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Sample records for hemangiomas orbitarios infantiles

  1. Hemangiomas infantiles

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    Carolina Hernández-Zepeda; María Teresa García- Romero

    2017-01-01

    Las lesiones vasculares en lactantes y niños se clasifican principalmente en dos grupos: tumores y malformaciones vasculares. Los hemangiomas infantiles se encuentran dentro del grupo de tumores benignos junto con otros como el granuloma piógeno, hemangioendotelioma kaposiforme y el hemangioma en penacho. Sin embargo, los hemangiomas infantiles son los tumores vasculares más comunes.

  2. Propranolol (Infantile Hemangioma)

    Science.gov (United States)

    Propranolol oral solution is used to treat proliferating infantile hemangioma (benign [noncancerous] growths or tumors appearing on ... infants 5 weeks to 5 months of age. Propranolol is in a class of medications called beta ...

  3. Hemangioma cavernoso orbitario causante de proptosis del globo ocular izquierdo

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    Yaney González Yglesias

    2012-02-01

    Full Text Available Paciente de 65 años, con antecedentes de hipertensión arterial y cardiopatía isquémica, que asistió a consulta en el departamento de Neurooftalmología, con protrusión del globo ocular izquierdo de aproximadamente 1 año de evolución, no dolorosa, además cierta disminución de la agudeza visual en dicho ojo. El fondo de ojo arrojó una discreta elevación del sector nasal inferior del disco en OI. Se realizó tomografía axial computarizada de órbita y resonancia magnética nuclear de órbitas. En ambas se apreció lesión en porción media superior de órbita izquierda, que comprimía el músculo recto superior. Se realizó cirugía orbitaria para extraer la lesión y se concluyó el diagnóstico histológico como un hemangioma cavernoso orbitario.

  4. Differential diagnosis of infantile hemangiomas.

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    Perman, Marissa J; Castelo-Soccio, Leslie; Jen, Melinda

    2012-08-01

    1.Compare and contrast infantile hemangiomas with other vascular anomalies that may be confused clinically.2.Describe the vascular anomalies classification system according to the International Society for the Study of Vascular Anomalies (ISSVA), highlighting the differences between vascular tumors, such as infantile hemangiomas, and vascular malformations.3.Briefly review associated signs or syndromes found in the context of certain vascular anomalies.Infantile hemangiomas are the most common benign vascular tumor in infancy but may mimic many other types of vascular anomalies. In many cases, the appearance, time of onset, growth pattern, and consistency of infantile hemangiomas make the diagnosis straightforward (see "Pathogenesis of Infantile Hemangiomas" on p. 321). However, many other vascular lesions can appear quite similar to infantile hemangiomas, especially early in life, and at times this makes the correct diagnosis challenging. Copyright 2012, SLACK Incorporated.

  5. Inheritance Patterns of Infantile Hemangioma

    National Research Council Canada - National Science Library

    Eeva Castrén; Päivi Salminen; Miikka Vikkula; Anne Pitkäranta; Tuomas Klockars

    2016-01-01

      BACKGROUND AND OBJECTIVE: Infantile hemangioma (IH) includes, among its other risk factors, familial clustering, but a definitive understanding of IH's inheritance model and genetic basis is lacking...

  6. [Cutaneous infantile hemangiomas].

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    Barreau, M; Dompmartin, A

    2017-06-01

    Superficial vascular anomalies are a heterogeneous group of diseases, developed from various types of vessels and differentiated by their clinical presentation, progression, and prognosis. Their classification was first published by Mulliken and Glowacki in 1982, then endorsed by the International society of the study of vascular anomalies (ISSVA) in 1996 and updated in 2014. It separates vascular anomalies into two categories: vascular tumors characterized by cellular proliferation and vascular anomalies that are structural anomalies of blood vessels. Infantile hemangiomas (IHs) are the most frequent childhood vascular tumor. In most cases, IHs are small, involute progressively with or without a few sequelae, and do not require any treatment. However, in particular localizations or in complicated hemangiomas, treatment is essential to limit tumor growth and accelerate their involution. Propranolol is now the first-line treatment. Its efficacy and safety have been clearly demonstrated. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  7. Infantile periocular hemangioma

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    Mehdi Tavakoli

    2017-01-01

    Full Text Available Infantile periocular hemangiomas (IPH are common benign vascular tumors that present early in childhood. They typically show a rapid nonlinear growth pattern a few weeks after birth during a proliferative phase, then continue with an involution phase and may result in serious ocular or systemic complications. Theses tumors may present in a range of small isolated lesions to multiple, diffuse involvements. Understanding the nature of the disease, the natural course, complications, indications for intervention, and treatment modalities would be helpful for ophthalmologists, who will likely be consulted for periocular cases. In this review, we present recent opinions about the pathogenesis, diagnosis, and treatment options for patients with IPH.

  8. Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma

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    Siu Ying Angel Nip; Kam Lun Hon; Wing Kwan Alex Leung; Leung, Alexander K. C.; Choi, Paul C. L.

    2016-01-01

    Hemangioma is the most common vascular tumor of infancy; presentation is often as cutaneous infantile hemangioma (IH). Cutaneous hemangioma is a clinical diagnosis. Most IHs follow a benign course, with complete involution without treatment in the majority of cases. Visceral hemangioma often involves the liver and manifests as a life-threatening disorder. Hepatic hemangiomas may be associated with high output cardiac failure, coagulopathy, and hepatomegaly which generally develop between 1 an...

  9. Infantile hepatic hemangioma: a diagnostic dilemma

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    Fehmida Najmuddin

    2014-10-01

    Full Text Available Infantile hepatic hemangioma is a tumor arising from the mesenchymal liver tissue. Presentation varies from being asymptomatic to having life threatening complications. They can manifest as solitary or multicentric lesions. We hereby, report a one and half month old child who presented with respiratory distress and was incidentally found to have a liver mass, which eventually was diagnosed as infantile hepatic hemangioma and successfully treated with propranolol.

  10. Infantile hepatic hemangioma: a diagnostic delimma

    OpenAIRE

    Najmuddin, Fehmida; Sharif, Mumtaz; Kotrashetty, Veeranna; Patel, Harsh; Puskur, Dedeepya

    2014-01-01

    Infantile hepatic hemangioma is a tumor arising from the mesenchymal liver tissue. Presentation varies from being asymptomatic to having life threatening complications. They can manifest as solitary or multicentric lesions. We hereby, report a one and half month old child who presented with respiratory distress and was incidentally found to have a liver mass, which eventually was diagnosed as infantile hepatic hemangioma and successfully treated with propranolol.

  11. Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma

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    Siu Ying Angel Nip

    2016-01-01

    Full Text Available Hemangioma is the most common vascular tumor of infancy; presentation is often as cutaneous infantile hemangioma (IH. Cutaneous hemangioma is a clinical diagnosis. Most IHs follow a benign course, with complete involution without treatment in the majority of cases. Visceral hemangioma often involves the liver and manifests as a life-threatening disorder. Hepatic hemangiomas may be associated with high output cardiac failure, coagulopathy, and hepatomegaly which generally develop between 1 and 16 weeks of age. Mortality has been reportedly high without treatment. We report a rare case of a male infant with neonatal hemangiomatosis with diffuse peritoneal involvement, which mimicked a malignant-looking tumor on imaging, and discuss therapeutic options and efficacy. Propranolol is efficacious for IH but generally not useful for other forms of vascular hemangiomas, tumors, and malformations. In our case of neonatal peritoneal hemangiomatosis, propranolol appears to have halted the growth and possibly expedite the involution of the hemangiomatosis without other treatments.

  12. Infantile hemangiomas, complications and follow-up.

    Science.gov (United States)

    Akcay, Arzu; Karakas, Zeynep; Saribeyoglu, Ebru Tugrul; Unuvar, Aysegul; Baykal, Can; Garipardic, Mesut; Anak, Sema; Agaoglu, Leyla; Ozturk, Gulyuz; Devecioglu, Omer

    2012-10-01

    To study the risk factors for hemangioma-related complications, treatment indications and analyze the outcome of patients with infantile hemangioma. Retrospective. University hospital. Fifty-five patients (1-69 months; median: 12 months) with infantile hemangioma with mean follow-up 19 months. The eligibility was based on the criteria of the International Society for the Study of Vascular Anomalies (ISSVA). The surgical treatment included total excision whereas medical treatment was carried out by interferon and /or corticosteroids. Data was collected including sex, age, prematurity, age at onset, number, anatomic location and size of hemangioma, age at treatment, cause of treatment decision, family history, presence of extra malformations, involvement of internal organs, presence of life altering or life threatening complications, response to treatment, dose and duration of medications, complications associated with treatment, follow-up period, and final outcome. Thirty-four (62%) patients were followed-up without treatment, whereas 21 others underwent treatment including steroids, interferon, and surgery. The size of hemangioma was a major factor that predicted hemangioma-related complications (P=0.002). Patients with hemangioma related complications had bigger lesions (size >40 cm² or the longest size on a single plane >5 cm). Nineteen patients (34%) had complications, but only 8 (14.5%) out of them had life or function-threatening complications. Although dosing and treatment protocol is still debatable, steroids and interferon are good options for hemangioma treatment. The management strategy should be individualized for each case.

  13. Propranolol for Treatment of Genital Infantile Hemangioma.

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    Tran, Christine; Tamburro, Joan; Rhee, Audrey; Golden, Alex

    2016-03-01

    Genital infantile hemangiomas are vascular anomalies that often require complex management and interdisciplinary care. Propranolol was first used to treat patients with infantile hemangiomas in 2008 and has since gained acceptance as first-line therapy. We review the presentation, course, management and outcomes of all cases of genital infantile hemangiomas managed by propranolol administration at a single institution from April 2010 to July 2014. During the study period 9 patients with genital infantile hemangiomas were referred to our hemangioma treatment clinic. Propranolol was initially administered under careful outpatient monitoring at a dose of 1 mg/kg daily in 8 patients. One patient, a 700 gm premature infant, was started on therapy in the inpatient setting at 0.5 mg/kg daily, given the history of prematurity. All patients underwent successful increase of dose to at least 2 mg/kg for the observation phase after tolerating the starting doses. One patient discontinued propranolol prematurely per parental request due to concern regarding peripheral vasoconstriction. Otherwise, no patient demonstrated significant hypotension, symptomatic bradycardia, hypoglycemia or other major side effect requiring treatment discontinuation. All patients who continued the treatment protocol had excellent response to therapy. Propranolol therapy for genital infantile hemangiomas was successfully initiated and the dosage increased in 9 young children without significant side effects and with marked improvement in all patients who continued on treatment. Propranolol is the only Food and Drug Administration approved therapy for treatment of patients with this vascular anomaly and should be considered first-line therapy for genital infantile hemangiomas. Copyright © 2016 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  14. Infantile hemangiomas: from pathogenesis to clinical features

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    Rosenblatt A

    2012-06-01

    Full Text Available Adena Rosenblatt,1 Erin F Mathes,2 Kristina W Rosbe31Department of Pediatrics, University of California, San Francisco, 2Division of Pediatric Dermatology, Departments of Dermatology and Pediatrics, University of California, San Francisco, 3Division of Pediatric Otolaryngology, Department of Otolaryngology – Head and Neck Surgery, University of California, San Francisco, CA, USAAbstract: Infantile hemangiomas (IH are benign vascular tumors consisting of a collection of immature cells, including progenitor stem cells and disorganized blood vessels. They are the most common benign tumors in childhood. Recently, there have been significant, exciting advancements in the understanding of the pathogenesis and treatment of infantile hemangiomas, which are discussed in this review. The decision to initiate treatment for IH is based on many factors, including size and location, functional compromise, psychosocial implications, and risks and benefits of the proposed therapy. For most families of children with hemangiomas, education about the natural history of IH and reassurance are often the only "treatment" required. A minority of patients with large, complex lesions or lesions that cause functional compromise require early intervention. These patients and families benefit from a multidisciplinary approach to care in vascular birthmark centers. Ongoing multi-institutional clinical trials will provide further important data on the efficacy and safety of hemangioma treatments.Keywords: progenitor stem cell, glucose transporter 1, PHACES, LUMBAR, infantile hemangioma

  15. [Giant infantile hepatic hemangioma: which therapeutic options?].

