WorldWideScience

Sample records for hematurias hereditarias benignas

  1. Loin pain hematuria syndrome.

    Science.gov (United States)

    Taba Taba Vakili, Sahar; Alam, Tausif; Sollinger, Hans

    2014-09-01

    Loin pain hematuria syndrome is a rare disease with a prevalence of ∼0.012%. The most prominent clinical features include periods of severe intermittent or persistent unilateral or bilateral loin pain accompanied by either microscopic or gross hematuria. Patients with loin pain hematuria syndrome initially present with hematuria, flank pain, or most often both hematuria and flank pain. Kidney biopsies from patients with loin pain hematuria typically reveal only minor pathologic abnormalities. Further, loin pain hematuria syndrome is not associated with loss of kidney function or urinary tract infections. Loin pain hematuria syndrome-associated hematuria and pain are postulated to be linked to vascular disease of the kidney, coagulopathy, renal vasospasm with microinfarction, hypersensitivity, complement activation on arterioles, venocalyceal fistula, abnormal ureteral peristalsis, and intratubular deposition of calcium or uric acid microcrystals. Many patients with loin pain hematuria syndrome also meet criteria for a somatoform disorder, and analgesic medications, including narcotics, commonly are used to treat loin pain hematuria syndrome-associated pain. Interventional treatments include renal denervation, kidney autotransplantation, and nephrectomy; however, these methods should be used only as a last resort when less invasive measures have been tried unsuccessfully. In this review article, we discuss and critique current clinical practices related to loin pain hematuria syndrome pathophysiology, diagnosis, treatment, and prognosis. Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  2. CT urography and hematuria

    DEFF Research Database (Denmark)

    Bretlau, Thomas; Hansen, Rasmus H; Thomsen, Henrik S

    2015-01-01

    BACKGROUND: Computed tomography (CT) urography is now used in the work-up of patients with hematuria. The dose of contrast medium and radiation varies considerably between the different CT protocols. PURPOSE: To study the disease prevalence in a consecutive group of patients with hematuria...

  3. Imaging of hematuria.

    LENUS (Irish Health Repository)

    O'Connor, Owen J

    2012-02-03

    Hematuria may have a number of causes, of which the more common are urinary tract calculi, urinary tract infection, urinary tract neoplasms (including renal cell carcinoma and urothelial tumors), trauma to the urinary tract, and renal parenchymal disease. This article discusses the current status of imaging of patients suspected of having urologic causes of hematuria. The role of all modalities, including plain radiography, intravenous urography or excretory urography, retrograde pyelography, ultrasonography, and multidetector computed tomography (MDCT) in evaluation of these patients is discussed. The article highlights the current status of MDCT urography in imaging of patients with hematuria, and discusses various-often controversial-issues, such as optimal protocol design, accuracy of the technique in imaging of the urothelium, and the significant issue of radiation dose associated with MDCT urography.

  4. Imaging of hematuria.

    LENUS (Irish Health Repository)

    O'Connor, Owen J

    2010-10-01

    OBJECTIVE: In this article, we will discuss the current status of imaging in patients with hematuria of urologic origin. Issues impacting evaluation of these patients with radiography, excretory urography, retrograde pyelography, and sonography will be discussed. CONCLUSION: Conventional radiography has no role in the detection of renal or urothelial carcinoma. Low-dose CT offers much greater sensitivities for the detection of urinary tract calculi than radiography at doses equivalent to conventional radiography. Ultrasound alone is insufficient for imaging of hematuria. Using ultrasound alone, it is often difficult to differentiate renal transitional cell carcinoma from other causes of filling defects of the renal collecting system such as blood clots, sloughed papillae, or fungus balls. The prominence of the role of excretory urography in the evaluation of patients with hematuria has diminished, and MDCT urography is now preferred to excretory urography in most cases.

  5. Las sorderas hereditarias: Algunos apuntes necesarios

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    Ibis Menéndez Alejo

    1995-12-01

    Full Text Available Las sorderas congénitas severas tienen una incidencia de 4 a 8 por 1 000 nacidos vivos. El 50 % de éstas son por causas genéticas. La genética molecular abre un camino nuevo para la interpretación, diagnóstico y prevención de las sorderas hereditarias. La localización de genes en sorderas hereditarias no sindrómicas, está muy relacionada con los avances tecnológicos que se han producido, pero depende en particular, de la identificación de familias numerosas cuyos miembros estén debidamente estudiados desde el punto de vista clínico, audiológico y genético. Para ello resulta imprescindible que el audiólogo posea conocimientos básicos de genética, el genetista conocimientos básicos de dicha especialidad y el médico de la familia esté advertido del papel crucial que desempeña la genética en estos cuadros.

  6. Enfermedades hereditarias monogénicas y multifactoriales

    OpenAIRE

    Cruz Cubas, Antonio

    2007-01-01

    En el lenguaje de la genética, es corriente distinguir según sus causas- dos grandes grupos de patologías hereditarias: las “monogénicas” y las “multifactoriales Las enfermedades monogénicas son provocadas por mutacion(es) génica(s) necesaria(s) y suficiente(s)

  7. Renal US in children with asymptomatic hematuria

    International Nuclear Information System (INIS)

    Brody, A.S.; Strife, J.L.; Bisset, G.S. III.

    1987-01-01

    The authors reviewed the renal US clinical evaluation, and laboratory data of 78 pediatric patients referred for asymptomatic hematuria. Patients with known renal disease, trauma, mass, infection, or severe pain were excluded. Thirty-two presented with gross hematuria. Nine had abnormal findings on US (28%). Increased echogenicity was the most common abnormality. Forty-five presented with microscopic hematuria. Eight had abnormal findings on US (18%). Bladder wall thickening was the most common abnormality. All patients with renal disease or significant anatomic abnormalities presented with gross hematuria and/or associated abnormalities in history, physical examination, or urinalysis. In asymptomatic patients with microscopic hematuria, significant US abnormalities are rare

  8. Cadmium exposure induces hematuria in Korean adults

    Energy Technology Data Exchange (ETDEWEB)

    Han, Seung Seok [Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744 (Korea, Republic of); Kim, Myounghee, E-mail: dkkim73@gmail.com [Department of Dental Hygiene, College of Health Science, Eulji University, Gyeonggi-do 461-713 (Korea, Republic of); Lee, Su Mi [Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744 (Korea, Republic of); Lee, Jung Pyo [Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul 156-707 (Korea, Republic of); Kim, Sejoong [Department of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do 463-707 (Korea, Republic of); Joo, Kwon Wook [Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744 (Korea, Republic of); Lim, Chun Soo [Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul 156-707 (Korea, Republic of); Kim, Yon Su; Kim, Dong Ki [Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744 (Korea, Republic of)

    2013-07-15

    Introduction: Toxic heavy metals have adverse effects on human health. However, the risk of hematuria caused by heavy metal exposure has not been evaluated. Methods: Data from 4701 Korean adults were obtained in the Korean National Health and Nutritional Examination Survey (2008–2010). Blood levels of the toxic heavy metals cadmium, lead, and mercury were measured. Hematuria was defined as a result of ≥+1 on a urine dipstick test. The odds ratios (ORs) for hematuria were measured according to the blood heavy metal levels after adjusting for multiple variables. Results: Individuals with blood cadmium levels in the 3rd and 4th quartiles had a greater OR for hematuria than those in the 1st quartile group: 3rd quartile, 1.35 (1.019–1.777; P=0.037); 4th quartile, 1.52 (1.140–2.017; P=0.004). When blood cadmium was considered as a log-transformed continuous variable, the correlation between blood cadmium and hematuria was significant: OR, 1.97 (1.224–3.160; P{sub trend}=0.005). In contrast, no significant correlations between hematuria and blood lead or mercury were found in the multivariate analyses. Discussion: The present study shows that high cadmium exposure is associated with a risk of hematuria. -- Highlights: • A high level of blood cadmium is associated with a high risk of hematuria. • This correlation is independent of several confounding factors. • Blood levels of lead and mercury are not associated with risk of hematuria. • This is the first study on the correlation between cadmium exposure and hematuria risk.

  9. Leech in urinary bladder causing hematuria.

    Science.gov (United States)

    Alam, Shadrul; Das Choudhary, Mrigen Kumar; Islam, Kabirul

    2008-02-01

    To estimate efficacy of normal saline in the management of hematuria caused by accidental entry of a leech per urethra into the urinary bladder. An intervention study was carried out in the Department of Pediatric Surgery of Sylhet MAG Osmani Medical College between January 1998 and December 2003. A total of 43 boys (mean age 8 years, SD+/-2.6) were enrolled. In all cases, a leech had entered the urinary bladder through the urethra causing hematuria. All patients were equipped with a self-retaining Foley catheter. They were managed by infusing 50ml of normal saline into the urinary bladder through the catheter that was then clamped for 3h. After removing the catheter, in all cases the whole leech was spontaneously expelled intact, dead or alive, within 2-24h during the subsequent act of micturition. Hematuria gradually diminished to a clear flow within the next 6h in 27 cases, 12h in 14 cases and 24h in two cases. All patients were followed up for 2 weeks, and none developed recurrent hematuria. Catheterization and irrigation of the urinary bladder with normal saline is a relatively simple, safe and inexpensive method of removing the leech and controlling hematuria.

  10. Evaluation of hematuria in anticoagulated patients

    International Nuclear Information System (INIS)

    Cuttino, J.T.; Clark, R.L.

    1986-01-01

    To determine the efficacy of investigating hematuria in anticoagulated patients the authors examined records of 25 consecutive patients with hematuria who were on an anticoagulation regimen with sodium warfarin (Coumadin) for various thromboembolic disorders. All had undergone intravenous urography (IVU) and 12 had undergone cystoscopy. Potential bleeding sources were discovered in 14 patients by IVU and in seven patients by cystoscopy. Disorders found were renal stones (4), transitional carcinoma (1), lymphoma (1), retroperitoneal hematoma (1), bladder tumors (2), calcified renal mass (1), hemorrhagic cystitis (2), and enlarged prostate (7). In 18 (72%) patients, the findings on IVU and/or cystoscopy were abnormal. Hematuria is a serious symptom that warrants investigation in anticoagulated as well as nonanticoagulated patients

  11. Castleman's Disease: An Interesting Cause of Hematuria.

    Science.gov (United States)

    Tolofari, Sotonye Karl; Chow, Wai-Man; Hussain, Basharat

    2015-03-01

    Castleman's disease is a rare benign lymphoproliferative disorder, characterized by benign growths of the lymph node tissue. It is associated with a number of malignancies, including Kaposi sarcoma, non-Hodgkin's and Hodgkins lymphoma, and POEMS syndrome. This report describes the case of a 38 year old gentleman, presenting with painless hematuria. Initial investigations, including flexible cystoscopy were unremarkable. However, subsequent imaging including CT Urogram and MR pelvis revealed multiple prevesical lesions. Histology obtained from excision biopsy revealed histological features consistent with Castleman's disease. In this report we discuss the nature, presentation and treatment modalities of this rare condition.

  12. Creation and validation of a visual macroscopic hematuria scale for optimal communication and an objective hematuria index.

    Science.gov (United States)

    Wong, Lih-Ming; Chum, Jia-Min; Maddy, Peter; Chan, Steven T F; Travis, Douglas; Lawrentschuk, Nathan

    2010-07-01

    Macroscopic hematuria is a common symptom and sign that is challenging to quantify and describe. The degree of hematuria communicated is variable due to health worker experience combined with lack of a reliable grading tool. We produced a reliable, standardized visual scale to describe hematuria severity. Our secondary aim was to validate a new laboratory test to quantify hemoglobin in hematuria specimens. Nurses were surveyed to ascertain current hematuria descriptions. Blood and urine were titrated at varying concentrations and digitally photographed in catheter bag tubing. Photos were processed and printed on transparency paper to create a prototype swatch or card showing light, medium, heavy and old hematuria. Using the swatch 60 samples were rated by nurses and laymen. Interobserver variability was reported using the generalized kappa coefficient of agreement. Specimens were analyzed for hemolysis by measuring optical density at oxyhemoglobin absorption peaks. Interobserver agreement between nurses and laymen was good (kappa = 0.51, p visual scale to grade and communicate hematuria with adequate interobserver agreement is feasible. The test for optical density at oxyhemoglobin absorption peaks is a new method, validated in our study, to quantify hemoglobin in a hematuria specimen. Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  13. Índices eritrocitarios en la esferocitosis hereditaria Erythrocyte indexes in hereditary spherocytosis

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    Silvia Eandi Eberle

    2007-12-01

    Full Text Available La esferocitosis hereditaria es un grupo heterogéneo de desórdenes caracterizados por la variabilidad en la clínica, en los defectos proteicos del citoesqueleto eritrocitario y en el tipo de herencia. Se estudió la sensibilidad y especificidad de la concentración de hemoglobina corpuscular media (CHCM y el índice de amplitud de distribución eritrocitaria (ADE en el screening diagnóstico de la esferocitosis hereditaria. Noventa y cuatro pacientes fueron comparados con niños sanos de igual sexo y edad. Todos los índices se obtuvieron por impedancia eléctrica (autoanalizador hematológico Coulter JT. En los pacientes con esferocitosis hereditaria, la CHCM (35.67±1.33 g/dl y el ADE (20.60±4.5%, fueron significativamente más elevados que en el grupo control (CHCM 33.48±0.68 g/dl, p 0.000; ADE 13.22±0.9%, p 0.000. Con los valores de corte utilizados en nuestro laboratorio (CHCM ≥ 34.5 g/dl; ADE ≥ 14.5% ambos índices elevados mostraron una sensibilidad de 81% y una especificidad de 98.9% en el screening de esferocitosis hereditaria. La combinación de ambos índices es un excelente predictor para el diagnóstico de esferocitosis hereditaria.Hereditary spherocytosis is a group of heterogenous disorders characterized by variability in its clinical manifestations, membrane protein defects and inheritance. We analysed the sensitivity and specificity of mean corpuscular hemoglobin concentration (MCHC and red cell distribution width (RDW in the diagnostic screening of hereditary spherocytosis. Ninetyfour patients were compared to equal number of healthy, age-matched children. All indexes were derived from measurements obtained by aperture impedance (Coulter Counter Model JT. In patients with hereditary spherocytosis, MCHC (35.67±1.33 g/dl and RDW (20.60±4.5% were significantly higher than in normal control subjects (MCHC 33.48±0.68 g/dl, p: 0.000; RDW 13.22±0.9%, p: 0.000. By using a cutoff for the MCHC of 34.5 g/dl and for the RDW

  14. HYPNOTHERAPY INTERVENTION FOR LOIN PAIN HEMATURIA: A CASE STUDY1

    Science.gov (United States)

    Elkins, Gary R.; Koep, Lauren L.; Kendrick, Cassie E.

    2012-01-01

    Loin pain hematuria is characterized by chronic loin pain, hematuria, and dysuria. There are no known effective treatments for loin pain hematuria and longer-term use of analgesics and surgical options are often ineffective or associated with negative side effects. This article reports on a 17-year-old female patient diagnosed with loin pain hematuria who presented with unilateral, uncontrolled loin pain following numerous unsuccessful attempts at controlling her symptoms with traditional medical interventions—including antibiotics, opioids, and renal denervation. The patient received 8 sessions of hypnotherapy. Baseline, end-point, and follow-up measures administered included the General Health Questionnaire, Hospital Anxiety and Depression Scale, McGill Pain Questionnaire, Pain Discomfort Scale, and visual analogue measures of pain, academic interference, and social interference. At follow-up, results indicated clinically significant decreases in pain, anxiety, and depression with nearly complete remission of presenting symptoms. PMID:22098573

  15. Frank hematuria as the presentation feature of acute leukemia

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    Suriya Owais

    2010-01-01

    Full Text Available Muco-cutaneous bleeding is a common presenting feature of acute leukemias. Mucosal bleeding usually manifests as gum bleeding and/or epistaxis but may occur in any mucosal surface of the body. Hematuria as an isolated or main presenting feature of acute leukemia is rare. We describe two cases of acute leukemia, a 19 year old male with acute lymphoblastic leukemia and a 52 year old male with acute myeloid leukemia, both presenting with gross hematuria. There was no demonstrable leukemic infiltration of the urinary tract on imaging studies. Hematuria in these patients was likely to be due to occult leukemic infiltration of the urinary system, aggravated by thrombocytopenia, as it subsided after starting chemotherapy. Our cases highlight that hematuria should be remembered as a rare presenting feature of acute leukemia.

  16. WhatsApp Use In The Evaluation of Hematuria.

    Science.gov (United States)

    Sener, Tarik Emre; Butticè, Salvatore; Sahin, Bahadir; Netsch, Christopher; Dragos, Laurian; Pappalardo, Rosa; Magno, Carlo

    2018-03-01

    The advancements in telemedicine provide the possibility to send photos of hematuria cases to professionals for further evaluation. We aimed to evaluate the inter-rater reliability of WhatsApp use in the evaluation of hematuria. Between December 2014 and April 2016, 212 patients were evaluated prospectively for hematuria by 2 groups of urologists; Group A: in direct contact with patients for evaluation; Group B: "blind" urologist who had no access to the patients' data but received pictures via WhatsApp. Two photos of voided urine in a sterile container were taken and sent using WhatsApp. The opinions of Group A and B about the grade of hematuria were evaluated. Shapiro-Wilk test and Fleiss' kappa statistics were used for statistical analyses. The median age of patients was 71 (min 22, max 96). The Group A urologists were in accordance in 96.22% of cases. Group B urologists had common opinions in 99.5% (n = 203) and there was almost perfect agreement between 2 groups (λ = 0.992). The number of common opinions among "blind" urologists is more than the number of common opinions among the consultants. When further classification is performed as serious and non-serious hematuria, the rate of misdiagnosing serious cases is approximately 6.5-7%. However, using WhatsApp, the urologists can differentiate normal urine and any form of hematuria with 100% accuracy. It is possible to evaluate hematuria remotely and also reduce unnecessary costs of services for hematuria of mild clinical significance by using telemedicine. WhatsApp can provide valuable aid to tertiary hospitals where the urologist is not always present as well as in rural areas. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Bleeding Diathesis in Unobserved Ground After the Diagnostic Ureterorenoscopy Gross Hematuria

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    Ižsmail Nalbant

    2014-06-01

    Full Text Available Summary: Hematuria is one of the common urological problem. The main causes of hematuria are malignancies, urinary tract infection and urinary tract stone disease. But sometimes use of anticoagulants, bleeding diathesis and intravesical chemotherapy can cause the hematuria. In our study, we aimed to present a patient with hematuria and has bleeding diathesis but detected any additional urological pathology.

  18. Familial microscopic hematuria caused by hypercalciuria and hyperuricosuria.

    Science.gov (United States)

    Praga, M; Alegre, R; Hernández, E; Morales, E; Domínguez-Gil, B; Carreño, A; Andrés, A

    2000-01-01

    We report 12 patients belonging to five different families in whom persistent isolated microhematuria was associated with hypercalciuria and/or hyperuricosuria. Four patients had episodes of gross hematuria, three patients had passed renal stones, and a history of nephrolithiasis was obtained in four of the families (80%). Calcium oxalate and uric acid crystals were commonly observed in the urine sediments. Urinary erythrocytes had a normal appearance on phase-microscopic examination. Reduction of calciuria and uricosuria by thiazide diuretics, allopurinol, forced fluid intake, and dietetic measures led to a persistent normalization of urine sediment with complete disappearance of hematuria. Determination of calcium and uric acid urinary excretions should be included in the study of familial hematuria.

  19. [Hereditary hemorrhagic telangiectasia presenting with hematuria and severe anemia].

    Science.gov (United States)

    Paz, A; Goren, E; Segal, M

    1995-07-01

    A patient with hereditary hemorrhagic telangiectasia was admitted with hematuria and severe anemia after mild recurrent episodes of epistaxis. Telangiectasias were found in the skin and buccal and nasal mucosa. No defect in the coagulation mechanism was found; thrombocyte count and function were normal. On cystoscopy, tortuous engorged vessels, some actively bleeding, were seen in the trigonal mucosa. Biopsy showed enlarged vessels in the lamina propria. Electrocoagulation of the bleeding vessels stopped hematuria, but 6 months later it recurred. This time Nd-YAG laser was used to stop the bleeding after electrocoagulation was ineffective.

  20. La complejidad de las distrofias hereditarias de la retina: un obstáculo y un reto

    OpenAIRE

    Martín Nieto, José

    2014-01-01

    ACTO conjunto de FARPE-FUNDALUCE con la SEBBM en el marco de su XXXVII Congreso. Conferencia: La complejidad de las distrofias hereditarias de la retina: Un obstáculo y un reto (José Martín Nieto).

  1. Cultura Primária de Explant de Hiperplasia Prostática Benigna

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    Patrícia Borba Martiny

    2014-01-01

    Full Text Available A Hiperplasia Prostática Benigna (HPB é um crescimento patológico e não maligno da próstata causada principalmente pela proliferação exacerbada das células epiteliais e, principalmente, estromais. Essa neoplasia benigna acomete a maioria dos homens de idade avançada, sendo a condição crônica mais prevalente entre a população masculina. Como mostrado em estudos, o desenvolvimento prostático é intimamente dependente da interação entre as variantes celulares estromais e epiteliais presentes nesta glândula. Entretanto, a cocultura de ambos os tipos celulares é de difícil estabelecimento, uma vez que os dois tipos celulares têm diferentes características de adesão à placa de cultivo celular.

  2. Macroscopic hematuria: A rare etiology in western countries

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    Bahjat Barakat

    2018-03-01

    Full Text Available Although schistosomiasis is one of the most prevalent parasitic diseases worldwide, the infection frequently being found in migrants and travelers, its recognition in Italy may be delayed as patients may either present symptoms or be asymptomatic, especially with regard to localization in the bladder, in a similar way to other infectious diseases. We report a case of urinary schistosomiasis in a young African male with persistent hematuria which did not respond to antibiotic treatment administered on suspicion of a urinary bacterial infection. The present case indicates that urinary schistosomiasis should be ruled out, especially in those patients presenting symptoms and coming from areas known to be endemic for helminthiasis. Finally, bladder polyps must be ruled out in cases of migrants with unexplained urinary inflammation associated either with or without hematuria.

  3. Vesical schistosomiasis with terminal hematuria in sub-Saharan patients.

    Science.gov (United States)

    Pereira, J; Calleja, E; Marne, C; Borque, A

    2014-03-01

    To know the characteristics of vesical schistosomiasis caused by schistosoma hematobium in immigrant patients. The retrospective study of 41 cases microbiologically diagnosed in our hospital over the last 16 years is presented. Data was collected on origin, age, presentation form, diagnostic tests and treatment. All were African patients whose ages ranged from 4 to 32 years and who had terminal macroscopic hematuria. Most of the patients (85%) were men. In all of the cases, diagnosis was by a urinary microbiological study and in one case, cystoscopy with a biopsy of a typical vesical lesion. Terminal hematuria is the most representative clinical sign. They were treated with praziquantel. The epidemiology and intermittent terminal hematuria in African patients should lead to the suspicion of vesical schistosomiasis as the first diagnostic option. Urinary microbiological study is a rapid, non-invasive, test with high diagnostic yield that would avoid performing invasive studies. Its simple treatment assures high level of compliance and consequent efficacy. Copyright © 2013 AEU. Published by Elsevier Espana. All rights reserved.

  4. Nephrolithiasis and hematuria--sometimes a stony road to diagnosis.

    Science.gov (United States)

    Sellin, L; Quack, I; Weiner, S M; Waldherr, R; Henning, B; Hofebauer, S; Rump, L C

    2005-08-01

    We report a case of a young man with a history of kidney stones. Occurrence of gross hematuria several months after the extracorporeal shock wave, lithotripsy (ESWL) treatment lead to hospitalization. By ultrasound and abdominal CT scan, the urologist could exclude post-renal causes of the gross hematuria and acute renal failure. After transfer to a department of nephrology hemodialysis was started, an immediate kidney biopsy was performed and prednisolone was administered on the same day. The kidney biopsy revealed an anti-glomerular basement membrane (GBM) disease. The renal function did not recover and the patient remained on hemodialysis. In the literature it has been hypothesized that ESWL-treated patients are prone to develop anti-GBM disease by liberation of glomerular basement antigen through the ESWL high energy shock waves. An additional hypothesis considering the higher susceptibility for anti-GBM disease among certain HLA-tissue types is discussed with regard to our case. Unfortunately, the prolonged track to diagnosis and delayed immunosuppressive treatment could not prevent poor clinical outcome. Although anti-GBM disease is a rather rare disease, it should be included as a differential diagnosis for hematuria--especially months after ESWL treatment. Otherwise early diagnosis may be missed and as in our patient immunosuppressive treatment will remain unsuccessful to recover renal function.

  5. ¿Es el gen de la hemocromatosis hereditaria un gen modificador de la enfermedad de Alzheimer familiar en Antioquia?

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    Marlene Jiménez del Río

    2005-03-01

    Full Text Available La hemocromatosis hereditaria (HH es un desorden autosómico recesivo del metabolismo del hierro, que se caracteriza clínicamente por la absorción excesiva de esta metal y su depósito en diferentes tejidos como el hígado, el páncreas, el carazón, las articulaciones yla glándula pituitarua.

  6. Hematuria intermitente: Esquistosomiasis vesical. A propósito de un caso Intermittent hematuria: Vesical schistosomosis. Concerning one case

    OpenAIRE

    D. Morales; J. Molina; A. Martínez Ortiz; V. Martínez Artola; X. Beristáin

    2009-01-01

    Presentamos un caso clínico de un paciente con esquistosomiasis vesical que consideramos inusual en nuestro entorno. El cuadro clínico de esta parasitosis es habitualmente el de una hematuria intermitente de semanas de evolución que no se resuelve con las medidas terapéuticas habituales. Debido al aumento de población inmigrante procedente de áreas endémicas, debemos pensar cada vez más en esta patología emergente. Con el tratamiento el proceso se resuelve satisfactoriamente, pudiéndose evita...

  7. Relaksasi Progresif terhadap Intensitas Nyeri Post Operasi BPH (Benigna Prostat Hyperplasia

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    Aprina Aprina

    2017-08-01

    Full Text Available Pain is one of the most common complaints in patients after experiencing a surgery. Surgery is a biphasic event against the human body that implies pain management. In post-surgery patients feel severe pain and 75% of patients have unpleasant experiences due to inadequate pain management.Based on the results of activity reports in Dr. Hi. Abdul Moeloek Public Hospital in Lampung Province in July-December 2016 obtained data operation BPH as many as 51 inhabitants. The objective of this research was to find out the effect of progressive relaxation to an intensity of pain for BPH (Benigna Prostate Hyperplasia post-surgery patient. This was a quasi-experiment research by using one group pretest and posttest design. 20 respondent samples were taken by using accidental sampling. Data were collected by using observation sheet and analyzed by using univariate and bivariate analyses with Wilcoxon sign test. The results showed that the mean value of pain before the progressive relaxation therapy equal to 5.20 with standard deviation 0.834. While the mean value of pain scale after it was 3.60 with standard deviation 0.681. Analysis with Wilcoxon sign test derived p-value 0.000 (ρ-value 0.000 < α 0.05, and the conclusion there was a significant effect the mean value of pain in the post-surgery patient’s BPH (Benigna Prostate Hyperplasia after progressive relaxation therapy. The researcher expects that the progressive relaxation therapy can be used by more operational methods.

  8. Endovascular treatment of a basilar artery dissecting aneurysm Fasciculações benignas responsivas à gabapentina

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    Cassiano Mateus Forcelini

    2007-12-01

    Full Text Available Fasciculations are symptoms present in a broad spectrum of conditions, ranging from normal manifestations to motor neuron diseases. They also represent the main picture of benign fasciculation syndrome. We report a case of such syndrome: a 48-years-old woman complaining about fasciculations for three decades who remained with the symptoms even after the compensation of a disclosed hyperthyroidism. The introduction of gabapentin rendered control of her fasciculations. The available data in the literature about the therapeutic approaches for fasciculations are revised, as long as the rare reports of evolution from patients with "benign" fasciculations to cases of amyotrophic lateral sclerosis, underlining the importance of following the patients with fasciculations.Fasciculações são sintomas presentes em um amplo espectro de condições, desde manifestações normais até doenças do neurônio motor. Elas representam também o principal aspecto da síndrome de fasciculações benignas. Relatamos um caso desta síndrome: uma paciente de 48 anos com queixas de fasciculações por três décadas que, mesmo após a compensação de um quadro de hipertireoidismo, permaneceu com os sintomas. A introdução de gabapentina levou a controle das fasciculações. Os dados disponíveis na literatura sobre as abordagens terapêuticas para fasciculações são revisados, assim como os raros relatos de evolução de pacientes com fasciculações "benignas" para casos de esclerose lateral amiotrófica, salientando a importância do seguimento dos pacientes com fasciculações.

  9. Neuropatía óptica hereditaria de Leber por mutación G11778A del ADN mitocondrial. Manejo de un caso

    OpenAIRE

    Barreda Gago, David; Gómez Ledesma, Isabel; Santiago Rodríguez, María de los Ángeles; Hernández Galilea, Emiliano

    2016-01-01

    La neuropatía óptica hereditaria de Leber es una enfermedad genética mitocondrial que típicamente produce ceguera bilateral en adultos jóvenes varones. Además de la mutación del ADN mitocondrial son necesarios otros factores genéticos y ambientales para el desarrollo de la enfermedad. En la actualidad no existe un tratamiento eficaz para la neuropatía óptica hereditaria de Leber, pero el consejo genético en portadores asintomáticos es importante. Presentamos el caso clínico de un paciente de ...

  10. Acquired factor VIII inhibitor syndrome: A rare cause of hematuria

    Directory of Open Access Journals (Sweden)

    Muthuvel Seral Kannan

    2015-01-01

    Full Text Available A 50-year-old woman presented with gross hematuria for 1 month. Clinical examinations, laboratory investigations, ultrasound and contrast computed tomography were normal, except anemia. Cystoscopy revealed bloody efflux from the right side. Retrograde pyelogram showed filling defect in the renal pelvis and biopsy was inconclusive. Renal angiogram was normal. She developed ecchymosis on the right thigh and arm with elevated activated partial thromboplastin time. The partial thromboplastin time correction study and Bethesda study confirmed the presence of acquired factor VIII inhibitor (acquired hemophilia. With flexible ureterorenoscopy, the mass in the renal pelvis was removed and its histopathology revealed clotted blood. The patient was subsequently managed with steroids and Factor eight inhibitor bypass activity.

  11. Hematuria following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer

    International Nuclear Information System (INIS)

    Gurka, Marie K; Chen, Leonard N; Bhagat, Aditi; Moures, Rudy; Kim, Joy S; Yung, Thomas; Lei, Siyuan; Collins, Brian T; Krishnan, Pranay; Suy, Simeng; Dritschilo, Anatoly; Lynch, John H; Collins, Sean P

    2015-01-01

    Hematuria following prostate radiotherapy is a known toxicity that may adversely affect a patient’s quality of life. Given the higher dose of radiation per fraction using stereotactic body radiation therapy (SBRT) there is concern that post-SBRT hematuria would be more common than with alternative radiation therapy approaches. Herein, we describe the incidence and severity of hematuria following stereotactic body radiation therapy (SBRT) for prostate cancer at our institution. Two hundred and eight consecutive patients with prostate cancer treated with SBRT monotherapy with at least three years of follow-up were included in this retrospective analysis. Treatment was delivered using the CyberKnife® (Accuray) to doses of 35–36.25 Gy in 5 fractions. Toxicities were scored using the CTCAE v.4. Hematuria was counted at the highest grade it occurred in the acute and late setting for each patient. Cystoscopy findings were retrospectively reviewed. Univariate and multivariate analyses were performed. Hematuria-associated bother was assessed via the Expanded Prostate Index Composite (EPIC)-26. The median age was 69 years with a median prostate volume of 39 cc. With a median follow-up of 48 months, 38 patients (18.3%) experienced at least one episode of hematuria. Median time to hematuria was 13.5 months. In the late period, there were three grade 3 events and five grade 2 events. There were no grade 4 or 5 events. The 3-year actuarial incidence of late hematuria ≥ grade 2 was 2.4%. On univariate analysis, prostate volume (p = 0.022) and history of prior procedure(s) for benign prostatic hypertrophy (BPH) (p = 0.002) were significantly associated with hematuria. On multivariate analysis, history of prior procedure(s) for BPH (p < 0.0001) and α 1A antagonist use (p = 0.008) were significantly associated with the development of hematuria. SBRT for prostate cancer was well tolerated with hematuria rates comparable to other radiation modalities. Patients factors

  12. Emphysematous cystitis: a rare cause of gross hematuria.

    Science.gov (United States)

    Chang, Chirn-Bin; Chang, Chia-Chu

    2011-05-01

    Emphysematous cystitis is a relatively rare infectious condition of the urinary bladder. The mortality rate is high if the diagnosis is delayed or if the treatment is inadequate. We present an uncommon case of emphysematous cystitis and highlight the risk factors for this disease. An 81-year-old man with a past medical history of type 2 diabetes and a central pontine infarction presented to the Emergency Department due to gross hematuria. Computed tomography (CT) and plain radiography revealed localized gas within the bladder that was compatible with the diagnosis of emphysematous cystitis. A Foley catheter was inserted. Urine culture grew Klebsiella pneumoniae; 2 g cefotaxime daily was initiated. Subsequent plain radiography and CT scan showed regression of intraluminal gas. We recommend CT for the definitive diagnosis of emphysematous cystitis. Adequate antibiotic therapy, strict blood glucose control, adequate drainage of urine, and early goal-directed therapy for suspected sepsis are suggested to prevent the complications of emphysematous cystitis. Copyright © 2011 Elsevier Inc. All rights reserved.

  13. Transarterial embolization for hematuria caused by renal arteriovenous malformations or fistulae

    International Nuclear Information System (INIS)

    Meng Xiaoxi; Liu Shiyuan; Dong Weihua; Dong Sheng; Jia Ningyang; Xiao Xiangsheng

    2008-01-01

    Objective: To evaluate the efficacy and safety of transarterial embolization for hematuria caused by renal arteriovenous malformation or fistulae. Methods: Seven patients with gross hematuria caused by renal arterial abnormalities were retrospectively reviewed, of which three had congenital renal arteriovenous malformations and the other four had non-neoplastic acquired renal arteriovenous fistulae. All patients were confirmed by renal arterial angiography and undergone embolization with various embolic materials. Results: Embolization was successfully carried out in all cases. Gross hematuria disappeared one to seven days after the procedure. No severe complications were encountered. No recurrence occurred within 12 to 36 months of follow-up. Conclusions: Transarterial embolization is safe and effective for hematuria caused by renal arteriovenous malformations or fistulae. (authors)

  14. Treatment of Persistent Gross Hematuria with Tranexamic Acid in Autosomal Dominant Polycystic Kidney Disease

    Directory of Open Access Journals (Sweden)

    Qing Yao

    2017-04-01

    Full Text Available Background/Aims: In this retrospective study we aimed to compare the effect of tranexamic acid (TXA vs etamsylate, two hemostatic agents, on hematuria duration in autosomal dominant polycystic kidney disease (ADPKD patients with persistent gross hematuria. Methods: This is a retrospective study of 40 patients with ADPKD and macroscopic hematuria. 20 patients receiving TXA and snake venom blood clotting enzyme injection were compared with 20 matched patients receiving etamsylate and snake venom blood clotting enzyme injection. The primary outcome was hematuria duration and the secondary outcomes were blood transfusion requirements and adverse events. Results: The hematuria duration was shorter in the TXA group compared with the etamsylate group (4[3-5] d vs 7[6-10] d, P<0.001. The volume of blood transfusion tended to be less in the TXA group than in the etamsylate group (300±115 ml vs 486±195 ml, P=0.12, and the number of patients needing a blood transfusion also tended to be lower [20% (4/20 vs 35% (7/20, P=0.29]. TXA and etamsylate were equally well tolerated and no serious adverse events were observed in both groups. Conclusions: Our study indicates that TXA treatment was more effective than etamsylate in stopping bleeding in ADPKD patients with persistent gross hematuria.

  15. Una patología social hereditaria: el suicidio en la Ciudad de México, 1876-1910

    OpenAIRE

    Reynoso, Alejandra

    2017-01-01

    Resumen: Este artículo estudia los cambios en las interpretaciones acerca del suicidio en la Ciudad de México entre 1876 y 1910, a partir del análisis de algunas obras, tesis y periódicos de la época, cuando la predisposición hereditaria empezó a cobrar importancia en las explicaciones respecto a las causas del suicidio, las cuales llegaron a su apogeo con la teoría de la degeneración, que convirtió a la herencia en su causa última. Este cambio en la concepción del suicidio se relacionó con f...

  16. EFECTO DE Tropaeolum tuberosum FRENTE A LA HIPERPLASIA PROSTÁTICA BENIGNA INDUCIDA EN RATAS HOLTZMAN

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    Gioliana Aire-Artezano

    2013-01-01

    Full Text Available Objetivo: Evaluar el efecto de Tropaeolum tuberosum(mashua frente a la Hiperplasia Prostática Benigna (HPB y compararlo con finasterida. Métodos: Estudio experimental completo. Se emplearon 30 ratas Holtzman macho de 12 semanas de edad, aleatorizadas y divididas en seis gru- pos: grupo blanco; grupo testosterona; grupo finasterida (0.33mg/kg/rata; y tres grupos dosis, dosis 1 (300mg/kg/rata, dosis 2 (500mg/kg/rata y dosis 3 (800mg/kg/rata tratados con Tropaeolum tuberosum. Se realizó una medición basal del volumen prostático mediante una ecografía transabdominal. La inducción de HPB se realizó con enantato de testosterona (0,083mg/Kg/rata en los grupos dosis, finasterida y testosterona, el día uno y siete. Paralelamente, se administró liofilizado de Tropaeolum tuberosum y finasterida durante 21 días. Para el diagnóstico, se realiza- ron estudios por imágenes, anatomopatológicos e histopatológicos. Resultados: El estudio por imágenes, en relación al incremento del volumen prostático,no arrojó diferencia significativa entre dosis 2 y finasterida; mientras que en relación con la ecogenicidad, dosis 3 presentó similitud cualitativa al finasterida. En el estudio anatomopatológico, no hubo diferencia significativa entre el grupo dosis 3 y el grupo finasterida. Histo- patológicamente, dosis 3 se asemejó cuantitativamente al finasterida. Conclusiones: Se evidenció disminución de la HPB histológicamente y en el estudio por imágenes; sin embargo, ninguna de las dosis mostró efecto superior al finasterida.

  17. Biologia da nidificação de Megachile (Moureapis benigna Mitchell

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    Frederico Teixeira

    2011-11-01

    Abstract. This paper describes the biology, ecology and nest architecture of Megachile (Moureapis benigna Mitchell in trap nests (NA. The NA were installed in five forest fragments of 2.1 to 920ha, and two disturbed areas (pasture and plantation. We used bamboo canes (NB and black cardboard tubes placed on wooden boards (NC to attract nesting females. Bees occupied 17 NA (12 NB - 9 to 21mm in diameter - and 5 NC - 8 to 10mm in four forest fragments forming 26 nests (one to six nests per NB. No nest was founded in disturbed areas. There was no difference between NB and NC related to the size of formed nests (t= 0.31, p= 0.763, df= 25. The number of cells ranged from 1 to 13 per nest, being larger in NB than in NC (t= 2.26, p= 0.033, df= 25. The construction activity occurred during the rainy season (October to March, with no correlation to climate parameters. Emergence (1 to 12 per nest was correlated with humidity (t= 3.013, p= 0.006. Time to adult emergence varied from 1 to 141 days. The sex ratio was 1.8:1 male/female, differing from 1:1 (Χ2= 9.39, p<0.002. The parasites were Coelioxys otomita Cresson and two other species of Coelioxys. The species demonstrates plasticity in nesting substrate, and preference for cavities with diameters larger than 9mm. There is a possible dependence of the species to forest environments, since the higher occurrence of nesting was in forest areas in advanced stages of regeneration.

  18. Macroscopic Hematuria After Conventional or Hypofractionated Radiation Therapy: Results From a Prospective Phase 3 Study

    Energy Technology Data Exchange (ETDEWEB)

    Sanguineti, Giuseppe, E-mail: sanguineti@ifo.it [Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome (Italy); Arcidiacono, Fabio [Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome (Italy); Landoni, Valeria [Department of Physics, Regina Elena National Cancer Institute, Rome (Italy); Saracino, Bianca Maria; Farneti, Alessia; Arcangeli, Stefano; Petrongari, Maria Grazia; Gomellini, Sara [Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome (Italy); Strigari, Lidia [Department of Physics, Regina Elena National Cancer Institute, Rome (Italy); Arcangeli, Giorgio [Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome (Italy)

    2016-10-01

    Purpose: To assess the macroscopic hematuria rates within a single-institution randomized phase 3 trial comparing dose-escalated, conventionally fractionated radiation therapy (CFRT) and moderately hypofractionated radiation therapy (MHRT) for localized prostate cancer. Methods and Materials: Patients with intermediate- to high-risk localized prostate cancer were treated with conformal RT and short-course androgen deprivation. Both the prostate and the entire seminal vesicles were treated to 80 Gy in 40 fractions over 8 weeks (CFRT) or 62 Gy in 20 fractions over 5 weeks (MHRT). The endpoint of the present study was the development of any episode or grade of macroscopic hematuria. The median follow-up period was 93 months (range 6-143). Results: Macroscopic hematuria was reported by 25 of 168 patients (14.9%). The actuarial estimate of hematuria at 8 years was 17.0% (95% confidence interval [CI] 10.7%-23.3%). The number of patients with hematuria was 6 and 19 in the CFRT and MHRT arms, respectively, for an actuarial 8-year estimate of 9.7% and 24.3%, respectively (hazard ratio 3.468, 95% CI 1.385-8.684; P=.008). Overall, 8 of 25 patients were found to have biopsy-proven urothelial carcinoma (3 in the CFRT arm and 5 in the MHRT arm; P=.27). Thus, the 8-year actuarial incidence of macroscopic hematuria (after censoring urothelial cancer–related episodes) was 4.1% and 18.2% after CFRT and MHRT, respectively (hazard ratio 4.961, 95% CI 1.426-17.263; P=.012). The results were confirmed by multivariate analysis after accounting for several patient-, treatment-, and tumor-related covariates. Conclusions: MHRT was associated with a statistically significant increased risk of macroscopic hematuria compared with CFRT.

  19. Macroscopic Hematuria After Conventional or Hypofractionated Radiation Therapy: Results From a Prospective Phase 3 Study

    International Nuclear Information System (INIS)

    Sanguineti, Giuseppe; Arcidiacono, Fabio; Landoni, Valeria; Saracino, Bianca Maria; Farneti, Alessia; Arcangeli, Stefano; Petrongari, Maria Grazia; Gomellini, Sara; Strigari, Lidia; Arcangeli, Giorgio

    2016-01-01

    Purpose: To assess the macroscopic hematuria rates within a single-institution randomized phase 3 trial comparing dose-escalated, conventionally fractionated radiation therapy (CFRT) and moderately hypofractionated radiation therapy (MHRT) for localized prostate cancer. Methods and Materials: Patients with intermediate- to high-risk localized prostate cancer were treated with conformal RT and short-course androgen deprivation. Both the prostate and the entire seminal vesicles were treated to 80 Gy in 40 fractions over 8 weeks (CFRT) or 62 Gy in 20 fractions over 5 weeks (MHRT). The endpoint of the present study was the development of any episode or grade of macroscopic hematuria. The median follow-up period was 93 months (range 6-143). Results: Macroscopic hematuria was reported by 25 of 168 patients (14.9%). The actuarial estimate of hematuria at 8 years was 17.0% (95% confidence interval [CI] 10.7%-23.3%). The number of patients with hematuria was 6 and 19 in the CFRT and MHRT arms, respectively, for an actuarial 8-year estimate of 9.7% and 24.3%, respectively (hazard ratio 3.468, 95% CI 1.385-8.684; P=.008). Overall, 8 of 25 patients were found to have biopsy-proven urothelial carcinoma (3 in the CFRT arm and 5 in the MHRT arm; P=.27). Thus, the 8-year actuarial incidence of macroscopic hematuria (after censoring urothelial cancer–related episodes) was 4.1% and 18.2% after CFRT and MHRT, respectively (hazard ratio 4.961, 95% CI 1.426-17.263; P=.012). The results were confirmed by multivariate analysis after accounting for several patient-, treatment-, and tumor-related covariates. Conclusions: MHRT was associated with a statistically significant increased risk of macroscopic hematuria compared with CFRT.

  20. Reabilitação vestibular da vertigem postural paroxística benigna de canal posterior em idosos

    OpenAIRE

    Ana Paula do Rego André

    2003-01-01

    A Reabilitação Vestibular (RV) é um programa de tratamento realizado por exercícios, associado a um conjunto de medidas relacionadas à mudança de hábitos e esclarecimentos sobre os sintomas associados à alteração do equilíbrio. É um método de terapia fisiológico, inócuo e coerente, que pretende trabalhar o paciente vertiginoso aliviando os sintomas e aumentando seu limiar de sensibilidade para a vertigem. A Vertigem Postural Paroxística Benigna (VPPB) é a mais comum das vestibulopatias perifé...

  1. Neuropatía óptica hereditaria de Leber por mutación G11778A del ADN mitocondrial. Manejo de un caso

    Directory of Open Access Journals (Sweden)

    David Barreda Gago

    2016-11-01

    Full Text Available La neuropatía óptica hereditaria de Leber es una enfermedad genética mitocondrial que típicamente produce ceguera bilateral en adultos jóvenes varones. Además de la mutación del ADN mitocondrial son necesarios otros factores genéticos y ambientales para el desarrollo de la enfermedad. En la actualidad no existe un tratamiento eficaz para la neuropatía óptica hereditaria de Leber, pero el consejo genético en portadores asintomáticos es importante. Presentamos el caso clínico de un paciente de 23 años de edad que refiere pérdida de agudeza visual central aguda unilateral que se convierte en bilateral en semanas. La exploración del fondo de ojo (tortuosidad vascular peripapilar, telangiectasias e hiperemia papilar, la angiografía con fluoresceína (con ausencia de exudación y el engrosamiento de la capa de fibras nerviosas nos hacen sospechar la enfermedad. El test genético molecular confirma la neuropatía óptica hereditaria de Leber al encontrar la mutación G11778A en homoplasmia. A pesar del tratamiento con idebenona y suplementos vitamínicos la enfermedad evoluciona a atrofia papilar bilateral. El futuro parece estar en la terapia génica, actualmente en investigación.

  2. 34. Estenoses traqueais benignas: experiência de um serviço de pneumologia

    Directory of Open Access Journals (Sweden)

    Marina Bonnet

    2003-11-01

    Full Text Available Estudo retrospectivo de oito anos e meio (1995/ Junho 2003 da experiência do Serviço de Pneumologia do Hospital Garcia de Orta em casos de estenose traqueal benigna.Foram estudados 36 doentes, entre os quais três lactentes, na sua maioria do sexo feminino (58%, cuja a média etária é de 51,8 anos, excluindo os lactentes cujas as idades variam entre um e seis meses. Os tipos de estenoses são variados: simples, diafragmas, complexas e casos de traqueobroncomalacia.A etiologia é múltipla salientando-se no entanto a maioria de casos como resultante de complicação da entubação oro/nasotraqueal; são também descritos casos de estenoses idiopáticas, congénitas, pós traqueotomia e pós cirurgia.As atitudes terapêuticas face às estenoses e às suas complicações variaram entre a simples vigilância e a utilização de técnicas mais complexas, nomeadamente, electrocoagulação de alta frequência, laserterapia, crioterapia, dilatação, colocação de próteses e cirurgia. : Retrospective study from eight and half years of experience of the Pulmonology Service of the Hospital Garcia de Orta, in cases of benign tracheal stenosis.Thirty six patients were studied, three of them were infants, the majority were female (58%, being the mean age of 51,8 years, excluded the infants whose ages were between one and six months. The types of stenosis were various: simple, diaphragms, complexes and caused by tracheobronchomalatia.The causes were multiple but we enhance the fact that the majority were a complication of oro/nasotracheal entubation; also are described cases of idiopathic, congenital and post tracheotomy and surgery.The stenosis and complications therapeutics ranged from surveillance and the use of various bronchology techniques and surgery. Palavras-chave: estenose, traqueia, broncologia, Key-words: stenosis, trachea, bronchology

  3. Morbilidad y mortalidad por afecciones benignas del sistema biliar: Nuestra experiencia

    Directory of Open Access Journals (Sweden)

    Jorge Reyes Cardero

    1997-04-01

    Full Text Available Se realizó un estudio descriptivo y prospectivo sobre morbilidad y mortalidad por enfermedades benignas del sistema biliar en 4 266 pacientes operados en el Hospital Provincial Clinicoquirúrgico Docente "Saturnino Lora" de Santiago de Cuba, en el que se precisó la incidencia de diferentes variables. Las enfermedades más frecuentes fueron las colecistitis y colecistosis, en pacientes del sexo femenino, y un número importante de operados superaba los 60 años. Las complicaciones más comúnmente halladas en el período preoperatorio fueron: la litiasis coledociana y la pancreatitis aguda; en el peroperatorio: sobre la vesícula, la vía biliar y el hígado y en el posoperatorio inmediato las inespecíficas, que prevalecieron sobre las específicas. La mortalidad se consideró dentro de límites aceptables, y como causa fundamental de muerte en los ancianos se destaca el síndrome de disfunción múltiple de órganosA descriptive and prospective study on morbidity and mortality of bening diseases of the biliary tract was performed on 4 266 patients operated on at "Saturnino Lora" Provincial Teaching hospital, Santiago de Cuba with the aim of assessing the incidence of different variables. The most frequent diseases were found to be cholecystitis and cholecystosis in female patients, and a great number of surgically treated patients were over 60 years of age. The most frequently complications found within the preoperative period were: cholelithiasis and acute pancreatitis; during the perioperative period the most common were the complications of the gall bladder, the bile duct, and the liver, and during the immediate portoperative period the most frequent complications were found to be nonspecific which prevailed over the specific ones. Mortality rate was considered to be within acceptable limits, and the syndrome of multiple organ failure was found to be the principal cause of death among aged patients

  4. Neuropatía óptica hereditaria de Leber Leber´s hereditary optic neuropathy

    Directory of Open Access Journals (Sweden)

    Yannara Elina Columbié Garbey

    2012-06-01

    Full Text Available La neuropatía óptica hereditaria de Leber es una enfermedad de herencia materna que se caracteriza por la pérdida subaguda, indolora y bilateral, aunque por lo general no siempre al unísono de la visión central. Predomina en hombres jóvenes y es causada por mutaciones puntuales del ADN mitocondrial. Esta es una de las neuropatías ópticas hereditarias más frecuentes y altamente invalidante, cuyo diagnóstico de certeza lo constituyen los estudios moleculares. El propósito de esta revisión es alertar en cuanto a su diagnóstico y posible incremento en condiciones ambientales favorecedoras. Se realizó una búsqueda automatizada de artículos científicos relacionados con el tema, en PUBMED e Hinari, que resultó en 37 publicaciones realizadas durante los años 1988-2010. Se estudiaron y discutieron aspectos de la enfermedad tales como antecedentes históricos, factores de riesgo, epidemiología, genética, características clínicas, diagnóstico y tratamiento; además de profundizar en su estado actual en nuestro contexto. En Cuba actualmente se conoce de la existencia de varias familias que padecen la neuropatía óptica hereditaria de Leber. El alza de la incidencia probablemente se debió a las condiciones medioambientales que favorecen o son factores de riesgo de esta entidad, como ocurrió durante la pasada epidemia de neuropatía óptica en Cuba. Cada día se producen más avances en el campo de la genética, que permiten identificar un número mayor de mutaciones asociadas a esta entidad. Esto unido al conocimiento de las características clínicas de la enfermedad ha permitido identificar las familias afectadas y actuar sobre los factores de riesgo.Leber´s hereditary optic neuropathy is a maternally inherited disease characterized by subacute, painless and bilateral loss of the central vision, although not always at the same time. It predominates in young men and is caused by mitochondrial DNA spot mutations. This is one of

  5. Hematuria screening test for urinary bladder mucosal infiltration in cervical cancer.

    Science.gov (United States)

    Chuttiangtum, Ayuth; Udomthavornsuk, Banchong; Chumworathayi, Bandit

    2012-01-01

    To determine the diagnostic performance of hematuria as a screening test for urinary bladder infiltration in cervical cancer patients with a prospective study design. Newly diagnosed cervical cancer patients at Srinagarind hospital from 14 June 2011 to 30 April 2012 were enrolled in this study. We collected midstream urine samples for urinalysis from every patient before routine cystoscopic exam for clinical staging. The presence of 3 or more red blood cells (RBCs) per high power field was defined as positive for hematuria. A two-by-two table was used to determine the diagnostic performance of hematuria to detect urinary bladder mucosal infiltration using cystoscopy and biopsy as the gold standard. A total of 130 were patients included, 54 of which (41.5%) had hematuria. Of these, four patients (3.08%) had pathological report from cystoscopic biopsy confirmed metastatic squamous cell carcinoma. The sensitivity, specificity, PPV, NPV, and accuracy of hematuria as a screening test to detect urinary bladder mucosal infiltration of cervical cancer were 100%, 60.3%, 7.4%, 100%, and 61.5%, respectively. There was no single case of urinary bladder mucosal infiltration in patients initially staged less than stage III. Hematuria can be used as a screening test to detect urinary bladder mucosal infiltration of cervical cancer. This can reduce the number of cervical cancer patients who really need to undergo cystoscopy as a staging procedure to less than half and to less than 20% if stage III or more were included without missing a single case of urinary bladder mucosal infiltration.

  6. Garantías obligacionales y partición hereditaria. A propósito de la oposición de los acreedores a la partición hereditaria en Cuba

    Directory of Open Access Journals (Sweden)

    Raúl José Vega Cardona

    2015-07-01

    Full Text Available Con la puesta en vigor del Decreto – Ley 289/2011 de los Créditos a las personas naturales y otros servicios bancarios, se impone un redimensionamiento del Derecho de Obligaciones y de Contratos, al complementarse el régimen jurídico cubano sobre la adquisición de obligaciones jurídicas y con ello las nuevas regulaciones sobre el sistema de garantías obligacionales para la protección del derecho de crédito contraído. Ello deriva en indudables consecuencias no solo para esta rama del Derecho Civil, sino para todo el Derecho Privado, pero singularmente para el Derecho de Sucesiones, en tanto el fallecimiento del deudor supone una relectura del régimen legal aplicable para estos casos en miras a establecer mecanismos eficaces de protección a los acreedores del de cuius, dentro de los que se engloba la oposición a la partición hereditaria y con ello la utilidad que para los acreedores del causante puede conllevar la utilización de garantías personales y reales para su efectiva satisfacción de su derecho de crédito.

  7. Urinary bladder metastasis from lung adenocarcinoma: A rare cause of hematuria

    Directory of Open Access Journals (Sweden)

    Kan Wai Man Raymond

    2014-01-01

    Full Text Available We presented an unusual case of hematuria caused by a solitary bladder metastasis from lung adenocarcinoma. A confident diagnosis of secondary adenocarcinoma of the bladder was made by clinical suspicion based on patient′s past history, careful examination of tumor morphology, and a directed panel (cytokeratin [CK] 7/CK20/thyroid transcription factor 1 of immunohistochemistry. We sought, through sharing our experience in the investigative and diagnostic process, to contribute to the better understanding of this unusual cause of hematuria.

  8. Nutcracker Syndrome and Sickle Cell Trait: A Perfect Storm for Hematuria.

    Science.gov (United States)

    Ahmad, Amier; McElwee, Samuel K; Kraemer, Ryan R

    2017-05-01

    We describe the case of a 27-year-old woman with a history of sickle cell trait (SCT) who presented with several months of hematuria and was found to have nutcracker syndrome (NCS). While SCT is a common cause of hematuria resulting from renal papillary necrosis, our patient had concomitant abdominal pain and anemia, prompting further evaluation and the subsequent diagnosis of NCS. Interestingly, the anoxia in the left renal vein from NCS predisposes patients with SCT to sickling. Our case highlights key clinical features of both NCS and SCT and the relationship between the two disease processes.

  9. CT urography in the diagnosis of renal masses in patients with hematuria

    International Nuclear Information System (INIS)

    Warshauer, D.M.; Street, L.; McCarthy, S.M.; Glickman, M.G.; Ritcher, J.; Rosenfield, A.T.

    1987-01-01

    The optimal method for the diagnosis of renal masses in patients with hematuria has been in question since the introduction of axial imaging techniques. A prospective study comparing excretory urography and nephrotomography (EU) with limited renal CT was undertaken. Results showed EU able to detect approximately 75% of CT-confirmed masses greater than 2 cm, but less than 10% of CT masses smaller than 2 cm. These results suggest that a combination study of CT/EU utilizing a single contrast injection with EU for imaging the collecting system and CT for renal parenchymal evaluation would be the best screening study in patients with hematuria

  10. The role of imaging in the investigation of painless hematuria in adults.

    LENUS (Irish Health Repository)

    O'Regan, Kevin N

    2009-08-01

    The radiologic investigation of asymptomatic hematuria has changed significantly due to the introduction of new imaging modalities and innovative techniques, such as computed tomography urogaphy, which allows a comprehensive evaluation of the entire urinary tract in a single study. There is still a role for "older" imaging modalities, such as intravenous urography and ultrasound, and their use is still advocated in younger patients with a lower risk of malignancy to minimize radiation dose. Combined modality imaging can also be useful for characterization of lesions. Guidelines have recently been published for the radiologic investigation of hematuria; these are discussed in this article.

  11. Btryoid Wilm's tumor in a child presenting with gross hematuria: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chae Jung; Im, Young Jae; Shin, Hyun Joo; Kim, Myung Joon; Lee, Mi Jung [Severance Children' s Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2016-09-15

    We report a unique case of botryoid Wilms' tumor with its characteristic imaging findings in a 5-month-old boy presenting with gross hematuria. In our case, ultrasonography revealed lobulated hyperechoic lesions filling the pelvicalyceal system without parenchymal invasion, mimicking a blood clot. However, magnetic resonance imaging (MRI) demonstrated the exact extent of the lesion with diffusion restriction and delayed enhancement suggestive of a tumor. Despite their rarity, botryoid Wilms' tumors should be included in the differential diagnosis of lobulated renal pelvic lesions presenting as gross hematuria in children, and MRI can suggest the diagnosis.

  12. LA QUIMIOPREVENCIÓN PARA PACIENTES CON MUTACIONES HEREDITARIAS DE PREDISPOSICIÓN AL CÁNCER

    Directory of Open Access Journals (Sweden)

    Dra. Christina Adaniel

    2017-07-01

    Full Text Available Mientras buscamos maneras de prevenir el cáncer, la quimioprevención ha evolucionado como una herramienta para la reducción de riesgo. El uso de drogas u otras substancias que previenen o atrasan el inicio de cáncer en individuos sanos ha sido objeto de intensa investigación durante las últimas dos décadas. Aquellos individuos quienes en teoría deben beneficiarse más incluyen los con mutaciones genéticas germinales que confieren una predisposición al cáncer. Desafortunadamente, este grupo de individuos ha sido sub representado en los estudios clínicos y, por lo tanto, la evidencia para la quimioprevención en este grupo es limitada. Se presenta una revisión de la literatura sobre la quimioprevención primaria para el cáncer de colon, mama, ovario, y próstata en los portadores de mutaciones genéticas hereditarias.

  13. Computed tomography-urography for upper urinary tract imaging: is it required for all patients who present with hematuria?

    NARCIS (Netherlands)

    Cauberg, Evelyne C. C.; Nio, C. Y.; de la Rosette, Jean M. C. H.; Laguna, M. Pilar; de Reijke, Theo M.

    2011-01-01

    To define in which patients who present with microscopic or macroscopic hematuria CT urography (CTU) is indicated as an imaging mode for the upper urinary tract (UUT). We conducted a prospective study on consecutive patients who attended a modern protocol-driven hematuria clinic from January 2006 to

  14. Pre-diagnosis quality of life (QoL) in patients with hematuria : Comparison of bladder cancer with other causes

    NARCIS (Netherlands)

    Goossens-Laan, C.A.; Kil, P.J.M.; Bosch, J.L.; de Vries, J.

    2013-01-01

    Purpose To examine quality of life (QoL), health status, sexual function, and anxiety in patients with primary hematuria who later appear to have bladder cancer (BC) and patients with other diagnoses. Methods From July 2007 to July 2010, 598 patients with primary hematuria were enrolled in this

  15. Idiopathic renal hematuria in a dog; the usefulness of a method of partial occlusion of the renal artery.

    Science.gov (United States)

    Mishina, M; Watanabe, T; Yugeta, N; Maeda, H; Fujii, K; Wakao, Y; Takahashi, M; Yamamura, H

    1997-04-01

    Exploratory laparotomy was performed on a dog suspected of having idiopathic renal hematuria. Two catheters were inserted into the bilateral ureters, and hematuria from the left kidney was confirmed. The blood flow was occluded in the ventral and dorsal rami of the left renal artery in order to localize the site of hemorrhage. As hematuria disappeared when the dorsal ramus was occluded, the site of renal hematuria was localized to the area dominated by the dorsal ramus of the renal artery. As a result of ligating the dorsal ramus of the left renal artery in this dog, renal hematuria subsided, and the dog has shown a favorable course, to date, one year after surgery.

  16. Bladder Metastasis of non-Small Cell Lung Cancer : an Unusual Cause of Hematuria

    NARCIS (Netherlands)

    Karatas, O. Faruk; Bayrak, Reyhan; Yildirim, M. Erol; Bayrak, Omer; Cimentepe, Ersin; Unal, Dogan

    2009-01-01

    Approximately 2% of bladder malignancies are metastatic. The lung cancer makes metastasis sporadically to the bladder. A-69-year-old female patient presented with a history of pain in kidneys, vomiting and hematuria. Cystoscopic examination of the patient revealed small bladder capacity and solitary

  17. Gross hematuria as the presentation of an inguinoscrotal hernia: a case report

    Directory of Open Access Journals (Sweden)

    Ansari Kayvan

    2011-12-01

    Full Text Available Abstract Introduction Several complications have been reported with inguinal hernias. Although hematuria and flank pain, either as the presentation or as a complication of inguinal hernia, are infrequent, this condition may lead to the development of obstructive uropathy, which can have diverse manifestations. Case presentation A 71-year-old Iranian man with Persian ethnicity presented with new onset episodes of gross hematuria and left-sided flank pain. A physical examination revealed a large and non-tender inguinal hernia on his left side. An initial workup included an abdominal ultrasound, an intravenous pyelogram and cystoscopy, which showed left hydronephrosis and a bulging on the left-side of his bladder wall. On further evaluation, computed tomography confirmed that his sigmoid colon was the source of the pressure effect on his bladder, resulting in hydroureteronephrosis and hematuria. No tumoral lesion was evident. Herniorrhaphy led to the resolution of his signs and symptoms. Conclusion Our case illustrates a rare presentation of inguinal hernia responsible for gross hematuria and unilateral hydronephrosis. Urologic signs and symptoms can be caused by the content of inguinal hernias. They can also present as complications of inguinal hernias.

  18. The diagnostic efficiency of ultrasound guided imaging algorithm in evaluation of patients with hematuria

    Energy Technology Data Exchange (ETDEWEB)

    Unsal, Alparslan, E-mail: alparslanunsal@yahoo.com [Adnan Menderes University, Faculty of Medicine, Department of Radiology, 09100 Aydin (Turkey); Caliskan, Eda Kazak [Adnan Menderes University, Faculty of Medicine, Department of Radiology, 09100 Aydin (Turkey); Erol, Haluk [Adnan Menderes University, Faculty of Medicine, Department of Urology, 09100 Aydin (Turkey); Karaman, Can Zafer [Adnan Menderes University, Faculty of Medicine, Department of Radiology, 09100 Aydin (Turkey)

    2011-07-15

    Purpose: To assess the efficiency of the following imaging algorithm, including intravenous urography (IVU) or computed tomography urography (CTU) based on ultrasonographic (US) selection, in the radiological management of hematuria. Materials and methods: One hundred and forty-one patients with hematuria were prospectively evaluated. Group 1 included 106 cases with normal or nearly normal US result and then they were examined with IVU. Group 2 was composed of the remaining 35 cases which had any urinary tract abnormality, and they were directed to CTU. Radiological results were compared with clinical diagnosis. Results: Ultrasonography and IVU results of 97 cases were congruent in group 1. Eight simple cysts were detected with US and 1 non-obstructing ureter stone was detected with IVU in remaining 9 patients. The only discordant case in clinical comparison was found to have urinary bladder cancer on conventional cystoscopy. Ultrasonography and CTU results were congruent in 30 cases. Additional lesions were detected with CTU (3 ureter stones, 1 ureter TCC, 1 advanced RCC) in remaining 5 patients. Ultrasonography + CTU combination results were all concordant with clinical diagnosis. Except 1 case, radio-clinical agreement was achieved. Conclusion: Cross-sectional imaging modalities are preferred in evaluation of hematuria. CTU is the method of choice; however the limitations preclude using CTU as first line or screening test. Ultrasonography is now being accepted as a first line imaging modality with the increased sensitivity in mass detection compared to IVU. The US guided imaging algorithm can be used effectively in radiological approach to hematuria.

  19. Tratamiento farmacológico en la hiperplasia prostática benigna Pharmacological treatment of the benign prostatic hyperplasia

    Directory of Open Access Journals (Sweden)

    Yohani Pérez Guerra

    2011-03-01

    Full Text Available La hiperplasia prostática benigna, enfermedad común en hombres a partir de los 50 años de edad, consiste en el crecimiento benigno e incontrolado de la glándula prostática y produce diversos síntomas del tracto bajo urinario. Su agente causal multifactorial involucra fundamentalmente el incremento de la conversión de testosterona en dihidrotestosterona por acción de la 5 a-reductasa prostática, lo cual desencadena eventos que propician el incremento en el tamaño de la próstata (componente estático y el aumento del tono del músculo liso de vejiga y próstata (componente dinámico regulado por los adrenoreceptores (ADR-a1. El tratamiento farmacológico de la hiperplasia prostática benigna incluye los inhibidores de la 5a-reductasa, antagonistas de ADR-a1, su terapia combinada y la fitoterapia. El objetivo del presente trabajo fue presentar los aspectos más relevantes de la farmacología de los fármacos utilizados en el tratamiento de la hiperplasia prostática benigna y brindar elementos de su eficacia, seguridad y tolerabilidad. Para ello, se realizó una reseña de los diferentes fármacos utilizados en el tratamiento de esta afección, los que fueron clasificados de acuerdo con su mecanismo de acción. Se incluyeron productos de origen natural como los extractos lipídicos del Serenoa repens y Pygeum africanum, así como el D-004, extracto lipídico de los frutos de la Roystonea regia, que ejerce efectos beneficiosos sobre los principales factores causales de la hiperplasia prostática benigna, ya que es un inhibidor de la 5 a-reductasa prostática, un antagonista de los ADR-a1, un inhibidor de la 5-lipooxigenasa y tiene acción antioxidante, lo que evidencia un mecanismo multifactorial. Los resultados hasta el presente indican que el D-004 es seguro y bien tolerado.Benign prostatic hyperplasia is a common disease in over 50 years-old men consisting in uncontrolled and benign growth of prostatic gland that leads to lower urinary

  20. Esferocitosis hereditaria: avance en la metodología diagnóstica, estudios demográficos e investigación de mecanismos involucrados

    OpenAIRE

    Crisp, Renée Leonor

    2014-01-01

    La Esferocitosis Hereditaria (ESH) es una anemia hemolítica de observación frecuente, caracterizada por alteraciones cuali y/o cuantitativas –genéticamente determinadas– de las proteínas de la membrana eritrocitaria. Consecuentemente, se debilita la unión entre la membrana eritrocitaria y el citoesqueleto subyacente, produciéndose la pérdida progresiva de la membrana con formación de hematíes de forma esférica, osmóticamente frágiles, que son selectivamente atrapados y destruidos en el bazo. ...

