclude, GSPE inhibits food intake through GLP-1 signaling, but it needs to be dosed under optimal conditions to exert this effect. PMID:27775601

  4. Optimal barn characteristics for high-yielding Holstein cows as derived by a new heat-stress model.

    Science.gov (United States)

    Shoshani, E; Hetzroni, A

    2013-01-01

    Meticulous planning is required to minimize heat-stress conditions in barns. The objective of this study was to determine optimum barn characteristics for high-yielding dairy cows under Israeli (Mediterranean) summer ambient conditions, by using a new stress model that takes ambient temperature, relative humidity and wind velocity into account. During the summers of 2004 and 2005, three meteorological stations were alternately installed in 39 barns: two stations inside the barn at the prevailing downwind direction, and a third station outside the upwind end of the barn. Ambient temperature, relative humidity, wind speed and direction were measured and recorded every 10 min for 3 to 5 consecutive days at each barn in turn. The data were collected at different geographical and climatic conditions. Therefore, the data collected by an outside station were used as covariates. A heat-stress model was used to determine the threshold temperature (THRT) at which a cow begins to increase its respiratory rate; THRT was the response variable in the statistical model. The THRT model takes in account assumed values of a cow's physiological characteristics: daily milk yield of 45 kg, containing 3.5% fat, and 3 mm fur depth. The independent variables were: orientation, barn type, roof slope, roof ridge, marginal height, roof type (fixed or sliding) and barn width. Results showed that the optimal barn for high-yielding cows is the loose-housing type, oriented with its long axis perpendicular to the prevailing wind direction. Advantageous to the design would be an open ridge or pagoda with marginal height of over 4.7 m for north-south orientation and over 5 m for east-west orientation, roof slope over 11%, and barn width between 43 and 51 m for north-south orientation but lower than 42 m for east-west orientation. A sliding roof was also found to be an excellent solution when outside yards are banned by environmental regulations.

  5. A cross strain Plasmodium falciparum microarray optimized for the transcriptome analysis of Plasmodium falciparum patient derived isolates

    KAUST Repository

    Subudhi, Amit

    2016-07-20

    Malarial parasite P. falciparum, an apicomplexan protozoan has a 23.3 MB nuclear genome and encodes ~ 5600 transcripts. The genetic diversity of the parasite within and across geographical zones is a challenge to gene expression studies which are essential for understanding of disease process, outcome and developing markers for diagnostics and prognostics. Here, we describe the strategy involved in designing a custom P. falciparum 15K array using the Agilent platform and Genotypic\\'s Right Design methodology to study the transcriptome of Indian field isolates for which genome sequence information is limited. The array contains probes representing genome sequences of two distinct geographical isolates (i.e. 3D7 and HB3) and sub-telomeric var gene sequences of a third isolate (IT4) known to adhere in culture condition. Probes in the array have been selected based on their efficiency to detect transcripts through a 244K array experimentation. Array performance for the 15K array, was evaluated and validated using RNA materials from P. falciparum clinical isolates. A large percentage (91%) of the represented transcripts was detected from Indian P. falciparum patient isolates. Replicated probes and multiple probes representing the same gene showed perfect correlation between them suggesting good probe performance. Additional transcripts could be detected due to inclusion of unique probes representing HB3 strain transcripts. Variant surface antigen (VSA) transcripts were detected by optimized probes representing the VSA genes of three geographically distinct strains. The 15K cross strain P. falciparum array has shown good efficiency in detecting transcripts from P. falciparum parasite samples isolated from patients. The low parasite loads and presence of host RNA makes arrays a preferred platform for gene expression studies over RNA-Seq.

  6. Host-Derived Sialic Acids Are an Important Nutrient Source Required for Optimal Bacterial Fitness In Vivo

    Directory of Open Access Journals (Sweden)

    Nathan D. McDonald

    2016-04-01

    Full Text Available A major challenge facing bacterial intestinal pathogens is competition for nutrient sources with the host microbiota. Vibrio cholerae is an intestinal pathogen that causes cholera, which affects millions each year; however, our knowledge of its nutritional requirements in the intestinal milieu is limited. In this study, we demonstrated that V. cholerae can grow efficiently on intestinal mucus and its component sialic acids and that a tripartite ATP-independent periplasmic SiaPQM strain, transporter-deficient mutant NC1777, was attenuated for colonization using a streptomycin-pretreated adult mouse model. In in vivo competition assays, NC1777 was significantly outcompeted for up to 3 days postinfection. NC1777 was also significantly outcompeted in in vitro competition assays in M9 minimal medium supplemented with intestinal mucus, indicating that sialic acid uptake is essential for fitness. Phylogenetic analyses demonstrated that the ability to utilize sialic acid was distributed among 452 bacterial species from eight phyla. The majority of species belonged to four phyla, Actinobacteria (members of Actinobacillus, Corynebacterium, Mycoplasma, and Streptomyces, Bacteroidetes (mainly Bacteroides, Capnocytophaga, and Prevotella, Firmicutes (members of Streptococcus, Staphylococcus, Clostridium, and Lactobacillus, and Proteobacteria (including Escherichia, Shigella, Salmonella, Citrobacter, Haemophilus, Klebsiella, Pasteurella, Photobacterium, Vibrio, and Yersinia species, mostly commensals and/or pathogens. Overall, our data demonstrate that the ability to take up host-derived sugars and sialic acid specifically allows V. cholerae a competitive advantage in intestinal colonization and that this is a trait that is sporadic in its occurrence and phylogenetic distribution and ancestral in some genera but horizontally acquired in others.

  7. Modeling of frequency-domain scalar wave equation with the average-derivative optimal scheme based on a multigrid-preconditioned iterative solver

    Science.gov (United States)

    Cao, Jian; Chen, Jing-Bo; Dai, Meng-Xue

    2018-01-01

    An efficient finite-difference frequency-domain modeling of seismic wave propagation relies on the discrete schemes and appropriate solving methods. The average-derivative optimal scheme for the scalar wave modeling is advantageous in terms of the storage saving for the system of linear equations and the flexibility for arbitrary directional sampling intervals. However, using a LU-decomposition-based direct solver to solve its resulting system of linear equations is very costly for both memory and computational requirements. To address this issue, we consider establishing a multigrid-preconditioned BI-CGSTAB iterative solver fit for the average-derivative optimal scheme. The choice of preconditioning matrix and its corresponding multigrid components is made with the help of Fourier spectral analysis and local mode analysis, respectively, which is important for the convergence. Furthermore, we find that for the computation with unequal directional sampling interval, the anisotropic smoothing in the multigrid precondition may affect the convergence rate of this iterative solver. Successful numerical applications of this iterative solver for the homogenous and heterogeneous models in 2D and 3D are presented where the significant reduction of computer memory and the improvement of computational efficiency are demonstrated by comparison with the direct solver. In the numerical experiments, we also show that the unequal directional sampling interval will weaken the advantage of this multigrid-preconditioned iterative solver in the computing speed or, even worse, could reduce its accuracy in some cases, which implies the need for a reasonable control of directional sampling interval in the discretization.

  8. Evaluation of an optimized protocol using human peripheral blood monocyte derived dendritic cells for the in vitro detection of sensitizers: Results of a ring study in five laboratories.

    Science.gov (United States)

    Reuter, Hendrik; Gerlach, Silke; Spieker, Jochem; Ryan, Cindy; Bauch, Caroline; Mangez, Claire; Winkler, Petra; Landsiedel, Robert; Templier, Marie; Mignot, Aurelien; Gerberick, Frank; Wenck, Horst; Aeby, Pierre; Schepky, Andreas

    2015-08-01

    Allergic contact dermatitis is a delayed T-cell mediated allergic response associated with relevant social and economic impacts. Animal experiments (e.g. the local lymph node assay) are still supplying most of the data used to assess the sensitization potential of new chemicals. However, the 7th amendment to the EU Cosmetic Directive have introduced a testing ban for cosmetic ingredients after March 2013. We have developed and optimized a stable and reproducible in vitro protocol based on human peripheral blood monocyte derived dendritic cells to assess the sensitization potential of chemicals. To evaluate the transferability and the predictivity of this PBMDCs based test protocol, a ring study was organized with five laboratories using seven chemicals with a known sensitization potential (one none-sensitizer and six sensitizers, including one pro-hapten). The results indicated that this optimized test protocol could be successfully transferred to all participating laboratories and allowed a correct assessment of the sensitization potential of the tested set of chemicals. This should allow a wider acceptance of PBMDCs as a reliable test system for the detection of human skin sensitizers and the inclusion of this protocol in the toolbox of in vitro methods for the evaluation of the skin sensitization potential of chemicals. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  9. Enantioselective extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and β-cyclodextrin derivative: Modeling and optimization through response surface methodology.

    Science.gov (United States)

    Wang, Jun; Liu, Qi; Rong, Liya; Yang, Hua; Jiao, Feipeng; Chen, Xiaoqing

    2016-10-07

    A novel aqueous two-phase system (ATPS) composed of β-cyclodextrin (β-CD) derivative and acetone was developed for enantioselective extraction of racemic phenylsuccinic acid (PSA). Binodal curves, tie-lines, and critical points for the investigated ATPS were determined and the experimental tie-lines data were successfully correlated by Othmer-Tobias, Bancroft, and Setschenow-type equations. ATPS containing sulfobutyl ether-β-CD (SBE-β-CD) exhibited better enantioselectivity than that using carboxymethyl-β-CD (CM-β-CD). To optimize enantioselective partitioning conditions of PSA in acetone/SBE-β-CD ATPS, three factors (PSA concentration, pH, and equilibrium temperature) were analyzed by using central composite design in response surface methodology. The calculated equilibrium constants of inclusion complexation are 1638.64M(-1) for SBE-β-CD-(R)-PSA and 835.84M(-1) for SBE-β-CD-(S)-PSA, respectively. Under the optimized conditions, the separation factor of 3.14 and high enrichment efficiency (ER=98.06%, ES=99.25%) were simultaneously achieved in a single step. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Optimizing patient derived mesenchymal stem cells as virus carriers for a Phase I clinical trial in ovarian cancer

    Directory of Open Access Journals (Sweden)

    Mader Emily K

    2013-01-01

    Full Text Available Abstract Background Mesenchymal stem cells (MSC can serve as carriers to deliver oncolytic measles virus (MV to ovarian tumors. In preparation for a clinical trial to use MSC as MV carriers, we obtained cells from ovarian cancer patients and evaluated feasibility and safety of this approach. Methods MSC from adipose tissues of healthy donors (hMSC and nine ovarian cancer patients (ovMSC were characterized for susceptibility to virus infection and tumor homing abilities. Results Adipose tissue (range 0.16-3.96 grams from newly diagnosed and recurrent ovarian cancer patients yielded about 7.41×106 cells at passage 1 (range 4–9 days. Phenotype and doubling times of MSC were similar between ovarian patients and healthy controls. The time to harvest of 3.0×108 cells (clinical dose could be achieved by day 14 (range, 9–17 days. Two of nine samples tested had an abnormal karyotype represented by trisomy 20. Despite receiving up to 1.6×109 MSC/kg, no tumors were seen in SCID beige mice and MSC did not promote the growth of SKOV3 human ovarian cancer cells in mice. The ovMSC migrated towards primary ovarian cancer samples in chemotaxis assays and to ovarian tumors in athymic mice. Using non-invasive SPECT-CT imaging, we saw rapid co-localization, within 5–8 minutes of intraperitoneal administration of MV infected MSC to the ovarian tumors. Importantly, MSC can be pre-infected with MV, stored in liquid nitrogen and thawed on the day of infusion into mice without loss of activity. MV infected MSC, but not virus alone, significantly prolonged the survival of measles immune ovarian cancer bearing animals. Conclusions These studies confirmed the feasibility of using patient derived MSC as carriers for oncolytic MV therapy. We propose an approach where MSC from ovarian cancer patients will be expanded, frozen and validated to ensure compliance with the release criteria. On the treatment day, the cells will be thawed, washed, mixed with virus, briefly

  11. Optimizing culture medium composition to improve oligodendrocyte progenitor cell yields in vitro from subventricular zone-derived neural progenitor cell neurospheres.

    Science.gov (United States)

    Franco, Paula G; Pasquini, Juana M; Silvestroff, Lucas

    2015-01-01

    Neural Stem and Progenitor Cells (NSC/NPC) are gathering tangible recognition for their uses in cell therapy and cell replacement therapies for human disease, as well as a model system to continue research on overall neural developmental processes in vitro. The Subventricular Zone is one of the largest NSC/NPC niches in the developing mammalian Central Nervous System, and persists through to adulthood. Oligodendrocyte progenitor cell (OPC) enriched cultures are usefull tools for in vitro studies as well as for cell replacement therapies for treating demyelination diseases. We used Subventricular Zone-derived NSC/NPC primary cultures from newborn mice and compared the effects of different growth factor combinations on cell proliferation and OPC yield. The Platelet Derived Growth Factor-AA and BB homodimers had a positive and significant impact on OPC generation. Furthermore, heparin addition to the culture media contributed to further increase overall culture yields. The OPC generated by this protocol were able to mature into Myelin Basic Protein-expressing cells and to interact with neurons in an in vitro co-culture system. As a whole, we describe an optimized in vitro method for increasing OPC.

  12. Principal component analysis- adaptive neuro-fuzzy inference system modeling and genetic algorithm optimization of adsorption of methylene blue by activated carbon derived from Pistacia khinjuk.

    Science.gov (United States)

    Ghaedi, M; Ghaedi, A M; Abdi, F; Roosta, M; Vafaei, A; Asghari, A

    2013-10-01

    In the present study, activated carbon (AC) simply derived from Pistacia khinjuk and characterized using different techniques such as SEM and BET analysis. This new adsorbent was used for methylene blue (MB) adsorption. Fitting the experimental equilibrium data to various isotherm models shows the suitability and applicability of the Langmuir model. The adsorption mechanism and rate of processes was investigated by analyzing time dependency data to conventional kinetic models and it was found that adsorption follow the pseudo-second-order kinetic model. Principle component analysis (PCA) has been used for preprocessing of input data and genetic algorithm optimization have been used for prediction of adsorption of methylene blue using activated carbon derived from P. khinjuk. In our laboratory various activated carbon as sole adsorbent or loaded with various nanoparticles was used for removal of many pollutants (Ghaedi et al., 2012). These results indicate that the small amount of proposed adsorbent (1.0g) is applicable for successful removal of MB (RE>98%) in short time (45min) with high adsorption capacity (48-185mgg(-1)). Copyright © 2013 Elsevier Inc. All rights reserved.

  13. Optimizing derivatization conditions using an experimental design and simultaneous estimation of artemether and lumefantrine by ratio first order derivative spectrophotometric method

    Directory of Open Access Journals (Sweden)

    Jenee Christian

    2017-09-01

    Full Text Available Artemether–lumefantrine is the most widely used artemisinin-based combination therapy for malaria. The present work aims to develop and validate a simple, accurate, precise and rapid ratio first order derivative spectrophotometric method for the simultaneous estimation of artemether and lumefantrine in a fixed dose combination tablet. The first step in development of the method was to derivatize artemether. As artemether does not show absorption in the UV region, it was derivatized using hydrochloric acid as the derivatizing agent. The derivatizing conditions were further optimized by full factorial multivariate approach, where the independent variables were volume of concentrated hydrochloric acid and time taken for artemether derivatization at room temperature. Furthermore, based on the statistical analysis, derivatizing conditions were optimized i.e. 1.3 ml of conc. HCl at room temperature for 30 min. At this condition, the artemether was found to absorb in the UV region satisfactorily, and the absorbance of lumefantrine was found to remain unaffected. The developed method showed good calibration data in the range of 5–30 μg/ml for artemether and 2–12 μg/ml for lumefantrine. The mean % recovery values were found to be 99.96–100.49% and 99.48–100.31% for artemether and lumefantrine, respectively. Additionally, the developed method was effectively applied in the estimation of artemether and lumefantrine in a commercial tablet (ARH-L DS tablets, suggesting that it can be practically applied for quality control of routinely examined drugs in combined dosage forms with the reduced expenditure of time.

  14. Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment.

    Science.gov (United States)

    Acharya, Munjal M; Martirosian, Vahan; Christie, Lori-Ann; Riparip, Lara; Strnadel, Jan; Parihar, Vipan K; Limoli, Charles L

    2015-01-01

    Past preclinical studies have demonstrated the capability of using human stem cell transplantation in the irradiated brain to ameliorate radiation-induced cognitive dysfunction. Intrahippocampal transplantation of human embryonic stem cells and human neural stem cells (hNSCs) was found to functionally restore cognition in rats 1 and 4 months after cranial irradiation. To optimize the potential therapeutic benefits of human stem cell transplantation, we have further defined optimal transplantation windows for maximizing cognitive benefits after irradiation and used induced pluripotent stem cell-derived hNSCs (iPSC-hNSCs) that may eventually help minimize graft rejection in the host brain. For these studies, animals given an acute head-only dose of 10 Gy were grafted with iPSC-hNSCs at 2 days, 2 weeks, or 4 weeks following irradiation. Animals receiving stem cell grafts showed improved hippocampal spatial memory and contextual fear-conditioning performance compared with irradiated sham-surgery controls when analyzed 1 month after transplantation surgery. Importantly, superior performance was evident when stem cell grafting was delayed by 4 weeks following irradiation compared with animals grafted at earlier times. Analysis of the 4-week cohort showed that the surviving grafted cells migrated throughout the CA1 and CA3 subfields of the host hippocampus and differentiated into neuronal (∼39%) and astroglial (∼14%) subtypes. Furthermore, radiation-induced inflammation was significantly attenuated across multiple hippocampal subfields in animals receiving iPSC-hNSCs at 4 weeks after irradiation. These studies expand our prior findings to demonstrate that protracted stem cell grafting provides improved cognitive benefits following irradiation that are associated with reduced neuroinflammation. ©AlphaMed Press.

  15. The optimization, kinetics and mechanism of m-cresol degradation via catalytic wet peroxide oxidation with sludge-derived carbon catalyst

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yamin [Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Wei, Huangzhao; Zhao, Ying [Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Sun, Wenjing [Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Sun, Chenglin, E-mail: clsun@dicp.ac.cn [Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China)

    2017-03-15

    Highlights: • The sludge derived carbon modified with 0 °C acid was used as catalyst in CWPO. • RSM was used to optimize CWPO reaction conditions of m-cresol for the first time. • The kinetic model was disclosed to be correlated with residue target concentration. • The proposed degradation pathways of m-cresol were well proven by DFT method. - Abstract: The sludge-derived carbon catalyst modified with 0 °C HNO{sub 3} solution was tested in catalytic wet peroxide oxidation of m-cresol (100 mg L{sup −1}) with systematical mathematical models and theoretical calculation for the first time. The reaction conditions were optimized by response surface methodology (RSM) as T = 60 °C, initial pH = 3.0, C{sub 0,H2O2(30%)} = 1.20 g L{sup −1} (lower than the stoichiometric amount of 1.80 g L{sup −1}) and C{sub cat} = 0.80 g L{sup −1}, with 96% of m-cresol and 47% of TOC converted after 16 min and 120 min of reaction, respectively, and ξ (mg TOC/g H{sub 2}O{sub 2} fed) = 83.6 mg/g. The end time of the first kinetic period in m-cresol model was disclosed to be correlated with the fixed residue m-cresol concentration of about 33%. Furthermore, the kinetic constants in models of TOC and H{sub 2}O{sub 2} exactly provide convincing proof of three-dimensional response surfaces analysis by RSM, which showed the influence of the interaction between organics and H{sub 2}O{sub 2} on effective H{sub 2}O{sub 2} utilization. The reaction intermediates over time were identified by gas chromatography–mass spectrometer based on kinetics analysis. Four degradation pathways for m-cresol were proposed, of which the possibility and feasibility were well proven by frontier molecule orbital theory and atomic charge distribution via density functional theory method.

  16. Exploring QSAR of Non-Nucleoside Reverse Transcriptase Inhibitors by Neural Networks: TIBO Derivatives

    Directory of Open Access Journals (Sweden)

    Driss Cherqaoui

    2004-01-01

    Full Text Available Abstract: Human Immunodeficiency Virus type 1 (HIV-1 reverse transcriptase is an important target for chemotherapeutic agents against the AIDS disease. 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H-ones (TIBO derivatives are potent non-nucleoside reverse transcriptase inhibitors (NNRTIs. In the present work, quantitative structure-activity relationship (QSAR analysis for a set of 82 TIBO derivatives has been investigated by means of a three-layered neural network (NN. It has been shown that NN can be a potential tool in the investigation of QSAR analysis compared with the models given in the literature. NN gave good statistical results both in fitting and prediction processes (0.861 ≤ r² ≤ 0.928, 0.839 ≤q² ≤ 0.845. The relevant factors controlling the anti-HIV-1 activity of TIBO derivatives have been identified. The results are along the same lines as those of our previous studies on HEPT derivatives and indicate the importance of the hydrophobic parameter in modeling the QSAR for TIBO derivatives.

  17. Deriving Optimal End of Day Storage for Pumped-Storage Power Plants in the Joint Energy and Reserve Day-Ahead Scheduling

    Directory of Open Access Journals (Sweden)

    Manuel Chazarra

    2017-06-01

    Full Text Available This paper presents a new methodology to maximise the income and derive the optimal end of day storage of closed-loop and daily-cycle pumped-storage hydropower plants. The plants participate in the day-ahead energy market as a price-taker and in the secondary regulation reserve market as a price-maker, in the context of the Iberian electricity system. The real-time use of the committed reserves is considered in the model formulation. The operation of the plants with the proposed methodology is compared to the ones that use an end of day storage of an empty reservoir or half of the storage capacity. Results show that the proposed methodology increases the maximum theoretical income in all the plants analysed both if they only participate in the day-ahead energy market and if they also participate in the secondary regulation service. It is also shown that the increase in the maximum theoretical income strongly depends on the size of the plant. In addition, it is proven that the end of day storages change notably in the new reserve-driven strategies of pumped-storage hydropower plants and that the proposed methodology is even more recommended if the secondary regulation service is considered.

  18. Lipase-catalyzed Baeyer-Villiger Oxidation ofcellulose-derived Levoglucosenone into(S-gamma-hydroxymethyl-□alpha,beta□-butenolide:Optimization by Response SurfaceMethodology

    Directory of Open Access Journals (Sweden)

    Andreia eTeixeira

    2016-04-01

    Full Text Available Cellulose-derived levoglucosenone (LGO has been efficiently converted into pure (S-gamma-hydroxymethyl-alpha,beta-butenolide (HBO, a chemical platform suited for the synthesis of drugs, flavors and antiviral agents. This process involves two-steps: a lipase-catalyzed Baeyer-Villager oxidation of LGO followed by an acid hydrolysis of the reaction mixture to provide pure HBO. Response surface methodology (RSM, based on central composite face-centered (CCF design, was employed to evaluate the factors effecting the enzyme-catalyzed reaction: pka of solid buffer (7.2 - 9.6, LGO concentration (0.5 - 1 M and enzyme loading (55 - 285 PLU.mmol-1. Enzyme loading and pka of solid buffer were found to be important factors to the reaction efficiency (as measured by the conversion of LGO while only the later had significant effects on the enzyme recyclability (as measured by the enzyme residual activity. LGO concentration influences both responses by its interaction with the enzyme loading and pka of solid buffer. The optimal conditions which allow to convert at least 80% of LGO in 2 hours at 40 °C and reuse the enzyme for a subsequent cycle were found to be: solid buffer pka = 7.5, [LGO] = 0.50 M and 113 PLU.mmol-1 for the lipase. A good agreement between experimental and predicted values was obtained and the validity of the model confirmed (p-value 0.05.

  19. Lipase-catalyzed Baeyer-Villiger Oxidation of cellulose-derived Levoglucosenone into (S)-gamma-hydroxymethyl-□alpha,beta□-butenolide: Optimization by Response Surface Methodology

    Science.gov (United States)

    Teixeira, Andreia; Flourat, Amandine; Peru, Aurelien; Brunissen, Fanny; Allais, Florent

    2016-04-01

    Cellulose-derived levoglucosenone (LGO) has been efficiently converted into pure (S)-gamma-hydroxymethyl-alpha,beta-butenolide (HBO), a chemical platform suited for the synthesis of drugs, flavors and antiviral agents. This process involves two-steps: a lipase-catalyzed Baeyer-Villager oxidation of LGO followed by an acid hydrolysis of the reaction mixture to provide pure HBO. Response surface methodology (RSM), based on central composite face-centered (CCF) design, was employed to evaluate the factors effecting the enzyme-catalyzed reaction: pka of solid buffer (7.2 - 9.6), LGO concentration (0.5 - 1 M) and enzyme loading (55 - 285 PLU.mmol-1). Enzyme loading and pka of solid buffer were found to be important factors to the reaction efficiency (as measured by the conversion of LGO) while only the later had significant effects on the enzyme recyclability (as measured by the enzyme residual activity). LGO concentration influences both responses by its interaction with the enzyme loading and pka of solid buffer. The optimal conditions which allow to convert at least 80% of LGO in 2 hours at 40 °C and reuse the enzyme for a subsequent cycle were found to be: solid buffer pka = 7.5, [LGO] = 0.50 M and 113 PLU.mmol-1 for the lipase. A good agreement between experimental and predicted values was obtained and the validity of the model confirmed (p-value 0.05).

  20. Automated hybrid closed-loop control with a proportional-integral-derivative based system in adolescents and adults with type 1 diabetes: individualizing settings for optimal performance.

    Science.gov (United States)

    Ly, Trang T; Weinzimer, Stuart A; Maahs, David M; Sherr, Jennifer L; Roy, Anirban; Grosman, Benyamin; Cantwell, Martin; Kurtz, Natalie; Carria, Lori; Messer, Laurel; von Eyben, Rie; Buckingham, Bruce A

    2017-08-01

    Automated insulin delivery systems, utilizing a control algorithm to dose insulin based upon subcutaneous continuous glucose sensor values and insulin pump therapy, will soon be available for commercial use. The objective of this study was to determine the preliminary safety and efficacy of initialization parameters with the Medtronic hybrid closed-loop controller by comparing percentage of time in range, 70-180 mg/dL (3.9-10 mmol/L), mean glucose values, as well as percentage of time above and below target range between sensor-augmented pump therapy and hybrid closed-loop, in adults and adolescents with type 1 diabetes. We studied an initial cohort of 9 adults followed by a second cohort of 15 adolescents, using the Medtronic hybrid closed-loop system with the proportional-integral-derivative with insulin feed-back (PID-IFB) algorithm. Hybrid closed-loop was tested in supervised hotel-based studies over 4-5 days. The overall mean percentage of time in range (70-180 mg/dL, 3.9-10 mmol/L) during hybrid closed-loop was 71.8% in the adult cohort and 69.8% in the adolescent cohort. The overall percentage of time spent under 70 mg/dL (3.9 mmol/L) was 2.0% in the adult cohort and 2.5% in the adolescent cohort. Mean glucose values were 152 mg/dL (8.4 mmol/L) in the adult cohort and 153 mg/dL (8.5 mmol/L) in the adolescent cohort. Closed-loop control using the Medtronic hybrid closed-loop system enables adaptive, real-time basal rate modulation. Initializing hybrid closed-loop in clinical practice will involve individualizing initiation parameters to optimize overall glucose control. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. Estimation of total released amount of Cs-137 and Cs-134 derived from TEPCO-FNPP1 accident into the North Pacific Ocean by using optimal interpolation analysis

    Science.gov (United States)

    Inomata, Yayoi; Aoyama, Michio; Tsubono, Takaki; Tsumune, Daisuke; Hirose, Katsumi

    2015-04-01

    The oceanic distribution of Cs-137 and Cs-134 released from the Tokyo Electric Power Company-Fukushima Daiichi Nuclear Power Plant (TEPCO-FNPP1) accident were investigated by using the optimal interpolation (OI) analysis. The two domains (open ocean, >141.5°E; coastal region near the TEPCO-FNPP1, inventory of FNPP1-released Cs-134 in the North Pacific Ocean is estimated to be 15.2±1.8 PBq. In these, about half (8.3±1.8 PBq) of the total released Cs-134 amount existed in the coastal region near the TEPCO-FNPP1. It appeared that the total OICs134 inventory, which is defined as a total Cs-134 inventory in the coastal area near the TEPCO-FNPP1, is controlled by direct release, atmospheric deposition, and coastal current system. Leak of stagnant water induced by heavy rainfall would also cause the increase of the total OICs134 inventory. After the direct discharge of the contaminated water ceased on 6 April, 2011, the total OICs134 inventory exponentially with a half-time of 4.2±0.5 days and became to about 2.0±0.4 PBq at the middle of May 2011. Considering that the Cs-134/Cs-137 activity ratios for the FNPP1 accident were very close to one (0.99±0.03) and extremely uniform during the first month, the total amount of Cs-137 released by the TEPCO-FNPP1 accident reached to 20% of a current North Pacific inventory (60 PBq, Aoyama et al., 2012) of bomb-derived Cs-137 injected in the 1950s and early 1960s.

  2. Optimization and modeling of preconcentration and determination of dyes based on ultrasound assisted-dispersive liquid-liquid microextraction coupled with derivative spectrophotometry.

    Science.gov (United States)

    Alipanahpour Dil, Ebrahim; Ghaedi, Mehrorang; Asfaram, Arash

    2017-01-01

    Present study is based on describing an ultrasound-assisted dispersive liquid-liquid microextraction coupled with derivative spectrophotometry (UAS-DLLME-UV-vis) as useful technique for selective determination of crystal violet (CV) and azure b (Az-B). The significant factors like pH, extractor volume, disperser value and extraction time contribution and their numerical coefficient in quadratic model were calculated according to central composite design (CCD). According to desirability function (DF) as good criterion the best experimental conditions was adjusted and selected at pH of 7.0, 170μL of chloroform, 800μL of ethanol that strongly mixed with the aqueous phase via 4min sonication. Additionally, under study system was modeled by trained artificial neural networks (ANNs) as fitness function with acceptable error of MSE 2.97×10 -06 and 1.15×10 -05 with R 2 : 0.9999 and 0.9997 for CV and Az-B, respectively. The optimum conditions by using genetic algorithm (GA) method was pH of 6.3, 160μL of chloroform, 740μL of ethanol and 4.5min sonication. Under above specified and optimize conditions, the predicted extraction percentage were 99.80 and 102.20% for CV and Az-B, respectively. The present UAS-DLLME-UV-vis procedure has minimum interference from other substances assign to the matrix, which candidate this method as good alternative to quantify under study dyes content with recoveries in the range of 86-100% for dyes. The detection limits were 2.043ngmL -1 and 1.72ngmL -1 , and limits of quantitation were 6.81ngmL -1 and 5.727ngmL -1 for CV and Az-B, respectively. The proposed methodology was successfully applied for quantification of under study analytes at different media. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Optimizing finite element predictions of local subchondral bone structural stiffness using neural network-derived density-modulus relationships for proximal tibial subchondral cortical and trabecular bone.

    Science.gov (United States)

    Nazemi, S Majid; Amini, Morteza; Kontulainen, Saija A; Milner, Jaques S; Holdsworth, David W; Masri, Bassam A; Wilson, David R; Johnston, James D

    2017-01-01

    Quantitative computed tomography based subject-specific finite element modeling has potential to clarify the role of subchondral bone alterations in knee osteoarthritis initiation, progression, and pain. However, it is unclear what density-modulus equation(s) should be applied with subchondral cortical and subchondral trabecular bone when constructing finite element models of the tibia. Using a novel approach applying neural networks, optimization, and back-calculation against in situ experimental testing results, the objective of this study was to identify subchondral-specific equations that optimized finite element predictions of local structural stiffness at the proximal tibial subchondral surface. Thirteen proximal tibial compartments were imaged via quantitative computed tomography. Imaged bone mineral density was converted to elastic moduli using multiple density-modulus equations (93 total variations) then mapped to corresponding finite element models. For each variation, root mean squared error was calculated between finite element prediction and in situ measured stiffness at 47 indentation sites. Resulting errors were used to train an artificial neural network, which provided an unlimited number of model variations, with corresponding error, for predicting stiffness at the subchondral bone surface. Nelder-Mead optimization was used to identify optimum density-modulus equations for predicting stiffness. Finite element modeling predicted 81% of experimental stiffness variance (with 10.5% error) using optimized equations for subchondral cortical and trabecular bone differentiated with a 0.5g/cm(3) density. In comparison with published density-modulus relationships, optimized equations offered improved predictions of local subchondral structural stiffness. Further research is needed with anisotropy inclusion, a smaller voxel size and de-blurring algorithms to improve predictions. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Optimization of the culturing conditions of human umbilical cord blood-derived endothelial colony-forming cells under xeno-free conditions applying a transcriptomic approach

    NARCIS (Netherlands)

    Zeisberger, Steffen M.; Zoller, Stefan; Riegel, Mariluce; Chen, Shuhua; Krenning, Guido; Harmsen, Martin C.; Sachinidis, Agapios; Zisch, Andreas H.

    Establishment of fetal bovine serum (FBS)-free cell culture conditions is essential for transplantation therapies. Blood-derived endothelial colony-forming cells (ECFCs) are potential candidates for regenerative medicine applications. ECFCs were isolated from term umbilical cord blood units and

  5. Optimization of the tissue source, malignancy, and initial substrate of tumor cell-derived matrices to increase cancer cell chemoresistance against 5-fluorouracil.

    Science.gov (United States)

    Hoshiba, Takashi; Tanaka, Masaru

    2015-02-13

    The low chemoresistance of in vitro cancer cells inhibits the development of new anti-cancer drugs. Thus, development of a new in vitro culture system is required to increase the chemoresistance of in vitro cancer cells. Tumor cell-derived matrices have been reported to increase the chemoresistance of in vitro cancer cells. However, it remains unclear how tissue sources and the malignancy of cells used for the preparation of matrices affect the chemoresistance of tumor cell-derived matrices. Moreover, it remains unclear how the initial substrates used for the preparation of matrices affect the chemoresistance. In this study, we compared the effects of tissue sources and the malignancy of tumor cells, as well as the effect of the initial substrates on chemoresistance against 5-fluorouracil (5-FU). The chemoresistance of breast and colon cancer cells against 5-FU increased on matrices prepared with cells derived from the corresponding original tissues with higher malignancy. Moreover, the chemoresistance against 5-FU was altered on matrices prepared using different initial substrates that exhibited different characteristics of protein adsorption. Taken together, these results indicated that the appropriate selection of tissue sources, malignancy of tumor cells, and initial substrates used for matrix preparation is important for the preparation of tumor cell-derived matrices for chemoresistance assays. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Optimized renormalization group flows

    Science.gov (United States)

    Litim, Daniel F.

    2001-11-01

    We study the optimization of exact renormalization group (ERG) flows. We explain why the convergence of approximate solutions towards the physical theory is optimized by appropriate choices of the regularization. We consider specific optimized regulators for bosonic and fermionic fields and compare the optimized ERG flows with generic ones. This is done up to second order in the derivative expansion at both vanishing and nonvanishing temperature. We find that optimized flows at finite temperature factorize. This corresponds to the disentangling of thermal and quantum fluctuations. A similar factorization is found at second order in the derivative expansion. The corresponding optimized flow for a ``proper-time renormalization group'' is also provided to leading order in the derivative expansion.

  7. Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate

    Directory of Open Access Journals (Sweden)

    Younes Abrouki

    2014-01-01

    Full Text Available A simple protocol for the efficient preparation of β-mercapto carbonyl derivatives as antimycobacterial drugs has been achieved via Thia-Michael reaction between chalcones derivatives and thiols in the presence of calcium pyrophosphate as a heterogeneous catalyst under mild reaction conditions. The central composite design was used to design an experimental program to provide data to model the effects of various factors on reaction yield (Y. The variables chosen were catalyst weight X1, reaction time X2, and solvent volume X3. The mathematical relationship of reaction yield on the three significant independent variables can be approximated by a nonlinear polynomial model. Predicted values were found to be in good agreement with experimental values. The optimum reaction conditions for reaction model (chalcone and thiophenol obtained by response surface were applied to other substrates. This procedure provides several advantages such as high yield, clean product formation, and short reaction time.

  8. Linearly constrained minimax optimization

    DEFF Research Database (Denmark)

    Madsen, Kaj; Schjær-Jacobsen, Hans

    1978-01-01

    We present an algorithm for nonlinear minimax optimization subject to linear equality and inequality constraints which requires first order partial derivatives. The algorithm is based on successive linear approximations to the functions defining the problem. The resulting linear subproblems...

  9. Optimal exploration target zones

    CSIR Research Space (South Africa)

    Debba, Pravesh

    2008-09-01

    Full Text Available This research describes a quantitative methodology for deriving optimal exploration target zones based on a probabilistic mineral prospectivity map. In order to arrive at out objective, we provide a plausible answer to the following question: "Which...

  10. Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors.