    Science.gov (United States)

    Gonçalves, Cristina; Lobo, Luisa; Anjos, Rui; Salgueiro, Carlos; Lopes, Ana Isabel

    2013-01-01

    Infantile hepatic hemangioma is the third most frequent liver tumor in children and the most common below 6 months of age. Therapeutic options depend on clinical manifestations and should be tailored on an individual patient basis. We present the case of a 4 year old boy with neonatal diagnosis of large vascularized liver tumor with imagiological criteria of infantile hepatic hemangioma. We highlight the occurrence of heart failure and Kasabach-Merrit syndrome (thrombocytopenia, anemia) that have spontaneously regressed. During follow up, sequential imaging (ultrasound with Doppler, magnetic resonance imaging, dynamic contrast enhancement computed tomography) confirmed the hypothesis of IHH, allowing vascular mapping of the lesion. From the first year on, we observed a favorable course with progressive tumor regression. In the present case, a conservative approach has been maintained, but the best therapeutic option remains unclear. We highlight the specific features of this case, discussing the most cost-effective approach.

  16. Management of infantile hemangiomas: Current trends

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    Gomathy Sethuraman

    2014-01-01

    Full Text Available Infantile hemangiomas (IH are common vascular tumours. IH have a characteristic natural course. They proliferate rapidly during the early infantile period followed by a period of gradual regression over several years. Most of the uncomplicated IH undergo spontaneous involution, with a small proportion of cases requiring intervention. These are children with IH in life-threatening locations, local complications like haemorrhage, ulceration and necrosis and functional or cosmetic disfigurements. Systemic corticosteroids have been the first line of treatment for many years. Recently, non-selective beta-blockers, such as oral propranalol and topical timolol, have emerged as promising and safer therapies. Other treatment options include interferon α and vincristine which are reserved for life-threatening haemangiomas that are unresponsive to conventional therapy. This review mainly focuses on the current trends and evidence-based approach in the management of IH.

  17. Current perspectives on the optimal management of infantile hemangioma

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    Grzesik P

    2017-12-01

    Full Text Available Peter Grzesik, June K Wu Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA Abstract: Infantile hemangiomas (IHs are the most common benign tumor of infancy. As our understanding of their pathobiology has evolved, treatment has become more focused and tailored to specifically treat IH while minimizing adverse effects. Propranolol has gained FDA approval as the first medical therapy for a traditionally surgical disease. This review provides readers with an overview of IH, treatment modalities, and addresses specific considerations in IH disease management. Keywords: infantile hemangioma, medical treatment indications, propranolol, complications of infantile hemangioma

  18. The changing face of complicated infantile hemangioma treatment.

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    Menapace, Deanna; Mitkov, Mario; Towbin, Richard; Hogeling, Marcia

    2016-10-01

    Infantile hemangiomas are the most common vascular tumors of infancy. A multidisciplinary approach including dermatologists, otolaryngologists, plastic surgeons, hematologists/oncologists and interventional/diagnostic radiologists is crucial for appropriate management of children with complicated infantile hemangiomas. Since its unforeseen discovery in 2008, propranolol has become the first-line treatment for infantile hemangiomas, eclipsing systemic corticosteroids and radiologic intervention. There are still, however, uncommon indications for more aggressive interventional management. We review the 2014-updated International Society for the Study of Vascular Anomalies (ISSVA) classification for vascular anomalies. Additionally, we suggest management algorithms for complicated lesions, including recommendations for radiologic and surgical intervention.

  19. The changing face of complicated infantile hemangioma treatment

    Energy Technology Data Exchange (ETDEWEB)

    Menapace, Deanna [Creighton University School of Medicine, Phoenix Regional Campus, Phoenix, AZ (United States); Mayo School of Graduate Medical Education-MN, Department of Otorhinolaryngology, Rochester, MN (United States); Mitkov, Mario [Creighton University School of Medicine, Phoenix Regional Campus, Phoenix, AZ (United States); Towbin, Richard [Phoenix Children' s Hospital, Department of Radiology, Phoenix, AZ (United States); Hogeling, Marcia [University of California, Los Angeles, Division of Dermatology, Santa Monica, CA (United States)

    2016-10-15

    Infantile hemangiomas are the most common vascular tumors of infancy. A multidisciplinary approach including dermatologists, otolaryngologists, plastic surgeons, hematologists/oncologists and interventional/diagnostic radiologists is crucial for appropriate management of children with complicated infantile hemangiomas. Since its unforeseen discovery in 2008, propranolol has become the first-line treatment for infantile hemangiomas, eclipsing systemic corticosteroids and radiologic intervention. There are still, however, uncommon indications for more aggressive interventional management. We review the 2014-updated International Society for the Study of Vascular Anomalies (ISSVA) classification for vascular anomalies. Additionally, we suggest management algorithms for complicated lesions, including recommendations for radiologic and surgical intervention. (orig.)

  20. Propranolol therapy for infantile hemangioma: our experience

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    Zhang L

    2017-05-01

    Full Text Available Ling Zhang,1,* Hai-Wei Wu,1,* Weien Yuan,2 Jia-Wei Zheng1 1Department of Oral-Maxillary Head and Neck, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People’s Republic of China *These authors contributed equally to this work Objective: Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a subset of IHs, which develop complications resulting in ulceration, bleeding, or aesthetic deformity. The primary treatment for this subset of IHs is pharmacological intervention, and propranolol has become the new first-line treatment for complicated hemangiomas. Here, we evaluated the efficacy of propranolol on proliferation IH in a clinical cohort including 578 patients.Methods: We retrospectively reviewed a total of 578 IH patients who were treated with oral propranolol from January 2010 to December 2012. Responses to the propranolol treatment were graded as: excellent, good, poor, or no response. Based on the response to propranolol treatment (once daily at a dose of 1.0 mg/kg for patients younger than 2 months; twice daily at daily total dose of 2 mg/kg for patients older than 2 months, additional pharmacotherapies or surgery were used for IH patients for satisfactory clinical outcome.Results: Five hundred and sixty (96.9% of 578 IH patients in our study responded to oral propranolol treatment, and the response rate was significantly different for different ages of patients (P<0.05, with the youngest patients having the highest response rate. The mean time of treatment was 6 months (range, 3–12 months. For example, response rate to propranolol was 98.1% in patients younger than 2 months, compared with

  1. Actualización en el tratamiento del hemangioma infantil

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    Milagros Danieyis Dorrego Oduardo

    Full Text Available Los hemangiomas en la infancia representan el tumor benigno más común. Un porcentaje significativo de estas lesiones es asociado con morbilidad sustancial en la infancia y la niñez. Se realiza una revisión bibliográfica con el fin de profundizar y ampliar los conocimientos sobre el diagnóstico y el tratamiento actualizado del hemangioma infantil. El diagnóstico de los hemangiomas es fundamentalmente clínico. Su cuadro es raramente confundible con otras lesiones. Sin embargo, en ocasiones los hemangiomas profundos pueden presentar problemas de diagnóstico diferencial con otras tumoraciones azuladas en esta localización. Los ß-bloqueantes constituyen el tratamiento de elección de los HI. Aunque se han descrito efectos secundarios aislados, se puede afirmar que es un tratamiento seguro en la edad pediátrica.

  2. Evolving strategy in treatment of infantile hemangiomas: from steroids to propranolol

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    Serhan Kupeli

    2016-06-01

    Full Text Available Infantile hemangiomas are the most common vascular tumors of the early childhood. Increased incidence of infantile hemangiomas can be attributed to widespread use of assisted reproductive technologies. Majority of hemangiomas in infantile age group resolve spontaneously and only a small proportion of the cases with infantile hemangiomas requires treatment. GLUT-ONE acronym (Giant infantile hemangiomas, Liver and/or other visceral organ involvement, Ulcerated or bleeding infantile hemangiomas, Threatening of life, Organ dysfunctioning infantile hemangiomas, Non-localized infantile hemangiomas, Esthetic/cosmetic compromise can help clinicians for the rapid decision of treatment. Corticosteroids have long been the mainstay treatment for hemangiomatous lesions but after the description of antiproliferative effect of propranolol on severe infantile hemangiomas in 2008, propranolol has been the preferred choice of treatment in many centers. Future studies should be directed to answer the questions regarding the optimal duration of propranolol treatment to overcome recurrences and clinical and histopathological characteristics of infantile hemangiomas that failed treatment with propranolol. [Cukurova Med J 2016; 41(2.000: 354-359

  3. Expression of HES and HEY genes in infantile hemangiomas.

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    Adepoju, Omotinuwe; Wong, Alvin; Kitajewski, Alex; Tong, Karen; Boscolo, Elisa; Bischoff, Joyce; Kitajewski, Jan; Wu, June K

    2011-08-11

    Infantile hemangiomas (IHs) are the most common benign tumor of infancy, yet their pathogenesis is poorly understood. IHs are believed to originate from a progenitor cell, the hemangioma stem cell (HemSC). Recent studies by our group showed that NOTCH proteins and NOTCH ligands are expressed in hemangiomas, indicating Notch signaling may be active in IHs. We sought to investigate downstream activation of Notch signaling in hemangioma cells by evaluating the expression of the basic HLH family proteins, HES/HEY, in IHs. HemSCs and hemangioma endothelial cells (HemECs) are isolated from freshly resected hemangioma specimens. Quantitative RT-PCR was performed to probe for relative gene transcript levels (normalized to beta-actin). Immunofluorescence was performed to evaluate protein expression. Co-localization studies were performed with CD31 (endothelial cells) and NOTCH3 (peri-vascular, non-endothelial cells). HemSCs were treated with the gamma secretase inhibitor (GSI) Compound E, and gene transcript levels were quantified with real-time PCR. HEY1, HEYL, and HES1 are highly expressed in HemSCs, while HEY2 is highly expressed in HemECs. Protein expression evaluation by immunofluorescence confirms that HEY2 is expressed by HemECs (CD31+ cells), while HEY1, HEYL, and HES1 are more widely expressed and mostly expressed by perivascular cells of hemangiomas. Inhibition of Notch signaling by addition of GSI resulted in down-regulation of HES/HEY genes. HES/HEY genes are expressed in IHs in cell type specific patterns; HEY2 is expressed in HemECs and HEY1, HEYL, HES1 are expressed in HemSCs. This pattern suggests that HEY/HES genes act downstream of Notch receptors that function in distinct cell types of IHs. HES/HEY gene transcripts are decreased with the addition of a gamma-secretase inhibitor, Compound E, demonstrating that Notch signaling is active in infantile hemangioma cells.

