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Sample records for hemoglobin saint mande

  1. Coupling of tertiary and quaternary changes in human hemoglobin: A 1D and 2D NMR study of hemoglobin Saint Mande (βN102Y)

    Craescu, C.T.; Blouquit, Y.; Mispelter, J.

    1990-01-01

    Hemoglobin Saint Mande (βN102Y) is a low-affinity mutant with the substitution site situated in the quaternary-sensitive α 1 β 2 interface. In adult hemoglobin the Asn102β contributes to the stability of the liganded (R) state, forming a hydrogen bond with Asp94α. The quaternary and tertiary perturbations subsequent to the Tyr for Asn substitution in monocarboxylated hemoglobin Saint Mande have been investigated by one-and two-dimensional nuclear magnetic resonance (NMR) spectroscopy. Analysis of the one-dinensional NMR spectra of the liganded and unliganded samples in 1 H 2 O provides evidence that both R and T quaternary structures of Hb Saint Mande are different from the corresponding ones in HbA. In the monocarboxylated form of the mutant hemoglobin, at acid pH, the authors have observed the disappearance of an R-type hydrogen bond and the appearance of a new one whose proton resonates like a deoxy T marker. Using two-dimensional NMR methods and on the basis of previous results on the monocarboxylated HbA, they have obtained a significant number of resonance assignments in the spectra of monocarboxylated Hb Saint Mande at pH 5.6 in the presence or absence of a strong allosteric effector, inositol hexaphosphate. This enabled us to characterize the tertiary conformational changes triggered by the quaternary-state modification. The observed structural variations are confined within the heme pocket regions but concern both the α and β subunits

  2. A 13C-NMR study of mutant hemoglobins with altered oxygen affinity

    Smith, M.L.; Norden, B.; Edlund, U.; Paul, K.-G.

    1986-01-01

    The 13 CO-NMR spectra of carbonylhemoglobins Saint Mande (β 102Asn → Tyr), Malmo (β 97His → Gln), Hotel Dieu (β 99Asp → Gly) and A o have been determined. The positions of the 13 CO resonances for hemoglobins A o , Malmo and Hotel Dieu were similar indicating similar ligand environments for all. The 13 CO resonance for the β-subunit of Saint Mande was upfield-shifted compared to the others. This is evidence that structural changes at the β102 position directly affect iron-ligand bonding as well as quaternary structure. (Auth.)

  3. Hemoglobin

    1993-03-08

    affinity, which is less at low levels of hemoglobin saturation, increases markedly as fractional saturation increases. Thus, high affinity for 02 at... diphosphoglycerate (2,3-DPG), and carbon dioxide (Co 2). Since they are linked to 02 binding, they are called oxygen-linked effectors. The oxygen...hemoglobin molecule because of the negative charge of the ions. 2,3- Diphosphoglycerate is a molecule formed during the breakdown of sugar in normal human

  4. Shekhar C Mande

    Home; Journals; Resonance – Journal of Science Education. Shekhar C Mande. Articles written in Resonance – Journal of Science Education. Volume 22 Issue 9 September 2017 pp 829-833 General Article. Nobel Prize in Physiology or Medicine 2016 · Shekhar C Mande Jyoti Rao · More Details Abstract Fulltext PDF.

  5. Fulbe mobility : migration and travel into Mande

    Bruijn, de M.E.; Dijk, van J.W.M.

    1999-01-01

    Mobility is an essential feature of the Fulbe lifestyle. This article deals with Fulbe migration into the Manden area of Mali, where they have become the neighbours of Mande populations in various qualities - as cattle herders working for Mande cultivators, as (former) rulers of Futa Jallon, as

  6. The Burning Saints

    Xygalatas, Dimitris

    . Carrying the sacred icons of the saints, participants dance over hot coals as the saint moves them. The Burning Saints presents an analysis of these rituals and the psychology behind them. Based on long-term fieldwork, The Burning Saints traces the historical development and sociocultural context......, The Burning Saints presents a highly original analysis of how mental processes can shape social and religious behaviour....

  7. The Effects of Behavioral Skills Training on Mand Training by Staff and Unprompted Vocal Mands by Children

    Nigro-Bruzzi, Darlene; Sturmey, Peter

    2010-01-01

    We evaluated the effects of a training package, including instructions, modeling, rehearsal, and feedback, for training staff members to conduct mand training with children. Experimenters collected data on staff performance on each step of a task analysis of mand training and on unprompted child vocal mands. Training resulted in increases in staff…

  8. Kinas nye mand vil korruptionen til livs

    Høyrup Christensen, Nis

    2013-01-01

    Kampen mod korruption er det første konkrete programpunkt, som Kinas nye mand i spidsen, Xi Jinping, har meldt ud. Dermed sender han et klart signal til de 80 millioner medlemmer i partiet og til den kæmpe administration, han er øverste chef for: Der skal handling til.......Kampen mod korruption er det første konkrete programpunkt, som Kinas nye mand i spidsen, Xi Jinping, har meldt ud. Dermed sender han et klart signal til de 80 millioner medlemmer i partiet og til den kæmpe administration, han er øverste chef for: Der skal handling til....

  9. Mand falder - og rejser sig igen

    Evron, Lotte Orr

    2016-01-01

    Mand falder - og rejser sig igen Anmeldelse af Lotte Evron 6 stjerner Gennem et år følger Anne Wivel med kamera og samtaler sin mangeårige ven, Per Kirkebys, vej mod en ny hverdag efter et fald. Med venskabet som ramme opbygges et usædvanligt hudløst og respektfuldt portræt af Per Kirkeby – både...

  10. Saints and Sainthood

    Bandak, Andreas

    2018-01-01

    Saints are central for personal devotion, as intercessors and mediators between humanity and God, and as models for emulation. Relationships with and images of saints and holy figures are by no means fixed, but have developed, mirrored and challenged different times and cultures. Sainthood is a p...... with him or her even if they never aspire to become a saint themselves. In this sense sainthood is a matter of social relationships—relationships which are perennially in the making....

  11. Collateral Effects of Mand Training for Children with Autism

    Plavnick, Joshua B.; Ferreri, Summer J.

    2012-01-01

    Proponents of the verbal behavior approach to instruction for individuals with autism have identified mand training as a starting point for early intervention. Mand training is a process whereby the learner is taught to request highly preferred items under conditions when those items are most valuable. A hypothesized benefit of this approach is…

  12. Hemoglobin (image)

    Hemoglobin is the most important component of red blood cells. It is composed of a protein called ... exchanged for carbon dioxide. Abnormalities of an individual's hemoglobin value can indicate defects in the normal balance ...

  13. Derived more-less relational mands in children diagnosed with autism.

    Murphy, Carol

    2009-01-01

    In Experiment 1, more and less relations were trained for arbitrary Stimuli A1 and A2 with 3 children with autism. The following conditional discriminations were then trained: A1-B1, A2-B2, B1-C1, B2-C2. In subsequent tests, participants showed derived more-less mands (mand with C1 for more and mand with C2 for less). A training procedure reversed the B-C conditional discriminations, and participants then showed derived reversed more-less mands (mand with C1 for less, C2 for more). Baseline B-C relations were retrained, and participants subsequently demonstrated a return to the original derived manding. A second experiment with 1 prior participant and 1 naive participant removed a possible confounding effect. Establishing derived manding may be an advantageous component when teaching a mand repertoire in applied settings.

  14. A Preliminary Procedure for Teaching Children with Autism to Mand for Social Information.

    Shillingsburg, M Alice; Frampton, Sarah E; Wymer, Sarah C; Bartlett, Brittany

    2018-03-01

    We used procedures established within the mands for information literature to teach two children with autism to mand for social information. Establishing operation trials were alternated with abolishing operation trials to verify the function of the responses as mands. Use of the acquired information was evaluated by examining responding to questions about their social partner. Both participants acquired mands for social information and showed generalization to novel social partners.

  15. Fish hemoglobins

    Souza,P.C. de; Bonilla-Rodriguez,G.O.

    2007-01-01

    Vertebrate hemoglobin, contained in erythrocytes, is a globular protein with a quaternary structure composed of 4 globin chains (2 alpha and 2 beta) and a prosthetic group named heme bound to each one. Having myoglobin as an ancestor, hemoglobin acquired the capacity to respond to chemical stimuli that modulate its function according to tissue requirements for oxygen. Fish are generally submitted to spatial and temporal O2 variations and have developed anatomical, physiological and biochemica...

  16. El reemplazo de mandíbulas en Eunicida

    Paxton, Hannelore

    2006-01-01

    El presente trabajo describe el reemplazo de las mandíbulas maxilares adultas en Diopatra aciculata. Este proceso es similar a la muda en artrópodos, iniciándose con la apólisis o retracción de las células de la epidermis desde la superficie interna de la antigua cutícula, para luego formar una nueva cutícula. El resultado es la formación de una mandíbula nueva bajo la mandíbula antigua. La écdisis o muda de la vieja cutícula se lleva a cabo sin quebrantamiento o daño alguno, según se e...

  17. Establishing five derived mands in three adolescent boys with autism.

    Murphy, Carol

    2010-01-01

    Three 14-year-old boys with diagnoses of autism learned to mand for the delivery or removal of tokens by presenting nonsense syllables (A(1-5), respectively). A match-to-sample procedure was used to establish conditional discriminations between the 5 A stimuli and 5 B stimuli and between the B stimuli and 5 C stimuli. Subsequently, each participant was able to use the C stimuli to mand, illustrating a transfer of function, although 1 participant first required multiple-exemplar training.

  18. Fish hemoglobins

    P.C. de Souza

    2007-06-01

    Full Text Available Vertebrate hemoglobin, contained in erythrocytes, is a globular protein with a quaternary structure composed of 4 globin chains (2 alpha and 2 beta and a prosthetic group named heme bound to each one. Having myoglobin as an ancestor, hemoglobin acquired the capacity to respond to chemical stimuli that modulate its function according to tissue requirements for oxygen. Fish are generally submitted to spatial and temporal O2 variations and have developed anatomical, physiological and biochemical strategies to adapt to the changing environmental gas availability. Structurally, most fish hemoglobins are tetrameric; however, those from some species such as lamprey and hagfish dissociate, being monomeric when oxygenated and oligomeric when deoxygenated. Fish blood frequently possesses several hemoglobins; the primary origin of this finding lies in the polymorphism that occurs in the globin loci, an aspect that may occasionally confer advantages to its carriers or even be a harmless evolutionary remnant. On the other hand, the functional properties exhibit different behaviors, ranging from a total absence of responses to allosteric regulation to drastic ones, such as the Root effect.

  19. Using Textual Prompts to Teach Mands for Information Using "Who?"

    Shillingsburg, M. Alice; Gayman, Cassondra M.; Walton, William

    2016-01-01

    Recent research on teaching mands for information to children with language deficits has focused on manipulating establishing operations (EOs). However, only a few of those studies have programmed both EO conditions (in which information is needed) and abolishing operation (AO) conditions (in which information has already been provided) to ensure…

  20. Saint Lucia revisited.

    Bos, R; Février, M; Knudsen, A B

    1988-10-01

    The eastern Caribbean island of Saint Lucia is now famous in parasitological history as the setting for a major programme of schistosomiasis control'. Perhaps less well-known are the island's effective control of many intestinal parasites, and elimination of malaria, such that the current patterns of mortality and other demographic indicators now resemble those of industrialized countries. More recently, the island has become the focus for another community-based health programme as the Caribbean region again comes to grips with Aedes aegypti and its recently imported relative, Aedes albopictus, important vectors of yellow fever and dengue viruses (see Box 1).

  1. Hemoglobin C disease

    Clinical hemoglobin C ... Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is ... Americans. You are more likely to have hemoglobin C disease if someone in your family has had ...

  2. SUFI SAINTS IN KARNATAKA

    Maruti KAMBLE

    2011-01-01

    Full Text Available Karnataka is one of the most important southern states of India. It has gainedprominence politically, socio-economically, philosophically and in many otherways. It is a meeting place of many religious philosophies and a melting pointhelping to achieve the synthesis of the teaching ofmany religious reforms. Sufismis a mystic religion. It is an offshoot of Islam. Sufi saints are the followers ofALLAH and the practice of peace, benevolence and tolerance. They promulgateda religion based on the concept of love, the love with the fellow being and thelove with the ultimate or the creator. Sufi saintsand Sufism are an existing realityin Indian socio-religious fold and it has contributed for a healthy and amicablesocial order. It has lead to a new social set-up full of values, and discipline.Sufism as a religion of the teaming millions becamethe practicing system amongthe people of India as well as Karnataka. This study of Sufi Saints in Karnataka isthus an inspired attempt to portray this religion of the soul and heart. Muchemphasis is laid on the concepts and special aspects of Sufism, along with variouspractices found in it. I was always attracted by its spiritual significance andpractical essence and also its profound influence on the general public. Hence, mylittle attempt to explain the same through the lifestories of some of the great Sufisaints in Karnataka.

  3. Emergence of tacts following mand training in young children with autism.

    Egan, Claire E

    2009-01-01

    This study sought to examine the effects of training mands on the emergence of tacts with the same response forms. Results indicated that training adjective sets as mands resulted in the emergence of adjective sets as tacts under modified, but not standard, antecedent conditions. The findings suggested that the apparent functional independence of mands and tacts may be explained by a lack of appropriate antecedent control over responding.

  4. The Functional Independence of Mands and Tacts: Has It Been Demonstrated Empirically?

    Gamba, Jonas; Goyos, Celso; Petursdottir, Anna Ingeborg

    2015-01-01

    Recently, there has been a proliferation of research on the functional independence of two of Skinner's (1957) verbal operants, the mand, and the tact. This research has produced highly variable results. In this article, we provide a critical review of the literature on mand-tact independence, a literature that has implications for both theory and…

  5. Transferring Control of the Mand to the Motivating Operation in Children with Autism

    Sweeney-Kerwin, Emily J.; Carbone, Vincent J.; O'Brien, Leigh; Zecchin, Gina; Janecky, Marietta N.

    2007-01-01

    Few studies have made use of B. F. Skinner's (1957) behavioral analysis of language and precise taxonomy of verbal behavior when describing the controlling variables for the mand relation. Consequently, the motivating operation (MO) has not typically been identified as an independent variable and the nature of a spontaneous mand has been…

  6. A Comparison of Vocal Mand Training Strategies for Children with Autism Spectrum Disorders

    Plavnick, Joshua B.; Vitale, Frances A.

    2016-01-01

    Based on Skinner's classification of verbal behavior, the mand is the first and most advantageous verbal operant to develop. Deficits in vocal mand repertoires are common in children with autism spectrum disorders (ASD) and can lead to decreased social interaction and increased problem behavior. The present investigation compared the effects of…

  7. Effects of PECS Phase III Application Training on Independent Mands in Young Children with Autism

    Love, Jessica June

    2013-01-01

    The purpose of this study was to examine the effects of PECS phase III application training on independent mands in young children with autism. Participants were five children with autism ranging from ages 2 to 4 years old. A multiple baseline across participants was used to evaluate acquisition of independent correct mands across baseline and…

  8. Training and Generalization of Peer-Directed Mands with Non-Vocal Children with Autism

    Kodak, Tiffany; Paden, Amber; Dickes, Nitasha

    2012-01-01

    The current investigation evaluated the effects of extinction and prompts on training and generalization of peer-directed mands for preferred items using a picture exchange communication system with 2 children diagnosed with autism. Results showed that independent mands with a peer increased during treatment for both participants, generalized to a…

  9. The Emergence of Untrained Mands and Tacts in Children with Autism

    Finn, Heather E.; Miguel, Caio F.; Ahearn, William H.

    2012-01-01

    Despite Skinner's (1957) assertion that verbal operants are initially functionally independent, recent studies have suggested that in some cases the acquisition of one verbal operant (e.g., mand) gives rise to the other (e.g., tact) without explicit training. The present study aimed to evaluate the functional independence of mands and tacts during…

  10. Saints and Sainthood around the Baltic Sea

    This collection of articles covers most of the Baltic Region with a special focus on the cult of saints in Russia, Prussia, Finland, Sweden, Denmark, Estonia and Latvia (more commonly referred to in the Middle Ages as Livonia). The articles cover a wide range of topics, for example the introduction...... of foreign (and ‘old’) saints into new regions, the creation of new local cults of saints in newly Christianized regions, the role of the cult of saints in the creation of political and lay identities, the adaption of the cult of saints in folk poetry and the potential role of saints in times of war...

  11. The influence of motivating operations on generalization probes of specific mands by children with autism.

    Fragale, Christina L; O'Reilly, Mark F; Aguilar, Jeannie; Pierce, Nigel; Lang, Russell; Sigafoos, Jeff; Lancioni, Giulio

    2012-01-01

    We investigated the influence of motivating operations on the generalization of newly taught mands across settings and communication partners for 3 children with autism. Two conditions were implemented prior to generalization probes. In the first condition, participants were given access to a preferred item until they rejected the item (i.e., abolishing operation). In the second condition, the item was not available to participants prior to generalization probes (i.e., establishing operation). The effects of these conditions on the generalization of newly taught mands were evaluated in a multielement design. Results indicated differentiated responding during generalization probes in which more manding with the target mand was observed following the presession no-access condition than in the presession access condition. These results support the consideration of motivating operations when assessing generalization of target mands to various untrained contexts.

  12. Teaching children with autism spectrum disorders to mand for the removal of stimuli that prevent access to preferred items.

    Shillingsburg, M Alice; Powell, Nicole M; Bowen, Crystal N

    2013-01-01

    Mand training is often a primary focus in early language instruction and typically includes mands that are positively reinforced. However, mands maintained by negative reinforcement are also important skills to teach. These include mands to escape aversive demands or unwanted items. Another type of negatively reinforced mand important to teach involves the removal of a stimulus that prevents access to a preferred activity. We taught 5 participants diagnosed with autism spectrum disorders to mand for the removal of a stimulus in order to access a preferred item that had been blocked. An evaluation was conducted to determine if participants responded differentially when the establishing operations for the preferred item were present versus absent. All participants learned to mand for the removal of the stimulus exclusively under conditions when the establishing operation was present.

  13. Two African Saints in Medieval Germany.

    Grimm, Reinhold

    1992-01-01

    The origin and development of two African saints are discussed: Saint Maurice, patron saint of the eastern empire of Otto I; and Caspar, the youngest of the three Magi. Their representation in German art is described and illustrated. (Author/LB)

  14. The features of Saint Louis

    Pierre-Yves Le Pogam

    2017-12-01

    Full Text Available The recent ninth centenary of the birth of Saint Louis, in 2014, gave the possibility to renew the study of the man and his reign, so important for French history, not in a nationalistic agenda or for a mere celebration, but in order to shed new light on a figure indeed profoundly studied but deserving a repeated attention, so much Louis IX lends to many-sided, even contradictory explanations. In the past, one has paid an almost maniacal attention to the point of the physical appearance of the king, looking in some images for a reflection of, or indeed a portrait of Saint Louis. Or, on the contrary and more recently, one has denied any validity to this trend of studies. In line with the essay I devoted on this question in the catalogue of the recent exhibition on Saint Louis in Paris, I would like here to go further in the analysis, especially regarding the meaning of details of the dress and bodily features of the saint king.

  15. Mands for Information Using "How" Under EO-Absent and EO-Present Conditions.

    Shillingsburg, M Alice; Bowen, Crystal N; Valentino, Amber L

    2014-06-01

    The present study replicates and extends previous research on teaching "How?" mands for information to children with autism. The experimental preparation involved mand training in the context of completing preferred activities and included training and testing under conditions when the establishing operation (EO) was present and absent. Results show that two children with autism acquired mands for information using How? only in situations where information was valuable (i.e., the EO was present); they then consistently made use of the information provided in activity completion. Generalization to novel, untaught situations was assessed.

  16. Église Saint-Pierre-Saint-Paul, Appoigny (Yonne

    Fabrice Henrion

    2009-09-01

    Full Text Available L’église Saint-Pierre-Saint-Paul d’Appoigny témoigne d’un important chantier du début du XIIIe siècle , mais les sources permettent d’envisager la présence d’un sanctuaire au moins depuis l’extrême fin du VIe siècle. En effet, le règlement liturgique établit par Aunaire, évêque d’Auxerre de 561 à 604, mentionne Epponiacus dans la liste des sanctuaires auxerrois, sans que le vocable de l’église d’Appoigny ne soit précisé. Par ailleurs, depuis au moins le IXe siècle, une tradition, reprise par ...

  17. Assessing Mand Topography Preference When Developing a Functional Communication Training Intervention.

    Kunnavatana, S Shanun; Wolfe, Katie; Aguilar, Alexandra N

    2018-05-01

    Functional communication training (FCT) is a common function-based behavioral intervention used to decrease problem behavior by teaching an alternative communication response. Therapists often arbitrarily select the topography of the alternative response, which may influence long-term effectiveness of the intervention. Assessing individual mand topography preference may increase treatment effectiveness and promote self-determination in the development of interventions. This study sought to reduce arbitrary selection of FCT mand topography by determining preference during response training and acquisition for two adults with autism who had no functional communication skills. Both participants demonstrated a clear preference for one mand topography during choice probes, and the preferred topography was then reinforced during FCT to reduce problem behavior and increase independent communication. The implications of the results for future research on mand selection during FCT are discussed.

  18. Mands for information using "who?" and "which?" in the presence of establishing and abolishing operations.

    Shillingsburg, M Alice; Bowen, Crystal N; Valentino, Amber L; Pierce, Laura E

    2014-01-01

    Treatments designed to teach mands for information have included prompting and differential reinforcement, as well as procedures to manipulate the relevant establishing operation (EO). However, previous studies have not included relevant abolishing operation (AO) conditions to ensure that the mand is under relevant antecedent control. Data on listener responses (i.e., use of the information) are also absent in the literature. The current study shows differential responding under EO and AO conditions and reports listener responses that demonstrate use of the provided information. Three participants, diagnosed with an autism spectrum disorder, learned to mand for information using "who?" and "which?" questions exclusively under EO conditions. In addition, each participant responded to the information provided to access a preferred item. Generalization of the "which?" mand for information was also demonstrated across novel stimuli. © Society for the Experimental Analysis of Behavior.

  19. Derived Manding in Children with Autism: Synthesizing Skinner's Verbal Behavior with Relational Frame Theory

    Murphy, Carol; Barnes-Holmes, Dermot; Barnes-Holmes, Yvonne

    2005-01-01

    Mand functions for two stimuli (A1 and A2) were trained for 3 children with autism and were then incorporated into two related conditional discriminations (A1-B1/A2 -B2 and B1-C1/B2-C2). Tests were conducted to probe for a derived transfer of mand response functions from Al and A2 to C1 and C2, respectively. When 1 participant failed to…

  20. EAARL-B Submerged Topography - Saint Croix and Saint Thomas, U.S. Virgin Islands, 2014

    National Oceanic and Atmospheric Administration, Department of Commerce — Binary point-cloud data for part of the submerged environs of Saint Croix and Saint Thomas, U.S. Virgin Islands, were produced from remotely sensed, geographically...

  1. The Hemoglobin E Thalassemias

    Fucharoen, Suthat; Weatherall, David J.

    2012-01-01

    Hemoglobin E (HbE) is an extremely common structural hemoglobin variant that occurs at high frequencies throughout many Asian countries. It is a β-hemoglobin variant, which is produced at a slightly reduced rate and hence has the phenotype of a mild form of β thalassemia. Its interactions with different forms of α thalassemia result in a wide variety of clinical disorders, whereas its coinheritance with β thalassemia, a condition called hemoglobin E β thalassemia, is by far the most common severe form of β thalassemia in Asia and, globally, comprises approximately 50% of the clinically severe β-thalassemia disorders. PMID:22908199

  2. African Journals Online: Saint Kitts and Nevis

    African Journals Online: Saint Kitts and Nevis. Home > African Journals Online: Saint Kitts and Nevis. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Browse By Category · Browse Alphabetically · Browse By Country · List All Titles · Free to read Titles This Journal is ...

  3. A "Sacra Rappresentazione" of Saint Apollonia's Martyrdom.

    Eramo, Stefano; Natali, Alessio; Bravi, Monia; Cella, Diana; Milia, Egle

    The literary sources of Saint Apollonia's martyrdom and the evolution of Medieval and Renaissance religious drama are presented along with the compendium of a "Sacra Rappresentazione" from Italian Renaissance regarding Saint Apollonia's Martyrdom. Copyright American Academy of the History of Dentistry.

  4. The sacred disease and its patron saint.

    Fatović-Ferencić, S; Dürrigl, M A

    2001-08-01

    Although the Hippocratic natural theory of epilepsy as a brain disorder originated around 400 bc , it did not begin to take root until the 18th and 19th centuries, leaving the intervening centuries dominated by mostly supernatural concepts. This article provides historical insight into human behavior when afflicted with disease: supplication to a patron saint, Saint Valentine, a cult that spread throughout Europe.

  5. MANIPULATION OF MOTIVATING OPERATIONS AND USE OF A SCRIPT-FADING PROCEDURE TO TEACH MANDS FOR LOCATION TO CHILDREN WITH LANGUAGE DELAYS

    Howlett, Melissa A; Sidener, Tina M; Progar, Patrick R; Sidener, David W

    2011-01-01

    The effects of contriving motivating operations (MOs) and script fading on the acquisition of the mand “Where's [object]?” were evaluated in 2 boys with language delays. During each session, trials were alternated in which high-preference items were present (abolishing operation [AO] trials) or missing (establishing operation [EO] trials) from their typical locations. Both participants learned to mand during EO trials and not to mand during AO trials during training. Generalization of manding...

  6. Assessing the acquisition and generalization of two mand forms with adults with severe developmental disabilities.

    Chambers, Mark; Rehfeldt, Ruth Anne

    2003-01-01

    The purpose of this study was to determine whether manual sign or the Picture Exchange Communication System (P.E.C.S.) (Frost and Bondy, 1994) would be more effective in teaching mand skills to adults with mental retardation in the severe and profound range. Four participants were taught to mand for four reinforcing items using both communication modalities, in an alternating treatments design. Three of four participants demonstrated criterion performance across all four mands using P.E.C.S. first. Two of those three participants later demonstrated criterion performance for the mands using manual sign. The fourth participant was removed from the study during training due to illness, but her progress indicated greater acquisition with P.E.C.S. Generalization probes conducted at participants' respective residences showed that three participants demonstrated generalization across settings using P.E.C.S., and two participants demonstrated generalization across settings using manual sign. Participants were also more likely to mand for reinforcing items not present using P.E.C.S. than using manual sign.

  7. Teaching Children with Autism to Engage in Peer-Directed Mands Using a Picture Exchange Communication System

    Paden, Amber R.; Kodak, Tiffany; Fisher, Wayne W.; Gawley-Bullington, Elizabeth M.; Bouxsein, Kelly J.

    2012-01-01

    We evaluated differential reinforcement of alternative behavior (DRA) plus prompting to increase peer-directed mands for preferred items using a picture exchange communication system (PECS). Two nonvocal individuals with autism participated. Independent mands with a peer increased with the implementation of DRA plus prompting for both…

  8. Mand træn din bækkenbund og få bedre rejsning

    Ravnkilde Marlet, Laila; Gerbild, Helle Nygaard

    2016-01-01

    Har du (eller din mand) problemer med at holde på urin eller at opnå eller bevare rejsningen, er der god grund til at søge hjælp. Der findes nemlig effektive og billige behandlingsmuligheder.......Har du (eller din mand) problemer med at holde på urin eller at opnå eller bevare rejsningen, er der god grund til at søge hjælp. Der findes nemlig effektive og billige behandlingsmuligheder....

  9. El conducto de Serres: alta prevalencia en mandíbulas infantiles

    Hernández Huaripaucar, Edgar; Hernández, Liliana Gisela

    2011-01-01

    Objetivo. Conocer algunas características anátomo-topográficas del conducto de Serres y su prevalencia en mandíbulas infantiles, adultas y seniles. Material y método. La muestra estuvo constituida por 45 mandíbulas infantiles, adultas y seniles que presentaron o no el conducto de Serres, provenientes del anfiteatro de Anatomía de la Facultad de Odontología de la Universidad San Luís Gonzaga de Ica. La hipótesis operativa plantea que las características del conducto de Serres estudiad...

  10. 75 FR 38718 - Safety Zone; Sault Sainte Marie 4th of July Fireworks, St. Mary's River, Sault Sainte Marie, MI

    2010-07-06

    ... temporary safety zone on the St. Mary's River, Sault Sainte Marie, Michigan. This zone is intended to..., St. Mary's River, Sault Sainte Marie, MI (a) Location. The following area is a temporary safety zone...-AA00 Safety Zone; Sault Sainte Marie 4th of July Fireworks, St. Mary's River, Sault Sainte Marie, MI...

  11. REPRESENTATION OF THE SAINTS IN ORTHODOX ICONOGRAPHY

    Veronica GHEORGHIȚĂ

    2014-06-01

    Full Text Available In Romanian iconography, the icon is described as an image of truth, expressing, strengthening and teaching the truth of orthodox faith. Adept and guardian of the byzantine style, the icon depicts the saints in their divine and human nature, but has traits that show the holiness, perfection and simplicity of their life. Given that the saints have been seen as modest, abstinent, fasting people, they have never been portrayed as overweight, but thin, with hollow cheeks and a frail physical appearance. In fact, the iconographic representations are characterized by a high ability to summarize the reality, the physical appearance of the saints being non-anatomical, disproportionate. Lately, it has been noticed in certain iconographic representations a change in painting style: to reproduce reality as faithfully as possible. The orientation toward the icon's external beauty involved the redefinition of the iconic portrait of the saints, who are depicted as human as possible.

  12. Phylogeny of Echinoderm Hemoglobins.

    Ana B Christensen

    Full Text Available Recent genomic information has revealed that neuroglobin and cytoglobin are the two principal lineages of vertebrate hemoglobins, with the latter encompassing the familiar myoglobin and α-globin/β-globin tetramer hemoglobin, and several minor groups. In contrast, very little is known about hemoglobins in echinoderms, a phylum of exclusively marine organisms closely related to vertebrates, beyond the presence of coelomic hemoglobins in sea cucumbers and brittle stars. We identified about 50 hemoglobins in sea urchin, starfish and sea cucumber genomes and transcriptomes, and used Bayesian inference to carry out a molecular phylogenetic analysis of their relationship to vertebrate sequences, specifically, to assess the hypothesis that the neuroglobin and cytoglobin lineages are also present in echinoderms.The genome of the sea urchin Strongylocentrotus purpuratus encodes several hemoglobins, including a unique chimeric 14-domain globin, 2 androglobin isoforms and a unique single androglobin domain protein. Other strongylocentrotid genomes appear to have similar repertoires of globin genes. We carried out molecular phylogenetic analyses of 52 hemoglobins identified in sea urchin, brittle star and sea cucumber genomes and transcriptomes, using different multiple sequence alignment methods coupled with Bayesian and maximum likelihood approaches. The results demonstrate that there are two major globin lineages in echinoderms, which are related to the vertebrate neuroglobin and cytoglobin lineages. Furthermore, the brittle star and sea cucumber coelomic hemoglobins appear to have evolved independently from the cytoglobin lineage, similar to the evolution of erythroid oxygen binding globins in cyclostomes and vertebrates.The presence of echinoderm globins related to the vertebrate neuroglobin and cytoglobin lineages suggests that the split between neuroglobins and cytoglobins occurred in the deuterostome ancestor shared by echinoderms and vertebrates.

  13. Mand falder – og rejser sig igen på Faldnørden

    Evron, Lotte Orr

    2017-01-01

    Denne blogpost indeholder en filmanmeldelse af Anne Wivels bevægende film: Mand falder, om multikunstneren Per Kirkebys fald og tilbagevenden til kunsten og livet. Filmen gjorde stort indtryk på mig og viser det eksistentielle perspektiv i forbindelse med et fatalt fald meget konkret. Anmeldelsen...

  14. The Effects of Parent-Implemented PECS Training on Improvisation of Mands by Children with Autism

    Chaabane, Delia B. Ben; Alber-Morgan, Sheila R.; DeBar, Ruth M.

    2009-01-01

    The present study examined the extent to which mothers were able to train their children, 2 boys with autism, to exchange novel pictures to request items using the picture exchange communication system (PECS). Generalization probes assessing each child's ability to mand for untrained items were conducted throughout conditions. Using a multiple…

  15. Establishing Derived Manding for Specific Amounts with Three Children: An Attempt at Synthesizing Skinner's "Verbal Behavior" with Relational Frame Theory

    Murphy, Carol; Barnes-Holmes, Dermot

    2009-01-01

    Participants were 2 typically developing children, aged 9 and 10 years, and 1 child, aged 4 years, with a reported severe speech delay. Five specific mand functions were trained such that participants learned to mand for the delivery or removal of tokens to the value of -2, -1, 0, +1, and +2, by presenting an arbitrary stimulus (A1, A2, A3, A4,…

  16. Saint Benedict of Palermo in Spain

    Bernard VINCENT

    2016-06-01

    Full Text Available Among the devotions to the black Saints, the one of which Benedict of Palermo was the object in Spain in the 17th and 18th centuries was the most remarkable. Born near Palermo to African slaves, this lay brother of a Sicilian franciscan convent, died in the odor of sanctity in 1589. His immediate popularity, encouraged both by the Church and by the Hispanic monarchy, was considerable within the communities of slaves and free blacks. Benedict was beatified in 1743, event which was followed by numerous celebrations and his eventual canonization in 1807. The fervour which surrounded him fade gradually because of the competition represented by the devotion to other black saints and by the very visible decline of slavery. However, thanks to the efforts of the franciscan order, the worship of Saint Benoît of Palermo continued until our days, particularly in Galicia.

  17. Rice (Oryza) hemoglobins

    Hemoglobins (Hbs) corresponding to non-symbiotic (nsHb) and truncated (tHb) Hbs have been identified in rice (Oryza). This review discusses the major findings from the current studies on rice Hbs. At the molecular level, a family of the nshb genes, consisting of hb1, hb2, hb3, hb4 and hb5, and a sin...

  18. THE INFLUENCE OF MOTIVATING OPERATIONS ON GENERALIZATION PROBES OF SPECIFIC MANDS BY CHILDREN WITH AUTISM

    Fragale, Christina L; O'Reilly, Mark F; Aguilar, Jeannie; Pierce, Nigel; Lang, Russell; Sigafoos, Jeff; Lancioni, Giulio

    2012-01-01

    We investigated the influence of motivating operations on the generalization of newly taught mands across settings and communication partners for 3 children with autism. Two conditions were implemented prior to generalization probes. In the first condition, participants were given access to a preferred item until they rejected the item (i.e., abolishing operation). In the second condition, the item was not available to participants prior to generalization probes (i.e., establishing operation)...

  19. St. René: the Patron Saint of Anaesthetists and a Patron Saint of Canada.

    Calverley, R K

    1980-01-01

    René Goupil, the Patron Saint of Anaesthetists, and a Patron Saint of Canada, was born in Angers, France in 1608 and studied surgery. He joined the Jesuits as a donné or volunteer worker in 1640 and served in the then tiny colony of Quebec as one of the first medical workers of Canada. After earning meritorious praise for his skills, he again volunteered to attend the Hurons at Sainte Marie, a mission far beyond the frontiers. René's canoe party was ambushed. He was captured by the Mohawks and endured eight weeks of cruel torture before being killed on September 29, 1642. René was the first of eight North American martyrs whose dedication was recognized by canonization in 1930. St. René was appointed Patron Saint of Anaesthetists in 1951.

  20. President Ilves kõneles Saint Gallenis

    2009-01-01

    President Toomas Hendrik Ilves esines 9. mail 2009 Šveitsis, Saint Galleni 39. majandus- ja poliitikasümpoosionil kõnega teemal "20 aastat pärast Berliini müüri langemist - Euroopa uued väljakutsed". Vabariigi President töövisiidil Šveitsis 08.-09.05.2009

  1. Of volcanoes, saints, trash, and frogs

    Andersen, Astrid Oberborbeck

    , at the same time as political elections and economic hardship. During one year of ethnographic fieldwork volcanoes, saints, trash and frogs were among the nonhuman entities referred to in conversations and engaged with when responding to the changes that trouble the world and everyday life of Arequipans...

  2. Saint: a lightweight integration environment for model annotation.

    Lister, Allyson L; Pocock, Matthew; Taschuk, Morgan; Wipat, Anil

    2009-11-15

    Saint is a web application which provides a lightweight annotation integration environment for quantitative biological models. The system enables modellers to rapidly mark up models with biological information derived from a range of data sources. Saint is freely available for use on the web at http://www.cisban.ac.uk/saint. The web application is implemented in Google Web Toolkit and Tomcat, with all major browsers supported. The Java source code is freely available for download at http://saint-annotate.sourceforge.net. The Saint web server requires an installation of libSBML and has been tested on Linux (32-bit Ubuntu 8.10 and 9.04).

  3. Investigating the Acquisition, Generalization, and Emergence of Untrained Verbal Operants for Mands Acquired Using the Picture Exchange Communication System in Adults with Severe Developmental Disabilities

    Ziomek, M. M.; Rehfeldt, R. A.

    2008-01-01

    This study compared the total amount of training time and total number of trial blocks for individuals with severe developmental disabilities to acquire mands under control of unconditioned establishing operations and mands under control of transitive conditioned establishing operations for manual sign and for the Picture Exchange Communication…

  4. The effects of parent-implemented PECS training on improvisation of mands by children with autism.

    Ben Chaabane, Delia B; Alber-Morgan, Sheila R; DeBar, Ruth M

    2009-01-01

    The present study examined the extent to which mothers were able to train their children, 2 boys with autism, to exchange novel pictures to request items using the picture exchange communication system (PECS). Generalization probes assessing each child's ability to mand for untrained items were conducted throughout conditions. Using a multiple baseline design, results demonstrated that both children improvised by using alternative symbols when the corresponding symbol was unavailable across all symbol categories (colors, shapes, and functions) and that parents can teach their children to use novel pictorial response forms.

  5. The results of virological surveillance for intrauterine infections in Saint-Petersburg

    E. A. Murina

    2014-01-01

    Full Text Available The purpose of researchis the determiningthe etiological structure ofintrauterine infections in Saint-Petersburg pediatric patients, pregnant women andinfants born to them using a variety of virological methods.Methods: serum from 164 children aged from 1 month to 14 years with diagnosis of «intrauterine infection». Serum from 80 pregnant women, collected in each trimester (total – 240 samples, their 42 children (at the age of 1–2 and 4–6  months of life, total – 82 samples. Immunoglobulin Mand G (IgM and IgGto herpes virus type 1, cytomegalovirus (CMV, Toxoplasma gondii, mycoplasma and chlamydia, rubella, Epstein-Barr virus (EBV and parvovirus B19, as well as IgG avidity,were determined by ELISA in all these samples. Theimmunoblot (Western blot, using the «Immunoblot2000» with test kits from «Euroimmun AG» (Germany, was applied to confirm cases. Statistical analysis wasperformed with theprograms Microsoft Excel, Statistica6.Results: cytomegalovirus, herpes virus 1st type and Epstein-Barr virus infections are dominate in the structure of intrauterine ones (45%, 23% and 14%, respectively. Laboratory evidence ofreactivationof cytomegalovirus (35% ofpregnant womenin the 2nd and/or 3rd trimesters and acuteparvovirus infection (15% of cases were found. Specific IgM to cytomegalovirus were detected in 6,2% ofchildren in the firstsix months of life.Conclusions: with the aim of early detection of cytomegalovirus reactivation and acute parvovirus infection it isnecessary to monitor pregnant women with the definition of specific IgM, IgG and avidity IgG. The procedure to using immunoblotting in the diagnosis of intrauterine infectionsneeds to be further study.

  6. Saint rulers as a category of sanctity in Orthodoxy

    Jarosław Charkiewicz

    2015-01-01

    In the wide spectre of Orthodox human sanctity, among others, there is also a category of saint rulers. Despite the fact that it’s represented by a significant number of saints, it remains, utterly undeservedly, in the shadow of the others – more known or more deeply rooted historically. On top of that, the situation may result as well from the fact that saint rulers, as a distinct category of saint, are not separately mentioned neither during the proskomedia, nor during the intercessory pray...

  7. The effects of mands and models on the speech of unresponsive language-delayed preschool children.

    Warren, S F; McQuarter, R J; Rogers-Warren, A K

    1984-02-01

    The effects of the systematic use of mands (non-yes/no questions and instructions to verbalize), models (imitative prompts), and specific consequent events on the productive verbal behavior of three unresponsive, socially isolate, language-delayed preschool children were investigated in a multiple-baseline design within a classroom free play period. Following a lengthy intervention condition, experimental procedures were systematically faded out to check for maintenance effects. The treatment resulted in increases in total verbalizations and nonobligatory speech (initiations) by the subjects. Subjects also became more responsive in obligatory speech situations. In a second free play (generalization) setting, increased rates of total child verbalizations and nonobligatory verbalizations were observed for all three subjects, and two of the three subjects were more responsive compared to their baselines in the first free play setting. Rate of total teacher verbalizations and questions were also higher in this setting. Maintenance of the treatment effects was shown during the fading condition in the intervention setting. The subjects' MLUs (mean length of utterance) increased during the intervention condition when the teacher began prompting a minimum of two-word utterances in response to a mand or model.

  8. Gateway to the Syriac Saints: A Database Project

    Jeanne-Nicole Mellon Saint-Laurent

    2016-04-01

    Full Text Available This article describes The Gateway to the Syriac Saints, a database project developed by the Syriac Reference Portal (www.syriaca.org. It is a research tool for the study of Syriac saints and hagiographic texts. The Gateway to the Syriac Saints is a two-volume database: 1 Qadishe and 2 Bibliotheca Hagiographica Syriaca Electronica (BHSE. Hagiography, the lives of the saints, is a multiform genre. It contains elements of myth, history, biblical exegesis, romance, and theology. The production of saints’ lives blossomed in late antiquity alongside the growth of the cult of the saints. Scholars have attended to hagiographic traditions in Greek and Latin, but many scholars have yet to discover the richness of Syriac hagiographic literature: the stories, homilies, and hymns on the saints that Christians of the Middle East told and preserved. It is our hope that our database will give scholars and students increased access to these traditions to generate new scholarship. The first volume, Qadishe or “saints” in Syriac, is a digital catalogue of saints or holy persons venerated in the Syriac tradition. Some saints are native to the Syriac-speaking milieu, whereas others come from other linguistic or cultural traditions. Through the translation of their hagiographies and the diffusion of saints’ cults in the late antique world, saints were adopted, “imported,” and appropriated into Syriac religious memory. The second volume, the BHSE, focuses on Syriac hagiographic texts. The BHSE contains the titles of over 1000 Syriac stories, hymns, and homilies on saints. It also includes authors’ or hagiographers’ names, the first and last lines of the texts (in Syriac, English, and French, bibliographic information, and the names of the manuscripts containing these hagiographic works. We have also listed modern and ancient translations of these works. All of the data in the Gateway to the Syriac Saints has been encoded in TEI, and it is fully

  9. Acquisition of Picture Exchange-Based vs. Signed Mands and Implications to Teach Functional Communication Skills to Children with Autism

    Nam, Sang S.; Hwang, Young S.

    2016-01-01

    A literature review was conducted to describe important concepts involved in functional analysis of verbal behavior as well as to evaluate empirical research findings on acquisition of picture exchange-based vs. signed mands to suggest instructional implications for teachers and therapists to teach functional communication skills to children with…

  10. The Picture Exchange Communication System: Effects on Manding and Speech Development for School-Aged Children with Autism

    Tincani, Matt; Crozier, Shannon; Alazett, Shannon

    2006-01-01

    We examined the effects of the Picture Exchange Communication System (PECS; Frost & Bondy, 2002) on the manding (requesting) and speech development of school-aged children with autism. In study 1, two participants, Damian and Bob, were taught PECS within a delayed multiple baseline design. Both participants demonstrated increased levels of manding…

  11. René Goupil: patron saint of anesthetists.

    Quintal, J

    1995-06-01

    René Goupil, the patron saint of anesthetists, is addressed mainly as a 17th century French surgeon who practiced his art in North America. He is also presented as a Jesuit martyr and saint. The article freely borrows from past writings of Jesuits on René Goupil.

  12. the vision of divine light in saint gregory palamas's theology

    in Romania. 2. THE RECEPTION OF SAINT GREGORY PALAMAS'S. THEOLOGY IN THE WEST. In the West, the reception of Saint Gregory Palamas's theology, as it is known, was rather a negative one. His doctrine of divine light was rejected, because it postulated the possibility of seeing God with corporeal eyes. (Lossky ...

  13. Locality and Distance in Cults of Saints in Medieval Norway

    Petersen, Nils Holger

    2017-01-01

    A discussion of the Norwegian medieval cult of the purported Irish St Sunniva, a cult in which holiness is seen as foreign and distant in the cultural memory of the saint.......A discussion of the Norwegian medieval cult of the purported Irish St Sunniva, a cult in which holiness is seen as foreign and distant in the cultural memory of the saint....

  14. Non-invasive hemoglobin monitoring.

    Joseph, Bellal; Haider, Ansab; Rhee, Peter

    2016-09-01

    Technology has transformed the practice of medicine and surgery in particular over the last several decades. This change in practice has allowed diagnostic and therapeutic tests to be performed less invasively. Hemoglobin monitoring remains one of the most commonly performed diagnostic tests in the United States. Recently, non-invasive hemoglobin monitoring technology has gained popularity. The aim of this article is to review the principles of how this technology works, pros and cons, and the implications of non-invasive hemoglobin technology particularly in trauma surgery. Copyright © 2015 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

  15. Making midwives: postmodern conditions and midwifery training in Saint Lucia.

    Hsu, C

    2001-01-01

    Drawing on material from fieldwork conducted on the island of Saint Lucia, I examine how Saint Lucian nurse-midwives and student midwives negotiate multiple ways of understanding and evaluating their practices and roles in light of contradictory and powerful cultural, historical, and political forces. I argue that, although Saint Lucian nurse-midwives may not qualify as "postmodern" according to the criteria proposed by Davis-Floyd and Davis (1996), they are nonetheless struggling with postmodern conditions as they negotiate between competing healing ideologies. I illustrate the significance of these negotiations through analyzing: (1) the ways nurse-midwives understand and articulate the healing ideologies at play in Saint Lucia, (2) historical and ideological aspects of the Saint Lucian nurse-midwifery training program, and (3) a classroom discussion during which student reported on "bush-midwives."

  16. Nonlinear photoacoustic spectroscopy of hemoglobin.

    Danielli, Amos; Maslov, Konstantin; Favazza, Christopher P; Xia, Jun; Wang, Lihong V

    2015-05-18

    As light intensity increases in photoacoustic imaging, the saturation of optical absorption and the temperature dependence of the thermal expansion coefficient result in a measurable nonlinear dependence of the photoacoustic (PA) signal on the excitation pulse fluence. Here, under controlled conditions, we investigate the intensity-dependent photoacoustic signals from oxygenated and deoxygenated hemoglobin at varied optical wavelengths and molecular concentrations. The wavelength and concentration dependencies of the nonlinear PA spectrum are found to be significantly greater in oxygenated hemoglobin than in deoxygenated hemoglobin. These effects are further influenced by the hemoglobin concentration. These nonlinear phenomena provide insights into applications of photoacoustics, such as measurements of average inter-molecular distances on a nm scale or with a tuned selection of wavelengths, a more accurate quantitative PA tomography.

  17. Nonlinear photoacoustic spectroscopy of hemoglobin

    Danielli, Amos; Maslov, Konstantin; Favazza, Christopher P.; Xia, Jun; Wang, Lihong V.

    2015-01-01

    As light intensity increases in photoacoustic imaging, the saturation of optical absorption and the temperature dependence of the thermal expansion coefficient result in a measurable nonlinear dependence of the photoacoustic (PA) signal on the excitation pulse fluence. Here, under controlled conditions, we investigate the intensity-dependent photoacoustic signals from oxygenated and deoxygenated hemoglobin at varied optical wavelengths and molecular concentrations. The wavelength and concentration dependencies of the nonlinear PA spectrum are found to be significantly greater in oxygenated hemoglobin than in deoxygenated hemoglobin. These effects are further influenced by the hemoglobin concentration. These nonlinear phenomena provide insights into applications of photoacoustics, such as measurements of average inter-molecular distances on a nm scale or with a tuned selection of wavelengths, a more accurate quantitative PA tomography

  18. Nonlinear photoacoustic spectroscopy of hemoglobin

    Danielli, Amos; Maslov, Konstantin; Favazza, Christopher P.; Xia, Jun; Wang, Lihong V., E-mail: LHWANG@WUSTL.EDU [Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, St. Louis, Missouri 63130 (United States)

    2015-05-18

    As light intensity increases in photoacoustic imaging, the saturation of optical absorption and the temperature dependence of the thermal expansion coefficient result in a measurable nonlinear dependence of the photoacoustic (PA) signal on the excitation pulse fluence. Here, under controlled conditions, we investigate the intensity-dependent photoacoustic signals from oxygenated and deoxygenated hemoglobin at varied optical wavelengths and molecular concentrations. The wavelength and concentration dependencies of the nonlinear PA spectrum are found to be significantly greater in oxygenated hemoglobin than in deoxygenated hemoglobin. These effects are further influenced by the hemoglobin concentration. These nonlinear phenomena provide insights into applications of photoacoustics, such as measurements of average inter-molecular distances on a nm scale or with a tuned selection of wavelengths, a more accurate quantitative PA tomography.

  19. Folkets mand

    Birkholm, Klavs; Lasch, Christopher

    2016-01-01

    Genudgivelsen på dansk af Christopher Lasch' hovedværk "The True And Only Heaven" har med rette fået den nye titel "Populismen". Det er elitens betegnelse for enhver modstand mod "deres fremskridt"...

  20. Hemoglobin C, S-C, and E Diseases

    ... quickly than others, resulting in chronic anemia. Hemoglobin C disease Hemoglobin C disease occurs mostly in blacks. ... a common complication of hemoglobin C disease. Hemoglobin S-C disease Hemoglobin S-C disease occurs in people who ...

  1. Saint rulers as a category of sanctity in Orthodoxy

    Jarosław Charkiewicz

    2015-11-01

    Full Text Available In the wide spectre of Orthodox human sanctity, among others, there is also a category of saint rulers. Despite the fact that it’s represented by a significant number of saints, it remains, utterly undeservedly, in the shadow of the others – more known or more deeply rooted historically. On top of that, the situation may result as well from the fact that saint rulers, as a distinct category of saint, are not separately mentioned neither during the proskomedia, nor during the intercessory prayer of the anaphora. Still, the saint rulers definitely should be considered a separate type of sanctity, deserving a somehow wider presentation. Such is therefore the aim of this article.It is also an attempt of suggesting an interior systematic of this category of sanctity. Preserving, appearing in science, classifications of the saint rulers, the author gives also his own proposition. In the category of saint rulers there are four following groups: (1 rulerswho weren’t neither martyrs nor monks or passion-bearers, (2 rulers who died martyrs, (3 rulers who long before their death became monks and led monastic life, (4 rulers-passion-bearers.

  2. Saint Venant's equation and theory of characteristics

    Daubert, Andre

    1978-01-01

    This theory, in its general scope, will be dealt with through the concrete example of Saint Venant's equations which govern the waves in channels. 1. Finding the characteristic directions. The aim is to interpret the hyperbolic sort of equations to show that there is a way of combining them in order to shape them so that they express a linear relation between the variations of the unknowns when moving along particular differential paths. In certain cases, this differential relation can integrate to lead to Rieman's invariants. 2. Relation between the theory of characteristics and the wave equation. In the linear systems case, it is worthwhile showing simply, how the method of characteristics is linked to the conventional treatment of the wave equation. 3. Relation between the theory of characteristics and the Cauchy problem. The theory of characteristics is frequently introduced as from the Cauchy problem, the characteristics forming the conditions of indetermination of the Cauchy problem [fr

  3. Geologic map of Saint Lawrence Island, Alaska

    Patton, William W.; Wilson, Frederic H.; Taylor, Theresa A.

    2011-01-01

    Saint Lawrence Island is located in the northern Bering Sea, 190 km southwest of the tip of the Seward Peninsula, Alaska, and 75 km southeast of the Chukotsk Peninsula, Russia (see index map, map sheet). It lies on a broad, shallow-water continental shelf that extends from western Alaska to northeastern Russia. The island is situated on a northwest-trending structural uplift exposing rocks as old as Paleozoic above sea level. The submerged shelf between the Seward Peninsula and Saint Lawrence Island is covered mainly with Cenozoic deposits (Dundo and Egiazarov, 1982). Northeast of the island, the shelf is underlain by a large structural depression, the Norton Basin, which contains as much as 6.5 km of Cenozoic strata (Grim and McManus, 1970; Fisher and others, 1982). Sparse test-well data indicate that the Cenozoic strata are underlain by Paleozoic and Proterozoic rocks, similar to those exposed on the Seward Peninsula (Turner and others, 1983). Saint Lawrence Island is 160 km long in an east-west direction and from 15 km to 55 km wide in a north-south direction. The east end of the island consists largely of a wave-cut platform, which has been elevated as much as 30 m above sea level. Isolated upland areas composed largely of granitic plutons rise as much as 550 m above the wave-cut platform. The central part of the island is dominated by the Kookooligit Mountains, a large Quaternary shield volcano that extends over an area of 850 km2 and rises to an elevation of 630 m. The west end of the island is composed of the Poovoot Range, a group of barren, rubble-covered hills as high as 450 m that extend from Boxer Bay on the southwest coast to Taphook Mountain on the north coast. The Poovoot Range is flanked on the southeast by the Putgut Plateau, a nearly flat, lake-dotted plain that stands 30?60 m above sea level. The west end of the island is marked by uplands underlain by the Sevuokuk pluton (unit Kg), a long narrow granite body that extends from Gambell on the

  4. Multiple sclerosis in Latter Day Saints (Mormons).

    Hawkes, C H; Ramkumar, N; Baker, R; Lyon, J L

    2007-04-01

    Compliant members of the Church of Jesus Christ of Latter Day Saints (LDS, Mormons) have a low incidence of heart and lung disease that may relate to their healthy life style. We wished to determine whether multiple sclerosis (MS) was less frequent in this religious body. To ascertain this, diagnostic and treatment coding records were accessed from the Deseret Mutual Benefit Administrators (DMBA) for the 6 year period 1997-2002. DMBA is a medical insurance company that provides medical insurance to all employees of LDS Church in the US. This information was combined with prescribing records for disease modifying treatment, principally beta-interferon and Copaxone which are medications specific to MS. Using various search strategies we derived an approximate MS prevalence of 45-64/100,000. Comparison with MS rates from Utah and other states of comparable latitude suggest that strict LDS have an MS prevalence that is lower than expected and may reflect their healthy life style.

  5. DeMand: A tool for evaluating and comparing device-level demand and supply forecast models

    Neupane, Bijay; Siksnys, Laurynas; Pedersen, Torben Bach

    2016-01-01

    Fine-grained device-level predictions of both shiftable and non-shiftable energy demand and supply is vital in order to take advantage of Demand Response (DR) for efficient utilization of Renewable Energy Sources. The selection of an effective device-level load forecast model is a challenging task......, mainly due to the diversity of the models and the lack of proper tools and datasets that can be used to validate them. In this paper, we introduce the DeMand system for fine-tuning, analyzing, and validating the device-level forecast models. The system offers several built-in device-level measurement...... datasets, forecast models, features, and errors measures, thus semi-automating most of the steps of the forecast model selection and validation process. This paper presents the architecture and data model of the DeMand system; and provides a use-case example on how one particular forecast model...

  6. Hemoglobin affinity in Andean rodents

    HRVOJ OSTOJIC

    2002-01-01

    Full Text Available Blood hemoglobin oxygen affinity (P50 was measured in three Andean species and in the laboratory rat (control, all raised near sea level. Chinchilla lanigera (Molina, 1792 has an altitudinal habitat range from low Andean slopes up to 3000 m., while Chinchilla brevicaudata (Waterhouse, 1848 has an altitudinal range from 3000 to 5000 m. The laboratory type guinea pig, wild type guinea pig (Cavia porcellus, (Waterhouse, 1748, and laboratory rat (Rattus norvegicus were also raised at sea level. The Andean species had high hemoglobin oxygen affinities (low P50 compared with the rat. Chinchilla brevicaudata had a higher affinity than Chinchilla lanigera. The wild type guinea pig had a higher affinity than the laboratory type. As has been shown in other species, this is another example of an inverse correlation between the altitude level and the P50 values. This is the first hemoglobin oxygen affinity study in Chinchilla brevicaudata.

  7. Bathymetry of Lake Erie and Lake Saint Clair

    National Oceanic and Atmospheric Administration, Department of Commerce — Bathymetry of Lake Erie and Lake Saint Clair has been compiled as a component of a NOAA project to rescue Great Lakes lake floor geological and geophysical data and...

  8. Hemoglobin Wayne Trait with Incidental Polycythemia.

    Ambelil, Manju; Nguyen, Nghia; Dasgupta, Amitava; Risin, Semyon; Wahed, Amer

    2017-01-01

    Hemoglobinopathies, caused by mutations in the globin genes, are one of the most common inherited disorders. Many of the hemoglobin variants can be identified by hemoglobin analysis using conventional electrophoresis and high performance liquid chromatography; however hemoglobin DNA analysis may be necessary in other cases for confirmation. Here, we report a case of a rare alpha chain hemoglobin variant, hemoglobin Wayne, in a 47-year-old man who presented with secondary polycythemia. Capillary zone electrophoresis and high performance liquid chromatography revealed a significant amount of a hemoglobin variant, which was further confirmed by hemoglobin DNA sequencing as hemoglobin Wayne. Since the patient was not homozygous for hemoglobin Wayne, which is associated with secondary polycythemia, the laboratory diagnosis in this case was critical in ruling out hemoglobinopathy as the etiology of his polycythemia. © 2017 by the Association of Clinical Scientists, Inc.