    Science.gov (United States)

    Li, Bei; Cociorva, Oana M; Nomanbhoy, Tyzoon; Weissig, Helge; Li, Qiang; Nakamura, Kai; Liyanage, Marek; Zhang, Melissa C; Shih, Ann Y; Aban, Arwin; Hu, Yi; Cajica, Julia; Pham, Lan; Kozarich, John W; Shreder, Kevin R

    2013-09-15

    As the result of a rhJNK1 HTS, the imidazo[1,2-a]quinoxaline 1 was identified as a 1.6 μM rhJNK1 inhibitor. Optimization of this compound lead to AX13587 (rhJNK1 IC50=160 nM) which was co-crystallized with JNK1 to identify key molecular interactions. Kinase profiling against 125+ kinases revealed AX13587 was an inhibitor of JNK, MAST3, and MAST4 whereas its methylene homolog AX14373 (native JNK1 IC50=47 nM) was a highly specific JNK inhibitor. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. Optimization Technology of the LHS-1 Strain for Degrading Gallnut Water Extract and Appraisal of Benzene Ring Derivatives from Fermented Gallnut Water Extract Pyrolysis by Py-GC/MS

    Directory of Open Access Journals (Sweden)

    Chengzhang Wang

    2017-12-01

    Full Text Available Gallnut water extract (GWE enriches 80~90% of gallnut tannic acid (TA. In order to study the biodegradation of GWE into gallic acid (GA, the LHS-1 strain, a variant of Aspergillus niger, was chosen to determine the optimal degradation parameters for maximum production of GA by the response surface method. Pyrolysis–gas chromatography–mass spectrometry (Py-GC/MS was first applied to appraise benzene ring derivatives of fermented GWE (FGWE pyrolysis by comparison with the pyrolytic products of a tannic acid standard sample (TAS and GWE. The results showed that optimum conditions were at 31 °C and pH of 5, with a 50-h incubation period and 0.1 g·L−1 of TA as substrate. The maximum yields of GA and tannase were 63~65 mg·mL−1 and 1.17 U·mL−1, respectively. Over 20 kinds of compounds were identified as linear hydrocarbons and benzene ring derivatives based on GA and glucose. The key benzene ring derivatives were 3,4,5-trimethoxybenzoic acid methyl ester, 3-methoxy-1,2-benzenediol, and 4-hydroxy-3,5-dimethoxy-benzoic acid hydrazide.

  12. Optimal gadolinium dose level for magnetic resonance imaging (MRI) contrast enhancement of U87-derived tumors in athymic nude rats for the assessment of photodynamic therapy

    Science.gov (United States)

    Cross, Nathan; Varghai, Davood; Flask, Chris A.; Feyes, Denise K.; Oleinick, Nancy L.; Dean, David

    2009-02-01

    This study aims to determine the effect of varying gadopentetate dimeglumine (Gd-DTPA) dose on Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) tracking of brain tumor photodynamic therapy (PDT) outcome. Methods: We injected 2.5 x 105 U87 cells (derived from human malignant glioma) into the brains of six athymic nude rats. After 9, 12, and 13 days DCE-MRI images were acquired on a 9.4 T micro-MRI scanner before and after administration of 100, 150, or 200 μL of Gd-DTPA. Results: Tumor region normalized DCE-MRI scan enhancement at peak was: 1.217 over baseline (0.018 Standard Error [SE]) at the 100 μL dose, 1.339 (0.013 SE) at the 150 μL dose, and 1.287 (0.014 SE) at the 200 μL dose. DCE-MRI peak tumor enhancement at the 150 μL dose was significantly greater than both the 100 μL dose (p < 3.323E-08) and 200 μL dose (p < 0.0007396). Discussion: In this preliminary study, the 150 μL Gd-DTPA dose provided the greatest T1 weighted contrast enhancement, while minimizing negative T2* effects, in DCE-MRI scans of U87-derived tumors. Maximizing Gd-DTPA enhancement in DCE-MRI scans may assist development of a clinically robust (i.e., unambiguous) technique for PDT outcome assessment.

  13. Optimization and Optimal Control

    CERN Document Server

    Chinchuluun, Altannar; Enkhbat, Rentsen; Tseveendorj, Ider

    2010-01-01

    During the last four decades there has been a remarkable development in optimization and optimal control. Due to its wide variety of applications, many scientists and researchers have paid attention to fields of optimization and optimal control. A huge number of new theoretical, algorithmic, and computational results have been observed in the last few years. This book gives the latest advances, and due to the rapid development of these fields, there are no other recent publications on the same topics. Key features: Provides a collection of selected contributions giving a state-of-the-art accou

  14. Multi-responses optimization of simultaneous biosorption of cationic dyes by live yeast Yarrowia lipolytica 70562 from binary solution: Application of first order derivative spectrophotometry.

    Science.gov (United States)

    Dil, Ebrahim Alipanahpour; Ghaedi, Mehrorang; Ghezelbash, Gholam Reza; Asfaram, Arash

    2017-05-01

    Present study is based on application of live yeast Yarrowia lipolytica 70562 as new biosorbent was investigated for the simultaneous biosorption of Crystal Violet (CV) and Brilliant Green (BG) from wastewater. The effect of operating parameters such as initial dye concentrations (6-14mgL -1 ), solution pH (4.0-8.0) and contact time (4-20h) was investigated by response surface methodology (RSM) for modeling and optimization of biosorption process and accordingly the best operational conditions was set as: initial CV and BG concentration of 8.0, and 10mgL -1 , pH of 7.0 and contact time of 16h. Above specified conditions lead to achievement of maximum biosorption of 98.823% and 99.927% for CV and BG dyes, respectively. The experimental equilibrium data well explained according to Langmuir isotherm model with maximum biosorption capacity of 65.359 and 56.497mgg -1 for BG and CV, respectively. The second order and intraparticle diffusion models as cooperative mechanism has high efficiency and performance for interpretation of real data. Copyright © 2017. Published by Elsevier Inc.

  15. An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo score and the simple clinical colitis activity index.

    Science.gov (United States)

    Bewtra, Meenakshi; Brensinger, Colleen M; Tomov, Vesselin T; Hoang, Tram B; Sokach, Carly E; Siegel, Corey A; Lewis, James D

    2014-06-01

    There is a need for simple, noninvasive patient-driven disease assessment instruments in ulcerative colitis (UC). We sought to further assess and refine the previous described 6-point Mayo score. A cross-sectional study of 282 UC patients was conducted assessing the correlation of the 2 patient-reported Mayo score components (6-point Mayo score) with the simple clinical colitis activity index (SCCAI) and a single Likert scale of patient-reported disease activity. Spearman's correlation, sensitivity, specificity, and area under the receiver operating curves (AUC) were calculated. A separate validation study in 59 UC patients was also conducted. Participants predominantly had long-standing disease (83%) and were in self-reported remission (63%). The 6-point Mayo score correlated well with the SCCAI (rho = 0.71; P < 0.0001) and patient-reported disease activity (rho = 0.65; P < 0.0001). Using a cutpoint of 1.5, the 6-point Mayo score had 83% sensitivity and 72% specificity for patient-defined remission, and 89% sensitivity and 67% specificity for SCCAI-defined remission (score, <2.5). The 6-point Mayo score and SCCAI had similar accuracy of predicting patient-defined remission (AUC = 0.84 and 0.87, respectively). Addition of the SCCAI general well-being question to the 6-point Mayo improved the predictive ability for patient-defined remission; and a new weighted score had an AUC of 0.89 in the development cohort and 0.93 in the validation cohort. The optimal cutpoint was 1.6. The patient-reported UC severity index that includes stool frequency, bleeding, and general well-being accurately measures clinical disease activity without requiring direct physician contact.

  16. Design and optimization of N-acylhydrazone pyrimidine derivatives as E. coli PDHc E1 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study.

    Science.gov (United States)

    He, Haifeng; Xia, Hongying; Xia, Qin; Ren, Yanliang; He, Hongwu

    2017-10-15

    By targeting the thiamin diphosphate (ThDP) binding site of Escherichia coli (E. coli) pyruvate dehydrogenase multienzyme complex E1 (PDHc E1), a series of novel 'open-chain' classes of ThDP analogs A, B, and C with N-acylhydrazone moieties was designed and synthesized to explore their activities against E. coli PHDc E1 in vitro and their inhibitory activity against microbial diseases were further evaluated in vivo. As a result, A1-23 exhibited moderate to potent inhibitory activities against E. coli PDHc E1 (IC 50 =0.15-23.55μM). The potent inhibitors A13, A14, A15, C2, had strong inhibitory activities with IC 50 values of 0.60, 0.15, 0.39 and 0.34μM against E. coli PDHc E1 and with good enzyme-selective inhibition between microorganisms and mammals. Especially, the most powerful inhibitor A14 could 99.37% control Xanthimonas oryzae pv. Oryzae. Furthermore, the binding features of compound A14 within E. coli PDHc E1 were investigated to provide useful insights for the further construction of new inhibitor by molecular docking, site-directed mutagenesis, and enzymatic assays. The results indicated that A14 had most powerful inhibition against E. coli PDHc E1 due to the establishment of stronger interaction with Glu571, Met194, Glu522, Leu264 and Phe602 at active site of E.coli PDHc E1. It could be used as a lead compound for further optimization, and may have potential as a new microbicide. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Optimization of cell-wall skeleton derived from Mycobacterium bovis BCG Tokyo 172 (SMP-105) emulsion in delayed-type hypersensitivity and antitumor models.

    Science.gov (United States)

    Miyauchi, M; Murata, M; Fukushima, A; Sato, T; Nakagawa, M; Fujii, T; Koseki, N; Chiba, N; Kashiwazaki, Y

    2012-08-01

    Cell-wall skeleton prepared from Mycobacterium bovis BCG (BCG-CWS) is known as a potent adjuvant and has been shown to possess antitumor activity in many non-clinical and clinical studies. As there are no approved BCG-CWS formulations for cancer therapy, we investigated the potential for cancer immunotherapy of SMP-105, our originally produced BCG-CWS. For optimizing SMP-105 emulsion, we compared the effects of drakeoland squalane-based SMP-105 emulsions on IFN-γ production in rats and evaluated their ability to induce skin reaction in guinea pigs. Both emulsions had the same activity in both experiments. We selected squalane as base material and produced two types of squalane-based formulations (vialed emulsion and pumped emulsion) that can easily be prepared as oil-in-water emulsions. Although the vialed emulsion showed the same pattern of distribution as a usual homogenized emulsion, the pumped emulsion showed more uniform distribution than the other two emulsions. Whereas both emulsions enhanced strong delayed type hypersensitivity (DTH) reaction in a mouse model, the pumped emulsion induced slightly smaller edema. Data on oil droplet size distribution suggest that few micrometer oil droplet size might be appropriate for oil-in-water microemulsion of SMP-105. The antitumor potency of SMP-105 emulsion was stronger than that of some of the launched toll-like receptor (TLR) agonists (Aldara cream, Picibanil, and Immunobladder). Aldara and Picibanil showed limited antitumor effectiveness, while Immunobladder had almost the same effect as SMP-105 at the highest dose, but needed about 10 times the amount of SMP-105. These findings first indicate that SMP-105 has great potential in cancer immunotherapy.

  18. Application of experimental design and derivative spectrophotometry methods in optimization and analysis of biosorption of binary mixtures of basic dyes from aqueous solutions.

    Science.gov (United States)

    Asfaram, Arash; Ghaedi, Mehrorang; Ghezelbash, Gholam Reza; Pepe, Francesco

    2017-05-01

    Simultaneous biosorption of malachite green (MG) and crystal violet (CV) on biosorbent Yarrowia lipolytica ISF7 was studied. An appropriate derivative spectrophotometry technique was used to evaluate the concentration of each dye in binary solutions, despite significant interferences in visible light absorbances. The effects of pH, temperature, growth time, initial MG and CV concentration in batch experiments were assessed using Design of Experiment (DOE) according to central composite second order response surface methodology (RSM). The analysis showed that the greatest biosorption efficiency (>99% for both dyes) can be obtained at pH 7.0, T=28°C, 24h mixing and 20mgL -1 initial concentrations for both MG and CV dyes. The quadratic constructed equation ability for fitting experimental data is judged based on criterions like R 2 values, significant p and lack-of-fit value strongly confirm its high adequacy and applicability for prediction of revel behavior of the system under study. The proposed model showed very high correlation coefficients (R 2 =0.9997 for CV and R 2 =0.9989 for MG), while supported by closeness of predicted and experimental value. A kinetic analysis was carried out, showing that for both dyes a pseudo-second order kinetic model adequately describes the available data. The Langmuir isotherm model in single and binary components has better performance for description of dyes biosorption with maximum monolayer biosorption capacity of 59.4 and 62.7mgg -1 in single component and 46.4 and 50.0mgg -1 for CV and MB in binary components, respectively. The surface structure of biosorbents and the possible biosorbents-dyes interactions between were also evaluated by Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). The values of thermodynamic parameters including ΔG° and ΔH° strongly confirm which method is spontaneous and endothermic. Copyright © 2017. Published by Elsevier Inc.

  19. Optimized blanching reduces the host cell protein content and substantially enhances the recovery and stability of two plant derived malaria vaccine candidates

    Directory of Open Access Journals (Sweden)

    Stephan eMenzel

    2016-02-01

    Full Text Available Plants provide an advantageous expression platform for biopharmaceutical proteins because of their low pathogen burden and potential for inexpensive, large-scale production. However, the purification of target proteins can be challenging due to issues with extraction, the removal of host cell proteins (HCPs, and low expression levels. The heat treatment of crude extracts can reduce the quantity of HCPs by precipitation thus increasing the purity of the target protein and streamlining downstream purification. In the overall context of downstream process development for plant-derived malaria vaccine candidates, we applied a design-of-experiments approach to enhance HCP precipitation from Nicotiana benthamiana extracts generated after transient expression, using temperatures in the 20−80°C range, pH values of 3.0−8.0 and incubation times of 0−60 min. We also investigated the recovery of two protein-based malaria vaccine candidates under these conditions and determined their stability in the heat-treated extract while it was maintained at room temperature for 24 h. The heat precipitation of HCPs was also carried out by blanching intact plants in water or buffer prior to extraction in a blender. Our data show that all the heat precipitation methods reduced the amount of HCP in the crude plant extracts by more than 80%, simplifying the subsequent downstream processing steps. Furthermore, when the heat treatment was performed at 80°C rather than 65°C, both malaria vaccine candidates were more stable after extraction and the recovery of both proteins increased by more than 30%.

  20. American derivatives : a review

    OpenAIRE

    Aase, Knut K.

    1997-01-01

    The paper gives an overview over the theory of pricing and hedging financial derivatives that can be exercised at any time during a fixed time interval [0, T]. The analysis makes use of the theory of optimal stopping, and as such it constitutes an interesting application of probability theory to the theory of financial economics. In this paper we concentrate on the main principles involved only, which means, for example, that we abstract from derivatives where the underlying asset pays ou...

  1. An automated microscale platform for evaluation and optimization of oxidative bioconversion processes.

    Science.gov (United States)

    Baboo, Jasmin Z; Galman, James L; Lye, Gary J; Ward, John M; Hailes, Helen C; Micheletti, Martina

    2012-01-01

    In this work an integrated robotic platform has been used for the development of a fully automated microscale process sequence comprising fermentation and bioconversion using E. coli TOP10 [pQR210] expressing cyclohexanone monooxygenase (CHMO). Ninety six-Deep Square Well (96-DSW) microtiter plates were used for microbial culture and enzyme-catalyzed conversion, where plate preparation, reagent addition, and sampling were all carried out without manual intervention. The adoption of automated robotic procedures has enabled the rapid collection of kinetic data for whole process optimization at the microscale. This high-throughput approach enabled a range of amino acid sources for media formulation and well fill volumes to be investigated highlighting when nutritional limitation and oxygen limitations took place. The automated process sequence has been applied to test six CHMO substrates including norcamphor and cycloheptanone all of which to the best of our knowledge have yet to be tested with E. coli TOP10 [pQR210]. Substrate specificity and product selectivity were effectively demonstrated and compared to both the natural substrate cyclohexanone and the model substrate bicyclo[3.2.0]hept-2-en-6-one used to demonstrate asymmetric synthesis. The results obtained using the developed process sequence could be reproduced at 75 L scale when a matched oxygen transfer coefficient k(L) a approach was used. The study demonstrates how automated microscale processing enables the rapid collection of kinetic quantitative data in a robust manner with clear implications for accelerating bioprocess development, optimization, and scale-up. Copyright © 2012 American Institute of Chemical Engineers (AIChE).

  2. Methodology for deriving optimal exploration target zones

    CSIR Research Space (South Africa)

    Debba, Pravesh

    2010-03-01

    Full Text Available VISUALISATION PositionIT – March 2010 55 1 N(Bt D) 1 N(Bt D) 1 N(Bt D) 1 N(Bt D)? pyrophyllite but slightly darker (i.e. lower ratios) for illite (Fig. 2a). The first three minerals are predominant in advanced...

  3. Optimal control for chemical engineers

    CERN Document Server

    Upreti, Simant Ranjan

    2013-01-01

    Optimal Control for Chemical Engineers gives a detailed treatment of optimal control theory that enables readers to formulate and solve optimal control problems. With a strong emphasis on problem solving, the book provides all the necessary mathematical analyses and derivations of important results, including multiplier theorems and Pontryagin's principle.The text begins by introducing various examples of optimal control, such as batch distillation and chemotherapy, and the basic concepts of optimal control, including functionals and differentials. It then analyzes the notion of optimality, de

  4. Guided randomness in optimization

    CERN Document Server

    Clerc, Maurice

    2015-01-01

    The performance of an algorithm used depends on the GNA. This book focuses on the comparison of optimizers, it defines a stress-outcome approach which can be derived all the classic criteria (median, average, etc.) and other more sophisticated.   Source-codes used for the examples are also presented, this allows a reflection on the ""superfluous chance,"" succinctly explaining why and how the stochastic aspect of optimization could be avoided in some cases.

  5. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.

    Science.gov (United States)

    Li, Lian-Sheng; Zhou, Yuefen; Murphy, Douglas E; Stankovic, Nebojsa; Zhao, Jingjing; Dragovich, Peter S; Bertolini, Thomas; Sun, Zhongxiang; Ayida, Benjamin; Tran, Chinh V; Ruebsam, Frank; Webber, Stephen E; Shah, Amit M; Tsan, Mei; Showalter, Richard E; Patel, Rupal; Lebrun, Laurie A; Bartkowski, Darian M; Nolan, Thomas G; Norris, Daniel A; Kamran, Ruhi; Brooks, Jennifer; Sergeeva, Maria V; Kirkovsky, Leo; Zhao, Qiang; Kissinger, Charles R

    2008-06-01

    5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. Lead optimization led to the discovery of compound 3a, which displayed potent inhibitory activities in biochemical and replicon assays [IC(50) (1b)60 min), and high ratios of liver to plasma concentrations 12h after a single oral administration to rats.

  6. Hemoglobin derivatives

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003371.htm Hemoglobin derivatives To use the sharing features on this page, please enable JavaScript. Hemoglobin derivatives are altered forms of hemoglobin . Hemoglobin is ...

  7. Sonochemical assisted hydrothermal synthesis of ZnO: Cr nanoparticles loaded activated carbon for simultaneous ultrasound-assisted adsorption of ternary toxic organic dye: Derivative spectrophotometric, optimization, kinetic and isotherm study.

    Science.gov (United States)

    Jamshidi, M; Ghaedi, M; Dashtian, K; Hajati, S; Bazrafshan, A A

    2016-09-01

    Chromium doped zinc oxide nanoparticles (ZnO: Cr-NPs) was synthesized by ultrasonically assisted hydrothermal method and characterized by FE-SEM, XRD and TEM analysis. Subsequently, this composite ultrasonically assisted was deposited on activated carbon (ZnO: Cr-NPs-AC) and used for simultaneous ultrasound-assisted removal of three toxic organic dye namely of malachite green (MG), eosin yellow (EY) and Auramine O (AO). Dyes spectra overlap in mixture (major problem for simultaneous investigation) of this systems was extensively resolved by derivative spectrophotometric method. The magnitude of variables like initial dyes concentration, adsorbent mass and sonication time influence on dyes removal was optimized using small central composite design (CCD) combined with desirability function (DF) approach, while pH was studied by one-a-time approach. The maximized removal percentages at desirability of 0.9740 was set as follow: pH 6.0, 0.019g ZnO: Cr-NPs-AC, 3.9min sonication at 4.5, 4.8 and 4.7mgL(-1) of MG, EY and AO, respectively. Above optimized points lead to achievement of removal percentage of 98.36%, 97.24%, and 99.26% correspond to MG, EY and AO, respectively. ANOVA for each dyes based p-value less than (<0.0001) suggest highly efficiency of CCD model for prediction of data concern to simultaneous removal of these dyes within 95% confidence interval, while their F-value for MG, EY and AO is 935, 800.2, and 551.3, respectively, that confirm low participation of this them in signal. The value of multiple correlation coefficient R(2), adjusted and predicted R(2) for simultaneous removal of MG is 0.9982, 0.9972 and 0.9940, EY is 0.9979, 0.9967 and 0.9930 and for AO is 0.9970, 0.9952 and 0.9939. The adsorption rate well fitted by pseudo second-order and Langmuir model via high, economic and profitable adsorption capacity of 214.0, 189.7 and 211.6mgg(-1) for MG, EY and AO, respectively. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. A New Approach for the Generalized First Derivative and Extension It to the Generalized Second Derivative of Nonsmooth Functions

    OpenAIRE

    Hamid Reza Erfanian; M. H. Noori Skandari; Kamyad, A. V.

    2013-01-01

    In this paper, first derivative of smooth function is defined by the optimal solution of a special optimization problem. In the next step, by using this optimization problem for nonsmooth function, we obtain an approximation for first derivative of nonsmooth function which it is called generalized first derivative. We then extend it to define generalized second derivative for nonsmooth function. Finally, we show the efficiency of our approach by evaluating derivative and generalized first and...

  9. Optimization of water treatment methods for the purification of peat extraction derived runoff: Evaluation of chemical treatment response to variations in incoming water quality using a 2k factorial test design

    Science.gov (United States)

    Heiderscheidt, Elisangela; Ronkanen, Anna-Kaisa; Klöve, Björn

    2013-04-01

    The sustainable use of peatland areas requires measures to minimize and when possible eradicate the identified environmental impacts. The drainage of peatlands and other peat extraction, agriculture and forestry activities are known to increase the leaching of pollutant substances resulting in the eutrophication and siltation of receiving water bodies, causing water quality deterioration. Due to the geochemistry characteristics of peat soils the quality of peatland derived runoff water is known to oscillate with location and also with variations in runoff and peak discharge occurrences. Affordable, simple and reliable purification methods that can purify waters rich in particulates, nutrients and dissolved organic carbon while capable of coping with incoming water quality variations are therefore required. Chemical treatment is considered one of the best available technologies for the purification of peat extraction runoff water in Finland; however, until recently little research had been applied on the development of this treatment method for the purification of non-point source pollution. Chemical purification, using metal salts as coagulant agents, is currently applied in several treatment facilities in Finnish peat extraction sites. Nevertheless, variations in runoff water quality and the lack of development of field process parameters has led to the application of high chemical dosages, significant and undesirable fluctuations in purification efficiency and high metal concentration in the discharging waters. This work aims to develop and optimize the chemical purification method by using high level scientific methods to evaluate the response of the purification process to variations in water quality which are typical of peatland derived runoff. The evaluation of how the purification process responds to these variations is a critical step which will enable the development of preventive measures and optimization of relevant process parameters and thus reduce the

  10. Design Optimization of Internal Flow Devices

    DEFF Research Database (Denmark)

    Madsen, Jens Ingemann

    The power of computational fluid dynamics is boosted through the use of automated design optimization methodologies. The thesis considers both derivative-based search optimization and the use of response surface methodologies.......The power of computational fluid dynamics is boosted through the use of automated design optimization methodologies. The thesis considers both derivative-based search optimization and the use of response surface methodologies....

  11. Designing optimal sampling schemes for field visits

    CSIR Research Space (South Africa)

    Debba, Pravesh

    2008-10-01

    Full Text Available This is a presentation of a statistical method for deriving optimal spatial sampling schemes. The research focuses on ground verification of minerals derived from hyperspectral data. Spectral angle mapper (SAM) and spectral feature fitting (SFF...

  12. Topology optimization of turbulent flows

    DEFF Research Database (Denmark)

    Dilgen, Cetin B.; Dilgen, Sumer B.; Fuhrman, David R.

    2018-01-01

    The aim of this work is to present a fast and viable approach for taking into account turbulence in topology optimization of complex fluid flow systems, without resorting to any simplifying assumptions in the derivation of discrete adjoints. Topology optimization is an iterative gradient...

  13. Supply-Chain Optimization Template

    Science.gov (United States)

    Quiett, William F.; Sealing, Scott L.

    2009-01-01

    The Supply-Chain Optimization Template (SCOT) is an instructional guide for identifying, evaluating, and optimizing (including re-engineering) aerospace- oriented supply chains. The SCOT was derived from the Supply Chain Council s Supply-Chain Operations Reference (SCC SCOR) Model, which is more generic and more oriented toward achieving a competitive advantage in business.

  14. octene derivatives

    Indian Academy of Sciences (India)

    Ultrasonication; trimethylsilyloxy-derivatives; bicyclo[2.2.2]octene; Diels–Alder reaction; crystal structure; C–H. . . O and π...π interactions. 1. ... of silyl- derivatives were studied.8 The structural studies indicated a self-assembly ..... Technology (DST), New Delhi, India for the financial assistance. References. 1. Zhao F, Zhang ...

  15. Financial Derivatives

    DEFF Research Database (Denmark)

    Wigan, Duncan

    2013-01-01

    Contemporary derivatives mark the development of capital and constitute a novel form of ownership. By reconfiguring the temporal, spatial and legal character of ownership derivatives present a substantive challenge to the tax collecting state. While fiscal systems are nationally bounded and inheren...

  16. GAPS IN SUPPORT VECTOR OPTIMIZATION

    Energy Technology Data Exchange (ETDEWEB)

    STEINWART, INGO [Los Alamos National Laboratory; HUSH, DON [Los Alamos National Laboratory; SCOVEL, CLINT [Los Alamos National Laboratory; LIST, NICOLAS [Los Alamos National Laboratory

    2007-01-29

    We show that the stopping criteria used in many support vector machine (SVM) algorithms working on the dual can be interpreted as primal optimality bounds which in turn are known to be important for the statistical analysis of SVMs. To this end we revisit the duality theory underlying the derivation of the dual and show that in many interesting cases primal optimality bounds are the same as known dual optimality bounds.

  17. Global Derivatives

    DEFF Research Database (Denmark)

    Andersen, Torben Juul

    approaches to dealing in the global business environment." - Sharon Brown-Hruska, Commissioner, Commodity Futures Trading Commission, USA. "This comprehensive survey of modern risk management using derivative securities is a fine demonstration of the practical relevance of modern derivatives theory to risk......""In Global Derivatives: A Strategic Risk Management Perspective", Torben Juul Andersen has succeeded to gather in one book a complete and thorough summary and an easy-to-read explanation of all types of derivative instruments and their background, and their use in modern management of risk......." - Steen Parsholt, Chairman and CEO, Aon Nordic Region. "Andersen has done a wonderful job of developing a comprehensive text that deals with risk management in global markets. I would recommend this book to any student or businessman who has a need to better understand the risks and risk management...

  18. Practical methods of optimization

    CERN Document Server

    Fletcher, R

    2013-01-01

    Fully describes optimization methods that are currently most valuable in solving real-life problems. Since optimization has applications in almost every branch of science and technology, the text emphasizes their practical aspects in conjunction with the heuristics useful in making them perform more reliably and efficiently. To this end, it presents comparative numerical studies to give readers a feel for possibile applications and to illustrate the problems in assessing evidence. Also provides theoretical background which provides insights into how methods are derived. This edition offers rev

  19. Sequential optimality conditions for composed convex optimization problems

    Science.gov (United States)

    Bot, Radu Ioan; Csetnek, Ernö Robert; Wanka, Gert

    2008-06-01

    Using a general approach which provides sequential optimality conditions for a general convex optimization problem, we derive necessary and sufficient optimality conditions for composed convex optimization problems. Further, we give sequential characterizations for a subgradient of the precomposition of a K-increasing lower semicontinuous convex function with a K-convex and K-epi-closed (continuous) function, where K is a nonempty convex cone. We prove that several results from the literature dealing with sequential characterizations of subgradients are obtained as particular cases of our results. We also improve the above mentioned statements.

  20. Website Optimization

    CERN Document Server

    King, Andrew

    2008-01-01

    Remember when an optimized website was one that merely didn't take all day to appear? Times have changed. Today, website optimization can spell the difference between enterprise success and failure, and it takes a lot more know-how to achieve success. This book is a comprehensive guide to the tips, techniques, secrets, standards, and methods of website optimization. From increasing site traffic to maximizing leads, from revving up responsiveness to increasing navigability, from prospect retention to closing more sales, the world of 21st century website optimization is explored, exemplified a

  1. Derivative chameleons

    Energy Technology Data Exchange (ETDEWEB)

    Noller, Johannes, E-mail: johannes.noller08@imperial.ac.uk [Theoretical Physics, Blackett Laboratory, Imperial College London, Prince Consort Road, London, SW7 2BZ (United Kingdom)

    2012-07-01

    We consider generalized chameleon models where the conformal coupling between matter and gravitational geometries is not only a function of the chameleon field φ, but also of its derivatives via higher order co-ordinate invariants (such as ∂{sub μ}φ∂{sup μ}φ,□φ,...). Specifically we consider the first such non-trivial conformal factor A(φ,∂{sub μ}φ∂{sup μ}φ). The associated phenomenology is investigated and we show that such theories have a new generic mass-altering mechanism, potentially assisting the generation of a sufficiently large chameleon mass in dense environments. The most general effective potential is derived for such derivative chameleon setups and explicit examples are given. Interestingly this points us to the existence of a purely derivative chameleon protected by a shift symmetry for φ → φ+c. We also discuss potential ghost-like instabilities associated with mass-lifting mechanisms and find another, mass-lowering and instability-free, branch of solutions. This suggests that, barring fine-tuning, stable derivative models are in fact typically anti-chameleons that suppress the field's mass in dense environments. Furthermore we investigate modifications to the thin-shell regime and prove a no-go theorem for chameleon effects in non-conformal geometries of the disformal type.

  2. Optimally cloned binary coherent states

    Science.gov (United States)

    Müller, C. R.; Leuchs, G.; Marquardt, Ch.; Andersen, U. L.

    2017-10-01

    Binary coherent state alphabets can be represented in a two-dimensional Hilbert space. We capitalize this formal connection between the otherwise distinct domains of qubits and continuous variable states to map binary phase-shift keyed coherent states onto the Bloch sphere and to derive their quantum-optimal clones. We analyze the Wigner function and the cumulants of the clones, and we conclude that optimal cloning of binary coherent states requires a nonlinearity above second order. We propose several practical and near-optimal cloning schemes and compare their cloning fidelity to the optimal cloner.

  3. Electricity derivatives

    CERN Document Server

    Aïd, René

    2015-01-01

    Offering a concise but complete survey of the common features of the microstructure of electricity markets, this book describes the state of the art in the different proposed electricity price models for pricing derivatives and in the numerical methods used to price and hedge the most prominent derivatives in electricity markets, namely power plants and swings. The mathematical content of the book has intentionally been made light in order to concentrate on the main subject matter, avoiding fastidious computations. Wherever possible, the models are illustrated by diagrams. The book should allow prospective researchers in the field of electricity derivatives to focus on the actual difficulties associated with the subject. It should also offer a brief but exhaustive overview of the latest techniques used by financial engineers in energy utilities and energy trading desks.

  4. Optimal claim behaviour for vehicle damage insurances

    NARCIS (Netherlands)

    N.P. Dellaert (Nico); J.B.G. Frenk (Hans); L.P. van Rijsoort

    1993-01-01

    textabstractIn this paper we analyse the optimal claim behaviour of a risk sensitive policy holder having a vehicle damage insurance. It is proved that the optimal decision is of the form: to claim for damages only if its amount exceeds a certain limit. Moreover, we also derive the optimal stopping

  5. Optimality Conditions in Vector Optimization

    CERN Document Server

    Jiménez, Manuel Arana; Lizana, Antonio Rufián

    2011-01-01

    Vector optimization is continuously needed in several science fields, particularly in economy, business, engineering, physics and mathematics. The evolution of these fields depends, in part, on the improvements in vector optimization in mathematical programming. The aim of this Ebook is to present the latest developments in vector optimization. The contributions have been written by some of the most eminent researchers in this field of mathematical programming. The Ebook is considered essential for researchers and students in this field.

  6. Structural optimization

    CERN Document Server

    MacBain, Keith M

    2009-01-01

    Intends to supplement the engineer's box of analysis and design tools making optimization as commonplace as the finite element method in the engineering workplace. This title introduces structural optimization and the methods of nonlinear programming such as Lagrange multipliers, Kuhn-Tucker conditions, and calculus of variations.

  7. Optimal Flow.

    Science.gov (United States)

    Norman, Donald A.

    1996-01-01

    Discusses the educational applications of experimental psychologist Mihaly Csikszentmihalyi's theory of peak experience, or optimal flow. Optimal flow refers to the receptive state people achieve when they are engaged in interesting and challenging activity. Includes an insightful critique of multimedia instruction from this perspective. (MJP)

  8. Optimal control of renewable economic resources

    Energy Technology Data Exchange (ETDEWEB)

    Adelani, L.A.

    1987-01-01

    Two main problems are studied: economic optimization, and determination of the optimal age of harvest for an initially immature population which follows a Bertalanffy-type growth law. Conditions are derived on the economic parameters that make maximization of economic rent biologically superior to maximization of sustainable yield. A general equation is derived for the optimal equilibrium biomass size when maximization of present value is the control objective. Also, it is shown that under perfectly elastic demand for the resource, a critical price level exists beyond which economic optimization has to be sacrificed in order to enhance conservation of the resource. An equation is derived whose solution represents the optimal age of harvest for an initially immature population stock. In certain circumstances, analytic forms are obtained for the optimal age of harvest. Some properties of the optimal age of harvest are also investigated.

  9. Complex derivatives

    Science.gov (United States)

    Battiston, Stefano; Caldarelli, Guido; Georg, Co-Pierre; May, Robert; Stiglitz, Joseph

    2013-03-01

    The intrinsic complexity of the financial derivatives market has emerged as both an incentive to engage in it, and a key source of its inherent instability. Regulators now faced with the challenge of taming this beast may find inspiration in the budding science of complex systems.

  10. Optimal Formation Trajectory-Planning Using Parameter Optimization Technique

    Directory of Open Access Journals (Sweden)

    Hyung-Chul Lim

    2004-09-01

    Full Text Available Some methods have been presented to get optimal formation trajectories in the step of configuration or reconfiguration, which subject to constraints of collision avoidance and final configuration. In this study, a method for optimal formation trajectory-planning is introduced in view of fuel/time minimization using parameter optimization technique which has not been applied to optimal trajectory-planning for satellite formation flying. New constraints of nonlinear equality are derived for final configuration and constraints of nonlinear inequality are used for collision avoidance. The final configuration constraints are that three or more satellites should be placed in an equilateral polygon of the circular horizontal plane orbit. Several examples are given to get optimal trajectories based on the parameter optimization problem which subjects to constraints of collision avoidance and final configuration. They show that the introduced method for trajectory-planning is well suited to trajectory design problems of formation flying missions.

  11. Portfolio Optimization

    OpenAIRE

    Frajtova-Michalikova, Katarina; Spuchľakova, Erika; Misankova, Maria

    2015-01-01

    In this paper Portfolio Optimization techniques were used to determine the most favorable investment portfolio. In particular, stock indices of three companies, namely Microsoft Corporation, Christian Dior Fashion House and Shevron Corporation were evaluated. Using this data the amounts invested in each asset when a portfolio is chosen on the efficient frontier were calculated. In addition, the Portfolio with minimum variance, tangency portfolio and optimal Markowitz portfolio are presented.

  12. Efficient Minimax Design of Networks without Using Derivatives

    DEFF Research Database (Denmark)

    Madsen, Kaj; Nielsen, Niels Ole; Schjær-Jacobsen, Hans

    1975-01-01

    A new minimax network optimization algorithm not requiring derivatives has been developed. It is based on successive linear approximations to the nonlinear functions defining the problem. Adequate modeling of distributed parameter circuits for optimization purposes often involves parasitic, etc.,...

  13. Measuring Tax Efficiency: A Tax Optimality Index

    OpenAIRE

    Raimondos-Møller, Pascalis; Woodland, Alan D

    2004-01-01

    This paper introduces an index of tax optimality that measures the distance of some current tax structure from the optimal tax structure in the presence of public goods. In doing so, we derive a [0, 1] number that reveals immediately how far the current tax configuration is from the optimal one and, thereby, the degree of efficiency of a tax system. We call this number the Tax Optimality Index. We show how the basic method can be altered in order to derive a revenue equivale...

  14. The Theory of Optimal Taxation

    DEFF Research Database (Denmark)

    Sørensen, Peter Birch

    The theory of optimal taxation has often been criticized for being of little practical policy relevance, due to a lack of robust theoretical results. This paper argues that recent advances in optimal tax theory has made that theory easier to apply and may help to explain some current trends...... in international tax policy. Covering the taxation of labour income and capital income as well as indirect taxation, the paper also illustrates how some of the key results in optimal tax theory may be derived in a simple, heuristic manner....

  15. Optimal operation of batch membrane processes

    CERN Document Server

    Paulen, Radoslav

    2016-01-01

    This study concentrates on a general optimization of a particular class of membrane separation processes: those involving batch diafiltration. Existing practices are explained and operational improvements based on optimal control theory are suggested. The first part of the book introduces the theory of membrane processes, optimal control and dynamic optimization. Separation problems are defined and mathematical models of batch membrane processes derived. The control theory focuses on problems of dynamic optimization from a chemical-engineering point of view. Analytical and numerical methods that can be exploited to treat problems of optimal control for membrane processes are described. The second part of the text builds on this theoretical basis to establish solutions for membrane models of increasing complexity. Each chapter starts with a derivation of optimal operation and continues with case studies exemplifying various aspects of the control problems under consideration. The authors work their way from th...

  16. Topology optimization

    DEFF Research Database (Denmark)

    Bendsøe, Martin P.; Sigmund, Ole

    2007-01-01

    Taking as a starting point a design case for a compliant mechanism (a force inverter), the fundamental elements of topology optimization are described. The basis for the developments is a FEM format for this design problem and emphasis is given to the parameterization of design as a raster image...

  17. Optimal transport

    CERN Document Server

    Eckmann, B

    2008-01-01

    At the close of the 1980s, the independent contributions of Yann Brenier, Mike Cullen and John Mather launched a revolution in the venerable field of optimal transport founded by G Monge in the 18th century, which has made breathtaking forays into various other domains of mathematics ever since. The author presents a broad overview of this area.