  1. A novel mutation of the CLCN1 gene associated with myotonia hereditaria in an Australian cattle dog.

    Science.gov (United States)

    Finnigan, Daniel F; Hanna, W J Brad; Poma, Roberto; Bendall, Andrew J

    2007-01-01

    Heritable myotonia is a genetic muscle disorder characterized by slow relaxation of skeletal muscles. The main clinical signs are skeletal muscle stiffness, especially after vigorous contraction, and muscle hypertrophy. Muscle stiffness may be enhanced by inactivity, and often is relieved by exercise. Myotonia can be inherited in an autosomal dominant or recessive manner (Thomsen- or Becker-type myotonia, respectively). In mice, goats, Miniature Schnauzer dogs, and most affected humans, the disorder is caused by mutations in CLCN1, which encodes the skeletal muscle voltage-gated chloride channel, Cl1C-1. We hypothesized that an Australian Cattle Dog with generalized muscle stiffness and hypertrophy examined at the Ontario Veterinary College would have a mutation in the CLCN1 gene. A pure-bred Australian Cattle Dog from Ontario, Canada, was used. Based on clinical signs and electromyographic test results, a diagnosis of myotonia hereditaria was made, and a muscle biopsy was collected for genetic analysis. Sequence data obtained from the affected dog confirmed that it was homozygous for a single base insertion in the CLCN1 coding sequence. This mutation would result in a truncated ClC-1 protein being expressed, which, based on molecular evidence from other studies, would result in functionally compromised chloride conduction in the skeletal muscles of the animal. To the authors' knowledge, this report describes the Ist case of myotonia in an Australian Cattle Dog and represents the 1st non-Schnauzer canine myotonia to be genetically characterized. In addition, we developed a polymerase chain reaction-based genetic screen to detect heterozygotes with this mutation in the at-large Australian Cattle Dog population.

  2. Genome-wide linkage, exome sequencing and functional analyses identify ABCB6 as the pathogenic gene of dyschromatosis universalis hereditaria.

    Directory of Open Access Journals (Sweden)

    Hong Liu

    Full Text Available As a genetic disorder of abnormal pigmentation, the molecular basis of dyschromatosis universalis hereditaria (DUH had remained unclear until recently when ABCB6 was reported as a causative gene of DUH.We performed genome-wide linkage scan using Illumina Human 660W-Quad BeadChip and exome sequencing analyses using Agilent SureSelect Human All Exon Kits in a multiplex Chinese DUH family to identify the pathogenic mutations and verified the candidate mutations using Sanger sequencing. Quantitative RT-PCR and Immunohistochemistry was performed to verify the expression of the pathogenic gene, Zebrafish was also used to confirm the functional role of ABCB6 in melanocytes and pigmentation.Genome-wide linkage (assuming autosomal dominant inheritance mode and exome sequencing analyses identified ABCB6 as the disease candidate gene by discovering a coding mutation (c.1358C>T; p.Ala453Val that co-segregates with the disease phenotype. Further mutation analysis of ABCB6 in four other DUH families and two sporadic cases by Sanger sequencing confirmed the mutation (c.1358C>T; p.Ala453Val and discovered a second, co-segregating coding mutation (c.964A>C; p.Ser322Lys in one of the four families. Both mutations were heterozygous in DUH patients and not present in the 1000 Genome Project and dbSNP database as well as 1,516 unrelated Chinese healthy controls. Expression analysis in human skin and mutagenesis interrogation in zebrafish confirmed the functional role of ABCB6 in melanocytes and pigmentation. Given the involvement of ABCB6 mutations in coloboma, we performed ophthalmological examination of the DUH carriers of ABCB6 mutations and found ocular abnormalities in them.Our study has advanced our understanding of DUH pathogenesis and revealed the shared pathological mechanism between pigmentary DUH and ocular coloboma.

  3. O cemitério como espaço devocional: um estudo sobre a devoção a Irmã Benigna (The cemetery as devotional space: a study about the devotion to sister Benigna

    Directory of Open Access Journals (Sweden)

    Ilza Mara Lima

    2013-03-01

    Full Text Available Este artigo pretende analisar os cemitérios como espaço de múltiplas devoções, dentre elas as devoções marginais: as diversas formas com as quais as pessoas cultuam seus mortos, através de seus túmulos. As devoções que são manifestadas perante esses túmulos dentro dos cemitérios demonstram esta prática de fé, que se denomina de devoção marginal. Pessoas comuns que após a morte, ganham a veneração de fieis que lhe pedem a interseção junto ao sagrado, são cultuadas como milagreiras.  Após o pedido realizado, o devoto passa há ornamentar o tumulo do Milagreiro, com Flores, Velas, Ex votos em forma de agradecimento. O túmulo então se torna objeto de veneração e peregrinação. O artigo examina como esta devoção no cemitério do Bonfim, em Belo Horizonte, mais especificamente no túmulo da milagreira Irmã Benigna, auxilia os devotos nos momentos de suas angústias e aflições. Analisa-se como essa devoção se perpetua à margem da crença oficial. Palavras-chave: Morte. Enterramento. Túmulo. Devoção. Irmã Benigna.   Abstract This article analyzes the cemeteries as a place of many devotions, devotions among them marginal. the various ways in which people worship their dead through their graves. The devotions that are manifested before these graves within the cemeteries demonstrate the practice of faith is called the marginal devotion. Ordinary people who are worshiped as a miracle worker. The article examines how this devotion in the cemetery of Bonfim in Belo Horizonte City, more specifically in the miraculous Num Benigna’s Tomb helps the devotees by the time their distress happene. It looks at how devotion is perpetuated the margin of the official belief. Keywords: Death. Burial. Grave. Devotion. Nun Benigna’s. 

  4. Hematuria and clot retention after transvaginal oocyte aspiration: a case report.

    Science.gov (United States)

    Modder, Joshua; Kettel, L Michael; Sakamoto, Kyoko

    2006-09-01

    To report a case of bladder injury with hematuria and urinary retention after transvaginal oocyte aspiration. Case report. Emergency room in a university medical center. A 28-year-old woman presented with urinary retention and suprapubic pain 8 hours after oocyte aspiration. Foley catheter, intravenous fluid bolus, bladder irrigation, and computed tomography with postvoid films that showed a blood clot in the bladder. Patient was discharged home with antibiotics and catheter in place. Clinical follow-up. Patient passed voiding trial 4 days later and was artificially inseminated. No further hematuria or voiding problems were reported, and she had a successful pregnancy. Patients who elect to undergo oocyte aspiration should be warned about the possibility of bladder injury because of the close proximity of the ovaries to the bladder, and physicians should have an appropriate treatment plan.

  5. Severe hematuria after transurethral electrocoagulation in a patient with an arteriovesical fistula.

    Science.gov (United States)

    Zheng, Xiangyi; Lin, Yiwei; Chen, Bin; Zhou, Xianyong; Zhou, Xiaofeng; Shen, Yuehong; Xie, Liping

    2013-12-01

    Arteriovesical fistulas are extremely rare. Only eleven cases were previously reported in the literature. They can occur iatrogenically, traumatically or spontaneously. We report an unusual case of a 62-year-old woman with arteriovesical fistula that developed fatal hematuria after transurethral electrocoagulation. Computed tomography (CT) and selective angiography revealed a pseudoaneurysm of the right superior vesical artery with arteriovesical fistula formation, which was managed by transarterial embolization. Contrast enhanced CT or CT angiography should be performed when a pulsatile hemorrhage is revealed during cystoscopy. Therapeutic vesical arterial embolization should be considered as a safe and effective procedure for arteriovesical fistulas. Transurethral electrocoagulation may cause severe hematuria for pulsatile bladder bleeding in patients with pelvic vascular malformation.

  6. Small cell carcinoma of the urinary bladder without gross hematuria: a case report.

    Science.gov (United States)

    Huang, Wanqiu; Luan, Yang; Jin, Lu; Wang, Tao; Chen, Ruibao; Liu, Zheng; Chen, Zhiqiang; Lan, Ruzhu

    2015-09-01

    Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancer with poor prognosis. Hematuria is the main symptom of this malignancy, and most patients have a history of smoking. The disease incidence of malignant bladder tumors in China is approximately 0.74%. Early and accurate diagnosis of SCCB can ensure timely and appropriate treatment of this malignant disease. Oncologic surgery is the standard treatment; however, it may not be a curative approach. Chemotherapy and/or radiotherapy should be performed following surgical removal. This case report describes a patient with a single neoplasm diagnosed as SCCB that arose because of recurrence of bladder cancer after bladder tumor resection. In contrast to previously reported cases, this patient had no gross hematuria and no history of smoking.

  7. Arterioureteral Fistula: Treatment of a Hemorrhagic Shock with Massive Hematuria by Placing a Balloon Catheter

    Science.gov (United States)

    Riquet, Hervé; Nicolacopoulos, Ioannis; Alame, Abbas

    2017-01-01

    Arterioureteral fistulas (AUF) are serious diseases with increasing incidence. This case report relates the management of AUF in a patient with a history of abdominal oncological surgery, pelvic radiotherapy, and a double J stent in place. The fistula was discovered during a hemorrhagic shock with massive hematuria. The bleeding was controlled by a balloon catheter which led to endovascular treatment consisting of a covered stent. PMID:28465857

  8. Arterioureteral Fistula: Treatment of a Hemorrhagic Shock with Massive Hematuria by Placing a Balloon Catheter

    Directory of Open Access Journals (Sweden)

    Nicolas Merzeau

    2017-01-01

    Full Text Available Arterioureteral fistulas (AUF are serious diseases with increasing incidence. This case report relates the management of AUF in a patient with a history of abdominal oncological surgery, pelvic radiotherapy, and a double J stent in place. The fistula was discovered during a hemorrhagic shock with massive hematuria. The bleeding was controlled by a balloon catheter which led to endovascular treatment consisting of a covered stent.

  9. Hematuria renal idiopática: reporte de un caso clínico

    Directory of Open Access Journals (Sweden)

    María A. Serna Valencia

    2008-12-01

    Full Text Available Se describe un caso de hematuria renal idiopática en un canino de la raza Mastín Napolitano de 7,5 años de edad, presentado a consulta por hematuria con varios meses de evolución; los análisis de sangre, orina y las ayudas de imagenología (radiografía y ecografía no fueron suficientes para indicar un diagnóstico. Se recomendó la celiotomía exploratoria y, después de cateterizar los uréteres desde el interior de la vejiga, se estableció que el sangrado provenía del riñón derecho, el cual fue extirpado con su uréter. Se realizaron exámenes de histopatología del riñón extirpado, encontrándose nefrosis y un proceso degenerativo generalizado a nivel de corteza y médula renal. La hematuria no se resolvió en el postoperatorio, seguramente por ser de origen bilateral; el paciente murió de otra causa no relacionada, y no fue posible evaluar el riñón contralateral.

  10. Utility of urine cytology in evaluating hematuria with sonographically suspected bladder lesion in patients older than 50 years

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    Hussam Eldin Helmy Mady

    2014-01-01

    Conclusion: Hematuria in patients older than 50 years with sonographically suspected bladder lesion mandates cystoscopy and biopsy. UC does not add more significant information in this group of patients.

  11. Esferocitosis hereditaria: de la biogénesis a la patogénesis Hereditary spherocytosis: from biogenesis to pathogenesis

    Directory of Open Access Journals (Sweden)

    Heidys Garrote-Santana

    2012-12-01

    Full Text Available La esferocitosis hereditaria es la anemia hemolítica congénita más frecuente en la población caucásica. Tiene una amplia variabilidad clínica y desde el punto de vista hematológico se caracteriza por anemia y presencia de esferocitos en la lámina periférica. Su base fisiopatológica está determinada por el defecto de algunas de las proteínas que conforman la membrana eritrocitaria, por el efecto del bazo sobre los hematíes anómalos y otros factores. A la luz de los conocimientos actuales, la interpretación dinámica del proceso requiere adentrarse en los estadios iniciales de la hematopoyesis, pues desde etapas tan tempranas como la enucleación del eritroblasto en la formación del reticulocito, hasta posibles procesos inflamatorios tardíos, pudieran modular la expresión de la enfermedad. Se hace una revisión de las características estructurales y funcionales de la membrana eritrocitaria, así como algunos aspectos generales de las propiedades del hematíe para facilitar la comprensión de los eventos que tienen lugar a partir del compromiso molecular de las proteínas que conforman la membrana.Hereditary spherocytosis is the most common congenital hemolytic anemia among Caucasian population. It has wide clinical variety and from the haematological point of view, it is characterized by the presence of spherocytes anemia in peripheral lamina. Its pathophysiological defect is determined by some of the proteins that make up the red cell membrane due to the effect on erythrocytes of abnormal spleen, and other factors. In view of current knowledge, the dynamic interpretation of this process requires delving into the early stages of hematopoiesis, since the expression of this disease could modulate from early stages of erythroblast enucleation in reticulocyte formation until late potential inflammatory processes. A review was made on the structural and functional characteristics of the erythrocyte membrane, as well as some general

  12. Esferocitosis hereditaria: aspectos clínicos, bioquímicos y moleculares Hereditary spherocytosis: Clinical, biochemical and molecular aspects

    Directory of Open Access Journals (Sweden)

    Mayelín Herrera García

    2002-04-01

    Full Text Available La esferocitosis hereditaria (EH es una enfermedad caracterizada por anemia hemolítica de severidad variable, con presencia de esferocitos en sangre periférica y una respuesta clínica favorable a la esplenectomía. Con el desarrollo de nuevas técnicas se encontraron las primeras alteraciones bioquímicas de las proteínas de la membrana eritrocitaria, y posteriormente, se han podido precisar las alteraciones moleculares mediante las técnicas del ADN recombinante. La EH es una enfermedad muy heterogénea que se produce por un defecto intrínseco del glóbulo rojo, y existen otras alteraciones secundarias a esta afección. La prueba más utilizada para el diagnóstico de la EH es la fragilidad osmótica del glóbulo rojo. Se ha demostrado que esta enfermedad es producida por defectos de las proteínas que intervienen en las interacciones verticales entre el esqueleto de la membrana y la bicapa lipídica. El tratamiento de elección en la EH es la esplenectomía, ya que es el más efectivo en el control de la anemia, aunque la sobrevida de los glóbulos rojos permanece acortada y los esferocitos no desaparecen. Este proceder se indica en pacientes con anemia hemolítica severa o en individuos moderadamente asintomáticos pero que presentan litiasis vesicularHereditary spherocytosis(HS is a disease characterized by hemolytic anemia of variable severity, with spherocytes in peripheral blood and a clinical response to splenectomy. The development of new techniques allowed finding out the first biochemical alterations in erythrocyte membrane proteins and later on, the recombinant DNA techniques made possible to detect molecular alternations. HS is a very heterogeneous disease caused by an intrinsic defect of red cells; there are other secondary disorders to this affection. The most used test for diagnosing HS is the osmotic fragility of the red cell. It has been proved that this disease is caused by defects in proteins participating in vertical

  13. Association between arsenic exposure from drinking water and hematuria: Results from the Health Effects of Arsenic Longitudinal Study

    International Nuclear Information System (INIS)

    McClintock, Tyler R.; Chen, Yu; Parvez, Faruque; Makarov, Danil V.; Ge, Wenzhen; Islam, Tariqul; Ahmed, Alauddin; Rakibuz-Zaman, Muhammad; Hasan, Rabiul; Sarwar, Golam; Slavkovich, Vesna; Bjurlin, Marc A.; Graziano, Joseph H.

    2014-01-01

    Arsenic (As) exposure has been associated with both urologic malignancy and renal dysfunction; however, its association with hematuria is unknown. We evaluated the association between drinking water As exposure and hematuria in 7843 men enrolled in the Health Effects of Arsenic Longitudinal Study (HEALS). Cross-sectional analysis of baseline data was conducted with As exposure assessed in both well water and urinary As measurements, while hematuria was measured using urine dipstick. Prospective analyses with Cox proportional regression models were based on urinary As and dipstick measurements obtained biannually since baseline up to six years. At baseline, urinary As was significantly related to prevalence of hematuria (P-trend < 0.01), with increasing quintiles of exposure corresponding with respective prevalence odds ratios of 1.00 (reference), 1.29 (95% CI: 1.04–1.59), 1.41 (95% CI: 1.15–1.74), 1.46 (95% CI: 1.19–1.79), and 1.56 (95% CI: 1.27–1.91). Compared to those with relatively little absolute urinary As change during follow-up (− 10.40 to 41.17 μg/l), hazard ratios for hematuria were 0.99 (95% CI: 0.80–1.22) and 0.80 (95% CI: 0.65–0.99) for those whose urinary As decreased by > 47.49 μg/l and 10.87 to 47.49 μg/l since last visit, respectively, and 1.17 (95% CI: 0.94–1.45) and 1.36 (95% CI: 1.10–1.66) for those with between-visit increases of 10.40 to 41.17 μg/l and > 41.17 μg/l, respectively. These data indicate a positive association of As exposure with both prevalence and incidence of dipstick hematuria. This exposure effect appears modifiable by relatively short-term changes in drinking water As. - Highlights: • Hematuria is the most common symptom of urinary tract disease. • Arsenic exposure is associated with renal dysfunction and urologic malignancy. • Water arsenic was positively associated with prevalence and incidence of hematuria. • Reduction in exposure lowered hematuria risk especially in low-to-moderate exposed

  14. Association between arsenic exposure from drinking water and hematuria: Results from the Health Effects of Arsenic Longitudinal Study

    Energy Technology Data Exchange (ETDEWEB)

    McClintock, Tyler R. [Department of Population Health, New York University School of Medicine, New York, NY (United States); Department of Environmental Medicine, New York University School of Medicine, New York, NY (United States); Department of Urology, New York University School of Medicine, New York, NY (United States); Chen, Yu, E-mail: yu.chen@nyumc.org [Department of Population Health, New York University School of Medicine, New York, NY (United States); Department of Environmental Medicine, New York University School of Medicine, New York, NY (United States); Parvez, Faruque [Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY (United States); Makarov, Danil V. [Department of Urology, New York University School of Medicine, New York, NY (United States); Robert F. Wagner Graduate School of Public Service, New York University, New York, NY (United States); United States Department of Veterans Affairs Harbor Healthcare System, New York, NY (United States); New York University Cancer Institute, New York, NY (United States); Ge, Wenzhen [Department of Population Health, New York University School of Medicine, New York, NY (United States); Department of Environmental Medicine, New York University School of Medicine, New York, NY (United States); Islam, Tariqul; Ahmed, Alauddin; Rakibuz-Zaman, Muhammad; Hasan, Rabiul; Sarwar, Golam [U-Chicago Research Bangladesh, Ltd., Dhaka (Bangladesh); Slavkovich, Vesna [Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY (United States); Bjurlin, Marc A. [Department of Urology, New York University School of Medicine, New York, NY (United States); Graziano, Joseph H. [Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY (United States); and others

    2014-04-01

    Arsenic (As) exposure has been associated with both urologic malignancy and renal dysfunction; however, its association with hematuria is unknown. We evaluated the association between drinking water As exposure and hematuria in 7843 men enrolled in the Health Effects of Arsenic Longitudinal Study (HEALS). Cross-sectional analysis of baseline data was conducted with As exposure assessed in both well water and urinary As measurements, while hematuria was measured using urine dipstick. Prospective analyses with Cox proportional regression models were based on urinary As and dipstick measurements obtained biannually since baseline up to six years. At baseline, urinary As was significantly related to prevalence of hematuria (P-trend < 0.01), with increasing quintiles of exposure corresponding with respective prevalence odds ratios of 1.00 (reference), 1.29 (95% CI: 1.04–1.59), 1.41 (95% CI: 1.15–1.74), 1.46 (95% CI: 1.19–1.79), and 1.56 (95% CI: 1.27–1.91). Compared to those with relatively little absolute urinary As change during follow-up (− 10.40 to 41.17 μg/l), hazard ratios for hematuria were 0.99 (95% CI: 0.80–1.22) and 0.80 (95% CI: 0.65–0.99) for those whose urinary As decreased by > 47.49 μg/l and 10.87 to 47.49 μg/l since last visit, respectively, and 1.17 (95% CI: 0.94–1.45) and 1.36 (95% CI: 1.10–1.66) for those with between-visit increases of 10.40 to 41.17 μg/l and > 41.17 μg/l, respectively. These data indicate a positive association of As exposure with both prevalence and incidence of dipstick hematuria. This exposure effect appears modifiable by relatively short-term changes in drinking water As. - Highlights: • Hematuria is the most common symptom of urinary tract disease. • Arsenic exposure is associated with renal dysfunction and urologic malignancy. • Water arsenic was positively associated with prevalence and incidence of hematuria. • Reduction in exposure lowered hematuria risk especially in low-to-moderate exposed

  15. Evaluation of an Epigenetic Profile for the Detection of Bladder Cancer in Patients with Hematuria.

    Science.gov (United States)

    van Kessel, Kim E M; Van Neste, Leander; Lurkin, Irene; Zwarthoff, Ellen C; Van Criekinge, Wim

    2016-03-01

    Many patients enter the care cycle with gross or microscopic hematuria and undergo cystoscopy to rule out bladder cancer. Sensitivity of this invasive examination is limited, leaving many patients at risk for undetected cancer. To improve current clinical practice more sensitive and noninvasive screening methods should be applied. A total of 154 urine samples were collected from patients with hematuria, including 80 without and 74 with bladder cancer. DNA from cells in the urine was epigenetically profiled using 2 independent assays. Methylation specific polymerase chain reaction was performed on TWIST1. SNaPshot™ methylation analysis was done for different loci of OTX1 and ONECUT2. Additionally all samples were analyzed for mutation status of TERT (telomerase reverse transcriptase), PIK3CA, FGFR3 (fibroblast growth factor receptor 3), HRAS, KRAS and NRAS. The combination of TWIST1, ONECUT2 (2 loci) and OTX1 resulted in the best overall performing panel. Logistic regression analysis on these methylation markers, mutation status of FGFR3, TERT and HRAS, and patient age resulted in an accurate model with 97% sensitivity, 83% specificity and an AUC of 0.93 (95% CI 0.88-0.98). Internal validation led to an optimism corrected AUC of 0.92. With an estimated bladder cancer prevalence of 5% to 10% in a hematuria cohort the assay resulted in a 99.6% to 99.9% negative predictive value. Epigenetic profiling using TWIST1, ONECUT2 and OTX1 results in a high sensitivity and specificity. Accurate risk prediction might result in less extensive and invasive examination of patients at low risk, thereby reducing unnecessary patient burden and health care costs. Copyright © 2016 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  16. The use of molecular analyses in voided urine for the assessment of patients with hematuria

    DEFF Research Database (Denmark)

    Beukers, Willemien; Kandimalla, Raju; van Houwelingen, Diandra

    2013-01-01

    variables into a logistic regression model. Results Logistic regression analysis based on the five methylation markers, age, gender and type of hematuria resulted in an area under the curve (AUC) of 0.88 and an optimism corrected AUC of 0.84 after internal validation by bootstrapping. Using a cut-off value...... examination of low risk patients and thereby, reducing patient burden and costs. Further validation in a large prospective patient cohort is necessary to prove the true clinical value of this model....

  17. [Placenta percreta with bladder invasion: an uncommon cause of hematuria during pregnancy].

    Science.gov (United States)

    Sierra-Solís, A; Leo-Barahona, M; Romero-López, A I; Gómez-Guerrero, J M

    2014-01-01

    Placenta percreta with bladder invasion is a very uncommon condition that can lead to very severe complications in pregnant women. Although it is often diagnosed during delivery, imaging techniques are very useful for early diagnosis, which is fundamental for planning surgery and avoiding potentially lethal complications. We present the case of a woman with a history of cesarean section who presented with hematuria and low back pain. The diagnosis of placenta percreta with bladder invasion was suggested after ultrasonography and magnetic resonance imaging and was confirmed at surgery. We provide a brief review of the literature, emphasizing the role of imaging techniques. Copyright © 2012 SERAM. Published by Elsevier Espana. All rights reserved.

  18. La anamnesis y el examen físico en el estudio genético clínico de las sorderas hereditarias

    Directory of Open Access Journals (Sweden)

    Estela Morales Peralta

    2004-06-01

    Full Text Available Los avances científicos ocurridos en los últimos años ponen a disposición de la medicina, de adelantos tecnológicos que han hecho que algunos planteen que el método clínico está en peligro. En este trabajo se hace un análisis sobre la utilidad del interrogatorio y el examen físico como herramientas útiles para el genetista clínico en el estudio de las sorderas hereditarias.The scientific advances occurred in the last years put at the disposal of medicine technological advances that have made some think that the clinical method is in danger. An analysis is made on the usefulness of the questionnaire and the physical examination as appropriate tools for the clinical geneticist in the study of hereditary deafness.

  19. Atrofia óptica hereditaria autosómica dominante: A propósito de una familia Dominant autosomal hereditary optical atrophy: Apropos of a family

    Directory of Open Access Journals (Sweden)

    Noel Taboada Lugo

    2004-12-01

    Full Text Available Entre las causas de pérdida insidiosa, bilateral y simétrica de la visión central se deben tener siempre presente las atrofias ópticas heredo degenerativas. La atrofia óptica hereditaria autosómica dominante es la forma más frecuente de atrofia óptica heredofamiliar simple o monosintomática. Se realizó la caracterización clínica de una familia con el diagnóstico de esta discapacidad visual.Among the causes of insidious, bilateral and symmetric loss of the central vision, the hereditary and degenerative optical atrophies should always be taken into account. The dominant autosomal hereditary optical atrophy is the most frequent form of simple or monosymptomatic hereditary family optical atrophy. The clinical characterization of a family with the diagnosis of this visual impairment was made.

  20. Las Nuevas Tecnologías en el Tratamiento de la Hipertrofia Benigna de la Próstata

    Directory of Open Access Journals (Sweden)

    Pablo Gómez Martinez

    1993-08-01

    Full Text Available

    Hace unas cuantas semanas apareció en la prensa de la capital una página dedicada a “un nuevo tratamiento de la hipertrofia benigna de la próstata, sin necesidad de operación”, noticia que, naturalmente, despertó un gran interés entre los afectados por esta enfermedad, con la esperanza de librarse de las intervenciones quirúrgica…, clásicas: la prostatectomía a cielo abierto, o la prostatectomía transuretral.

    El despliegue publicitario fue aprovechado por un pequeño grupo de urólogos (olvidándose un poco de la ética profesional para anunciar la adquisición del aparato y ofrecer los servicios al público de esta nueva tecnología, que el cronista anunció como la panacea para curar la enfermedad, sin recurrir a la cirugía y que han continuado promoviendo a través de la televisión.

    Como era de esperarse, los enfermos comenzaron a consultar a sus médicos sobre la bondad y eficacia del nuevo tratamiento.

    Es un hecho que la mayoría de los profesionales no está muy al corriente del método para poder dar un consejo acertado e imparcial. Hemos considerado importante transmitir la información, de manera’ sucinta, sobre la.’, bases del método, su efecto sobre los tejidos, sus indicaciones y contraindicaciones y los resultados obtenidos.

    El tratamiento se basa en la aplicación del calor a través del recto o de la uretra, generado por medio de micro-ondas, y no es otra cosa que una modalidad de termoterapia...

  1. Massive hematuria due to a congenital renal arteriovenous malformation mimicking a renal pelvis tumor: a case report

    Directory of Open Access Journals (Sweden)

    Sountoulides P

    2008-05-01

    Full Text Available Abstract Introduction Congenital renal arteriovenous malformations (AVMs are very rare benign lesions. They are more common in women and rarely manifest in elderly people. In some cases they present with massive hematuria. Contemporary treatment consists of transcatheter selective arterial embolization which leads to resolution of the hematuria whilst preserving renal parenchyma. Case presentation A 72-year-old man, who was heavy smoker, presented with massive hematuria and flank pain. CT scan revealed a filling defect caused by a soft tissue mass in the renal pelvis, which initially led to the suspicion of a transitional cell carcinoma (TCC of the upper tract, in view of the patient's age and smoking habits. However a subsequent retrograde study could not depict any filling defect in the renal pelvis. Selective right renal arteriography confirmed the presence of a renal AVM by demonstrating abnormal arterial communication with a vein with early visualization of the venous system. At the same time successful selective transcatheter embolization of the lesion was performed. Conclusion This case highlights the importance of careful diagnostic work-up in the evaluation of upper tract hematuria. In the case presented, a congenital renal AVM proved to be the cause of massive upper tract hematuria and flank pain in spite of the initial evidence indicating the likely diagnosis of a renal pelvis tumor.

  2. Effect of tranexamic acid on gross hematuria: A pilot randomized clinical trial study.

    Science.gov (United States)

    Moharamzadeh, Payman; Ojaghihaghighi, Seyedhossein; Amjadi, Mohsen; Rahmani, Farzad; Farjamnia, Arezoo

    2017-12-01

    Local forms of the tranexamic acid have been effective in treating many haemorrhagic cases. So that the aim of the current study is to assess the effectiveness of local tranexamic acid in controlling painless hematuria in patients referred to the emergency department. This is a randomized, double-blind clinical trial study, which was conducted on 50 patients with complaints of painless lower urinary tract bleeding during June 2014 and August 2015. The patients were randomly divided into two groups of 25 people each, one group receiving tranexamic acid and the other given a placebo. During bladder irrigation, local tranexamic acid and the placebo were injected into the bladder via Foley catheter. Patients were examined over 24h in terms of the amount of normal saline serum used for irrigation, level of hemoglobin, and blood in urine. In this study it was observed that consumption of tranexamic acid significantly decreased the volume of used serum for bladder irrigation (P=0.041) and the microscopic status of urine decreased significantly in terms of the hematuria after 24h (P=0.026). However, the rate of packed cell transfusion and drop in hemoglobin levels showed no significant difference in both groups of patients (P˃0.05). The results of this study showed that tranexamic acid could significantly reduce the volume of required serum for bladder irrigation to clear urine, but it had no significant effect on the drop in serum hemoglobin levels. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. [Psychogenic purpura with hematuria and sexual pain disorder: a case report].

    Science.gov (United States)

    Ozyildirim, Ilker; Yücel, Başak; Aktan, Melih

    2010-01-01

    Psychogenic purpura (Gardner-Diamond syndrome) is the occurrence and spontaneous recurrence of painful ecchymosis following emotional stress and minor trauma. Although the exact mechanism of this syndrome remains unknown, apart from skin lesions, different types of hemorrhaging have been reported, such as epistaxis, gastrointestinal bleeding, and bleeding from the ear canals and eyes. We report a psychogenic purpura case that presented with hematuria in addition to skin lesions. Based on the psychiatric evaluation she was diagnosed with major depressive disorder, generalized anxiety disorder, and obsessive-compulsive disorder. Additionally, sexual pain disorder accompanied these disorders. With the help of antidepressant and supportive psychotherapy, the patient's ecchymosis and bleeding disappeared. During 8 months of follow-up the symptoms did not return. Vaginismus has not been reported in patients with psychogenic purpura. The presence of vaginismus, which is seen more frequently in eastern cultures and is thought to be related to sociocultural determinants, suggests that some cultural factors may be common to both psychogenic purpura and vaginismus. The aim of this case report was to call attention to a syndrome that is rarely seen and diagnosed, and to discuss its relationship to psychosocial factors. This syndrome should be considered in the differential diagnosis of not only ecchymotic lesions, but also various types of bleeding, including hematuria. Despite the fact that its etiology and treatment are not clearly understood, it should be noted that psychological factors play a role in this disease and therefore, psychopharmacological and psychotherapeutic approaches can be effective.

  4. Inserción de prótesis metálicas autoexpandibles totalmente recubiertas en patología biliar benigna

    Directory of Open Access Journals (Sweden)

    Mariana Omodeo

    Full Text Available RESUMEN Introducción: las enfermedades biliares benignas se han tratado, tradicionalmente, mediante la colocación de prótesis plásticas. Sin embargo, en la actualidad, las prótesis metálicas autoexpandibles totalmente recubiertas están ganando aceptación para el tratamiento de dichas patologías. Objetivo: evaluar la eficacia y las complicaciones de la inserción endoscópica temporal de prótesis metálicas totalmente recubiertas para el tratamiento de patologías biliares benignas. Materiales y métodos: estudio retrospectivo y observacional realizado a partir de una base de datos prospectiva en un centro de tercer nivel entre marzo de 2012 y mayo de 2016. Se incluyeron pacientes a los que se les colocó una prótesis metálica totalmente recubierta por patología benigna de la vía biliar. Se documentaron las indicaciones, las tasas de resolución, las de éxito técnico y los eventos adversos. Resultados: se incluyeron 31 pacientes a los que se insertaron 34 prótesis. Las indicaciones fueron las siguientes: 8 (25% estenosis biliares poscolecistectomía, 11 (31% coledocolitiasis de gran tamaño o múltiple, 3 (8,3% fístulas biliares, 2 (6% estenosis postrasplante hepático, 3 (8,3% estenosis papilares, 2 (6% perforaciones y 2 (6% sangrados. La tasa de éxito global de resolución de la patológica fue del 88%: 87,5% (7/8 en estenosis poscolecistectomía, 73% (8/11 en litiasis gigante, y 100% en el resto de las indicaciones. Se retiraron mediante endoscopia 33 de las 34 tras un promedio de 133 días (rango 10-180 días. No se registraron complicaciones. Conclusión: las prótesis metálicas autoexpandibles totalmente recubiertas son una alternativa efectiva y segura en la resolución de patologías biliares benignas.

  5. Detección y tipificación de virus del papiloma humano en biopsias de carcinoma ductal infiltrante y lesiones benignas de mama en mujeres venezolanas

    OpenAIRE

    Solorzano, Marisé; Bastidas, Marco; Quintero, Militza; Rojas, Lisbeth; Stea, Domingo; Villasmil, Saúl; Acosta, Víctor; Marín, Carmen; Ramírez, Ana; Blanco, Natasha; Cruz, Jhon; Puig, Juan

    2016-01-01

    Objetivo: Realizar la detección y tipificación del virus del papiloma humano (VPH) en muestras de biopsias de tejido mamario con carcinoma ductal infiltrante. Métodos: Estudio descriptivo de corte transversal de 57 biopsias de carcinoma ductal infiltrante, y 41 biopsias de lesiones benignas de mama de pacientes venezolanas, estas fueron evaluadas utilizando la técnica PCR-RFLP en busca de la presencia del genoma del virus de papiloma humano. El riesgo OR fue evaluado mediante análisis estadís...

  6. The changing scene of radiology: Value of urography as initial examination in infectious and hypertensive disease, hematuria and malignant disease

    International Nuclear Information System (INIS)

    Goethlin, J.H.; Gadeholt, G.; Hoeiem, L.; Aslaksen, A.

    1988-01-01

    Four to 20% positive findings were found in a review of 1913 excretory urographics. Possibly relevant findings were 20% in patients referred for infectious disease, 10% in hypertensive disease, 6% in hematuria and 4% in neoplasms. Urography influenced treatment mainly in the 2 groups with few positive findings. The costs for positive findings may be acceptable in patients with hematuria or suspicion of neoplasms, but are too high in the other groups. Until ultrasonography can replace intravenous urography as the first screening method in upper urinary tract disease, the patient selection for urography in infectious and hypertensive disease should be improved. (orig.)

  7. Quedas em idosos com Vertigem Posicional Paroxística Benigna Elderly falls associated with benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    Fernando Freitas Ganança

    2010-02-01

    Full Text Available Vertigem Posicional Paroxística Benigna (VPPB pode causar quedas, principalmente em pacientes idosos. OBJETIVO: Verificar se o número de quedas em idosos com VPPB diminui após a realização de manobras de reposicionamento de partículas (MRP. MATERIAL E MÉTODO: Estudo retrospectivo em que foram incluídos idosos com VPPB que tenham apresentado queda no último ano. Todos os pacientes submeteram-se à MRP de acordo com o canal semicircular (CSC acometido. Após a abolição da vertigem e do nistagmo de posicionamento, os pacientes foram acompanhados ao longo de 12 meses e investigados em relação ao número de quedas neste período. Para comparar o número de quedas antes e após as MRP utilizou-se avaliação estatística por meio do teste de Wilcoxon. RESULTADOS: Foram incluídos 121 pacientes. Cento e um pacientes apresentaram acometimento do CSC posterior, 16 do lateral e quatro do anterior. Verificou-se redução do número de quedas após as MRP, com diferença estatisticamente significante na amostra geral (pBenign Paroxysmal Positional Vertigo (BPPV can cause falls, especially in the elderly. AIM: to study whether or not elderly patients with BPPV have a reduction on their falls after the particle repositioning maneuver (PRM. MATERIALS AND METHODS: retrospective study including elderly with BPPV who had fall(s during the last year. All patients were submitted to the PRM according to the affected semicircular canal (SCC. After the abolition of positioning vertigo and nystagmus, the patients were submitted to a 12 month follow-up and were investigated about the number of fall(s. Wilcoxon's test was performed to compare the number of fall(s before and after 12 months of the PRM. RESULTS: One hundred and twenty one patients were included in the study. One hundred and one patients presented involvement of the posterior SCC, 16 of the lateral and four of the anterior. We noticed a reduction on the number of falls, with statistically

  8. Comparison of CT urography and intravenous urography in patients with hematuria

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Guen Young; Kang, Byung Chul; Hwang, Ji Young [Ewha Womans University College of Medicine, Seoul (Korea, Republic of)

    2006-12-15

    We wanted to compare CT urography (CTU) with using multi-detector row CT (MDCT) and intravenous urography (IVU) for diagnosing the causes of hematuria. From January 2003 to March 2004, IVU and CTU were obtained in 48 patients. We evaluated the causes of hematuria in 34 of 48 patients. The IVU images were obtained by the conventional method. The CTU images were routinely obtained before intravenous contrast injection, and at 2 and 5 minutes after intravenous contrast injection. In case of delayed excretion of contrast by the kidneys, the delayed CT scans were obtained at 120 minutes after contrast injection. All the CT images, including the axial and 3D coronal reformatted CTUs with using software as well as conventional IVU images, were reviewed by two radiologists working in consensus. We decided if urinary stone existed or not and we looked for the indirect signs such as hydronephrosis or delayed excretion, etc. We also observed if it was possible to determine the mass, ureteral stricture and enhancement of the ureteral wall, etc. We calculated sensitivity, specificity, positive predictive value and negative predictive value for each modality to diagnose urinary stone. We compared the detection rate according to the phases of CTU. We confirmed the presence of urinary tract stones in 27 of 34 patients who had undergone both IVU and CTU. We diagnosed ureteritis in 1, transitional cell carcinoma in 5 and acute pyelonephritis in 1 of the remaining 7 patients. The urinary stones were detected in fifteen patients on both IVU and CTU (15/27, 55.6%). We detected the urinary stones on CTU, but not IVU, in twelve patients (12/27, 44.5%). The sensitivity to detect the urinary stones was 100% (27/27) on CTU and 55.6% (12/27) on IVU respectively. The specificity was 100% (7/7) on IVU and CTU, respectively. The positive predictive value was 100% (15/15) on IVU and 100% (27/27) on CTU, respectively. The negative predictive value was 36.8% (7/19) on IVU and 100% (7/7) on CTU

  9. Microscopic or occult hematuria, when reflex testing is not good laboratory practice.

    Science.gov (United States)

    Froom, Paul; Barak, Mira

    2010-01-01

    Consensus opinion suggests that hematuria found by dipstick and not confirmed on microscopic examination (<2 erythrocytes per high power field) signifies a false-positive reagent strip test result. Standard practice is to repeat the dipstick test several days later and if still positive to confirm by microscopic examination. If discordant results are obtained, experts recommend reflex testing for urinary myoglobin and hemoglobin concentrations. The question is whether or not this approach represents good laboratory practice. These recommendations are not evidence based. We conclude that the reference range for red blood cells on the reagent strip should be increased to 25x10(6) cells/L for young men, and 50x10(6) cells/L for the rest of the adult population, ranges consistent with flow cytometry reports. Confirmation reflex testing using tests that have inferior sensitivity, precision and probably accuracy is not recommended.

  10. Síndrome de Brown bilateral associada com hipermobilidade articular benigna: relato de caso Bilateral Brown's syndrome associated with benign joint hypermobility: a case report

    Directory of Open Access Journals (Sweden)

    David Kirsch

    2007-03-01

    Full Text Available A síndrome de Brown é caracterizada por grande limitação de elevação em adução, elevação ligeiramente diminuída ou normal na abdução, anisotropia em "Y" ou "V", intorção do olho em supraversão e ducção forçada positiva. Sua causa se deve à inelastibilidade do músculo oblíquo superior ou por sua contenção em sua própria bainha. A hipermobilidade articular benigna é doença hereditária do tecido conectivo caracterizada por aumento da mobilidade em diversas articulações. Sua prevalência é muito variável em relação à idade, sexo e etnia, variando de 2 a 35% em homens e de 5 a 57% e mulheres. Neste relato os autores descrevem um caso de síndrome de Brown associada com hipermobilidade articular benigna e atentam para a associação pouco referida na literatura. J.C.S, masculino, 6 anos de idade, pardo, estudante, foi encaminhado à Universidade de Santo Amaro com queixa de exotropia há dois anos que aumentava na supraversão. Paciente com o diagnóstico de síndrome de Brown bilateral teve o diagnóstico de hipermobilidade articular benigna pelo Reumatologista. O paciente com hipermobilidade articular benigna pode desenvolver sintomas articulares como artralgia devido a uma inflamação articular. Acreditamos na possibilidade de que síndrome de Brown possa ter ocorrido devido a processo inflamatório na tróclea que teve início devido a hipermobilidade articular benigna.Brown's syndrome is characterized by a limitation of elevation in adduction, slight or normal limitation of elevation in abduction, divergence in straight upgaze (V-pattern, intorsion in upgaze and positive forced duction. It is caused by a tight or inelastic superior oblique tendon. Benign joint hypermobility is a hereditary disease of the connective tissue characterized by an increase of mobility in diverse joints. Its prevalence is very changeable regarding age range, sex and ethnicity, varying from 2 to 35% in men and 5 to 57% in women. In

  11. Prevalence of hypertension in healthy school children in Pakistan and its relationship with body mass index, proteinuria and hematuria

    Directory of Open Access Journals (Sweden)

    Arshalooz Jamila Rahman

    2013-01-01

    Full Text Available To determine the prevalence of high blood pressure (BP in healthy school Pakistani children and its association with high body mass index (BMI, asymptomatic hematuria and proteinuria, we studied 661 public school children and measured their body weight, height and BP and urine dipstick for hematuria performed on a single occasion. Hypertension (BP >95 th centile and pre-hypertension (BP >90 th centile were defined based on the US normative BP tables. Over-weight and obesity were defined according to the World Health Organization (WHO classification of BMI. The mean age of the children was 14 ± 1.3 years. The mean BMI was 18.5 ± 4.3 kg/m 2 . The majority (81.8% of the children were found to be normotensive (BP 25 (RR for BMI b/w 25-30 = 2.6, RR for BMI >30 = 4.3, positive urine dipstick for proteinuria (RR = 2.3 95% CI 0.7-7.7 and positive urine dipstick for hematuria (RR 1.0 95% CI 0.2-8.3. Hypertension in children is strongly correlated with obesity, asymptomatic proteinuria and hematuria. Community based screening programs for children should include BP recording, BMI assessment and urine dipsticks analysis and approach high-risk groups for early detection and lifestyle modifications.

  12. Palliative radiotherapy for hematuria complicating the local evolution of primitive bladder cancers; Radiotherapie palliative pour hematurie compliquant l'evolution locale des cancers primitifs de vessie

    Energy Technology Data Exchange (ETDEWEB)

    Saillard, S.M.; Benyoucef, A.; Dubray, B. [Centre Henri-Becquerel, 76 - Rouen (France); Smaali, C.; Albouy, B.; Pfister, C.; Grise, P. [Centre hospitalier universitaire, 76 - Rouen (France)

    2010-10-15

    As a haemostatic irradiation is often proposed to patients suffering from a primitive bladder cancer, the authors report a retrospective mono-centric analysis of the effects of an external bi-dimensional palliative radiotherapy on patients taken into care for relapsing macroscopic hematuria after failure of local urological treatments. The assessment concerns the hematuria persistence, the interval without hematuric relapse, global survival, and transfusion needs. Based on a sample of 21 patients submitted to different irradiation schemes, the authors notice that a simple pelvic irradiation technique results in a fast symptomatic improvement of hematuria among fragile patients. Short communication

  13. Histopathologic Findings of Potential Kidney Donors With Asymptomatic Microscopic Hematuria: Impact on Donation.

    Science.gov (United States)

    Hassan, E A; Ali, T Z; Abdulbaki, A; Ibrahim, I A; Almanae, H M; Aleid, H A

    2017-10-01

    Isolated microscopic hematuria (IMH) is not uncommon in potential kidney donors. The aim was to study the kidney biopsy findings of potential kidney donors with IMH and the impact of the histopathologic diagnoses on the decision to accept or decline such donors from kidney donation. In this retrospective study, all the potential kidney donors with IMH were identified from the medical records of patients who underwent kidney biopsies between January 2010 and December 2016. Forty-five such individuals were identified. The mean age of these potential donors was 32.6 years and 76% were male. All of them had normal blood pressure and no significant proteinuria. Seventeen (38%) biopsies showed histopathologic abnormalities; thin basement membrane disease (n = 13; 28%) was the most common cause followed by immunoglobulin (Ig)A nephropathy (n = 4; 9%). Donors with abnormal biopsy findings were excluded from donation. However, 62% of the potential donors had normal kidney biopsy findings and were accepted for kidney donation. IMH justifies extensive work-up including kidney biopsy to identify donors who may have underlying significant glomerular pathology excluding them from kidney donation. On the other hand, kidney biopsy also helps in accepting the donors if it does not show significant abnormality. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Efecto de una intervención de Fisioterapia en la mejora del control postural y de la marcha en la Paraparesia Espástica Hereditaria: estudio de caso

    OpenAIRE

    Siguero Jurado, Alba

    2017-01-01

    Introducción: la Paraparesia Espástica Hereditaria es trastorno neurodegenerativo poco frecuente cuyo principal síntoma es la presencia de musculatura espástica en miembros inferiores dando lugar a un trastorno lento y progresivo de la marcha. La prevalencia de esta enfermedad en España es de 9,6 casos por 100.000 habitantes. Dentro de las intervenciones de Fisioterapia, el Concepto Bobath es el más utilizado para tratar los síntomas de esta enfermedad. Objetivo: Comprobar el efecto de una...

  15. Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados

    OpenAIRE

    González del Pozo, María

    2014-01-01

    Diagnosticar genéticamente a las familias afectas de alguna de las distrofias hereditarias de retina (DHR) es, desde el punto de vista del genetista, una tarea ardua y complicada, si atendemos a la gran cantidad de genes y mutaciones reportados hasta la fecha. La gran heterogeneidad clínica y genética que caracteriza a este conjunto de enfermedades, es sin duda el mayor impedimento para su resolución genética. En este escenario, el empleo de herramientas cada vez más poderosas es indispensabl...

  16. CONCEPTOS SOBRE GENÉTICA HUMANA PARA LA COMPRENSIÓN E INTERPRETACIÓN DE LAS MUTACIONES EN CÁNCER Y OTRAS PATOLOGÍAS HEREDITARIAS

    Directory of Open Access Journals (Sweden)

    Dra. Pilar Carvallo

    2017-07-01

    Full Text Available El avance del conocimiento en la genética humana en los últimos 20 años ha sido vertiginoso y el impacto que ha tenido en la salud humana es muy relevante. Por esta razón la revisión y el conocimiento de conceptos genéticos, desde la herencia Mendeliana aplicada a la genética humana hasta las enfermedades complejas, como el cáncer y su modo de herencia, resulta imprescindible para profesionales del área de la salud. El mejor conocimiento de los genes involucrados en el inicio y la progresión del tumor, así como el tipo de herencia del cáncer y el efecto que tiene la penetrancia incompleta en el fenotipo, deben estar presentes a la hora de hacer un buen diagnóstico en cada paciente. De la misma forma, a nivel molecular es necesario saber interpretar el efect o que pueden tener las diversas variantes de la secuencia de un gen, así como el significado de variantes modificadoras del riesgo. Finalmente es importante considerar al cáncer como una patología hereditaria ya sea causada por mutaciones en un gen principal o como una enfermedad compleja causada por variantes en más de un gen y factores no genéticos. En este manuscrito se revisan todos estos conceptos con el fin de entregar una visión básica para la comprensión de las patologías con un importante componente genético.

  17. Manejo obstétrico de la deficiencia hereditaria de antitrombina durante el embarazo y puerperio. Dos casos clínicos

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    Milagros Cruz Martínez

    2015-12-01

    Full Text Available Resumen Introducción: la deficiencia de antitrombina III hereditaria es una rara enfermedad que afecta al 0.02-0.2% de la población. Puede presentar mayor frecuencia de complicaciones y resultados adversos tanto en la madre como en el feto. Se presenta el manejo obstétrico de dos gestaciones consecutivas en una mujer con deficiencia de antitrombina III. Descripción: en ambos embarazos la madre realiza profilaxis de la enfermedad tromboembólica con heparina de bajo peso molecular para evitar la aparición de esta patología tanto en el embarazo como en el puerperio y mejorar el flujo útero-placen-tario. Con respecto a las complicaciones obstétricas, sólo existe un enlentecimiento del crecimiento fetal que obliga a un control obstétrico estricto. En ambas gestaciones los estudios eco-Doppler están dentro de la normalidad lo que permite una conducta expectante, consiguiendo llegar a término. Discusión: la profilaxis con heparina de bajo peso molecular en las gestantes con esta trombofilia y las intervenciones preventivas de factores de riesgo de enfermedad tromboembólica, junto con un control obstétrico adecuado, ha conseguido evitar la apari-ción de complicaciones derivadas de esta patología en el embarazo y en el puerperio. Por otra parte, el control del crecimiento fetal y el estudio Eco-Doppler han permitido asegurar el bienestar fetal no adelan-tando el parto, consiguiendo partos a término.

  18. Selective bilateral internal iliac artery embolization for controlling refractory hematuria due to the metastatic squamous cell carcinoma of the urinary bladder: a case report

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    Gholamreza Mokhtari

    2016-09-01

    Full Text Available Bladder squamous cell carcinoma (SCC may lead to gross hematuria. However, the metastasis of head and neck cutaneous SCC to the urinary bladder has not been described in literature. Nowadays, noninvasive methods such as embolization, are considered as an appropriate choice for controlling life-threatening hematuria in patients with high operative risk. However, few reports exist on the effectiveness of this approach in managing the hematuria secondary to metastatic bladder SCC. Here we report a case of bladder SCC originating from the forehead cutaneous SCC. An 83-year-old man, a known case of forehead cutaneous SCC with distant metastasis, referred to our clinic with a chief complaint of hematuria. Pathology confirmed the diagnosis of metastatic urinary bladder SCC. Angiography and embolization were undertaken and resulted in complete alleviation of the symptoms. The recurrence of hematuria or embolization-related complications were not observed during 3-month follow-up. Selective embolization of the bilateral internal iliac artery is a safe and efficient procedure for controlling severe hematuria in patients with primary or metastatic bladder SCC.

  19. Lipomatosis simétrica benigna de la lengua en la enfermedad de Madelung Benign symmetric lipomatosis of the tongue in Madelung’s disease

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    A. López Ceres

    2006-04-01

    Full Text Available La enfermedad de Madelung, o lipomatosis simétrica benigna es una enfermedad rara caracterizada por acúmulos grasos no encapsulados localizados de forma simétrica alrededor de cuello y hombros. Esta enfermedad, afecta predominantemente a hombres en edades comprendidas entre los 30 y 60 años, con una relación hombre:mujer de 15:1. Existe una gran relación con el abuso del alcohol. Las personas no alcohólicas y las mujeres también pueden verse afectadas, aunque de forma más rara. Presentamos el caso de una mujer diagnosticada de Enfermedad de Madelung refiriendo engrosamiento progresivo de la lengua. Presentaba dificultad para tragar, disartria y disnea con el decúbito.Madelung´s disease, or benign symmetric lipomatosis, is an uncommon disease characterized by non-encapsulated accumulations of fat in a symmetric manner around the neck and shoulders. This uncommon disease predominantly affects men between the ages of 30 and 60 and it has a 15:1 ratio. There is a strong correlation with alcohol abuse. Nonalcoholics and women can also be affected although this is rare. We report the case of a woman diagnosed with Madelung’s disease, who described a gradual swelling of the tongue. She had difficulty swallowing, dysarthria and dyspnea while sleeping.

  20. Estudo histoquímico de proteínas fibrilares da matriz extracelular em neoplasias mamárias benignas e malignas na espécie canina

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    Ana Maria Cristina Rabello Pinto da Fonseca Martins

    2002-01-01

    Full Text Available A finalidade do presente trabalho foi estudar algumas das proteínas fibrilares da matriz extracelular de 54 neoplasias mamárias benignas e malignas na espécie canina, utilizando métodos histoquímicos: Picrosirius associado à polarização para fibras colágenas , método de Gordon - Sweats para fibras reticulares e método de Weigert com e sem oxidação para fibras elásticas. Evidenciou-se na matriz uma grande variabilidade na quantidade, distribuição e características dos componentes matriciais presentes nos diferentes tipos de neoplasias. Detectou-se, assim, colágeno I, III e elementos do sistema elástico, distribuídos diferentemente nas neoplasias benignas e malignas. O método Picrosirius simples e associado à polarização permitiu a visualização do colágeno sob a forma de fibras espessas distribuídas irregularmente no estroma dos carcinomas e de modo mais ordenado e regular nas neoplasias benignas e, fibras mais finas, em menor quantidade, irregularmente e aleatoriamente dispostas nos carcinomas e regularmente nas neoplasias benigna. Sob luz polarizada os feixes de fibras colágenas , apresentaram diferentes comprimentos, avermelhados ou amarelados e fortemente birrefringentes, sugerindo serem colágeno tipo I e, entremeando as fibras, algumas mais finas ,pálidas, esverdeadas e fracamente birrefringentes, presumivelmente colágeno tipo III. Em áreas condrometaplásicas, tanto nos carcinomas como nas neoplasias benignas notou-se que os feixes colágenos apresentavam-se com fibras finas, paralelas, limitando regiões estreitas onde os condrócitos se aninhavam, e, rodeando esta área, feixes de fibras espessas, anastomosadas, dispostas irregularmente nos carcinomas e ordenadamente e paralelas nas neoplasias benignas. Sob luz polarizada, essa população entre condrócitos era formada por fibras pálidas e amareladas, sugerindo padrão tipo II e na faixa circundante, feixes fortemente birrefringentes, sugerindo o padr

  1. Urinary Schistosomiasis in an Adolescent Refugee from Africa: An Uncommon Cause of Hematuria and an Emerging Infectious Disease in Europe.

    Science.gov (United States)

    Poddighe, Dimitri; Castelli, Lucia; Pulcrano, Giovanna; Grosini, Alessia; Balzaretti, Michela; Spadaro, Salvatore; Bruni, Paola

    2016-10-01

    We report a case of urinary schistosomiasis in an adolescent refugee from Gambia (arrived to Italy illegally), who was brought to the Emergency Department of our hospital. The patient complained of gross hematuria and, in the absence of clinical evidence of bacterial urinary infection, was admitted to the pediatric ward, considering his provenience and social setting. An appropriate collection and microscopic analysis of urine samples led to the detection of bilharzia. Much attention should be paid to this emerging disease in Europe by physicians in order to recognize and treat it timely, which could prevent future and higher costs for public health systems and could reduce the potential risk of environmental spreading. In fact, there are some areas in Italy where the parasite can find its intermediate host to complete its lifecycle.

  2. Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria

    NARCIS (Netherlands)

    van Kuilenburg, A. B. P.; Meijer, J.; Dobritzsch, D.; Lohkamp, B.; Ruitenbeek, W.; Roelofsen, J.; Abeling, N. G. G. M.; Duran, M.; Buzing, C.

    2008-01-01

    A patient with hematuria was shown to have thymine-uraciluria. The dihydropyrimidine dehydrogenase (DPD) activity in peripheral blood mononuclear cells was 0.16 nmol/mg/h; controls: 9.9 +/- 2.8 nmol/mg/h. Analysis of DPYD showed that the patient was compound heterozygous for the novel mutations 237C

  3. Incidencia en España de la asbestosis y otras enfermedades pulmonares benignas debidas al amianto durante el período 1962-2010

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    Montserrat García Gómez

    2012-01-01

    Full Text Available Fundamentos: En España carecemos de una descripción completa de las enfermedades profesionales causadas por el amianto. El objetivo del presente trabajo esconocer la incidencia durante el período 1962-2010 de las asbestosis y otras enfermedades pulmonares benignas por amianto reconocidas como profesionales y su distribución por sectores, ocupación, sexo y ámbito geográfico. Métodos: El número de casos se obtuvo de las Memorias del INP (años 1962 a 1975, de la Estadística del Ministerio de Trabajo y las Memorias del Servicio de Higiene y Seguridad en el Trabajo (1976 a 1981 y de los Anuarios de Estadísticas Laborales a partir de 1982. Se obtuvieron tasas de incidencia específicas por actividad económica y ocupación. Se estudió la tendencia temporal del número de enfermedades a estudio, así como su distribución geográfica por Comunidad Autónoma y provincia. Resultados: Desde 1963 hasta 2010 se reconocieron 815 asbestosis y 46 afecciones fibrosantes de pleura y pericardio. La incidencia media anual de asbestosis fue 0,20 por 100.000 personas asalariadas (0,31 en el año 1990 y 0,40 en 2010. De 1990 a 2001 el sector del fibrocemento acumuló 189 casos de asbestosis, el naval 173, la construcción 49 y la metalurgia 35. Por ocupación, los operadores de maquinas fijas presentaron 114 casos, los moldeadores, soldadores, chapistas y montadores de estructuras metálicas 88 casos y los pintores, fontaneros e instaladores de tuberías 59. Las Comunidades Autónomas con más casos fueron la Valenciana (106, Galicia (86, Andalucía (82, Cataluña (75, Madrid (58 y País Vasco (41. Conclusiones: Las tasas de incidencia y la tendencia de asbestosis profesionales en España pueden estar evidenciando el infrareconocimiento del origen profesional de estas enfermedades en nuestro país. Los sectores más afectados fueron el del fibrocemento y el naval y la incidencia más alta se dió en la Comunidad Valenciana.

  4. Manobras de reposicionamento no tratamento da vertigem paroxística posicional benigna Treatment of benign paroxysmal positional vertigo with repositioning manevers

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    Roberto A. Maia

    2001-09-01

    Full Text Available Introdução: Vertigem paroxística posicional benigna (VPPB é uma das mais freqüentes patologias do sistema vestibular. Caracteriza-se clinicamente pela presença de episódios recorrentes de tonturas rotatórias, tipicamente desencadeados por determinados movimentos cefálicos, realizados pelo paciente. A confirmação diagnóstica é obtida exclusivamente pela manobra de Dix-Hallpike. Nessa manobra, observa-se sistematicamente o desencadeamento de nistagmo. Forma de estudo: Prospectivo clínico não randomizado. Material e método: No total, sete pacientes com diagnóstico clínico de VPPB são submetidos a tratamento pela manobra de reposicionamento de Epley. Resultado: Desses sete pacientes avaliados, cinco apresentaram ótima recuperação; dois, com resultado bom; e um, com mau resultado; para este último caso, outras formas de tratamento são apresentadas. Conclusão: O exame otoneurológico, realizado em todos os pacientes, demonstrou ser de interessante valor prognóstico quanto ao resultado do tratamento proposto. A manobra de reposicionamento de Epley demonstrou ser um método de tratamento da VPPB simples, e eficaz na grande maioria dos pacientes aqui relatados.Introduction: Benign Paroxysmal Positional Vertigo (BPPV is among the most common vestibular disorders. It is characterized by recurrent episodes of vertigo induced by changes in head position. The condition is readly diagnosed by performing the Dix-Hallpike maneuver. Nystagmus is always present by this way. Study design: Prospective results clinical not randomized. Material and method: A total of seven patients diagnosed with BPPV received the repositioning maneuver of Epley. Five out of seven patients had excellent recovery, two patients had good results and one had a bad result. For this last one different treatments are discussed. Conclusion: We performed otoneurological examination in all patients; this test seems to be an intersting prognosis method for seeking the

  5. Minilaparoscopic-assisted transvaginal approach in benign liver lesions Abordaje transvaginal asistido por minilaparoscopia en lesiones benignas del hígado

    Directory of Open Access Journals (Sweden)

    R. Castro-Pérez

    2010-06-01

    benignas del hígado tratadas quirúrgicamente mediante el abordaje transvaginal asistido por minilaparoscopia. Pacientes y métodos: mujeres de 44 y 45 años de edad, respectivamente. La paciente 1 presentaba un pequeño tumor de 1,2 cm de Ø, en el lóbulo izquierdo del hígado. En su preoperatorio no se logró precisar su etiología y se decidió extirparlo quirúrgicamente. La paciente 2 presentaba un quiste simple del hígado muy sintomático de 8 cm de Ø situado en el subsegmento VI, se negó a realizarse el tratamiento esclerosante por vía percutánea, por lo que se recomendó el tratamiento quirúrgico. Se les ofreció a ambas realizar la intervención mediante cirugía laparoscópica o el abordaje transvaginal, aceptando este último. El neumoperitoneo se realizó con presión de 15 mmHg. Se colocaron 2 minipuertos en abdomen, uno en región umbilical de 5 mm Ø y el otro de 3 mm Ø en el sitio más próximo a la lesión. Con visión directa se colocó 1 trocar en la pared posterior del fondo del saco vaginal de 11 mm Ø para el paso de un endoscopio rígido. En la paciente 1 se utilizó este mismo orificio para, adyacente al trocar, introducir un disector largo. En la paciente 2 se introdujo un segundo trocar de 5 mm Ø para el paso de instrumentos de trabajo. Ambos especímenes fueron extraídos a través de la vagina en bolsas extractoras. Se registró el tiempo quirúrgico, necesidad de analgésicos y complicaciones postoperatorias. Resultados: los tiempos quirúrgicos fueron de 51 y 73 minutos, respectivamente. La paciente operada del quiste hepático requirió administración de analgésico postoperatorio. El alta hospitalaria fue dada antes de las 24 horas de la intervención. No se han presentado complicaciones postoperatorias relacionadas con el proceder después de un seguimiento mínimo de 6 meses. Conclusiones: con el empleo de instrumentos rígidos, fue posible realizar el tratamiento quirúrgico de dos lesiones benignas del hígado, de poca

  6. Tratamento conservador das estenoses benignas do esôfago através de dilatações. Análise de 500 casos

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    ANDREOLLO N.A.

    2001-01-01

    Full Text Available As estenoses benignas do esôfago (EBE são complicações muito freqüentes, resultado de várias etiologias, a saber: refluxo gastro-esofágico, ingestão de agentes corrosivos, pós-cirurgias do esôfago, pós-radioterapia no tórax, pós-escleroterapia endoscópica de varizes do esôfago, ingestão de medicamentos, uso prolongado de cateter nasogástrico, compressão extrínseca e membranas esofágicas congênitas. As dilatações esofágicas são recomendadas no tratamento dessa complicação, empregando dilatadores de vários tipos e diâmetros, facilitando ao doente a ingestão alimentar. OBJETIVOS: Avaliação dos resultados e vantagens do tratamento conservador das EBE através de dilatações esofágicas realizadas ambulatorialmente com auxílio da endoscopia digestiva flexível. MÉTODOS: No período de 1981 a 1999 foram tratados, conservadoramente e seguidos no Gastrocentro -- UNICAMP, 500 doentes com EBE, através de um Programa de Dilatações Esofágicas instituído para cada caso. A maioria era do sexo masculino (59,2% e a faixa etária mais acometida encontra-se entre 31 anos e 60 anos, compreendendo 52,8% dos pacientes em estudo. As estenoses mais prevalentes foram as estenoses pépticas (30,4%, cáusticas (23,6%, de anastomoses (23,2%, por megaesôfago (8,0% e por uso prolongado de cateter nasogástrico (6,4%, perfazendo um total de 91,6% das EBE. Quanto ao número de procedimentos, 94,2% dos casos foram submetidos a no máximo 25 dilatações do esôfago. Em 95,6% deles foram utilizados dilatadores com diâmetro entre 10,5 mm e 16,0 mm. A duração do tratamento foi até 24 meses em 76,2% dos casos. Perfurações esofágicas ocorreram em seis doentes (1,2%, sem mortalidade. RESULTADOS: Foram considerados bons em 76,2%, regulares em 18,2% e maus em 5,6% dos doentes. O sucesso do tratamento variou conforme a etiologia da estenose, ocorrendo bons resultados em 81,0% das estenoses pépticas, em 66,1% das estenoses cáusticas e em

  7. Valoración clínica, psicológica y de laboratorio a niños con hiperfenilalaninemia benigna al nacimiento

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    Enna Gutiérrez García

    2002-12-01

    Full Text Available Las hiperfenilalaninemias, alteraciones en el metabolismo de la fenilalanina, poseen heterogeneidad genética, clínica y bioquímica, con fenilalanina en plasma, mayor de 120 µmol/L (2 mg/dL. La benigna tiene valores entre 240 y 600 µmol/L (4 a 10 mg/dL con mayor actividad enzimática y no requiere tratamiento dietético. Se realizó una valoración clínica y de laboratorio a 32 niños con esta alteración al nacimiento entre 1989 y 1999, para conocer variaciones en las concentraciones séricas en el tiempo, presentación de algún síntoma o signo clínico de la enfermedad y el coeficiente de inteligencia de estos. Los 32 niños estudiados presentaron disminución de niveles del aminoácido, con respecto al nacimiento, entre 90 y 287 µmol/L (1, 5 mg/dL a 5, 52 mg/dL. La mayoría no mostró síntomas o signos clínicos de fenilcetonuria. El coeficiente de inteligencia promedio fue de 100,6 puntos. Se recomienda el estudio a todos los niños con esta alteración en Cuba y realizar estudios de mutaciones para demostrar la heterogeneidad alélica que explicara la expresividad variable en el fenotipo bioquímico y clínico en estos niños.Hyperphenylalaninemias, which are disorders in the metabolism of phenylalanine, show genetic, clinical and biochemical heterogeneity, with phenylalanine in plasma over 120 µmol/L (2 mg/dL. Benign hyperphenylalaninemia has values from 240 to 600 µmol/L (4 a 10 mg/dL with higher enzymatic activity and does not require diet therapy. A clinical and lab assessment of 32 children with this disorder at birth was made from 1989 to 1999 to find out the variations in time of serum concentrations, occurrence of some clinical symptom or sign of the disease and their intelligence quotient. The 32 studied children presented with reduction of aminoacid levels of 90 to 287 µmol/L (1, 5 mg/dL a 5, 52 mg/dL with respect to birth levels. The majority did not show clinical symptoms or signs of phenylketonuria. Average

  8. Diagnóstico topográfico de las hematurias en pacientes pediátricos mediante el porcentaje de hematíes dismórficos

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    Juan Bautista García Sánchez

    1997-04-01

    Full Text Available Se realizó un estudio para fijar un porcentaje de hematíes dismórficos que sirva de punto de corte óptimo para el diagnóstico topográfico de las hematurias en pacientes pediátricos. Se utilizaron datos clínicos y de laboratorio de 77 pacientes con hematuria glomerular y 15 con hematuria no glomerular. Mediante una metodología estadística se obtuvo 14 % como valor del punto, con lo que se asigna al grupo de las hematurias glomerulares todo paciente que presente una cifra de hematíes dismórficos igual o superior. El área bajo la curva ROC (Receiver Operating Characteristic asociada a este test fue 0,9597, lo que indica una elevada exactitud para la prueba, bastante cercana del valor ideal 1,0 que indica una discriminación perfecta.It was conducted a study to fix a percentage of dimorphic red cells acting as an optimal cutting point for the topographic diagnosis of hematurias in pediatric patients. Clinical and laboratory data of 77 patients with glomerular hematuria and of 15 with non glomerular hematuria were used. By using a statistical methodology it was obtained a value of 14 % for the point. Any patient having the same or a higher number of dimorphic red cells is included in the group of glomerular hematurias. The area beneath the ROC (Receiver Operating Characteristic curve associated to this test was of 0,9597, which indicates an elevated accuracy for the test, very close to the ideal value of 1,0 that shows a perfect discrimination.