  9. ALICE takes root in Saint-Genis-Pouilly

    Patrice Loiez

    2004-01-01

    To celebrate the CERN 50th anniversary and to emphasize the close ties between the community of Saint-Genis-Pouilly, CERN and the ALICE Collaboration, Hubert Bertrand, Mayor of Saint-Genis-Pouilly and Christian Fabjan, Technical Coordinator of the ALICE Experiment, planted a tree on Saturday 16 October 2004 in front of the Jean Monet Culture Center.

  10. ALICE takes root in Saint-Genis-Pouilly

    2004-01-01

    To celebrate the CERN 50th anniversary and to emphasize the close ties between the community of Saint-Genis-Pouilly, CERN and the ALICE Collaboration, Hubert Bertrand, Mayor of Saint-Genis-Pouilly and Christian Fabjan, Technical Coordinator of the ALICE Experiment, planted a tree on Saturday 16 October 2004 in front of the Jean Monet Culture Center.

  11. Screening of "Particule Fever" at Saint-Genis

    Brice, Maximilien

    2015-01-01

    La Mission Permanente de la France auprès des Nations Unies organise une projection gratuite du film "Particle Fever" jeudi 19 février 2015 à 19h30 au théâtre du Bordeau de Saint-Genis-Pouilly. Ce partenariat avec le CERN et la Ville de Saint-Genis-Pouilly permet de comprendre, au travers de ce film captivant, l'activité du CERN.

  12. Hemoglobin and heme scavenger receptors

    Nielsen, Marianne Jensby; Møller, Holger Jon; Moestrup, Søren Kragh

    2010-01-01

    Heme, the functional group of hemoglobin, myoglobin, and other hemoproteins, is a highly toxic substance when it appears in the extracellular milieu. To circumvent potential harmful effects of heme from hemoproteins released during physiological or pathological cell damage (such as hemolysis...... and rhabdomyolysis), specific high capacity scavenging systems have evolved in the mammalian organism. Two major systems, which essentially function in a similar way by means of a circulating latent plasma carrier protein that upon ligand binding is recognized by a receptor, are represented by a) the hemoglobin...

  13. Los juegos antropologicos de Saint-Louis

    Fabrice Delsahut

    2011-12-01

    Full Text Available En 1904, en medio de la feria de la exposición universal de Saint-Louis, los Juegos olimpicos no pudieron escapar a la ascención de ideologías racistas del principios del siglo XX y contibuyeron a la discusión del mérito atlético de diferentes razas. Los organisadores prepararon competiciones especiales que llamaron en esta ocasión «Jornadas antropológicas» reservadas a los que la América segregacionista del momento consideraba como primitivos. El impacto de los estudios sobre las razas, sobre la manera de pensar en el deporte no fue, al contrario de lo que se esforzaron hacer creer los diferentes presidentes del C.O.I en el curso de las siguientes decadas, un simple avatar del movimiento olimpico. Veremos la influencía de este espectáculo atletico interracial en los Estados Unidos pero tambien en el mundo, particularmente a través del papel de la prensa. Las jornadas antropológicas permitieron indudablemente elaborar una cierta percepción de la otricidad y limitaran la integración de los pueblos autóctonas en la maquina deportiva mundial.

  14. Earthquake Magnitude Relationships for the Saint Peter and Saint Paul Archipelago, Equatorial Atlantic

    de Melo, Guilherme W. S.; do Nascimento, Aderson F.

    2018-03-01

    We have investigated several relationships between ML, M(NEIC) and Mw for the earthquakes locally recorded in the Saint Peter and Saint Paul Archipelago (SPSPA), Equatorial Atlantic. Because we only have one station in the area, we could not derive attenuation relations for events recorded at different distances at different stations. Our approach was then to compare our ML estimates with magnitudes reported by NEIC. This approach produced acceptable results particularly for epicentral distance smaller than 100 km. For distances greater that 100 km, there is a systematic increase in the residuals probable due to the lack of station correction and our inability to accurately estimate Q. We also investigate the Mw—M(NEIC) relationship. We find that Mw estimates using S-wave produce smaller residuals when compared with both M(NEIC). Finally, we also investigate the ML—Mw relationship and observe that given the data set we have, the 1:1 holds. We believe that the use of the present methodologies provide consistent magnitude estimates between all the magnitudes investigated that could be used to better assess seismic hazard in the region.

  15. Particular intervention plan of the Saint Alban-Saint Maurice l'Exil Nuclear Power Plant

    2010-01-01

    The Particular intervention plan (PPI in French) is an emergency plan which foresees the measures and means to be implemented to address the potential risks of the presence and operation of a nuclear facility. This plan is implemented and developed by the Prefect in case of nuclear accident (or incident leading to a potential accident), the impact of which extending beyond the facility perimeter. It represents a special section of the organisation plan for civil protection response (ORSEC plan). The PPI foresees the necessary measures and means for crisis management during the first hours following the accident and is triggered by the Department Prefect according to the information provided by the facility operator. Its aim is to protect the populations leaving within 10 km of the facility against a potential radiological hazard. The PPI describes: the facility, the intervention area, the protection measures for the population, the conditions of emergency plan triggering, the crisis organisation, the action forms of the different services, and the post-accident stage. This document is the public version of the Particular intervention plan of the Saint Alban-Saint Maurice NPP (Isere, France)

  16. Nuclear safety and radiation protection report of the Saint-Alban-Saint-Maurice nuclear facilities - 2011

    2012-01-01

    This safety report was established under the article 21 of the French law no. 2006-686 of June 13, 2006 relative to nuclear safety and information transparency. It presents, first, the facilities of the Saint-Alban-Saint-Maurice nuclear power plant (INB 119 and 120, Isere (FR)). Then, the nuclear safety and radiation protection measures taken regarding the facilities are reviewed: nuclear safety definition, radiation protection of intervening parties, safety and radiation protection improvement paths, crisis management, external and internal controls, technical situation of facilities, administrative procedures in progress. The incidents and accidents which occurred in 2011, are reported as well as the radioactive and non-radioactive (chemical, thermal) effluents discharge in the environment. Finally, The radioactive materials and wastes generated by the facilities are presented and sorted by type of waste, quantities and type of conditioning. Other environmental impacts (noise) are presented with their mitigation measures. Actions in favour of transparency and public information are presented as well. The document concludes with a glossary and a list of recommendations from the Committees for health, safety and working conditions. (J.S.)

  17. Nuclear safety and radiation protection report of the Saint-Alban-Saint-Maurice nuclear facilities - 2010

    2011-06-01

    This safety report was established under the article 21 of the French law no. 2006-686 of June 13, 2006 relative to nuclear safety and information transparency. It presents, first, the facilities of the Saint-Alban-Saint-Maurice nuclear power plant (INB 119 and 120, Isere (FR)). Then, the nuclear safety and radiation protection measures taken regarding the facilities are reviewed: nuclear safety definition, radiation protection of intervening parties, safety and radiation protection improvement paths, crisis management, external and internal controls, technical situation of facilities, administrative procedures in progress. The incidents and accidents which occurred in 2010, are reported as well as the radioactive and non-radioactive (chemical, thermal) effluents discharge in the environment. Finally, The radioactive materials and wastes generated by the facilities are presented and sorted by type of waste, quantities and type of conditioning. Other environmental impacts (noise) are presented with their mitigation measures. Actions in favour of transparency and public information are presented as well. The document concludes with a glossary and a list of recommendations from the Committees for health, safety and working conditions. (J.S.)

  18. Blood Test: Hemoglobin A1C

    ... Why Are Hemoglobin A1c Tests Done? When a child has diabetes, hemoglobin A1c levels are followed to see how well medicines are working. If a child with diabetes has a high hemoglobin A1c level, it may ...

  19. Characteristic emission in glutaraldehyde polymerized hemoglobin

    Ma Li; Wang Xiaojun

    2011-01-01

    Hemoglobin with different modifications has been investigated using spectroscopic techniques. A new emission at around 371 nm has been observed under excitation of 305 nm from glutaraldehyde polymerized human hemoglobin. Intensity and peak position of the emission are dependent on both oxidation state and ligand environment and the emission has been identified from the hemoglobin oligomer.

  20. Patriarch Ephrem: A late medieval saintly cult

    Popović Danica

    2006-01-01

    Full Text Available Patriarch Ephrem, monk and hermit, writer and saint, Bulgarian-born but twice the leader of the Serbian Church (1375-78 and 1389-92, is an outstanding figure of the late medieval Balkans. His "life and works" are discussed here in the light of hagiological texts and the information provided by various types of sources with the view to drawing some historically relevant conclusions. The main source of information about Ephrem's life and activity are the eulogies, Life and service composed by bishop Mark, his disciple and loyal follower for twenty-three years. Making use of hagiographical topica combined with plentiful data of undoubted documentary value, he relates the story of Ephrem's life through all of its major stages: from his birth and youth to his withdrawal from the world and taking of a monk's habit. Of formative influence were his years on the Holy Mount Athos, where he experienced different styles of monastic life, coenobitic, as well as solitary, which he practiced in the well-known hermitages in the heights of Athos. The further course of Ephrem's life was decided by the turbulent developments in the Balkans brought about by the Ottoman conquests. In that sense, his biography, full of forced and voluntary resettlements, is a true expression of the spirit of the times. Forced to flee Mount Athos, Ephrem made a short stay in Bulgaria and then, about 1347, came to Serbia, where he spent the rest of his life. An eminent representative of the monastic elite and under the aegis of the Serbian patriarch, he spent ten years in a hesychastria of the Monastery of Decani. For reasons of security, he then moved to a cave hermitage founded specially for him in the vicinity of the Patriarchate of Pec. It was in that cell, where he lived for twenty years powerfully influencing the monastic environment, that his literary work profoundly marked by hesychast thought and eschatology, was created. Ephrem twice accepted the office of patriarch in the

  1. Sainte-Bernardette du Banlay, Nevers

    Christophe Joly

    2009-11-01

    Full Text Available Construite par Claude Parent et Paul Virilio en 1964-1965, l’église Sainte-Bernadette du Banlay témoigne de leurs travaux sur la fonction oblique. L’édifice fut édifié à l’issue d’un concours d’architecture lancé en 1963 par Mgr Vial et l’Abbé Bourgoin, curé de la paroisse. L’église est inspirée de l’architecture des bunkers. Deux coques de béton s’imbriquent l’une dans l’autre en se décalant par rapport à l’axe longitudinal. L’apparence générale est un édifice monolithique, qui évoque un rocher. Á l’intérieur, deux grands plans obliques paraissent exhumés pour constituer la nef et le chœur. En relation étroite avec la grotte des apparitions de Lourdes, l’église est construite comme une crypte suspendue dont la coupe adopte la forme d’un cœur. Par le choix de matériaux bruts et d’un éclairage zénithal, les architectes confèrent à l’ensemble une étonnante intimité. C’est par l’opposition entre le volume extérieur austère et fermé et l’espace intérieur accueillant et protecteur que les concepteurs expriment la nouvelle fonction d’une église conçue dans une période d’incertitude et de tensions.The Sainte-Bernadette du Banlay church at Nevers was built from 1964 to 1965 to the designs of the architects Claude Parent and Paul Virilio, working on their theme of the oblique function. It was the fruit of an architectural competition organised in 1963 by Monseigneur Vial and the Abbé Bourgoin, the parish priest. The church’s architecture is inspired by that of defensive bunkers. Two reinforced concrete shells are joined the one into the other but out of true on a longitudinal axis. The overall appearance of the church is that of a monolithic block, something like a rock. Inside, two large oblique planes seem to emerge to create the nave and the chancel. Closely related to the Lourdes grotto of the Virgin’s appearances, the church is designed as a suspended crypt

  2. The Rule of Saint Basil the Great

    Piotr Pietrow

    2014-11-01

    Full Text Available The rules of monasticism were collected and published in a single work entitled Asketikon by Saint Basil the Great. It is arranged in the form of questions and answers to create one coherent work. It has two different publications.The first publication named The Small Asketikon dates to 370-370. It is the fruit of the Saint’s work among Pontic communities and consists of 203 questions and answers. The orignial Greek manuscript has not survived and it is available only in two translations: the Latin Rufin and fragments in Syrian language. The second publication named The Great Asketikon appeard in about 377 and presents the most mature step of cenobitic monasticismin Basil’s elaboration. The Great Asketikon was created by adding new questions to The Small Asketikon and consists of two parts called the The Longer Rules and The Shorter Rules. The Longer Rules are primarily a set of questions and answers. It includes a wide range of rules and norms of the overall life in community. It refers to the fundamental rules of spirituality, such as love, sacrifice, obedience and rudimental problems connected withcommunity organization, cenobitic monasticism and the role of the superior, work and prayer. The second part of The Great Asketikon consists of shorter rules. Two publications are known: the first one originated in Pont andincludes 286 questions and answers and second arose in Cezarei and includes 318 questions and answers. In this work, the Hierarch explains in detail issues regarding community life and solves difficult problems connected with conscience. He writes about behavior towards brothers and explains the significance of weaknesses and virtues.

  3. Hemoglobin Test: MedlinePlus Lab Test Information

    ... page: https://medlineplus.gov/labtests/hemoglobintest.html Hemoglobin Test To use the sharing features on this page, please enable JavaScript. What is a Hemoglobin Test? A hemoglobin test measures the levels of hemoglobin ...

  4. Hemoglobin Function in Stored Blood.

    1974-08-01

    States during 1973. Several advantages over ACA) are important. Blood stored in CPD maintains higher ./ levels of 2,3-DPG (2,3- diphosphoglycerate ) and a...survival and ATP levels in stored blood is explained by the several functions of ATP which are necessary for cell viability. However, ATP levels do...not correlate with oxygen affinity during storage. Levels of 2,3-DPG determine oxygen affinity and thus hemoglobin function. (12,13) When normal levels

  5. Tumor odontogênico adenomatóide em mandíbula Tumor odontógeno adenomatoide de la mandíbula Adenomatoid odontogenic tumor in mandible

    Roberto de Almeida Azevedo

    2011-06-01

    Full Text Available Tumor odontogênico adenomatóide é uma lesão relativamente incomum, que acomete preferencialmente indivíduos do sexo feminino durante a segunda década de vida. Exibe como sítio de predileção a região anterior da maxila, é geralmente associado à coroa de um dente incluso. Este trabalho tem o objetivo de apresentar um caso clínico de tumor odontogênico adenomatóide. Este se apresenta localizado em região anterior da mandíbula. Pretende-se ainda abordar suas características clínicas, radiográficas e histológicas, além do tratamento cirúrgico conservador de eleição.El tumor odontógeno adenomatoide es una lesión relativamente infrecuente que afecta principalmente a las mujeres durante la segunda década de vida, porque su sitio predilecto es la región anterior de la mandíbula, con una lesión por lo general asociada con la corona del diente. Se reporta un caso de tumor odontógeno adenomatoide en la región anterior de la mandíbula junto con sus resultados clínicos, radiológicos e histológicos así como su tratamiento quirúrgico.Adenomatoid odontogenic tumor is a relatively uncommon lesion, which affects mainly individuals of the female during the second decade due, showing as a site of predilection for the anterior region of the maxilla presenting lesion usually associated with the crown of a tooth incluso. Os authors report a case of an adenomatoid odontogenic tumor in the anterior region of mandible, together with their clinical, radiographic and histological and its surgical treatment.

  6. Prevalence of ciguatoxins in lionfish (Pterois spp.) from Guadeloupe, Saint Martin, and Saint Barthélmy Islands (Caribbean).

    Soliño, Lucía; Widgy, Saha; Pautonnier, Anthony; Turquet, Jean; Loeffler, Christopher R; Flores Quintana, Harold A; Diogène, Jorge

    2015-08-01

    Lionfish (Pterois spp.) are invasive species that have recently spread throughout the Caribbean. Lionfish are available for purchase in local markets for human consumption in several islands of the region. We examined the prevalence of ciguatoxins (CTXs) in lionfish from the French Antilles, a ciguatera-endemic region. The neuroblastoma-2a (N2a) cell assay was used to assess composite cytotoxicity in 120 fish samples collected from the surrounding waters of Guadeloupe (n = 60), Saint Barthélemy Islands (n = 55) and Saint Martin (n = 5). Twenty-seven of these samples exhibited CTX-like activity by the N2a assay. Ciguatoxin (CTX) was confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in multiple samples that presented highest composite toxicity levels by N2a. Those fish found to contain CTXs were all from Saint Barthélemy. Lionfish from Guadeloupe and Saint Martin did not exhibit toxin activity, although the sample size from Saint Martin was insufficient to draw any conclusions as to the incidence of CTXs. In this study, we provide information about the potential hazard of ciguatera associated with the consumption of lionfish from known endemic areas. We also demonstrate the utility of the cell-based assay combined with LC-MS/MS to assess activity and to provide structural confirmation of CTXs respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Energy Transition Initiative: Island Energy Snapshot - Saint Martin/Sint Maarten

    2015-09-01

    This profile provides a snapshot of the energy landscape of the northeast Caribbean island Saint Martin. The island is divided between two nations, France in the north (Saint-Martin) and the Netherlands in the south (Sint Maarten).

  8. Des saints pour la fiction, des saints face à l’Histoire

    Aude Bonord

    2008-12-01

    Full Text Available Pourquoi des écrivains non confessionnels (Joseph Delteil, Blaise Cendrars, Christian Bobin, Sylvie Germain, Claude Louis-Combet ont-ils choisi de réécrire des vies de saints au XXe siècle ? Le parti pris est surprenant à plusieurs titres. L’hagiographie est un genre historique et religieux, terrain a priori réservé aux historiens, aux ecclésiastiques ou aux écrivains catholiques. De plus, à la fin du siècle, l’hagiographie est sortie du champ littéraire avec la disparition du groupe des écrivains catholiques. Curieusement, nos auteurs vont s’inscrire dans ces décalages non seulement pour définir leur place par rapport à l’hagiographe traditionnel mais aussi pour s’approprier le genre. Amorces fictionnelles et objets de rêveries poétiques, les vies de saints sont soumises à la fantaisie littéraire de ces auteurs au statut improbable. Dans un dialogue avec les sources allant du jeu à la contestation, les écrivains utilisent l’intertexte hagiographique, et notamment son système narratif, pour s’évader dans le merveilleux mais encore pour penser leur époque. En effet, si éloignée de la réalité contemporaine soit-elle en apparence, l’hagiographie joue à la fois un rôle de contrepoint et de reflet du présent. La confrontation avec ces récits surgis du passé permet alors aux auteurs de repenser la marche de l’Histoire et l’inscription de l’Homme dans le temps.

  9. Microseismic noise in the Saint Peter and Saint Paul Archipelago, equatorial Atlantic

    de Queiroz, Daniel É.; do Nascimento, Aderson F.; Schimmel, Martin

    2017-12-01

    Microseismic noise, also known as ambient seismic noise, are continuous vibrations mostly composed of Rayleigh waves pervasively recorded in the mili Hertz to 1 Hz frequency range. Their precise source mechanisms are under investigations and related to atmospheric perturbations and ocean gravity waves. Our purpose is to show the behavior of the microseismic noise recorded in the Saint Peter and Saint Paul Archipelago (SPSPA) with respect to wind intensity and ocean waves height in this region, between the North and South Atlantic Ocean. We have recorded both primary microseisms (PM) 0.04-0.12 Hz and the secondary microseisms (SM) 0.12-0.4 Hz during almost four years (2012-2015) and we used frequency, temporal, spatial and statistical correlation analysis to do qualitative and quantitative analysis with respect to wind speed intensity and significant wave height for the same periods. The results indicate a good correlation between the PM and the SM noise in the region particularly during the winter in the Northern Hemisphere and a poor correlation during the summer. We have also shown that probably most of the PM are generated in the SPSPA itself. We note that the intensity of SM recorded in SPSPA appears to have a seasonal behavior with the summer and winter in the Northern Hemisphere, and seems to influence the correlation between the PM and the SM, suggesting that the sources of the PM and the SM are not related to the same atmospheric event and from different places. PM generation would occur near the SPSPA whilst the SM would have distant sources towards the North Atlantic.

  10. Ácido mandélico: Modelado de su estructura y espectro de rotación

    Lirio Martínez, Ángel

    2016-01-01

    En este trabajo, se ha realizado el modelado teórico del panorama conformacional de la molécula del ácido mandélico, mediante el uso de diversos tipos de métodos computacionales. Una vez obtenidos los confórmeros más estables, todos con energías menores a 1000 cm-1, se llevado a cabo un análisis de las interacciones intramoleculares que se dan. A partir de los datos obtenidos se ha realizado el modelado del espectro de rotación de cada confórmero, en el rango del espectro de 1...

  11. Uso de la morfometría de las mandíbulas de cefalópodos en estudios de contenido estomacal

    Vega,Marco Antonio

    2011-01-01

    La sistemática y taxonomía de cefalópodos del mar de Chile, sigue siendo escasa e incompleta. Muchas especies, raramente son capturadas por métodos convencionales, y regularmente son colectadas de estómagos de depredadores. La identificación en los estómagos se realiza, con frecuencia, mediante sus mandíbulas o picos córneos. En nuestra costa estas estructuras, en general, son poco utilizadas con fines taxonómicos. Este estudio describe y analiza preliminarmente la morfometría de 111 mandíbul...

  12. The church Saint-Symphorien in Nuits-Saint-Georges. An architectural and decorative syncretism, ca 1220-1240

    Sylvain Demarthe

    2011-12-01

    Full Text Available Saint Symphorian’s church in Nuits-Saint-Georges (Burgundy, which dates from near 1220-1240, is situated during the transition of two architectural styles and attests a local but rather backward-looking Cistercian legacy that some Gothic urban and more innovative elements modernize. Moreover the church takes part, for the same reasons as those in Agencourt, Gerland and Prissey, in the surprising wave of reconstructions which denotes among others the important economic development of the country of Cîteaux at the beginning of the 13th century.

  13. PLASMA PROTEIN AND HEMOGLOBIN PRODUCTION

    Robscheit-Robbins, F. S.; Miller, L. L.; Whipple, G. H.

    1947-01-01

    Given healthy dogs fed abundant iron and protein-free or low protein diets with sustained anemia and hypoproteinemia, we can study the capacity of these animals to produce simultaneously new hemoglobin and plasma protein. Reserve stores of blood protein-building materials are measurably depleted and levels of 6 to 8 gm. per cent for hemoglobin and 4 to 5 gm. per cent for plasma protein can be maintained for weeks or months depending upon the intake of food proteins or amino acid mixtures. These dogs are very susceptible to infection and various poisons. Dogs tire of these diets and loss of appetite terminates many experiments. Under these conditions (double depletion) standard growth mixtures of essential amino acids are tested to show the response in blood protein output and urinary nitrogen balance. As a part of each tabulated experiment one of the essential amino acids is deleted from the complete growth mixture to compare such response with that of the whole mixture. Methionine, threonine, phenylalanine, and tryptophane when singly eliminated from the complete amino acid mixture do effect a sharp rise in urinary nitrogen. This loss of urinary nitrogen is corrected when the individual amino acid is replaced in the mixture. Histidine, lysine, and valine have a moderate influence upon urinary nitrogen balance toward nitrogen conservation. Leucine, isoleucine, and arginine have minimal or no effect upon urinary nitrogen balance when these individual amino acids are deleted from the complete growth mixture of amino acids during 3 to 4 week periods. Tryptophane and to a less extent phenylalanine and threonine when returned to the amino acid mixture are associated with a conspicuous preponderance of plasma protein output over the hemoglobin output (Table 4). Arginine, lysine, and histidine when returned to the amino acid mixture are associated with a large preponderance of hemoglobin output. Various amino acid mixtures under these conditions may give a positive

  14. Hemoglobin Labeled by Radioactive Lysine

    Bale, W. F.; Yuile, C. L.; DeLaVergne, L.; Miller, L. L.; Whipple, G. H.

    1949-12-08

    This paper reports on the utilization of tagged epsilon carbon of DL-lysine by a dog both anemic and hypoproteinemic due to repeated bleeding plus a diet low in protein. The experiment extended over period of 234 days, a time sufficient to indicate an erythrocyte life span of at least 115 days based upon the rate of replacement of labeled red cell proteins. The proteins of broken down red cells seem not to be used with any great preference for the synthesis of new hemoglobin.

  15. Determination Of Ph Including Hemoglobin Correction

    Maynard, John D.; Hendee, Shonn P.; Rohrscheib, Mark R.; Nunez, David; Alam, M. Kathleen; Franke, James E.; Kemeny, Gabor J.

    2005-09-13

    Methods and apparatuses of determining the pH of a sample. A method can comprise determining an infrared spectrum of the sample, and determining the hemoglobin concentration of the sample. The hemoglobin concentration and the infrared spectrum can then be used to determine the pH of the sample. In some embodiments, the hemoglobin concentration can be used to select an model relating infrared spectra to pH that is applicable at the determined hemoglobin concentration. In other embodiments, a model relating hemoglobin concentration and infrared spectra to pH can be used. An apparatus according to the present invention can comprise an illumination system, adapted to supply radiation to a sample; a collection system, adapted to collect radiation expressed from the sample responsive to the incident radiation; and an analysis system, adapted to relate information about the incident radiation, the expressed radiation, and the hemoglobin concentration of the sample to pH.

  16. Hemoglobin Variants: Biochemical Properties and Clinical Correlates

    Thom, Christopher S.; Dickson, Claire F.; Gell, David A.; Weiss, Mitchell J.

    2013-01-01

    Diseases affecting hemoglobin synthesis and function are extremely common worldwide. More than 1000 naturally occurring human hemoglobin variants with single amino acid substitutions throughout the molecule have been discovered, mainly through their clinical and/or laboratory manifestations. These variants alter hemoglobin structure and biochemical properties with physiological effects ranging from insignificant to severe. Studies of these mutations in patients and in the laboratory have produced a wealth of information on hemoglobin biochemistry and biology with significant implications for hematology practice. More generally, landmark studies of hemoglobin performed over the past 60 years have established important paradigms for the disciplines of structural biology, genetics, biochemistry, and medicine. Here we review the major classes of hemoglobin variants, emphasizing general concepts and illustrative examples. PMID:23388674

  17. What Are Robespierre and Telemachus Doing in Saint-Domingue?

    Kjærgård, Jonas Ross

    2018-01-01

    Charles Pigault-Lebrun's play Le blanc et le noir (1795) is one of only a handful of French revolutionary plays to stage the Saint-Domingue slave rebellion, a rebellion today better known as the Haitian Revolution (1791–1804). I argue that Pigault-Lebrun uses early melodramatic generic traits to ...

  18. Life and death at precolumbian Lavoutte, Saint Lucia, Lesser Antilles

    Hofman, C.L.; Hoogland, M.L.P.; Mickleburgh, H.L.; Laffoon, J.E.; Weston, D.A.; Field, M.H.

    2012-01-01

    The Caribbean archaeological record requires immediate attention and protection. Development and natural forces have impacted archaeological sites, destroying or severely damaging them. The precolumbian site of Lavoutte, located in northern Saint Lucia, has been known as a major Late Ceramic Age

  19. Calculation of Void in the Fort Saint Vrain Material

    Potter, David Charles [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Taylor, Craig Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Coons, James Elmer [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-11

    The percent void of the Fort Saint Vrain (FSV) material is estimated to be 21.1% based on the volume of the gap at the top of the drums, the volume of the coolant channels in the FSV fuel element, and the volume of the fuel handling channel in the FSV fuel element.

  20. Manipulation of Motivating Operations and Use of a Script-Fading Procedure to Teach Mands for Location to Children with Language Delays

    Howlett, Melissa A.; Sidener, Tina M.; Progar, Patrick R.; Sidener, David W.

    2011-01-01

    The effects of contriving motivating operations (MOs) and script fading on the acquisition of the mand "Where's [object]?" were evaluated in 2 boys with language delays. During each session, trials were alternated in which high-preference items were present (abolishing operation [AO] trials) or missing (establishing operation [EO] trials) from…

  1. Determination of Human Hemoglobin Derivatives.

    Attia, Atef M M; Ibrahim, Fatma A A; Abd El-Latif, Noha A; Aziz, Samir W; Abdelmottaleb Moussa, Sherif A; Elalfy, Mohsen S

    2015-01-01

    The levels of the inactive hemoglobin (Hb) pigments [such as methemoglobin (metHb), carboxyhemoglobin (HbCO) and sulfohemoglobin (SHb)] and the active Hb [in the oxyhemoglobin (oxyHb) form] as well as the blood Hb concentration in healthy non pregnant female volunteers were determined using a newly developed multi-component spectrophotometric method. The results of this method revealed values of SHb% in the range (0.0727-0.370%), metHb% (0.43-1.0%), HbCO% (0.4-1.52%) and oxyHb% (97.06-98.62%). Furthermore, the results of this method revealed values of blood Hb concentration in the range (12.608-15.777 g/dL). The method is highly sensitive, accurate and reproducible.

  2. Biological variability of glycated hemoglobin.

    Braga, Federica; Dolci, Alberto; Mosca, Andrea; Panteghini, Mauro

    2010-11-11

    The measurement of glycated hemoglobin (HbA(1c)) has a pivotal role in monitoring glycemic state in diabetic patients. Furthermore, the American Diabetes Association has recently recommended the use of HbA(1c) for diabetes diagnosis, but a clear definition of the clinically allowable measurement error is still lacking. Information on biological variability of the analyte can be used to achieve this goal. We systematically reviewed the published studies on the biological variation of HbA(1c) to check consistency of available data in order to accurately define analytical goals. The nine recruited studies were limited by choice of analytic methodology, population selection, protocol application and statistical analyses. There is an urgent need to determine biological variability of HbA(1c) using a specific and traceable assay, appropriate protocol and appropriate statistical evaluation of data. 2010 Elsevier B.V. All rights reserved.

  3. THE BIOCHEMISTRY OF VITREOSCILLA HEMOGLOBIN

    Benjamin C. Stark

    2012-10-01

    Full Text Available The hemoglobin (VHb from Vitreoscilla was the first bacterial hemoglobin discovered. Its structure and function have been extensively investigated, and engineering of a wide variety of heterologous organisms to express VHb has been performed to increase their growth and productivity. This strategy has shown promise in applications as far-ranging as the production of antibiotics and petrochemical replacements by microorganisms to increasing stress tolerance in plants. These applications of “VHb technology” have generally been of the “black box” variety, wherein the endpoint studied is an increase in the levels of a certain product or improved growth and survival. Their eventual optimization, however, will require a thorough understanding of the various functions and activities of VHb, and how VHb expression ripples to affect metabolism more generally. Here we review the current knowledge of these topics. VHb's functions all involve oxygen binding (and often delivery in one way or another. Several biochemical and structure-function studies have provided an insight into the molecular details of this binding and delivery. VHb activities are varied. They include supply of oxygen to oxygenases and the respiratory chain, particularly under low oxygen conditions; oxygen sensing and modulation of transcription factor activity; and detoxification of NO, and seem to require interactions of VHb with “partner proteins”. VHb expression affects the levels of ATP and NADH, although not enormously. VHb expression may affect the level of many compounds of intermediary metabolism, and, apparently, alters the levels of expression of many genes. Thus, the metabolic changes in organisms engineered to express VHb are likely to be numerous and complicated.

  4. Led Astray by Hemoglobin A1c

    Jean Chen MD

    2016-01-01

    Full Text Available Hemoglobin A1c (A1c is used frequently to diagnose and treat diabetes mellitus. Therefore, it is important be aware of factors that may interfere with the accuracy of A1c measurements. This is a case of a rare hemoglobin variant that falsely elevated a nondiabetic patient’s A1c level and led to a misdiagnosis of diabetes. A 67-year-old male presented to endocrine clinic for further management after he was diagnosed with diabetes based on an elevated A1c of 10.7%, which is approximately equivalent to an average blood glucose of 260 mg/dL. Multiple repeat A1c levels remained >10%, but his home fasting and random glucose monitoring ranged from 92 to 130 mg/dL. Hemoglobin electrophoresis and subsequent genetic analysis diagnosed the patient with hemoglobin Wayne, a rare hemoglobin variant. This variant falsely elevates A1c levels when A1c is measured using cation-exchange high-performance liquid chromatography. When the boronate affinity method was applied instead, the patient’s A1c level was actually 4.7%. Though hemoglobin Wayne is clinically silent, this patient was erroneously diagnosed with diabetes and started on an antiglycemic medication. Due to this misdiagnosis, the patient was at risk of escalation in his “diabetes management” and hypoglycemia. Therefore, it is important that providers are aware of factors that may result in hemoglobin A1c inaccuracy including hemoglobin variants.

  5. Hemoglobin Values During Pregnancy | Leffler | Nigerian Medical ...

    It is known that the iron turnover in expectant mothers is up to three times that of an average adult. This is reflected in lower hemoglobin levels. The study showed that hemoglobin levels can be maintained by taking Bio-Strath®, provided that the patients' diet contains adequate fresh fruits and vegetables, whole grains, lean ...

  6. Spectroscopic study of gamma irradiated bovine hemoglobin

    Maghraby, Ahmed Mohamed; Ali, Maha Anwar

    2007-01-01

    In the present study, the effects of ionizing radiation of Cs-137 and Co-60 from 4.95 to 743.14 Gy and from 40 Gy to 300 kGy, respectively, on some bovine hemoglobin characteristics were studied. Such an effect was evaluated using electron paramagnetic resonance (EPR) spectroscopy, and infra-red (IR) spectroscopy. Bovine hemoglobin EPR spectra were recorded and analyzed before and after irradiation and changes were explained in detail. IR spectra of unirradiated and irradiated Bovine hemoglobin were recorded and analyzed also. It was found that ionizing radiation may lead to the increase of free radicals production, the decrease in α-helices contents, which reflects the degradation of hemoglobin molecular structure, or at least its incomplete performance. Results also show that the combined application of EPR and FTIR spectroscopy is a powerful tool for determining structural modification of bovine hemoglobin samples exposed to gamma irradiation

  7. Spin Label Studies of the Hemoglobin-Membrane Interaction During Sickle Hemoglobin Polymerization

    Falcon Dieguez, Jose E.; Rodi, Pablo; Lores Guevara, Manuel A.; Gennaro, Ana Maria

    2009-12-01

    An enhanced hemoglobin-membrane association has been previously documented in Sickle Cell Anemia. However, it is not known how this interaction is modified during the hemoglobin S polymerization process. In this work, we use a model of reconstituted erythrocytes from ghost membranes whose cytoskeleton proteins had been previously labeled with the 4-maleimido Tempo spin label, and that were subsequently resealed with hemoglobin S or A solutions. Using EPR spectroscopy, we studied the time dependence of the spectral W/S parameter, indicative of the conformational state of cytoskeleton proteins (mainly spectrin) under spontaneous deoxygenation, with the aim of detecting the eventual effects due to hemoglobin S polymerization. The differences observed in the temporal behaviour of W/S in erythrocytes reconstituted with both hemoglobins were considered as experimental evidence of an increment in hemoglobin S-membrane interaction, as a result of the polymerization process of hemoglobin S under spontaneous deoxygenation. (author)

  8. Radioimmunochemical characterization of hemoglobins Lepore and Kenya: unique antigenic determinants located on hybrid hemoglobins

    Garver, F.A.; Altay, G.; Baker, M.M.; Gravely, M.; Huisman, T.H.J.

    1978-01-01

    Antisera were produced in rabbits to the three known types of Lepore hemoglobins, which contain hybrid delta-β non-α-chains, and to hemoglobin Kenya, which has a hybrid γ-β non-α-chain. By using a sensitive radioimmunoassay technique, the absorbed antisera were shown to contain an antibody population that was specific for the hybrid hemoglobin and did not cross-react with normal hemoglobins. However, with the absorbed Lepore-specific antisera, the three known types of Lepore hemoglobins were antigenically indistinguishable from each other, suggesting that antibodies are not produced to the primary structural differences which define the three non-α-chains of the Lepore hemoglobins. These studies demonstrate that the non-α-subunits of hemoglobins Lepore and Kenya possess unique antigenic determinant sites, evidently resulting from an altered polypeptide conformation

  9. UNDER THE PROTECTION OF THE GOD'S SAINT. DYKANKA IMAGE OF SAINT NICHOLAS THE WONDER-WORKER AND ITS ROLE IN NIKOLAI GOGOL'S LIFE

    Voropaev V. A.

    2008-11-01

    Full Text Available The article tells the history of St. Nicholas Church in Dykanka and its holy image of Saint Nicholas, examines some details of the Gogol family life, the legend of Maria Gogol-Yanovskaya's marriage and her oath in front of the Holy Saint icon.

  10. Christian Feasts dedicated to Saints – an Interdisciplinary Perspective

    Carmen-Maria Bolocan

    2012-06-01

    Full Text Available Our paper is an interdisciplinary approach, of linguistic and theological analysis of a few lexemes that define saints who became popular in the Romanian culture and spirituality. Our ancient church, a fundamental part of our culture, has always been a coagulant factor for the unity of the Romanians worldwide. And this is also proven by the use of the religious vocabulary in all the anthropological, territorial, socio-professional and socio-cultural variants of the national Romanian language.

  11. Saint-Augustin, Proudhon, antithèses

    Pasteur , Sébastien

    2005-01-01

    Proudhon cite peu Saint-Augustin, mais le parallèle d'un contexte historique à son tournant offre matière à réfléchir. D'autant que Proudhon, anticlérical concède au Père de l'Eglise, un rang de philosophe, occasion d'aborder la fondation du discours philosophique au travers de la confession.

  12. Business plan of a food truck in Saint Petersburg

    Zavyalova, Ekaterina

    2017-01-01

    The purpose of the thesis was to investigate how to write a proper business plan and then implement gained knowledge in creating a business plan of a food truck in Saint Petersburg. A business plan serves as a guide for an entrepreneur in the process of company establishment and enables to gain funding from potential investors. The primary objective was to study essential components of a business plan. The theoretical framework comprises of core issues on company establishment and desc...

  13. Sanctified madness: the God-intoxicated saints of Bengal.

    Morinis, A

    1985-01-01

    The saintly madman is a familiar character in South Asia. To outer appearances he is no different from a lunatic, but the mad saint comes to be revered because his idiocy is popularly believed to arise from a different cause than ordinary madness. The common psychopath neglects social conventions because his consciousness is dimmed by incapacity; the saintly madman also breaches convention, but does so because his heightened consciousness has liberated him from the bonds of convention that entrap ordinary people. In the terms of Hinduism, he has tasted the divine nectar of God-realization and has returned to the human realm intoxicated by the experience. In this paper two popular God intoxicated saints of Bengal are discussed. The question is posed whether 'God intoxication' can be considered a culture-bound syndrome of Bengal. The concept of 'culture bound syndrome' is found to be too narrow to encompass the most significant issues to arise from reflection on the characteristics of the God intoxicated. These larger issues have to do with the relationship between cultural practices and models and mental states (whether deviant, as implied by the term 'syndrome' although deviance does not always carry the negative connotation implicit in 'syndrome', or normal). It is suggested that all cultures culture a limited range of mental states and thus the questions posed by the notion of culture bound syndromes are subsumed by larger questions about the relationship of all mind-states to the socio-cultural environment which conditions them. The conclusion is that God intoxication is indeed a uniquely Bengali mental condition, with variants throughout South Asia and kinship to other mystical states, but that the concept of 'syndrome' is not useful.

  14. Please exercise extreme caution at the Saint-Genis roundabout

    2015-01-01

    In the interests of enhanced safety, a new pathway for pedestrians and cyclists has been constructed around the outside of the Saint-Genis roundabout. However, the markings of the previous cycle path, which is now closed to traffic, are still visible and can cause confusion. We therefore call on everyone to exercise extreme caution and to use the new pathway.   New two-way markings have been laid out, inviting pedestrians and cyclists coming from the direction of Saint-Genis-Pouilly to go towards the Swiss border or CERN Entrance E using the left-hand side of the roundabout (i.e. the Prévessin side). So, from now on, cyclists must no longer go around the roundabout on the right-hand side and pedestrians will no longer have to cross the D884 dual carriageway. Similarly, people staying at the Saint-Genis hostel are invited to follow these new markings to get to CERN or to return to the hostel, which means they will avoid having to cross the D35 highway at a spot where traffic is...

  15. Saint Petersburg magnetic observatory: from Voeikovo subdivision to INTERMAGNET certification

    Sidorov, Roman; Soloviev, Anatoly; Krasnoperov, Roman; Kudin, Dmitry; Grudnev, Andrei; Kopytenko, Yury; Kotikov, Andrei; Sergushin, Pavel

    2017-11-01

    Since June 2012 the Saint Petersburg magnetic observatory is being developed and maintained by two institutions of the Russian Academy of Sciences (RAS) - the Geophysical Center of RAS (GC RAS) and the Saint Petersburg branch of the Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation of RAS (IZMIRAN SPb). On 29 April 2016 the application of the Saint Petersburg observatory (IAGA code SPG) for introduction into the INTERMAGNET network was accepted after approval by the experts of the first definitive dataset over 2015, produced by the GC RAS, and on 9 June 2016 the SPG observatory was officially certified. One of the oldest series of magnetic observations, originating in 1834, was resumed in the 21st century, meeting the highest quality standards and all modern technical requirements. In this paper a brief historical and scientific background of the SPG observatory foundation and development is given, the stages of its renovation and upgrade in the 21st century are described, and information on its current state is provided. The first results of the observatory functioning are discussed and geomagnetic variations registered at the SPG observatory are assessed and compared with geomagnetic data from the INTERMAGNET observatories located in the same region.

  16. Saint Petersburg magnetic observatory: from Voeikovo subdivision to INTERMAGNET certification

    R. Sidorov

    2017-11-01

    Full Text Available Since June 2012 the Saint Petersburg magnetic observatory is being developed and maintained by two institutions of the Russian Academy of Sciences (RAS – the Geophysical Center of RAS (GC RAS and the Saint Petersburg branch of the Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation of RAS (IZMIRAN SPb. On 29 April 2016 the application of the Saint Petersburg observatory (IAGA code SPG for introduction into the INTERMAGNET network was accepted after approval by the experts of the first definitive dataset over 2015, produced by the GC RAS, and on 9 June 2016 the SPG observatory was officially certified. One of the oldest series of magnetic observations, originating in 1834, was resumed in the 21st century, meeting the highest quality standards and all modern technical requirements. In this paper a brief historical and scientific background of the SPG observatory foundation and development is given, the stages of its renovation and upgrade in the 21st century are described, and information on its current state is provided. The first results of the observatory functioning are discussed and geomagnetic variations registered at the SPG observatory are assessed and compared with geomagnetic data from the INTERMAGNET observatories located in the same region.

  17. Concomitant use of the matrix strategy and the mand-model procedure in teaching graphic symbol combinations.

    Nigam, Ravi; Schlosser, Ralf W; Lloyd, Lyle L

    2006-09-01

    Matrix strategies employing parts of speech arranged in systematic language matrices and milieu language teaching strategies have been successfully used to teach word combining skills to children who have cognitive disabilities and some functional speech. The present study investigated the acquisition and generalized production of two-term semantic relationships in a new population using new types of symbols. Three children with cognitive disabilities and little or no functional speech were taught to combine graphic symbols. The matrix strategy and the mand-model procedure were used concomitantly as intervention procedures. A multiple probe design across sets of action-object combinations with generalization probes of untrained combinations was used to teach the production of graphic symbol combinations. Results indicated that two of the three children learned the early syntactic-semantic rule of combining action-object symbols and demonstrated generalization to untrained action-object combinations and generalization across trainers. The results and future directions for research are discussed.

  18. Oxygen Measurements in Liposome Encapsulated Hemoglobin

    Phiri, Joshua Benjamin

    Liposome encapsulated hemoglobins (LEH's) are of current interest as blood substitutes. An analytical methodology for rapid non-invasive measurements of oxygen in artificial oxygen carriers is examined. High resolution optical absorption spectra are calculated by means of a one dimensional diffusion approximation. The encapsulated hemoglobin is prepared from fresh defibrinated bovine blood. Liposomes are prepared from hydrogenated soy phosphatidylcholine (HSPC), cholesterol and dicetylphosphate using a bath sonication method. An integrating sphere spectrophotometer is employed for diffuse optics measurements. Data is collected using an automated data acquisition system employing lock-in -amplifiers. The concentrations of hemoglobin derivatives are evaluated from the corresponding extinction coefficients using a numerical technique of singular value decomposition, and verification of the results is done using Monte Carlo simulations. In situ measurements are required for the determination of hemoglobin derivatives because most encapsulation methods invariably lead to the formation of methemoglobin, a nonfunctional form of hemoglobin. The methods employed in this work lead to high resolution absorption spectra of oxyhemoglobin and other derivatives in red blood cells and liposome encapsulated hemoglobin (LEH). The analysis using singular value decomposition method offers a quantitative means of calculating the fractions of oxyhemoglobin and other hemoglobin derivatives in LEH samples. The analytical methods developed in this work will become even more useful when production of LEH as a blood substitute is scaled up to large volumes.

  19. On the different meanings of the term law (zakon in Saint Sabba's Life of Saint Simon

    Šarkić Srđan N.

    2015-01-01

    Full Text Available In mediaeval Serbian law the central legal term zakon (law indicated a generally obligatory rule (regula iuris which was usually not a result of the activity of a monarch as ultimate holder of state power. Even where a law was made by state authority such a legal rule had primarily the appearence of a customary legal provision, regulating the conditions within one particular manor (vlastelinstvo rather than within the whole national territory. Otherwise such laws prescibed the legal position of different categories of inhabitants and identified particular rules of status. Sometimes a law would be introduced to regulate one paricular problem. The concept of law in this period also includes a legal rule derived from custom or from a private contract. Each of these uses can be illustrated from many hundreds of cases from several sources. The use of the term zakon (law was present in the literary sources as well, such is The Life of Saint Simon (biography of Stefan Nemanja, founder of Serbian mediaeval dynasty Nemanjić, written by his youngest son Rastko, bether known under his monastic name Sabba (Sava. In Sabba's hagiography of his father we found the term zakon six times. Discribing the State Council (Državni sabor that had to decide who will be Nemanja's successor on the throne, Sabba writes that his father pronounced, among other, the following words: 'My sons, do not forget the orthodox law that I established.' The term orthodox law means here orthodox faith, that was established in Serbia after persecutions of Bogomilian heresy. For the second time, term zakon was used in the meaning of monarch's order. Nemanja says to his sons not to forget his laws. Further, giving the instructions to his sons, Nemanja use the citation from the Bible (The Book of Proverbs or Proverbs of Solomon 3, 1-18, where the term zakon corresponds to the latin ius, not lex. Hereinafter the word zakon means Torah or Pentateuch, the first five books of Bible (citation

  20. Rahmaninov ja Saint-Saens Estonia kontserdisaalis / Tiina Õun

    Õun, Tiina, 1954-

    2005-01-01

    18. novembril Estonia kontserdisaalis toimuvast Sergei Rahmaninovi Klaverikontsert nr 2 ja "Kellad" ettekandest ja 29. novembril Toimuvast Camille Saint-Saensi ooperi "Simson ja Delila" kontsertettekandest

  1. Detection of Sickle Cell Hemoglobin in Haiti by Genotyping and Hemoglobin Solubility Tests

    Carter, Tamar E.; von Fricken, Michael; Romain, Jean R.; Memnon, Gladys; St. Victor, Yves; Schick, Laura; Okech, Bernard A.; Mulligan, Connie J.

    2014-01-01

    Sickle cell disease is a growing global health concern because infants born with the disorder in developing countries are now surviving longer with little access to diagnostic and management options. In Haiti, the current state of sickle cell disease/trait in the population is unclear. To inform future screening efforts in Haiti, we assayed sickle hemoglobin mutations using traditional hemoglobin solubility tests (HST) and add-on techniques, which incorporated spectrophotometry and insoluble hemoglobin separation. We also generated genotype data as a metric for HST performance. We found 19 of 202 individuals screened with HST were positive for sickle hemoglobin, five of whom did not carry the HbS allele. We show that spectrophotometry and insoluble hemoglobin separation add-on techniques could resolve false positives associated with the traditional HST approach, with some limitations. We also discuss the incorporation of insoluble hemoglobin separation observation with HST in suboptimal screening settings like Haiti. PMID:24957539

  2. Moessbauer study of hemoglobin of diabetes

    Li Aiguo; Ni Xinbo; Cai Yingwen; Zhang Guilin; Zhang Hongde; Ge Yongxin

    2000-01-01

    The hemoglobins from normal adults (Gly-Hb 5%), people infected with diabetes (Gly-Hb 10%) and serious diabetics (Gly-Hb 15%) were investigated by Moessbauer spectroscopy at liquid nitrogen temperature. All the experimental spectra of hemoglobin are composed of three doublets corresponding to oxy-hemoglobin (Oxy-Hb), deoxy-hemoglobin (Deoxy-Hb) and low-spin hemo-chrome (Ls-Hemo) respectively. It is found that Oxy-Hb is decreasing but Deoxy-hb increasing for diabetes. Experimental results also indicate that the line-width of Moessbauer spectra of Oxy-Hb for diabetics is narrower than that for normal adults, showing that while Fe on Oxy-Hb exists in pile-up of some similar states for normal adults, but it becomes in single state for serious diabetes

  3. Methylation of hemoglobin to enhance flocculant performance

    An inexpensive bioflocculant, bovine hemoglobin (Hb), has been covalently modified through methylation of the side chain carboxyl groups of aspartic and glutamic acid residues to improve its flocculation activity. Potentiometric titration of the recovered products showed approximately 28% degree of ...

  4. Cloned Hemoglobin Genes Enhance Growth Of Cells

    Khosla, Chaitan; Bailey, James E.

    1991-01-01

    Experiments show that portable deoxyribonucleic acid (DNA) sequences incorporated into host cells make them produce hemoglobins - oxygen-binding proteins essential to function of red blood cells. Method useful in several biotechnological applications. One, enhancement of growth of cells at higher densities. Another, production of hemoglobin to enhance supplies of oxygen in cells, for use in chemical reactions requiring oxygen, as additive to serum to increase transport of oxygen, and for binding and separating oxygen from mixtures of gases.

  5. Hemoglobin levels in normal Filipino pregnant women.

    Kuizon, M D; Natera, M G; Ancheta, L P; Platon, T P; Reyes, G D; Macapinlac, M P

    1981-09-01

    The hemoglobin concentrations during pregnancy in Filipinos belonging to the upper income group, who were prescribed 105 mg elemental iron daily, and who had acceptable levels of transferrin saturation, were examined in an attempt to define normal levels. The hemoglobin concentrations for each trimester followed a Gaussian distribution. The hemoglobin values equal to the mean minus one standard deviation were 11.4 gm/dl for the first trimester and 10.4 gm/dl for the second and third trimesters. Using these values as the lower limits of normal, in one group of pregnant women the prevalence of anemia during the last two trimesters was found lower than that obtained when WHO levels for normal were used. Groups of women with hemoglobin of 10.4 to 10.9 gm/dl (classified anemic by WHO criteria but normal in the present study) and those with 11.0 gm/dl and above could not be distinguished on the basis of their serum ferritin levels nor on the degree of decrease in their hemoglobin concentration during pregnancy. Many subjects in both groups, however, had serum ferritin levels less than 12 ng/ml which indicate poor iron stores. It might be desirable in future studies to determine the hemoglobin cut-off point that will delineate subjects who are both non-anemic and adequate in iron stores using serum ferritin levels as criterion for the latter.

  6. High affinity hemoglobin and Parkinson's disease.

    Graham, Jeffrey; Hobson, Douglas; Ponnampalam, Arjuna

    2014-12-01

    Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (SN) region of the midbrain. Oxidative damage in this region has been shown to play an important role in the pathogenesis of this disease. Human neurons have been discovered to contain hemoglobin, with an increased concentration seen in the neurons of the SN. High affinity hemoglobin is a clinical entity resulting from mutations that create a functional increase in the binding of hemoglobin to oxygen and an inability to efficiently unload it to tissues. This can result in a number of metabolic compensatory changes, including an elevation in circulating hemoglobin and an increase in the molecule 2,3-diphosphoglycerate (2,3-DPG). Population based studies have revealed that patients with PD have elevated hemoglobin as well as 2,3-DPG levels. Based on these observations, we hypothesize that the oxidative damage seen in PD is related to an underlying high affinity hemoglobin subtype. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Charge resolution of a Hungarian brand CR-39(MA-ND) detector exposed to a 84Kr beam of energy 0.45A GeV

    Bhattacharyya, D.P.; Basu, B.; Pal, P.; Mukherjee, S.C.; Ganguly, A.K.; Hunyady, I.

    1990-01-01

    The Hungarian brand CR-39(MA-ND) plastic has been irradiated with a 84 Kr ion beam of energy 0.45A GeV and etched for four different etching times, viz. 4, 6, 8 and 12 h. The estimated charge resolution of a CR-39(MA-ND) detector for registering the nuclei 32 ≤ Z ≤ 36 was found to be 0.18e which is close to our previous observation of the response with a CR-39(DOP) Pershore made plate exposed to a 1.88A GeV 56 Fe beam at the Lawrence Berkeley Laboratory's Bevalac. It was found that the estimated etch rate ratio V T /V G is independent of etching time. The cone length and minor axis of the etch pits has been found to increase with etching time. (orig.)

  8. Orthokeratinized odontogenic cyst: a report of two cases in the mandible = Cisto odontogênico ortoqueratinizado: relato de dois casos em mandíbula

    Pereira, Francisco de Assis Caldas

    2012-01-01

    Conclusão: Cisto odontogênico ortoqueratinizado deve ser considerado no diagnóstico diferencial das lesões que ocorrem na mandíbula associado com dentes impactados, especialmente aqueles casos que simulem o cisto dentígero. Além disso, observamos a importância de tomadas radiográficas antes do tratamento ortodôntico no diagnóstico de patologias bucais

  9. Saint John lateral pipeline project: comprehensive study report

    1999-02-01

    A descripion is given of the results of an environmental impact assessment of the construction of a natural gas pipeline that will bring gas from Maritimes and Northeast Pipeline Management Ltd.'s (M and NP) main transmission pipeline to clients in Lake Utopia and Saint John, NB. It will be 110 km long, and the Saint John lateral will join the mainline approximately 2 km south of Big Kedron Lake, NB. Various institutional, industrial, commercial and residential clients will be able to access the pipeline in the future, and it is intended to be capable of future expansion for markets along its route and for markets that become economically feasible in the future. A matrix was developed that relates environmental resources to Environmental Components of Concern (ECCs), and to the rationale for exclusion/inclusion of the ECC as a Valued Environmental Component (VECs). The positive benefits of the pipeline to clients in the Saint John area include: reduced dependence on foreign oil, fuel switching and price competition, lower air emission pollution, increased energy efficiency, and a source of energy that is secure and reliable. VECs were selected based on: concerns of various stakeholders including the public, community groups, scientific parties, Aboriginal groups, government officials and agencies, relevant regulations; relevant literature; and past evaluation experiences, including future developments of the proposed study area. Further selection of the VECs required an examination of the issues picked out via scoping to determine the ways in which the overall project could affect the ECCs, and included construction, operation, decommissioning/abandonment, malfunctions and accidents of the pipeline. The phases of the project as they impacted residually and cumulatively on the VECs were evaluated, and impacts on Valued Socio-Economic Components (VSCs) were assessed also. The mitigation efforts taken will minimize the potential effects of the project on VECs and VSCs

  10. [Saints and illnesses in faith and paleopathological evidences].

    Fulcheri, Ezio

    2006-01-01

    The exhumation of the natural mummies of Beata Margherita di Savoia (1390-1464) and of St. Caterina Fieschi Adorno (1447-1510) has not been followed by autopsy or histological exams. The aim has been to preserve the integrity of the saints' corpses. We have thus proceeded to a confrontation between data gathered from chronicles and hagiographies and radiological exams and macroscopic observations. The article aims at establishing a model for a multidisciplinar approach to paleopathological research, integrating historical research and medical knowledge.

  11. A reactivity accidents simulation of the Fort Saint Vrain HTGR

    Fainer, Gerson

    1980-01-01

    A reactivity accidents analysis of the Fort Saint Vrain HTGR was made. The following accidents were analysed 1) A rod pair withdrawal accident during normal operation, 2) A rod pair ejection accident, 3) A rod pair withdrawal accident during startup operations at source levels and 4) Multiple rod pair withdrawal accident. All the simulations were performed by using the BLOOST-6 nuclear code The steady state reactor operation results obtained with the code were consistent with the design reactor data. The numerical analysis showed that all accidents - except the first one - cause particle failure. (author)

  12. Facts and fiction: the death of Saint Ignatius of Loyola.

    Rosenman, L D

    1996-01-01

    The biography of Ignatius of Loyola, the sainted founder of the Society of Jesus (the Jesuits), ends with his death in curious circumstances. A careful search of the available sources written from the time of his death in 1556 to the present has reviewed the evidence. The evidence does not support the claims for a diagnosis that has been used for four centuries. So-called historical "facts" simply are the opinions of historians. Ignatius may have suffered from hyperparathyroidism that led to his death rather than from a cholangioportal venous fistula.