  18. The Option Value in Timing Derivative Trades

    NARCIS (Netherlands)

    Drost, Feico; van der Heijden, T.G.E.; Werker, Bas

    Risk-neutral traders executing derivative trades on behalf of portfolio managers maximize their expected profit compared to trading at pre-determined times by timing trades, using the quickly changing risk exposures of derivative baskets. The optimal order submission strategy is a sequence of stop

  19. Optimal Explicit Binomial Confidence Interval with Guaranteed Coverage Probability

    OpenAIRE

    Chen, Xinjia

    2008-01-01

    In this paper, we develop an approach for optimizing the explicit binomial confidence interval recently derived by Chen et al. The optimization reduces conservativeness while guaranteeing prescribed coverage probability.

  20. Optimal asymptotic cloning machines

    Science.gov (United States)

    Chiribella, Giulio; Yang, Yuxiang

    2014-06-01

    We pose the question whether the asymptotic equivalence between quantum cloning and quantum state estimation, valid at the single-clone level, still holds when all clones are examined globally. We conjecture that the answer is affirmative and present a large amount of evidence supporting our conjecture, developing techniques to derive optimal asymptotic cloners and proving their equivalence with estimation in virtually all scenarios considered in the literature. Our analysis covers the case of arbitrary finite sets of states, arbitrary families of coherent states, arbitrary phase- and multiphase-covariant sets of states, and two-qubit maximally entangled states. In all these examples we observe that the optimal asymptotic cloners enjoy a universality property, consisting in the fact that scaling of their fidelity does not depend on the specific details of the input states, but only on the number of free parameters needed to specify them.

  1. Fractional Derivative as Fractional Power of Derivative

    OpenAIRE

    Tarasov, Vasily E.

    2007-01-01

    Definitions of fractional derivatives as fractional powers of derivative operators are suggested. The Taylor series and Fourier series are used to define fractional power of self-adjoint derivative operator. The Fourier integrals and Weyl quantization procedure are applied to derive the definition of fractional derivative operator. Fractional generalization of concept of stability is considered.

  2. Optimizing production under uncertainty

    DEFF Research Database (Denmark)

    Rasmussen, Svend

    This Working Paper derives criteria for optimal production under uncertainty based on the state-contingent approach (Chambers and Quiggin, 2000), and discusses po-tential problems involved in applying the state-contingent approach in a normative context. The analytical approach uses the concept...... of state-contingent production functions and a definition of inputs including both sort of input, activity and alloca-tion technology. It also analyses production decisions where production is combined with trading in state-contingent claims such as insurance contracts. The final part discusses...

  3. Optimal Provision of Public Goods

    DEFF Research Database (Denmark)

    Kreiner, Claus Thustrup; Verdelin, Nicolaj

    2012-01-01

    The standard approach to the optimal provision of public goods highlights the importance of distortionary taxation and distributional concerns. A new approach neutralizes distributional concerns by adjusting the income tax schedule. We demonstrate that both approaches are derived from the same...

  4. Optimal Admission to Higher Education

    Science.gov (United States)

    Albaek, Karsten

    2017-01-01

    This paper analyses admission decisions when students from different high school tracks apply for admission to university programmes. I derive a criterion that is optimal in the sense that it maximizes the graduation rates of the university programmes. The paper contains an empirical analysis that documents the relevance of theory and illustrates…

  5. Optimal control

    CERN Document Server

    Aschepkov, Leonid T; Kim, Taekyun; Agarwal, Ravi P

    2016-01-01

    This book is based on lectures from a one-year course at the Far Eastern Federal University (Vladivostok, Russia) as well as on workshops on optimal control offered to students at various mathematical departments at the university level. The main themes of the theory of linear and nonlinear systems are considered, including the basic problem of establishing the necessary and sufficient conditions of optimal processes. In the first part of the course, the theory of linear control systems is constructed on the basis of the separation theorem and the concept of a reachability set. The authors prove the closure of a reachability set in the class of piecewise continuous controls, and the problems of controllability, observability, identification, performance and terminal control are also considered. The second part of the course is devoted to nonlinear control systems. Using the method of variations and the Lagrange multipliers rule of nonlinear problems, the authors prove the Pontryagin maximum principle for prob...

  6. Optimization Problems

    Directory of Open Access Journals (Sweden)

    Yaping Hu

    2015-01-01

    the nonsmooth convex optimization problem. First, by using Moreau-Yosida regularization, we convert the original objective function to a continuously differentiable function; then we use approximate function and gradient values of the Moreau-Yosida regularization to substitute the corresponding exact values in the algorithm. The global convergence is proved under suitable assumptions. Numerical experiments are presented to show the effectiveness of this algorithm.

  7. Numerical Optimization

    Science.gov (United States)

    1992-12-01

    optimization (as opposed to the so-called "pivotal" methods, such as the simplex method for linear pro- gramming), with special consideration for the...to be of the same order of one step of Karmarkar’s algorithm. While one step of the classical simplex algorithm [13] for linear pro- gramming is much...memoria d; Carlo Cartaneo, maestro ed amkco RIASSUNTO - Si considera un nuovo metodo per la risoluzione numeraca eta di sistern. di eqiuazioni non lineari

  8. Optimal Diversification

    OpenAIRE

    Gomes, Joao F; Livdan, Dmitry

    2002-01-01

    In this Paper we show that the main empirical findings about firm diversification and performance are actually consistent with the optimal behavior of a firm that maximizes shareholder value. In our model, diversification allows a firm to explore better productive opportunities while taking advantage of economies of scale. The dynamic structure of our model allows us to examine several aspects of the relationship between firm diversification and performance in a very general setting.

  9. On $n$-derivations

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Sattari

    2016-06-01

    Full Text Available In this article, the notion of $n-$derivation is introduced for all integers $ngeq 2$. Although all derivations are $n-$derivations,  in general these notions are not equivalent. Some properties of ordinary derivations are  investigated for $n-$derivations. Also, we show that under certain mild condition  $n-$derivations are derivations.

  10. Algae Derived Biofuel

    Energy Technology Data Exchange (ETDEWEB)

    Jahan, Kauser [Rowan Univ., Glassboro, NJ (United States)

    2015-03-31

    One of the most promising fuel alternatives is algae biodiesel. Algae reproduce quickly, produce oils more efficiently than crop plants, and require relatively few nutrients for growth. These nutrients can potentially be derived from inexpensive waste sources such as flue gas and wastewater, providing a mutual benefit of helping to mitigate carbon dioxide waste. Algae can also be grown on land unsuitable for agricultural purposes, eliminating competition with food sources. This project focused on cultivating select algae species under various environmental conditions to optimize oil yield. Membrane studies were also conducted to transfer carbon di-oxide more efficiently. An LCA study was also conducted to investigate the energy intensive steps in algae cultivation.

  11. Sampling scheme optimization from hyperspectral data

    NARCIS (Netherlands)

    Debba, P.

    2006-01-01

    This thesis presents statistical sampling scheme optimization for geo-environ-menta] purposes on the basis of hyperspectral data. It integrates derived products of the hyperspectral remote sensing data into individual sampling schemes. Five different issues are being dealt with.First, the optimized

  12. Optimal Changepoint Tests for Normal Linear Regression

    OpenAIRE

    Donald W.K. Andrews; Inpyo Lee; Werner Ploberger

    1992-01-01

    This paper determines a class of finite sample optimal tests for the existence of a changepoint at an unknown time in a normal linear multiple regression model with known variance. Optimal tests for multiple changepoints are also derived. Power comparisons of several tests are provided based on simulations.

  13. Soap-bubble Optimization of Gaits

    OpenAIRE

    Ramasamy, Suresh; Hatton, Ross L.

    2016-01-01

    In this paper, we present a geometric variational algorithm for optimizing the gaits of kinematic locomoting systems. The dynamics of this algorithm are analogous to the physics of a soap bubble, with the system's Lie bracket supplying an "inflation pressure" that is balanced by a "surface tension" term derived from a Riemannian metric on the system's shape space. We demonstrate this optimizer on a variety of system geometries (including Purcell's swimmer) and for optimization criteria that i...

  14. Discrete optimization

    CERN Document Server

    Parker, R Gary

    1988-01-01

    This book treats the fundamental issues and algorithmic strategies emerging as the core of the discipline of discrete optimization in a comprehensive and rigorous fashion. Following an introductory chapter on computational complexity, the basic algorithmic results for the two major models of polynomial algorithms are introduced--models using matroids and linear programming. Further chapters treat the major non-polynomial algorithms: branch-and-bound and cutting planes. The text concludes with a chapter on heuristic algorithms.Several appendixes are included which review the fundamental ideas o

  15. Unconstrained Optimization

    DEFF Research Database (Denmark)

    Frandsen, P. E.; Jonasson, K.; Nielsen, Hans Bruun

    1999-01-01

    an introduction to algorithms for unconstrained optimization. We present Conjugate Gradient, Damped Newton and Quasi Newton methods together with the relevant theoretical background. The reader is assumed to be familiar with algorithms for solving linear and nonlinear system of equations, at a level corresponding...... to an introductory course in numerical analysis. The algorithms presented in the note appear in any good program library, and implementations can be found via GAMS (Guide to Available Mathematical Software) at the Internet address http://gams.nist.gov The examples in the note were computed in Matlab. The programs...

  16. Multiobjective Optimization and Phase Transitions

    CERN Document Server

    Seoane, Luís F

    2015-01-01

    Many complex systems obey to optimality conditions that are usually not simple. Conflicting traits often interact making a Multi Objective Optimization (MOO) approach necessary. Recent MOO research on complex systems report about the Pareto front (optimal designs implementing the best trade-off) in a qualitative manner. Meanwhile, research on traditional Simple Objective Optimization (SOO) often finds phase transitions and critical points. We summarize a robust framework that accounts for phase transitions located through SOO techniques and indicates what MOO features resolutely lead to phase transitions. These appear determined by the shape of the Pareto front, which at the same time is deeply related to the thermodynamic Gibbs surface. Indeed, thermodynamics can be written as an MOO from where its phase transitions can be parsimoniously derived; suggesting that the similarities between transitions in MOO-SOO and Statistical Mechanics go beyond mere coincidence.

  17. Optimization methods in structural design

    CERN Document Server

    Rothwell, Alan

    2017-01-01

    This book offers an introduction to numerical optimization methods in structural design. Employing a readily accessible and compact format, the book presents an overview of optimization methods, and equips readers to properly set up optimization problems and interpret the results. A ‘how-to-do-it’ approach is followed throughout, with less emphasis at this stage on mathematical derivations. The book features spreadsheet programs provided in Microsoft Excel, which allow readers to experience optimization ‘hands-on.’ Examples covered include truss structures, columns, beams, reinforced shell structures, stiffened panels and composite laminates. For the last three, a review of relevant analysis methods is included. Exercises, with solutions where appropriate, are also included with each chapter. The book offers a valuable resource for engineering students at the upper undergraduate and postgraduate level, as well as others in the industry and elsewhere who are new to these highly practical techniques.Whi...

  18. Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.

    Science.gov (United States)

    Smaill, Jeff B; Gonzales, Andrea J; Spicer, Julie A; Lee, Helen; Reed, Jessica E; Sexton, Karen; Althaus, Irene W; Zhu, Tong; Black, Shannon L; Blaser, Adrian; Denny, William A; Ellis, Paul A; Fakhoury, Stephen; Harvey, Patricia J; Hook, Ken; McCarthy, Florence O J; Palmer, Brian D; Rivault, Freddy; Schlosser, Kevin; Ellis, Teresa; Thompson, Andrew M; Trachet, Erin; Winters, R Thomas; Tecle, Haile; Bridges, Alexander

    2016-09-08

    Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of quinazoline- and pyrido[3,4-d]pyrimidine-based analogues of the irreversible pan-erbB inhibitor, canertinib. Cyclic amine bearing crotonamides were determined to provide rapid inhibition of cellular erbB1 autophosphorylation and good metabolic stability in liver microsome and hepatocyte assays. The influence of 4-anilino substitution on pan-erbB inhibitory potency was investigated. Several anilines were identified as providing potent, reversible pan-erbB inhibition. Optimum 4- and 6-substituents with known 7-substituents provided preferred irreversible inhibitors for pharmacodynamic testing in vivo. Quinazoline 54 and pyrido[3,4-d]pyrimidine 71 were identified as clearly superior to canertinib. Both compounds possess a piperidinyl crotonamide Michael acceptor and a 3-chloro-4-fluoroaniline, indicating these as optimized 6- and 4-substituents, respectively. Pharmacokinetic comparison of compounds 54 and 71 across three species selected compound 54 as the preferred candidate. Compound 54 (PF-00299804) has been assigned the nomenclature of dacomitinib and is currently under clinical evaluation.

  19. Aircraft Trajectory Optimization Using Parametric Optimization Theory

    OpenAIRE

    Valenzuela Romero, Alfonso

    2012-01-01

    In this thesis, a study of the optimization of aircraft trajectories using parametric optimization theory is presented. To that end, an approach based on the use of predefined trajectory patterns and parametric optimization is proposed. The trajectory pat

  20. Toward a feline-optimized culture medium: impact of ions, carbohydrates, essential amino acids, vitamins, and serum on development and metabolism of in vitro fertilization-derived feline embryos relative to embryos grown in vivo.

    Science.gov (United States)

    Herrick, Jason R; Bond, Jennifer B; Magarey, Genevieve M; Bateman, Helen L; Krisher, Rebecca L; Dunford, Susan A; Swanson, William F

    2007-05-01

    The objective of this study was to define the physiologic needs of domestic cat embryos to facilitate development of a feline-specific culture medium. In a series of factorial experiments, in vivo-matured oocytes (n = 2040) from gonadotropin-treated domestic cats were inseminated in vitro to generate embryos (n = 1464) for culture. In the initial study, concentrations of NaCl (100.0 vs. 120.0 mM), KCl (4.0 vs. 8.0 mM), KH(2)PO(4) (0.25 vs. 1.0 mM), and the ratio of CaCl(2) to MgSO(4)-7H(2)O (1.0:2.0 mM vs. 2.0:1.0 mM) in the medium were evaluated during Days 1-6 (Day 0: oocyte recovery and in vitro fertilization [IVF]) of culture. Subsequent experiments assessed the effects of varying concentrations of carbohydrate (glucose, 1.5, 3.0, or 6.0 mM; l-lactate, 3.0, 6.0, or 12.0 mM; and pyruvate, 0.1 or 1.0 mM) and essential amino acids (EAAs; 0, 0.5, or 1.0x) in the medium during Days 1-3 and Days 3-6 of culture. Inclusion of vitamins (0 vs. 1.0x) and fetal calf serum (FCS; 0 vs. 5% [v/v]) in the medium also was evaluated during Days 3-6. Development and metabolism of IVF embryos on Day 3 or Day 6 were compared to age-matched in vivo embryos recovered from naturally mated queens. A feline-optimized culture medium (FOCM) was formulated based on these results (100.0 mM NaCl, 8.0 mM KCl, 1.0 mM KH(2)PO(4), 2.0 mM CaCl(2), 1.0 mM MgSO(4), 1.5 mM glucose, 6.0 mM L-lactate, 0.1 mM pyruvate, and 0x EAAs with 25.0 mM NaHCO(3), 1.0 mM alanyl-glutamine, 0.1 mM taurine, and 1.0x nonessential amino acids) with 0.4% (w/v) BSA from Days 0-3 and 5% FCS from Days 3-6. Using this medium, ~70% of cleaved embryos developed into blastocysts with profiles of carbohydrate metabolism similar to in vivo embryos. Our results suggest that feline embryos have stage-specific responses to carbohydrates and are sensitive to EAAs but are still reliant on one or more unidentified components of FCS for optimal blastocyst development.

  1. Optimizing Water Exchange Rates and Rotational Mobility for High-Relaxivity of a Novel Gd-DO3A Derivative Complex Conjugated to Inulin as Macromolecular Contrast Agents for MRI.

    Science.gov (United States)

    Granato, Luigi; Vander Elst, Luce; Henoumont, Celine; Muller, Robert N; Laurent, Sophie

    2018-02-01

    Thanks to the understanding of the relationships between the residence lifetime τ M of the coordinated water molecules to macrocyclic Gd-complexes and the rotational mobility τ R of these structures, and according to the theory for paramagnetic relaxation, it is now possible to design macromolecular contrast agents with enhanced relaxivities by optimizing these two parameters through ligand structural modification. We succeeded in accelerating the water exchange rate by inducing steric compression around the water binding site, and by removing the amide function from the DOTA-AA ligand [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(p-aminoanilide)] (L) previously designed. This new ligand 10[2(1-oxo-1-p-propylthioureidophenylpropyl]-1,4,7,10-tetraazacyclodecane-1,4,7-tetraacetic acid (L 1 ) was then covalently conjugated to API [O-(aminopropyl)inulin] to get the complex API-(GdL 1 )x with intent to slow down the rotational correlation time (τ R ) of the macromolecular complex. The evaluation of the longitudinal relaxivity at different magnetic fields and the study of the 17 O-NMR at variable temperature of the low-molecular-weight compound (GdL 1 ) showed a slight decrease of the τ M value (τM310 = 331 ns vs. τM310 = 450 ns for the GdL complex). Consequently to the increase of the size of the API-(GdL 1 )x complex, the rotational correlation time becomes about 360 times longer compared to the monomeric GdL 1 complex (τ R  = 33,700 ps), which results in an enhanced proton relaxivity. © 2018 Wiley-VHCA AG, Zurich, Switzerland.

  2. Enantioselective Michael Addition of Malonates to Chalcone Derivatives Catalyzed by Dipeptide-derived Multifunctional Phosphonium Salts.

    Science.gov (United States)

    Cao, Dongdong; Fang, Guosheng; Zhang, Jiaxing; Wang, Hongyu; Zheng, Changwu; Zhao, Gang

    2016-10-21

    Highly enantioselective Michael addition of malonates to enones catalyzed by dipeptide-derived multifunctional phosphonium salts has been developed. The newly established catalytic system was characterized with its wide substrate scope featured with aliphatic aldehyde-derived enones and substituted malonates. The gram scale-up synthesis of adducts can also be successfully achieved under optimal conditions with both excellent yield and enantioselectivity.

  3. Optimal produktion

    Directory of Open Access Journals (Sweden)

    Öje Danell

    1999-04-01

    Full Text Available Optimal Production in Reindeer Husbandry.There are three ways to optimize the reindeer herd: 1 Adjusting the reindeer number to pasture resources. 2 Keeping as many productive animals in the herd as possible through slaughter. 3 Increasing the herd quality through selection.Renhjorden bör optimeras så att den fungerar som en "skördeapparat" for bete och lämnar största möjliga bidrag till försörjningen för dem som lever av renskötsel. Det finns minst tre sätt att optimera renhjorden, nämligen (1 anpassning av djurantalet till betesresurserna så att djurens kondition och därmed produktiviteten kan bibehållas på hög nivå, (2 utforma renhjordens struktur med hjalp av slaktuttaget så att den innehåller så stor andel produktiva djur som möjligt, och (3 förbättra djurmaterialets produktionsmässiga kvalitet genom urval baserat på registrerad produktion. Betesanpassningen är den mest grundläggande åtgärden och ger den snabbaste effekten. Även hjordstrukturering är en åtgärd som ger relativt snabb effekt och som dessutom kan beslutas och utforas av den enskilde djuraägaren utan att störa den kollektiva renskötseln. Urval är en åtgärd som ger effekt först på längre sikt och därför kräver en konsekvent insats under en längre tid.

  4. Thermodynamic Metrics and Optimal Paths

    Energy Technology Data Exchange (ETDEWEB)

    Sivak, David; Crooks, Gavin

    2012-05-08

    A fundamental problem in modern thermodynamics is how a molecular-scale machine performs useful work, while operating away from thermal equilibrium without excessive dissipation. To this end, we derive a friction tensor that induces a Riemannian manifold on the space of thermodynamic states. Within the linear-response regime, this metric structure controls the dissipation of finite-time transformations, and bestows optimal protocols with many useful properties. We discuss the connection to the existing thermodynamic length formalism, and demonstrate the utility of this metric by solving for optimal control parameter protocols in a simple nonequilibrium model.

  5. Model Risk in Portfolio Optimization

    Directory of Open Access Journals (Sweden)

    David Stefanovits

    2014-08-01

    Full Text Available We consider a one-period portfolio optimization problem under model uncertainty. For this purpose, we introduce a measure of model risk. We derive analytical results for this measure of model risk in the mean-variance problem assuming we have observations drawn from a normal variance mixture model. This model allows for heavy tails, tail dependence and leptokurtosis of marginals. The results show that mean-variance optimization is seriously compromised by model uncertainty, in particular, for non-Gaussian data and small sample sizes. To mitigate these shortcomings, we propose a method to adjust the sample covariance matrix in order to reduce model risk.

  6. Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases

    Energy Technology Data Exchange (ETDEWEB)

    Premkumar, Lakshmanane, E-mail: p.lakshmanane@imb.uq.edu.au; Heras, Begoña; Duprez, Wilko; Walden, Patricia; Halili, Maria; Kurth, Fabian; Fairlie, David P.; Martin, Jennifer L., E-mail: p.lakshmanane@imb.uq.edu.au [University of Queensland, St Lucia, QLD 4067 (Australia)

    2013-10-01

    The gene product of M. tuberculosis Rv2969c is shown to be a disulfide oxidase enzyme that has a canonical DsbA-like fold with novel structural and functional characteristics. The bacterial disulfide machinery is an attractive molecular target for developing new antibacterials because it is required for the production of multiple virulence factors. The archetypal disulfide oxidase proteins in Escherichia coli (Ec) are DsbA and DsbB, which together form a functional unit: DsbA introduces disulfides into folding proteins and DsbB reoxidizes DsbA to maintain it in the active form. In Mycobacterium tuberculosis (Mtb), no DsbB homologue is encoded but a functionally similar but structurally divergent protein, MtbVKOR, has been identified. Here, the Mtb protein Rv2969c is investigated and it is shown that it is the DsbA-like partner protein of MtbVKOR. It is found that it has the characteristic redox features of a DsbA-like protein: a highly acidic catalytic cysteine, a highly oxidizing potential and a destabilizing active-site disulfide bond. Rv2969c also has peptide-oxidizing activity and recognizes peptide segments derived from the periplasmic loops of MtbVKOR. Unlike the archetypal EcDsbA enzyme, Rv2969c has little or no activity in disulfide-reducing and disulfide-isomerase assays. The crystal structure of Rv2969c reveals a canonical DsbA fold comprising a thioredoxin domain with an embedded helical domain. However, Rv2969c diverges considerably from other DsbAs, including having an additional C-terminal helix (H8) that may restrain the mobility of the catalytic helix H1. The enzyme is also characterized by a very shallow hydrophobic binding surface and a negative electrostatic surface potential surrounding the catalytic cysteine. The structure of Rv2969c was also used to model the structure of a paralogous DsbA-like domain of the Ser/Thr protein kinase PknE. Together, these results show that Rv2969c is a DsbA-like protein with unique properties and a limited

  7. [SIAM conference on optimization

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-10

    Abstracts are presented of 63 papers on the following topics: large-scale optimization, interior-point methods, algorithms for optimization, problems in control, network optimization methods, and parallel algorithms for optimization problems.

  8. Applications of automatic differentiation in topology optimization

    DEFF Research Database (Denmark)

    Nørgaard, Sebastian A.; Sagebaum, Max; Gauger, Nicolas R.

    2017-01-01

    The goal of this article is to demonstrate the applicability and to discuss the advantages and disadvantages of automatic differentiation in topology optimization. The technique makes it possible to wholly or partially automate the evaluation of derivatives for optimization problems and is demons......The goal of this article is to demonstrate the applicability and to discuss the advantages and disadvantages of automatic differentiation in topology optimization. The technique makes it possible to wholly or partially automate the evaluation of derivatives for optimization problems...... and is demonstrated on two separate, previously published types of problems in topology optimization. Two separate software packages for automatic differentiation, CoDiPack and Tapenade are considered, and their performance and usability trade-offs are discussed and compared to a hand coded adjoint gradient...

  9. Optimal Provision of Public Goods

    DEFF Research Database (Denmark)

    Kreiner, Claus Thustrup; Verdelin, Nicolaj

    2009-01-01

    There currently exist two competing approaches in the literature on the optimal provision of public goods. The standard approach highlights the importance of distortionary taxation and distributional concerns. The new approach neutralizes distributional concerns by adjusting the non-linear income...... tax, and finds that this reinvigorates the simple Samuelson rule when preferences are separable in goods and leisure. We provide a synthesis by demonstrating that both approaches derive from the same basic formula. We further develop the new approach by deriving a general, intuitive formula...

  10. Portfolio Optimization and Mortgage Choice

    Directory of Open Access Journals (Sweden)

    Maj-Britt Nordfang

    2017-01-01

    Full Text Available This paper studies the optimal mortgage choice of an investor in a simple bond market with a stochastic interest rate and access to term life insurance. The study is based on advances in stochastic control theory, which provides analytical solutions to portfolio problems with a stochastic interest rate. We derive the optimal portfolio of a mortgagor in a simple framework and formulate stylized versions of mortgage products offered in the market today. This allows us to analyze the optimal investment strategy in terms of optimal mortgage choice. We conclude that certain extreme investors optimally choose either a traditional fixed rate mortgage or an adjustable rate mortgage, while investors with moderate risk aversion and income prefer a mix of the two. By matching specific investor characteristics to existing mortgage products, our study provides a better understanding of the complex and yet restricted mortgage choice faced by many household investors. In addition, the simple analytical framework enables a detailed analysis of how changes to market, income and preference parameters affect the optimal mortgage choice.

  11. Pareto optimality in infinite horizon linear quadratic differential games

    NARCIS (Netherlands)

    Reddy, P.V.; Engwerda, J.C.

    2013-01-01

    In this article we derive conditions for the existence of Pareto optimal solutions for linear quadratic infinite horizon cooperative differential games. First, we present a necessary and sufficient characterization for Pareto optimality which translates to solving a set of constrained optimal

  12. Real-Time Optimization in Complex Stochastic Environment

    Science.gov (United States)

    2015-06-24

    proved that elliptical trajectories outperform linear ones [41]. With this motivation, we formulated a parametric optimization problem in which we seek...to determine such optimal elliptical trajectories and then showed that the problem can again be solved using IPA to obtain performance gradients on...we have incorporated a stochastic comparison algorithm for deriving globally optimal elliptical trajectories . Our approach allows for

  13. Optimality conditions for the numerical solution of optimization problems with PDE constraints :

    Energy Technology Data Exchange (ETDEWEB)

    Aguilo Valentin, Miguel Alejandro; Ridzal, Denis

    2014-03-01

    A theoretical framework for the numerical solution of partial di erential equation (PDE) constrained optimization problems is presented in this report. This theoretical framework embodies the fundamental infrastructure required to e ciently implement and solve this class of problems. Detail derivations of the optimality conditions required to accurately solve several parameter identi cation and optimal control problems are also provided in this report. This will allow the reader to further understand how the theoretical abstraction presented in this report translates to the application.

  14. Shearlets and Optimally Sparse Approximations

    DEFF Research Database (Denmark)

    Kutyniok, Gitta; Lemvig, Jakob; Lim, Wang-Q

    2012-01-01

    Multivariate functions are typically governed by anisotropic features such as edges in images or shock fronts in solutions of transport-dominated equations. One major goal both for the purpose of compression as well as for an efficient analysis is the provision of optimally sparse approximations...... of such functions. Recently, cartoon-like images were introduced in 2D and 3D as a suitable model class, and approximation properties were measured by considering the decay rate of the $L^2$ error of the best $N$-term approximation. Shearlet systems are to date the only representation system, which provide...... optimally sparse approximations of this model class in 2D as well as 3D. Even more, in contrast to all other directional representation systems, a theory for compactly supported shearlet frames was derived which moreover also satisfy this optimality benchmark. This chapter shall serve as an introduction...

  15. Optimal Computing Budget Allocation for Particle Swarm Optimization in Stochastic Optimization.

    Science.gov (United States)

    Zhang, Si; Xu, Jie; Lee, Loo Hay; Chew, Ek Peng; Wong, Wai Peng; Chen, Chun-Hung

    2017-04-01

    Particle Swarm Optimization (PSO) is a popular metaheuristic for deterministic optimization. Originated in the interpretations of the movement of individuals in a bird flock or fish school, PSO introduces the concept of personal best and global best to simulate the pattern of searching for food by flocking and successfully translate the natural phenomena to the optimization of complex functions. Many real-life applications of PSO cope with stochastic problems. To solve a stochastic problem using PSO, a straightforward approach is to equally allocate computational effort among all particles and obtain the same number of samples of fitness values. This is not an efficient use of computational budget and leaves considerable room for improvement. This paper proposes a seamless integration of the concept of optimal computing budget allocation (OCBA) into PSO to improve the computational efficiency of PSO for stochastic optimization problems. We derive an asymptotically optimal allocation rule to intelligently determine the number of samples for all particles such that the PSO algorithm can efficiently select the personal best and global best when there is stochastic estimation noise in fitness values. We also propose an easy-to-implement sequential procedure. Numerical tests show that our new approach can obtain much better results using the same amount of computational effort.

  16. Reliability Based Optimization of Structural Systems

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    1987-01-01

    The optimization problem to design structural systems such that the reliability is satisfactory during the whole lifetime of the structure is considered in this paper. Some of the quantities modelling the loads and the strength of the structure are modelled as random variables. The reliability....... For these optimization problems it is described how a sensitivity analysis can be performed. Next, new optimization procedures to solve the optimization problems are presented. Two of these procedures solve the system reliability based optimization problem sequentially using quasi-analytical derivatives. Finally...... is estimated using first. order reliability methods ( FORM ). The design problem is formulated as the optimization problem to minimize a given cost function such that the reliability of the single elements satisfies given requirements or such that the systems reliability satisfies a given requirement...

  17. On the Optimal Dynamic Control Strategy of Disruptive Computer Virus

    Directory of Open Access Journals (Sweden)

    Jichao Bi

    2017-01-01

    Full Text Available Disruptive computer viruses have inflicted huge economic losses. This paper addresses the development of a cost-effective dynamic control strategy of disruptive viruses. First, the development problem is modeled as an optimal control problem. Second, a criterion for the existence of an optimal control is given. Third, the optimality system is derived. Next, some examples of the optimal dynamic control strategy are presented. Finally, the performance of actual dynamic control strategies is evaluated.

  18. Interest rate derivatives

    DEFF Research Database (Denmark)

    Svenstrup, Mikkel

    This Ph.D. thesis consists of four self-contained essays on valuation of interest rate derivatives. In particular derivatives related to management of interest rate risk care are considered.......This Ph.D. thesis consists of four self-contained essays on valuation of interest rate derivatives. In particular derivatives related to management of interest rate risk care are considered....

  19. HYBRID GREY WOLF OPTIMIZATION-PATTERN SEARCH (hGWO-PS) OPTIMIZED 2DOF-PID CONTROLLERS FOR LOAD FREQUENCY CONTROL (LFC) IN INTERCONNECTED THERMAL POWER PLANTS

    National Research Council Canada - National Science Library

    V, Soni; G, Parmar; M, Kumar; S, Panda

    2016-01-01

    The combination of Grey Wolf Optimization and Pattern Search Technique (hGWO-PS) has been introduced to optimize the parameters of two Degree of Freedom Proportional-Integral-Derivative Controller (2DOF-PID...

  20. Generalized Riemann derivative

    Directory of Open Access Journals (Sweden)

    Sorin Radulescu

    2013-03-01

    Full Text Available Initiated by Marshall Ash in 1966, the study of generalized Riemann derivative draw significant attention of the mathematical community and numerous studies where carried out since then. One of the major areas that benefits from these developments is the numerical analysis, as the use of generalized Riemann derivatives leads to solving a wider class of problems that are not solvable with the classical tools. This article studies the generalized Riemann derivative and its properties and establishes relationships between Riemann generalized derivative and the classical one. The existence of classical derivative implies the existence of the Riemann generalized derivative, and we study conditions necessary for the generalized Riemann derivative to imply the existence of the classical derivative. Furthermore, we provide conditions on the generalized Riemann derivative that are sufficient for the existence of the classical derivative.

  1. Characterization of sugar beet pulp derived oligosaccharides

    NARCIS (Netherlands)

    Leijdekkers, M.

    2015-01-01

    Abstract This thesis aimed at characterizing complex mixtures of sugar beet pulp derived oligosaccharides, in order to be able to monitor and optimize the enzymatic saccharification of sugar beet pulp. Hydrophilic interaction chromatography with on-line evaporative light scattering

  2. Deriving optimal exploration target zones on mineral prospectivity maps

    CSIR Research Space (South Africa)

    Debba, Pravesh

    2008-08-01

    Full Text Available |D) is the weight of evidence for the absence of Bt. The statistical significance of the weights can be determined based on their variances, which are approximated from Bishop, Fienberg and Holland (1975) as s2(W+) = 1 N(Bt ∩D) + 1 N(Bt ∩D) and s2(W−) = 1... N(Bt ∩D) + 1 N(Bt ∩D) , (5) where N(·) denotes the number of counts; for example, N(Bt ∩D) is the number of mineral deposit occurrences in the presence of binary pattern Bt. Once the weights W+ and W− are determined from Equations 3 and 4...

  3. Synthetic Bioluminescent Coelenterazine Derivatives.

    Science.gov (United States)

    Nishihara, Ryo; Citterio, Daniel; Suzuki, Koji

    2016-01-01

    The development of coelenterazine (CTZ) derivatives resulting in superior optical characteristics is an efficient method to extend the range of its possible applications. Here, we describe the synthesis of three C-6 substituted CTZ derivatives retaining the recognition by Renilla luciferase (RLuc) and its derivatives. The novel derivatives are useful as bright blue-shifted CTZ derivatives, which can be used as an alternative to hitherto reported compound DeepBlueC™.

  4. Optimization modeling with spreadsheets

    CERN Document Server

    Baker, Kenneth R

    2015-01-01

    An accessible introduction to optimization analysis using spreadsheets Updated and revised, Optimization Modeling with Spreadsheets, Third Edition emphasizes model building skills in optimization analysis. By emphasizing both spreadsheet modeling and optimization tools in the freely available Microsoft® Office Excel® Solver, the book illustrates how to find solutions to real-world optimization problems without needing additional specialized software. The Third Edition includes many practical applications of optimization models as well as a systematic framework that il

  5. Constraint Optimization Literature Review

    Science.gov (United States)

    2015-11-01

    approach is to produce an assignment that does not optimize for all objective functions but is instead Pareto optimal ( Pareto 1906). Definition 2-20... Pareto optimal (also called Pareto efficient): An assignment is Pareto optimal relative to a set of objective functions O if it is impossible to change...to another objective function . The Pareto frontier is the set of assignments that are Pareto optimal. By seeking a solution that is Pareto optimal

  6. Entrepreneurs’ optimism, cognitive style and persistence

    OpenAIRE

    Adomako, Samuel; Danso, Albert; Uddin, Moshfique; Damoah, John Ofori

    2015-01-01

    Purpose – The purpose of this paper is to examine the moderating effects of cognitive style dimensions on the relationship between entrepreneurs’ optimism and persistence. Design/methodology/approach – This theoretically derived research model is empirically validated using survey data from 198 small and medium-sized enterprises in Ghana. Findings – The study’s empirical findings are that the relationship between entrepreneurs’ optimism and entrepreneurial persistence is enha...

  7. Optimal Wentzell Boundary Control of Parabolic Equations

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Yousong, E-mail: yousong.luo@rmit.edu.au [RMIT University, School of Mathematical and Geospatial Sciences (Australia)

    2017-04-15

    This paper deals with a class of optimal control problems governed by an initial-boundary value problem of a parabolic equation. The case of semi-linear boundary control is studied where the control is applied to the system via the Wentzell boundary condition. The differentiability of the state variable with respect to the control is established and hence a necessary condition is derived for the optimal solution in the case of both unconstrained and constrained problems. The condition is also sufficient for the unconstrained convex problems. A second order condition is also derived.

  8. Bicyclo[2.2.1]hept-2-en-7-yl 4-bromobenzoate

    Directory of Open Access Journals (Sweden)

    Barry A. Lloyd

    2012-07-01

    Full Text Available The structure of the title compound, C14H13BrO2, which contains a norbornenyl group and a 4-bromobenzoate ester at the single C-atom bridge, has been redetermined [see McDonald & Trotter (1965. Acta Cryst. 19, 456–463] to modern standards to establish high-precision geometrical data to compare with norbornyl and other tetracyclic 4-bromobenzoates. Possible structural evidence is sought to help explain solvolytic reactivities.

  9. Dynamical System Approaches to Combinatorial Optimization

    DEFF Research Database (Denmark)

    Starke, Jens

    2013-01-01

    of large times as an asymptotically stable point of the dynamics. The obtained solutions are often not globally optimal but good approximations of it. Dynamical system and neural network approaches are appropriate methods for distributed and parallel processing. Because of the parallelization......Several dynamical system approaches to combinatorial optimization problems are described and compared. These include dynamical systems derived from penalty methods; the approach of Hopfield and Tank; self-organizing maps, that is, Kohonen networks; coupled selection equations; and hybrid methods...... thereof can be used as models for many industrial problems like manufacturing planning and optimization of flexible manufacturing systems. This is illustrated for an example in distributed robotic systems....

  10. Intrarectal artemisinin derivatives

    NARCIS (Netherlands)

    Nosten, F.; van Vugt, M.; White, N. J.