  9. Transmisión patrimonial hereditaria y reproducción social en una parroquia rural de la Provincia de Maracaibo (Venezuela a fines del Antiguo Régimen

    Directory of Open Access Journals (Sweden)

    Luis Rincón Rubio

    2016-12-01

    Full Text Available Se realiza una aproximación al sistema familiar en la parroquia Inmaculada Concepción de La Cañada, Provincia de Maracaibo (Venezuela, a fines del siglo XVIII y principios del siglo XIX en su dimensión de transmisión intergeneracional de bienes. Para ello, se estudia la inclusión o exclusión concreta de los jóvenes adultos en relación a la herencia y el momento de la transmisión de la herencia para un conjunto de familias de la parroquia, a través del análisis de un conjunto de expedientes de inventarios y partición de bienes hereditarios. No se evidencian distorsiones significativas del modelo hereditario igualitario predominante en la parroquia en función de factores como el género o la primogenitura, lo cual confirma hallazgos previos que evidencian la predominancia en la parroquia de una ética de legitimidad entre generaciones basada en el principio de la parentela cognaticia, donde la vida social se representa como una red de relaciones entre parientes consanguíneos colaterales. La investigación realizada complementa los escasos estudios existentes y amplía el conocimiento sobre sistemas familiares y prácticas hereditarias en América Latina durante el Antiguo Régimen.

  10. Estudo exploratório da utilização de saw palmetto no tratamento da hiperplasia benigna da próstata por urologistas de Porto Alegre

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    Gabriela Ferreira

    Full Text Available O objetivo deste trabalho foi avaliar a utilização de fitoterápicos a base de saw palmetto na terapia sintomática da hiperplasia benigna da próstata (HBP por médicos urologistas da cidade de Porto Alegre. Consistiu em um estudo transversal, exploratório, por meio de entrevista semi-estruturada aplicada a urologistas de Porto Alegre. A amostra foi obtida utilizando catálogo do plano de saúde UNIMED- Porto Alegre. A randomização foi realizada através de sistemática aleatória, sendo sorteados trinta e cinco médicos, dos quais 21 foram selecionados para realização da pesquisa através de questionário. Todos os urologistas entrevistados avaliam e tratam pacientes com hiperplasia benigna da próstata. O saw palmetto não foi citado como terapia medicamentosa de 1ª ou 2ª escolhas no tratamento da HBP. O grupo farmacológico mais freqüentemente utilizado para o tratamento da HBP foi ∝-bloqueadores. Mais da metade dos médicos entrevistados relata ter conhecimento sobre a utilização do saw palmetto, principalmente através de artigos científicos. Os resultados indicam que o saw palmetto não é prescrito pelos urologistas em Porto Alegre, todavia a maior parte destes profissionais tem conhecimento sobre sua utilização.

  11. Percutaneous ultrasound-guided renal biopsy in children: The need for renal biopsy in pediatric patients with persistent asymptomatic microscopic hematuria

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    Mei-Ching Yu

    2014-12-01

    Full Text Available Background: Percutaneous renal biopsy (PRB is essential for the diagnosis, prognosis, and management of children with unknown kidney disease. In this study, the safety and efficacy of PRB is investigated, and also the common etiologies of childhood kidney disease, based on histological findings. In addition, we explored the role of PRBs in the diagnosis of children who presented with persistent asymptomatic hematuria. Methods: By chart review, from July 2005 to July 2009, a total of 99 PRBs were performed on 91 children (43 girls and 48 boys; mean age, 10.9 ± 4.4 years under ultrasound (US guidance, by a doctor, using an automated 18-gauge biopsy needle following the same protocol, at a medical center in northern Taiwan. Results: The accuracy of the histological diagnosis was excellent. The most common post-biopsy complications were perirenal hematoma (11.1% and asymptomatic gross hematuria (3.0%, respectively. Nevertheless, these complications resolved spontaneously, and none had major bleeding episodes. Histological results showed that lupus nephritis, minimal change disease, and IgA nephropathy (IgAN could be the current leading causes of childhood kidney diseases in Taiwan. Conclusions: Automated ultrasound (US-guided PRB is a safe and reliable method of assessing childhood renal disease. A recent study shows that the presence of persistent asymptomatic isolated microhematuria in adolescents is a predictive marker of future end-stage renal disease. Hence, the emphasis of renal biopsy on children with persistent asymptomatic hematuria is beneficial for the early diagnosis of IgAN or other glomerulonephritis (GN, which tends toward progressive kidney disease in adulthood without prompt therapeutic intervention.

  12. Inverted Nutcracker Syndrome: A Case of Persistent Hematuria and Pain in the Presence of a Left-Sided Inferior Vena Cava

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    Obi Ekwenna

    2011-01-01

    Full Text Available Nutcracker syndrome is described as the symptomatic compression of left renal vein between the aorta and the superior mesenteric artery, resulting in outflow congestion of the left kidney. We present the case of a 51-year-old male with a left-sided inferior vena cava, resulting in compression of the right renal vein by the superior mesenteric artery. Secondary to this anatomic anomaly, the patient experienced a many-year history of flank pain and intermittent gross hematuria. We have termed this unusual anatomic finding and its associated symptoms as the “inverted nutcracker syndrome”, and describe its successful management with nephrectomy and autotransplantation.

  13. Neoplasmas da bexiga associados à hematúria enzoótica bovina Urinary bladder neoplasms associated with bovine enzootic hematuria

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    Marione de Albuquerque Moreira Souto

    2006-10-01

    Full Text Available Relatam-se três casos de hematúria enzoótica bovina (HEB em animais provenientes do município de Jaguari, RS, Brasil. As pastagens de todas as propriedades de origem estavam altamente infestadas por samambaia (Pteridium aquilinum. Três bovinos, com idades entre 4 e 7 anos, apresentaram sinais clínicos que incluíam emagrecimento progressivo, hematúria intermitente e palidez das mucosas. As principais lesões foram observadas na bexiga e consistiam de três tipos de neoplasmas: hemangioma capilar, hemangiossarcoma e carcinoma de células escamosas. A epidemiologia, os sinais clínicos e as lesões macroscópicas e microscópicas observadas nos três bovinos são consistentes com o diagnóstico de HEB.Three cases of bovine enzootic hematuria (BHE are described in cattle from the municipality of Jaguari, Rio Grande do Sul, Brazil. The pastures of all affected farms were highly infested with bracken fern (Pteridium aquilinum. Three 4-7-year-old bovine had clinical signs of progressive weight loss, intermittent hematuria, and mucosal pallor. The main lesions were observed in the urinary bladder and consisted of three types of neoplasms: capillary hemangioma, hemangiosarcoma, and squamous cell carcinoma. The epidemiology, the clinical signs, and the gross and microscopic lesions observed in all three bovine were of BHE.

  14. Relationship between diet and benign prostatic hyperplasia Relación entre la dieta y el desarrollo de Hiperplasia Prostática Benigna: ¿Qué nos dice la evidencia científica actual?

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    Jon Kepa Balparda Arias

    2010-02-01

    Full Text Available

    Benign prostatic hyperplasia is very common in the general population, both from the histological and the clinical points of view. The role of different factors in its development has been defined by means of epidemiological studies. One such factor is the composition of the diet, as the regular consumption of certain foods may either protect against benign prostatic hyperplasia or increase the risk of its development. Among foods which may play a protective role are lycopene, phytoestrogens and vegetables. On the other hand, the risk of developing the disease may be increased by a diet rich in fat and calories. In this article the main clinical trials concerning this relationship are reviewed, as a way of informing physicians on the dietetic patterns that may influence the frequency or the symptoms of this disease.

    La hiperplasia prostática benigna es muy común en la población general, tanto desde el punto de vista histológico como del clínico. El papel en ella de diversos factores se ha definido por medio de estudios epidemiológicos. Entre ellos está el consumo regular de algunos alimentos que podría actuar como un factor protector o de riesgo para el posterior desarrollo de la enfermedad. Entre los compuestos demostrados como benéficos para la salud prostática están los licopenos, los fitoestrógenos y las verduras. Por otro lado, entre los que podrían aumentar el riesgo de sufrir la hiperplasia prostática benigna se incluyen las dietas hipercal

  15. Prostate Artery Embolization (PAE) in the Management of Refractory Hematuria of Prostatic Origin Secondary to Iatrogenic Urological Trauma: A Safe and Effective Technique.

    Science.gov (United States)

    Kably, Isaam; Pereira, Keith; Chong, William; Bhatia, Shivank

    2016-02-01

    Incidence of refractory hematuria of prostatic origin (RHPO) is extremely rare, with an iatrogenic etiology even rarer. When conservative methods fail to control bleeding, more invasive surgical methods are needed. In this article we describe our experience with prostatic artery embolization (PAE) as a minimally invasive alternative treatment option in patients with RHPO secondary to iatrogenic urologic trauma. Three patients presented with RHPO. The etiologies were transurethral resection of prostate surgery, Foley catheter removal with a supratherapeutic international normalized ratio and self-traumatic Foley catheter removal respectively. Stepwise management with conservative and medical methods failed to control bleeding. Under local anesthesia and moderate sedation, bilateral PAE was performed via a right common femoral artery access and using cone beam computed tomography. An embolic mixture containing 300-500 um Embosphere® Microspheres (Biosphere Medical, Rockland, MA) was injected under fluoroscopic guidance until stasis was achieved. PAE using the described technique was a technical and clinical success in all three patients. Hematuria resolved within a period of 24 hours. There were no intra- or periprocedural complications. PAE offers a reasonable option in treatment of RHPO, regardless of the cause and may be attempted prior to surgical techniques or sometimes in conjunction. Being minimally invasive and performed under local anesthesia, PAE is especially useful when excessive bleeding prevents adequate visualization of a bleeding source during cystoscopy and in the elderly age group with several comorbidities. An added advantage is the prostatic parenchymal ischemia leading to significant prostate volume reduction and alleviation of the obstructive symptoms. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Role of Helicobacter pylori in stomach cancer after partial gastrectomy for benign ulcer disease Papel del Helicobacter pylori en el cáncer gástrico tras gastrectomía parcial por úlcera benigna

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    A. Seoane

    2005-11-01

    Full Text Available Objective: to determine the prevalence of Helicobacter pylori infection in patients having undergone gastrectomy for non-neoplastic disease who later developed gastric stump cancer. Material and methods: retrospective study of all patients with partial gastrectomy for non-malignant peptic disease who were submitted to an endoscopic exploration between 1995 and 2001. A comparison was made of major clinical and histological characteristics, and the presence of Helicobacter pylori among patients with and without gastric cancer in the stomach remnant. Results: a total of 73 patients were studied in this period. Fifteen patients (20.5% had remnant-stump gastric cancer. All but one were adenocarcinomas (71% intestinal and 29% diffuse, respectively. The average time between diagnosis of gastric cancer and previous gastrectomy was 32 (14-48 years. There was a higher detection rate of Helicobacter pylori in patients with cancer in the gastric remnant (100 vs. 81.5%, respectively, p Objetivo: determinar la prevalencia de la infección por Helicobacter pylori en pacientes gastrectomizados por enfermedad no neoplásica, y que han desarrollado posteriormente cáncer gástrico. Material y métodos: estudio retrospectivo con reclutamiento de todos los pacientes con gastrectomía parcial por enfermedad péptica benigna que han sido sometidos a una exploración endoscópica entre 1995-2001. Se ha realizado una comparación de las principales características clínicas e histológicas y de la presencia de Helicobacter pylori en los pacientes con y sin cáncer del remanente gástrico. Resultados: se han estudiado un total de 73 pacientes en este periodo. Se han encontrado 15 pacientes (20,5% con cáncer en el remanente gástrico, 14 adenocarcinomas (71% tipo intestinal y 29% tipo difuso y un linfoma. El tiempo transcurrido entre el diagnóstico de cáncer gástrico y la gastrectomía previa ha sido de 32 (14-48 años. Se ha detectado un alto porcentaje de infecci

  17. Estenoses benignas de esôfago: abordagem endoscópica com velas de Savary-Gilliard Benign strictures of the esophagus: endoscopic approach with Savary-Gilliard bougies

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    Paula Novais

    2008-12-01

    Full Text Available RACIONAL: As estenoses benignas de esôfago são complicações decorrentes de diversas causas. Possuem tratamentos similares, na maioria dos casos necessitando de dilatação endoscópica, no entanto a resposta terapêutica, tempo ideal de tratamento, assim como intervalo entre as sessões podem ser variáveis. OBJETIVO: Analisar, do ponto de vista endoscópico, as estenoses benignas de esôfago em 14 anos de experiência no Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro, RJ, avaliando etiologia, a extensão da estenose, o número de dilatações necessário para atingir resposta terapêutica satisfatória, assim como a relação entre a extensão da estenose e a resposta terapêutica. MÉTODO: Foram analisadas 2.568 dilatações endoscópicas com uso de velas de Savary-Gilliard em 236 pacientes, durante um período de 14 anos e 10 meses, até junho de 2007. RESULTADOS: A estenose péptica foi a causa mais freqüentemente encontrada, seguida pela estenose cáustica. As estenoses longas e cáusticas necessitaram de maior número de sessões para ausência de disfagia. Estenoses pépticas e curtas responderam melhor a número menor de sessões de dilatação. CONCLUSÃO: A estenose péptica foi a causa mais comum e respondeu bem à terapia endoscópica, em concordância com a literatura. As estenoses cáusticas foram as mais refratárias, principalmente as longas. Quanto maior foi a extensão da estenose, também maior foi o número de sessões necessárias. Estenoses curtas apresentaram boa evolução na maioria dos casos. O número de dilatações necessárias dependeu diretamente da causa e da extensão da estenose.BACKGROUND: Benign esophageal strictures are complications that result from different causes. They are usually similarly approached, most of the cases needing endoscopic dilation. However the response to therapy, optimal timing for treatment and interval between sessions can vary. AIM: The

  18. Genes relacionados con microftalmia y anoftalmia hereditarias.

    Science.gov (United States)

    Matías-Pérez, Diana; García-Montalvo, Iván Antonio; Zenteno, Juan Carlos

    2017-01-01

    Congenital eye malformations are the second most common cause of childhood blindness and are originated by disruption of the normal process of eye development during embryonic stage. Their etiology is variable, although monogenic causes are of great importance as they have a high risk of familial recurrence. Included among the most severe congenital eye abnormalities are microphthalmia, defined by an abnormally small eye, and anophthalmia, characterized by congenital absence of ocular structures. The currrent knowledge of the genes involved in human microphthalmia and anophthalmia in humans is revised in this work. Copyright: © 2017 SecretarÍa de Salud.

  19. Ação do radium sôbre o vírus da Coriomeningite linfocitária benigna Radium effect upon the lymphocytic choriomeningitis virus

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    J. Guilherme Lacorte

    1968-01-01

    Full Text Available O presente trabalho faz parte de uma seqüência iniciada em 1953 com a verificação do efeito dos raios X sôbre o vírus da gripe em que observamos que os mesmos, em doses fracas, tem aumentado o seu poder patogênico para camundongos. Posteriormente, verificamos a ação do radium sôbre o vírus da gripe e da poliomielite. Neste último caso, o vírus irradiado mostrou-se ativo durante maior número de dias. Nas pesquisas aqui referidas, submetemos o vírus da coriomeningite linfocitária benigna a ação do radium, usando quatro agulhas de 1 mg desse elemento em dispositivo que idealizamos para êste fim. Depois de irradiada, foi a suspensão de vírus diluida a 10*-1, 10*-2 e 10*-3 para as inoculações em camundongos, juntamente com as diluições testemunhas. Observamos que o vírus resistiu pelo menos 264 dias, à temperatura de 4ºC. Quanto às alterações do poder patogênico provocadas pelo radium verificamos que o mesmo não se altera após 24 horas de irradiação. Diminue após 8 dias para aumentar, de modo seguro, após 20 e 33 dias. Iguala-se ao testemunha depois de 78 dias.In the present paper the authors refered the experiments made with the lymphocytic chriomeningitis virus. We strain, after exposition to 4 tubes of 1 mg of radium. The virus suspension was put into the Carrel flask in a layer of 0,1 cm. The titrations of the irradiated virus suspension were made after 24 hours, 8, 20, 33, 78, 85, 120, 264, 292, 387 and 535 days. the virus was still active after 264 days, not after 292 days. The virus irradiated during 24 hours presented the same pathogenicity form mice than the control but after 8 days it was lesser and after 20 and 33 days it was enchanced (Graphic 10. After 78 days the pathogenic power was the same for the irradiated virus and the control.

  20. Influencia del tratamiento quirúrgico de la próstata sobre la función renal en pacientes con insuficiencia renal crónica secundaria a hiperplasia prostática benigna

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    Roxana Aguirre Castañeda

    2002-07-01

    Full Text Available Objetivo: Evaluar la influencia del tratamiento quirúrgico sobre la función renal en pacientes con Insuficiencia Renal Crónica (IRC causada por Hiperplasia Prostática Benigna (HPB. Material y métodos: Es un estudio descriptivo, retrospectivo y analítico de series de casos; cuya variable resultado principal fue el delta de creatinina (creatinina post cirugía - creatinina pre-cirugía, los deltas de creatinina negativos se categorizaron como mejoría de la función renal y los deltas de creatinina positivos como deterioro de la función renal. Resultados: De 40 casos, 24 cumplían con los criterios de inclusión. La edad promedio fue de 67.2 ± 6.8 años. El síntoma más frecuente fue el chorro urinario delgado presentándose en 20 (83.3% pacientes. Trece(54.17% pacientes tuvieron una próstata mediana, quienes con los pacientes de próstata grande refirieron con mayor frecuencia el síntoma de polaquiuria (p=0.03. El tratamiento quirúrgico de pacientes con IRC por HPB produjo una mejoría de la función renal en el 83% de los casos. Solo 4(16.67% pacientes tuvieron delta de creatinina positivo con disminución de la función renal post-cirugía. Se encontró una correlación directa entre la edad y el delta de creatinina (r=0.55 (p=0.004 traduciendo una asociación del deterioro de la función renal post-cirugía con la edad. Conclusiones: El tratamiento quirúrgico de pacientes con IRC por HPB produjo una mejoría de la función renal en la mayoría de los pacientes evaluados en este estudio. No se identificó factores de riesgo relacionados con un deterioro o mejoría de la función renal post-cirugía. (Rev Med Hered 2002; 13: 99-104.

  1. A intervenção fonoaudiológica no pós-operatório da hipertrofia benigna do músculo masseter The miofunctional oral intervention in the surgery treatment for the masseter muscle hipertrophy

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    Laura Davison Mangilli

    2006-04-01

    Full Text Available OBJETIVO: descrever a abordagem fonoaudiológica no pós-operatório de pacientes que realizaram correção cirúrgica da hipertrofia do músculo masseter. METODOLOGIA: foram coletados dados referentes à avaliação e ao tratamento fonoaudiológico de 4 prontuários de sujeitos de ambos os gêneros, com faixa etária entre 16 e 24 anos, com hipertrofia benigna do músculo masseter, tratados cirurgicamente. RESULTADOS: as principais queixas pós-cirúrgicas estiveram relacionadas à limitação da abertura da boca, à dor na região da cirurgia, à rigidez muscular e a estalo em região da ATM. A terapia fonoaudiológica baseou-se em orientação quanto à retirada de hábitos deletérios; termoterapia na região do músculo masseter; manipulação da musculatura envolvida extra e intrabucais; alongamento da musculatura facial e cervical; alavanca de abertura forçada de boca e exercícios de órgãos fonoarticulatórios. CONCLUSÕES: a terapia fonoaudiológica apresenta-se como uma possibilidade de complementação ao tratamento cirúrgico, na adequação da amplitude dos movimentos mandibulares, assim como na eliminação dos sintomas presentes no pós-cirúrgico e na conscientização dos hábitos deletérios, que são apontados pela literatura como possíveis fatores desencadeantes.AIM: the aim of this study was to describe miofunctional oral intervention in patients with Masseter muscle hipertrophy treated by surgery. METHODS: the sample consisted of 4 patients, male and female, with ages between 16 and 24 years, with Masseter muscle hipertrophy treated by surgery. RESULTS: the main complains on the postoperative were related to trismus, muscle rigidity, and clicking in the temporomandibular joint. The myofunctional oral therapy was based on orientation in the abnormal habits (bruxism, clenching elimination, hyperthermia induced in the masseter muscle, oral muscles massage, facial and cervical muscles stretching, miofunctional exercises and

  2. Aspectos clínicos e funcionais do equilíbrio corporal em idosos com vertigem posicional paroxística benigna Clinical and functional aspects of body balance in elderly subjects with benign paroxysmal positional vertigo

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    Daniela Patricia Vaz

    2013-04-01

    Full Text Available Vertigem Posicional Paroxística Benigna (VPPB pode alterar o equilíbrio corporal em pacientes idosos. OBJETIVO: Observar os efeitos da manobra de Epley em idosos com VPPB, avaliando os aspectos clínicos e funcionais do equilíbrio corporal. Forma de estudo: clínico e prospectivo. MÉTODO: Após o diagnóstico da doença (teste de DixHallpike, os testes Time Up and Go (TUGT, Clinical test of Sensory Interaction and Balance (CTSIB e o teste de membros inferiores (MMI foram realizados antes e após a manobra de reposicionamento de Epley modificada. RESULTADOS: O gênero feminino foi o mais prevalente e a média etária foi de 70,10 anos (DP = 7,00. Todos os pacientes apresentaram ductolitíase de canal posterior. Os seguintes sintomas melhoraram após a manobra: a instabilidade postural (p = 0,006, náusea e vômito (p = 0,021 e zumbido (p = 0,003. Em relação ao TUGT e o escore do teste de MMII, observou-se diminuição significante do tempo pós-manobra de Epley (p Benign paroxysmal positional vertigo (BPPV may compromise the balance of elderly subjects. OBJECTIVE: To observe the effects of the Epley maneuver in elderly subjects with BPPV and assess clinical and functional aspects of body balance. METHOD: This is a prospective clinical study. Patients diagnosed with BPPV (Dix-Hallpike test were submitted to the Timed Up & Go (TUG test, the Clinical Test of Sensory Interaction and Balance (CTSIB, and lower limb testing before and after they were repositioned using the modified Epley maneuver. RESULTS: Most subjects were females, and the group's mean age was 70.10 years (SD = 7.00. All patients had canalithiasis of the posterior canal. The following symptoms improved after the maneuver: postural instability (p = 0.006, nausea and vomiting (p = 0.021, and tinnitus (p = 0.003. Subjects improved their times significantly in the TUG and lower limb tests after the Epley maneuver (p < 0.001. Patients performed better on the CTSIB after the Epley

  3. Correlación entre niveles de ferritina sérica y unidades de transfusión recibidas por pacientes con anemias hereditarias hemolíticas en el estado de Zulia, Venezuela

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    Ana Z. Ruiz E

    2014-04-01

    Full Text Available La hipertransfusión es un tratamiento comúnmente utilizadas en pacientes con anemias hemolíticas hereditarias (AHH, como la anemia de células falciformes (ACS y/o beta talasemia (βT. Las concentraciones de ferritina sérica son constantemente monitoreadas en estos pacientes para detectar rápidamente la presencia de sobrecarga de hierro. El objetivo del estudio fue determinar si hubo correlación entre los valores de ferritina sérica y el número de unidades de transfusión de concentrado eritrocitario suministradas a los pacientes con ACS y βT mayor o intermedia durante un año. Se realizó un estudio prospectivo de 39 pacientes,22 fueron diagnosticados de ACS y 17 con βT, en edades comprendidas entre los 4 y 82 años. Estos pacientes fueron tratados en el "Instituto Hematológico de Occidente -Banco de Sangre del Estado Zulia y el Hospital Universitario de Maracaibo Venezuela”. Ferritina sérica se determinó por el método de quimioluminiscencia. La media y la desviación estándar de ferritina fueron 915,4 ± 567,8 ng/ml para los pacientes con ACS y 3.338 ± 874,6 para βT (p: 0.0001 Las unidades de concentrado eritrocitario transfundidas fueron 6 ± 2,3 y 21 ± 7,5 respectivamente (p: 0.0001. Hubo correlación estadísticamente significativa entre el número de unidades de concentrado eritrocitario transfundidas y los valores de ferritina sérica en el grupo de ACS (r=0,832, p=0,0001 y el grupo βT (r=0,491, p=0,045. Los resultados del presente estudio sugieren una estrecha correlación entre las concentraciones de ferritina sérica y las unidades de concentrado eritrocitario transfundidas en los pacientes con ACS pero no en los pacientes con βT. Correlations between ferritin levels and transfusion units received by pacients with hereditary hemolytic anemia in the state of Zulia, Venezuela Abstract Blood transfusions are a commonly used treatment or patients with hereditary hemolytic anemias, such as: sickle cell anemia (SCA and

  4. Usefulness of the UBCTM (urinary bladder cancer) test compared to urinary cytology for transitional cell carcinoma of the bladder in patients with hematuria

    International Nuclear Information System (INIS)

    Gil, Myung Cheol; Kang, Do Young; Seong, Youl Koon

    2001-01-01

    Urinary cytology and cystoscopic exam are effective methods for diagnosis of transitional cell carcinoma (TCC). But the former shows drawbacks such as the need for a well-trained examiner, and wide imprecision related to the variability of microscopic exam; the latter is a invasive method. UBC TM test detects the epitope on specific cytokeratin fragments released from epithelium of bladder cancer by immunoradiometric assay. We compared UBC TM test with urinary cytology for diagnosis of TCC to evaluate the utility of UBC TM test. Eighty-four patients with hematuria were included in our study, UBC TM tests (IDL Biotech, Sweden) were assayed in mid-stream urine according to the ordinary assay protocol. Nineteen patients were confirmed as TCC by cystoscopic examination and underwent transurethral resection (Group A). Other patients had various benign urinary tract conditions (Group B). Samples were considered positive as the UBC TM concentration was greater than 12 μg/L. UBC TM levels were significantly different between group A (95.9 ±166.4 μg/L) and group B (19.2 ± 85.6 μg/L)(p TM test and 100% (65/65) in cytology. UBC TM test was significantly more sensitive in stage Ta, T 1 tumors (84.6 vs 38.5%, p TM test showed a tendency to be more sensitive as the grade was higher (83.3% in Grade 1, 90% in Grade II and 100% in Grade III). UBC TM test could be a useful method in distinguishing TCC from other benign genitourinary diseases. Moreover, UBC TM test could be an especially valuable marker for diagnosis of TCC in patients with early TCC of low grade TCC compared to urinary cytology. Therefore, mbined use of UBC TM test in association with cytology is helpful to overcome the limited sensitivity of cytology

  5. Efeito da manobra de Epley na qualidade de vida dos pacientes com vertigem posicional paroxística benigna Effect of Epley's maneuver on the quality of life of paroxismal positional benign vertigo patients

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    Alcione Botelho Pereira

    2010-12-01

    Full Text Available A vertigem produz impactos significativos na qualidade de vida (QV. É necessário mensurar os efeitos das terapêuticas antivertiginosas na QV. OBJETIVO: Investigar o efeito da manobra de reposicionamento na qualidade de vida de pacientes com vertigem posicional paroxística benigna (VPPB. MATERIAL E MÉTODOS: Estudo retrospectivo, através da revisão dos prontuários de 21 pacientes com VPPB atendidos no serviço de Reabilitação Vestibular (RV de uma clínica escola de Belo Horizonte atendidos em 2007-2008. Foram analisados os escores físicos, funcionais e emocionais, pré e pós-terapia de RV com realização de manobras de reposicionamento de Epley, por meio do questionário Dizziness Handicap Inventory (DHI, específico para avaliação da interferência da tontura na QV. RESULTADOS: O intervalo mediano entre as avaliações foi de 21 dias. O número médio de manobras foi 2,3±1,1. A aplicação do DHI mostrou um significante impacto da VPPB na QV dos pacientes em todas as dimensões da vida diária, com os seguintes escores médios pré e pós-terapia: físico (17,5/3,7, funcional (17,3/3,9, emocional (13,2/3,2 e total (48,1/10,9, respectivamente (pQuality of life (QoL is significantly impaired by vertigo. The effect of specific treatments on QoL deserves investigation. AIM: To assess the effect of repositioning maneuvers on the QoL of benign paroxysmal positioning vertigo (BPPV patients. MATERIALS AND METHODS: A retrospective study design consiting of reviews of charts of BPPV patients in a vestibular rehabilitation unit at a teaching institution in Belo Horizonte, MG, Brazil, from 2007 to 2008. Pre- and post-therapy (Epley's repositioning maneuver scores on the physical, functional and emotional dimensions of the Dizziness Handicap Inventory (DHI were analyzed. RESULTS: Twenty-one patients were included, eighteen (86% were females; the average age was 53.2 years. Ten patients presented bilateral BPPV; in eleven it was unilateral

  6. Variáveis reprodutivas e risco para doenças benignas de mama: estudo caso-controle Reproductive variables and risk of benign breast diseases: a case-control study

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    Ellen E. Hardy

    1990-10-01

    Full Text Available Foram estudadas 257 mulheres com diagnóstico de doença benigna de mama (DBM, atestado por anatomopatológico ou citologia, e um controle para cada uma delas. Foram apresentados resultados das possíveis relações entre variáveis reprodutivas e o risco para DBM. Os casos e controles foram comparados levando em conta a idade na menarca e na menopausa, o número de gravidezes, de meses em que amamentaram e de ciclos menstruais ovulatórios, e os antecedentes familiares de câncer de mama. Mostraram influência significativa, em relação às DBM, a nuliparidade, aumentando o risco enquanto a idade de 30 ou mais anos no primeiro parto o reduziu; o número de ciclos ovulatórios, que foi significativamente maior para os casos, e a média de meses de uso de pílula, menor entre as mulheres com DBM. O uso de contraceptivos orais apresentou um efeito protetor apenas quando a duração total do uso foi maior que dois anos. Os resultados não se revelaram novos ou diferentes se comparados com outros estudos, mas confirmam a relativa concordância entre os fatores de risco para DBM e para câncer de mama, ainda que as relações entre esses fatores e as DBM não sejam tão claras como o são para o câncer, e existam também algumas discrepâncias.The purpose of the study was the identification of risk factors for benign breast diseases (BBD; 257 women with BBD diagnosed through pathological anatomy or citology and a matched control for each were studied. Subjects were selected at The State University of Campinas Hospital and at a private clinic. To enter the study cases had to have a first diagnosis of BBD between October 1979 and August 1984. The following BBD were considered: dysplasia, fibroadenoma, cystic disease, papilloma and ductal ectasia. Reproductive variables were studied as risk factors, including menstrual ovulatory cycles. The date on which the BBD was diagnosed was defined as the index date. For controls, data were considered up to when

  7. Manobras para o tratamento da vertigem posicional paroxística benigna: revisão sistemática da literatura Maneuvers for the treatment of benign positional paroxysmal vertigo: a systematic review

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    Lázaro Juliano Teixeira

    2006-02-01

    Full Text Available A Vertigem Posicional Paroxística Benigna (VPPB é uma das mais freqüentes patologias do sistema vestibular e é caracterizada por episódios de vertigens recorrentes desencadeados por movimentos da cabeça ou mudanças posturais. Há várias opções para o seu tratamento, porém as efetividades terapêuticas das mesmas permanecem controversas. OBJETIVO: Avaliar a efetividade terapêutica das manobras específicas disponíveis para o tratamento da VPPB. METODOLOGIA: Realizou-se uma busca eletrônica nas principais bases de dados, selecionando-se estudos clínicos randomizados envolvendo adultos com diagnóstico de VPPB confirmado com o teste de Dix-Hallpike e tratamento com manobras específicas (Epley ou Semont, por exemplo. Considerou-se como desfecho clínico a negativação do teste de Dix-Hallpike e a melhora das queixas subjetivas. Agruparam-se em metanálise os estudos com Escala de Jadad igual ou superior a três. RESULTADOS: Cinco estudos clínicos preencheram os critérios de inclusão, ou seja, ensaios randomizados de fase I comparando a manobra de Epley com placebos e controles. A metanálise mostra evidência dos efeitos benéficos da manobra de Epley para o tratamento do canal semicircular posterior (magnitude do efeito de 0,11 [IC 95% 0.05, 0.26] de melhora objetiva (Dix-Halpike após uma semana, 0.24 [IC 95% 0.13, 0.45] após um mês e 0.16 [IC 95% 0.08, 0.33] de melhora referida pelos pacientes após a primeira semana. CONCLUSÃO: Evidencia-se boa eficácia clínica da manobra de Epley para o tratamento da VPPB do canal semicircular posterior. Contrariamente, trabalhos com a manobra de Semont e as propostas de manejo dos demais canais semicirculares não obtiveram qualidade metodológica satisfatória, não sendo possível demonstrar a efetividade dos mesmos.Benign Paroxysmal Positional Vertigo (BPPV is one of the most frequent diseases of the vestibular system and it is characterized by episodes of recurrent vertigo

  8. Critérios histopatológicos para diagnóstico de melanoma maligno cutâneo: análise comparativa de sua freqüência em lesões benignas e melanomas de pequena espessura (< 2 mm Histopathological criteria for cutaneous malignant melanoma: comparative analysis between benign and thin malignant lesions (< 2 mm

    Directory of Open Access Journals (Sweden)

    Luiz Alberto Veronese

    2007-10-01

    Full Text Available INTRODUÇÃO: A histopatologia convencional continua sendo o padrão-ouro no diagnóstico dos melanomas cutâneos, apesar do progresso da imuno-histoquímica e da biologia molecular. Os critérios microscópicos existentes para esse diagnóstico são numerosos, porém nenhum deles é específico para se afirmar que uma determinada lesão é maligna quando ele está presente, ou é benigna na sua ausência. Alguns critérios têm uma relevância maior para o diagnóstico em relação a outros. OBJETIVO: Este estudo propõe uma análise daqueles critérios considerados mais importantes, comparando sua presença em lesões melanocíticas benignas e melanomas. MATERIAL E MÉTODOS: Foram estudadas 33 lesões melanocíticas benignas (nevo de Spitz: 13; nevo de Reed: 6; nevo displásico: 6; nevo congênito: 3; nevo adquirido: 3; nevo combinado: 1; nevo recorrente: 1, bem como 101 casos de melanomas extensivo/superficiais: 25 intra-epidérmicos e 76 invasivos de pequena espessura (INTRODUCTION: Conventional histopathology has been considered as the gold standard in the diagnosis of cutaneous malignant melanoma, despite the progress of molecular biology and immunohistochemistry. There are many microscopic criteria for diagnosis of melanoma, however there is not a single one that can be useful to define malignancy. AIM: Our purpose is to analyse the criteria considered more important to the diagnosis of melanoma, comparing their presence in benign melanocytic lesions and melanomas. MATERIAL AND METHODS: We studied 33 benign melanocytic lesions (Spitz nevi, 13; Reed nevi, 6; dysplastic nevi, 6; congenital nevi, 3; acquired nevi, 3; combined nevus, 1; recurrent nevus, 1 and 101 extensive/superficial melanomas (25 in situ and 76 invasive up to 2 mm thickness. RESULTS: Some criteria showed high frequency in benign lesions, showing low-specificity, while others had low-positivity in the benign and high-frequency in malignant lesions, consequently high

  9. Sequential motor task (Luria's Fist-Edge-Palm Test in children with benign focal epilepsy of childhood with centrotemporal spikes Tarefa motora sequencial (Teste de Lúria punho-lado-palma em crianças com epilepsia focal benigna da infância com descarga centrotemporal

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    Carmen Silvia Molleis Galego Miziara

    2013-06-01

    Full Text Available This study evaluated the sequential motor manual actions in children with benign focal epilepsy of childhood with centrotemporal spikes (BECTS and compares the results with matched control group, through the application of Luria's fist-edge-palm test. The children with BECTS underwent interictal single photon emission computed tomography (SPECT and School Performance Test (SPT. Significant difference occurred between the study and control groups for manual motor action through three equal and three different movements. Children with lower school performance had higher error rate in the imitation of hand gestures. Another factor significantly associated with the failure was the abnormality in SPECT. Children with BECTS showed abnormalities in the test that evaluated manual motor programming/planning. This study may suggest that the functional changes related to epileptiform activity in rolandic region interfere with the executive function in children with BECTS.Esse estudo avaliou ações motoras manuais sequenciais em crianças com epilepsia focal benigna da infância com descarga centrotemporal (EBICT e comparou os resultados com o grupo controle pareado, através do teste de Lúria (punho-lado-palma. As crianças com EBICT realizaram single photon emission computed tomography (SPECT interictal e Teste de Desempenho Escolar (TDE. Foram encontradas diferenças significativas entre os dois grupos nas atividades motoras de três movimentos iguais e três movimentos diferentes. As crianças com piores resultados no TDE e com SPECT alterado apresentaram mais erros no teste de imitação manual. Crianças com epilepsia fracassaram nos testes de avaliação motora que envolvem programação/planejamento. Esse estudo sugere que mudanças funcionais relacionadas à atividade epileptiforme na região rolândica interfere com as funções executivas de crianças com EBICT.

  10. Epilepsia occipital benigna da infância de início precoce (tipo Panayiotopoulos: aspectos clínicos e eletrencefalográficos evolutivos em 14 crianças Early-onset benign childhood occipital epilepsy (Panayiotopoulos type: clinical and electroencephalographic features in 14 children

    Directory of Open Access Journals (Sweden)

    Lineu Correa Fonseca

    2005-06-01

    Full Text Available Foram estudadas as características evolutivas clínico-eletrencefalográficas de 14 crianças com epilepsia occipital benigna da infância de início precoce (tipo Panayiotopoulos. O tempo médio de segmento foi 50,5 meses. A idade média na primeira crise foi 3,7 anos. O número total de crises foi até 3 crises em 11 casos, numerosas em 3; o período médio entre a primeira e a última crise foi 14,5 meses. Em 4 casos as crises tiveram duração prolongada, constituindo estado de mal parcial. Atividade epileptiforme (AE occipital foi observada em todos os casos no primeiro EEG e, foi também, extra-occipital, em 3 casos. Houve bloqueio da AE occipital, pela abertura dos olhos, em 4 casos; em 3 casos foram observadas, também, pontas evocadas. O EEG normalizou-se em 9 casos, em um período médio de 29 meses.We studied clinical and electroencephalographic features of 14 children, age range of 2 -8 years, with no neurological or neuroradiological evidence of brain damage and with occipital epileptiform activity in the EEG. Seizures were numerous in 3 cases. Age at onset was between 1-7 years. In 4 cases the seizures last for more than 20 min. Spikes were observed in 6 cases and spike and slow-wave complex in 8. Discharges blocking by eyes opening were confirmed in 4 cases. Somatosensory evoked spikes by foot stimulation were observed in 2 cases. Autonomic and versive seizures are the main clinical manifestations of Panayiotopoulos syndrome. Discharges blocking by eyes opening are a less frequent feature.

  11. Comparison of histological and molecular diagnosis of Helicobacter pylori in benign lesions and gastric adenocarcinoma Comparação dos diagnósticos histológico e molecular do Helicobacter pylori em lesões benignas e adenocarcinomas gástricos

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    Ana Cristina Gobbo César

    2005-03-01

    comparar os resultados do diagnóstico histológico usado de rotina na detecção do H. pylori com o diagnóstico molecular. Foram utilizadas amostras de 80 lesões gástricas (gastrite crônica, gastrite atrófica, úlcera gástrica e metaplasia intestinal, 18 amostras de adenocarcinoma gástrico e 10 amostras de mucosa gástrica normal H. pylori negativas (controle. Todas as amostras foram avaliadas histologicamente (coloração com hematoxilina-eosina e Giemsa e pela PCR com a amplificação dos genes antígeno espécie-específico (H3H4 e urease A (H5H6 do H. pylori e pelo gene humano CYP1A1, como controle da qualidade do DNA. Nas amostras de lesão benigna e adenocarcinoma gástrico, a infecção foi detectada em 43% (42/98 e 71% (70/98, respectivamente, para os diagnósticos histológico e molecular (p = 0,0001. O teste de PCR detectou o H. pylori em 27,5% (22/80 das lesões gástricas benignas e em 50% (9/18 dos adenocarcinomas gástricos, com diagnóstico histológico negativo para essa bactéria. Cerca de 2,5% das amostras, exclusivamente de lesões benignas, com diagnóstico histológico positivo apresentaram resultado molecular negativo, para ambos os primers. Diferenças estatisticamente significantes foram encontradas entre os métodos histológico e molecular, em metaplasia intestinal (p = 0,0461 e adenocarcinoma gástrico (p = 0,0011, devido à subdetecção do H. pylori pelo método histológico, e provavelmente pela baixa densidade da bactéria conseqüente à atrofia severa da mucosa gástrica, nesses dois tipos de lesões. Nossos achados demonstram que o método de PCR é mais eficaz para diagnosticar a infecção por H. pylori, principalmente, em metaplasia intestinal e adenocarcinoma gástrico.

  12. Prospective analysis of clinician accuracy in the diagnosis of benign anorectal pathology: the value of clinical information Análisis prospectivo de la precisión diagnóstica en la patología anorrectal benigna: importancia de la información clínica

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    Jaime Jimeno

    2012-03-01

    Full Text Available Aim: the prevalence of anorectal disorders in general population is high. The aim of this study was to analyze the influence of clinical symptoms on diagnostic accuracy for benign anorectal pathology among different specialists and evaluate the relationship between diagnostic accuracy and years of professional experience. Methods: seven typical cases were selected. In a first interview, participants were shown images and asked to make a diagnosis. Afterwards, images with additional information (clinical symptoms were used. Two groups (group 1 = general surgeons and group 2 = medical specialists who attended emergency department completed both phases of the study to analyze the influence of clinical symptoms on the final diagnosis. Results: forty four specialists were interviewed. The percentage of participants making a correct diagnosis in groups 1 and 2, respectively, was as follows: case 1 (perianal abscess: 100 vs. 80.6%, (p = 0.157; case 2 (fissure: 92.3 vs. 51.6% (p = 0.015; case 3 (thrombosed hemorrhoid: 92.3 vs. 74.2% (p = 0.321; case 4 (anal condyloma: 100 vs. 87.1% (p = 0.302; case 5 (rectal prolapse: 100 vs. 83.9% (p = 0.301; case 6 (prolapsed hemorrhoid: 92.3 vs. 29% (p = 0.001, and case 7 (fistula: 100 vs. 67.7% (p = 0.021. There were significant differences in the number of correctly diagnosed cases between groups (p Objetivo: la prevalencia de los trastornos anorrectales benignos en la población general es alta. El objetivo de este estudio es analizar la influencia de los síntomas clínicos en la precisión diagnóstica de la patología benigna anorrectal entre los diferentes especialistas y evaluar la relación entre el diagnóstico de la enfermedad y los años de experiencia profesional entre los profesionales participantes. Pacientes y métodos: se seleccionaron 7 casos típicos. En una primera entrevista, se mostró a los participantes las imágenes clínicas de cada caso y se les pidió que formularan un diagn

  13. Blood in the Urine (Hematuria) (For Parents)

    Science.gov (United States)

    [Skip to Content] for Parents Parents site Sitio para padres General Health Growth & Development Infections Diseases & Conditions Pregnancy & Baby Nutrition & Fitness Emotions & Behavior School & Family ...

  14. Benign childhood epilepsy with centro-temporal spikes: correlation between clinical, cognitive and EEG aspects Epilepsia benigna da infância com pontas centrotemporais: correlação entre aspectos clínicos, eletrencefalográficos e cognitivos

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    Lineu Corrêa Fonseca

    2007-09-01

    Full Text Available Benign childhood epilepsy with centro-temporal spikes (BECTS is a form of epilepsy with no demonstrable anatomical lesion showing spontaneous seizure remission. During the active phase of the disease the children may show cognitive deficits. The objective of this study was to assess, in children with BECTS, the relationship between clinical-EEG aspects and performance in the school performance test (SPT, Raven's progressive matrixes test and the Wechsler Intelligence Scale for Children (WISC-III. Forty-two 7 to 11 year old children were included and the following tests carried out: anamnesis, neurological examination, electroencephalogram (EEG, SPT, Raven's test and WISC-III. The children with BECTS had normal IQ values but showed inferior performance in the SPT more frequently than "healthy" children, paired with respect to age and maternal scholastic level. There was moderate positive correlation between WISC-III results and the age when the seizures started and the educational level of the parents. On the other hand, aspects linked to the epileptic nature of BECTS, such as the number of seizures, time since last seizure and the number and lateralization of the centro-temporal spikes on the EEG, showed no correlation with the neuropsychological tests.A epilepsia benigna da infância com pontas centrotemporais (EBICT é uma forma de epilepsia na qual não existem lesões anatômicas demonstráveis e há remissão espontânea das crises. Na fase ativa da epilepsia as crianças podem apresentar déficits cognitivos. O objetivo deste estudo foi avaliar, em crianças com EBICT, a relação entre aspectos clínico-eletrencefalográficos e o desempenho no teste de desempenho escolar (TDE, no teste das matrizes progressivas de Raven e na Escala Wechsler de Inteligência para Crianças (WISC-III. Foram incluídas 42 crianças de 7 a 11 anos de idade. Foram realizados: anamnese, exame neurológico, eletrencefalograma (EEG, TDE, teste de Raven e WISC

  15. Importância do dismorfismo eritrocitário na investigação da origem da hematúria: revisão da literatura The importance of the dysmorphic erythrocyte for investigation of the source of hematuria: literature review

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    Leonardo de Souza Vasconcellos

    2005-04-01

    Full Text Available As hematúrias são achados comuns nos exames de urina de rotina e nem sempre são sinais de doenças. A presença de hematúria associada a outras alterações urinárias, especialmente a proteinúria, sugere comprometimento do trato urinário e merece investigação. Na literatura são inúmeros os trabalhos que valorizam a sedimentoscopia urinária, principalmente a morfologia das hemácias, como indicativo do local do sangramento: se glomerular ou não-glomerular. Neste artigo, os autores revisam o estudo do dismorfismo eritrocitário, enfatizando a definição, a fisiopatologia, os métodos, os valores de referência e as limitações apontadas na literatura. As comparações com demais marcadores de hemorragia glomerular também foram discutidas. No final, os autores relatam como a literatura interpreta e utiliza os resultados da pesquisa do dismorfismo eritrocitário para guiar a propedêutica complementar na investigação da origem da hematúria.The hematurias are a frequent finding in urinary routine exams and do not necessarily indicate illness. The presence of hematuria associated with other urinary disturbances, especially proteinuria, indicates urinary tract pathology and should be investigated. In the literature, several studies point out the importance of urinary sedimentoscopy, specially the red cells morphology, to determine the source of bleeding: glomerular or non-glomerular. In this article, the authors review the dysmorphic erythrocyte, emphasizing on the meaning, the physiopathology, the methods, the cut-of values, and the limitations according to the literature. The comparisons with other markers of glomerular bleeding were also discussed. At the end, the authors exposed how the literature analyses and applies the dysmorphic erythrocyte results to guide the complementary research for investigation the source of urinary bleeding.

  16. Manuseio anestésico de paciente portador de telangiectasia hemorrágica hereditária (síndrome de Rendu-Osler-Weber: relato de caso Manoseo anestésico de paciente portador de telangiectasia hemorrágica hereditaria (síndrome de Rendu - Osler - Weber: relato de caso Anesthetic management of a patient with hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome: case report

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    Alexandre Palmeira Goulart

    2009-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A telangiectasia hemorrágica hereditária (THH, também conhecida como síndrome de Rendu-Osler-Weber, é uma doença autossômica dominante, caracterizada por displasia vascular mucocutânea e visceral associada a episódios freqüentes de epistaxe e sangramentos gastrintestinais. O objetivo do presente relato foi descrever a anestesia em paciente portador dessa síndrome. RELATO DO CASO: Paciente do sexo masculino, 25 anos, submetido à correção cirúrgica de fratura de órbita esquerda. Portador da tríade epistaxe recorrente, histórico familiar e telangectasia, apresentava diagnóstico de THH. Durante a investigação pré-operatória não foram encontradas malformações vasculares pulmonares, encefálicas ou do trato gastrintestinal. O paciente foi submetido à anestesia venosa total, uma hora após a administração profilática de antifibrinolítico. O sangramento foi considerado normal para a operação proposta e não houve instabilidade hemodinâmica ou necessidade de transfusão sanguínea perioperatória. A extubação ocorreu na sala cirúrgica e o paciente foi liberado para o quarto após 60 minutos e a alta hospitalar foi após 24 horas. CONCLUSÕES: A THH é uma doença autossômica dominante que provoca displasia vascular musculocutânea e visceral. Pode haver perda sanguínea perioperatória acima da esperada para pacientes portadores dessa síndrome. Como o sangramento não é resultado de defeito na cascata de coagulação mas da exposição cirúrgica da estrutura vascular malformada, a conduta perioperatória inclui o emprego de antifibrinolíticos, a realização de hemostasia adequada e da hipotensão arterial induzida, quando não houver contra-indicação. A avaliação pré-anestésica deve incluir a pesquisa de malformações vasculares encefálicas, pulmonares ou do trato gastrintestinal.JUSTIFICATIVA Y OBJETIVOS: La telangiectasia hemorrágica hereditaria (THH, también conocida como

  17. Las mutaciones inestables, nuevo reto para el consejo genético de enfermedades hereditarias

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    Patricia Cuenca

    2004-09-01

    Full Text Available Las mutaciones inestables constituyen un tipo de alteración genética descubierta en la década de los noventa. En condiciones normales, regiones específicas de los genes están constituidas por repeticiones de una secuencia corta que puede ser de tres, cuatro, cinco o más nucleótidos; por ejemplo CAG, CGG, ATTCT, etc. Este nuevo tipo de mutación consiste en un aumento en la cantidad de éstas repeticiones, lo que causa una alteración en la expresión de dichos genes. Son inestables porque se ha observado que el tamaño de la secuencia repetida varía cuando las células se dividen por mitosis o meiosis, lo cual tiene implicaciones sobre la herencia y por consiguiente sobre el consejo genético que debe brindarse a los afectados. Estas mutaciones se han encontrado en genes importantes para la función neurológica normal del ser humano, donde pueden alterar el transporte de los ARN desde el núcleo al citoplasma, provocar la inactivación del gen o producir una proteína con funciones nuevas. La mayoría de las enfermedades causadas por estas mutaciones afectan el sistema nervioso, son degenerativas y presentan el fenómeno de anticipación genética, es decir que los afectados dentro de una familia se enfermarán más jóvenes y en forma más severa con el paso de las generaciones. La cantidad de repeticiones de la secuencia repetida presenta una correlación negativa con la edad de manifestación, así como una correlación positiva con la severidad de la enfermedad. En este momento existen veinte padecimientos identificados que son causados exclusivamente por este tipo de mutación. Este trabajo es una breve revisión actualizada del tema.Unstable mutations, new challenges for genetic counseling of inherited disorders. Unstable mutations or amplification of DNA tandem repeats sequences constitute a new kind of genetic alteration discovered in the 90´s that cause hereditary diseases. This mutation has been found inside or near important genes involved in the normal neurological function in human beings. In some cases, the presence of the amplification causes altered expression of the genes, their inactivation or the synthesis of a protein with new functions. Some common characteristics of these diseases are that they affect the central nervous system and are degenerative in nature. Most of them show genetic anticipation meaning that the severity of the manifestations increases in each generation and appear at an earlier age. In most cases, the severity of the symptoms is positively correlated with the size of the amplification. Twenty illnesses caused by this kind of mutations have been identified so far. Briefly, this work reviews the current knowledge about this topic. Rev. Biol. Trop. 52(3: 491-499. Epub 2004 Dic 15.

  18. Esferocitosis hereditaria: experiencia clínica y diagnóstica en Argentina

    OpenAIRE

    Crisp, Renée Leonor; García, Eliana; Solari, Liliana; Rapetti, María Cristina; Nesse, Alcira; Donato, Hugo

    2017-01-01

    Los objetivos del presente estudio fueron: a) Analizar las características demográficas y clínicas de nuestra población al diagnóstico; b) Evaluar si las pruebas más recientes presentan ventajas sobre las tradicionales; c) Confirmar la frecuencia de las distintas deficiencias de proteínas de membrana; d) Establecer la relación entre severidad y resultado de las pruebas o tipo de deficiencia. Se analizaron 359 individuos estudiados desde 2007, cuando se incorporaron criohemólisis hipertónica (...

  19. [Stickler's syndrome (dystrophia vitreoretinalis hereditaria). Results of surgery for retinal detachment].

    Science.gov (United States)

    Karel, I; Dolezalová, J; Oudová, P

    2001-05-01

    Stickler's syndrome (SS) is an autosomal dominant hereditary disease of the collagenous connective tissue where impaired development of the vitreous body gel and peripheral retina and detachment of the retina are associated with general manifestations. The objective of the retrospective study was to evaluate the long-term results of surgery of retinal detachment in SS. The group of patients comprised 7 patients, 6 men and 1 woman aged 4 to 45 years, average age 16.8 years. Autosomal dominant heredity was obvious in 6 members (85.7%) of two families. General manifestations of SS included abnormalities of the facial skeleton (6 patients), cleft palate (4 patients), impaired hearing (2 patients), marfanoid habitus (2 patients) and hyperextensibility of the joints (4 patients). In the eyes with SS was manifested by myopia from -1 to -9 D and a liquid vitreous body. Multiple foci of lattice degeneration supplemented the finding in 6 patients (85.7%). Detachment of the retina was a manifestation of SS in 12 of 14 eyes (85.7%). It was manifested in 5 of 7 patients concurrently or within 12 years in both eyes. The causes of retinal detachment were multiple equatorial and postequatorial tears due to lattice degeneration in 8 eyes (66.7%) or a giant tear in 4 eyes (33.3%). Advanced proliferative vitreoretinopathy (PVR) was associated with retinal detachment in 8 eyes (66.7%) and in 6 eyes (50%) it was not possible to assess the beginning of retinal detachment. In 3 of 5 patients with bilateral retinal detachment the adverse course of retinal detachment on the first eye was followed 8 to 12 years previously in another department: two retinal detachments with giant tears were evaluated as inoperable and one inveterated detachment with advanced PVR was operated unsuccessfully. Retinal detachment was operated in 9 eyes of 7 patients, in two patients both eyes were operated simultaneously. The patients were followed up after surgery for 11 months to 15 years, on average for 65 months. A cryosurgical approach was used in 6 retinal detachments (66.7%), accentuated cerclage with drainage of subretinal fluid in 5 and radial plombage in one eye. The retina attached in 5 of 6 eyes (83.3%) and the final visual acuity was 0.25-0.1, mean 0.66. Pars plana vitrectomy (PPV) and implantation of silicone oil (ISO) were the final surgical solution in 3 eyes of 3 patients (33.3%). In one eye with retinal detachment with a circumferential width of 320 degrees and advanced PVR PPV and ISO were the primary operation, in two eyes re-operation on account of a relapse of retinal detachment with advanced PVR after an unsuccessful cryosurgical operation. Anatomical and functional success was achieved in 2 of 3 eyes (66.7%), in one eye after removal of silicone oil from the eye. The final visual acuity of successfully operated eyes was 0.2 and 0.16. Retinal detachment in SS usually affects both eyes, the second eye may be affected after many years. The cause of retinal detachment are multiple tears or a giant tear. Early surgery of retinal detachment has as a rule a favourable effect, while late diagnosis of retinal detachment in children leads frequently to blindness. Dispensarization and regular ophthalmological check-ups of patients with SS are an essential prerequisite of successful prevention and treatment of retinal detachment.

  20. Tiroidectomia total en afecciones benignas de la glándula tiroides.

    OpenAIRE

    Lucena Olavarrieta, Jorge R.; Coronel, Paúl; Orellana, Ysabelen

    2006-01-01

    Editorial. ¡Ya tenemos símbolo, ícono o logotipo!. Now we have symbol, icono or logo!. Salinas, Pedro José Accidentes domésticos en ancianos. Municipio Libertador. Mérida. 1993-1996. Domestics accidents in elderly people. Libertador County of Mérida State. 1993-1996. Salinas, Pedro José Rojas Márquez, Reina Estrés y síntomas en personal de salud del Hospital Universitario de Los Andes. Stress and symptoms in health staff of the Hospital Universitario de Los Andes. Méri...

  1. Hipertrofia benigna do músculo masseter Benign masseter muscle hypertrophy

    Directory of Open Access Journals (Sweden)

    Daniel Zeni Rispoli

    2008-10-01

    Full Text Available A hipertrofia idiopática do músculo masseter (HIM é uma patologia pouco freqüente e de causa desconhecida. Alguns autores correlacionam tal condição com hábitos de mascar gomas, disfunção da articulação temporomandibular (ATM, hipertrofias congênitas e funcionais, e distúrbios emocionais (nervosismo e ansiedade. A maioria dos pacientes queixa-se da alteração estética decorrente da assimetria facial, também chamada "face quadrada", no entanto, sintomas como trismo, protrusão e bruxismo também podem ocorrer. Os objetivos deste estudo foram: relatar um caso de HIM e descrever a sintomatologia e o tratamento realizado. O paciente relatava aumento bilateral na região do ângulo da mandíbula de evolução lenta e progressiva. Negava dor ou desconforto, porém se queixava de otalgia bilateral, trismo noturno e ansiedade. Ao exame físico, observou-se hipertrofia bilateral de masseter sem alterações inflamatórias no local. Foi indicado tratamento cirúrgico com abordagem extra-oral. Exames complementares são indicados na dúvida diagnóstica. A conduta terapêutica varia de conservadora a cirúrgica, sendo que esta depende principalmente da experiência e da habilidade do cirurgião.Idiopathic hypertrophy of the masseter muscle is a rare disorder of unknown cause. Some authors associate it with the habit of chewing gum, temporo-mandibular joint disorder, congenital and functional hypertrophies, and emotional disorders (stress and nervousness. Most patients complain of the cosmetic change caused by facial asymmetry, also called square face, however, symptoms such as trismus, protrusion and bruxism may also occur. The goals of the present investigation were: to report a case of idiopathic masseter hypertrophy, describe its symptoms and treatment. The patient reported bilateral bulging in the region of the mandible angle, of slow and progressive evolution. He did not complain of pain or discomfort, however there was bilateral otalgia, nighttime trismus and stress. In his physical exam we noticed bilateral masseter hypertrophy without local inflammatory alterations. We indicated surgical treatment with an extraoral approach. Complementary tests are indicated when there is diagnostic doubts. Treatment varies from conservative to surgical, and the later depends on surgeon skill and experience.

  2. Pharmacological treatment of the benign prostatic hyperplasia; Tratamiento farmacologico en la hiperplasia prostatica benigna

    Energy Technology Data Exchange (ETDEWEB)

    Perez Guerra, Yohani; Molina Cuevas, Vivian; Oyarzabal Yera, Ambar; Mas Ferreiro, Rosa, E-mail: yohani.perez@cnic.edu.c [Centro de Productos Naturales, Centro Nacional de Investigaciones Cientificas (CNIC), La Habana (Cuba)

    2011-07-01

    Benign prostatic hyperplasia is a common disease in over 50 years-old men consisting in uncontrolled and benign growth of prostatic gland that leads to lower urinary tract symptoms. The etiology of benign prostatic hyperplasia is multifactoral involving the increased conversion of testosterone in dihydrotestosterone by the prostatic 5{alpha}-reductase action, which brought about events that encourage the prostate growth (static component) and the increase of the bladder and prostate smooth muscle tone (dynamic component) regulated by the a{alpha}{sub 1} -adrenoceptors (ADR). The pharmacological treatment of the benign prostatic hyperplasia includes the prostatic 5a{alpha}-reductase inhibitors, the a{alpha}{sub 1}-adrenoreceptor blockers, their combined therapy and the phytotherapy. This paper was aimed at presenting the most relevant aspects of the pharmacology of drugs used for treating the benign prostatic hyperplasia, and providing elements to analyze their efficacy, safety and tolerability. To this end, a review was made of the different drugs for the treatment of this pathology and they were grouped according to their mechanism of action. Natural products were included as lipid extracts from Serenoa repens and Pygeum africanum as well as D-004, a lipid extract from Roystonea regia fruits, with proved beneficial effects on the main etiological factors of benign prostatic hyperplasia. D-004 is a prostatic 5a-reductase inhibitor, an a{alpha}{sub 1}-adrenoceptor antagonist, a{alpha} 5-lipooxygenase inhibitor and has antioxidant action, all of which reveals a multifactoral mechanism. The results achieved till now indicate that D-004 is a safe and well-tolerated product

  3. Endometriose intestinal: uma doença benigna? Bowel endometriosis: a benign disease?

    Directory of Open Access Journals (Sweden)

    Marco Antonio Bassi

    2009-01-01

    Full Text Available A despeito do caráter benigno da endometriose, estima-se que 1% dos casos esteja relacionado com câncer, especialmente quando ambas as condições ocorrem nos ovários. Lesões extra-ovarianas encontradas no septo retovaginal, cólon, bexiga, vagina e peritônio da região pélvica também já foram associadas com neoplasias malignas. Várias características do tecido endometrial ectópico o aproximam do fenótipo neoplásico, e a própria endometriose possui comportamento tipicamente neoplásico com capacidade de invasão do estroma adjacente e associação com lesões à distância. Esta revisão atualiza conhecimentos diagnósticos, clínicos e terapêuticos dos implantes intestinais de tecido endometriótico, bem como sua relação com processos neoplásicos para melhor compreensão de seu caráter benigno ou de seu eventual potencial para malignidade.Endometriosis is generally assumed to be a benign disease, but it is estimated that 1% of cases are associated with cancer, especially when both conditions are present in the ovary. Extra-ovarian lesions in the rectovaginal septum, colon, bladder, vagina and peritoneum were already associated with malign neoplasia. Several characteristics of endometrial tissue are very similar to the neoplasia phenotype. Endometriosis itself typically behaves as a neoplasia process, spreading over adjacent stroma and being associated with distant lesions. This is an update on the diagnostic, clinical, and therapeutic knowledge of, management of bowel implants of endometrial tissue, as well as the relation with neoplastic processes to better understand its benign nature or eventual potential for malignancy.

  4. Amiloidosis renal hereditaria por depósito de apolipoproteína AI: un reto diagnóstico

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    Kelly del Rocío Samillán-Sosa

    2015-05-01

    La amiloidosis por depósito de Apo AI progresa a enfermedad renal crónica terminal en el plazo de de 3 a 15 años. Se diferencia clínicamente de la amiloidosis AL por su menor afectación extrarrenal y su mejor pronóstico. El trasplante renal ofrece una supervivencia del injerto aceptable y el trasplante hepato-renal se podría tener en cuenta en pacientes con disfunción significativa de ambos órganos.

  5. Transmisión hereditaria a través de la mujer en la Grecia clásica

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    Jesús Cepeda

    2000-01-01

    Full Text Available La mujer en Grecia durante el período clásico, poseía una serie de derechos legales y económicos que la colocaban bajo la tutela de un hombre a lo largo de toda su vida, bien fuera su padre o posteriormente su marido, quién administrará en su nombre su dinero y bienes. Se analizan las distinas disposiciones legales de la mujer en Atenas, en claro contraste con las de la mujer en Esparta o en Gortina.The greek woman during the classic period, she had legal and economic rights that she was always under a guardián during all her life, firstly her father and secondly under her husband, that he will manage money and properties in her name. In this study the different legal rights are analyzed, in sharp difference with the legal rights of the Spartan woman and even the woman in Gortina.

  6. Benign monomelic amyotrophy: a study of twenty-one cases Amiotrofia monomélica benigna: estudo de 21 casos

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    MARCOS R.G. DE FREITAS

    2000-09-01

    Full Text Available A consecutive series of 21 patients with single limb atrophy (monomelic amyotrophy is reported. Sixteen had lower limb atrophy and five had upper limb involvement. The median age of the onset was 20 years. Characteristic features were sporadic occurrence, wasting confined to one limb, insidious onset with slow progression, stabilizing in 1 to 4 years, and absence of pyramidal signs. All the patients with upper limb involvement were male, however in our cases with lower limb amyotrophy there were no male preponderance. We observed wasting of the entire length of the lower limbs in six patients. There were nine cases with amyotrophy restricted to the leg and one with amyotrophy only in the thigh. In the upper limb in four cases the involvement was distal and in one patient the atrophy was proximal. The electromyographic features were suggestive of anterior horn disease not only in the affected limb but also, in some cases, in clinically uninvolved limb. Cervical or lumbar MRI was normal. MRI of the lower limb disclosed increased signal intensity in the gastrocnemius and soleus muscles in one patient suggesting denervation.Relatamos uma série consecutiva de 21 pacientes com amiotrofia de um só membro, denominada de amiotrofia monomélica. Em 16 casos a atrofia era no membro inferior e em 5 localizava-se no membro superior. Todos eram jovens e a idade média do início foi 20 anos. Os dados mais característicos da doença foram ausência de história familiar, comprometimento de um só membro, início e progressão lenta estabilizando em até 4 anos e ausência de sinais piramidais. Nossos enfermos com amiotrofia de membro superior eram todos do sexo masculino, entretanto naqueles com amiotrofia do membro inferior havia igualdade de sexos. Dos pacientes com atrofia de membro inferior, em 9 a atrofia era restrita a perna, em 6 era em todo o membro e somente um apresentava amiotrofia localizada só na coxa. Naqueles com comprometimento do membro superior a atrofia era distal em 4 e proximal em 1. Os achados na eletromiografia foram compatíveis com acometimento do II neurônio motor. Todos foram submetidos a RM da coluna cervical ou lombar que se mostrou normal. Em um caso realizamos RM da perna acometida que evidenciou sinais hiperintensos nos músculos gastrocnemius e soleus, o que sugere desnervação.