  13. Marketing analysis of brand Yves Saint Laurent in portfolio L´Oréal

    Petránková, Tereza

    2011-01-01

    The aim of this thesis Marketing analysis of brand Yves Saint Laurent in portfolio L'Oréal is analysis of brand Yves Saint Laurent. The theoretical part focuses mainly on marketing, brand, luxury, analysis of brand and marketing strategies. Practical part based on the findings in theoretical part analysed brand - history, indentity, value and marketing strategy and reccomend new marketing strategies.

  14. Colourful sparkles of imaginary vistas: Saintly beauty in the eyes of the beholder

    Dimitrova Elizabeta

    2013-01-01

    Full Text Available The article deals with the issue of physical appearance of the saintly images in Byzantine painting and the manners of its conception. In that regard, the paper offers categorization of the portraiture in which different saints receive distinctive aesthetic code appropriate to their type of “attractiveness”.

  15. Convergent evolution of hemoglobin switching in jawed and jawless vertebrates.

    Rohlfing, Kim; Stuhlmann, Friederike; Docker, Margaret F; Burmester, Thorsten

    2016-02-01

    During development, humans and other jawed vertebrates (Gnathostomata) express distinct hemoglobin genes, resulting in different hemoglobin tetramers. Embryonic and fetal hemoglobin have higher oxygen affinities than the adult hemoglobin, sustaining the oxygen demand of the developing organism. Little is known about the expression of hemoglobins during development of jawless vertebrates (Agnatha). We identified three hemoglobin switches in the life cycle of the sea lamprey. Three hemoglobin genes are specifically expressed in the embryo, four genes in the filter feeding larva (ammocoete), and nine genes correspond to the adult hemoglobin chains. During the development from the parasitic to the reproductive adult, the composition of hemoglobin changes again, with a massive increase of chain aHb1. A single hemoglobin chain is expressed constitutively in all stages. We further showed the differential expression of other globin genes: Myoglobin 1 is most highly expressed in the reproductive adult, myoglobin 2 expression peaks in the larva. Globin X1 is restricted to the embryo; globin X2 was only found in the reproductive adult. Cytoglobin is expressed at low levels throughout the life cycle. Because the hemoglobins of jawed and jawless vertebrates evolved independently from a common globin ancestor, hemoglobin switching must also have evolved convergently in these taxa. Notably, the ontogeny of sea lamprey hemoglobins essentially recapitulates their phylogeny, with the embryonic hemoglobins emerging first, followed by the evolution of larval and adult hemoglobins.

  16. Osteonecrose da mandíbula associada aos bifosfonatos em doentes com cancro do pulmão

    Inês Neves

    2013-09-01

    Full Text Available Resumo: A osteonecrose da mandíbula (ONM pode surgir como complicação do tratamento com bifosfonatos. Esta patologia tem sido descrita em doentes com cancro e o seu desenvolvimento associado a exposição prolongada a altas doses de bifosfonatos. Má higiene dentária, história de uso de próteses ou extração dentária, quimioterapia, corticosteroides e radioterapia da cabeça e pescoço são fatores de risco reportados. Nas fases iniciais pode ser assintomática, contudo, o doente posteriormente desenvolve dor significativa e exposição óssea progressiva. Os autores descrevem 3 casos de ONM em doentes com cancro do pulmão após exposição prolongada a bifosfonatos e na presença de fatores de risco conhecidos. A ONM pode atingir seriamente a qualidade de vida dos doentes com cancro. O diagnóstico precoce poderá reduzir ou mesmo evitar as consequências da lesão óssea progressiva. Abstract: Osteonecrosis of the jaw (ONJ can occur as a complication of bisphosphonate therapy. This condition has been described in cancer patients and its development has been associated with prolonged exposure to high doses of bisphosphonates. Bad dental hygiene, a history of prosthesis or dental extraction, chemotherapy, corticosteroids, and radiation therapy of the head and neck are risk factors reported. In the initial stages it may be asymptomatic, but the patient subsequently develops severe pain and progressive exposed bone. The authors describe three cases of ONJ in lung cancer patients after prolonged exposure to bisphosphonates and there were known risk factors. ONJ can seriously affect the quality of life of cancer patients. An early diagnosis may reduce or avoid the consequences of progressive bone lesion. Palavras-chave: Osteonecrose da mandíbula associada aos bifosfonatos, Cancro do pulmão, Fatores de risco, Tratamento, Keywords: Bisphosphonate-associated osteonecrosis of the

  17. The history of the missal directions of the All Saints Solemnity

    Jan Szczych

    2009-09-01

    Full Text Available The cult of the saints had its beginning in the Christian ancient times. Since then it was transformed in its own celebrations in honour of All the Saints. The official liturgy of the feast-day of Omnium Sanctorum (All Saints was stabilized in close relation to the development of collective worship of the saints in the West.  The historical liturgical witnesses from the Middle Ages and of the Trident Council time demonstrate a progressive and very natural process of establishment the missal texts of this liturgical celebration. The form of some liturgical directions in the current Missale Romanum (Latin Missal, unchanged for ages, confirms the continuity and constancy of this celebration in the history of Catholic Church. These missal directions explicitly show the same idea of celebration and timeless meaning of the All Saints Solemnity.

  18. Three saints with deformed extremities in an Italian Renaissance altarpiece.

    Albury, W R; Weisz, G M

    2017-03-01

    A fifteenth-century Florentine altarpiece painted by the Pollaiuolo brothers, Antonio (1433-1498) and Piero (1443-1496), shows three saints with evident deformities of the hands and feet. The pathologies concerned are tentatively identified, and various rationales for their presence in the painting are discussed. Of particular importance is the location of the altarpiece in a chapel which houses the tomb of the Cardinal of Portugal, Prince James of Lusitania (1433-1459). It is argued that both the artistic style of the day and the religious symbolism of the Cardinal's funeral chapel contributed to the artists' decision to portray the saints with deformities. An unnatural curvature of the fifth finger was apparently considered elegant in fifteenth-century paintings, and the depiction of bare feet with hallux valgus gave them a shape which approximated and could have been caused by fashionable pointed shoes. But in addition, deformities in religious art could be symbolic of suffering and martyrdom, a theme which the Cardinal's chapel emphasised in a number of ways. It is suggested therefore that the Pollaiuolo altarpiece reconciles these two disparate factors, portraying genuine deformities in a way that was artistically stylish and symbolically meaningful.

  19. Nitrosyl hemoglobins: EPR above 80 K

    Wajnberg, E.; Bemski, G.; El-Jaick, L.J.; Alves, O.C.

    1995-03-01

    The EPR spectra of nitrosyl hemoglobin and myoglobin in different conditions (native, denatured and lyophilized), as well as of hematin-NO were obtained in the temperature range of 80 K-280 K. There is a substantial and reversible.decrease of the areas of the EPR spectra of all the hemoglobin samples above 150 K. The interpretation of the results implies the existence of two conformational states in thermal equilibrium only one of which is EPR detectable. Thermodynamical parameters are determined for the hexa and penta-coordinated cases. (author). 25 refs, 3 figs.

  20. Nitrosyl hemoglobins: EPR above 80 K

    Wajnberg, E.; Bemski, G.; El-Jaick, L.J.; Alves, O.C.

    1995-03-01

    The EPR spectra of nitrosyl hemoglobin and myoglobin in different conditions (native, denatured and lyophilized), as well as of hematin-NO were obtained in the temperature range of 80 K-280 K. There is a substantial and reversible.decrease of the areas of the EPR spectra of all the hemoglobin samples above 150 K. The interpretation of the results implies the existence of two conformational states in thermal equilibrium only one of which is EPR detectable. Thermodynamical parameters are determined for the hexa and penta-coordinated cases. (author). 25 refs, 3 figs

  1. Estética del 'cross a la mandíbula' y elementos modernista - decadentes en Roberto Arlt

    Laura Susana Juárez

    2003-11-01

    Full Text Available El trabajo reflexiona sobre el cruce de tendencias presentes en lo que se ha considerado como la primera etapa de la obra de Roberto Arlt. Así, en la estética arltiana de una literatura que encierra “la viol encia de un ‘cross’ a la mandíbula”, definida en las palabras preliminares a Los lanzallamas, se introducen algunos rasgos que provienen del modernismo y del imaginario decadente, en muchos aspectos, muy criticados por el propio escritor. En este marco, se analiza, en primer lugar, “Jehová” (1918, el primer cuento que publicó, cuya construcción evidencia lecturas de fuerte matriz modernista. Luego, se estudia el modo en que Arlt intenta separarse del modernismo-decadentismo en sus textos programáticos, sus novelas y sus primeras narraciones, y la forma en que, de todas maneras, se retoman en su literatura ciertos elementos que remiten visiblemente a la estética en cuestión. Finalmente, indagamos cómo, cuando en Arlt puede observarse una pretensión de “estilo alto”, aparece el modernismo

  2. Thinking with the saint: the miracle of Saint Januarius of Naples and science in early modern Europe.

    de Ceglia, Francesco Paolo

    2014-01-01

    The aim of this paper is to reconstruct the way in which early modem science questioned and indirectly influenced (while being in its turn influenced by) the conceptualization of the liquefaction of the blood of Saint Januarius, a phenomenon that has been taking place at regular intervals in Naples since the late Middle Ages. In the seventeenth century, a debate arose that divided Europe between supporters of a theory of divine intervention and believers in the occult properties of the blood. These two theoretical options reflected two different perspectives on the relationship between the natural and the supernatural. While in the seventeenth century, the emphasis was placed on the predictable periodicity of the miraculous event of liquefaction as a manifestation of God in his role as a divine regulator, in the eighteenth century the event came to be described as capricious and unpredictable, in an attempt to differentiate miracles from the workings of nature, which were deemed to be normative. The miracle of the blood of Saint Januarius thus provides a window through which we can catch a glimpse of how the natural order was perceived in early modern Europe at a time when the Continent was culturally fragmented into north and south, Protestantism and Catholicism, learned and ignorant.

  3. Public meeting of September 13, 2005 at Saint-Dizier; Reunion publique du 13 septembre 2005 a Saint-Dizier

    NONE

    2005-07-01

    The law from December 30, 1991, precisely defines 3 axes of researches for the management of high level and long-lived radioactive wastes: separation/transmutation, surface storage and underground disposal. A global evaluation report about these researches is to be supplied in 2006 by the French government to the Parliament. A first synthesis of the knowledge gained after 14 years of research has led the national commission of the public debate (CNDP) to organize a national debate about the general options of management of high-level and long-lived radioactive wastes before the 2006 date line. The debate comprises 4 public hearings (September 2005: Bar-le-Duc, Saint-Dizier, Pont-du-Gard, Cherbourg), 12 round-tables (October and November 2005: Paris, Joinville, Caen, Nancy, Marseille), a synthesis meeting (December 2005, Dunkerque) and a closing meeting (January 2006, Lyon). This document is the synthesis of the debates of the second public hearing at Saint-Dizier. This meeting gathers representatives of the different actors of the nuclear industry, ministers, public authorities, non governmental organizations who argue the questions asked by peoples from the audience. The topics concern the safety aspects of waste facilities, in particular according to the studies carried out at the Bure site, the different categories of wastes and the future wastes that will be generated by the dismantling of nuclear facilities etc. (J.S.)

  4. The implantation of a PV electric energy generation system at the Saint Peter and Saint Paul islands

    Galdino, Marco Antonio; Silva, Patricia de Castro da [Centro de Pesquisas de Energia Eletrica (CEPEL), Rio de Janeiro, RJ (Brazil)], E-mail: marcoag@cepel.br; Souza, Marco Antonio Carvalho [Secretaria da Comissao Interministerial para os Recursos do Mar (SECIRM), Brasilia, DF (Brazil)

    2009-07-01

    The Saint Peter and Saint Paul Islands are located at 0 degree 55.00' N and 29 degree 20.76'' W, at a distance of circa 550 M (nautical miles) NE from the City of Natal, RN (Northeast Region of Brazil), and comprises of many small islands and rocks of igneous plutonic origin. In 1998, a first Scientific Station was built in order to receive researchers involved in several projects. The CEPEL, as responsible by the electrical energy supply to the Scientific Station; designed and installed a PV electric energy generation system which had a power of 3.6 kWp. This system operated successfully for the last 10 years, suffering frequent maintenance. In 2006, a new design for the Scientific Station has been started aiming to improve its resources and safety. The new PV system has a maximum power of 7.8 kWp, and employs an updated technology (SMA, Germany). The equipment was integrated and submitted to intensive testing at facilities of CEPEL, and was installed and commissioned at the Islands in June 2008. Since the installation, the equipment has been operating as required, meeting the energy and water demand of the Station. The present paper describes the many steps involved in the implantation of the PV system at the Scientific Station. (author)

  5. Compressive strength evolution of thermally-stressed Saint Maximin limestone.

    Farquharson, J.; Griffiths, L.; Baud, P.; Wadsworth, F. B.; Heap, M. J.

    2017-12-01

    The Saint Maximin quarry (Oise, France) opened in the early 1600s, and its limestone has been used extensively as masonry stone, particularly during the classical era of Parisian architecture from the 17th century onwards. Its widespread use has been due to a combination of its regional availability, its high workability, and its aesthetic appeal. Notable buildings completed using this material include sections of the Place de la Concorde and the Louvre in Paris. More recently, however, it has seen increasing use in the construction of large private residences throughout the United States as well as extensions to private institutions such as Stanford University. For any large building, fire hazard can be a substantial concern, especially in tectonically active areas where catastrophic fires may arise following large-magnitude earthquakes. Typically, house fires burn at temperatures of around 600 °C ( 1000 F). Given the ubiquity of this geomaterial as a building stone, it is important to ascertain the influence of heating on the strength of Saint Maximin limestone (SML), and in turn the structural stability of the buildings it is used in. We performed a series of compressive tests and permeability measurements on samples of SML to determine its strength evolution in response to heating to incrementally higher temperatures. We observe that the uniaxial compressive strength of SML decreases from >12 MPa at room temperature to 400 °C). We anticipate that this substantial weakening is in part a result of thermal microcracking, whereby changes in temperature induce thermal stresses due to a mismatch in thermal expansion between the constituent grains. This mechanism is compounded by the volumetric increase of quartz through its alpha - beta transition at 573 °C, and by the thermal decomposition of calcite. To track the formation of thermal microcracks, we monitor acoustic emissions, a common proxy for microcracking, during the heating of an SML sample. The

  6. Predictors of hemoglobin in Danish blood donors

    Kotzé, Sebastian R; Pedersen, Ole B; Petersen, Mikkel S

    2015-01-01

    BACKGROUND: It is well known that blood donors are at increased risk of iron deficiency and subsequent development of iron deficiency anemia. We aimed to investigate the effect of factors influencing hemoglobin (Hb) levels. STUDY DESIGN AND METHODS: Initiated in 2010, the Danish Blood Donor Study...

  7. Rheological Variations among Nigerians with Different Hemoglobin ...

    Some Hemorheological determinants such as whole blood viscosity (WBV) and plasma viscosity (PV) and Plasma Fibrinogen Concentration (PFC) were measured with standard methods. We recorded a relatively unchanged whole blood viscosities in subjects with various hemoglobin genotypes (AA, AS and SS; P>0.05, ...

  8. High-altitude adaptations in vertebrate hemoglobins

    Weber, Roy E.

    2007-01-01

    Vertebrates at high altitude are subjected to hypoxic conditions that challenge aerobic metabolism. O2 transport from the respiratory surfaces to tissues requires matching between the O2 loading and unloading tensions and theO2-affinity of blood, which is an integrated function of hemoglobin......, birds and ectothermic vertebrates at high altitude....

  9. Constraints on mutational pathways of hemoglobin evolution

    Kumar, Amit; Natarajan, Chandrasekhar; Moriyama, Hideaki

    2016-01-01

    amino acid substitutions that occurred during an evolutionary reduction in hemoglobin (Hb)-O2 affinity in nightjars (nocturnal birds in the family Caprimulgidae).We selected nightjar Hbs for experimental study because ancestral sequence reconstructions indicated that the evolved reduction in Hb-O2...

  10. Kadar Hemoglobin dan Kecerdasan Intelektual Anak

    Yuni Kusmiyati

    2013-10-01

    Full Text Available Kualitas sumber daya manusia dipengaruhi oleh inteligensi anak. Skor kecerdasan intelektual yang tidak menetap pada usia tertentu dapat berubah karena faktor genetik, gizi, dan lingkungan. Tujuan penelitian ini adalah mengetahui hubungan kadar hemoglobin dengan kecerdasan intelektual anak. Penelitian observasional dengan desain potong lintang ini dilakukan pada populasi siswa kelas VI Sekolah Dasar Negeri Giwangan Yogyakarta, tahun 2013. Penarikan sampel dilakukan dengan metode simple random sampling terhadap 37 sampel siswa. Instrumen untuk mengukur kecerdasan intelektual dengan Cultural Fair Intelligence Quotient Test yang dirancang untuk meminimalkan pengaruh kultural dengan memperhatikan prosedur evaluasi, instruksi, konten isi, dan respons peserta. Tes dilakukan oleh Biro Psikologi Universitas Ahmad Dahlan Yogyakarta, kadar hemoglobin diukur menggunakan Portable Hemoglobin Digital Analyzer Easy Touch secara digital.Variabel luar indeks massa tubuh diukur langsung menggunakan parameter tinggi badan dan berat badan. Analisis menggunakan uji regresi linier. Hasil penelitian menunjukkan indeks massa tubuh tidak berhubungan dengan kecerdasan intelektual (nilai p = 0,052. Anemia berhubungan cukup dengan kecerdasan anak (r = 0,491 dan berpola positif, semakin tinggi kadar hemoglobin semakin tinggi kecerdasan intelektual anak. Nilai koefisien determinasi 0,241 menerangkan bahwa 24,1% variasi anemia cukup baik untuk menjelaskan variabel kecerdasan intelektual. Ada hubungan antara kadar hemoglobin dengan kecerdasan intelektual (nilai p = 0,002. Quality of human resources is influenced by the child’s intelligent. Intelligence Quotient (IQ score will not settle at a certain age and can change due to genetic factors, nutrition, and the environment. The objective is known relationship of anemia with IQ to child. Method of observational study with cross sectional design. Population are students of class VI elementary school of Giwangan Yogyakarta in

  11. A second level of the Saint Petersburg skyline

    Krasnopolsky, Andrey; Bolotin, Sergey

    2018-03-01

    The article considers the history of the residential development in Saint Petersburg and states corresponding landmark dates. In recent years, changes in the altitude range of the residential development are noted, the influence of this factor on the formation of the city's silhouette is assessed. Reasons for such changes are identified. Attractiveness of high-rise residential complexes for living is assessed. Conclusions are made of tendencies in further housing construction development in terms of its altitude range. It is noted that it is possible to locate multi-storied buildings in the periphery of the city, taking into account specific visual characteristics of the construction site and silhouette of erected buildings; as for central districts, strict regulations regarding the altitude range are needed.

  12. How did Death become a Saint in Mexico?

    Kristensen, Regnar Albæk

    2014-01-01

    Over the last decade, the cult of La Santa Muerte (St Death) has attracted a remarkable number of followers in Mexico and the USA. Whereas the social context of her devotees, who tend to live on the fringes of society, has attracted ample attention from scholars and journalists, one of the princi......Over the last decade, the cult of La Santa Muerte (St Death) has attracted a remarkable number of followers in Mexico and the USA. Whereas the social context of her devotees, who tend to live on the fringes of society, has attracted ample attention from scholars and journalists, one...... of the principal puzzles is still how a skeleton image of death has come to be seen as a saint by large numbers of Catholics. How is it possible for this figure to embrace such antagonistic qualities as death and sainthood in a Christian context? In this semiotic-material exploration of the image’s genealogy, I...

  13. The economics of geothermal power in Saint Lucia, West Indies

    Barthelmy, A.

    1990-01-01

    This paper reports on an economic comparison which is made between geothermal power at Sulphur Springs, Soufriere, Saint Lucia and diesel generated power from a new diesel power station at Cul de Sac to the south of Castries. The comparison is over a 20 year period. The new diesel power station is scheduled for commission during the second half of 1990. The capital costs for the Cul de Sac Station are based on actual contract sums for Stage I of the development program, comprising 2 x 6.3 MW generating units. Development costs for a 2 x 5.6 MW dry steam geothermal power plant are based on actual well costs and estimated costs for the steam gathering system and power plant. The geothermal reservoir is assumed to be vapor dominated. Levelized coatings will be adopted for comparing the total generating costs in cents per kilowatt hour associated with the two generating plants

  14. Segmented Aperture Interferometric Nulling Testbed (SAINT) II: component systems update

    Hicks, Brian A.; Bolcar, Matthew R.; Helmbrecht, Michael A.; Petrone, Peter; Burke, Elliot; Corsetti, James; Dillon, Thomas; Lea, Andrew; Pellicori, Samuel; Sheets, Teresa; Shiri, Ron; Agolli, Jack; DeVries, John; Eberhardt, Andrew; McCabe, Tyler

    2017-09-01

    This work presents updates to the coronagraph and telescope components of the Segmented Aperture Interferometric Nulling Testbed (SAINT). The project pairs an actively-controlled macro-scale segmented mirror with the Visible Nulling Coronagraph (VNC) towards demonstrating capabilities for the future space observatories needed to directly detect and characterize a significant sample of Earth-sized worlds around nearby stars in the quest for identifying those which may be habitable and possibly harbor life. Efforts to improve the VNC wavefront control optics and mechanisms towards repeating narrowband results are described. A narrative is provided for the design of new optical components aimed at enabling broadband performance. Initial work with the hardware and software interface for controlling the segmented telescope mirror is also presented.

  15. Saint-Laurent-des-Eaux nuclear facilities. 2009 annual report

    2010-01-01

    This annual report is established on account of article 21 of the 2006-686 French law from June 13, 2006, relative to the transparency and safety in the nuclear domain. It describes, first, the nuclear facilities of Saint-Laurent-des-Eaux, and then the measures taken to ensure their safety (personnel radioprotection, actions implemented for nuclear safety improvement, organisation in crisis situation, external and internal controls, technical assessment of the facilities, administrative procedures carried out in 2009), incidents and accidents registered in 2009, radioactive and chemical effluents released by the facilities in the environment, other pollutions, management of radioactive wastes, and, finally, the actions carried out in the domain of transparency and public information. A glossary and the viewpoint of the Committee of Hygiene, safety and working conditions about the content of the document conclude the report. (J.S.)

  16. Centro Federal de Comunidad Saint Louis - EE.UU.

    Hellmuth, George

    1980-04-01

    Full Text Available The Community Federal Center lies in the outskirts of the town of Saint Louis. It was conceived and designed by the project authors — in a style characteristic of them — as a suburban architectonic complex for office use. The work, standing out over an open stretch of land, has an ample base, with a volume that is neither the actual tower of the city centre nor the classic low rural construction. The building's architectonic language permits an integration, by sympathy, in the context of the neighbouring uni-family housing zone, without naturally being assimilated in them, due to the disparity of functions. It is achieved through a fracture of scaled volumes, breaking the classic coldness of the big office building, whilst at the same time thanks to its robustness, it indicates the activity housed inside.

    El Community Federal Center está emplazado en las afueras de la ciudad de Saint Louis. Fue concebido y diseñado por los autores del proyecto —en un estilo que les es característico—, como un complejo arquitectónico suburbano destinado a oficinas. La obra, que se eleva sobre un terreno despejado, es amplía de base, presentando un volumen que no es ni la torre propia del centro urbano ni la clásica construcción rural de baja altura. El lenguaje arquitectónico del edificio permite una integración, por simpatía, en el contexto de la zona de viviendas unifamiliares cercana, sin llegar, naturalmente, a asimilarse a ellas dada la disparidad de funciones. Se lleva a cabo por medio de una fractura de volúmenes, escalonados, que rompen la frialdad clásica del gran edificio de oficinas, sin dejar de indicar, por su robustez, la actividad que alberga en su interior.

  17. A new hemoglobin gene from soybean: a role for hemoglobin in all plants

    Anderson, C R; Jensen, E O; LLewellyn, D J

    1996-01-01

    We have isolated a new hemoglobin gene from soybean. It is expressed in cotyledons, stems of seedlings, roots, young leaves, and in some cells in the nodules that are associated with the nitrogen-fixing Bradyrhizobium symbiont. This contrasts with the expression of the leghemoglobins, which...... are active only in the infected cells of the nodules. The deduced protein sequence of the new gene shows only 58% similarity to one of the soybean leghemoglobins, but 85-87% similarity to hemoglobins from the nonlegumes Parasponia, Casuarina, and barley. The pattern of expression and the gene sequence...... indicate that this new gene is a nonsymbiotic legume hemoglobin. The finding of this gene in legumes and similar genes in other species strengthens our previous suggestion that genomes of all plants contain hemoglobin genes. The specialized leghemoglobin gene family may have arisen from a preexisting...

  18. Who is Jesus Christ for the Ruthenian and Russian Saints? A Theological Exploration of St Dimitry Rostovsky’s The Lives of the Saints

    Krzysztof Leśniewski

    2014-12-01

    Full Text Available Christian hagiography reveals not only the facts of life of individual saints, but first of all, it is a description of theexperience of God loving mankind. From the beginning of Christianity, of great importance in building faith, hope andlove had had stories about those believers who responded with a particular radicalism for the prevenient love of God inthe Trinity of Persons. These stories have been written in various forms of literature.Author in the introductory part of the article introduces into the lives of the saints and their role in the Ruthenian andRussian Orthodoxy. Essentially he focuses on presenting The Menaia edited by St Dimitry Rostovski. This book waspublished in the years 1711 to 1718 in Old Church Slavonic. At the beginning of the twentieth century, it has been rewrittenand translated into Russian. This monumental work appeared in the years 1903-1911 under the title The Lives of theSaints. It has been a rich source of information for researchers from many disciplines.From a theological point of view, the author studied The Lives of the Saints in order to find direct references to theperson and teaching of Jesus Christ. For this purpose, he analyzed quotations from the New Testament, especially fromthe Gospel, referring directly to the Person and teaching of Jesus Christ, as well as the prayers addressed to Him. In hisanalysis, he searched for answers to the questions: Who is Jesus Christ for the Ruthenian and Russian saints, and whatkind of His images predominate in The Lives of the Saints.The first part of the article, on the basis of source texts, indicates personal qualities of Jesus Christ. The Savior hasbeen experienced by the Ruthenian and Russian saints as God who is close to man, the blessed King, the best Lord, theComforter of the crying, the Light, the merciful God, and the Foundation of all good. The image of Christ as sinless,innocent suffering and merciful shines especially in the devotion of Saints Passion

  19. Alpha chain hemoglobins with electrophoretic mobility similar to that of hemoglobin S in a newborn screening program

    Marcilene Rezende Silva

    2013-01-01

    Full Text Available OBJECTIVE: To characterize alpha-chain variant hemoglobins with electric mobility similar to that of hemoglobin S in a newborn screening program. METHODS: βS allele and alpha-thalassemia deletions were investigated in 14 children who had undefined hemoglobin at birth and an electrophoretic profile similar to that of hemoglobin S when they were six months old. Gene sequencing and restriction enzymes (DdeI, BsaJI, NlaIV, Bsu36I and TaqI were used to identify hemoglobins. Clinical and hematological data were obtained from children who attended scheduled medical visits. RESULTS: The following alpha chain variants were found: seven children with hemoglobin Hasharon [alpha2 47(CE5 Asp>His, HbA2:c.142G>C], all associated with alpha-thalassemia, five with hemoglobin Ottawa [alpha1 15(A13 Gly>Arg, HBA1:c.46G>C], one with hemoglobin St Luke's [alpha1 95(G2 Pro>Arg, HBA1:c.287C>G] and another one with hemoglobin Etobicoke [alpha212 84(F5 Ser>Arg, HBA212:c.255C>G]. Two associations with hemoglobin S were found: one with hemoglobin Ottawa and one with hemoglobin St Luke's. The mutation underlying hemoglobin Etobicoke was located in a hybrid α212 allele in one child. There was no evidence of clinically relevant hemoglobins detected in this study. CONCLUSION: Apparently these are the first cases of hemoglobin Ottawa, St Luke's, Etobicoke and the α212 gene described in Brazil. The hemoglobins detected in this study may lead to false diagnosis of sickle cell trait or sickle cell disease when only isoelectric focusing is used in neonatal screening. Additional tests are necessary for the correct identification of hemoglobin variants.

  20. Alpha chain hemoglobins with electrophoretic mobility similar to that of hemoglobin S in a newborn screening program.

    Silva, Marcilene Rezende; Sendin, Shimene Mascarenhas; Araujo, Isabela Couto de Oliveira; Pimentel, Fernanda Silva; Viana, Marcos Borato

    2013-01-01

    To characterize alpha-chain variant hemoglobins with electric mobility similar to that of hemoglobin S in a newborn screening program. β(S) allele and alpha-thalassemia deletions were investigated in 14 children who had undefined hemoglobin at birth and an electrophoretic profile similar to that of hemoglobin S when they were six months old. Gene sequencing and restriction enzymes (DdeI, BsaJI, NlaIV, Bsu36I and TaqI) were used to identify hemoglobins. Clinical and hematological data were obtained from children who attended scheduled medical visits. THE FOLLOWING ALPHA CHAIN VARIANTS WERE FOUND: seven children with hemoglobin Hasharon [alpha2 47(CE5) Asp>His, HbA2:c.142G>C], all associated with alpha-thalassemia, five with hemoglobin Ottawa [alpha1 15(A13) Gly>Arg, HBA1:c.46G>C], one with hemoglobin St Luke's [alpha1 95(G2) Pro>Arg, HBA1:c.287C>G] and another one with hemoglobin Etobicoke [alpha212 84(F5) Ser>Arg, HBA212:c.255C>G]. Two associations with hemoglobin S were found: one with hemoglobin Ottawa and one with hemoglobin St Luke's. The mutation underlying hemoglobin Etobicoke was located in a hybrid α212 allele in one child. There was no evidence of clinically relevant hemoglobins detected in this study. Apparently these are the first cases of hemoglobin Ottawa, St Luke's, Etobicoke and the α212 gene described in Brazil. The hemoglobins detected in this study may lead to false diagnosis of sickle cell trait or sickle cell disease when only isoelectric focusing is used in neonatal screening. Additional tests are necessary for the correct identification of hemoglobin variants.

  1. The effect of heart-and kidney-Benefiting Chinese Herbal Medicine on the function of cholinergic M-and Gamma amino-butyric acid (GABA) receptor in brain tissues of analogue dementia rats

    Mo Qizhong; Gong Bin; Fang Jun

    1993-01-01

    3 H-QNB and 3 H-GABA were used as radioactive ligand for M-and GABA receptors respectively. M-and GABA receptors were assayed by radioligand binding assay (RBA) in cerebral cortex, hippocampus and cerebellum of analogue dementia rats. It was found that R t of M receptor was decreased in cerebral cortex and hippocampus and R t of GABA receptor was decreased in cerebellum of analogue dementia rats. The dissociation constant (K D ) of M-receptor was decreased significantly in cerebral cortex and K D value of (GABA) receptor was decreased in cerebellum of analogue dementia rats. The decreased R t of M-and GABA receptor in brain tissue of analogue dementia rats was raised by Heart- and Kidney-Benefiting Chinese Herbs as well as hydergin

  2. The effect of heart-and kidney-Benefiting Chinese Herbal Medicine on the function of cholinergic M-and Gamma amino-butyric acid (GABA) receptor in brain tissues of analogue dementia rats

    Qizhong, Mo; Bin, Gong; Jun, Fang [Shanghai College of TCM, Shanghai (China); and others

    1993-05-01

    [sup 3]H-QNB and [sup 3]H-GABA were used as radioactive ligand for M-and GABA receptors respectively. M-and GABA receptors were assayed by radioligand binding assay (RBA) in cerebral cortex, hippocampus and cerebellum of analogue dementia rats. It was found that R[sub t] of M receptor was decreased in cerebral cortex and hippocampus and R[sub t] of GABA receptor was decreased in cerebellum of analogue dementia rats. The dissociation constant (K[sub D]) of M-receptor was decreased significantly in cerebral cortex and K[sub D] value of (GABA) receptor was decreased in cerebellum of analogue dementia rats. The decreased R[sub t] of M-and GABA receptor in brain tissue of analogue dementia rats was raised by Heart- and Kidney-Benefiting Chinese Herbs as well as hydergin.

  3. Variación en la forma de la mandíbula en Monophyllus redmani (Chiroptera: Phyllostomidae): análisis geométrico de la variación sexual y geográfica

    Mancina, Carlos A.; Balseiro, Fernando

    2010-01-01

    Analizamos la variación sexual y geográfica en la forma de la mandíbula de Monophyllus redmani mediante métodos de morfometría geométrica. Las diferencias en el tamaño y la forma de la mandíbula fueron examinadas usando 10 "landmarks" o puntos de referencia sobre la vista lateral de la mandíbula de 69 individuos. La significación de la variación de la forma entre sexos y regiones geográficas fue analizada mediante un análisis múltiple de varianza de dos vías sobre la matriz de las variables d...

  4. Les couleurs de Moscou et de Saint-Pétersbourg The colours of Moscow and Saint Petersburg

    Andréi Éfimov

    2008-05-01

    Full Text Available Moscou et Saint-Pétersbourg ont connu une évolution chromatique similaire mais les différences en matière de plan, d’urbanisme et d’influences culturelles, et leurs rôles alternés de capitale ont déterminé leurs particularités chromatiques propres. Le Moscou en bois du xiiie siècle s’est enrichi d’un ensemble de cathédrales blanches aux coupoles dorées entourées par la muraille en brique rouge du Kremlin. Le style baroque a introduit dans l’architecture de Moscou et de Saint-Pétersbourg les couleurs bleu foncé, orange et verte. À l’époque du classicisme, on utilisait la palette officielle de teintes pastel à dominante ocre. L’achromatisme devient ensuite un trait distinctif de l’éclectisme en Russie. Au début du XXe siècle, l’Art nouveau ranime les villes grâce aux couleurs verte, orange et violette. Dans les années 1920 et 1930, les constructivistes utilisent les tons gris mais tentent d’élaborer un code chromatique homogène. L’architecture soviétique, quant à elle, reprend l’esthétique du classicisme « ocre ». La construction de masse des années 1960 aux années 1980 méconnaît la couleur, mais à la charnière des XXe et XXIe siècles apparaissent des approches professionnelles qui visent à créer un milieu chromatique similaire pour les deux villes.Moscow and Saint Petersburg experienced similar evolutions in colour, but the differences in their plans, urbanity and cultural influences, and their alternating roles as capitals, determined the particularities of their palettes. The wooden Moscow of the thirteenth century was enriched by a group of white cathedrals with golden domes, surrounded by the red brick wall of the Kremlin. Baroque, as an architectural style, introduced Moscow and Saint Petersburg to the colours dark blue, orange, and green. The official palette of classicism was pastel, predominantly ochre, while the period of eclecticism in Russia was achromatic. At the

  5. Lyophilized bovine hemoglobin as a possible reference material for the determination of hemoglobin derivatives in human blood

    Maas, BHA; Buursma, A; Ernst, RAJ; Maas, AHJ; Zijlstra, WG

    1998-01-01

    We investigated the suitability of a lyophilized bovine hemoglobin (LBH) preparation containing various fractions of oxyhemoglobin (O(2)Hb), carboxyhemoglobin (COHb), and methemoglobin (MetHb) for quality assessment in multicomponent analysis (MCA) of hemoglobin derivatives. It was demonstrated that

  6. Lyophilized bovine hemoglobin as a possible reference material for the determination of hemoglobin derivatives in human blood

    Maas, BHA; Buursma, A; Ernst, RAJ; Maas, AHJ; Zijlstra, WG

    We investigated the suitability of a lyophilized bovine hemoglobin (LBH) preparation containing various fractions of oxyhemoglobin (O(2)Hb), carboxyhemoglobin (COHb), and methemoglobin (MetHb) for quality assessment in multicomponent analysis (MCA) of hemoglobin derivatives. It was demonstrated that

  7. Fibro-odontoma ameloblástico de la mandíbula Ameloblastic fibro-odontoma of the jaw

    María Loreto Castellón

    2013-06-01

    Full Text Available El fibro-odontoma ameloblástico (FOA es un tumor odontogénico poco frecuente que afecta a personas jóvenes, sin predilección por género y usualmente se localiza en la zona posterior de la mandíbula. Clínicamente el paciente puede presentar retraso en la erupción dentaria acompañado de aumento de volumen indoloro. Radiográficamente es una lesión radiolúcida uni o multilocular de tamaño variable con áreas radiopacas. El tratamiento varía de acuerdo a su tamaño y se debe tener especial cuidado en la decisión de conservar o no los dientes adyacentes, ya que existe la posibilidad de recurrencia de la lesión. Presentamos un caso de FOA de gran tamaño en un paciente de 4 años. Se describen las características específicas, histológicas y clínicas. Se discute en la conducta terapéutica conservadora y la necesidad de control postoperatorio prolongado en el tiempo.Ameloblastic fibro-odontoma (AFO is an infrequent odontogenic tumor that affects young people of either sex and is usually located in the posterior mandibular zone. Clinically, the patient might present a delay in dental eruption with a painless increase in volume. Radiographically, it is a uni- or multilocular radiolucent lesion of variable size with radiopaque areas. Treatment varies with tumor size and the decision to conserve the adjacent teeth must be weighed carefully due to the possibility of recurrence. The case of a large AFO in a 4-year-old patient is reported. The specific histological and clinical characteristics are described and the conservative therapy and need for long-term postoperative follow-up are discussed.

  8. Determinação do sexo e estimativa da idade por meio de mensurações em mandíbulas secas de adultos

    Victor Magalhães Santos Pinto

    2017-09-01

    Full Text Available A Odontologia Legal exerce um papel importante no processo de identificação de indivíduos, principalmente, quando é recebido para o processo de análise, o crânio da vítima. Este possui estruturas particulares que podem fornecer dados suficientes para a determinação do sexo de um indivíduo. Outra estrutura que também demonstra características seguras é a mandíbula. O objetivo desse trabalho foi determinar as características diferenciais entre partes de crânios pertencentes a indivíduos do sexo masculino e feminino, de diferentes idades, por meio da análise das distâncias entre os processos coronóides e as distâncias interbasal da língula em mandíbula seca. A pesquisa foi realizada no Laboratório de Anatomia na Universidade UNIME, utilizando-se 160 mandíbulas, sendo 81 do sexo feminino e 79 do sexo masculino, compreendidas entre a faixa etária de 21 a 95 anos. As amostras estudadas foram de pessoas indigentes cujas famílias não reclamaram os ossos no tempo hábil administrativo estabelecido pelo cemitério, iriam ser incinerados e pertencem atualmente ao Laboratório. De acordo com a análise estatística, houve um índice de acerto de 78,9% por regressão logística e 71,26% por análise discriminante. Houve também a verificação da média e do intervalo de confiança utilizando o teste t e a regressão linear múltipla para a predição da idade, evidenciando que o modelo não foi significativo (p = 0,4631. Após análises das mandíbulas secas, conseguiu-se validar as distâncias do processo coronóide aos sexos referidos.

  9. Estimativa do sexo através de características métricas da mandíbula

    Alves, Carina Filipa Pinto

    2012-01-01

    Dissertação de mestrado em Medicina (Medicina Legal e Ciências Forenses), apresentada à Faculdade de Medicina da Universidade de Coimbra A diagnose sexual a partir da análise de restos ósseos humanos é um elemento capital na investigação forense. Um grande número de estudos tem mostrado a existência de dimorfismo sexual em quase todos os ossos do esqueleto humano. A mandíbula humana adulta é um elemento do esqueleto particularmente robusto, sólido e usualmente preservado em contextos foren...

  10. Hemoglobin estimation by the HemoCue® portable hemoglobin photometer in a resource poor setting.

    Nkrumah, Bernard; Nguah, Samuel Blay; Sarpong, Nimako; Dekker, Denise; Idriss, Ali; May, Juergen; Adu-Sarkodie, Yaw

    2011-04-21

    In resource poor settings where automated hematology analyzers are not available, the Cyanmethemoglobin method is often used. This method though cheaper, takes more time. In blood donations, the semi-quantitative gravimetric copper sulfate method which is very easy and inexpensive may be used but does not provide an acceptable degree of accuracy. The HemoCue® hemoglobin photometer has been used for these purposes. This study was conducted to generate data to support or refute its use as a point-of-care device for hemoglobin estimation in mobile blood donations and critical care areas in health facilities. EDTA blood was collected from study participants drawn from five groups: pre-school children, school children, pregnant women, non-pregnant women and men. Blood collected was immediately processed to estimate the hemoglobin concentration using three different methods (HemoCue®, Sysmex KX21N and Cyanmethemoglobin). Agreement between the test methods was assessed by the method of Bland and Altman. The Intraclass correlation coefficient (ICC) was used to determine the within subject variability of measured hemoglobin. Of 398 subjects, 42% were males with the overall mean age being 19.4 years. The overall mean hemoglobin as estimated by each method was 10.4 g/dl for HemoCue, 10.3 g/dl for Sysmex KX21N and 10.3 g/dl for Cyanmethemoglobin. Pairwise analysis revealed that the hemoglobin determined by the HemoCue method was higher than that measured by the KX21N and Cyanmethemoglobin. Comparing the hemoglobin determined by the HemoCue to Cyanmethemoglobin, the concordance correlation coefficient was 0.995 (95% CI: 0.994-0.996, p < 0.001). The Bland and Altman's limit of agreement was -0.389 - 0.644 g/dl with the mean difference being 0.127 (95% CI: 0.102-0.153) and a non-significant difference in variability between the two measurements (p = 0.843). After adjusting to assess the effect of other possible confounders such as sex, age and category of person, there was no

  11. Contextualising and Visualising Saints in the 14-15th century

    Horníčková, Kateřina

    -, č. 62 (2011), s. 21-39 ISSN 1029-0737 Institutional research plan: CEZ:AV0Z90090514 Keywords : medieval art * saints' representation * representation of place Subject RIV: AA - Philosophy ; Religion

  12. [Department of Otorhinolaryngology of the I.P. Pavlov Saint-Peterburg First State Medical University].

    Karpishchenko, S A

    This article is designed to report the results of the analysis ofacademic, scientific, and clinical activities of the Department of Otorhinolaryngology of the I.P. Pavlov Saint-Peterburg First State Medical University.

  13. The Reaction of Oxy Hemoglobin with Nitrite

    Hathazi, Denisa; Scurtu, Florina; Bischin, Cristina

    2018-01-01

    The autocatalytic reaction between nitrite and the oxy form of globins involves free radicals. For myoglobin (Mb), an initial binding of nitrite to the iron-coordinated oxygen molecule was proposed; the resulting ferrous-peroxynitrate species was not detected, but its decay product, the high...... to a simple kinetic model involving a transient met-aqua form, in contrast to the ferryl detected in the case of Mb in a similar reaction sequence. These data are in line with a previous observation of a transient accumulation of ferryl Hb under auto-catalytic conditions at much lower concentrations......-peroxynitrate. Density functional theory (DFT) calculations support this latter assignment. The reaction allows for differentiating between the reactivities of various chemically modified hemoglobins, including candidates for blood substitutes. Polymerization of hemoglobin slows the nitrite-induced oxidation, in sharp...

  14. Hemoglobin promotes somatic embryogenesis in peanut cultures.

    Jayabalan, N; Anthony, P; Davey, M R; Power, J B; Lowe, K C

    2004-02-01

    Critical parameters influencing somatic embryogenesis include growth regulators and oxygen supply. Consequently, the present investigation has focused on optimization of a somatic embryogenic system for peanut (Arachis hypogaea L.) through media supplementation with the auxin, picloram. The latter at 30 mg L(-1) was optimal for inducing regeneration of somatic embryos from cultured explants of zygotic embryos. In contrast, somatic embryogenesis did not occur in the absence of this growth regulator. An assessment has also been made of the beneficial effect on somatic embryogenesis and plant regeneration of the commercial hemoglobin (Hb) solution, Erythrogen. Hemoglobin at 1:50 and 1:100 (v:v) stimulated increases in mean fresh weight (up to a maximum of 57% over control), mean number of explants producing somatic embryos (15%) and mean number of somatic embryos per explant (29%).

  15. MARKETING STRATEGY FOR THE FINNISH TOURIST COMPANY BASED ON SAINT PETERSBURG MARKET RESEARCH

    Miroshnichenko, Julia

    2014-01-01

    The goal of this thesis is to get a marketing strategy for proposed tourist business through the field-work marketing research. The purpose of this marketing research was to investigate the attitudes of Russian tourists in Saint Pe-tersburg towards Finland as a destination. The research examines the respondents’ own evaluation of the Finnish tourism possibilities, as well as the expert evaluation (made by the professionals of tourist agencies in Saint Petersburg) of the Finnish tourist ma...

  16. Facile Interfacial Electron Transfer of Hemoglobin

    Chunhai Fan

    2005-12-01

    Full Text Available Abstract: We herein describe a method of depositing hemoglobin (Hb and sulfonated polyaniline (SPAN on GC electrodes that facilitate interfacial protein electron transfer. Well-defined, reproducible, chemically reversible peaks of Hb and SPAN can be obtained in our experiments. We also observed enhanced peroxidase activity of Hb in SPAN films. These results clearly showed that SPAN worked as molecular wires and effectively exchanged electrons between Hb and electrodes.Mediated by Conjugated Polymers

  17. Radio-ligand immunoassay for human hemoglobin variants

    Javid, J.; Pettis, P.K.; Miller, J.E.

    1981-01-01

    A quantitative method is described for the individual assay of human hemoglobin variants occurring singly or in mixture. The hemoglobin to be assayed is bound to specific antibody; the immune complex is attached to protein A-containing S. aureus and removed from the mixture. The hemoglobin thus isolated is quantified by its ability to bind radiolabeled haptoglobin. The technique is accurate and distinguishes among the 4 hemoglobins tested, namely Hb A, S, C and F. It has the advantage over conventional radioimmunoassay that a single probe, radiolabeled haptoglobin, is needed for the specific assay of any hemoglobin. (Auth.)

  18. Induction of nano pore in Agrobacterial hemoglobin

    Mojtaba Tousheh

    2014-01-01

    Full Text Available Introduction: A variety of oxygen-transport and -binding proteins exist in organisms including bacteria, protozoans, and fungi all have hemoglobin-like proteins. In addition to dealing with transport and sensing of oxygen, they may also deal with NO2, CO2, sulfide compounds, and even O2 scavenging in environments. Also they detoxified chlorinated materials like P450 enzymes and peroxidases and use as a detector of nitrate and hydrogen peroxide. Pore-forming bacterial globins are interested for filtration. Materials and methods: Although there are data for bacterial toxin as a filter, here we used Agrobacterial hem to induce nano pore in the heme structure using point mutation. Results: Investigations showed that three amino acids leucine 76, alanine 83 and histidine 80 are important for pore formation in Agrobacterium hemoglobin. A point mutation on leucine 76 to glycine, histidine 80 to asparagine and alanine 83 to lysine step by step led to create the nano pore 0.7- 0.8 nm in the globin. Discussion and conclusion: These mutations in bacterial hemoglobin increase the stability when mutation is with it’s at pH7. This mutation decreases the aliphatic index however increase the stability index.

  19. Imidazolidinone adducts of peptides and hemoglobin

    San George, R.C.; Hoberman, H.D.

    1986-01-01

    Acetaldehyde reacts selectively with the terminal amino groups of the α and β chains of hemoglobin to form stable adducts, the structures of which, based on 13 C NMR studies, are proposed to be diastereomeric 2-methyl imidazolidin-4-ones. In this scheme, acetaldelhyde forms a reversible Schiff base with the α-amino groups of the polypeptide chains which cyclize with the amide nitrogen of the first peptide bond to form the stable imidazolidinone adducts. In support of this mechanism, the authors found that in following the reaction of the peptide val-gly-gly with [1,2- 13 C] acetaldehyde, 13 C NMR resonances attributed to a Schiff base (δ = 170 ppm) were observed which slowly disappeared prior to appearance of resonances from a pair of stable adducts (δ = 70 and 71 ppm) believed to be the diastereomeric imidazolidinones. Schiff base formation appeared to limit the overall rate. Tetraglycine reacted in a similar manner but with a resonance from a single stable adduct observed representing the enantiomeric imidazolidinone adducts of this peptide. Peptides with proline in position 2 should be incapable of forming imidazolidinones, and the authors found that ala-pro-gly did in fact fail to form a stable adduct with acetaldehyde. The 2-methyl imidazolidin-4-one adducts of hemoglobin may be useful in determining the contribution of the amino terminal groups to the structure and functional properties of hemoglobins

  20. Small angle X-ray scattering on concentrated hemoglobin solutions

    Zinke, M.; Damaschun, G.; Mueller, J.J.; Ruckpaul, K.

    1978-01-01

    The small-angle X-ray scattering technique was used to determine the intermolecular structure and interaction potentials in oxi-and deoxi-hemoglobin solutions. The pair correlation function obtained by the ZERNICKE-PRINS equation characterizes the intermolecular structure of the hemoglobin molecules. The intermolecular structure is concentration dependent. The hemoglobin molecules have a 'short range order structure' with a range of about 4 molecule diameters at 324 g/l. The potential functions of the hemoglobin-hemoglobin interaction have been determined on the basis of fluid theories. Except for the deoxi-hemoglobin solution having the concentration 370 g/l, the pair interaction consists in a short repulsion and a weak short-range attraction against kT. The potential minimum is between 1.2 - 1.5 nm above the greatest hemoglobin diameter. (author)

  1. Hemoglobin estimation by the HemoCue® portable hemoglobin photometer in a resource poor setting

    Idriss Ali

    2011-04-01

    Full Text Available Abstract Background In resource poor settings where automated hematology analyzers are not available, the Cyanmethemoglobin method is often used. This method though cheaper, takes more time. In blood donations, the semi-quantitative gravimetric copper sulfate method which is very easy and inexpensive may be used but does not provide an acceptable degree of accuracy. The HemoCue® hemoglobin photometer has been used for these purposes. This study was conducted to generate data to support or refute its use as a point-of-care device for hemoglobin estimation in mobile blood donations and critical care areas in health facilities. Method EDTA blood was collected from study participants drawn from five groups: pre-school children, school children, pregnant women, non-pregnant women and men. Blood collected was immediately processed to estimate the hemoglobin concentration using three different methods (HemoCue®, Sysmex KX21N and Cyanmethemoglobin. Agreement between the test methods was assessed by the method of Bland and Altman. The Intraclass correlation coefficient (ICC was used to determine the within subject variability of measured hemoglobin. Results Of 398 subjects, 42% were males with the overall mean age being 19.4 years. The overall mean hemoglobin as estimated by each method was 10.4 g/dl for HemoCue, 10.3 g/dl for Sysmex KX21N and 10.3 g/dl for Cyanmethemoglobin. Pairwise analysis revealed that the hemoglobin determined by the HemoCue method was higher than that measured by the KX21N and Cyanmethemoglobin. Comparing the hemoglobin determined by the HemoCue to Cyanmethemoglobin, the concordance correlation coefficient was 0.995 (95% CI: 0.994-0.996, p Conclusion Hemoglobin determined by the HemoCue method is comparable to that determined by the other methods. The HemoCue photometer is therefore recommended for use as on-the-spot device for determining hemoglobin in resource poor setting.

  2. Utilidad de la Ortopantografía vs TAC facial en el diagnóstico de fracturas de mandíbula

    M. P. Casteleiro Roca

    Full Text Available Nuestro objetivo es conocer la utilidad de la Ortopantografía frente a la TAC (Tomografía Axial Computarizada para el diagnóstico de las fracturas de mandíbula, pretendiendo implantar en nuestro hospital recomendaciones basadas en la evidencia. Llevamos a cabo una revisión sistemática en PubMed: la estrategia de búsqueda se define como "Jaw Fractures" [MeSH] AND "Tomography, X-Ray Computed" [MeSH], restringiendo dicha búsqueda a los últimos 5 años (2001-2005 y limitándola a inglés y español. Los criterios de inclusión establecidos son: diseños de estudio, revisiones sistemáticas, meta-análisis, estudios comparando utilidad de Ortopantografía frente a TAC en diagnóstico de fracturas mandibulares. Como criterios de exclusión marcamos: casos clínicos, cartas al director, no comparar Ortopantografía frente a TAC en diagnóstico de fracturas mandibulares. Obtenemos 41 artículos que analizamos y clasificamos aplicando los criterios descritos y obteniendo finalmente 3 artículos. Actualmente, como prueba única, la TAC proporciona más información diagnóstica que la Ortopantografía en las fracturas de mandíbula.

  3. Saint Agatha Religious Festival in Catania: Stakeholders’ Functions and Relations

    Salvatore Cannizzaro

    2017-03-01

    Full Text Available The purpose of the paper is to develop an explorative analysis of the functions and relations among actors involved in the organization and implementation of the Saint Agatha Religious Festival in Catania attracting nearly one million presences during the first week of February. The research is based on the survey of different sources of information, such as literature, news, media, and deep interviews with key informants pertaining to civil and religious institutions. The survey is designed to profile the Festival in terms of history, the character of the stakeholders, size, origin of assets, venues used, decision-making structure, and programs. The Festival’s use of volunteers and sponsors is specifically addressed. Empirical research sketches the network of stakeholders, the relationship between organizations, the importance of local social actors and strategies in enhancing local culture and sustainable tourism, regarding, in particular, the socio-cultural impacts of religious tourism. The local society has historical peculiarities which impose prudential considerations in generalizing about findings, and a comparative study with other Sicilian and/or Italian religious festivals will be important, mainly in order to delineate the actual sustainability of Festivals. The framework developed in this study can be helpful in the application of local social policies and also help comparative festival studies.

  4. SAINT APOLLONIA: BETWEEN PAGANISM AND CHRISTIANITY IN MEDICINE

    Gheorghe Gh. BĂLAN

    2015-03-01

    Full Text Available The history of medicine and dentistry shows that dental medicine is entitled to take upon itself, as representative elements of the field, symbols or spiritual protectors, religious (either Christian or pagan archetypes from different historical periods. These paved the way for the elaboration of a long-lasting set of professional and ethical criteria that ennoble today the dental profession. The present study analyzes some of the symbols of historical-religious nature, stressing their cultural impact and the manner in which such symbols are interpreted in various scientific, medical, theological, artistic contexts and, last but not least, in the general social perception. The professional ethical domain of dentistry makes use of numerous symbols with religious connotation, the more so that this branch of medicine and the various religions have numerous elements in common. Either stylistically, or appearing as products of folk culture, the main symbolistic or legendary references specific to dental culture are the legend of Cadmus and the canonization of Saint Apollonia, the champion of dentists and of those suffering from toothache. Such symbols give to the representatives of this profession a feeling of belonging to a noble medical domain; they also decode and facilitate communication with patients, therefore being outflanked by the idea that awareness on the existence of such religious symbols and on their practical cohesion is especially helpful.

  5. Supercar Experience | 6 September | Saint-Julien-en-Genevois

    2015-01-01

    On Sunday, 6 September, don’t miss the fourth Supercars Experience day (see here) organised by members of CERN and the Les Amis Porschistes du Léman association.   Supercars at the 2014 experience day. Photo: Kevin Mazzilli. From 9.30 a.m. to 6 p.m., in the Vitam leisure centre car park (Saint-Julien-en-Genevois), the owners of around 50 supercars (Porsche, Ferrari, Lamborghini, Lotus, Venturi, and more) will be offering passengers rides lasting 10 to 15 minutes. For 10 euros, you can go for a spin in a sports car; for 50 euros, you can choose one of the most prestigious models. All of the money collected will go to the Kumansansa association, which helps disadvantaged children in Zambia. “Since the first edition in 2012, the event has been a real success with the public, and the money collected each year allows us to put into action our initiatives with children in Zambia,” says François Butin, co-organiser with ...

  6. The harmonious relationship between faith and science from the perspective of some great saints: A brief comment.

    Cortés, Manuel E; Del Río, Juan Pablo; Vigil, Pilar

    2015-02-01

    The objective of this editorial is to show that a harmonious relationship between science and faith is possible, as exemplified by great saints of the Catholic Church. It begins with the definitions of science and faith, followed by an explanation of the apparent conflict between them. A few saints that constitute an example that a fruitful relationship between these two seemingly opposed realities has been possible are Saint Albert the Great, Saint John of the Cross, Saint Giuseppe Moscati, and Saint Edith Stein, among others, and this editorial highlights their deep contributions to the dialogue between faith and reason. This editorial ends with a brief discussion on whether it is possible to be both a scientist and a man of faith.