    1998-01-01

    The artemisinin derivatives are the most potent antimalarials. They are rapidly absorbed orally, parenterally and intra-rectally. The latter mode of administration is particularly interesting in rural tropics. Preliminary studies have shown that artemisinin and its derivatives artesunate and

  11. Applications of combinatorial optimization

    CERN Document Server

    Paschos, Vangelis Th

    2013-01-01

    Combinatorial optimization is a multidisciplinary scientific area, lying in the interface of three major scientific domains: mathematics, theoretical computer science and management. The three volumes of the Combinatorial Optimization series aims to cover a wide range of topics in this area. These topics also deal with fundamental notions and approaches as with several classical applications of combinatorial optimization. "Applications of Combinatorial Optimization" is presenting a certain number among the most common and well-known applications of Combinatorial Optimization.

  12. The Ungraded Derived Category

    OpenAIRE

    Stai, Torkil Utvik

    2012-01-01

    By means of the ungraded derived category we prove that the orbit category of the bounded derived category of an iterated tilted algebra with respect to translation is triangulated in such a way that the canonical functor from the bounded derived category to the orbit category becomes a triangle functor.

  13. Theory of optimal beam splitting by phase gratings. I. One-dimensional gratings.

    Science.gov (United States)

    Romero, Louis A; Dickey, Fred M

    2007-08-01

    We give an analytical basis for the theory of optimal beam splitting by one-dimensional gratings. In particular, we use methods from the calculus of variations to derive analytical expressions for the optimal phase function.

  14. Shape Optimization of Swimming Sheets

    Energy Technology Data Exchange (ETDEWEB)

    Wilkening, J.; Hosoi, A.E.

    2005-03-01

    The swimming behavior of a flexible sheet which moves by propagating deformation waves along its body was first studied by G. I. Taylor in 1951. In addition to being of theoretical interest, this problem serves as a useful model of the locomotion of gastropods and various micro-organisms. Although the mechanics of swimming via wave propagation has been studied extensively, relatively little work has been done to define or describe optimal swimming by this mechanism.We carry out this objective for a sheet that is separated from a rigid substrate by a thin film of viscous Newtonian fluid. Using a lubrication approximation to model the dynamics, we derive the relevant Euler-Lagrange equations to optimize swimming speed and efficiency. The optimization equations are solved numerically using two different schemes: a limited memory BFGS method that uses cubic splines to represent the wave profile, and a multi-shooting Runge-Kutta approach that uses the Levenberg-Marquardt method to vary the parameters of the equations until the constraints are satisfied. The former approach is less efficient but generalizes nicely to the non-lubrication setting. For each optimization problem we obtain a one parameter family of solutions that becomes singular in a self-similar fashion as the parameter approaches a critical value. We explore the validity of the lubrication approximation near this singular limit by monitoring higher order corrections to the zeroth order theory and by comparing the results with finite element solutions of the full Stokes equations.

  15. Multilevel algorithms for nonlinear optimization

    Science.gov (United States)

    Alexandrov, Natalia; Dennis, J. E., Jr.

    1994-01-01

    Multidisciplinary design optimization (MDO) gives rise to nonlinear optimization problems characterized by a large number of constraints that naturally occur in blocks. We propose a class of multilevel optimization methods motivated by the structure and number of constraints and by the expense of the derivative computations for MDO. The algorithms are an extension to the nonlinear programming problem of the successful class of local Brown-Brent algorithms for nonlinear equations. Our extensions allow the user to partition constraints into arbitrary blocks to fit the application, and they separately process each block and the objective function, restricted to certain subspaces. The methods use trust regions as a globalization strategy, and they have been shown to be globally convergent under reasonable assumptions. The multilevel algorithms can be applied to all classes of MDO formulations. Multilevel algorithms for solving nonlinear systems of equations are a special case of the multilevel optimization methods. In this case, they can be viewed as a trust-region globalization of the Brown-Brent class.

  16. Optimal poroelastic layer sequencing for sound transmission loss maximization by topology optimization method.

    Science.gov (United States)

    Lee, Joong Seok; Kim, Eun Il; Kim, Yoon Young; Kim, Jung Soo; Kang, Yeon June

    2007-10-01

    Optimal layer sequencing of a multilayered acoustical foam is solved to maximize its sound transmission loss. A foam consisting of air and poroelastic layers can be optimized when a limited amount of a poroelastic material is allowed. By formulating the sound transmission loss maximization problem as a one-dimensional topology optimization problem, optimal layer sequencing and thickness were systematically found for several single and ranges of frequencies. For optimization, the transmission losses of air and poroelastic layers were calculated by the transfer matrix derived from Biot's theory. By interpolating five intrinsic parameters among several poroelastic material parameters, distinct air-poroelastic layer distributions were obtained; no filtering or postprocessing was necessary. The optimized foam layouts by the proposed method were shown to differ depending on the frequency bands of interest.

  17. Optimal Time Windows of Integration

    Directory of Open Access Journals (Sweden)

    Hans Colonius

    2011-10-01

    Full Text Available The spatiotemporal window of integration has become a widely accepted concept in multisensory research: crossmodal information falling within this window is highly likely to be integrated, whereas information falling outside is not. Making explicit assumptions about the arrival time difference between peripheral sensory processing times triggered by a crossmodal stimulus set, we derive a decision rule that determines an optimal window width as a function of (i the prior odds in favor of a common multisensory source, (ii the likelihood of arrival time differences, and (iii the payoff for making correct or wrong decisions. Empirical support for this approach will be presented.

  18. Optimal purely functional priority queues

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Okasaki, Chris

    1996-01-01

    Brodal recently introduced the first implementation of imperative priority queues to support findMin, insert and meld in O(1) worst-case time, and deleteMin in O(log n) worst-case time. These bounds are asymptotically optimal among all comparison-based priority queues. In this paper, we adapt...... Brodal's data structure to a purely functional setting. In doing so, we both simplify the data structure and clarify its relationship to the binomial queues of Vuillemin, which support all four operations in O(log n) time. Specifically, we derive our implementation from binomial queues in three steps...

  19. Global Optimization using Interval Analysis : Interval Optimization for Aerospace Applications

    NARCIS (Netherlands)

    Van Kampen, E.

    2010-01-01

    Optimization is an important element in aerospace related research. It is encountered for example in trajectory optimization problems, such as: satellite formation flying, spacecraft re-entry optimization and airport approach and departure optimization; in control optimization, for example in

  20. Physical parameter optimization by Response Surface Methodology ...

    African Journals Online (AJOL)

    Response Surface Methodology (RSM) is an empirical technique involving the use of Design Expert software to derive a predictive model similar to regression analysis. This present study explains the significant application of RSM in optimization of lipase production by Aspergillus niger. The experimental validation of the ...

  1. Optimization of parameters for Agrobacterium mediated ...

    African Journals Online (AJOL)

    satyam

    2013-03-13

    Mar 13, 2013 ... Agrobacterium mediated transformation of black gram using cotyledon derived calli was optimized based on. GUS histochemical assay. Subculturing of the explants prior to infection caused mechanical injury facilitating bacterial penetration into the tissue as well as production of vir gene inducers and ...

  2. Statistical experimental methods for optimizing the cultivating ...

    African Journals Online (AJOL)

    Central composite experimental design and response surface analysis were adopted to derive a statistical model for optimizing the culture conditions. From the obtained results, it can be concluded that the optimum parameters were: temperature, 15.3°C; pH, 5.56; inoculum size, 4%; liquid volume, 70 ml in 250 ml flask; ...

  3. Benchmarking optimization solvers for structural topology optimization

    DEFF Research Database (Denmark)

    Rojas Labanda, Susana; Stolpe, Mathias

    2015-01-01

    sizes is developed for this benchmarking. The problems are based on a material interpolation scheme combined with a density filter. Different optimization solvers including Optimality Criteria (OC), the Method of Moving Asymptotes (MMA) and its globally convergent version GCMMA, the interior point...

  4. Optimized State Model of Piecewise-Linear Dynamical Systems

    Directory of Open Access Journals (Sweden)

    J. Brzobohaty

    2003-04-01

    Full Text Available The conditions for an optimized design of the second dynamicalsystem having low eigenvalue sensitivities are directly derived. Theirmore general form is in accordance with the previous results obtainedby using linear topological conjugacy.

  5. Taxation of Derivatives

    DEFF Research Database (Denmark)

    Dyppel, Katja Joo

    2013-01-01

    The main objective for this thesis is to analyse and systematise the Danish legislation on taxation of derivatives. According to financial terminology, a derivative is a financial instrument. Its value is derived from changes in the value of one or more underlying assets.The most common derivatives...... with the scope of sections 29-33 of the Danish Act on Taxation of Gains and Losses on Claims and Debt and the tax consequences for the covered financial contracts. In the analysis of taxation of derivatives, the fundamental issues of qualification and tax treatment of the instruments are dealt with....... are known as futures, forwards, options and swaps. Derivatives are traded for the purpose of hedging financial or business risk, speculating in future spot prices and taking advantage of arbitrage opportunities. This market has increased tremendously in recent years. The term derivative is not used...

  6. Mechanical Design Optimization Using Advanced Optimization Techniques

    CERN Document Server

    Rao, R Venkata

    2012-01-01

    Mechanical design includes an optimization process in which designers always consider objectives such as strength, deflection, weight, wear, corrosion, etc. depending on the requirements. However, design optimization for a complete mechanical assembly leads to a complicated objective function with a large number of design variables. It is a good practice to apply optimization techniques for individual components or intermediate assemblies than a complete assembly. Analytical or numerical methods for calculating the extreme values of a function may perform well in many practical cases, but may fail in more complex design situations. In real design problems, the number of design parameters can be very large and their influence on the value to be optimized (the goal function) can be very complicated, having nonlinear character. In these complex cases, advanced optimization algorithms offer solutions to the problems, because they find a solution near to the global optimum within reasonable time and computational ...

  7. Oil Reservoir Production Optimization using Optimal Control

    DEFF Research Database (Denmark)

    Völcker, Carsten; Jørgensen, John Bagterp; Stenby, Erling Halfdan

    2011-01-01

    Practical oil reservoir management involves solution of large-scale constrained optimal control problems. In this paper we present a numerical method for solution of large-scale constrained optimal control problems. The method is a single-shooting method that computes the gradients using the adjo...... reservoir using water ooding and smart well technology. Compared to the uncontrolled case, the optimal operation increases the Net Present Value of the oil field by 10%.......Practical oil reservoir management involves solution of large-scale constrained optimal control problems. In this paper we present a numerical method for solution of large-scale constrained optimal control problems. The method is a single-shooting method that computes the gradients using...

  8. Derivative-based optimization in colour image filtering an application for derivative learning

    Directory of Open Access Journals (Sweden)

    A. Sapena

    2009-06-01

    Full Text Available La noción de derivada de una función y su aplicación a la optimización de funciones es un problema interesante e ilustrativo para los estudiantes de ingeniería. En este trabajo, desarrollamos un aplicación del concepto de derivada para la optimización del filtrado de imágenes en color. Ello implica ajustar el parámetro del filtro para obtener un rendimiento óptimo de filtrado. Proponemos maximizar la calidad de la imagen filtrada representada por la relación señal-ruido (Peak Signal-to-Noise Ratio, PSNR, que es una función del parámetro del filtro. El valor óptimo del parámetro se obtiene mediante un algoritmo basado en la aproximación de la derivada de la función del PSNR de manera que se obtenga la imagen filtrada óptima.

  9. Robust mutant strain design by pessimistic optimization.

    Science.gov (United States)

    Apaydin, Meltem; Xu, Liang; Zeng, Bo; Qian, Xiaoning

    2017-10-03

    Flux Balance Analysis (FBA) based mathematical modeling enables in silico prediction of systems behavior for genome-scale metabolic networks. Computational methods have been derived in the FBA framework to solve bi-level optimization for deriving "optimal" mutant microbial strains with targeted biochemical overproduction. The common inherent assumption of these methods is that the surviving mutants will always cooperate with the engineering objective by overproducing the maximum desired biochemicals. However, it has been shown that this optimistic assumption may not be valid in practice. We study the validity and robustness of existing bi-level methods for strain optimization under uncertainty and non-cooperative environment. More importantly, we propose new pessimistic optimization formulations: P-ROOM and P-OptKnock, aiming to derive robust mutants with the desired overproduction under two different mutant cell survival models: (1) ROOM assuming mutants have the minimum changes in reaction fluxes from wild-type flux values, and (2) the one considered by OptKnock maximizing the biomass production yield. When optimizing for desired overproduction, our pessimistic formulations derive more robust mutant strains by considering the uncertainty of the cell survival models at the inner level and the cooperation between the outer- and inner-level decision makers. For both P-ROOM and P-OptKnock, by converting multi-level formulations into single-level Mixed Integer Programming (MIP) problems based on the strong duality theorem, we can derive exact optimal solutions that are highly scalable with large networks. Our robust formulations P-ROOM and P-OptKnock are tested with a small E. coli core metabolic network and a large-scale E. coli iAF1260 network. We demonstrate that the original bi-level formulations (ROOM and OptKnock) derive mutants that may not achieve the predicted overproduction under uncertainty and non-cooperative environment. The knockouts obtained by the

  10. Particle Swarm Optimization Toolbox

    Science.gov (United States)

    Grant, Michael J.

    2010-01-01

    The Particle Swarm Optimization Toolbox is a library of evolutionary optimization tools developed in the MATLAB environment. The algorithms contained in the library include a genetic algorithm (GA), a single-objective particle swarm optimizer (SOPSO), and a multi-objective particle swarm optimizer (MOPSO). Development focused on both the SOPSO and MOPSO. A GA was included mainly for comparison purposes, and the particle swarm optimizers appeared to perform better for a wide variety of optimization problems. All algorithms are capable of performing unconstrained and constrained optimization. The particle swarm optimizers are capable of performing single and multi-objective optimization. The SOPSO and MOPSO algorithms are based on swarming theory and bird-flocking patterns to search the trade space for the optimal solution or optimal trade in competing objectives. The MOPSO generates Pareto fronts for objectives that are in competition. A GA, based on Darwin evolutionary theory, is also included in the library. The GA consists of individuals that form a population in the design space. The population mates to form offspring at new locations in the design space. These offspring contain traits from both of the parents. The algorithm is based on this combination of traits from parents to hopefully provide an improved solution than either of the original parents. As the algorithm progresses, individuals that hold these optimal traits will emerge as the optimal solutions. Due to the generic design of all optimization algorithms, each algorithm interfaces with a user-supplied objective function. This function serves as a "black-box" to the optimizers in which the only purpose of this function is to evaluate solutions provided by the optimizers. Hence, the user-supplied function can be numerical simulations, analytical functions, etc., since the specific detail of this function is of no concern to the optimizer. These algorithms were originally developed to support entry

  11. On a linear-quadratic problem with Caputo derivative

    Directory of Open Access Journals (Sweden)

    Dariusz Idczak

    2016-01-01

    Full Text Available In this paper, we study a linear-quadratic optimal control problem with a fractional control system containing a Caputo derivative of unknown function. First, we derive the formulas for the differential and gradient of the cost functional under given constraints. Next, we prove an existence result and derive a maximum principle. Finally, we describe the gradient and projection of the gradient methods for the problem under consideration.

  12. Generalized Differential Calculus and Applications to Optimization

    Science.gov (United States)

    Rector, Robert Blake Hayden

    This thesis contains contributions in three areas: the theory of generalized calculus, numerical algorithms for operations research, and applications of optimization to problems in modern electric power systems. A geometric approach is used to advance the theory and tools used for studying generalized notions of derivatives for nonsmooth functions. These advances specifically pertain to methods for calculating subdifferentials and to expanding our understanding of a certain notion of derivative of set-valued maps, called the coderivative, in infinite dimensions. A strong understanding of the subdifferential is essential for numerical optimization algorithms, which are developed and applied to nonsmooth problems in operations research, including non-convex problems. Finally, an optimization framework is applied to solve a problem in electric power systems involving a smart solar inverter and battery storage system providing energy and ancillary services to the grid.

  13. Aeroelastic optimization of a helicopter rotor

    Science.gov (United States)

    Lim, Joon W.; Chopra, Inderjit

    1988-01-01

    Structural optimization of a hingeless rotor is investigated to reduce oscillatory hub loads while maintaining aeroelastic stability in forward flight. Design variables include spanwise distribution of nonstructural mass, chordwise location of blade center of gravity and blade bending stiffnesses (flap, lag and torsion). A comprehensive aeroelastic analysis of rotors, based on a finite element method in space and time, is linked with optimization algorithms to perform optimization of rotor blades. Sensitivity derivatives of blade response, hub loads, and eigenvalues with respect to the design variables are derived using a direct analytical approach, and constitute an integral part of the basic blade response and stability analyses. This approach reduces the computation time substantially; an 80 percent reduction of CPU time to achieve an optimum solution, as compared to the widely adopted finite difference approach. Through stiffness and nonstructural mass distributions, a 60-90 percent reduction in all six 4/rev hub loads is achieved for a four-bladed soft-inplane rotor.

  14. Improved Propulsion Modeling for Low-Thrust Trajectory Optimization

    Science.gov (United States)

    Knittel, Jeremy M.; Englander, Jacob A.; Ozimek, Martin T.; Atchison, Justin A.; Gould, Julian J.

    2017-01-01

    Low-thrust trajectory design is tightly coupled with spacecraft systems design. In particular, the propulsion and power characteristics of a low-thrust spacecraft are major drivers in the design of the optimal trajectory. Accurate modeling of the power and propulsion behavior is essential for meaningful low-thrust trajectory optimization. In this work, we discuss new techniques to improve the accuracy of propulsion modeling in low-thrust trajectory optimization while maintaining the smooth derivatives that are necessary for a gradient-based optimizer. The resulting model is significantly more realistic than the industry standard and performs well inside an optimizer. A variety of deep-space trajectory examples are presented.

  15. Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives.

    Science.gov (United States)

    Knecht, W; Löffler, M

    1998-11-01

    The isoxazol leflunomide (N-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide) and its active metabolite A77-1726 (N-(4-trifluoromethyl)-phenyl-2-cyano-3-hydroxy-crotonic acidamide) are promising disease-modifying antirheumatic drugs now in clinical trials. The malononitrilamides MNA279 (2-cyano-3-cyclopropyl-3-oxo-(4-cyanophenyl)propionamide) MNA715(N-(4-trifluoromethyl)-phenyl-2-cyano-3-hydroxy-hept-2-en-6- in-carboxylic acidamide) and HR325 (1(3-methyl-4-trifluoro methylphenyl-carbamoyl)-2-cyclopropyl-2oxo-propionitrile) were shown to block rejection after allograft and xenograft transplantation in animals. Brequinar and other cinchoninic acid derivatives have also been evaluated as immuno-suppressive agents. A77-1726, HR325 and brequinar have been shown to have strong inhibitory effects on mitochondrial dihydroorotate dehydrogenase [EC 1.3.99.11], the fourth enzyme of pyrimidine de novo synthesis, with concomitant reduction of pyrimidine nucleotide pools. Pyrimidine nucleotides are essential for normal immune cell functions. Because most investigations had been carried out with cells, cell homogenates or mitochondrial fractions, it was the rationale of the present study to differentiate, under standardized conditions, the effect of leflunomide, A77-1726, MNA279, MNA715, HR 325 and brequinar on the recombinant rat and human enzymes, which were purified in our laboratory. Whereas leflunomide was a relatively weak inhibitor of the rat (IC50 = 6.3 microM) and human (IC50 = 98 microM) dihydroorotate dehydrogenase, the influence of A77-1726, MNA 279, MNA715 and HR325 was of comparable efficacy for either the rat (range of IC50, 19-53 nM) or the human enzyme (range of IC50, 0.5-2.3 microM). From the IC50 values, it was deduced that brequinar was a more potent inhibitor of the human dihydroorotate dehydrogenase activity (IC50 = 10 nM) than of the rat enzyme (IC50 = 367 nM). The rat enzyme was influenced by all isoxazol derivatives to a greater extent (IC50 = 19

  16. Multidisciplinary Optimization for Aerospace Using Genetic Optimization

    Science.gov (United States)

    Pak, Chan-gi; Hahn, Edward E.; Herrera, Claudia Y.

    2007-01-01

    In support of the ARMD guidelines NASA's Dryden Flight Research Center is developing a multidisciplinary design and optimization tool This tool will leverage existing tools and practices, and allow the easy integration and adoption of new state-of-the-art software. Optimization has made its way into many mainstream applications. For example NASTRAN(TradeMark) has its solution sequence 200 for Design Optimization, and MATLAB(TradeMark) has an Optimization Tool box. Other packages, such as ZAERO(TradeMark) aeroelastic panel code and the CFL3D(TradeMark) Navier-Stokes solver have no built in optimizer. The goal of the tool development is to generate a central executive capable of using disparate software packages ina cross platform network environment so as to quickly perform optimization and design tasks in a cohesive streamlined manner. A provided figure (Figure 1) shows a typical set of tools and their relation to the central executive. Optimization can take place within each individual too, or in a loop between the executive and the tool, or both.

  17. Multiple Satellite Trajectory Optimization

    National Research Council Canada - National Science Library

    Mendy Jr, Paul B

    2004-01-01

    This thesis develops and validates a satellite trajectory optimization model. A summary is given of the general mathematical principles of dynamic optimal control to minimize fuel consumed or transfer time...

  18. Optimal Alarm Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — An optimal alarm system is simply an optimal level-crossing predictor that can be designed to elicit the fewest false alarms for a fixed detection probability. It...

  19. Higher derivative mimetic gravity

    Science.gov (United States)

    Gorji, Mohammad Ali; Mansoori, Seyed Ali Hosseini; Firouzjahi, Hassan

    2018-01-01

    We study cosmological perturbations in mimetic gravity in the presence of classified higher derivative terms which can make the mimetic perturbations stable. We show that the quadratic higher derivative terms which are independent of curvature and the cubic higher derivative terms which come from curvature corrections are sufficient to remove instabilities in mimetic perturbations. The classified higher derivative terms have the same dimensions but they contribute differently in the background and perturbed equations. Therefore, we can control both the background and the perturbation equations allowing us to construct the higher derivative extension of mimetic dark matter and the mimetic nonsingular bouncing scenarios. The latter can be thought as a new higher derivative effective action for the loop quantum cosmology scenario in which the equations of motion coincide with those suggested by loop quantum cosmology. We investigate a possible connection between the mimetic cosmology and the Randall-Sundrum cosmology.

  20. Educational Tool for Optimal Controller Tuning Using Evolutionary Strategies

    Science.gov (United States)

    Carmona Morales, D.; Jimenez-Hornero, J. E.; Vazquez, F.; Morilla, F.

    2012-01-01

    In this paper, an optimal tuning tool is presented for control structures based on multivariable proportional-integral-derivative (PID) control, using genetic algorithms as an alternative to traditional optimization algorithms. From an educational point of view, this tool provides students with the necessary means to consolidate their knowledge on…

  1. Optimal fractional order PID design via Tabu Search based algorithm.

    Science.gov (United States)

    Ateş, Abdullah; Yeroglu, Celaleddin

    2016-01-01

    This paper presents an optimization method based on the Tabu Search Algorithm (TSA) to design a Fractional-Order Proportional-Integral-Derivative (FOPID) controller. All parameter computations of the FOPID employ random initial conditions, using the proposed optimization method. Illustrative examples demonstrate the performance of the proposed FOPID controller design method. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  2. Comments on `A discrete optimal control problem for descriptor systems'

    DEFF Research Database (Denmark)

    Ravn, Hans

    1990-01-01

    In the above-mentioned work (see ibid., vol.34, p.177-81 (1989)), necessary and sufficient optimality conditions are derived for a discrete-time optimal problem, as well as other specific cases of implicit and explicit dynamic systems. The commenter corrects a mistake and demonstrates...

  3. Portfolio Optimization with Stochastic Dividends and Stochastic Volatility

    Science.gov (United States)

    Varga, Katherine Yvonne

    2015-01-01

    We consider an optimal investment-consumption portfolio optimization model in which an investor receives stochastic dividends. As a first problem, we allow the drift of stock price to be a bounded function. Next, we consider a stochastic volatility model. In each problem, we use the dynamic programming method to derive the Hamilton-Jacobi-Bellman…

  4. Auditory-like filterbank: An optimal speech processor for efficient ...

    Indian Academy of Sciences (India)

    The transmitter and the receiver in a communication system have to be designed optimally with respect to one another to ensure reliable and efficient communication. Following this principle, we derive an optimal filterbank for processing speech signal in the listener's auditory system (receiver), so that maximum information ...

  5. An optimal speech processor for efficient human speech ...

    Indian Academy of Sciences (India)

    Abstract. The transmitter and the receiver in a communication system have to be designed optimally with respect to one another to ensure reliable and efficient com- munication. Following this principle, we derive an optimal filterbank for processing speech signal in the listener's auditory system (receiver), so that maximum ...

  6. An Optimal Stochastic Investment and Consumption Strategy with ...

    African Journals Online (AJOL)

    The goal is to choose optimal investment and consumption policies that maximize the finite horizon expected discounted logarithmic utility of consumption and terminal wealth. A dynamical programming principle is used to derive the optimal investment and consumption strategy when the state variable follows a ...

  7. Derivative actions in China

    OpenAIRE

    Lin, Shaowei

    2014-01-01

    The enactment of derivative action was expected to be actively used by shareholders to protect their interests. In fact, it turned out that this reform effort seemed futile as the right to engage in such actions was rarely exercised. This raises a question about the role of derivative actions in China; namely, should a derivative action system play a key role in protecting shareholder interests? If the answer is positive, the next question is how such a system could be improved...

  8. Global Derivatives Market

    Directory of Open Access Journals (Sweden)

    Stankovska Aleksandra

    2017-06-01

    Full Text Available Globalization of financial markets led to the enormous growth of volume and diversification of financial transactions. Financial derivatives were the basic elements of this growth. Derivatives play a useful and important role in hedging and risk management, but they also pose several dangers to the stability of financial markets and thereby the overall economy. Derivatives are used to hedge and speculate the risk associated with commerce and finance.

  9. Optimization algorithms and applications

    CERN Document Server

    Arora, Rajesh Kumar

    2015-01-01

    Choose the Correct Solution Method for Your Optimization ProblemOptimization: Algorithms and Applications presents a variety of solution techniques for optimization problems, emphasizing concepts rather than rigorous mathematical details and proofs. The book covers both gradient and stochastic methods as solution techniques for unconstrained and constrained optimization problems. It discusses the conjugate gradient method, Broyden-Fletcher-Goldfarb-Shanno algorithm, Powell method, penalty function, augmented Lagrange multiplier method, sequential quadratic programming, method of feasible direc

  10. Adaptive Bacterial Foraging Optimization

    OpenAIRE

    Hanning Chen; Yunlong Zhu; Kunyuan Hu

    2011-01-01

    Bacterial Foraging Optimization (BFO) is a recently developed nature-inspired optimization algorithm, which is based on the foraging behavior of E. coli bacteria. Up to now, BFO has been applied successfully to some engineering problems due to its simplicity and ease of implementation. However, BFO possesses a poor convergence behavior over complex optimization problems as compared to other nature-inspired optimization techniques. This paper first analyzes how ...

  11. Pseudolinear functions and optimization

    CERN Document Server

    Mishra, Shashi Kant

    2015-01-01

    Pseudolinear Functions and Optimization is the first book to focus exclusively on pseudolinear functions, a class of generalized convex functions. It discusses the properties, characterizations, and applications of pseudolinear functions in nonlinear optimization problems.The book describes the characterizations of solution sets of various optimization problems. It examines multiobjective pseudolinear, multiobjective fractional pseudolinear, static minmax pseudolinear, and static minmax fractional pseudolinear optimization problems and their results. The authors extend these results to locally

  12. Optimization techniques in statistics

    CERN Document Server

    Rustagi, Jagdish S

    1994-01-01

    Statistics help guide us to optimal decisions under uncertainty. A large variety of statistical problems are essentially solutions to optimization problems. The mathematical techniques of optimization are fundamentalto statistical theory and practice. In this book, Jagdish Rustagi provides full-spectrum coverage of these methods, ranging from classical optimization and Lagrange multipliers, to numerical techniques using gradients or direct search, to linear, nonlinear, and dynamic programming using the Kuhn-Tucker conditions or the Pontryagin maximal principle. Variational methods and optimiza

  13. Endohedral Metallofullerene Derivatives

    Science.gov (United States)

    Dorn, Harry C. (Inventor); Iezzi, Erick B. (Inventor); Duchamp, James (Inventor)

    2008-01-01

    Trimetallic nitride endohedral metallofullerene derivatives and their preparation are described. The trimetallic nitride endohedral metallofullerene derivatives have the general formula A(sub 3-n)X(sub n)@C(sub m)(R) where n ranges from 0 to 3, A and X may be trivalent metals and may be either rare earth metal or group IIIB metals, m is between about 60 and about 200, and R is preferably an organic group. Derivatives where the R group forms cyclized derivatives with the fullerene cage are also described.

  14. Cyclus Optimization Strategies

    OpenAIRE

    Carlsen, Robert

    2015-01-01

    Some preliminary deployment optimization techniques and analysis for nuclear fuel cycle transition scenarios.  Also discusses high throughput computing (highly parallel) optimization with Cyclus.  Finishes with brief discussion of risk mitigation optimization for disruption scenarios.  Presented as part of the 2014 Cyclus Review Meeting, October 23, 2014, Argonne National Laboratory.

  15. Symmetries in Optimal Control

    NARCIS (Netherlands)

    Schaft, A.J. van der

    1987-01-01

    It is argued that the existence of symmetries may simplify, as in classical mechanics, the solution of optimal control problems. A procedure for obtaining symmetries for the optimal Hamiltonian resulting from the Maximum Principle is given; this avoids the actual calculation of the optimal

  16. Optimal Control with Time Delays via the Penalty Method

    Directory of Open Access Journals (Sweden)

    Mohammed Benharrat

    2014-01-01

    Full Text Available We prove necessary optimality conditions of Euler-Lagrange type for a problem of the calculus of variations with time delays, where the delay in the unknown function is different from the delay in its derivative. Then, a more general optimal control problem with time delays is considered. Main result gives a convergence theorem, allowing us to obtain a solution to the delayed optimal control problem by considering a sequence of delayed problems of the calculus of variations.

  17. Lower Bounds for Higher-Order Convex Optimization

    OpenAIRE

    Agarwal, Naman; Hazan, Elad

    2017-01-01

    State-of-the-art methods in convex and non-convex optimization employ higher-order derivative information, either implicitly or explicitly. We explore the limitations of higher-order optimization and prove that even for convex optimization, a polynomial dependence on the approximation guarantee and higher-order smoothness parameters is necessary. As a special case, we show Nesterov's accelerated cubic regularization method to be nearly tight.

  18. Probabilistic Cloning of Three Real States with Optimal Success Probabilities

    Science.gov (United States)

    Rui, Pin-shu

    2017-06-01

    We investigate the probabilistic quantum cloning (PQC) of three real states with average probability distribution. To get the analytic forms of the optimal success probabilities we assume that the three states have only two pairwise inner products. Based on the optimal success probabilities, we derive the explicit form of 1 →2 PQC for cloning three real states. The unitary operation needed in the PQC process is worked out too. The optimal success probabilities are also generalized to the M→ N PQC case.

  19. Optimal control of electrostatic self-assembly of binary monolayers

    Energy Technology Data Exchange (ETDEWEB)

    Shestopalov, N V; Henkelman, G; Powell, C T; Rodin, G J [Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, TX 78712 (United States)], E-mail: nikolay@ices.utexas.edu

    2009-05-15

    A simple macroscopic model is used to determine an optimal annealing schedule for self-assembly of binary monolayers of spherical particles. The model assumes that a single rate-controlling mechanism is responsible for the formation of spatially ordered structures and that its rate follows an Arrhenius form. The optimal schedule is derived in an analytical form using classical optimization methods. Molecular dynamics simulations of the self-assembly demonstrate that the proposed schedule outperforms other schedules commonly used for simulated annealing.

  20. Optimization and optimal control in automotive systems

    CERN Document Server

    Kolmanovsky, Ilya; Steinbuch, Maarten; Re, Luigi

    2014-01-01

    This book demonstrates the use of the optimization techniques that are becoming essential to meet the increasing stringency and variety of requirements for automotive systems. It shows the reader how to move away from earlier  approaches, based on some degree of heuristics, to the use of  more and more common systematic methods. Even systematic methods can be developed and applied in a large number of forms so the text collects contributions from across the theory, methods and real-world automotive applications of optimization. Greater fuel economy, significant reductions in permissible emissions, new drivability requirements and the generally increasing complexity of automotive systems are among the criteria that the contributing authors set themselves to meet. In many cases multiple and often conflicting requirements give rise to multi-objective constrained optimization problems which are also considered. Some of these problems fall into the domain of the traditional multi-disciplinary optimization applie...

  1. Post Pareto optimization-A case

    Science.gov (United States)

    Popov, Stoyan; Baeva, Silvia; Marinova, Daniela

    2017-12-01

    Simulation performance may be evaluated according to multiple quality measures that are in competition and their simultaneous consideration poses a conflict. In the current study we propose a practical framework for investigating such simulation performance criteria, exploring the inherent conflicts amongst them and identifying the best available tradeoffs, based upon multi-objective Pareto optimization. This approach necessitates the rigorous derivation of performance criteria to serve as objective functions and undergo vector optimization. We demonstrate the effectiveness of our proposed approach by applying it with multiple stochastic quality measures. We formulate performance criteria of this use-case, pose an optimization problem, and solve it by means of a simulation-based Pareto approach. Upon attainment of the underlying Pareto Frontier, we analyze it and prescribe preference-dependent configurations for the optimal simulation training.

  2. Multi-Criteria Optimization for Image Guidance

    CERN Document Server

    Winey, Brian

    2011-01-01

    Purpose: To develop a multi-criteria optimization framework for image guided radiotherapy. Methods: An algorithm is proposed for a multi-criteria framework for the purpose of patient setup verification decision processes. Optimal patient setup shifts and rotations are not always straightforward, particularly for deformable or moving targets of the spine, abdomen, thorax, breast, head and neck and limbs. The algorithm relies upon dosimetric constraints and objectives to aid in the patient setup such that the patient is setup to maximize tumor dose coverage and minimize dose to organs at risk while allowing for daily clinical changes. A simple 1D model and a lung lesion are presented. Results: The algorithm delivers a multi-criteria optimization framework allowing for clinical decisions to accommodate patient target variation make setup decisions less straightforward. With dosimetric considerations, optimal patient positions can be derived. Conclusions: A multi-criteria framework is demonstrated to aid in the p...

  3. Concepts of combinatorial optimization

    CERN Document Server

    Paschos, Vangelis Th

    2014-01-01

    Combinatorial optimization is a multidisciplinary scientific area, lying in the interface of three major scientific domains: mathematics, theoretical computer science and management.  The three volumes of the Combinatorial Optimization series aim to cover a wide range  of topics in this area. These topics also deal with fundamental notions and approaches as with several classical applications of combinatorial optimization.Concepts of Combinatorial Optimization, is divided into three parts:- On the complexity of combinatorial optimization problems, presenting basics about worst-case and randomi

  4. Ant Colony Optimization Applied on Combinatorial Problem for Optimal Power Flow Solution

    Directory of Open Access Journals (Sweden)

    Boumediene ALLAOUA

    2009-07-01

    Full Text Available This paper presents an efficient and reliable evolutionary-based approach to solve the optimal power flow (OPF combinatorial problem. The proposed approach employs Ant Colony Optimization (ACO algorithm for optimal settings of OPF combinatorial problem control variables. Incorporation of ACO as a derivative-free optimization technique in solving OPF problem significantly relieves the assumptions imposed on the optimized objective functions. The proposed approach has been examined and tested on the standard IEEE 57-bus test System with different objectives that reflect fuel cost minimization, voltage profile improvement, and voltage stability enhancement. The proposed approach results have been compared to those that reported in the literature recently. The results are promising and show the effectiveness and robustness of the proposed approach.

  5. The Dangers of Derivatives.

    Science.gov (United States)

    Blumenstyk, Goldie

    1994-01-01

    Heavy investment in derivatives, whose value derives from the price movement of some underlying security, has meant heavy losses for some colleges and universities despite the fact that institutional investors are required to assure that they understand the risks of such investment. (MSE)

  6. Integrated controls design optimization

    Science.gov (United States)

    Lou, Xinsheng; Neuschaefer, Carl H.

    2015-09-01

    A control system (207) for optimizing a chemical looping process of a power plant includes an optimizer (420), an income algorithm (230) and a cost algorithm (225) and a chemical looping process models. The process models are used to predict the process outputs from process input variables. Some of the process in puts and output variables are related to the income of the plant; and some others are related to the cost of the plant operations. The income algorithm (230) provides an income input to the optimizer (420) based on a plurality of input parameters (215) of the power plant. The cost algorithm (225) provides a cost input to the optimizer (420) based on a plurality of output parameters (220) of the power plant. The optimizer (420) determines an optimized operating parameter solution based on at least one of the income input and the cost input, and supplies the optimized operating parameter solution to the power plant.

  7. Evolutionary constrained optimization

    CERN Document Server

    Deb, Kalyanmoy

    2015-01-01

    This book makes available a self-contained collection of modern research addressing the general constrained optimization problems using evolutionary algorithms. Broadly the topics covered include constraint handling for single and multi-objective optimizations; penalty function based methodology; multi-objective based methodology; new constraint handling mechanism; hybrid methodology; scaling issues in constrained optimization; design of scalable test problems; parameter adaptation in constrained optimization; handling of integer, discrete and mix variables in addition to continuous variables; application of constraint handling techniques to real-world problems; and constrained optimization in dynamic environment. There is also a separate chapter on hybrid optimization, which is gaining lots of popularity nowadays due to its capability of bridging the gap between evolutionary and classical optimization. The material in the book is useful to researchers, novice, and experts alike. The book will also be useful...