  7. Estenosis esofágicas benignas: tratamiento con las bujías de Savary-Gilliard

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    Trini Fragoso Arbelo

    2001-09-01

    Full Text Available Se estudiaron 60 pacientes menores de 15 años con estenosis esofágica, 40 de ellos por ingestión de cáusticos y 20 por otras causas, susceptibles de tratamiento de dilatación endoscópica. Esta se realizó bajo anestesia general con un endoscopio GIF-XP10 de la casa Olympus y bajo pantalla fluoroscópica con las bujías de Savary-Gilliard modelo pediátrico. En las estenosis esofágicas secundarias a ingestión de cáustico se asoció al tratamiento inyectoterapia endoscópica con betametasona. El 66,6 % de la serie fue por ingestión de cáustico y en segundo lugar las ocurridas por causas posquirúrgicas, para el 20 %. El 70 % de las poscáusticos se clasificó según radiografía como severo. La localización más frecuente de las estenosis fue el tercio superior del esófago, con predominio de la variedad tubular en las debidas a cáusticos, y la anular en las otras causas. En las poscáusticos se realizaron 919 dilataciones en 288 sesiones, mientras que en las originadas por otras causas se efectuaron 223 en 67 sesiones. Como complicación se reportan 8 perforaciones, 1 sepsis y 3 seudodivertículos en el grupo de los cáusticos. No se observó mortalidad. El grupo secundario a cáustico necesitó mayor número de sesiones y de dilataciones promedio con respecto al otro grupo y con el 47,5 % de curación y el 95 % en las de otras causas. Se demostró que el método de dilataciones esofágicas de Savary-Gilliard es seguro, eficaz y con un mínimo de complicaciones.60 patients under 15 with esophageal stenosis, 40 of them due to caustic ingestion and 20 by other causes, susceptible to the treatment of endoscopic dilatation, were studied. It was performed with general anesthesia, using an Olympus GIF-XP10 endoscope and under fluoroscopic screen with Savary-Gilliard bougies, pediatric model. In the esophageal stenoses secondary to caustic ingestion, endoscopic betamethasone injection therapy was associated with the treatment. 66.6 % of the series were caused by caustic ingestion, whereas 20 % were due to postsurgical causes. 70 % of the postcaustic ingestion group were classsified as severe according to X-rays. The most frequent localization of stenosis was the upper third of the esophagus with predominance of the tubular variety among those caused by caustic ingestion and of the annulate variety in the other causes. In the postcaustic ingestion group, 919 dilatations were carried out in 288 sessions, whereas 223 were performed in 67 sessions in those originated by other causes. 8 perforations, 1 sepsis and 3 pseudodiverticula were reported as complications in the group that ingested caustics. There was no mortality. Those who ingested caustics needed a higher average number of sessions and dilatations than the other group. 47.5 % of them were cured in this group, whereas 95 % healed in the other group. It was proved that Savary-Gilliard method of esophageal dilatations is safe, efficient and has a minimum of complications.

  8. Atrofia muscular proximal neurogenica hereditaria (doença de Wohlfart-Kugelberg-Welander: estudo clinico, eletromiografico e anatomo-patologico de 3 irmãos

    Directory of Open Access Journals (Sweden)

    Marcos R. G. de Freitas

    1976-03-01

    Full Text Available Os autores relatam os casos de três irmãos com fraqueza e amiotrofia proximal dos membros de início na infância. Os estudos eletromiográficos e de biópsias musculares revelaram alterações do tipo neurogênico de permeio com alterações miogênicas. Fazem consideração sobre esta singular associação, considerando as alterações do tipo miopático como secundárias à denervação de longa duração. O estudo histopatológico medular, em um dos pacientes, revelou degeneração das células motoras das pontas anteriores, constituindo, assim, o 4.° estudo de autópsia da doença de Wohlfart-Kugelberg-Welander, na literatura.

  9. Simulación por computador de un modelo para el análisis de la estrategia matrimonial y hereditaria en una comunidad mediterránea

    Directory of Open Access Journals (Sweden)

    RICARDO SANMARTÍN ARCE

    1980-01-01

    Full Text Available Tras comparar una comunidad pesquera de la Albufera (Valencia con otras comunidades pesqueras del Mediterráneo, llamó la atención la escasez de matrimonios entre primos, teniendo en cuenta que los matrimonios en dichas comunidades son numerosos. Se plantean dos hipótesis explicativas: la multiplicación y diversificación de los vínculos locales entraña cuantiosas ventajas, teniendo en cuenta el marco comunal en que se desarrollan las tareas de pesca y el cultivo individual de arroz; el matrimonio es la única institución que garantiza la transmisión de los derechos de pesca. Se verifica la segunda hipótesis mediante la aplicación de un modelo estadístico de probabilidad. El modelo combina las regla de herencia con la frecuencia real de herencias en el matrimonio. El programa se empleó con el objetivo de completar una simulación informática que agotó las posibilidades lógicas del modelo, demostrando de este modo las ventajas relativas del matrimonio y del no-matrimonio entre primos. Los resultados indican el impacto despreciable de las posibilidades de herencia en las estrategias de matrimonio. La diferencia entre la simulación y la realidad empírica ilustra la importancia de las normas en el comportamiento.

  10. External hydrocephalus (benign extra-axial collections of infancy) - review of 15 cases; Hidrocefalia externa colecao extra-axial benigna da infancia - revisao de 15 casos

    Energy Technology Data Exchange (ETDEWEB)

    Machado Junior, Marcos Alberto da Costa; Matos, Paulo Engracio de; Barbosa, Veronica Aline [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael. Servico de Bioimagem; Vieira, Naiara Argollo [Hospital Salvador, BA (Brazil); Vieira, Lauro Conceicao Nascimento [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael. Servico de Ressonancia Magnetica; Puglio, Nadja; Bacelar, Aroldo [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael

    1997-03-01

    The authors studied 15 cases of external hydrocephalus over a 7-year period (September 1987 to May 1995). External hydrocephalus is a condition in which infants with rapidly enlarging heads are found to have a MRI showing widening of subarachnoid space with mild or no ventricular dilatation. Some of the MRI were compared with those of patients with cerebral atrophy and some etiopathogenic hypothesis are presented. These findings indicate that external hydrocephalus is an age-related self-limited condition occurring in infants with open cranial sutures and that it usually resolves without intervention after the second or third year of age. (author) 21 refs., 4 figs.

  11. La maca roja (Lepidium Meyenii) y su acción en el tratamiento de la hiperplasia prostática benigna

    OpenAIRE

    Alvarado Alvarado, Jesenia Ludy; Alvarado Alvarado, Jesenia Ludy

    2015-01-01

    La Maca (Lepidium Meyenii) es una valiosa raíz de reserva, llamada hipocólito, utilizada como alimento y sobre todo como remedio natural desde los tiempos de los incas. Nativa del Perú, la Maca se ha extendido por todo el mundo como planta medicinal, y aparece citada en la medicina Herbal Peruana para estimular el sistema inmunitario, tratar la anemia, la tuberculosis, los desórdenes menstruales, los síntomas de la menopausia, aumentar la fertilidad, como afrodisiaco, para tratar la disfun...

  12. Wicket spikes: a case-control study of a benign eletroencephalografic variant pattern "Wicket spikes": estudo de variante eletrográfica benigna

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    MARCUS SABRY AZAR BATISTA

    1999-09-01

    Full Text Available Wicket spikes (WS are a benign eletroencephalogram (EEG variant, seen mainly in adults, during somnolence, in the temporal regions, in many clinical situations. WS can appear in trains or isolatedly, sometimes being difficult to differentiate from epileptiform activity. We reviewed 2,000 EEG's, found 65 with WS (3.25% and compared them with 65 normal EEG without WS. There was statistically significant (SS association between WS and age over 33; adolescent age was correlated to absence of WS and age over 65, to the presence of WS; there was an inverse correlation between WS and epilepsy, related to differences in age; a SS association with cerebrovascular disorders disappeared after controlling for age; a SS correlation with headache was also related to age; female predominance was not SS. There was a great variety of clinical situation associated with WS. We conclude that WS are a inespecific normal variant of the EEG that is age-related.As Wicket spikes (WS são um padrão benigno, variante da normalidade do eletrencefalograma (EEG, vistas principalmente em adultos, durante a sonolência, nas regiões temporais, em situações clínicas variadas. WS aparecem em "trens" ou isoladamente, podendo ser difícil diferenciá-las de atividade epileptiforme. Nós revisamos 2.000 EEG e encontramos 65 com WS (3,25% e os comparamos a 65 EEG 's normais sem WS. Encontramos associação estatisticamente significante (ES entre WS e idade acima de 33 anos; adolescência e ausência de WS e idade acima de 65 e presença de WS. Houve correlação inversa entre WS e epilepsia, explicada por diferenças nas médias de idade. A correlação ES entre WS e doença cerebrovascular desapareceu após controlarmos a idade. A correlação ES a cefaléia dependeu de sua relação à idade. A predominância do sexo feminino não foi ES. Houve maior variedade de situações clínicas associadas a WS. WS são uma variante normal do EEG, idade-relacionada.

  13. Extirpación de lesiones epiteliales benignas en la lengua, durante el periodo de gestación. Reporte de dos casos

    OpenAIRE

    Martínez de Páez, Norma A.; Bermúdez Rodríguez, José Rafael

    2009-01-01

    Las estructuras anatómicas que rodean la cavidad oral están cubiertas por una membrana formada por epitelio plano estratificado. El epitelio sirve de protección para los tejidos blandos orales y también de barrera para evitar el paso de factores patógenos externos. En la mucosa bucal pueden presentarse varios tipos de lesiones, unas de ellas conocidas en clínica como lesiones verrugosas–papilares, son de crecimiento exofítico benigno, las cuales pueden originarse en cualquier parte de la muco...

  14. Esplenectomía laparoscópica

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    Pedro L Vilorio Haza

    2001-09-01

    Full Text Available La esplenectomía laparoscópica (EL ofrece las ventajas de la cirugía laparoscópica. La mejor indicación de la EL la constituyen las enfermedades hematológicas benignas. Desde octubre de 1996 hasta agosto del 2000 se intentaron realizar 22 esplenectomías por el método laparoscópico. Las indicaciones más frecuentes fueron las enfermedades hematológicas benignas: la púrpura trombocitopénica idiopática en 9 pacientes, la microesferocitosis hereditaria en 4, la anemia hemolítica autoinmune en 5, la estadiación del linfoma de Hodgkin en 2, 1 caso de tumor quístico del bazo y 1 caso de hiperesplenismo sin causa demostrada. Se analizan los resultados en estos primeros 22 casos y se describe la técnica quirúrgica. La edad promedio fue de 34,3 años, con rango de 16 a 73 años. El tiempo quirúrgico promedio fue de 147 min. Se convirtieron a cirugía abierta 4 pacientes por sangrado transoperatorio. Ocurrieron accidentes operatorios en 4 pacientes. No se presentaron complicaciones posoperatorias. El proceder se asoció con colecistectomía laparoscópica en 6 pacientes y biopsia de ganglio mesentérico con biopsia hepática en 2 pacientes. El sangrado transoperatorio promedio fue de 467 mL. La EL es una técnica reproducible y segura que brinda las ventajas de la cirugía laparoscópica (menor morbilidad y mortalidad posoperatoria, sobre todo en las enfermedades hematológicas benignas con bazo de tamaño normal o esplenomegalia no mayor de 25 cm, a pesar del efecto negativo de la curva de aprendizajeThe laparoscopic splenectomy (LS offers the advantages of the laparoscopic surgery. The best indication of LS are the bening hematological diseases. 22 splenectomies were performed by the laparoscopic method from October, 1996, to August, 2000. The most frequent indications were the bening hematological diseases: idiopathic thrombocytopenic purpura in 9 patients, hereditary microspherocytosis in 4, autoimmune hemolitic anaemia in 5, Hodgkin

  15. Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá

    OpenAIRE

    Muñoz Cuéllar, Juan Manuel

    2017-01-01

    Introducción: Las distrofias retinianas son determinadas genéticamente e implican una gran variabilidad fenotípica y genotípica. En Iberoamérica hay poca literatura sobre sus aspectos fenotípicos, genotípicos y epidemiológicos. Metodología: Se realizó un estudio descriptivo a 2 años, con captación en las 3 consultas de retina más importantes de la Ciudad de Panamá. Resultados: Se encontró una incidencia de 5 pacientes por año, e incidencia acumulada de 5,35:10.000 en las consultas púb...

  16. Estudio genético de distrofias hereditarias de retina: Desarrollo de una estrategia combinada para el diagnóstico de las formas recesivas y esporádicas de retinosis pigmentaria

    OpenAIRE

    Cantalapiedra de la Fuente, Diego

    2015-01-01

    La Retinosis Pigmentaria Autosómica Recesiva (RPAR) constituye una de las causas más importantes de ceguera en nuestra sociedad. Se caracteriza por la degeneración progresiva de las células fotorreceptoras de la retina, y los pacientes generalmente presentan ceguera nocturna, seguida de constricción del campo visual periférico. Esta enfermedad conlleva un alto coste social y humano, pues aún no existe un tratamiento eficaz. En conjunto, afecta aproximadamente a 1 de cada 3000 personas en todo...

  17. Histopathological aspects of Bovine Enzootic Hematuria in Brazil Aspectos histopatológicos da Hematúria Enzoótica Bovina no Brasil

    Directory of Open Access Journals (Sweden)

    Paulo Vargas Peixoto

    2003-06-01

    Full Text Available The bladder lesions of 59 cattle, from the States of Rio de Janeiro, São Paulo, Minas Gerais, Espírito Santo, Rio Grande do Sul, Santa Catarina, Paraná and Amazon, affected by Bovine Enzootic Haematuria (BEH, were studied histologically. The objective of this study was to describe and reclassify neoplastic and non-neoplastic alterations not yet reported, according to the more complete current nomenclature used in human medicine. There was an almost complete identity with alterations observed in the bladder of man. Due to the occurrence of two or more neoplasms in the same animal, differences in the methodology and in the concept of classification, a more precise comparison was not possible. Coexistence of different types of epithelial and/or mesenchymal tumour growth was frequently seen. Rare neoplasms or differentiations not previously described were found in the bladder of some animals affected by BEH. These were trabecular carcinoma with Paneth cells differentiation, mesonephroid adenoma, mesonephroid adenocarcinoma, "signet ring" cell carcinoma, plasmocytoid carcinoma, chromophobe cell carcinoma and nested type of transitional cell carcinoma. Haemangiosarcomas originating from haemangiomas were also observed. This study also revealed the occurrence of many tumors with anaplasia and pronounced infiltrative features, but which did not metastasize. The elucidation of the cause of this "barrier against metastases" and its relationship with chemical carcinogenesis induced by the ptaquiloside, the active principle of bracken fern (Pteridium aquilinum, could be of interest to future research on the control ofneoplasia in man and animals.Com o objetivo de descrever alterações neoplásicas e não-neoplásicas ainda não relatadas e, paralelamente, reclassificá-las de acordo com nomenclatura mais completa e atual utilizada em medicina humana, foram estudadas, histologicamente, lesões da bexiga de 59 bovinos com Hematúria Enzoótica (HEB, oriundos dos Estados do Rio de Janeiro, São Paulo, Minas Gerais, Espírito Santo, Rio Grande do Sul, Santa Catarina, Paraná e Amazonas.Verificou-se, em termos qualitativos, quase uma perfeita identidade com as lesões de bexiga observadas em seres humanos. Comparações mais exatas com relação à freqüência dessas alterações ficaram prejudicadas, dadas a ocorrência de duas ou mais neoplasias em um mesmo animal e as diferenças da metodologia empregada ou do conceito de classificação. Coexistência entre neoplasias diversas, epiteliais e/ou mesenquimais, foi vista com freqüência. Neoplasias ou diferenciações raras, ainda não descritas na bexiga de bovinos, como carcinoma trabecular com diferenciação em células de Paneth, adenoma e adenocarcinoma mesonefróides, carcinoma "signet ring" (anel de sinete, carcinoma plasmocitóide, carcinoma de células cromófobas e carcinoma transicional tipo ninhado foram observadas na bexiga de alguns animais com HEB. Foram verificados hemangiossarcomas proliferando a partir de hemangiomas.O estudo revelou, ainda, a ocorrência de diversos tumores com anaplasia e carácter infiltrativo acentuados, incapazes, porém, de metastizarem. O esclarecimento da(s causa(s dessa "barreira à metástase" e suas relações com a carcinogênese química induzida pelo ptaquilosídeo, o princípio ativo de Pteridium aquilinum, talvez possa ser de interesse em futuros estudos que visem combater o câncer no homem e nos animais.

  18. Evaluación urodinámica con doxazocina en pacientes con hiperplasia prostática benigna (HPB. Hospital Pablo Tobón Uribe (HPTU de 1998-1999

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    Juan Aristizábal

    2001-04-01

    Full Text Available

    Tradicionalmente la HPB ha sido tratada quirúrgicamente, pero a
    partir de los años 80 ha aparecido una gran variedad de modalidades
    terapéuticas diferentes a la cirugía, basadas en medicamentos orales que disminuyen el tamaño de la próstata y/o los síntomas que esto genera.
    Se propone estudiar con todos los parámetros urodinámicos, la respuesta de los pacientes con HPB tratados con Doxazocina para evaluar su efecto en las curvas Flujo-Presión.

     

     

  19. Treatment of benign brain lesions True Beam radiosurgery in the first year of experience; Tratamiento de lesiones cerebrales benignas con radiocirugia en el True-Beam: Primer ano de experiencia

    Energy Technology Data Exchange (ETDEWEB)

    Lliso, F.; Carmona, V.; Gimeno, J.; Candela, C.; Bautista, J. A.; Perez-Calatayud, J.

    2015-07-01

    The purpose of the work is analyse the first year of experience in the treatment of injury brain benign with Rapid Arc in the patients treated in a throttle True Beam STX with radiosurgery who achieved an adequate level of efficiency and accuracy. (Author)

  20. Comparação dos diagnósticos histológico e molecular do Helicobacter pylori em lesões benignas e adenocarcinomas gástricos

    OpenAIRE

    César, Ana Cristina Gobbo; Cury, Patrícia Maluf; Payão, Spencer Luiz Marques; Liberatore, Paula Rahal; Silva, Ana Elizabete

    2005-01-01

    Helicobacter pylori colonization is associated with chronic gastritis, peptic ulcers, intestinal metaplasia, adenocarcinoma and lymphoma of the stomach. The objective of this study was to compare the results of the routinely used histology with molecular diagnosis for the detection of H. pylori. Eighty samples from gastric lesions (chronic gastritis, atrophic gastritis, gastric ulcer, and intestinal metaplasia), 18 gastric adenocarcinoma and 10 normal mucosa H. pylori-negative (control) sampl...

  1. Tratamiento de la displasia fibrosa asociada a hemofilia C: a propósito de un caso Treatment for fibrous dysplasia when associated with hemophilia C: A case report

    Directory of Open Access Journals (Sweden)

    T. Creo Martínez

    2007-12-01

    Full Text Available La displasia fibrosa es una enfermedad ósea benigna que cambia el tejido óseo normal por una proliferación de tejido conectivo. Se piensa que la alteración del gen Gsalfa es la principal razón de la enfermedad. La hemofilia C es una enfermedad sanguínea, hereditaria rara, que provoca hemorragias en pacientes afectos. Es autonómica recesiva, por lo que hombres y mujeres pueden estar afectos. Paciente de 13 años que desarrolla una displasia fibrosa en maxilar superior derecho que empieza con dolor durante la masticación de alimentos duros. Presenta abombamiento de vestíbulo y enrojecimiento de paladar derecho. Presenta un déficit discreto de factor XI (heterocigoto. Por ello, necesita una preparación especial antes de extirpar la lesión debido a su déficit. Se ha descubierto que la razón de la displasia fibrosa es la mutación del gen Gsalfa (GNAS1 que está en el cromosoma 20q. La causa de la hemofilia C es el déficit del factor XI debido a una mutación del gen FXI en el cromosoma 4. Quizás estas dos raras enfermedades tengan una relación, porque ambas se presentan en el mismo paciente.Fibrous Dysplasia is a benign bone disease that changes normal bone tissue for a proliferation of connective fibrous tissue. It is thought that an alteration of the Gsalpha gene is the main cause of the disease. Hemophilia C is a rare inherited blood disease leading to abnormal hemorrhages in affected patients. They have a factor XI deficiency. It is the least frequent of all hemophilias. It is a recessive autosomal disease, affecting both men and women. A 13 year-old patient developed fibrous dysplasia in right upper maxilla. The patient started with pain on chewing hard food. She had vestibular swelling and reddening of the right side of the palate. She had a discrete factor XI deficiency (heterozygotic. She needed special preparation before the lesion could be removed because of her deficiency. It has been discovered that the mutation of gene

  2. Atrofia muscular proximal neurogenica hereditaria (doença de Wohlfart-Kugelberg-Welander: estudo clinico, eletromiografico e anatomo-patologico de 3 irmãos Hereditary proximal neurogenic muscular atrophy (Wohlfart-Kugelberg-Welander disease: report of three cases

    Directory of Open Access Journals (Sweden)

    Marcos R. G. de Freitas

    1976-03-01

    Full Text Available Os autores relatam os casos de três irmãos com fraqueza e amiotrofia proximal dos membros de início na infância. Os estudos eletromiográficos e de biópsias musculares revelaram alterações do tipo neurogênico de permeio com alterações miogênicas. Fazem consideração sobre esta singular associação, considerando as alterações do tipo miopático como secundárias à denervação de longa duração. O estudo histopatológico medular, em um dos pacientes, revelou degeneração das células motoras das pontas anteriores, constituindo, assim, o 4.° estudo de autópsia da doença de Wohlfart-Kugelberg-Welander, na literatura.The cases of three brothers with proximal weakness and muscles atrophies beginning in childhood are reported. Muscles biopsies and electromyographic studies have shown neurogenic pattern of atrophy and a dystrophy-like picture. It is concluded that this histological and eletromyographic picture can occur in pure partial denervation of long standing. The histopathologic study of the spinal cord of one patient revealed degenerative changes and loss of anterior horn ganglion cells. This is the fourth case of Wohlfar -Kugelberg-Welander disease with postmortem examination.

  3. Benign obstruction of the common hepatic duct (Mirizzi syndrome: diagnosis and operative management Obstrução benigna do ducto hepático comum (síndrome de Mirizzi: diagnóstico e tratamento operatório

    Directory of Open Access Journals (Sweden)

    Jaques Waisberg

    2005-03-01

    Full Text Available BACKGROUND: Mirizzi syndrome is a rare complication of prolonged cholelithiasis, characterized by narrowing of the common hepatic duct due to mechanical compression and/or inflammation due to biliary calculus impacted in the infundibula of the gallbladder or in the cystic duct. OBJECTIVES: To describe a series of eight consecutive patients with Mirizzi syndrome, at a single institution, submitted to surgical treatment and to comment on their aspects with emphasis on the diagnosis and treatment. METHODS: Four women and four men, with a mean age of 61.6 years (42 to 82 years, presenting Mirizzi syndrome were operated between 1997 and 2003. The following items were evaluated: clinical presentation, laboratory results, preoperative evaluation, operative findings, presence of choledocholithiasis, type of Mirizzi syndrome according to the classification by Csendes, choice of operative procedures, and complications. RESULTS: The most frequent symptoms were abdominal pain (87.5% and jaundice (87.5%. All the patients presented altered hepatic function tests. The diagnosis of Mirizzi syndrome was intra-operative in seven (87.5% patients, and preoperative in one (12.5%. Cholecystocholedochal fistula associated with choledocholithiasis was observed in three (37.5% cases. Mirizzi syndrome was classified as Csendes type I in five (62.5% patients, type II in one (12.5%, type III in one (12,5% and type IV in another (12.5%. Cholecystectomy, as an isolated surgical procedure, was performed in four (50.0% patients. One (12.5% patient was submitted to partial cholecystectomy and closure of the fistulous orifice with the central part of the infundibula. Two (25.0% patients were submitted to cholecystectomy and side-to-side choledochoduodenostomy and another (12.5% to side-to-side choledochoduodenostomy remaining the gallbladder in situ. Seven (87.5% patients had an uneventful recovery and were discharged in good conditions. One (12.5% patient presented a postoperative sepsis due to a sub-hepatic abscess, and was reoperated. There was no operative mortality. CONCLUSION: The preoperative diagnosis of Mirizzi syndrome is difficult and an awarded suspicion is necessary to avoid lesions of the biliary tree. The problem may only become evident during the operation due to firm adherences around Calot's triangle. The success of the treatment is related to a precocious recognition of the condition, even at the time of surgery, and adapting the management considering to the individual characteristics of each case.RACIONAL: A síndrome de Mirizzi, é complicação rara da colelitíase de longa duração, caracterizada pelo estreitamento do ducto hepático comum devido a mecanismo de compressão e/ou inflamação por cálculos biliares impactados no infundíbulo da vesícula biliar ou no ducto cístico. OBJETIVO: Descrever série de oito enfermos consecutivos com síndrome de Mirizzi de uma única instituição, submetidos ao tratamento cirúrgico e comentar seus aspectos com ênfase no diagnóstico e tratamento. MÉTODO: Quatro mulheres e quatro homens, com média de idade de 61,6 anos (42 a 82 anos, foram operados com síndrome de Mirizzi entre 1997 e 2003. Avaliaram-se a apresentação clínica, os resultados dos exames laboratoriais e de imagem, os achados operatórios, a presença de coledocolitíase, o tipo de síndrome de Mirizzi de acordo com a classificação de Csendes, a escolha do procedimento operatório e as complicações pós-operatórias. RESULTADOS: Os sintomas mais freqüentes foram dor abdominal (87,5% e icterícia (87,5%. Todos os doentes apresentaram exames de função hepática alterados. O diagnóstico da síndrome de Mirizzi foi intra-operatório em sete (87,5% doentes, e pré-operatório em um (12,5%. Observou-se fístula colecistocoledociana associada à coledocolitíase em três (37,5% casos. A síndrome de Mirizzi foi classificada como tipo I em cinco (71,4% doentes, tipo II em um (14,3%, tipo III em um (12,5%, e tipo IV em outro (12,5%. A colecistectomia, como procedimento cirúrgico isolado, foi realizada em quatro (50,0% doentes. Um (12,5% enfermo foi submetido a colecistectomia parcial e fechamento do orifício fistuloso com a região central do infundíbulo. Dois (25,0% enfermos foram submetidos a colecistectomia e anastomose coledocoduodenal látero-lateral e outro (12,5% a anastomose coledocoduodenal látero-lateral, deixando-se a vesícula biliar in situ. Sete (87,5% doentes evoluíram sem complicações pós-operatórias e obtiveram alta hospitalar em boas condições. Um (12,5% enfermo apresentou, no pós-operatório, sepse por abscesso sub-hepático, sendo re-operado. Não houve mortalidade operatória. CONCLUSÕES: O diagnóstico pré-operatório da síndrome de Mirizzi é difícil e é necessário elevado índice de suspeita para evitar lesões da árvore biliar. O problema pode se tornar evidente apenas no momento da operação na forma de aderências firmes ao redor do triângulo de Calot. O sucesso do tratamento está relacionado ao reconhecimento precoce da condição, mesmo no intra-operatório, e na individualização da conduta, de acordo com as características de cada caso.

  4. Caracterización clínica y genética de familias españolas con retinosis pigmentaria autosómica dominante mediante secuenciación masiva y otras técnicas de diagnóstico molecular

    OpenAIRE

    Fernández San José, Patricia

    2018-01-01

    Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Bioquímica. Fecha de lectura: 18-09-2017 Las distrofias hereditarias de retina (DR), con una prevalencia de 1: 3000, son la principal causa de discapacidad visual registrada en el mundo desarrollado. Este grupo de patologías están causadas por la degeneración de los fotorreceptores de la retina. Las DR representan una de las enfermedades hereditarias más heterogéneas, tanto clí...

  5. Urinary catheters

    Science.gov (United States)

    Catheter - urine; Foley catheter; Indwelling catheter; Suprapubic catheters ... stones Blood infections ( septicemia ) Blood in the urine (hematuria) Kidney damage (usually only with long-term, indwelling ...

  6. Early changes of the anemia phenomenon in male 100-km ultramarathoners

    Directory of Open Access Journals (Sweden)

    Yu-Hui Chiu

    2015-02-01

    Conclusion: Running a 100-km ultramarathon will induce substantial sports anemia, and oxidative stress response, hemolysis, hematuria, and gastrointestinal bleeding are typical factors that contribute to its onset.

  7. Recusa na marcha em criança com varicela

    Directory of Open Access Journals (Sweden)

    Catarina Faria

    2016-06-01

    Full Text Available A varicela, é uma patologia comum na infância, habitualmente benigna e auto-limitada. Embora pouco frequentes, podem ocorrer complicações, nomeadamente a nível neurológico, cutâneo, pulmonar e, mais raramente, muscoloesquelético.Descrevemos um caso de osteomielite a streptococcus pyogenes (s.pyogenes em contexto de varicela, numa criança previamente saudável.Pretendemos chamar a atenção para a possível ocorrência de complicações graves nesta patologia frequente e globalmente benigna.

  8. La mamografía y la ecografía en el estudio de la patología mamaria en el varón

    OpenAIRE

    Muñoz Carrasco, Rafaela

    2011-01-01

    Objetivo: Valorar las variables clínicas que pueden ser útiles para diferenciar patología mamaria benigna de maligna y analizar la contribución de la mamografía y la ecografía en la evaluación de la mama masculina. Material y métodos: Estudio retrospectivo que incluye todos los pacientes varones que tuvieran realizada mamografía o ecografía entre 1993 y 2006 en nuestro hospital. Se comparan las características clínicas de los pacientes con patología mamaria benigna y maligna. Los hallazgos...

  9. [Intravesical active prostate bleeding diagnosed in B-mode ultrasound].

    Science.gov (United States)

    Kirchgesner, T; Danse, E; Tombal, B

    2013-09-01

    Hematuria is one of the most frequent minor complications after prostatic biopsy. We would like to report the case of a 68-year-old patient with massive hematuria after prostatic biopsy and intravesical active prostate bleeding diagnosed in B-mode ultrasonography. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  10. The Effects of Instrumentation on Urine Cytology and CK-20 Analysis for the Detection of Bladder Cancer

    NARCIS (Netherlands)

    Wegelin, Olivier; Bartels, Diny W M; Tromp, Ellen; Kuypers, Karel C.; Van Melick, Harm H E

    2015-01-01

    Objective To evaluate the effects of cystoscopy on urine cytology and additional cytokeratin-20 (CK-20) staining in patients presenting with gross hematuria. Patients and Methods For 83 patients presenting with gross hematuria, spontaneous and instrumented paired urine samples were analyzed. Three

  11. Control of persistent vesical bleeding due to radiation cytitis by intravesical application of 15(s) 15-methyl prostaglandin F2-alpha

    International Nuclear Information System (INIS)

    Hemal, A.K.; Praveen, B.V.; Sankaranarayanan, A.; Vaidyanathan, S.

    1989-01-01

    A 45 year old female who received radiotherapy for stage II-B uterine cervical cancer four and half years ago, presented with persistent hematuria due to radiation cystitis. 15(S) 15-methyl prostaglandin F 2 -alpha (1 mg in 100 ml of normal saline) was instilled into the bladder daily for two days. The severity of bleeding decreased considerably. However, significant hematuria recurred 19 days later which continued despite bladder irrigation with normal saline, 1 mg of 15(S) 15-Me PGF 2 alpha mixed with hydroxyethyl cellulose gel to a volume of 10 ml was then instilled into the urinary bladder daily for three days and macroscopic hematuria ceased. Urinary frequency and urgency were the side effects which lasted for ten days. There has been no recurrence of macroscopic hematuria during the five months followup. In conclusion, 15(S) 15-Me PGF 2 - alpha may be administered intravesically to control moderate hematuria due to radiation cystitis. (author). 5 refs

  12. Implicaciones anestésicas de un caso de leucodistrofia metacromática

    OpenAIRE

    Gupta, Arun Kumar; Mahajan, Charu; Mehta, Anjali; Dhulkhed, Vithal K

    2010-01-01

    La leucodistrofia metacromática es una enfermedad progresiva hereditaria y neurodegenerativa. Un paciente que sufre de esta enfermedad representa múltiples problemas anestésicos. Hemos anestesiado exitosamente una niña que sufre de leucodistrofia metacromática con anestesia general. Metachromatic leukodystrophy is a progressive, inherited and neurodegenerative disease. A patient suffering from this disease poses a lot of anaesthetic problems. We have successfully anaesthetized a female chi...

  13. Plan integral de enfermería para la atención domiciliaria de pacientes con enfermedad neuromuscular e insuficiencia respiratoria

    OpenAIRE

    Terán Pérez, Jimena

    2013-01-01

    Las enfermedades neuromuscualres son enfermedades neurológicas, de naturaleza progresiva, normalmente hereditarias cuya principal característica clínica es la debilidad muscular. Dentro de las enfermedades que causan problemas respiratorios, existen una gran variedad de enfermedades neuromusculares que comprometen la función respiratoria, las cuales pueden dividirse en enfermedades neuromusculares neuropaticas y miopáticas, además de poder clasificarlas según la evolución. Las ENM pueden c...

  14. Hemorragia digestiva alta secundária a hamartoma de glândulas de Brunner: relato de caso e revisão da literatura = Upper gastrintestinal bleeding due to Brunner’s gland hamartoma: case report and literature review

    Directory of Open Access Journals (Sweden)

    Lul, Rodrigo Mayer

    2013-01-01

    Conclusões: Apesar do hamartoma de glândulas de Brunner ser uma lesão benigna e rara, de crescimento indolente e comumente assintomática, pode provocar quadros graves como o descrito neste relato, devendo ser sempre lembrado como diagnóstico diferencial em casos de hemorragia digestiva alta

  15. Un caso de herida del corazón

    Directory of Open Access Journals (Sweden)

    Miguel Antonio Casas

    1940-01-01

    fríos y fiebres (tercia benigna, para lo cual se trató convenientemente, además presentó un esguince de la articulación del carpo con deslizamiento de una bolsa sinovial para lo cual se le aplicó una banda compresora y se le suprimieron los ejercicios fuertes.

  16. Genotipificación de los polimorfismos -511, -31 y +3954 del gen de la interleucina-1β humana en una población colombiana con cuadro de dispepsia

    Directory of Open Access Journals (Sweden)

    María Teresa Arango

    2010-08-01

    Conclusión. No se encontraron diferencias significativas en los genotipos de los individuos infectados y los no infectados por H. pylori, a excepción del genotipo CC en la región polimórfica -31, el cual se encontró con mayor frecuencia en los pacientes con enfermedades benignas.

  17. Condroma en tejidos blandos, dedo de la mano. Presentación de un caso.

    Directory of Open Access Journals (Sweden)

    Ángel D. Cruz Coca

    2014-09-01

    El sitio, el aspecto radiológico y la ausencia de cualquier conexión de este tumor a la subyacente articulación, huesos y tendones es extremadamente rara. A pesar de las preocupaciones de una neoplasia agresiva, la lesión era benigna en la histología.

  18. Papiloma vírico

    OpenAIRE

    Albiol Ferrer, Josep Maria; Giralt de Veciana, Enrique; Novel Martí, Virginia; Ogalla, José Manuel; Zalacain, Antonio

    1990-01-01

    Tumoración benigna y circunscrita de la piel; causada por el 'Papova virus'. constituido por tejido fibroso conjuntivo de sostén que contiene a las papilas y rodeadas de tejido epitelial que lo encapsula. (anida en el tejido papilar)

  19. Displasias del seno

    Directory of Open Access Journals (Sweden)

    Ernesto Andrade Valderrama

    1971-04-01

    Full Text Available En general, las Displasias no se presentan antes de la iniciación del estímulo Gonadal y tienden a desaparecer con el climaterio. Se definen entonces como las afecciones benignas del Seno, de origen endocrino.

  20. Baltisaksa naiste esimesed luulekogud ja -põimikud / Kairit Kaur

    Index Scriptorium Estoniae

    Kaur, Kairit

    2011-01-01

    Lähemalt vaadeldakse kolme luulekogu: Benigna Gottliebe "Suurt ristikandjat" (1777), Elisa von der Recke "Suursuguse Kuramaa daami vaimulikke laule" (1780) ning "preili von Grafina" tuntud luuletajanna värsipõimikut ajakirjas "Nordische Miscellaneen" - "Ühe kõrgemast seisusest liivimaalanna mitmesuguseid luuletusi ja laule" (1781)

  1. Inflammatory Myofibroblastic Tumor of the Bladder: 2 Rare Cases Managed with Laparoscopic Partial Cystectomy

    Directory of Open Access Journals (Sweden)

    Sofia Santos Lopes

    2016-01-01

    Full Text Available Two cases of inflammatory myofibroblastic tumor (IMT of the bladder are reported here. Both patients were male and presented with macroscopic hematuria; in the first case terminal hematuria was associated with irritative voiding symptoms. The second case was a smoker with hematuria unresponsive to medical treatment and anemia. Clinical presentation, pathological features, treatment, and prognosis are discussed. Due to rarity of this pathological condition, there are no guidelines concerning treatment and follow-up. We present our follow-up scheme and highlight the use of laparoscopic partial cystectomy as a successful treatment approach.

  2. Renal Bleeding Due to Extramedullary Hematopoiesis in a Patient With Chronic Myelogenous Leukemia

    Directory of Open Access Journals (Sweden)

    Stephanie Zettner

    2014-11-01

    Full Text Available Chronic myelogenous leukemia (CML is a myeloproliferative disorder that normally presents in middle-aged adults. Renal infiltration and extramedullary hematopoiesis in renal tissue has been rarely reported. This case report presents a patient with CML and renal insufficiency who developed gross hematuria. Efforts at controlling the hematuria led to a cascade of events propelled by the underlying disorder that ultimately led to a radical nephrectomy, multiorgan failure, and prolonged hospitalization. We suggest that management of gross hematuria in clinically stable patients with CML, suspected of having extramedullary hematopoiesis, should prioritize treatment of the myeloproliferative disorder over efforts to control bleeding.

  3. Renal Bleeding Due to Extramedullary Hematopoiesis in a Patient With Chronic Myelogenous Leukemia.

    Science.gov (United States)

    Zettner, Stephanie; Mistry, Sandeep G

    2014-11-01

    Chronic myelogenous leukemia (CML) is a myeloproliferative disorder that normally presents in middle-aged adults. Renal infiltration and extramedullary hematopoiesis in renal tissue has been rarely reported. This case report presents a patient with CML and renal insufficiency who developed gross hematuria. Efforts at controlling the hematuria led to a cascade of events propelled by the underlying disorder that ultimately led to a radical nephrectomy, multiorgan failure, and prolonged hospitalization. We suggest that management of gross hematuria in clinically stable patients with CML, suspected of having extramedullary hematopoiesis, should prioritize treatment of the myeloproliferative disorder over efforts to control bleeding.

  4. Severe acute post-streptococcal glomerulonephritis in an infant

    Directory of Open Access Journals (Sweden)

    Jameela A Kari

    2013-01-01

    Full Text Available Acute post-streptococcal glomerulonephritis (APSGN is very rare below the age of two years. We report a 14-month-old girl who presented with frank hematuria and nephrotic syndrome following group A streptococcal pharyngitis (GAS, which was confirmed by laboratory investigations. The patient underwent a renal biopsy to confirm the diagnosis and was treated with prednisolone. The proteinuria and hematuria resolved completely in eight weeks. Our case demonstrates that APSGN should be considered in evaluating hematuria and nephrotic syndrome in infants and children below two years of age.

  5. Disease: H00579 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available to the missense mutations in the COL4A1 in basement membranes. The renal manifestations include hematuria an...erited diseases of the glomerular basement membrane. ... JOURNAL ... Nat Clin Pract N

  6. Renal cell carcinoma as a cause of iron deficiency anemia

    African Journals Online (AJOL)

    Amar A. Dowd

    derived from the various parts of the nephron (epithelium or renal tubules) and possessing ... [3] is hematuria, flank pain, and an abdominal mass, similar to bloat- ... mass in the right kidney implicating its anterior aspect, measuring 62 × 48 mm.

  7. Learning curve of MRI-based planning for high-dose-rate brachytherapy for prostate cancer

    DEFF Research Database (Denmark)

    Buus, Simon; Rylander, Susanne; Hokland, Steffen

    2016-01-01

    and increased significantly from average 8.3 to 9.0 Gy (p 95% of procedures, respectively, and did not change significantly. Hematuria occurred in (95%), hematoma (80%), moderate to strong pain (35%), and urinary retention (5...

  8. Hantaviruses: an emerging public health threat in India? A review

    Indian Academy of Sciences (India)

    PRAKASH KUMAR

    However, later studies have shown that 7.1% of DOBV positive acute phase samples and 12.5% .... Urine analysis shows proteinuria, hematuria and pyuria. Significant elevations of ..... and proper storage of food should be practiced. There are.

  9. Microhematuria Associated with a Special Operations Craft Mission

    National Research Council Canada - National Science Library

    Hodgdon, James A; Walsh, Brandon J; Hackney, Anthony C

    2004-01-01

    .... In order to determine whether or not a similar hematuria accompanies mechanical shock exposure associated with small boat operations in the open ocean, urinary variables were measured in two boat crews (total N = 12...

  10. Challenges in the Management of Bleeding Disorders in Nigeria

    African Journals Online (AJOL)

    2018-04-04

    Apr 4, 2018 ... (which could be immune mediated, drug induced, or due to hematological ... or VWD to hemarthroses, hematuria, intramuscular, intracerebral, and ... adequate and skilled workforce, and service delivery in general.[10] Reding ...

  11. ISSN 2073 East Cent. Afr. j. surg.

    African Journals Online (AJOL)

    DELL

    2009-02-27

    Feb 27, 2009 ... Bladder Tumours at Tikur Anbessa Hospital in Ethiopia. ... The most common presenting symptoms were hematuria in 89(91.8%). cystoscopy ..... West DA, Cummings JM, Longo WE, et al; Role of chronic catheterization in the.

  12. Genetics Home Reference: Alport syndrome

    Science.gov (United States)

    ... A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons. ... is characterized by hematuria. Alport syndrome has autosomal dominant inheritance in about 5 percent of cases. People ...

  13. Prevalence and associations of symptomatic renal papillary necrosis ...

    African Journals Online (AJOL)

    2015-11-12

    Nov 12, 2015 ... Diagnosis was based on microscopic hematuria and positive ultrasound findings. Their steady ... until recently the most widely accepted first account was documented by ... papillary necrosis in sickle cell anemia patients in.

  14. Efficacy of voided urinary cytology and ultrasonography compared to cystoscopy in the detection of urinary bladder cancer

    Directory of Open Access Journals (Sweden)

    N. Kumar

    2017-09-01

    Conclusions: Voided urinary cytology can be omitted as a screening test. Ultrasonography can be recommended as the initial imaging investigation for detection of bladder carcinoma in patients presenting with hematuria and for follow up of bladder carcinoma patients.

  15. Epidemiological characteristics of childhood urolithiasis in Morocco ...

    African Journals Online (AJOL)

    Objectives: Due to the increase observed in the incidence of pediatric urolithiasis in the ... pain (28%), nephritic colic (22%), hematuria (22%) and urinary tract infection (13%). Stones were located in the upper urinary tract in 62.5% of cases.

  16. Renal Bleeding Due to Extramedullary Hematopoiesis in a Patient With Chronic Myelogenous Leukemia

    OpenAIRE

    Stephanie Zettner; Sandeep G. Mistry

    2014-01-01

    Chronic myelogenous leukemia (CML) is a myeloproliferative disorder that normally presents in middle-aged adults. Renal infiltration and extramedullary hematopoiesis in renal tissue has been rarely reported. This case report presents a patient with CML and renal insufficiency who developed gross hematuria. Efforts at controlling the hematuria led to a cascade of events propelled by the underlying disorder that ultimately led to a radical nephrectomy, multiorgan failure, and prolonged hospital...

  17. Hemangioma of the prostate--an unusual cause of lower urinary tract symptoms

    DEFF Research Database (Denmark)

    Serizawa, Reza R; Nørgaard, Nis; Horn, Thomas

    2011-01-01

    Hemangioma of the prostate gland is extremely rare and only a few cases have been reported. There have been several cases of hemangioma of posterior urethra, urinary bladder and periprostatic plexus in the literature, all presenting with hematuria or hematospermia. Diagnosis of prostatic hemangioma...... is difficult due to its rarity and unspecific symptoms such as hematuria, hematospermia or lower urinary tract symptoms. It cannot be detected by conventional examinations such as cystoscopy or standard rectal ultrasonography....

  18. KEJADIAN KOLONI JAMUR PADA PENDERITA OTORE DENGAN BERBAGAI PENYEBAB DI POLIKLINIK THT RUMAH SAKIT PENDIDIKAN UNHAS

    Directory of Open Access Journals (Sweden)

    Sedjawidada R

    2014-09-01

    Full Text Available Telah dilakukan penelitian survey dengan pendekatan deskriptif tentang Kejadian Koloni Jamur pada Penderita Otore dengan Berbagai Penyebab di Poliklinik THT Rumah Sakit Pendidikan Unhas. Sampel yang diteliti adalah eksudat yang diambil dari liang telinga luar setiap telinga yang menderita Otitis eksterna superfisialis basah, Otitis media supuratif akut perforasi, Otitis media supuratif kronik benigna aktif. Dari total sampel sejumlah 103 yang dipilih secara consecutive sampling didapatkan adanya koloni jamur pada otitis eksterna superfisialis basah sebesar 57,8% dengan jenis jamur Aspergillus niger 17,9%, Candida albicans 13,3% dan Aspergillus fumigatus 8,9%. Koloni jamur pada OMSA perforasi sebesar 44,4% dengan jenis jamur Aspergillus fumigatus 11,1%, Candida albicans 11,1% dan Aspergillus niger 5,6%. Koloni jamur pada OMSK benigna aktif sebesar 25% dengan jenis jamur Apergillus fumigatus 17,5%, Aspergillus niger 2,5% dan Candida albicans 2,5%.[MEDICINA 2009;40:21-6].

  19. Lesiones papilomatosas en genitales externos de delfines Tursiops truncatus

    OpenAIRE

    Ancheta, O.; Cruz, D.; Guevara, C.; Rodríguez, S.; Chamizo, E.; Valdés, T.; Harvey, Y.; Gutiérrez, N.; González, L.

    2009-01-01

    La papilomatosis es una entidad tumoral generalmente benigna que ataca la piel y mucosas de diferentes zonas del cuerpo. Esta enfermedad puede limitar la reproducción en los cetáceos y una de sus causas puede ser la infección por papilomavirus. La observación de pequeñas verrugas en la piel o mucosas de estos animales hace inferir la presencia de lesiones papilomatosas.

  20. Ruptura do septo interventricular após trauma torácico fechado Ventricular septal rupture following blunt chest trauma

    Directory of Open Access Journals (Sweden)

    Ronaldo Peixoto de Mello

    2006-12-01

    Full Text Available Relatamos a seguir um caso de ruptura do septo interventricular após trauma torácico automobilístico com evolução relativamente benigna a despeito da extensão da lesão anatômica.We report a case of ventricular septal rupture following chest trauma resulting from a car accident. The outcome was relatively favorable despite the extension of the anatomic lesion.

  1. Oral and maxillofacial biopsied lesions in Brazilian pediatric patients: a 16-year retrospective study = Biópsias de lesões orais e maxilo-faciais em pacientes pediátricos brasileiros: estudo retrospectivo de 16 anos

    Directory of Open Access Journals (Sweden)

    Mouchrek, Monique Maria Melo

    2011-01-01

    Conclusão: Este estudo mostra uma tendência semelhante à relatada em estudos anteriores sobre as lesões mais freqüentes na região oral e maxilo-facial na população pediátrica. A maioria das lesões detectadas foram benignas, enquanto as malignas foram diagnosticadas em um número muito reduzido de pacientes

  2. Leucoedema: una revisión de la literatura

    OpenAIRE

    Viñals Iglesias, Helena

    1999-01-01

    El leucoedema es una entidad de naturaleza benigna, que clinicamente se describe como un blanqueamiento difuso y opalino de la mucosa oral que le confiere un aspecto aterciopelado, generalmente bilateral, simétrico y de carácter crónico. Es más frecuente en negros americanos, aunque la prevalencia descrita en cada estudio es controvertida, al igual que su patogenia. Histologicamente se caracteriza por una hiperparaqueratosis, una acantosis con hiperplasia epitelial, espongiosis, edema intrace...

  3. Carcinoma basocelular en nariz de paciente interno en un centro penitenciario

    Directory of Open Access Journals (Sweden)

    Francisco Javier Suárez Guzmán

    2016-01-01

    Discusión. Existen varias alternativas terapéuticas, siendo la cirugía la más efectiva. El interés para el médico de atención primaria reside en saber hacer el diagnóstico diferencial de otras lesiones benignas, realizar el seguimiento y estar al día de las alternativas terapéuticas.

  4. Análisis de una nueva variante fenotípica de distrofia del estroma corneal

    OpenAIRE

    Varela Conde, Yago

    2016-01-01

    Las distrofias corneales son un conjunto de enfermedades hereditarias de la córnea con base genética demostrable y sin afectación sistémica. Su nomenclatura y clasificación han sido revisadas recientemente, prescindiendo de ciertas patologías y agrupando las distrofias en nuevas categorías. Se ha hallado una variante fenotípica atípica con afectación del estroma corneal, por lo que sólo se han revisado las distrofias corneales localizadas a ese nivel (epiteliales-estromales y estromales). ...

  5. Detección de alteraciones numéricas en el gen dys y su asociación con rasgos clínicos Numeric alterations in the dys gene and their association with clinical features

    OpenAIRE

    Alejandra Mampel; María Inés Echeverría; Ana Lía Vargas; María Roque

    2011-01-01

    La distrofia muscular de Duchenne/Becker (DMD/B) es una miopatía hereditaria grave y progresiva. Se relaciona con alteraciones en el gen DYS, ubicado en el cromosoma X, que codifica para la proteína distrofina. Distintas manifestaciones pueden observarse según el impacto de la alteración genética sobre la proteína. Los registros internacionales de mutaciones refieren una elevada frecuencia (65-70%) de deleciones/duplicaciones de uno o más exones del gen DYS. En este trabajo presentamos el est...

  6. Rehabilitación oral de un paciente pediátrico con síndrome de Smith-Lemli-Opitz bajo anestesia general ambulatoria

    OpenAIRE

    Dorado Castro, Magda; Universidad Autónoma de Baja California, Tijuana, México; Fregoso Guevara, Carlos Alberto; Universidad Autónoma de Baja California, Tijuana, México; Sánchez Rubio Carrillo, Ricardo Manuel; Universidad Autónoma de Baja California, Mexicali, México; Zamudio Gómez, Miguel Alberto; Universidad Autónoma de Baja California, Tijuana, México

    2011-01-01

    El síndrome de Smith-Lemli-Opitz es una rara enfermedad hereditaria de transmisión au¬tosómica recesiva. Se caracteriza por presentar hipocolesterolemia como consecuencia de una mutación del gen 7-deshidrocolesterol reductasa (7DHCR), lo que produce retraso mental, retardo en el crecimiento, microcefalia, micrognatismo y otras anomalías neuroló¬gicas sistémicas y físicas. Se presenta el caso de un paciente de tres años y nueve meses afectado por este síndrome, quien acudió a la clínica de odo...

  7. Terapia génica de la enfermedad de Stargardt

    OpenAIRE

    Martín Nieto, José

    2015-01-01

    El gen humano ABCA4 (=ABCR) se caracterizó en 1997 como el principal causante de la enfermedad de Stargardt, una distrofia macular hereditaria generalmente autosómica recesiva. Poco tiempo después se encontraron otras enfermedades asociadas a mutaciones en este gen, como son distrofia de conos y bastones, determinados casos de retinosis pigmentaria y un aumento de la susceptibilidad a la degeneración macular asociada a la edad. No existen tratamientos curativos para ninguna de estas distrofia...

  8. Tratamiento fisioterápico en la distrofia muscular de Duchenne

    OpenAIRE

    Burgos González, Sara

    2014-01-01

    la Distrofia Muscular de Duchenne es una enfermedad neuromuscular hereditaria de carácter recesivo ligada al cromosoma X. Afecta aproximadamente a 1 de cada 3500 niños varones nacidos vivos. Se caracteriza por cursar con una debilidad progresiva como resultado de una degeneración de los músculos, iniciando en piernas y pelvis y posteriormente abarcando todo el cuerpo. Este trastorno se debe a una mutación que es culpable de la ausencia de una proteína muscular, la distrofina...

  9. Alteraciones en la degradación intracelular de proteínas y en la endocitosis en las lipofuscinosis ceroideas neuronales infantil tardía y juvenil

    OpenAIRE

    Vidal Donet, José Manuel

    2014-01-01

    Las lipofuscinosis ceroideas neuronales son un grupo heterogéneo de enfermedades neurodegenerativas hereditarias graves que tienen su inicio en la infancia y que se engloban dentro de las enfermedades de almacenamiento lisosomal. Las características clínicas de estas patologías son una disminución de la capacidad mental acompañada de alteraciones motoras, epilepsia y pérdida de visión. Histológicamente las células muestran una acumulación de material autofluorescente (lipofuscina) en el inte...

  10. Ataxia crónica en pediatría

    Directory of Open Access Journals (Sweden)

    Ricardo Erazo Torricelli

    2013-09-01

    Full Text Available Las ataxias crónicas constituyen un grupo heterogéneo de enfermedades, que afectan al niño a diferentes edades. Así las formas congénitas, generalmente no progresivas, se observan desde los primeros meses de vida y se expresan por hipotonía y retraso motor, mucho antes de que la ataxia se haga evidente. La resonancia magnética cerebral puede ser diagnóstica en algunos cuadros, como ocurre con el síndrome de Joubert. El grupo de ataxias hereditarias progresivas, en constante expansión, suelen comenzar después del período del lactante. Los signos clínicos destacables son la apraxia ocular y la inestabilidad de la marcha que pueden asociarse a telangiectasias oculocutáneas (ataxia-telangiectasia o a neuropatía sensitiva (ataxia de Friedreich. En esta revisión se describen en forma sucinta las ataxias congénitas y en forma más detallada las causas principales de ataxias hereditarias progresivas autosómicas recesivas, autosómicas dominantes y mitocondriales. Se destaca la importancia del estudio genético, que es la clave para lograr el diagnóstico en la mayoría de estas enfermedades. Aunque aún no hay tratamiento para la mayoría de las ataxias hereditarias progresivas, algunas sí lo tienen, como la enfermedad de Refsum, déficit de vitamina E, déficit de Coenzima Q10, por lo cual el diagnóstico en estos casos es aún más relevante. En la actualidad, el diagnóstico de los cuadros de ataxia hereditaria del niño aún no tratable es fundamental para lograr un manejo adecuado, determinar un pronóstico preciso y dar a la familia un consejo genético oportuno.

  11. Usher syndrome : molecular analysis of USH2 genes and development of a next-generation sequencing platform

    OpenAIRE

    García-García, Gema

    2013-01-01

    El síndrome de Usher (USH) es una enfermedad hereditaria autosómica recesiva, caracterizada por la asociación de hipoacusia neurosensorial, retinosis pigmentaria y, en ocasiones, alteración de la función vestibular. Clínicamente, el USH se puede clasificar en tres tipos (USH1, USH2 y USH3), principalmente en base a la gravedad y progresión de la hipoacusia y presencia o no de disfunción vestibular. El USH es heterogéneo tanto a nivel clínico como genético y, hasta la fecha, se han descrito 11...

  12. Evaluation and improvement of the quality of the discharge prescription in Cystic Fibrosis children hospitalised for intravenous antibiotic therapy

    OpenAIRE

    Chorro Marí, Verónica

    2017-01-01

    1.Antecedentes. La Fibrosis Quística (FQ) es una enfermedad conocida desde la edad media, aunque durante esa época no estaba descrita como tal sino más bien como un hechizo maligno. En 1943, Farber propuso el término mucoviscidosis y este término se sigue utilizando en la actualidad. La FQ es la enfermedad hereditaria autosómica recesiva grave más frecuente en la población blanca, con una incidencia en Europa que oscila entre 1:1.353 en Irlanda y entre 1:25.000 en Finlandia, y una fre...

  13. Pancreatitis, genes y autotrasplante de islotes: actualizaciones y nuevos horizontes

    OpenAIRE

    Rivera Rivera, Edgardo D

    2017-01-01

    La pancreatitis es una inflamación del páncreas que puede progresar de una presentación aguda, a una presentación aguda recurrente y eventualmente a pancreatitis crónica, caracterizada por cambios morfológicos y formación de cicatriz los cuales son irreversibles. La entidad conocida como pancreatitis hereditaria ha sido reconocida en la literatura por años y ciertamente el hallazgo del gen PRSS1 en 1996 marcó el inicio de una era de descubrimientos genéticos asociados a dicha enfermedad. Desd...

  14. Atrofia muscular espinal tipo 1: enfermedad de Werdnig-Hoffmann

    OpenAIRE

    Zárate-Aspiros, Romeo; Rosas-Sumano, Ana Beatriz; Paz-Pacheco, Alberto; Fenton-Navarro, Patricia; Chinas-López, Silvet; López-Ríos, José Antonio

    2013-01-01

    Introducción. Las atrofias musculares espinales de la infancia son enfermedades neuromusculares hereditarias, autosómicas, recesivas, caracterizadas por la degeneración de las neuronas motoras del asta anterior de la médula espinal. La atrofia muscular espinal tipo I (enfermedad de Werdnig-Hoffmann) es la forma más severa. Se inicia in útero o durante los primeros meses de vida. La muerte suele ocurrir antes de los dos años de edad. Caso clínico. Lactante de 6 meses de edad que ingresa al Ser...

  15. Bases celulares y moleculares de la atrofia muscular espinal : papel del factor de supervivencia de las motoneuronas (SMN)

    OpenAIRE

    Castillo Iglesias, María Soledad

    2016-01-01

    La atrofia muscular espinal (SMA) es una enfermedad infantil hereditaria caracterizada por la muerte de las motoneuronas con denervación y atrofia muscular que puede ocasionar la muerte de los pacientes por insuficiencias respiratoria. Su herencia es autosómica recesiva por deleción o mutaciones en el gen “Survival Motor Neuron 1” (SMN1), que codifica la proteína SMN. En el hombre existe un gen homólogo, SMN2, que produce niveles muy bajos de SMN completa y no evita la aparición de la enferme...

  16. ¿QUÉ ES EL ASESORAMIENTO GENÉTICO Y CÓMO REALIZARLO EN ONCOLOGÍA?

    OpenAIRE

    Sra. Sonia Margarit

    2017-01-01

    Es común que individuos sanos y afectados con antecedentes familiares de alguna condición manifiesten ansiedad y requieran información acerca de sus riesgos y los riesgos de sus parientes cercanos. El asesoramiento genético nace de la necesidad de ayudar a los individuos y a las familias con un diagnóstico o con riesgos de una condición genética hereditaria a comprender y adaptarse a las implicancias de los resultados de estudios genéticos, los que pueden determinar un diagnóstico definitivo ...

  17. La genética humana en Costa Rica situación actual y sus perspectivas

    OpenAIRE

    Barrantes Mesén, Ramiro

    1985-01-01

    Artículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 1985 Se analiza la situación de la genética humana en Costa Rica mediante un estudio de la literatura científica publicada entre 1964 y 1984. Se muestra que a partir de 1976 se ha incrementado el número de publicaciones en este campo, destacando las investigaciones sobre hemoglobinas anormales, la estructura genética de varias poblaciones y la caracterización de algunas enfermedades hereditarias. Se co...

  18. Curvas de mutación en el estudio del papel de los diferentes tipos de reparación en el mantenimiento de la información en Drosophila

    Directory of Open Access Journals (Sweden)

    P. Grigoriu De Buendía

    2001-07-01

    Full Text Available La producción de mutaciones que es responsable de enfermedades hereditarias y cáncer ha sidorelacionada con la actuación de los mecanismos postreplicativos de reparación. La síntesistranslesion y la recombinación no homologa han sido postulados como responsables de muta-ciones desde 1975 (Witkin. En el estudio de la síntesis translesión se han hecho avances impor-tantes en varias especies últimamente.

  19. Genes y proteínas asociadas a distroglicanopatías en la retina de mamíferos adultos: función del gen POMT1

    OpenAIRE

    Uribe, Mary Luz

    2016-01-01

    La O-manosilación de proteínas es una modificación postraduccional de gran relevancia en eucariotas. El α−distroglicano (α-DG), componente principal del complejo distrofina-glicoproteína en el músculo y células nerviosas, se encuentra altamente O-manosilado. Existe un grupo de distrofias neuromusculares hereditarias cuya base molecular subyacente es un déficit en la glicosilación del α−DG. Son las llamadas distroglicanopatias (DGPs), las cuales ofrecen a los pacientes una corta esperanza de v...

  20. Caracterización molecular de las formas precoces de distrofia de retina recesivas y esporádicas en población española: amaurosis congénita de Leber y Retinosis pigmentaria de inicio precoz

    OpenAIRE

    Tatu, Sorina Daniela

    2016-01-01

    Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura: 27-01-2016 Esta tesis tiene embargado el acceso al texto completo hasta 27-07-2017 Las distrofias hereditarias de la retina (DR) son un conjunto de trastornos que se producen por una degeneración primaria y progresiva de fotorreceptores. Entre ellas, la amaurosis congénita de Leber (LCA) representa la forma más precoz y severa, ocasionando ...

  1. Seguimiento a largo plazo de un paciente con raquitismo dependiente de vitamina D tipo I

    OpenAIRE

    Velásquez-Jones, Luis; Medeiros, Mara; Valverde-Rosas, Saúl; Jiménez-Triana, Clímaco; del Moral-Espinosa, Irma; Romo-Vázquez, José Carlos; Franco-Alvarez, Isidro

    2015-01-01

    Introducción: El raquitismo dependiente de vitamina D tipo I es una enfermedad hereditaria rara debida a una mutación en el gen CYP27B1 que codifica la enzima 1α-hidroxilasa. Se caracteriza por la presentación de raquitismo hipocalcémico grave desde la edad de la lactancia debido al déficit de producción del metabolito activo de la vitamina D, la 1α,25-dihidroxivitamina D3. Caso clínico: Presentamos el caso de un paciente con raquitismo diagnosticado a los 11 meses de edad y el seguimiento...

  2. What factors are associated with unplanned return following transurethral resection of bladder tumor? An analysis of a large single institution's experience.

    Science.gov (United States)

    Ghali, Fady; Moses, Rachel A; Raffin, Eric; Hyams, Elias S

    2016-10-01

    This study sought to evaluate factors associated with unplanned hospital return (UR) following transurethral resection of bladder tumor (TURBT), the largest source of readmission among ambulatory urological procedures. A retrospective review of TURBTs at a single academic institution between April 2011 and August 2014 was performed. Demographics, comorbidities, length of stay, tumor size and multiple other factors were recorded. UR was recorded within 30 days of surgery. Bivariate and multivariable analyses were performed to determine factors associated with UR. Among 708 patients undergoing TURBT, 23.9% were female with a mean age of 70 years. The rate of UR was 10.9%. The most common cause of UR was gross hematuria, accounting for 70%. On bivariate analysis, Foley catheter placement in the operating room, non-aspirin anticoagulation and index length of stay longer than 24 h were associated with hematuria-related UR (p hematuria-related UR (p  0.05). On multivariable analysis, only Foley placement in the operating room remained associated with higher rates of hematuria-related UR, while preoperative antibiotics, female gender and aspirin therapy remained associated with a lower likelihood of this event. UR following TURBT is common and typically results from gross hematuria. Patients with postoperative Foley catheterization in the operating room may require additional counseling or supervision before discharge, and should be considered for discharge with a Foley rather than having a prompt voiding trial.

  3. LAS DONACIONES COLACIONABLES: EL ENIGMA DE UNA INSTITUCIÓN JURÍDICA. INCIDENCIAS SUSTANTIVAS PARA EL DERECHO POSITIVO CUBANO

    Directory of Open Access Journals (Sweden)

    José Karel Fernández Martell

    2012-11-01

    Full Text Available El artículo muestra la realidad del derecho sucesorio nacional, respecto a lo inmutable que resulta en la práctica jurídica cubana de estos tiempos la aplicaciónde los preceptos contentivos de la colación hereditaria, aun cuando el alto número de casos en sede de partición y adjudicación hereditaria demuestran que los operadores jurídicos pasan por alto la institución. Ello se debe, en gran medida, a la enrevesada fórmula legal del artículo 530 del Código Civil (Repúblicade Cuba, 1987 y la exagerada economía preceptual que acompaña al texto sustantivo civil cubano al tratar insuficientemente figuras como la legítima, las operaciones para cálculo y determinación de la misma (computación o reuniónficticia, imputación, los bienes colacionables y no colacionables, las formas de extinción de la colación, etc.

  4. Possible health effects of living in proximity to mining sites near Potosí, Bolivia.

    Science.gov (United States)

    Farag, Sara; Das, Riva; Strosnider, William H J; Wilson, Robin Taylor

    2015-05-01

    The goal of this study was to determine the health effects of living downstream from mines in the Potosí region of Bolivia. Histories, physical examinations, and urinalyses were completed on adults recruited from mining and nonmining villages in Bolivia. Blood concentrations of Cd, Hg, and Pb were determined in a subset of participants. Multiple logistic regression analyses were performed. Mining region participants had significantly higher frequencies of hypertension, hematuria, and ketonuria. Hematuria was significantly elevated among those watering livestock downstream from mines and eating grains from their own farm (odds ratio = 4.3; 95% confidence interval, 1.1 to 17.7). Significantly higher blood concentrations of Pb were observed in a subsample of participants with hematuria (4.80 μg/dL vs 10.91 μg/dL; P = 0.026). Efforts to abate environmental exposure to toxic metals seem warranted.

  5. Hemangioma of the prostate--an unusual cause of lower urinary tract symptoms

    DEFF Research Database (Denmark)

    Serizawa, Reza R; Nørgaard, Nis; Horn, Thomas

    2011-01-01

    Hemangioma of the prostate gland is extremely rare and only a few cases have been reported. There have been several cases of hemangioma of posterior urethra, urinary bladder and periprostatic plexus in the literature, all presenting with hematuria or hematospermia. Diagnosis of prostatic hemangio...... is difficult due to its rarity and unspecific symptoms such as hematuria, hematospermia or lower urinary tract symptoms. It cannot be detected by conventional examinations such as cystoscopy or standard rectal ultrasonography.......Hemangioma of the prostate gland is extremely rare and only a few cases have been reported. There have been several cases of hemangioma of posterior urethra, urinary bladder and periprostatic plexus in the literature, all presenting with hematuria or hematospermia. Diagnosis of prostatic hemangioma...

  6. Diagnosis and initial management of urological injuries associated with 200 consecutive pelvic fractures.

    Science.gov (United States)

    Palmer, J K; Benson, G S; Corriere, J N

    1983-10-01

    During 26 months 200 consecutive patients with fracture of the bony pelvis were evaluated and treated for urological injury. There was no correlation between the extent of pelvic injury and degree of hematuria but hematuria was present in all patients with a urological injury. All urological injuries occurred with anterior arch fractures. The over-all incidence of injury was 13.5 per cent (bladder 9 per cent, urethra 3.5 per cent and combined 1 per cent). Limited extraperitoneal bladder ruptures were treated successfully by Foley catheter drainage.

  7. Successful Management of Neobladder Variceal Bleeding

    Energy Technology Data Exchange (ETDEWEB)

    Atwal, Dinesh; Chatterjee, Kshitij, E-mail: kchatterjee@uams.edu [University of Arkansas for Medical Sciences, Department of Internal Medicine, Residency Program: Slot 634 (United States); Osborne, Scott [University of Arkansas for Medical Sciences, Division of Interventional Radiology, Department of Radiology (United States); Kakkera, Krishna; Deas, Steven [University of Arkansas for Medical Sciences, Department of Internal Medicine, Residency Program: Slot 634 (United States); Li, Ruizong [University of Arkansas for Medical Sciences, Division of Interventional Radiology, Department of Radiology (United States); Erbland, Marcia [University of Arkansas for Medical Sciences, Department of Internal Medicine, Residency Program: Slot 634 (United States)

    2016-10-15

    Hematuria from a neobladder can occur due to a variety of pathologies including tumors, stones, and fistulas. Variceal bleeding in a neobladder is a very rare condition with only one case reported in literature. We present a case of a patient with cirrhosis and portal hypertension and an ileocolic orthotopic neobladder presenting with hematuria. Computed tomographic angiography showed dilated varices around the neobladder which were successfully embolized. To the best of our knowledge, this is the first report case of variceal bleeding in a neobladder successfully managed with the combination of TIPS (transjugular intrahepatic portosystemic shunt) procedure and embolization.

  8. Dietary dissolution of urinary calculi in cats

    International Nuclear Information System (INIS)

    Hyde, D.C.