  7. Diet of the oilfish Ruvettus pretiosus (Perciformes: Gempylidae in the Saint Peter and Saint Paul archipelago, Brazil

    Danielle de Lima Viana

    2012-06-01

    Full Text Available Feeding aspects of the oilfish, Ruvettus pretiosus, were studied based on 360 stomachs of both male and female specimens caught off the Saint Peter and Saint Paul Archipelago. The total length of the specimens ranged from 52.4 cm to 189.0 cm. Of the 360 stomachs examined, 135 presented some food and 225 were empty. Thirty-four taxa were identified, represented by 16 fish, 17 cephalopods and 1 crustacean. The stabilization of the food items richness was attained at 35 food items and 104 stomachs, approximately. A remarkable predation upon the flying fish Cheilopogon cyanopterus was observed around SPSPA, directly related to the main reproductive period of this species in the area. The oilfish's food spectrum shows that the species feeds on a wide vertical range in the water column, catching prey items at the surface or in shallow waters, as well as epi-mesopelagic fish, in addition to mesopelagic cephalopods.Aspectos alimentares do peixe-prego, Ruvettus pretiosus, foram estudados com base nos estômagos de 360 espécimes, de ambos os sexos, capturados nos arredores do Arquipélago de São Pedro e São Paulo. Todos os exemplares foram capturados com linha de mão. O comprimento total dos exemplares variou de 52,4 cm a 189,0 cm. Dos 360 estômagos examinados, 135 apresentaram algum alimento e 225 estavam vazios. Trinta e quatro táxons foram identificados, representados por 16 peixes, 17 cefalópodes e um crustáceo. A estabilização da riqueza dos itens alimentares foi obtida com 35 itens e 104 estômagos. Uma predação notável sobre o peixe-voador Cheilopogon cyanopterus foi observada nas adjacências do ASPSP, diretamente relacionada com o principal período reprodutivo dessa espécie na área. O espectro alimentar do peixe-prego mostra que a espécie se alimenta em uma ampla faixa vertical na coluna d'agua, capturando desde presas de superfície ou águas rasas, a peixes epi-mesopelágicos, além de cefalópodes mesopelágicos.

  8. Hemichrome formation during hemoglobin Zurich denaturation

    Zago, M.A.; Costa, F.F.; Botura, C.; Baffa, O.

    1988-01-01

    Electron paramagnetic resonance (EPR)spectrum of hemoglobin Zurich, after oxidation, storage and heating, showed several absorption derives in the high field region (g ≅ 2) which are indicative of hemichrome formation. Characteristic visible spectra of hemichromes were observed for oxidized Hb Zurich and for its spontaneous precipitate. The proportional increase of EPR signals at g ≅ 2 and decrease at g = 6.37, the constant ratio of absorbance at 540 nm to 280 nm during heating, and the similarity of this ratio for spontaneously precipitated HbA and for Hb Zurich indicate that heme is not lost during the first steps of Hb Zurich denaturation. (author) [pt

  9. Relationship of Baseline Hemoglobin Level with Serum Ferritin, Postphlebotomy Hemoglobin Changes, and Phlebotomy Requirements among HFE C282Y Homozygotes

    Seyed Ali Mousavi

    2015-01-01

    Full Text Available Objectives. We aimed to examine whether baseline hemoglobin levels in C282Y-homozygous patients are related to the degree of serum ferritin (SF elevation and whether patients with different baseline hemoglobin have different phlebotomy requirements. Methods. A total of 196 patients (124 males and 72 females who had undergone therapeutic phlebotomy and had SF and both pre- and posttreatment hemoglobin values were included in the study. Results. Bivariate correlation analysis suggested that baseline SF explains approximately 6 to 7% of the variation in baseline hemoglobin. The results also showed that males who had higher (≥150 g/L baseline hemoglobin levels had a significantly greater reduction in their posttreatment hemoglobin despite requiring fewer phlebotomies to achieve iron depletion than those who had lower (<150 g/L baseline hemoglobin, regardless of whether baseline SF was below or above 1000 µg/L. There were no significant differences between hemoglobin subgroups regarding baseline and treatment characteristics, except for transferrin saturation between male subgroups with SF above 1000 µg/L. Similar differences were observed when females with higher (≥138 g/L baseline hemoglobin were compared with those with lower (<138 g/L baseline hemoglobin. Conclusion. Dividing C282Y-homozygous patients into just two subgroups according to the degree of baseline SF elevation may obscure important subgroup variations.

  10. Interaction of thyroid hormone and hemoglobin: nature of the interaction and effect of hemoglobin on thyroid hormone radioimmunoassay

    Davis, P.J.; Yoshida, K.; Schoenl, M.

    1980-01-01

    Gel filtration of human erythrocyte (RBC) lysate incubated with labeled thyroxine (Tu) or triiodothyronine (Tt) revealed co-elution of a major iodothyronine-binding fraction (R-2) and hemoglobin. Solutions of purified human hemoglobin and Tt also showed co-elution of hormone and hemoglobin. Because hematin and protoporphyrin were shown to bind labeled Tt, the oxygen-binding site on hemoglobin was excluded as the site of iodothyronine-hemoglobin interaction. Analysis of hormone binding by heme and globin moieties showed Tt binding to be limited to the heme fraction. Addition of excess unlabeled Tt to hemoglobin or heme incubated with labeled Tt indicated 75% to 90% of hormone binding was poorly dissociable. These observations suggested that the presence of hemoglobin in RBC lysate or in serum could influence the measurement of Tu and Tt by specific radioimmunoassay (RIA). Subsequent studies of the addition to serum of human hemoglobin revealed a significant reduction in Tt and Tu detectable by RIA in the presence of this protein. The effect was influenced by the concentration of hemoglobin and by duration and temperature of incubations of hemoglobin and serum prior to RIA

  11. Relationship of Baseline Hemoglobin Level with Serum Ferritin, Postphlebotomy Hemoglobin Changes, and Phlebotomy Requirements among HFE C282Y Homozygotes

    Mousavi, Seyed Ali; Mahmood, Faiza; Aandahl, Astrid; Knutsen, Teresa Risopatron; Llohn, Abid Hussain

    2015-01-01

    Objectives. We aimed to examine whether baseline hemoglobin levels in C282Y-homozygous patients are related to the degree of serum ferritin (SF) elevation and whether patients with different baseline hemoglobin have different phlebotomy requirements. Methods. A total of 196 patients (124 males and 72 females) who had undergone therapeutic phlebotomy and had SF and both pre- and posttreatment hemoglobin values were included in the study. Results. Bivariate correlation analysis suggested that baseline SF explains approximately 6 to 7% of the variation in baseline hemoglobin. The results also showed that males who had higher (≥150 g/L) baseline hemoglobin levels had a significantly greater reduction in their posttreatment hemoglobin despite requiring fewer phlebotomies to achieve iron depletion than those who had lower (baseline hemoglobin, regardless of whether baseline SF was below or above 1000 µg/L. There were no significant differences between hemoglobin subgroups regarding baseline and treatment characteristics, except for transferrin saturation between male subgroups with SF above 1000 µg/L. Similar differences were observed when females with higher (≥138 g/L) baseline hemoglobin were compared with those with lower (baseline hemoglobin. Conclusion. Dividing C282Y-homozygous patients into just two subgroups according to the degree of baseline SF elevation may obscure important subgroup variations. PMID:26380265

  12. Porphyromonas endodontalis binds, reduces and grows on human hemoglobin.

    Zerr, M; Drake, D; Johnson, W; Cox, C D

    2001-08-01

    Porphyromonas endodontalis is a black-pigmented, obligate anaerobic rod-shaped bacterium implicated as playing a major role in endodontic infections. We have previously shown that P. endodontalis requires the porphyrin nucleus, preferably supplied as hemoglobin, as a growth supplement. The bacteria also actively transport free iron, although this activity does not support growth in the absence of a porphyrin source. The purpose of this study was to further investigate the binding and subsequent utilization of human hemoglobin by P. endodontalis. P. endodontalis binds hemoglobin and reduces the Fe(III) porphyrin, resulting in a steady accumulation of ferrous hemoglobin. Reduction of methemoglobin was similar to the extracellular reduction of nitrobluetetrazolium in the presence of oxidizable substrate. Turbidimetric and viable cell determinations showed that P. endodontalis grew when supplied only hemoglobin. Therefore, we conclude that hemoglobin appears to serve as a sole carbon and nitrogen source, and that these bacteria reduce extracellular compounds at the expense of oxidized substrates.

  13. Characterization of hemoglobin-benzo[a]pyrene adducts

    Haugen, D.A.; Myers, S.R.

    1987-01-01

    Cultures of Syrian hamster embryo (SHE) cells were supplemented with human Hb (0.2 mM heme) and [ 3 H]BP (1 μM). After a 24-h incubation, the medium was removed and subjected to cation-exchange liquid chromatography (CM-Sepharose) to resolve hemoglobins from serum proteins in the medium. The BP-treated Hb was subjected to analysis in each of three column chromatographic systems established for isolation and characterization of human hemoglobin and its genetic and post-translationally modified variants. Results demonstrate that hemoglobin-carcinogen adducts can be resolved from native hemoglobin by established conventional and high-performance liquid chromatographic procedures, suggesting the basis for development of general approaches for isolating and characterizing hemoglobin-carcinogen adducts. The results also suggest the basis for a model system in which adducts between carcinogens and human hemoglobin are formed in cultures of mammalian cells or tissues

  14. Studies on radiation induced changes in bovine hemoglobin type A

    Wdzieczak, J.; Duda, W.; Leyko, W.

    1978-01-01

    In this paper the structural and functional changes of gamma irradiated bovine hemoglobin are presented. Aqueous solutions/1%/of HbO 2 were irradiated in air with doses ranging from 1 to 4 Mrad. Isoelectric focusing indicated change of the charge of irradiated hemoglobin. The isoelectric point of hemoglobin was displaced towards more acid values with increasing doses, up from 1 Mrad. Fingerprint analysis and peptide column chromatography of irradiated hemoglobin demonstrated disturbances increasing with the dose. These changes were confirmed by amino acid analysis which showed that Cys, Met, Trp, His, Pro and Tyr residues were destroyed or modified following irradiation. At doses exceeding 1 Mrad the irradiated solutions of hemoglobin showed a decrease of heme-heme interaction and an increase of affinity for oxygen. Differences observed in oxygen-dissociation curves seem to be correlated with the radiation induced destruction of amino acid residues which are responsible for the functional properties of hemoglobin. (auth.)

  15. A review of variant hemoglobins interfering with hemoglobin A1c measurement.

    Little, Randie R; Roberts, William L

    2009-05-01

    Hemoglobin A1c (HbA1c) is used routinely to monitor long-term glycemic control in people with diabetes mellitus, as HbA1c is related directly to risks for diabetic complications. The accuracy of HbA1c methods can be affected adversely by the presence of hemoglobin (Hb) variants or elevated levels of fetal hemoglobin (HbF). The effect of each variant or elevated HbF must be examined with each specific method. The most common Hb variants worldwide are HbS, HbE, HbC, and HbD. All of these Hb variants have single amino acid substitutions in the Hb beta chain. HbF is the major hemoglobin during intrauterine life; by the end of the first year, HbF falls to values close to adult levels of approximately 1%. However, elevated HbF levels can occur in certain pathologic conditions or with hereditary persistence of fetal hemoglobin. In a series of publications over the past several years, the effects of these four most common Hb variants and elevated HbF have been described. There are clinically significant interferences with some methods for each of these variants. A summary is given showing which methods are affected by the presence of the heterozygous variants S, E, C, and D and elevated HbF. Methods are divided by type (immunoassay, ion-exchange high-performance liquid chromatography, boronate affinity, other) with an indication of whether the result is artificially increased or decreased by the presence of a Hb variant. Laboratorians should be aware of the limitations of their method with respect to these interferences. 2009 Diabetes Technology Society.

  16. Conseqüências no crescimento de maxila e mandíbula de defeito ósseo cirúrgico no ramo da mandíbula de ratos Consequences on the growth of maxilla and mandible of surgical bone defect on mandibular ramus of rats

    Lucimar Rodrigues

    2004-10-01

    Full Text Available OBJETIVO: Analisar as conseqüências no crescimento de maxila e mandíbula de defeito ósseo cirúrgico simulando fratura no ramo da mandíbula. MÉTODOS: Foram utilizados 25 ratos Wistar com um mês de idade. Sob anestesia geral e por meio de incisão submandibular. Foi realizada osteotomia vertical no ramo da mandíbula do lado direito com emprego de motor cirúrgico. Após período de dois meses os animais foram sacrificados, os tecidos moles retirados e as hemimandíbulas desarticuladas. Foram realizadas incidências radiográficas axiais para o crânio e laterais para as hemimandíbulas. A seguir, por intermédio de um sistema de computador foram obtidas medidas lineares da maxila e das hemimandíbulas. Foi empregado o teste "t" de Student para verificação da significância da diferença entre os lados experimental e controle. RESULTADOS: A diferença foi significante para a altura do ramo (p=0,010 e comprimento da mandíbula referente ao côndilo (p=0,015 e ao ângulo (pPURPOSE: To analyse the consequences on the growth of maxilla and mandible of a surgical bone defect that simulates a mandibular ramus fracture. METHODS: A group of 25 one-month-old Wistar rats were used in this study. Under general anesthesia, and through a submandibular incision, a vertical osteotomy on the right side of the mandibular ramus was made using a surgical drill. The animals were sacrificed after two months, soft tissues removed, and the mandible disarticulated. The skull was submitted to axial radiograph and the hemimandibles to a lateral radiograph. With these, cephalometric mensurations were made through a computer system, and the obtained values submitted to Student's t-test. RESULTS: The height of the mandibular ramus presented significant difference (p=0,010 as well as the length of mandible, both to the condyle (P=0,015 and the angle (p=0,001. There was no significant difference to the mensurations of the maxilla. CONCLUSION: The consequences of the

  17. The Forging of a White Gay Aesthetic at the Saint, 1980–84

    Tim Lawrence

    2011-06-01

    Full Text Available Based on original interviews with key protagonists and documentary research, the article examines the way in which the DJs who worked at the Saint forged a white gay aesthetic across the first half of the 1980s. A private party located in the East Village, New York, the Saint attracted a privileged white male crowd, and this group's position within the emerging culture of neoliberalism, along with the deepening impact of the AIDS epidemic, encouraged its spinners to sever their ties with sounds that were associated with blackness. However, if Saint DJs rejected a high proportion of records that were being released by New York's independents, and also snubbed Chicago house when it broke in 1985, their forging of an aesthetic that emphasised seamless transitions, often between records that contained similar sonic qualities, preempted the style of mixing that would be popularised in house music culture.

  18. Síntese e caracterização de compostos diorganoestânicos com ácido dl-mandélico

    TERRA, Vilma Reis; BARBIÉRI, Roberto Santos; CASTELO BRANCO, Pedro de Azevedo; ABRAS, Anuar

    1998-01-01

    Por reação de quantidades eqüimoleculares de R2SnO ou R2SnCl2 (R = -CH3; -C4H9) com ácido dl-mandélico, C6H5CH(OH)COOH, em meio de etanol, foram obtidos novos compostos formulados como [(LR2Sn)2O] [L= C6H5CH(OH)COO-], nos quais o átomo de estanho é pentacoordenado, com o ligante L estabelecendo uma ligação bidentada através dos átomos de oxigênio dos grupos ácido e hidroxila alcoólica. Nas mesmas condições, nenhum produto obtido a partir da reação de (C6H5)2SnO ou (C6H5)2SnCl2 pode ser identi...

  19. A New Pilgrimage in Portugal: Following the Steps of Saint Nuno

    Carla Braga

    2013-12-01

    Full Text Available Tourism is an ever-changing reality. Pilgrimages need different stimuli to attract new followers. In this context we propose to create an itinerary following the steps of Saint Nuno of Santa Maria, canonized in 2009. Nuno Álvares Pereira was the real name of Saint Nuno, who was granted the title Constable of Portugal, and became a historic legend in the independence wars of Portugal during the political crisis of 1383-1385. After fighting against the power of Castile (Spain he decided to devote his life to religion as a Carmelite Friar. He represents the perfect hero of the Middle Ages - associating military prowess with a religious character. Our proposal is to create a religious itinerary based on facts of Saint Nuno’s life, so that any visitor may easily discover the country following the steps of this saint who was deeply devoted to the Virgin - in fact, all temples he founded and restored were dedicated to Our Lady. One of his most famous foundations is the Carmelite Convent in Lisbon, which long after his death was an outstanding popular pilgrimage place, and today is still a strong visitor attraction. This exploratory study is based on literature review and text analyses about religious tourism, itinerary design and the life of the saint. The fieldwork includes acknowledging the different sites related to the saint. We believe that it is possible to create an original religious itinerary in Portugal, which will attract not only foreigners but also domestic visitors, increasing the ‘Production and Consumption of the Pilgrimage Tourism Experience’.

  20. On the Hierarchy of Saints on Altars. Visitation Records of Otto Friedrich Buchheim, the Bishop of Ljubljana (1641–1664

    Lavrič, Ana

    2011-09-01

    Full Text Available The visitation records of Otto Friedrich Buchheim, the Bishop of Ljubljana from 1641–1664, offer an insight into the rules governing the disposition of saintly figures in altar retables. The central place was accorded to the titular saint, while companion saints are positioned in pairs (separately for each level of the retable in such a way that those of higher rank are placed on the more distinguished gospel side, whereas those of lower rank stand on the subordinate epistle side. The priority of one saint over another was not a matter of a random choice, but of a fixed hierarchical order which was created over the course of centuries in the Litany of All Saints and also in the hymns of the officium for All Saints Day; this hierarchy, as Buchheim remarks, is "in agreement with the general feeling of the Catholic Church". Ecclesiastical art in Slovenia shows that in the Gothic period the hierarchical principle governing the disposition of saintly figures was not yet firmly fixed, but it was fully established in the late Renaissance and Baroque periods, which coincides with the period of unification of the Litany of All Saints for the entire Catholic Church. Later it started to loosen again, yet it remained in force up to the 20th century.

  1. THE IMPACT OF SAINT PARASCHEVA PILGRIMAGE ON TOURISM IN IASI COUNTY

    Alexandra Georgiana PARASCA

    2015-07-01

    Full Text Available Nowadays, pilgrimage is a part of international tourism, being considered religious tourism, because it contributes to the development of economy, like any other type of tourism. This research paper takes into consideration the pilgrimage to Saint Paracheva, and how it helps the development of religious tourism in Iasi county, the economical implications. We try to capture the importance of Saint Parascheva pilgrimage, because year after year it bring many more pilgrims to Iasi city. In time, it could become an important place of pilgrimage at European level.

  2. The Segmented Aperture Interferometric Nulling Testbed (SAINT) I: overview and air-side system description

    Hicks, Brian A.; Lyon, Richard G.; Petrone, Peter; Ballard, Marlin; Bolcar, Matthew R.; Bolognese, Jeff; Clampin, Mark; Dogoda, Peter; Dworzanski, Daniel; Helmbrecht, Michael A.; Koca, Corina; Shiri, Ron

    2016-07-01

    This work presents an overview of the Segmented Aperture Interferometric Nulling Testbed (SAINT), a project that will pair an actively-controlled macro-scale segmented mirror with the Visible Nulling Coronagraph (VNC). SAINT will incorporate the VNC's demonstrated wavefront sensing and control system to refine and quantify end-to-end high-contrast starlight suppression performance. This pathfinder testbed will be used as a tool to study and refine approaches to mitigating instabilities and complex diffraction expected from future large segmented aperture telescopes.

  3. Ecole d’été de probabilités de Saint-Flour XXVIII

    2000-01-01

    This volume contains lectures given at the Saint-Flour Summer School of Probability Theory during 17th Aug. - 3rd Sept. 1998. The contents of the three courses are the following: - Continuous martingales on differential manifolds. - Topics in non-parametric statistics. - Free probability theory. The reader is expected to have a graduate level in probability theory and statistics. This book is of interest to PhD students in probability and statistics or operators theory as well as for researchers in all these fields. The series of lecture notes from the Saint-Flour Probability Summer School can be considered as an encyclopedia of probability theory and related fields.

  4. Oxygen binding to nitric oxide marked hemoglobin

    Louro, S.R.W.; Ribeiro, P.C.; Bemski, G.

    1979-04-01

    Electron spin resonance spectra of organic phosphate free human hemoglobin marked with nitric oxide at the sixth coordination position of one of the four hemes allow to observe the transition from the tense (T) to the relaxed (R) conformation, as a function of parcial oxygen pressure. The spectra are composites of contributions from α sub(T), α sub(R) and β chains spectra, showing the presence of only two conformations: T and R. In the absence of organic phosphates NO binds to α and β chains with the same probability, but in the presence of phosphates NO combines preferentially with α chains. The dissociation of NO proceeds at least an order of magnitude faster in T than in R configuration. (author) [pt

  5. A thermodynamical measure of cooperativity: application to hemoglobin

    Jacchieri, S.G.; Ferreira, R.C.

    1984-01-01

    A comparative analysis of the heat requirements for dioxygen exchange is made for hemoglobin and myoglobin, the latter taken as the prototype of the vertebrate hemoglobin's ancestor. it is shown that cooperativity manifests itself also in terms of energy utilization. (Author) [pt

  6. Study of methyl bromide reactivity with human and mouse hemoglobin

    A study has been carried out on in-vitro reactivity of human and mouse hemoglobin spectrophotometrically at physiological pH, using different protein to reagent ratios. Hemoglobin side chains were modified with different concentrations of methyl bromide on agro-soil fumigant. To ascertain if the site of alkylation was the ...

  7. Biphasic oxidation of oxy-hemoglobin in bloodstains

    Bremmer, Rolf H.; de Bruin, Daniel M.; de Joode, Maarten; Buma, Wybren Jan; van Leeuwen, Ton G.; Aalders, Maurice C. G.

    2011-01-01

    In forensic science, age determination of bloodstains can be crucial in reconstructing crimes. Upon exiting the body, bloodstains transit from bright red to dark brown, which is attributed to oxidation of oxy-hemoglobin (HbO(2)) to met-hemoglobin (met-Hb) and hemichrome (HC). The fractions of

  8. Haptoglobin radioassay based on binding to solid-phase hemoglobin

    Hooper, D.C.; Reed, R.A.; Peacock, A.C.

    1979-01-01

    A specific and sensitive assay for haptoglobin based on binding to an easily prepred Sepharose-bound hemoglobin reagent is described. The assay is suitable for directly determining radiolabeled amino acid incorporation into haptoglobin in several liver cell systems in vitro and can be adapted to measure unlabeled free haptoglobin in plasma samples regardlss of the presence of the haptoglobin--hemoglobin complex

  9. Biphasic Oxidation of Oxy-Hemoglobin in Bloodstains

    Bremmer, R.H.; de Bruin, D.M.; de Joode, M.; Buma, W.J.; van Leeuwen, T.G.; Aalders, M.C.G.

    2011-01-01

    Background In forensic science, age determination of bloodstains can be crucial in reconstructing crimes. Upon exiting the body, bloodstains transit from bright red to dark brown, which is attributed to oxidation of oxy-hemoglobin (HbO2) to met-hemoglobin (met-Hb) and hemichrome (HC). The fractions

  10. 21 CFR 864.7400 - Hemoglobin A2 assay.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Hemoglobin A2 assay. 864.7400 Section 864.7400 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages § 864.7400 Hemoglobin A2...

  11. 21 CFR 864.7455 - Fetal hemoglobin assay.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Fetal hemoglobin assay. 864.7455 Section 864.7455 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages § 864.7455 Fetal hemoglobin...

  12. 21 CFR 522.1125 - Hemoglobin glutamer-200 (bovine).

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Hemoglobin glutamer-200 (bovine). 522.1125 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.1125 Hemoglobin glutamer-200 (bovine). (a) Specifications. Each 125 milliliter bag contains 13...

  13. Conformational changes in hemoglobin triggered by changing the iron charge

    Croci, S.; Achterhold, K.; Ortalli, I.; Parak, F. G.

    2008-01-01

    In this work the hemoglobin conformational changes induced by changing the iron charge have been studied and compared with Myoglobin. Moessbauer spectroscopy was used to follow the change of the iron conformation. In order to compare the conformational relaxation of hemoglobin and myoglobin, and to study a possible influence of the quaternary structure, an intermediate metastable state of hemoglobin has been created by low temperature X-ray irradiation of methemoglobin. The irradiation reduces the Fe(III) of the heme groups to Fe(II) Low Spin, where the water is still bound on the sixth coordination. Heating cycles performed at temperatures from 140 K to 200 K allow the molecules to overcome an activation energy barrier and to relax into a stable conformation such as deoxy-hemoglobin or carboxy-hemoglobin, if CO is present. Slightly different structures (conformational substates) reveal themselves as a distribution of energy barriers (ΔG). The distribution of the activation energy, for the decay of the Fe(II) Low Spin intermediate, has been fitted with a Gaussian. For comparison, published myoglobin data were re-analysed in the same way. The average energy value at characteristic temperature is very similar in case of myoglobin and hemoglobin. The larger Gaussian energy distribution for myoglobin with respect to hemoglobin shows that more conformational substates are available. This may be caused by a larger area exposed to water. In hemoglobin, part of the surface of the chains is not water accessible due to the quaternary structure.

  14. Saint Joseph's University Institute for Environmental Stewardship

    McCann, Micahel P. [Saint Joseph' s Univ., Philadelphia, PA (United States); Springer, Clint J. [Saint Joseph' s Univ., Philadelphia, PA (United States)

    2014-06-03

    future climate scenarios is local adaptation and not necessarily genome size as has been hypothesized in the literature. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center at Saint Joseph's University. The roof system includes four test plots, each with a different drainage system, instrumentation to monitor storm water retention, roof deck temperature, heat flux into and out of the building, rain fall, wind speed and direction, relative humidity and heat emission from the roof system. The vegetative roof was planted with 26 species of plants, distributed throughout the roof area, to assess species/variety growth and coverage characteristics, both in terms of the different drain layer systems, and in terms of the different exposures along the north to south axis of the building. Analysis of the drain layer performance, in terms of storm water retention, shows that the aggregate (stone) drainage layer system performed the best, with the moisture management mat system second, and the geotextile drain layer and reservoir sheet layer systems coming in last. This information is of value in the planning and design of vegetative roof systems since the different types of drainage layer systems have different installation costs and different weights. The different drainage layer systems also seem to be having an impact on plant growth and spread with the test plot with the reservoir sheet layer actually having the poorest plant coverage and plant spread of all areas of the roof studied. Plant growth performance analysis is ongoing, but significant differences have been observed in the third growing season ('13) along the north to south axis, with most species doing better towards the northern end of the roof (in

  15. Radiation - induced changes in the optical properties of hemoglobin molecule

    Selim, N.S; El-Marakby, S.M.

    2009-01-01

    Adult male albino rats were exposed to different doses of gamma radiation from Cs-137 source. Hemoglobin samples were analyzed 24 hrs after irradiation. The UV-visible spectrum of hemoglobin molecule was measured in the range 200 to 700 nm. The overall spectrum of the hemoglobin molecule showed hypochromicity that increased with dose increase. To investigate the effect of radiation on the hemoglobin molecule, different parameters of the spectrum were calculated: molar absorption coefficient, absorption cross section, transition dipole moment , dipole length, the optical energy gap and activation energy for each characteristic peak. The obtained results revealed that the radiation effect can induce rearrangement of the transition dipole moments and change molecular energy levels of the hemoglobin molecule

  16. INTRINSIC REGULATION OF HEMOGLOBIN EXPRESSION BY VARIABLE SUBUNIT INTERFACE STRENGTHS

    Manning, James M.; Popowicz, Anthony M.; Padovan, Julio C.; Chait, Brian T.; Manning, Lois R.

    2012-01-01

    SUMMARY The expression of the six types of human hemoglobin subunits over time is currently considered to be regulated mainly by transcription factors that bind to upstream control regions of the gene (the “extrinsic” component of regulation). Here we describe how subunit pairing and further assembly to tetramers in the liganded state is influenced by the affinity of subunits for one another (the “intrinsic” component of regulation). The adult hemoglobin dimers have the strongest subunit interfaces and the embryonic hemoglobins are the weakest with fetal hemoglobins of intermediate strength, corresponding to the temporal order of their expression. These variable subunit binding strengths and the attenuating effects of acetylation contribute to the differences with which these hemoglobin types form functional O2-binding tetramers consistent with gene switching. PMID:22129306

  17. Hemoglobin of mice with radiation-induced mutations at the hemoglobin loci

    Popp, R.A.; Stratton, L.P.; Hawley, D.K.; Effron, K.

    1979-01-01

    Chemical analyses were done on the abnormal hemoglobins of the five (101 x SEC)F 1 offspring of X- irradiated adult SEC mice to determine which hemoglobin genes were expressed in each hemoglobin variant. Three offspring of irradiated SEC males did not express either of the two kinds of α-chains normally found in all SEC mice. The deficient α-chain synthesis caused these mice to exhibit an α-thalassemia similar to human α-thalassemia. Scanning electron microscopy was used to show that many erythrocytes of mice with α-thalassemia have bizarre shapes; e.g. many erythrocytes appeared flattened or had thorny projections (acanthocytes). One mutant with a tandem duplication of a segment of chromosome 7 (site of locus determining β-chain structure) produced twice as much SEC as 101 β-chain polypeptides. One mutant that probably arose by non-disjunction of chromosome 7's in its unirradiated 101 mother and loss of chromosome 7 from the gamete of its irradiated SEC father did not express the SEC β-chain gene. (author)

  18. Hemoglobin of mice with radiation-induced mutations at the hemoglobin loci

    Popp, R A; Stratton, L P; Hawley, D K; Effron, K [Oak Ridge National Lab., TN (USA)

    1979-01-15

    Chemical analyses were done on the abnormal hemoglobins of the five (101 x SEC)F/sub 1/ offspring of X- irradiated adult SEC mice to determine which hemoglobin genes were expressed in each hemoglobin variant. Three offspring of irradiated SEC males did not express either of the two kinds of ..cap alpha..-chains normally found in all SEC mice. The deficient ..cap alpha..-chain synthesis caused these mice to exhibit an ..cap alpha..-thalassemia similar to human ..cap alpha..-thalassemia. Scanning electron microscopy was used to show that many erythrocytes of mice with ..cap alpha..-thalassemia have bizarre shapes; e.g. many erythrocytes appeared flattened or had thorny projections (acanthocytes). One mutant with a tandem duplication of a segment of chromosome 7 (site of locus determining ..beta..-chain structure) produced twice as much SEC as 101 ..beta..-chain polypeptides. One mutant that probably arose by non-disjunction of chromosome 7's in its unirradiated 101 mother and loss of chromosome 7 from the gamete of its irradiated SEC father did not express the SEC ..beta..-chain gene.

  19. Gravimetric structure for the abyssal mantle massif of Saint Peter and Saint Paul peridotite ridge, Equatorial Atlantic Ocean, and its relation to active uplift

    KENJI F. MOTOKI

    2014-06-01

    Full Text Available This paper presents gravimetric and morphologic analyses based on the satellite-derived data set of EGM2008 and TOPEX for the area of the oceanic mantle massif of the Saint Peter and Saint Paul peridotite ridge, Equatorial Atlantic Ocean. The free-air anomaly indicates that the present plate boundary is not situated along the longitudinal graben which cuts peridotite ridge, but about 20 km to the north of it. The high Bouguer anomaly of the peridotite ridge suggests that it is constituted mainly by unserpentinised ultramafic rocks. The absence of isostatic compensation and low-degree serpentinisation of the ultramafic rocks indicate that the peridotite ridge is sustained mainly by active tectonic uplift. The unparallel relation between the transform fault and the relative plate motion generates near north-south compression and the consequent tectonic uplift. In this sense, the peridotite massif is a pressure ridge due to the strike-slip displacement of the Saint Paul Transform Fault.

  20. Effect of Multiple Mutations in the Hemoglobin- and Hemoglobin-Haptoglobin-Binding Proteins, HgpA, HgpB, and HgpC, of Haemophilus influenzae Type b

    Morton, Daniel J.; Whitby, Paul W.; Jin, Hongfan; Ren, Zhen; Stull, Terrence L.

    1999-01-01

    Haemophilus influenzae requires heme for growth and can utilize hemoglobin and hemoglobin-haptoglobin as heme sources. We previously identified two hemoglobin- and hemoglobin-haptoglobin-binding proteins, HgpA and HgpB, in H. influenzae HI689. Insertional mutation of hgpA and hgpB, either singly or together, did not abrogate the ability to utilize or bind either hemoglobin or the hemoglobin-haptoglobin complex. A hemoglobin affinity purification method was used to isolate a protein of approxi...

  1. Diffusion coefficients of oxygen and hemoglobin as obtained simultaneously from photometric determination of the oxygenation of layers of hemoglobin solutions

    Spaan, J. A.; Kreuzer, F.; van Wely, F. K.

    1980-01-01

    The oxygenation of layers of deoxygenated hemoglobin solutions after a sudden exposure to a gas containing oxygen at a partial pressure P1 has been studied by a photometric method. Layer thicknesses varied between 50 and 250 micron, hemoglobin concentrations between 0.1 and 0.34kg/l, and oxygen

  2. Description of Three New α Variants and Four New β Variants: Hb Montluel [α110(G17)Ala → Val; HBA1: c.332C > T], Hb Cap d'Agde [α131(H14)Ser → Cys; HBA2: c.395C > G] and Hb Corsica [α100(G7)Leu → Pro; HBA1: 302T > C]; Hb Nîmes [β104(G6)Arg → Gly; HBB: c.313A > G], Hb Saint Marcellin [β112(G14)Cys → Gly; HBB: c.337T > G], Hb Saint Chamond [β80(EF4)Asn → 0; HBB: c.241_243delAAC] and Hb Dompierre [β29(B11)Gly → Arg; HBB: c.88G > C].

    Renoux, Céline; Feray, Cécile; Joly, Philippe; Lacan, Philippe; Francina, Alain

    2015-01-01

    We present here seven new hemoglobin (Hb) variants identified during routine Hb analysis. All of them are caused by a missense mutation except Hb Saint Chamond, which results from an in-frame deletion of the asparagine residue at β80. All these variants are clinically silent in the heterozygous state but two of them (Hb Cap d'Agde and Hb Dompierre) may be unstable, whereas Hb Nîmes could present a very slightly elevated oxygen affinity. These data are to be confirmed by appropriate biochemical tests.

  3. Histopathologic Study Following Administration of Liposome-Encapsulated Hemoglobin in the Normovolemic Rat

    Rudolph, Alan

    1995-01-01

    ... bovine hemoglobin in the normovolemic rat. We have also examined the administration of the liposome vehicle, tetrameric bovine hemoglobin, and liposome encapsulated bovine hemoglobin that had been lyophilized with 300 mM trehalose...

  4. Genomic organization and evolution of the Atlantic salmon hemoglobin repertoire

    Phillips Ruth B

    2010-10-01

    Full Text Available Abstract Background The genomes of salmonids are considered pseudo-tetraploid undergoing reversion to a stable diploid state. Given the genome duplication and extensive biological data available for salmonids, they are excellent model organisms for studying comparative genomics, evolutionary processes, fates of duplicated genes and the genetic and physiological processes associated with complex behavioral phenotypes. The evolution of the tetrapod hemoglobin genes is well studied; however, little is known about the genomic organization and evolution of teleost hemoglobin genes, particularly those of salmonids. The Atlantic salmon serves as a representative salmonid species for genomics studies. Given the well documented role of hemoglobin in adaptation to varied environmental conditions as well as its use as a model protein for evolutionary analyses, an understanding of the genomic structure and organization of the Atlantic salmon α and β hemoglobin genes is of great interest. Results We identified four bacterial artificial chromosomes (BACs comprising two hemoglobin gene clusters spanning the entire α and β hemoglobin gene repertoire of the Atlantic salmon genome. Their chromosomal locations were established using fluorescence in situ hybridization (FISH analysis and linkage mapping, demonstrating that the two clusters are located on separate chromosomes. The BACs were sequenced and assembled into scaffolds, which were annotated for putatively functional and pseudogenized hemoglobin-like genes. This revealed that the tail-to-tail organization and alternating pattern of the α and β hemoglobin genes are well conserved in both clusters, as well as that the Atlantic salmon genome houses substantially more hemoglobin genes, including non-Bohr β globin genes, than the genomes of other teleosts that have been sequenced. Conclusions We suggest that the most parsimonious evolutionary path leading to the present organization of the Atlantic salmon

  5. Genomic organization and evolution of the Atlantic salmon hemoglobin repertoire

    2010-01-01

    Background The genomes of salmonids are considered pseudo-tetraploid undergoing reversion to a stable diploid state. Given the genome duplication and extensive biological data available for salmonids, they are excellent model organisms for studying comparative genomics, evolutionary processes, fates of duplicated genes and the genetic and physiological processes associated with complex behavioral phenotypes. The evolution of the tetrapod hemoglobin genes is well studied; however, little is known about the genomic organization and evolution of teleost hemoglobin genes, particularly those of salmonids. The Atlantic salmon serves as a representative salmonid species for genomics studies. Given the well documented role of hemoglobin in adaptation to varied environmental conditions as well as its use as a model protein for evolutionary analyses, an understanding of the genomic structure and organization of the Atlantic salmon α and β hemoglobin genes is of great interest. Results We identified four bacterial artificial chromosomes (BACs) comprising two hemoglobin gene clusters spanning the entire α and β hemoglobin gene repertoire of the Atlantic salmon genome. Their chromosomal locations were established using fluorescence in situ hybridization (FISH) analysis and linkage mapping, demonstrating that the two clusters are located on separate chromosomes. The BACs were sequenced and assembled into scaffolds, which were annotated for putatively functional and pseudogenized hemoglobin-like genes. This revealed that the tail-to-tail organization and alternating pattern of the α and β hemoglobin genes are well conserved in both clusters, as well as that the Atlantic salmon genome houses substantially more hemoglobin genes, including non-Bohr β globin genes, than the genomes of other teleosts that have been sequenced. Conclusions We suggest that the most parsimonious evolutionary path leading to the present organization of the Atlantic salmon hemoglobin genes involves

  6. [On the medical and publishing activities of the community of Saint Eugene].

    2012-01-01

    The article deals with the role the physicians played in organization and functioning of the Community of Saint Eugene in St. Petersburg in 1882-1918. The typography production of the Community being of interest for history of medicine is examined.

  7. A School-Based Enterprise: The Saint Pauls, North Carolina Experience.

    Paquin, Thomas F.

    1991-01-01

    The superintendent of Saint Pauls Schools describes how educators, community leaders, businesspersons, and high school students worked together to develop the Way Off Broadway Deli, a successful school-based enterprise providing experiential education in entrepreneurship and small business management, as well as student employment and local…

  8. The first leg transplant for the treatment of a cancer by Saints Cosmas and Damian.

    Androutsos, G; Diamantis, A; Vladimiros, L

    2008-01-01

    The most renowned of all medically inclined saints must have been St. Cosmas and St. Damian. They became the special patrons of surgery, due to their miraculous operations. On one occasion, they amputated a cancerous leg and replaced it with another, taken from a Moor who had just died. This dramatic cure was meat and drink for artists, and has been portrayed many times.

  9. Ciguatera fish poisoning in an international ship crew in Saint John Canada: 2015.

    Muecke, C; Hamper, L; Skinner, A L; Osborne, C

    2015-11-05

    An international ship crew presented for medical care in Saint John, New Brunswick, following rapid onset of gastrointestinal and in some cases neurological and cardiac symptoms after a common fish meal. Ciguatera poisoning was identified as the cause of illness. This report describes the public health investigation and management of this incident, including collaboration between the implicated provincial and federal authorities.

  10. Enhancing the IT Infrastructure at Saint Philip's Hospital: Point-of-Care Solutions

    Naydenova, Iva; White, Bruce

    2013-01-01

    Healthcare has become a rapidly changing field. With the introduction of value-based purchasing to determine reimbursement of Medicare providers based on the quality of care in addition to outcomes in treatment, the environment is becoming ever more competitive. Saint Philip's Hospital is among the largest non-profit hospitals in the nation…

  11. Baking the Bread and Roasting the Meat : Dorlandus's Saint Lawrence as a model for Carthusians

    van Dijk, Mathilde

    2018-01-01

    The two sermons on Saint Lawrence by the profilic Carthusian author Petrus Dorlandus survive in a manuscript from the charterhouse in Louvain, which was used for reading at table. Dorlandus’s development of the well-known tale about this martyr is geared to this practice. Inviting his fellow

  12. A Latter-day Saint Approach to Addiction: Aetiology, Consequences and Treatment in a Theological Context

    James D. Holt

    2014-12-01

    Full Text Available This article explores the theological underpinning of the nature, aetiology and treatment of addictions within The Church of Jesus Christ of Latter-day Saints. The first section outlines the “plan of salvation” and how this provides the theological framework for the source and solution to addictions. The final section explores addiction against this background in terms of its aetiology, types, consequences and treatment in a Latter-day Saint context. In so doing it builds on the recognition by the Church in recent years that addiction is a problem in the lives of some of its members and that treatment programs coherent with its teachings and beliefs are necessary. The article concludes by suggesting that while addiction may be more openly discussed within a Latter-day Saint context there is a need to keep this dialogue moving forward. This article does not examine Latter-day Saint teaching within the wider context of psychotherapy and other definitions of addiction; rather it explores the place of addiction as understood within the theological and ecclesiological context of Mormonism.

  13. The eleventh CRL-Salmonella workshop, 9 May 2006, Saint Malo, France

    Mooijman KA; MGB

    2006-01-01

    De elfde workshop georganiseerd door het Communautair Referentie Laboratorium voor Salmonella (CRL-Salmonella) werd gehouden op 9 mei 2006 in Saint Malo, Frankrijk. Deelnemers waren vertegenwoordigers van de nationale Referentie Laboratoria voor Salmonella (NRLs-Salmonella) van de lidstaten van de

  14. Saint Francis Xavier on Jesuit School Stages of the Bohemian Province

    Bobková, Kateřina; Jacková, Magdaléna

    2015-01-01

    Roč. 25, č. 2 (2015), s. 135-155 ISSN 0515-3190 R&D Projects: GA ČR GPP406/12/P823 Institutional support: RVO:68378068 ; RVO:67985963 Keywords : St. Francis Xavier * Jesuit saints * Jesuit theatre * neolatin drama * school theatre * Avancini, Nicolaus * Engel, Arnoldus Subject RIV: AJ - Letters, Mass-media, Audiovision; AB - History (HIU-Y)

  15. De Manet a Yves Saint-Laurent: uma análise semiótica

    Christiane Paula Godinho Santarelli

    2008-09-01

    Full Text Available A proposta deste artigo é fazer uma análise semiótica, com base na teoria greimasiana, da pintura original de Manet Le déjeuner sur l’herbe e de sua recriação para o anúncio da marca Yves Saint-Laurent. Os aspectos analisados nos dois “textos” são: os sistemas de valores, a estrutura narrativa, a estrutura de poder, os objetos de valor e a semântica profunda. A comparação dos dois discursos tem como objetivo atentar para as contradições no suposto discurso libertador da publicidade de Yves Saint-Laurent, que pode estar presente na publicidade de outras marcas. Palavras-chave: Publicidade; semiótica; arte; moda. ABSTRACT The purpose of this article is to offer a semiotical analysis of the original painting of Manet Le déjeuner sur l’herbe and of its recreation in an advertisement for the brand Yves Saint-Laurent. The aspects analyzed in the two “texts” are: the systems of enclosed values, the narrative structure, the power structure, the objects of value and deep semantics. The comparison between the two forms of speech aims to highlight the contradictions in the alleged liberating speech of the Yves Saint-Laurent advertisement, which may be present in advertising pieces from other brands. Keywords: Advertising; semiotics; art; fashion.

  16. Changes in the Population Distribution and Transport Network of Saint Petersburg

    Xiaoling Li

    2016-12-01

    Full Text Available The authors explores the interdependence between demographic changes and transport network centrality, using Saint Petersburg as an example. The article describes the demographic data for the period 2002—2015 and the transportation network data of 2006. The authors employ several methods of demographic research; they identified the centre of gravity of the population, produce the standard deviational ellipsis and use the kernel density estimation. The street network centrality of Saint Petersburg was analyzed using the Multiple Centrality Assessment Model (MCA and the Urban Network Analysis Tool for ArcGIS. The analysis of the population distribution in Saint Petersburg shows that each area of the city has seen their population grow over the last thirteen years. However, it is the population of suburban areas that increased the most. The core area of the city has the tendency of outward diffusion, and the population gravity centre has been moving northwards. Spatial characteristics of the population growth, changes in the population gravity centre, the standard deviational ellipse and characteristics of the street network centrality show that Saint Petersburg is at the final stage of urbanization and its development pattern is similar to that of other major cities.

  17. Baldrige Award cites two hospitals. Baptist, Saint Luke's hospitals honored for quality, performance.

    Rees, Tom

    2004-01-01

    Baptist Hospital Inc., Pensacola, Fla.; and Saint Luke's Hospital, Kansas City, Mo., have received the prestigious Malcolm Baldrige National Quality Award in the category of healthcare. Named for a former secretary of commerce, the award recognizes efficiency, effectiveness and excellence. The two hospitals are among only seven companies in the U.S. to be so recognized this year.

  18. Evaluation of OPPS model for plant operator's task simulation with Micro-SAINT

    Yoshida, Kazuo

    1991-03-01

    The development of a computer simulation method for cognitive behavior of operators under emergency conditions in nuclear power plant are being conducted at Japan Atomic Energy Research Institute (JAERI). As one of activities in this project, the task network modeling and simulation method has been evaluated with reproduced OPPS model using Micro-SAINT which is a PC software for task network analysis. OPPS is an operator's task simulation model developed by Oak Ridge National Laboratory. Operator's tasks under the condition of failure open of a safety relief valve in a BWR power plant has been analyzed as a sample problem with Micro-SAINT version of OPPS for the evaluation of task network analysis method. Furthermore, the fundamental capabilities of Micro-SAINT has been evaluated, and the task network in OPPS model has been also examined. As the results of this study, it has been clarified that random seed numbers in Micro-SAINT affect the probabilistic branching ratio and the distribution of task execution time calculated by Monte Carlo simulations, and the expression of network for a repeated task in the OPPS model leads to incorrect standard deviation in the case that a task execution time has some distribution. (author)

  19. Un solveur HLLT pour les equations de Saint-Venant et traitement ...

    Un solveur HLLT pour les equations de Saint-Venant et traitement des ... Enfin, des applications numériques sur des cas tests sont présentées. ... the system of partial-differential equations is completed by a trivial equation for the bathymetry.

  20. Un solveur HLLTpour les equations de Saint-vVenant et traitement ...

    Un solveur HLLTpour les equations de Saint-vVenant et traitement des ... Enfin, des applications numériques sur des cas tests sont présentées. ... the system of partial-differential equations is completed by a trivial equation for the bathymetry.

  1. Further contributions to a new tectonic interpretation of the Sainte Victoire Mountain (Provence, France)

    Ricour, J.; Monteau, R.; Laville, P.; Agryriadis, I.

    2016-10-01

    A new tectonic interpretation of the Sainte Victoire Mountain (north of Marseille, south eastern France) is proposed, principally invoking vertical movements and providing evidence which suggests an uplift which may be still active today in the western part. Some new observations confirm our hypothesis. (Author)

  2. Latter-Day Saint Women and Leadership: The Influence of Their Religious Worldview

    Madsen, Susan R.

    2016-01-01

    The article examines theories, assumptions, concepts, experiences, and practices from the Latter-day Saints' (LDS, or the Mormons) religious worldview to expand existing theoretical constructs and implications of leadership development and education for women. The article elucidates LDS doctrine and culture regarding women and provides specific…

  3. The Slavonic Translation of the Life of Saint Euthymius the Great: Observations on Language and Authorship

    Dmitriy Evgenyevich Afinogenov

    2015-10-01

    Full Text Available The Slavonic translation of the Life of Saint Euthymius the Great (BHG 647 by Cyril of Scythopolis, attested at the earliest manuscript of the late 14th c., was probably made by a person originating from South-East Rus in the 11th c., as it displays some grammatical, lexical, and phonetic features peculiar for this area and time, and visible, in particular, in Ipatiev Chronicle and the Tale of Igor’s Campaign. It may have formed a part of the collection comprising several writings by Cyril, including the Life of Saint Sabas and the Praise of Euthymius and Sabas (lost in the Greek original. This collection was later incorporated into the Great Lectionary Menologion of Metropolitan Makarij. The details added by the translator to the description of certain realia pertaining to the Monastery of Saint Euthymius in Palestine suggest a personal knowledge of that monastic complex (the Laura and the coenobium. The proposed author of the translation is Saint Anthony of the Cave Monastery in Kiev († 1073, who could perfectly well have visited the Holy Land during his stay on Mount Athos prior to 1051.

  4. Two-photon excited fluorescence emission from hemoglobin

    Sun, Qiqi; Zeng, Yan; Zhang, Wei; Zheng, Wei; Luo, Yi; Qu, Jianan Y.

    2015-03-01

    Hemoglobin, one of the most important proteins in blood, is responsible for oxygen transportation in almost all vertebrates. Recently, we discovered two-photon excited hemoglobin fluorescence and achieved label-free microvascular imaging based on the hemoglobin fluorescence. However, the mechanism of its fluorescence emission still remains unknown. In this work, we studied the two-photon excited fluorescence properties of the hemoglobin subunits, heme/hemin (iron (II)/(III) protoporphyrin IX) and globin. We first studied the properties of heme and the similar spectral and temporal characteristics of heme and hemoglobin fluorescence provide strong evidence that heme is the fluorophore in hemoglobin. Then we studied the fluorescence properties of hemin, globin and methemoglobin, and found that the hemin may have the main effect on the methemoglobin fluorescence and that globin has tryptophan fluorescence like other proteins. Finally, since heme is a centrosymmetric molecule, that the Soret band fluorescence of heme and hemoglobin was not observed in the single photon process in the previous study may be due to the parity selection rule. The discovery of heme two-photon excited fluorescence may open a new window for heme biology research, since heme as a cofactor of hemoprotein has many functions, including chemical catalysis, electron transfer and diatomic gases transportation.

  5. Quantifying risk of penile prosthesis infection with elevated glycosylated hemoglobin.

    Wilson, S K; Carson, C C; Cleves, M A; Delk, J R

    1998-05-01

    Elevation of glycosylated hemoglobin above levels of 11.5 mg.% has been considered a contraindication to penile prosthesis implantation in diabetic patients. We determine the predictive value of glycosylated hemoglobin A1C in penile prosthesis infections in diabetic and nondiabetic patients to confirm or deny this prevalent opinion. We conducted a 2-year prospective study of 389 patients, including 114 diabetics, who underwent 3-piece penile prosthesis implantation. All patients had similar preoperative preparation without regard to diabetic status, control or glycosylated hemoglobin A1C level. Risk of infection was statistically analyzed for diabetics versus nondiabetics, glycosylated hemoglobin A1C values above and below 11.5 mg.%, insulin dependent versus oral medication diabetics, and fasting blood sugars above and below 180 mg.%. Prosthesis infections developed in 10 diabetics (8.7%) and 11 nondiabetics (4.0%). No increased infection rate was observed in diabetics with high fasting sugars or diabetics on insulin. There was no statistically significant increased infection risk with increased levels of glycosylated hemoglobin A1C among all patients or among only the diabetics. In fact, there was no meaningful difference in the median or mean level of glycosylated hemoglobin A1C in the infected and noninfected patients regardless of diabetes. Use of glycosylated hemoglobin A1C values to identify and exclude surgical candidates with increased risk of infections is not proved by this study. Elevation of fasting sugar or insulin dependence also does not increase risk of infection in diabetics undergoing prosthesis implantation.

  6. Postoperative hemoglobin level in patients with femoral neck fracture.

    Nagra, Navraj S; Van Popta, Dmitri; Whiteside, Sigrid; Holt, Edward M

    2016-01-01

    The aim of this study was to analyze the changes of hemoglobin levels in patients undergoing fixation for femoral neck fracture. Peroperative hemoglobin levels of patients who underwent either dynamic hip screw (DHS) fixation (n=74; mean age: 80 years) or hip hemiarthroplasty (n=104; mean age: 84 years) for femoral neck fracture was monitored. There was a statistically and clinically significant mean drop of 31.1 g/L between the preoperative (D0) and postoperative Day 5 Hb levels (pmeasurement, DHS patients had lower hemoglobin values over hemiarthroplasty patients (p=0.046). The decrease in hemoglobin in the first 24-hour postoperative period (D0 to Day 1) is an underestimation of the ultimate lowest value in hemoglobin found at Day 2. Relying on the Day 1 hemoglobin level could be detrimental to patient care. We propose a method of predicting patients likely to be transfused and recommend a protocol for patients undergoing femoral neck fracture surgery to standardize postoperative hemoglobin monitoring.

  7. Expression of fully functional tetrameric human hemoglobin in Escherichia coli

    Hoffman, S.J.; Looker, D.L.; Roehrich, J.M.; Cozart, P.E.; Durfee, S.L.; Tedesco, J.L.; Stetler, G.L.

    1990-01-01

    Synthesis genes encoding the human α- and β-globin polypeptides have been expressed from a single operon in Escherichia coli. The α- and β-globin polypeptides associate into soluble tetramers, incorporate heme, and accumulate to >5% of the total cellular protein. Purified recombinant hemoglobin has the correct stoichiometry of α- and β-globin chains and contains a full complement of heme. Each globin chain also contains an additional methionine as an extension to the amino terminus. The recombinant hemoglobin has a C 4 reversed-phase HPLC profile essentially identical to that of human hemoglobin A 0 and comigrates with hemoglobin A 0 on SDS/PAGE. The visible spectrum and oxygen affinity are similar to that of native human hemoglobin A 0 . The authors have also expressed the α- and β-globin genes separately and found that the expression of the α-globin gene alone results in a marked decrease in the accumulation of α-globin in the cell. Separate expression of the β-globin gene results in high levels of insoluble β-globin. These observations suggest that the presence of α- and β-globin in the same cell stabilizes α-globin and aids the correct folding of β-globin. This system provides a simple method for expressing large quantities of recombinant hemoglobin and allows facile manipulation of the genes encoding hemoglobin to produce functionally altered forms of this protein

  8. Using the MWC model to describe heterotropic interactions in hemoglobin

    Rapp, Olga

    2017-01-01

    Hemoglobin is a classical model allosteric protein. Research on hemoglobin parallels the development of key cooperativity and allostery concepts, such as the ‘all-or-none’ Hill formalism, the stepwise Adair binding formulation and the concerted Monod-Wymann-Changuex (MWC) allosteric model. While it is clear that the MWC model adequately describes the cooperative binding of oxygen to hemoglobin, rationalizing the effects of H+, CO2 or organophosphate ligands on hemoglobin-oxygen saturation using the same model remains controversial. According to the MWC model, allosteric ligands exert their effect on protein function by modulating the quaternary conformational transition of the protein. However, data fitting analysis of hemoglobin oxygen saturation curves in the presence or absence of inhibitory ligands persistently revealed effects on both relative oxygen affinity (c) and conformational changes (L), elementary MWC parameters. The recent realization that data fitting analysis using the traditional MWC model equation may not provide reliable estimates for L and c thus calls for a re-examination of previous data using alternative fitting strategies. In the current manuscript, we present two simple strategies for obtaining reliable estimates for MWC mechanistic parameters of hemoglobin steady-state saturation curves in cases of both evolutionary and physiological variations. Our results suggest that the simple MWC model provides a reasonable description that can also account for heterotropic interactions in hemoglobin. The results, moreover, offer a general roadmap for successful data fitting analysis using the MWC model. PMID:28793329

  9. Individualized anemia management reduces hemoglobin variability in hemodialysis patients.

    Gaweda, Adam E; Aronoff, George R; Jacobs, Alfred A; Rai, Shesh N; Brier, Michael E

    2014-01-01

    One-size-fits-all protocol-based approaches to anemia management with erythropoiesis-stimulating agents (ESAs) may result in undesired patterns of hemoglobin variability. In this single-center, double-blind, randomized controlled trial, we tested the hypothesis that individualized dosing of ESA improves hemoglobin variability over a standard population-based approach. We enrolled 62 hemodialysis patients and followed them over a 12-month period. Patients were randomly assigned to receive ESA doses guided by the Smart Anemia Manager algorithm (treatment) or by a standard protocol (control). Dose recommendations, performed on a monthly basis, were validated by an expert physician anemia manager. The primary outcome was the percentage of hemoglobin concentrations between 10 and 12 g/dl over the follow-up period. A total of 258 of 356 (72.5%) hemoglobin concentrations were between 10 and 12 g/dl in the treatment group, compared with 208 of 336 (61.9%) in the control group; 42 (11.8%) hemoglobin concentrations were hemoglobin concentrations were >12 g/dl in the treatment group compared with 46 (13.4%) in the control group. The median ESA dosage per patient was 2000 IU/wk in both groups. Five participants received 6 transfusions (21 U) in the treatment group, compared with 8 participants and 13 transfusions (31 U) in the control group. These results suggest that individualized ESA dosing decreases total hemoglobin variability compared with a population protocol-based approach. As hemoglobin levels are declining in hemodialysis patients, decreasing hemoglobin variability may help reduce the risk of transfusions in this population.

  10. Relationship between maternal hemoglobin and perinatal outcome

    Bakhtiar, U.J.; Khan, Y.; Nisar, R.