  8. Particle Swarm Optimization

    Science.gov (United States)

    Venter, Gerhard; Sobieszczanski-Sobieski Jaroslaw

    2002-01-01

    The purpose of this paper is to show how the search algorithm known as particle swarm optimization performs. Here, particle swarm optimization is applied to structural design problems, but the method has a much wider range of possible applications. The paper's new contributions are improvements to the particle swarm optimization algorithm and conclusions and recommendations as to the utility of the algorithm, Results of numerical experiments for both continuous and discrete applications are presented in the paper. The results indicate that the particle swarm optimization algorithm does locate the constrained minimum design in continuous applications with very good precision, albeit at a much higher computational cost than that of a typical gradient based optimizer. However, the true potential of particle swarm optimization is primarily in applications with discrete and/or discontinuous functions and variables. Additionally, particle swarm optimization has the potential of efficient computation with very large numbers of concurrently operating processors.

  9. Interactive Topology Optimization

    DEFF Research Database (Denmark)

    Nobel-Jørgensen, Morten

    software where the users are assumed to be well-educated both in the finite element method and topology optimization. This dissertation describes how various topology optimization methods have been used for creating cross-platform applications with high performance. The user interface design is based......Interactivity is the continuous interaction between the user and the application to solve a task. Topology optimization is the optimization of structures in order to improve stiffness or other objectives. The goal of the thesis is to explore how topology optimization can be used in applications...... in an interactive and intuitive way. By creating such applications with an intuitive and simple user interface we allow non-engineers like designers and architects to easily experiment with boundary conditions, design domains and other optimization settings. This is in contrast to commercial topology optimization...

  10. Exploratory Factor Analysis: The Significance of Trust in a Revised Principal Academic Optimism Scale

    OpenAIRE

    Sartin, Marcus Clifton

    2016-01-01

    Principal Academic Optimism is an hypothesized latent construct that has strong theoretical foundations in both educational research and educational psychology. Academic Optimism derives from research on school academic optimism and teacher academic optimism, which originated via Hoys, Tarters, and Woolfolk Hoys (2006a; 2006b) merger of school climate research with research on learned optimism, stemming from Martin Seligmans (1998, 2006) research on positive psychology. Principal Academic...

  11. An Approach for the Reliability Based Design Optimization of Laminated Composite Plates

    OpenAIRE

    Lopez, Rafael Holdorf; Lemosse, Didier; Cursi, Eduardo Souza de; Rojas, Jhojan Enrique; El-Hami, Abdelkhalak

    2011-01-01

    Abstract This paper aims at optimizing laminated composite plates taking into account uncertainties in the structural dimensions. As laminated composites require a global optimization tool, the Particle Swarm (PSO) Optimization method was employed. A new reliability based design optimization (RBDO) methodology based on safety factors is presented and coupled with the PSO. Such safety factors are derived from the Karush-Kuhn-Tucker (KKT) optimality conditions of the reliability inde...

  12. Energy methods for hypersonic trajectory optimization

    Science.gov (United States)

    Chou, Han-Chang

    A family of near-optimal guidance laws for the ascent and descent trajectories between earth surface and earth orbit of fully reusable single-stage-to-orbit launch vehicles is derived. Of interest are both the optimal operation of the propulsion system and the optimal flight path. The method is based on selecting propulsion system modes and flight-path parameters that maximize a certain performance function. This function is derived from consideration of the energy-state model of the aircraft equations of motion. For ascent trajectories of vehicles employing hydrogen fuel, because the density of liquid hydrogen is relatively low, the sensitivity to perturbations in volume needs to be taken into consideration as well as weight sensitivity. The cost functional is then a weighted sum of fuel mass and volume; the weighting factor is chosen to minimize vehicle empty weight for a given payload mass and volume in orbit. Both airbreathing/rocket and all rocket propulsion systems are considered. For airbreathing/rocket vehicles, the optimal propulsion switching Mach numbers are determined and the use of liquid oxygen augmentation is investigated. For the vehicles with all rocket power, the desirability of tripropellant systems is investigated. In addition, time and heat load is minimized as well. For descent trajectories, the trade-off between minimizing heat load into the vehicle and maximizing cross range distance is investigated, as well as minimum time and minimum temperature paths. The results show that the optimization methodology can be used to derive a wide variety of near-optimal launch vehicle trajectories.

  13. Nanomaterials derived from metal-organic frameworks

    Science.gov (United States)

    Dang, Song; Zhu, Qi-Long; Xu, Qiang

    2018-01-01

    The thermal transformation of metal-organic frameworks (MOFs) generates a variety of nanostructured materials, including carbon-based materials, metal oxides, metal chalcogenides, metal phosphides and metal carbides. These derivatives of MOFs have characteristics such as high surface areas, permanent porosities and controllable functionalities that enable their good performance in sensing, gas storage, catalysis and energy-related applications. Although progress has been made to tune the morphologies of MOF-derived structures at the nanometre scale, it remains crucial to further our knowledge of the relationship between morphology and performance. In this Review, we summarize the synthetic strategies and optimized methods that enable control over the size, morphology, composition and structure of the derived nanomaterials. In addition, we compare the performance of materials prepared by the MOF-templated strategy and other synthetic methods. Our aim is to reveal the relationship between the morphology and the physico-chemical properties of MOF-derived nanostructures to optimize their performance for applications such as sensing, catalysis, and energy storage and conversion.

  14. Resolution enhancement in second-derivative spectra.

    Science.gov (United States)

    Czarnecki, Mirosław A

    2015-01-01

    Derivative spectroscopy is a powerful tool for the resolution enhancement in infrared, near-infrared, Raman, ultraviolet-visible, nuclear magnetic resonance, electron paramagnetic resonance, and fluorescence spectroscopy. Despite its great significance in analytical chemistry, not all aspects of the applications of this method have been explored as yet. This is the first systematic study of the parameters that influence the resolution enhancement in the second derivative spectra. The derivative spectra were calculated with the Savitzky-Golay method with different window size (5, 15, 25) and polynomial order (2, 4). The results obtained in this work show that the resolution enhancement in the second derivative spectra strongly depends on the data spacing in the original spectra, window size, polynomial order, and peak profile. As shown, the resolution enhancement is related to variations in the width of the peaks upon the differentiation. The present study reveals that in order to maximize the separation of the peaks in the second derivative spectra, the original spectra should be recorded at high resolution and differentiated using a small window size and high polynomial order. However, working with the real spectra one has to compromise between the noise reduction and optimization of the resolution enhancement in the second derivative spectra.

  15. Performance optimization of queueing systems with perturbation realization

    KAUST Repository

    Xia, Li

    2012-04-01

    After the intensive studies of queueing theory in the past decades, many excellent results in performance analysis have been obtained, and successful examples abound. However, exploring special features of queueing systems directly in performance optimization still seems to be a territory not very well cultivated. Recent progresses of perturbation analysis (PA) and sensitivity-based optimization provide a new perspective of performance optimization of queueing systems. PA utilizes the structural information of queueing systems to efficiently extract the performance sensitivity information from a sample path of system. This paper gives a brief review of PA and performance optimization of queueing systems, focusing on a fundamental concept called perturbation realization factors, which captures the special dynamic feature of a queueing system. With the perturbation realization factors as building blocks, the performance derivative formula and performance difference formula can be obtained. With performance derivatives, gradient-based optimization can be derived, while with performance difference, policy iteration and optimality equations can be derived. These two fundamental formulas provide a foundation for performance optimization of queueing systems from a sensitivity-based point of view. We hope this survey may provide some inspirations on this promising research topic. © 2011 Elsevier B.V. All rights reserved.

  16. Optimal control and design of a cold store using dynamic optimization

    NARCIS (Netherlands)

    Lukasse, L.; Broeze, J.; Sluis, S. van der

    2009-01-01

    The design of controlled processes is a combined optimal control and design problem (OCDP). Literature on solving large OCDPs is rare. This paper presents an algorithm for solving large OCDPs. For this algorithm system dynamics, objective function and their first-order derivatives must be continuous

  17. Temperature Scaling Law for Quantum Annealing Optimizers.

    Science.gov (United States)

    Albash, Tameem; Martin-Mayor, Victor; Hen, Itay

    2017-09-15

    Physical implementations of quantum annealing unavoidably operate at finite temperatures. We point to a fundamental limitation of fixed finite temperature quantum annealers that prevents them from functioning as competitive scalable optimizers and show that to serve as optimizers annealer temperatures must be appropriately scaled down with problem size. We derive a temperature scaling law dictating that temperature must drop at the very least in a logarithmic manner but also possibly as a power law with problem size. We corroborate our results by experiment and simulations and discuss the implications of these to practical annealers.

  18. Centralized Stochastic Optimal Control of Complex Systems

    Energy Technology Data Exchange (ETDEWEB)

    Malikopoulos, Andreas [ORNL

    2015-01-01

    In this paper we address the problem of online optimization of the supervisory power management control in parallel hybrid electric vehicles (HEVs). We model HEV operation as a controlled Markov chain using the long-run expected average cost per unit time criterion, and we show that the control policy yielding the Pareto optimal solution minimizes the average cost criterion online. The effectiveness of the proposed solution is validated through simulation and compared to the solution derived with dynamic programming using the average cost criterion.

  19. Optimal Location of an Oil Storage Facility

    Directory of Open Access Journals (Sweden)

    Giovanni Quiel

    2010-01-01

    Full Text Available Given three oil drilling sites, we devise a method to determine the optimal location for a storage facility such that the total length of pipeline required to connect each site to the facility is minimized. First we represent the total distance of piping as the sum of the individual distances between the storage facility and each oil well. From this, both the optimal overall pipeline length and the location of the storage facility which realizes the minimal length can be determined through the first and second partial derivative tests.

  20. Space mapping optimization algorithms for engineering design

    DEFF Research Database (Denmark)

    Koziel, Slawomir; Bandler, John W.; Madsen, Kaj

    2006-01-01

    A simple, efficient optimization algorithm based on space mapping (SM) is presented. It utilizes input SM to reduce the misalignment between the coarse and fine models of the optimized object over a region of interest, and output space mapping (OSM) to ensure matching of response and first......-order derivatives between the mapped coarse model and the fine model at the current iteration point. We also consider an enhanced version in which the input SM coefficients are frequency dependent. The performance of our new algorithms is comparable with the recently published SMIS algorithm when applied...

  1. Validation and optimization of satellite-derived direct solar irradiance from Meteosat. Final report of the BMU-project VALISAT/SOLEMI work package 2; Validierung und Optimierung der satellitengestuetzten Bestimmung solarer Direktstrahlung mit Meteosat. Abschlussbericht zum BMU-Projekt VALISAT/SOLEMI Teilprojekt AP2

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, R.; Lohmann, S. [DLR Deutsches Zentrum fuer Luft- und Raumfahrt e.V., Oberpfaffenhofen (Germany). Inst. fuer Physik der Atmosphaere; Hoyer, C.; Schillings, C. [DLR Deutsches Zentrum fuer Luft- und Raumfahrt e.V., Stuttgart (Germany). Inst. fuer Technische Thermodynamik

    2006-09-15

    A new scheme for derivation of direct normal irradiance based on satellite data is presented. Cloud transmission is estimated from Meteosat. Additionally, model-derived aerosol- and water vapour and satellite-derived optical depth of ozone is taken into account for calculation of radiative transfer. The new procedure is tested thoroughly by radiation measurements worldwide. The spatial resolution was enhanced from formerly 5 km to 2.5km. The main quality improvement reveals from the reduction of the standard deviation of hourly averaged measurements and hourly satellite-derived values. (orig.)

  2. Energy optimization system

    Science.gov (United States)

    Zhou, Zhi; de Bedout, Juan Manuel; Kern, John Michael; Biyik, Emrah; Chandra, Ramu Sharat

    2013-01-22

    A system for optimizing customer utility usage in a utility network of customer sites, each having one or more utility devices, where customer site is communicated between each of the customer sites and an optimization server having software for optimizing customer utility usage over one or more networks, including private and public networks. A customer site model for each of the customer sites is generated based upon the customer site information, and the customer utility usage is optimized based upon the customer site information and the customer site model. The optimization server can be hosted by an external source or within the customer site. In addition, the optimization processing can be partitioned between the customer site and an external source.

  3. Workshop on Computational Optimization

    CERN Document Server

    2015-01-01

    Our everyday life is unthinkable without optimization. We try to minimize our effort and to maximize the achieved profit. Many real world and industrial problems arising in engineering, economics, medicine and other domains can be formulated as optimization tasks. This volume is a comprehensive collection of extended contributions from the Workshop on Computational Optimization 2013. It presents recent advances in computational optimization. The volume includes important real life problems like parameter settings for controlling processes in bioreactor, resource constrained project scheduling, problems arising in transport services, error correcting codes, optimal system performance and energy consumption and so on. It shows how to develop algorithms for them based on new metaheuristic methods like evolutionary computation, ant colony optimization, constrain programming and others.

  4. Homotopy optimization methods for global optimization.

    Energy Technology Data Exchange (ETDEWEB)

    Dunlavy, Daniel M.; O' Leary, Dianne P. (University of Maryland, College Park, MD)

    2005-12-01

    We define a new method for global optimization, the Homotopy Optimization Method (HOM). This method differs from previous homotopy and continuation methods in that its aim is to find a minimizer for each of a set of values of the homotopy parameter, rather than to follow a path of minimizers. We define a second method, called HOPE, by allowing HOM to follow an ensemble of points obtained by perturbation of previous ones. We relate this new method to standard methods such as simulated annealing and show under what circumstances it is superior. We present results of extensive numerical experiments demonstrating performance of HOM and HOPE.

  5. Optimization and Discrete Mathematics

    Science.gov (United States)

    2012-03-06

    Manager AFOSR/RSL Air Force Research Laboratory Optimization and Discrete Mathematics 6 Mar 2012 Report Documentation Page Form ApprovedOMB No...00-2012 to 00-00-2012 4. TITLE AND SUBTITLE Optimization and Discrete Mathematics 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...distribution is unlimited.. Optimization and Discrete Mathematics PM: Don Hearn BRIEF DESCRIPTION OF PORTFOLIO: Development of

  6. Optimization and approximation

    CERN Document Server

    Pedregal, Pablo

    2017-01-01

    This book provides a basic, initial resource, introducing science and engineering students to the field of optimization. It covers three main areas: mathematical programming, calculus of variations and optimal control, highlighting the ideas and concepts and offering insights into the importance of optimality conditions in each area. It also systematically presents affordable approximation methods. Exercises at various levels have been included to support the learning process.

  7. Optimization of Inventory

    OpenAIRE

    PROKOPOVÁ, Nikola

    2017-01-01

    The subject of this thesis is optimization of inventory in selected organization. Inventory optimization is a very important topic in each organization because it reduces storage costs. At the beginning the inventory theory is presented. It shows the meaning and types of inventory, inventory control and also different methods and models of inventory control. Inventory optimization in the enterprise can be reached by using models of inventory control. In the second part the company on which is...

  8. POSTDOC : THE HUMAN OPTIMIZATION

    OpenAIRE

    Satish Gajawada

    2013-01-01

    This paper is dedicated to everyone who is interested in the Artificial Intelligence. John Henry Holland proposed Genetic Algorithm in the early 1970s. Ant Colony Optimization was proposed by Marco Dorigo in 1992. Particle Swarm Optimization was introduced by Kennedy and Eberhart in 1995. Storn and Price introduced Differential Evolution in 1996. K.M. Passino introduced Bacterial Foraging Optimization Algorithm in 2002. In 2003, X.L. Li proposed Artificial Fish Swarm Algorithm....

  9. Logical Stochastic Optimization

    OpenAIRE

    Saad, Emad

    2013-01-01

    We present a logical framework to represent and reason about stochastic optimization problems based on probability answer set programming. This is established by allowing probability optimization aggregates, e.g., minimum and maximum in the language of probability answer set programming to allow minimization or maximization of some desired criteria under the probabilistic environments. We show the application of the proposed logical stochastic optimization framework under the probability answ...

  10. Smoothers for Optimization Problems

    Science.gov (United States)

    Arian, Eyal; Ta'asan, Shlomo

    1996-01-01

    We present a multigrid one-shot algorithm, and a smoothing analysis, for the numerical solution of optimal control problems which are governed by an elliptic PDE. The analysis provides a simple tool to determine a smoothing minimization process which is essential for multigrid application. Numerical results include optimal control of boundary data using different discretization schemes and an optimal shape design problem in 2D with Dirichlet boundary conditions.

  11. ASTEROID LIGHTCURVE DERIVED DATA

    Data.gov (United States)

    National Aeronautics and Space Administration — This is a compilation of published rotational parameters derived from lightcurve data for asteroids, based on the Warner et al. (2009) Asteroid Lightcurve Database....

  12. Teaching Cournot without Derivatives.

    Science.gov (United States)

    Dufwenberg, Martin

    2001-01-01

    Presents a simple technique for teaching the Cournot model to first-year microeconomic students. Involves demonstrating, without the use of derivatives, that out of all rectangles with a common perimeter, the square has the greatest area. (RLH)

  13. The azobenzene derivatives

    Science.gov (United States)

    Ionita, Ionica; Radulescu, Cristiana; Poinescu, Aurora Anca; Anghelina, Florina Violeta; Bunghez, Raluca; Ion, Rodica-Mariana

    2015-02-01

    Azobenzene derivatives constitute a group of dyes which have photochromic properties and have been investigated as promising systems for diverse applications in the unconventional optic area, their properties can be moulded with help of light.

  14. Amphetamine derivative related deaths.

    Science.gov (United States)

    Lora-Tamayo, C; Tena, T; Rodríguez, A

    1997-02-28

    Amphetamine its methylendioxy (methylendioxyamphetamine methylenedioxymethylamphetamine, methylenedioxyethylamphetamine) and methoxy derivatives (p-methoxyamphetamine and p-methoxymethylamphetamine) are widely abused in Spanish society. We present here the results of a systematic study of all cases of deaths brought to the attention of the Madrid department of the Instituto Nacional de Toxicologia from 1993 to 1995 in which some of these drugs have been found in the cadaveric blood. The cases were divided into three categories: amphetamine and derivatives, amphetamines and alcohol, amphetamines and other drugs. Data on age, sex, clinical symptoms, morphological findings, circumstances of death, when known, and concentration of amphetamine derivatives, alcohol and other drugs in blood are given for each group. The information provided here may prove to be useful for the forensic interpretation of deaths which are directly or indirectly related to abuse of amphetamine derivatives.

  15. A New Approach for Optimal Sizing of Standalone Photovoltaic Systems

    Directory of Open Access Journals (Sweden)

    Tamer Khatib

    2012-01-01

    Full Text Available This paper presents a new method for determining the optimal sizing of standalone photovoltaic (PV system in terms of optimal sizing of PV array and battery storage. A standalone PV system energy flow is first analysed, and the MATLAB fitting tool is used to fit the resultant sizing curves in order to derive general formulas for optimal sizing of PV array and battery. In deriving the formulas for optimal sizing of PV array and battery, the data considered are based on five sites in Malaysia, which are Kuala Lumpur, Johor Bharu, Ipoh, Kuching, and Alor Setar. Based on the results of the designed example for a PV system installed in Kuala Lumpur, the proposed method gives satisfactory optimal sizing results.

  16. Control and optimization system

    Science.gov (United States)

    Xinsheng, Lou

    2013-02-12

    A system for optimizing a power plant includes a chemical loop having an input for receiving an input parameter (270) and an output for outputting an output parameter (280), a control system operably connected to the chemical loop and having a multiple controller part (230) comprising a model-free controller. The control system receives the output parameter (280), optimizes the input parameter (270) based on the received output parameter (280), and outputs an optimized input parameter (270) to the input of the chemical loop to control a process of the chemical loop in an optimized manner.

  17. Introduction to Continuous Optimization

    DEFF Research Database (Denmark)

    Andreasson, Niclas; Evgrafov, Anton; Patriksson, Michael

    Optimization, or mathematical programming, is a fundamental subject within decision science and operations research, in which mathematical decision models are constructed, analyzed, and solved. The book’s focus lies on providing a basis for the analysis of optimization models and of candidate opt......, 2005, edition. The book can be used in mathematical optimization courses at any mathematics, engineering, economics, and business schools. It is a perfect starting book for anyone who wishes to develop his/her understanding of the subject of optimization, before actually applying it....

  18. Stochastic optimization methods

    CERN Document Server

    Marti, Kurt

    2008-01-01

    Optimization problems arising in practice involve random model parameters. This book features many illustrations, several examples, and applications to concrete problems from engineering and operations research.

  19. Integer and combinatorial optimization

    CERN Document Server

    Nemhauser, George L

    1999-01-01

    Rave reviews for INTEGER AND COMBINATORIAL OPTIMIZATION ""This book provides an excellent introduction and survey of traditional fields of combinatorial optimization . . . It is indeed one of the best and most complete texts on combinatorial optimization . . . available. [And] with more than 700 entries, [it] has quite an exhaustive reference list.""-Optima ""A unifying approach to optimization problems is to formulate them like linear programming problems, while restricting some or all of the variables to the integers. This book is an encyclopedic resource for such f

  20. Optimization : insights and applications

    CERN Document Server

    Brinkhuis, Jan

    2005-01-01

    This self-contained textbook is an informal introduction to optimization through the use of numerous illustrations and applications. The focus is on analytically solving optimization problems with a finite number of continuous variables. In addition, the authors provide introductions to classical and modern numerical methods of optimization and to dynamic optimization. The book's overarching point is that most problems may be solved by the direct application of the theorems of Fermat, Lagrange, and Weierstrass. The authors show how the intuition for each of the theoretical results can be s

  1. Deterministic Global Optimization

    CERN Document Server

    Scholz, Daniel

    2012-01-01

    This monograph deals with a general class of solution approaches in deterministic global optimization, namely the geometric branch-and-bound methods which are popular algorithms, for instance, in Lipschitzian optimization, d.c. programming, and interval analysis.It also introduces a new concept for the rate of convergence and analyzes several bounding operations reported in the literature, from the theoretical as well as from the empirical point of view. Furthermore, extensions of the prototype algorithm for multicriteria global optimization problems as well as mixed combinatorial optimization

  2. Sequential stochastic optimization

    CERN Document Server

    Cairoli, Renzo

    1996-01-01

    Sequential Stochastic Optimization provides mathematicians and applied researchers with a well-developed framework in which stochastic optimization problems can be formulated and solved. Offering much material that is either new or has never before appeared in book form, it lucidly presents a unified theory of optimal stopping and optimal sequential control of stochastic processes. This book has been carefully organized so that little prior knowledge of the subject is assumed; its only prerequisites are a standard graduate course in probability theory and some familiarity with discrete-paramet

  3. Optimization under Uncertainty

    KAUST Repository

    Lopez, Rafael H.

    2016-01-06

    The goal of this poster is to present the main approaches to optimization of engineering systems in the presence of uncertainties. We begin by giving an insight about robust optimization. Next, we detail how to deal with probabilistic constraints in optimization, the so called the reliability based design. Subsequently, we present the risk optimization approach, which includes the expected costs of failure in the objective function. After that the basic description of each approach is given, the projects developed by CORE are presented. Finally, the main current topic of research of CORE is described.

  4. Maximal imaginery eigenvalues in optimal systems

    Directory of Open Access Journals (Sweden)

    David Di Ruscio

    1991-07-01

    Full Text Available In this note we present equations that uniquely determine the maximum possible imaginary value of the closed loop eigenvalues in an LQ-optimal system, irrespective of how the state weight matrix is chosen, provided a real symmetric solution of the algebraic Riccati equation exists. In addition, the corresponding state weight matrix and the solution to the algebraic Riccati equation are derived for a class of linear systems. A fundamental lemma for the existence of a real symmetric solution to the algebraic Riccati equation is derived for this class of linear systems.

  5. Brain derived neurotrophic factor

    DEFF Research Database (Denmark)

    Mitchelmore, Cathy; Gede, Lene

    2014-01-01

    Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies are curre......Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies...

  6. Granin-derived peptides.

    Science.gov (United States)

    Troger, Josef; Theurl, Markus; Kirchmair, Rudolf; Pasqua, Teresa; Tota, Bruno; Angelone, Tommaso; Cerra, Maria C; Nowosielski, Yvonne; Mätzler, Raphaela; Troger, Jasmin; Gayen, Jaur R; Trudeau, Vance; Corti, Angelo; Helle, Karen B

    2017-07-01

    The granin family comprises altogether 7 different proteins originating from the diffuse neuroendocrine system and elements of the central and peripheral nervous systems. The family is dominated by three uniquely acidic members, namely chromogranin A (CgA), chromogranin B (CgB) and secretogranin II (SgII). Since the late 1980s it has become evident that these proteins are proteolytically processed, intragranularly and/or extracellularly into a range of biologically active peptides; a number of them with regulatory properties of physiological and/or pathophysiological significance. The aim of this comprehensive overview is to provide an up-to-date insight into the distribution and properties of the well established granin-derived peptides and their putative roles in homeostatic regulations. Hence, focus is directed to peptides derived from the three main granins, e.g. to the chromogranin A derived vasostatins, betagranins, pancreastatin and catestatins, the chromogranin B-derived secretolytin and the secretogranin II-derived secretoneurin (SN). In addition, the distribution and properties of the chromogranin A-derived peptides prochromacin, chromofungin, WE14, parastatin, GE-25 and serpinins, the CgB-peptide PE-11 and the SgII-peptides EM66 and manserin will also be commented on. Finally, the opposing effects of the CgA-derived vasostatin-I and catestatin and the SgII-derived peptide SN on the integrity of the vasculature, myocardial contractility, angiogenesis in wound healing, inflammatory conditions and tumors will be discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Optimization Models for Petroleum Field Exploitation

    Energy Technology Data Exchange (ETDEWEB)

    Jonsbraaten, Tore Wiig

    1998-12-31

    This thesis presents and discusses various models for optimal development of a petroleum field. The objective of these optimization models is to maximize, under many uncertain parameters, the project`s expected net present value. First, an overview of petroleum field optimization is given from the point of view of operations research. Reservoir equations for a simple reservoir system are derived and discretized and included in optimization models. Linear programming models for optimizing production decisions are discussed and extended to mixed integer programming models where decisions concerning platform, wells and production strategy are optimized. Then, optimal development decisions under uncertain oil prices are discussed. The uncertain oil price is estimated by a finite set of price scenarios with associated probabilities. The problem is one of stochastic mixed integer programming, and the solution approach is to use a scenario and policy aggregation technique developed by Rockafellar and Wets although this technique was developed for continuous variables. Stochastic optimization problems with focus on problems with decision dependent information discoveries are also discussed. A class of ``manageable`` problems is identified and an implicit enumeration algorithm for finding optimal decision policy is proposed. Problems involving uncertain reservoir properties but with a known initial probability distribution over possible reservoir realizations are discussed. Finally, a section on Nash-equilibrium and bargaining in an oil reservoir management game discusses the pool problem arising when two lease owners have access to the same underlying oil reservoir. Because the oil tends to migrate, both lease owners have incentive to drain oil from the competitors part of the reservoir. The discussion is based on a numerical example. 107 refs., 31 figs., 14 tabs.

  8. OPTIMIZATION OF OPTIMIZATION OF DESIGN FORMULA DESIGN ...

    African Journals Online (AJOL)

    User

    control in productions both at the fac the site. Thus, optimum desig approached from a global appl starting initially from the optim individual units or criterion. The method [12, 13, 14, 15] is used herein the ultimate limit-state of bending reinforced concrete slab. presented herein have been develop mathematical programming.

  9. PID control for chaotic synchronization using particle swarm optimization

    Energy Technology Data Exchange (ETDEWEB)

    Chang, W.-D. [Department of Computer and Communication, Shu-Te University, Kaohsiung 824, Taiwan (China)], E-mail: wdchang@mail.stu.edu.tw

    2009-01-30

    In this paper, we attempt to use the proportional-integral-derivative (PID) controller to achieve the chaos synchronization for delayed discrete chaotic systems. Three PID control gains can be optimally determined by means of using a novel optimization algorithm, called the particle swarm optimization (PSO). The algorithm is motivated from the organism behavior of fish schooling and bird flocking, and involves the social psychology principles in socio-cognition human agents and evolutionary computations. It has a good numerical convergence for solving optimization problem. To show the validity of the PSO-based PID control for chaos synchronization, several cases with different initial populations are considered and some simulation results are shown.

  10. A Multiobjective Optimization Framework for Stochastic Control of Complex Systems

    Energy Technology Data Exchange (ETDEWEB)

    Malikopoulos, Andreas [ORNL; Maroulas, Vasileios [ORNL; Xiong, Professor Jie [The University of Tennessee

    2015-01-01

    This paper addresses the problem of minimizing the long-run expected average cost of a complex system consisting of subsystems that interact with each other and the environment. We treat the stochastic control problem as a multiobjective optimization problem of the one-stage expected costs of the subsystems, and we show that the control policy yielding the Pareto optimal solution is an optimal control policy that minimizes the average cost criterion for the entire system. For practical situations with constraints consistent to those we study here, our results imply that the Pareto control policy may be of value in deriving online an optimal control policy in complex systems.

  11. Linear Programming and Genetic Algorithm Based Optimization for the Weighting Scheme of a Value Focused Thinking Hierarchy

    National Research Council Canada - National Science Library

    Thawley, David

    2003-01-01

    .... When historical data exists on evaluation measures and performance of alternatives, linear programming and genetic algorithm based optimization may be used to derive historically optimal weights for a hierarchy...

  12. Optimal control of radiator systems; Optimal reglering av radiatorsystem

    Energy Technology Data Exchange (ETDEWEB)

    Wollerstrand, J.; Ljunggren, P.; Johansson, P.O.

    2007-07-01

    This report presents results from a study aiming to considerably improve the development towards minimizing the primary return temperature from a district heating (DH) substation by optimizing the control algorithm for the space heating system. The investigation of this research field started about 20 years ago in Sweden when low flow operation of space heating systems was introduced. Following a couple of years of partly confused discussions, the method was accepted by many, but was rejected by others. Our thesis is that further improvement of cooling of DH water is possible when advanced, but robust, control algorithms are used for the space heating system. A space heating system is traditionally designed for a specific constant circulation flow combined with a suitable control curve for the space heating supply temperature as a function of the outdoor temperature. Optimal choice of the control curve varies from case to case and is an issue both we and others have dealt with in previous work. A large step was to derive theoretical control curves for optimal control of the space heating system, with an analysis of how temperature and circulation flow varies with heat load. The estimated gain varies strongly depending on the conditions, however, with realistic conditions it can be as much as 5 deg C decreased DH return temperature on yearly average. To be able to work properly under varying physical circumstances, a control algorithm must be able to combine variation of space heating supply temperature and circulation flow as a function of the heat load. By regulating the rotation speed of the circulation pump this can be achieved. Such regulation can be adjusted for each and every building by regulating a few parameters in a regulator. The results from this work are, that important theoretical knowledge has been completed, to show results systematically and to find support from practical experiments. A hands-on description of the method for optimizing DH water

  13. Optimizing the Frequency of Quantum Error Correction

    Science.gov (United States)

    Abu-Nada, Ali; Fortescue, Ben; Byrd, Mark

    2017-11-01

    A common assumption is that one applies a fault-tolerant quantum error correction (FTQEC) after every gate during quantum computing. However, it is known that this is not always optimal, since the FTQEC procedure itself can introduce errors. Here we vary the number of logical gates between FTQEC operations given that a failure of a postselection condition may cause the FTQEC to be skipped. We derive an expression for the logical error rate as a function of the error-correction frequency and find the optimal frequency for the application of the FTQEC. Furthermore, we show that this is relatively insensitive to the postselection failure probability for a large range of such probabilities. We provide an example of the application of the analytic expression to the ⟦ 7 ,1 ,3 ⟧ Steane code and data derived from a Monte Carlo simulation.

  14. Optimization of multiple flyby trajectories

    Science.gov (United States)

    Damario, L. A.; Sackett, L. L.; Stanford, R. H.; Byrnes, D. V.

    1979-01-01

    A procedure has been developed which minimizes total delta-V (instantaneous velocity change) for a multiple flyby trajectory with constraints on flyby altitude and orientation. The solution is found by varying the locations of maneuver points between each flyby to minimize the delta-Vs at the maneuver points. Each trajectory segment connecting consecutive maneuver points is found by solving an N-body analog to Lambert's problem. Multiconic techniques are used for trajectory propagation and for computation of the state transition matrix. The constrained parameter optimization problem is converted to an unconstrained problem by means of penalty functions and then solved with a quasi-Newton algorithm utilizing analytic first derivatives. This procedure has been successfully applied to Galileo satellite tour trajectories.

  15. Topology optimization of pulse shaping filters using the Hilbert transform envelope extraction

    DEFF Research Database (Denmark)

    Lazarov, Boyan Stefanov; Matzen, René; Elesin, Yuriy

    2011-01-01

    Time domain topology optimization is applied to design pulse shaping filters. The objective function depends on the pulse envelope, which is extracted by utilizing the Hilbert transform. The gradients with respect to the topology optimization variables are derived, and the optimization methodology...

  16. Optimal Power Allocation Algorithm for Radar Network Systems Based on Low Probability of Intercept Optimization(in English

    Directory of Open Access Journals (Sweden)

    Shi Chen-guang

    2014-08-01

    Full Text Available A novel optimal power allocation algorithm for radar network systems is proposed for Low Probability of Intercept (LPI technology in modern electronic warfare. The algorithm is based on the LPI optimization. First, the Schleher intercept factor for a radar network is derived, and then the Schleher intercept factor is minimized by optimizing the transmission power allocation among netted radars in the network to guarantee target-tracking performance. Furthermore, the Nonlinear Programming Genetic Algorithm (NPGA is used to solve the resulting nonconvex, nonlinear, and constrained optimization problem. Numerical simulation results show the effectiveness of the proposed algorithm.

  17. Symbiotic Optimization of Behavior

    Science.gov (United States)

    2015-05-01

    SYMBIOTIC OPTIMIZATION OF BEHAVIOR UNIVERSITY OF WASHINGTON MAY 2015 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED...2014 4. TITLE AND SUBTITLE SYMBIOTIC OPTIMIZATION OF BEHAVIOR 5a. CONTRACT NUMBER FA8750-12-1-0304 5b. GRANT NUMBER N/A 5c. PROGRAM ELEMENT

  18. Optimization in power systems

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Geraldo R.M. da [Sao Paulo Univ., Sao Carlos, SP (Brazil). Escola de Engenharia

    1994-12-31

    This paper discusses, partially, the advantages and the disadvantages of the optimal power flow. It shows some of the difficulties of implementation and proposes solutions. An analysis is made comparing the power flow, BIGPOWER/CESP, and the optimal power flow, FPO/SEL, developed by the author, when applied to the CEPEL-ELETRONORTE and CESP systems. (author) 8 refs., 5 tabs.

  19. Constructive optimality theoretic syntax

    NARCIS (Netherlands)

    Zeevat, H.; Villadsen, J.; Christiansen, H.

    2008-01-01

    This paper documents efforts at developing a constructive optimality theory. Several years ago, two 3rd year AI-students, Chris Regenboog and Jacco van Willegen, came up with an idea to implement optimality theory, in a special case —a system partially describing Dutch word order—. Me and some

  20. Optimal Gaussian Filter for Effective Noise Filtering

    OpenAIRE

    Kopparapu, Sunil; Satish, M

    2014-01-01

    In this paper we show that the knowledge of noise statistics contaminating a signal can be effectively used to choose an optimal Gaussian filter to eliminate noise. Very specifically, we show that the additive white Gaussian noise (AWGN) contaminating a signal can be filtered best by using a Gaussian filter of specific characteristics. The design of the Gaussian filter bears relationship with the noise statistics and also some basic information about the signal. We first derive a relationship...

  1. Strong Coupling Optimization With Planar Spiral Resonators

    CERN Document Server

    Klein, Avraham; 10.1016/j.cap.2011.02.017

    2011-01-01

    Planar spirals offer a highly scalable geometry appropriate for wireless power transfer via strongly coupled inductive resonators. We numerically derive a set of geometric scale and material independent coupling terms, and analyze a simple model to identify design considerations for a variety of different materials. We use our model to fabricate integrated planar resonators of handheld sizes, and optimize them to achieve high Q factors, comparable to much larger systems, and strong coupling over significant distances with approximately constant efficiency.

  2. Optimal Portfolios Under Dynamic Shortfall Constraints

    African Journals Online (AJOL)

    θt , subject to the terminal condition J(v, T) = Н(v), where. J, the value function is given by. J(ι, t) = sup. { }e (Ъ). EШ Ъ. {∫ М. Ш e. - ×U(c×)ds + e. - М U(VШ ). } ,. (8) where subscripts on J denote partial derivatives and V ,c t. = v, the wealth realization at time t. In solving the HJB equation (7), the static optimization problem max.

  3. Workshop on Computational Optimization

    CERN Document Server

    2016-01-01

    This volume is a comprehensive collection of extended contributions from the Workshop on Computational Optimization 2014, held at Warsaw, Poland, September 7-10, 2014. The book presents recent advances in computational optimization. The volume includes important real problems like parameter settings for controlling processes in bioreactor and other processes, resource constrained project scheduling, infection distribution, molecule distance geometry, quantum computing, real-time management and optimal control, bin packing, medical image processing, localization the abrupt atmospheric contamination source and so on. It shows how to develop algorithms for them based on new metaheuristic methods like evolutionary computation, ant colony optimization, constrain programming and others. This research demonstrates how some real-world problems arising in engineering, economics, medicine and other domains can be formulated as optimization tasks.

  4. Modern optimization with R

    CERN Document Server

    Cortez, Paulo

    2014-01-01

    The goal of this book is to gather in a single document the most relevant concepts related to modern optimization methods, showing how such concepts and methods can be addressed using the open source, multi-platform R tool. Modern optimization methods, also known as metaheuristics, are particularly useful for solving complex problems for which no specialized optimization algorithm has been developed. These methods often yield high quality solutions with a more reasonable use of computational resources (e.g. memory and processing effort). Examples of popular modern methods discussed in this book are: simulated annealing; tabu search; genetic algorithms; differential evolution; and particle swarm optimization. This book is suitable for undergraduate and graduate students in Computer Science, Information Technology, and related areas, as well as data analysts interested in exploring modern optimization methods using R.