    1987-01-01

    A young adult, castrated male DSH cat was admitted for pollakiuria, hematuria and dysuria. The cat was being fed a commercial dry grocery brand cat food. Radiographs demonstrated multiple radiodense cystic calculi and urinalysis showed hematuria but no crystalluria. A tentative diagnosis of struvite urolithiasis was made. The cat was fed s/d® Feline food exclusively. Clinical signs disappeared within a week and no calculi were visible radiographically within three weeks. s/d® Feline food was continued an additional two weeks. This case study shows that s/d® Feline therapeutic food can be used to successfully manage struvite urolithiasis in cats

  9. Imaging of the urinary tract in adults

    International Nuclear Information System (INIS)

    Aslaksen, A.; Hunskaar, S.; Hoeisaeter, P.Aa.

    1990-01-01

    This article discusses the indications for imaging of the urinary tract from the general practitioners' point of view. Urography should be used in the control of patients with previous attacks of ureteral colic, in patients presenting macroscopic hematuria and as a preoperative investigation prior to extracorporal shock wave lithotripsy (ESWL). Ultrasound should be chosen in patients with microscopic hematuria and non-specific abdominal pain. Computerized tomography should be used in cases with non-specific findings using urography and ultrasound. There are no indications for imaging in women with recurrent urinary tract infection, in men with benign prostatic hypertrophy and in the evaluation of hypertension. 14 refs., 5 tabs

  10. Imaging of the urinary tract in adults; A direction for general practice. Bildediagnostikk av urinveiene hos voksne; En rettledning for allmenpraksis

    Energy Technology Data Exchange (ETDEWEB)

    Aslaksen, A.; Hunskaar, S.; Hoeisaeter, P.Aa. (Haukeland Sykehus, Bergen (Norway))

    1990-11-01

    This article discusses the indications for imaging of the urinary tract from the general practitioners' point of view. Urography should be used in the control of patients with previous attacks of ureteral colic, in patients presenting macroscopic hematuria and as a preoperative investigation prior to extracorporal shock wave lithotripsy (ESWL). Ultrasound should be chosen in patients with microscopic hematuria and non-specific abdominal pain. Computerized tomography should be used in cases with non-specific findings using urography and ultrasound. There are no indications for imaging in women with recurrent urinary tract infection, in men with benign prostatic hypertrophy and in the evaluation of hypertension. 14 refs., 5 tabs.

  11. Mutation in the alpha 5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss or ocular lesions

    DEFF Research Database (Denmark)

    Zhou, J; Hertz, Jens Michael; Tryggvason, K

    1992-01-01

    A single base mutation was identified in the type IV collagen alpha 5 chain gene (COL4A5) of a Danish kindred with Alport syndrome. The 27-year-old male proband developed hematuria in childhood and terminal renal failure at the age of 25 years. He has no hearing loss or ocular lesions. Electron...... microscopy demonstrated splitting of the lamina densa of the glomerular basement membrane. The proband's mother has had persistent microscopic hematuria since the age of 40 years, but no other manifestations. Southern analysis of MspI-digested genomic DNA from the proband showed the absence of 1.3-kb and 0...

  12. Quiste óseo aneurismático de los maxilares. Caso clínico. Instituto Nacional de Enfermedades Neoplásicas

    OpenAIRE

    Román Pilco, Sandra; Sánchez Lihón, Juvenal

    2004-01-01

    El quiste óseo aneurismático (QOA) de los maxilares es una lesión benigna intraósea compuesta por espacios cavernosos llenos de sangre, de tamaños variables, sin recubrimiento endotelial, asociados con tejido conectivo fibroso conteniendo células gigantes multinucleadas y tejido osteoide; clínicamente el lado afecto de los maxilares aumenta de tamaño y muestra una discreta inflamación. Puede haber ligero dolor a la palpación y donde pueden faltar o desplazarse ...

  13. Tratamiento de los cuadros de dolor crónico benigno

    OpenAIRE

    Benítez del Rosario, Miguel Ángel

    2006-01-01

    El tratamiento del dolor crónico secundario a lesiones benignas depende de las características del dolor. Los fármacos disponibles son los analgésicos y los co-analgésicos. Las respuestas de los cuadros dolorosos, no obstante, es desigual, por lo que es preciso instaurar otras alternativas terapéuticas farmacológicas y no farmacológicas. Dentro de éstas destacan las intervenciones psicológicas y los programas de rehabilitación. Tratamientos alternativos como la acupuntura, o el TENS, pueden j...

  14. Estudio de la fisiología del esfínter anal interno porcino y de la rata, y de la fisiopatología de las alteraciones de la motilidad del esfínter anal interno en pacientes con fisura anal

    OpenAIRE

    Opazo Valdés, Álvaro Javier

    2011-01-01

    Descripció del recurs: el 01 setembre 2012 Las patologías anorectales benignas (fisura anal, incontinencia fecal, hemorroides) presentan una elevada prevalencia. De forma general, se desconoce la fisiopatología de estas enfermedades en las que se producen diversas alteraciones del esfínter anal interno (EAI). Los objetivos para esta tesis fueron: 1º Caracterizar los mecanismos y neurotransmisores implicados en el control del tono, la relajación y la contracción del EAI en dos modelos anima...

  15. Displasia fibrosa maxilar poliostótica en paciente tratada con pamidronato: a propósito de un caso Maxilar polyostotic fibrous dysplasia treated with pamidronate: A case report

    Directory of Open Access Journals (Sweden)

    José María López-Arcas

    2011-06-01

    Full Text Available El término displasia fibrosa hace referencia a un conjunto de lesiones óseas benignas que se caracterizan por la sustitución del tejido óseo normal por tejido conectivo. Se presenta el caso de una paciente afectada de displasia fibrosa poliostótica de predominio maxilar tratada de forma conservadora con bisfosfonatos.The term fibrous dysplasia refers to a variety of bony diseases characterized by the substituion of the bone by abnormal connective tissue. A case report of patient affected by a polyostotic form of fibrous dysplasia with an uneven evolution of its disease after being treated with pamidronate is presented.

  16. Estudio de 100 casos de hemorragia uterina con legrado-biopsia

    Directory of Open Access Journals (Sweden)

    Germán Jordán

    1953-01-01

    Full Text Available El cáncer del cuerpo uterino se presenta con mayor frecuencia en la sexta década de la vida, y en relación con el cáncer del cuello uterino en una proporción de un caso por ocho, respectivamente. Su evolución y sintomatología, mucho más benignas y lentas que las del cáncer del cuello, hacen mas fácil su tratamiento y favorable su pronostico.

  17. El diagnóstico por la imagen de las enfermedades de las glándulas salivales

    OpenAIRE

    Paz Expósito, Francisco

    2002-01-01

    Las lesiones de las glándulas salivales son relativamente frecuentes, presentando una patología tan diversa como la de cualquier otro sistema orgánico. La mayoría de las lesiones son inflamatorias, otras son de origen litiásico, algunas tienen una patogenia incierta que pueden confundirse con neoplasias malignas y, por último, hay un amplio espectro de neoplasias tanto benignas como malignas. La mayoría de los agrandamientos de las glándulas salivales están causados por procesos inflamator...

  18. Técnica quirúrgica del encondroma intermetatarsal

    OpenAIRE

    Albiol Ferrer, Josep Maria; Giralt de Veciana, Enrique; López Peñalba, C.; Marugán de los Bueis, Montse; Novel Martí, Virginia; Ogalla, José Manuel; Zalacain, Antonio; Subirana i Campà, Ma. Queralt

    1991-01-01

    DEFINICIÓN: Condroma verdadero, compuesto de células irregularmente dispuestas y cartílago hialino o fibrilar. ETIOPATOGENIA: Hoy en dia se considera al Encondroma como una formación circunscrita debido a un microtraumatismo repetitivo. que ocasiona en principio una irritación del periosteo o cartílago articular, con posterior desprendimiento, que aprovecha la rica red capilar circundante al huso para su nutrición tisular hasta formar una tumoración encondromatosa benigna.

  19. Granuloma piógeno de localización atípica: reporte de casos y revisión de la literatura

    OpenAIRE

    León Camacho, María; Yépez Guillén, Jenair del Valle; Parra Márquez, Oswaldo; Hernández V., Manuel E.

    2012-01-01

    El granuloma piógeno es una lesión mucocutánea benigna no neoplásica que afecta a tejidos periodontales y en menor grado a otras zonas de la cavidad bucal. Es una hiperplasia inflamatoria que usualmente muestra una superficie ulcerada, asociada a agentes traumáticos y a la contaminación con microflora y fluidos bucales. Esta patología se describe como el desarrollo reactivo focal de tejido fibrovascular o de granulación, con proliferación endotelial importante. El objetivo del ...

  20. Epidemiología de la infección y detección de tipos oncogenéticos del VPH por tecnología de captura de híbridos en mujeres sin aparentes factores de riesgo

    OpenAIRE

    Fuente Villarreal, David de la

    2011-01-01

    Introducción: El virus del papiloma humano (VPH) pertenece al grupo de virus con tropismo por los epitelios, infecta predominantemente la piel y las membranas mucosas produciendo proliferaciones epiteliales benignas o papilomas, que bajo ciertas circunstancias (las cuales si bien aún no han sido definidas a satisfacción, se estima que se relacionan con el estado inmunológico de la paciente, su carga genética, la presencia de ciertos receptores, así como la continua infección por diversos tipo...

  1. Biopsy study of salivary gland tumors

    OpenAIRE

    Rubio Pampín, Maria Magdalena; Hernández Melgarejo, Yasel; Sánchez Camacho, Luís Manuel; Martínez Larrarte, José Pedro

    2015-01-01

    Las neoplasias malignas y benignas de glándulas salivales pueden encontrarse en las glándulas salivales mayores (parótidas, submandibular, sublingual), así como en las innumerables glándulas salivares menores distribuidas por toda la mucosa de la cavidad bucal. Estas neoplasias dan lugar a una amplia variedad de tumores malignos y benignos. Entre el 65 y el 85 % se originan en la parótida y aproximadamente un 15 % son malignos. Nuestra investigación incluyó todos los casos con estudio biópsic...

  2. Displasia fibrosa craneofacial avanzada: a propósito de un caso

    OpenAIRE

    Natalia Ventura-Martínez; Raquel Guijarro-Martínez; Juan Diego Morales-Navarro; Ignacio Solís-García; Miguel Puche-Torres; Gonzalo Pérez-Herrezuelo Hermosa

    2014-01-01

    La displasia fibrosa (DF) es una enfermedad fibroósea benigna que consiste en el reemplazamiento de hueso normal con excesiva proliferación de tejido conectivo fibroso con estructuras óseas afuncionales. La forma de DF craneofacial es poco frecuente y no está bien definida. La afectación más frecuente en el área craneofacial se da en el cuerpo de la mandíbula y zona posterior del maxilar. Los autores describen el manejo completo y la rehabilitación funcional de un caso de displasia fibrosa de...

  3. Cystadenoma: a rare tumor originated in minor salivary gland Cistadenoma: um tumor raro em glândula salivar menor

    Directory of Open Access Journals (Sweden)

    Jean Nunes dos Santos

    2008-06-01

    Full Text Available Cystadenoma of salivary glands is an uncommon benign neoplasm that presents intraluminal papillary projections. The authors describe one case of cystadenoma located in the buccal mucosa and highlight its histomorphological features and differential diagnosis.O cistadenoma de glândula salivar é uma neoplasia benigna incomum, que exibe projeções papilíferas intraluminais. Os autores descrevem um caso de cistadenoma localizado na mucosa jugal, discutindo os aspectos histomorfológicos e o diagnóstico diferencial desse tumor.

  4. Costo-beneficio de la profilaxis antibiótica perioperatoria en los pacientes operados de hiperplasia prostática

    OpenAIRE

    Santana Sarrhy, Lourdes; Ferrán Fernández, Maité; Pisonero Socías, Juan José

    2002-01-01

    Se revisaron 98 historias clínicas de pacientes operados de hiperplasia prostática benigna en el Servicio de Urología del Hospital Clinicoquirúrgico Docente "Joaquín Albarrán; por las distintas técnicas quirúrgicas. La terapéutica antimicrobiana con kanamicina se utilizó en 41 de estos casos de forma convencional, en dosis de 10 a 15 mg/kg de peso/24 h durante 7 d y los 57 casos restantes recibieron antibioticoterapia perioperatoria con ceftriaxona, en dosis de 1 g intramuscular en el momento...

  5. Linfangioma en maxilar de un recién nacido: Reporte de un caso clínico

    OpenAIRE

    Sebastián Eduardo Miguelez; Lorena Gonzalez; Ariel Monteagudo; Christian Oscar Mosca

    2018-01-01

    Los linfangiomas son neoplasias benignas que ocurren predominantemente en la infancia, son muy infrecuentes, y nacen del sistema linfático. Cuando ocurren en la cavidad oral, la localización más común es el dorso de la lengua, seguido por los labios, la mucosa bucal, el paladar blando y el piso de la boca. La prevalencia es de 1 a 3 /10.000 nacidos vivos, afectando ambos generos por igual, involucran en un 75% la cabeza y el cuello, seguido por el tronco, abdomen y extremidades. En esta publi...

  6. Osteocondroma lumbar sintomático

    OpenAIRE

    González Darder, José M.; Barcia, Juan Antonio; Vera Roman, J. Mª; Vargas, S.

    1993-01-01

    Se presenta un caso de osteocondroma solitario espinal localizado en la zona para-articular de la lámina izquierda de L4 y que producía una lumbociática secundaria a la estenosis del receso lateral. El osteocondroma espinal sintomático es una lesión neoplásica benigna poco frecuente y cuyo tratamiento de elección es la extirpación quirúrgica. A case of solitary spinal osteochondroma growing from the left L4 lamina, close to the facet joint, is presented. The tumor produced a st...

  7. Comorbilidades y calidad de vida en Osteoartritis

    OpenAIRE

    Solis Cartas, Urbano; Calvopiña Bejarano, Silvia Johana

    2018-01-01

    RESUMEN Introducción: la osteoartritis es considerada la enfermedad reumática más antigua y frecuente que existe. A pesar de ser considerada una patología benigna se asocia a un gran número de comorbilidades que pueden influir en el curso de la enfermedad. Objetivo: determinar la influencia de las comorbilidades en la percepción de la calidad de vida relacionada con la salud en pacientes con osteoartritis del cantón Riobamba. Método: estudio descriptivo, transversal y observacional ...

  8. Caso severo de manifestaciones bucales de la hiperplasia epitelial focal

    OpenAIRE

    Jonathan Harris Ricardo; Natalia Fortich Mesa

    2012-01-01

    La hiperplasia epitelial focal, conocida también como enfermedad de Heck, es una patología benigna que se caracteriza por la presencia de múltiples pápulas en la mucosa de la cavidad bucal; es producida por los subtipos 13 y 32 del virus del papiloma humano, aunque también se le relaciona con factores genéticos, inmunosupresión e higiene bucal deficiente pero con poco sustento científico; afecta principalmente a niños y adolescentes. Se reporta caso clínico de paciente femenina de 7 años de e...

  9. Retorragia em Pequeno Lactente: Será Alergia?

    Directory of Open Access Journals (Sweden)

    Sara Narciso Ferreira

    2017-09-01

    Os autores apresentam um caso de proctocolite da infância induzida por proteínas do leite de vaca e da soja, numa lactente de dois meses de idade sob aleitamento materno exclusivo, com regressão dos sintomas após dieta materna. O nosso objetivo é relembrar esta entidade benigna, de diagnóstico clínico e que não implica a suspensão do aleitamento materno. Recebido: 03/04/2017 - Aceite: 30/05/2017

  10. Mastocitoma cutáneo solitario: presentación de un caso Solitary cutaneous mastocytoma: a case report

    Directory of Open Access Journals (Sweden)

    AD Pérez-Elizondo

    Full Text Available Se presenta el caso de un lactante menor con tumoración cutánea benigna, localizada en el área submandibular izquierda de la cabeza, característico de un mastocitoma solitario. Su reconocimiento clínico precoz y la instauración terapéutica temprana aceleraron el tiempo de resolución, casi siempre espontánea.We present a case of an infant with benign cutaneous tumor, located in the left submandibular aspect of the head consistent with solitary mastocytoma. Its early clinical recognition and early treatment onset accelerates time to resolution almost always spontaneous.

  11. Paciente con tumor de cuerpo carotideo

    Directory of Open Access Journals (Sweden)

    Mariuska Forteza Sáez

    Full Text Available Los tumores de cuerpo carotideo (paragangliomas son neoplasias altamente vascularizadas, muy poco frecuentes y generalmente benignas, originadas en los quimiorreceptores del cuerpo carotideo. Se presenta el caso de un paciente de 54 años, con aumento de volumen cervical derecho, asintomático, con estudio preoperatorio y angiografía realizados por tomografía axial computarizada, que resultan compatibles con tumor de cuerpo carotideo. Se realiza disección subadventicial, informando la biopsia paraganglioma. El tumor fue completamente resecado, sin evidencia de recurrencia y sin complicaciones.

  12. TUMOR CONDROLIPOMATOSO (CONDROLIPOMA) DE MAMA

    OpenAIRE

    Sandoval, Diana Katherine; Acevedo R, Melina; Arias V, Carmen Ligia; García A, Ernesto

    2015-01-01

    Introducción: El cartílago es un componente poco común en las lesiones de mama, la mayoría de casos corresponden a metaplasias de lesiones malignas siendo excepcional el hallazgo en lesiones benignas; estas últimas se han subclasificado de acuerdo a las características histológicas destacables para cada autor, pero globalmente se componen de tejido adiposo, estroma fibroso y cartílago, mientras que el componente epitelial mamario es de presentación variable. El condrolipoma de mama fue report...

  13. Expresión tisular de los componentes del sistema fibrinolítico y de las metaloproteasas en la endometriosis.

    OpenAIRE

    Gilabert Estellés, Juan

    2003-01-01

    RESUMEN La endometriosis es una enfermedad ginecológica caracterizada por la presencia de tejido endometrial fuera del útero. Se trata de una enfermedad muy prevalente en mujeres con dolor pélvico o esterilidad. Aunque la endometriosis es una enfermedad benigna, el tejido endometrial adquiere la capacidad de adherirse e invadir el peritoneo, produciéndose un proceso de proteolisis de la matriz extracelular (MEC). En este proceso están íntimamente implicados el sistema fibrinolítico y el de...

  14. Radiación ultravioleta y lesiones melanocíticas. Implicación en prevención y diagnóstico precoz de melanoma.

    OpenAIRE

    Carrera Álvarez, Cristina

    2013-01-01

    La radiación ultravioleta (RUV) juega un papel fundamental en el desarrollo de lesiones melanocíticas adquiridas, benignas y malignas, siendo al igual que la presencia de nevus, los principales factores de riesgo para el desarrollo de melanoma. Asimismo, las nuevas clasificaciones moleculares del melanoma han suscitado un creciente interés por el papel etiopatogénico de la RUV. A pesar de los revolucionarios avances en terapéutica, la prevención continúa siendo la pieza clave de la lucha con...

  15. Cambiando los paradigmas de la infección por M. pneumoniae en pediatría

    OpenAIRE

    Jocelin Merida-Vieyra; Alejandra Aquino-Andrade; Rosa María Ribas-Aparicio; Agustín de Colsa-Ranero

    2017-01-01

    La neumonía atípica es un término que originalmente se utilizó en pacientes adultos que presentaban neumonías de curso atípico, generalmente leves y de evolución benigna, que eran causadas por agentes como: Mycoplasma pneumoniae, Chlamydophila pneumoniae y Legionella pneumophila. En población pediátrica la presentación, tanto clínica como epidemiológica, de las neumonías por M. pneumoniae merece una especial atención ya que no siempre son cursos benignos y pueden existir numerosos cuadros ext...

  16. Desarrollo de nuevas metodologías de síntesis de O- y C-glicósidos utilizando líquidos iónicos

    OpenAIRE

    Díaz, Gisela

    2015-01-01

    El objetivo general de las tareas de investigación realizadas en esta tesis es la síntesis de derivados de hidratos de carbono, con potencial actividad biológica, mediante metodologías que procuren ser simples, eficientes, selectivas y benignas con el medio ambiente. En particular se buscó estudiar el uso de líquidos iónicos (ILs) como solventes y/o promotores de reacción. Objetivos específicos: • Sintetizar y caracterizar estructuralmente líquidos iónicos de estructuras ...

  17. Abordaje ortodóncico preliminar de un paciente con Osteocondromatosis múltiple. Reporte de Caso

    OpenAIRE

    Sandoval, Paulo; Troncoso, Pamela; Ferreira, Roxana

    2014-01-01

    La osteocondromatosis múltiple es una patología de baja prevalencia, caracterizada por la presencia de lesiones benignas formadas por cartílago hialino maduro “osteocondromas”, los que se desarrollan en la metáfisis de los huesos, próximos a las placas de crecimiento. Los problemas clínicos causados por los osteocondromas incluyen malformaciones esqueléticas, acortamiento asimétrico de las extremidades, y el riesgo potencial de transformación maligna a condrosarcoma. Reportamos el caso clínic...

  18. Clinical management of dietary induced urolithiasis associated with ...

    African Journals Online (AJOL)

    A Boer-Kajang cross male goat was presented to the Veterinary Hospital, University Malaysia Kelantan with a history of dysuria, hematuria and restlessness. The goat was intensively managed (confined to the pen) and fed with only palm kernel cake for the last three months. Physical examination revealed that the goat was ...

  19. A rare prostatic diagnosis of an old man: a pure prostatic leiomyoma

    NARCIS (Netherlands)

    Ulden-Bleumink, W.M. van; Dom, P.G.; Ramakers, B.P.C.; Adrichem, N.P. van

    2013-01-01

    A pure leiomyoma of the prostate is a rare benign tumor. An 82-year-old man was referred to our urology department with gross hematuria and complete urinary retention. Examination revealed a benign prostatic hyperplasia. Transrectal ultrasound showed a prostate of 125 mL. Serum PSA was 1.9 microg/L.

  20. Anti-alpha-galactosyl antibodies and immune complexes in children with Henoch-Schönlein purpura or IgA nephropathy

    NARCIS (Netherlands)

    Davin, J. C.; Malaise, M.; Foidart, J.; Mahieu, P.

    1987-01-01

    Episodes of hematuria in IgA nephropathy or Henoch-Schönlein purpura are frequently associated with microbial infections. Some of those infectious agents bear alpha-galactosyl residues on their cell surface. These observations prompted us to determine, by passive hemagglutination, the titers of

  1. Dissolution of infection-induced struvite bladder stones by using a noncalculolytic diet and antibiotic therapy

    Science.gov (United States)

    2004-01-01

    Abstract An 8-year-old, female spayed miniature schnauzer was presented for pollakiuria and gross hematuria. Infection-induced struvite urolithiasis with concurrent bacterial urinary tract infection was diagnosed. The treatment is described, followed by a brief discussion of struvite stones and their medical management. PMID:15532883

  2. Simultaneous uterine and urinary bladder rupture in an otherwise successful vaginal birth after cesarean delivery.

    Science.gov (United States)

    Ho, Szu-Ying; Chang, Shuenn-Dhy; Liang, Ching-Chung

    2010-12-01

    Uterine rupture is the primary concern when a patient chooses a trial of labor after a cesarean section. Bladder rupture accompanied by uterine rupture should be taken into consideration if gross hematuria occurs. We report the case of a patient with uterine rupture during a trial of labor after cesarean delivery. She had a normal course of labor and no classic signs of uterine rupture. However, gross hematuria was noted after repair of the episiotomy. The patient began to complain of progressive abdominal pain, gross hematuria and oliguria. Cystoscopy revealed a direct communication between the bladder and the uterus. When opening the bladder peritoneum, rupture sites over the anterior uterus and posterior wall of the bladder were noted. Following primary repair of both wounds, a Foley catheter was left in place for 12 days. The patient had achieved a full recovery by the 2-year follow-up examination. Bladder injury and uterine rupture can occur at any time during labor. Gross hematuria immediately after delivery is the most common presentation. Cystoscopy is a good tool to identify the severity of bladder injury. Copyright © 2010 Elsevier. Published by Elsevier B.V. All rights reserved.

  3. Simultaneous Uterine and Urinary Bladder Rupture in an Otherwise Successful Vaginal Birth After Cesarean Delivery

    Directory of Open Access Journals (Sweden)

    Szu-Ying Ho

    2010-12-01

    Full Text Available Uterine rupture is the primary concern when a patient chooses a trial of labor after a cesarean section. Bladder rupture accompanied by uterine rupture should be taken into consideration if gross hematuria occurs. We report the case of a patient with uterine rupture during a trial of labor after cesarean delivery. She had a normal course of labor and no classic signs of uterine rupture. However, gross hematuria was noted after repair of the episiotomy. The patient began to complain of progressive abdominal pain, gross hematuria and oliguria. Cystoscopy revealed a direct communication between the bladder and the uterus. When opening the bladder peritoneum, rupture sites over the anterior uterus and posterior wall of the bladder were noted. Following primary repair of both wounds, a Foley catheter was left in place for 12 days. The patient had achieved a full recovery by the 2-year follow-up examination. Bladder injury and uterine rupture can occur at any time during labor. Gross hematuria immediately after delivery is the most common presentation. Cystoscopy is a good tool to identify the severity of bladder injury.

  4. Review: The scope of clinical morbidity in sickle cell trait | Tantawy ...

    African Journals Online (AJOL)

    Although SCT was initially considered as a benign condition, data are accumulating of serious morbidities in SCT individuals including increased incidence of hematuria, renal papillary necrosis, renal failure and malignancy, thromboembolic disorders, splenic infarction as a high altitude complication, and exercise-related ...

  5. A case of transitional cell carcinoma associated with pericalyceal diverticulum diagnosed by CT guided percutaneous cystgraphy

    International Nuclear Information System (INIS)

    Sasaki, Fumio; Koga, Sukehiko; Takeuchi, Akira; Anno, Hirofumi; Hujita, Tamio

    1983-01-01

    Computed tomography (CT) performed on a 42-year-old male patient with a chief complaint of hematuria revealed a renal cyst with a thickened and irregularly shaped wall. CT with contrast medium injected into the cyst by puncture under CT guide detected tumors on the cystic wall preoperatively. (Ueda, J.)

  6. Clostridium difficile Infection

    Science.gov (United States)

    ... TeensRead MoreBMI Calculator Acute BronchitisHigh Blood PressureBursitis of the HipHigh CholesterolExercise-induced UrticariaMicroscopic HematuriaKidney CystsDe Quervain’s Tenosynovitis Home Diseases and Conditions Clostridium difficile (C. diff.) ...

  7. Emphysematous cystitis: An unusual disease of the Genito-Urinary system suspected on imaging

    Directory of Open Access Journals (Sweden)

    Sarna Pawanjit S

    2004-10-01

    Full Text Available Abstract Emphysematous cystitis is a rare disease entity caused by gas fermenting bacterial and fungal pathogens. Clinical symptoms are nonspecific and diagnostic clues often arise from the unanticipated imaging findings. We report a case of 52-year-old male who presented with fever, dysuria and gross hematuria who was found to have emphysematous cystitis.

  8. Two cases of benign polyps of the posterior urethra (ectopic prostatic tissue)

    OpenAIRE

    多田, 晃司; 山羽, 正義; 田村, 公一; 藤広, 茂; 河田, 幸道

    1990-01-01

    We report two cases of benign polyps of the posterior urethra. Their first symptoms were gross hematuria and urinary frequency. Both specimens obtained by transurethral resection were histologically identified as prostatic tissue. Discussion on benign polyps of the posterior urethra as ectopic prostatic tissue was done with review of literature.

  9. Estrogen receptors in the human male bladder, prostatic urethra, and prostate. An immunohistochemical and biochemical study

    DEFF Research Database (Denmark)

    Bødker, A; Balslev, E; Juul, B R

    1995-01-01

    The distribution and quantity of estrogen receptors (ERs) in the human male bladder, prostatic urethra and the prostate were studied in eight males with recurrent papillomas of the bladder or monosymptomatic hematuria (median age 61 years), 14 men undergoing transurethral resection due to benign...

  10. Primary diffuse large B-cell lymphoma of the prostate in a young patient

    Directory of Open Access Journals (Sweden)

    Carlos A. Alvarez

    2006-02-01

    Full Text Available We report a primary lymphoma of the prostate, which arose in a 29-year-old man with hematuria. Pathological evaluation of tissue fragments allowed us to choose appropriate medical management. A diagnosis of suspicion can be performed by urine cytology, and molecular techniques may be helpful. Emphasis in differential diagnosis is made.

  11. Intravesical instillation of Formalin for hemorrhagic cystitis secondary to radiation for gynecologic malignancies

    International Nuclear Information System (INIS)

    Behnam, K.; Patil, U.B.; Mariano, E.

    1983-01-01

    Our experience with the use of Formalin instillation in intractable gross hematuria secondary to radiation cystitis in patients with gynecological malignancies is reported. This study indicates coagulative effect of low concentration of Formalin with minimal side effects as a method to control hemorrhage

  12. ILIAC-ARTERY URETERAL-FISTULA ASSOCIATED WITH AN INDWELLING URETERAL STENT

    NARCIS (Netherlands)

    ZWEERS, HMM; VANDRIEL, MF; MENSINK, HJA

    1991-01-01

    We report on a patient with an ureteroiliac artery fistula, which developed after double J stenting. The stent was introduced because of unilateral hydronephrosis 2 months after a Wertheim-Meigs operation preceded by cesium application. The presenting symptom of gross hematuria was initially

  13. Circumcaval Ureter with Synchronous Ipsilateral Transitional Cell ...

    African Journals Online (AJOL)

    mn

    flank pain and gross hematuria of one year's duration. Clinical examination was unremarkable apart from ... ry tract stasis and a J- or fish-hook deformity of the ureter as it passes behind the inferior vena cava (IVC). ... Patients usually present with right flank pain and discomfort, which can be intermittent, dull or aching6.

  14. Short-term complications for percutaneous ultrasound-guided biopsy of renal masses in adult outpatients

    DEFF Research Database (Denmark)

    Rasmussen, Lars René; Loft, Martina; Nielsen, Tommy Kjaergaard

    2018-01-01

    intervention and two patients with septicemia. Minor complications occurred in 2.8% of cases (eight patients); six patients with self-limiting gross hematuria, one patient with small asymptomatic subcapsular hematoma, and one patient with vasovagal syncope. The timing of both minor and major complication onset...

  15. Asymptomatic renal cell carcinoma incidentally detected by abdominal CT

    International Nuclear Information System (INIS)

    Yoneda, Fumio; Miyake, Noriaki; Tsujimura, Haruhiro; Nakajima, Mikio; Akiyama, Hajime

    1987-01-01

    Four cases of renal cell carcinoma that were incidentally detected by abdominal CT are reported. Abdominal CT was performed during gastro-intestinal examination in two patients and for suspected liver disease in the other two. No patient had symptoms of renal cell carcinoma, or hematuria. In all cases, the histopathological diagnosis was renal cell carcinoma of a low stage. (author)

  16. The Nutcracker Syndrome as a Rare Cause of Chronic Abdominal Pain: A Case Report

    OpenAIRE

    Pournasiri

    2016-01-01

    Introduction Renal vein entrapment, named nutcracker phenomenon, is a contraction of renal vein between abdominal aorta and superior mesenteric artery. Patients can be asymptomatic or clinically manifested, called nutcracker syndrome. Proteinuria, hematuria, flank pain, varicocele in males and pelvic congestion in females are reported in such patients. Case Presentation The current report presented an eight-year-old girl with micr...

  17. Primary urachal adenocarcinoma: A case report

    African Journals Online (AJOL)

    I. Ziouziou

    only 0.5% of all bladder malignancies, and 20–40% of primary bladder adenocarcinomas [2–4]. Hematuria is the most common presenting symptom in about 90% of patients [5]. The MD Anderson Cancer Center (MDACC) suggested 5 criteria for the diagnosis of urachal cancers. These criteria include a mid- line location of ...

  18. 76 FR 82152 - Cyhalofop-butyl; Pesticide Tolerances

    Science.gov (United States)

    2011-12-30

    ... hematuria (gross pathological examinations revealed cloudy or dark colored kidneys). Slight kidney tubular... and the occurrence of cloudy or dark colored kidneys on gross pathological examination) were seen in... with the EPA Final Guidelines for Carcinogen Risk Assessment (March 29, 2005). UFA = extrapolation from...

  19. Diagnosis of Henoch-Schonlein purpura: renal or skin biopsy?

    NARCIS (Netherlands)

    Davin, Jean-Claude; Weening, Jan J.

    2003-01-01

    Henoch-Schonlein purpura (HSP) is a form of systemic vasculitis characterized by vascular wall deposits of predominantly IgA, typically involving small vessels in skin, gut, and glomeruli and associated with purpura, intestinal colic, hematuria, and arthralgia or arthritis. HSP nephritis leads to

  20. Cystic poorly differentiated nephroblastoma: A case report and ...

    African Journals Online (AJOL)

    M.O. Odubanjo

    Abstract. Background: Cystic poorly differentiated nephroblastoma (CPDN) is a rare variant of nephroblastoma which follows a benign clinical course. Case diagnosis/treatment: In this report, we document a case of CPDN in a 2 year old boy who pre- sented with recurrent gross painless hematuria and progressive ...

  1. Download this PDF file

    African Journals Online (AJOL)

    FOBUR

    type of occupation and hematuria (95%) as the commonest presenting symptom . Transitional Cell. Carcinoma was the commonest histological variety in our study accounting for 85.5% of cases with majority. (78%) as non-muscle invasive. The muscle invasion was directly associated with the grade of tumor. Conclusion: ...

  2. Senbivirkninger efter kurativt anlagt strålebehandling for prostata cancer

    DEFF Research Database (Denmark)

    Fokdal, Lars; Høyer, Morten

    2005-01-01

          population controls. In general, the patients' bladder function was well       preserved. However, compared with the population controls, significantly       more patients reported dysuria and hematuria. Twenty-six percent of the       patients reported moderate distress from the gastrointestinal tract...

  3. Cabazitaxel Versus Docetaxel As First-Line Therapy for Patients With Metastatic Castration-Resistant Prostate Cancer

    DEFF Research Database (Denmark)

    Oudard, Stéphane; Fizazi, Karim; Sengeløv, Lisa

    2017-01-01

    of grade 3 or 4 treatment-emergent adverse events were 41.2%, 60.1%, and 46.0% for C20, C25, and D75, respectively. Febrile neutropenia, diarrhea, and hematuria were more frequent with C25; peripheral neuropathy, peripheral edema, alopecia, and nail disorders were more frequent with D75. Conclusion C20...

  4. Prevalence and associations of symptomatic renal papillary necrosis ...

    African Journals Online (AJOL)

    Aim: To assess the prevalence and associations of symptomatic renal papillary necrosis (RPN) in sickle cell anemia patients. Patients and Methods: The case notes of homozygous hemoglobin (Hb) S patients diagnosed with RPN were retrospectively assessed. Diagnosis was based on microscopic hematuria and positive ...

  5. Mutation analysis of COL4A3 and COL4A4 genes in a Chinese ...

    Indian Academy of Sciences (India)

    2016-10-24

    ,. People's Republic of China ... mutations in COL4A3 and COL4A4 genes which encode type IV collagen α3 and α4 chainsrespectively can .... hematuria and evidence for activation of the unfolded protein response. Focal and ...

  6. Síndrome Parry-Romberg

    Directory of Open Access Journals (Sweden)

    Elayne Esther Santana Hernández

    2015-02-01

    Full Text Available El síndrome de Parry-Romberg, también conocido como hemiatrofia facial progresiva, es un síndrome neurocutáneo raro de etiología desconocida. Las principales características son la atrofia de los tejidos blandos, y algunas veces del hueso, en una mitad de la cara o parte frontal de la cabeza, sin debilitamiento facial. Estudios recientes plantean la posibilidad hereditaria de esta patología, ya que se recogen afectados en una misma familia. En este trabajo se describe un sujeto afectado que viene con su hija con una asimetría facial. Es importante el seguimiento de estos pacientes y su familia para realizar un diagnóstico que permita actuar precozmente.

  7. Síndrome de Li-Fraumeni

    OpenAIRE

    Carlos Andrés Ossa; Gustavo Molina; Alicia María Cock-Rada

    2016-01-01

    El síndrome de Li-Fraumeni se caracteriza por la aparición de tumores en múltiples órganos, generalmente a temprana edad. Esta condición hereditaria es causada por mutaciones germinales en el gen TP53, que codifica el gen supresor tumoral p53. Se presenta el caso de una paciente de 31 años con diagnóstico clínico y molecular de síndrome de Li-Fraumeni, que presentó dos tumores sincrónicos a los 31 años: un leiomiosarcoma de antebrazo y un tumor filoides de mama. Tenía el antecedente de ...

  8. Síndrome de Li-Fraumeni

    OpenAIRE

    Ossa, Carlos Andrés; Molina, Gustavo; Cock-Rada, Alicia María

    2016-01-01

    El síndrome de Li-Fraumeni se caracteriza por la aparición de tumores en múltiples órganos, generalmente a temprana edad. Esta condición hereditaria es causada por mutaciones germinales en el gen TP53 , que codifica el gen supresor tumoral p53 . Se presenta el caso de una paciente de 31 años con diagnóstico clínico y molecular de síndrome de Li-Fraumeni, que presentó dos tumores sincrónicos a los 31 años: un leiomiosarcoma de antebrazo y un tumor filoides de mama. Tenía el antecedente de un h...

  9. Caracterización molecular de pacientes con síndrome de usher mediante secuenciación Sanger de nueva generación : análisis de expresión de variantes USH1

    OpenAIRE

    Aparisi Navarro, María José

    2015-01-01

    El síndrome de Usher (USH) es una enfermedad hereditaria autosómica recesiva, caracterizada por la asociación de hipoacusia neurosensorial, retinosis pigmentaria (RP), y en algunas ocasiones, disfunción vestibular. Se considera la forma más común de sordo-ceguera de origen genético, siendo responsable de más del 50% de los individuos sordo-ciegos. Su rango de prevalencia varía entre 3,2-6,2/100000 nacidos vivos. En base a la edad de inicio, gravedad y progresión de los síntomas, el USH pue...

  10. ¿Es posible combinar lo tradicional y lo moderno?

    Directory of Open Access Journals (Sweden)

    Hugo Celso Felipe Mansilla

    2001-01-01

    Full Text Available En contra de las actuales tendencias posmodérnicas, el autor postula una simbiosis entre los elementos positivos de lo premoderno y los correspondientes de la modernidad. Cree posible rescatar las llamadas tradiciones razonable, y combinarlas con lo positivo de la modernidad. Estos factores positivos de la tradicionalidad serían la religión en cuanto fuente de sentido y consuelo, la monarquía y la aristocracia hereditarias como modelos institucionales que nos unen con la historia, y la concepción del arte y la literatura como una estética fundamentada en lo bello. Esfuerzos sincretistas similares constituyen gran parte de la historia universal.

  11. Glomerulonefritis difusa aguda postestreptocócica-psoriasis guttata: A propósito de un caso clínico

    OpenAIRE

    Mazini, Biviana; Perdomo, Virginia; Montano, Alicia; Nicoletti, Sofía; Rebori, Anabella

    2015-01-01

    La glomerulonefritis asociada a la infección por estreptococo beta hemolítico del grupo A es la más conocida y es la causa más común de síndrome nefrítico en la edad pediátrica. La psoriasis es una enfermedad cutánea hereditaria eritematodescamativa poco frecuente, representa el 4,1% de las dermatosis que ocurren en niños menores de 16 años. Se presenta el caso de un adolescente de 12 años donde la infección por estreptococo beta hemolítico del grupo A de las vías respiratorias altas ocasionó...

  12. Diagnóstico clínico de la enfermedad Charcot-Marie-Tooth

    Directory of Open Access Journals (Sweden)

    Yuselis Pérez Cid

    2014-08-01

    Full Text Available La enfermedad de Charcot-Marie-Tooth es un trastorno polineuropático genéticamente heterogéneo, en la que se han identificado más de 30 genes responsables; sin embargo, el diagnóstico es posible establecerlo sobre las bases de los estudios clínicos y electrofisiológicos. Constituye un reto en la práctica médica de los países del tercer mundo contar con la realización sistemática de estudios genéticos moleculares de las neuropatías hereditarias, por lo que en este trabajo se enfatiza en los estudios clínico-electrofisiológicos para la clasificación de la CMT

  13. El asesoramiento genético en los déficits visuales y auditivos

    OpenAIRE

    Millán, J.M.; Aller, E.; Jaijo, T.; Grau, E.; Beneyto, M.; Nájera, C.

    2008-01-01

    Objetivo: Las enfermedades hereditarias que afectan a la retina y la audición presentan una amplia heterogeneidad clínica y genética. Durante la pasada década se han producido importantes avances en el conocimiento de la patogenia molecular de estas enfermedades y, actualmente, más de 200 genes y loci están implicados en enfermedades de la retina y más de 60 son responsables de pérdida de audición. Método: El estudio genético molecular es crucial para confirmar el diagnóstico clínico, permite...

  14. Algunos aspectos hereditarios y ambientales en casos de fibrosis quística en la ciudad de Cartagena (Colombia

    Directory of Open Access Journals (Sweden)

    Dacia Malambo

    2008-01-01

    Full Text Available Objetivos: Describir las características de la transmisión hereditaria de la enfermedad en familias de la ciudad de Cartagena (Colombia y analizar algunos factores medioambientales del núcleo familiar de los pacientes que pudieran influir en la evolución y/o severidad de la patología. Materiales y métodos: Se estudiaron 22 pacientes, distribuidos en 16 familias, del “Programa de atención integral a pacientes con fibrosis quística” de la Universidad de Cartagena. Se recopiló información acerca de las condiciones de vivienda del grupo familiar y se evaluaron aspectos fenotípicos hereditarios, y se construyeron genealogías para esta enfermedad. Resultados: El análisis de pedigríes reveló lo siguiente: en ocho familias (67%, los individuos afectados presentan rasgos caucásicos; en cinco familias (42% se reconoce existencia de ancestros europeos; en dos familias (17% existe consaguinidad. En relación con el aspecto ambiental, se encontró que 33% de las familias estudiadas habitan viviendas en malas condiciones. Conclusiones: Entre las familias de los pacientes con fibrosis quística de la ciudad de Cartagena detectados en este estudio se verifica la transmisión hereditaria autosómica recesiva, se confirma el mestizaje de nuestras poblaciones. La reincidencia de enfermos y la consanguinidad en varias familias denota la falta de asesoramiento genético y el desconocimiento de la evolución de la enfermedad por su grupo familiar. Estos resultados pueden ser el punto de partida de estudios más amplios que sirvan de fundamento para la implementación de políticas tendientes a reducir la frecuencia y severidad de la enfermedad a nivel local y nacional.

  15. Otitis Media Supuratif Kronik pada Anak

    Directory of Open Access Journals (Sweden)

    Muhamad Faris Pasyah

    2016-02-01

    Otitis media supuratif kronik (OMSK merupakan masalah pada anak dan remaja yang berdampak pada fisik, sosial serta psikologis dan mempunyai prevalensi yang tinggi. Kondisi ini merupakan proses peradangan akibat infeksi mukoperiosteum rongga telinga tengah yang ditandai oleh perforasi membran timpani dan keluar sekret yang terus menerus atau hilang timbul selama 3 bulan, serta dapat menyebabkan perubahan patologik yang permanen. Tujuan penelitian mengetahui gambaran OMSK pada anak. Penelitian dilakukan secara deskriptif retrospektif di poliklinik Otologi Departemen Ilmu Kesehatan Telinga Hidung Tenggorokan-Kepala Leher (THT-KL RS Dr. Hasan Sadikin Bandung periode Januari 2012–Desember 2013. Diagnosis ditegakkan berdasarkan anamnesis dan pemeriksaan fisis. Didapatkan pasien OMSK anak laki-laki 53% dan pasien anak perempuan 47%. Jumlah OMSK tipe benigna 83% dan tipe maligna 17%. Komplikasi terbanyak OMSK pada anak adalah mastoiditis 32%. Angka putus berobat pada pasien anak dengan OMSK sebesar 60%. Simpulan, penderita OMSK pada anak lebih banyak pada laki-laki tipe benigna dan angka pasien putus berobat masih banyak ditemukan.

  16. Tumores de glándulas salivales: Su comportamiento en 10 años de trabajo (1993-2002

    Directory of Open Access Journals (Sweden)

    Oscar García-Roco Pérez

    2003-12-01

    Full Text Available Se realizó un estudio descriptivo de 107 pacientes que fueron intervenidos quirúrgicamente debido a afecciones en glándulas salivales, durante un período de 10 años, en el Servicio de Cirugía Maxilofacial del Hospital Provincial Docente "Manuel Ascunce Domenech" de Camagüey, con el propósito de describir su frecuencia según edad y sexo, comportamiento biológico, localización anatómica y resultado histopatológico. Hubo predominio de las condiciones neoplásicas benignas en la parótida, mientras que en la submandibular se manifestaron con mayor frecuencia los procesos malignos. El adenoma pleomorfo fue el tumor más frecuente entre las neoplasias benignas y el carcinoma mucoepidermoide, el más común entre las malignas.A descriptive study of 107 patients, who had been surgically treated from salivary gland tumors in the Maxillofacial Surgery Department of "Manuel Ascunce Domenech" provincial teaching hospital located in Camagüey during 10 years, was performed to describe the sex and age distribution and frequency of these tumors, their biological behavior, anatomical location and histopathological outcome. It was observed that benign neoplasias predominated in the parotid glands whereas malignant processes developed more often in submandibular glands. Pleomorphic adenoma was the most found tumor among the benign neoplasias and mucoepidermoid carcinoma was the commonest among the malignant processes.

  17. Correlación clínico-histológica de la nefritis lúpica

    Directory of Open Access Journals (Sweden)

    Digna Ma. Espinosa López

    2000-06-01

    Full Text Available Se revisaron un total de 643 biopsias renales a pacientes ingresados en el Servicio de Nefrología del Hospital Pediátrico Universitario "Centro Habana" en el período comprendido entre enero de 1988 y diciembre de 1998; de éstas se seleccionaron 29 correspondientes a nefritis lúpica, para el 4,51 %. En el momento del diagnóstico, 25 pacientes tenían más de 6 años de edad (86,2 %, con predominio del sexo femenino, 20 pacientes, para el 68,9 %. En el 75,86 % de los casos estuvieron presentes las alteraciones renales, 7 pacientes con síndrome nefrótico, 11 con ematuria, 3 con hipertensión arterial y 1 con síndrome nefrítico-nefrótico e insuficiencia renal crónica. Otras manifestaciones clínicas frecuentes fueron la artritis en el 48,27 % y el eritema facial (37,93 %. Según la clasificación histológica, 12 pacientes mostraron nefritis lúpica clase II; 8, clase I e igual cantidad clase IV y 1 caso con clase III. En el estudio del tejido renal al microscopio de inmunofluorescencia se hallaron los depósitos de inmunoglobulinas y fracciones del complemento hemolítico característico de la enfermedad. En la correlación entre las manifestaciones clínicas y la clasificación histológica, se encontró en la nefritis clase I, que las alteraciones renales que se presentaron fueron síndrome nefrótico y hematuria; en la clase II, síndrome nefrótico, hematuria e hipertensión arterial; en la clase III, hematuria en la clase IV, síndrome nefrótico, hematuria, hipertensión arterial, síndrome nefrítico-nefrótico e insuficiencia renal crónica.A total of 643 renal biopsies of patients admitted to the Service of Nephrology of University Pediatric Hospital in Centro Habana from January 1988 to December 1998 were examined, of which 29 corresponding to lupus nephritis were selected, accounting for 4.51% of the total. At the moment of the diagnosis, 25 patients were over six years-old (86.2% with predominance of females with 20 patients

  18. Human papillomavirus in oral lesions Virus papiloma humano en lesiones orales

    Directory of Open Access Journals (Sweden)

    Joaquín V. Gónzalez

    2007-08-01

    Full Text Available Growing evidence suggests a role for human papillomavirus (HPV in oral cancer; however its involvement is still controversial. This study evaluates the frequency of HPV DNA in a variety of oral lesions in patients from Argentina. A total of 77 oral tissue samples from 66 patients were selected (cases; the clinical-histopathological diagnoses corresponded to: 11 HPV- associated benign lesions, 8 non-HPV associated benign lesions, 33 premalignant lesions and 25 cancers. Sixty exfoliated cell samples from normal oral mucosa were used as controls. HPV detection and typing were performed by polymerase chain reaction (PCR using primers MY09, 11, combined with RFLP or alternatively PCR using primers GP5+, 6+ combined with dot blot hybridization. HPV was detected in 91.0% of HPV- associated benign lesions, 14.3% of non-HPV associated benign lesions, 51.5% of preneoplasias and 60.0% of cancers. No control sample tested HPV positive. In benign HPV- associated lesions, 30.0% of HPV positive samples harbored high-risk types, while in preneoplastic lesions the value rose to 59.9%. In cancer lesions, HPV detection in verrucous carcinoma was 88.9% and in squamous cell carcinoma 43.8%, with high-risk type rates of 75.5% and 85.6%, respectively. The high HPV frequency detected in preneoplastic and neoplastic lesions supports an HPV etiological role in at least a subset of oral cancers.Crecientes evidencias sugieren que el virus Papiloma humano (HPV tiene un rol en el cáncer oral; sin embargo su participación es todavía controvertida. Este estudio evalúa la frecuencia de ADN de HPV en una variedad de lesiones orales de pacientes de Argentina. Se seleccionaron 77 muestras de tejido oral de 66 pacientes (casos; el diagnóstico histo-patológico correspondió a: 11 lesiones benignas asociadas a HPV, 8 lesiones benignas no asociadas a HPV, 33 lesiones premalignas y 25 cánceres. Como controles se usaron 60 muestras de células exfoliadas de mucosa oral normal. La

  19. Nutcracker or left renal vein compression phenomenon: multidetector computed tomography findings and clinical significance

    International Nuclear Information System (INIS)

    Cuellar i Calabria, Hug; Quiroga Gomez, Sergi; Sebastia Cerqueda, Carmen; Boye de la Presa, Rosa; Miranda, Americo; Alvarez-Castells, Agusti

    2005-01-01

    The use of multidetector computed tomography (MDCT) in routine abdominal explorations has increased the detection of the nutcracker phenomenon, defined as left renal vein (LRV) compression by adjacent anatomic structures. The embryology and anatomy of the nutcracker phenomenon are relevant as a background for the nutcracker syndrome, a rare cause of hematuria as well as other symptoms. MDCT examples of collateral renal vein circulation (gonadal, ureteric, azygous, lumbar, capsular) and aortomesenteric (anterior) and retroaortic (posterior) nutcracker phenomena in patients with no urologic complaint are shown as well as studies performed on patients with gross hematuria of uncertain origin. Incidental observation of collateral veins draining the LRV in abdominal MDCT explorations of asymptomatic patients may be a sign of a compensating nutcracker phenomenon. Imbalance between LRV compression and development of collateral circulation may lead to symptomatic nutcracker syndrome. (orig.)

  20. Transitional cell carcinomas in four fishing cats (Prionailurus viverrinus).

    Science.gov (United States)

    Sutherland-Smith, Meg; Harvey, Catherine; Campbell, Mark; McAloose, Denise; Rideout, Bruce; Morris, Patrick

    2004-09-01

    Transitional cell carcinomas (TCC) of the urinary bladder were diagnosed in four related fishing cats (Prionailurus viverrinus). The major clinical sign in each case was persistent hematuria unresponsive to medical therapy. Cystotomy and biopsy provided an antemortem diagnosis in three of the fishing cats before euthanasia because of progression of clinical signs. The diagnosis was made in the fourth cat after euthanasia because of renal failure. Hematuria improved temporarily in one of the cats diagnosed antemortem and treated with piroxicam and carboplatin. Attempts to isolate a herpesvirus in two of the cats failed. Histopathologic appearance of the TCC was similar to that described for other species. TCC metastasis to the lungs was noted at necropsy in one cat; metastatic disease was not noted in the other fishing cats on gross or histopathologic examination. TCC of the urinary bladder appears to be more prevalent in fishing cats than in other species of domestic or nondomestic felids.

  1. Pelvic fracture and injury to the lower urinary tract.

    Science.gov (United States)

    Spirnak, J P

    1988-10-01

    The presence of a urologic injury must be considered in all patients with pelvic fracture. Uroradiographic evaluation starting with retrograde urethrography is indicated in all male patients with concomitant gross hematuria, bloody urethral discharge, scrotal or perineal ecchymosis, a nonpalpable prostate on rectal examination, or an inability to urinate. If the urethra is normal, a catheter may be passed, and in the presence of gross hematuria, a cystogram must be performed. Female patients rarely suffer urethral lacerations. The urethra is examined, and a Foley catheter may be passed without a urethrogram. The immediate management of associated urologic injuries continues to evolve and evoke controversy. Selected cases of extraperitoneal bladder perforation may be safely managed solely by catheter drainage. Intraperitoneal perforations require surgical exploration and repair. Urethral disruption (partial or complete) may be safely managed by primary cystostomy drainage with management of potential complications (stricture, impotence, incontinence) in 4 to 6 months.

  2. Perforation of the Urinary Bladder Caused by Transurethral Insertion of a Pencil for the Purpose of Masturbation in a 29-Year-Old Female

    Directory of Open Access Journals (Sweden)

    Athanasios Bantis

    2010-01-01

    Full Text Available The urethra is a usual site of introduction of foreign bodies for autoerotic stimulation. We present an unusual case of bladder perforation caused by foreign body that was self-inserted in the urethra and consequently slipped inside the bladder in a 29-year-old female patient with psychiatric disease. The patient was referred to our department for macroscopic hematuria and abdominal pain. Imaging studies revealed the presence of a foreign body in the pelvic area which had perforated the left lateral wall of the bladder. The foreign body was removed via open cystotomy. In psychiatric patients hematuria and pelvic pain may result from insertion of a foreign body in the bladder usually during masturbation.

  3. Youssef’s Syndrome following Cesarean Section

    Directory of Open Access Journals (Sweden)

    Ozer Birge

    2015-01-01

    Full Text Available Youssef’s syndrome is characterized by cyclic hematuria (menouria, absence of vaginal bleeding (amenorrhea, and urinary incontinence due to vesicouterine fistula (VUF, the least common of the urogynecological fistulas. Youssef’s syndrome has a variable clinical presentation. A vesicouterine fistula is an abnormal pathway between the bladder and the uterus. The most common cause is lower segment Cesarean section. Conservative treatment may be appropriate in some cases, but surgery is the definitive treatment. Vesicouterine fistula should be suspected in cases presenting with urinary incontinence even years after Cesarean section. Diagnostic tests as well as necessary appropriate surgery should be performed on cases with suspected vesicouterine fistula. We present a 40-year-old multiparous woman with vesicouterine fistula after primary Cesarean section; she presented with urinary incontinence, hematuria, and amenorrhea 1 year after the birth. Here, we discuss our case with the help of previously published studies found in the literature.

  4. Nutcracker or left renal vein compression phenomenon: multidetector computed tomography findings and clinical significance

    Energy Technology Data Exchange (ETDEWEB)

    Cuellar i Calabria, Hug; Quiroga Gomez, Sergi; Sebastia Cerqueda, Carmen; Boye de la Presa, Rosa; Miranda, Americo; Alvarez-Castells, Agusti [Hospitals Universitaris Vall D' Hebron, Institut de Diagnostic Per La Imatge, Servei De Radiodiagnostic, Barcelona (Spain)

    2005-08-01

    The use of multidetector computed tomography (MDCT) in routine abdominal explorations has increased the detection of the nutcracker phenomenon, defined as left renal vein (LRV) compression by adjacent anatomic structures. The embryology and anatomy of the nutcracker phenomenon are relevant as a background for the nutcracker syndrome, a rare cause of hematuria as well as other symptoms. MDCT examples of collateral renal vein circulation (gonadal, ureteric, azygous, lumbar, capsular) and aortomesenteric (anterior) and retroaortic (posterior) nutcracker phenomena in patients with no urologic complaint are shown as well as studies performed on patients with gross hematuria of uncertain origin. Incidental observation of collateral veins draining the LRV in abdominal MDCT explorations of asymptomatic patients may be a sign of a compensating nutcracker phenomenon. Imbalance between LRV compression and development of collateral circulation may lead to symptomatic nutcracker syndrome. (orig.)

  5. An unusual electrical burn caused by alkaline batteries

    Directory of Open Access Journals (Sweden)

    Tyng-Luen Roan

    2015-02-01

    Full Text Available Electrical burns caused by low-voltage batteries are rarely reported. We recently encountered a male patient who suffered from a superficial second-degree burn over his left elbow and back. The total body surface area of the burn was estimated to be 6%. After interviewing the patient, the cause was suspected to be related to the explosion of a music player on the left-side of his waist, carried on his belt while he was painting a bathroom wall. Elevated creatine kinase levels and hematuria indicated rhabdomyolysis and suggested an electrical burn. Initial treatment was done in the burn intensive care unit with fluid challenge and wound care. The creatine kinase level decreased gradually and the hematuria was gone after 4 days in the intensive care unit. He was then transferred to the general ward for further wound management and discharged from our burn center after a total of 11 days without surgical intervention.

  6. Lymphangioma involving the urogenital system in childhood

    Directory of Open Access Journals (Sweden)

    Michael Yap

    2015-10-01

    Full Text Available Lymphangioma of the urogenital system is extremely rare and we present two cases treated at our institution over a one year period. The first case is a 3 year-old boy who presented with scrotal swelling and was initially thought to have a complex hydrocele. On surgical exploration, an extratesticular multiloculated cystic mass was discovered and testis-sparing excision of the mass was performed. Pathology revealed lymphangioma. The second case is a 5 year-old male who initially presented with gross hematuria. Ultrasound was unremarkable but cystoscopy revealed varicosities extending from the bladder wall. On transurethral resection, histology showed non-specific benign vascular malformation. Magnetic resonance imaging (MRI was obtained because of persistent hematuria and showed multiple bladder lesions suggestive of lymphatic malformation. Partial cystectomy was ultimately performed and histology confirmed lymphangioma. To the author's knowledge, this represents the fifth reported case of lymphangioma of bladder.

  7. Transcatheter arterial embolization for congenital renal arteriovenous malformation

    International Nuclear Information System (INIS)

    Zhou Jun; Hu Tingyang; Yuan Jianhua; Yu Wenqiang

    2008-01-01

    Objective: To evaluate the effectiveness of transcatheter arterial embolization for congenital renal arteriovenous malformation. Methods: Seven cases of congenital renal arteriovenous malformation causing gross hematuria were retrospectively studied. All of 7 cases were demonstrated by means of angiography and then the catheter was placed superselectively into the involved arterial end of the malformation undertaking embolization with gelfoam, dehydrated ethanol, coils, etc. Results: All the malformations of the 7 cases were successfully embolized with stoppage of gross hematuria within 24 hours. No serious complications occurred except lumbago, fever, gastrointestinal reaction for one week. There was no recurrence of haematuria and the renal function was also normal in all cases during the follow-up for 36 to 98 months. Conclusions: Transcatheter renal arterial angiography and embolization are the important and effective management for the diagnosis and treatment of congenital renal arteriovenous malformation. (authors)

  8. Atypical Plasmacytic Proliferation in a Case of C3 Glomerulopathy

    Directory of Open Access Journals (Sweden)

    Osama Elfituri MD

    2017-02-01

    Full Text Available An 11-year-old Hispanic female underwent evaluation of asymptomatic proteinuria and hematuria. The patient denied fever, edema, and gross hematuria. Urinalysis showed mild proteinuria, and a urine microscopic examination revealed red blood cells. Screening tests for glomerulonephritis revealed a low C3 and negative ANA, ASO, DNAse-B, and ANCA. Histological examination of a renal biopsy specimen showed glomeruli with endocapillary proliferation, a predominant C3 deposition in the capillary loops by immunofluorescence, and electron dense deposits in the mesangium, paramesangium, and capillary walls by electron microscopy consistent with a diagnosis of C3 glomerulopathy. An interstitial plasmacytosis was also present with focal clustering of plasma cells, which were found to be kappa light chain restricted by in situ hybridization suggestive of a clonal proliferation. One can speculate that these plasma cells may be directly responsible for the renal pathology that was seen.

  9. Nutcracker Syndrome Accompanying Pelvic Congestion Syndrome; Color Doppler Sonography and Multislice CT Findings: A Case Report

    International Nuclear Information System (INIS)

    Inal, Mikail; Karadeniz Bilgili, Mihrace Yasemin; Sahin, Safa

    2014-01-01

    Nutcracker syndrome (NCS) is a rare pathology, caused by compression of the left renal vein (LRV) between the abdominal aorta (AA) and the superior mesenteric artery (SMA), due to reduction of the angle between AA and SMA. This leads to LRV varices, left gonadal vein varices and therefore, the pelvic congestion syndrome. For this reason, coexistence of NCS and pelvic congestion syndrome has been described. It manifests by hematuria, proteinuria, and nonspecific pelvic pain secondary to pelvic congestion, dyspareunia and persistent genital arousal. We report a 27-year-old woman who experienced hematuria and left flank pain. The diagnosis of NCS accompanied by pelvic congestion syndrome was missed initially, but later on the diagnosis was made by color Doppler ultrasound, abdominal computed tomography (CT) and CT angiography that were later performed. She refused interventional and surgical treatments, and was lost to follow up

  10. Klossiella equi Infection in an Immunosuppressed Horse: Evidence of Long-Term Infection

    Directory of Open Access Journals (Sweden)

    Lora R. Ballweber

    2012-01-01

    Full Text Available A 13-year-old quarter horse gelding presented with a history of hematuria of approximately 1-year duration, anemia, weight loss over the previous six months, and bilateral nasal discharge of 2-week duration. It was determined that hematuria was most likely caused by the coccidian parasite Klossiella equi. Additional case workup suggested a diagnosis of pituitary pars intermedia dysfunction. Confirmatory testing was declined by the owners and the horse was discharged on medical therapy. Despite initial improvement after discharge, the horse developed unresolving sinusitis approximately 1 year later and was euthanized. Necropsy confirmed the presence of an adenoma of the pars intermedia of the pituitary gland, supporting the initial diagnosis. Additional findings included multiple developmental stages of K. equi present in the kidneys. This finding demonstrates infections with K. equi can be chronic in nature and supports the association of increased severity of klossiellosis and impaired immune function.

  11. My Personal Journey With Ovarian Cancer Treatment: Caring and Chemotherapy Tips.

    Science.gov (United States)

    Decker, Kim A

    2016-12-01

    Six years ago, I was diagnosed with stage IIIA ovarian low malignant cell potential cancer. It was the most shocking situation I have ever experienced. I didn't realize I had any symptoms, except occasional back pain, which I attributed to starting a new workout program. I had scheduled an abdominal computerized tomography (CT) scan for recurrent microscopic hematuria, which my internist wanted to check. I was told I would hear the results in two days. Two hours after my CT scan, while I was eating ice cream and watching television, an on-call genitourinary doctor (who I did not personally know) called to tell me the good news-that I had kidney stones, thus the microscopic hematuria. However, the bad news was that I had ovarian cancer that had spread to my omentum. He said he would call my gynecologist right away.

  12. Upper urinary tract damage caused by ketamine snorting—A report of nine cases

    OpenAIRE

    Hsiang-Ying Lee; Yu-Chao Hsu; Chao-Yu Hsu; Eric Chieh-Lung Chou; Ching-Chia Li; Yung-Shun Juan; Mei-Yu Jang

    2015-01-01

    Objective: The toxicity of ketamine to genitourinary system not only involved in lower urinary tract, which include urinary frequency, urgency, suprapubic pain, dysuria and hematuria, but also upper urinary tracts. However, the reports of ketmaine-induced upper urinary tract damage were rare. Materials and methods: Herein, we reported nine ketamine abusers presented with moderate flank pain with hydronephrosis and lower urinary tract symptoms from three medical centers located around Taiwa...

  13. Henoch-Schönlein purpura nephritis occurring postpartum in a patient with anti-PL-7 anti-synthetase syndrome.

    Science.gov (United States)

    Nagai, Kojiro; Kishi, Jun; Morizumi, Shun; Minakuchi, Jun; Bando, Yoshimi; Nishioka, Yasuhiko; Doi, Toshio

    2017-09-01

    A 37-year-old pregnant woman developed purpura which was subsequently diagnosed as Henoch-Schönlein purpura (HSP). After childbirth, the patient developed proteinuria and hematuria. Further examination revealed that the HSP nephritis (HSPN) was associated with anti-threonyl-tRNA synthetase anti-synthetase syndrome. The onset of HSPN during pregnancy or after childbirth is rare. Moreover, to our knowledge, this is the first case to describe renal involvement in anti-synthetase syndrome.

  14. Distrofia corneana polimorfa posterior em Síndrome de Alport

    OpenAIRE

    Godoy, Flavia Ribeiro Monteiro de; Qahtani, Elham Al; Lyons, Christopher J.

    2016-01-01

    ABSTRACT We describe a six-year-old boy with a history of hematuria, posterior polymorphous corneal dystrophy and dots and fleck retinopathy. Alport syndrome should be ruled out in patients presenting with posterior polymorphous corneal dystrophy or anterior lenticonus and a family history of renal disease. RESUMO Descrevemos um paciente de 6 anos de idade com história de hematúria, distrofia corneana polimorfa posterior e retinopatia em "dots and flecks". Síndrome de Alport deve ser exclu...

  15. Endometrioid carcinoma of the upper urinary tract

    Directory of Open Access Journals (Sweden)

    Kulkarni Jagdeesh

    2010-01-01

    Full Text Available Herein, we report a second case of endometrioid carcinoma of the upper urinary tract presenting 17 years after hysterectomy for high grade adenocarcinoma of ovary. A 51-year-old nullipara presented to us with a complaint of hematuria. After complete work up, she underwent right radical nephro-ureterectomy with bladder cuff excision. The histology showed endometrioid carcinoma of upper urinary tract without any evidence of endometriosis.

  16. Genetic Modeling of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy

    Science.gov (United States)

    2016-10-01

    symptoms. c. Completed statistical analysis of urinary frequency, hematuria, and rectal bleeding using all cohorts and decreased urinary stream among...three cohorts. For each endpoint, we tested the null hypothesis of no association between each SNP and 2-year toxicity using multivariable logistic...major goals of the project?  Validate previously discovered SNPs and identify additional SNPs via meta-analysis of GWAS using a substantially

  17. Urologic Outcomes of Children With Hemorrhagic Cystitis After Bone Marrow Transplant at a Single Institution.

    Science.gov (United States)

    Au, Jason K; Graziano, Christopher; Elizondo, Rodolfo A; Ryan, Sheila; Roth, David R; Koh, Chester J; Gonzales, Edmond T; Tu, Duong T; Janzen, Nicolette; Naik, Swati; Seth, Abhishek

    2017-03-01

    To analyze clinical outcomes and the risk factors associated with genitourinary (GU) morbidity and mortality in children who present with hemorrhagic cystitis (HC) after bone marrow transplant (BMT). A retrospective chart review of patients with HC who had undergone BMT at a single pediatric hospital from 2008 to 2015 was conducted. Demographic data, severity of hematuria, HC management, and mortality were analyzed. Bivariate analysis and binary logistic regression were performed to identify risk factors. Out of 43 patients who met inclusion criteria, 67.4% were male with a median age at BMT of 10.2 years (interquartile range 5.8-14.6). Percutaneous nephrostomy catheters were inserted in 5 patients for urinary diversion. All-cause mortality was 32.6% (N = 14). Intravesical retroviral therapy (P hematuria time (P hematuria (P = .032) were associated with significant GU morbidity on bivariate analysis. On multivariable analysis, days to most improved hematuria was associated with significant GU morbidity odds ratio of 1.177 (1.006-1.376) (P = .042). Status of percutaneous nephrostomy was not associated with increased mortality (P = .472); however, in the multivariate model, BK viremia (P = .023), need for renal dialysis (P = .003), and presence of Foley catheter (P = .005) were associated with increased mortality. Children with HC after BMT fall in a very high-risk category with high mortality and significant GU morbidity. The presence of a Foley catheter, need for dialysis, and BK viremia are associated with increased mortality. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Delayed Diagnosis of Iatrogenic Bladder Perforation in a Neonate

    Directory of Open Access Journals (Sweden)

    Antoinette S. Birs

    2016-01-01

    Full Text Available Iatrogenic bladder injuries have been reported in the neonate during umbilical artery/vein catheterization, voiding cystourethrogram, urinary catheterizations, and overwhelming hypoxic conditions. Patients with iatrogenic bladder perforations can present with acute abdomen indicating urinary peritonitis, septic-uremic shock, or subtle symptoms like abdominal distension, pain, hematuria, uremia, electrolyte imbalances, and/or difficulty urinating. The following neonatal case report of perforated bladder includes a review of the signs, symptoms, diagnostic tools, and management of bladder injury in neonates.