    2007-01-01

    To Study the Relationship between Maternal Hemoglobin and Perinatal outcome in a cohort of 860 pregnant women and to highlight the importance of antenatal care regarding maternal health and fetal outcome. All Singleton pregnancies delivering at Pakistan Railway Hospital Rawalpindi from January 2004 to December 2005 that fulfilled the required criteria were included. Out of the 860 patients, 402 were anemic (<11gm/dl) and 458 were non anemic. Perinatal outcome included preterm delivery, low birth weight, intrauterine growth retardation, perinatal death, low apgr scores and intrauterine fetal deaths. Risk of preterm and Low birth weight among anemic women was 3.4 and 1.8 times more than non anaemic women. The neonates of anemic woman also had 1.7 times increased risk of having low apgr scores at 1 min. Among anemic women there was 2.2 times greater risk of intrauterine fetal death than the non-anemic women. Regular antenatal care from first trimester has a vital role in assessing and managing maternal anemia timely and it directly affects the perinatal outcome. The patients with anemia have also higher risk of having low birth weight, preterm births and intra uterine fetal death. (author)

  11. NITRO MUSK BOUND TO CARP HEMOGLOBIN ...

    Nitroaromatic compounds including synthetic nitro musks are important raw materials and intermediates in the synthesis of explosives, dyes, and pesticides, pharmaceutical and personal care-products (PPCPs). The nitro musks such as musk xylene (MX) and musk ketone (MK) are extensively used as fragrance ingredients in PPCPs and other commercial toiletries. Identification and quantification of a bound 4-amino-MX (4-AMX) metabolite as well as a 2- amino-MK (2-AMK) metabolite were carried out by gas chromatography-mass spectrometry' (GC/MS), with selected ion monitoring (SIM) in both the electron ionization (ElMS) and electron capture (EC) negative ion chemical ionization (NICIMS) modes. Detection of 4-AMX and 2-AMK occurred after the cysteine adducts in carp hemoglobin, derived from the nitroso metabolites, were released by alkaline hydrolysis. The released metabolites were extracted into n-hexane. The extract was preconcentrated by evaporation, and analyzed by GC-SIM-MS. A comparison between the El and EC approaches was made. EC NICIMS detected both metabolites whereas only 4-AMX was detected by ElMS. The EC NICIMS approach exhibited fewer matrix responses and provided a lower detection limit. Quantitation in both approaches was based on internal standard and a calibration plot. The research focused on in the subtasks is the development and application of state-of the-art technologies to meet the needs of the public, Office of Water, and ORD in the area of Water Q

  12. Noninvasive hemoglobin measurement using dynamic spectrum

    Yi, Xiaoqing; Li, Gang; Lin, Ling

    2017-08-01

    Spectroscopy methods for noninvasive hemoglobin (Hgb) measurement are interfered by individual difference and particular weak signal. In order to address these problems, we have put forward a series of improvement methods based on dynamic spectrum (DS), including instrument design, spectrum extraction algorithm, and modeling approach. The instrument adopts light sources composed of eight laser diodes with the wavelength range from 600 nm to 1100 nm and records photoplethysmography signals at eight wavelengths synchronously. In order to simplify the optical design, we modulate the light sources with orthogonal square waves and design the corresponding demodulation algorithm, instead of adopting a beam-splitting system. A newly designed algorithm named difference accumulation has been proved to be effective in improving the accuracy of dynamic spectrum extraction. 220 subjects are involved in the clinical experiment. An extreme learning machine calibration model between the DS data and the Hgb levels is established. Correlation coefficient and root-mean-square error of prediction sets are 0.8645 and 8.48 g/l, respectively. The results indicate that the Hgb level can be derived by this approach noninvasively with acceptable precision and accuracy. It is expected to achieve a clinic application in the future.

  13. Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy

    Iván González

    2017-01-01

    Full Text Available Evans syndrome (ES is a rare autoimmune disorder whose exact pathophysiology is unknown. It is characterized by the simultaneous or subsequent development of autoimmune hemolytic anemia (AIHA and immune thrombocytopenia (ITP. Intravascular hemolysis, with hemoglobinemia, is known to produce acute kidney injury; however, the development of intratubular hemoglobin casts (hemoglobin cast nephropathy in the setting of acute hemolysis is uncommon. Likewise, the association of ES and acute renal failure is equally uncommon. We present a case of a 7-year-old girl with ES who developed acute kidney injury in the setting of intravascular hemolysis and had widespread intratubular hemoglobin casts.

  14. Biophysical basis of hypoxic radioprotection by deoxygenated dextran-hemoglobin

    Wong, J.T.; Hill, R.P.

    1986-01-01

    Perfusion with deoxygenated dextran-hemoglobin provides an effective method for inducing hypoxic radioprotection of normal tissues during radiation treatment of tumors. In this study, the dependence of P50, the half-saturation pressure of oxygen binding to dextran-hemoglobin, was analyzed as a function of solution temperature and pH. The variation of attainable radioprotection with P50, and with the amount of collateral blood entering into the perfused region, was calculated. Upon perfusion of canine gracilis muscle with deoxygenated dextran-hemoglobin, a rapid onset of extensive venous hypoxia was observed

  15. Symbiotic and nonsymbiotic hemoglobin genes of Casuarina glauca

    Jacobsen-Lyon, K; Jensen, Erik Østergaard; Jørgensen, Jan-Elo

    1995-01-01

    Casuarina glauca has a gene encoding hemoglobin (cashb-nonsym). This gene is expressed in a number of plant tissues. Casuarina also has a second family of hemoglobin genes (cashb-sym) expressed at a high level in the nodules that Casuarina forms in a nitrogen-fixing symbiosis with the actinomycete...... of the Casuarina gene. The finding that the nonsymbiotic Casuarina gene is also correctly expressed in L. corniculatus suggests to us that a comparable non-symbiotic hemoglobin gene will be found in legume species. Udgivelsesdato: 1995-Feb...

  16. 21 CFR 866.5470 - Hemoglobin immunological test system.

    2010-04-01

    .... Measurements of free hemoglobin aid in the diagnosis of various hematologic disorders, such as sickle cell... blood cells), and leukemia (cancer of the blood-forming organs). (b) Classification. Class II...

  17. A nanocluster-based fluorescent sensor for sensitive hemoglobin detection.

    Yang, Dongqin; Meng, Huijie; Tu, Yifeng; Yan, Jilin

    2017-08-01

    In this report, a fluorescence sensor for sensitive detection of hemoglobin was developed. Gold nanoclusters were first synthesized with bovine serum albumin. It was found that both hydrogen peroxide and hemoglobin could weakly quench the fluorescence from the gold nanoclusters, but when these two were applied onto the nanolcusters simultaneously, a much improved quenching was resulted. This enhancing effect was proved to come from the catalytic generation of hydroxyl radical by hemoglobin. Under an optimized condition, the quenching linearly related to the concentration of hemoglobin in the range of 1-250nM, and a limit of detection as low as 0.36nM could be obtained. This provided a sensitive means for the quantification of Hb. The sensor was then successfully applied for blood analyses with simple sample pretreatment. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Novel subunit structure observed for noncooperative hemoglobin from Urechis caupo.

    Kolatkar, P R; Meador, W E; Stanfield, R L; Hackert, M L

    1988-03-05

    Tetrameric hemoglobin from the "fat innkeeper" worm Urechis caupo possesses a novel subunit arrangement having an "inside out" quaternary structure in that the G/H helices are located on the outer surface of the tetramer. A 5-A resolution crystal structure reveals that although the individual subunits are beta-like, having a distinct D helix and the general myoglobin fold, the subunit contacts are very different from those previously observed for hemoglobins. Furthermore, the hemoglobin from U. caupo is also quite different from the unusual hemoglobin tetramer from clam which also has its G/H helices on the outer surface but with the hemes in close proximity through E-F helical contacts (Royer, W. E., Jr., Love, W. E., and Fenderson, F. F. (1985) Nature 316, 277-280).

  19. The influence of socioeconomic status on the hemoglobin level and ...

    Conclusion: Poor socioeconomic status has an adverse effect on the nutritional status and hemoglobin of SCA patients. ... Date of Acceptance: 15-Mar-2011 ..... This study was designed to determine the relationship .... mobiles and devices.

  20. Hemoglobin as a factor in the control of tumor oxygenation

    Hirst, D.G.

    1987-01-01

    The concentration of hemoglobin in the blood has been shown to have a market effect on the radiosensitivity of human and animal tumors. Experimental studies in mice indicate that radiosensitivity is influenced by a change in the hemoglobin level rather than by the absolute concentration. This dependence may be exploited to therapeutic advantage. Recent studies of hemoglobin/oxygen affinity have shown that the concentration of 2,3 diphosphoglycerate (2,3 DPG) affects tumor sensitivity to X-rays. Increased 2,3 DPG levels increase radiosensitivity in several mouse tumors. The time dependence of this effect remains to be established. The effective application of these effects in man may depend on the development of drugs which produce changes in hemoglobin affinity without the need for blood transfusions. Several drugs are currently being investigated

  1. Manipulation of hemoglobin expression affects Arabidopsis shoot organogenesis

    Wang, Yaping; Elhiti, Mohamed; Hebelstrup, Kim

    2011-01-01

    Over the past few years non-symbiotic plant hemoglobins have been described in a variety of plant species where they fulfill several functions ranging from detoxification processes to basic aspects of plant growth and post-embryonic development. To date no information is available on the role...... of hemoglobins during invitro morphogenesis. Shoot organogenesis was induced in Arabidopsis lines constitutively expressing class 1, 2 and 3 hemoglobins (GLB1, 2 and 3) and lines in which the respective genes were either downregulated by RNAi (GLB1) or knocked out (GLB2 and GLB3). The process was executed......, 15, and 16), feed-back repressors of the cytokinin pathway, was repressed in both hemoglobin over-expressors whereas that of several Type-B ARRs (ARR2, 12, and 13), transcription activators of cytokinin-responsive genes, was induced. Such changes enhanced the sensitivity of the root explants...

  2. Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock

    Holst, Lars B; Haase, Nicolai; Wetterslev, Jørn

    2014-01-01

    BACKGROUND: Blood transfusions are frequently given to patients with septic shock. However, the benefits and harms of different hemoglobin thresholds for transfusion have not been established. METHODS: In this multicenter, parallel-group trial, we randomly assigned patients in the intensive care...... unit (ICU) who had septic shock and a hemoglobin concentration of 9 g per deciliter or less to receive 1 unit of leukoreduced red cells when the hemoglobin level was 7 g per deciliter or less (lower threshold) or when the level was 9 g per deciliter or less (higher threshold) during the ICU stay...... were similar in the two intervention groups. CONCLUSIONS: Among patients with septic shock, mortality at 90 days and rates of ischemic events and use of life support were similar among those assigned to blood transfusion at a higher hemoglobin threshold and those assigned to blood transfusion...

  3. Direct electrochemistry of hemoglobin entrapped in dextran film on ...

    Administrator

    28. Li et al used single- walled carbon nanotube (SWCNT) and 1-hexyl-3- ... Electrochemistry of dextran/hemoglobin/carbon ionic liquid electrode. 273. 2.4 Procedures ..... used for the construction of H2O2 biosensor. Acknowledgement.

  4. Temperature-dependent enthalpy of oxygenation in Antarctic fish hemoglobins

    Fago, A.; Wells, R.M.G.; Weber, Roy E.

    1997-01-01

    The effect of temperature on the oxygen-binding properties of the hemoglobins of three cold-adapted Antarctic fish species, Dissostichus mawsoni, Pagothenia borchgrevinki and Trematomus, sp., has been investigated under different pH values and buffer conditions. A clear non linear van't Hoff plot...... (logP(50) vs 1/T) of D. mawsoni hemoglobin indicates that the enthalpy of oxygenation (slope of the plot) is temperature dependent and that at high temperatures oxygen-binding becomes less exothermic. Nearly linear relationships were found in the hemoglobins of the other two species. The data were...... oxygen binding. The degree of the temperature dependence of the heat of oxygenation observed in these hemoglobins seems to reflect the differences in their allosteric effects rather than a specific molecular adaptation to low temperatures. Moreover, this study indicates that the disagreement between...

  5. Receptor targeting of hemoglobin mediated by the haptoglobins

    Nielsen, Marianne Jensby; Moestrup, Søren Kragh

    2009-01-01

    Haptoglobin, the haptoglobin-hemoglobin receptor CD163, and the heme oxygenase-1 are proteins with a well-established function in the clearance and metabolism of "free" hemoglobin released during intravascular hemolysis. This scavenging system counteracts the potentially harmful oxidative and NO......-scavenging effects associated with "free" hemoglobin, and, furthermore, elicits an anti-inflammatory response. In the late primate evolution, haptoglobin variants with distinct functions have arisen, including haptoglobin polymers and the haptoglobin-related protein. The latter associates with a subspecies of high......-density lipoprotein (HDL) particles playing a crucial role in the innate immunity against certain trypanosome parasites. Recent studies have elucidated this fairly sophisticated immune defense mechanism that takes advantage of a trypanosomal haptoglobin-hemoglobin receptor evolved to supply the parasite with heme...

  6. Effects of thyroid status on glycated hemoglobin

    Rana Bhattacharjee

    2017-01-01

    Full Text Available Introduction: Glycated hemoglobin (HbA1c can be altered in different conditions. We hypothesize that HbA1c levels may change due to altered thyroid status, possibly due to changes in red blood cell (RBC turnover. Objectives: The objective of this study was to determine the effects of altered thyroid status on HbA1c levels in individuals without diabetes, with overt hyper- and hypo-thyroidism, and if present, whether such changes in HbA1c are reversed after achieving euthyroid state. Methods: Euglycemic individuals with overt hypo- or hyper-thyroidism were selected. Age- and sex-matched controls were recruited. Baseline HbA1c and reticulocyte counts (for estimation of RBC turnover were estimated in all the patients and compared. Thereafter, stable euthyroidism was achieved in a randomly selected subgroup and HbA1c and reticulocyte count was reassessed. HbA1c values and reticulocyte counts were compared with baseline in both the groups. Results: Hb A1c in patients initially selected was found to be significantly higher in hypothyroid group. HbA1c values in hyperthyroid patients were not significantly different from controls. HbA1c reduction and rise in reticulocyte count were significant in hypothyroid group following treatment without significant change in glucose level. Hb A1c did not change significantly following treatment in hyperthyroid group. The reticulocyte count, however, decreased significantly. Conclusion: Baseline HbA1c levels were found to be significantly higher in hypothyroid patients, which reduced significantly after achievement of euthyroidism without any change in glucose levels. Significant baseline or posttreatment change was not observed in hyperthyroid patients. Our study suggests that we should be cautious while interpreting HbA1c data in patients with hypothyroidism.

  7. Oxygen binding to partially nitrosylated hemoglobin.

    Fago, Angela; Crumbliss, Alvin L; Hendrich, Michael P; Pearce, Linda L; Peterson, Jim; Henkens, Robert; Bonaventura, Celia

    2013-09-01

    Reactions of nitric oxide (NO) with hemoglobin (Hb) are important elements in protection against nitrosative damage. NO in the vasculature is depleted by the oxidative reaction with oxy Hb or by binding to deoxy Hb to generate partially nitrosylated Hb (Hb-NO). Many aspects of the formation and persistence of Hb-NO are yet to be clarified. In this study, we used a combination of EPR and visible absorption spectroscopy to investigate the interactions of partially nitrosylated Hb with O2. Partially nitrosylated Hb samples had predominantly hexacoordinate NO-heme geometry and resisted oxidation when exposed to O2 in the absence of anionic allosteric effectors. Faster oxidation occurred in the presence of 2,3-diphosphoglycerate (DPG) or inositol hexaphosphate (IHP), where the NO-heme derivatives had higher levels of pentacoordinate heme geometry. The anion-dependence of the NO-heme geometry also affected O2 binding equilibria. O2-binding curves of partially nitrosylated Hb in the absence of anions were left-shifted at low saturations, indicating destabilization of the low O2 affinity T-state of the Hb by increasing percentages of NO-heme, much as occurs with increasing levels of CO-heme. Samples containing IHP showed small decreases in O2 affinity, indicating shifts toward the low-affinity T-state and formation of inert α-NO/β-met tetramers. Most remarkably, O2-equilibria in the presence of the physiological effector DPG were essentially unchanged by up to 30% NO-heme in the samples. As will be discussed, under physiological conditions the interactions of Hb with NO provide protection against nitrosative damage without impairing O2 transport by Hb's unoccupied heme sites. This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Hemoglobin concentrations and associated factors in adolescentes from Recife, Brazil

    Elisângela Barros Soares Mendonça; Lilian Ferreira Muniz; Ilma Kruze Grande de Arruda; Alcides da Silva Diniz

    2014-01-01

    OBJECTIVE: To estimate the prevalence of anemia and associated factors in adolescents from the city of Recife in Pernambuco state. METHODS: This is a cross-sectional study, involving a random sample of 256 adolescents of both genders, aged 13 to 18, whose hemoglobin concentrations were evaluated, along with their nutritional status and socioeconomic and demographic characteristics. RESULTS: The prevalence of inadequate hemoglobin concentrations was 10.2% [CI95%=6.7-14.5], reaching levels cons...

  9. Thalassemia and Hemoglobin E in Southern Thai Blood Donors

    Nuinoon, Manit; Kruachan, Kwanta; Sengking, Warachaya; Horpet, Dararat; Sungyuan, Ubol

    2014-01-01

    Thalassemia and hemoglobin E (Hb E) are common in Thailand. Individuals with thalassemia trait usually have a normal hemoglobin concentration or mild anemia. Therefore, thalassemic individuals who have minimum acceptable Hb level may be accepted as blood donors. This study was aimed at determining the frequency of α-thalassemia 1 trait, β-thalassemia trait, and Hb E-related syndromes in Southern Thai blood donors. One hundred and sixteen voluntary blood donors, Southern Thailand origin, were ...

  10. Individualized Anemia Management Reduces Hemoglobin Variability in Hemodialysis Patients

    Gaweda, Adam E.; Aronoff, George R.; Jacobs, Alfred A.; Rai, Shesh N.; Brier, Michael E.

    2013-01-01

    One-size-fits-all protocol-based approaches to anemia management with erythropoiesis-stimulating agents (ESAs) may result in undesired patterns of hemoglobin variability. In this single-center, double-blind, randomized controlled trial, we tested the hypothesis that individualized dosing of ESA improves hemoglobin variability over a standard population-based approach. We enrolled 62 hemodialysis patients and followed them over a 12-month period. Patients were randomly assigned to receive ESA ...

  11. EPR studies of cooperative binding of Cu (II) to hemoglobin

    Louro, S.R.W.; Tabak, M.

    1983-07-01

    The investigation of the relative affinities of the two pairs of hemoglobin copper sites by monitoring the EPR spectra of the complexes formed by the reaction of copper with deoxyhemoglobin is reported. A model in which two sites are assumed to accept copper ions in a noncooperative way is not able to predict the experimental results. Thus it is conclude that the binding of these ions to hemoglobin is a cooperative phenomenon. (Author) [pt

  12. Comparative study of bedside and laboratory measurements of hemoglobin.

    Krenzischek, D A; Tanseco, F V

    1996-11-01

    The purpose of this study was to examine the effects of variations in technique on measurements of hemoglobin level done at the bedside and to compare these results with laboratory measurements of hemoglobin. In accordance with hospital policy, procedure, and protocol, various techniques were used to obtain samples of capillary and venous blood and of blood from arterial and central venous catheters. Levels of hemoglobin were measured at the bedside and in the laboratory, and the results were compared. The Johns Hopkins Hospital adult postanesthesia care unit. A total of 187 blood samples were obtained from 62 adults who had undergone general surgery. Group I comprised 20 subjects with capillary and venous blood samples. Group II comprised 21 subjects with arterial blood samples. Group III comprised 21 subjects with central venous blood samples. The results showed that the amount of blood to be discarded before obtaining samples of arterial and central venous blood need not be any larger than double the dead space of the catheter, and that shaking the blood sample for 10 seconds was sufficient to mix the sample before measurement of hemoglobin levels. Results of bedside and laboratory measurements of hemoglobin level were comparable. Bedside measurement of hemoglobin increases efficiency in patient care, decreases risk of blood-transmitted infection for staff, and decreases cost to the patient. However, the persons who perform the assay must be responsible in adhering to the standard of practice to minimize errors in the measurements.

  13. Cell volume regulation in hemoglobin CC and AA erythrocytes

    Berkowitz, L.R.; Orringer, E.P.

    1987-01-01

    Swelling hemoglobin CC erythrocytes stimulates a ouabain-insensitive K flux that restores original cell volume. Studies were performed with the K analog, 86 Rb. This volume regulatory pathway was characterized for its anion dependence, sensitivity to loop diuretics, and requirement for Na. The swelling-induced K flux was eliminated if intracellular chloride was replaced by nitrate and both swelling-activated K influx and efflux were partially inhibited by 1 mM furosemide or bumetanide. K influx in swollen hemoglobin CC cells was not diminished when Na in the incubation medium was replaced with choline, indicating Na independence of the swelling-induced flux. Identical experiments with hemoglobin AA cells also demonstrated a swelling-induced increase in K flux, but the magnitude and duration of this increase were considerably less than that seen with hemoglobin CC cells. The increased K flux in hemoglobin AA cells was likewise sensitive to anion replacement and to loop diuretics and did not require the presence of Na. These data indicate that a volume-activated K pathway with similar transport characteristics exists in both hemoglobin CC and AA red cells

  14. New observations on the miniature of the vision of Saint Gregory of Nazianzus in Paris. GR. 510

    Gavrilović Zaga

    2007-01-01

    Full Text Available The article deals with the iconography of the illustration of the Second Paschal Homily of St. Gregory of Nazianzus on fol. 285r of the Paris manuscript. It questions the identity of the woman saint represented on the right of St. Paraskeve in the lower register of the scene. Unlike that above St. Paraskeve, the inscription identifying this second woman saint is fragmentary and difficult to read, but it has been widely accepted that she is Saint Helena, mother of the Emperor Constantine the Great. On the basis of two other representations of Helena in the same manuscript and of the style of the inscription accompanying them, as well as taking into account the importance of the theological meaning expounded by St. Gregory in his oration, it is suggested that the second woman saint may be St. Kyriake.

  15. Center for Transportation Studies 24th annual transportation research conference, May 22-23, 2013, Saint Paul, Minnesota.

    2013-05-01

    The University of Minnesotas Center for Transportation : Studies is pleased to present its 24th Annual Transportation : Research Conference, May 22-23, 2013. The conference will : be held at the Saint Paul RiverCentre, 175 West Kellogg : Boulevard...

  16. Comparison of Hemoglobin Levels Before and After Hemodialysis and Their Effects on Erythropoietin Dosing and Cost

    Sagheb; Fallahzadeh; Moaref; Fallahzadeh; Dormanesh

    2016-01-01

    Background Hemoglobin levels measured after hemodialysis, as compared to hemoglobin levels measured before hemodialysis, are suggested to be a more accurate reflection of the hemoglobin levels between hemodialysis sessions, and to be a better reference point for adjusting erythropoietin dosing. Objectives The aim of this study was to compare the hemoglobin levels before and after hemodialysis, to calculate the required erythropoie...

  17. Impact of bacteriophage Saint3 carriage on the immune evasion capacity and hemolytic potential of Staphylococcus aureus CC398.

    Jung, Philipp; Abdelbary, Mohamed M H; Kraushaar, Britta; Fetsch, Alexandra; Geisel, Jürgen; Herrmann, Mathias; Witte, Wolfgang; Cuny, Christiane; Bischoff, Markus

    2017-02-01

    Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates of clonal complex 398 (CC398) are frequently found in Europe, and recent studies highlighted the importance of mobile genetic element (MGE) exchange for host adaptation of this lineage. Of note, one of the MGEs commonly found in human S. aureus isolates, the immune evasion cluster (IEC) harboring bacteriophage Saint3, is very rarely found in LA-MRSA CC398 isolates obtained from farm animals, but more frequently found in LA-MRSA CC398 that were retransmitted to humans. Here, we analyzed with a set of S. aureus CC398 isolates harboring/lacking φSaint3 how this MGE affects (i) phagocytosis of CC398 isolates by polymorphonuclear neutrophils (PMNs), and (ii) hemolysis of human and livestock-derived erythrocytes. Isolates lacking φSaint3 were more efficiently phagocytosed by human PMNs in whole blood phagocytosis assays than isolates harboring this bacteriophage, irrespective of their origin. Notably, a similar effect was observed when equine blood was utilized, but not detected with porcine blood. Integration of φSaint3 into LA-MRSA CC398 strains lacking this MGE confirmed these findings, as φSaint3-harboring recipients were again less efficiently ingested by PMNs in equine and human blood than their parental strains. Integration of φSaint3 strongly reduced the hemolytic potential of the culture supernatants against human-derived erythrocytes, and to a smaller extent also against porcine-derived erythrocytes, while φSaint3 integration only slightly affected the hemolytic capacities against equine-derived red blood cells. The significant protective effect of φSaint3 against phagocytosis by equine PMNs suggests that the host specificity of the IEC components might be broader than currently assumed. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. El diario de un escritor en Encuentro en Saint-Nazaire de Ricardo Piglia

    Amor Arelis Hernández Peñaloza

    2016-01-01

    Full Text Available En este artículoestudiamos el género diario íntimo a través de la nouvelleEncuentro en Saint-Nazaire(1988 que contiene el ”Diario de un loco”del escritor ficticio Stephen Stevensen. Este uso ficcional del diario, dentro delmarco de la estructura de la obra literaria adquiere un sentido diferente porque renuncia a la comunicación de algo íntimo y secreto, para convertirse en literatura, en ”comunicación estética”. Asimismopretendemosevidenciar la importancia y la magnitud del género diario en la unidad narrativa de un autor como Ricardo Piglia. Junto a esto, el ejemplo de Encuentro en Saint- Nazairenos ayudará a mostrar las características de este tipo de prosa pigliana, que funciona como un laboratorio de la escritura.

  19. Ecole d’été de probabilités de Saint-Flour XXXII

    2004-01-01

    This is yet another indispensable volume for all probabilists and collectors of the Saint-Flour series, and is also of great interest for mathematical physicists. It contains two of the three lecture courses given at the 32nd Probability Summer School in Saint-Flour (July 7-24, 2002). Boris Tsirelson's lectures introduce the notion of nonclassical noise produced by very nonlinear functions of many independent random variables, for instance singular stochastic flows or oriented percolation. Two examples are examined (noise made by a Poisson snake, the Brownian web). A new framework for the scaling limit is proposed, as well as old and new results about noises, stability, and spectral measures. Wendelin Werner's contribution gives a survey of results on conformal invariance, scaling limits and properties of some two-dimensional random curves. It provides a definition and properties of the Schramm-Loewner evolutions, computations (probabilities, critical exponents), the relation with critical exponents of planar...

  20. An annotated checklist of scale insects (Hemiptera: Coccoidea) of Saint Lucia, Lesser Antilles .

    Malumphy, Chris

    2014-07-31

    An annotated list of 83 scale insect species (Hemiptera: Sterorrhyncha: Coccoidea) recorded from Saint Lucia is presented, based on data gathered from UK quarantine interceptions, samples collected in an urban coastal habitat in the North West of the Island in 2013, and published records. Thirty-three species (40%) are recorded for the first time for the country, including Dysmicoccus joannesiae (Costa Lima), a South American mealybug, and Poliaspoides formosana (Takahashi), an Asian armoured scale insect pest of bamboo, which are new for the Caribbean region. The economic, environmental and social impacts caused by introduced exotic species of scale insect are discussed. Two predatory midges Diadiplosis ?coccidivora (Felt) and Diadiplosis multifila (Felt) (Diptera: Cecidomyiidae) are recorded for the first time from Saint Lucia. The latter species was observed causing 90% mortality of a large infestation of passion vine mealybug Planococcus minor (Maskell) on soursop fruit. 

  1. Identification of a haptoglobin-hemoglobin complex in the Alaskan Least Cisco (Coregonus sardinella).

    Wahl, S M; Boger, J K; Michael, V; Duffy, L K

    1992-01-01

    The hemoglobin and a hemoglobin binding protein have been characterized in the Arctic fish (Coregonus sardinella). The evolutionary significance of the hemoglobin and plasma protein differences between fish and mammals is still unresolved. Blood samples from the Alaskan Least Cisco were separated into plasma and hemoglobin fractions and the proteins in these fractions were analyzed both by alkaline agarose gel electrophoresis, by isolelectric focusing, and by capillary electrophoresis. Staining the plasma proteins gels with o-dianisidine revealed hemoglobin containing protein complexes. A hemoglobin-containing band was observed in hemolyzed plasma which did not migrate with free hemoglobin, and is believed to be hemoglobin-haptoglobin complex. Size exclusion chromatography further characterized the hemoglobin as disassociating freely into dimers, and hemoglobin-haptoglobin complex having a molecular weight greater then 200,000 daltons.

  2. A restoration and conservation project of the “Saint Dominic” Monastery in Soriano Calabro, Italy

    Nazzareno Davolos

    2008-04-01

    Full Text Available The article is extracted from the Master Thesis about Restoration of the Monuments at “La Sapienza”, University of the Studies of Rome. The Monastery was one of the most important of the Dominican Order in Europe. The building dates back to year 1510, it broke down almost completely in the earthquake of year 1659. It was rebuilt following the architect B. Presti’s project. At the present time the “Saint Domenic” Monastery largely seems a ruin, mainly as a consequence of the cat- N. Davolos - A restoration and conservation project of the ÒSaint DominicÓ Monastery... 185 astrophic earthquake in 1783. However, with the new look that has acquired, it still preserves an extraordinary charm that continues to astonish. The project followed the trend of the critical and conservative restoration with the safeguard of the artistic and figurative data of the “Saint Domenic” Monastery which has been analysed through an accurate historical-critical work. The idea is to preserve and transmit to the future generations the “Saint Domenic” monument in his authenticity, in its formal and material consistence, with the marks of the passing of time. The abstracts reports only the most important aspects which are representative of the project. Besides the historical analysis, laboratory examination have been executed on the material used in the construction of the ancient facade through the observation of thin sections by optic microscope and with the realization of spectrum of X-ray diffraction, in order to know the nature and composition, the state of preservation and the kinds of deterioration to support an appropriate intervention of restoration.

  3. [The embroidery work of the lady at Saint-Anne Hospital].

    Thillaud, Pierre L; Postel, Jacques

    2014-01-01

    In July 1974, a 72 old woman had been a patient for forty years in Sainte-Anne Hospital, Ward C. As she had again a violent brawl with her neighbour patient, she revealed being a tremendous artist. She had been confined on account of dementia paralytica in the Mecca of malariotherapy, and passionately devoted herself to embroidery. Her fancy work was rather a matter for Jean Dubuffet's art through its perfect expression and deserved being known.

  4. Prayer to the Saints or the Virgin and Health among Older Mexican Americans

    Krause, Neal; Bastida, Elena

    2011-01-01

    The purpose of this study was to evaluate a conceptual model that assesses whether praying to the saints or the Virgin is associated with the health of older Mexican Americans. A survey was conducted of 1,005 older Mexican Americans (Mean age = 73.9 years; SD = 6.6 years). Data from 795 of the Catholic respondents are presented in this study. The…

  5. Ludopathy and the employees at saint bonaventure university, Medellín branch, Colombia, 2010

    Cano Bedoya, Victor Hugo; Universidad de San Buenaventura; Pérez Pérez, Jorge Arturo; Universidad de San Buenaventura, Medellín - Colombia

    2010-01-01

    This current article consists of a description of the use of game of chance and videogames, by the students, instructors, and employees at saint Bonaventure University, Medellin Branch and its relationship with both medical and psychological dimensions, which include variables like the following: concentration difficulties, change of mood, physical discomfort, preference of games to sports, and relaxed atmosphere as it is produced by games. In this true stage, the results with employees are s...

  6. FOOLISHNESS FOR CHRIST, LOVE AND MATERNITY IN LUDMILA ULITSKAYA'S PLAY "THE SEVEN SAINTS"

    Moteyunaite I. V.

    2008-11-01

    Full Text Available The article presents a new understanding of such a complex cultural phenomenon as foolishness for Christ through the example of Ludmila Ulitskaya's historical play "The Seven Saints". The author shows that the hero of the 1990's became a blessed woman (a God's fool, who neither sets an optimistic example nor gives faith in the triumph of spirit, but who can only die with dignity, following Christ's way and His final sacrifice.

  7. Distribution of some organochloride pesticides in the All Saints Bay, Bahia, Brazil

    Beretta, M.; Costa, M.A.; Tavares, T.M.

    1999-01-01

    First restrictions to organochlorine insecticides (OC) in Brazil date of 1976 and by 1985 they were completely prohibited. However use of existing stocks and smuggled parcels as well as official use in malaria campaigns still takes place. During the SH summer of 1995 a cross-sectional survey was conducted for organochloride pesticides in 12 intertidal sites, both in sediments and in some selected edible species of the All Saints Bay, east of Brazil

  8. La théorie de la diplomatie dans le Saint Empire Romain

    Weber, Wolfgang E. J.

    2016-01-01

    Principes Dans ce que l’on nomme officiellement, depuis 1500 environ jusqu’à sa fin en 1806, le Saint Empire romain de la nation allemande (Heiliges Römisches Reich Deutscher Nation), le développement de la théorie de la diplomatie, autrement dit de conceptions relatives aux diplomates et à la diplomatie, est le fait d’élites soucieuses de mieux comprendre des problèmes posé...

  9. The Cerrado of Saint-Hilaire: naturalists representations of a 19th century French traveler

    Lorena Borges Silva

    2016-12-01

    Full Text Available This work aims to investigate the different motivations and goals behind the traveler Saint-Hilarie intentions to invest in a project to enter the Cerrado, and from his narratives and perceptions, we intend to understand how the nature of the Cerrado was interpreted during the nineteenth century. We seek to see why so many derogatory assertions were made by observing the natural surroundings of Goiás.

  10. L’église Saint-Michel de Lille : chronologie d’un chantier

    Catherine Guillot

    2012-04-01

    Full Text Available Après le démantèlement des fortifications de Lille en 1858, un nouveau quartier est aménagé au sud de la ville, dont un des équipements importants est l’église Saint-Michel, construite entre 1868 et 1874 par l’architecte Alfred Coisel. Très bien documenté, son chantier dévoile un mobilier et un décor exemplaire par son homogénéité et par la place accordée à la peinture murale. Cette étude met en évidence, outre le rôle du peintre Alphonse Colas, des artistes méconnus comme Albéric Duyver et Marie Carin. L’iconographie, qui révèle un des plus importants cycles consacrés à l’archange saint Michel, est également extrêmement caractéristique de son temps.After the demolition of the fortifications at Lille, in 1858, a new quarter developed to the south of the city. One of the important features of this new neighbourhood was the Saint-Michel church, built between 1868 and 1874 to the designs of the architect Alfred Coisel. The building of this church is exceptionally well documented and reveals church furnishings and decoration of an exemplary nature in terms of homogeneity and the special place given over to mural paintings. This study underlines the role of the painter Alphonse Colas, but also the contribution of other, less well known artists such as Albéric Duyver and Marie Carin. The iconographical theme is one of the most important cycles of its time devoted to the archangel Saint Michel, and is highly characteristic of the period.

  11. Virological Surveillance of Dengue in Saint Martin and Saint Barthélemy, French West Indies, Using Blood Samples on Filter Paper

    Matheus, Séverine; Chappert, Jean-Loup; Cassadou, Sylvie; Berger, Franck; Labeau, Bhetty; Bremand, Laetitia; Winicki, Alain; Huc-Anais, Patricia; Quenel, Philippe; Dussart, Philippe

    2012-01-01

    To strengthen active dengue surveillance in Saint Martin and Saint Barthélemy, two French Caribbean islands, we evaluated the epidemiological usefulness of collecting blood samples from NS1-positive dengue patients on filter paper to identify the dengue serotypes circulating in these regions during a 27-month period. This approach allowed dengue serotypes to be identified by reverse transcriptase-polymerase chain reaction in 90.1% of the total set of 666 samples analyzed and, in 95.5% of the samples collected during the acute phase of the disease. This prospective virological surveillance using blood samples absorbed onto filter paper, which were stored at 4°C and shipped at ambient temperature to a specialized laboratory for analysis, allowed us to avoid the logistic and financial costs associated with shipping frozen venous blood samples. This surveillance system offers a low-cost alternative for reinforcing dengue prevention in areas where specialized laboratories do not exist, notably by facilitating the early detection of potentially new dengue serotypes. PMID:22232467

  12. The narrow therapeutic window of glycated hemoglobin and assay variability.

    Hosseini, S S; Bibler, I; Charles, M A

    1999-12-01

    Glycated hemoglobin is measured by a variety of assays, each of which has a unique normal level. Our purpose is to show that among the different assays available in the United States, using the same patient's blood sample, assay results may vary widely and may more or less easily achieve a glycated hemoglobin value within the normal range. The following assays were compared using the same patient's blood sample for each pair of assays: glycohemoglobin affinity assay (GHB Reader; Isolab, Akron, OH) versus gel electrophoresis assay (n = 76); Isolab versus ion capture assay (IMX; Abbott Laboratories, Irving, TX) (n = 57); monoclonal antibody assay (DCA2000; Bayer Diagnostics, Pittsburgh, PA) versus IMX (n = 100); and high-performance liquid chromatography (HPLC) assay (Bio-Rad Variant A1c; Bio-Rad Laboratories, Richmond, CA) versus IMX assay (n = 55). Our analyses indicate that a relative ranking can be established for the ease of achieving a normal glycated hemoglobin level. The ranking indicates that the most stringent or difficult assays for achieving a normal level are the Isolab and DCA2000 assays. The intermediate assays are the IMX and Bio-Rad Variant, and the easiest method for achieving a normal value is the gel electrophoresis assay. Our results indicate that various glycated hemoglobin assays vary widely and are associated with more or less difficulty for an individual patient to achieve a glycated hemoglobin level within the normal range. These results are especially significant with respect to (1) the clinically narrow therapeutic window of glycated hemoglobin values in type 1 diabetes to avoid rapidly advancing severe hypoglycemia rates and chronic microvascular complication rates, and (2) the glycated hemoglobin threshold for rapidly advancing macrovascular disease in both type 1 and type 2 patients.

  13. Propanil-induced methemoglobinemia and hemoglobin binding in the rat

    McMillan, D.C.; McRae, T.A.; Hinson, J.A. (National Center for Toxicological Research, Jefferson, AR (USA))

    1990-09-15

    Administration of (ring-U-14C)propanil (3,4-dichloropropionanilide) to male Sprague-Dawley rats (30, 100, and 300 mg/kg, ip) increased the formation of methemoglobin at the two highest doses. Following a propanil dose of 100 mg/kg, methemoglobin formation attained a maximum level of 5% by 1.5 hr and declined to normal levels (approximately 2.5%) by 12 hr. Hemoglobin binding attained a maximum level of 50 pmol/mg protein by 12 hr, and remained constant for 24 hr. Following a propanil dose of 300 mg/kg, methemoglobin formation attained a maximum level of 24% by 4.5 hr, and declined to a level of 5% by 24 hr. Hemoglobin binding attained a maximum level of 425 pmol/mg protein by 12 hr, and remained constant for 24 hr. Hemoglobin binding was also detected at the lowest propanil dose (10 pmol/mg protein) even though methemoglobin formation was not observed. HPLC analysis of alkaline-treated hemoglobin from propanil-treated rats indicated the presence of one radiolabeled compound with the same HPLC retention time as 3,4-dichloraniline. These data are consistent with the concept that propanil is converted to N-hydroxy-3,4-dichloroaniline in the liver. Subsequently, this metabolite enters the erythrocyte and is oxidized by hemoglobin to 3,4-dichloronitrosobenzene with concomitant conversion of oxyhemoglobin to methemoglobin. The 3,4-dichloronitrosobenzene binds to cysteine residues on hemoglobin as the corresponding sulfinic acid amide adduct. These data suggest that human exposure to propanil may be monitored in the absence of observable toxicity by the analysis of propanil metabolites bound to hemoglobin.

  14. Plant hemoglobins: Important players at the crossroads between oxygen and nitric oxide

    Gupta, Kapuganti J; Hebelstrup, Kim; Mur, Luis A J

    2011-01-01

    Plant hemoglobins constitute a diverse group of hemeproteins and evolutionarily belong to three different classes. Class 1 hemoglobins possess an extremely high affinity to oxygen and their main function consists in scavenging of nitric oxide (NO) at very low oxygen levels. Class 2 hemoglobins have...... at high O2 concentrations. Depending on their physical properties, hemoglobins belong either to hexacoordinate non-symbiotic or pentacoordinate symbiotic groups. Plant hemoglobins are plausible targets for improving resistance to multiple stresses....

  15. Selection of aptamers specific for glycated hemoglobin and total hemoglobin using on-chip SELEX.

    Lin, Hsin-I; Wu, Ching-Chu; Yang, Ching-Hsuan; Chang, Ko-Wei; Lee, Gwo-Bin; Shiesh, Shu-Chu

    2015-01-21

    Blood glycated hemoglobin (HbA1c) levels reflecting average glucose concentrations over the past three months are fundamental for the diagnosis, monitoring, and risk assessment of diabetes. It has been hypothesized that aptamers, which are single-stranded DNAs or RNAs that demonstrate high affinity to a large variety of molecules ranging from small drugs, metabolites, or proteins, could be used for the measurement of HbA1c. Aptamers are selected through an in vitro process called systematic evolution of ligands by exponential enrichment (SELEX), and they can be chemically synthesized with high reproducibility at relatively low costs. This study therefore aimed to select HbA1c- and hemoglobin (Hb)-specific single-stranded DNA aptamers using an on-chip SELEX protocol. A microfluidic SELEX chip was developed to continuously and automatically carry out multiple rounds of SELEX to screen specific aptamers for HbA1c and Hb. HbA1c and Hb were first coated onto magnetic beads. Following several rounds of selection and enrichment with a randomized 40-mer DNA library, specific oligonucleotides were selected. The binding specificity and affinity were assessed by competitive and binding assays. Using the developed microfluidic system, the incubation and partitioning times were greatly decreased, and the entire process was shortened dramatically. Both HbA1c- and Hb-specific aptamers selected by the microfluidic system showed high specificity and affinity (dissociation constant, Kd = 7.6 ± 3.0 nM and 7.3 ± 2.2 nM for HbA1c and Hb, respectively). With further refinements in the assay, these aptamers may replace the conventional antibodies for in vitro diagnostics applications in the near future.

  16. [Hemoglobin variants in Colombian patients referred to discard hemoglobinopathies].

    Romero-Sánchez, Consuelo; Gómez Gutiérrez, Alberto; Duarte, Yurani; Amazo, Constanza; Manosalva, Clara; Chila M, Lorena; Casas-Gómez, María Consuelo; Briceño Balcázar, Ignacio

    2015-10-01

    Oxygen transport is altered in hemoglobinopathies. To study the distribution of hemoglobinopathies in Andean subjects without African ancestry. We analyzed blood samples of 1,407 subjects aged 18 to 59 years (58% females), living in the central Andean region of Colombia, referred to discard hemoglobinopathies. The frequency and type of hemoglobinopathy was established by capillary and agarose gel electrophoresis. The frequency of hemoglobinopathies was 34.5% and higher among females. The structural variants found were: AS-heterozygous hemoglobin (8.1%), homozygous SS (3.7%), heterozygous SC (2.2%), AC heterozygotes (0.5%) and heterozygous AE (0.3%). Quantitative variants found were Hb A-Beta thalassemia (13.91%) and Hb H (0.06%), Beta-thalassemia heterozygotes C (0.88%), S-Beta thalassemia heterozygotes (6.07%) and compound heterozygous SC/Beta thalassemia (0.25%), with a persistence of fetal hemoglobin 0. Composite thalassemia was also found in 31%. All techniques showed good correlation and capillary electrophoresis demonstrated a greater detection of hemoglobin variants. The frequency of hemoglobin variants in the analyzed population was high, which is an important public health indicator. The most common hemoglobin variant was HbA/Increased structural Hb A2 and the mos frequent structural hemoglobinopathy was sickle cell trait. Capillary electrophoresis can discern any Hb variants present in the population.

  17. Placental morphology at different maternal hemoglobin levels: a histopathological study

    Kiran, N.; Zubair, A.; Malik, T.M.

    2015-01-01

    To evaluate the histopathological parameters of the placenta like weight, infarct and syncytial knots, at different maternal hemoglobin levels, in both qualitative and quantitative manner. Study design: Descriptive study Place and Duration of Study: Army Medical College, National University of Sciences and Technology in collaboration with Department of Obstetrics and Gynecology, Military Hospital, Rawalpindi, Pakistan, from December 2011 to November 2012. Patients and Methods: A total of 75 placentas were included, that were collected from full term mothers at the time of childbirth. Placental weight was taken without umbilical cord and gross placental infarcts were noted. Samples of placental tissue were taken and stained by haematoxylin and eosin (H and E). Microscopic study was done to evaluate placental infarcts and syncytial knots. Results: Mean placental weight at normal and low maternal hemoglobin was 581.67 ± 83.97g and 482.58 ± 104.74g respectively. Gross placental infarcts were found in all cases having low maternal hemoglobin concentration (60% cases). Syncytial knots were found in all placentas but they were considerably more at decreasing levels of maternal hemoglobin (19.79 ± 5.22). Conclusion: The present study showed decrease in placental weight, increase in placental infarcts and syncytial knot hyperplasia at low maternal hemoglobin concentration, displaying adaptive alterations. (author)

  18. Blood hemoglobin level and treatment outcome of early breast cancer

    Henke, M.; Sindlinger, F.; Ikenberg, H.; Gerds, T.; Schumacher, M.

    2004-01-01

    Background and purpose: to determine whether the blood hemoglobin concentration correlates with the prognosis of patients with early breast cancer and, if so, whether this is restricted to treatment modality. Patients and methods: data were collected retrospectively from patients with early breast cancer (T1,2 NO-2 MO) who underwent either breast-conserving surgery followed by adjuvant radiotherapy (BCS-RT; n = 96) or a modified radical mastectomy (MRM; n = 194). The effect of preoperative blood hemoglobin level, nodal status, histological grading and hormone receptor status on disease-free survival was determined for both treatment modalities using a cox regression model and visualized by kaplan-meier plots. Results: the blood hemoglobin concentration significantly correlated with disease-free survival of patients receiving BCS-RT (relative risk [RR]: 0.67 per g/dl; p = 0.007). This was independent of other known risk factors for breast cancer patients, as determined by multivariate analysis. By contrast, the blood hemoglobin level had no prognostic significance when patients were treated with MRM. Conclusion: blood hemoglobin concentration seems to affect the prognosis of patients with early breast cancer when a treatment schedule that includes radiotherapy is applied. Reduced radiosensitivity due to diminished tumor oxygenation may be the underlying cause. Confirmative trials and studies intended to elucidate the underlying mechanism are warranted. (orig.)

  19. The refractive index of human hemoglobin in the visible range

    Zhernovaya, O; Tuchin, V; Sydoruk, O; Douplik, A

    2011-01-01

    Because the refractive index of hemoglobin in the visible range is sensitive to the hemoglobin concentration, optical investigations of hemoglobin are important for medical diagnostics and treatment. Direct measurements of the refractive index are, however, challenging; few such measurements have previously been reported, especially in a wide wavelength range. We directly measured the refractive index of human deoxygenated and oxygenated hemoglobin for nine wavelengths between 400 and 700 nm for the hemoglobin concentrations up to 140 g l -1 . This paper analyzes the results and suggests a set of model functions to calculate the refractive index depending on the concentration. At all wavelengths, the measured values of the refractive index depended on the concentration linearly. Analyzing the slope of the lines, we determined the specific refraction increments, derived a set of model functions for the refractive index depending on the concentration, and compared our results with those available in the literature. Based on the model functions, we further calculated the refractive index at the physiological concentration within the erythrocytes of 320 g l -1 . The results can be used to calculate the refractive index in the visible range for arbitrary concentrations provided that the refractive indices depend on the concentration linearly.

  20. Biophysical Monitoring and dose response characteristics of irradiated hemoglobin

    Elshemey, W.M; Selim, N.S.; Desouky, O.

    2003-01-01

    The present work aims to move a step forward towards a deeper understanding of the scattering of x-ray, from lyophilized biological samples. Comparative study has been performed using LAXS and UV-visible spectrophotometry for monitoring the dose response characteristics of the hemoglobin molecule of irradiated blood. Blood samples were irradiated at doses ranging from 5 up to 100 Gy. Diluted hemoglobin solution was scanned in the UV- visible range (200-700 nm), and lyophilized hemoglobin was prepared for LAXS measurement. The radiation-induced changes in the hemoglobin structure have been evaluated. The LAXS profile of hemoglobin molecule is characterized by the presence of two peaks in the forward direction of scattering. These peaks were found to be sensitive to the variations in the molecular structure of a given sample. The obtained results suggest that the 1 s t peak, recorded at 4.65 o , is sensitive to the tertiary and quaternary structure of the globin part, while the major peak, recorded at 10.5 o , appeared to be related to its primary and secondary structure

  1. Post-transfusion hemoglobin values and patient blood management

    Moerman, Jan; Vermeulen, Edith; Van Mullem, Mia

    2018-01-01

    Objectives: The objective of this retrospective study was to evaluate the added value of communicating post-transfusion hemoglobin values to clinicians as a strategy to improve RBC utilization in a 500-bed hospital. Methods: The total number of RBC transfusions, the mean number of RBC units...... transfused per patient, the mean pre- and post-transfusion hemoglobin values, the ratio of patients transfused and the ratio of patients with a post-transfusion hemoglobin > 10.5 g/dL were calculated per service and per department for six months. The data were reported to each service and compared...... with the data of the department as peer group. The impact of this communication strategy was evaluated in the following six months. Results: In the six months pre-intervention, the mean post-transfusion hemoglobin value was 9.2 g/dL. Post-transfusion hemoglobin was > 10.5 g/dL in 13.4% of patients (112...

  2. Study of LAXS Profile of Hemoglobin from Irradiated Blood

    Selim, N.S.; Desouky, O.S.; Elshemey, W.M.

    2006-01-01

    The present work aims to move a step forward towards a deeper understanding of the scattering of x-ray, from lyophilized biological samples. Comparative study has been performed using low angle x-ray scattering (LAXS) and UV-visible spectrophotometry for monitoring the dose response characteristics of the hemoglobin molecule of irradiated blood. Blood samples were exposed to gamma rays, at doses ranging from 5 up to 100 Gy. Diluted hemoglobin solution was scanned in the UV-visible range (200-700 nm), and lyophilized hemoglobin was prepared for LAXS measurement. The radiation-induced changes in the hemoglobin structure have been evaluated. The LAXS profile of hemoglobin molecule is characterized by the presence of 2 peaks in the forward direction of scattering. These peaks were found to be sensitive to the variations in the molecular structure of a given sample. The obtained results suggest that the 1st peak, recorded at 4.65O (equivalent to momentum transfer, x= 0.526 nm-1), is sensitive to the tertiary and quaternary structure of the globin part, while the major peak, recorded at 10.5O (equivalent to momentum transfer, x= 1.189 nm-1), appeared to be related to its primary and secondary structure

  3. A microfluidic approach for hemoglobin detection in whole blood

    Taparia, Nikita; Platten, Kimsey C.; Anderson, Kristin B.; Sniadecki, Nathan J.

    2017-10-01

    Diagnosis of anemia relies on the detection of hemoglobin levels in a blood sample. Conventional blood analyzers are not readily available in most low-resource regions where anemia is prevalent, so detection methods that are low-cost and point-of-care are needed. Here, we present a microfluidic approach to measure hemoglobin concentration in a sample of whole blood. Unlike conventional approaches, our microfluidic approach does not require hemolysis. We detect the level of hemoglobin in a blood sample optically by illuminating the blood in a microfluidic channel at a peak wavelength of 540 nm and measuring its absorbance using a CMOS sensor coupled with a lens to magnify the image onto the detector. We compare measurements in microchannels with channel heights of 50 and 115 μm and found the channel with the 50 μm height provided a better range of detection. Since we use whole blood and not lysed blood, we fit our data to an absorption model that includes optical scattering in order to obtain a calibration curve for our system. Based on this calibration curve and data collected, we can measure hemoglobin concentration within 1 g/dL for severe cases of anemia. In addition, we measured optical density for blood flowing at a shear rate of 500 s-1 and observed it did not affect the nonlinear model. With this method, we provide an approach that uses microfluidic detection of hemoglobin levels that can be integrated with other microfluidic approaches for blood analysis.

  4. Development of flood-inundation maps for the Mississippi River in Saint Paul, Minnesota

    Czuba, Christiana R.; Fallon, James D.; Lewis, Corby R.; Cooper, Diane F.

    2014-01-01

    Digital flood-inundation maps for a 6.3-mile reach of the Mississippi River in Saint Paul, Minnesota, were developed through a multi-agency effort by the U.S. Geological Survey in cooperation with the U.S. Army Corps of Engineers and in collaboration with the National Weather Service. The inundation maps, which can be accessed through the U.S. Geological Survey Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ and the National Weather Service Advanced Hydrologic Prediction Service site at http://water.weather.gov/ahps/inundation.php, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the U.S. Geological Survey streamgage at the Mississippi River at Saint Paul (05331000). The National Weather Service forecasted peak-stage information at the streamgage may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the Mississippi River by means of a one-dimensional step-backwater model. The hydraulic model was calibrated using the most recent stage-discharge relation at the Robert Street location (rating curve number 38.0) of the Mississippi River at Saint Paul (streamgage 05331000), as well as an approximate water-surface elevation-discharge relation at the Mississippi River at South Saint Paul (U.S. Army Corps of Engineers streamgage SSPM5). The model also was verified against observed high-water marks from the recent 2011 flood event and the water-surface profile from existing flood insurance studies. The hydraulic model was then used to determine 25 water-surface profiles for flood stages at 1-foot intervals ranging from approximately bankfull stage to greater than the highest recorded stage at streamgage 05331000. The simulated water-surface profiles were then combined with a geographic information system digital elevation model, derived from high-resolution topography

  5. Hemoglobin is essential for normal growth of Arabidopsis organs

    Hebelstrup, Kim Henrik; Hunt, Peter; Dennis, Elizabeth

    2006-01-01

    In Arabidopsis thaliana, the class I hemoglobin AHb1 is transiently expressed in the hydathodes of leaves and in floral buds from young inflorescences. Nitric oxide (NO) accumulates to high levels in these organs when AHb1 is silenced, indicating an important role in metabolizing NO. AHb1-silenced...... lines are viable but show a mutant phenotype affecting the regions where AHb1 is expressed. Arabidopsis lines with an insertional knockout or overexpression of AHb2, a class II 3-on-3 hemoglobin, were generated. Seedlings overexpressing AHb2 show enhanced survival of hypoxic stress. The AHb2 knockout...... lines develop normally. However, when AHb2 knockout is combined with AHb1 silencing, seedlings die at an early vegetative stage suggesting that the two 3-on-3 hemoglobins, AHb1 and AHb2, together play an essential role for normal development of Arabidopsis seedlings. In conclusion, these results...

  6. An Atomistic View on Human Hemoglobin Carbon Monoxide Migration Processes

    Lucas, M. Fátima; Guallar, Víctor

    2012-01-01

    A significant amount of work has been devoted to obtaining a detailed atomistic knowledge of the human hemoglobin mechanism. Despite this impressive research, to date, the ligand diffusion processes remain unclear and controversial. Using recently developed computational techniques, PELE, we are capable of addressing the ligand migration processes. First, the methodology was tested on myoglobin's CO migration, and the results were compared with the wealth of theoretical and experimental studies. Then, we explored both hemoglobin tense and relaxed states and identified the differences between the α-and β-subunits. Our results indicate that the proximal site, equivalent to the Xe1 cavity in myoglobin, is never visited. Furthermore, strategically positioned residues alter the diffusion processes within hemoglobin's subunits and suggest that multiple pathways exist, especially diversified in the α-globins. A significant dependency of the ligand dynamics on the tertiary structure is also observed. PMID:22385860

  7. Síntese e caracterização de um novo composto obtido pela reação entre hidreto de trifenilestanho e ácido (±)-mandélico e avaliação de seu potencial biocida sobre o fungo Fusarium oxysporum f. sp. cubense

    Barbiéri, Roberto Santos; Lima, Elysio Prado de; Silva, Samuel Ferreira da; Dias, Allan Kardec Carlos; Cardoso, Maria das Graças; Terra, Vilma Reis

    2006-01-01

    O presente artigo refere-se à síntese e caracterização de um novo composto organoestânico, pela reação de ácido (±)-mandélico e hidreto de trifenilestanho, em meio de acetonitrila e sob refluxo, [(C6H5)2SnMand 2] {Mand = C6H5CH(OH)COO], identificado por análise elementar de carbono e hidrogênio, espectroscopia no infravermelho e espectrometria de massa de alta resolução, para o qual foi proposta estrutura octaédrica com o grupo fenila em posição trans. Verificou-se que o composto apresenta aç...

  8. Nitric Oxide in Plants: The Roles of Ascorbate and Hemoglobin

    Wang, Xiaoguang; Hargrove, Mark S.