  5. SAGD optimization under uncertainty

    Energy Technology Data Exchange (ETDEWEB)

    Gossuin, J.; Naccache, P. [Schlumberger SIS, Abingdon (United Kingdom); Bailley, W.; Couet, B. [Schlumberger-Doll Research, Cambridge, MA, (United States)

    2011-07-01

    In the heavy oil industry, the steam assisted gravity drainage process is often used to enhance oil recovery but this is a costly method and ways to make it more efficient are needed. Multiple methods have been developed to optimize the SAGD process but none of them explicitly considered uncertainty. This paper presents an optimization method in the presence of reservoir uncertainty. This process was tested on an SAGD model where three equi-probable geological models are possible. Preparatory steps were first performed to identify key variables and the optimization model was then proposed. The method was shown to be successful in handling a significant number of uncertainties, optimizing the SAGD process and preventing premature steam channels that can choke production. The optimization method presented herein was successfully applied to an SAGD process and was shown to provide better strategies than sensitivity analysis while handling more complex problems.

  6. Overall bolt stress optimization

    DEFF Research Database (Denmark)

    Pedersen, Niels Leergaard

    2013-01-01

    The state of stress in bolts and nuts with International Organization for Standardization metric thread design is examined and optimized. The assumed failure mode is fatigue, so the applied preload and the load amplitude together with the stress concentrations define the connection strength....... Maximum stress in the bolt is found at the fillet under the head, at the thread start, or at the thread root. To minimize the stress concentration, shape optimization is applied. Nut shape optimization also has a positive effect on the maximum stress. The optimization results show that designing a nut......, which results in a more evenly distribution of load along the engaged thread, has a limited influence on the maximum stress due to the stress concentration at the first thread root. To further reduce the maximum stress, the transition from bolt shank to the thread must be optimized. Stress reduction...

  7. Optimized manufacturable porous materials

    DEFF Research Database (Denmark)

    Andreassen, Erik; Andreasen, Casper Schousboe; Jensen, Jakob Søndergaard

    to include manufacturing constraints in the optimization. This work focuses on incorporating the manufacturability into the optimization procedure, allowing the resulting material structure to be manufactured directly using rapid manufacturing techniques, such as selective laser melting/sintering (SLM....../S). The available manufacturing methods are best suited for porous materials (one constituent and void), but the optimization procedure can easily include more constituents. The elasticity tensor is found from one unit cell using the homogenization method together with a standard finite element (FE) discretization....... The distribution of the material in the unit cell is optimized according to a given objective (e.g. maximum bulk modulus or minimum Poisson’s ratio) and some given constraints (e.g. isotropy) using topology optimization. The manufacturability is achieved using various filtering techniques together...

  8. Semisynthetic Derivatives of Epothilones

    Science.gov (United States)

    Altmann, Karl-Heinz

    Semisynthetic derivatives of natural products traditionally occupy a prominent space in natural-product-based drug discovery (1, 2). As many biologically active natural products exhibit a high degree of structural complexity (3), the chemical derivatization of material isolated from natural sources often represents the only feasible means (or at least the only economically viable approach) to explore structure-activity-relationships (SAR) and to produce analogs with more favorable pharmacokinetic and pharmacological properties than the natural product lead. Examples of clinically important drugs that are semisynthetic derivatives of natural products exist in virtually all disease areas (1, 2); in the treatment of cancer this includes compounds such as etoposide or teniposide (derived from podophyllotoxin) (4-6), irinotecan and topotecan (derived from camptothecin) (7-9), or docetaxel (derived from 10-deacetylbaccatin III) (10, 11). Even for taxol (11), which is a natural product (12), the sustained supply of sufficient quantities of material for widespread clinical use could only be secured through the development of a semisynthetic production process from another natural product, namely, 10-deacetylbaccatin III (13). In light of these facts, it is not surprising that semisynthesis approaches have also featured prominently in the elucidation of the SAR for epothilones and in the discovery of a number of clinical development candidates.

  9. Environmental study for optimal sites selection for incineration plant of refuse derived fuel in Lucca Province, Tuscany (Italy); Metodologie e tecniche di analisi ambientale per l`ubicazione `sostenibile` di impianti di smaltimento rifiuti: l`esperienza della Provincia di Lucca

    Energy Technology Data Exchange (ETDEWEB)

    Tassoni, E; Cautilli, F.; Polizzano, C.; Andriola, L. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Ambiente

    1998-04-01

    The present report describes the methodology and the main results of an environmental study aimed at the selection of the optimal sites for incineration plant of Refuse Derived Fuel (RDF) and the associated waste disposal landfill, in a defined territory. The study was commissioned by a local administrative Authority (Province of Lucca, northern Tuscany, Italy), and was carried out according to the indications of the `EEC Political Program of Action in favour of the environment and of a sustainable development`. In essence, the methodology takes into account both the major and extant descriptive elements of the environment under scrutiny, and the project main elements of the proposed plant. Additionally, considerations were included regarding the location of all the segments of the entire disposal plant, particularly the disposal landfill which is usually responsible for the greatest environmental impact. Finally, the results were compared with the limits indicated by the present regulations. Similar methods, were previously applied to different territories, and are still in progress. In order to estimate the fate of the air bone discharges from the incinerator into the selected potential area, a meteorological and diffusive study was undertaken to calculate the average annual levels by depositions on ground through dry and wet mechanisms. By comparison with the regulatory limits imposed to the stack emissions by the EEC Directives, the calculated ground level depositions were considerably lower. By taking into account a number of environmental features (such as the subjection of water-bearing layers, low risk of modification of ecological processes, low impact on the agricultural activities), of logistic reasons (large average extension to allow the location of all plants), and socio-economic elements (presence of large industrial plants, lower density of housing distribution), 14 sub-areas were identified and selected, mainly concentrated in the central

  10. Derivations and evaluations

    NARCIS (Netherlands)

    Broekhuis, H.; Broekhuis, H.; Vogel, R.

    2013-01-01

    This chapter departs from the observation that the minimalist framework and optimality theory adopt the same overall architecture of grammar (see also the Introduction): they both assume that a generator defines a set S of potentially wellformed expressions that can be generated on the basis of a

  11. Evolutionary optimization of protein folding.

    Directory of Open Access Journals (Sweden)

    Cédric Debès

    Full Text Available Nature has shaped the make up of proteins since their appearance, [Formula: see text]3.8 billion years ago. However, the fundamental drivers of structural change responsible for the extraordinary diversity of proteins have yet to be elucidated. Here we explore if protein evolution affects folding speed. We estimated folding times for the present-day catalog of protein domains directly from their size-modified contact order. These values were mapped onto an evolutionary timeline of domain appearance derived from a phylogenomic analysis of protein domains in 989 fully-sequenced genomes. Our results show a clear overall increase of folding speed during evolution, with known ultra-fast downhill folders appearing rather late in the timeline. Remarkably, folding optimization depends on secondary structure. While alpha-folds showed a tendency to fold faster throughout evolution, beta-folds exhibited a trend of folding time increase during the last [Formula: see text]1.5 billion years that began during the "big bang" of domain combinations. As a consequence, these domain structures are on average slow folders today. Our results suggest that fast and efficient folding of domains shaped the universe of protein structure. This finding supports the hypothesis that optimization of the kinetic and thermodynamic accessibility of the native fold reduces protein aggregation propensities that hamper cellular functions.

  12. Optimality Criterion Methods in Structural Optimization.

    Science.gov (United States)

    1982-10-01

    Project Engineer Chf , Analysis & Optimization Branch Design & Analysis Methods Group RAL L. KUSTER, 3.,gol, USAF CisStructures & [amics Division "If...IITI II * *I *e * lI I imo 31m 2 -I "’ II I I I I I OI .4 a 0 I IO O * o2 me * me ecg m m o e o omo em me m e *e 0, ~ 𔄂l 𔄂 II 01 I IO OI II ~ ’ 8 8

  13. Judo Biomechanical Optimization

    CERN Document Server

    Sacripanti, Attilio

    2016-01-01

    In this paper, for the first time, there is comprehensively tackling the problem of biomechanical optimization of a sport of situation such as judo. Starting from the optimization of more simple sports, optimization of this kind of complex sports is grounded on a general physics tool such as the analysis of variation. The objective function is divided for static and dynamic situation of Athletes couple, and it is proposed also a sort of dynamic programming problem Strategic Optimization. A dynamic programming problem is an optimization problem in which decisions have to be taken sequentially over several time periods linked in some fashion. A strategy for a dynamic programming problem is just a contingency plan, a plan that specifies what is to be done at each stage as a function of all that has transpired up to that point. It is possible to demonstrate, under some conditions, that a Markovian optimal strategy is an optimal strategy for the dynamic programming problem under examination. At last we try to appr...

  14. 4th Optimization Day

    CERN Document Server

    Eberhard, Andrew; Ralph, Daniel; Glover, Barney M

    1999-01-01

    Although the monograph Progress in Optimization I: Contributions from Aus­ tralasia grew from the idea of publishing a proceedings of the Fourth Optimiza­ tion Day, held in July 1997 at the Royal Melbourne Institute of Technology, the focus soon changed to a refereed volume in optimization. The intention is to publish a similar book annually, following each Optimization Day. The idea of having an annual Optimization Day was conceived by Barney Glover; the first of these Optimization Days was held in 1994 at the University of Ballarat. Barney hoped that such a yearly event would bring together the many, but widely dispersed, researchers in Australia who were publishing in optimization and related areas such as control. The first Optimization Day event was followed by similar conferences at The University of New South Wales (1995), The University of Melbourne (1996), the Royal Melbourne Institute of Technology (1997), and The University of Western Australia (1998). The 1999 conference will return to Ballarat ...

  15. Multi-Objective Optimization in Physical Synthesis of Integrated Circuits

    CERN Document Server

    A Papa, David

    2013-01-01

    This book introduces techniques that advance the capabilities and strength of modern software tools for physical synthesis, with the ultimate goal to improve the quality of leading-edge semiconductor products.  It provides a comprehensive introduction to physical synthesis and takes the reader methodically from first principles through state-of-the-art optimizations used in cutting edge industrial tools. It explains how to integrate chip optimizations in novel ways to create powerful circuit transformations that help satisfy performance requirements. Broadens the scope of physical synthesis optimization to include accurate transformations operating between the global and local scales; Integrates groups of related transformations to break circular dependencies and increase the number of circuit elements that can be jointly optimized to escape local minima;  Derives several multi-objective optimizations from first observations through complete algorithms and experiments; Describes integrated optimization te...

  16. A Collaborative Neurodynamic Approach to Multiple-Objective Distributed Optimization.

    Science.gov (United States)

    Yang, Shaofu; Liu, Qingshan; Wang, Jun

    2017-02-01

    This paper is concerned with multiple-objective distributed optimization. Based on objective weighting and decision space decomposition, a collaborative neurodynamic approach to multiobjective distributed optimization is presented. In the approach, a system of collaborative neural networks is developed to search for Pareto optimal solutions, where each neural network is associated with one objective function and given constraints. Sufficient conditions are derived for ascertaining the convergence to a Pareto optimal solution of the collaborative neurodynamic system. In addition, it is proved that each connected subsystem can generate a Pareto optimal solution when the communication topology is disconnected. Then, a switching-topology-based method is proposed to compute multiple Pareto optimal solutions for discretized approximation of Pareto front. Finally, simulation results are discussed to substantiate the performance of the collaborative neurodynamic approach. A portfolio selection application is also given.

  17. Optimal Strategy in Basketball

    CERN Document Server

    Skinner, Brian

    2015-01-01

    This book chapter reviews some of the major principles associated with optimal strategy in basketball. In particular, we consider the principles of allocative efficiency (optimal allocation of shots between offensive options), dynamic efficiency (optimal shot selection in the face of pressure from the shot clock), and the risk/reward tradeoff (strategic manipulation of outcome variance). For each principle, we provide a simple example of a strategic problem and show how it can be described analytically. We then review general analytical results and provide an overview of existing statistical studies. A number of open challenges in basketball analysis are highlighted.

  18. Thermophotovoltaic Array Optimization

    Energy Technology Data Exchange (ETDEWEB)

    SBurger; E Brown; K Rahner; L Danielson; J Openlander; J Vell; D Siganporia

    2004-07-29

    A systematic approach to thermophotovoltaic (TPV) array design and fabrication was used to optimize the performance of a 192-cell TPV array. The systematic approach began with cell selection criteria that ranked cells and then matched cell characteristics to maximize power output. Following cell selection, optimization continued with an array packaging design and fabrication techniques that introduced negligible electrical interconnect resistance and minimal parasitic losses while maintaining original cell electrical performance. This paper describes the cell selection and packaging aspects of array optimization as applied to fabrication of a 192-cell array.

  19. Agent-Based Optimization

    CERN Document Server

    Jędrzejowicz, Piotr; Kacprzyk, Janusz

    2013-01-01

    This volume presents a collection of original research works by leading specialists focusing on novel and promising approaches in which the multi-agent system paradigm is used to support, enhance or replace traditional approaches to solving difficult optimization problems. The editors have invited several well-known specialists to present their solutions, tools, and models falling under the common denominator of the agent-based optimization. The book consists of eight chapters covering examples of application of the multi-agent paradigm and respective customized tools to solve  difficult optimization problems arising in different areas such as machine learning, scheduling, transportation and, more generally, distributed and cooperative problem solving.

  20. Optimization of Antivirus Software

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The paper describes the main techniques used in development of computer antivirus software applications. For this particular category of software, are identified and defined optimum criteria that helps determine which solution is better and what are the objectives of the optimization process. From the general viewpoint of software optimization are presented methods and techniques that are applied at code development level. Regarding the particularities of antivirus software, the paper analyzes some of the optimization concepts applied to this category of applications

  1. Optimization for communications and networks

    CERN Document Server

    Saengudomlert, Poompat

    2011-01-01

    PrefaceList of FiguresIntroductionComponents of Optimization ProblemsClasses of Optimization ProblemsConvex OptimizationConvex Sets and Convex FunctionsProperties of Convex OptimizationFurther Properties of Convex SetsDual ProblemsLagrange MultipliersPrimal-Dual Optimality ConditionsSensitivity AnalysisNotes on Maximization ProblemsNumerical Algorithms for Unconstrained OptimizationNumerical Algorithms for Constrained OptimizationApplication: Transmit Power AllocationApplication: Minimum Delay RoutingExercise ProblemsLinear OptimizationIllustrative ExampleProperties of Linear Optimization Prob

  2. amino acid derivatives

    Indian Academy of Sciences (India)

    VENU KANDULA

    tor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry. Biochem. Biophys. Res. Commun. 249 481. 8. Hoult J R S, Moroney M A and Paya M 1994. Actions of flavonoids and coumarins on lipoxygenase and cyclooxygenase Methods. Enzymol. 234 443. 9. Parmar V S ...

  3. Original and Derived Judgment

    DEFF Research Database (Denmark)

    Foss, Kirsten; Foss, Nicolai Juul; Klein, Peter G.

    may delegate a wide range of decision rights to subordinates, who exercise derived judgment. We call these employees "proxy-entrepreneurs," and ask how the firm's or-ganizational structure — its formal and informal systems of rewards and punishments, rules for settling disputes and renegotiating...

  4. Original and Derived Judgment

    DEFF Research Database (Denmark)

    Foss, Kirsten; Foss, Nicolai Juul; Klein, Peter G.

    2007-01-01

    to subordinates, who exercise derived judgment. We call these employees `proxy-entrepreneurs', and ask how the firm's organizational structure - its formal and informal systems of rewards and punishments, rules for settling disputes and renegotiating agreements, means of evaluating performance and so on - can...

  5. Food derived carcinogenic amnoimidazoazaarenes

    DEFF Research Database (Denmark)

    Frandsen, Henrik

    found to be multiple organ carcinogens. The aminoimidazoazaarenes are metabolically activated by hydroxylation of the exocyclic aminogroup to the N-hydroxyamino derivative. The resultant proximate mutagens often need further activation by phase II transferases for formation of reactive species that form...

  6. Gorenstein derived functions

    DEFF Research Database (Denmark)

    Holm, Henrik Granau

    2004-01-01

    Over any associative ring R it is standard to derive HomR(􀀀;􀀀) using projective resolutions in the rst variable, or injective resolutions in the second variable, and doing this, one obtains Extn R(􀀀;􀀀) in both cases. We examine the situation where projective an...

  7. Petroleum-derived carbons

    Energy Technology Data Exchange (ETDEWEB)

    Bacha, J.D.; Newman, J.W.; White, J.L. (eds.)

    1986-01-01

    The 25 typescript papers in this volume derive from an ACS symposium held at an undisclosed site and date. They are concerned with such subjects as coke, carbon composites, the carbonization process, surface area, etc., and are accompanied by a 12-page index.

  8. Evolution strategies for robust optimization

    NARCIS (Netherlands)

    Kruisselbrink, Johannes Willem

    2012-01-01

    Real-world (black-box) optimization problems often involve various types of uncertainties and noise emerging in different parts of the optimization problem. When this is not accounted for, optimization may fail or may yield solutions that are optimal in the classical strict notion of optimality, but

  9. Optimization of photonic crystal cavities

    DEFF Research Database (Denmark)

    Wang, Fengwen; Sigmund, Ole

    2017-01-01

    We present optimization of photonic crystal cavities. The optimization problem is formulated to maximize the Purcell factor of a photonic crystal cavity. Both topology optimization and air-hole-based shape optimization are utilized for the design process. Numerical results demonstrate...... that the Purcell factor of the photonic crystal cavity can be significantly improved through optimization....

  10. Approximate *-derivations and approximate quadratic *-derivations on C*-algebras

    Directory of Open Access Journals (Sweden)

    Park Choonkil

    2011-01-01

    Full Text Available Abstract In this paper, we prove the stability of *-derivations and of quadratic *-derivations on Banach *-algebras. We moreover prove the superstability of *-derivations and of quadratic *-derivations on C*-algebras. 2000 Mathematics Subject Classification: 39B52; 47B47; 46L05; 39B72.

  11. Topology optimized microbioreactors.

    Science.gov (United States)

    Schäpper, Daniel; Lencastre Fernandes, Rita; Lantz, Anna Eliasson; Okkels, Fridolin; Bruus, Henrik; Gernaey, Krist V

    2011-04-01

    This article presents the fusion of two hitherto unrelated fields--microbioreactors and topology optimization. The basis for this study is a rectangular microbioreactor with homogeneously distributed immobilized brewers yeast cells (Saccharomyces cerevisiae) that produce a recombinant protein. Topology optimization is then used to change the spatial distribution of cells in the reactor in order to optimize for maximal product flow out of the reactor. This distribution accounts for potentially negative effects of, for example, by-product inhibition. We show that the theoretical improvement in productivity is at least fivefold compared with the homogeneous reactor. The improvements obtained by applying topology optimization are largest where either nutrition is scarce or inhibition effects are pronounced. Copyright © 2010 Wiley Periodicals, Inc.

  12. Dynamic stochastic optimization

    CERN Document Server

    Ermoliev, Yuri; Pflug, Georg

    2004-01-01

    Uncertainties and changes are pervasive characteristics of modern systems involving interactions between humans, economics, nature and technology. These systems are often too complex to allow for precise evaluations and, as a result, the lack of proper management (control) may create significant risks. In order to develop robust strategies we need approaches which explic­ itly deal with uncertainties, risks and changing conditions. One rather general approach is to characterize (explicitly or implicitly) uncertainties by objec­ tive or subjective probabilities (measures of confidence or belief). This leads us to stochastic optimization problems which can rarely be solved by using the standard deterministic optimization and optimal control methods. In the stochastic optimization the accent is on problems with a large number of deci­ sion and random variables, and consequently the focus ofattention is directed to efficient solution procedures rather than to (analytical) closed-form solu­ tions. Objective an...

  13. Handbook of simulation optimization

    CERN Document Server

    Fu, Michael C

    2014-01-01

    The Handbook of Simulation Optimization presents an overview of the state of the art of simulation optimization, providing a survey of the most well-established approaches for optimizing stochastic simulation models and a sampling of recent research advances in theory and methodology. Leading contributors cover such topics as discrete optimization via simulation, ranking and selection, efficient simulation budget allocation, random search methods, response surface methodology, stochastic gradient estimation, stochastic approximation, sample average approximation, stochastic constraints, variance reduction techniques, model-based stochastic search methods and Markov decision processes. This single volume should serve as a reference for those already in the field and as a means for those new to the field for understanding and applying the main approaches. The intended audience includes researchers, practitioners and graduate students in the business/engineering fields of operations research, management science,...

  14. Cooperative Bacterial Foraging Optimization

    Directory of Open Access Journals (Sweden)

    Hanning Chen

    2009-01-01

    Full Text Available Bacterial Foraging Optimization (BFO is a novel optimization algorithm based on the social foraging behavior of E. coli bacteria. This paper presents a variation on the original BFO algorithm, namely, the Cooperative Bacterial Foraging Optimization (CBFO, which significantly improve the original BFO in solving complex optimization problems. This significant improvement is achieved by applying two cooperative approaches to the original BFO, namely, the serial heterogeneous cooperation on the implicit space decomposition level and the serial heterogeneous cooperation on the hybrid space decomposition level. The experiments compare the performance of two CBFO variants with the original BFO, the standard PSO and a real-coded GA on four widely used benchmark functions. The new method shows a marked improvement in performance over the original BFO and appears to be comparable with the PSO and GA.

  15. Bolt Thread Stress Optimization

    DEFF Research Database (Denmark)

    Pedersen, Niels Leergaard

    2012-01-01

    Designs of threaded fasteners are controlled by different standards, and the number of different thread definitions is large. The most commonly used thread is probably the metric ISO thread, and this design is therefore used in this paper. Thread root design controls the stress concentration factor...... of threads and therefore indirectly the bolt fatigue life. The root shape is circular, and from shape optimization for minimum stress concentration it is well known that the circular shape is seldom optimal. An axisymmetric Finite Element (FE) formulation is used to analyze the bolted connection, and a study...... is performed to establish the need for contact modeling with regard to finding the correct stress concentration factor. Optimization is performed with a simple parameterization with two design variables. Stress reduction of up to 9% is found in the optimization process, and some similarities are found...

  16. Optimal mixture experiments

    CERN Document Server

    Sinha, B K; Pal, Manisha; Das, P

    2014-01-01

    The book dwells mainly on the optimality aspects of mixture designs. As mixture models are a special case of regression models, a general discussion on regression designs has been presented, which includes topics like continuous designs, de la Garza phenomenon, Loewner order domination, Equivalence theorems for different optimality criteria and standard optimality results for single variable polynomial regression and multivariate linear and quadratic regression models. This is followed by a review of the available literature on estimation of parameters in mixture models. Based on recent research findings, the volume also introduces optimal mixture designs for estimation of optimum mixing proportions in different mixture models, which include Scheffé’s quadratic model, Darroch-Waller model, log- contrast model, mixture-amount models, random coefficient models and multi-response model.  Robust mixture designs and mixture designs in blocks have been also reviewed. Moreover, some applications of mixture desig...

  17. Stochastic optimization methods

    CERN Document Server

    Marti, Kurt

    2005-01-01

    Optimization problems arising in practice involve random parameters. For the computation of robust optimal solutions, i.e., optimal solutions being insensitive with respect to random parameter variations, deterministic substitute problems are needed. Based on the distribution of the random data, and using decision theoretical concepts, optimization problems under stochastic uncertainty are converted into deterministic substitute problems. Due to the occurring probabilities and expectations, approximative solution techniques must be applied. Deterministic and stochastic approximation methods and their analytical properties are provided: Taylor expansion, regression and response surface methods, probability inequalities, First Order Reliability Methods, convex approximation/deterministic descent directions/efficient points, stochastic approximation methods, differentiation of probability and mean value functions. Convergence results of the resulting iterative solution procedures are given.

  18. Optimization in liner shipping

    DEFF Research Database (Denmark)

    Brouer, Berit Dangaard; Karsten, Christian Vad; Pisinger, David

    2017-01-01

    Seaborne trade is the lynchpin in almost every international supply chain, and about 90% of non-bulk cargo worldwide is transported by container. In this survey we give an overview of data-driven optimization problems in liner shipping. Research in liner shipping is motivated by a need for handling...... shipping network design, we consider the problem of container routing and speed optimization. Next, we consider empty container repositioning and stowage planning as well as disruption management. In addition, the problem of bunker purchasing is considered in depth. In each section we give a clear problem...... still more complex decision problems, based on big data sets and going across several organizational entities. Moreover, liner shipping optimization problems are pushing the limits of optimization methods, creating a new breeding ground for advanced modelling and solution methods. Starting from liner...

  19. ON THE DERIVATIVE OF SMOOTH MEANINGFUL FUNCTIONS

    Directory of Open Access Journals (Sweden)

    Sanjo Zlobec

    2011-02-01

    Full Text Available The derivative of a function f in n variables at a point x* is one of the most important tools in mathematical modelling. If this object exists, it is represented by the row n-tuple f(x* = [∂f/∂xi(x*] called the gradient of f at x*, abbreviated: “the gradient”. The evaluation of f(x* is usually done in two stages, first by calculating the n partials and then their values at x = x*. In this talk we give an alternative approach. We show that one can characterize the gradient without differentiation! The idea is to fix an arbitrary row n-tuple G and answer the following question: What is a necessary and sufficient condition such that G is the gradient of a given f at a given x*? The answer is given after adjusting the quadratic envelope property introduced in [3]. We work with smooth, i.e., continuously differentiable, functions with a Lipschitz derivative on a compact convex set with a non-empty interior. Working with this class of functions is not a serious restriction. In fact, loosely speaking, “almost all” smooth meaningful functions used in modelling of real life situations are expected to have a bounded “acceleration” hence they belong to this class. In particular, the class contains all twice differentiable functions [1]. An important property of the functions from this class is that every f can be represented as the difference of some convex function and a convex quadratic function. This decomposition was used in [3] to characterize the zero derivative points. There we obtained reformulations and augmentations of some well known classic results on optimality such as Fermats extreme value theorem (known from high school and the Lagrange multiplier theorem from calculus [2, 3]. In this talk we extend the results on zero derivative points to characterize the relation G = f(x*, where G is an arbitrary n-tuple. Some special cases: If G = O, we recover the results on zero derivative points. For functions of a single

  20. Optimization Library for Interactive Multi-Criteria Optimization Tasks

    OpenAIRE

    Pfeiffer, Andreas

    2012-01-01

    The commercial library Optimization 2.1 for interactive multi-criteria optimization tasks has been released along with Dymola 2013. The library offers several numerical optimization algorithms for solving different kinds of optimization tasks. User defined Modelica functions or models provide the basis for an interactive optimization process where the user keeps overview of complex multi-criteria optimization tasks that can take discrete parameters, several model operating points or trajector...

  1. Deterministic global optimization an introduction to the diagonal approach

    CERN Document Server

    Sergeyev, Yaroslav D

    2017-01-01

    This book begins with a concentrated introduction into deterministic global optimization and moves forward to present new original results from the authors who are well known experts in the field. Multiextremal continuous problems that have an unknown structure with Lipschitz objective functions and functions having the first Lipschitz derivatives defined over hyperintervals are examined. A class of algorithms using several Lipschitz constants is introduced which has its origins in the DIRECT (DIviding RECTangles) method. This new class is based on an efficient strategy that is applied for the search domain partitioning. In addition a survey on derivative free methods and methods using the first derivatives is given for both one-dimensional and multi-dimensional cases. Non-smooth and smooth minorants and acceleration techniques that can speed up several classes of global optimization methods with examples of applications and problems arising in numerical testing of global optimization algorithms are discussed...

  2. Optimal Responsible Investment

    DEFF Research Database (Denmark)

    Jessen, Pernille

    The paper studies retail Socially Responsible Investment and portfolio allocation. It extends conventional portfolio theory by allowing for a personal value based investment decision. When preferences for responsibility enter the framework for mean-variance analysis, it yields an optimal...... responsible investment model. An example of index investing illustrates the theory. Results show that it is crucial for the responsible investor to consider portfolio risk, expected return, and responsibility simultaneously in order to obtain an optimal portfolio. The model enables responsible investors...

  3. Optimization of Bolt Stress

    DEFF Research Database (Denmark)

    Pedersen, Niels Leergaard

    2013-01-01

    The state of stress in bolts and nuts with ISO metric thread design is examined and optimized. The assumed failure mode is fatigue so the applied preload and the load amplitude together with the stress concentrations define the connection strength. Maximum stress in the bolt is found at, the fillet...... under the head, at the thread start or at the thread root. To minimize the stress concentration shape optimization is applied....

  4. Pareto-optimal alloys

    DEFF Research Database (Denmark)

    Bligaard, Thomas; Johannesson, Gisli Holmar; Ruban, Andrei

    2003-01-01

    and the cost. In this letter we present a database consisting of the lattice parameters, bulk moduli, and heats of formation for over 64 000 ordered metallic alloys, which has been established by direct first-principles density-functional-theory calculations. Furthermore, we use a concept from economic theory......, the Pareto-optimal set, to determine optimal alloy solutions for the compromise between low compressibility, high stability, and cost....

  5. Testing unconstrained optimization software

    Energy Technology Data Exchange (ETDEWEB)

    More, J.J.; Garbow, B.S.; Hillstrom, K.E.

    1978-07-01

    Much of the testing of optimization software is inadequate because the number of test functions is small or the starting points are close to the solution. In addition, there has been too much emphasis on measuring the efficiency of the software and not enough on testing reliability and robustness. To address this need, a relatively large but easy-to-use collection of test functions was produced and guidelines for testing the reliability and robustness of unconstrained optimization software were designed. 9 tables.

  6. Topology optimized microbioreactors

    DEFF Research Database (Denmark)

    Schäpper, Daniel; Lencastre Fernandes, Rita; Eliasson Lantz, Anna

    2011-01-01

    This article presents the fusion of two hitherto unrelated fields—microbioreactors and topology optimization. The basis for this study is a rectangular microbioreactor with homogeneously distributed immobilized brewers yeast cells (Saccharomyces cerevisiae) that produce a recombinant protein...... in productivity is at least fivefold compared with the homogeneous reactor. The improvements obtained by applying topology optimization are largest where either nutrition is scarce or inhibition effects are pronounced....

  7. Optimal Stochastic Advertising Strategies for the U.S. Beef Industry

    OpenAIRE

    Kun C. Lee; Stanley Schraufnagel; Earl O. Heady

    1982-01-01

    An important decision variable in the promotional strategy for the beef sector is the optimal level of advertising expenditures over time. Optimal stochastic and deterministic advertising expenditures are derived for the U.S. beef industry for the period `1966 through 1980. They are compared with historical levels and gains realized by optimal advertising strategies are measured. Finally, the optimal advertising expenditures in the future are forecasted.

  8. Design and regularization of neural networks: the optimal use of a validation set

    DEFF Research Database (Denmark)

    Larsen, Jan; Hansen, Lars Kai; Svarer, Claus

    1996-01-01

    We derive novel algorithms for estimation of regularization parameters and for optimization of neural net architectures based on a validation set. Regularisation parameters are estimated using an iterative gradient descent scheme. Architecture optimization is performed by approximative...... combinatorial search among the relevant subsets of an initial neural network architecture by employing a validation set based optimal brain damage/surgeon (OBD/OBS) or a mean field combinatorial optimization approach. Numerical results with linear models and feed-forward neural networks demonstrate...

  9. 5th Optimization Day

    CERN Document Server

    Mees, Alistair; Fisher, Mike; Jennings, Les

    2000-01-01

    'Optimization Day' (OD) has been a series of annual mini-conferences in Australia since 1994. The purpose of this series of events is to gather researchers in optimization and its related areas from Australia and their collaborators, in order to exchange new developments of optimization theories, methods and their applications. The first four OD mini-conferences were held in The Uni­ versity of Ballarat (1994), The University of New South Wales (1995), The University of Melbourne (1996) and Royal Melbourne Institute of Technology (1997), respectively. They were all on the eastern coast of Australia. The fifth mini-conference Optimization Days was held at the Centre for Ap­ plied Dynamics and Optimization (CADO), Department of Mathematics and Statistics, The University of Western Australia, Perth, from 29 to 30 June 1998. This is the first time the OD mini-conference has been held at the west­ ern coast of Australia. This fifth OD preceded the International Conference on Optimization: Techniques and Applica...

  10. Adaptive Bacterial Foraging Optimization

    Directory of Open Access Journals (Sweden)

    Hanning Chen

    2011-01-01

    Full Text Available Bacterial Foraging Optimization (BFO is a recently developed nature-inspired optimization algorithm, which is based on the foraging behavior of E. coli bacteria. Up to now, BFO has been applied successfully to some engineering problems due to its simplicity and ease of implementation. However, BFO possesses a poor convergence behavior over complex optimization problems as compared to other nature-inspired optimization techniques. This paper first analyzes how the run-length unit parameter of BFO controls the exploration of the whole search space and the exploitation of the promising areas. Then it presents a variation on the original BFO, called the adaptive bacterial foraging optimization (ABFO, employing the adaptive foraging strategies to improve the performance of the original BFO. This improvement is achieved by enabling the bacterial foraging algorithm to adjust the run-length unit parameter dynamically during algorithm execution in order to balance the exploration/exploitation tradeoff. The experiments compare the performance of two versions of ABFO with the original BFO, the standard particle swarm optimization (PSO and a real-coded genetic algorithm (GA on four widely-used benchmark functions. The proposed ABFO shows a marked improvement in performance over the original BFO and appears to be comparable with the PSO and GA.

  11. Totally optimal decision rules

    KAUST Repository

    Amin, Talha

    2017-11-22

    Optimality of decision rules (patterns) can be measured in many ways. One of these is referred to as length. Length signifies the number of terms in a decision rule and is optimally minimized. Another, coverage represents the width of a rule’s applicability and generality. As such, it is desirable to maximize coverage. A totally optimal decision rule is a decision rule that has the minimum possible length and the maximum possible coverage. This paper presents a method for determining the presence of totally optimal decision rules for “complete” decision tables (representations of total functions in which different variables can have domains of differing values). Depending on the cardinalities of the domains, we can either guarantee for each tuple of values of the function that totally optimal rules exist for each row of the table (as in the case of total Boolean functions where the cardinalities are equal to 2) or, for each row, we can find a tuple of values of the function for which totally optimal rules do not exist for this row.

  12. Optimization and anti-optimization of structures under uncertainty

    National Research Council Canada - National Science Library

    Elishakoff, Isaac; Ohsaki, Makoto

    2010-01-01

    The volume presents a collaboration between internationally recognized experts on anti-optimization and structural optimization, and summarizes various novel ideas, methodologies and results studied over 20 years...

  13. On Conditions for Linearity of Optimal Estimation

    CERN Document Server

    Akyol, Emrah; Rose, Kenneth

    2011-01-01

    When is optimal estimation linear? It is well known that, when a Gaussian source is contaminated with Gaussian noise, a linear estimator minimizes the mean square estimation error. This paper analyzes, more generally, the conditions for linearity of optimal estimators. Given a noise (or source) distribution, and a specified signal to noise ratio (SNR), we derive conditions for existence and uniqueness of a source (or noise) distribution for which the $L_p$ optimal estimator is linear. We then show that, if the noise and source variances are equal, then the matching source must be distributed identically to the noise. Moreover, we prove that the Gaussian source-channel pair is unique in the sense that it is the only source-channel pair for which the mean square error (MSE) optimal estimator is linear at more than one SNR values. Further, we show the asymptotic linearity of MSE optimal estimators for low SNR if the channel is Gaussian regardless of the source and, vice versa, for high SNR if the source is Gauss...

  14. Rapid near-optimal aerospace plane trajectory generation and guidance

    Science.gov (United States)

    Corban, J. E.; Calise, A. J.; Flandro, G. A.

    1991-01-01

    Problems associated with onboard trajectory optimization, propulsion system cycle selection, and the synthesis of guidance laws are addressed for ascent to low earth orbit of an airbreathing, single-stage-to-orbit vehicle. A multicycle propulsion system is assumed that incorporates turbojet, ramjet, scramjet, and rocket engines. An energy state approximation is applied to a singularly perturbed, four-state dynamic model for flight of a point mass over a spherical nonrotating earth. An algorithm is then derived for generating both the fuel-optimal climb profile and the guidance commands required to follow that profile. In particular, analytic switching conditions are derived that, under appropriate assumptions, efficiently govern optimal transition from one propulsion cycle to another. The algorithm proves to be computationally efficient and suitable for real-time implementation. The paper concludes with the presentation of representative numerical results that illustrate the nature of the fuel-optimal climb paths and the tracking performance of the guidance algorithm.

  15. RELATIVE CAMERA POSE ESTIMATION METHOD USING OPTIMIZATION ON THE MANIFOLD

    Directory of Open Access Journals (Sweden)

    C. Cheng

    2017-05-01

    Full Text Available To solve the problem of relative camera pose estimation, a method using optimization with respect to the manifold is proposed. Firstly from maximum-a-posteriori (MAP model to nonlinear least squares (NLS model, the general state estimation model using optimization is derived. Then the camera pose estimation model is applied to the general state estimation model, while the parameterization of rigid body transformation is represented by Lie group/algebra. The jacobian of point-pose model with respect to Lie group/algebra is derived in detail and thus the optimization model of rigid body transformation is established. Experimental results show that compared with the original algorithms, the approaches with optimization can obtain higher accuracy both in rotation and translation, while avoiding the singularity of Euler angle parameterization of rotation. Thus the proposed method can estimate relative camera pose with high accuracy and robustness.