  4. Hemangioma infantil : clínica fisiopatologia e tratamento

    OpenAIRE

    Pestana, Maria Nicole Nunes

    2013-01-01

    Trabalho final de mestrado integrado em Medicina (Dermatologia), apresentado à Faculdade de Medicina da Universidade de Coimbra O hemangioma infantil (HI) é o tumor cutâneo mais frequente nas crianças. Este resulta da proliferação de células endoteliais imaturas e ao contrário de outros tumores surge após o nascimento e involui espontaneamente na maioria dos casos. O presente artigo de revisão foi feito com base numa pesquisa bibliográfica acerca de vários temas relacionados com esta pa...

  5. Critical infantile hepatic hemangioma: results of a nationwide survey by the Japanese Infantile Hepatic Hemangioma Study Group.

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    Kuroda, Tatsuo; Kumagai, Masaaki; Nosaka, Shunsuke; Nakazawa, Atsuko; Takimoto, Tetsuya; Hoshino, Ken

    2011-12-01

    The current survey aimed to describe the clinical features of critical infantile hepatic hemangioma (IHH) and the implications of recent treatments. A nationwide survey of critical IHH patients treated between 2005 and 2010 was performed in all 117 registered pediatric surgical hospitals in Japan. As a result, 19 patients were identified and reviewed using a statistical analysis. Abdominal distention (47.4%), high-output cardiac failure (47.4%), coagulopathy (42.1%), and respiratory distress (31.6%) were the major symptoms. Three patients died (1 of coagulopathy, 1 of cardiac failure, and 1 of both). An accompanying portovenous shunt was also highlighted. Infantile hepatic hemangioma was totally insensitive to steroid treatment in 3 (23.1%) of the 13 patients, and 9 (47.4%) of the 19 patients required other treatments. Surgical resection and β-blocker improved the hematologic data, whereas hepatic arterial ligation and embolization seemed to produce a limited effect. Among the dead patients, several hematologic parameters were significantly worse: the thrombocyte count (pretherapeutic: 73,000 vs 300,000/mm(3), dead vs survivor, respectively [P < .03]; posttherapeutic: 66,000 vs 388,700/mm(3) [P < .003]) and the prothrombin time (posttherapeutic, 35.0 vs 12.1 seconds [P < .0001], dead vs survivor, respectively). For critical IHH cases with steroid-insensitive hematologic disorders, alternative treatments including β-blocker therapy, surgery, and liver transplantation should be considered. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells.

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    Greenberger, Shoshana; Boscolo, Elisa; Adini, Irit; Mulliken, John B; Bischoff, Joyce

    2010-03-18

    Corticosteroids are commonly used to treat infantile hemangioma, but the mechanism of action of this therapy is unknown. We investigated the effect of corticosteroids in a previously described in vivo model of infantile hemangioma and in cultured hemangioma-derived cells. We tested hemangioma-derived stem cells for vasculogenic activity in vivo after implantation into immune-deficient (nude) mice. We studied dexamethasone treatment of both the cells before implantation and the mice after implantation. We also tested hemangioma-derived stem cells for expression of vascular endothelial growth factor A (VEGF-A) in vitro and studied the inhibition of VEGF-A expression, using short hairpin RNA (shRNA) in vivo and in vitro. Systemic treatment with dexamethasone led to dose-dependent inhibition of tumor vasculogenesis in the murine model. Pretreatment of hemangioma-derived stem cells in vitro before implantation also inhibited vasculogenesis. Dexamethasone suppressed VEGF-A production by hemangioma-derived stem cells in vitro but not by hemangioma-derived endothelial cells or human umbilical-vein endothelial cells. Silencing VEGF-A in hemangioma-derived stem cells reduced vasculogenesis in vivo. VEGF-A was detected in hemangioma specimens in the proliferating phase but not in the involuting phase and was shown by immunostaining to reside outside of vessels. Corticosteroid treatment suppressed other proangiogenic factors in hemangioma-derived stem cells, including urokinase plasminogen activator receptor, interleukin-6, monocyte chemoattractant protein 1, and matrix metalloproteinase 1. In a murine model, dexamethasone inhibited the vasculogenic potential of stem cells derived from human infantile hemangioma. The corticosteroid also inhibited the expression of VEGF-A by hemangioma-derived stem cells, and silencing of VEGF-A expression in these cells inhibited vasculogenesis in vivo. 2010 Massachusetts Medical Society

  7. Propranolol versus corticosteroids: what should be the treatment of choice in infantile hemangiomas?

    NARCIS (Netherlands)

    Theunissen, Carla I. J. M.; Smitt, J. Henk Sillevis; van der Horst, Chantal M. A. M.

    2015-01-01

    Infantile hemangiomas (IHs) are common and benign vascular tumors and usually involute spontaneously. Nevertheless, in some cases, treatment with systemic corticosteroids or propranolol is required. No randomized controlled studies, in which both treatment options were compared, have been performed.

  8. Integrative meta-analysis identifies microRNA-regulated networks in infantile hemangioma.

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    Bertoni, Natália; Pereira, Lied M S; Severino, Fábio E; Moura, Regina; Yoshida, Winston B; Reis, Patricia P

    2016-01-15

    Hemangioma is a common benign tumor in the childhood; however our knowledge about the molecular mechanisms of hemangioma development and progression are still limited. Currently, microRNAs (miRNAs) have been shown as gene expression regulators with an important role in disease pathogenesis. Our goals were to identify miRNA-mRNA expression networks associated with infantile hemangioma. We performed a meta-analysis of previously published gene expression datasets including 98 hemangioma samples. Deregulated genes were further used to identify microRNAs as potential regulators of gene expression in infantile hemangioma. Data were integrated using bioinformatics methods, and genes were mapped in proteins, which were then used to construct protein-protein interaction networks. Deregulated genes play roles in cell growth and differentiation, cell signaling, angiogenesis and vasculogenesis. Regulatory networks identified included microRNAs miR-9, miR-939 and let-7 family; these microRNAs showed the most number of interactions with deregulated genes in infantile hemangioma, suggesting that they may have an important role in the molecular mechanisms of disease. Additionally, results were used to identify drug-gene interactions and druggable gene categories using Drug-Gene Interaction Database. We show that microRNAs and microRNA-target genes may be useful biomarkers for the development of novel therapeutic strategies for patients with infantile hemangioma. microRNA-regulated pathways may play a role in infantile hemangioma development and progression and may be potentially useful for future development of novel therapeutic strategies for patients with infantile hemangioma.

  9. Estrogen-mediated hemangioma-derived stem cells through estrogen receptor-α for infantile hemangioma

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    Zhang L

    2017-07-01

    Full Text Available Ling Zhang,1 Hai Wei Wu,1 Weien Yuan,2 Jia Wei Zheng1 1Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People’s Republic of China Background: Infantile hemangiomas (IHs are the most common benign vascular tumor of infancy. They occur more frequently in female infants. The cause of hemangioma is currently unknown; however, current studies suggested the importance of estrogen (E2 signaling in hemangioma proliferation. Methods: Hemangioma-derived stem cells (HemSCs were cultured with estrogen for 48–72 h; the cell viability and proliferation were evaluated with the messenger RNA (mRNA and protein expression levels of fibroblast growth factor 2 (FGF2, vascular endothelial growth factor-A (VEGF-A and estrogen receptor-α (ER-α, by application of several in vitro assays, such as methyl thiazolyl tetrazolium (MTT, reverse transcriptase–polymerase chain reaction (RT-PCR, real-time PCR, enzyme-linked immunosorbent assay (ELISA and Western blotting. Also, the cell population’s response to external estrogen was investigated by in vivo experiments. HemSCs and human umbilical vein endothelial cells (HUVECs were mixed and injected subcutaneously into 20 flank of BALB/c-nu mice, which were randomly divided into 5 groups based on different E2 treatment doses (0, 0.01, 0.1 and 1 mg, respectively, 0.1 mg dimethyl sulfoxide (DMSO as control. Each group of mice were treated intramuscularly every week, then 2 and 4 weeks later, the subcutaneous implants were harvested and evaluated the tumor tissues with microvessel density (MVD assay and immunohistochemistry. Results: The study demonstrated that application of E2 increased the expression of FGF2, VEGF-A, and ER-α in HemSCs with the optimal concentration from 10−9 to 10−5 M. Two

  10. A New Perspective for Infantile Hepatic Hemangioma in the Age of Propranolol: Experience at Baskent University.

    Science.gov (United States)

    Sarıalioğlu, Faik; Yazıcı, Nalan; Erbay, Ayşe; Boyvat, Fatih; Demir, Şenay; Özçay, Figen; Uslu, Nihal

    2017-03-01

    Propranolol was first used in 2008 to treat hemangioma; its efficacy and safety have since changed the classical treatment indications. Infantile hepatic hemangioma presents as a spectrum of clinical conditions varying from simple asymptomatic lesions to lethal complications. Tufted hemangioma and Kaposiform hemangioendothelioma are congenital vascular tumors that lead to Kasabach-Merritt syndrome. Hemangiomas, like pure arteriovenous malformations, can cause hyperdynamic heart failure, and diffuse nodular-type hemangiomas can present with hypothyroidism. Respiratory problems and hepatic failure can be associated with diffuse nodular-type liver hemangiomas. There is a spectrum of approaches to management, varying from "watchful waiting" to liver transplant. In the age of propranolol, there has been a prominent change in the infantile hepatic hemangioma treatment algorithm. Our suggestion is early treatment with 3 mg/kg/day propranolol plus 1.0 to1.5 mg/kg/day prednisolone in all patients. This protocol is the most effective strategy for type 3 infantile hepatic hemangioma. Approximately one-third of patients with abdominal compartment syndrome in the era before propranolol treatment required liver transplant; this new treatment obviates transplant for many of these patients.

  11. The Effectiveness of Contact Cryotherapy in Treatment of Infantil Hemangiomas - Original Article

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    Nazan Taşlıdere

    2008-12-01

    Full Text Available Objective: Hemangiomas of infancy are the most common benign tumours of childhood. Cryotherapy is a widely accepted modality for the treatment of hemangiomas of the newborn. However, no studies clearly supporting its effectivity are available. In contrast to an earlier "wait and see" approach to treating hemangiomas in young children, we sought to determine whether these vascular lesions would respond to contact cryosurgery.Methods: Nineteen patients with 25 infantil hemangiomas were included in the study between 2003-2008 years. Patients were treated with contact cryotherapy. All lesions were treated with the same method (double freeze-thaw cycle of 15 seconds.Results: In 15 lesion; 11 (%73.3 lesions healed with full regression, two (%13.3 lesions healed with partially regression, one lession showed no change and one lesion showed progression. Conclusion: Contact cryotherapy has been evaluated as an effective and safe method in infantil hemangiomas.