    2013-01-01

    Ascorbic acid and hemoglobins have been linked to nitric oxide metabolism in plants. It has been hypothesized that ascorbic acid directly reduces plant hemoglobin in support of NO scavenging, producing nitrate and monodehydroascorbate. In this scenario, monodehydroascorbate reductase uses NADH to reduce monodehydroascorbate back to ascorbate to sustain the cycle. To test this hypothesis, rates of rice nonsymbiotic hemoglobin reduction by ascorbate were measured directly, in the presence and absence of purified rice monodehydroascorbate reductase and NADH. Solution NO scavenging was also measured methodically in the presence and absence of rice nonsymbiotic hemoglobin and monodehydroascorbate reductase, under hypoxic and normoxic conditions, in an effort to gauge the likelihood of these proteins affecting NO metabolism in plant tissues. Our results indicate that ascorbic acid slowly reduces rice nonsymbiotic hemoglobin at a rate identical to myoglobin reduction. The product of the reaction is monodehydroascorbate, which can be efficiently reduced back to ascorbate in the presence of monodehydroascorbate reductase and NADH. However, our NO scavenging results suggest that the direct reduction of plant hemoglobin by ascorbic acid is unlikely to serve as a significant factor in NO metabolism, even in the presence of monodehydroascorbate reductase. Finally, the possibility that the direct reaction of nitrite/nitrous acid and ascorbic acid produces NO was measured at various pH values mimicking hypoxic plant cells. Our results suggest that this reaction is a likely source of NO as the plant cell pH drops below 7, and as nitrite concentrations rise to mM levels during hypoxia. PMID:24376554

  9. Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

    Yang, S.Y. [MagQu Co. Ltd., Sindian City, Taipei County 231, Taiwan (China); Institute of Electro-optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (China); Lan, C.B.; Chen, C.H. [Institute of Electro-optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (China); Horng, H.E. [Institute of Electro-optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (China)], E-mail: phyfv001@scc.ntnu.edu.tw; Hong, Chin-Yih [Department of Mechanical Engineering, Nan-Kai University of Technology, Nantau County, Taiwan (China)], E-mail: cyhong@nkut.edu.tw; Yang, H.C. [Department of Physics, National Taiwan University, Taipei 106, Taiwan (China)], E-mail: hcyang@phys.ntu.edu.tw; Lai, Y.K. [College of Life Sciences, National Tsing Hua University, Hsinchu City 300, Taiwan (China); Department of Bioresources, Da-Yeh University, Changhua 515, Taiwan (China); Lin, Y.H.; Teng, K.S. [Apex Biotechnology Co. Ltd., Hsinchu City 300, Taiwan (China)

    2009-10-15

    Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

  10. Dichloromethane as an antisickling agent in sickle cell hemoglobin

    Schoenborn, B.P.; North, B.E.

    1977-01-01

    Observations are reported that show that dichloromethane (DCM) does have a significant effect on the oxygen binding properties of hemoglobin. At DCM pressures high enough to prevent or reverse sickling, DCM would lower the oxygen affinity of hemoglobin, therefore reducing oxygen transport at low oxygen pressure. This decrease in oxygen affinity might, however, increase the oxygen availability to tissue as long as a sufficiently large lung P/sub O/sub 2// is maintained. Crystallographic studies show that site D4 has a much lower affinity for DCM than site D3 while sites D1 and D2 show a higher affinity.

  11. Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

    Yang, S.Y.; Lan, C.B.; Chen, C.H.; Horng, H.E.; Hong, Chin-Yih; Yang, H.C.; Lai, Y.K.; Lin, Y.H.; Teng, K.S.

    2009-01-01

    Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

  12. Why are there two kinds of chain in tetrameric hemoglobins

    Ferreira, R.; Jacchieri, S.G.

    1981-01-01

    The homeotropic allosteric interactions responsible for the sigmoidal oxygen saturation curves of α 2 β 2 hemoglobins are shown to be larger than those of hypothetical hemoglobins obeying identical curves and built from equivalent chains, γ 4 . It is also shown that this ensures for the α 2 β 2 species a more dependable cooperativity, through a biologically significative temperature range. On the basis of these findings it is argued that the existence of two different globin chains is advantageous in an evolutionary sense. (Author) [pt

  13. Postoperative hemoglobin level in patients with femoral neck fracture

    Nagra, Navraj; van Popta, Dmitri; Whiteside, Sigrid; Holt, Edward

    2018-01-01

    Objective: The aim of this study was to analyze the changes of hemoglobin levels in patients undergoing fixation for femoral neck fracture.Methods: Peroperative hemoglobin levels of patients who underwent either dynamic hip screw (DHS) fixation (n=74; mean age: 80 years) or hip hemiarthroplasty (n=104; mean age: 84 years) for femoral neck fracture was monitored.Results: There was a statistically and clinically significant mean drop of 31.1 g/L between the preoperative (D0) and postoperative D...

  14. Respiratory properties of blood and hemoglobin solutions from the piranha

    Wood, S.C.; Weber, Roy E.; Powers, D.

    1979-01-01

    1. Respiratory properties of piranha blood are distinguished from those of other fish primarily by the high CO2 buffering capacity (?HCO3/-?pH= 19.6mmol/l for oxygenated blood and 39.1 mmol/l for deoxygenated blood). 2. The concentration of nucleoside triphosphates (NTP) and the half-saturation t......) lowered the oxygen affinity of purified hemoglobin solutions, accounting for the size-dependent correlation ofP50 and NTP concentration in whole blood. 5. While similar in concentration in red cells, GTP is more potent than ATP as an allosteric modifier of hemoglobin function....

  15. Is Routine Ordering of Both Hemoglobin and Hematocrit Justifiable?

    Addison, David J.

    1966-01-01

    In order to assess the value of routine simultaneous hemoglobin and hematocrit determinations, paired determinations in the following groups were studied: (1) 360 consecutive pairs from the hematology laboratory, (2) 95 pairs on general medical patients, (3) 43 pairs on 10 patients with upper gastrointestinal hemorrhage, and (4) 62 pairs on 10 patients with burns. These values were plotted on scatter diagrams. In the 560 pairs only three disparate determinations were found. It is concluded that, in most clinical situations, determination of the hemoglobin or the hematocrit as a screening procedure provides as much useful information as the simultaneous determination of both. PMID:5296947

  16. Uso da barra transpalatina no controle da rotação da mandíbula The transpalatal bar used for the mandibular rotation control

    Jurandir A. Barbosa

    2005-10-01

    Full Text Available Na maioria dos pacientes na fase de dentição mista, com um certo grau de mordida aberta acompanhado de deglutição atípica ou algum mau hábito, observamos que o processo dentoalveolar superior está aumentado no sentido vertical. O uso da BTP nos molares superiores nestes casos, com a alça central colocada numa altura suficiente para, durante a deglutição, exercer alguma pressão sobre o dorso da língua, tem se mostrado de grande valia, notando-se como resultado uma restrição do crescimento do processo dentoalveolar no sentido vertical. Este resultado evita o deslocamento dentário no sentido vertical podendo até provocar movimento efetivo de intrusão dos molares com conseqüente mudança do eixo de crescimento com rotação da mandíbula no sentido anti-horário.Most of pacients in mixed dentition, with some open bite degree and atypical deglutition, we notice that the upper dentoalveolar process is increasing to the vertical side. The BTP use on the upper molar in these situations, with the central arch, low enough to make some pressure on the tongue during the deglutition. This system has been aproved as a molar intrusion movement. Can be noticed as a result the restriction of dentoalveolar process grown to the vertical side, orthopedic and jaw axes rotation grown in the horizontal direction changings.

  17. Sexual dimorphism in the mandible of the armadillo Chaetophractus villosus (Desmarest, 1804 (Dasypodidae from northern Patagonia, Argentina Dimorfismo sexual da mandíbula do tatu Chaetophractus villosus (Desmarest, 1804 (Dasypodidae do norte da Patagônia Argentina

    SM. Squarcia

    2009-05-01

    Full Text Available The aim of this study was to study the sexual dimorphism in adult Chaetophractus villosus (Desmarest, 1804, from northern Patagonia, Argentina. Eight mandibular traits were measured in 37 males and 34 females. Univariate and multivariate morphometric analysis were applied to the data set. Results showed that C. villosus was sexually dimorphic, with higher absolute values corresponding to females. The total length of the mandible was the most important variable to discriminate sexes, followed by the height at the level of the last tooth and body length. The percentages of sex discrimination were high, as they were when a new sample (17 males, 13 females was tested. Females have larger mandibles than males independently of their larger cranial size. They also showed a higher degree of correlation between variables, suggesting a more stable shape for the mandible than in males.O presente estudo examinou o dimorfismo sexual dos adultos de Chaetophractus villosus (Desmarest, 1804 do norte da Patagônia Argentina. Oito parâmetros mandibulares foram medidos em 37 machos e 34 fêmeas. Análises morfométricas univariada e multivariada foram aplicadas à série de dados. Os resultados mostraram que C. villosus apresenta dimorfismo sexual, com todos os valores absolutos mais elevados nas fêmeas. O comprimento total da mandíbula foi a variável mais importante para discriminar os sexos, seguidos pela altura no nível dos últimos dentes e pelo comprimento do corpo da mandíbula. As porcentagens de discriminação dos sexos foram elevadas, quando uma amostra nova (17 machos, 13 fêmeas foi testada. As fêmeas têm as mandíbulas maiores que os machos, independentemente de seu tamanho cranial maior. Mostraram também um grau mais elevado de correlação entre variáveis, sugerindo uma forma mais estável para a mandíbula que nos machos.

  18. The Way of Saint James and the Xacobeo 2010 in the tourism websites of the Spanish autonomous communities

    María-Dolores Fernández-Poyatos, Ph.D.

    2012-01-01

    Full Text Available This article analyses the tourism websites of Spanish autonomous communities crossed by the Way of Saint James. Considering that the Way of Saint James and the Xacobeo 2010 are important touristic opportunities for these autonomous regions, the main objective of this investigation is to evaluate the information about these touristic places in their tourism websites. The analysis focused on two aspects: firstly, establishing whether the autonomous communities have used the Way of Saint James and the Xacobeo 2010 to promote themselves, and secondly, evaluating the quality of the websites. The study included a literature review, definition of concepts and criteria to measure the quality of websites, and the analysis of the content and design of the selected tourism websites. The results show that the Galician website is the most complete in terms of information about the Way of Saint James and the Xacobeo 2010. The information about the Way of Saint James and the Xacobeo 2010 in the websites of the other communities is vague and differs from one website to another. Due to the touristic significance of the Xacobeo 2010 and the importance of Internet as a medium of communication, the research group plans to conduct a new analysis of the communities’ institutional websites in 2011.

  19. La collégiale Saint-Étienne de Neuvy-Saint-Sépulchre (Indre The collegiate church of Saint-Étienne at Neuvy-Saint-Sépulchre (Indre, France. A recent building survey of the rotunda and the nave

    Simon Bryant

    2006-05-01

    Full Text Available La collégiale Saint-Étienne à Neuvy-Saint-Sépulchre (Indre est un des rares édifices subsistants en France qui soit conçu comme une copie de l’église du Saint-Sépulcre de Jérusalem. L’étude archéologique, réalisée pendant des travaux, a permis de préciser les étapes de son évolution depuis sa fondation dans les années 1040. La rotonde, avec ses onze piliers centraux, a été ajoutée à l’extrémité ouest d’une église antérieure. Le mur extérieur a été achevé dans cette première phase mais la cage centrale, qui abritait l’édicule, n’a été terminée qu’au début du XIIe s. Pendant la deuxième moitié du XIIe s., l’église est profondément remaniée et sans doute raccourcie avec la création d’un chevet plat. La voûte primitive est remplacée par trois travées de croisées d’ogives. L’édifice sert de refuge pendant la guerre de Cent Ans, ce qui provoque certains dégâts, partiellement réparés. Malgré les ruptures évidentes dans la construction et un plan irrégulier, l’étude montre que l’édifice est le résultat de la poursuite d’un projet architectural cohérent et original visant à évoquer l’église du Saint-Sépulcre de Jérusalem.The collegiate church of Saint-Étienne at Neuvy-Saint-Sépulchre (Department of the Indre, France is one of the few surviving rotundas built as a copy of the Holy-Sepulcre of Jerusalem during the mid 11th century. Many theories have been advanced concerning the history and the dating of this unusual monument. A recent building survey, carried out during restoration work, has managed to clarify the main phases of its evolution. The rotunda, with eleven central pillars placed around the reliquary monument, was added onto the west end of an existing church during the 1040’s. The two upper stories of the central cage, however, were not finished until the early 12th century. During the second half of the 12th century, the church was extensively

  20. IAEA Operational Safety Team Reviews Saint-Alban Nuclear Power Plant, France

    2010-01-01

    Full text: An international team of nuclear installation safety experts, led by the International Atomic Energy Agency (IAEA), has reviewed safety practices at France's Saint-Alban Nuclear Power Plant (NPP) and has highlighted a set of strong practices as well as a series of recommendations to reinforce them. The IAEA assembled the team at the request of the Government of France to conduct an Operational Safety Review (OSART) of the Saint-Alban NPP. Under the leadership of the IAEA's Division of Nuclear Installation Safety in Vienna, the OSART team performed an in-depth operational safety review from 20 September to 6 October 2010. The team was made up of experts from Belgium, Canada, the Czech Republic, Germany, Lithuania, the Netherlands, Slovakia, Sweden and the USA. An OSART mission is designed to review programmes and activities essential to operational safety. It is not a regulatory inspection, nor is it a design review or a substitute for an exhaustive assessment of the plant's overall safety status. The team at Saint-Alban conducted an in-depth review of the aspects essential to the safe operation of the NPP, which largely are under the control of the site management. The conclusions of the review are based on the IAEA's Safety Standards and proven good international practices. The review covered the areas of Management, Organization and Administration; Training and Qualification; Operations; Maintenance; Technical Support; Operating Experience; Radiation Protection; Chemistry; and Emergency Planning and Preparedness. The OSART team has identified good plant practices, which will be shared with the rest of the nuclear industry for consideration of their application. Examples include: A safety guideline for outages; The use of remote video surveillance of fuel inspection and handling activities; A motivational tool for plant staff regarding the benefits of operating experience and associated corrective actions; and Use of a sophisticated key control system

  1. Consistent initial conditions for the Saint-Venant equations in river network modeling

    C.-W. Yu

    2017-09-01

    Full Text Available Initial conditions for flows and depths (cross-sectional areas throughout a river network are required for any time-marching (unsteady solution of the one-dimensional (1-D hydrodynamic Saint-Venant equations. For a river network modeled with several Strahler orders of tributaries, comprehensive and consistent synoptic data are typically lacking and synthetic starting conditions are needed. Because of underlying nonlinearity, poorly defined or inconsistent initial conditions can lead to convergence problems and long spin-up times in an unsteady solver. Two new approaches are defined and demonstrated herein for computing flows and cross-sectional areas (or depths. These methods can produce an initial condition data set that is consistent with modeled landscape runoff and river geometry boundary conditions at the initial time. These new methods are (1 the pseudo time-marching method (PTM that iterates toward a steady-state initial condition using an unsteady Saint-Venant solver and (2 the steady-solution method (SSM that makes use of graph theory for initial flow rates and solution of a steady-state 1-D momentum equation for the channel cross-sectional areas. The PTM is shown to be adequate for short river reaches but is significantly slower and has occasional non-convergent behavior for large river networks. The SSM approach is shown to provide a rapid solution of consistent initial conditions for both small and large networks, albeit with the requirement that additional code must be written rather than applying an existing unsteady Saint-Venant solver.

  2. On the Life and Deeds of San Precario, Patron Saint of Precarious Workers and Lives

    Marcello Tarì

    2005-01-01

    Full Text Available Noi siamo la generazione post-socialista, la generazione del dopo guerra fredda, della fine delle burocrazie verticali e del controllo sull'informazione. Siamo un movimento globale e neuropeo, che porta avanti la rivoluzione democratica scaturita dal Sessantotto mondiale e lotta contro la distopia neoliberista oggi al culmine. Siamo ecoattivisti e mediattivisti, siamo i libertari della Rete e i metroradicali dello spazio urbano, siamo le mutazioni transgender del femminismo globale, siamo gli hacker del terribile reale. Siamo gli agitatori del precariato e gli insorti del cognitariato. Siamo anarcosindacalisti e postsocialisti. Siamo tutti migranti alla ricerca di una vita migliore. E non ci iconosciamo in voi, stratificazioni tetre e tetragone di ceti politici sconfitti già nel XX secolo. Non ci riconosciamo nella sinistra italyana.Manifesto Bio/Pop del Precariato Metroradicale, 20042004 has marked the beginning of the spreading "cult" of San Precario, Patron Saint of precarious, casual, sessional, temporary, flexible and fractional workers. The Saint appears in public spaces in occasion of rallies, marches, interventions and demonstrations, and its popularity has lead to development of a precise and colorful iconography, hagiography and rituals. This popularity conversely is also the sign of the gravity of the issue of precarity in Italy and Europe .San Precario epitomises current Italian activist practices. These practices, although specifically Italian, intersect with similar realities in Europe and are based on mythopoetic narratives and actions and mediatic embodiments. This paper analysis a variety of texts produced around San Precario, from posters, saint cards, product cards, videos, "official" narratives, personal accounts, relating them to the political debate surrounding precarity.

  3. Training needs assessment of health care professionals in a developing country: the example of Saint Lucia.

    Gaspard, Janice; Yang, Che-Ming

    2016-04-16

    Continuing education (CE) is crucial for quality improvement in health care. The needs assessment of CE helps ensure effectiveness. However, such an assessment necessitates certain techniques that are unfamiliar to health care communities in developing countries. This study identifies the needs of providing CE to health care personnel in Saint Lucia. This study was designed as a questionnaire survey to investigate the demographics, training needs, and preferred approaches to improve performance of the target population. The study population included the health care professionals of major public health care facilities in Saint Lucia. We used the World Health Organization-adopted Hennessy Hicks Training Needs Analysis Questionnaire, a self-reported close-ended structured questionnaire with a core set of 30 items. These items refer to tasks that are central to the role of health care professionals and are categorized into six superordinate categories: research/audit, communication/teamwork, clinical skills, administrative, managerial/supervisory, and continuing professional education. In total, 208 questionnaires were distributed; the response rate was 66.8%, and most respondents were nurses. The need for continuing professional education was rated the highest priority, followed by research/audit activities. The evidence suggests that most respondents required training in communication skills, management, clinical skills, and research methods. Providing training according to the needs is vital, particularly in developing countries. The present research methodology and findings offer perspectives on how to conduct needs assessment and offer reference points for developing countries whose background and health care environment are similar to those of Saint Lucia.

  4. The effect of ionizing radiation on hemoglobin synthesis

    Lipinski, S

    1972-01-01

    The effect of ionizing radiation on hemoglobin synthesis was studied and its effect on the quality of protein was discovered. The biological effects due to the changes in the structure of protein were also observed. The results of the experiments are presented.

  5. Recombinant bacterial hemoglobin alters metabolism of Aspergillus niger

    Hofmann, Gerald; Diano, Audrey; Nielsen, Jens

    2009-01-01

    , the fungus will produce various by-products like organic acids and polyols. In order to circumvent this problem we here study the effects of the expression of a bacterial hemoglobin protein on the metabolism of A. niger. We integrated the vgb gene from Vitreoscilla sp. into the genome at the pyrA locus...

  6. Relationship of Hemoglobin to Arterial Oxygen Desaturation during Aeromedical Evacuation

    2015-04-02

    2. REPORT TYPE Special Report 3. DATES COVERED (From – To) September 2012 – September 2014 4. TITLE AND SUBTITLE Relationship of Hemoglobin to...pressurized pulsatile, and hydrosurgery debridement methods for removing bacteria from fracture implants. Orthopedics. 2012; 35(7):e1046-e1050. 11. Burns TC

  7. Hemoglobin is essential for normal growth of Arabidopsis organs

    Hebelstrup, Kim Henrik; Hunt, Peter; Dennis, Elizabeth

    2006-01-01

    In Arabidopsis thaliana, the class I hemoglobin AHb1 is transiently expressed in the hydathodes of leaves and in floral buds from young inflorescences. Nitric oxide (NO) accumulates to high levels in these organs when AHb1 is silenced, indicating an important role in metabolizing NO. AHb1-silence...... suggests that 3-on-3 hemoglobins apart from a role in hypoxic stress play a general role under non-stressed conditions where they are essential for normal development by controlling the level of NO which tends to accumulate in floral buds and leaf hydathodes of plants......In Arabidopsis thaliana, the class I hemoglobin AHb1 is transiently expressed in the hydathodes of leaves and in floral buds from young inflorescences. Nitric oxide (NO) accumulates to high levels in these organs when AHb1 is silenced, indicating an important role in metabolizing NO. AHb1-silenced...... lines are viable but show a mutant phenotype affecting the regions where AHb1 is expressed. Arabidopsis lines with an insertional knockout or overexpression of AHb2, a class II 3-on-3 hemoglobin, were generated. Seedlings overexpressing AHb2 show enhanced survival of hypoxic stress. The AHb2 knockout...

  8. Effect of some high consumption spices on hemoglobin glycation.

    Naderi, G H; Dinani, Narges J; Asgary, S; Taher, M; Nikkhoo, N; Boshtam, M

    2014-01-01

    Formation of glycation products is major factor responsible in complications of diabetes. Worldwide trend is toward the use of natural additives in reducing the complications of diseases. Therefore, there is a growing interest in natural antiglycation found in plants. Herbs and spices are one of the most important targets to search for natural antiglycation from the point of view of safety. This study investigated the ability of some of the spices to inhibit glycation process in a hemoglobin/glucose model system and compared their potency with each other. For this subject the best concentration and time to incubate glucose with hemoglobin was investigated. Then the glycosylation degree of hemoglobin in the presence of extracts by the three concentrations 0.25, 0.5 and 1 μg/ml was measured colorimetrically at 520 nm. Results represent that some of extracts such as wild caraway, turmeric, cardamom and black pepper have inhibitory effects on hemoglobin glycation. But some of the extracts such as anise and saffron have not only inhibitory effects but also aggravated this event and have proglycation properties. In accordance with the results obtained we can conclude that wild caraway, turmeric, cardamom and black pepper especially wild caraway extracts are potent antiglycation agents, which can be of great value in the preventive glycation-associated complications in diabetes.

  9. Site-specific semisynthetic variant of human hemoglobin

    Hefta, S.A.; Lyle, S.B.; Busch, M.R.; Harris, D.E.; Matthew, J.B.; Gurd, F.R.N.

    1988-01-01

    A single round of Edman degradation was employed to remove the NH 2 -terminal valine from isolated α chains of human hemoglobin. Reconstitution of normal β chains with truncated or substituted α chains was used to form truncated (des-Val 1 -α1) and substituted ([[1- 13 C]Gly 1 ]α1) tetrameric hemoglobin analogs. Structural homology of the analogs with untreated native hemoglobin was established by using several spectroscopic and physical methods. Functional studies indicate that the reconstituted tetrameric protein containing des-Val 1 -α chains has a higher affinity for oxygen, is less influenced by chloride ions or 2,3-biphosphoglycerate, and shows lower cooperativity than native hemoglobin. These results confirm the key functional role of the α-chain NH 2 terminus in mediating cooperative oxygen binding across the dimer interface. The NH 2 -terminal pK/sub 1/2/ value was determined for the [ 13 C]glycine-substituted analog to be 7.46 +/- 0.09 at 15 0 C in the carbon monoxide-liganded form. This value, measured directly by 13 C NMR, agrees with the determination made by the less-direct 13 CO 2 method and confirms the role of this residue as a contributor to the alkaline Bohr effect; however, it is consistent with the presence of an NH 2 -terminal salt bridge to the carboxylate of Arg-141 of the α chain in the liganded form

  10. A Review on hematology and hemoglobin of fish

    Ebru YILMAZ

    2015-01-01

    Full Text Available Determination of hematological parameters of fish living in natüre helps to recognize population and to determinate of pollutants in the aquatic environment. In this review, hematological parameters of fish, fish hemoglobin and the Bohr effect were given information.

  11. Influence of hemoglobin on non-invasive optical bilirubin sensing

    Jiang, Jingying; Gong, Qiliang; Zou, Da; Xu, Kexin

    2012-03-01

    Since the abnormal metabolism of bilirubin could lead to diseases in the human body, especially the jaundice which is harmful to neonates. Traditional invasive measurements are difficult to be accepted by people because of pain and infection. Therefore, the real-time and non-invasive measurement of bilirubin is of great significance. However, the accuracy of currently transcutaneous bilirubinometry(TcB) is generally not high enough, and affected by many factors in the human skin, mostly by hemoglobin. In this talk, absorption spectra of hemoglobin and bilirubin have been collected and analyzed, then the Partial Least Squares (PLS) models have been built. By analyzing and comparing the Correlation and Root Mean Square Error of Prediction(RMSEP), the results show that the Correlation of bilirubin solution model is larger than that of the mixture solution added with hemoglobin, and its RMSEP value is smaller than that of mixture solution. Therefore, hemoglobin has influences on the non-invasive optical bilirubin sensing. In next step, it is necessary to investigate how to eliminate the influence.

  12. Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease

    Di Angelantonio, Emanuele; Gao, Pei; Khan, Hassan

    2014-01-01

    IMPORTANCE: The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain. OBJECTIVE: To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of c...

  13. 21 CFR 864.7470 - Glycosylated hemoglobin assay.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Glycosylated hemoglobin assay. 864.7470 Section 864.7470 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages § 864.7470...

  14. 21 CFR 864.7415 - Abnormal hemoglobin assay.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Abnormal hemoglobin assay. 864.7415 Section 864.7415 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages § 864.7415 Abnormal...

  15. 21 CFR 864.5620 - Automated hemoglobin system.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Automated hemoglobin system. 864.5620 Section 864.5620 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Automated and Semi-Automated Hematology Devices § 864...

  16. 21 CFR 864.7500 - Whole blood hemoglobin assays.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Whole blood hemoglobin assays. 864.7500 Section 864.7500 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages § 864.7500 Whole...

  17. 21 CFR 864.7440 - Electrophoretic hemoglobin analysis system.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Electrophoretic hemoglobin analysis system. 864.7440 Section 864.7440 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages § 864...

  18. The influence of socioeconomic status on the hemoglobin level and ...

    Materials and Methods: This is a cross-sectional study involving 100 children with SCA and 100 age-, sex-, and social class-matched controls that fulfilled the inclusion criteria. Social class was assessed using educational attainment and occupation of parents. Hemoglobin concentration was determined using the ...

  19. A Microplate Assay for the Determination of Hemoglobin Concentration

    Frenchik, Michael D; McFaul, Steve J; Tsonev, Latchezar I

    2004-01-01

    ... (NaOH), and converts all hemoglobin species, including COHb, to AHD within 5 min. Both protocols are carried out in cuvettes, and are, therefore, time intensive and difficult to manage when many samples are quantified. This impedes acquisition of triplicate values for each sample necessary to improve accuracy and determine statistical significance.

  20. Expression and purification of recombinant hemoglobin in Escherichia coli

    Natarajan, Chandrasekhar; Jiang, Xiaoben; Fago, Angela

    2011-01-01

    BACKGROUND: Recombinant DNA technologies have played a pivotal role in the elucidation of structure-function relationships in hemoglobin (Hb) and other globin proteins. Here we describe the development of a plasmid expression system to synthesize recombinant Hbs in Escherichia coli, and we describe...

  1. Importance of hemoglobin concentration to exercise: acute manipulations

    Calbet, José A L; Lundby, Carsten; Koskolou, Maria

    2006-01-01

    An acute reduction of blood hemoglobin concentration ([Hb]), even when the circulating blood volume is maintained, results in lower (.)V(O(2)(max) and endurance performance, due to the reduction of the oxygen carrying capacity of blood. Conversely, an increase of [Hb] is associated with enhanced...

  2. Myth or reality : Hematocrit and hemoglobin differ in trauma

    Nijboer, Johanna M. M.; van der Horst, Iwan C. C.; Hendriks, Herman G. D.; ten Duis, Hendrik-Jan; Nijsten, Maarten W. N.

    Background: Estimating blood loss in trauma patients usually involves the determination of hematocrit (Ht) or hemoglobin (Hb). However, in trauma patients, a poorly substantiated habit exists to determine both Ht and Hb in assessing acute blood loss. This suggests that Ht and Hb provide different

  3. Nonenzymatic glycosylation of human hemoglobin at multiple sites

    Shapiro, R.; McManus, M.; Garrick, L.; McDonald, M.J.; Bunn, H.F.

    1979-01-01

    The most abundant minor hemoglobin component of human hemolysate is Hb A1c, which has glucose bound to the N-terminus of the beta chain by a ketoamine linkage. Hb A1c is formed slowly and continuously throughout the 120 day lifespan of the red cell. It can be synthesized in vitro by incubating purified hemoglobin with 14C-glucose. Other minor components, Hb A1a1 and Hb A1a2 are adducts of sugar phosphates at the N-terminus of the beta chain. Hb A1b contains an unidentified nonphosphorylated sugar at the beta N-terminus. In addition, a significant portion of the major hemoglobin component (Hb Ao) is also glycosylated by a glucose ketoamine linkage at other sites on the molecule, including the N-terminus of the alpha chain and the epsilon-amino group of several lysine residues on both the alpha and the beta chains. The results indicate that the interaction of glucose and hemoglobin is rather nonspecific and suggests that other proteins are modified in a similar fashion

  4. Prediction models for hemoglobin deferral in whole blood donors

    Baart, A.M.

    2013-01-01

    Each year, a relevant proportion of the invited blood donors is eventually deferred from donation because of low hemoglobin (Hb) levels. Deferrals are meant to protect donors from developing iron deficiency anemia after a blood donation, however, they may increase the risk of donor lapse, even

  5. Direct electrochemistry of hemoglobin entrapped in dextran film on ...

    Direct electrochemistry of hemoglobin (Hb) entrapped in the dextran (De) film on the surface of a room temperature ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF6) modified carbon paste electrode (CILE) has been investigated. UV-Vis and FT-IR spectroscopy showed that Hb retained its native ...

  6. Relationships between hemoglobin A1c and spot glucose ...

    Background: Glycosylated hemoglobin, HbA1c is the most acceptable measure of chronic glycemia. It is not widely available and/or affordable in Nigeria. The mean of the monthly fasting plasma glucose (MFPG) of the preceding 3 months is often used as surrogate for assessing chronic glycemia. Objective: To determine the ...

  7. Routine hemoglobin electrophoresis for pediatric surgery day case ...

    Background: Hemoglobin electrophoresis (HBE) is a part of the preoperative routine requested by anesthetists. However, the prevalence of hemoglobinopathy in the population is low. This study aims to determine the clinical risk factors for hemoglobinopathies and propose clinical guidelines for preoperative screening of ...

  8. Hemoglobin, Growth, and Attention of Infants in Southern Ethiopia

    Aubuchon-Endsley, Nicki L.; Grant, Stephanie L.; Berhanu, Getenesh; Thomas, David G.; Schrader, Sarah E.; Eldridge, Devon; Kennedy, Tay; Hambidge, Michael

    2011-01-01

    Male and female infants from rural Ethiopia were tested to investigate relations among hemoglobin (Hb), anthropometry, and attention. A longitudinal design was used to examine differences in attention performance from 6 (M = 24.9 weeks, n = 89) to 9 months of age (M = 40.6 weeks, n = 85), differences hypothesized to be related to changes in iron…

  9. Ultrasonic processing for recovery of chicken erythrocyte hemoglobin

    Hemoglobin from chicken blood has been shown to be a good substitute for synthetic polymeric flocculants. One stage of processing the blood entails breaking open the cells and releasing the cytoplasmic contents; in the present study, we investigate the use of ultrasonic processing at this stage. Was...

  10. The Relationship Between Hemoglobin Level and Intellectual Function.

    Munro, Nancy

    In a study to learn whether or not poor nutrition, as indicated by low hemoglobin levels, affects intelligence and behavior, 113 Head Start children in Missoula, Montana took part. Group testing with the Lorge Thorndike Intelligence Test and individual testing with the Wechsler and Primary Scale of Intelligence or Wechsler Intelligence Scale for…

  11. Human macrophage hemoglobin-iron metabolism in vitro

    Custer, G.; Balcerzak, S.; Rinehart, J.

    1982-01-01

    An entirely in vitro technique was employed to characterize hemoglobin-iron metabolism by human macrophages obtained by culture of blood monocytes and pulmonary alveolar macrophages. Macrophages phagocytized about three times as many erythrocytes as monocytes and six times as many erythrocytes as pulmonary alveolar macrophages. The rate of subsequent release of 59 Fe to the extracellular transferrin pool was two- to fourfold greater for macrophages as compared to the other two cell types. The kinetics of 59 Fe-transferrin release were characterized by a relatively rapid early phase (hours 1-4) followed by a slow phase (hours 4-72) for all three cell types. Intracellular movement of iron was characterized by a rapid shift from hemoglobin to ferritin that was complete with the onset of the slow phase of extracellular release. A transient increase in 59 Fe associated with an intracellular protein eluting with transferrin was also observed within 1 hour after phagocytosis. The process of hemoglobin-iron release to extracellular transferrin was inhibited at 4 degrees C but was unaffected by inhibitory of protein synthesis, glycolysis, microtubule function, and microfilament function. These data emphasize the rapidity of macrophage hemoglobin iron metabolism, provide a model for characterization of this process in vitro, and in general confirm data obtained utilizing in vivo animal models

  12. The diluvial rains of Saguenay-Lac-Saint-Jean : status one year after

    Henri, N.; Beauchemin, G.; Alonso, M.; Gelinas, M.

    1997-01-01

    The status of damages and reconstruction in the Saguenay-Lac-Saint-Jean region, one year after the catastrophic torrential rain storm of July 1996 was presented. Numerous detailed maps and photographs of the principal washed-out, destroyed and damaged regions were presented, along with maps and photographs of the same areas after reconstruction, repair and landscaping. The maps show the different river beds, urban, and rural districts that were subjected to the catastrophic washouts, landslides and soil collapses. The report also includes a summary of the repair costs by municipal regions and the financial aid received by the region to help in the reconstruction effort. tabs., figs

  13. Role of radiation therapy in bladder cancer in the Saguenay-Lac Saint-Jean area

    Brochet, F.; Barrette, L.R.

    1998-01-01

    Bladder cancer is more frequent in Quebec, especially in Saguenay-Lac Saint-Jean than in other Canadian provinces and in the USA. From 1983 to 1996, only 78 patients presenting with bladder cancer received external beam radiation therapy. Sixty-eight were treated with curative intent Overall survival rates were 70% at 3 years, 66% at 5 years, and 40% at 10 years. Retrospective analysis of these cases and literature review show that preoperative radiation therapy is useful in the management of bladder cancer, especially in T3 tumors. It is also useful for patients whose tumor objectively responds to radiation therapy, without an increase in morbidity. (authors)

  14. FTIR ANALYSIS OF PAINTING MATERIALS FROM THE CHURCH SAINT PARASCHIVA, OF POIENILE IZEI, MARAMUREŞ, ROMANIA

    Constantin MARUŢOIU

    2011-03-01

    Full Text Available This paper presents the research and the t results of FTIR analyses on samples of immobile paintings on the wooden walls, taken from the Church Saint Paraschiva from the Village of Poienile Izei, county of Maramureş,Romania, a UNESCO World Heritage List monument. These analyses were meant to certify the type and origin of the materials used in the grounding and paint layers of the late 18th c. pictures inside this wooden church. The results obtained, revealed us that other materials had been used than expected. Results also can help in the future conservation-restoration intervention, especially in cleaning and retouching.

  15. Study of production by cosmic radiation of krypton and xenon in the Saint-Severin meteorite

    Lavielle, B.

    1987-01-01

    The concentrations of Kr and Xe isotropes have been measured by a high sensitivity mass spectrometry technique in 11 samples from a core of the Saint-Severin meteorite. On the basis of our results, we were able to show the role of the shielding depth on the production of Kr and Xe by cosmic ray bombardment. More-over, the experimental results for krypton were compared with calculated values obtained by the Reedy and Arnold model (1972) adapted to cosmic ray irradiation of small spherical objects. Our elaboration of a new systematics of nuclear reactions has lead to a good agreement between experiments and calculations within this model [fr

  16. How Doubt Built the Foundation of the Church of Jesus Christ of Latter-Day Saints

    Hortin, Joshua

    2013-01-01

    Dr. Gregory A. Prince at this year’s annual Arrington Lecture gave an intriguing biography of Leonard J. Arrington, focusing particularly on Arrington’s own interplay between faith and doubt. Arrington’s intellectual journey was sparked as he entered the world of academia and had his beliefs on evolution directly challenged. Having been raised as a member of the Church of Jesus Christ of Latter-­‐ day Saints (LDS or Mormon), he struggled with reconciling a Creationist viewpoint to that taught...

  17. Marées et touristes au Mont-Saint-Michel

    Fernand Verger

    2001-09-01

    Full Text Available L’imaginaire collectif fait la plus grande place au phénomène des grandes marées dans la baie du Mont-Saint-Michel, mais la fréquentation touristique n’est que faiblement déterminée par l’occurrence des grandes marées, malgré l’existence d’un public spécifique, relativement peu nombreux, attiré par le spectacle du mascaret.

  18. La estructura del poder en la "Mémoires" de Saint-Simon

    Robles Vázquez, Carmen

    2004-01-01

    Análisis de las diferentes formas en que Saint-Simon presenta en sus Memorias el poder, y de qué manera se manifiesta éste en sus aspectos económicos, políticos, religiosos, familiares y sociales, tanto durante los últimos años del reinado de Luis XIV como durante la regencia de Felipe de Orleáns en una sociedad teocrática y absolutista, fuertemente jerarquizada, característica del Antiguo Régimen.

  19. L’entre-soi élitaire à Saint-Barthélemy

    Cousin, B.; Chauvin, S.

    2012-01-01

    Après un siècle de dénuement, l’île antillaise de Saint-Barthélemy a connu un développement continu depuis sa « découverte » par la grande bourgeoisie américaine à la fin des années 1950. Centrées autour de la villégiature de luxe, les activités économiques de l’île ont nécessité le recours

  20. Religious [Out]Laws: An Analysis of the 2008 Fundamentalist Latter-day Saints Raid

    Ambutter, Cassie Nicole

    2014-01-01

    In early April 2008, based on a single allegation of child abuse, the state of Texas and Child Protective Services (CPS) executed a raid on the Fundamentalist Latter-day Saints, a polygamous Mormon group living on the "Yearning for Zion" ranch in Eldorado, Texas. The raid involved the immediate removal of over 400 children who were then placed in protective custody in nearby San Angelo. Despite the fact that the initial abuse allegation was determined to be a hoax, the raid was the catalyst f...

  1. Inventory and action plan for greenhouse gas emissions and capture in the Lower Saint Lawrence

    Granger, F.; Avoine, G.; Michon, P.-Y.; Drainville, L.

    2003-01-01

    The authors reported on a project designed to provide farmers with concrete information based on data from their enterprise to develop an action plan for the reduction of greenhouse gas emissions. This project involved completing an inventory of greenhouse gas emissions and capture for seven farms located in the Lower Saint Lawrence region of Quebec. The authors presented a balance sheet and action plan for the region under study. A total of six priorities were identified. They encompassed measures such as the optimization of nitrogen management in agricultural soils, to increasing the capture rate of carbon dioxide, and reducing the use of fossil fuels. 6 refs., 6 figs

  2. Das Weiblich-Männliche in der saint-simonistischen Debatte um 1830

    Paola Ferruta

    2009-12-01

    Full Text Available D’une part, ma contribution interroge les concepts saint-simoniens de « masculin » et de « féminin » en se basant sur le cas concret de Pierre Leroux, adepte du saintsimonisme dès 1830 à Paris ; d’autre part, elle revient sur la notion d’identité sexuée, ainsi que sur sa variabilité intrinsèque. L’initiative politique et théorétique de Leroux au sein du groupe saint-simonien présente un intérêt historique, car elle a notamment participé à la diffusion au cours du XIXe siècle des croyances en la métempsychose et en des « vérités mystiques ». Ces « vérités mystiques » ont contribué à définir les identités de « genre » dans la pensée de Leroux et à façonner autour de 1840 son concept de « solidarité ». Or la question d’une « politique de la solidarité », et particulièrement de la « solidarité de genre » – c’est-à-dire d’une solidarité féminine qui ne fasse pas du féminisme une politique identitaire – est réactualisée dans le débat contemporainDie saint-simonistischen Begriffe „männlich“ und „weiblich“ sollen hier anhand des Falles von Pierre Leroux, einem Pariser Aktivisten des Saint-Simonismus, betrachtet werden. Es wird u. a. dessen Vorstellung von geschlechtlicher Identität und ihrer inhärenten Variabilität ins Auge gefasst. Die politische und theoretische Initiative Leroux’ ist insofern von historischem Interesse als sie zur Verbreitung des Glaubens an die Metempsychose und an „mystische Wahrheiten“ beitrug. Diese „mystischen Wahrheiten“ steuerten in Leroux’ Denken zur Definition der Geschlechteridentitäten bei und formten um 1840 seinen Begriff von „Solidarität“. Die Frage der „Politik der Solidarität“ ist heute noch aktuell, insbesondere einer „Geschlechtsidentität“, d. h. einer weiblichen Solidarität, die den Feminismus nicht als Identitätspolitik artikuliert.

  3. Developing Semi-Analytical solutions for Saint-Venant Equations in the Uniform Flow Region

    M.M. Heidari

    2016-09-01

    Full Text Available Introduction: Unsteady flow in irrigation systems is the result of operations in response to changes in water demand that affect the hydraulic performance networks. The increased hydraulic performance needed to recognize unsteady flow and quantify the factors affecting it. Unsteady flow in open channels is governed by the fully dynamic Saint Venant equation, which express the principles of conservation of mass and momentum. Unsteady flow in open channels can be classified into two types: routing and operation-type problems. In the routing problems, The Saint Venant equations are solved to get the discharge and water level in the time series. Also, they are used in the operation problem to compute the inflow at the upstream section of the channel according to the prescribed downstream flow hydrographs. The Saint Venant equation has no analytical solution and in the majority cases of such methods use numerical integration of continuity and momentum equations, and are characterized by complicated numerical procedures that are not always convenient for carrying out practical engineering calculations. Therefore, approximate methods deserve attention since they would allow the solution of dynamic problems in analytical form with enough exactness. There are effective methods for automatic controller synthesis in control theory that provide the required performance optimization. It is therefore important to get simplified models of irrigation canals for control design. It would be even more interesting to have linear models that explicitly depend on physical parameters. Such models would allow one to, handle the dynamics of the system with fewer parameters, understand the impact of physical parameters on the dynamics, and facilitate the development a systematic design method. Many analytical models have been proposed in the literature, Most of them have been obtained in the frequency domain by applying Laplace transform to linearized Saint

  4. The subunit structure of the extracellular hemoglobin of Biomphalaria glabrata

    Arndt, Marcio H.L.; Naves, Cristiani F.; Xavier, Luciana P.; Santoro, Marcelo M.

    1997-01-01

    Full text. The hemoglobin of Biomphalaria glabrata was purified to homogeneity by a two step purification protocol using a gel filtration column (Superose 6 HR/Pharmacia ) followed by an anion exchange chromatography (MONO-Q Sepharose/Pharmacia). The dissociation products were analysed by a 5 - 15 % Polyacrylamide gel electrophoresis containing Sodium Dodecyl Sulfate (SDS-PAGE) giving a band of 270 K Daltons and a band of 180 K Daltons after reduction with β-mercaptoethanol. The same profile was obtained in a 3.5 % Agarose gel electrophoresis containing SDS (SDS-AGE) showing additional bands of higher molecular weight. These bands were proposed to be monomers, dimers and trimers and, after reduction in a Bidimensional SDS-AGE, the proposed monomers and dimers were decomposed in two and four bands that were interpreted as 1 - 4 chains. The hemoglobin was digested by four different proteases ( Thrombin, Trypsin, Chymotrypsin and Subtilisin ) showing several equivalent fragments with molecular weights multiples of its minimum molecular weight ( 17.7 K Daltons). The circular dichroism spectrum of the protein showed a characteristic high α-helix content. We proposed that this hemoglobin is a pentamer of approx. 360 K Daltons subunits each formed by two 180 K Daltons chains linked in pairs by disulfide bridges and each of these chains comprises ten Heme binding domains. These data were compared to other Planorbidae extracellular hemoglobins. Up to now, the quaternary structure of this hemoglobin (shape and disposition of the subunits) is unknown. It is intended to elucidate its structure by Small Angle X-Ray Scattering in Brazilian National Laboratory of Synchrotron Light (LNLS). (author)

  5. Hemoglobin Kinetics and Long-term Prognosis in Heart Failure.

    Díez-López, Carles; Lupón, Josep; de Antonio, Marta; Zamora, Elisabet; Domingo, Mar; Santesmases, Javier; Troya, Maria-Isabel; Boldó, Maria; Bayes-Genis, Antoni

    2016-09-01

    The influence of hemoglobin kinetics on outcomes in heart failure has been incompletely established. Hemoglobin was determined at the first visit and at 6 months. Anemia was defined according to World Health Organization criteria (hemoglobin < 13g/dL for men and hemoglobin < 12g/dL for women). Patients were classified relative to their hemoglobin values as nonanemic (both measurements normal), transiently anemic (anemic at the first visit but not at 6 months), newly anemic (nonanemic initially but anemic at 6 months), or permanently anemic (anemic in both measurements). A total of 1173 consecutive patients (71.9% men, mean age 66.8±12.2 years) were included in the study. In all, 476 patients (40.6%) were considered nonanemic, 170 (14.5%) had transient anemia, 147 (12.5%) developed new-onset anemia, and 380 (32.4%) were persistently anemic. During a follow-up of 3.7±2.8 years after the 6-month visit, 494 patients died. On comprehensive multivariable analyses, anemia (P < .001) and the type of anemia (P < .001) remained as independent predictors of all-cause mortality. Compared with patients without anemia, patients with persistent anemia (hazard ratio [HR] = 1.62; 95% confidence interval [95%CI], 1.30-2.03; P < .001) and new-onset anemia (HR = 1.39; 95%CI, 1.04-1.87, P = .03) had higher mortality, and even transient anemia showed a similar trend, although without reaching statistical significance (HR = 1.31; 95%CI, 0.97-1.77, P = .075). Anemia, especially persistent and of new-onset, and to a lesser degree, transient anemia, is deleterious in heart failure. Copyright © 2016 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  6. Anemia and hemoglobin levels among Indigenous Xavante children, Central Brazil.

    Ferreira, Aline Alves; Santos, Ricardo Ventura; Souza, July Anne Mendonça de; Welch, James R; Coimbra, Carlos E A

    2017-01-01

    To evaluate the prevalence of anemia, mean hemoglobin levels, and the main nutritional, demographic, and socioeconomic factors among Xavante children in Mato Grosso State, Brazil. A survey was conducted with children under 10 years of age in two indigenous Xavante communities within the Pimentel Barbosa Indigenous Reserve. Hemoglobin concentration levels, anthropometric measurements, and socioeconomic/demographic data were collected by means of clinical measurements and structured interviews. The cut-off points recommended by the World Health Organization were used for anemia classification. Linear regression analyses with hemoglobin as the outcome and Poisson regression with robust variance and with the presence or absence of anemia as outcomes were performed (95%CI). Lower mean hemoglobin values were observed in children under 2 years of age, without a significant difference between sexes. Anemia was observed among 50.8% of children overall, with the highest prevalence among children under 2 years of age (77.8%). Age of the child was inversely associated with the occurrence of anemia (adjusted PR = 0.60; 95%CI 0.38-0.95) and mean hemoglobin values increased significantly with age. Greater height-for-age z-score values reduced the probability of having anemia by 1.8 times (adjusted PR = 0.59; 95%CI 0.34-1.00). Presence of another child with anemia within the household increased the probability of the occurrence of anemia by 52.9% (adjusted PR = 1.89; 95%CI 1.16-3.09). Elevated levels of anemia among Xavante children reveal a disparity between this Indigenous population and the national Brazilian population. Results suggest that anemia is determined by complex and variable relationships between socioeconomic, sociodemographic, and biological factors.

  7. A microfluidic approach for hemoglobin detection in whole blood

    Nikita Taparia

    2017-10-01

    Full Text Available Diagnosis of anemia relies on the detection of hemoglobin levels in a blood sample. Conventional blood analyzers are not readily available in most low-resource regions where anemia is prevalent, so detection methods that are low-cost and point-of-care are needed. Here, we present a microfluidic approach to measure hemoglobin concentration in a sample of whole blood. Unlike conventional approaches, our microfluidic approach does not require hemolysis. We detect the level of hemoglobin in a blood sample optically by illuminating the blood in a microfluidic channel at a peak wavelength of 540 nm and measuring its absorbance using a CMOS sensor coupled with a lens to magnify the image onto the detector. We compare measurements in microchannels with channel heights of 50 and 115 μm and found the channel with the 50 μm height provided a better range of detection. Since we use whole blood and not lysed blood, we fit our data to an absorption model that includes optical scattering in order to obtain a calibration curve for our system. Based on this calibration curve and data collected, we can measure hemoglobin concentration within 1 g/dL for severe cases of anemia. In addition, we measured optical density for blood flowing at a shear rate of 500 s-1 and observed it did not affect the nonlinear model. With this method, we provide an approach that uses microfluidic detection of hemoglobin levels that can be integrated with other microfluidic approaches for blood analysis.

  8. Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey Veng, Cambodia.

    Karakochuk, Crystal D; Whitfield, Kyly C; Barr, Susan I; Lamers, Yvonne; Devlin, Angela M; Vercauteren, Suzanne M; Kroeun, Hou; Talukder, Aminuzzaman; McLean, Judy; Green, Timothy J

    2015-01-01

    Anemia is common in Cambodian women. Potential causes include micronutrient deficiencies, genetic hemoglobin disorders, inflammation, and disease. We aimed to investigate factors associated with anemia (low hemoglobin concentration) in rural Cambodian women (18-45 y) and to investigate the relations between hemoglobin disorders and other iron biomarkers. Blood samples were obtained from 450 women. A complete blood count was conducted, and serum and plasma were analyzed for ferritin, soluble transferrin receptor (sTfR), folate, vitamin B-12, retinol binding protein (RBP), C-reactive protein (CRP), and α1 acid glycoprotein (AGP). Hemoglobin electrophoresis and multiplex polymerase chain reaction were used to determine the prevalence and type of genetic hemoglobin disorders. Overall, 54% of women had a genetic hemoglobin disorder, which included 25 different genotypes (most commonly, hemoglobin E variants and α(3.7)-thalassemia). Of the 420 nonpregnant women, 29.5% had anemia (hemoglobin 8.3 mg/L), hemoglobin disorders, respectively. There was no biochemical evidence of vitamin A deficiency (RBP 5 mg/L) and 26% (AGP >1 g/L) of nonpregnant women, respectively. By using an adjusted linear regression model, the strongest predictors of hemoglobin concentration were hemoglobin E homozygous disorder and pregnancy status. Other predictors were 2 other heterozygous traits (hemoglobin E and Constant Spring), parity, RBP, log ferritin, and vitamin B-12. Multiple biomarkers for anemia and iron deficiency were significantly influenced by the presence of hemoglobin disorders, hence reducing their diagnostic sensitivity. Further investigation of the unexpectedly low prevalence of IDA in Cambodian women is warranted. © 2015 American Society for Nutrition.

  9. Whose Knowledge, Whose Values? The Contribution of Local Knowledge to Education Policy Processes: A Case Study of Research Development Initiatives in the Small State of Saint Lucia

    Holmes, Keith; Crossley, Michael

    2004-01-01

    This paper draws upon a case study of education in the small Caribbean state of Saint Lucia (population 154,000) to examine how local knowledge and values can influence the education policy process. It is argued that recent research development initiatives have strengthened the ability of Saint Lucia to mediate international education agendas to…

  10. MR Imaging-derived Oxygen-Hemoglobin Dissociation Curves and Fetal-Placental Oxygen-Hemoglobin Affinities.

    Avni, Reut; Golani, Ofra; Akselrod-Ballin, Ayelet; Cohen, Yonni; Biton, Inbal; Garbow, Joel R; Neeman, Michal

    2016-07-01

    Purpose To generate magnetic resonance (MR) imaging-derived, oxygen-hemoglobin dissociation curves and to map fetal-placental oxygen-hemoglobin affinity in pregnant mice noninvasively by combining blood oxygen level-dependent (BOLD) T2* and oxygen-weighted T1 contrast mechanisms under different respiration challenges. Materials and Methods All procedures were approved by the Weizmann Institutional Animal Care and Use Committee. Pregnant mice were analyzed with MR imaging at 9.4 T on embryonic days 14.5 (eight dams and 58 fetuses; imprinting control region ICR strain) and 17.5 (21 dams and 158 fetuses) under respiration challenges ranging from hyperoxia to hypoxia (10 levels of oxygenation, 100%-10%; total imaging time, 100 minutes). A shorter protocol with normoxia to hyperoxia was also performed (five levels of oxygenation, 20%-100%; total imaging time, 60 minutes). Fast spin-echo anatomic images were obtained, followed by sequential acquisition of three-dimensional gradient-echo T2*- and T1-weighted images. Automated registration was applied to align regions of interest of the entire placenta, fetal liver, and maternal liver. Results were compared by using a two-tailed unpaired Student t test. R1 and R2* values were derived for each tissue. MR imaging-based oxygen-hemoglobin dissociation curves were constructed by nonlinear least square fitting of 1 minus the change in R2*divided by R2*at baseline as a function of R1 to a sigmoid-shaped curve. The apparent P50 (oxygen tension at which hemoglobin is 50% saturated) value was derived from the curves, calculated as the R1 scaled value (x) at which the change in R2* divided by R2*at baseline scaled (y) equals 0.5. Results The apparent P50 values were significantly lower in fetal liver than in maternal liver for both gestation stages (day 14.5: 21% ± 5 [P = .04] and day 17.5: 41% ± 7 [P hemoglobin dissociation curves with a shorter protocol that excluded the hypoxic periods was demonstrated. Conclusion MR imaging

  11. High Leptospira seroprevalence in captive and wild-caught vervet monkeys ( Chlorocebus sabeus) on the Caribbean island of Saint Kitts.

    Rajeev, Sreekumari; Conan, Anne; Pratt, Nicola; Beierschmitt, Amy; Palmour, Roberta

    2017-11-01

    Leptospirosis is a zoonotic disease of global importance. Very little information is available on Leptospira infection in nonhuman primates. We report herein a high seroprevalence (49.4%; 95% confidence interval: 41.6-57.2%) to Leptospira serovars in vervet monkeys ( Chlorocebus sabeus) on the Caribbean island of Saint Kitts. Monkeys bred in captivity ( n = 81) had a significantly higher seroprevalence compared to wild-caught monkeys ( n = 81; p Leptospira serovars and seroconversion occurs in wild and captive vervet monkeys on the Caribbean island of Saint Kitts. Further studies are warranted to better understand epidemiology, transmission, pathology, and possible reservoir status in this species.

  12. High-rise construction in the Saint Petersburg agglomeration in 1703–1950s

    Sementsov Sergey

    2018-01-01

    Full Text Available Regularities of high-rise construction (implemented projects and developments in Saint Petersburg and the Saint Petersburg agglomeration since the foundation of the city in 1703 till the 1950s are considered. Based on these regularities, a single spatially developed system of vertical dominants is formed. High-rise construction in the city and its suburbs started in the 1710s and continues up to the present time. In the considered decades (1703–1950s, high-rise construction mostly performed urban-planning functions (with vertical and symbolic dominants, relying on patterns of the visual perception of man-made landscapes under development. Since the 1710s, the construction of vertical dominants (mainly temples, spires of towers, lighthouses, etc. of five ranks (depending on the altitude range and in relation to the background development was conducted in territories of the entire agglomeration. These dominants were arranged in landscapes of the city and suburbs with almost mathematically precise accuracy and according to special regulations. Such dominants obtained particular descriptive and silhouette characteristics in accordance with the conditions of spatial perception. In some periods of city development, attempts were made to create monuments (symbolic dominants of specific height and include those in the spatial system of high-rise dominants as significant elements of the city silhouette.

  13. New optical museum at Saint-Petersburg for education and training

    Vasil'ev, V. N.; Stafeef, S. K.; Tomilin, M. G.

    2009-06-01

    Nowadays the educational problem of teaching optics and photonics is to attract the young generation to the wonderful and magic world of light, optical science, technology and systems. The main issue is to explain that in the course of last several hundred years optics has been representing the most clear world view for humanity. In fact, the optics itself is a multidisciplinary complex of independent scientific directions, and, moreover, it has always been a generator of new fields of knowledge. Besides, optics and photonics are the fields within which the most fundamental problems of today's reality are to be resolved. It is absolutely necessary to encourage our scholars in getting optics and photonics education as an alternative physical basis to gaining solely computer knowledge. The main obstacle is the poor connection between program of optical education and the real optical researches, disintegration of different branches of the optical science, the demographic situation, some problems with teaching mathematics and physics at schools, and the collision between traditional educational methods and the mentality of the new generation. In Russia the Saint-Petersburg State University of Information Technologies, Mechanics and Optics offers partial solution to these problems: the organization of a real place for interactive optical science in a form of a new museum of optics, intended for education and training, seems to be the most effective way. This was the main reason for establishing such a museum in Saint-Petersburg at the end of 2008.

  14. Operator modeling of a loss-of-pumping accident using MicroSAINT

    Olsen, L.M.

    1992-01-01

    The Savannah River Laboratory (SRL) human factors group has been developing methods for analyzing nuclear reactor operator actions during hypothetical design-basis accident scenarios. The SRL reactors operate at a lower temperature and pressure than power reactors resulting in accident sequences that differ from those of power reactors. Current methodology development is focused on modeling control room operator response times dictated by system event times specified in the Savannah River Site Reactor Safety Analysis Report (SAR). The modeling methods must be flexible enough to incorporate changes to hardware, procedures, or postulated system event times and permit timely evaluation. The initial model developed was for the loss-of-pumping accident (LOPA) because a significant number of operator actions are required to respond to this postulated event. Human factors engineers had been researching and testing a network modeling simulation language called MicroSAINT to simulate operators' personal and interpersonal actions relative to operating system events. The LOPA operator modeling project demonstrated the versatility and flexibility of MicroSAINT for modeling control room crew interactions

  15. AN ORTHODOX THINKER AND A ROMANIAN HEART: THE SAINT HIERARCH ANTHIM

    Henrieta Anişoara ŞERBAN

    2016-10-01

    Full Text Available 2016 is an anniversary year, dedicated to the Saint Hierarch Anthim, a multi-faced personality of Georgian origin, but with a Romanian accomplished life. He was a true Orthodox believer, a Hierarch of our Orthodox Church in Wallachia and a deep thinker, who lived through the teachings of the faith. At the same time, he was a good manager and a philanthropist, a scholar, a polyglot, a calligrapher, a typographer, a Church architect, an orator turned writer, a painter and a sculptor. His great homiletic work entitled Didahiile sends to Didache, the oldest post-Bible Christian text, famous at Constantinople, known also as The Teachings of the Twelve Apostles (The Teachings of the Lord to the Gentiles (or Nations by the Twelve Apostles. The study approaches and develops these dimensions of the personality and of the thought of the Saint Hierarch Anthim, in order to emphasize both his life and his work as an esteemed symbol of the Orthodox faith.