  16. Galerkin approximations of nonlinear optimal control problems in Hilbert spaces

    Directory of Open Access Journals (Sweden)

    Mickael D. Chekroun

    2017-07-01

    Full Text Available Nonlinear optimal control problems in Hilbert spaces are considered for which we derive approximation theorems for Galerkin approximations. Approximation theorems are available in the literature. The originality of our approach relies on the identification of a set of natural assumptions that allows us to deal with a broad class of nonlinear evolution equations and cost functionals for which we derive convergence of the value functions associated with the optimal control problem of the Galerkin approximations. This convergence result holds for a broad class of nonlinear control strategies as well. In particular, we show that the framework applies to the optimal control of semilinear heat equations posed on a general compact manifold without boundary. The framework is then shown to apply to geoengineering and mitigation of greenhouse gas emissions formulated here in terms of optimal control of energy balance climate models posed on the sphere $\\mathbb{S}^2$.

  17. Handbook of optimization in telecommunications

    CERN Document Server

    Pardalos, Panos M

    2008-01-01

    Covers the field of optimization in telecommunications, and the optimization developments that are frequently applied to telecommunications. This book aims to provide a reference tool for scientists and engineers in telecommunications who depend upon optimization.

  18. On Symmetries in Optimal Control

    NARCIS (Netherlands)

    Schaft, A.J. van der

    1986-01-01

    We discuss the use of symmetries in solving optimal control problems. In particular a procedure for obtaining symmetries is given which can be performed before the actual calculation of the optimal control and optimal Hamiltonian.

  19. Quinazolin-4-one derivatives

    DEFF Research Database (Denmark)

    Mosley, Cara A; Acker, Timothy M; Hansen, Kasper Bø

    2010-01-01

    We describe a new class of subunit-selective antagonists of N-methyl D-aspartate (NMDA)-selective ionotropic glutamate receptors that contain the (E)-3-phenyl-2-styrylquinazolin-4(3H)-one backbone. The inhibition of recombinant NMDA receptor function induced by these quinazolin-4-one derivatives ...... were identified with 50-fold selectivity for recombinant NR2C/D-containing receptors over NR2A/B containing receptors. These compounds represent a new class of noncompetitive subunit-selective NMDA receptor antagonists.......We describe a new class of subunit-selective antagonists of N-methyl D-aspartate (NMDA)-selective ionotropic glutamate receptors that contain the (E)-3-phenyl-2-styrylquinazolin-4(3H)-one backbone. The inhibition of recombinant NMDA receptor function induced by these quinazolin-4-one derivatives...

  20. 4-Aminoquinoline derivatives

    DEFF Research Database (Denmark)

    Singh, Shailja; Agarwal, Drishti; Sharma, Kumkum

    2016-01-01

    Synthetic quinoline derivatives continue to be considered as candidates for new drug discovery if they act against CQ-resistant strains of malaria even after the widespread emergence of resistance to CQ. In this study, we explored the activities of two series of new 4-aminoquinoline derivatives....... The ED50 values were calculated to be 2.062, 2.231, 1.431, 1.623 and 1.18 mg/kg of body weight for each of the compounds 1m, 1o, 2c, 2j and amodiaquine, respectively. Total doses of 500 mg/kg of body weight were well received. The study suggests that these new 4-aminoquinolines should be used...

  1. Essays on Derivatives Pricing

    DEFF Research Database (Denmark)

    Kokholm, Thomas

    The field of quantitative finance has been criticized in the mainstream media lately and been accused of being one of the causes of the financial crisis. Convenient as this explanation may be, my belief is that a part of the solution to the crisis is to use more (and not less) sophisticated...... financial models, and most importantly, to be aware of their limitations. Following that belief, this thesis consists of three independent and self-contained papers, all dealing with topics in derivatives pricing. The first paper considers the pricing of traffic light options, which are appropriate...... the market for multivariate credit instruments, we take a step back and focus on single-name default modeling and introduce two new model classes for modeling of the default time of a company. Finally, in the third paper we propose a consistent pricing model for index and volatility derivatives...

  2. Conceptual design and optimization methodology for box wing aircraft

    OpenAIRE

    Jemitola, Paul Olugbeji

    2012-01-01

    A conceptual design optimization methodology was developed for a medium range box wing aircraft. A baseline conventional cantilever wing aircraft designed for the same mis- sion and payload was also optimized alongside a baseline box wing aircraft. An empirical formula for the mass estimation of the fore and aft wings of the box wing aircraft was derived by relating conventional cantilever wings to box wing aircraft wings. The results indicate that the fore and aft wings would ...

  3. Enabling quaternion derivatives: the generalized HR calculus

    Science.gov (United States)

    Xu, Dongpo; Jahanchahi, Cyrus; Took, Clive C.; Mandic, Danilo P.

    2015-01-01

    Quaternion derivatives exist only for a very restricted class of analytic (regular) functions; however, in many applications, functions of interest are real-valued and hence not analytic, a typical case being the standard real mean square error objective function. The recent HR calculus is a step forward and provides a way to calculate derivatives and gradients of both analytic and non-analytic functions of quaternion variables; however, the HR calculus can become cumbersome in complex optimization problems due to the lack of rigorous product and chain rules, a consequence of the non-commutativity of quaternion algebra. To address this issue, we introduce the generalized HR (GHR) derivatives which employ quaternion rotations in a general orthogonal system and provide the left- and right-hand versions of the quaternion derivative of general functions. The GHR calculus also solves the long-standing problems of product and chain rules, mean-value theorem and Taylor's theorem in the quaternion field. At the core of the proposed GHR calculus is quaternion rotation, which makes it possible to extend the principle to other functional calculi in non-commutative settings. Examples in statistical learning theory and adaptive signal processing support the analysis. PMID:26361555

  4. Enabling quaternion derivatives: the generalized HR calculus.

    Science.gov (United States)

    Xu, Dongpo; Jahanchahi, Cyrus; Took, Clive C; Mandic, Danilo P

    2015-08-01

    Quaternion derivatives exist only for a very restricted class of analytic (regular) functions; however, in many applications, functions of interest are real-valued and hence not analytic, a typical case being the standard real mean square error objective function. The recent HR calculus is a step forward and provides a way to calculate derivatives and gradients of both analytic and non-analytic functions of quaternion variables; however, the HR calculus can become cumbersome in complex optimization problems due to the lack of rigorous product and chain rules, a consequence of the non-commutativity of quaternion algebra. To address this issue, we introduce the generalized HR (GHR) derivatives which employ quaternion rotations in a general orthogonal system and provide the left- and right-hand versions of the quaternion derivative of general functions. The GHR calculus also solves the long-standing problems of product and chain rules, mean-value theorem and Taylor's theorem in the quaternion field. At the core of the proposed GHR calculus is quaternion rotation, which makes it possible to extend the principle to other functional calculi in non-commutative settings. Examples in statistical learning theory and adaptive signal processing support the analysis.

  5. Revisiting optimal eavesdropping in quantum cryptography: Optimal interaction is unique up to rotation of the underlying basis

    Science.gov (United States)

    Acharyya, Atanu; Paul, Goutam

    2017-02-01

    A general framework of optimal eavesdropping on BB84 protocol was provided by Fuchs et al. [Phys. Rev. A 56, 1163 (1997), 10.1103/PhysRevA.56.1163]. An upper bound on mutual information was derived, which could be achieved by a specific type of interaction and the corresponding measurement. However, uniqueness of optimal interaction was posed as an unsolved problem there and it has remained open for almost two decades now. In this paper, we solve this open problem and establish the uniqueness of optimal interaction up to rotation. The specific choice of optimal interaction by Fuchs et al. is shown to be a special case of the form derived in our work.

  6. Multifunctional Cinnamic Acid Derivatives

    Directory of Open Access Journals (Sweden)

    Aikaterini Peperidou

    2017-07-01

    Full Text Available Our research to discover potential new multitarget agents led to the synthesis of 10 novel derivatives of cinnamic acids and propranolol, atenolol, 1-adamantanol, naphth-1-ol, and (benzylamino ethan-1-ol. The synthesized molecules were evaluated as trypsin, lipoxygenase and lipid peroxidation inhibitors and for their cytotoxicity. Compound 2b derived from phenoxyphenyl cinnamic acid and propranolol showed the highest lipoxygenase (LOX inhibition (IC50 = 6 μΜ and antiproteolytic activity (IC50 = 0.425 μΜ. The conjugate 1a of simple cinnamic acid with propranolol showed the higher antiproteolytic activity (IC50 = 0.315 μΜ and good LOX inhibitory activity (IC50 = 66 μΜ. Compounds 3a and 3b, derived from methoxylated caffeic acid present a promising combination of in vitro inhibitory and antioxidative activities. The S isomer of 2b also presented an interesting multitarget biological profile in vitro. Molecular docking studies point to the fact that the theoretical results for LOX-inhibitor binding are identical to those from preliminary in vitro study.

  7. A Thermodynamic Library for Simulation and Optimization of Dynamic Processes

    DEFF Research Database (Denmark)

    Ritschel, Tobias Kasper Skovborg; Gaspar, Jozsef; Jørgensen, John Bagterp

    2017-01-01

    compounds and mixtures. However, rigorous thermodynamic models are generally computationally intensive and not available as open-source libraries for process simulation and optimization. In this paper, we describe the application of a novel open-source rigorous thermodynamic library, ThermoLib, which....... These derivatives are needed for efficient dynamic simulation and optimization. The analytical derivatives improve the computational performance by a factor between 12 and 35 as compared to finite difference approximations. We present two examples that use ThermoLib routines in their implementations: (1) simulation...

  8. Qualitative Analysis of Plant-Derived Samples by Liquid ...

    African Journals Online (AJOL)

    Purpose: Currently, mass spectrometry has become an effective method for the qualitative analysis of plant-derived samples. Precursor and product ions can be obtained by tandem mass spectrometry, supplying rich information for determining the structural formulas of compounds. In this work, we review the optimization of ...

  9. Shape and Structural Optimization of Flapping Wings

    Science.gov (United States)

    Stewart, Eric Colby

    This dissertation presents shape and structural optimization studies on flapping wings for micro air vehicles. The design space of the optimization includes the wing planform and the structural properties that are relevant to the wing model being analyzed. The planform design is parameterized using a novel technique called modified Zimmerman, which extends the concept of Zimmerman planforms to include four ellipses rather than two. Three wing types are considered: rigid, plate-like deformable, and membrane. The rigid wing requires no structural design variables. The structural design variables for the plate-like wing are the thickness distribution polynomial coefficients. The structural variables for the membrane wing control the in-plane distributed forces which modulate the structural deformation of the wing. The rigid wing optimization is performed using the modified Zimmerman method to describe the wing. A quasi-steady aerodynamics model is used to calculate the thrust and input power required during the flapping cycle. An assumed inflow model is derived based on lifting-line theory and is used to better approximate the effects of the induced drag on the wing. A multi-objective optimization approach is used since more than one aspect is considered in flapping wing design. The the epsilon-constraint approach is used to calculate the Pareto optimal solutions that maximize the cycle-average thrust while minimizing the peak input power and the wing mass. An aeroelastic model is derived to calculate the aerodynamic performance and the structural response of the deformable wings. A linearized unsteady vortex lattice method is tightly coupled to a linear finite element model. The model is cost effective and the steady-state solution is solved by inverting a matrix. The aeroelastic model is used to maximize the thrust produced over one flapping cycle while minimizing the input power.

  10. Credit derivatives and risk management

    OpenAIRE

    Gibson, Michael S.

    2007-01-01

    The striking growth of credit derivatives suggests that market participants find them to be useful tools for risk management. I illustrate the value of credit derivatives with three examples. A commercial bank can use credit derivatives to manage the risk of its loan portfolio. An investment bank can use credit derivatives to manage the risks it incurs when underwriting securities. An investor, such as an insurance company, asset manager, or hedge fund, can use credit derivatives to align its...

  11. Optimization of Heat Exchangers

    Energy Technology Data Exchange (ETDEWEB)

    Ivan Catton

    2010-10-01

    The objective of this research is to develop tools to design and optimize heat exchangers (HE) and compact heat exchangers (CHE) for intermediate loop heat transport systems found in the very high temperature reator (VHTR) and other Generation IV designs by addressing heat transfer surface augmentation and conjugate modeling. To optimize heat exchanger, a fast running model must be created that will allow for multiple designs to be compared quickly. To model a heat exchanger, volume averaging theory, VAT, is used. VAT allows for the conservation of mass, momentum and energy to be solved for point by point in a 3 dimensional computer model of a heat exchanger. The end product of this project is a computer code that can predict an optimal configuration for a heat exchanger given only a few constraints (input fluids, size, cost, etc.). As VAT computer code can be used to model characteristics )pumping power, temperatures, and cost) of heat exchangers more quickly than traditional CFD or experiment, optimization of every geometric parameter simultaneously can be made. Using design of experiment, DOE and genetric algorithms, GE, to optimize the results of the computer code will improve heat exchanger disign.

  12. Optimization of Metronidazole Emulgel

    Directory of Open Access Journals (Sweden)

    Monica Rao

    2013-01-01

    Full Text Available The purpose of the present study was to develop and optimize the emulgel system for MTZ (Metronidazole, a poorly water soluble drug. The pseudoternary phase diagrams were developed for various microemulsion formulations composed of Capmul 908 P, Acconon MC8-2, and propylene glycol. The emulgel was optimized using a three-factor, two-level factorial design, the independent variables selected were Capmul 908 P, and surfactant mixture (Acconon MC8-2 and gelling agent, and the dependent variables (responses were a cumulative amount of drug permeated across the dialysis membrane in 24 h ( and spreadability (. Mathematical equations and response surface plots were used to relate the dependent and independent variables. The regression equations were generated for responses and . The statistical validity of the polynomials was established, and optimized formulation factors were selected. Validation of the optimization study with 3 confirmatory runs indicated a high degree of prognostic ability of response surface methodology. Emulgel system of MTZ was developed and optimized using 23 factorial design and could provide an effective treatment against topical infections.

  13. Polymer Derived Yttrium Silicate Ablative TPS Materials for Next-Generation Exploration Missions Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Through the proposed NASA SBIR program, NanoSonic will optimize its HybridSil® derived yttrium silicates to serve as next-generation reinforcement for carbon...

  14. Synthesis of new N-arylpyrimidin-2-amine derivatives using a palladium catalyst

    National Research Council Canada - National Science Library

    El-Deeb, Ibrahim Mustafa; Ryu, Jae Chun; Lee, So Ha

    2008-01-01

    New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesized from the corresponding amines, applying optimized Buchwald-Hartwig amination conditions using dichlorobis(triphenylphosphine)Pd(II...

  15. Regression analysis as a design optimization tool

    Science.gov (United States)

    Perley, R.

    1984-01-01

    The optimization concepts are described in relation to an overall design process as opposed to a detailed, part-design process where the requirements are firmly stated, the optimization criteria are well established, and a design is known to be feasible. The overall design process starts with the stated requirements. Some of the design criteria are derived directly from the requirements, but others are affected by the design concept. It is these design criteria that define the performance index, or objective function, that is to be minimized within some constraints. In general, there will be multiple objectives, some mutually exclusive, with no clear statement of their relative importance. The optimization loop that is given adjusts the design variables and analyzes the resulting design, in an iterative fashion, until the objective function is minimized within the constraints. This provides a solution, but it is only the beginning. In effect, the problem definition evolves as information is derived from the results. It becomes a learning process as we determine what the physics of the system can deliver in relation to the desirable system characteristics. As with any learning process, an interactive capability is a real attriubute for investigating the many alternatives that will be suggested as learning progresses.

  16. Optimizing rotary processes in synthetic molecular motors

    Science.gov (United States)

    Geertsema, Edzard M.; van der Molen, Sense Jan; Martens, Marco; Feringa, Ben L.

    2009-01-01

    We deal with the issue of quantifying and optimizing the rotation dynamics of synthetic molecular motors. For this purpose, the continuous four-stage rotation behavior of a typical light-activated molecular motor was measured in detail. All reaction constants were determined empirically. Next, we developed a Markov model that describes the full motor dynamics mathematically. We derived expressions for a set of characteristic quantities, i.e., the average rate of quarter rotations or “velocity,” V, the spread in the average number of quarter rotations, D, and the dimensionless Péclet number, Pe = V/D. Furthermore, we determined the rate of full, four-step rotations (Ωeff), from which we derived another dimensionless quantity, the “rotational excess,” r.e. This quantity, defined as the relative difference between total forward (Ω+) and backward (Ω−) full rotations, is a good measure of the unidirectionality of the rotation process. Our model provides a pragmatic tool to optimize motor performance. We demonstrate this by calculating V, D, Pe, Ωeff, and r.e. for different rates of thermal versus photochemical energy input. We find that for a given light intensity, an optimal temperature range exists in which the motor exhibits excellent efficiency and unidirectional behavior, above or below which motor performance decreases. PMID:19805100

  17. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    2010-01-01

    This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...... health investments. At the same time, physiological aspects of the aging process inuence optimal savings and health investment. We calibrate the model for the average US male in 2000 and proceed to show that the calibrated model accounts well for the cross-country link between labor productivity and life...... expectancy in the same year ("the Preston curve"); cross-country income differences can explain differences in life expectancy at age 20 of up to a decade. Moreover, technological change in health care of about 1.1% per year can account for the observed shift in the Preston curve between 1980 and 2000....

  18. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    2010-01-01

    This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...... health investments. At the same time, physiological aspects of the aging process influence optimal savings and health investment. We calibrate the model for the average US male in 2000 and proceed to show that the calibrated model accounts well for the cross-country link between labor productivity...... and life expectancy in the same year ("the Preston curve"); cross-country income differences can explain differences in life expectancy at age 20 of up to a decade. Moreover, technological change in health care of about 1.1% per year can account for the observed shift in the Preston curve between 1980...

  19. First course in optimization

    CERN Document Server

    Byrne, Charles L

    2014-01-01

    Optimization without Calculus Chapter Summary The Arithmetic Mean-Geometric Mean Inequality An Application of the AGM Inequality: the Number e Extending the AGM Inequality Optimization Using the AGM Inequality The Holder and Minkowski Inequalities Cauchy's Inequality Optimizing using Cauchy's Inequality An Inner Product for Square Matrices Discrete Allocation Problems Geometric Programming Chapter Summary An Example of a GP Problem Posynomials and the GP Problem The Dual GP Problem Solving the GP Problem Solving the DGP Problem Constrained Geometric Programming Basic Analysis Chapter Summary Minima and Infima Limits Completeness Continuity Limsup and Liminf Another View Semi-Continuity Convex Sets Chapter SummaryThe Geometry of Real Euclidean Space A Bit of Topology Convex Sets in RJ More on Projections Linear and Affine Operators on RJ The Fundamental Theorems Block-Matrix Notation Theorems of the Alternative Another Proof of Farkas' Lemma Gordan's Theorem Revisited Vector Spaces and Matrices Chapter Summary...

  20. Optimized packings with applications

    CERN Document Server

    Pintér, János

    2015-01-01

    This volume presents a selection of case studies that address a substantial range of optimized object packings (OOP) and their applications. The contributing authors are well-recognized researchers and practitioners. The mathematical modelling and numerical solution aspects of each application case study are presented in sufficient detail. A broad range of OOP problems are discussed: these include various specific and non-standard container loading and object packing problems, as well as the stowing of hazardous and other materials on container ships, data centre resource management, automotive engineering design, space station logistic support, cutting and packing problems with placement constraints, the optimal design of LED street lighting, robust sensor deployment strategies, spatial scheduling problems, and graph coloring models and metaheuristics for packing applications. Novel points of view related to model development and to computational nonlinear, global, mixed integer optimization and heuristic st...

  1. Fuzzy logic controller optimization

    Science.gov (United States)

    Sepe, Jr., Raymond B; Miller, John Michael

    2004-03-23

    A method is provided for optimizing a rotating induction machine system fuzzy logic controller. The fuzzy logic controller has at least one input and at least one output. Each input accepts a machine system operating parameter. Each output produces at least one machine system control parameter. The fuzzy logic controller generates each output based on at least one input and on fuzzy logic decision parameters. Optimization begins by obtaining a set of data relating each control parameter to at least one operating parameter for each machine operating region. A model is constructed for each machine operating region based on the machine operating region data obtained. The fuzzy logic controller is simulated with at least one created model in a feedback loop from a fuzzy logic output to a fuzzy logic input. Fuzzy logic decision parameters are optimized based on the simulation.

  2. Reverse Osmosis Optimization

    Energy Technology Data Exchange (ETDEWEB)

    McMordie Stoughton, Kate; Duan, Xiaoli; Wendel, Emily M.

    2013-08-26

    This technology evaluation was prepared by Pacific Northwest National Laboratory on behalf of the U.S. Department of Energy’s Federal Energy Management Program (FEMP). ¬The technology evaluation assesses techniques for optimizing reverse osmosis (RO) systems to increase RO system performance and water efficiency. This evaluation provides a general description of RO systems, the influence of RO systems on water use, and key areas where RO systems can be optimized to reduce water and energy consumption. The evaluation is intended to help facility managers at Federal sites understand the basic concepts of the RO process and system optimization options, enabling them to make informed decisions during the system design process for either new projects or recommissioning of existing equipment. This evaluation is focused on commercial-sized RO systems generally treating more than 80 gallons per hour.¬

  3. Reverse Osmosis Optimization

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-08-01

    This technology evaluation was prepared by Pacific Northwest National Laboratory on behalf of the U.S. Department of Energy’s Federal Energy Management Program (FEMP). The technology evaluation assesses techniques for optimizing reverse osmosis (RO) systems to increase RO system performance and water efficiency. This evaluation provides a general description of RO systems, the influence of RO systems on water use, and key areas where RO systems can be optimized to reduce water and energy consumption. The evaluation is intended to help facility managers at Federal sites understand the basic concepts of the RO process and system optimization options, enabling them to make informed decisions during the system design process for either new projects or recommissioning of existing equipment. This evaluation is focused on commercial-sized RO systems generally treating more than 80 gallons per hour.

  4. Manufacturing tolerant topology optimization

    DEFF Research Database (Denmark)

    Sigmund, Ole

    2009-01-01

    In this paper we present an extension of the topology optimization method to include uncertainties during the fabrication of macro, micro and nano structures. More specifically, we consider devices that are manufactured using processes which may result in (uniformly) too thin (eroded) or too thick...... (dilated) structures compared to the intended topology. Examples are MEMS devices manufactured using etching processes, nano-devices manufactured using e-beam lithography or laser micro-machining and macro structures manufactured using milling processes. In the suggested robust topology optimization...... that the method provides manufacturing tolerant designs with little decrease in performance. As a positive side effect the robust design formulation also eliminates the longstanding problem of one-node connected hinges in compliant mechanism design using topology optimization....

  5. Optimizing turning for locomotion

    Science.gov (United States)

    Burton, Lisa; Hatton, Ross; Choset, Howie; Hosoi, A. E.

    2012-02-01

    Speed and efficiency are common and often adequate metrics to compare locomoting systems. These metrics, however, fail to account for a system's ability to turn, a key component in a system's ability to move a confined environment and an important factor in optimal motion planning. To explore turning strokes for a locomoting system, we develop a kinematic model to relate a system's shape configuration to its external velocity. We exploit this model to visualize the dynamics of the system and determine optimal strokes for multiple systems, including low Reynolds number swimmers and biological systems dominated by inertia. Understanding how shape configurations are related to external velocities enables a better understanding of biological and man made systems. Using these tools, we can justify biological system motion and determine optimal shape configurations for robots to maneuver through difficult environments.

  6. Submodular functions and optimization

    CERN Document Server

    Fujishige, Satoru

    2005-01-01

    It has widely been recognized that submodular functions play essential roles in efficiently solvable combinatorial optimization problems. Since the publication of the 1st edition of this book fifteen years ago, submodular functions have been showing further increasing importance in optimization, combinatorics, discrete mathematics, algorithmic computer science, and algorithmic economics, and there have been made remarkable developments of theory and algorithms in submodular functions. The 2nd edition of the book supplements the 1st edition with a lot of remarks and with new two chapters: "Submodular Function Minimization" and "Discrete Convex Analysis." The present 2nd edition is still a unique book on submodular functions, which is essential to students and researchers interested in combinatorial optimization, discrete mathematics, and discrete algorithms in the fields of mathematics, operations research, computer science, and economics. Key features: - Self-contained exposition of the theory of submodular ...

  7. Optimizing an emperical scoring function for transmembrane protein structure determination.

    Energy Technology Data Exchange (ETDEWEB)

    Young, Malin M.; Sale, Kenneth L.; Gray, Genetha Anne; Kolda, Tamara Gibson

    2003-10-01

    We examine the problem of transmembrane protein structure determination. Like many other questions that arise in biological research, this problem cannot be addressed by traditional laboratory experimentation alone. An approach that integrates experiment and computation is required. We investigate a procedure which states the transmembrane protein structure determination problem as a bound constrained optimization problem using a special empirical scoring function, called Bundler, as the objective function. In this paper, we describe the optimization problem and some of its mathematical properties. We compare and contrast results obtained using two different derivative free optimization algorithms.

  8. Optimal contracts for wind power producers in electricity markets

    KAUST Repository

    Bitar, E.

    2010-12-01

    This paper is focused on optimal contracts for an independent wind power producer in conventional electricity markets. Starting with a simple model of the uncertainty in the production of power from a wind turbine farm and a model for the electric energy market, we derive analytical expressions for optimal contract size and corresponding expected optimal profit. We also address problems involving overproduction penalties, cost of reserves, and utility of additional sensor information. We obtain analytical expressions for marginal profits from investing in local generation and energy storage. ©2010 IEEE.

  9. Optimal discrimination index and discrimination efficiency for essay questions.

    Science.gov (United States)

    Chan, Wing-shing

    2014-01-01

    Recommended guidelines for discrimination index of multiple choice questions are often indiscriminately applied to essay type questions also. Optimal discrimination index under normality condition for essay question is independently derived. Satisfactory region for discrimination index of essay questions with passing mark at 50% of the total is between 0.12 and 0.31 instead of 0.40 or more in the case for multiple-choice questions. Optimal discrimination index for essay question is shown to increase proportional to the range of scores. Discrimination efficiency as the ratio of the observed discrimination index over the optimal discrimination index is defined. Recommended guidelines for discrimination index of essay questions are provided.

  10. Dynamic Modeling, Optimization, and Advanced Control for Large Scale Biorefineries

    DEFF Research Database (Denmark)

    Prunescu, Remus Mihail

    plant [3]. The goal of the project is to utilize realtime data extracted from the large scale facility to formulate and validate first principle dynamic models of the plant. These models are then further exploited to derive model-based tools for process optimization, advanced control and real...... with building a plantwide model-based optimization layer, which searches for optimal values regarding the pretreatment temperature, enzyme dosage in liquefaction, and yeast seed in fermentation such that profit is maximized [7]. When biomass is pretreated, by-products are also created that affect the downstream...

  11. [Optimization of oxytetracycline biosynthesis].

    Science.gov (United States)

    Maksimova, E A; Falkov, N N; Izmaĭlov, N N; Romanchuk, N N

    1988-06-01

    It was shown that rising of temperature up to 30 degrees C at the stage of the oxytetracycline-producing organism growth promoted acceleration of the culture growth rate and increasing of the antibiotic concentration by the 114th hour of the biosynthetic process. For the apparatus used in the study optimal aeration and agitation conditions were developed. To provide optimal parameters during biosynthesis of oxytetracycline, it was recommended to use the aeration rate of 1 v/v.min and the specific mechanical power for mixing of not less than 1 kW/m3.

  12. Filters in topology optimization

    DEFF Research Database (Denmark)

    Bourdin, Blaise

    1999-01-01

    In this article, a modified (``filtered'') version of the minimum compliance topology optimization problem is studied. The direct dependence of the material properties on its pointwise density is replaced by a regularization of the density field using a convolution operator. In this setting...... it is possible to establish the existence of solutions. Moreover, convergence of an approximation by means of finite elements can be obtained. This is illustrated through some numerical experiments. The ``filtering'' technique is also shown to cope with two important numerical problems in topology optimization...

  13. Optimal exploration target zones

    CSIR Research Space (South Africa)

    Debba, Pravesh

    2008-09-01

    Full Text Available , Carranza, Stein, van der Meer Introduction to Remote Sensing Background and Objective of the study Methodology Results Optimal Exploration Target Zones Pravesh Debba1, Emmanual M.J. Carranza2, Alfred Stein2, Freek D. van der Meer2 1CSIR, Logistics... and Quantitative Methods, CSIR Built Environment 2International Institute for Geo-Information Science and Earth Observation (ITC), Hengelosestraat 99, P.O. Box 6, 7500AA Enschede, The Netherlands Optimal Exploration Target Zones Debba, Carranza, Stein, van der Meer...

  14. Advanced backend optimization

    CERN Document Server

    Touati, Sid

    2014-01-01

    This book is a summary of more than a decade of research in the area of backend optimization. It contains the latest fundamental research results in this field. While existing books are often more oriented toward Masters students, this book is aimed more towards professors and researchers as it contains more advanced subjects.It is unique in the sense that it contains information that has not previously been covered by other books in the field, with chapters on phase ordering in optimizing compilation; register saturation in instruction level parallelism; code size reduction for software pipe

  15. Analytical methods of optimization

    CERN Document Server

    Lawden, D F

    2006-01-01

    Suitable for advanced undergraduates and graduate students, this text surveys the classical theory of the calculus of variations. It takes the approach most appropriate for applications to problems of optimizing the behavior of engineering systems. Two of these problem areas have strongly influenced this presentation: the design of the control systems and the choice of rocket trajectories to be followed by terrestrial and extraterrestrial vehicles.Topics include static systems, control systems, additional constraints, the Hamilton-Jacobi equation, and the accessory optimization problem. Prereq

  16. An introduction to optimization

    CERN Document Server

    Chong, Edwin K P

    2013-01-01

    Praise for the Third Edition "". . . guides and leads the reader through the learning path . . . [e]xamples are stated very clearly and the results are presented with attention to detail.""  -MAA Reviews  Fully updated to reflect new developments in the field, the Fourth Edition of Introduction to Optimization fills the need for accessible treatment of optimization theory and methods with an emphasis on engineering design. Basic definitions and notations are provided in addition to the related fundamental background for linear algebra, geometry, and calculus.  This new

  17. ATHENA optimized coating design

    DEFF Research Database (Denmark)

    Ferreira, Desiree Della Monica; Christensen, Finn Erland; Jakobsen, Anders Clemen

    2012-01-01

    The optimization of coating design for the ATHENA mission si described and the possibility of increasing the telescope effective area in the range between 0.1 and 10 keV is investigated. An independent computation of the on-axis effective area based on the mirror design of ATHENA is performed...... in order to review the current coating baseline. The performance of several material combinations, considering a simple bi-layer, simple multilayer and linear graded multilayer coatings are tested and simulation of the mirror performance considering both the optimized coating design and the coating...

  18. Optimization of dental implantation

    Science.gov (United States)

    Dol, Aleksandr V.; Ivanov, Dmitriy V.

    2017-02-01

    Modern dentistry can not exist without dental implantation. This work is devoted to study of the "bone-implant" system and to optimization of dental prostheses installation. Modern non-invasive methods such as MRI an 3D-scanning as well as numerical calculations and 3D-prototyping allow to optimize all of stages of dental prosthetics. An integrated approach to the planning of implant surgery can significantly reduce the risk of complications in the first few days after treatment, and throughout the period of operation of the prosthesis.

  19. Distributed Optimization System

    Science.gov (United States)

    Hurtado, John E.; Dohrmann, Clark R.; Robinett, III, Rush D.

    2004-11-30

    A search system and method for controlling multiple agents to optimize an objective using distributed sensing and cooperative control. The search agent can be one or more physical agents, such as a robot, and can be software agents for searching cyberspace. The objective can be: chemical sources, temperature sources, radiation sources, light sources, evaders, trespassers, explosive sources, time dependent sources, time independent sources, function surfaces, maximization points, minimization points, and optimal control of a system such as a communication system, an economy, a crane, and a multi-processor computer.

  20. Space Derived Air Monitor

    Science.gov (United States)

    1983-01-01

    COPAMS, Commonwealth of Pennsylvania Air Monitoring System, derives from technology involved in building unmanned spacecraft. The Nimbus spacecraft carried experimental sensors to measure temperature, pressure, ozone, and water vapor, and instruments for studying solar radiation and telemetry. The process which relayed these findings to Earth formed the basis for COPAMS. The COPAMS system consists of data acquisition units which measure and record pollution level, and sense wind speed and direction, etc. The findings are relayed to a central station where the information is computerized. The system is automatic and supplemented by PAQSS, PA Air Quality Surveillance System.

  1. Automated beam model optimization.

    Science.gov (United States)

    Létourneau, Daniel; Sharpe, Michael B; Owrangi, Amir; Jaffray, David A

    2010-05-01

    The beam model in a three dimensional treatment planning system (TPS) defines virtually the mechanical and dosimetric characteristics of a treatment unit. The manual optimization of a beam model during commissioning can be a time consuming task due to its iterative nature. Furthermore, the quality of the beam model commissioning depends on the user's ability to manage multiple parameters and assess their impact on the agreement between measured and calculated dose. The objective of this work is to develop and validate the performance of an automated beam model optimization system (ABMOS) based on intensity modulated radiotherapy (IMRT) beam measurements to improve beam model accuracy while streamlining the commissioning process. The ABMOS was developed to adjust selected TPS beam model parameters iteratively to maximize the agreement between measured and calculated 2D dose maps obtained for an IMRT beam pattern. A 2D diode array with high spatial resolution detectors was used to sample the entire IMRT beam pattern in a single dose measurement. The use of an IMRT beam pattern with large number of monitor units was selected to highlight the difference between planned and delivered dose and improve the signal to noise ratio in the low dose regions. ABMOS was applied to the optimization of a beam model for an Elekta Synergy S treatment unit. The optimized beam model was validated for two anatomical sites (25 paraspinal and 25 prostate cases) using two independent patient-specific IMRT quality control (QC) methods based on ion chamber and 2D diode array measurements, respectively. The conventional approach of comparing calculated and measured beam profiles and percent-depth dose curves was also used to assess improvement in beam model after ABMOS optimization. Elements of statistical process control were applied to the process of patient-specific QC performed with the ion chamber and the 2D array to complement the model comparison. After beam model optimization with

  2. On some other preferred method for optimizing the welded joint

    Directory of Open Access Journals (Sweden)

    Pejović Branko B.

    2016-01-01

    Full Text Available The paper shows an example of performed optimization of sizes in terms of welding costs in a characteristic loaded welded joint. Hence, in the first stage, the variables and constant parameters are defined, and mathematical shape of the optimization function is determined. The following stage of the procedure defines and places the most important constraint functions that limit the design of structures, that the technologist and the designer should take into account. Subsequently, a mathematical optimization model of the problem is derived, that is efficiently solved by a proposed method of geometric programming. Further, a mathematically based thorough optimization algorithm is developed of the proposed method, with a main set of equations defining the problem that are valid under certain conditions. Thus, the primary task of optimization is reduced to the dual task through a corresponding function, which is easier to solve than the primary task of the optimized objective function. The main reason for this is a derived set of linear equations. Apparently, a correlation is used between the optimal primary vector that minimizes the objective function and the dual vector that maximizes the dual function. The method is illustrated on a computational practical example with a different number of constraint functions. It is shown that for the case of a lower level of complexity, a solution is reached through an appropriate maximization of the dual function by mathematical analysis and differential calculus.

  3. Scalable algorithms for optimal control of stochastic PDEs

    KAUST Repository

    Ghattas, Omar

    2016-01-07

    We present methods for the optimal control of systems governed by partial differential equations with infinite-dimensional uncertain parameters. We consider an objective function that involves the mean and variance of the control objective, leading to a risk-averse optimal control formulation. To make the optimal control problem computationally tractable, we employ a local quadratic approximation of the objective with respect to the uncertain parameter. This enables computation of the mean and variance of the control objective analytically. The resulting risk-averse optimization problem is formulated as a PDE-constrained optimization problem with constraints given by the forward and adjoint PDEs for the first and second-order derivatives of the quantity of interest with respect to the uncertain parameter, and with an objective that involves the trace of a covariance-preconditioned Hessian (of the objective with respect to the uncertain parameters) operator. A randomized trace estimator is used to make tractable the trace computation. Adjoint-based techniques are used to derive an expression for the infinite-dimensional gradient of the risk-averse objective function via the Lagrangian, leading to a quasi-Newton method for solution of the optimal control problem. A specific problem of optimal control of a linear elliptic PDE that describes flow of a fluid in a porous medium with uncertain permeability field is considered. We present numerical results to study the consequences of the local quadratic approximation and the efficiency of the method.

  4. Optimization of Moving Coil Actuators for Digital Displacement Machines

    DEFF Research Database (Denmark)

    Nørgård, Christian; Bech, Michael Møller; Roemer, Daniel Beck

    2016-01-01

    This paper focuses on deriving an optimal moving coil actuator design, used as force pro-ducing element in hydraulic on/off valves for Digital Displacement machines. Different moving coil actuator geometry topologies (permanent magnet placement and magnetiza-tion direction) are optimized for actu......This paper focuses on deriving an optimal moving coil actuator design, used as force pro-ducing element in hydraulic on/off valves for Digital Displacement machines. Different moving coil actuator geometry topologies (permanent magnet placement and magnetiza-tion direction) are optimized...... for actuating annular seat valves in a digital displacement machine. The optimization objectives are to the minimize the actuator power, the valve flow losses and the height of the actuator. Evaluation of the objective function involves static finite element simulation and simulation of an entire operation...... cycle using a single chamber Digital Displacement lumped parameter model. The optimization results shows that efficient operation is achievable using all of the proposed moving coil geometries, however some geometries require more space and actuator power. The most appealing of the optimized actuator...