  12. Efficacy of propranolol treatment in thyroid dysfunction associated with severe infantile hepatic hemangioma.

    Science.gov (United States)

    Vergine, Gianluca; Marsciani, Alberto; Pedini, Annalisa; Brocchi, Silvia; Marsciani, Martino; Desiderio, Elena; Bertelli, Sara; Vecchi, Vico

    2012-01-01

    Infantile hepatic hemangioma can be associated to consumptive hypothyroidism due to overexpression of type 3 deiodinase in the endothelium of vascular tumor, which catalyzes the conversion of T4 to reverse T3 (rT3) and of T3 to T2, both of which are biologically inactive. Here, we report an infant with a massive biopsy-proven infantile hepatic hemangioma who developed thyroid dysfunction without a typical biochemical profile consistent with severe consumptive hypothyroidism, despite the large tumor burden. Our patient was treated with propranolol that rapidly resolved both hepatic hemangioma and thyroid dysfunction. We propose propranolol as a first-line therapy of thyroid dysfunction associated with infantile hepatic hemangioma, in order to avoid interference with neurological development caused by hypothyroidism in the first months of life. Copyright © 2012 S. Karger AG, Basel.

  13. Propranolol Targets Contractility of Infantile Hemangioma-derived Pericytes

    Science.gov (United States)

    Lee, D.; Boscolo, E.; Durham, J.T.; Mulliken, J.B.; Herman, I.M.; Bischoff, J.

    2014-01-01

    Propranolol, a β-adrenergic receptor (AR) antagonist, was discovered serendipitously to be an effective treatment for endangering infantile hemangioma (IH). Dramatic fading of cutaneous color is often seen a short time after initiating propranolol therapy, with accelerated regression of IH blood vessels discerned after weeks to months. Here we focus on hemangioma-derived pericytes (HemPericytes) isolated from proliferating and involuting phase tumors to assess a possible role for these cells in the apparent propranolol-induced vasoconstriction. HemPericytes express high levels of β2 AR mRNA, compared to positive control bladder smooth muscle cells. In addition, β2 AR mRNA levels were relatively high in IH specimens (n=15) compared to β1 AR, β3 AR and α1bAR. HemPericytes were assayed for contractility on a deformable silicone substrate: propranolol (10μM) restored basal contractile levels in HemPericytes that were relaxed with the AR agonist epinephrine. siRNA knockdown β2 AR blunted this response. Normal human retinal and placental pericytes were not affected by epinephrine or propranolol in this assay. Propranolol (10μM) inhibited proliferation of HemPericytes in vitro, as well as normal pericytes, indicating a non-selective effect in this assay. HemPericytes and HemEC were co-implanted subcutaneously in nude mice to form blood vessels, and at day 7 after injection, mice were randomized into vehicle and propranolol treated groups. Contrast-enhanced micro-ultrasonography of the implants after 7 days of treatment showed significantly decreased vascular volume in propranolol-treated animals, but no reduction in vehicle-treated animals. These findings suggest that the mechanism of propranolol's effect on proliferating IH involves increased pericytic contractility. PMID:24720697

  14. Expression of Cathepsins B, D and G in Infantile Hemangioma

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    Tinte eItinteang

    2015-06-01

    Full Text Available Aims: The role of the renin-angiotensin system (RAS in the biology of infantile hemangioma (IH represents an emerging paradigm, particularly the involvement of renin, angiotensin converting enzyme and angiotensin II. This study investigated the expression of cathepsins B, D and G, enzymes that may modulate the RAS, in IH.Materials and Methods: The expression of cathepsins B, D and G was examined using immunohistochemistry, enzyme activity assays, mass spectrometry and Nanostring gene expression assay in IH samples at different phases of development.Results: Immunohistochemical staining showed the expression of cathepsins B, D and G in proliferating and involuted IH samples. This was confirmed at the transcriptional level using Nanostring gene expression assays. Mass spectrometry confirmed identification of cathepsins D and G in all three phases of IH development, whereas cathepsin B was detected in 2/2 proliferating and 1/2 involuting lesions. Enzyme activity assays demonstrated the activity of cathepsins B and D, but not G, in all phases of IH development.Conclusions: Our data demonstrated the presence of cathepsins B, D and G in IH. Their role in modulating the RAS and the biology of IH offers potential novel targets for the management of this tumor.

  15. Infantile hemangioma status by dynamic infrared thermography: A preliminary study.

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    Burkes, Shoná A; Patel, Manish; Adams, Denise M; Hammill, Adrienne M; Eaton, Kenneth P; Randall Wickett, R; Visscher, Marty O

    2016-10-01

    Infantile hemangiomas (IH) are initially warm due to increased proliferation and perfusion then involute with apoptosis and reduced perfusion. Objective quantitative evaluation of IH treatment response is essential for improving outcomes. We applied a functional imaging method, dynamic infrared (IR) thermography, to investigate IH status versus control skin and over time. A preliminary prospective observational study was conducted among 25 subjects with superficial or mixed IHs (thermography. Outcomes included areas under the curve during cooling (AUCcool ) and rewarming (AUCrw ) and thermal intensity distribution maps. AUCcool and AUCrw were significantly higher and cooling rate slower for IHs versus uninvolved tissue indicating greater heat, presumably due to greater perfusion and metabolism for the IH. IR distribution maps showed specific areas of high and low temperature. Significant changes in IH thermal activity were reflected in the difference (AUCcool - AUCrw ), with 6.2 at 2.2 months increasing to 37.6 at 12.8 months. IH cooling rate increased with age, indicating slower recovery, and interpreted as reduced proliferation and/or involution. Dynamic IR thermography was a well-tolerated, quantitative functional imaging modality appropriate for the clinic, particularly when structural changes, i.e., height, volume, color, were not readily observed. It may assist in monitoring progress, individualizing treatment, and evaluating therapies. www.clinicaltrials.gov (Identifier NCT02061735). © 2016 The International Society of Dermatology.

  16. Can Propranolol be used as the first line treatment in infantile hemangioma?

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    Yasemin Altuner Torun

    2011-03-01

    Full Text Available Hemangiomas are the most common tumors of infancy. Most of them require no treatment, but treatment is needed if dramatic aesthetic, and/or functional impairment as visual or airway obstruction or ulceration arises. We reported a 6-month-old infant presented with a 6-week history of a rapidly growing cutaneus hemangioma on the right eyelid and caused visual impairment. The patient was successfully treated with the use of oral propranolol therapy. We suggest that propranolol can be considered as a first line treatment in a patient with infantil hemangioma.

  17. Excellent response of infantile orofacio-orbital hemangioma to propranolol-pictorial depiction and literature review

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    Jonathan Theodore Gondi

    2016-01-01

    Full Text Available Infantile hemangiomas (IHs are common, benign vascular tumors of infancy, with more than half affecting the head and neck region. IHs involving the lips and oral cavity can often present to the oral surgeon and the pedodontist. Till date, several doubts exist among clinicians regarding the use of propranolol to treat infantile hemangiomas in neonates and small infants, appropriate dose, treatment duration, side effects, response, and long-term follow-up. We present a 2-month-old male infant with extensive hemangioma involving the face, orbit, buccal mucosa and palate with feeding difficulties, and risk of life-threatening complications such as airway compromise, aspiration, and visual loss which showed excellent response with high-dose propranolol and had no side effects. We also reviewed literature for the mechanism of action of propranolol and possible minor and serious side effects.

  18. Oral propranolol as a new treatment for facial infantile hemangioma: case report

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    Rosane da Cruz Ferreira

    2011-06-01

    Full Text Available Hemangiomas are the most common benign tumors of infancy. Despite their self-limited course, infantile capillary hemangiomas can impair vital or sensory functions as vision and cause cosmetic deformity. The usual treatments include oral/intralesional steroids, alpha interferon, cytotoxins, pulsed dye laser and cosmetic surgery resection. These treatments are not free of multiple complications and toxic side effects. This report describes the case of a 3-month-old female baby with progressively increasing hemangioma of the left upper eyelid impinging over the visual field. The hemangioma promptly responded to low-dose oral propranolol. A clinical response was noticed few days after the beginning of the treatment, with regression to 1/4 of its original size in 45 days of treatment, and to less than 1/10 after 8 months, free of any major side effects.

  19. Management of infantile subglottic hemangioma: Laser vaporization, submucous resection, intubation, or intralesional steroids?

    NARCIS (Netherlands)

    L.J. Hoeve (Hans); G.L.E. Küppers (G. L E); C.D.A. Verwoerd (Carel)

    1997-01-01

    textabstractThe infantile subglottic hemangioma can be treated in various ways. The results of the treatment used in the Sophia Children's Hospital, intralesional steroids and intubation (IS + I), are discussed and compared with the results of other current treatment methods: CO2 laser vaporization,

  20. Expression of β-Adrenergic Receptor Subtypes in Proliferative, Involuted, and Propranolol-Responsive Infantile Hemangiomas.

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    Phillips, James D; Zhang, Haihong; Wei, Ting; Richter, Gresham T

    2017-03-01

    Propranolol hydrochloride has become the primary medical treatment for problematic infantile hemangioma; however, the expression of propranolol's target receptors during growth, involution, and treatment of hemangioma remains unclear. To measure and compare the expression of β1-, β2-, and β3-adrenergic receptors (ADBR1, ADBR2, and ADBR3, respectively) in proliferative (n = 10), involuted (n = 11), and propranolol-responsive (n = 12) hemangioma tissue. Infantile hemangioma specimens were harvested for molecular investigation. Messenger RNA (mRNA) expression of the ADBR1, ADBR2, and ADBR3 genes was detected by real-time polymerase chain reaction. Protein level expression was measured by Western blot and standardized with densitometry. A total of 33 specimens were collected from patients in a tertiary pediatric hospital who underwent excision of problematic hemangiomas. This study was conducted from January 18, 2011, to September 24, 2013, and data analysis was performed from February 25, 2015, to June 25, 2016. Of the 33 patients included, 21 were female (64%). The mean (SD) patient age at the time of excision was 7 (2.5) months for the proliferative group lesions, 23.5 (10) months for the involuted group, and 16 (10) months for the propranolol group. The mean level of ADBR1 mRNA expression was significantly higher in proliferative hemangioma than in propranolol-responsive hemangioma (1.05 [0.56] vs 0.52 [0.36]; P = .01; 95% CI, 0.12-0.94). There was no difference in ADBR2 expression among the groups. Protein expression of ADBR3 was significantly higher in involuted (0.64 [0.12] vs 0.26 [0.04]; P propranolol-responsive hemangioma (0.66 [0.31] vs 0.26 [0.04]; P = .01; 95% CI, 0.16-0.68) compared with proliferative hemangioma. These data demonstrate the variable expression of ADBR subtypes among infantile hemangiomas during growth, involution, and response to treatment. These findings may have clinical implications regarding the use of

  1. Is cardiovascular evaluation necessary prior to and during beta-blocker therapy for infantile hemangiomas? : A cohort study

    NARCIS (Netherlands)

    Raphaël, Martine F.; Breugem, Corstiaan C; Vlasveld, Florine A E; de Graaf, Marlies; Slieker, Martijn G; Pasmans, Suzanne G M A; Breur, Johannes M P J Breur

    2015-01-01

    BACKGROUND: Although consensus guidelines for pretreatment evaluation and monitoring of propranolol therapy in patients with infantile hemangiomas (IH) have been formulated, little is known about the cardiovascular side effects. OBJECTIVES: We sought to analyze cardiovascular evaluations in patients

  2. Therapeutic superiority of combined propranolol with short steroids course over propranolol monotherapy in infantile hemangioma.