  16. Effects of Protection and Sediment Stress on Coral Reefs in Saint Lucia.

    Bégin, Chantale; Schelten, Christiane K; Nugues, Maggy M; Hawkins, Julie; Roberts, Callum; Côté, Isabelle M

    2016-01-01

    The extent to which Marine Protected Areas (MPAs) benefit corals is contentious. On one hand, MPAs could enhance coral growth and survival through increases in herbivory within their borders; on the other, they are unlikely to prevent disturbances, such as terrestrial runoff, that originate outside their boundaries. We examined the effect of spatial protection and terrestrial sediment on the benthic composition of coral reefs in Saint Lucia. In 2011 (10 to 16 years after MPAs were created), we resurveyed 21 reefs that had been surveyed in 2001 and analyzed current benthic assemblages as well as changes in benthic cover over that decade in relation to protection status, terrestrial sediment influence (measured as the proportion of terrigenous material in reef-associated sediment) and depth. The cover of all benthic biotic components has changed significantly over the decade, including a decline in coral and increase in macroalgae. Protection status was not a significant predictor of either current benthic composition or changes in composition, but current cover and change in cover of several components were related to terrigenous content of sediment deposited recently. Sites with a higher proportion of terrigenous sediment had lower current coral cover, higher macroalgal cover and greater coral declines. Our results suggest that terrestrial sediment is an important factor in the recent degradation of coral reefs in Saint Lucia and that the current MPA network should be complemented by measures to reduce runoff from land.

  17. The “Enemy” of the Saint in the Vita Fulgentii

    Isabella D'Auria

    2015-06-01

    Full Text Available This paper aims to analyze the traits that characterize the “enemy” of the saint in the Vita Fulgentii. The work tells in twenty-nine chapters the life of the bishop of Ruspe Fulgentius, troubled by exile and persecutions both in the monastic phase and in the episcopal one, in the context of the vandalic invasion in Africa between 5th and 6th century. The “enemy”, that identifies, in the most cases, with the invader of arian faith, presents a stereotyped nature, summarizing the tipical characteristics of barbarian and the ones specific to the heterodox. In order to achieve the goal of the reader’s moral edification, the text presents antithetical models, the saint ant his opposer, and all the account revolves around this dialectic; so it is worthy of interest to pick out the elements that define, throught a relationship of opposition, the collective identities, that in this text are represented by Catholics invaded and by barbarian and heretic invaders.

  18. Nuclear safety and radiation protection report of the Saint-Laurent-des-Eaux nuclear facilities - 2011

    2012-01-01

    This safety report was established under the article 21 of the French law no. 2006-686 of June 13, 2006 relative to nuclear safety and information transparency. It presents, first, the facilities of the Saint-Laurent-des-Eaux nuclear power plant (Saint-Laurent-Nouan (FR)): 2 partially dismantled graphite-gas reactors and a graphite sleeves storage silo (INB 46 and 74), and 2 PWR reactors in operation (INB 100). Then, the nuclear safety and radiation protection measures taken regarding the facilities are reviewed: nuclear safety definition, radiation protection of intervening parties, safety and radiation protection improvement paths, crisis management, external and internal controls, technical situation of facilities, administrative procedures in progress. The incidents and accidents which occurred in 2011, are reported as well as the radioactive and non-radioactive (chemical, thermal) effluents discharge in the environment. Finally, The radioactive materials and wastes generated by the facilities are presented and sorted by type of waste, quantities and type of conditioning. Other environmental impacts (noise, microbial proliferation in cooling towers) are presented with their mitigation measures. Actions in favour of transparency and public information are presented as well. The document concludes with a glossary and a list of recommendations from the Committees for health, safety and working conditions. (J.S.)

  19. Nuclear safety and radiation protection report of the Saint-Laurent-des-Eaux nuclear facilities - 2010

    2011-06-01

    This safety report was established under the article 21 of the French law no. 2006-686 of June 13, 2006 relative to nuclear safety and information transparency. It presents, first, the facilities of the Saint-Laurent-des-Eaux nuclear power plant (Saint-Laurent-Nouan (FR)): 2 partially dismantled graphite-gas reactors and a graphite sleeves storage silo (INB 46 and 74), and 2 PWR reactors in operation (INB 100). Then, the nuclear safety and radiation protection measures taken regarding the facilities are reviewed: nuclear safety definition, radiation protection of intervening parties, safety and radiation protection improvement paths, crisis management, external and internal controls, technical situation of facilities, administrative procedures in progress. The incidents and accidents which occurred in 2010, are reported as well as the radioactive and non-radioactive (chemical, thermal) effluents discharge in the environment. Finally, The radioactive materials and wastes generated by the facilities are presented and sorted by type of waste, quantities and type of conditioning. Other environmental impacts (noise, microbial proliferation in cooling towers) are presented with their mitigation measures. Actions in favour of transparency and public information are presented as well. The document concludes with a glossary and a list of recommendations from the Committees for health, safety and working conditions. (J.S.)

  20. High-rise construction in the Saint Petersburg agglomeration in 1703-1950s

    Sementsov, Sergey; Akulova, Nadezhda; Kurakina, Severina

    2018-03-01

    Regularities of high-rise construction (implemented projects and developments) in Saint Petersburg and the Saint Petersburg agglomeration since the foundation of the city in 1703 till the 1950s are considered. Based on these regularities, a single spatially developed system of vertical dominants is formed. High-rise construction in the city and its suburbs started in the 1710s and continues up to the present time. In the considered decades (1703-1950s), high-rise construction mostly performed urban-planning functions (with vertical and symbolic dominants), relying on patterns of the visual perception of man-made landscapes under development. Since the 1710s, the construction of vertical dominants (mainly temples, spires of towers, lighthouses, etc.) of five ranks (depending on the altitude range and in relation to the background development) was conducted in territories of the entire agglomeration. These dominants were arranged in landscapes of the city and suburbs with almost mathematically precise accuracy and according to special regulations. Such dominants obtained particular descriptive and silhouette characteristics in accordance with the conditions of spatial perception. In some periods of city development, attempts were made to create monuments (symbolic dominants) of specific height and include those in the spatial system of high-rise dominants as significant elements of the city silhouette.

  1. Identifying Key Stakeholder Groups for Implementing a Place Branding Policy in Saint Petersburg

    Kulibanova V. V.

    2017-10-01

    Full Text Available Regional brands have become a valuable intangible asset and a crucial competitive resource for forging partnerships. An effective place branding policy is impossible without a precise understanding of the interests of stakeholder groups. It is essential to realize that each region is unique in its own way. Territories differ in the structure of stakeholders, their influence on regional development, and the range of leverages over regional decision-makers. This study aims to give a more precise definition of key groups of stakeholders in Saint Petersburg place branding, and to identify them. The authors employ the method of theoretical and empirical typology of a territory’s stakeholders within a theoretical framework proposed by E. Freeman, P. Kotler, S. Zenker, and E. Brown. The article defines the concept of key regional stakeholders and identifies them. The proposed target audience (stakeholder group model for a place branding policy is tested on the case of Saint Petersburg. The authors show that each target audience of place marketing requires an individual policy. This is explained by the fact that each group enjoys its unique features that should be taken into account when creating and transmitting messages.

  2. Nondestructive evaluation of the oxidation and strength of the Fort Saint Vrain HTGR support block

    Tingey, G.L.; Posakony, G.J.; Morgan, W.C.; Prince, J.M.; Hill, R.W.; Lessor, D.L.

    1982-04-01

    Non-destructive detection of changes in the strength of graphite support structures in a HTGR appears to be feasible using sonic velocity measurements where access for through transmission is possible. Therefore, future HTGR designs should consider providing such access. Where access is not available, strength changes can be correlated with oxidation profiles in the support member. These oxidation profiles can be determined non-destructively by a combination of eddy current measurements to detect near surface oxidation and sonic backscattering measurements designed to determine oxidation in depth. The Fort Saint Vrain reactor provides an operating reactor to test the applicability of the eddy current and sonic backscattering techniques for determination of oxidation in a support block. Furthermore, such tests in Fort Saint Vrain will supply base line data which will be useful in assuring an adequate strength of the support structure for the lifetime of the reactor. Equipment is, therefore, being developed for tests to be conducted during the next major refueling of the reactor

  3. Effects of Protection and Sediment Stress on Coral Reefs in Saint Lucia.

    Chantale Bégin

    Full Text Available The extent to which Marine Protected Areas (MPAs benefit corals is contentious. On one hand, MPAs could enhance coral growth and survival through increases in herbivory within their borders; on the other, they are unlikely to prevent disturbances, such as terrestrial runoff, that originate outside their boundaries. We examined the effect of spatial protection and terrestrial sediment on the benthic composition of coral reefs in Saint Lucia. In 2011 (10 to 16 years after MPAs were created, we resurveyed 21 reefs that had been surveyed in 2001 and analyzed current benthic assemblages as well as changes in benthic cover over that decade in relation to protection status, terrestrial sediment influence (measured as the proportion of terrigenous material in reef-associated sediment and depth. The cover of all benthic biotic components has changed significantly over the decade, including a decline in coral and increase in macroalgae. Protection status was not a significant predictor of either current benthic composition or changes in composition, but current cover and change in cover of several components were related to terrigenous content of sediment deposited recently. Sites with a higher proportion of terrigenous sediment had lower current coral cover, higher macroalgal cover and greater coral declines. Our results suggest that terrestrial sediment is an important factor in the recent degradation of coral reefs in Saint Lucia and that the current MPA network should be complemented by measures to reduce runoff from land.

  4. Crystal structure of hemoglobin from the maned wolf (Chrysocyon brachyurus) using synchrotron radiation.

    Fadel, Valmir; Canduri, Fernanda; Olivieri, Johnny R; Smarra, André L S; Colombo, Marcio F; Bonilla-Rodriguez, Gustavo O; de Azevedo, Walter F

    2003-12-01

    Crystal structure of hemoglobin isolated from the Brazilian maned wolf (Chrysocyon brachyurus) was determined using standard molecular replacement technique and refined using maximum-likelihood and simulated annealing protocols to 1.87A resolution. Structural and functional comparisons between hemoglobins from the Chrysocyon brachyurus and Homo sapiens are discussed, in order to provide further insights in the comparative biochemistry of vertebrate hemoglobins.

  5. Hemoglobin A1c (HbA1c) Test: MedlinePlus Lab Test Information

    ... page: https://medlineplus.gov/labtests/hemoglobina1chba1ctest.html Hemoglobin A1c (HbA1c) Test To use the sharing features on this page, please enable JavaScript. What is a hemoglobin A1c (HbA1c) test? A hemoglobin A1c (HbA1c) test measures ...

  6. Hemoglobin levels in persons with depressive and/or anxiety disorders

    Lever-van Milligen, Bianca A.; Vogelzangs, Nicole; Smit, Johannes H.; Penninx, Brenda W. J. H.

    Objective: Both low and high hemoglobin levels lead to more physical diseases, and both are linked to mortality. Low hemoglobin, often classified as anemia, has also been linked to more depressive symptoms, but whether both hemoglobin extremes are associated with depressive disorder and potentially

  7. TECHNIQUES OF EVALUATION OF HEMOGLOBIN OXYGEN SATURATION IN CLINICAL OPHTHALMOLOGY

    S. Yu. Petrov

    2016-01-01

    Full Text Available Oxygen content in body fluids and tissues is an important indicator of life support functions. A number of ocular pathologies, e.g. glaucoma, are of presumable vascular origin which means altered blood supply and oxygen circulation. Most oxygen is transported in the blood in the association with hemoglobin. When passing through the capillaries, hemoglobin releases oxygen, converting from oxygenated form to deoxygenated form. This process is accompanied by the changes in spectral characteristics of hemoglobin which result in different colors of arterial and venous blood. Photometric technique for the measurement of oxygen saturation in blood is based on the differences in light absorption by different forms of hemoglobin. The measurement of saturation is called oximetry. Pulse oximetry with assessment of tissue oxygenation is the most commonly used method in medicine. The degree of hemoglobin oxygen saturation in the eye blood vessels is the most accessible for noninvasive studies during ophthalmoscopy and informative. Numerous studies showed the importance of this parameter for the diagnosis of retinopathy of various genesis, metabolic status analysis in hyperglycemia, diagnosis and control of treatment of glaucoma and other diseases involving alterations in eye blood supply. The specific method for evaluation of oxygen concentration is the measurement of pressure of oxygen dissolved in the blood, i.e. partial pressure of oxygen. In ophthalmological practice, this parameter is measured in anterior chamber fluid evaluating oxygen level for several ophthalmopathies including different forms of glaucoma, for instillations of hypotensive eye drops as well as in vitreous body near to the optic disc under various levels of intraocular pressure. Currently, monitoring of oxygen saturation in retinal blood vessels, i.e. retinal oximetry, is well developed. This technique is based on the assessment of light absorption by blood depending on

  8. Evaluation of non cyanide methods for hemoglobin estimation

    Vinaya B Shah

    2011-01-01

    Full Text Available Background: The hemoglobincyanide method (HiCN method for measuring hemoglobin is used extensively worldwide; its advantages are the ready availability of a stable and internationally accepted reference standard calibrator. However, its use may create a problem, as the waste disposal of large volumes of reagent containing cyanide constitutes a potential toxic hazard. Aims and Objective: As an alternative to drabkin`s method of Hb estimation, we attempted to estimate hemoglobin by other non-cyanide methods: alkaline hematin detergent (AHD-575 using Triton X-100 as lyser and alkaline- borax method using quarternary ammonium detergents as lyser. Materials and Methods: The hemoglobin (Hb results on 200 samples of varying Hb concentrations obtained by these two cyanide free methods were compared with a cyanmethemoglobin method on a colorimeter which is light emitting diode (LED based. Hemoglobin was also estimated in one hundred blood donors and 25 blood samples of infants and compared by these methods. Statistical analysis used was Pearson`s correlation coefficient. Results: The response of the non cyanide method is linear for serially diluted blood samples over the Hb concentration range from 3gm/dl -20 gm/dl. The non cyanide methods has a precision of + 0.25g/dl (coefficient of variation= (2.34% and is suitable for use with fixed wavelength or with colorimeters at wavelength- 530 nm and 580 nm. Correlation of these two methods was excellent (r=0.98. The evaluation has shown it to be as reliable and reproducible as HiCN for measuring hemoglobin at all concentrations. The reagents used in non cyanide methods are non-biohazardous and did not affect the reliability of data determination and also the cost was less than HiCN method. Conclusions: Thus, non cyanide methods of Hb estimation offer possibility of safe and quality Hb estimation and should prove useful for routine laboratory use. Non cyanide methods is easily incorporated in hemobloginometers

  9. Patterns of glycemic control using glycosylated hemoglobin in diabetics

    Arunpreet Singh Kahlon

    2011-01-01

    Full Text Available Aim : Till now estimation of blood glucose is the highly effective method for diagnosing diabetes mellitus but it provides a short-term picture of control. More evidence is required to prove that plasma glucose and glycosylated hemoglobin levels together gives a better estimate of glycemic control and compliance with treatment. Indian diabetes risk score (IDRS is a simplified screening tool for identifying undiagnosed diabetic subjects, requires minimum time, and effort and can help to considerably reduce the costs of screening. Objective : To study patterns of glycemic control using glycosylated hemoglobin in diabetic patients. To find out correlation between levels of plasma glucose and glycosylated hemoglobin in diabetics and to calculate IDRS of the study population. Materials and Methods : A cross sectional study was conducted among 300 known diabetic patients attending outpatient department of a rural medical college in Haryana, India. Following standard procedures and protocols FPG and glycosylated hemoglobin were measured to find out a pattern of glycemic control in them after taking their written and informed consent. A correlation between the levels of glycosylated hemoglobin and fasting blood glucose was also calculated. These patients were made to fill a performa and their demographic and clinical risk factors were noted and based on this, their IDRS was calculated. This was done to validate the IDRS in Indian rural population. Results : Fifty-two percent of the population had fasting plasma glucose level between 125-150 mg/dl, 21% had this level between 151-175 mg/dl. Thirteen percent of the study subjects had HbA1C between 6.5-7.5, more than half (57.3% had this value between 7.5-8.5, 12% and 18% had values between 8.5-9.5 and 9.5-10.5, respectively. Twelve percent of the participants had HbA1C level higher than 10.5. Correlation of fasting plasma glucose level and HbA1C was also studied and found that correlation coefficient came

  10. Patterns of glycemic control using glycosylated hemoglobin in diabetics.

    Kahlon, Arunpreet Singh; Pathak, Rambha

    2011-07-01

    Till now estimation of blood glucose is the highly effective method for diagnosing diabetes mellitus but it provides a short-term picture of control. More evidence is required to prove that plasma glucose and glycosylated hemoglobin levels together gives a better estimate of glycemic control and compliance with treatment. Indian diabetes risk score (IDRS) is a simplified screening tool for identifying undiagnosed diabetic subjects, requires minimum time, and effort and can help to considerably reduce the costs of screening. To study patterns of glycemic control using glycosylated hemoglobin in diabetic patients. To find out correlation between levels of plasma glucose and glycosylated hemoglobin in diabetics and to calculate IDRS of the study population. A cross sectional study was conducted among 300 known diabetic patients attending outpatient department of a rural medical college in Haryana, India. Following standard procedures and protocols FPG and glycosylated hemoglobin were measured to find out a pattern of glycemic control in them after taking their written and informed consent. A correlation between the levels of glycosylated hemoglobin and fasting blood glucose was also calculated. These patients were made to fill a performa and their demographic and clinical risk factors were noted and based on this, their IDRS was calculated. This was done to validate the IDRS in Indian rural population. Fifty-two percent of the population had fasting plasma glucose level between 125-150 mg/dl, 21% had this level between 151-175 mg/dl. Thirteen percent of the study subjects had HbA1C between 6.5-7.5, more than half (57.3%) had this value between 7.5-8.5, 12% and 18% had values between 8.5-9.5 and 9.5-10.5, respectively. Twelve percent of the participants had HbA1C level higher than 10.5. Correlation of fasting plasma glucose level and HbA1C was also studied and found that correlation coefficient came out to be .311. This correlation was found to be statistically

  11. Saints' Relics in Scuola di S. Giorgio degli Schiavoni: An Anti-Ottoman Pantheon

    Ana Marinković

    2018-04-01

    Full Text Available The intensified military campaigns against the Ottomans in the second half of the fifteenth century palpably influenced the cult of saints venerated in Scuola di S. Giorgio degli Schiavoni, both by assimilating new saints, as well as strenghtening the existing cults through indulgences and relic acquisitions. The initial pair of patron saints – St George and St Tryphon, the city patrons of Bar and Kotor – delineated the geographical area where the majority of confraternity members originated from, that is, the Venetian Albania. The inclusion of St Jerome, the patron of Dalmatia, to the confraternal pantheon by Cardinal Bessarion's indulgence issued in 1464, in addition to rounding up the holy patronage to all the Eastern Adriatic Venetian dependencies, also marked the beginning of a strong anti-Ottoman motivation in the scuola's hagiographic horizon. The triple endowment of the Scuola in 1502 – relic acquisition, granting of indulgence, and commission of Carpaccio's monumental cycle – continued to work on the same line, and added to the practical aspect of spiritual support to the members of Venetian troops provenient of the Eastern Adriatic. However, the saints whose relics are today kept in the altar of the lower hall, including the patron saint of the Republic of Dubrovnik, point to an even wider devotional agenda, possibly arranged after the Battle of Lepanto, as the comparative analysis of the reliquaries show.   Le campagne militari contro gli Ottomani intensificatesi nella seconda metà del XV secolo influenzarono palesemente il culto dei santi venerati nella Scuola di S. Giorgio degli Schiavoni, sia attraverso l'assimilazione di nuovi santi, sia tramite il rafforzamento del culto già esistente verso le indulgenze e l'impulso all'acquisizione di reliquie. La prima coppia di santi patroni - San Giorgio e San Trifone, patroni della città di Bar e Cattaro - delimitano l'area geografica da cui proviene la maggior parte dei membri

  12. Análise das variações anatômicas do canal da mandíbula encontradas em radiografias panorâmicas

    Yza Daniella Nunes Andrade

    Full Text Available INTRODUÇÃO: No âmbito da clínica odontológica, o bloqueio do nervo alveolar inferior é o mais utilizado; todavia, diversos estudos têm mostrado as mais altas taxas de fracasso, as quais, normalmente, têm como motivo a falha na observação da posição, da forma e da anatomia dos nervos. Essas falhas decorrentes da variação anatômica do nervo alveolar inferior já vêm sendo estudadas na literatura, através de estudos com a análise de radiografias panorâmicas, como proposto neste estudo. OBJETIVO: O objetivo deste estudo foi verificar a ocorrência e a prevalência das variações anatômicas, bem como a correlação das variações do canal da mandíbula com lado e sexo, que podem ocorrer no canal mandibular, por meio de radiografias panorâmicas de pacientes atendidos no Departamento de Odontologia da Universidade Federal de Sergipe (UFS. MATERIAL E MÉTODO: Foram analisadas 1.500 radiografias panorâmicas de pacientes atendidos pelo Departamento de Odontologia da Universidade Federal de Sergipe (UFS. Imagens radiográficas foram observadas sobre um negatoscópio, utilizando-se uma máscara preta ao redor das radiografias, em ambiente com luminosidade apropriada. RESULTADO: Neste estudo, foram observados 5,3% de bifurcações do canal mandibular; 47,5% de canais altos; 16,8% de canais intermediários; 27,1% de canais baixos, e 8,6% de canais com outras variações. CONCLUSÃO: Baseando-se na altura do canal mandibular, houve maior prevalência dos canais altos do que os demais nas mulheres, sendo que não houve diferenças entre os gêneros com relação aos demais tipos e lados afetados. Na classificação dos canais bífidos, não houve diferença estatisticamente significante entre homens e mulheres. Observou-se que a maior prevalência foi para canais sem bifurcação.

  13. SAINTS toolbox

    Petersen, Anders

    2000-01-01

    En virtuel redskabskasse der bl.a. indeholder materiale om forretningsmodeller, analysemodeller, cases, WebQuests mm.......En virtuel redskabskasse der bl.a. indeholder materiale om forretningsmodeller, analysemodeller, cases, WebQuests mm....

  14. Rare copy of "Life of Saint Volo-dymyr" (Kyiv, 1670 from the manuscript Corpus of Lives of the Saints as a source for the 17th century Kyiv hagiography study

    Bondar N. P.

    2017-01-01

    Full Text Available In the article a rare copy of an old-printed edition of “Life of Saint Volodymyr”, published circa 1670 in the Kyiv-Pechersk Lavra printing-house is characterized. The copy was included to Corpus of Lives of the Saints of the17th-18th centuries from the collection of Church and Archeological museum of Kyiv Ecclesiastical Academy (Fond 301, Unit 416L. According to the modern advances of codicology, archeology, filigranology it became possible to critically review the data of descriptions, which brought new results. The approximate dating of the old-printed edition, which has no title and imprint, is confirmed. The publishing history of “Life of Saint Volodymyr” is analyzed. The research of the copy is accompanied by the complex description of overall manuscript hagiography codex, the analysis of its content, specifics, ownership notes and paper filigrees. Archeographic analysis of Corpus of Lives of the Saints was combined with study of formation of Ukrainian hagiography complex of the second half of the 17th - the early 18th centuries.

  15. Vitreoscilla hemoglobin promotes Salecan production by Agrobacterium sp. ZX09.

    Chen, Yun-mei; Xu, Hai-yang; Wang, Yang; Zhang, Jian-fa; Wang, Shi-ming

    2014-11-01

    Salecan is a novel exopolysaccharide produced by the strain Agrobacterium sp. ZX09, and it is composed of only glucose monomers. The unique chemical composition and excellent physicochemical properties make Salecan a promising material for applications in coagulation, lubrication, protection against acute liver injury, and alleviating constipation. In this study, we cloned the Vitreoscilla hemoglobin gene into a broad-host-range plasmid pCM158. Without antibiotic selection, there was negligible loss of the plasmid in the host Agrobacterium sp. ZX09 after one passage of cultivation. The expression of Vitreoscilla hemoglobin was demonstrated by carbon monoxide (CO) difference spectrum. The engineered strain Agrobacterium sp. ZX09 increased Salecan yield by 30%. The other physiological changes included its elevated respiration rate and cellular invertase activity.

  16. Hemoglobin concentrations and associated factors in adolescentes from Recife, Brazil

    Elisângela Barros Soares Mendonça

    2014-10-01

    Full Text Available OBJECTIVE: To estimate the prevalence of anemia and associated factors in adolescents from the city of Recife in Pernambuco state. METHODS: This is a cross-sectional study, involving a random sample of 256 adolescents of both genders, aged 13 to 18, whose hemoglobin concentrations were evaluated, along with their nutritional status and socioeconomic and demographic characteristics. RESULTS: The prevalence of inadequate hemoglobin concentrations was 10.2% [CI95%=6.7-14.5], reaching levels considered as mild anemia (9 g/dL 0.05, nor with socioeconomic or demographic characteristics (p>0.05. CONCLUSION: Although the prevalence of anemia was low and classified as a mild health problem, preventive nutrition education involving the dissemination of healthy eating habits in schools and encouraging the consumption of iron-rich foods are strongly recommended.

  17. Reticulocyte hemoglobin content (MCHr) in the detection of iron deficiency.

    Urrechaga Igartua, Eloísa; Hoffmann, Johannes J M L; Izquierdo-Álvarez, Silvia; Escanero, Jesús F

    2017-09-01

    Blood hemoglobin (Hb) concentration within the reference interval does not exclude iron deficiency (ID): individuals with normal stores lose iron during a long period before their Hb falls below of the level that is defined as anemia. The process entails a decrease of storage iron, shown by serum ferritin below reference range, followed by iron depletion, eventually leading to iron restricted erythropoiesis; consequence of an imbalance between erythropoietic iron requirements and too low supply is a reduction of Hb synthesis in reticulocytes. We study the potential utility of mean reticulocyte hemoglobin content (MCHr), reported by CELL-DYN Sapphire (Abbott Diagnostics) analyzer, in the detection of ID in non-anemic adults. 207 patients with Hb within the reference range were enrolled. ID was defined as Hb>120g/L (women), >130g/L (men) and serum ferritin iron deficient adults. Copyright © 2016 Elsevier GmbH. All rights reserved.

  18. Does Erythropoietin Cause Hemoglobin Variability- Is It ‘Normal’?

    Gupta, Ashwani K; David, Waseem

    2014-01-01

    Hemoglobin variability (Hb-var) in patients with chronic kidney disease has been stipulated to be a result of exogenous treatment with erythropoiesis stimulating agents (ESA) and has been related to mortality in dialysis patients. We hypothesized the existence of Hb-var independent of ESA administration and compared it to that in healthy adults using data from the Scripps-Kaiser and NHANES III databases. We studied the Hb-var in 1571 peritoneal dialysis patients which included 116 patients no...

  19. Optical Spectra of Hemoglobin Taken from Alcohol Dependent Humans

    Dudok K.; Dudok T.; Vlokh I.; Vlokh R.

    2005-01-01

    Optical spectra of CNMetHb and CNMetHb-Coomassi G-250, taken from the blood of humans with alcohol dependence, are studied in the spectral range of 450–750nm. The shifts in the spectral absorption maxima of CNMetHb-Coomassi G-250 complexes are observed for the diseased persons with alcohol dependence. The obtained results show that the hemoglobin structure of alcohol dependent humans is changed.

  20. Oxygenation properties and isoform diversity of snake hemoglobins

    Storz, Jay F.; Natarajan, Chandrasekhar; Moriyama, Hideaki

    2015-01-01

    Available data suggest that snake hemoglobins (Hbs) are characterized by a combination of unusual structural and functional properties relative to the Hbs of other amniote vertebrates, including oxygenation-linked tetramer- dimer dissociation. However, standardized comparative data are lacking fo...... isoform of the South American rattlesnake is homologous to the minor HbD of other amniotes and, contrary to the pattern of Hb isoform differentiation in birds and turtles, exhibits a lower O2 affinity than the HbA isoform....

  1. The Determinants of Hemoglobin Variability in Hemodialysis Patients

    Tomanoski Vasilije; Gjorgjievska Gordana; Zvezdakovska Jasminka; Krecova Vasiliki; Andonoski Aleksandar; Nakovska Margarita; Muharemi Serjat; Kliseski Tode; Janakievska Pavlina; Ristoska Katerina; Veliu Ramazan; Vasileva Liljana; Jovanov Toni; Mehmedi-Veseli Kaltrina; Ferati Beane

    2016-01-01

    Introduction. Factors that have been reported to affect erythropoietin (EPO) responsiveness in hemodialysis (HD) patients include iron deficiency, chronic inflammation, secondary hyperparathyroidism, malnutrition and inadequate HD dose. The aim of the study was to analyze the deteminants of hemoglobin variability in HD patients. Methods. The study encompassed 526 patients (197 F and 329 M). According to HD vintage at the beginning of the study the patients were divided into two groups: group-...

  2. Lower versus higher hemoglobin threshold for transfusion in septic shock.

    Holst, Lars B; Haase, Nicolai; Wetterslev, Jørn; Wernerman, Jan; Guttormsen, Anne B; Karlsson, Sari; Johansson, Pär I; Aneman, Anders; Vang, Marianne L; Winding, Robert; Nebrich, Lars; Nibro, Helle L; Rasmussen, Bodil S; Lauridsen, Johnny R M; Nielsen, Jane S; Oldner, Anders; Pettilä, Ville; Cronhjort, Maria B; Andersen, Lasse H; Pedersen, Ulf G; Reiter, Nanna; Wiis, Jørgen; White, Jonathan O; Russell, Lene; Thornberg, Klaus J; Hjortrup, Peter B; Müller, Rasmus G; Møller, Morten H; Steensen, Morten; Tjäder, Inga; Kilsand, Kristina; Odeberg-Wernerman, Suzanne; Sjøbø, Brit; Bundgaard, Helle; Thyø, Maria A; Lodahl, David; Mærkedahl, Rikke; Albeck, Carsten; Illum, Dorte; Kruse, Mary; Winkel, Per; Perner, Anders

    2014-10-09

    Blood transfusions are frequently given to patients with septic shock. However, the benefits and harms of different hemoglobin thresholds for transfusion have not been established. In this multicenter, parallel-group trial, we randomly assigned patients in the intensive care unit (ICU) who had septic shock and a hemoglobin concentration of 9 g per deciliter or less to receive 1 unit of leukoreduced red cells when the hemoglobin level was 7 g per deciliter or less (lower threshold) or when the level was 9 g per deciliter or less (higher threshold) during the ICU stay. The primary outcome measure was death by 90 days after randomization. We analyzed data from 998 of 1005 patients (99.3%) who underwent randomization. The two intervention groups had similar baseline characteristics. In the ICU, the lower-threshold group received a median of 1 unit of blood (interquartile range, 0 to 3) and the higher-threshold group received a median of 4 units (interquartile range, 2 to 7). At 90 days after randomization, 216 of 502 patients (43.0%) assigned to the lower-threshold group, as compared with 223 of 496 (45.0%) assigned to the higher-threshold group, had died (relative risk, 0.94; 95% confidence interval, 0.78 to 1.09; P=0.44). The results were similar in analyses adjusted for risk factors at baseline and in analyses of the per-protocol populations. The numbers of patients who had ischemic events, who had severe adverse reactions, and who required life support were similar in the two intervention groups. Among patients with septic shock, mortality at 90 days and rates of ischemic events and use of life support were similar among those assigned to blood transfusion at a higher hemoglobin threshold and those assigned to blood transfusion at a lower threshold; the latter group received fewer transfusions. (Funded by the Danish Strategic Research Council and others; TRISS ClinicalTrials.gov number, NCT01485315.).

  3. A retrospective study on fourteen year hemoglobin genotype ...

    This suggests the possibility of many other residents in the capital city of Ondo state carrying the abnormal forms of hemoglobin genotype, and calling for more efforts in the area of genetic counseling. The gene frequencies of A, S, and C were 0.91, 0.08 and 0.01, respectively. The prevalence of HbAA in this study has been ...

  4. Improvements in or relating to antibodies active against human hemoglobin Asub(1C)

    Javid, J.; Cerami, A.; Koenig, R.J.; Pettis, P.K.

    1980-01-01

    A method is described for preparing an antibody against human hemoglobin Asub(1c) which is substantially free of cross-reactivity against the human hemoglobins A 0 , Asub(1a) and Asub(1b). The antibodies are collected from cats, goats or sheep following injections of purified hemoglobin Asub(1c) antigen since these animals do not naturally produce hemoglobin Asub(1c). A radioimmunoassay method is also described whereby these antibodies are used to determine the quantity of hemoglobin Asub(1c) in blood samples. This is a useful technique in the diagnosis of diabetes mellitus. (U.K.)

  5. Concurrent measurement of cellular turbidity and hemoglobin to evaluate the antioxidant activity of plants.

    Bellik, Yuva; Iguer-Ouada, Mokrane

    2016-01-01

    In past decades, a multitude of analytical methods for measuring antioxidant activity of plant extracts has been developed. However, when using methods to determine hemoglobin released from human erythrocytes treated with ginger extracts, we found hemoglobin concentrations were significantly higher than in untreated control samples. This suggests in the presence of antioxidants that measuring hemoglobin alone is not sufficient to determine hemolysis. We show concurrent measurement of erythrocyte concentration and hemoglobin is essential in such assays, and describe a new protocol based on simultaneous measurement of cellular turbidity and hemoglobin. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Effect of ethanol of the radiation sensitivity of human hemoglobin

    Szweda-Lewandowska, Z.; Puchala, M.

    1981-01-01

    Radiation sensitivity of oxy-, deoxy-, and methemoglobin (HbOs, Hbbj, and MetHb) in water solutions containing 0.2 M ethanol and in ethanol-free solutions was compared. Radiation sensitivity was estimated on the basis of changes in absorbance at the Soret band (a = 430 nm for deoxyhemoglobin), changes in the absorbance ration Avqv/Avwt determined after conversion of irradiated preparations to methemoglobin, and changes in the value of parameters describing the reaction of hemoglobin oxygenation. The protection coefficient p of hemoglobin by ethanol (ratio of a change in the absence of ethanol to that in its presence) calculated from changes in absorbance at the Soret band equaled about 1.5 at a 4-Mrad dose in all bases except MetHb irradiated in air for which p was much higher (about 3.2). The protection coefficient p' calculated from Dtx values for changes in Avchemically bondv/Avwt equaled 2.2 for HbOs, and 2.8 for MetHb for preparations irradiated in air; p' = 1.7 for Hbbj and 1.8 for MetHb for preparations irradiated under argon. On the basis of these results, the role of /sup ./OH radicals and oxygen in the radiation damage of hemoglobin is discussed

  7. Hydrogen-tritium exchange survey of allosteric effects in hemoglobin

    Englander, J.J.; Englander, S.W.

    1987-01-01

    The oxy and deoxy forms of hemoglobin display major differences in H-exchange behavior. Hydrogen-tritium exchange experiments on hemoglobin were performed in the low-resolution mode to observe the dependence of these differences on pH (Bohr effect), organic phosphates, and salt. Unlike a prior report, increasing pH was found to decrease the oxy-deoxy difference monotonically, in general accordance with the alkaline Bohr effect. A prior report that the H-exchange difference between oxy- and deoxyhemoglobin vanishes at pH 9, and thus appears to reflect the Bohr effect alone, was found to be due to the borate buffer used, which at high pH tends to abolish the oxy-deoxy difference in a limited region of the H-exchange curve. Effects on hemoglobin H exchange due to organic phosphates parallel the differential binding of these agents (inositol hexaphosphate more than diphosphoglycerate, deoxy more than oxy, at low pH more than at high pH). Added salt slows H exchange of deoxyhemoglobin and has no effect on the oxy form. These results display the sensitivity of simple H-exchange measurements for finding and characterizing effects on structure and dynamics that may occur anywhere in the protein and help to define conditions for higher resolution approaches that can localize the changes observed

  8. Pitfalls in the biological diagnosis of common hemoglobin disorders.

    Wajcman, Henri; Moradkhani, Kamran

    2015-01-01

    In West-European countries, hemoglobin disorders are no more rare diseases. Programs for diagnosis of heterozygous carriers have been established to prevent cases with major sickle cell disease or thalassemias. These studies have been done essentially by high performance liquid chromatography on cation-exchange columns and electrophoresis (mostly capillary electrophoresis). They have been done through systematic population studies or premarital diagnosis. We describe in this work the frequent or rare pitfalls encountered, which led to false negative or positive diagnosis both in the field of sickle cell disease and thalassemias. In the absence of a well identified hemoglobin disorder in the proband's family, it is a rule that the use of a single test is insufficient to identify formally HbS. The presence of HbS could also be masked by another hemoglobin abnormality. The sole measurement of HbA2 level is insufficient to characterize a thalassemic trait: this level needs always to be interpreted considering RBC parameters and iron metabolic status. In difficult cases, the definitive answer may require a family study and/or a molecular genetic characterization.

  9. Carbon monoxide reduces near-infrared spectroscopy determined 'total' hemoglobin

    Niemann, Mads J; Sørensen, Henrik; Siebenmann, Christoph

    2017-01-01

    with CO (1.5 mL kg-1) was added to the circuit. Two NIRS systems (NIRO-200NX and INVOS-5100) assessed ScO2 as the ratio of oxygenated to deoxygenated hemoglobin, while venous blood samples were analyzed for carboxyhemoglobin (COHb). After CO/O2 rebreathing COHb increased to 8.7% (IQR; 7.9-9.4; p = .004...... to normoxia (68.9 ± 6.9%; p hemoglobin decreased (by 19.7 μM (median; IQR 2.8-34.8; p = .016) and 37.3 μM (30.8-46.6; p = .004), respectively) during inhalation of CO/O2 compared...... to inhalation of O2. Therefore, NIRO-200NX determined 'total' hemoglobin (sum of O2Hb and HHb) decreased (by 62.1 μM; 44.5-78.2; p = .001). In conclusion, exposure to CO did not increase MCAVmean, and neither NIRO-200NX nor INVOS-5100 detected a change in ScO2 when CO was added to inhalation of oxygen...

  10. Characterization of trypsin-derived peptides acrylamide-adducted hemoglobin

    Springer, D.L.; Goheen, S.C.; Edmonds, C.G.; McCulloch, M.; Sylvester, D.M.; Sander, C.; Bull, R.J.

    1991-01-01

    Even though there are a number of sources for human exposure to acrylamide, reliable biomarkers of exposure are not available. In an effort to develop such a biomarker, the authors are characterizing peptides derived from trypsin digests of acrylamide-adducted hemoglobin. For this, radiolabeled acrylamide was incubated with this, radiolabeled acrylamide was incubated with purified human hemoglobin (Ao) and decomposition products removed by dialysis. When the adducted hemoglobin was separated by reverse-phase HPLC, radioactivity eluted with the α and β subunits, suggesting covalent binding. Digestion of individual subunits with trypsin followed by reverse phase HPLC, indicated that most of the radioactivity associated with the α subunit co-eluted with a single peptide. Similar results were observed for the β subunit except that significant amounts of radioactivity eluted with the solvent front, suggesting that radioactivity was released by trypsin digestion. Currently, these preparation are under further characterization by electrospray ionization mass spectrometry. This approach will aid in the identification of the adducted will aid in the identification of the adducted peptide and subsequent preparation of an acrylamide-specific antibody

  11. A Comparative Case Study of Self-Actualization in Eleanor Roosevelt and Antoine de Saint-Exupery.

    Tyska, Cynthia Ann

    Eleanor Roosevelt and Antoine de Saint-Exupery are described as strongly developed self-actualizing people. They were selected as subjects of this study because they are generally believed to possess self-actualizing characteristics and because their positions as public figures made it more likely that data on them would be accessible.…

  12. 76 FR 555 - Keystone Holdings, LLC and Compagnie de Saint-Gobain; Analysis of Proposed Agreement Containing...

    2011-01-05

    ... Asia for a purchase price of $245 million. As originally structured, the assets acquired by Keystone... future, or that Saint-Gobain could sell the business upon terms that would reduce competition in the North American alumina wear tile markets. Therefore, the proposed Consent Agreement requires that...

  13. Scyllarides obtusus spec. nov., the scyllarid lobster of Saint Helena, Central South Atlantic (Crustacea: Decapoda Reptantia: Scyllaridae)

    Holthuis, L.B.

    1993-01-01

    A new species of slipper lobster is described from Saint Helena, where the species seems to be endemic. Known under the vernacular name Stump, the species forms the subject of a local fishery, carried out since early times. Previously the species has been identified with various Scyllarides species

  14. The Veneration and Visitation of the Graves of Saints in Soviet Central Asia. Insights from the Southern Ferghana Valley, Uzbekistan

    Exnerová, Věra

    2015-01-01

    Roč. 83, č. 3 (2015), s. 501-536 ISSN 0044-8699 R&D Projects: GA ČR(CZ) GA14-16520S Institutional support: RVO:68378009 Keywords : graves of saints * Uzbekistan * Ferghana Valley * Soviet period * oral history * local practices Subject RIV: AB - History

  15. 77 FR 15600 - Special Local Regulation; Emerald Coast Super Boat Grand Prix; Saint Andrew Bay; Panama City, FL

    2012-03-16

    ...-AA08 Special Local Regulation; Emerald Coast Super Boat Grand Prix; Saint Andrew Bay; Panama City, FL... navigable waters during the Emerald Coast Super Boat Grand Prix high speed boat races. Entry into... needed to safeguard persons and vessels from safety hazards associated with the Emerald Coast Super Boat...

  16. Geographic distribution of ebony leaf monkey Trachypithecus auratus (E. Geoffroy Saint-Hilaire, 1812) (Mammalia: Primates: Cercopithecidae)

    Nijman, Vincent

    2000-01-01

    As one of the fundamental units of ecology and biogeography, the geographic distribution of the endemic and threatened ebony leaf monkey Trachypithecus auratus (E. Geoffroy Saint-Hilaire, 1812) on the islands of Java, Bali, and Lombok (Indonesia) has been assessed. All localities where the species

  17. Une étude de cas. Saint Sébastien dans “Je suis sang” de Jan Fabre

    Lydie Toran

    2017-06-01

    Full Text Available Jan Fabre’s writing frequently displays a variety of quotations, especially visual ones. His 2001 Je suis sang (conte de fées médiéval is directly and indirectly inspired by Saint Sebastian’s iconography. This study examines the modalities and functions of this re-use in detail.

  18. Structural and functional properties of hemoglobins from unicellular organisms as revealed by resonance Raman spectroscopy.

    Egawa, Tsuyoshi; Yeh, Syun-Ru

    2005-01-01

    Hemoglobins have been discovered in organisms from virtually all kingdoms. Their presence in unicellular organisms suggests that the gene for hemoglobin is very ancient and that the hemoglobins must have functions other than oxygen transport, in view of the fact that O2 delivery is a diffusion-controlled process in these organisms. Based on sequence alignment, three groups of hemoglobins have been characterized in unicellular organisms. The group-one hemoglobins, termed truncated hemoglobins, consist of proteins with 110-140 amino acid residues and a novel two-over-two alpha-helical sandwich motif. The group-two hemoglobins, termed flavohemoglobins, consist of a hemoglobin domain, with a classical three-over-three alpha-helical sandwich motif, and a flavin-containing reductase domain that is covalently attached to it. The group-three hemoglobins consist of myoglobin-like proteins that have high sequence homology and structural similarity to the hemoglobin domain of flavohemoglobins. In this review, recent resonance Raman studies of each group of these proteins are presented. Their implications are discussed in the context of the structural and functional properties of these novel hemoglobins.

  19. A Proposed Community Network For Monitoring Volcanic Emissions In Saint Lucia, Lesser Antilles

    Joseph, E. P.; Beckles, D. M.; Robertson, R. E.; Latchman, J. L.; Edwards, S.

    2013-12-01

    Systematic geochemical monitoring of volcanic systems in the English-speaking islands of the Lesser Antilles was initiated by the UWI Seismic Research Centre (SRC) in 2000, as part of its volcanic surveillance programme for the English-speaking islands of the Lesser Antilles. This programme provided the first time-series observations used for the purpose of volcano monitoring in Dominica and Saint Lucia, permitted the characterization of the geothermal fluids associated with them, and established baseline studies for understanding of the hydrothermal systems during periods of quiescence (Joseph et al., 2011; Joseph et al., 2013). As part of efforts to improve and expand the capacity of SRC to provide volcanic surveillance through its geothermal monitoring programme, it is necessary to develop economically sustainable options for the monitoring of volcanic emissions/pollutants. Towards this effort we intend to work in collaboration with local authorities in Saint Lucia, to develop a monitoring network for quantifying the background exposure levels of ambient concentrations of volcanic pollutants, SO2 in air and As in waters (as health significant marker elements in the geothermal emissions) that would serve as a model for the emissions monitoring network for other volcanic islands. This programme would facilitate the building of local capacity and training to monitor the hazardous exposure, through the application and transfer of a regionally available low-cost and low-technology SO2 measurement/detection system in Saint Lucia. Existing monitoring technologies to inform evidence based health practices are too costly for small island Caribbean states, and no government policies or health services measures currently exist to address/mitigate these influences. Gases, aerosols and toxic elements from eruptive and non-eruptive volcanic activity are known to adversely affect human health and the environment (Baxter, 2000; Zhang et al., 2008). Investigations into the

  20. Fasting serum glucose and glycosylated hemoglobin level in obesity.

    Das, R K; Nessa, A; Hossain, M A; Siddiqui, N I; Hussain, M A

    2014-04-01

    Obesity is a condition in which the body fat stores are increased to an extent which impairs health and leads to serious health consequences. The amount of body fat is difficult to measure directly, and is usually determined from an indirect measure - the body mass index (BMI). Increased BMI in obese persons is directly associated with an increase in metabolic disease, such as type 2 diabetes mellitus. This Analytical cross sectional study was undertaken to assess the relation between obesity and glycemic control of body by measuring fasting serum glucose and glycosylated hemoglobin. This study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh from 1st July 2011 to 30th June 2012 on 120 equally divided male and female persons within the age range of 25 to 55 years. Age more than 55 years and less than 25 years and diagnosed case of Hypothyroidism, Cushing's syndrome, polycystic ovary, Antipsychotic drug user and regular steroid users were excluded. Non probability purposive type of sampling technique was used for selecting the study subjects. Measurement of body mass index was done as per procedure. Fasting serum glucose was estimated by glucose oxidase method and Glycosylated hemoglobin by Boronate Affinity method. Statistical analysis was done by SPSS (version 17.0). Data were expressed as Mean±SE and statistical significance of difference among the groups were calculated by unpaired student's 't' test and Pearson's correlation coefficient tests were done as applicable. The Mean±SE of fasting serum glucose was significant at 1% level (P value obese group of BMI. There was no significant difference of glycosylated hemoglobin level between control and study groups. But there was positive correlation within each group. Fasting serum glucose also showed a bit stronger positive correlation with BMI. Both obese male and female persons showed higher levels of fasting serum glucose and glycosylated hemoglobin. The observed positive

  1. Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species–pharmacokinetic and therapeutic implications

    Boretti, Felicitas S.; Baek, Jin Hyen; Palmer, Andre F.; Schaer, Dominik J.; Buehler, Paul W.

    2014-01-01

    Background: Haptoglobin (Hp) prevents hemoglobin (Hb) extravasation and attenuates Hb induced tissue oxidation and vasoconstriction. Small animal models such as mouse, rat and guinea pig appear to demonstrate proof-of-concept for Hb neutralization by Hp in diverse pre-clinical conditions. However, these species differ significantly from humans in the clearance of Hb:Hp and demonstrate long persistence of circulating Hb:Hp complexes. Objective: The focus of this study is to understand Hb:Hp...

  2. Hemoglobin redux: combining neutron and X-ray diffraction with mass spectrometry to analyse the quaternary state of oxidized hemoglobins

    Mueser, Timothy C., E-mail: timothy.mueser@utoledo.edu; Griffith, Wendell P. [Department of Chemistry, University of Toledo, Toledo, OH 43606 (United States); Kovalevsky, Andrey Y. [Bioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Guo, Jingshu; Seaver, Sean [Department of Chemistry, University of Toledo, Toledo, OH 43606 (United States); Langan, Paul [Department of Chemistry, University of Toledo, Toledo, OH 43606 (United States); Bioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Hanson, B. Leif [Department of Chemistry, University of Toledo, Toledo, OH 43606 (United States)

    2010-11-01

    X-ray and neutron diffraction studies of cyanomethemoglobin are being used to evaluate the structural waters within the dimer–dimer interface involved in quaternary-state transitions. Improvements in neutron diffraction instrumentation are affording the opportunity to re-examine the structures of vertebrate hemoglobins and to interrogate proton and solvent position changes between the different quaternary states of the protein. For hemoglobins of unknown primary sequence, structural studies of cyanomethemoglobin (CNmetHb) are being used to help to resolve sequence ambiguity in the mass spectra. These studies have also provided additional structural evidence for the involvement of oxidized hemoglobin in the process of erythrocyte senescence. X-ray crystal studies of Tibetan snow leopard CNmetHb have shown that this protein crystallizes in the B state, a structure with a more open dyad, which possibly has relevance to RBC band 3 protein binding and erythrocyte senescence. R-state equine CNmetHb crystal studies elaborate the solvent differences in the switch and hinge region compared with a human deoxyhemoglobin T-state neutron structure. Lastly, comparison of histidine protonation between the T and R state should enumerate the Bohr-effect protons.

  3. Egg deposition by lithophilic-spawning fishes in the Detroit and Saint Clair Rivers, 2005–14

    Prichard, Carson G.; Craig, Jaquelyn M.; Roseman, Edward F.; Fischer, Jason L.; Manny, Bruce A.; Kennedy, Gregory W.

    2017-03-14

    A long-term, multiseason, fish egg sampling program conducted annually on the Detroit (2005–14) and Saint Clair (2010–14) Rivers was summarized to identify where productive fish spawning habitat currently exists. Egg mats were placed on the river bottom during the spring and fall at historic spawning areas and candidate fish spawning habitat restoration sites throughout both rivers. Widespread evidence was found of lithophilic spawning by numerous native fish species, including walleye (Sander vitreus), lake whitefish (Coregonus clupeaformis), lake sturgeon (Acipenser fulvescens), suckers (Catostomidae spp.), and trout-perch (Percopsis omiscomaycus). Walleye, lake whitefish, and suckers spp. spawned in nearly every region of each river in all years on both reef and nonreef substrates. Lake sturgeon eggs were collected almost exclusively over constructed reefs. Catch-per-unit effort of walleye, lake whitefish, and sucker eggs was much greater in the Detroit River than in the Saint Clair River, while Saint Clair River sites supported the greatest collections of lake sturgeon eggs. Collections during this study of lake sturgeon eggs on man-made spawning reefs suggest that artificial reefs may be an effective tool for restoring fish populations in the Detroit and Saint Clair Rivers; however, the quick response of lake sturgeon to spawn on newly constructed reefs and the fact that walleye, lake whitefish, and sucker eggs were often collected over substrate with little interstitial space to protect eggs from siltation and predators suggests that lack of suitable spawning habitat may continue to limit reproduction of lithophilic-spawning fish species in the Saint Clair-Detroit River System.

  4. Resistance screening trials on coconut varieties to Cape Saint Paul Wilt Disease in Ghana

    Quaicoe Robert Nketsia

    2009-03-01

    Full Text Available The Cape Saint Paul Wilt Disease (CSPWD is a coconut lethal yellowing type disease (LY and is the single most serious threat to coconut cultivation in Ghana. The recommended disease management strategy is the cultivation of disease-resistant coconut varieties. More than 38 varieties have been screened for their resistance to CSPWD since 1956 and the results are reviewed in this paper. Two varieties, Sri Lanka Green Dwarf (SGD and Vanuatu Tall (VTT, have shown high resistance to the disease, and their hybrid (SGD × VTT is under observation to determine its performance. A programme to rehabilitate the CSPWD-devastated areas was started in 1999. Emerging results indicate that the MYD × VTT hybrid being used for the programme, succumbs to the disease under intense disease pressure. A redirection of the rehabilitation programme and the screening of more varieties are recommended.

  5. Saint-Quentin (Aisne, la collégiale et la crypte de la basilique

    Christian Sapin

    2005-10-01

    Full Text Available La courte campagne d’intervention fin juillet 2003, dans la crypte archéologique créée vers 1955 sous le sol du sanctuaire de la collégiale de Saint-Quentin, avait pour objet une meilleure compréhension des niveaux et des structures du haut Moyen Âge apparus lors des travaux des XIXe et XXe siècles. Un nettoyage complet, un plan et des relevés de maçonnerie sans nouvelle fouille, nous ont convaincu de l’important potentiel d’informations conservées. À partir de sondages anciens, il a été pos...

  6. Geothermic and thermal drilling in Saint-Paul-les-Dax - SPDX 1

    Godard, J.M.; Tronel, F.; Penicault, J.P.; Pouchan, P.

    1994-12-31

    In 1990, the municipality of Saint Paul les Dax (Landes), located in a thermal area, has decided to promote a geothermal-balneotherapy continued project. Geological studies and seismic exploration from oil and gas allowed to decide to drill a deep well on the northern flank of Dax diapir. The drilling operation (October - December 1993) has given the following result : final depth 1665 m, thermal reservoir dated Danian-Paleocene producing water at 66 degree celsius. The potential flowrate estimated at 150 m{sup 3}/h is going to be used to met the heating requirements of public buildings, greenhouses, collective equipment and new thermal centers. The geothermal use of the water will give annual energy saving of 5 900 MWh. (Authors). 2 figs.

  7. From Hillforts to Saints: Sun Tropoi and Patterns of Christianization in NW Spain

    Quintela, Marco V. García; García, A. César González; Veiga, Yolanda Seoane

    2015-05-01

    We present three Iron Age landscapes in the province of Ourense (northwest Spain), consisting of a hill fort with an acropolis used for religious purposes, and an "extra-urban" location used for ritual functions. Both locations are associated with the solstices, corroborating the validity of considering them jointly in each case, and the three cases jointly as a model. In the three locations, the oldest Christian saints and festivals we are able to identify re-use the dates of the solstices, and others, marked by Iron Age monuments. These observations open the way for research in several directions: the definition of religious landscapes from the Iron Age; the reason why there is not a 'Roman landscape'; the relationship between the Indo-European legacy and the introduction of Christianity; and the relationship between local calendars and the Celtic, Julian and Gregorian 'cultural' calendars.

  8. Life of saint Spiridon and history on relic to the bishop of Tremithus

    Adam Magruk

    2015-11-01

    Full Text Available In the last few years Saint Spyridon – the great hierarch of Greek Orthodox Church, is becoming increasingly known, glorified and praised by Orthodox Christians from all over the world including slavic territories. In Russia, for instance, St Spyridon is honored on a par with St Nikolaos the Wonderworker. Therefore, his biography is truly admirable, e.g. occurrences before the ordination to the priesthood and even more interestingly facts after he was made Bishop of Trimythous. St Spyridon participated in the sessions of the Firts Ecumenical Council, where he played a significant and remarkable role. Special attention deserve also the history of St Spyridon’s relics, which repose on the Greek island of Corfu to this day as well as his miraculous right hand returned to Orthodox Greeks by Catholic Church after c. 800 years.

  9. Results of the radiological survey at 14 Saint Ann Place, Rochelle Park, New Jersey (MJ032)

    Foley, R.D.; Floyd, L.M.

    1990-03-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally 232 Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 14 Saint Ann Place, Rochelle Park, New Jersey (MJ032), was conducted during 1987. 4 refs., 3 tabs

  10. The founder of the church of Saint George at Pološko

    Pavlović Dragana

    2015-01-01

    Full Text Available The paper seeks to establish who was the founder of the church of Saint George at Pološko and revise the conclusions of previous researchers regarding this issue. According to the opinion commonly adopted in the scholarly literature, Jovan Dragušin, a cousin of King Dušan, had merely undertaken the construction of church at Pološko, whereas his mother was responsible for the completion of construction and painting of frescoes in the church. Through an analysis of written and visual sources the conclusion is reached that the sole person responsible for the construction and painting of the church at Pološko was the nun Maria, the mother of Jovan Dragušin. [Projekat Ministarstva nauke Republike Srbije, br. 177036: Srpska srednjovekovna umetnost i njen evropski kontekst

  11. Cape Saint Paul Wilt Disease of coconut in Ghana: surveillance and management of disease spread

    Nkansah-Poku Joe

    2009-03-01

    Full Text Available The Cape Saint Paul Wilt Disease (CSPWD, a lethal-yellowing type disease of coconut has been in Ghana since 1932. Aerial and/or ground surveys were undertaken to assess the current status of the disease spread. The survey showed that the spread of the disease for the past 5 years has mainly been the expansion of existing foci. However, new outbreaks were identified at Glidzi in the Volta, Bawjiase and Efutu Breman in Central regions. After the resurgence in the Volta region in 1995, the Woe-Tegbi-Dzelukope corridor has remained endemic, but less aggressive. Pockets of healthy groves remain along all the coastline and inland of known disease zones. Eradication of diseased palms at Ampain focus lying just about 60 km to the Ivorian border, and disease situations on new replanting with MYD × VTT hybrid are discussed.