  19. Long-term Results of Endovascular Stent Graft Placement of Ureteroarterial Fistula

    Energy Technology Data Exchange (ETDEWEB)

    Okada, Takuya, E-mail: okabone@gmail.com; Yamaguchi, Masato, E-mail: masato03310402@yahoo.co.jp [Kobe University Hospital, Department of Radiology (Japan); Muradi, Akhmadu, E-mail: muradiakhmadu@gmail.com; Nomura, Yoshikatsu, E-mail: y_katsu1027@yahoo.co.jp [Kobe University Hospital, Center for Endovascular Therapy (Japan); Uotani, Kensuke, E-mail: uotani@tenriyorozu.jp [Tenri Hospital, Department of Radiology (Japan); Idoguchi, Koji, E-mail: idoguchi@ares.eonet.ne.jp [Kobe University Hospital, Center for Endovascular Therapy (Japan); Miyamoto, Naokazu, E-mail: naoka_zu@yahoo.co.jp; Kawasaki, Ryota, E-mail: kawaryo1999@yahoo.co.jp [Hyogo Brain and Heart Center at Himeji, Department of Radiology (Japan); Taniguchi, Takanori, E-mail: tan9523929@yahoo.co.jp [Tenri Hospital, Department of Radiology (Japan); Okita, Yutaka, E-mail: yokita@med.kobe-u.ac.jp [Kobe University Hospital, Department of Cardiovascular Surgery (Japan); Sugimoto, Koji, E-mail: kojirad@med.kobe-u.ac.jp [Kobe University Hospital, Department of Radiology (Japan)

    2013-08-01

    PurposeTo evaluate the safety, efficacy, and long-term results of endovascular stent graft placement for ureteroarterial fistula (UAF).MethodsWe retrospectively analyzed stent graft placement for UAF performed at our institution from 2004 to 2012. Fistula location was assessed by contrast-enhanced computed tomography (CT) and angiography, and freedom from hematuria recurrence and mortality rates were estimated.ResultsStent graft placement for 11 UAFs was performed (4 men, mean age 72.8 {+-} 11.6 years). Some risk factors were present, including long-term ureteral stenting in 10 (91 %), pelvic surgery in 8 (73 %), and pelvic radiation in 5 (45 %). Contrast-enhanced CT and/or angiography revealed fistula or encasement of the artery in 6 cases (55 %). In the remaining 5 (45 %), angiography revealed no abnormality, and the suspected fistula site was at the crossing area between urinary tract and artery. All procedures were successful. However, one patient died of urosepsis 37 days after the procedure. At a mean follow-up of 548 (range 35-1,386) days, 4 patients (36 %) had recurrent hematuria, and two of them underwent additional treatment with secondary stent graft placement and surgical reconstruction. The hematuria recurrence-free rates at 1 and 2 years were 76.2 and 40.6 %, respectively. The freedom from UAF-related and overall mortality rates at 2 years were 85.7 and 54.9 %, respectively.ConclusionEndovascular stent graft placement for UAF is a safe and effective method to manage acute events. However, the hematuria recurrence rate remains high. A further study of long-term results in larger number of patients is necessary.

  20. Nephrogenic adenoma of the bladder in a prune belly syndrome patient: case report and review of the literature.

    Science.gov (United States)

    Broecker, Justine S; Steelman, Charlotte K; Broecker, Bruce H; Shehata, Bahig M

    2011-01-01

    Nephrogenic adenoma (NA) is a rare lesion of the urinary tract widely considered to be a metaplastic response to urothelial injury. Herein, we present the case of an 8-year-old male with prune belly syndrome who presented with gross hematuria. Investigation revealed a bladder mass; however, upon cystoscopic examination, multiple polypoid lesions were identified. Microscopic examination revealed NA of the bladder. To our knowledge, this is the second reported case of NA of the bladder in association with prune belly syndrome.

  1. Adenoma metanéfrico

    Directory of Open Access Journals (Sweden)

    Ana Sayuri Ota

    Full Text Available Metanephric adenoma is a recently described, rare and benign renal tumor that generally occurs in adults and has an excellent prognosis. Pain, hematuria and palpable mass are the most commonly presented signs. We report the case of a 49-year old female with a 14-cm solitary right renal tumor. Radiological features of the tumor were non-specific and histopathological examination was essential to establish a definitive diagnosis.

  2. Nutcracker syndrome associated with celiacomesentric trunk anomaly: case report

    Directory of Open Access Journals (Sweden)

    Al-Zoubi NA

    2017-12-01

    Full Text Available Nabil A Al-Zoubi,1 Ibrahim F Al-Ghalayini,1,2 Radwan Al-Okour1,2 1Department of Surgery, 2Division of Urology, Jordan University of Science and Technology, Irbid, Jordan Introduction: Nutcracker syndrome is a rare disease entity that is caused by entrapment of the left renal vein between the aorta and superior mesenteric artery, usually due to abnormal branching of the superior mesenteric artery from the aorta causing renal venous hypertension. The symptoms vary from asymptomatic hematuria to severe pelvic congestion. Celiacomesenteric trunk anomaly is a rare variation of splanchnic artery anomaly that occurs when the celiac trunk and superior mesenteric arteries have a common origin from the aorta. A disease involving the rarely encountered celiacomesenteric trunk anomaly is extremely uncommon. To our knowledge, association between nutcracker syndrome and celiacomesentric trunk anomaly has not been reported in the literature.Case presentation: A 14-year-old boy with no significant past medical history presented with a 3-year painless hematuria. CT-angiogram revealed anterior nutcracker syndrome with celiacomesenteric trunk anomaly. The patient was managed conservatively with close follow-up.Conclusion: Nutcracker syndrome associated with celiacomesenteric trunk anomaly is extremely uncommon and is a rare cause of hematuria in children. Whether this abnormal anatomy is the cause of nutcracker syndrome or just an association should be investigated. Moreover, awareness of this anatomical variation may help in planning therapeutic options and reducing the chance of surgical iatrogenic injuries. Keywords: nutcracker syndrome, celiacomesenteric trunk, hematuria in children

  3. DIAGNOSIS AND PATHOLOGICAL IMPORTANCE OF THE DIOCTOPHYMA RENALE

    OpenAIRE

    Gordana Tasic; Nataša Miladinovic-Tasic; Čedo Kutlesic; Aleksandar Tasic; Anđelka svetozarevic-Nikolic; Miloš Stojanovic; Predrag Stojanovic; Suzana Tasic

    2001-01-01

    The aim of the paper is to present an exceptionally rare man's helminth causedby the Dioctophyma renale (DR). This sort is primarily a dog's parasite while in somespecial cases it can be a parasite in man's organism with the most frequent location in the kidney pelvis. The patient appears to have been eaten insufficiently roasted fish.The disease has manifested itself in various symptoms (high body temperature, painsin the back, hematuria and dysuria). The diagnosis was made by histological a...

  4. Dioctophyma renale (Goeze, 1782) Infection in a Domestic Dog from Hamedan, Western Iran

    OpenAIRE

    ZOLHAVARIEH, Seyed Masoud; NORIAN, Alireza; YAVARI, Morteza

    2016-01-01

    Dioctophyma renale infection is found in a wide range of mammalian species, typically in temperate areas of the world. Here, we report for the first time, the parasitism of a domestic dog by D. renale in Hamedan, Iran, a mountainous cold region, lacking significant amounts of rainfall, high humidity and temperature. A 2.5 yr old male mixed breed dog was presented with a two months history of progressive hematuria and muscle weakness. Complete blood count and serum biochemistry were performed ...

  5. Metastatic malignant tumor in native kidney with acquired cystic disease after renal transplantation

    International Nuclear Information System (INIS)

    Garcia de la Oliva, T.; Gonzalez Molina, M.

    1990-01-01

    Patients on long-term hemodialysis frequently develop Acquired Cystic Renal Disease (ARCD). When hematuria or flank pain occurs, the possibility of malignant renal tumors should be investigated. The authors present an ARCD patient who received a kidney transplant and developed malignancy in a native kidney, the first manifestation being bone metastases, and discuss the role of CT in evaluating these patients. (authors). 9 refs.; 2 figs

  6. Water Quality Criteria for White Phosphorus

    Science.gov (United States)

    1987-08-01

    the number of eggs produced per adult , Chronic tests using inidges exposed to elemental phosphorus through contaminated sediments were also performed by...hemoglobinemia, hemoglobinuria, hematuria, bilirubinemia, mild (Cases 2 and 3) to severe (Case 1) hypocalcemia , -61- r. ., TABLE 14. SUMMARY OF CASUALTIES...day yellow phosphorus in corn oil for 30 days or less, lost weight. Young adult rats injected with 0.5 mg/kg/day lost less weight than fully mature or

  7. [Vesical schistosomiasis, case report and Spanish literature review].

    Science.gov (United States)

    Donate Moreno, M J; Pastor Navarro, H; Giménez Bachs, J M; Carrión López, P; Segura Martín, M; Salinas Sánchez, A S; Virseda Rodríguez, J A

    2006-01-01

    Urinary schistosomiasis is an infection caused by parasite, Schistosoma haematobium. Squistosomiasis is an endemic disease in Africa and Middle East. We are presenting a case of a young immigrant male from Mali that came to our clinic with hematuria and miccional irritative syndrome during a year. Parasitological study reported Schimosoma's eggs and ecography showed a possible vesical newformation. After RTU, anatomopatological study confirms the presence of a vesical esquistosomiasis. Now pacient is asyntomatic after he was treated with Praziquantel.

  8. The radiology of abdominal calcification including demonstration of a readily useful and comprehensive classification scheme

    International Nuclear Information System (INIS)

    Baker, S.R.

    1995-01-01

    The analysis of abdominal calcifications and other radiopacities on plain radiographs is often a diagnostic challenge. Occasionally, historical information will be a value; at times, physical examination will contribute important clues. Laboratory date such as the presence of microscopic hematuria will sometimes be helpful. Yet, very frequently, the appearance of the opacity is unexpected. The contents are morphology; concretions; conduit wall, cyst wall, solid mass calcification; mobility; effect of respiration; effect of peristalsis, growth of masses

  9. A case of propylthiouracil-induced antineutrophilic cytoplasmic antibody-positive vasculitis successfully treated with radioactive iodine

    Directory of Open Access Journals (Sweden)

    C. Bes

    2013-07-01

    Full Text Available Antineutrophilic cytoplasmic antibody (ANCA associated vasculitis is one of the rare complications of propylthiouracil treatment. Having a variable clinical spectrum, it may be presented with both skin limited vasculitis and life-threatening systemic vasculitis. In this study, we present a case that developed ANCA-positive vasculitis with skin and kidney involvement (hematuria and proteinuria six months after propylthiouracil treatment was initiated for toxic nodular goiter. Proteinuria recovered dramatically subsequent to radioactive iodine treatment following ceasing the drug.

  10. A Giant Pedunculated Urothelial Polyp Mimicking Bladder Mass in a Child: A Rare Case

    Directory of Open Access Journals (Sweden)

    Mehmet Kaba

    2014-01-01

    Full Text Available Ureteral fibroepithelial polyps are rarely seen benign tumors with mesodermal origin. These polyps can involve kidney, pelvis, ureter, bladder, and urethra. The most common symptoms are hematuria and flank pain. The choice of treatment is either endoscopic or surgical resection of polyp by sparing kidney. Here, we presented a pediatric case with giant, fibroepithelial polyp that mimics bladder tumor, originating from middle segment of the ureter.

  11. A case report of inverted papilloma of the posterior urethra

    OpenAIRE

    徳光, 正行; 井内, 裕満; 森川, 満; 八竹, 直

    1992-01-01

    A case of inverted papilloma of the posterior urethra is reported. A 59-year-old male was admitted with the chief complaint of hematuria. Urethrogram revealed a small defect in the neck of the bladder. Endoscopic examination revealed a polypoid tumor on the stalk arising from prostatic urethra, and transurethral resection was performed. The patient has been subsequently followed up and there has been no evidence of recurrence. Although 141 cases of inverted papilloma have been reported in man...

  12. A case report of inverted papilloma of the posterior urethra

    OpenAIRE

    長谷川, 総一郎; 絹川, 常郎; 松浦, 治; 竹内, 宜久; 服部, 良平; 小野, 佳成; 大島, 伸一; 村上, 榮

    1987-01-01

    Sixty-seven cases of inverted papilloma have been reported in many anatomical sites of urinary tract but only 9 cases involving the posterior urethra have been described in Japan. We report the 10th case of inverted papilloma of the posterior urethra in a 27-year-old male who complained of macroscopic hematuria. The lesion was diagnosed cystoscopically and treated by transurethral resection.

  13. Posterior urethral polyps and review of literature

    Directory of Open Access Journals (Sweden)

    Prashant Jain

    2007-01-01

    Full Text Available Urethral polyp is a rare finding in young children. Fibroepithelial polyps of the urethra are usually diagnosed during the first decade of life. They present with obstruction, voiding dysfunction and hematuria. They can be associated with other congenital urinary tract anomalies. They are usually benign fibroepithelial lesions with no tendency to recur and are treated by surgical ablation, fulguration or laser therapy.

  14. Kidney, Ureteral, and Bladder Cancer: A Primer for the Internist.

    Science.gov (United States)

    Arora, Hans C; Fascelli, Michele; Zhang, Jj H; Isharwal, Sudhir; Campbell, Steven C

    2018-03-01

    Malignancies of the urinary tract (kidney, ureter, and bladder) are distinct clinical entities. Hematuria is a unifying common presenting symptom for these malignancies. Surgical management of localized disease continues to be the mainstay of treatment, and early detection is important in the prognosis of disease. Patients often require life-long follow-up and assessment for recurrence. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Subclinical nephritic syndrome in children cohabiting with pediatric patients, Presenting acute nephritic syndrome

    OpenAIRE

    Guerrero-Tinoco Gustavo Adolfo; Julio-Barrios Emil

    2012-01-01

    Introduction: subclinical nephritic syndrome is the presence of hematuria, hypocomplementemiaand/or proteinuria without the presence of signs and/or symptoms.Objective: to determine the incidence of subclinical nephritic syndrome in childrenliving with pediatric patients diagnosed with acute nephritic syndrome.Methods: family visit to identify children living together in the two previous months, with pediatric patients hospitalized with acute nephritic syndrome, at Hospital InfantilNapoleon F...

  16. Síndrome nefrítico asociado con infección cutánea, hepatitis A y neumonía: informe de un caso

    OpenAIRE

    Barrios, Emil Julio; Guerrero, Gustavo Adolfo

    2010-01-01

    Introduction: Glomerulonephritis is the most common cause of acute and chronic renal disease. The prototype of acute glomerulonephritis is acute post-infectious glomerulonephritis. Recently, increased cases of glomerulopathy have been associated with bacterial, viral, and other infections. Acute nephritic syndrome is part of glomerulonephritis with an acute beginning, characterized by hematuria, hypertension, edema, and oliguria due to the reduction of glomerular filtration reflected in an in...

  17. Ureteroarterial fistula: a case report

    International Nuclear Information System (INIS)

    Kim, Young Sun; Kim, Ji Chang

    2007-01-01

    Ureteroarterial fistula is an extremely rare complication, but is associated with a high mortality rate. Previous pelvic surgery, long standing ureteral catheter insertion, radiation therapy, vascular surgery and vascular pathology contribute the development of this uncommon entity. Herein, a case of ureteroarterial fistula in a 69-year-old female patient, who presented with a massive hematuria, proven in a second attempt at angiography, is reported

  18. Renal Infarction Caused by Spontaneous Renal Artery Dissection: Treatment with Catheter-Directed Thrombolysis and Stenting

    International Nuclear Information System (INIS)

    Jeon, Yong Sun; Cho, Soon Gu; Hong, Ki Cheon

    2009-01-01

    Spontaneous renal artery dissection (SRAD) is rare and presents a diagnostic and therapeutic challenge. We report a case of a 36-year-old man who had an SRAD-complicated renal infarction. The patient experienced severe unilateral flank pain. Enhanced abdominal computed axial tomography scan showed renal infarction, and urinalysis showed no hematuria. Selective renal angiography was essential to evaluate the extent of dissection and suitability for repair. The patient was treated with catheter-directed thrombolysis and frenal artery stenting.

  19. Reduced recurrence of late hemorrhagic radiation cystitis by WF10 therapy in cervical cancer patients

    International Nuclear Information System (INIS)

    Veerasarn, Vutisiri; Khorprasert, Chonlakiet; Lorvidhaya, Vicharn; Sangruchi, Supatra; Tantivatana, Thanatip; Narkwong, Ladawan; Kongthanarat, Yongyut; Chitapanarux, Imjai; Tesavibul, Chanawat; Panichevaluk, Apichart; Puribhat, Sirisak; Sangkittipaiboon, Somphob; Sookpreedee, Lak; Lertsanguansinchai, Prasert; Phromratanapongse, Pramook; Rungpoka, Poonkiat; Trithratipvikul, Supamitr; Lojanapiwat, Bannakij; Ruangdilokrat, Sathit; Ngampanprasert, Pichai

    2004-01-01

    Background and purpose: To evaluate the efficacy and the safety of WF10 as adjunct to standard treatment in the management of late hemorrhagic radiation cystitis compared to standard treatment alone. Patients and methods: Cervical cancer patients with Grade 2 or 3 late hemorrhagic radiation cystitis, were randomized and treated with WF10 0.5 ml/kg body weight, diluted in physiological saline or 5% dextrose water 250 ml, intravenous infusions over 2 h on 5 consecutive days, every 3 weeks for 2 cycles plus standard treatment (WF10 group) or standard treatment alone (control group). Fifty patients in each group were evaluated by questioning; urinalysis and cystoscopy during a 1 year follow up. Results: At week 7, 37 patients (74%) in the WF10 group and 32 patients (64%) in the control group showed complete resolution in objective hematuria (P=0.28). Significantly lower use of antibiotics (P=0.002) and antispasmodics (P<0.001) was found in the WF10 group. Among the responders, 24 patients (77%) in the control group experienced recurrent objective hematuria, whereas in the WF10 group only 17 patients (47%) experienced a recurrence (P=0.01). Recurrence of objective hematuria occurred significantly faster in the control group as evidenced by Kaplan-Meier and log-rank statistics (P=0.004), suggesting a long-term effect of WF10. Cystoscopy, at the end of the treatment period and after the one year follow up showed overall improvement without significant difference between two groups. No severe toxicity was monitored. Conclusions: WF10 therapy is a safe, non-invasive and convenient method in the management of late hemorrhagic radiation cystitis. WF10 therapy, as adjunct to standard treatment, has significantly reduced recurrence of objective hematuria, compared to standard treatment alone, during a one year follow up

  20. Renal Cell Carcinoma of the Kidney with Synchronous Ipsilateral Transitional Cell Carcinoma of the Renal Pelvis

    Directory of Open Access Journals (Sweden)

    Dogan Atilgan

    2013-01-01

    Full Text Available A 73-year-old man was admitted to our clinic with flank pain and gross macroscopic hematuria. Radiologic examination revealed a solid mass in the left kidney and additionally another mass in the ureteropelvic junction of the same kidney with severe hydronephrosis. Left nephroureterectomy with bladder cuff removel was performed, and histopathological evolution showed a Fuhrman grade 3 clear cell type RCC with low-grade TCC of the pelvis.

  1. Medical Surveillance Monthly Report (MSMR). Volume 4, Number 3, April 1998

    Science.gov (United States)

    1998-04-01

    expressed are not necessarily those of the Department of the Army. Surveillance Trends Frequencies, rates and trends of hospitalizations and associated...Army Medical Center lets 33,000), and leukocytosis (WBCs 15.6). Her urinalysis revealed trace protein and hematuria. Serologic tests for IgM and IgG...addition, several cases received intravenous penicillin when they were admitted to TAMC. All cultures were negative for leptospira ; thus, it is

  2. Giant Leiomyosarcoma of the Urinary Bladder.

    Science.gov (United States)

    Ribeiro, José G A; Klojda, Carlos A B; Araújo, Claudio P De; Pires, Lucas A S; Babinski, Marcio A

    2016-05-01

    The bladder leiomyosarcoma is a rare and agressive mesenchymal tumour, and adult women of reproductive age have a higher incidence of developing the bladder leiomyosarcoma. The pathophysiology of the disease is not certain, and its main symptoms are hematuria, dysuria and abdominal pain. There are not a considerable amount of cases described in the literature. We report a case of a giant leiomyosarcoma of the urinary bladder in a 31-year-old woman.

  3. Raising awareness of chronic kidney disease in a Brazilian urban population

    Directory of Open Access Journals (Sweden)

    M. Mazza Nascimento

    2009-08-01

    Full Text Available The incidence and prevalence of chronic kidney disease have been increasing in recent years in developing countries. The aim of this study was to report the results of a general chronic kidney disease awareness program applied to an urban population in a large Brazilian city. From January 2002 to January 2005 a total of 8883 individuals in the city of Curitiba (PR, Brazil were screened for hypertension, body mass index, hematuria, and proteinuria. A family history and previous medical diagnosis of hypertension and diabetes mellitus (DM were also recorded. Of the 8883 individuals assessed, 56% were women, subject median age was 47 years (range: 17-93 years and more than 90% were Caucasian. Thirty percent had signs of hematuria, 6% had proteinuria, and 3% had hematuria and proteinuria. The median of mean arterial pressure values was 93 mmHg (range: 71-135 mmHg and 16% of the population screened had a history of hypertension. A significant positive family history of both hypertension or DM was present in 42% (P < 0.0001; chi-square = 83.18 and 7% (P < 0.0001; chi-square = 161.31 of the hypertensive group, respectively. Finally, the prevalence of hypertension and DM was significantly higher in older individuals with proteinuria. In the present study, a higher prevalence of hematuria and proteinuria was found in older individuals with hypertension and diabetes compared to the general population. These data confirm the need for public awareness of renal disease in high-risk individuals.

  4. The radiology of abdominal calcification including demonstration of a readily useful and comprehensive classification scheme

    Energy Technology Data Exchange (ETDEWEB)

    Baker, S R [University Hospital, Newark, New Jersey (United States)

    1996-12-31

    The analysis of abdominal calcifications and other radiopacities on plain radiographs is often a diagnostic challenge. Occasionally, historical information will be a value; at times, physical examination will contribute important clues. Laboratory date such as the presence of microscopic hematuria will sometimes be helpful. Yet, very frequently, the appearance of the opacity is unexpected. The contents are morphology; concretions; conduit wall, cyst wall, solid mass calcification; mobility; effect of respiration; effect of peristalsis, growth of masses.

  5. Henoch-Schönlein purpura in an older man presenting as rectal bleeding and IgA mesangioproliferative glomerulonephritis: a case report

    OpenAIRE

    Howarth Charles B; Jirajariyavej Teeranun; Cheungpasitporn Wisit; Rosen Raquel M

    2011-01-01

    Abstract Introduction Henoch-Schönlein purpura is the most common systemic vasculitis in children. Typical presentations are palpable purpura, abdominal pain, arthritis, and hematuria. This vasculitic syndrome can present as an uncommon cause of rectal bleeding in older patients. We report a case of an older man with Henoch-Schönlein purpura. He presented with rectal bleeding and acute kidney injury secondary to IgA mesangioproliferative glomerulonephritis. Case presentation A 75-year-old Pol...

  6. Sclerotherapy for a simple renal cyst causing hydronephrosis: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Ji Hun; Park, Sang Woo; Chang, Il Soo; Hwang, Jin Ho; Jung, Sung Il [Dept. Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul (Korea, Republic of)

    2017-05-15

    A simple renal cyst usually remains asymptomatic and requires no invasive treatment. Occasionally, however, some cysts may cause pain, hematuria, hypertension, or obstruction of the collecting system. We describe a case of a 50-year-old man who presented with hydronephrosis caused by an ipsilateral simple renal cyst without any stone or significant mass in the urinary system. The patient was eventually treated successfully with sclerotherapy.

  7. [Could isolated mesangial deposits of C3 be responsible of glomerular hematuric nephropathies (author's transl)].

    Science.gov (United States)

    Saint-Andre, J P; Touzard, D; Houssin, A; Simard, C

    1982-01-01

    This communication presents three cases of prolonged macroscopic hematuria in young subjects. Complementary explorations eliminated urologic or vascular causes. Renal biopsies showed minimal glomerular lesions with light microscopy, normal basement membranes in electron microscopy and mesangial deposits of C3 and properdine in immunofluorescence. Although the mesangial deposits of C3 lack specificity and the number of observations is small, it appears useful to report such cases so as to indicate their frequency and perhaps their autonomy, in glomerular hematuric nephropathies.

  8. Nephrogenic adenoma of the ureter

    Directory of Open Access Journals (Sweden)

    Mustafa Burak Hoscan

    2012-04-01

    Full Text Available Nephrogenic adenoma (NA is an uncommon benign lesion of the urothelial tract. The diagnostic features that are useful in the recognition of this benign entity are: the characteristic mixture of various architectural patterns, associated stromal edema and inflammation, hyaline sheath around tubules, and lack of mitotic activity. Although NA appears with hematuria or obstruction, frequently found incidentally in endoscopy or imaging modalities.

  9. Multiple sclerosis outcome and morbi-mortality of a Brazilian cohort patients Caracteristicas clínico-evolutivas e morbi-mortalidade de uma coorte de pacientes brasileiros com esclerose múltipla

    Directory of Open Access Journals (Sweden)

    Soniza Vieira Alves-Leon

    2008-01-01

    Full Text Available We studied the clinical and evolution characteristics of multiple sclerosis (MS patients followed since the onset of HUCFF/UFRJ in 1978. The diagnosis of MS was based on Poser's et al. and MC Donald's et al. criteria. From 188 patients, 122 were included. Eighty-five were females. The mean age onset was 32.2 years-old (range 6.0 to 61.0±10.3, mainly Caucasians (82/67%. The relapsing-remitting course (MSRR was more frequent (106/86.8%. Monosymptomatic onset was significantly more frequent in Caucasians than in Afro-Brazilians (pEstudamos as características clínico-evolutivas de pacientes com esclerose múltipla (EM acompanhados no HUCFF-UFRJ desde 1978. Foram usados critérios de Poser et al. e MC Donald et al. para o diagnóstico de EM. De 188, 122 foram incluídos. Oitenta e cinco eram mulheres. A média de idade de início foi 32,2 anos (6,0-61,0±10,3, predominando caucasianos (n=82/67%. A forma recorrente-remitente (EMRR foi mais freqüente (n=106/86,8%. Formas mono-sintomáticas no primeiro surto foram significativamente mais freqüentes em caucasianos do que em afro-brasileiros (p<0,05. Dezessete pacientes apresentavam a forma benigna (13,9% e 43 a grave (35,2%. A forma benigna foi associada com a EMRR (p=0,01. A taxa de letalidade 2,12% (4 óbitos. Nossos resultados são semelhantes aos de outras séries brasileiras no que se refere ao sexo e idade, e falta de correlação entre EDSS e número de surtos; confirmamos gradiente sul-sudeste de distribuição afro-descendente, associação significativa entre primeiro surto mono-sintomático e caucasianos e menor freqüência de formas benignas.

  10. Comparación de los efectos del D-004, imipramina y sertralina en el modelo de nado forzado en ratones

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    Daisy Carbajal Quintana

    2012-09-01

    Full Text Available Introducción: La finasterida, inhibidor de la 5 a-reductasa, se emplea en el tratamiento de la hiperplasia prostática benigna, y ocasiona entre sus efectos adversos un aumento de cuadros de depresión. El D-004 es un extracto lipídico extraído a partir del fruto de la palma real (Roystonea regia, inhibe la 5 a-reductasa y previene la hiperplasia prostática benigna, y muestra un efecto antidepresivo moderado en el ensayo de nado forzado y suspensión por la cola. Objetivo: comparar el efecto del D-004 con la imipramina y la sertralina sobre la duración de las conductas de inmovilidad, nado y escalado en el ensayo de nado forzado. Métodos: se distribuyeron los ratones en ocho grupos: control (vehículo, tres tratados con D-004 (100, 250 y 500 mg/kg, dos con sertralina y dos con imipramina (30 y 50 mg/kg respectivamente. Estos se colocaron en un cilindro de cristal que contenía agua a una altura de 6 cm y se cuantificaron las conductas. Resultados: la administración oral de D-004 (100, 250 y 500 mg/kg durante 14 días redujo significativamente el tiempo de inmovilidad con respecto al grupo control (17, 22 y 25 % y aumentó significativamente la conducta de nado en 1,58, 1,68 y 1,74 veces. Este efecto resulta moderado (25 % comparado con las reducciones alcanzadas por la sertralina y la imipramina (³ 60 %. Las dosis mayores (250 y 500 mg/kg ocasionaron incrementos de la conducta de escalado, 2,79 y 3,55 veces superiores a la del grupo control, lo que mostró semejanza con la imipramina, aunque con una menor eficacia. Conclusiones: el D-004 ejerce un moderado efecto antidepresivo, lo que pudiera contribuir al manejo de los pacientes con hiperplasia prostática benigna en los cuales se informa coincidencia de cuadros depresivos.

  11. Papel da criocirurgia no tratamento das neoplasias cutâneas do segmento cabeça e pescoço: análise de 1900 casos

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    Antonio Azoubel Antunes

    Full Text Available OBJETIVO: Demonstrar a experiência dos autores na utilização da criocirurgia como tratamento de lesões benignas e malignas da pele e mucosa no segmento cabeça e pescoço. MÉTODO: Os autores realizam um estudo retrospectivo multicêntrico de 1900 casos de pacientes portadores de neoplasias benignas e malignas da cabeça e do pescoço, atendidos e tratados no Centro de Oncologia do Hospital Universitário Oswaldo Cruz (CEON/HUOC/UPE, Hospital de Câncer de Pernambuco (HCP e clínica privada, no período de abril de 1977 a abril de 2002 (25 anos. Comparam, ainda, os dados obtidos com a revisão bibliográfica realizada, bem como sua experiência pessoal na utilização de tal modalidade terapêutica. RESULTADOS: Do total de pacientes, 57,9% eram do sexo masculino e a quinta e sexta décadas de vida foram as mais frequentemente acometidas (58,9%. O Carcinoma basocelular foi o tipo histológico predominante (63,1% - 1200 casos, seguido dos hemangiomas (14,2% - 270 casos. O tempo médio de exposição das lesões ao nitrogênio líquido foi de 15 e 35 segundos, e o tempo médio de cicatrização de 14 e 21 dias para as lesões benignas e malignas respectivamente. CONCLUSÕES: A indicação da criocirurgia deve obedecer alguns critérios de avaliação como o aspecto macroscópico e tamanho da lesão, tipo histológico, localização, idade e perfil social de cada paciente. Quando indicada e executada corretamente, oferece idênticos índices de cura aos outros métodos terapêuticos convencionais.

  12. Nevus sebáceo de Jadassohn: descripción de 261 casos y su asociación con otros tumores

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    Paula Andrea Arango Pérez

    2008-11-01

    Full Text Available El nevus sebáceo de Jadassohn (NSJ es una lesión congénita benigna pero por decenios se la consideró con alto potencial de malignización hacia el carcinoma basocelular (CBC, por lo que se sugería su resección precoz. Series recientes han establecido que muchas de las neoplasias diagnosticadas como malignas eran benignas. Nuestra revisión de 261 casos constituye un aporte al conocimiento del NSJ. Hasta ahora no ha habido series similares en Colombia, y en América Latina las publicaciones no superan los 60 pacientes. MATERIALES Y MÉTODOS: se analizaron 261 casos del archivo de histopatología de la Facultad de Medicina de la Universidad de Antioquia con diagnóstico de NSJ entre 1976 y 2008, incluyendo biopsias y resecciones. RESULTADOS: de los 261 pacientes, 143 eran hombres (54,8% y 118 mujeres (45,2%; la edad promedio fue de 17,4 años; el NSJ estaba presente al nacimiento en el 90,4%. La localización más frecuente fue en el cuero cabelludo (62,5%. Presentaron tumores asociados 28 pacientes: siringocistadenoma papilífero (SCAP 8 casos (3,1%, tumor del infundíbulo folicular (TIF 5 casos (1,9%. Cuatro casos fueron de CBC (1,5% con edad promedio de 40,7 años. Cuatro de 7 tumores diagnosticados previamente como CBC, fueron reclasificados como TIF. DISCUSIÓN: el SCAP fue el tumor más frecuentemente asociado, tal como aparece reportado por otros autores. En esta serie se encontró el TIF con una mayor frecuencia que en la literatura revisada. El CBC fue el único tumor maligno y se presentó solo en adultos. Los resultados de esta serie evidencian un comportamiento benigno del NSJ, por lo que se debiera replantear la necesidad de resección precoz. La revisión histológica del diagnóstico inicial demuestra que lesiones benignas pueden ser confundidas fácilmente con CBC, sobreestimando el potencial maligno de este hamartoma.

  13. Renal involvement in behcet's disease

    International Nuclear Information System (INIS)

    Ardalan, Mohammad Reza; Noshad, Hamid; Sadreddini, Shahram; Ebrahimi, Aliasghar; Molaeefard, Mahsheed; Somi, Mohammad Hossein; Shoja, Mohammadali Mohajel

    2009-01-01

    There are conflicting reports about the renal involvement in Behcet's disease (BD). In this study we aimed to study the frequency and type of renal involvement in a group of patients with BD in Azerbaijan province that is one of the prevalent areas of BD in Iran. All cases of BD were prospectively followed between June 2004 and January 2007, and evaluated for renal dys-function (serum creatinine > 1.7 mg/dL), glomerular hematuria and proteinuria. Those patients with proteinuria > 500 mg/day and serum creatinine level > 2 mg/dL, underwent renal biopsy. From a total number of 100 patients, six patients (6%) had obvious renal involvements. Four patients had glomerular hematuria and proteinuria. Renal biopsy in two of them revealed measangial proliferative glumerulonephritis with IgA deposit in one of them and membranoproliferative glumerolonephritis in another one. Two remaining patients had serum creatinine > 2 mg/dL without any hematuria or proteinuria. Serologic study for viral agents and collagen vascular disease were negative in all patients with renal involvements. In conclusion, renal involvement in BD is not infrequent, although in most cases it is mild in nature and may be missed. (author)

  14. Complications of bladder distension during retrograde urethrography.

    Science.gov (United States)

    Barsanti, J A; Crowell, W; Losonsky, J; Talkington, F D

    1981-05-01

    A severe, ulcerative cystitis that resulted in macroscopic hematuria occurred in 8 of 20 healthy dogs undergoing a series of diagnostic tests. Four of the remaining 12 dogs had mild bladder lesions consisting of submucosal edema and hemorrhage. Nine of the 20 dogs developed urinary tract infection after the procedures. These complications seemed associated with the radiographic technique of retrograde urethrography performed when the urinary bladder was distended. To test this hypothesis, retrograde urethrography was performed on 5 additional dogs. With the bladder undistended, no complications occurred. However, distention of these same dogs' bladders for 1 minute or less with sterile lactated Ringer's solution administered through a Foley catheter in the penile urethra resulted in a macroscopic hematuria in all 5 dogs which persisted for 24 hours. A microscopic hematuria continued for 5 days. One dog developed a bacterial urinary tract infection. A severe fibrinopurulent cystitis was present at necropsy of 2 dogs 2 days after distention. The morphologic changes in the bladder gradually diminished over 7 days, but mild submucosal edema and hemorrhage were still present when 2 dogs were necropsied, 7 days after distention. These studies indicated that retrograde urethrography in dogs may be complicated by hemorrhagic cystitis and urinary tract infection if performed with urinary bladder distention.

  15. Internal Iliac Artery Embolization for the Control of Severe Bladder Hemorrhage Secondary to Carcinoma: Long-Term Follow-Up

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    Ahmed El-Assmy

    2007-01-01

    Full Text Available The purpose of this study was to evaluate the efficacy and long-term complications of internal iliac artery embolization as a palliative measure in the control of intractable hemorrhage from advanced bladder malignancy. From January 1998 through December 2005, seven patients underwent transcatheter arterial embolization (TAE of anterior division of internal iliac artery bilaterally for intractable bladder hemorrhage. After embolization, patients were followed for the efficacy of the procedure in controlling hematuria and complications. TAE was successful in immediate control of severe hemorrhage in all seven patients after a mean period of 4 days. At a mean (range follow-up of 10 (6–12 months, the hemorrhage was permanently controlled in four (57% patients. Three patients developed hematuria and required emergency admissions; two had mild hematuria and were managed conservatively, and the remaining one required a second attempt of embolization after 2 months from the first one. During the whole period of follow-up, there were no significant complications related to embolization. Internal iliac artery embolization is an effective and minimally invasive option when managing advanced bladder malignancies presenting with intractable bleeding. The long-term follow-up showed control of bleeding in the majority of such patients with no serious complications.

  16. Evaluation of Urinary Inverted Papillomas: A Report of 13 Cases and Literature Review

    Directory of Open Access Journals (Sweden)

    Mete Kilciler

    2008-01-01

    Full Text Available Inverted papilloma (IP of the urothelium accounts for 2.2% of urothelial neoplasms. The aim of this study was to report the results of 13 patients with urinary IP, pointing out the clinical features, presentations, treatment options and outcomes. The mean age and mean follow-up periods of the patients were 60.23+3.25 (range, 44-81 years and 30 (range, 6-42 months, respectively. There was no coexistence of urothelial carcinoma with IP at presentation. Cystoscopy showed a solitary papillary tumor in the bladders of 11 patients and solid pedunculated tumors in the remaining two patients. The site of development was the bladder in 12 cases (92% and ureter in one (8% case. Transurethral bladder tumor resection was performed in 12 cases. For the case with IP in the ureter, nephroureterectomy was performed. Pathologic examination demonstrated that seven of the 13 cases were of the trabecular type and six were of the glandular type. Of the 13 cases, two (7% had recurrence, at 1 year and 1 month and 1 year and 5 months from initial resection. The male to female ratio was 5.5:1. Initial symptoms included macroscopic hematuria in five cases, microscopic hematuria in four, and dysuria and microscopic hematuria in three; one case was asymptomatic. IPs of the urinary bladder are benign tumors that can be treated successfully by transurethral resection and fulguration of the tumor bed. In addition, these lesions must be followed up closely for recurrence and malignant transformation.

  17. Palliative radiotherapy for local progression of hormone refractory stage D2 prostate cancer

    International Nuclear Information System (INIS)

    Kawakami, Satoru; Kawai, Tsuneo; Yonese, Junji; Yamauchi, Tamio; Ishibashi, Keiichiro; Ueda, Tomohiro

    1993-01-01

    From 1970 to 1992, 10 patients with hormone refractory stage D2 adenocarcinoma of the prostate presenting themselves with urinary retention and/or gross hematuria were treated by palliative irradiation for local progression at Cancer Institute Hospital. External beam irradiation was delivered to the primary lesion at dose of 38 Gy to one patient and 30∼27 Gy to seven patients. Five of these patients in whom an urethral catheter had been indwelt were able to void without difficulty following the treatment. Of four patients with severe hematuria resulting from vesical tamponade, none had hematuria after the treatment. These effect lasted until patients' death or more than 11 months follow-up. In other 2 patients, irradiation had to be discontinued at dose less than 20 Gy because of deteriorated general conditions and no significant effect. Complications of the treatment were minimal. These results indicate that the optimal dose of local palliative irradiation is around 30 Gy. Irradiation is a good choice for palliation of locally progressive hormone refactory prostate cancer in view of its certain and long-lasting effect, low invasiveness and minimal complications. When to institute palliative irradiation is one of the most important question in order to secure a good quality of life of patients. From our experiences, it is our belief that if local progression is symptomatic, palliative irradiation should be initiated as soon as possible. (author)

  18. Transcatheter arterial ethanol embolization for congenital renal arteriovenous malformations

    International Nuclear Information System (INIS)

    Wang Jingbing; Wang Han; An Xiao; Wang Linchuan; Gao Liqiang; Zhou Zhiguo; Zhang Guixiang

    2010-01-01

    Objective: To discuss the effect and safety of trans-microcatheter arterial embolization with ethanol for the treatment of congenital renal arteriovenous malformations. Methods: Clinical data of 11 patients with congenital renal arteriovenous malformations manifested mainly as gross hematuria were retrospectively analyzed. Selective renal angiography was performed in all 11 patients. After the diagnosis was confirmed, super-selective catheterization of the diseased arteries was carried out and the trans-microcatheter arterial embolization with ethanol was conducted. Results: A total of 12 procedures were completed in 11 patients. The ethanol dose used in one procedure was 5-25 ml. Successful embolization of the congenital renal arteriovenous malformations was obtained in all patients. The gross hematuria disappeared within 24-48 hours after the treatment. Lumbago at treated side, low fever, abdominal distension, nausea, vomiting, etc. occurred within one week and no other serious complications developed. During the follow-up period lasting for 4-96 months, no recurrence of hematuria was observed and the renal function remained normal. Conclusion: Transcatheter arterial ethanol embolization is an economic, safe and effective treatment for congenital renal arteriovenous malformations. (authors)

  19. Complications and risk factors in transrectal ultrasound-guided prostate biopsies

    Directory of Open Access Journals (Sweden)

    Carlos Márcio Nóbrega de Jesus

    Full Text Available CONTEXT AND OBJECTIVE: Prostate biopsy is not a procedure without risk. There is concern about major complications and which antibiotics are best for routine use before these biopsies. The objective was to determine the rate of complications and the possible risk factors in prostate biopsies. DESIGN AND SETTING: Prospective study, Faculdade de Medicina de Botucatu. METHODS: Transrectal ultrasound (TRUS guided prostate biopsies were carried out in 174 patients presenting either abnormality in digital rectal examinations (DRE or levels higher than 4 ng/ml in prostate-specific antigen (PSA tests, or both. RESULTS: Hemorrhagic complications were the most common (75.3%, while infectious complications occurred in 19% of the cases. Hematuria was the most frequent type (56%. Urinary tract infection (UTI occurred in 16 patients (9.2%. Sepsis was observed in three patients (1.7%. The presence of an indwelling catheter was a risk factor for infectious complications (p < 0.05. Higher numbers of biopsies correlated with hematuria, rectal bleeding and infectious complications (p < 0.05. The other conditions investigated did not correlate with post-biopsy complications. CONCLUSIONS: Post-biopsy complications were mostly self-limiting. The rate of major complications was low, thus showing that TRUS guided prostate biopsy was safe and effective. Higher numbers of fragments taken in biopsies correlated with hematuria, rectal bleeding and infectious complications. An indwelling catheter represented a risk factor for infectious complications. The use of aspirin was not an absolute contraindication for TRUS.

  20. Palliative radiotherapy for local progression of hormone refractory stage D2 prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kawakami, Satoru; Kawai, Tsuneo; Yonese, Junji; Yamauchi, Tamio; Ishibashi, Keiichiro; Ueda, Tomohiro (Japanese Foundation for Cancer Research, Tokyo (Japan). Hospital)

    1993-09-01

    From 1970 to 1992, 10 patients with hormone refractory stage D2 adenocarcinoma of the prostate presenting themselves with urinary retention and/or gross hematuria were treated by palliative irradiation for local progression at Cancer Institute Hospital. External beam irradiation was delivered to the primary lesion at dose of 38 Gy to one patient and 30[approx]27 Gy to seven patients. Five of these patients in whom an urethral catheter had been indwelt were able to void without difficulty following the treatment. Of four patients with severe hematuria resulting from vesical tamponade, none had hematuria after the treatment. These effect lasted until patients' death or more than 11 months follow-up. In other 2 patients, irradiation had to be discontinued at dose less than 20 Gy because of deteriorated general conditions and no significant effect. Complications of the treatment were minimal. These results indicate that the optimal dose of local palliative irradiation is around 30 Gy. Irradiation is a good choice for palliation of locally progressive hormone refactory prostate cancer in view of its certain and long-lasting effect, low invasiveness and minimal complications. When to institute palliative irradiation is one of the most important question in order to secure a good quality of life of patients. From our experiences, it is our belief that if local progression is symptomatic, palliative irradiation should be initiated as soon as possible. (author).

  1. Screening for urine abnormalities among preschool children in western Saudi Arabia

    Science.gov (United States)

    Alharthi, Abdulla A.; Taha, Azza A.; Edrees, Awatif E.; Elnawawy, Ali N.; Abdelrahman, Azza H.

    2014-01-01

    Objectives: To estimate the frequency of urinary problems among preschool children. Methods: In this cross-sectional study, 1000 preschool asymptomatic children attending the outpatient clinics of the Children’s Hospital, Taif, Kingdom of Saudi Arabia between August 2013 and December 2013 were subjected to dipstick urine analysis. Microscopic examination was performed for the abnormal dipstick samples, and children with hematuria were investigated for kidney function. Results: Dipstick urine analysis revealed abnormal findings in 25.1% of the screened children. The most common dipstick abnormalities were positive nitrite test in 18.1%, hematuria in 16.9%, and positive leukocyte esterase test in 14.3% of the cases. The most common abnormality in microscopic urine examination was crystals in 13% of the cases. Pyuria were evident in 5% of cases and hematuria in 2.5%. The most common bacteria in positive urine culture samples was Escherichia coli in 62.6%. Conclusion: In view of these important findings, dipstick screening should be implemented in preschool children. PMID:25491212

  2. Urinary tract infection-like symptom is associated with worse bladder cancer outcomes in the Medicare population: Implications for sex disparities.

    Science.gov (United States)

    Richards, Kyle A; Ham, Sandra; Cohn, Joshua A; Steinberg, Gary D

    2016-01-01

    To determine the time to bladder cancer diagnosis from initial infection-like symptoms and its impact on cancer outcomes. Using Surveillance, Epidemiology and End Results-Medicare, we designed a retrospective cohort study identifying beneficiaries aged ≥ 66 years diagnosed with bladder cancer from 2007 to 2009. Patients were required to have a hematuria or urinary tract infection claim within 1 year of bladder cancer diagnosis (n = 21 216), and have 2 years of prior Medicare data (n = 18 956) without any precedent hematuria, bladder cancer or urinary tract infection claims (n = 12 195). The number of days to bladder cancer diagnosis was measured, as well as the impact of sex and presenting symptom on time to diagnosis, pathology, and oncological outcomes. The mean time to bladder cancer diagnosis was 72.2 days in women versus 58.9 days in men (P urinary tract infection. Cox proportional hazards analysis identified an increased risk of mortality from bladder cancer and all causes in women presenting with urinary tract infection (hazard ratio 1.37, 95% confidence interval 1.10-1.71, and hazard ratio 1.47, 95% confidence interval 1.28-1.69) compared with women with hematuria. Women have a longer interval from urinary tract infection to diagnosis of bladder cancer. Urinary tract infection presentation can adversely affect time to diagnosis, pathology and survival. Time to diagnosis seems not to be an independent predictor of bladder cancer outcomes. © 2015 The Japanese Urological Association.

  3. Renal hemangioma

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    Theodorico F. da Costa Neto

    2004-06-01

    Full Text Available INTRODUCTION: Renal hemangioma is a relatively rare benign tumor, seldom diagnosed as a cause of hematuria. CASE REPORT: A female 40-year old patient presented with continuous gross hematuria, anemia and episodic right lumbar pain, with onset about 3 months previously. The patient underwent multiple blood transfusions during her hospital stay and extensive imaging propedeutics was performed. Semi-rigid ureterorenoscopy evidenced a bleeding focus in the upper calix of the right kidney, with endoscopic treatment being unfeasible. The patient underwent right upper pole nephrectomy and presented a favorable outcome. Histopathological analysis of the surgical specimen showed that it was a renal hemangioma. COMMENTS: Imaging methods usually employed for diagnostic investigation of hematuria do not have good sensitivity for renal hemangioma. However, they are important to exclude the most frequent differential diagnoses. The ureterorenoscopy is the diagnostic method of choice and endoscopic treatment can be feasible when the lesion is accessible and electrocautery or laser are available. We emphasize the open surgical treatment as a therapeutic option upon failure of less invasive methods.

  4. Saccular aneurysm of segmental branch of the main renal artery: approach to diagnosis and treatment

    International Nuclear Information System (INIS)

    Karaman, B.; Hamcan, S.; Bozkurt, Y.; Kara, K.; Aslan, A.

    2012-01-01

    Full text: Introduction: Renal artery aneurysms rarely detected clinical situation. Mostly determined by symptoms such as hematuria, hypertension and flank pain. Generally detected during investigation of symptoms or incidentally. Objectives and tasks: We aim to present the findings of CTA and DSA of the 58-year-old male patient with flank pain, hematuria and hypertension complaints. Materials and methods: We performed CTA and selective renal angiography to 58-year-old male patient with complaints of hypertension, flank pain and hematuria. Results: Approximately 11.5x 13.5 mm size of saccular aneurysm at the upper segmental branch of the left renal artery and focal cortical infarct detected in CT abdomen of the patient before treatment. The aneurysm was confirmed with selective renal angiography examination and treated with Cardiatis stent in the same procedure. Conclusion: Primary goal of treatment of renal artery aneurysms is to prevent complications such as rupture and thrombosis. Renal artery aneurysms have been treated with open surgery previously. Parenchyma preventive and minimally invasive treatments such as Cardiatis stent placement successfully uses currently

  5. Acute Glomerulonephritis: A 7 Years Follow up of Children in Center of Iran

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    Mohsen Akhavan Sepahi

    2011-06-01

    Full Text Available Acute glomerulonephritis (AGN is a type of renal disease which indicates the inflammation of glomerulus and nephrons. This study was carried on 94 children, <15 years old with the diagnosis of AGN who were admitted to Qom and Yazd's hospitals between 2000 and 2006. Data were collected using hospital records on admission, progression notes and outpatient follow up. Among 94 patients, 55.3% were male and 44.6% were female. Mean age of patients was 8.2±2.7 years old. Acute post streptococcal glomerulonephritis (APSGN was reported in 92.5%, membranoproliferative glomerulonephritis in 4.2%, hemolytic uremic syndrome in 2.1% and IgA nephropathy in 1.06%. There was no significant differences between GN types and gender (P=0.54. Clinical manifestation included edema in 68.8%, oliguria in 36.3%, gross hematuria in 69.1%, HTN in 61.7% and anuria in 1.06%. Microscopic hematuria was detected in all patients. In the time of follow up none of patients had hypertension, 3.1% had proteinuria and 6.3% had microscopic hematuria. APSGN is the most common causes of AGN in Qom and Yazd's children. Early diagnosis and treatment of APSGN may protect children from long term morbidity and mortality and improve quality of life.

  6. Mutaciones del gen de la Hemocromatosis en donantes de sangre voluntarios y en pacientes con Porfiria cutánea tarda en Chile Mutations of hemochromatosis gene in volunteer blood donors and Chilean porphyria cutanea tarda patients

    Directory of Open Access Journals (Sweden)

    Carlos Wolff F

    2006-10-01

    Full Text Available La acumulación de hierro hepático asociada a mutaciones en el gen HFE de la hemocromatosis hereditaria (HH en los pacientes con porfiria cutánea tarda (PCT podría tener un papel en la etiología y en la expresión clínica de esta enfermedad. Se estudió la frecuencia de las mutaciones H63D y C282Y en un grupo de pacientes con PCT y se la comparó con la observada en un grupo de donantes voluntarios de sangre. Los pacientes con PCT fueron catalogados como portadores de la forma hereditaria o adquirida de la enfermedad, según presentaran o no mutaciones en el gen uroporfirinógeno decarboxilasa (UROD. El 50% de los pacientes con PCT eran portadores de la forma genética de la enfermedad, porcentaje significativamente mayor que lo informado en otras series. El 23% de los donantes voluntarios de sangre eran portadores de la mutación H63D y 2.4% lo era de la mutación C282Y. Frecuencias similares a lo encontrado por otros autores en población chilena de etnia blanca, en población argentina y española, pero significativamente más alta que lo encontrado en estudios en población aborigen araucana. Esto tiene, probablemente, relación con el predominio de ascendencia española en la población blanca chilena. La frecuencia de mutación en el gen HFE en pacientes con PCT no fue significativamente diferente que la observada en donantes voluntarios de sangre. Tampoco hubo diferencias significativas en la frecuencia de estas mutaciones entre los casos con PCT adquirida respecto de aquellos en que ésta era de origen genético. Los resultados obtenidos no permiten afirmar que exista asociación entre la PCT y la condición de portador de mutaciones del gen HFE de la hemocromatosis hereditaria.In patients with porphyria cutanea tarda (PCT, hepatic iron accumulation associated to hereditary hemochromatosis (HH could play a role in the etiology and in the clinical expression of the disease. The H63D and C282Y mutations of the HFE gene frequency were

  7. Nonoperative management of penetrating kidney injuries: a prospective audit.

    Science.gov (United States)

    Moolman, C; Navsaria, P H; Lazarus, J; Pontin, A; Nicol, A J

    2012-07-01

    The role of nonoperative management for penetrating kidney injuries is unknown. Therefore, we review the management and outcome of penetrating kidney injuries at a center with a high incidence of penetrating trauma. Data from all patients presenting with hematuria and/or kidney injury discovered on imaging or at surgery admitted to the trauma center at Groote Schuur Hospital in Cape Town, South Africa during a 19-month period (January 2007 to July 2008) were prospectively collected and reviewed. These data were analyzed for demographics, injury mechanism, perioperative management, nephrectomy rate and nonoperative success. Patients presenting with hematuria and with an acute abdomen underwent a single shot excretory urogram. Those presenting with hematuria without an indication for laparotomy underwent computerized tomography with contrast material. A total of 92 patients presented with hematuria following penetrating abdominal trauma. There were 75 (80.4%) proven renal injuries. Of the patients 84 were men and the median age was 26 years (range 14 to 51). There were 50 stab wounds and 42 gunshot renal injuries. Imaging modalities included computerized tomography in 60 cases and single shot excretory urography in 18. There were 9 patients brought directly to the operating room without further imaging. A total of 47 patients with 49 proven renal injuries were treated nonoperatively. In this group 4 patients presented with delayed hematuria, of whom 1 had a normal angiogram and 3 underwent successful angioembolization of arteriovenous fistula (2) and false aneurysm (1). All nonoperatively managed renal injuries were successfully treated without surgery. There were 18 nephrectomies performed for uncontrollable bleeding (11), hilar injuries (2) and shattered kidney (3). Post-nephrectomy complications included 1 infected renal bed hematoma requiring percutaneous drainage. Of the injuries found at laparotomy 12 were not explored, 2 were drained and 5 were treated with

  8. Modelling the Impact of Fractionation on Late Urinary Toxicity After Postprostatectomy Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Fiorino, Claudio, E-mail: fiorino.claudio@hsr.it [Department of Medical Physics, San Raffaele Scientific Institute, Milan (Italy); Cozzarini, Cesare [Department of Radiotherapy, San Raffaele Scientific Institute, Milan (Italy); Rancati, Tiziana [Prostate Cancer Program, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan (Italy); Briganti, Alberto [Department of Urology, San Raffaele Scientific Institute, Milan (Italy); Cattaneo, Giovanni Mauro; Mangili, Paola [Department of Medical Physics, San Raffaele Scientific Institute, Milan (Italy); Di Muzio, Nadia Gisella [Department of Radiotherapy, San Raffaele Scientific Institute, Milan (Italy); Calandrino, Riccardo [Department of Medical Physics, San Raffaele Scientific Institute, Milan (Italy)

    2014-12-01

    Purpose: To fit urinary toxicity data of patients treated with postprostatectomy radiation therapy with the linear quadratic (LQ) model with/without introducing a time factor. Methods and Materials: Between 1993 and 2010, 1176 patients were treated with conventional fractionation (1.8 Gy per fraction, median 70.2 Gy, n=929) or hypofractionation (2.35-2.90 Gy per fraction, n=247). Data referred to 2004-2010 (when all schemes were in use, n=563; conventional fractionation: 316; hypofractionation: 247) were fitted as a logit function of biological equivalent dose (BED), according to the LQ model with/without including a time factor γ (fixing α/β = 5 Gy). The 3-year risks of severe urethral stenosis, incontinence, and hematuria were considered as endpoints. Best-fit parameters were derived, and the resulting BEDs were taken in multivariable backward logistic models, including relevant clinical variables, considering the whole population. Results: The 3-year incidences of severe stenosis, incontinence, and hematuria were, respectively, 6.6%, 4.8%, and 3.3% in the group treated in 2004-2010. The best-fitted α/β values were 0.81 Gy and 0.74 Gy for incontinence and hematuria, respectively, with the classic LQ formula. When fixing α/β = 5 Gy, best-fit values for γ were, respectively, 0.66 Gy/d and 0.85 Gy/d. Sensitivity analyses showed reasonable values for γ (0.6-1.0 Gy/d), with comparable goodness of fit for α/β values between 3.5 and 6.5 Gy. Likelihood ratio tests showed that the fits with/without including γ were equivalent. The resulting multivariable backward logistic models in the whole population included BED, pT4, and use of antihypertensives (area under the curve [AUC] = 0.72) for incontinence and BED, pT4, and year of surgery (AUC = 0.80) for hematuria. Stenosis data could not be fitted: a 4-variable model including only clinical factors (acute urinary toxicity, pT4, year of surgery, and use of antihypertensives) was suggested (AUC

  9. Modelling the Impact of Fractionation on Late Urinary Toxicity After Postprostatectomy Radiation Therapy

    International Nuclear Information System (INIS)

    Fiorino, Claudio; Cozzarini, Cesare; Rancati, Tiziana; Briganti, Alberto; Cattaneo, Giovanni Mauro; Mangili, Paola; Di Muzio, Nadia Gisella; Calandrino, Riccardo

    2014-01-01

    Purpose: To fit urinary toxicity data of patients treated with postprostatectomy radiation therapy with the linear quadratic (LQ) model with/without introducing a time factor. Methods and Materials: Between 1993 and 2010, 1176 patients were treated with conventional fractionation (1.8 Gy per fraction, median 70.2 Gy, n=929) or hypofractionation (2.35-2.90 Gy per fraction, n=247). Data referred to 2004-2010 (when all schemes were in use, n=563; conventional fractionation: 316; hypofractionation: 247) were fitted as a logit function of biological equivalent dose (BED), according to the LQ model with/without including a time factor γ (fixing α/β = 5 Gy). The 3-year risks of severe urethral stenosis, incontinence, and hematuria were considered as endpoints. Best-fit parameters were derived, and the resulting BEDs were taken in multivariable backward logistic models, including relevant clinical variables, considering the whole population. Results: The 3-year incidences of severe stenosis, incontinence, and hematuria were, respectively, 6.6%, 4.8%, and 3.3% in the group treated in 2004-2010. The best-fitted α/β values were 0.81 Gy and 0.74 Gy for incontinence and hematuria, respectively, with the classic LQ formula. When fixing α/β = 5 Gy, best-fit values for γ were, respectively, 0.66 Gy/d and 0.85 Gy/d. Sensitivity analyses showed reasonable values for γ (0.6-1.0 Gy/d), with comparable goodness of fit for α/β values between 3.5 and 6.5 Gy. Likelihood ratio tests showed that the fits with/without including γ were equivalent. The resulting multivariable backward logistic models in the whole population included BED, pT4, and use of antihypertensives (area under the curve [AUC] = 0.72) for incontinence and BED, pT4, and year of surgery (AUC = 0.80) for hematuria. Stenosis data could not be fitted: a 4-variable model including only clinical factors (acute urinary toxicity, pT4, year of surgery, and use of antihypertensives) was suggested (AUC

  10. Hemorrhagic cystitis in a patient receiving conventional doses of dacarbazine for metastatic malignant melanoma: case report and review of the literature.

    Science.gov (United States)

    Mohammadianpanah, Mohammad; Shirazi, Mehdi; Mosalaei, Ahmad; Omidvari, Shapour; Ahmadloo, Niloofar

    2007-06-01

    Hemorrhagic cystitis is a potentially life-threatening complication in patients receiving cancer therapy. This urologic emergency is commonly associated with the chemotherapeutic use of oxazaphosphorine alkylating agents. This report describes a case of hemorrhagic cystitis associated with dacarbazine treatment. A 63-year-old man with asymptomatic metastatic malignant melanoma received 3 cycles of dacarbazine (600-850 mg/m2) monochemotherapy, each 3 weeks apart. Two weeks after the third cycle, he presented with gross hematuria and mild dysuria. Physical examination revealed no significant finding. Hematuria was confirmed by urinalysis, and urinary infection was excluded by repeated urine cultures. Ultrasonography revealed diffuse bladder wall thickening with no discrete mass or ulceration. Cystoscopy findings revealed generalized inflammation and edema of the mucosa of the bladder, confirming the diagnosis of hemorrhagic cystitis. The patient's gross hematuria continued for 2 weeks and then completely resolved with supportive care. Two weeks after complete resolution, the patient experienced 2 transient episodes of gross hematuria that lasted a few hours and subsided spontaneously. Dacarbazine is currently considered the standard first-line treatment in patients with advanced malignant melanoma. At standard prescribed doses (a single dose of 850-1000 mg/m2 or 250 mg/m2 for 5 days per cycle), dacarbazine is a reasonably well tolerated chemotherapeutic drug; nausea, vomiting, and myelosuppression are the most common adverse effects. Association of dacarbazine with hemorrhagic cystitis has not been reported previously (in a PubMed literature search from 1950-2006), and only 1 case report associates temozolomide (an analog of dacarbazine) with hemorrhagic cystitis. Based on the Naranjo adverse drug reactions probability scale, an objective assessment revealed dacarbazine to be a probable cause of hemorrhagic cystitis in this case. This case report suggests that

  11. Social Awareness on Early Diagnosis and Treatment of Bladder Cancer: Importance of Age and Education

    Directory of Open Access Journals (Sweden)

    Doğan Değer

    2017-03-01

    Full Text Available Objective: We aimed to evaluate the recognition level of bladder cancer in the society by conducting a survey with regards to social awareness in early diagnosis of bladder cancer in this study. Materials and Methods: The survey was conducted on 100 randomly selected patients who were admitted to our clinic in May 2016 for any complaints. In the survey, the main focus was hematuria which is the first and the most common symptom of bladder cancer and questions and statements on this subject was used. Results: Of 100 patients, 67 (66.7% were male, and 33 (33.3% were female. Thirty six of the patients were younger than 50 (36%, and 64 of them (64% were 50 years and older. Education level of 40 (40% patients was found to be university level, and 60 (60% patients we high school graduates or lower. Twenty seven (27% patients had complains about blood in the urine, while 67 (67% of them had no such complaint. Of 27 patients that had complaint about hematuria, which is the most important symptom of bladder cancer 22 (81% were male and 5 (19% were female. We divided the patients into two groups based on 50 age limit. Group 1 included patients who were below 50, while the group 2 consisted of patients who were 50 years old and above. The rates of immediate consultation were determined to be significantly higher in group 2 than group 1. The rate of consulting urology department in the presence of hematuria, and the rates of considering the risk of bladder cancer as a possible diagnosis were higher in group 2, but the difference was not statistically significant. There was no significant difference found between the two groups who were separated by age in terms of required diagnostic tests. The patients were divided into two more groups based on their education level. Group 3 included patients of university graduates, and group 4 included patients with high school graduates or lower. The rates of immediate consultation were significantly higher in group 4

  12. Oral tumors in dogs: clinical aspects, exfoliative cytology and histopathology Neoplasias orais em cães: avaliação dos aspectos clínicos, histopatologia e citologia esfoliativa

    Directory of Open Access Journals (Sweden)

    Cláudia Ronca Felizzola

    1999-09-01

    Full Text Available In order to establish the diagnosis and prognosis of tumors of the oral cavity, a comparative study was carried out in 130 dogs considering age, sex, breed, clinical aspects, exfoliative cytology as well as histopathology. Exfoliative cytology revealed: 100% negative for benign non-odontogenic tumors, 97.91% negative benign odontogenic tumors and 77.92% positive for malignant tumors. Histopathology showed: 59.23% malignant tumors (33.08% malignant melanoma, 9.23% squamous cell carcinoma, 5.38% osteosarcoma, 2.31% fibrosarcoma, 2.31% angiosarcoma, 1.54% malignant mesenchymal tumors, 1.54% malignant fibrohistiocytoma, 1.54% lymphoma, 0.77% leyomyosarcoma, 0.77%% epithelioid sarcoma and 0.77% angiofibrosarcoma; 36.92% benign odontogenic tumors (25.38% peripheral odontogenic fibroma, 10.0% ossifyng fibroma and 1.54% odontoma in addition to 3.85% benign non-odontogenic tumors (1.54% fibroma, 0.77% plasmocytoma, 0.77% pilomatrixoma and 0.77% giant tumor cells. These results permit us to conclude that exfoliative cytology was an efficient, safe, quick and noninvasive method and could be used for early evaluation of oral cancer.Objetivou-se o estudo comparativo em tumores de cavidade bucal de animais de espécie canina de acordo com sexo, faixa etária, raça, aspectos clínicos, citologia esfoliativa e histopatologia, para estabelecer diagnóstico dessas neoplasias, tendo sido utilizados 130 cães, encaminhados ao Hospital Veterinário (HOVET da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo. Os resultados obtidos na citologia esfoliativa foram: 100% de negativos para neoplasias benignas não odontogênicas; 97,91% de negativos para neoplasias benignas odontôgenicas e 77,92% de positivos para neoplasias malignas. Obtiveram-se os seguintes resultados no exame histopatológico: neoplasias malignas - 59,23% (melanoma 33,08%, carcinoma epidermóide 9,23%, osteossarcoma 5,38%, fibrossarcoma 2,31%, angiossarcoma 2

  13. Paralisis de Bell: Parálisis Facial Idiopática

    OpenAIRE

    González H, José María

    2001-01-01

    La Parálisis de Bell, es una enfermedad benigna de la porción infratemporal del nervio facial, que consiste en la pérdida temporal de la función contráctil de la musculatura mímica de la cara, de causa desconocida, pero puede ser secundaria a un traumatismo, compresión o tumor. Este es un proceso autolimitante que no amenaza la vida del paciente y generalmente desaparece en un plazo de 1 a 3 semanas. Su rango de incidencia es de 23 por cada 100.000 personas por año. Esta alteración no tiene d...

  14. Mucocele del seno maxilar post-traumático Post-traumatic mucocele of the maxillary sinus

    Directory of Open Access Journals (Sweden)

    E. Charro-Huerga

    2009-02-01

    Full Text Available Los mucoceles de los senos paranasales son lesiones benignas pero con un considerable potencial destructivo por la reabsorción ósea que pueden generar. La localización en el seno maxilar es muy poco frecuente así como el origen postraumático. Presentamos el caso de un mucocele de seno maxilar tras 28 años después de un traumatismo facial. Analizamos la etiopatogenia, el diagnóstico y el tratamiento de este tipo de lesiones.Mucoceles of the paranasal sinuses are benign lesions but they can be destructive because they cause bone resorption. The location in a maxillary sinus and a traumatic origin are uncommon. We report a case of mucocele of the maxillary sinus 28 years after facial trauma. We analyzed the etiopathogenesis, diagnosis, and treatment of this type of lesions.