    Science.gov (United States)

    Aly, Mohamed M D; Hamza, Alaa F; Abdel Kader, Hesham M; Saafan, Hatem A; Ghazy, Mohamed S; Ragab, Iman A

    2015-11-01

    Infantile hemangiomas are the most common benign childhood tumor that may have functional and/or cosmetic complications. We aimed to compare the clinical efficacy of propranolol alone and propranolol primed with systemic corticosteroids on the outcome of infantile hemangioma. A prospective randomized study included 40 infants aged less than 9 months with cutaneous hemangiomas. Patients were randomly assigned into two groups: group A were given oral prednisolone for the initial 2 weeks combined with oral propranolol, while group B were given oral propranolol alone for 6 months. The median age of the studied patients was 4.5 months (ranged 4 weeks-8 months). Sequential determination of the dimensions of the hemangiomas based on direct measurement and photographic analysis were performed. A significant reduction in the size of the lesions was found in group A in the 2-, 4-, and 8-week evaluation compared to group B (p propranolol and prednisolone (OR 10.71, p = 0.006) were the predictors of best response. Combining propranolol with corticosteroids gives a faster response and should be considered in treating life- or function-threatening hemangiomas.

  3. Social Impact of Facial Infantile Hemangiomas in Preteen Children.

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    Costa, Victoria A; Haimowitz, Rachel; Cheng, Yao I; Wang, Jichuan; Silverman, Robert A; Bauman, Nancy M

    2016-01-01

    Involuted infantile facial hemangiomas (IHs) may adversely affect the social skills of children. To assess the social impact of involuted facial IHs, with or without prior treatment, in preteen children. An observational, cross-sectional study of social anxiety and skills in preteen children with facial IHs diagnosed during infancy. The study took place in an academic institution and a community dermatology practice between January 1, 2013, and July 30, 2014. Records on 236 children with IHs located in a cosmetically sensitive area were identified; of those, 144 potential participants (parents) were reached by telephone and mailed study packets. Thirty completed questionnaires were returned. Data analysis was performed from August 1, 2014, to September 7, 2015. The questionnaires included the following psychiatric scales: (1) Social Anxiety Scale for Children-Revised (SASC-R), completed by parents and children, including the domains of Fear of Negative Evaluation and Social Avoidance/Distress in New Situations (SAD-New) (higher scores indicate greater social anxiety), and (2) Social Competency Inventory (SCI), completed by parents, including the domains of Prosocial Behavior and Social Initiative (lower scores indicate poorer social competency). Demographics, clinical details, and survey responses were collected. Analysis was conducted using t tests to compare scores for each survey domain with established normative data and between sex as well as between treatment vs nontreatment groups. Of the 144 potential participants, 30 (21%) responded. The mean age of the preteen subjects was 10.0 years (range, 5.4-12.9 years) with a 2:1 female to male ratio. Twenty-five children (83%) had a single IH, and the remaining 5 participants (17%) had multiple IHs, with at least 1 IH in a cosmetically sensitive area. The periocular region was the most common site of the IH (10 [33%]), followed by the nose (6 [20%]), cheek (5 [17%]), forehead (4 [13%]), lip or perioral region (4 [13

  4. [Usage and efficacy of timolol maleate eye drops in treatment of superficial infantile hemangioma].

    Science.gov (United States)

    Wu, Qizhen; Shi, Qingmei; Long, Jianhong; Li, Jiaguang; Guo, Yu; Lei, Shaorong

    2017-06-28

    To determine drug dose and usage of timolol maleate eye drops in the treatment of superficial infantile hemangioma.
 Methods: A total of 250 superficial hemangioma infants were recruited and assigned into 5 groups (n=50 for each group): an external application group and 4 exterior coating groups (2, 4, 6, 8 times per day). We evaluated the therapeutic effect of different methods for drug application (external application or exterior coating) and the frequency for drug administration on superficial infantile hemangioma.
 Results: The external application group (twice a day and 0.5 hour per time) showed better effect than that in the exterior coating group with twice a day (Pexterior coating group with 6 times a day and exterior coating group with twice a day or with 3 times a day was significant (Pexterior coating group with 6 times a day, the exterior coating group with 8 times a day, or the external application group with twice a day (All P>0.05).
 Conclusion: Drug dose may affect the therapeutic effect of timolol maleate eye drops in superficial hemangioma infants, and exterior coating with 6 times a day may achieve the best curative effect.

  5. Infantile hemangioma: pulsed dye laser versus surgical therapy

    Science.gov (United States)

    Remlova, E.; Dostalova, T.; Michalusova, I.; Vranova, J.; Jelinkova, H.; Hubacek, M.

    2014-05-01

    Hemangioma is a mesenchymal benign tumor formed by blood vessels. Anomalies affect up to 10% of children and they are more common in females than in males. The aim of our study was to compare the treatment efficacy, namely the curative effect and adverse events, such as loss of pigment and appearance of scarring, between classical surgery techniques and laser techniques. For that reason a group of 223 patients with hemangioma was retrospectively reviewed. For treatment, a pulsed dye laser (PDL) (Rhodamine G, wavelength 595 nm, pulsewidth between 0.45 and 40 ms, spot diameter 7 mm, energy density 9-11 J cm-2) was used and the results were compared with a control group treated with classical surgical therapy under general anesthesia. The curative effects, mainly number of sessions, appearance of scars, loss of pigment, and relapses were evaluated as a marker of successful treatment. From the results it was evident that the therapeutic effects of both systems are similar. The PDL was successful in all cases. The surgery patients had four relapses. Classical surgery is directly connected with the presence of scars, but the system is safe for larger hemangiomas. It was confirmed that the PDL had the optimal curative effect without scars for small lesions (approximately 10 mm). Surgical treatment under general anesthesia is better for large hemangiomas; the disadvantage is the presence of scars.

  6. Hemangioma

    Science.gov (United States)

    ... capillary and cavernous types. Lobular capillary hemangioma (pyogenic granuloma). These small, red bumps often appear on the hands, face, and arms. Because they contain so many blood vessels, they bleed easily — often with just mild contact. This type of hemangioma is also sometimes referred ...

  7. Psoriasiform Diaper Rash Possibly Induced by Oral Propranolol in an 18-Month-Old Girl with Infantile Hemangioma

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    Raphaëlle Baggio

    2016-12-01

    Full Text Available Propranolol, a nonselective blocker of β-adrenergic receptors, has become the first-line treatment for complicated infantile hemangiomas. Therefore, its use in the pediatric population has expanded in recent years. In adults, β-blockers have been reported to be the most common causative agents for drug-induced psoriasis. In infants treated with propranolol for infantile hemangioma, the onset of psoriasiform diaper rash has not yet been reported. Here, to the best of our knowledge, we report the first case of psoriasiform diaper rash possibly induced by oral propranolol in an 18-month-old girl with no family history of psoriasis.

  8. Hemangiomas

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    ... children can safely be weaned off the drug. Alfa-interferon is recommended for hemangiomas that do not respond ... associated in 10-12% of the children taking alfa-interferon and as a result should be used with ...

  9. Propranolol treatment for infantile hemangioma does not increase risk of childhood wheezing.

    Science.gov (United States)

    Mei-Zahav, Meir; Blau, Hannah; Hoshen, Moshe; Zvulunov, Alex; Mussaffi, Huda; Prais, Dario; Stafler, Patrick; Steuer, Guy; Lapidoth, Moshe; Amitai, Dan Ben

    2017-08-01

    Propranolol is the treatment of choice for infantile hemangiomas requiring medical intervention. Although contraindicated in asthma, its bronchoconstrictive effect in infants and children has not been extensively studied. We aimed to assess the incidence of wheezing episodes in infants and children treated with propranolol for infantile hemangiomas. A retrospective case-control study. a tertiary pediatric hospital. All Children followed for infantile hemangioma between 2009 and 2014. Children followed conservatively served as control group and were matched 1:1 for gender and month of birth by random matching to children treated with propranolol. All respiratory episodes (asthma, wheezing, stridor, and pneumonia) and respiratory associated hospitalizations were recorded from hospital records, from the primary care physician visits records and pharmacy prescriptions. The main outcome measure was the incidence of respiratory episodes in the treatment and the control groups. A total of 1828 clinic visits were reviewed for 683 children. In addition, primary care physician visits records were available in 80% of them. Two hundred and sixteen children were treated with propranolol. Incidence of respiratory episodes and recurrent respiratory episodes was similar in the propranolol and control groups (8.3% vs 12%, P = 0.265; 3.7% vs 6.5%, P = 0.274, respectively). Time to first episode was similar in the treatment and control groups (5.03 ± 3.32 vs 4.45 ± 3.21 months, respectively, P = 0.09). Respiratory hospital admission rate was similar in both groups. Propranolol treatment does not exacerbate wheezing episodes in infants and children. © 2017 Wiley Periodicals, Inc.

  10. Propranolol treatment of infantile hemangioma (IH) is not associated with developmental risk or growth impairment at age 4 years

    NARCIS (Netherlands)

    Moyakine, Andre Vadimovich; Kerstjens, Jorien Maria; Spillekom-van Koulil, Saskia; van der Vleuten, Catharina Joanna Maria

    Background: Long-term adverse effects of propranolol treatment for infantile hemangioma (IH) in young children have been suggested. Objective: To compare growth and development in children treated with propranolol for IH with nontreated healthy controls. Methods: Eighty two (73%) children with IH

  11. Comparison of intralesional corticosteroid and propranolol treatment of periorbital infantile hemangiomas: an outcome study of 61 cases

    NARCIS (Netherlands)

    Hoornweg, Marije J.; Saeed, Peerooz; Tanck, Michael W. T.; Hage, J. Joris; Coumou, Adriaan D.; van der Horst, Chantal M. A. M.

    2014-01-01

    Purpose: To compare intralesional corticosteroid (IC) injections with oral propranolol in children with periorbital infantile hemangioma (IH). Methods: Children were diagnosed with IH and treated with IC (n = 29) or propranolol (n = 14). In cases in which no further improvement was seen, treatment

  12. History of the infantile hepatic hemangioma: From imaging to generating a differential diagnosis.

    Science.gov (United States)

    Gnarra, Maria; Behr, Gerald; Kitajewski, Alison; Wu, June K; Anupindi, Sudha A; Shawber, Carrie J; Zavras, Nick; Schizas, Dimitrios; Salakos, Chris; Economopoulos, Konstantinos P

    2016-08-08

    We aim to provide an up-to-date summary of infantile hepatic hemangioma (IHH) and its misnomers and to dialectically present the differential diagnosis of these rare entities of the liver. Eligible peer-reviewed articles on hepatic infantile hemangiomas, published between 2000 and 2015, were reviewed for this study. IHH is the most common hepatic vascular tumor in children. Once a liver mass is identified in an infant, the differential diagnosis ranges from vascular malformations to benign and malignant tumors including mesenchymal hamartoma, hepatoblastoma, metastatic neuroblastoma, so careful physical examination, imaging studies, and, if indicated, tumor markers and biopsy, are of pivotal importance to ascertain the correct diagnosis. Despite the benign nature of IHHs, some of these lesions may demand medical and/or surgical intervention, especially for multiple and diffuse IHH. Complications can include hepatomegaly, hypothyroidism and cardiac failure. Therefore, a close follow-up is required until complete involution of the lesions. We propose an algorithm to guide the physicians towards the proper management of hepatic lesions.