  5. Multidisciplinary design optimization of mechatronic vehicles with active suspensions

    Science.gov (United States)

    He, Yuping; McPhee, John

    2005-05-01

    A multidisciplinary optimization method is applied to the design of mechatronic vehicles with active suspensions. The method is implemented in a GA-A'GEM-MATLAB simulation environment in such a way that the linear mechanical vehicle model is designed in a multibody dynamics software package, i.e. A'GEM, the controllers and estimators are constructed using linear quadratic Gaussian (LQG) method, and Kalman filter algorithm in Matlab, then the combined mechanical and control model is optimized simultaneously using a genetic algorithm (GA). The design variables include passive parameters and control parameters. In the numerical optimizations, both random and deterministic road inputs and both perfect measurement of full state variables and estimated limited state variables are considered. Optimization results show that the active suspension systems based on the multidisciplinary optimization method have better overall performance than those derived using conventional design methods with the LQG algorithm.

  6. Inferring biomolecular interaction networks based on convex optimization.

    Science.gov (United States)

    Han, Soohee; Yoon, Yeoin; Cho, Kwang-Hyun

    2007-10-01

    We present an optimization-based inference scheme to unravel the functional interaction structure of biomolecular components within a cell. The regulatory network of a cell is inferred from the data obtained by perturbation of adjustable parameters or initial concentrations of specific components. It turns out that the identification procedure leads to a convex optimization problem with regularization as we have to achieve the sparsity of a network and also reflect any a priori information on the network structure. Since the convex optimization has been well studied for a long time, a variety of efficient algorithms were developed and many numerical solvers are freely available. In order to estimate time derivatives from discrete-time samples, a cubic spline fitting is incorporated into the proposed optimization procedure. Throughout simulation studies on several examples, it is shown that the proposed convex optimization scheme can effectively uncover the functional interaction structure of a biomolecular regulatory network with reasonable accuracy.

  7. Reference-shaping adaptive control by using gradient descent optimizers.

    Science.gov (United States)

    Alagoz, Baris Baykant; Kavuran, Gurkan; Ates, Abdullah; Yeroglu, Celaleddin

    2017-01-01

    This study presents a model reference adaptive control scheme based on reference-shaping approach. The proposed adaptive control structure includes two optimizer processes that perform gradient descent optimization. The first process is the control optimizer that generates appropriate control signal for tracking of the controlled system output to a reference model output. The second process is the adaptation optimizer that performs for estimation of a time-varying adaptation gain, and it contributes to improvement of control signal generation. Numerical update equations derived for adaptation gain and control signal perform gradient descent optimization in order to decrease the model mismatch errors. To reduce noise sensitivity of the system, a dead zone rule is applied to the adaptation process. Simulation examples show the performance of the proposed Reference-Shaping Adaptive Control (RSAC) method for several test scenarios. An experimental study demonstrates application of method for rotor control.

  8. Optimal Control Of Nonlinear Wave Energy Point Converters

    DEFF Research Database (Denmark)

    Nielsen, Søren R.K.; Zhou, Qiang; Kramer, Morten

    2013-01-01

    In this paper the optimal control law for a single nonlinear point absorber in irregular sea-states is derived, and proven to be a closed-loop controller with feedback from measured displacement, velocity and acceleration of the floater. However, a non-causal integral control component dependent...... on future velocities appears in the optimal control law, rendering the optimal control law less useful for real time implementation. To circumvent this problem a causal closed-loop controller with the same feedback information is proposed, based on a slight modification of the optimal control law. The basic...... idea behind the control strategy is to enforce the stationary velocity response of the absorber into phase with the wave excitation force at any time. The controller is optimal under monochromatic wave excitation. It is demonstrated that the devised causal controller, in plane irregular sea states...

  9. The expanded Lagrangian system for constrained optimization problems

    Science.gov (United States)

    Poore, A. B.; Al-Hassan, Q.

    1988-01-01

    Smooth penalty functions can be combined with numerical continuation/bifurcation techniques to produce a class of robust and fast algorithms for constrained optimization problems. The key to the development of these algorithms is the Expanded Lagrangian System which is derived and analyzed in this work. This parameterized system of nonlinear equations contains the penalty path as a solution, provides a smooth homotopy into the first-order necessary conditions, and yields a global optimization technique. Furthermore, the inevitable ill-conditioning present in a sequential optimization algorithm is removed for three penalty methods: the quadratic penalty function for equality constraints, and the logarithmic barrier function (an interior method) and the quadratic loss function (an interior method) for inequality constraints. Although these techniques apply to optimization in general and to linear and nonlinear programming, calculus of variations, optimal control and parameter identification in particular, the development is primarily within the context of nonlinear programming.

  10. Bayesian Regression with Network Prior: Optimal Bayesian Filtering Perspective.

    Science.gov (United States)

    Qian, Xiaoning; Dougherty, Edward R

    2016-12-01

    The recently introduced intrinsically Bayesian robust filter (IBRF) provides fully optimal filtering relative to a prior distribution over an uncertainty class ofjoint random process models, whereas formerly the theory was limited to model-constrained Bayesian robust filters, for which optimization was limited to the filters that are optimal for models in the uncertainty class. This paper extends the IBRF theory to the situation where there are both a prior on the uncertainty class and sample data. The result is optimal Bayesian filtering (OBF), where optimality is relative to the posterior distribution derived from the prior and the data. The IBRF theories for effective characteristics and canonical expansions extend to the OBF setting. A salient focus of the present work is to demonstrate the advantages of Bayesian regression within the OBF setting over the classical Bayesian approach in the context otlinear Gaussian models.

  11. Duality based contact shape optimization

    DEFF Research Database (Denmark)

    Vondrák, Vít; Dostal, Zdenek; Rasmussen, John

    2001-01-01

    An implementation of semi-analytic method for the sensitivity analysis in contact shape optimization without friction is described. This method is then applied to the contact shape optimization.......An implementation of semi-analytic method for the sensitivity analysis in contact shape optimization without friction is described. This method is then applied to the contact shape optimization....

  12. Certain legal aspects of derivatives.

    Science.gov (United States)

    Cloney, T J

    1994-01-01

    This article discusses legal characteristics of derivatives that a not-for-profit health care company may use in a conduit financing in which a governmental issuer issues bonds for the benefit of a health care company. This article also presents the Master Agreement promulgated by the International Swaps and Derivatives Association; discusses how to get out of a derivative; discusses the status of a derivative after insolvency of a counterparty; presents disclosure issues relating to documents prepared in connection with an issue of bonds; and describes the treatment of derivatives under commodities regulations. It concludes with a presentation of possible new regulations applying to derivatives.

  13. Generalized Derivations and Bilocal Jordan Derivations of Nest Algebras

    Directory of Open Access Journals (Sweden)

    Dangui Yan

    2011-01-01

    Full Text Available Let H be a complex Hilbert space and B(H the collection of all linear bounded operators, A is the closed subspace lattice including 0 an H, then A is a nest, accordingly alg A={T∈B(H:TN⊆N,  ∀N∈A} is a nest algebra. It will be shown that of nest algebra, generalized derivations are generalized inner derivations, and bilocal Jordan derivations are inner derivations.

  14. Bayesian optimization for materials science

    CERN Document Server

    Packwood, Daniel

    2017-01-01

    This book provides a short and concise introduction to Bayesian optimization specifically for experimental and computational materials scientists. After explaining the basic idea behind Bayesian optimization and some applications to materials science in Chapter 1, the mathematical theory of Bayesian optimization is outlined in Chapter 2. Finally, Chapter 3 discusses an application of Bayesian optimization to a complicated structure optimization problem in computational surface science. Bayesian optimization is a promising global optimization technique that originates in the field of machine learning and is starting to gain attention in materials science. For the purpose of materials design, Bayesian optimization can be used to predict new materials with novel properties without extensive screening of candidate materials. For the purpose of computational materials science, Bayesian optimization can be incorporated into first-principles calculations to perform efficient, global structure optimizations. While re...

  15. Acquiring Knowledge of Derived Nominals and Derived Adjectives in Context

    Science.gov (United States)

    Marinellie, Sally A.; Kneile, Lynn A.

    2012-01-01

    Purpose: This research investigated children's ability to acquire semantic and syntactic knowledge of derived nominals and derived adjectives in the context of short passages. The study also investigated the relation of morphological awareness and the ability to acquire knowledge of derived words in context. Method: A total of 106 children in…

  16. Experts' Understanding of Partial Derivatives Using the Partial Derivative Machine

    Science.gov (United States)

    Roundy, David; Weber, Eric; Dray, Tevian; Bajracharya, Rabindra R.; Dorko, Allison; Smith, Emily M.; Manogue, Corinne A.

    2015-01-01

    Partial derivatives are used in a variety of different ways within physics. Thermodynamics, in particular, uses partial derivatives in ways that students often find especially confusing. We are at the beginning of a study of the teaching of partial derivatives, with a goal of better aligning the teaching of multivariable calculus with the needs of…

  17. Synthesis of F-18 labeled raloxifene derivative

    Energy Technology Data Exchange (ETDEWEB)

    Lee, K. C.; Moon, B. S.; Jun, K. S. [KIRAMS, Seoul (Korea, Republic of); Lee, J. H.; Ji, D. Y. [Inha University, Incheon (Korea, Republic of)

    2005-07-01

    Raloxifene, [6-hydroxy-2-(4-hydroxy-phenyl) benzo [b] thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)phenyl] methanone, a tissue-selective estrogen mixed agonist/antagonist, classified as a selective estrogen receptor modulator (SERM), is currently under clinical evaluation for the prevention and treatment of postmenopausal osteoporosis, breast cancer, uterine dysfunction, and other disorders of the female reproductive system. Based on SAR studies of substituted raloxifenes, we synthesized 3 kinds of fluoroalkylated raloxifene derivatives. These compounds show high relative binding affinities (RBA) to the estrogen receptor in vitro (RBA of estradiol = 100%). The RBA values for compounds 1, 2 and 3 are 89, 60, and 45%, respectively, which are all higher than that of raloxifene itself (34%). Among these compounds, we selected to take the best RBA value one and F-18 labeled. Using 2 kinds of labeling method ; 1) Radiolabeling using [{sup 18}F]KF was carried out in anhydrous acetonitrile for 10 min at 120 .deg. C. 2) Radiolabeling using [{sup 18}F]KF was carried out in anhydrous acetonitrile for 15 min at 120 .deg. C in ionic liquid, [bmim][OTf]. Deprotection step added 1N HCl and reacted for 3 min at 120 .deg. C. [{sup 18}F]Fluoroethyl raloxifene derivative obtained 5-23% decay corrected labeling yield by HPLC system (C18 xterra, 10 i, 34% Acetonitrile/0.1 M formate buffer, flow rate: 4 mL/1 min, collection time : 28-29 min) and total time was around 70 min. Fluoroethyl raloxifene derivative has the best RBA value among the other synthesized derivatives and chose it for radiolabeling. [{sup 18}F]Fluoroethyl raloxifene derivative prepared 5-23% decay corrected labeling yield. This preparation is on going for labeling optimizing and preparing of in vitro and in vivo test.

  18. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan; Strulik, Holger

    the representative consumer is subject to physiological aging. In modeling aging we draw on recent research in the fields of biology and medicine. The speed of the aging process, and thus the time of death, are endogenously determined by optimal health investments. We calibrate the model to US data and proceed...

  19. Solving nonconvex optimization problems

    Czech Academy of Sciences Publication Activity Database

    Henrion, Didier; Lasserre, J. B.

    2004-01-01

    Roč. 24, č. 3 (2004), s. 72-83 ISSN 0272-1708 R&D Projects: GA ČR GA102/02/0709 Institutional research plan: CEZ:AV0Z1075907 Keywords : nonconvex optimization * LMI methods Subject RIV: BC - Control Systems Theory Impact factor: 1.803, year: 2004

  20. Danfoss: Scroll Optimization

    DEFF Research Database (Denmark)

    Gravesen, Jens; Henriksen, Christian; Howell, Peter

    1998-01-01

    The standard scroll compressor consists of two identical spirals (circle involutes) running inside each other.The task from Danfoss was to investigate how a change in the basic geometry of the scrolss and the orbit influence the compressor performnce and efficiency, and then try to optimize...

  1. Optimization of Pipe Networks

    DEFF Research Database (Denmark)

    Hansen, C. T.; Madsen, Kaj; Nielsen, Hans Bruun

    1991-01-01

    algorithm using successive linear programming is presented. The performance of the algorithm is illustrated by optimizing a network with 201 pipes and 172 nodes. It is concluded that the new algorithm seems to be very efficient and stable, and that it always finds a solution with a cost near the best...

  2. Optimal Ski Jump

    Science.gov (United States)

    Rebilas, Krzysztof

    2013-01-01

    Consider a skier who goes down a takeoff ramp, attains a speed "V", and jumps, attempting to land as far as possible down the hill below (Fig. 1). At the moment of takeoff the angle between the skier's velocity and the horizontal is [alpha]. What is the optimal angle [alpha] that makes the jump the longest possible for the fixed magnitude of the…

  3. Optimal Central Bank Transparency

    NARCIS (Netherlands)

    van der Cruijsen, C.A.B.; Eijffinger, S.C.W.; Hoogduin, L.H.

    2008-01-01

    Should central banks increase their degree of transparency any further? We show that there is likely to be an optimal intermediate degree of central bank transparency. Up to this optimum more transparency is desirable: it improves the quality of private sector inflation forecasts. But beyond the

  4. Optimizing Computer Technology Integration

    Science.gov (United States)

    Dillon-Marable, Elizabeth; Valentine, Thomas

    2006-01-01

    The purpose of this study was to better understand what optimal computer technology integration looks like in adult basic skills education (ABSE). One question guided the research: How is computer technology integration best conceptualized and measured? The study used the Delphi method to map the construct of computer technology integration and…

  5. Is Optimism Real?

    Science.gov (United States)

    Simmons, Joseph P.; Massey, Cade

    2012-01-01

    Is optimism real, or are optimistic forecasts just cheap talk? To help answer this question, we investigated whether optimistic predictions persist in the face of large incentives to be accurate. We asked National Football League football fans to predict the winner of a single game. Roughly half (the partisans) predicted a game involving their…

  6. Optimal Quadratic Programming Algorithms

    CERN Document Server

    Dostal, Zdenek

    2009-01-01

    Quadratic programming (QP) is one technique that allows for the optimization of a quadratic function in several variables in the presence of linear constraints. This title presents various algorithms for solving large QP problems. It is suitable as an introductory text on quadratic programming for graduate students and researchers

  7. Optimizing clozapine treatment

    DEFF Research Database (Denmark)

    Nielsen, J; Damkier, P; Lublin, H

    2011-01-01

    Clozapine treatment remains the gold standard for treatment-resistant schizophrenia, but treatment with clozapine is associated with several side-effects that complicate the use of the drug. This clinical overview aims to provide psychiatrists with knowledge about how to optimize clozapine...... treatment. Relevant strategies for reducing side-effects and increasing the likelihood of response are discussed....

  8. Numerical Optimization in Microfluidics

    DEFF Research Database (Denmark)

    Jensen, Kristian Ejlebjærg

    2017-01-01

    Numerical modelling can illuminate the working mechanism and limitations of microfluidic devices. Such insights are useful in their own right, but one can take advantage of numerical modelling in a systematic way using numerical optimization. In this chapter we will discuss when and how numerical...

  9. Optimization of reactive mufflers

    Science.gov (United States)

    Komkin, A. I.

    2010-05-01

    A new approach to optimization of reactive mufflers, which is based on use of muffler prototype with nondimensional geometrical parameters and integral criterion of acoustic performance of mufflers, is proposed. Implementation of the approach using the example of chamber mufflers is considered.

  10. Optimal design of beams

    Science.gov (United States)

    Samala, Shivakumar

    Beams are basic structural components that are capable of withstanding load primarily by resisting bending. Unlike Euler-Bernoulli beams, Timoshenko beams undergo both shear deformation and rotational effects, making it suitable for analyzing the behavior of thick or short beams, composite beams and beams that are subjected to high frequency excitation when their wave length becomes shorter. This thesis work focuses on optimal design of straight and tapered Timoshenko beams under static and dynamic constraints for rectangular and circular cross sections. In this work Timoshenko beam static and dynamic equations were studied. The finite element method was used for static and dynamic analysis of the beam. In finite element method to overcome the numerical problem in shear locking, cubic interpolation of displacement and an interdependent quadratic approximation of rotation has been considered. In order to optimize the weight of the beam with static and dynamic constraints three sets of optimizations were done. The design variables are length, cross sectional width and height, with objective function as mass, static deflection constraints were used. The second optimization set was using dynamic constraints and the last set was using both static and dynamic constraints.

  11. Optimalization of IGBT Communication

    Directory of Open Access Journals (Sweden)

    Pavol Spanik

    2002-01-01

    Full Text Available The paper presents IGBT switch off process in order to reduce power loss in the structure. The soft switching method using switch-off after current reduction is used. Process mentioned above is optimized to minimize the power loss that is determined by experiment. Results obtained in the experiment can be helpful in a converter and controller design process.

  12. Optimal fault signal estimation

    NARCIS (Netherlands)

    Stoorvogel, Antonie Arij; Niemann, H.H.; Saberi, A.; Sannuti, P.

    2002-01-01

    We consider here both fault identification and fault signal estimation. Regarding fault identification, we seek either exact or almost fault identification. On the other hand, regarding fault signal estimation, we seek either $H_2$ optimal, $H_2$ suboptimal or Hinfinity suboptimal estimation. By

  13. Computing Optimal Morse Matchings

    OpenAIRE

    Joswig, Michael; Pfetsch, Marc E.

    2004-01-01

    Morse matchings capture the essential structural information of discrete Morse functions. We show that computing optimal Morse matchings is NP-hard and give an integer programming formulation for the problem. Then we present polyhedral results for the corresponding polytope and report on computational results.

  14. Optimal Facility-Location.

    Science.gov (United States)

    Goldman, A J

    2006-01-01

    Dr. Christoph Witzgall, the honoree of this Symposium, can count among his many contributions to applied mathematics and mathematical operations research a body of widely-recognized work on the optimal location of facilities. The present paper offers to non-specialists a sketch of that field and its evolution, with emphasis on areas most closely related to Witzgall's research at NBS/NIST.

  15. Advanced BDD optimization

    CERN Document Server

    Ebendt, Rudiger; Drechsler, Rolf

    2005-01-01

    BDD and SAT are major concepts in VLSI CADNew objective functions for design space exploration require new algorithms for BDD optimizationLatest trend: fusion of the concepts BDD and SATMajor impulses come from Artificial Intelligence (AI)Unifying view, transfers the latest theoretical insights into practical applications.

  16. Towards Optimal Transport Networks

    Directory of Open Access Journals (Sweden)

    Erik P. Vargo

    2010-08-01

    Full Text Available Our ultimate goal is to design transportation net- works whose dynamic performance metrics (e.g. pas- senger throughput, passenger delay, and insensitivity to weather disturbances are optimized. Here the fo- cus is on optimizing static features of the network that are known to directly affect the network dynamics. First, we present simulation results which support a connection between maximizing the first non-trivial eigenvalue of a network's Laplacian and superior air- port network performance. Then, we explore the ef- fectiveness of a tabu search heuristic for optimizing this metric by comparing experimental results to the- oretical upper bounds. We also consider generating upper bounds on a network's algebraic connectivity via the solution of semidefinite programming (SDP relaxations. A modification of an existing subgraph extraction algorithm is implemented to explore the underlying regional structures in the U.S. airport net- work, with the hope that the resulting localized struc- tures can be optimized independently and reconnected via a "backbone" network to achieve superior network performance.

  17. Optimizing Running Performance.

    Science.gov (United States)

    Widule, Carol J.

    1989-01-01

    The optimization of step length and step rate (frequency) is essential for sprinters. This article analyzes data that compare step rate and step length to height, as a function of running speed, for ten elite runners. How results of such analyses can be used in training runners is also discussed. (IAH)

  18. Spatiotemporal AED Location Optimization

    NARCIS (Netherlands)

    Chan, Timothy C.Y.; Sun, Christopher L.F.; Demirtas, Derya; Morrison, Laurie J.; Brooks, Steven C.

    2015-01-01

    Background: Mathematical optimization can be used to plan future AED placement to maximize out-of-hospital cardiac arrest (OHCA) coverage. Many public access AEDs are placed in locations without 24/7 access. AED coverage can be overestimated unless temporal availability is considered. Objective: To

  19. Optimal Sampling and Interpolation

    NARCIS (Netherlands)

    Shekhawat, Hanumant

    2012-01-01

    The main objective in this thesis is to design optimal samplers, downsamplers and interpolators (holds) which are required in signal processing. The sampled-data system theory is used to fulfill this objective in a generic setup. Signal processing, which includes signal transmission, storage and

  20. Optimal drying of salt cod; Optimal Klippfisktoerking

    Energy Technology Data Exchange (ETDEWEB)

    Claussen, Ingrid Camilla; Magnussen, Ola M.

    2008-12-15

    The aim of the project is to collect technical and technological data on drying in order to establish optimal drying conditions for the production of salted and dried cod. Optimal drying conditions form the basis for ensuring even drying after leaving the drying-room, increased productivity and reduced energy- and running expenses for the production of salted and dry ed cod. The measured results form the basis for the choice of process plan and decision for drying time for a given raw material and size of fish. Air temperature, humidity and air velocity in the drying-room together with the raw material and salt maturing affect the drying time in different ways. The aim is to find the concrete effect of these parameters. During the project trials have been done on salt fish of pacific cod (Gadus macrocephalus), cod (Gadus morhua) and pollock (Pollachius virens) in a laboratory scale tunnel-dryer. The report highlights the importance of (a) after-drying during storing and maturing, (b) increased cut and (c) varying salt maturing. The results demonstrate that the air velocity has little influence on drying velocity once the surface water has been removed from the product, while air humidity has a certain influence. This entails the possibility of a change in drying process and a reduction of energy and running costs by giving the fish a finishing drying in separate storage or by reducing the air velocity after 24 hours. Size and surface influence considerably on drying velocity, and it is observed that small fish dries much faster than large fish. Fish of about 1.5 kilograms dries to a water content of 52% after approximately 50 hours, while equivalent fish of 4.5 kilograms need approximately 75 hours at a drying temperature of 22 degrees Celsius and 40 % R H. By increasing the drying surface measurements show an increase of 2.5% in loss of weight for small fish (1.5 kilograms) after 2 days of drying. The final content of water in fish that had been matured for 24

  1. Optimal GENCO bidding strategy

    Science.gov (United States)

    Gao, Feng

    Electricity industries worldwide are undergoing a period of profound upheaval. The conventional vertically integrated mechanism is being replaced by a competitive market environment. Generation companies have incentives to apply novel technologies to lower production costs, for example: Combined Cycle units. Economic dispatch with Combined Cycle units becomes a non-convex optimization problem, which is difficult if not impossible to solve by conventional methods. Several techniques are proposed here: Mixed Integer Linear Programming, a hybrid method, as well as Evolutionary Algorithms. Evolutionary Algorithms share a common mechanism, stochastic searching per generation. The stochastic property makes evolutionary algorithms robust and adaptive enough to solve a non-convex optimization problem. This research implements GA, EP, and PS algorithms for economic dispatch with Combined Cycle units, and makes a comparison with classical Mixed Integer Linear Programming. The electricity market equilibrium model not only helps Independent System Operator/Regulator analyze market performance and market power, but also provides Market Participants the ability to build optimal bidding strategies based on Microeconomics analysis. Supply Function Equilibrium (SFE) is attractive compared to traditional models. This research identifies a proper SFE model, which can be applied to a multiple period situation. The equilibrium condition using discrete time optimal control is then developed for fuel resource constraints. Finally, the research discusses the issues of multiple equilibria and mixed strategies, which are caused by the transmission network. Additionally, an advantage of the proposed model for merchant transmission planning is discussed. A market simulator is a valuable training and evaluation tool to assist sellers, buyers, and regulators to understand market performance and make better decisions. A traditional optimization model may not be enough to consider the distributed

  2. Topology optimization using bi-directional evolutionary structural optimization based on the element-free Galerkin method

    Science.gov (United States)

    Shobeiri, Vahid

    2016-03-01

    In this article, the bi-directional evolutionary structural optimization (BESO) method based on the element-free Galerkin (EFG) method is presented for topology optimization of continuum structures. The mathematical formulation of the topology optimization is developed considering the nodal strain energy as the design variable and the minimization of compliance as the objective function. The EFG method is used to derive the shape functions using the moving least squares approximation. The essential boundary conditions are enforced by the method of Lagrange multipliers. Several topology optimization problems are presented to show the effectiveness of the proposed method. Many issues related to topology optimization of continuum structures, such as chequerboard patterns and mesh dependency, are studied in the examples.

  3. Optimal Schedules in Multitask Motor Learning.

    Science.gov (United States)

    Lee, Jeong Yoon; Oh, Youngmin; Kim, Sung Shin; Scheidt, Robert A; Schweighofer, Nicolas

    2016-04-01

    Although scheduling multiple tasks in motor learning to maximize long-term retention of performance is of great practical importance in sports training and motor rehabilitation after brain injury, it is unclear how to do so. We propose here a novel theoretical approach that uses optimal control theory and computational models of motor adaptation to determine schedules that maximize long-term retention predictively. Using Pontryagin's maximum principle, we derived a control law that determines the trial-by-trial task choice that maximizes overall delayed retention for all tasks, as predicted by the state-space model. Simulations of a single session of adaptation with two tasks show that when task interference is high, there exists a threshold in relative task difficulty below which the alternating schedule is optimal. Only for large differences in task difficulties do optimal schedules assign more trials to the harder task. However, over the parameter range tested, alternating schedules yield long-term retention performance that is only slightly inferior to performance given by the true optimal schedules. Our results thus predict that in a large number of learning situations wherein tasks interfere, intermixing tasks with an equal number of trials is an effective strategy in enhancing long-term retention.

  4. Fast numerical methods for robust optimal design

    Science.gov (United States)

    Xiu, Dongbin

    2008-06-01

    A fast numerical approach for robust design optimization is presented. The core of the method is based on the state-of-the-art fast numerical methods for stochastic computations with parametric uncertainty. These methods employ generalized polynomial chaos (gPC) as a high-order representation for random quantities and a stochastic Galerkin (SG) or stochastic collocation (SC) approach to transform the original stochastic governing equations to a set of deterministic equations. The gPC-based SG and SC algorithms are able to produce highly accurate stochastic solutions with (much) reduced computational cost. It is demonstrated that they can serve as efficient forward problem solvers in robust design problems. Possible alternative definitions for robustness are also discussed. Traditional robust optimization seeks to minimize the variance (or standard deviation) of the response function while optimizing its mean. It can be shown that although variance can be used as a measure of uncertainty, it is a weak measure and may not fully reflect the output variability. Subsequently a strong measure in terms of the sensitivity derivatives of the response function is proposed as an alternative robust optimization definition. Numerical examples are provided to demonstrate the efficiency of the gPC-based algorithms, in both the traditional weak measure and the newly proposed strong measure.

  5. Algorithms for optimizing CT fluence control

    Science.gov (United States)

    Hsieh, Scott S.; Pelc, Norbert J.

    2014-03-01

    The ability to customize the incident x-ray fluence in CT via beam-shaping filters or mA modulation is known to improve image quality and/or reduce radiation dose. Previous work has shown that complete control of x-ray fluence (ray-by-ray fluence modulation) would further improve dose efficiency. While complete control of fluence is not currently possible, emerging concepts such as dynamic attenuators and inverse-geometry CT allow nearly complete control to be realized. Optimally using ray-by-ray fluence modulation requires solving a very high-dimensional optimization problem. Most optimization techniques fail or only provide approximate solutions. We present efficient algorithms for minimizing mean or peak variance given a fixed dose limit. The reductions in variance can easily be translated to reduction in dose, if the original variance met image quality requirements. For mean variance, a closed form solution is derived. The peak variance problem is recast as iterated, weighted mean variance minimization, and at each iteration it is possible to bound the distance to the optimal solution. We apply our algorithms in simulations of scans of the thorax and abdomen. Peak variance reductions of 45% and 65% are demonstrated in the abdomen and thorax, respectively, compared to a bowtie filter alone. Mean variance shows smaller gains (about 15%).

  6. Smell Detection Agent Based Optimization Algorithm

    Science.gov (United States)

    Vinod Chandra, S. S.

    2016-09-01

    In this paper, a novel nature-inspired optimization algorithm has been employed and the trained behaviour of dogs in detecting smell trails is adapted into computational agents for problem solving. The algorithm involves creation of a surface with smell trails and subsequent iteration of the agents in resolving a path. This algorithm can be applied in different computational constraints that incorporate path-based problems. Implementation of the algorithm can be treated as a shortest path problem for a variety of datasets. The simulated agents have been used to evolve the shortest path between two nodes in a graph. This algorithm is useful to solve NP-hard problems that are related to path discovery. This algorithm is also useful to solve many practical optimization problems. The extensive derivation of the algorithm can be enabled to solve shortest path problems.

  7. On Optimal Shapes in Materials and Structures

    DEFF Research Database (Denmark)

    Pedersen, Pauli

    2000-01-01

    of parametrization, the problem of material/hole design for maximum bulk modulus is analysed. A simple optimality criterion is derived and with a simple superelliptic parametrization, agreement with Hashin-Shtrikman bounds are found. More general examples including nonequal principal strains, nonlinear elasticity...... that these three objectives have the same solution, at least within the limits of geometrical constraints, including the parametrization. Without involving stress/strain fields, the proof holds for 3D-problems, for power-law nonlinear elasticity and for anisotropic elasticity. To clarify the importance...... and orthotropic elasticity show the versatility of the optimality criterion approach. In spite of this, the mathematical programming approach will be used in the future study of the multiparameter and/or multipurpose problems....

  8. Humanization and simultaneous optimization of monoclonal antibody.

    Science.gov (United States)

    Kuramochi, T; Igawa, T; Tsunoda, H; Hattori, K

    2014-01-01

    Antibody humanization is an essential technology for reducing the potential risk of immunogenicity associated with animal-derived antibodies and has been applied to a majority of the therapeutic antibodies on the market. For developing an antibody molecule as a pharmaceutical at the current biotechnology level, however, other properties also have to be considered in parallel with humanization in antibody generation and optimization. This section describes the critical properties of therapeutic antibodies that should be sufficiently qualified, including immunogenicity, binding affinity, physiochemical stability, expression in host cells and pharmacokinetics, and the basic methodologies of antibody engineering involved. By simultaneously optimizing the antibody molecule in the light of these properties, it should prove possible to shorten the research and development period necessary to identify a highly qualified clinical candidate and consequently accelerate the start of the clinical trial.

  9. Airway Tree Extraction with Locally Optimal Paths

    DEFF Research Database (Denmark)

    Lo, Pechin Chien Pau; Sporring, Jon; Pedersen, Jesper Johannes Holst

    2009-01-01

    This paper proposes a method to extract the airway tree from CT images by continually extending the tree with locally optimal paths. This is in contrast to commonly used region growing based approaches that only search the space of the immediate neighbors. The result is a much more robust method...... for tree extraction that can overcome local occlusions. The cost function for obtaining the optimal paths takes into account of an airway probability map as well as measures of airway shape and orientation derived from multi-scale Hessian eigen analysis on the airway probability. Significant improvements...... were achieved compared to a region growing based method, with up to 36% longer trees at a slight increase of false positive rate....

  10. Discrete optimization in architecture architectural & urban layout

    CERN Document Server

    Zawidzki, Machi

    2016-01-01

    This book presents three projects that demonstrate the fundamental problems of architectural design and urban composition – the layout design, evaluation and optimization. Part I describes the functional layout design of a residential building, and an evaluation of the quality of a town square (plaza). The algorithm for the functional layout design is based on backtracking using a constraint satisfaction approach combined with coarse grid discretization. The algorithm for the town square evaluation is based on geometrical properties derived directly from its plan. Part II introduces a crowd-simulation application for the analysis of escape routes on floor plans, and optimization of a floor plan for smooth crowd flow. The algorithms presented employ agent-based modeling and cellular automata.

  11. Optimal design of centered squeeze film dampers

    Science.gov (United States)

    Nataraj, C.; Ashrafiuon, H.

    1993-04-01

    A two degree-of-freedom model, consisting of a rigid rotor supported on rigid bearings which are in turn supported on squeeze film dampers, is considered. Isotropic centering springs are assumed resulting in a steady synchronous centered circular response for the rotor. The resulting nonlinear system is modeled in nondimensional form. The transmissibility ratio of the system as well as the power dissipated are minimized for various values of unbalance and at several speeds, with the squeeze film bearing parameter as the primary design variable. Expressions are derived for linear variational stability of the circular orbit, and are imposed as constraints in the optimization process. The dependence of the optimal configuration on speed and unbalance is discussed.

  12. Elevation Derivatives for National Applications

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Elevation Derivatives for National Applications (EDNA) is a seamless, nationwide, multi-layered three-dimensional (3D) hydrologic database derived from a version of...

  13. Experts’ understanding of partial derivatives using the partial derivative machine

    Directory of Open Access Journals (Sweden)

    David Roundy

    2015-09-01

    Full Text Available [This paper is part of the Focused Collection on Upper Division Physics Courses.] Partial derivatives are used in a variety of different ways within physics. Thermodynamics, in particular, uses partial derivatives in ways that students often find especially confusing. We are at the beginning of a study of the teaching of partial derivatives, with a goal of better aligning the teaching of multivariable calculus with the needs of students in STEM disciplines. In this paper, we report on an initial study of expert understanding of partial derivatives across three disciplines: physics, engineering, and mathematics. We report on the central research question of how disciplinary experts understand partial derivatives, and how their concept images of partial derivatives differ, with a focus on experimentally measured quantities. Using the partial derivative machine (PDM, we probed expert understanding of partial derivatives in an experimental context without a known functional form. In particular, we investigated which representations were cued by the experts’ interactions with the PDM. Whereas the physicists and engineers were quick to use measurements to find a numeric approximation for a derivative, the mathematicians repeatedly returned to speculation as to the functional form; although they were comfortable drawing qualitative conclusions about the system from measurements, they were reluctant to approximate the derivative through measurement. On a theoretical front, we found ways in which existing frameworks for the concept of derivative could be expanded to include numerical approximation.

  14. Dynamic Stability Derivatives

    Science.gov (United States)

    2015-06-01

    Pitching Rotations From Table 3-1Error! Reference source not found.for the pitch-rate characteristic motion  02 cos 1 cos( )a Uz q t      3-3 For...variables can be neglected. 3. All derivatives with respect to the rates-of-change of the motion variables may be neglected except uX  , uZ  , uM  , wX...sin( ) cos( ) u uZ Z Zu U         and 0cos( )v vY Y Yv U        The remaining relationships are obtained in the same manner and are

  15. SEMANTIC DERIVATION OF BORROWINGS

    Directory of Open Access Journals (Sweden)

    Shigapova, F.F.

    2017-09-01

    Full Text Available The author carried out the contrastive analysis of the word спикер borrowed into Russian from English and the English word speaker. The findings of the analysis include confirm (1 different derivational abilities and functions of the borrowed word and the native word; (2 distinctive features in the definitions, i.e. semantic structures, registered in monolingual non-abridged dictionaries; (3 heterogeneous parameters of frequencies recorded in the National Corpus of the Russian language and the British National Corpus; (4 absence of bilingual equivalent collocations with words спикер and speaker. The collocations with words studied revealed new lexical and connotative senses in the meaning of the word. Relevance of the study conducted is justified by the new facts revealed about the semantic adaptation of the borrowed word in the system of the Russian language and its paradigmatic and syntagmatic connections in the system of the recipient language.

  16. On Q-derived polynomials

    NARCIS (Netherlands)

    R.J. Stroeker (Roel)

    2002-01-01

    textabstractA Q-derived polynomial is a univariate polynomial, defined over the rationals, with the property that its zeros, and those of all its derivatives are rational numbers. There is a conjecture that says that Q-derived polynomials of degree 4 with distinct roots for themselves and all their

  17. On Q-derived polynomials

    NARCIS (Netherlands)

    R.J. Stroeker (Roel)

    2006-01-01

    textabstractA Q-derived polynomial is a univariate polynomial, defined over the rationals, with the property that its zeros, and those of all its derivatives are rational numbers. There is a conjecture that says that Q-derived polynomials of degree 4 with distinct roots for themselves and all their

  18. Wind farm power optimization including flow variability

    DEFF Research Database (Denmark)

    Herp, Jürgen; Poulsen, Uffe Vestergaard; Greiner, Martin

    2015-01-01

    A model-based optimisation approach is used to investigate the potential gain of wind-farm power with a cooperative control strategy between the wind turbines. Based on the Jensen wake model with the Katic wake superposition rule, the potential gain for the Nysted offshore wind farm is calculated...... an optimized wind-farm control strategy, derived from a fixed wake parameter, is facing this flow variability, the potential gain reduces to 0.3–0.5%. An omnipotent control strategy, which has real-time knowledge of the actual wake flow, would be able to increase the gain in wind-farm power to 4.9%....

  19. Optimal Asset Allocation under Quadratic Loss Aversion

    OpenAIRE

    Fortin, Ines; Hlouskova, Jaroslava

    2012-01-01

    Abstract: We study the asset allocation of a quadratic loss-averse (QLA) investor and derive conditions under which the QLA problem is equivalent to the mean-variance (MV) and conditional value-at-risk (CVaR) problems. Then we solve analytically thetwo-asset problem of the QLA investor for a risk-free and a risky asset. We find that the optimal QLA investment in the risky asset is finite, strictly positive and is minimal with respect to the reference point for a value strictly larger than the...

  20. Distance Runners as Models of Optimal Health.

    Science.gov (United States)

    Elrick, H

    1981-01-01

    In brief: Distance runners are suggested as a new model for optimal health standards because normal values are now derived from the American public, which is notorious for its obesity, low level of physical fitness, bad eating habits, use of cigarettes and drugs, and high incidence of cardiovascular and other degenerative diseases. As a group, the 50 distance runners studied showed lower than normal body weight, body fat, resting heart rate, serum cholesterol and triglycerides; higher HDL cholesterol; and lower cholesterol/HDL cholesterol ratios. However, the runners who ate the average American diet sometimes had normal values.