  12. Ecole d'été de probabilités de Saint-Flour XXXI

    2004-01-01

    This volume contains lectures given at the 31st Probability Summer School in Saint-Flour (July 8-25, 2001). Simon Tavaré’s lectures serve as an introduction to the coalescent, and to inference for ancestral processes in population genetics. The stochastic computation methods described include rejection methods, importance sampling, Markov chain Monte Carlo, and approximate Bayesian methods. Ofer Zeitouni’s course on "Random Walks in Random Environment" presents systematically the tools that have been introduced to study the model. A fairly complete description of available results in dimension 1 is given. For higher dimension, the basic techniques and a discussion of some of the available results are provided. The contribution also includes an updated annotated bibliography and suggestions for further reading. Olivier Catoni's course appears separately.

  13. Advice about the safety of graphite storage silos of Saint Laurent des Eaux facility

    2005-01-01

    This document is the safety analysis made by the national association of the local commissions of information about nuclear activities (ANCLI), about the safety of graphite storage silos of Saint Laurent des Eaux nuclear facility. The analysis covers: the operation safety and the accident hypothesis, the monitoring of indoor and outdoor contamination in routine situation, the geotechnical characteristics of the site environment, the isotopic inventory and the estimation of radioactivity in routine and accidental situation, the estimation of doses received by the population in accidental situation and the internal emergency plan. After examination of these different points, the scientific committee of the ANCLI considers that a new global evaluation of risks, which integrates more recent exposure data, has to be carried out. (J.S.)

  14. An Evolutionary Approach to Adaptive Capacity Assessment: A Case Study of Soufriere, Saint Lucia

    James Ryan Hogarth

    2016-03-01

    Full Text Available This paper assesses the capacity of Soufriere, Saint Lucia to adapt to climate change. A community-based vulnerability assessment was conducted that employed semi-structured interviews with community members. The results were analysed using the Local Adaptive Capacity (LAC framework, which characterises adaptive capacity based on five elements: asset base; institutions and entitlements; knowledge and information; innovation; and flexible forward-looking decision-making and governance. Beyond providing an in-depth analysis of Soufriere’s capacity to adapt to climate change, the paper argues that the elements of the LAC framework largely correspond with an evolutionary perspective on adaptive capacity. However, other evolutionary themes—such as structure, history, path-dependency, scale, agency, conservation of diversity, and the perils of specialisation—should also be taken into account.

  15. La collégiale de Saint-Bonnet-le-Château (Loire

    Bernard Ducouret

    2012-04-01

    Full Text Available La collégiale de Saint-Bonnet-le-Château est principalement connue pour les peintures murales du XVe siècle qui décorent sa chapelle basse, dont une partie est reproduite au musée des Monuments français, et, à un moindre degré, pour sa bibliothèque qui conserve de nombreux incunables. Son architecture, plus ignorée, n'en est pas moins digne d'intérêt. Nous ne présenterons pas ici l'ensemble de l'édifice, négligeant des éléments remarquables comme le porche sud (cf. plan, au-dessous de la sacr...

  16. La vision de Saint Eustathe dans la peinture post-byzantine

    Amprazogoula Katerina

    2008-01-01

    Full Text Available (francuski L'article étudie l'évolution de la Vision de saint Eustathe dans une série de peintures murales et d'icônes portatives - allant du XVIe au XVIIIe siècle - les formules iconographiques adoptées et leurs particularités ainsi que la place et la fonction de cette image dans la peinture murale. Le matériel étudié a montré une diversité de formules iconographiques qui exploitent pour l'essentiel la tradition byzantine et orientale du sujet, en manifestant en même temps ses propres traits ainsi que l'influence des images occidentales. .

  17. Farewell to Fiestas and Saints? Changing Catholic Practices in Contemporary Rural Oaxaca

    Toomas Gross

    2011-03-01

    Full Text Available This article discusses recent changes in Catholic festivities, especially the system of fiestas in rural Mexico. The ethnographic focus of the discussion is on indigenous Zapotec communities of the State of Oaxaca. Collective religious practices in Mexican villages contribute to social cohesion. Fiestas commemorating patron saints of the villages play a particularly important role in (reconstructing communal identity and the feeling of collective belongingness. Various global processes like secularisation, integration of local economies into the capitalist market system, increasing out-migration from villages, and the rise of Protestantism have undermined the position of the Catholic Church in the region. The article scrutinises the changing organisation and role of fiestas in the communities, concluding that the impact of secularisation, migration and Protestantism in particular is not simple and always negative – these changes can actually invigorate certain dimensions of the fiestas.

  18. Palaeontology of the upper Turonian paralic deposits of the Sainte-Mondane Formation, Aquitaine Basin, France

    Neraudenau, D.; Saint Martin, S.; Battern, D.J.; Colin, J.P.; Daviero-Gomez, V.; Girard, V.; Gomez, B.; Nohra, Y.A.; Polette, F.; Platel, J.P.; Saint Martin, J.P.; Vullo, R.

    2016-07-01

    The upper Turonian lignite deposits of Sainte-Mondane, Dordogne (Aquitaine Basin, SW France), consist of clays bearing translucent, orange to red, amber micrograins. The amber exhibits different types of microbial inclusions. The clays contain several conifers including the genera Brachyphyllum, Frenelopsis and Glenrosa, and a few leaf fragments of eudicot angiosperms. Among the plant meso-fossils the occurrence of Costatheca, Spermatites and abundant, diverse, megaspores, including species of Ariadnaesporites, Bacutriletes, Echitriletes, Erlansonisporites, Maexisporites, Minerisporites and Verrutriletes, is noteworthy. Pollen grains of the Normapolles group are important components of the palynomorph assemblage. The clays were deposited in a calm, estuarine or lagoonal, muddy environment. The overlying lignitic sands contain large fossil wood pieces of the conifer Agathoxylon, small solitary corals, fragmentary oysters and pectinids, echinoid spines, a few teeth of marine selachians and bony fishes, but no amber is present. These sands were deposited in a high-energy coastal marine environment. (Author)

  19. The facade of the church of Saint Spirit in Urbino: from scientific investigations to restoration

    Maria Letizia Amadori

    2003-02-01

    Full Text Available The state of advanced deterioration of the church of Saint Spirito of Urbino has induced the Superintendence for the Historical Artistic and Demoetnoanthropological Heritage of the Marches-Urbino and the Archiepiscopal Curia to program an intervention of restoration. Before that, the facade was covered from black crusts, grey deposits and yellowish films. The bricks of the wall, until to a height of approximately three meters from the bottom, moreover they were interested from processes of detachment, disintegration and exfoliation. In such area the presence of humidity was rather obvious and was attributable to phenomena of rising dump. In order to identify the constituent materials and to estimate of the state of conservation they have been carry out scientific investigations, whose it turns out have supplied profits indications for the restoration.

  20. L’enclos Saint-Césaire à Arles, un chantier controversé

    Marc Heijmans

    2010-03-01

    Full Text Available Contrairement à la plupart des sites présentés lors de ces journées à Luxeuil, le cas de la fouille de l’enclos Saint-Césaire d’Arles n’en est qu’à ses débuts, et rien ne garantit actuellement que le site sera un jour présenté, pour tout ou partie, au public. Sans vouloir dire que c’est un exemple à ne pas suivre, il montre la lente évolution d’un projet de rénovation où l’importance du patrimoine antique et médiéval n’a été que progressivement prise en compte. Cette contribution présente don...

  1. Risk behaviours and healthcare needs of homeless drug users in Saint Lucia and Trinidad.

    Day, Marcus; Devieux, Jessy G; Reid, Sandra D; Jones, Dionne J; Meharris, Joseph; Malow, Robert M

    2004-01-01

    In the Caribbean AIDS has become the leading cause of death among those aged 15-45. The homeless are at high risk due to the nexus of mobility, psychiatric disorders and substance use, particularly crack. Seventy-four homeless, out-of-treatment drug users were recruited in Saint Lucia and Trinidad to assess risk behaviour and healthcare needs. Information was collected in several domains: medical, mental health, substance use, sexual risk, and barriers to care. Ninety-five percent of the sample reported crack cocaine use within the previous 30 days. Approximately 35% of the sample had ever been diagnosed with a sexually transmitted disease and 25% of the sample reported being HIV+. Approximately 40% had a history of trading sex for crack or money. Due to the range of needs in this population, interventions should be multimodal. A focus on the individual, community, and structural levels is warranted to improve chances of program effectiveness.

  2. Chapel of cemetery church of all saints in Sedlec - Long-term analysis of hygrothermal conditions

    Pavlík, Zbyšek; Balík, Lukáš; Kudrnáčová, Lucie; Maděra, Jiří; Černý, Robert

    2017-07-01

    In this paper, long-term monitoring of hygrothermal conditions of the chapel of the cemetery church of All Saints in Sedlec, Czech Republic is presented as a practical tool for evaluation of functional problems of the researched structure. Within the performed experimental tests, interior and exterior climatic conditions were monitored over one year period. Herewith, surface temperature of the chapel wall was measured. Exterior climatic data were collected using weather station Vantage Pro2 placed in church tower. In interior, precise combined relative humidity/temperature sensors were installed. Based on the accessed hygrothermal state of the inspected chapel and identified periods of possible surface condensation, service conditions of the chapel will be optimized in order to prevent extensive damage of historically valuable finishing and furnishing materials, paintings, plasters, and architectural ornaments.

  3. Current hemoglobin levels are more predictive of disease progression than hemoglobin measured at baseline in patients receiving antiretroviral treatment for HIV type 1 infection

    Kowalska, Justyna D; Mocroft, Amanda; Blaxhult, Anders

    2007-01-01

    The role of hemoglobin levels as an independent prognostic marker of progression to AIDS and/or death in HIV-infected patients starting combination antiretroviral therapy (cART) was investigated. A total of 2,579 patients from the EuroSIDA cohort with hemoglobin, CD4 cell count, and HIV RNA viral...

  4. Translation to Spanish and Validation of the Specific Saint George's Questionnaire for Idiopathic Pulmonary Fibrosis.

    Capparelli, Ignacio; Fernandez, Martín; Saadia Otero, Marcela; Steimberg, Jimena; Brassesco, María; Campobasso, Ana; Palacios, Sandra; Caro, Fabian; Alberti, María Laura; Rabinovich, Roberto A; Paulin, Francisco

    2018-02-01

    Interstitial lung disease (ILD) is associated with low exercise tolerance, dyspnea, and decreased health-related quality of life (HRQL). Idiopathic pulmonary fibrosis (IPF) is one of the most prevalent in the group. A specific version of the Saint George's questionnaire (SGRQ-I) has been developed to quantify the HRQL of IPF patients. However, this tool is not currently validated in the Spanish language. The objective was to translate into Spanish and validate the specific Saint George's Respiratory Questionnaire for idiopathic pulmonary fibrosis (SGRQ-I). The repeatability, internal consistency and construct validity of the SGRQ-I in Spanish were analyzed after a backtranslation process. In total, 23 outpatients with IPF completed the translated SGRQ-I twice, 7 days apart. Repeatability was studied, revealing good concordance in test-retest with an ICC (interclass correlation coefficient) of 0.96 (P<.001). Internal consistency was good for different questionnaire items (Cronbach's alpha of 0.9 including and 0.81 excluding the total value) (P<.001). The total score of the questionnaire showed good correlation with forced vital capacity FVC% (r=-0.44; P=.033), diffusing capacity of the lungs for carbon monoxide (DL CO %) (r=-0.55; P=.011), partial pressure of oxygen in arterial blood PaO 2 (r=-0.44; P=.036), Medical Research Council Dyspnea scale (r=-0.65; P<.001), and number of steps taken in 24hours (r=-0.47; P=.024). The Spanish version of SGRQ-Ideveloped by our group shows good internal consistency, reproducibility and validity, so it can be used for the evaluation of quality of life (QOL) in IPF patients. Copyright © 2017 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.

  5. The religious tourism in Greece: Case study of Saint John Russian in N. Evia

    Aggeliki Chantziantoniou

    2017-12-01

    Full Text Available The prevailing political and economic conditions both in Greece and around the world determine the general development of all forms of tourism. The development of specific forms of tourism, such as that of religious tourism, gains tremendous interest in the present economic circumstances, as it is a factor in strengthening the national economy and at the same time a legacy for the future with enormous social, cultural and environmental significance. The development of a strategic approach to religious tourism can build on the comparative advantage of our country in this field by creating new tourist sites to attract tourists with intellectual pursuits and special interests. The Prefecture of Evia has a rich range of natural and cultural resources, with particular characteristics of beauty, uniqueness, and authenticity, elements that are required for the design and development of specific forms of tourism. In the case study on religious tourism in Saint John Russian in the Prefecture of Evia, an attempt is being made to explore the contribution of religious tourism tolocaldevelopmentandthepreconditionsforthepromotionofthepilgrimageof SaintJohn Russian to a major destination of religious and cultural interest of international scope. Additionally, an effort is made to highlight the importance of religious tourism as a special form of tourism that contributes to the development of areas hosting religious monuments. Identifying the opportunities and opportunities that exist, exploring its growth prospects and identifying emerging markets, dictates the formulation of policy proposals where combined with the existing specific forms of tourism it will show it as an essential factor in the systematic organization, exploitation and promotion of the Area.

  6. A Collaborative Approach to Monitoring Ambient Volcanogenic Pollution at Sulphur Springs, Saint Lucia.

    Joseph, E. P.; Beckles, D. M.; Cox, L.; Jackson, V. B.; Alexander, D.

    2015-12-01

    The role of volcano tourism is recognized as an important contributor to the economy of volcanic islands in the Lesser Antilles. However, if it is to be promoted as a sustainable sector of the tourism industry, visitors, tour operators, and vendors must be made aware of the potential health hazards facing them in volcanic environments. Volcanogenic air pollutants are of primary concern in this setting. In general, no warning signs, guidelines for recreational use, or emissions monitoring currently exists to provide warning to the public to decrease their vulnerability to the potential risks, or to minimize the liability of the agencies managing these areas. Sulphur Springs Park in Saint Lucia is a popular international destination, and concerns about the volcanic emissions and its possible health effect have been raised by visitors, staff, and management of the Park. As part of the responsibility of the UWI, Seismic Research Centre (SRC) to provide volcanic surveillance through its geothermal monitoring programme, a network was established for quantifying the ambient SO2 concentrations at Sulphur Springs in order to assess the potential risk of unsafe exposure. This effort required collaboration with the National Emergency Management Organization (NEMO) of Saint Lucia, as well as the staff and management of the Soufrière Regional Development Foundation (SRDF). Local personnel were trained in the active field sampling and analytical techniques required for the assessment of ambient SO2 concentrations over the monitoring period, thereby contributing to an active community-based effort. This type of approach was also thought to be an effective option for scientists to engage communities as partners in disaster risk reduction. Lessons learnt from this experience are presented for the benefit of other citizen monitoring projects, including its use as a tool for promoting volcanic hazard education, and enhancing communication and understanding between geoscientists and

  7. Saint Petersburg as a Global Coastal City: Positioning in the Baltic Region

    Lachininskii Stanislav

    2015-09-01

    Full Text Available The Baltic region consists of coastal areas of nine countries — Russia, Estonia, Latvia, Lithuania, Poland, Germany, Denmark, Sweden, and Finland. The region’s hubs are the port cities located along the Baltic Sea coast. However, Peter Taylor and Saskia Sassen’s classification identifies higher status cities and ‘global cities’, which are to be considered in the global context. Seven coastal regions are distinguished within this region, whose organising centers are the global coastal cities of Stockholm, Copenhagen, Helsinki, Riga, Tallinn, St. Petersburg, and Malmö. The concept of a “global city-region” (Sassen can be used as a methodological framework for analyzing this connection. Within this hierarchy, the dominant alpha group global city is Stockholm. The authors argue that, as a global coastal city, St. Petersburg forms the St. Petersburg coastal region, which can be defined as a typical "global city region". The index method shows that the position of St. Petersburg in the system of global coastal cities of the Baltic region is relatively favorable in view of its transport, logistics, and demographic potential and the advantageous geo-economic situation. St. Petersburg has certain competitive advantages in the region brought about by its demographic potential, port freight capacity, and the favorable geo-economic position of the "sea gate" of Russia. However, the level of high-tech services and ‘new economy’ development is not sufficient for the port to become a match for the top three cities (Stockholm, Helsinki, and Copenhagen. This is increasingly important because transboundary global city networks demonstrate that global cities are functions of global networks. Saint Petersburg is just starting to integrate into these networks through the Pulkovo airline hub and seaports of Ust-Luga, Primorsk, and Saint Petersburg.

  8. Saint Petersburg as a Global Coastal City: Positioning in the Baltic Region

    Lachninsky S.

    2015-08-01

    Full Text Available The Baltic region consists of coastal areas of nine countries — Russia, Estonia, Latvia, Lithuania, Poland, Germany, Denmark, Sweden, and Finland. The region’s hubs are the port cities located along the Baltic Sea coast. However, Peter Taylor and Saskia Sassen’s classification identifies higher status cities and ‘global cities’, which are to be considered in the global context. Seven coastal regions are distinguished within this region, whose organising centers are the global coastal cities of Stockholm, Copenhagen, Helsinki, Riga, Tallinn, St. Petersburg, and Malmö. The concept of a “global city-region” (Sassen can be used as a methodological framework for analyzing this connection. Within this hierarchy, the dominant alpha group global city is Stockholm. The authors argue that, as a global coastal city, St. Petersburg forms the St. Petersburg coastal region, which can be defined as a typical "global city region". The index method shows that the position of St. Petersburg in the system of global coastal cities of the Baltic region is relatively favorable in view of its transport, logistics, and demographic potential and the advantageous geo-economic situation. St. Petersburg has certain competitive advantages in the region brought about by its demographic potential, port freight capacity, and the favorable geo-economic position of the "sea gate" of Russia. However, the level of high-tech services and ‘new economy’ development is not sufficient for the port to become a match for the top three cities (Stockholm, Helsinki, and Copenhagen. This is increasingly important because transboundary global city networks demonstrate that global cities are functions of global networks. Saint Petersburg is just starting to integrate into these networks through the Pulkovo airline hub and seaports of Ust-Luga, Primorsk, and Saint Petersburg.

  9. Monitoring Persistent Volcanic Emissions from Sulphur Springs, Saint Lucia: A Community Approach to Disaster Risk Reduction

    Joseph, E. P.; Beckles, D. M.; Cox, L.; Jackson, V. B.; Alexander, D.

    2014-12-01

    Volcanic and geothermal emissions are known natural sources of volatiles to the atmosphere. Volcanogenic air pollutants known to cause the most serious impact are carbon dioxide (CO2), sulphur dioxide (SO2), hydrogen chloride (HCl) and hydrogen fluoride (HF). Some studies into the potential for volcanic emissions to produce chronic diseases in humans indicate that areas of major concern include respiratory problems, particularly silicosis (Allen et al. 2000; Baxter et al. 1999; Buist et al. 1986), psychological stress (Shore et al. 1986), and chemical impacts of gas or ash (Giammanco et al. 1998). Sulphur Springs Park in Saint Lucia has a very high recreational value with >200,000 visitors annually, while the nearby town of Soufrière has >8,400 residents. Residents and visitors have raised concerns about the volcanic emissions and its health effects. As part of the volcanic surveillance programme undertaken by the UWI, Seismic Research Centre (SRC) in Saint Lucia, a new monitoring network has been established for quantifying the ambient SO2 in air, to which staff and visitors at the volcanic park are exposed to. The implementation and continued operation of this network has involved the training of local personnel in the active field sampling and analytical techniques required for the assessment of ambient SO2 concentrations, using a low cost monitor as well as commercial passive samplers. This approach recognizes that environmental hazards are a usual part of life and productive livelihoods, and to minimize post-disaster response and recovery it is beneficial to promote preparedness and mitigation, which is best achieved at the local level with community involvement. It is also intended that the volcanic emissions monitoring network could be used as a method to establish and maintain community-based initiatives that would also be helpful when volcanic threat manifests.

  10. Clinical, hematological and genetic data of a cohort of children with hemoglobin SD

    Paulo do Val Rezende

    Full Text Available ABSTRACT INTRODUCTION: The hemoglobin FSD is very uncommon in newborn screening programs for sickle cell disease. In the program of Minas Gerais, Brazil, the clinical course of children with hemoglobin SD was observed to be heterogeneous. The objective of this study was to estimate the incidence (1999-2012 and to describe the natural history of a cohort of newborns with hemoglobin SD. METHODS: Isoelectric focusing was the primary method used in newborn screening. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing were used to identify mutant alleles and for haplotyping. Gap-polymerase chain reaction was used to detect alpha-thalassemia. RESULTS: Eleven cases of hemoglobin S/D-Punjab and eight of Hb S-Korle Bu were detected. Other variants with hemoglobin D mobility were not identified. All hemoglobin D-Punjab and hemoglobin Korle Bu alleles were associated with haplotype I. Among the children with hemoglobin S/D-Punjab, there were four with the ßS CAR haplotype, six with the Benin haplotype, and one atypical. Results of laboratory tests for hemoglobin S/D-Punjab and hemoglobin S-Korle Bu were: hemoglobin 8.0 and 12.3 g/dL (p-value <0.001, leukocyte count 13.9 × 109/L and 10.5 × 109/L (p-value = 0.003, reticulocytes 7.5% and 1.0% (p-value <0.001, hemoglobin F concentration 16.1% and 6.9% (p-value = 0.001 and oxygen saturation 91.9% and 97% (p-value = 0.002, respectively. Only hemoglobin S/D-Punjab children had acute pain crises and needed blood transfusions or hydroxyurea. Those with the Benin ßS haplotype had higher total hemoglobin and hemoglobin F concentrations compared to the CAR haplotype. Transcranial Doppler was normal in all children. CONCLUSION: The clinical course and blood cell counts of children with hemoglobin S/D-Punjab were very similar to those of hemoglobin SS children. In contrast, children with hemoglobin S-Korle Bu had clinical course and blood cell counts like children with the sickle

  11. Structure and stability of human hemoglobin microparticles prepared with a double emulsion technique.

    Cedrati, N; Bonneaux, F; Labrude, P; Maincent, P

    1997-09-01

    Hemoglobin solutions can be used as blood substitutes but they present some disadvantages often due to their rapid removal from the bloodstream after injection. A possible way of overcoming this problem is to trap hemoglobin inside particles. This study deals with the preparation, structure and stability of poly(lactic acid) and ethylcellulose microparticles containing human hemoglobin obtained with a double emulsion technique. We investigated the manufacturing process of these particles in order to increase the encapsulation ratio of hemoglobin. For this purpose, some parameters involved in the procedure were optimized, such as hemoglobin concentration and duration of stirring: hemoglobin loading increases with its concentration in the preparation and well-defined stirring time avoids a leakage of hemoglobin. Hemoglobin concentration, surfactant concentration i.e. poly(vinylic alcohol), amounts of polymer and solvent (methylene chloride), duration and speed of stirring. The microparticles were prepared with satisfactory yields (60 to 73%). They were spherical and their mean size was lower than 200 microns. The functional properties of entrapped hemoglobin were studied. The encapsulation did not alter hemoglobin and the oxygen affinity of the hemoglobin remained unmodified (P50 about 13.9 mm Hg in a Bis-Tris buffer pH 7.4 at 37 degrees C). Moreover, only low levels of methemoglobin could be detected (less than 3%). Besides, about 90% of encapsulated hemoglobin could be released from microparticles, with a speed related to the internal structure of the particles. The prepared microparticles were stored during one month at +4 degrees C. No degradation of the particle structure occurred and the functional properties of hemoglobin were preserved. These particles could provide a potential source of oxygen in the field of biotechnologies but any application for a transfusional purpose would first require a drastic reduction in particle size.

  12. Alimentación y consumo no cárnico en el Solutrense cantábrico: mandíbulas y falanges fracturadas intencionalmente en el nivel 9 de la Cueva de Las Caldas (Priorio, Oviedo

    Ana MATEOS CACHORRO

    2009-12-01

    Full Text Available RESUMEN: LOS grupos humanos que habitaron la cueva de Las Caldas en torno al 19.000 BP fracturaron todos los elementos esqueléticos, incluso las mandíbulas y falanges, última reserva de grasa en un animal. En este análisis se trata de caracterizar las pautas de fracturación en estos restos óseos dentro del conjunto del procesado antrópico y de verificar la fractura diferencial como respuesta a una estrategia de subsistencia y consumo maximal.ABSTRACT: The human groups who lived in Caldas cave about 19.000 BP fractured all skeletal elements even mandibles and phalanges, the last fat reserve in animáis. Therefore it will be caracterized their fracturing patterns on some specific bones in the ensemble of human processing and it will be verified probably diferential fracturing as response to subsistence strategie and maximal eating habit.

  13. Effects of hydroxyurea treatment for patients with hemoglobin SC disease.

    Luchtman-Jones, Lori; Pressel, Sara; Hilliard, Lee; Brown, R Clark; Smith, Mary G; Thompson, Alexis A; Lee, Margaret T; Rothman, Jennifer; Rogers, Zora R; Owen, William; Imran, Hamayun; Thornburg, Courtney; Kwiatkowski, Janet L; Aygun, Banu; Nelson, Stephen; Roberts, Carla; Gauger, Cynthia; Piccone, Connie; Kalfa, Theodosia; Alvarez, Ofelia; Hassell, Kathryn; Davis, Barry R; Ware, Russell E

    2016-02-01

    Although hemoglobin SC (HbSC) disease is usually considered less severe than sickle cell anemia (SCA), which includes HbSS and HbS/β(0) -thalassemia genotypes, many patients with HbSC experience severe disease complications, including vaso-occlusive pain, acute chest syndrome, avascular necrosis, retinopathy, and poor quality of life. Fully 20 years after the clinical and laboratory efficacy of hydroxyurea was proven in adult SCA patients, the safety and utility of hydroxyurea treatment for HbSC patients remain unclear. Recent NHLBI evidence-based guidelines highlight this as a critical knowledge gap, noting HbSC accounts for ∼30% of sickle cell patients within the United States. To date, only 5 publications have reported short-term, incomplete, or conflicting laboratory and clinical outcomes of hydroxyurea treatment in a total of 71 adults and children with HbSC. We now report on a cohort of 133 adult and pediatric HbSC patients who received hydroxyurea, typically for recurrent vaso-occlusive pain. Hydroxyurea treatment was associated with a stable hemoglobin concentration; increased fetal hemoglobin (HbF) and mean corpuscular volume (MCV); and reduced white blood cell count (WBC), absolute neutrophil count (ANC), and absolute reticulocyte count (ARC). Reversible cytopenias occurred in 22% of patients, primarily neutropenia and thrombocytopenia. Painful events were reduced with hydroxyurea, more in patients >15 years old. These multicenter data support the safety and potentially salutary effects of hydroxyurea treatment for HbSC disease; however, a multicenter, placebo-controlled, Phase 3 clinical trial is needed to determine if hydroxyurea therapy has efficacy for patients with HbSC disease. © 2015 Wiley Periodicals, Inc.

  14. Spectroscopic markers of the TR quaternary transition in human hemoglobin.

    Schirò, Giorgio; Cammarata, Marco; Levantino, Matteo; Cupane, Antonio

    2005-04-01

    In this work, we use a sol-gel protocol to trap and compare the R and T quaternary states of both the deoxygenated (deoxyHb) and carbonmonoxide (HbCO) derivatives of human hemoglobin. The near infrared optical absorption band III and the infrared CO stretching band are used to detect the effect of quaternary structure on the spectral properties of deoxyHb and HbCO; comparison with myoglobin allows for an assessment of tertiary and quaternary contributions to the measured band shifts. The RT transition is shown to cause a blue shift of the band III by approximately 35 cm(-1) for deoxyHb and a red shift of the CO stretching band by only approximately 0.3 cm(-1) for HbCO. This clearly shows that quaternary structure changes are transmitted to the heme pocket and that effects on deoxyHb are much larger than on HbCO, at least as far as the band energies are concerned. Experiments performed in the ample temperature interval of 300-10K show that the above quaternary structure effects are "static" and do not influence the dynamic properties of the heme pocket, at least as probed by the temperature dependence of band III and of the CO stretching band. The availability of quaternary structure sensitive spectroscopic markers and the quantitative measurement of the quaternary structure contribution to band shifts will be of considerable help in the analysis of flash-photolysis experiments on hemoglobin. Moreover, it will enable one to characterize the dynamic properties of functionally relevant hemoglobin intermediates and to study the kinetics of both the T-->R and R-->T quaternary transitions through time-resolved spectroscopy.

  15. Subluxação da mandíbula para abordagem de bifurcação carotídea alta em paciente com parotidite por contraste iodado: relato de caso e revisão de literatura

    Reinaldo Benevides dos Santos

    2017-11-01

    Full Text Available Resumo A doença aterosclerótica das carótidas extracranianas pode resultar em complicações com alta morbidade e mortalidade. A avaliação pré-operatória com exames contrastados de imagem é associada a complicações como a parotidite, além das já bem conhecidas reações alérgicas e da disfunção renal. A bifurcação carotídea alta e a doença aterosclerótica de extensão cranial costumam ser fatores limitantes para o tratamento cirúrgico convencional. Entretanto, quando há contraindicação ao uso de contraste iodado ou impossibilidade do tratamento endovascular, há a necessidade do conhecimento de técnicas cirúrgicas que permitam a realização da endarterectomia com segurança. A subluxação da mandíbula se mostrou uma técnica adjuvante segura e efetiva, de fácil execução e reprodutibilidade, possibilitando o acesso a bifurcações carotídeas altas com boa exposição do campo cirúrgico e permitindo a realização da endarterectomia conforme a técnica padrão. Apresentamos o caso de uma paciente com bifurcação carotídea alta e com limitações para uso do contraste iodado que foi submetida a endarterectomia carotídea após subluxação de mandíbula.

  16. Synthesis of iron nanoparticles from hemoglobin and myoglobin

    Sayyad, Arshad S; Ajayan, Pulickel M; Balakrishnan, Kaushik; Ci, Lijie; Kabbani, Ahmad T; Vajtai, Robert

    2012-01-01

    Stable iron nanoparticles have been synthesized from naturally occurring and abundant Fe-containing bio-precursors, namely hemoglobin and myoglobin. The formation of stable iron nanoparticles was achieved through a one-pot, single-phase chemical reduction approach. The reduction of iron ions present in the bio-precursors was carried out at room temperature and avoids the use of harsh chemical reagents. The size distribution of the product falls into the narrow 2–5 nm range and the particles were found to be crystalline. This method can be a valuable synthetic approach for producing bio-conjugated nanoparticle systems for biological applications. (paper)

  17. The Correlation of Hemoglobin A1c to Blood Glucose

    Sikaris, Ken

    2009-01-01

    The understanding that hemoglobin A1c (HbA1c) represents the average blood glucose level of patients over the previous 120 days underlies the current management of diabetes. Even in making such a statement, we speak of “average blood glucose” as though “blood glucose” were itself a simple idea. When we consider all the blood glucose forms—arterial versus venous versus capillary, whole blood versus serum versus fluoride-preserved plasma, fasting versus nonfasting—we can start to see that this ...

  18. Optoacoustic monitoring of blood hemoglobin concentration: a pilot clinical study

    Petrova, Irina Y.; Esenaliev, Rinat O.; Petrov, Yuriy Y.; Brecht, Hans-Peter F.; Svensen, Christer H.; Olsson, Joel; Deyo, Donald J.; Prough, Donald S.

    2005-07-01

    The optoacoustic technique is noninvasive, has high spatial resolution, and potentially can be used to measure the total hemoglobin concentration ([THb]) continuously and accurately. We performed in vitro measurements in blood and in vivo tests in healthy volunteers. Our clinical protocol included rapid infusion of intravenous saline to simulate rapid change in the [THb] during fluid therapy or surgery. Optoacoustic measurements were made from the wrist area overlying the radial artery for more than 1 h. The amplitude of the optoacoustic signal generated in the radial artery closely followed the [THb] measured directly in concurrently collected blood samples.

  19. Moessbauer studies of hemoglobin in high altitude polycythemia

    Zhang Xiufang; Shen Linming; Chen Songsen; Ao Zhaohui; Liu Yuanyuan; Gao Naifei; Zheng Yuanming; Shong Liangquan

    1990-01-01

    The Moessbauer spectra have been measured in erythrocytes from normal adults and the patients with high altitude polycythemia (HAPC). The results indicated that two subspectra ''a'' and ''b'', corresponding to oxy- and deoxyhemoglobin respectively, were present in all blood samples, and a third subspectrum ''c'' was found to exist in almost all samples from the patients. The parameters of the third subspectra ''c1'' in most samples from the patients were similar to those of carbon monoxyhemoglobin. The components were considered to be the denatured hemoglobin in RBCs (red blood cells). Together with clinical analysis, a possible mechanism of HAPC has been discussed. (orig.)

  20. Mössbauer studies of hemoglobin in high altitude polycythemia

    Xiufang, Zhang; Linming, Shen; Songsen, Chen; Yuanyuan, Liu; Naifei, Gao; Yuanming, Zheng; Zhaohui, Ao; Liangquan, Shong

    1990-07-01

    The Mössbauer spectra have been measured in erythrocytes from normal adults and the patients with high altitude polycythemia (HAPC). The results indicated that two subspectra “a” and “b”, corresponding to oxy- and deoxyhemoglobin respectively, were present in all blood samples, and a third subspectrum “c” was found to exist in almost all samples from the patients. The parameters of the third subspectra “cl” in most samples from the patients were similar to those of carbon monoxyhemoglobin. The components were considered to be the denatured hemoglobin in RBCs (red blood cells). Together with clinical analysis, a possible mechanism of HAPC has been discussed.

  1. Molecular and cellular pathogenesis of hemoglobin SC disease.

    Bunn, H F; Noguchi, C T; Hofrichter, J; Schechter, G P; Schechter, A N; Eaton, W A

    1982-01-01

    Solution and cell studies were performed to ascertain why individuals with hemoglobin (Hb) SC have disease whereas those with Hb AS do not. The polymerization of deoxygenated mixtures containing sickle cell Hb (Hb S; alpha 2 beta 2(6)Glu leads to Val) and Hb C (alpha 2 beta 2(6)Glu leads to Lys) was investigated by measurements of delay times and solubilities. In mixtures containing more than 40% Hb S, polymerization takes place by the same mechanism as in solutions of Hb S alone, with no evi...

  2. Síntese e caracterização de um novo composto obtido pela reação entre hidreto de trifenilestanho e ácido (±)-mandélico e avaliação de seu potencial biocida sobre o fungo Fusarium oxysporum f. sp. cubense Synthesis, characterization and evaluation of the biocide effect on the fungus Fusarium oxysporum f. sp. cubense of a new compound obtained by reaction of triphenyltin hydride and (±)-mandelic acid

    Roberto Santos Barbiéri; Elysio Prado de Lima; Samuel Ferreira da Silva; Allan Kardec Carlos Dias; Maria das Graças Cardoso; Vilma Reis Terra

    2006-01-01

    O presente artigo refere-se à síntese e caracterização de um novo composto organoestânico, pela reação de ácido (±)-mandélico e hidreto de trifenilestanho, em meio de acetonitrila e sob refluxo, [(C6H5)2SnMand 2] {Mand = C6H5CH(OH)COO], identificado por análise elementar de carbono e hidrogênio, espectroscopia no infravermelho e espectrometria de massa de alta resolução, para o qual foi proposta estrutura octaédrica com o grupo fenila em posição trans. Verificou-se que o composto apresenta aç...

  3. Modeling hemoglobin at optical frequency using the unconditionally stable fundamental ADI-FDTD method.

    Heh, Ding Yu; Tan, Eng Leong

    2011-04-12

    This paper presents the modeling of hemoglobin at optical frequency (250 nm - 1000 nm) using the unconditionally stable fundamental alternating-direction-implicit finite-difference time-domain (FADI-FDTD) method. An accurate model based on complex conjugate pole-residue pairs is proposed to model the complex permittivity of hemoglobin at optical frequency. Two hemoglobin concentrations at 15 g/dL and 33 g/dL are considered. The model is then incorporated into the FADI-FDTD method for solving electromagnetic problems involving interaction of light with hemoglobin. The computation of transmission and reflection coefficients of a half space hemoglobin medium using the FADI-FDTD validates the accuracy of our model and method. The specific absorption rate (SAR) distribution of human capillary at optical frequency is also shown. While maintaining accuracy, the unconditionally stable FADI-FDTD method exhibits high efficiency in modeling hemoglobin.

  4. Heterozygote Hemoglobin G-Coushatta as the Cause of a Falsely Decreased Hemoglobin A1C in an Ion-Exchange HPLC Method

    Kurtoğlu Ayşegül Uğur

    2017-09-01

    Full Text Available Glycated hemoglobin (HbA1c is used for the assessment of glycemic control in patients with diabetes. The presence of genetic variants of hemoglobin can profoundly affect the accuracy of HbA1c measurement. Here, we report two cases of Hemoglobin G-Coushatta (HBB:c.68A>C variant that interferes in the measurement of HbA1c by a cation-exchange HPLC (CE-HPLC method. HbA1c was measured by a CE-HPLC method in a Tosoh HLC-723 G7 instrument. The HbA1c levels were 2.9% and 4%. These results alerted us to a possible presence of hemoglobinopathy. In the hemoglobin variant analysis, HbA2 levels were detected as 78.3% and 40.7% by HPLC using the short program for the Biorad Variant II. HbA1c levels were measured by an immunoturbidimetric assay in a Siemens Dimension instrument. HbA1c levels were reported as 5.5% and 5.3%. DNA mutation analysis was performed to detect the abnormal hemoglobin variant. Presence of Hemoglobin G-Coushatta variant was detected in the patients. The Hb G-Coushatta variants have an impact on the determination of glycated hemoglobin levels using CEHPLC resulting in a false low value. Therefore, it is necessary to use another measurement method.

  5. Genetic and developmental variation of hemoglobin in the deermouse, Peromyscus maniculatus.

    Maybank, K M; Dawson, W D

    1976-04-01

    A genetic investigation of electrophoretic hemoglobin variants of the deermouse, Peromyscus maniculatus, shows three alleles, Hblf, Hblr, and Hblo, at a duplicated site controlling the six adult phenotypes. The Hblf allele has not been described previously. The hemoglobin locus is not closely linked to the albino locus. Fetal hemoglobin is distinct from any of the adult components and has a slower electrophoretic mobility. The fetal phenotype changes to the adult type between the days 15 and 18 of prenatal life.

  6. Quantitative analysis of composition, structure and features of hemoglobin under the influence of radiation in vivo

    Kurbanov, F.F.; Mamedov, T.G.; Abdullaev, Kh.D.; Akhmedov, N.A.; Manojlov, S.K.

    1995-01-01

    The literature data on the changes in composition, structure and properties of hemoglobin under the influence of ionizing radiation in vivo are reviewed. The algorithm of calculation of damaged hemoglobin molecule percentage is proposed. Four main realizations of radiation-chemical damage are considered. By the algorithm the estimation of the damaged molecules percentage resulted from the exposure to 10 Gy is given. Hemoglobin radiation damage is considered as one of the most important mechanisms triggering radiation sickness. 11 refs

  7. Structure of Greyhound hemoglobin: origin of high oxygen affinity.

    Bhatt, Veer S; Zaldívar-López, Sara; Harris, David R; Couto, C Guillermo; Wang, Peng G; Palmer, Andre F

    2011-05-01

    This study presents the crystal structure of Greyhound hemoglobin (GrHb) determined to 1.9 Å resolution. GrHb was found to crystallize with an α₁β₁ dimer in the asymmetric unit and belongs to the R2 state. Oxygen-affinity measurements combined with the fact that GrHb crystallizes in the R2 state despite the high-salt conditions used for crystallization strongly indicate that GrHb can serve as a model high-oxygen-affinity hemoglobin (Hb) for higher mammals, especially humans. Structural analysis of GrHb and its comparison with the R2-state of human Hb revealed several regions that can potentially contribute to the high oxygen affinity of GrHb and serve to rationalize the additional stability of the R2-state of GrHb. A previously well studied hydrophobic cluster of bar-headed goose Hb near α119 was also incorporated in the comparison between GrHb and human Hb. Finally, a structural comparison with generic dog Hb and maned wolf Hb was conducted, revealing that in contrast to GrHb these structures belong to the R state of Hb and raising the intriguing possibility of an additional allosteric factor co-purifying with GrHb that can modulate its quaternary structure.

  8. [Hemoglobin and testosterone: importance on high altitude acclimatization and adaptation].

    Gonzales, Gustavo F

    2011-03-01

    The different types of response mechanisms that the organism uses when exposed to hypoxia include accommodation, acclimatization and adaptation. Accommodation is the initial response to acute exposure to high altitude hypoxia and is characterized by an increase in ventilation and heart rate. Acclimatization is observed in individuals temporarily exposed to high altitude, and to some extent, it enables them to tolerate the high altitudes. In this phase, erythropoiesis is increased, resulting in higher hemoglobin and hematocrit levels to improve oxygen delivery capacity. Adaptation is the process of natural acclimatization where genetical variations and acclimatization play a role in allowing subjects to live without any difficulties at high altitudes. Testosterone is a hormone that regulates erythropoiesis and ventilation and could be associated to the processes of acclimatization and adaptation to high altitude. Excessive erythrocytosis, which leads to chronic mountain sickness, is caused by low arterial oxygen saturation, ventilatory inefficiency and reduced ventilatory response to hypoxia. Testosterone increases during acute exposure to high altitude and also in natives at high altitude with excessive erythrocytosis. Results of current research allow us to conclude that increase in serum testosterone and hemoglobin is adequate for acclimatization, as they improve oxygen transport, but not for high altitude adaptation, since high serum testosterone levels are associated to excessive erythrocytosis.

  9. Hemoglobinas anormais e dificuldade diagnóstica Abnormal hemoglobins

    Guilherme G. Leoneli

    2000-12-01

    Full Text Available As hemoglobinas humanas, com padrão de herança definido geneticamente, apresentam variações polimórficas características dentro de nossa população, na dependência dos grupos raciais que formam cada região. Aparecem sob a forma de variantes de hemoglobinas ou talassemias, sendo mais freqüentes, no Brasil, os tipos variantes S e C e as talassemias alfa e beta, todas na forma heterozigota. Durante o ano de 1999, amostras de sangue de 506 indivíduos com anemia a esclarecer ou que já passaram por alguma triagem de hemoglobinopatias foram encaminhadas ao Centro de Referência de Hemoglobinas da UNESP, para confirmação diagnóstica e submetidas a procedimentos eletroforéticos, análises bioquímicas e citológicas, para caracterização das hemoglobinas anormais. O objetivo do presente estudo foi verificar quais tipos de hemoglobinas anormais apresentam maior dificuldade diagnóstica. As amostras foram provenientes de 24 cidades de doze estados. Os resultados mostraram que 354 indivíduos (69,96% apresentaram hemoglobinas anormais, sendo 30 Hb AS (5,93%, 5 Hb AC (0,98%, 76 sugestivos de talassemia alfa heterozigota (15,02%, 134 sugestivos de talassemia beta heterozigota (26,48% e 109 com outras formas de hemoglobinas anormais (21,54%, que incluem variantes raras e interações de diferentes formas de talassemias e hemoglobinas variantes. Concluiu-se que, apesar da melhoria técnica oferecida atualmente e a constante formação de recursos humanos capacitados, as talassemias em sua forma heterozigota (210 indivíduos -- 41,50% são responsáveis pela maior dificuldade diagnóstica, seguido da caracterização de variantes raras e formas interativas de hemoglobinopatias (109 indivíduos -- 21,54%, sugerindo que se deve aumentar a capacidade de formação de pessoal e as informações a respeito destas alterações genéticas em nossa população.The human hemoglobins, with genetically defined inheritance patterns, have shown

  10. Thalassemia and Hemoglobin E in Southern Thai Blood Donors

    Manit Nuinoon

    2014-01-01

    Full Text Available Thalassemia and hemoglobin E (Hb E are common in Thailand. Individuals with thalassemia trait usually have a normal hemoglobin concentration or mild anemia. Therefore, thalassemic individuals who have minimum acceptable Hb level may be accepted as blood donors. This study was aimed at determining the frequency of α-thalassemia 1 trait, β-thalassemia trait, and Hb E-related syndromes in Southern Thai blood donors. One hundred and sixteen voluntary blood donors, Southern Thailand origin, were recruited for thalassemia and Hb E screening by red blood cell indices/dichlorophenolindophenol precipitation test. β-Thalassemia and Hb E were then identified by high performance liquid chromatography and 4 common α-thalassemia deletions were characterized by a single tube-multiplex gap-polymerase chain reaction. Overall frequency of hemoglobinopathies was 12.9%, classified as follows: homozygous α-thalassemia 2 (1.7%, heterozygous α-thalassemia 1 (1.7%, heterozygous β-thalassemia without α-thalassemia (0.9%, heterozygous Hb E without α-thalassemia (5.2%, double heterozygotes for Hb E/α-thalassemia 1 (1.7%, homozygous Hb E without α-thalassemia (0.9%, and homozygous Hb E with heterozygous α-thalassemia 2 (0.9%. The usefulness of thalassemia screening is not only for receiving highly effective red blood cells in the recipients but also for encouraging the control and prevention program of thalassemia in blood donors.

  11. Biphasic oxidation of oxy-hemoglobin in bloodstains.

    Rolf H Bremmer

    Full Text Available BACKGROUND: In forensic science, age determination of bloodstains can be crucial in reconstructing crimes. Upon exiting the body, bloodstains transit from bright red to dark brown, which is attributed to oxidation of oxy-hemoglobin (HbO(2 to met-hemoglobin (met-Hb and hemichrome (HC. The fractions of HbO(2, met-Hb and HC in a bloodstain can be used for age determination of bloodstains. In this study, we further analyze the conversion of HbO(2 to met-Hb and HC, and determine the effect of temperature and humidity on the conversion rates. METHODOLOGY: The fractions of HbO(2, met-Hb and HC in a bloodstain, as determined by quantitative analysis of optical reflectance spectra (450-800 nm, were measured as function of age, temperature and humidity. Additionally, Optical Coherence Tomography around 1300 nm was used to confirm quantitative spectral analysis approach. CONCLUSIONS: The oxidation rate of HbO(2 in bloodstains is biphasic. At first, the oxidation of HbO(2 is rapid, but slows down after a few hours. These oxidation rates are strongly temperature dependent. However, the oxidation of HbO(2 seems to be independent of humidity, whereas the transition of met-Hb into HC strongly depends on humidity. Knowledge of these decay rates is indispensable for translating laboratory results into forensic practice, and to enable bloodstain age determination on the crime scene.

  12. Thalassemia and Hemoglobin E in Southern Thai Blood Donors

    Kruachan, Kwanta; Sengking, Warachaya; Horpet, Dararat; Sungyuan, Ubol

    2014-01-01

    Thalassemia and hemoglobin E (Hb E) are common in Thailand. Individuals with thalassemia trait usually have a normal hemoglobin concentration or mild anemia. Therefore, thalassemic individuals who have minimum acceptable Hb level may be accepted as blood donors. This study was aimed at determining the frequency of α-thalassemia 1 trait, β-thalassemia trait, and Hb E-related syndromes in Southern Thai blood donors. One hundred and sixteen voluntary blood donors, Southern Thailand origin, were recruited for thalassemia and Hb E screening by red blood cell indices/dichlorophenolindophenol precipitation test. β-Thalassemia and Hb E were then identified by high performance liquid chromatography and 4 common α-thalassemia deletions were characterized by a single tube-multiplex gap-polymerase chain reaction. Overall frequency of hemoglobinopathies was 12.9%, classified as follows: homozygous α-thalassemia 2 (1.7%), heterozygous α-thalassemia 1 (1.7%), heterozygous β-thalassemia without α-thalassemia (0.9%), heterozygous Hb E without α-thalassemia (5.2%), double heterozygotes for Hb E/α-thalassemia 1 (1.7%), homozygous Hb E without α-thalassemia (0.9%), and homozygous Hb E with heterozygous α-thalassemia 2 (0.9%). The usefulness of thalassemia screening is not only for receiving highly effective red blood cells in the recipients but also for encouraging the control and prevention program of thalassemia in blood donors. PMID:25050123

  13. Infant Responsiveness, Alertness, Hemoglobin and Growth in Rural Sidama, Ethiopia

    Aubuchon-Endsley, Nicki L.; Grant, Stephanie L.; Thomas, David G.; Kennedy, Tay S.; Berhanu, Getenesh; Stoecker, Barbara J.; Hubbs-Tait, Laura; Hambidge, K. Michael

    2011-01-01

    Several recent studies have supported relations between infant behavior (alertness and responsiveness) and nutrition (e.g. Dempsey 2008, Wachs et al 2005) in addition to investigating infant behavior within the context of changes in iron status over time (e.g. Black et al. 2004, Murray-Kolb & Beard 2009). Existing research is typically limited to investigation of the effects of a single vitamin or mineral and no studies have been found that examined the influence that early alertness and responsiveness have on growth in early infancy, despite the fact that relations between behavior and nutritional status may be bidirectional (Hulthén 2003). The current study used a sample of Ethiopian infants and investigated anthropometrics, hemoglobin, the frequency of alertness, and the frequency of responsiveness at 6 and 9 months of age. Six-month weight-for-age predicted 9-month frequency of alertness, while 6-month hemoglobin predicted 9-month frequency of responsiveness. Compared to responsive infants, non-responsive infants at 6 months remained more non-responsive at 9 months, though weight-for-age for both groups converged at 9 months. Results support relations between nutrition and behavior (alertness and responsiveness) and provide evidence of a potentially useful tool (the Laboratory Temperament Assessment Battery [Lab-TAB]) that was adapted to evaluate these relations in Ethiopia. PMID:22233352

  14. Multiwavelength pulse oximetry in the measurement of hemoglobin fractions

    Manzke, Bernd; Schwider, Johannes; Lutter, Norbert O.; Engelhardt, Kai; Stork, Wilhelm

    1996-04-01

    The two wavelength design of the majority of pulse oximeters assumes only two absorbing hemoglobin fractions, oxyhemoglobin (O2Hb), and reduced hemoglobin (HHb) irrespective of the presence of methemoglobin (MetHb) and carboxyhemoglobin (COHb). If MetHb or COHb is present, it contributes to the pulse-added absorbance signal and will be interpreted as either HHb or O2Hb or some combination of the two. In this paper we describe a noninvasive multi-wavelength pulse oximeter measuring O2Hb, HHb, MetHb, and COHb at a specified accuracy of 1.0%. The system was designed with respect to the results of numerical simulations. It consists of 9 laserdiodes (LDs) and 7 light emitting diodes (LEDs), a 16-bit analog-digital converter (ADC) and has a sampling rate of 16 kHz. The laser didoes and LEDs were coupled into multi-mode fibers and led with a liquid lightguide to the finger clip and then the photodiode. It also presents the results of a clinical study, including a setup with a quartz tungsten halogen lamp (with fiber output) and a diode array spectrometer, a standard pulse oximeter and two in-vitro oximeters (radiometer OSM3 and radiometer ABL 520) as references.

  15. Moessbauer spectroscopic studies of hemoglobin and its isolated subunits

    Hoy, G.R.; Cook, D.C.; Berger, R.L.; Friedman, F.K.

    1986-01-01

    Samples of 90% enriched 57Fe hemoglobin and its isolated subunits have been prepared. Moessbauer spectroscopic measurements have been made on three such samples. Sample one contained contributions of oxyhemoglobin, deoxyhemoglobin, and carbonmonoxyhemoglobin. This sample was studied from a temperature of 90 K down to 230 mK. Measurements were also made at 4.2 K using a small applied magnetic field of 1.0 T. In general, the measured quadrupole splittings and isomer shifts for each component agreed with previous measurements on single component samples in the literature, and thus demonstrated that chemically enriched hemoglobin has not been altered. The second and third samples were isolated alpha and beta subunits, respectively. We have found measurable Moessbauer spectral differences between the HbO 2 sites in the alpha subunit sample and the beta subunit sample. The measured Moessbauer spectral areas indicate that the iron ion has the largest mean-square displacement at the deoxy Hb sites as compared to that at the oxy- and carbonmonoxy Hb sites. The mean-square displacement at the HbO 2 sites is the smallest

  16. Motifs et manifestations de l’amour de l’homme pour Dieu et l’amour du prochain selon Saint Basile le Grand

    Ernest Janczyk

    2017-04-01

    Full Text Available This article addresses the issue of the motivation of the fundamental order of love for God and the neighbour which Saint Basil the Great used in his doctrine. Based on an analysis of the texts of Saint Basil, this article demonstrates the intimate relationship that should exist between the love for God and the love for man. The ideal of this relationship is represented, according to the analysis, by Jesus Christ, the only Saviour of the world.

  17. Oxidative stress in preeclampsia and the role of free fetal hemoglobin

    Stefan Rocco Hansson

    2015-01-01

    Full Text Available Preeclampsia is a leading cause of pregnancy complications and affects 3–7 % of pregnant women. This review summarizes the current knowledge of a new potential etiology of the disease, with a special focus on hemoglobin-induced oxidative stress. Furthermore, we also suggest hemoglobin as a potential target for therapy. Gene and protein profiling studies have shown increased expression and accumulation of free fetal hemoglobin in the preeclamptic placenta. Predominantly due to oxidative damage to the placental barrier, fetal hemoglobin leaks over to the maternal circulation. Free hemoglobin and its metabolites are toxic in several ways; a ferrous hemoglobin (Fe2+ binds strongly to the vasodilator nitric oxide and reduces the availability of free nitric oxide, which results in vasoconstriction, b hemoglobin (Fe2+ with bound oxygen spontaneously generates free oxygen radicals and c the heme groups create an inflammatory response by inducing activation of neutrophils and cytokine production. The endogenous protein α1-microglobulin, with radical and heme binding properties, has shown both ex vivo and in vivo to have the ability to counteract free hemoglobin-induced placental and kidney damage. Oxidative stress in general, and more specifically fetal hemoglobin-induced oxidative stress, could play a key role in the pathology of preeclampsia seen both in the placenta and ultimately in the maternal endothelium.

  18. In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure.

    Wang, Yu; Hu, Song; Maslov, Konstantin; Zhang, Yu; Xia, Younan; Wang, Lihong V

    2011-04-01

    We developed dual-modality microscope integrating photoacoustic microscopy (PAM) and fluorescence confocal microscopy (FCM) to noninvasively image hemoglobin oxygen saturation (sO₂) and oxygen partial pressure (pO₂) in vivo in single blood vessels with high spatial resolution. While PAM measures sO₂ by imaging hemoglobin optical absorption at two wavelengths, FCM quantifies pO₂ using phosphorescence quenching. The variations of sO₂ and pO₂ values in multiple orders of vessel branches under hyperoxic (100% oxygen) and normoxic (21% oxygen) conditions correlate well with the oxygen-hemoglobin dissociation curve. In addition, the total concentration of hemoglobin is imaged by PAM at an isosbestic wavelength.

  19. Purification, characterization and sequence analyses of the extracellular giant hemoglobin from Oligobrachia mashikoi

    Nakagawa, Taro; Onoda, Seiko; Kanemori, Masaaki; Sasayama, Yuichi; Fukumori, Yoshihiro

    2005-01-01

    We purified an extracellular hemoglobin with the molecular mass of ca. 440 kDa from the whole homogenates of Oligobrachia mashikoi (phylum Pogonophora) by a one-step gel-filtration. The preparation was pure to be crystallized. The P50 values of the hemoglobin and the fresh blood prepared from O. mashikoi were about 0.82 Torr and 0.9 Torr, respectively, which were much lower than the P50 value of human hemoglobin. However, the n values of the hemoglobin and the blood were about 1.2 and 1.1, re...

  20. An analysis of postoperative hemoglobin levels in patients with a fractured neck of femur.

    Nagra, Navraj S; van Popta, Dmitri; Whiteside, Sigrid; Holt, Edward M

    2016-10-01

    The aim of this study was to analyze the changes in hemoglobin level and to determine a suitable timeline for post-operative hemoglobin monitoring in patients undergoing fixation of femoral neck fracture. Patients who underwent either dynamic hip screw (DHS) fixation (n = 74, mean age: 80 years) or hip hemiarthroplasty (n = 104, mean age: 84 years) for femoral neck fracture were included into the study. The hemoglobin level of the patients was monitored perioperatively. Analysis found a statistically and clinically significant mean drop in hemoglobin of 31.1 g/L over time from pre-operatively (D0) to day-5 post-operatively (p hemoglobin values over hemiarthroplasty patients (p = 0.046). The decrease in hemoglobin in the first 24-h post-operative period (D0 to day-1) is an underestimation of the ultimate lowest value in hemoglobin found at day-2. Relying on the day-1 hemoglobin could be detrimental to patient care. We propose a method of predicting patients likely to be transfused, and recommend a protocol for patients undergoing femoral neck fracture surgery to standardize postoperative hemoglobin monitoring. Level IV Prognostic study. Copyright © 2016 Turkish Association of Orthopaedics and Traumatology. Production and hosting by Elsevier B.V. All rights reserved.