  13. Initiation and Use of Propranolol for Infantile Hemangioma: Report of a Consensus Conference

    Science.gov (United States)

    Frommelt, Peter C.; Chamlin, Sarah L.; Haggstrom, Anita; Bauman, Nancy M.; Chiu, Yvonne E.; Chun, Robert H.; Garzon, Maria C.; Holland, Kristen E.; Liberman, Leonardo; MacLellan-Tobert, Susan; Mancini, Anthony J.; Metry, Denise; Puttgen, Katherine B.; Seefeldt, Marcia; Sidbury, Robert; Ward, Kendra M.; Blei, Francine; Baselga, Eulalia; Cassidy, Laura; Darrow, David H.; Joachim, Shawna; Kwon, Eun-Kyung M.; Martin, Kari; Perkins, Jonathan; Siegel, Dawn H.; Boucek, Robert J.; Frieden, Ilona J.

    2013-01-01

    Infantile hemangiomas (IHs) are common neoplasms composed of proliferating endothelial-like cells. Despite the relative frequency of IH and the potential severity of complications, there are currently no uniform guidelines for treatment. Although propranolol has rapidly been adopted, there is significant uncertainty and divergence of opinion regarding safety monitoring, dose escalation, and its use in PHACE syndrome (PHACE = posterior fossa, hemangioma, arterial lesions, cardiac abnormalities, eye abnormalities; a cutaneous neurovascular syndrome characterized by large, segmental hemangiomas of the head and neck along with congenital anomalies of the brain, heart, eyes and/or chest wall). A consensus conference was held on December 9, 2011. The multidisciplinary team reviewed existing data on the pharmacologic properties of propranolol and all published reports pertaining to the use of propranolol in pediatric patients. Workgroups were assigned specific topics to propose protocols on the following subjects: contraindications, special populations, pretreatment evaluation, dose escalation, and monitoring. Consensus protocols were recorded during the meeting and refined after the meeting. When appropriate, protocol clarifications and revision were made and agreed upon by the group via teleconference. Because of the absence of high-quality clinical research data, evidence-based recommendations are not possible at present. However, the team agreed on a number of recommendations that arose from a review of existing evidence, including when to treat complicated IH; contraindications and pretreatment evaluation protocols; propranolol use in PHACE syndrome; formulation, target dose, and frequency of propranolol; initiation of propranolol in infants; cardiovascular monitoring; ongoing monitoring; and prevention of hypoglycemia. Where there was considerable controversy, the more conservative approach was selected. We acknowledge that the recommendations are conservative in

  14. Imaging findings of multiple infantile hepatic hemangioma associated with cardiac insufficiency.

    Science.gov (United States)

    Ye, Jing-Jing; Shao, Yin-Can; Shu, Qiang

    2014-11-01

    Infantile hepatic hemangioma (IHH) as a benign liver tumor in infancy and childhood is commonly associated with high output cardiac failure. The present study aims to describe the imaging findings in a patient who was diagnosed as having multiple IHH with congestive cardiac insufficiency. The imaging findings and clinical manifestations of the patient with multiple IHH associated with cardiac insufficiency were retrospectively reviewed. Ultrasonography showed multiple intrahepatic lesions with mixed echoes and markedly expanded hepatic veins and the inferior vena cava of the patient. Echocardiography revealed right heart insufficiency and pulmonary hypertension. Contrast-enhanced MRI showed early mild enhancement of lesions and more obvious delayed enhancement. The patient died after combined therapy of surgery and hormone. The imaging findings of multiple IHH associated with cardiac insufficiency are typical and diagnostic. Early imaging assessment may facilitate the diagnosis and treatment of the disease.

  15. Propranolol in Treatment of Huge and Complicated Infantile Hemangiomas in Egyptian Children

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    Basheir A. Hassan

    2014-01-01

    Full Text Available Background. Infantile hemangiomas (IHs are the most common benign tumours of infancy. Propranolol has recently been reported to be a highly effective treatment for IHs. This study aimed to evaluate the efficacy and side effects of propranolol for treatment of complicated cases of IHs. Patients and Methods. This prospective clinical study included 30 children with huge or complicated IHs; their ages ranged from 2 months to 1 year. They were treated by oral propranolol. Treatment outcomes were clinically evaluated. Results. Superficial cutaneous hemangiomas began to respond to propranolol therapy within one to two weeks after the onset of treatment. The mean treatment period that was needed for the occurrence of complete resolution was 9.4 months. Treatment with propranolol was well tolerated and had few side effects. No rebound growth of the tumors was noted when propranolol dosing stopped except in one case. Conclusion. Propranolol is a promising treatment for IHs without obvious side effects. However, further studies with longer follow-up periods are needed.

  16. Effectiveness and Safety of Oral Propranolol versus Other Treatments for Infantile Hemangiomas: A Meta-Analysis

    Science.gov (United States)

    Liu, Xiaohan; Qu, Xinhua; Zheng, Jiawei; Zhang, Ling

    2015-01-01

    Background Epidemiological studies evaluating treatments for infantile hemangiomas have produced inconsistent results. A meta-analysis of published data was conducted to investigate the effectiveness and safety of oral propranolol versus other treatments for infantile hemangiomas. Methods A meta-analysis was conducted based on literature (published from 1960 to December 1, 2014) found on the PubMed, EMBASE, and OVID search engines. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the outcome measures. Heterogeneity, publication bias and subgroup analysis were performed. Results A total of 61 studies involving 5,130 participants met the inclusion criteria. Propranolol was found to be a more effective modality in treating IHs (ORs = 0.92; 95%CI, 0.89–0.95) and had fewer complications compared to the other treatments including systemic steroids (ORs = 0.68; 95% CI, 0.59–0.76); laser ablation (ORs = 0.55; 95% CI, 0.43–0.67); other beta-adrenergic blockers (ORs = 0.56; 95% CI, 0.50–0.61) and surgery (ORs = 0.55; 95% CI, 0.28–0.81). A subgroup analysis of propranolol showed that a dose of 2 mg/kg/day or more yielded better outcomes (ORs = 0.92; 95% CI, 0.88–0.95; ORs = 0.95; 95% CI, 0.89–1.00), and IHs that had not been previously treated had better responses to propranolol treatment (ORs = 0.95; 95% CI, 0.91–0.98). Conclusions The meta-analysis demonstrated that propranolol was more effective and safer than other therapies in treating IHs. It provides strong evidence for supporting the use of propranolol as a first-line therapy for IHs. PMID:26375455

  17. Presentación de 3 casos de hemangiomas infantiles tratados con propranolol Presentation of three cases of infantile hemangiomata treated with propranolol

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    Edelisa Moredo Romo

    2011-09-01

    Full Text Available Los hemangiomas infantiles son los tumores vasculares benignos más frecuentes en la infancia, que ocurren mayormente en los pacientes pretérmino y en un 80 % afectan cabeza y cuello, con serias complicaciones hasta en un 20 % de los pacientes. Su ritmo evolutivo se caracteriza por una fase proliferativa y otra involutiva que pueden durar años. En la actualidad han sido utilizados los betabloqueadores, como el propranolol oral, con muy buenos resultados. Presentamos una serie de 3 casos de pacientes con hemangioma infantil atendidos en consulta de dermatología del Hospital Pediátrico Docente "Juan Manuel Márquez", tratados con propranolol de producción nacional por vía oral a 2 mg/kg/d en 2 subdosis con muy buenos resultados.The infantile hemangiomata are the benign vascular tumors more frequent in childhood occurring mainly in pre-term patients and in a 80 % involve the head and the neck with serious complications up to a 20 % of patients. Its evolution rhythm is characterized by a proliferative phase and another involutional that may be present for years. Nowadays, the beta-blockers have been used, e.g. the oral propranolol with very good results. This is the presentation of three cases with infantile hemangioma seen in the dermatology consultation from the "Juan Manual Márquez" Teaching Children Hospital and treated with 2 mg/dk/d at two subdose of propranolol of national production with very good results.

  18. Analysis of the therapeutic evolution in the management of airway infantile hemangioma.

    Science.gov (United States)

    Vivas-Colmenares, Grecia V; Fernandez-Pineda, Israel; Lopez-Gutierrez, Juan Carlos; Fernandez-Hurtado, Miguel Angel; Garcia-Casillas, Maria Antonia; Matute de Cardenas, Jose Antonio

    2016-02-08

    To analyze the evolution in the management of airway infantile hemangioma (AIH) and to report the results from 3 pediatric tertiary care institutions. A retrospective study of patients with diagnosis of AIH and treated in 3 pediatric tertiary care institutions from 1996 to 2014 was performed. Twenty-three patients with diagnosis of AIH were identified. Mean age at diagnosis was 6 mo (range, 1-27). Single therapy was indicated in 16 patients and 7 patients received combined therapy. Two therapeutic groups were identified: Group A included 14 patients who were treated with steroids, interferon, laser therapy and/or surgery; group B included 9 patients treated with oral propranolol. In group A, oral corticosteroids were used in 9 patients with a good response in 3 cases (no requiring other therapeutic option), the other patients required additional treatment options. Cushing syndrome was observed in 3 patients. One patient died of a fulminant sepsis. Open surgical excision and endoscopic therapy were performed in 11 patients (in 5 of them as a single treatment) with a response rate of 54.5%. Stridor persisted in 2 cases, and one patient died during the clinical course of bronchial aspiration. In group B, oral propranolol was used in 9 patients (in 8 of them as a single treatment) with a response rate of 100%, with an mean treatment duration of 7 mo (range, 5-10); complications were not observed. Our experience and the medical literature support the use of propranolol as a first line of treatment in AIH.

  19. Propranolol for infantile hemangioma: Effect on plasma vascular endothelial growth factor.

    Science.gov (United States)

    Ozeki, Michio; Nozawa, Akifumi; Hori, Tomohiro; Kanda, Kaori; Kimura, Takeshi; Kawamoto, Norio; Fukao, Toshiyuki

    2016-11-01

    Propranolol has recently been shown to be highly effective for infantile hemangioma (IH), but the mechanism of action of propranolol and the usefulness of measurement of vascular endothelial growth factor (VEGF) remain poorly understood. The aim of this study was therefore to determine the efficacy of propranolol treatment and to evaluate changes in plasma VEGF in IH patients who underwent propranolol treatment. The study group consisted of 35 children with IH. Oral propranolol was give at a dose of 2.0 mg/kg/day and was divided in three doses. Outcome was assessed using the visual analog scale (VAS) of size and color. Plasma VEGF concentration was analyzed on enzyme-linked immunoabsorbent assay, and compared between the groups. Improvement in VAS in patients who started propranolol before 6 months of age was superior to that in those who started propranolol after 6 months of age. VEGF concentration was significantly correlated with lesion size (P = 0.002), whereas no correlation was observed with age. VEGF concentration 4 weeks after treatment was significantly lower than that before treatment (P < 0.01). Measurement of VEGF may be a useful tool for predicting the course of IH and monitoring the effectiveness of treatment. © 2016 Japan Pediatric Society.