  15. Mortalidad asociada a infección por el virus de Chikungunya

    Directory of Open Access Journals (Sweden)

    Diego Viasus

    2015-01-01

    Full Text Available La infección por el virus de Chikungunya presenta manifestaciones clínicas típicas: fiebre, erupción cutánea y artralgia. La enfermedad es generalmente autolimitada y de evolución benigna. Las complicaciones graves y la muerte ocurren en raras ocasiones y en pacientes con factores de riesgo, principalmente en aquellos con comorbilidades o que se encuentran en edades extremas de la vida. En este artículo describimos un paciente, sin comorbilidades previas conocidas, con infección por el virus de Chickungunya que progresó rápidamente a disfunción orgánica múltiple y murió luego de 36 horas de su ingreso. Este caso ilustra la dificultad del diagnóstico y el tratamiento de la infección grave por el virus de Chikungunya.

  16. Prolapso de gordura orbitária bilateral associado a pterígio: relato de caso Bilateral orbital fat prolapse associated with pterygium: case report

    Directory of Open Access Journals (Sweden)

    Vanderson Glerian Dias

    2006-06-01

    Full Text Available O prolapso de gordura orbitária é entidade benigna incomum que pode causar defeitos estéticos. Os autores apresentam uma paciente de 63 anos com prolapso de gordura orbitária temporal bilateral associado a pterígio medial bilateral, ressaltando aspectos clínicos e cirúrgicos. Discute-se a importância do diagnóstico clínico e de imagem, além da comprovação histopatológica da lesão.Orbital fat prolapse is an uncommon benign entity that can cause esthetic defects. The authors present a 63-year-old patient with bilateral temporal orbital fat prolapse associated with a bilateral nasal pterygium. Clinical and surgical features are described. The clinical, imaging and histopathological diagnoses are discussed.

  17. Displasia fibrosa craneofacial avanzada: a propósito de un caso

    Directory of Open Access Journals (Sweden)

    Natalia Ventura-Martínez

    2014-01-01

    Full Text Available La displasia fibrosa (DF es una enfermedad fibroósea benigna que consiste en el reemplazamiento de hueso normal con excesiva proliferación de tejido conectivo fibroso con estructuras óseas afuncionales. La forma de DF craneofacial es poco frecuente y no está bien definida. La afectación más frecuente en el área craneofacial se da en el cuerpo de la mandíbula y zona posterior del maxilar. Los autores describen el manejo completo y la rehabilitación funcional de un caso de displasia fibrosa de mandíbula avanzado y revisan las opciones terapéuticas de esta condición.

  18. Evolução branda de recidiva de infecção por varicela zoster após tratamento com fingolimode em paciente com esclerose múltipla: relato de casoBenign evolution of shingles with fingolimod in a patient with multiple sclerosis: case report

    Directory of Open Access Journals (Sweden)

    Antonio Arlindo Morais

    2016-03-01

    Full Text Available Objetivo: Relatar o caso de um paciente com recidiva de herpes-zoster (HZ e evolução benigna mesmo diante de imunomodulação para esclerose múltipla (EM. Descrição de caso: Mulher de 48 anos com história de EM durante seis anos, previamente tratada com interferon1b, iniciou tratamento com fingolimode, desenvolvendo HZ após 10 meses de tratamento. Mesmo sem tratamento com acyclovir, a paciente desenvolveu um curso brando, sem posterior desenvolvimento de neuralgia pós-herpética. Conclusões: As novas terapias para EM podem estar associadas a novos tipos de eventos adversos. Apesar da potencial gravidade, nem todos os pacientes com HZ em uso das novas terapias para EM têm curso desfavorável, sendo necessários estudos para identificar fatores de risco para as formas graves.

  19. Cisto dentígero: relação entre imagem radiográfica do espaço pericoronário e laudo histopatológico em terceiros molares inclusos

    OpenAIRE

    Marileia Alves; Karen Corrêa de Oliveira

    2015-01-01

    Justificativa: O Cisto Dentígero é uma patologia benigna que se origina pela separação do folículo da coroa de um dente incluso, sendo o tipo mais comum de cisto odontogênico de desenvolvimento. Objetivo: O objetivo deste trabalho foi verificar a relação entre o espaço pericoronário e laudo histopatológico, através de exames radiográficos e histopatológicos dos folículos no diagnóstico de cisto dentígero em terceiros molares inclusos, de pacientes do Curso de Atualização em Cirurgia Oral Meno...

  20. Genotipagem de HPV e imunorreatividade da ciclina D1 em adenocarcinoma de colo do útero

    OpenAIRE

    Back, Simony dos Reis Segovia da Silva [UNESP

    2013-01-01

    A incidência do adenocarcinoma do colo do útero (AC) está aumentando em muitos países. A associação entre a infecção pelo Papillomavirus Humano (HPV) e o AC ainda permanece incerta. A imunoistoquímica pode auxiliar no diagnóstico nos casos duvidosos, pois algumas condições benignas reativas podem mimetizar processos neoplásicos. Marcadores como bcl-2, Ki-67 e proteína p16INK4A (p16) já foram descritos para ajudar nas dúvidas relacionadas ao epitélio glandular cervical. Trabalhos recentes demo...

  1. Quiste óseo aneurismático mandibular de tipo sólido Mandibular solid aneurysmal bone cyst

    OpenAIRE

    Marta Saldaña Rodríguez; Maria Fe García Reija; Belén García-Montesinos Perea; Marta Mayorga Fernández; Ramón Carlos Saiz Bustillo

    2013-01-01

    El quiste óseo aneurismático sólido es una lesión ósea benigna muy infrecuente de la que no existe consenso en relación a su origen etiopatogénico. Presenta características clínicas, radiológicas e histológicas inespecíficas, por lo que los estudios ultraestructurales son fundamentales para su diagnóstico y clasificación. El diagnóstico diferencial es extenso e incluye múltiples lesiones óseas como el granuloma reparativo de células gigantes e incluso tumores malignos como el osteosarcoma. El...

  2. Anatomía Quirúrgica y Radiológica del Hígado. Fundamentos para las Resecciones Hepáticas

    OpenAIRE

    Manterola, Carlos; del-Sol, Mariano; Ottone, Nicolás; Otzen, Tamara

    2017-01-01

    RESUMEN: El hígado es un órgano sólido, de gran relevancia para la fisiología. Es asiento potencial de lesiones tumorales quísticas y sólidas; benignas y malignas (primarias y secundarias); razón por la cual, conocer su anatomía radiológica y quirúrgica es muy relevante. Los antecedentes históricos comienzan con Berta en 1716, quien fue el primero en realizar una resección hepática; en 1888, Lagenbuch fue el primero el realizar una resección hepática programada. En 1889, Keen realizó la prime...

  3. Niveles de zinc en líquido prostático de pacientes con patologías de próstata

    OpenAIRE

    Gómez, Yenny; Arocha, Francisco; Espinoza, Fabiola; Fernández, Denny; Vásquez, Aracelis; Granadillo, Víctor

    2007-01-01

    La próstata es una glándula que rodea la uretra posterior en el hombre, junto a las vesículas seminales, produce los líquidos prostático y seminal. La prostatitis, la hiperplasia benigna y el cáncer de próstata son las patologías más frecuentes que la afectan. El zinc es un elemento importante en la composición química del líquido prostático y juega un papel fundamental en la inmunología de los fenómenos infecciosos y neoplásicos. El objetivo de la presente investigación fue determinar las co...

  4. Episclerite e esclerite

    OpenAIRE

    Urbano, Andréia Peltier; Urbano, Alessandra Peltier; Urbano, Ivan; Kara, José Newton

    2002-01-01

    p.591-598 As doenças mais freqüentes da esclera são de caráter inflamatório, sendo divididas em episclerite e esclerite. A episclerite é doença benigna, autolimitada, com inflamação do tecido episcleral superficial, ao passo que a esclerite é doença grave, progressiva, com inflamação dos tecidos episcleral superficial, profundo e escleral. A associação da episclerite e esclerite com doenças sistêmicas reumatológicas requer investigação sistêmica dos pacientes com inflamação escleral....

  5. Episclerite e esclerite

    OpenAIRE

    Urbano,Andréia Peltier; Urbano,Alessandra Peltier; Urbano,Ivan; Kara-José,Newton

    2002-01-01

    As doenças mais freqüentes da esclera são de caráter inflamatório, sendo divididas em episclerite e esclerite. A episclerite é doença benigna, autolimitada, com inflamação do tecido episcleral superficial, ao passo que a esclerite é doença grave, progressiva, com inflamação dos tecidos episcleral superficial, profundo e escleral. A associação da episclerite e esclerite com doenças sistêmicas reumatológicas requer investigação sistêmica dos pacientes com inflamação escleral....

  6. Hiperplasia epitelial focal. Tratamiento conservador con ácido tricloroacético: Conservative treatment with trichloroacetic acid

    OpenAIRE

    Harris Ricardo, Jonathan; Vásquez Sanjuán, Katherine; Fortich Mesa, Natalia

    2011-01-01

    La hiperplasia epitelial focal conocida también como enfermedad de Heck es una patología benigna que se caracteriza por la presencia de múltiples pápulas en la mucosa de la cavidad bucal, producida por el virus del papiloma humano afectando principalmente niños y adolescentes. Se reporta caso clínico de paciente femenina de 7 años de edad, remitida por odontopediatría al servicio de estomatología y cirugía oral, por presentar múltiples pápulas en mucosa bucal, de tamaño variable, asintomática...

  7. Nuevos Miembros, Palabras del Académico José Félix Patiño Restrepo.

    Directory of Open Access Journals (Sweden)

    Jose Felix Patiño Restrepo

    2004-03-01

    Son numerosas las contribuciones de Quintero a la cirugía biliar. Una de especial significación es el manejo quirúrgico de las estenosis biliares benignas con la técnica de hepático-yeyunostomía en Y de Roux con asa subcutánea, descrita por Hao-Hui Chen. Con laboriosidad y gran honestidad intelectual, Quintero rescató para este autor del Colegio Médico de Pekín el debido crédito. Su serie de 75 casos operados con excelente resultado es una de las mayores en América Latina y tal vez en el mundo...

  8. Tumor de corpo carotídeo (paraganglioma: relato de dois casos submetidos a tratamento cirúrgico

    Directory of Open Access Journals (Sweden)

    Nelson Mesquita Junior

    Full Text Available Resumo O tumor de corpo carotídeo é uma neoplasia rara, geralmente benigna, que acomete, sobretudo, indivíduos entre a quarta e a quinta décadas de vida. Manifesta-se pela presença de massa cervical consistente localizada abaixo do ângulo da mandíbula, pulsátil e comumente indolor. Pode evoluir para dor local, disfagia, soluços, rouquidão e síndrome do corpo carotídeo hipersensível. Este artigo relata os casos de duas pacientes diagnosticadas com essa neoplasia e submetidas ao tratamento cirúrgico. A primeira foi submetida a uma ressecção em bloco do tumor, enquanto a segunda, com estadiamento mais precoce, foi tratada com uma ressecção subadventicial da lesão.

  9. Cancer de la próstata

    OpenAIRE

    Mendoza, Lupi Alejandro; Fundación Valle de Lili; Gutierrez, María Carolina; López Cardona, Arturo

    1997-01-01

    ¿Qué es la próstata?/¿Qué es la hiperplasia benigna de próstata?/El cáncer de próstata/¿Se hereda el cáncer de próstata?/¿Cómo se presenta y hacia donde se disemina el cáncer de próstata?/¿Cómo de descubre el cáncer de próstata?/¿Qué estudia la ultrasonografía transrectal o ecografía a través de recto?/¿Cómo se analizan los niveles de PSA?/¿Cómo se clasifica el cáncer de próstata?¿Cómo se determina la terapia más adecuada para un cáncer de próstata?/¿Cuáles son las opciones de tratamiento par...

  10. CONHECER PARA TRANQUILIZAR – SÍNDROMA DE BUSCHKE OLLENDORFF, CASO CLÍNICO

    Directory of Open Access Journals (Sweden)

    Isabel Ayres Pereira

    2016-07-01

    Comentários: O SBO tem uma penetrância e expressão fenotípica variáveis, estando descritos casos de lesões cutâneas e ósseas isoladamente. A osteopoiquilose é progressiva e mais evidente a partir da puberdade, e a dor óssea está descrita em apenas 25% dos casos e é habitualmente ligeira. Esta é uma entidade benigna sem sequelas a longo prazo, e o seu conheci- mento e suspeição são fulcrais para o diagnóstico precoce permitindo tranquilizar a família e evitar investigações dispendiosas e desnecessárias.

  11. Exposición espontánea de un torus palatino de la línea media

    OpenAIRE

    Gustavo Sinisterra; Jaime Álvarez; Pablo Emilio Molano

    2013-01-01

    Introducción. El torus, o rodete, palatino es una alteración ósea benigna que puede generar molestias en la fonación y en la deglución. Cuando su crecimiento o exposición persistente producen síntomas molestos, debe ser resecado quirúrgicamente. Presentación del caso. Se trata de una paciente de 82 años de edad, que consultó por una lesión ulcerativa de un año de evolución, que producía dolor, halitosis y molestia a la deglución. En el examen físico de la cavidad oral, se observó una...

  12. Queratosis seborreica de la conjuntiva: informe de un caso

    OpenAIRE

    Gulias-Cañizo, R.; Aranda-Rábago, J.; Rodríguez-Reyes, A.A.

    2006-01-01

    Caso clínico: Las lesiones conjuntivales pigmentadas representan un reto diagnóstico para el clínico. Hombre de 37 años de edad quien presentó una masa conjuntival pigmentada en su ojo derecho. Clínicamente se diagnosticó como melanoma, por lo que se realizó escisión completa del tumor. El diagnóstico histopatológico fue de queratosis seborreica. Discusión: La queratosis seborreica es una lesión benigna que se presenta en los párpados y en la cara de individuos de edad media y adultos mayores...

  13. Estado actual de la cirugía laparoscópica esofágica The present state of esophageal laparoscopic surgery

    OpenAIRE

    F. M. Martínez Regueira; F. Rotellar; J. Baixauli; V. Valentí; A. Gil; J. L. Hernández-Lizoain

    2005-01-01

    La cirugía laparoscópica ha cambiado el abordaje terapéutico de las enfermedades esofágicas más frecuentes. Con los excelentes resultados en el control de síntomas y con la baja morbilidad asociada el tratamiento quirúrgico se indica cada vez más en la patología esofágica benigna como una alternativa superior a un tratamiento médico crónico y menos eficaz. Para la hernia de hiato y el reflujo gastroesofágico la funduplicatura de Nissen por laparoscopia es la técnica de elección. Los mejores r...

  14. Synchronous subungual glomus tumors in the same finger Tumores glômicos subungueais sincrônicos no mesmo dedo

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    Nilton Di Chiacchio

    2012-06-01

    Full Text Available The glomus tumor is an uncommon benign neoplasm of glomus cells. In the majority of the cases it is presented as a solitary painful papule in the subungual region. We report a rare case of a patient with two individual synchronous glomus tumors under the nail bed of the same finger.O tumor glômico é uma neoplasia benigna de células glômicas. Na maioria dos casos se apresenta como uma pápula solitária dolorosa na região subungueal. Relatamos o caso raro de um paciente com dois tumores glômicos sincrônicos sob o leito ungueal do mesmo dedo.

  15. Duplicação [TA] na região promotora do gene UGT1A1 : revisão sistemática e meta - análise

    OpenAIRE

    Monteiro, Susana Cristina Fidalgo

    2012-01-01

    O Síndroma de Gilbert (SG) é uma entidade clínica comum caracterizada por uma forma benigna de hiperbilirrubinemia não conjugada, na ausência de disfunção hepática e de hemólise. O seu diagnóstico, inicialmente de carácter presuntivo, passou a dispor de caracterização molecular quando, em 1995, foram descritas as primeiras mutações no gene UridinoDifosfato-glucuronosil transferase-1 (UGT1A1). Em particular, uma duplicação de 2 nucleotídeos [TA] na região promotora do gene, que tem vindo a rev...

  16. Testagem do 1 - beta - D - Ribofuranosil, 1.2.4 - triazole - 3 - carboxamide em pacientes com hepatite

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    Anastácio Ferreira Morgado

    1976-02-01

    Full Text Available Realizou-se estudo do tipo duplo anonimato em 18 pacientes com hepatite aguda benigna. O gruoo experimental foi testado com uma provável droga de ação antiviral: 1-BETA-D-RIBOFURANOSIL, 1,2,4-TRIAZOLE-3- CARBOXAMIDE. O grupo controle ingeriu um placebo de lactose. Teve-se especial cuidado na seleção de pacientes, incluindo apenas pacientes que preenchessem critérios bem estabelecidos. Os pacientes foram seguidos semanalmente, avaliando-os clínica e laboratorialmente. Os resultados não evidenciaram diferenças significativas entre os dois grupos, sugerindo-se estudos com casuística mais numerosa e em regime de internação hospitalar.

  17. Adrenalectomía laparoscópica

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    José De Vinatea

    2005-12-01

    Full Text Available Objetivo: Evaluar la efectividad y resultados de la adrenalectomía laparoscópica en la patología adrenal benigna. Materiales y Métodos: Estudio retrospectivo de 15 adrenalectomías realizadas en 13 pacientes por el mismo equipo quirúrgico en el Hospital Nacional Guillermo Almenara Irigoyen EsSalud y en la Clínica San Pablo,. Lima - Perú, entre 1996 y 2005, evaluándose la efectividad y resultados con respecto al tamaño del tumor, técnica quirúrgica y otros aspectos. Resultados: Once adrenalectomías fueron unilaterales y dos bilaterales. Las indicaciones fueron: adenoma no funcionante (2, adenoma funcionante (6, feocromocitoma (3, teratoma (1, leiomiosarcoma (1, mielolipoma (2. No hubo mortalidad ni reoperaciones. Conclusión: La adrenalectomía laparoscópica es factible y segura para tumores menores de 7 cm.

  18. Maca (Lepidium meyenii Walp, una revisión sobre sus propiedades biológicas

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    Gustavo F Gonzales

    Full Text Available La maca (Lepidium meyenii es una planta que crece sobre los 4000 metros de altitud en los Andes Centrales del Perú, presenta diferentes variedades de acuerdo al color de su hipocótilo. La presente revisión resume los resultados de estudios sobre los efectos de la maca en la función sexual, la espermatogénesis, la función reproductiva femenina, la memoria, la depresión y la ansiedad, como energizante y contra la hiperplasia benigna de próstata, osteoporosis y síndrome metabólico. Se discute también su efecto antienvejecimiento y la seguridad en su consumo. Se han demostrado diferencias en el efecto de las variedades negra, amarilla y roja de maca. La maca negra es la que mejores resultados presenta sobre la espermatogénesis, la memoria y contra la fatiga, mientras que la maca roja es la variedad que mejor revierte la hiperplasia benigna de próstata y la osteoporosis inducida experimentalmente. Además, la maca reduce los niveles de glucosa, y su consumo se relaciona con la reducción de la presión arterial y un mejor puntaje de salud. Estudios experimentales han demostrado que el consumo a corto como a largo plazo no muestra toxicidad tanto in vivo como in vitro. A pesar que los estudios experimentales han demostrado que la maca presenta diversos efectos benéficos, son necesarios más estudios clínicos para confirmar estos resultados

  19. Aspectos ultrassonográficos e citopatológicos das prostatopatias em 52 cães

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Cunha Lacreta Junior

    2011-10-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2012v25n1p137Neste estudo foram avaliados 52 cães, machos, inteiros, de idades e raças diferentes, além de cães sem raça definida, apresentando sinais clínicos sugestivos de doença prostática. Todos os animais foram submetidos a exames ultrassonográfico e punção aspirativa da glândula prostática para avaliação citológica. A hiperplasia prostática benigna (HPB foi a prostatopatia mais frequente, seguida pela hiperplasia prostática benigna cística, prostatite bacteriana, abscesso, cisto, adenocarcinoma, prostatite não bacteriana e cisto paraprostático. Depois dos cães sem raça definida, os da raça Poodle e Pastor alemão foram os que apresentaram maior frequência das afecções prostáticas. O exame ultrassonográfico permitiu a determinação das dimensões prostáticas, bem como a visibilização dos aspectos das enfermidades que acometem a glândula e foi efetivo na orientação da punção aspirativa. A avaliação citológica da glândula, principalmente quando associada às alterações das imagens ultrassonográficas, permitiu determinar o diagnóstico presuntivo da afecção.

  20. ¿Migraña o epilepsia? Cómo identificar y diferenciar las epilepsias occipitales

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    Andrés Castaño Parra

    2005-02-01

    Full Text Available Las epilepsias focales idiopáticas de la infancia constituyen el 30-35% de todas las epilepsias en el rango de edad de 2 a 10 años. La más frecuente de todas es la epilepsia benigna de la infancia con espigas centrotemporales, denominada también Rolándica. En segundo lugar se encuentran las epilepsias occipitales que, aunque son relativamente infrecuentes, se deben conocer para hacer el diagnóstico y diferenciarlas de otras entidades más frecuentes como la migraña con aura. Entre las epilepsias occipitales se deben diferenciar las formas .sintomáticas. (que tienen causas conocidas de las idiopáticas (genéticas. En las primeras se logra demostrar una lesión estructural en el sistema nervioso central (SNC que puede explicar la epilepsia. Las epilepsias idiopáticas occipitales benignas de la infancia se dividen de acuerdo con la edad de inicio, el cual puede ser temprano, conocida también como tipo Panayiotopoulos, o tardío, también denominada tipo Gastaut. Hay una tercera forma de epilepsia idiopática aún no aceptada por muchos autores, la cual es una combinación de las dos anteriores, con un patrón electroencefalográfico específico. La migraña con aura presenta algunas características que permiten al clínico diferenciarla de las epilepsias occipitales.

  1. La displasia cemento ósea florida y su diagnóstico diferencial

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    Allan Ulisses Carvalho de Melo

    2011-09-01

    Full Text Available Las lesiones benignas fibro-óseas de los maxilares constituyen un grupo diverso de enfermedades con una característica histológica común: la sustitución de hueso normal por tejido compuesto de colágeno y fibroblastos, con cantidades variables de una sustancia mineral que puede ser de hueso, cemento o ambos. Estas lesiones incluyen la displasia fibrosa, la displasia cemento-ósea en sus variantes: periapical, focal o florida, el cementoma gigantiforme familiar y el fibroma osificante cemento-osificante. La osteomielitis es un proceso inflamatorio agudo o crónico de los espacios medulares o corticales del hueso, que se extiende más allá del sitio inicial de desenvolvimiento. La osteomielitis esclerosante difusa es más frecuente en adultos, principalmente en la mandíbula. Se presenta radiográficamente como una lesión radiopaca difusa adyacente a los dientes, que puede ser multifocal. El objetivo de este trabajo fue describir un caso inusual de lesión fibro-ósea, cuyo diagnóstico diferencial se hizo también con la osteomielitis de los maxilares. Se concluyó que las lesiones fibro-óseas benignas, presentaron muchas similitudes con respecto a sus aspectos clínicos, radiográficos e histológicos. Por lo tanto, es fundamental el análisis conjunto de estas informaciones para obtener un diagnóstico definitivo.

  2. Estudo retrospectivo-sistemático da matriz extracelular de tumores mamários caninos

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    Ana Maria Cristina Rabello Pinto da Fonseca Martins

    2002-01-01

    Full Text Available A finalidade do presente trabalho foi efetuar um estudo retrospectivo, de 1932 à 1999 , afim de se estabelecer a casuística desses tumores nos arquivos do Departamento de Patologia da Faculdade de Medicina Veterinária - USP , bem como a freqüência de desmoplasia, metaplasia cartilaginosa e óssea em 578 desses tumores. Entre os 537 tumores malignos, 13.05% foram adenocarcinomas tubulares simples, 3.91% foram adenocarcinomas tubulares compostos, 7.26% adenocarcinomas papilíferos simples, 4.28% adenocarcinomas papilíferos compostos, 23.27% cistoadenocarcinomas papilíferos simples, 8.37% cistoadenocarcinomas papilíferos compostos, 16.38% adenocarcinomas sólidos simples, 6.70% adenocarcinomas sólidos compostos, 2.04% carcinomas de células espinhosas simples, 1.11% carcinomas de células espinhosas compostos, 2.79% carcinomas mucinosos ,8.19% carcinomas anaplásicos ,0.93% carcinomas escamosos, 1.30% fibrossarcomas,.0.18% condrossarcoma, 0.18% osteossarcoma e entre os 41 tumores benignos ,51.21% foram adenomas, 12.19% cistadenomas pailíferos,7.31% papilomas, 4.87% fibroadenomas e 24.39% foram fibroadenomas. Tanto a desmoplasia como a metaplasia foi um achado freqüente nas neoplasias benignas e malignas, mas foram mais freqüentes entre os adenocarcinomas tubulares compostos: 38% apresentaram desmoplasia, 57% metaplasia cartilaginosa e 28% metaplasia óssea. Entre as neoplasias benignas, adenoma apresentou a maior frequência: 14 % com desmoplasia, 29% com metaplasia cartilaginosa e 24% com metaplasia óssea. Os resultados deste estudo enfatizam a complexidade da inter-relação entre as macromoléculas da matriz extracelular e as células tumorais.

  3. Aplicações da técnica de difusão por RM em cabeça e pescoço: um olhar além da anatomia

    Directory of Open Access Journals (Sweden)

    Fabrício Guimarães Gonçalves

    2011-10-01

    Full Text Available DWI é uma técnica totalmente não invasiva que tem sido utilizada com sucesso por muitos anos em imagens do cérebro e recentemente incluída como parte da avaliação de outros sistemas, por exemplo, no abdome e pelve e na cabeça e pescoço. Apesar de a DWI e a medida dos valores de ADC serem capazes de fornecer informações de tipos histológicos específicos de tumores, a maioria dos centros de imagem ainda não os adotaram como parte da rotina na avaliação da cabeça e pescoço. A medida de ADC demonstrou ser útil para discriminar tipos específicos de tumores histológicos, especialmente para diferenciar lesões benignas sólidas de massas malignas, importante na avaliação de linfonodos cervicais, principalmente para diferenciar processos nodais benignos de malignos, para diferenciar as alterações pós-radioterapia de tumor residual e ter uso potencial para predizer sucesso terapêutico. Além disso, DWI/ADC parece ser um método mais seguro e mais acessível, considerando a ausência de radiação ionizante e ao maior custo do FDG-PET na localização de tumores e diferenciar massas benignas de malignas. Com todas essas vantagens e potencialidades, DWI/ADC certamente fará parte da rotina na avaliação por imagem da cabeça e pescoço.

  4. Psychological disorders in adults with inherited cardiomyopathies and Takotsubo syndrome

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    Mariana Suárez Bagnasco

    2016-06-01

    Full Text Available Realizamos una revisión narrativa sobre trastornos psicológicos en adultos con diagnóstico de síndrome de Takotsubo y miocardiopatías hereditarias. Utilizando las bases de datos PubMed y PsycINFO buscamos los trabajos relevantes publicados entre 2000 y 2015. Encontramos doce estudios que exploran alteraciones psicológicas en síndrome de Takotsubo y ocho estudios sobre miocardiopatías hereditarias: cinco enrolaron pacientes con miocardiopatía hipertrófica, dos miocardiopatía dilatada, uno miocardiopatía arritmogénica del ventrículo derecho. Todas las publicaciones reportaron la presencia de trastornos psicológicos. En el síndrome de Takotsubo, la depresión oscila entre el 20,5 y el 48% y la ansiedad estuvo presente entre el 26 y el 56%. Un estudio reporta que la ansiedad aumenta la probabilidad de desarrollar el síndrome de Takotsubo. En la miocardiopatía dilatada, la ansiedad estuvo presente en el 50% de los pacientes y la depresión en el 22%. En la miocardiopatía arritmogénica del ventrículo derecho, la edad más joven, peor capacidad funcional y haber experimentado al menos un shock por desfibrilador automático implantable, fueron predictores independientes significativos de ansiedad tanto específica por el dispositivo como generalizada. En la miocardiopatía hipertrófica, la ansiedad y la depresión estaban presentes en 45,2% y 17,9%, respectivamente. Treinta y siete por ciento cumplía con los criterios de diagnóstico para los trastornos de ansiedad y 21% para los trastornos del estado de ánimo. Cerca de la mitad de los pacientes con miocardiopatía hipertrófica informan dolor en el pecho, disnea y mareos desencadenados por estrés emocional. Debido al reducido número de estudios publicados, las conclusiones son limitadas. No obstante, presentamos algunos de los resultados.

  5. LOS GENES BRCA1 y BRCA2. ESTUDIO MOLECULAR

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    N. Alonso

    2006-11-01

    Full Text Available RESUMENEn los últimos años, se realizaron numerosos estudios para establecer la predisposición hereditaria al cáncer y las alteraciones mutacionales a nivel de genes susceptibles de originar cáncer de mama y ovario. En 1994 se identificaron los genes BRCA1 (Breast Cancer Gene 1 y BRCA2 (Breast Cancer Gene 2 como susceptibles de cáncer de mama y ovario. En la actualidad se sabe que las mutaciones en BRCA1 y BRCA2 están lejos de explicar la totalidad de los casos de cáncer de mama y/o ovario, y a pesar de que se postulan alteraciones mutacionales en otros genes como CHEK2, TP53 y PTEN, el BRCA1 y BRCA2, siguen teniendo su importancia y utilidad en la valoración del riesgo de predisposición hereditaria. Aunque las cifras son variables según los distintos estudios y autores, se trata en cualquier caso de porcentajes importantes. Entre el 15 y el 85% de las mujeres portadoras de mutación BRCA 1 o BRCA 2 tienen riesgo de desarrollar un cáncer de mama y entre un 10 y 60% de desarrollar un cáncer de ovario. ABSTRACT:In the last years, numerous studies were made to establish the hereditary predisposition to the cancer and the mutationals alterations at level of genes susceptible to originate breast and ovarian cancers. In 1994 genes BRCA1 (Breast Cancer Gene 1 and BRCA2 were identified (Breast Cancer Gene 2 as susceptible of both of breast and ovarian cancers. At the present time, it is knows that the mutations in BRCA 1 and BRCA 2 are far from explaining the totality of the cases of breast cancer and/or ovary, and although mutationals alterations in other genes like CHEK2, TP53 and PTEN, the BRCA1 and BRCA2 are postulated, they continue having his importance and utility in the valuation of the risk of hereditary predisposition. Correlations between both BRCA1 and BRCA2 levels with tumour grade metastasis and prognostic accuracy. Between 15 and 85% of the carrying women of mutation BRCA 1 or BRCA 2 have risk of developing a cancer of breast

  6. Distrofia corneal de Schnyder

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    Michel Guerra Almaguer

    Full Text Available La principal entidad hereditaria con depósitos de lípidos en el estroma corneal es la distrofia cristalina central, conocida como distrofia de Schnyder, quien la describió en Suiza en 1927. Se caracteriza por depósitos blanco-amarillentos en el estroma corneal central y superficial. Se presenta un paciente de 28 años, del sexo masculino y piel negra, con antecedente de salud anterior. Acudió a consulta y refirió una disminución de la visión y cambio de coloración progresiva de ambos ojos, de años de evolución. En la exploración oftalmológica de ambos ojos se apreciaron lesiones blanquecinas anulares a nivel del estroma corneal, con ligera turbidez corneal central. Los estudios refractivos realizados constataron un astigmatismo hipermetrópico simple. El resto del examen oftalmológico fue negativo. Para el diagnóstico de certeza se empleó el microscopio confocal. Se concluye que el caso presenta una distrofia corneal estromal de tipo cristalina, de Schnyder.

  7. The dystrophinopathies in Costa Rica

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    Jorge Azofeifa

    2004-09-01

    Full Text Available A five-years long study aiming to describe the basic genetic epidemiology of the dystrophinopathies in Costa Rica recruited 31 patients with clinical symptoms of DMD/BMD at the National Children’s Hospital (HNN. This center is the obligate reference hospital of the national health system for genetic diseases, however, the geographic origin of the patients, a low percentage of deletions and a high proportion of de novo mutations found among them indicate that a significant ascertainment bias impedes a substantial scientific approach to confront and alleviate the problems posed by these severe diseases in Costa Rica. Rev. Biol. Trop. 52(3: 485- 490. Epub 2004 Dic 15.Un estudio de cinco años tendiente a describir la epidemiología genética básica de las distrofinopatías en Costa Rica detectó 31 pacientes con sintomatología de DMD o de BMD en el Hospital Nacional de Niños (HNN, el centro de referencia del sistema nacional de salud para enefrmedades hereditarias, sin embargo, la distribución geográfica de los pacientes, un bajo porcentaje de deleciones y una muy elevada proporción de mutaciones de novo indican que un significante sesgo de averiguación impide el estudio científico de riguroso tendiente a disminuir el impacto de estas enfermedades en Costa Rica.

  8. Deficiencia congénita de proteína C en un recién nacido con trombosis y necrosis de tejidos extensa

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    Bárbara Acosta Batista

    Full Text Available Uno de los trastornos hematológicos más graves del período neonatal es la deficiencia congénita de proteína C, de presentación muy rara, y causa de enfermedad tromboembólica severa y púrpura fulminante en recién nacidos. Se puede sintetizar como una entidad clínico-patológica, de aparición aguda, con trombosis de la vasculatura de la dermis, lo cual conduce a necrosis hemorrágica y progresiva de la piel, asociada a coagulación intravascular diseminada y hemorragia perivascular, que ocurre en el período neonatal. El paciente presentado exhibe los elementos clínico-patológicos que caracterizan la púrpura fulminante, cuyo origen se debe a una deficiencia hereditaria de proteína C, lo cual condujo a la aparición de complicaciones trombóticas severas.

  9. ENPP1 Mutation Causes Recessive Cole Disease by Altering Melanogenesis.

    Science.gov (United States)

    Chourabi, Marwa; Liew, Mei Shan; Lim, Shawn; H'mida-Ben Brahim, Dorra; Boussofara, Lobna; Dai, Liang; Wong, Pui Mun; Foo, Jia Nee; Sriha, Badreddine; Robinson, Kim Samirah; Denil, Simon; Common, John Ea; Mamaï, Ons; Ben Khalifa, Youcef; Bollen, Mathieu; Liu, Jianjun; Denguezli, Mohamed; Bonnard, Carine; Saad, Ali; Reversade, Bruno

    2018-02-01

    Cole disease is a genodermatosis of pigmentation following a strict dominant mode of inheritance. In this study, we investigated eight patients affected with an overlapping genodermatosis after recessive inheritance. The patients presented with hypo- and hyperpigmented macules over the body, resembling dyschromatosis universalis hereditaria in addition to punctuate palmoplantar keratosis. By homozygosity mapping and whole-exome sequencing, a biallelic p.Cys120Arg mutation in ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) was identified in all patients. We found that this mutation, like those causing dominant Cole disease, impairs homodimerization of the ENPP1 enzyme that is mediated by its two somatomedin-B-like domains. Histological analysis revealed structural and molecular changes in affected skin that were likely to originate from defective melanocytes because keratinocytes do not express ENPP1. Consistently, RNA-sequencing analysis of patient-derived primary melanocytes revealed alterations in melanocyte development and in pigmentation signaling pathways. We therefore conclude that germline ENPP1 cysteine-specific mutations, primarily affecting the melanocyte lineage, cause a clinical spectrum of dyschromatosis, in which the p.Cys120Arg allele represents a recessive and more severe form of Cole disease. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Enfermedad poliquística autosómica recesiva Recessive autosomal polycystic disease

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    Sandalio Durán Álvarez

    2007-06-01

    Full Text Available Como enfermedades renales poliquísticas hereditarias se describen clásicamente la autosómica recesiva y la autosómica dominante, mal llamadas enfermedad poliquística de tipo infantily de;tipo adulto, respectivamente, pues ambas pueden verse tanto en una como en otra edad. Los conceptos cambiantes en cuanto a la enfermedad autosómica recesiva, dados por los progresos en el tratamiento de los recién nacidos con la enfermedad, y la localización del gen, que por su mutación la produce, nos motivan hacer esta breve revisión con la finalidad de contribuir a la comprensión de la enfermedad por los estudiantes de medicina y el médico general básico.Recessive autosomal and dominant autosomal polycystic kidney diseases are classically described as hereditary illnesses; they are also called polycystic disease of child type” and of adult typerespectively since both may be seen in any of these two life stages. The changing concepts of recessive autosomal disease, given the advances made in the treatment of newborns with this disease, and the location of the gen, the mutation of which causes it, encouraged us to make a brief literature review to help medical students and general practitioners to understand this disease.

  11. FIBROSIS QUÍSTICA EN EL ADULTO

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    Joel Melo T., DR.

    2015-05-01

    Full Text Available La Fibrosis Quística (FQ es una enfermedad hereditaria autosómica recesiva. La detección precoz sumado a medidas de intervención temprana han modificado el curso de esta enfermedad con mejorías en su sobrevida, lo que ha llevado a una población creciente de pacientes de 18 años. La mutación genética determina una alteración en una Proteína Reguladora de Conductancia Transmembrana (CFTR que afecta a numerosos órganos y sistemas, pero el compromiso pulmonar es el que causa mayor morbimortalidad. El germen más frecuente que infecta a adultos es Pseudomonas aeruginosa y si bien hay una serie de medidas para el manejo de la infección crónica por Pseudomonas las terapia dirigida a la restauración de la función de la proteína CFTRhatomadorelevancia. Cuando la falla respiratoria progresa, la única alternativa disponible es el trasplante pulmonar que mejora la sobrevida y la calidad de vida en estos pacientes.

  12. Consideraciones cardiovasculares del síndrome de Marfán en edades pediátricas

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    Giselle Serrano Ricardo

    2012-06-01

    Full Text Available El síndrome de Marfán es una enfermedad hereditaria del tejido conectivo, que se describe en niños y en adultos, causada por una mutación en el gen que codifica la glicoproteína fibrilina tipo 1. Afecta múltiples órganos y sistemas, fundamentalmente cardiovascular, esquelético, oftalmológico, piel y tegumentos. Se presenta una revisión de los aspectos más actuales del diagnóstico, y la atención multidisciplinaria para lograr una reducción de la morbilidad y mortalidad en los pacientes pediátricos. Se concluye que el uso precoz de betabloqueadores e inhibidores del receptor AT-1 de la angiotensina II (losartán, constituyen actualmente los pilares fundamentales de la terapéutica farmacológica, pues disminuyen la frecuencia de complicaciones cardiovasculares, las cuales determinan el pronóstico de la enfermedad. La cirugía programada de la raíz aórtica, especialmente con preservación valvular, permite mejorar la expectativa de vida al evitar la alta mortalidad de los eventos agudos. Alternativas prometedoras son los procederes híbridos y el intervencionismo endovascular.

  13. Congenital contractural arachnodactyly Síndrome de la arcnodactilia contractural: estudio de un caso esporádico y revisión de la literatura

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    Betty Nishikuni

    1991-02-01

    Full Text Available

    The Congenital Contractural Arachnodactyly Syndrome is a heredltary disorder of connective tissue characterized by multiple congenital contractures, arachnodactyly, dolichostenomella, kyphoscollosis, abnormalities of the external ears and autosomal dominant inheritance. Nearly 50 cases have previously been reported. A new sporadic case is presented. Some clinical and genetic aspects, differential diagnosis and therapeutic approach of this syndrome are discussed.

    El síndrome de la aracnodactilia contractural es una alteración hereditaria del tejido conectivo, caracterizada por múltiples contracturas congénitas, aracnodactilia, dolicostenomelia, cifoescoliosis, dismorfia de los pabellones auriculares y un patrón de herencia autonómico dominante. Se han Informado aproximadamente 50 casos, a los cuales se adiciona uno nuevo, esporádico. Se discuten algunos aspectos clínicos y genéticos, el diagnóstico diferencial y el manejo de estos pacientes.

  14. Descubriendo el pseudoxantoma elástico Discovering the elasticum pseudoxanthoma

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    E Ocampo

    2006-03-01

    Full Text Available Enfermedad hereditaria rara, el pseudoxantoma elástico es un trastorno genético del tejido conectivo, que se caracteriza por fragmentación de las fibras elásticas y posterior calcificación de éstas afectando dermis, vasos sanguíneos y la membrana de Bruch de retina. El patrón de herencia es muy variable, lo que hace posible que esta enfermedad pueda estar subdiagnosticada. La escasa incidencia de esta patología justifica la presentación de dos casos que tuvieron solamente manifestaciones cutáneas.Hereditary disease does not frequent pseudoxanthoma elastic; is a genetic upheaval of the conective weave, that characterizes by fragmentation of elastic fibers and later calcification of these, affecting dermis, blood vessels and membrane of Bruch of retina. The inheritance pattern is very variable which causes that disease; can be subdiagnosed. The litlle incidence of this pathology, causes that in our professional experience we have been able to diagnose two cases in which the manifestations were cutaneous.

  15. Falla cardíaca de alto débito por fístulas arteriovenosas sistémicas en paciente con síndrome de Osler-Weber-Rendu

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    Juan M Senior

    2013-09-01

    Full Text Available Paciente de 65 años, con historia de epistaxis a repetición, sin otros antecedentes patológicos de importancia, quien presentó síntomas de un año de evolución consistentes en disnea de esfuerzo progresiva hasta el reposo, acompañado de ortopnea y edemas que iniciaron en miembros inferiores y progresaron hasta la anasarca. Al examen clínico llamó la atención ingurgitación yugular, hepatomegalia, ascitis y edemas periféricos. La piel presentó telangiectasias en extremidades y mucosas. Se realizaron estudios que reportaron falla cardiaca con severa dilatación de las cavidades derechas, con función sistólica del ventrículo izquierdo conservada. Se demostraron fístulas arteriovenosas en hígado y pulmón. Se estableció el diagnóstico de síndrome de Osler-Weber-Rendu o telangiectasia hemorrágica hereditaria (THH. Se propuso cierre de fístulas por vía percutánea y se planteó posible trasplante hepático como tratamiento; sin embargo, el paciente tuvo una evolución tórpida, presentó fibrilación auricular y embolismo al sistema nervioso central y falleció por enfermedad cerebrovascular.

  16. Applications of the Preclinical Molecular Imaging in Biomedicine: Gene Therapy; Aplicaciones de la Imagen Molecular Preclínica en Biomedicina: Terapia Génica

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    Collantes, M.; Peñuelas, I.

    2014-07-01

    Gene therapy constitutes a promising option for efficient and targeted treatment of several inherited disorders. Imaging techniques using ionizing radiation as PET or SPECT are used for non-invasive monitoring of the distribution and kinetics of vector-mediated gene expression. In this review the main reporter gene/reporter probe strategies are summarized, as well as the contribution of preclinical models to the development of this new imaging modality previously to its application in clinical arena. [Spanish] La terapia génica constituye una nueva y prometedora opción para un tratamiento eficiente y dirigido de numerosas enfermedades hereditarias. Las técnicas de imagen que utilizan radiaciones ionizantes como PET o SPECT son utilizadas para la monitorización no invasiva de la distribución y la cinética de la expresión génica mediada por distintos vectores. En este resumen se explican brevemente los principales sistemas gen reportero/sonda reportera que permiten la visualización in vivo de la expresión génica, así como la aportación de los modelos preclínicos al desarrollo de esta nueva estrategia de imagen previamente a su aplicación en el ámbito clínico.

  17. La conducta de larvas de Drosophila (Diptera; Drosophilidae: su etología, desarrollo, genética y evolución The behavior of Drosophila larvae: their ethology, development, genetics and evolution

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    RAÚL GODOY-HERRERA

    2001-03-01

    Full Text Available Este trabajo, en honor al Profesor Doctor Danko Brncic Juricic (Q.E.P.D., es una revisión de nuestras contribuciones sobre la etología, desarrollo, genética y evolución de patrones de conducta de larvas de Drosophila. Se discute el desarrollo de conductas larvales de forrajeo y sus bases hereditarias. También se discuten estrategias de investigación dirigidas a entender las relaciones entre genotipo y conducta durante el desarrollo de los organismos. Se relacionan patrones de desarrollo de conductas larvales con la filogenia de las especies del grupo mesophragmatica de Drosophila. Finalmente, se distingue entre evolución de elementos de conducta simple y evolución de conductas complejasThis is a review about our contributions in ethology, development, genetics, and evolution of larval behavioral patterns of Drosophila in honor of the late Professor Doctor Danko Brncic Juricic. The developmental behavioral genetics of larval foraging and pupation of Drosophila are discussed. It is also emphasized the importance of research strategies lead to understand properly the relationships between genotype and behavior during development of the organisms. Finally, a comparison between phylogenetic relationships of six Drosophila species of the mesophragmatica group and their developmental patterns of larval behaviors is provided

  18. Urgencia hipertensiva secundaria a enfermedad poliquística renal autosómica recesiva en lactante. Reporte de caso

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    Roxana Quisbert-Cruz

    2017-06-01

    Full Text Available La enfermedad poliquística renal asociada a la fibrosis hepática congénita es una enfermedad hereditaria; se encuentra dentro del espectro de las enfermedades fibroquísticas hepatorrenales. Su frecuencia estimada es de 1 en 20.000 nacidos vivos para la variedad de enfermedad poliquística renal autosómica recesiva y más rara para la variedad autosómica dominante. Se presenta un reporte de caso de un paciente cuyo padecimiento se inició con crisis hipertensiva de difícil control, debido a enfermedad poliquística renal y fibrosis hepática congénita, presentación clínica poco frecuente; cabe mencionar sobre la importancia del control de la tensión arterial para prevenir complicaciones causadas por la hipertensión arterial: hipertrofia cardiaca, falla cardiaca y retinopatía crónica.

  19. DIAGNÓSTICO GENÉTICO PARA ENFERMEDADES NEURODEGENERATIVAS. UN IMPORTANTE DESAFÍO PARA CHILE

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    Dr. Marcelo Miranda C.

    2016-05-01

    Full Text Available En esta revisión se analizan las características hereditarias de las principales condiciones neurodegenerativas (demencias tipo Alzheimer y frontotemporal, enfermedad de Parkinson y otros cuadros como la enfermedad de Huntington. Se hace énfasis en la necesidad de contar con exámenes genéticos de confirmación diagnóstica en estos cuadros, lo que constituye una falencia en nuestro medio. Disponer de estos recursos diagnósticos permite una mejor aproximación al paciente, estableciendo un diagnóstico más certero, un pronóstico con más base y una asesoría genética adecuada. La implementación de una terapia efectiva para cada cuadro, estará basada en un futuro próximo en un diagnóstico más preciso de la condición del paciente y para esto los estudios genéticos son una herramienta muy importante de la que dispone el clínico, además de estudios de imágenes y de laboratorio con otros marcadores humorales.

  20. Discusión: Explicaciones genéticas y psicológicas de la esquizofrenia.Genética de la esperanza

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    Silvio Bolaños-Salvatierra

    2003-01-01

    Full Text Available En este documento se rebaten críticas hechas por Raventós y Jensen al artículo “Genética y comportamiento”. Cuatro temas fueron seleccionados: 1 se determina que los antipsicóticos aparecieron veinte años después de la concepción hereditaria de la esquizofrenia; 2 se considera que la discusión es altamente pertinente, para nada bizantina o irrelevante, debido que persisten prácticas epistémicas riesgosas en los investigadores genético-conductuales; 3 aunque ninguna conducta humana está exenta de influencia constitucional, el enfoque biologicista se ha propasado al pretender explicar genéticamente casi todo, desconfirmando solapadamente la importancia de la historia personal; y, 4 se plantea que la investigación biológica sobrevalora el peso de las anomalías genéticas frente a la historia social, por lo que solo aparenta cautela. Se propone investigar genéticamente la esperanza con el objetivo de saturar a la humanidad con ese tipo de explicaciones, para alcanzar más rápido una convivencia basada en la tolerancia y el respeto.

  1. Placa fibrosa de la frente o del cuero cabelludo: Un marcador cutáneo temprano del complejo de la esclerosis tuberosa Forehead or scalp fibrous plaque: An earley cutaneous marker in tuberous sclerosis complex

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    A. E Saponaro

    2010-09-01

    Full Text Available El complejo de la Esclerosis tuberosa es una afección hereditaria, que se transmite en forma autosómica dominante. Se caracteriza por convulsiones, retraso mental y manifestaciones en diversos órganos. Los signos cutáneos suelen ser determinantes para el diagnóstico de la enfermedad. Entre éstos se destaca la placa fibrosa, la que se localiza más frecuentemente en la frente, pero puede observarse en cualquier área del cuero cabelludo. Cuando está presente, suele ser el signo cutáneo inicial de la enfermedad, como ocurrió en nuestro paciente, subdiagnosticado. Su importancia radica entonces en reconocerlo como un marcador precoz y patognomónico de la enfermedad.The complex of tuberous sclerosis is an hereditary disease that passes in the autosomal dominant way. It is characterized by convulsions, mental retardation and manifestations in different organs. The cutaneous signs are used to be determinant for the diagnosis of the illness. Among these, it is important the fibrous plaque, which is usually localized in the forehead, but it can also be observed in any area of the scalp.When it is presented, it is used to be the first cutaneous sign of the illness, and like it happened in our patient, underdiagnosed. So, the importance of the fibrous plaque lies in recognizing it as an early cutaneous marker and pathognomonic of the disease.

  2. Evaluación Médica Previa a La Práctica Deportiva Para Deportistas Aficionados y de Nivel Competitivo

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    Dr. D. Fernando yáñez

    2012-05-01

    Full Text Available La actividad física y el deporte reducen la mortalidad general y cardiovascular, pero durante la práctica de ejercicio aumenta el riesgo de muerte súbita que puede ser la primera manifestación de una enfermedad cardiovascular no diagnosticada en deportistas previamente asintomáticos. Las causas de muerte súbita difieren según la edad, en los menores de 35 años se debe a patologías congénitas o hereditarias y en los mayores de esta edad a enfermedad coronaria. En el presente artículo se analizan las causas más frecuentes de muerte súbita, así como los protocolos de evaluación médica previa a la práctica de actividad física o deporte propuestos en la literatura para su prevención en deportistas de diferentes edades y nivel de actividad, desde el competitivo de alto rendimiento hasta el recreativo por salud, y utilización del tiempo libre.

  3. The property of Ramon Urquiola, since its establishment until the division in the province of Buenos Aires, between the XIX and XX centuries La propiedad de Ramon Urquiola, desde su constitución hasta el fraccionamiento en la provincia de Buenos Aires, entre los siglos XIX y XX

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    Gloria Cucullu

    2009-01-01

    Full Text Available This research is focused on the following topics: the process of acquiring a large tract of land in Lobos, Buenos Aires, in the early nineteenth century, the social and economic integration of the acquirer and the social and political life of their sons: the changing cultural form and land use through two generations, the social and cultural change as represented by owners who continue to occur due to fractionation hereditary succession, the sales process that leads to total alienation of land in little more than a century, the discussion of the factors leading to this outcome.Este trabajo de investigación está centrado en los siguientes temas: el proceso de adquisición de una gran extensión de tierra en Lobos, provincia de Buenos Aires, a comienzos del siglo XIX; la inserción social y económica del adquirente y la inserción social y política de sus hijos; el cambio de modalidad cultural y de explotación de la tierra a través de dos generaciones; el cambio social y cultural representado por quienes continúan como propietarios al producirse el fraccionamiento debido a las sucesiones hereditarias; el proceso de ventas que lleva a la total enajenación de la tierra en poco más de un siglo; la discusión sobre los factores que llevan a este desenlace.

  4. Nuevas intervenciones en hipertensión arterial pulmonar

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    Juan Esteban Gómez Mesa

    2017-09-01

    Full Text Available El manejo farmacológico de la hipertensión arterial pulmonar se basa en agentes que actúan en tres vías principales: endotelina 1, prostaglandina I2 y óxido nítrico. La mayoría de estudios clínicos para aprobación de medicamentos desarrollados para tratar esta condición, han sido cortos y enfocados en el cambio en la caminata de 6 minutos. Al tener en cuenta que las diferentes formas de hipertensión arterial pulmonar tienen como denominador común para las alteraciones moleculares y celulares el entrecruzamiento celular con la pared vascular asociado a procesos inflamatorios e inmunes inapropiados, disbalance entre la síntesis y degradación de matriz extracelular, alteraciones genéticas (gen BMPR2 en hipertensión arterial pulmonar hereditaria y epigenéticas, se requiere un mejor entendimiento de la fisiopatología de la enfermedad, lo cual permitirá desarrollar nuevos tratamientos o intervenciones en estos pacientes en cada uno de estos niveles.

  5. The spectrum of myopathies in the city of São Paulo

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    José A. Levy

    1976-12-01

    Full Text Available A review of all myopathic patients treated at the Neurologic Clinic of the Medical School of the University of São Paulo during the past 15 years is reported. A total of 466 cases were examined and distributed as follows: 56% of progressive muscular dystrophy; 31% of myasthenia gravis; 6% of polymyositis; 4% of myotonic dystrophy; and the remainder of several different diseases (central core disease, Kearns-syndrome, myotonia congenita, adynamia episodica hereditaria, diabetic myopathy and Eaton-Lambert syndrome. Enzymatic dosages, electromyography, muscle biopsy, electrocardiography and genetic counselling are also reported.Os autores fazem uma revisão de todos os casos de miopatias tratados na Clínica Neurológica da F.M.U.S.P. durante os últimos 15 anos. Foram examinados 466 casos, assim distribuídos: 56% de distrofia muscular progressiva; 31% de miastenia grave; 6% de polimiosite; 4% de distrofia miotônica e, o restante, de várias outras moléstias (Central core disease, síndrome de Kearns, miotonia congênita, adinamia episódica hereditária, miopatia diabética e síndrome de Eaton-Lambert. São relatadas também as dosagens enzimáticas, eletromiografia, biópsia muscular, eletrocardiografia e aconselhamento genético.

  6. [Not Available].

    Science.gov (United States)

    San Mauro Martin, Ismael; Mendive Dubourdieu, Paula; Paredes Barato, Víctor; Garicano Vilar, Elena

    2016-07-19

    Introducción: la tradición de la comida picante desempeña un papel muy importante en el gusto por este tipo de comida y su tolerancia. Las preferencias alimentarias muestran influencia genética y ambiental.Objetivos: estudiar la tolerancia y el gusto por el picante de tres poblaciones, y la influencia hereditaria y del ambiente.Métodos:se realizó una encuesta a 522 sujetos, de tres continentes (Asia, Europa y Latinoamérica) en tres idiomas (español, inglés y chino) a través de Internet. Se realizaron preguntas acerca de la tolerancia al picante, el gusto por los alimentos picantes, su uso, la edad de comienzo de consumo, el gusto del padre y de la madre y si ella lo consumía durante el embarazo y/o lactancia.Resultados: existe diferencia entre el gusto por el picante del hijo y el sexo (p embarazo (p < 0,001) y la lactancia (p = 0,005) y el gusto del padre por el picante (p = 0,003). Existe correlación entre el continente de residencia (p = 0,007) y de nacimiento (p = 0,012) y la tolerancia a los alimentos picantes.Conclusión: la influencia de los progenitores, el género y la composición corporal se relacionaron con gustos y tolerancias diferentes.

  7. Detección de una mutación puntual en el gen receptor Ryanodina (Ryr 1 en cerdos criollos colombianos

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    Muñoz Flórez Jaime Eduardo

    2008-12-01

    Full Text Available El síndrome de estrés porcino (PSS es una enfermedad hereditaria monogénica recesiva relacionada con el gen receptor ryanodina (Ryr1. Utilizando PCR-SSCP y PCR-RFLP se tipificaron genéticamente 14 individuos de cerdos comerciales con el rasgo sindactilia (Casco de Mula-CM, 21 San Pedreños -SP y 100 Zungos- ZN. Las razas CM y SP tuvieron las mismas frecuencias alélicas (F(H = 0.79 y F(h = 0.21, mientras que en los cerdos ZN no se encontró el alelo recesivo (h. La heterocigosidad (He fue de 0.28% para los cerdos CM y 0.23% para los SP. La He para la muestra poblacional fue de 0.066.

  8. Síndrome de McCune Albright

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    Milvia Castillo Guerrero

    2014-08-01

    Full Text Available El síndrome de McCune-Albright es una enfermedad esporádica de causa genética, no hereditaria, clínicamente caracterizada por displasia fibrosa poliostótica, manchas de color café con leche y desórdenes endocrinos, tales como hipertiroidismo y pubertad precoz. Se reporta el caso de un paciente masculino de 10 años, que presentó múltiples fracturas óseas desde los seis meses de edad, hipertiroidismo y desnutrición severa, que causaron retardo en su crecimiento y desarrollo. El proceso de diagnóstico fue demorado por su inusual forma de presentación, pero su evolución después de iniciar el tratamiento fue favorable. Se presenta el caso por la baja frecuencia de este trastorno, asociado a complicaciones endocrino-metabólicas graves que causan la muerte, si no se diagnostica y se trata precozmente

  9. Manifestaciones cardiovasculares de anemia de células falciformes

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    Fernando Manzur

    2015-07-01

    Full Text Available La anemia de células falciformes es una hemoglobinopatía hereditaria producida por la presencia de hemoglobina S, que disminuye la solubilidad y a través del proceso de polimerización da lugar a hematíes en forma de hoz que obstruyen la red microvascular. Se caracteriza por episodios de daño por isquemia-reperfusión que contribuyen a la disfunción de órganos vitales. El advenimiento de la terapia inductora de hemoglobina fetal, asociada a la profilaxis antibiótica, ha permitido prolongar la supervivencia. Sin embargo, al incrementar la longevidad, las complicaciones cardiovasculares se hacen evidentes con el desarrollo de vasculopatía sistémica, infarto agudo de miocardio, hipertensión arterial pulmonar y disfunción ventricular. El objetivo de este artículo es revisar la fisiopatología y el tratamiento de las principales manifestaciones cardiovasculares en pacientes con anemia de células falciformes.

  10. El “cuplón”; unidad funcional del acoplamiento contráctil.

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    Eduardo Rios

    2014-07-01

    Full Text Available Este artículo examina la evolución del concepto de cuplón, unidad funcional del acoplamiento contráctil, originado hace más de quince años con los colegas Gonzalo Pizarro y Michael Stern. Este examen nos permitirá poner al día avances en el estudio del acoplamiento entre la excitación de origen nervioso y la contracción muscular. Como se verá, la investigación en el tema ha tenido recientemente un claro viraje hacia la búsqueda de formas de aplicación de los conceptos básicos en la prevención y el tratamiento de varias enfermedades. A su vez, el estudio de mutaciones hereditarias en las proteínas del cuplón permitió nuevos avances en la comprensión de las interrogantes más básicas (cuáles son sus funciones y sus interacciones supramoleculares en una feliz y bastante inesperada potenciación mutua entre enfoques muy diferentes de la realidad. Este artículo sigue un desarrollo iterativo, describiendo primero los aspectos básicos del tema, pasando luego a los estudios aplicados, y a través de ellos volviendo a cuestiones fundamentales, ahora en pleno proceso de esclarecimiento.

  11. Carcinoma espinocelular infiltrante de base de cráneo en paciente de 16 años con albinismo óculo-cutáneo

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    J.M. Lasso-Vázquez

    2013-12-01

    Full Text Available Presentamos el caso de una adolescente africana de 16 años de edad afectada por albinismo óculo-cutáneo, que desarrolló un carcinoma epidermoide en pabellón auricular derecho que requirió escisión radical y reconstrucción con colgajo TRAM libre. El albinismo es un trastorno metabólico genético que consiste en la incapacidad hereditaria para sintetizar melanina. Tiene dos variantes clínicas: el albinismo ocular y el albinismo óculo-cutáneo. En determinados países africanos, los pacientes afectos por esta enfermedad son socialmente rechazados y por ello no se les presta un control sanitario adecuado. Por esta razón el tumor llevaba varios años de evolución y cuando la paciente fue vista en nuestro centro, existía una infiltración profunda con afectación severa de la base del cráneo. La compleja anatomía de las estructuras vitales en esta región hace que la resección quirúrgica de los tumores sea complicada. Comentamos las peculiaridades en la reconstrucción de casos complejos en la base lateral del cráneo con proyección a la zona temporal.

  12. La historia de la ciencia en la enseñanza de la célula

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    Laura Carrillo

    2012-04-01

    Full Text Available A través de este artículo se propone aportar ideas para sustentar la incorporación de la historia de la ciencia en la enseñanza de la biología. Para ello, se realiza una breve reconstrucción histórica y posteriormente, un análisis exploratorio sobre cuáles son los conceptos acerca de la célula que se incorporan en los libros de texto y sí éstos, tienen relación con cómo se construyó la teoría celular. Con esta propuesta se deja en evidencia que los libros de texto, sólo enseñan conceptos sobre la estructura y función de la célula, relacionados principalmente con aportes del Siglo XIX y que poco se promueven conceptos para la comprensión de la célula como unidad hereditaria de origen, estructuras y funciones de los organelos celulares, cuyas propuestas se consolidaron durante el S.XX.

  13. Neurofibromatosis tipo 2: La historia de Lidia Neurofibromatosis type 2: Life story of Lidia

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    Ares Solanes

    2012-06-01

    Full Text Available La Neurofibromatosis tipo 2 (NF2 es una enfermedad minoritaria hereditaria caracterizada por la presentación progresiva de múltiples tumores, especialmente Schwanomas Vestibulares Bilaterales, a partir de la segunda década de vida. Su tratamiento con cirugía o radioterapia no evita la pérdida de audición. El pronóstico es complicado y los pacientes deben enfrentarse al progresivo deterioro de su calidad de vida. Un estudio cualitativo a través de la historia de vida de nuestra informante clave nos permite explorar y comprender su vivencia, afecta de Neurofibromatosis tipo II (NF2, así como conocer sus necesidades y aprender de sus recursos adaptativos.Neurofibromatosis type 2 (NF2 is a minority hereditary disease characterized by the development of multiple tumours, especially bilateral vestibular schwannomas, in young adults. Treatments with surgery or radiotherapy are performed to delay hearing loss. The prognosis is complicated and patients face the deterioration of their quality of life. A qualitative study through our key subject's life allows us to explore and understand her experience, as a NF2 sufferer, to identify her needs and to learn about her adaptive measures.

  14. ¿CÓMO ORGANIZAR Y ESTRUCTURAR UN PROGRAMA DE SÍNDROMES HEREDITARIOS QUE PREDISPONEN AL DESARROLLO DEL CÁNCER?

    Directory of Open Access Journals (Sweden)

    Dr. Francisco López

    2017-07-01

    Full Text Available Los avances de la medicina nos enfrentan a nuevos desafíos como es el caso de los síndromes hereditarios que predisponen al desarrollo del cáncer. El modelo clásico del médico especialista que trata un tumor específico de su paciente, debería ser cambiado por el del “equipo de salud que asesora a una familia”. El diagnóstico de una enfermedad hereditaria tiene un fuerte impacto sicológico y emocional en cada uno de los miembros de la familia ya que implica adaptarse a cambios en el estilo de vida, adherirse a pautas de vigilancia activa mediante imágenes, exámenes de sangre y controles médicos periódicos e incluso en ciertos casos deberán someterse a cirugías de carácter profiláctico. En vista a este nuevo desafío, las instituciones están viendo en la necesidad de desarrollar e implementar Programas de Riesgo Alto Oncológico conformado por un equipo interdisciplinario, que permita acoger y apoyar a estas familias. En este artículo se describen las características de un programa de alto riesgo oncológico y la experiencia de un centro que ha implementado este programa.

  15. Ventana a la Farmacología

    Directory of Open Access Journals (Sweden)

    Oscar F. Ramos M.

    1995-07-01

    Full Text Available Usos y contraindicaciones del ketoroiaco: El ketorolaco administrado por vía oral, intramuscular o endovenosa por periodos breves, se recomienda para el tratamiento del dolor postoperatorio agudo, moderado o grave. / El tamoxifeno y el riesgo de cancer uterino: El tamoxifeno es una droga antiestrógena que se utiliza en el tratamiento del cáncer mamario. / Usos de Ia DNAs a para el tratamiento de la fibrosis quística: La FDA de Estados Unidos ha aprobado el uso de la DNAsa (domasa alfa, Pulmozyme para el tratamiento de la fibrosis quística, una enfermedad hereditaria caracterizada por la presencia de secreciones mucosas espesas en los pulmones. / Importancia de la acetilcolina neocortical en la memoria espacial: Varios estudios han demostrado la importancia de la acetilcolina en la memoria y el aprendizaje. Lesiones de los núcleos colinérgicos, manipulaciones farmacológicas del sistema colinérgico, transplantes intracerebrales de tejido fetal, y cambios anatómicos de las vías colinérgicas durante el envejecimiento se han correlacionado con alteraciones cognitivas.

  16. Caso atípico de osteoporosis idiopática juvenil

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    Iván Hernández García

    Full Text Available La osteoporosis idiopática juvenil es una enfermedad que aparece en niños y adolescentes, autolimitada, caracterizada por osteoporosis axial y de extremidades, en ocasiones asociada a colapso vertebral, lo que resulta finalmente en cifosis torácica. No se tiene conocimiento, hasta la fecha, de su asociación a alteraciones de la dentición. Se presenta el caso de un adolescente masculino, con historia de retraso en el cambio a la dentición permanente y osteopenia, valorado por varias especialidades médicas como: Medicina Interna, Estomatología, Ortopedia, Endocrinología y Nefrología. Se plantea el diagnóstico de osteoporosis idiopática juvenil, y se descartan, a partir del cuadro sintomatológico y los numerosos complementarios realizados, varias enfermedades hereditarias y adquiridas, entre ellas, la osteogénesis imperfecta tardía y el hiperparatiroidismo. Se destacan en este caso la presencia de alteraciones en la dentición y la poca afectación vertebral.

  17. La nefropatía IgA, la glomerulopatía más frecuente en el mundo

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    Sandalio Durán Álvarez

    Full Text Available La nefropatía inmunoglobulina A es una glomerulonefritis mediada por inmunocomplejos caracterizada por el depósito de inmunoglobulina A1 en el mesangio glomerular. Es la forma más frecuente de glomerulonefritis primaria en el mundo. La probabilidad de deterioro de la función renal a largo plazo, está aumentada por los hallazgos siguientes: hipertensión arterial, hematuria microscópica persistente, proteinuria mayor de 0,5 g/día, descenso de la función renal al comenzar las manifestaciones o hallazgos en la biopsia renal de esclerosis glomerular, esclerosis vascular, fibrosis intersticial, atrofia tubular, formación de crecientes o distribución de IgA en la pared de los capilares glomerulares en la inmunofluorescencia. Son manifestaciones clínicas en la nefropatía inmunoglobulina A la hematuria macroscópica en aproximadamente la mitad de los pacientes al primero o segundo día del inicio de síntomas de infección respiratoria, y está asociada con dolor en el flanco en pacientes menores de 40 años. En los más viejos, la hematuria microscópica es generalmente asintomática, y en ocasiones, detectada en análisis de orina de pesquisa. Entre 10 y 20 % de los pacientes, por lo general aquellos que tienen hematuria y proteinuria ligera, pueden lograr remisión espontánea; pero, entre 25 y 30 % pueden mostrar progresión hacia la enfermedad renal crónica terminal, y la progresión por lo general es lenta (5-20 años. La biopsia renal es la única prueba específica para confirmar el diagnóstico. Los pacientes con hematuria y proteinuria menor de 0,3 g/día que están normotensos, no requieren tratamiento específico con medicamentos, pero necesitan ser controlados periódicamente con análisis de orina, creatinina sérica y medida de la tensión arterial. Los pacientes con proteinuria o hipertensión deben ser tratados enérgicamente con inhibidores de la enzima convertidora. La hipertensión, la proteinuria significativa (> 0,5 g

  18. The effect of ultrasound-guided compression immediately after transrectal ultrasound-guided prostate biopsy on postbiopsy bleeding: a randomized controlled pilot study.