  20. Ultrasonography as an objective tool for assessment of infantile hemangioma treatment with propranolol.

    Science.gov (United States)

    Rotter, Anita; Samorano, Luciana Paula; de Oliveira Labinas, Glaucia Helena; Alvarenga, Juliana Gobbi; Rivitti-Machado, Maria Cecília; Bouer, Márcio; Santos, Paulo C C; Silvestre, Daniel A M; de Oliveira, Zilda Najjar Prado

    2017-02-01

    Infantile hemangiomas (IHs) are the most common benign vascular tumors of childhood. Propranolol is an effective drug in treating IH. A reliable and complementary instrument is necessary to evaluate IH response to propranolol in addition to clinical and photographic assessments. Ultrasonography is a simple and non-invasive technique that enables precise measurements of tumor size and contributes to objective follow-up. To demonstrate the use of serial ultrasonography as an adjunctive tool for assessment of IH treatment with propranolol. A retrospective study of 19 patients with IH treated with propranolol was conducted from January 2009 to March 2014. Data of individual IH volume at the beginning and at least 6 months after the onset of treatment and overall volume reduction by ultrasonographic measurement were obtained. We observed a statistically significant IH volume reduction of approximately 0.51 cm3 . This volume corresponds to an average reduction of 47% in the final volume compared with the initial volume. Ultrasonographic measurements contribute to demonstrate tumor regression and IH response to propranolol. Thus, ultrasonography is an important instrument to guide therapeutic strategies. © 2016 The International Society of Dermatology.

  1. Propranolol treatment for infantile hemangioma: a case series of sixty-two patients.

    Science.gov (United States)

    Stringari, Giovanna; Barbato, Giulia; Zanzucchi, Matteo; Marchesi, Maddalena; Cerasoli, Giuseppe; Tchana, Bertrand; Gritti, Alessandro; Boccaletti, Valeria; Lombardi, Alfonsa Anna; Carano, Nicola

    2016-06-27

    Infantile hemangiomas (IH) complicated by ulceration, disfigurement, functional impairment or life-threatening conditions need early, safe and effective treatment. This study explores the impact of propranolol on complicated IH. We report our experience of 62 patients treated with oral propranolol for complicated IH. The effect of propranolol was assessed using a score on a visual analogue scale integrated with echo, magnetic resonance or endoscopic findings. The average age at the beginning of the treatment was seven months [standard deviation (SD)±8.9], with a median of four months (range 1-53 months). The average age at the end of the treatment was 15 months (SD±8.4), with a median of 13 months (range 7-59 months). The mean treatment length was eight months (SD±3.2). Oral propranolol was successful in 95.2% of the patients in reducing the volume, the intensity of color and the elevation of IH. Statistically significant improvement of IH volume was observed in the first two months of therapy (P≤0.001), and between the second month and the end of the treatment (P<0.05). No significant bradycardia or hypotension occurred. Severe hypoglycemia occurred in one patient. Mild adverse effects were observed in seven patients. Our study demonstrates that propranolol administered orally at 2 to 3 mg/kg/day has a rapid therapeutic effect leading to remarkable shortening of the natural course of IH and it is safe in the majority of patients.

  2. Assessment of the effectiveness of topical propranolol 4% gel for infantile hemangiomas.

    Science.gov (United States)

    Mashiah, Jacob; Kutz, Ana; Rabia, Smail Hadj; Ilan, Efrat Bar; Goldberg, Ilan; Sprecher, Eli; Harel, Avikam

    2017-02-01

    Infantile hemangiomas (IHs) are the most common vascular tumors in children. Because of their benign character and natural involution, the vast majority of IHs do not require any treatment. In the past few years, topical beta blockers have been reported to be an effective treatment of superficial IHs. We sought to evaluate the clinical effectiveness and safety profile of topical propranolol 4% gel for the treatment of IHs. A retrospective study of all cases of IHs treated with topical propranolol 4% gel between 2013 and 2015 was performed. All patients were evaluated in a pediatric dermatology unit of a tertiary medical center. Epidemiologic, clinical, and treatment data, including effectiveness score and safety, were reviewed. The study included 63 patients with a total of 75 IHs. Of the total number of IHs, 43 (57.3%) showed a good response to treatment, 19 (25.3%) a partial response, and 13 (17.33%) poor or no response, thus 62 (82.6%) had good or partial response to treatment. Age at treatment initiation, treatment time, thickness of the superficial component, and size of the lesions were shown to predict response to therapy. Out of the entire examined group, only two patients reported minor local side effects manifested by irritation, redness, and scaling of the treated area. No systemic adverse effects were reported. This is an uncontrolled retrospective study. Propranolol 4% gel is a safe and efficient topical therapy for IH. © 2017 The International Society of Dermatology.

  3. Propranolol versus captopril in the treatment of infantile hemangioma (IH): A randomized controlled trial.

    Science.gov (United States)

    Zaher, Hesham; Rasheed, Hoda; El-Komy, Mohamed M; Hegazy, Rehab A; Gawdat, Heba I; Abdel Halim, Dalia M; Abdel Hay, Rania M; Hegazy, Ranya A; Mohy, Abeer M

    2016-03-01

    Renin-angiotensin system components have been demonstrated in the biology of infantile hemangioma (IH). Captopril, an angiotensin-converting enzyme inhibitor, is proposed as a therapeutic alternative to oral propranolol. We sought to compare the benefit of propranolol and captopril in the treatment of IH, and to assess angiotensin-converting enzyme gene polymorphism in patients with IH and in control subjects. Thirty patients with IH and 35 healthy control subjects were enrolled in this study. Patients were randomly assigned to treatment with either propranolol or captopril. Assessment was done clinically and by measurement of serum vascular endothelial growth factor and angiotensin II in patients and control subjects. Angiotensin-converting enzyme gene polymorphism was also studied. Clinical improvement was significantly better and faster in the patients treated with propranolol. Both groups showed reduced vascular endothelial growth factor and angiotensin II levels posttreatment, with a significantly higher percentage reduction in the propranolol-treated group. Cardiac side effects were reported only in the captopril-treated group. Baseline vascular endothelial growth factor level was significantly higher, and baseline angiotensin II level was significantly lower, in patients than control subjects. We studied a relatively small number of patients and control subjects. Propranolol shows greater benefit than captopril in the treatment of IH. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  4. Atenolol versus propranolol for the treatment of infantile hemangiomas: a randomized controlled study.

    Science.gov (United States)

    Ábarzúa-Araya, Alvaro; Navarrete-Dechent, Cristián P; Heusser, Felipe; Retamal, Javiera; Zegpi-Trueba, María Soledad

    2014-06-01

    Infantile hemangiomas have a dramatic response to propranolol, a nonselective beta-blocker. However, this treatment is not risk-free and many patients are excluded because of respiratory comorbidities. Atenolol is a cardioselective beta-blocker that may have fewer adverse events. We sought to evaluate the effectiveness of atenolol against propranolol in a noninferiority trial. In all, 23 patients met the inclusion criteria and were randomized to receive either atenolol or propranolol. Thirteen patients were treated with atenolol and 10 with propranolol. Follow-up was made at baseline, 2 weeks, 4 weeks, and then monthly for 6 months. Patients treated with atenolol had a complete response of 53.8% and 60% with propranolol, respectively. These results were nonsignificant (P = .68). Relevant adverse events were not reported. The reduced number of patients could have influenced our results. Atenolol appears to be as effective as propranolol. We did not find significant differences between these results or any adverse events. Copyright © 2014 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  5. Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma

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    Hai Wei Wu

    2017-06-01

    Full Text Available The therapeutic options for infantile hemangiomas (IHs have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.5% hydrogel and treated 321 patients with superficial IHs to evaluate its efficacy and safety in the treatment of superficial IHs. This new timolol hydrogel was applied three times daily with a mean duration of 7.1 months. Response to treatment was assessed according to cosmetic improvement by using visual analog scale (VAS. The average VAS improvement after treatment was 76.4, with 126 patients (39.3% achieving excellent responses, 159 patients (49.5% achieving good responses, 33 patients (10.3% achieving fair responses, and three patients (0.9% achieving poor responses. Age at treatment initiation (P = 0.0349 and lesion thickness (P = 0.0147 were significantly associated with therapeutic efficacy. No severe side effects were observed in all patients. In conclusion, this new topical timolol maleate 0.5% hydrogel appears to be a proper candidate for treating superficial IHs, and our study provides supportive evidence and experience of topical timolol maleate in treating superficial IHs.

  6. Comparison of Efficacy and Safety Between Propranolol and Steroid for Infantile Hemangioma: A Randomized Clinical Trial.

    Science.gov (United States)

    Kim, Kyu Han; Choi, Tae Hyun; Choi, Yunhee; Park, Young Woon; Hong, Ki Yong; Kim, Dong Young; Choe, Yun Seon; Lee, Hyunjung; Cheon, Jung-Eun; Park, Jung-Bin; Park, Kyung Duk; Kang, Hyoung Jin; Shin, Hee Young; Jeong, Jae Hoon

    2017-06-01

    There are limited data from randomized clinical trials comparing propranolol and steroid medication for treatment of infantile hemangioma (IH). To determine the efficacy and safety of propranolol compared with steroid as a first-line treatment for IH. This randomized clinical noninferiority trial tested the efficacy and safety of propranolol vs steroid treatment for IH at a single academic hospital. All participants were diagnosed with IH between June 2013 and October 2014, had normal heart function, and had not been previously treated for IH. The participants were randomly assigned to either the propranolol group or the steroid group. In the propranolol group, the patients were admitted, observed for adverse effects for 3 days after treatment initiation, and then released and treated as outpatients for 16 weeks (2 mg/kg/d). In the steroid group, the patients were seen as outpatients from the beginning and were also treated for 16 weeks (2 mg/kg/d). The primary efficacy variable was the response to treatment at 16 weeks, which was evaluated by the hemangioma volume using magnetic resonance imaging before and at 16 weeks after treatment initiation. While comparing the effect of medication between the groups, we monitored the adverse effects of both drugs. A total of 34 patients (15 boys, 19 girls; mean age, 3.3 months; range, 0.3-8.2 months) were randomized to receive either propranolol or steroid treatment (17 in each treatment group). Guardians for 2 patients in the steroid group withdrew their consent, and 1 patient in the propranolol group did not complete the efficacy test. The intention-to-treat analysis, applying multiple imputations, found the treatment response rate in the propranolol group to be 95.65%, and that of the steroid group was 91.94%. Because the difference in response rate between the groups was 3.71%, propranolol was considered noninferior. We found that there was no difference between the groups in safety outcomes. Our trial demonstrated that

  7. Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins

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    Nakayama, Hironao [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Surgery, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Toon, Ehime 791-0295 (Japan); Huang, Lan [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Surgery, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Kelly, Ryan P.; Oudenaarden, Clara R.L. [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Dagher, Adelle; Hofmann, Nicole A.; Moses, Marsha A. [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Surgery, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Bischoff, Joyce, E-mail: joyce.bischoff@childrens.harvard.edu [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Surgery, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Klagsbrun, Michael, E-mail: michael.klagsbrun@childrens.harvard.edu [Vascular Biology Program, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Surgery, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States); Department of Pathology, Boston Children' s Hospital, Harvard Medical School, Boston, MA 02115 (United States)