    Science.gov (United States)

    Park, Bong Hee; Kim, Jung Im; Bae, Sang Rak; Lee, Yong Seok; Kang, Sung Hak; Han, Chang Hee

    2017-08-01

    To evaluate whether ultrasound-guided compression performed immediately after transrectal ultrasound (TRUS)-guided prostate biopsy decreases bleeding complications. We prospectively evaluated a total of 148 consecutive patients who underwent TRUS-guided prostate biopsy between March 2015 and July 2016. Systematic 12-core prostate biopsy was performed in all patients. Of these, 100 patients were randomly assigned to one of two groups: the compression group (n = 50) underwent TRUS-guided compression on bleeding biopsy tracts immediately after prostate biopsy, while the non-compression group (n = 50) underwent TRUS-guided prostate biopsy alone. The incidence rate and duration of hematuria, hematospermia, and rectal bleeding were compared between the two groups. The incidence rates of hematuria and hematospermia were not significantly different between the two groups (60 vs. 64%, p = 0.68; 22 vs. 30%, p = 0.362, respectively, for compression vs. non-compression group). The rectal bleeding incidence was significantly lower in the compression group as compared to the non-compression group (20 vs. 44%, p = 0.01). However, there were no significant differences in the median duration of hematuria, hematospermia, or rectal bleeding between the two groups (2, 8, and 2 days vs. 2, 10, and 1 days, p > 0.05, respectively, for compression vs. non-compression group). TRUS-guided compression [p = 0.004, odds ratio (OR) 0.25] and patient age (p = 0.013, OR 0.93) were significantly protective against the occurrence of rectal bleeding after prostate biopsy in multivariable analysis. Although it has no impact on other complications, ultrasound-guided compression on bleeding biopsy tracts performed immediately after TRUS-guided prostate biopsy is an effective and practical method to treat or decrease rectal bleeding.

  19. Spectrum of Glomerulonephritis in Egypt

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    Barsoum Rashad

    2000-01-01

    Full Text Available Identification of the profile of glomerular disease in a particular geographical region is of fundamental academic, clinical and epidemiological importance. It helps in the recognition of specific risk factors and subsequent planning for adequate prevention. In the present study, 1234 consecutive renal biopsies referred to the nephropathology team of Cairo University over two years were retrospectively analyzed. The main indications for biopsy included nephrotic syndrome, persistent sub-nephrotic proteinuria, recurrent hematuria, suspected secondary hypertension, lupus nephritis and acute and chronic renal failure of undetermined etiology. Proliferative forms of glomerulonephritis [GN] (32.1% and focal and segmental glomerulosclerosis [FSGS] were the most prevalent lesions among patients with the nephrotic syndrome (22.6%. In subjects with sub-nephrotic proteinuria, FSGS was the principal lesion followed by proliferative lesions. Although all forms of GN were encountered in those presenting with recurrent hematuria, mesangioproliferative GN and FSGS were significantly more frequent. IgA glomerular deposits were detected in 9.8% of all GNs and 15% of those presenting with hematuria. One half of the biopsies obtained for the assessment of suspected secondary hypertension showed only changes compatible with the effect of hypertension per se, i.e. nephroangiosclerosis. On the other hand, a parenchymal renal lesion was found in 52.9% of biopsies. The common glomerular pathologies in patients with lupus nephritis were Classes III and IV. Among patients with chronic renal failure, the predominant lesion was chronic interstitial nephritis (32.6%. An acute interstitial inflammatory element was also detected in 8.4% of cases. About one third of the biopsies obtained for acute renal failure showed acute tubular (11% or cortical (13.2% necrosis. Another third showed vasculitis (17.6% or acute interstitial nephritis (14.3%, and the remaining showed chronic

  20. The effect of rectal Foley catheterization on rectal bleeding rates after transrectal ultrasound-guided prostate biopsy.

    Science.gov (United States)

    Kilciler, Mete; Erdemir, Fikret; Demir, Erkan; Güven, Oğuz; Avci, Ali

    2008-09-01

    To assess whether Foley catheterization of the rectum after transrectal ultrasound (TRUS)-guided prostate biopsy decreases complication rates. Between June 2000 and September 2006, 275 consecutive patients were evaluated after undergoing TRUS-guided prostate biopsy. All procedures were performed on an outpatient basis. Patients were divided into two groups. In the first group (n = 134), a Foley catheter was inserted into the rectum and inflated to 50 cm(3) after TRUS-guided biopsy. In the second group (n = 141), catheterization was performed without balloon placement. Rectal bleeding, hematuria, hematospermia, infection, and acute urinary retention rates were compared between groups. The mean ages of the patients were 63.3 years +/- 5.6 and 62.1 years +/- 7.2 years in the Foley catheter group and control group, respectively (P = .112). Hematuria, hematospermia, infection, and rectal bleeding occurred in 31 (23.1%), 30 (22.4), nine (6.7%), and two patients (1.5%), respectively, in the Foley catheter group; and in 36 (25.5%), 36 (25.5%), 11 (7.8%), and 25 patients (17.7%), respectively, in the control group. The incidences of infection, hematuria, and hematospermia were not significantly different between groups (P > .05). In contrast, the rectal bleeding rate was significantly lower in the Foley catheter group (1.5%) than in the control group (17.7%; P = .001). Although it has no effect on other complications, TRUS-guided prostate biopsy with rectal Foley catheterization is a useful, practical method to decrease or prevent rectal bleeding.

  1. Visually guided male urinary catheterization: a feasibility study.

    Science.gov (United States)

    Willette, Paul A; Banks, Kevin; Shaffer, Lynn

    2013-01-01

    Ten percent to 15% of urinary catheterizations involve complications. New techniques to reduce risks and pain are indicated. This study examines the feasibility and safety of male urinary catheterization by nursing personnel using a visually guided device in a clinical setting. The device, a 0.6-mm fiber-optic bundle inside a 14F triple-lumen flexible urinary catheter with a lubricious coating, irrigation port, and angled tip, connects to a camera, allowing real-time viewing of progress on a color monitor. Two emergency nurses were trained to use the device. Male patients 18 years or older presenting to the emergency department with an indication for urinary catheterization using a standard Foley or Coudé catheter were eligible to participate in the study. Exclusion criteria were a current suprapubic tube or gross hematuria prior to the procedure. Twenty-five patients were enrolled. Data collected included success of placement, total procedure time, pre-procedure pain and maximum pain during the procedure, gross hematuria, abnormalities or injuries identified if catheterization failed, occurrence of and reason for equipment failures, and number of passes required for placement. All catheters were successfully placed. The median number of passes required was 1. For all but one patient, procedure time was ≤ 17 minutes. A median increase in pain scores of 1 point from baseline to the maximum was reported. Gross hematuria was observed in 2 patients. The success rate for placement of a Foley catheter with the visually guided device was 100%, indicating its safety, accuracy, and feasibility in a clinical setting. Minimal pain was associated with the procedure. Copyright © 2013 Emergency Nurses Association. Published by Mosby, Inc. All rights reserved.

  2. Safety of ultrasound-guided transrectal extended prostate biopsy in patients receiving low-dose aspirin

    Directory of Open Access Journals (Sweden)

    Ioannis Kariotis

    2010-06-01

    Full Text Available PURPOSE: To determine whether the peri-procedural administration of low-dose aspirin increases the risk of bleeding complications for patients undergoing extended prostate biopsies. MATERIALS AND METHODS: From February 2007 to September 2008, 530 men undergoing extended needle biopsies were divided in two groups; those receiving aspirin and those not receiving aspirin. The morbidity of the procedure, with emphasis on hemorrhagic complications, was assessed prospectively using two standardized questionnaires. RESULTS: There were no significant differences between the two groups regarding the mean number of biopsy cores (12.9 ± 1.6 vs. 13.1 ± 1.2 cores, p = 0.09. No major biopsy-related complications were noted. Statistical analysis did not demonstrate significant differences in the rate of hematuria (64.5% vs. 60.6%, p = 0.46, rectal bleeding (33.6% vs. 25.9%, p = 0.09 or hemospermia (90.1% vs. 86.9%, p = 0.45. The mean duration of hematuria and rectal bleeding was significantly greater in the aspirin group compared to the control group (4.45 ± 2.7 vs. 2.4 ± 2.6, p = < 0.001 and 3.3 ± 1.3 vs. 1.9 ± 0.7, p < 0.001. Multivariate logistic regression analysis revealed that only younger patients (mean age 60.1 ± 5.8 years with a lower body mass index (< 25 kg/m2 receiving aspirin were at a higher risk (odds ratio = 3.46, p = 0.047 for developing hematuria and rectal bleeding after the procedure. CONCLUSIONS: The continuing use of low-dose aspirin in patients undergoing extended prostatic biopsy is a relatively safe option since it does not increase the morbidity of the procedure.

  3. Degree of Left Renal Vein Compression Predicts Nutcracker Syndrome

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    Patrick T. Hangge

    2018-05-01

    Full Text Available Nutcracker syndrome (NS refers to symptomatic compression of the left renal vein (LRV between the abdominal aorta and superior mesenteric artery with potential symptoms including hematuria, proteinuria, left flank pain, and renal venous hypertension. No consensus diagnostic criteria exist to guide endovascular treatment. We aimed to evaluate the specificity of LRV compression to NS symptoms through a retrospective study including 33 NS and 103 control patients. The size of the patent lumen at point of compression and normal portions of the LRV were measured for all patients. Multiple logistic regression analyses (MLR assessing impact of compression, body mass index (BMI, age, and gender on the likelihood of each symptom with NS were obtained. NS patients presented most commonly with abdominal pain (72.7%, followed by hematuria (57.6%, proteinuria (39.4%, and left flank pain (30.3%. These symptoms were more commonly seen than in the control group at 10.6, 11.7, 6.8, and 1.9%, respectively. The degree of LRV compression for NS was 74.5% and 25.2% for controls (p < 0.0001. Higher compression led to more hematuria (p < 0.0013, abdominal pain (p < 0.006, and more proteinuria (p < 0.002. Furthermore, the average BMI of NS patients was 21.4 and 27.2 for controls (p < 0.001 and a low BMI led to more abdominal pain (p < 0.005. These results demonstrate a strong correlation between the degree of LRV compression on imaging in diagnosing NS.

  4. Prevalence of asymptomatic urinary abnormalities among adolescents

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    Mohamed Fouad

    2016-01-01

    Full Text Available To determine the prevalence of asymptomatic urinary abnormalities in adolescents, first morning clean mid-stream urine specimens were obtained from 2500 individuals and examined by dipstick and light microscopy. Adolescents with abnormal screening results were reexamined after two weeks and those who had abnormal results twice were subjected to systemic clinical examination and further clinical and laboratory investigations. Eight hundred and three (32.1% individuals had urinary abnormalities at the first screening, which significantly decreased to 345 (13.8% at the second screening, (P <0.001. Hematuria was the most common urinary abnormalities detected in 245 (9.8% adolescents who had persistent urine abnormalities; 228 (9.1% individuals had non glomerular hematuria. The hematuria was isolated in 150 (6% individuals, combined with leukocyturia in 83 (3.3% individuals, and combined with proteinuria in 12 (0.5% individuals. Leukocyturia was detected in 150 (6% of all studied adolescents; it was isolated in 39 (1.6% individuals and combined with proteinuria in 28 (1.1% of them. Asymp- tomatic bacteriuria was detected in 23 (0.9% of all studied adolescents; all the cases were females. Proteinuria was detected in 65 (2.6% of all the studied adolescents; 45 (1.8% indivi- duals had <0.5 g/day and twenty (0.8% individuals had 0.5-3 g/day. Asymptomatic urinary abnormalities were more common in males than females and adolescents from rural than urban areas (P <0.01 and (P <0.001, respectively. The present study found a high prevalence of asymptomatic urinary abnormalities among adolescents in our population.

  5. Henoch-Schönlein Purpura Complicated by Hepatocellular Carcinoma.

    Science.gov (United States)

    Akizue, Naoki; Suzuki, Eiichiro; Yokoyama, Masayuki; Inoue, Masanori; Wakamatsu, Toru; Saito, Tomoko; Kusakabe, Yuko; Ogasawara, Sadahisa; Ooka, Yoshihiko; Tawada, Akinobu; Maru, Yugo; Matsue, Hiroyuki; Chiba, Tetsuhiro

    2017-11-15

    Although Henoch-Schönlein purpura (HSP) is known to be accompanied by malignancies, cases with hepatobiliary cancer are extremely rare. A 62-year-old man with palpable purpura rapidly extending to both lower legs was admitted to our hospital. He was undergoing follow-up for cirrhosis caused by chronic hepatitis B virus infection and hepatocellular carcinoma (HCC). He had renal dysfunction with hematuria and proteinuria and abdominal pain. Based on the clinical presentation and skin biopsy findings, he was diagnosed with HSP. The administration of steroids resulted in the rapid improvement of the patient's symptoms and he was discharged 12 days after admission.

  6. Disease: H00582 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00582 Benign familial hematuria; Thin basement membrane nephropathy Benign famili...hildhood. The glomerular basement membrane is uniformly thin, but renal function is normal. Heterozygous mut...ations in COL4A3 or COL4A4 lead to reduced collagen network levels in the basemen...MIM: 141200 PMID:18094725 (gene, description) ... AUTHORS ... Gubler MC ... TITLE ... Inherited diseases of the glomerular basemen...Wang YY ... TITLE ... Thin basement membrane nephropathy. ... JOURNAL ... Kidney Int 64:1169-78 (2003) DOI:10.1046/j.1523-1755.2003.00234.x

  7. Simple ectopic kidney in three dogs.

    Science.gov (United States)

    Choi, Jiyoung; Lee, Heechun; Lee, Youngwon; Choi, Hojung

    2012-10-01

    Simple ectopic kidney was diagnosed in three dogs by means of radiography and ultrasonography. A 2-year-old castrated male Schnauzer, a 13-year-old female Schnauzer and a 9-year-old male Jindo were referred with vomiting, hematuria and ocular discharge, respectively. In all three dogs, oval-shaped masses with soft tissue density were observed in the mid to caudal abdomen bilaterally or unilaterally, and kidney silhouettes were not identified at the proper anatomic places on abdominal radiographs. Ultrasonography confirmed the masses were malpositioned kidney. The ectopic kidneys had relatively small size, irregular shape and short ureter but showed normal function on excretory urography.

  8. NEFROLITÍASE ASSOCIADO À HIDRONEFROSE TRATADO CIRURGICAMENTE. RELATO DE CASO

    Directory of Open Access Journals (Sweden)

    Filippe Melo Diniz

    2016-01-01

    Full Text Available The presence nephroliths in dogs is a finding of only 5% of the reported uroliths in this species. This report describes a dog, the Miniature Schnauzer breed, seven-years-old, weighing 9.0 kg, with a history of hematuria and pollakiuria now for six days and spewing white stones and sharp in the urine. After imaging, was diagnosed bladder urolithiasis and nephrolithiasis, hydronephrosis early. The animal underwent cystotomy and nefrotomia and which were effective for the resolution of the case. The Use of cyanoacrylate showed efficacy how alternative synthesis of the kidney with hydronephrosis.

  9. Surgical management of bladder transitional cell carcinoma in a vesicular diverticulum: case report.

    LENUS (Irish Health Repository)

    Raheem, Omer A

    2011-08-01

    We report a case of primary transitional cell carcinoma (TCC) of a bladder diverticum along with a literature review. A 55-year-old male presented with painless gross hematuria. A histological diagnosis of TCC within a bladder diverticulum was made following cystoscopical examination. Initially transurethral resection of bladder tumour with subsequent intravesical chemotherapy followed. As a result of recurrence and in view of bladder-sparing therapy, a distal partial cystectomy was performed. This report demonstrates that conservative bladder-sparing treatment can be achieved and subsequently followed by vigilant cystoscopy.

  10. Surgical management of bladder transitional cell carcinoma in a vesicular diverticulum: case report.

    LENUS (Irish Health Repository)

    Raheem, Omer A

    2012-02-01

    We report a case of primary transitional cell carcinoma (TCC) of a bladder diverticum along with a literature review. A 55-year-old male presented with painless gross hematuria. A histological diagnosis of TCC within a bladder diverticulum was made following cystoscopical examination. Initially transurethral resection of bladder tumour with subsequent intravesical chemotherapy followed. As a result of recurrence and in view of bladder-sparing therapy, a distal partial cystectomy was performed. This report demonstrates that conservative bladder-sparing treatment can be achieved and subsequently followed by vigilant cystoscopy.

  11. Adenocarcinoma in a Koff Urinary Ileal Diversion

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    Bradley Sherman

    2017-07-01

    Full Text Available The use of an ileal conduit as a means of treatment for bladder cancer or dysfunction is widely used and understood. However, long term surveillance of that conduit has not been strongly established and set forth as a means of screening. We present a 76yo female with a history of neurogenic bladder secondary to paraplegia who underwent the formation of a “Koff” pouch as a conduit. Nineteen years later she presents with hematuria and was found to have adenocarcinoma originating in her conduit.

  12. Coagulopathy induced by saw palmetto: a case report.

    Science.gov (United States)

    Villanueva, Salvador; González, Jenniffer

    2009-01-01

    Saw palmetto is the most popular herbal supplement used to treat symptoms of benign prostatic hyperplasia (BPH). The safety and efficacy of saw palmetto has been established in the literature. While the majority of studies document the efficacy and safety of saw palmetto, some studies document the adverse side effects, including increased risk of bleeding. There are no reports in the literature about increased prothombin time (PT), partial thromboplastin time (PTT) or international normalized ratio (INR) while using saw palmetto. We present a case of hematuria and coagulopathy in a patient who was using saw palmetto.

  13. A Rare Cause of Death in a Woman: Iatrogenic Bladder Rupture in a Patient With an Indwelling Foley Catheter.

    Science.gov (United States)

    Paul, Anthea B Mahesan; Simms, Lary; Paul, Abraham E; Mahesan, Andrew A; Ramzanali, Ammani

    2016-05-01

    The CDC estimates that 12-25% of all hospitalized patients receive a urinary catheter during their hospital stay. Foley catheter failure is uncommon and Foley catheter failure associated with iatrogenic urinary bladder rupture (IUBR) is extremely rare. Symptoms are often nonspecific and thus misdiagnosis and delayed treatment is common. In this case report, we present a case of IUBR in a woman from Foley catheter failure, which ultimately led to her demise. This case adds to the literature the importance of suspicion for IUBR in patients with indwelling Foley catheters presenting with lower abdominal pain, hematuria, and decreased urine output.

  14. Long-term safety of left renal vein division and ligation to expedite complex abdominal aortic surgery.

    Science.gov (United States)

    Samson, Russell H; Lepore, Michael R; Showalter, David P; Nair, Deepak G; Lanoue, Julien B

    2009-09-01

    Left renal vein division and ligation (LRVDAL) is performed to facilitate complex abdominal aortic surgery. Surgeons restore continuity of the vein due to concern that ligation could cause renal compromise or hematuria. However, we report the short and long-term safety of left renal vein division and ligation. Between 1992 and 2007, we divided the left renal vein in 56 patients (40 males, 16 females) ages 57 to 84 (average 74-years-old) who were treated for aortic occlusive disease (9) or abdominal aortic aneurysm (47). Patients requiring concomitant renal artery reconstruction were excluded from this review. Suprarenal cross-clamp was used in 51 patients with temporary vessel-loop control of the renal arteries. Creatinine (Cr) and glomerular filtration rates (eGFR) were measured pre-, post-, and long-term after surgery. Outpatient records of all patients that had survived more than 12 months were also reviewed in order to evaluate the late effects on renal function or symptoms possibly related to LRVDAL. Median procedure duration was 157 (61-375) minutes. Median cross-clamp time was 16 (10-45) minutes. Median intensive care unit (ICU) and hospital length of stays were 2 (1-11) days and 7 (4-58) days, respectively. There were no deaths. There were no complications directly related to renal vein ligation. Hematuria, seen in 2 patients, was a result of traumatic insertion of a Foley catheter. Median pre-op and discharge Cr levels were 1.1 mg/dL (0.7-2.4 mg/dL) and 1.1 mg/dL (0.6-2.1 mg/dL), respectively (P 2.0 mg/dL remained unchanged post-op. Only 2 patients with a Cr of 2.0 mg/dL and both returned to normal by day 3 post-op. Thirty-six patients have been followed for more than a year (median 34.5 months, maximum 144 months) and Cr has remained stable in all but 2 patients. These 2 patients, both with a pre-op Cr of 1.5 mg/dL, subsequently developed Cr levels of 2.1 mg/dL and 2.4 mg/dL but maintained baseline Cr levels for 25 and 34 months, respectively, before

  15. A bulbar artery pseudoaneurysm following traumatic urethral catheterization.

    Science.gov (United States)

    Bettez, Mathieu; Aubé, Melanie; Sherbiny, Mohamed El; Cabrera, Tatiana; Jednak, Roman

    2017-01-01

    Traumatic urethral catheterization may result in a number of serious complications. A rare occurrence is the development of a urethral pseudoaneurysm. We report the case of a 13-year-old male who required placement of a Foley catheter for an orthopedic surgical procedure. The Foley was misplaced in the bulbourethra, resulting in the development of a bulbar artery pseudoaneurysm. Profuse bleeding via the urethra was noted after removal of the catheter, and the patient experienced severe intermittent hematuria during the postoperative period. Cystoscopy revealed a pulsatile mass within the bulbourethra. Angiography confirmed a bulbar artery pseudoaneurysm, which was successfully embolized with resolution of bleeding.

  16. Multiple recurrences of anti-glomerular basement membrane disease with variable antibody detection: can the laboratory be trusted?

    OpenAIRE

    Liu, Patricia; Waheed, Sana; Boujelbane, Lamya; Maursetter, Laura J.

    2016-01-01

    Anti-glomerular basement membrane (GBM) disease is commonly a monophasic illness. We present the case of multiple recurrences of anti-GBM disease with varying serum anti-GBM antibody findings. A 33-year-old female tobacco user presenting with hematuria was diagnosed with anti-GBM disease by renal biopsy. Five years later, she presented with alveolar hemorrhage and positive anti-GBM antibody. She presented a third time with alveolar hemorrhage but undetectable anti-GBM antibody. With each occu...

  17. Intoxicación por Superwarfarinas

    OpenAIRE

    Patricia Crecente Otero; Jorge Luis Torres Triana; Ronald Macías Casanova; Luis Manuel Sánchez Rodríguez

    2012-01-01

    Las denominadas superwarfarinas se desarrollaron a partir de la década de 1970 como solución a las resistencias que habían desarrollado los roedores a los raticidas hasta entonces existentes1. Sus principales ventajas son su mayor potencia (hasta 100 veces más potentes que la warfarina)2 y el disponer de una semivida más larga (hasta 6-8 semanas). Presentamos el caso de un paciente varón que ingresa en nuestro servicio de Medicina Interna por otorragia y hematuria para estudio. Como único ant...

  18. Recurrent nephrogenic adenoma in a 10-year-old boy with prune belly syndrome : a case presentation.

    Science.gov (United States)

    Vemulakonda, Vijaya M; Kopp, Ryan P; Sorensen, Mathew D; Grady, Richard W

    2008-05-01

    Nephrogenic adenoma is a rare benign lesion of the urinary tract that is associated with a history of irritation or injury of the urothelium. Predisposing factors include infection, calculi, surgery, trauma, and renal transplantation. Nephrogenic adenoma commonly presents with lower urinary tract symptoms or hematuria. We present the case of recurrent nephrogenic adenoma in a 10-year-old boy with a history of prune belly syndrome and discuss management of this disease in the pediatric population. To our knowledge this represents the first reported case of recurrent nephrogenic adenoma associated with prune belly syndrome.

  19. Traumatic renal infarction

    International Nuclear Information System (INIS)

    Yashiro, Naobumi; Ohtomo, Kuni; Kokubo, Takashi; Itai, Yuji; Iio, Masahiro

    1986-01-01

    Four cases of traumatic renal artery occlusion were described and illustrated. In two cases, direct blows to the abdomen compressed the renal artery against the vertebral column. Clinically, they were severely injured with macroscopic hematuria. Aortograms showed abrupt truncation of renal arteries. In the other two, rapid deceleration caused sudden displacement of the kidney producing an intimal tear with resultant thrombosis. Although they showed little injury without macrohematuria, aortograms revealed tapered occlusion of renal arteries. One of them developed hypertension. ''Rim sign'' of post-contrast CT and hypertension resulted from traumatic renal artery occlusion were reviewed. (author)

  20. The giant kidney worm (Dioctophyma renale) infection in man in Australia.

    Science.gov (United States)

    Fernando, S S

    1983-04-01

    A 47-year-old, previously healthy farmer from Grafton, N.S.W. in Australia, developed loin pain and hematuria 2 months after minor trauma to his loin. A renal cyst was found by ultrasound and arteriography. At operation, a thick-walled cyst containing 800 ml of clotted blood was excised together with a small wedge of kidney. Ring-like structures measuring 70 X 45 mu were found in the fibrous cyst wall and in the surrounding fat. These birefringent double-walled "rings" with equally spaced radial striations were identified as the eggs of Dioctophyma renale.

  1. DIAGNOSIS AND PATHOLOGICAL IMPORTANCE OF THE DIOCTOPHYMA RENALE

    Directory of Open Access Journals (Sweden)

    Gordana Tasic

    2001-01-01

    Full Text Available The aim of the paper is to present an exceptionally rare man's helminth causedby the Dioctophyma renale (DR. This sort is primarily a dog's parasite while in somespecial cases it can be a parasite in man's organism with the most frequent location in the kidney pelvis. The patient appears to have been eaten insufficiently roasted fish.The disease has manifested itself in various symptoms (high body temperature, painsin the back, hematuria and dysuria. The diagnosis was made by histological andparasilological examination.

  2. A Rare Cause of Testicular Metastasis: Upper Tract Urothelial Carcinoma

    Directory of Open Access Journals (Sweden)

    Alper Nesip Manav

    2014-01-01

    Full Text Available Metastatic testicular cancers are rare. Primary tumor sources are prostate, lung, and gastrointestinal tract for metastatic testicular cancers. Metastasis of urothelial carcinoma (UC to the testis is extremely rare. Two-thirds of upper tract urothelial carcinoma (UTUC is of invasive stage at diagnosis and metastatic sites are the pelvic lymph nodes, liver, lung, and bone. We report a rare case of metastatic UTUC to the testis which has not been reported before, except one case in the literature. Testicular metastasis of UC should be considered in patients with hematuria and testicular swelling.

  3. Diagnóstico y tratamiento de la esquistosomiasis vesical desde la atención primaria penitenciaria: a propósito de un caso Diagnosis and treatment of bladder schistosomiasis from penitentiary primary care: case report

    OpenAIRE

    A. Bedoya del Campillo; P. A. Martínez-Carpio; M. J. Leal; N. Lleopart

    2012-01-01

    Se describe un caso clínico de un paciente procedente de Senegal con síndrome miccional y hematuria microscópica que fue diagnosticado y tratado de esquistosomiasis vesical en los servicios médicos del Centro Penitenciario de Jóvenes de Barcelona. Según nuestra información en la base de datos Medline no existen casos de esquistosomiasis vesical abordados en atención primaria fuera de áreas endémicas. Los pacientes pueden diagnosticarse y tratarse antes de ser derivados a la asistencia especia...

  4. Prevalence and risk factors of CKD in Chinese patients with periodontal disease.

    Directory of Open Access Journals (Sweden)

    Kejin Liu

    Full Text Available BACKGROUND: Periodontal disease is common among adults and is associated with an increasing risk of chronic kidney disease (CKD. We aimed to investigate the prevalence and risk factors of CKD in patients with periodontal disease in China. METHODS: In the current cross-sectional study, patients with periodontal disease were included from Guangdong Provincial Stomatological Hospital between March 2011 and August 2011. CKD was defined as estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m(2, the presence of albuminuria, or hematuria. All patients with periodontal disease underwent a periodontal examination, including periodontal probing pocket depth, gingival recession, and clinical attachment level by Florida Probe. They completed a questionnaire and had blood and urine samples taken. The adjusted prevalence of indicators of kidney damage was calculated and risk factors associated with CKD were analyzed. RESULTS: A total of 1392 patients with periodontal disease were invited to participate this study and 1268 completed the survey and examination. After adjusting for age and sex, the prevalence of reduced eGFR, albuminuria, and hematuria was 2.7% (95% CI 1.7-3.7, 6.7% (95% CI 5.5-8.1 and 10.9% (95% CI 9.2-12.5, respectively. The adjusted prevalence of CKD was 18.2% (95% CI 16.2-20.3. Age, male, diabetes, hypertension, history of CKD, hyperuricemia, and interleukin-6 levels (≥7.54 ng/L were independent risk factors for reduced eGFR. Female, diabetes, hypertension, history of CKD, hyperuricemia, high level of cholesterol, and high sensitivity C-reactive protein (hsCRP (≥ 1.03 mg/L and TNF-α levels (≥ 1.12 ng/L were independently associated with an increased risk of albuminuria. Female, lower education (hematuria. CONCLUSIONS: 18.2% of Chinese patients with periodontal disease have proteinuria, hematuria, or reduced eGFR, indicating the presence of kidney damage

  5. Metanephric Adenofibroma associated with Papillary Renal CeU Carcinoma

    International Nuclear Information System (INIS)

    Roa, Carmen Lucia B; Navarrete, Maria Constanza

    2008-01-01

    Metanephric adenofibroma is an infrequent biphasic epithelial-stromal renal tumor, occasionally associated with papillary renal cell carcinoma. We describe a case of a girl with a four year clinical history of intermittent hematuria; she was diagnosed, using a left-side tru-cut renal biopsy, with a Wilms' tumor with stromal and epithelial component, with no sign of anaplasia. Later, through the product of the left-side nephrectomy that was performed at the National Cancer institute of Colombia, she was diagnosed with metanephric adenofibroma associated with papillary renal cell carcinoma

  6. A rare complication after renal transplantation: Forgotten stent

    Directory of Open Access Journals (Sweden)

    Mustafa Karabıcak

    2015-07-01

    Full Text Available In renal transplantation surgery, double J stents (DJS are often used to reduce complications, protect the anastomosis between ureter and bladder, provide drainage in ureteral obstructions and enhance healing if there is an ureter injury. Urinary tract infections, hematuria and irritative voiding symptoms are the early complications of DJS. Migration, fragmantation, encrustation and rarely sepsis are among the late complications of DJS. In this report we describe a renal transplantation case whose DJS stent was forgotten because the patient did not attend the regular follow-up and noticed 5 years after surgery.

  7. Tubulovillous Adenoma in a Urethral Neobladder Anastomosis

    Directory of Open Access Journals (Sweden)

    Bradley A. Morganstern

    2015-11-01

    Full Text Available We present a case of a tubulovillous adenoma arising in a neobladder that was managed by cystoscopic resection. A 64 year-old male underwent a cystectomy with creation of an ileocolic neobladder urinary diversion for T2 urothelial carcinoma of the bladder. Nine years following his surgery, the patient noted several episodes of gross hematuria. Cystoscopic evaluation revealed the rare occurrence of a 3 cm tubulovillous adenoma with high-grade dysplasia at the neck of the neobladder.

  8. Fluorodeoxyglucose positron emission tomography-computed tomography findings in a case of xanthogranulomatous pyelonephritis

    Science.gov (United States)

    Joshi, Prathamesh; Lele, Vikram; Shah, Hardik

    2013-01-01

    Xanthogranulomatous pyelonephritis (XGNP) is an uncommon condition characterized by chronic suppurative renal inflammation that leads to progressive parenchymal destruction. This condition can clinically present as recurrent urinary tract infections, flank pain, hematuria, and occasionally sepsis, and weight loss. This condition is usually associated with obstructing renal calculus. We present 18-fluorodeoxyglucose positron emission tomography-computed tomography (18-FDG PET/CT) findings in an elderly male suffering from pyrexia and weight loss and suspected urinary tract infection. PET/CT findings in this case lead to diagnosis of XGNP. This diagnosis should be kept in mind while evaluating similar symptoms and PET/CT scan findings. PMID:24019680

  9. Primary Malignant Melanoma of the Genitourinary Tract with Upper and Lower Tracts Involvement

    Directory of Open Access Journals (Sweden)

    Broderick Sutton

    2013-01-01

    Full Text Available A 91-year-old female presented with lower extremity swelling and shortness of breath. Laboratory analysis revealed elevations in blood urea nitrogen and creatinine along with microscopic hematuria on urinalysis. Computed tomography imaging showed moderate right hydronephrosis with dilatation of the proximal ureter with a soft tissue density at a transition point. Endoscopic evaluation revealed multiple raised, fleshy, and hemorrhagic masses throughout the bladder which are present in both ureters. Biopsy of these lesions revealed malignant melanoma invading the lamina propria. No dermatologic lesions were identified suggesting a primary malignant melanoma of the genitourinary system.

  10. Re-recognition of Age-dependent Reference Range for the Serum Creatinine Level in Teenagers - A Case of Slowly Progressive Tubulointerstitial Nephritis which Occurred in an Adolescent.

    Science.gov (United States)

    Ono, Hiroyuki; Nagai, Kojiro; Shibata, Eriko; Matsuura, Motokazu; Kishi, Seiji; Inagaki, Taizo; Minato, Masanori; Yoshimoto, Sakiya; Ueda, Sayo; Obata, Fumiaki; Nishimura, Kenji; Tamaki, Masanori; Kishi, Fumi; Murakami, Taichi; Abe, Hideharu; Kinoshita, Yukiko; Urushihara, Maki; Kagami, Shoji; Doi, Toshio

    2017-08-15

    For the first time, a 15-year-old boy was found to have a slight degree of proteinuria and microscopic hematuria during annual school urinalysis screening. His kidney function had already severely deteriorated. A kidney biopsy revealed tubulointerstitial nephritis (TIN) with diffuse inflammatory cell infiltration. His medical records showed his serum creatinine level to be 0.98 mg/dL two years ago, which was abnormally high considering his age. Although the etiology of slowly progressive TIN was unclear, glucocorticoid and immunosuppressant therapy improved his kidney function. This case report suggests that all doctors should recognize the reference range for the serum creatinine level in teenagers.

  11. Efficacy study of Styplon Vet Bolus as supportive therapy in management of hemorrhagic conditions of ruminants

    Directory of Open Access Journals (Sweden)

    B R Ravikumar

    Full Text Available On-field trial was conducted in dairy animals to evaluate efficacy of Styplon Vet Bolus (M/s Himalaya Drug Company, Banglore, India as supportive therapy in management of hemorrhagic conditions (Hematuria, hemoagalectia, bleeding wounds, uterine bleeding and epistaxis of ruminants. Styplon Vet 1-2 boli twice daily was administered to cows and buffaloes, and ½ bolus twice daily for sheep till they recover clinically. The results indicated that Styplon Vet Bolus is a safe and effective styptic in ruminants. [Vet World 2009; 2(12.000: 470-471

  12. Lower tract neoplasm: Update of imaging evaluation.

    Science.gov (United States)

    Hartman, Robert; Kawashima, Akira

    2017-12-01

    Cancers of the lower urinary tract can arise from the bladder, urachus or urethra. Urothelial carcinoma of the bladder (UCB) is the most common of these. The presentation of bladder, urachal and urethral cancers can differ but many result in hematuria as an initial indication. The diagnosis and staging of these cancers often necessitate radiologic imaging often in the form of cross-section CT urography or MR urography. The following article reviews the specific nature of lower tract cancers and their imaging. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Wilms tumor in a child with trisomy 13.

    Science.gov (United States)

    Sweeney, H; Pelegano, J

    2000-01-01

    A 4-year-old black boy with trisomy 13, a history of frequent urinary tract infections, and a horseshoe kidney with painless gross hematuria was examined. An abdominal mass was detected and surgically resected. Examination of the surgical specimen revealed a Wilms tumor. Given the concurrence of trisomy 13 and Wilms tumor and the presence of another such case in the literature, there may be just cause to suspect a locus on chromosome 13 that affects the probability of developing Wilms tumor. Given the increasingly longer survival of patients with trisomy 13, clinicians may need to be aware of the possibility of renal malignant disease in this population of patients.

  14. Ureteroiliac Artery Fistula in a Young Woman with Short Bowel Syndrome for Radiation Enteritis

    Directory of Open Access Journals (Sweden)

    Lidia Santarpia

    2010-01-01

    Full Text Available Ureteral-iliac artery fistula is a rare and potentially life-threatening complication, typically occurring after radiation therapy in already surgically treated cancer patients. This case report describes the diagnostic challenges and the successful management, with the positioning of an intra-arterial prosthesis, of a fistula between the internal iliac artery and the left ureter presenting as massive hematuria in a young woman with history of total colectomy and pelvic radiotherapy for rectal cancer and subsequent wide ileal resections and bilateral ureteral stent positioning for radiation enteritis. Ureteroiliac artery fistulas require a prompt diagnosis and intervention, to avoid life threatening clinical events.

  15. Síndrome nefrítico

    OpenAIRE

    Zalba, Javier; Rahman, Ramiro; Bibiloni, Norma; Amoreo, Oscar; Ruscasso, Javier; Suárez, Ángela; Cobeñas, Carlos; Spizzirri, Ana

    2006-01-01

    El síndrome nefrítico se caracteriza por la combinación de hematuria y proteinuria como manifestación de injuria glomerular, generalmente asociadas a oliguria, hipertensión arterial y edema. La causa más común de síndrome nefrítico es la glomerulonefritis post estreptocócica, secundaria a cepas nefritogénicas de Estreptococo ß hemolítico del grupo A. Causas menos frecuentes son: otras...

  16. Retrograde transurethral balloon dilation of the prostate

    International Nuclear Information System (INIS)

    Castaneda, F.; Reddy, P.; Wasserman, N.F.; Lund, G.; Hulbert, J.; Hunter, D.; Castaneda-Zuniga, W.R.; Amplatz, K.

    1986-01-01

    A series of patients with documented benign prostatic hypertrophy evaluated by urodynamic studies, voiding cystourethrography, retrograde urethrography, and MR imaging underwent dilation performed using a retrograde transurethral approach with 25-mm balloon dilators inflated at a pressure of 3-4 atm for 10 minutes. Immediately after the procedure, retrograde and voiding cystourethrography as well as MR imaging were performed. A Foley catheter was left in place for 24 hours. Complete relief of symptoms has occurred in all of the patients during the follow-up period. No significant complications other than transient hematuria resulted from the procedure. Results of the comparison studies and of MR imaging are discussed

  17. A Rare Prostatic Diagnosis of an Old Man: A Pure Prostatic Leiomyoma

    Directory of Open Access Journals (Sweden)

    W. M. van Ulden-Bleumink

    2013-01-01

    Full Text Available A pure leiomyoma of the prostate is a rare benign tumor. An 82-year-old man was referred to our urology department with gross hematuria and complete urinary retention. Examination revealed a benign prostatic hyperplasia. Transrectal ultrasound showed a prostate of 125 mL. Serum PSA was 1.9 µg/L. A simple retropubic prostatectomy was performed. Histopathological examination showed a pure leiomyoma of the prostate, without the presence of glandular prostate tissue. The diagnosis, characteristics, and treatment of this tumor are described.

  18. Glomerulonefritis aguda post-infecciosa asociada a neumonía neumocócica Acute post infectious glomerulonephritis associated to pneumococcal pneumonia

    OpenAIRE

    S. Fernández de Miguel; E. de Goicoechea Manzanares; M. Gaboli; J.M. Sánchez Granados; V. Murga Herrera

    2009-01-01

    Presentamos un niño de 6 años con insuficiencia renal aguda secundaria a glomerulonefritis asociada a neumonía neumocócica. El paciente presentó en primer lugar un síndrome nefrítico con hematuria, proteinuria, oliguria, edemas y deterioro de la función renal, siendo diagnosticado a continuación de neumonía con derrame pleural. La función renal se normalizó tras 72 horas, persistiendo una hipertensión arterial que precisó tratamiento en la fase aguda. El cuadro se resolvió sin secue...

  19. Unusual Clinical Presentation of Ethylene Glycol Poisoning: Unilateral Facial Nerve Paralysis

    Directory of Open Access Journals (Sweden)

    Eray Eroglu

    2013-01-01

    Full Text Available Ethylene glycol (EG may be consumed accidentally or intentionally, usually in the form of antifreeze products or as an ethanol substitute. EG is metabolized to toxic metabolites. These metabolites cause metabolic acidosis with increased anion gap, renal failure, oxaluria, damage to the central nervous system and cranial nerves, and cardiovascular instability. Early initiation of treatment can reduce the mortality and morbidity but different clinical presentations can cause delayed diagnosis and poor prognosis. Herein, we report a case with the atypical presentation of facial paralysis, hematuria, and kidney failure due to EG poisoning which progressed to end stage renal failure and permanent right peripheral facial nerve palsy.

  20. Unusual Spread of Renal Cell Carcinoma to the Clivus with Cranial Nerve Deficit

    OpenAIRE

    Okudo, Jerome; Anusim, Nwabundo

    2016-01-01

    Renal cell carcinoma (RCC) has unusual presentation affecting elderly males with a smoking history. The incidence of RCC varies while the incidence of spread of RCC to the clivus is rare. The typicality of RCC presentation includes hematuria, flank pain, and a palpable flank mass; however, RCC can also present with clival metastasis. The unique path of the abducens nerve in the clivus makes it susceptible to damage in metastasis. We report a case of a 54-year-old African American female that ...

  1. Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis

    International Nuclear Information System (INIS)

    Oliai, Caspian; Fisher, Brandon; Jani, Ashish; Wong, Michael; Poli, Jaganmohan; Brady, Luther W.; Komarnicky, Lydia T.

    2012-01-01

    Purpose: To provide a retrospective analysis of the efficacy of hyperbaric oxygen therapy (HBOT) for treating hemorrhagic cystitis (HC) and proctitis secondary to pelvic- and prostate-only radiotherapy. Methods and Materials: Nineteen patients were treated with HBOT for radiation-induced HC and proctitis. The median age at treatment was 66 years (range, 15–84 years). The range of external-beam radiation delivered was 50.0–75.6 Gy. Bleeding must have been refractory to other therapies. Patients received 100% oxygen at 2.0 atmospheres absolute pressure for 90–120 min per treatment in a monoplace chamber. Symptoms were retrospectively scored according to the Late Effects of Normal Tissues—Subjective, Objective, Management, Analytic (LENT-SOMA) scale to evaluate short-term efficacy. Recurrence of hematuria/hematochezia was used to assess long-term efficacy. Results: Four of the 19 patients were lost to follow-up. Fifteen patients were evaluated and received a mean of 29.8 dives: 11 developed HC and 4 proctitis. All patients experienced a reduction in their LENT-SOMA score. After completion of HBOT, the mean LENT-SOMA score was reduced from 0.78 to 0.20 in patients with HC and from 0.66 to 0.26 in patients with proctitis. Median follow-up was 39 months (range, 7–70 months). No cases of hematuria were refractory to HBOT. Complete resolution of hematuria was seen in 81% (n = 9) and partial response in 18% (n = 2). Recurrence of hematuria occurred in 36% (n = 4) after a median of 10 months. Complete resolution of hematochezia was seen in 50% (n = 2), partial response in 25% (n = 1), and refractory bleeding in 25% (n = 1). Conclusions: Hyperbaric oxygen therapy is appropriate for radiation-induced HC once less time-consuming therapies have failed to resolve the bleeding. In these conditions, HBOT is efficacious in the short and long term, with minimal side effects.

  2. Transitional cell carcinoma in dogs: a report of two cases, mother and Daughter

    OpenAIRE

    Martins Leal, Leonardo; Fernandes Machado, Márcia Rita; Bignotto Ferreira, Fernanda; Margarete Didoné, Eliangela; Bruno de Souza, Isabela

    2012-01-01

    El carcinoma de células transicionales que comúnmente se encuentra en la región del trígono de la vejiga se presenta con signos inespecíficos de las vías urinarias inferiores, tales como hematuria, estranguria, poliaquiuria e incontinencia urinaria. Las obstrucciones uretrales y ureterales ocurren en algunos casos. Factores etiológicos, endógenos e iatrogénicos han sido catalogados como la causa de la enfermedad. El presente reporte tiene como objetivo hacer la descripción y tratamiento de do...

  3. Cases of a Borderline Pathology That Can Mimic Bladder Cancer: Primary Amyloidosis of Urinary Bladder

    Directory of Open Access Journals (Sweden)

    Cemal Selçuk İşoğlu

    2015-06-01

    Full Text Available Amyloidosis is a disease characterised by accumulation of a fibrillar protein called amyloid in the extracellular space. The kidneys, ureters and the bladder can be affected in the urinary tract. However, primary amyloidosis of bladder is a rare entity. Macroscopic hematuria could be the first and only symptom of primary amyloidosis of the bladder; therefore, it has similar findings with urinary tract malignancies. Histopathological evaluation is mandatory for the diagnosis. Follow-up should always include cystoscopic evaluation as recurrence is expected in the natural course.

  4. Henoch-Schönlein purpura without systemic involvement beginning with acute scrotum and mimicking torsion of testis

    Directory of Open Access Journals (Sweden)

    Levent Verim

    2013-04-01

    Full Text Available Henoch-Schönlein purpura (HSP is the most common systemic vasculitis in children. Typical presentations of HSP are palpable purpura of the small vessels in the hips and lower limbs, abdominal pain, arthritis, and hematuria. Scrotal involvement manifested by the presence of scrotal pain and swelling during the course of the disease is rarely seen. HSP without systemic involvement with acute scrotum mimicking testicular torsion is even rare in the medical literature. In most cases, patients with this disease achieve complete recovery. Herein, we report an interesting HSP case with skin symptoms but without systemic involvement and then progression to acute scrotum resembling torsion of testis.

  5. Spontaneous rupture of the urinary bladder in a woman with radiation cystitis. A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kurizaki, Yoshiki; Ishizuka, Osamu [Kofu Municipal Hospital, Yamanashi (Japan)

    1997-07-01

    A 79-year-old woman was admitted to our hospital with gross hematuria and abdominal pain. She had had a uterine cancer 11 years previously and received 56 Gy {sup 60}Co external irradiation combined with 129 Gy {sup 137}Cs internal irradiation. She had a sign of pan-peritonitis. An emergency operation revealed an intraperitoneal rupture of the dome of the urinary bladder 8 cm in length. Because a primary suturing of the bladder wall was unsuccessful, bilateral cutaneous ureterostomy was performed. Histologically, the ruptured bladder wall showed a mucosal erosion and fibrosis of the muscle layer. (author)

  6. RABDOMIÓLISIS REITERADA COMO POSIBLE CAUSA DE NEFROPATÍA CRÓNICA

    Directory of Open Access Journals (Sweden)

    Vilas MF

    2013-05-01

    Full Text Available It is widely described in the literature that rhabdomyolysis can potentially cause acute renal failure, and that repeated episodes of hemoglobinuria-hematuria (paroxysmal hemoglobinuria and IgA glomerulopathy can generate progressive renal damage and consequently chronic renal disease. In this report we describe a chronic renal failure that due to its clinical context and way of installation, it strongly suggests the possibilityof the existence of a mechanism of chronic renal damage (causal or concausal secondary to repeated episodes of rhabdomyolysis.

  7. [Collagen nephritis].

    Science.gov (United States)

    Lago, N R; Bulos, M J; Monserrat, A J

    1997-01-01

    Fibrillar collagen in the glomeruli is considered specific of the nail-patella syndrome. A new nephropathy with diffuse intraglomerular deposition of type III collagen without nail and skeletal abnormalities has been described. We report the case of a 26-year-old woman who presented persistent proteinuria, hematuria, deafness without nail and skeletal abnormalities. The renal biopsy showed focal and segmental glomerulosclerosis by light microscopy. The electron microscopy revealed the presence of massive fibrillar collagen within the mesangial matriz and the basement membrane. This is the first patient reported in our country. We emphasize the usefulness of electron microscopy in the study of glomerular diseases.

  8. Epidermoid cyst in the kidney.

    Science.gov (United States)

    Desai, Saral; Thakur, Sudeep; Menon, Santosh; Desai, Sangeeta B

    2011-09-01

    We report an extremely rare case of an epidermoid cyst in the kidney of a 74-year-old man who had presented with painless hematuria. Radiologic examination revealed a cyst in the kidney that was thought to be neoplastic. The patient underwent surgery to remove the cyst, and we received the nephrectomy specimen. A 6-cm cyst with no solid areas was seen. On histologic examination, this was an epidermoid cyst. We reviewed the published data and discuss the possible theories of origin of this rare condition. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. An exceedingly rare cause of secondary hypertension: bilateral renal artery dissection possibly secondary to extracorporeal shock-wave lithotripsy (ESWL).

    Science.gov (United States)

    Orhan, Ozbek; Kultigin, Turkmen; Osman, Koc; Yalcin, Solak; Melih, Anil; Niyazi, Gormus

    2011-01-01

    Extracorporeal shock-wave lithotripsy (ESWL) is an effective and relatively non-invasive treatment modality for ureteral or renal calculi. Although it has been accepted as a safe procedure, minor and major complications have been reported after ESWL. Spontaneous renal artery dissection (SRAD) is a rare and usually misdiagnosed condition because of non-specific presentation of the patients. Depending on the severity of the extent of the dissection non-operative or surgical treatment modalities could be performed. We represent a patient with complaints of bilateral flank pain, hematuria and hypertensive urgency who was diagnosed as having bilateral SRAD possibly secondary to ESWL and chronic hypertension.

  10. Radiation nephritis following total-body irradiation and cyclophosphamide in preparation for bone marrow transplantation

    International Nuclear Information System (INIS)

    Bergstein, J.; Andreoli, S.P.; Provisor, A.J.; Yum, M.

    1986-01-01

    Two children prepared for bone marrow transplantation with total-body irradiation and cyclophosphamide developed hypertension, microscopic hematuria, proteinuria, diminished renal function, and anemia six months after transplantation. Light microscopy of the kidneys revealed mesangial expansion, glomerular capillary wall thickening, and lumenal thrombosis. Electron microscopy demonstrated widening of the subendothelial space due to the deposition of amorphous fluffy material. In one patient, immunofluorescence microscopy revealed glomerular capillary wall deposition of fibrin and immunoglobulins. The clinical and histologic findings support the diagnosis of radiation nephritis. Patients prepared for bone marrow transplantation with total-body irradiation and cyclophosphamide should be followed closely after transplantation for the development of hypertension, proteinuria, and renal insufficiency

  11. A bulbar artery pseudoaneurysm following traumatic urethral catheterization

    Science.gov (United States)

    Bettez, Mathieu; Aubé, Melanie; Sherbiny, Mohamed El; Cabrera, Tatiana; Jednak, Roman

    2017-01-01

    Traumatic urethral catheterization may result in a number of serious complications. A rare occurrence is the development of a urethral pseudoaneurysm. We report the case of a 13-year-old male who required placement of a Foley catheter for an orthopedic surgical procedure. The Foley was misplaced in the bulbourethra, resulting in the development of a bulbar artery pseudoaneurysm. Profuse bleeding via the urethra was noted after removal of the catheter, and the patient experienced severe intermittent hematuria during the postoperative period. Cystoscopy revealed a pulsatile mass within the bulbourethra. Angiography confirmed a bulbar artery pseudoaneurysm, which was successfully embolized with resolution of bleeding. PMID:28163815

  12. Placenta paraaortic with bladder invasion: A plea for multidisciplinary approach

    International Nuclear Information System (INIS)

    Shawish, Fahmy M. I.; Hammad, Fayez T.; Kazim, Essa M.

    2007-01-01

    Placenta previa percreta with the urinary bladder invasion is a rare but potentially lethal condition. It has an increasing clinical significance due to its association with previous cesarean sections and uterine curettage. Herein, we report on a patient with placenta percreta and bladder invasion, who presented with hematuria and in whom delivery was delayed to almost full term highlighting the potential catastrophic results and the need for a multidisciplinary approach with the need to involve surgeons who are familiar with vascular and urologic surgery. We also present an elegant MRI of placenta percreta invading the urinary bladder, which shows that MRI is potentially an excellent diagnostic diagnostic modality in this difficult condition. (author)

  13. [Autosomal dominant polycystic kidney].

    Science.gov (United States)

    Jorge Adad, S; Estevão Barbosa, M; Fácio Luíz, J M; Furlan Rodrigues, M C; Iwamoto, S

    1996-01-01

    A 48-year-old male had autosomic dominant polycystic kidneys with dimensions, to the best of our knowledge, never previously reported; the right kidney weighed 15,100 g and measured 53 x 33 x 9cm and the left one 10.200 g and 46 x 21 x 7cm, with cysts measuring up to 14cm in diameter. Nephrectomy was done to control persistent hematuria and to relief disconfort caused by the large kidneys. The renal function is stable four years after transplantation.

  14. Análise computacional da textura de tumores de mama em imagens por ultrassom de pacientes submetidas a cirurgia conservadora Computer-assisted analysis of breast tumors texture on sonographic images of patients submitted to breast-conserving surgery

    Directory of Open Access Journals (Sweden)

    Carolina Maria de Azevedo

    2009-12-01

    Full Text Available OBJETIVO: Avaliar as características de textura de lesões de mama em imagens por ultrassom de pacientes submetidas a cirurgia conservadora que apresentaram, ou não, recidiva. MATERIAIS E MÉTODOS: As imagens de ultrassom de 36 pacientes submetidas a cirurgia conservadora, com 12 tendo apresentado recidiva local e 24 que não apresentaram recidiva no local da cirurgia, foram divididas em: 3 malignas na mama oposta, 7 nódulos benignos, 5 hiperplasias atípicas e 9 alterações fibrocísticas. A textura das lesões foi quantificada utilizando-se dez parâmetros calculados da matriz de coocorrência e da curva de complexidade. Análise discriminante linear foi aplicada aos parâmetros para discriminação de lesões de mama em pacientes submetidas a cirurgia conservadora que apresentaram, ou não, recidiva. RESULTADOS: Avaliando-se a capacidade dos parâmetros em distinguir as recidivas do grupo composto por lesões não recidivas benignas e hiperplasias atípicas, obteve-se especificidade de 100%, com valores de acurácia e sensibilidade superiores a 91%. Num segundo teste, foi possível distinguir as cinco hiperplasias, das lesões não recidivas benignas. CONCLUSÃO: Apesar do número reduzido de casos, os resultados obtidos são encorajadores, sugerindo que o uso da quantificação da textura pode auxiliar na diferenciação entre lesões benignas, hiperplasias atípicas e lesões malignas de origem recidiva.OBJECTIVE: The purpose of this study was to assess the features of breast lesion texture on sonographic images of patients submitted to breast-conserving surgery, with or without tumor recurrence. MATERIALS AND METHODS: Sonographic images of 36 patients submitted to conservative surgery for breast cancer, 12 of them with, and 24 without local recurrence, included 3 contralateral malignant lesions, 7 benign lumps (3 cysts and 4 fibroadenomas, 5 atypical hyperplasias and 9 fibrocystic changes. The quantification of features of breast

  15. Injeção de corticosteróide em patologias vocais inflamatórias crônicas, revisão da literatura Steroid injection in chronic inflammatory vocal fold disorders, literature review

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    Andrea Maria Campagnolo

    2008-12-01

    Full Text Available Os corticosteróides são potentes inibidores da inflamação e da cicatrização. Administração local de esteróides diretamente na laringe tem sido relatada em diversas patologias laríngeas. OBJETIVO: O objetivo desse estudo é realizar uma revisão da literatura sobre o uso de infiltração de corticosteróide em pregas vocais, em pacientes com patologias vocais benignas, inflamatórias e crônicas de laringe. METODOLOGIA: Realizou-se uma busca eletrônica na base de dados Medline, selecionando-se estudos clínicos que utilizavam corticosteróides em patologias benignas da laringe. RESULTADOS: Os corticosteróides são indicados nas seguintes situações: 1 doenças inflamatórias agudas, principalmente naquelas relacionadas a edema que comprometa a via aérea; 2 doenças auto-imunes com alterações laríngeas; 3 estenose laríngea; 4 em lesões benignas inflamatórias das pregas vocais, como nódulos, pólipos e edema de Reinke, para diminuir o processo inflamatório pré-cirúrgico ou na tentativa de se evitar uma intervenção cirúrgica; 5 em fonocirurgia, com o objetivo de reduzir a formação de cicatriz. Seu uso pode ser profilático, visando à prevenção da formação de cicatriz ou terapêutico em uma cicatriz já formada. CONCLUSÃO: Os corticosteróides podem ser considerados uma opção terapêutica importante no manejo de várias patologias, principalmente aquelas de origem inflamatória que causam alterações vocais.Steroids are potent inhibitors of inflammation and wound repair. Local administration of steroids directly into the larynx has been reported in many laryngeal diseases. AIM: The purpose of this study is to review related literature about the use of steroid injection in patients with benign, inflammatory and chronic vocal disease. METHODOLOGY: We performed an electronic survey in Medline database and selected clinical trials regarding steroid use in benign laryngeal diseases. RESULTS: Steroids are indicated in

  16. Ressecção Histeroscópica do Endométrio: Resultados e Fatores de Risco para insucesso

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    Rodrigues Frederico Faria

    2001-01-01

    Full Text Available Objetivo: estudar o resultado da ablação endometrial histeroscópica, com o uso de ressectoscópio, em pacientes com sangramento uterino anormal de etiologia benigna e refratária ao tratamento clínico, e relatar os fatores associados aos insucessos. Métodos: foram avaliados retrospectivamente informações sobre 64 pacientes com sangramento uterino anormal de causa benigna, submetidas à intervenção entre abril de 1994 e fevereiro de 2000. A média de idade foi de 42,9 anos e a paridade média, de 2,6 partos. Foi realizada histeroscopia diagnóstica com biópsia endometrial pré-operatoriamente. Duas pacientes receberam previamente gestrinona, seis danazol e 44 análogo do GnRH. No ato cirúrgico realizou-se a cauterização elétrica do fundo uterino e das regiões cornuais. Depois, com o ressectoscópio, foi removido o endométrio até 1 cm cranialmente ao orifício interno e na profundidade de 2 a 3 mm na musculatura. A distensão uterina se fazia com glicina a 1,5% até há dois anos, quando se passou a usar o manitol a 3%. O seguimento foi de 11,5 meses em média. Resultados: estabeleceu-se amenorréia em 31,2% das pacientes e hipomenorréia em 45,3%. Houve persistência do sangramento anormal em 23,5%. Houve uma perfuração uterina na cérvico-dilatação (1,5%. Os resultados foram melhores nas pacientes com mais de 40 anos de idade, nas multíparas e nas que usaram análogos do GnRH. Nos casos de falhas houve freqüência estatisticamente significante (p=0,04 de miomas submucosos de 46,6% contra 20,6% no grupo com hipomenorréia e 20% no grupo com amenorréia. O uso de análogo do GnRH fez decrescer de modo significante (p=0,03 os insucessos. No grupo de pacientes nos quais se considerou haver falha da cirurgia, 46% tiveram, ao exame anatomopatológico, endométrio secretor; no grupo com hipomenorréia, 10,3% tiveram este resultado histológico e no grupo com amenorréia, 10%, o que não apresentou significância estatística (p=0

  17. Comparación de los efectos del D-004, imipramina y sertralina en el modelo de nado forzado en ratones Comparative effects of D-004, Imipramine and Sertraline in the forced swimming test in mice

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    Daisy Carbajal Quintana

    2012-09-01

    Full Text Available Introducción: La finasterida, inhibidor de la 5 a-reductasa, se emplea en el tratamiento de la hiperplasia prostática benigna, y ocasiona entre sus efectos adversos un aumento de cuadros de depresión. El D-004 es un extracto lipídico extraído a partir del fruto de la palma real (Roystonea regia, inhibe la 5 a-reductasa y previene la hiperplasia prostática benigna, y muestra un efecto antidepresivo moderado en el ensayo de nado forzado y suspensión por la cola. Objetivo: comparar el efecto del D-004 con la imipramina y la sertralina sobre la duración de las conductas de inmovilidad, nado y escalado en el ensayo de nado forzado. Métodos: se distribuyeron los ratones en ocho grupos: control (vehículo, tres tratados con D-004 (100, 250 y 500 mg/kg, dos con sertralina y dos con imipramina (30 y 50 mg/kg respectivamente. Estos se colocaron en un cilindro de cristal que contenía agua a una altura de 6 cm y se cuantificaron las conductas. Resultados: la administración oral de D-004 (100, 250 y 500 mg/kg durante 14 días redujo significativamente el tiempo de inmovilidad con respecto al grupo control (17, 22 y 25 % y aumentó significativamente la conducta de nado en 1,58, 1,68 y 1,74 veces. Este efecto resulta moderado (25 % comparado con las reducciones alcanzadas por la sertralina y la imipramina (³ 60 %. Las dosis mayores (250 y 500 mg/kg ocasionaron incrementos de la conducta de escalado, 2,79 y 3,55 veces superiores a la del grupo control, lo que mostró semejanza con la imipramina, aunque con una menor eficacia. Conclusiones: el D-004 ejerce un moderado efecto antidepresivo, lo que pudiera contribuir al manejo de los pacientes con hiperplasia prostática benigna en los cuales se informa coincidencia de cuadros depresivos.Introduction: Finasteride is a 5 a-reductase inhibitor to treat benign prostatic hyperplasia (BPH and one of the adverse effects is the increase of depressive symptoms. D-004 is a lipid extract from the real palm

  18. Condutas pós-manobra de Epley em idosos com VPPB de canal posterior Conduct after Epley's maneuver in elderly with posterior canal BPPV in the posterior canal

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    Ana Paula do Rego André

    2010-06-01

    Full Text Available A Vertigem Postural Paroxística Benigna é a mais comum das vestibulopatias periféricas, principalmente em idosos e apresenta como etiologia predominante nessa população à degeneração da mácula utricular. OBJETIVO: Comparar a eficácia das condutas pós-manobra de Epley. Desenho do Estudo: Estudo de coorte contemporâneo longitudinal. MATERIAL E MÉTODO: Participaram do estudo 53 voluntários com Vertigem Postural Paroxística Benigna de canal semicircular posterior, distribuídos em Grupo 1, submetidos à manobra de Epley associada ao uso do colar cervical e orientações pós-manobra; Grupo 2 submetido a manobra de Epley sem uso do colar cervical e/ou restrições pós-manobra, e Grupo 3 submetido à manobra de Epley associada com o uso de um minivibrador, sem uso de colar cervical e/ou restrições pós-manobra. RESULTADOS: Nos três grupos, o número de manobras de Epley variou de uma a três. Aplicou-se o Dizziness Handicap Inventory brasileiro pré e pós-tratamento e observou-se diferença estatisticamente significativa na maioria dos escores pré e pós-tratamento para os grupos avaliados. CONCLUSÃO: Independentemente da conduta pós-manobra de Epley selecionada para o tratamento da Vertigem Postural Paroxística Benigna, essa se mostrou eficaz quando se comparou o Dizziness Handicap Inventory brasileiro pré e pós-tratamento.Benign Paroxysmal Positional Vertigo is the most common peripheral vestibular disorder, especially in the elderly and presents as the predominant etiology in this population of the degeneration of the utricular macula. AIM: To compare the effectiveness of the approaches after Epley maneuver. Study Design: longitudinal cohort. MATERIALS AND METHODS: The study included 53 volunteers with Benign Paroxysmal Positional Vertigo of the posterior semicircular canal, divided into Group 1, who underwent Epley maneuver associated with the use of neck collar and post-maneuver instructions, Group 2 underwent the Epley

  19. Quais as características propostas pelo BIRADS-US que melhor diferenciam nódulos malignos dos benignos? What characteristics proposed by BIRADS ultrasound better distinguish between benign and malignant nodes?

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    Eduardo Carvalho Pessoa

    2007-12-01

    Full Text Available OBJETIVO: analisar qual das características propostas pelo BIRADS-US tem maior impacto na diferenciação das lesões benignas das malignas. MÉTODOS: estudamos as características ultra-sonográficas do BIRADS em 384 nódulos submetidos à biópsia percutânea no período de fevereiro de 2003 a dezembro de 2006. Utilizou-se, para o exame, o aparelho Logic 5, com transdutor linear multifreqüencial de 7,5-12 MHz. A análise ultra-sonográfica do nódulo foi baseada no BIRADS-US levando em conta: forma, orientação, margem, limites da lesão, ecogenicidade, características acústicas posteriores, o tecido circunjacente e a presença de calcificações. Estes dados foram submetidos à análise estatística com modelo de regressão logística. Para o estudo de associação entre estas variáveis utilizamos o teste do c² e também calculamos a sensibilidade e a especificidade das variáveis "tecido ao redor", "calcificações", "efeito posterior", "limite da lesão" e "orientação". RESULTADOS: as lesões benignas representaram 42,4% e as malignas, 57,6%. A análise por regressão logística encontrou odds ratio (OR aumentado para câncer de 7,7 vezes quando o tecido ao redor esteve alterado, de 6,2 vezes quando houve presença das microcalcificações no interior das lesões, de 1,9 quando o efeito acústico foi sombra, de 25,0 vezes quando houve o halo ecogênico e de 7,1 vezes quando a orientação foi não paralela. CONCLUSÕES: dentre as características estudadas, o limite da lesão, representado pela presença ou não do halo ecogênico, é o mais importante diferenciador das massas benignas das malignas.PURPOSE: to analyze which characteristics proposed by the BIRADS lexicon for ultrasound have the greatest impact on distinguishing between benign and malignant lesions. METHODS: ultrasonography features from the third edition of the BIRADS were studied in 384 nodes submitted to percutaneous biopsy from February 2003 to December 2006, at

  20. Adenoma corticosuprarrenal no funcionante Non-functional corticosuprarenal adenoma

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    Evelio Salvador Reyes Balseiro

    2011-12-01

    Full Text Available Alrededor del 50 % de las tumoraciones corticosuprerrenales son benignas y funcionales, muchas son sólidas con signos y síntomas de exceso de glucocorticoides (Cushing o mineralocorticoides (Conn. El otro 50 % de neoplasias sólidas corresponde a carcinomas adrenocorticales primarios, la mitad funcionales. Dentro de las tumoraciones sólidas benignas la más frecuente es el adenoma. Se presenta un paciente de 36 años de edad, de piel blanca, sexo masculino, con buena salud anterior, que ingresó por astenia desde hace 6 meses y dolor abdominal en el flanco derecho, de ligera intensidad, irradiado a la espalda, además de la pérdida de peso. Al examen físico se constata tumoración en flanco derecho. Se diagnostica tumoración suprarrenal voluminosa por ultrasonografía, tomografía axial computarizada y elevación del cortisol en sangre. Se extirpa el tumor por una incisión combinada anterior y lateral en posición semidecúbito, que brindó un buen campo, y se obtuvieron excelentes resultados. El diagnóstico anatomopatológico fue adenoma corticosuprarrenal, que se analizan y comparan con otros reportes.About the 50 % of the cortical-suprarenal tumor are benign and functional, much of them are solid with signs and symptoms of glucocorticoids (Cushing or mineralocorticoid (Conn. The remainder 50 % of solid neoplasm corresponds to primary adrenocortical carcinomas whose half is functional. Within the benign solid tumors the more frequent is the adenoma. This is the case of a white male patient aged 36 with a prior good health admitted due to asthenia from 6 months ago and slightly intensive abdominal pain the right flank irradiating to back as well as weight loss. In physical examination it was verified a right flank tumor. A bulky suprarenal tumor was diagnosed by ultrasonography, computerized axial tomography and a rise of blood cortisol. Tumor is removed b y anterior and lateral combined incision in semi-decubitus position allowed a