    2015-08-14

    Class 3 semaphorins were discovered as a family of axon guidance molecules, but are now known to be involved in diverse biologic processes. In this study, we investigated the anti-angiogenic potential of SEMA3E and SEMA3F (SEMA3E&F) in infantile hemangioma (IH). IH is a common vascular tumor that involves both vasculogenesis and angiogenesis. Our lab has identified and isolated hemangioma stem cells (HemSC), glucose transporter 1 positive (GLUT1{sup +}) endothelial cells (designated as GLUT1{sup sel} cells) based on anti-GLUT1 magnetic beads selection and GLUT1-negative endothelial cells (named HemEC). We have shown that these types of cells play important roles in hemangiogenesis. We report here that SEMA3E inhibited HemEC migration and proliferation while SEMA3F was able to suppress the migration and proliferation in all three types of cells. Confocal microscopy showed that stress fibers in HemEC were reduced by SEMA3E&F and that stress fibers in HemSC were decreased by SEMA3F, which led to cytoskeletal collapse and loss of cell motility in both cell types. Additionally, SEMA3E&F were able to inhibit vascular endothelial growth factor (VEGF)-induced sprouts in all three types of cells. Further, SEMA3E&F reduced the level of p-VEGFR2 and its downstream p-ERK in HemEC. These results demonstrate that SEMA3E&F inhibit IH cell proliferation and suppress the angiogenic activities of migration and sprout formation. SEMA3E&F may have therapeutic potential to treat or prevent growth of highly proliferative IH. - Highlights: • SEMA3E&F reduce actin stress fibers and induce cytoskeletal collapse in HemEC. • SEMA3E&F inhibit angiogenic activities of HemEC. • SEMA3E&F can interrupt the VEGF-A-VEGFR2-ERK signaling pathway in HemEC. • Plexin D1 and NRP2 are induced during HemSC/GLUT1{sup sel}-to-EC differentiation.

  8. Propranolol treatment of infantile hemangioma is not associated with psychological problems at 7 years of age.

    Science.gov (United States)

    Moyakine, Andre Vadimovich; Spillekom-van Koulil, Saskia; van der Vleuten, Catharina Joanna Maria

    2017-07-01

    Concern has been raised about the potential long-term effects of propranolol treatment for infantile hemangioma (IH). We sought to assess psychologic (social, emotional, behavioral, and executive) functioning in children treated with propranolol for IH. Twenty-seven patients with IH (6.1-7.6 years of age) treated with propranolol for ≥6 months during infancy, and without other developmental risk factors, were recruited. Parents completed the Behavior Rating Inventory of Executive Function, Social Emotional Questionnaire, Child Behavior Checklist, and Strengths and Difficulties Questionnaire. For each questionnaire, the number of patients with abnormal scores, based on established cutoff points, was calculated. Only 1 child (3.7%) scored outside the normal range. The Hemangioma Severity Scale did not correlate with psychologic problems in these patients. Longer treatment duration was found to correlate with less attention-deficit hyperactivity disorder (ADHD) characteristics (ρ = -0.476; P = .012) and better executive functioning (ρ = -0.466; P = .014). Exclusion of children born at gestational age propranolol. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  9. Infrared thermography to assess proliferation and involution of infantile hemangiomas: a prospective cohort study.

    Science.gov (United States)

    Mohammed, Javed Ayoub; Balma-Mena, Alexandra; Chakkittakandiyil, Ajith; Matea, Florentina; Pope, Elena

    2014-09-01

    Infantile hemangiomas (IHs) are common benign tumors of infancy that have the potential to interfere with vital organ function and cause permanent disfigurement. Currently, few objective and validated measures exist to assess IHs. To determine the utility of infrared thermography in assessing and monitoring the growth of IHs. In a prospective cohort study conducted at an outpatient dermatology clinic of a tertiary care hospital between February 2011 and December 2012, a convenience sample of 42 infants aged 0 to 6 months with an IH were enrolled. The mean age of the study group was 3.7 months, with the majority of IHs being mixed type (57%) affecting the head and neck (81%). Of the infants, 36 (86%) were receiving active treatment during the study period, and patients were followed for a minimum of 3 clinical visits, at least 1 month apart. Ability of infrared thermography to assess the proliferation and involution of IHs compared with a visual analog scale. Secondary outcomes were reliability, ease of use, and parental acceptance of the instrument. The mean temperature difference at baseline was 1.9°F (95% CI, 1.2°F to 2.7°F), which peaked at 3 months to 2.5°F (95% CI, 0.8°F to 4.2°F), and decreased progressively to 0.2°F (95% CI, -1.1°F to 1.4°F) at 18.5 months (P < .001). This change in temperature was inversely correlated with mean visual analog scale (r = -0.25). Mean temperature differences recorded at baseline and 30 minutes later were not significant (least squares mean baseline temperature, 87.9°F [95% CI, 87.4°F to 88.3°F], vs least squares mean temperature after 30 minutes, 88.1°F [95% CI, 87.7°F to 88.6°F] [P = .14]). Multivariate analysis demonstrated facial location (F(1,365) = 47.63, P < .001), IH type (F(2,365) = 3.26, P = .04), age (F(2,365) = 7.03, P = .001), and surface area at baseline (F(2,365) = 8.18, P < .001) as factors significantly affecting temperature difference over time. Only

  10. Diffuse hepatic hemangioma with single cutaneous hemangioma: an alerting occurrence.

    Science.gov (United States)

    Al Tasseh, Faten; El-Khansa, Merna; Abd, Omran; Abdel Khalek, Anoir; El-Rifai, Nahida

    2017-06-01

    Screening of infants with five or more cutaneous infantile hemangiomas with abdominal ultrasound is often recommended. However, diffuse hepatic hemangioma can develop even in patients with single cutaneous hemangioma. This highlights the importance of physical examination and screening ultrasound in these patients.

  11. Diffuse hepatic hemangioma with single cutaneous hemangioma: an alerting occurrence

    OpenAIRE

    Al Tasseh, Faten; El?Khansa, Merna; Abd, Omran; Abdel Khalek, Anoir; El?Rifai, Nahida

    2017-01-01

    Key Clinical Message Screening of infants with five or more cutaneous infantile hemangiomas with abdominal ultrasound is often recommended. However, diffuse hepatic hemangioma can develop even in patients with single cutaneous hemangioma. This highlights the importance of physical examination and screening ultrasound in these patients.

  12. Molecular and immunohistochemical expression of apoptotic proteins Bax, Bcl-2 and Caspase 3 in infantile hemangioma tissues as an effect of propranolol treatment.

    Science.gov (United States)

    Wnęk, Aneta; Andrzejewska, Ewa; Kobos, Józef; Taran, Katarzyna; Przewratil, Przemysław

    2017-05-01

    Infantile hemangiomas (IHs) are the most common benign tumors of childhood. They are characterized by a unique clinical course with two phases, proliferation and involution, which are followed by regression. The therapy of infantile hemangiomas was revolutionized in 2008 by the introduction of propranolol, however, the mechanism of its influence on hemangiomas remains unclear. The study included 71 patients with IHs, 27 of whom were treated with propranolol while the remaining 44 were used as a comparative group. The expression of Bcl-2, Bax and Caspase3 was determined with immunohistochemistry and mRNA of Bax, Bcl-2 and Caspase3 were assessed with the use of RT-PCR. Both methods revealed a statistically significant decrease in Bcl-2 expression and an increase in Bax in IHs tissues after propranolol treatment. The results obtained for Bax and Bcl-2 proteins may indicate a link between the effect of propranolol and apoptosis. Higher Bax and lower Bcl-2 expression in the propranolol treated group indicates a strong pro- apoptotic action countering any anti-apoptotic activity; apoptosis was indicted in IH tissue as a potential result of propranolol treatment, with potential clinical impact in other tumors. Copyright © 2017 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

  13. Elevated Serum Levels of Alpha-fetoprotein in Patients with Infantile Hemangioma Are Not Derived from within the Tumor

    Directory of Open Access Journals (Sweden)

    Tinte eItinteang

    2016-02-01

    Full Text Available Aims: The embryonic-like stem cell origin of infantile hemangioma (IH and the observed elevated serum levels of alpha-fetoprotein (AFP in patients with hepatic IH led us to investigate if this tumor was the source of AFP.Materials and Methods: We measured serial serum levels of AFP in patients with problematic proliferating IH treated with surgical excision or propranolol treatment. We also investigated the expression of AFP in extra-hepatic IH samples using immunohistochemical staining, mass spectrometry, NanoString gene expression analysis and in situ hybridization.Results: Serum levels of AFP normalized following surgical excision or propranolol treatment. Multiple regression analysis for curve fittings revealed a different curve compared to reported normal values in the general populations. AFP was not detected in any of the IH samples examined at either the transcriptional or translational levels.Conclusion: This study demonstrates the association of proliferating IH with elevated serum levels of AFP which normalized following surgical excision or propranolol treatment. We have shown that IH is not the direct source of AFP. An interaction between the primitive mesoderm derived IH, and the endogenous endodermal tissues, such as liver, via an intermediary, may explain the elevated serum levels of AFP in infants with extra-hepatic IH.

  14. Is cardiovascular evaluation necessary prior to and during beta-blocker therapy for infantile hemangiomas?: A cohort study.

    Science.gov (United States)

    Raphael, Martine F; Breugem, Corstiaan C; Vlasveld, Florine A E; de Graaf, Marlies; Slieker, Martijn G; Pasmans, Suzanne G M A; Breur, Johannes M P J

    2015-03-01

    Although consensus guidelines for pretreatment evaluation and monitoring of propranolol therapy in patients with infantile hemangiomas (IH) have been formulated, little is known about the cardiovascular side effects. We sought to analyze cardiovascular evaluations in patients with IH at baseline and during treatment with an oral beta-blocker. Data from 109 patients with IH were retrospectively analyzed. Patient and family history, pretreatment electrocardiogram (ECG), heart rate, and blood pressure were evaluated before initiation of beta-blocker therapy. Blood pressure and standardized questionnaires addressing side effects were evaluated during treatment. Questionnaire analyses (n = 83) identified 3 cases with a family history of cardiovascular disease in first-degree relatives. ECG findings were normal in each case and no serious complication of therapy occurred. ECG abnormalities were found in 6.5% of patients but there were no contraindications to beta-blocker therapy and no major complications. Hypotension in 9 patients did not require therapy adjustment. In all, 88 parents (81%) reported side effects during beta-blocker treatment. The relatively small patient cohort is a limitation. Pretreatment ECG is of limited value for patients with an unremarkable cardiovascular history and a normal heart rate and blood pressure. Hypotension may occur during treatment. Copyright © 2014 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  15. Oral propranolol for infantile hemangiomas: a prospective study on the role of 48-hour Holter monitoring in additional safety assessment.

    Science.gov (United States)

    Petrovic, Jelena; Trifunovic, Branislav; Vukomanovic, Goran; Topalovic, Mirko; Trajkovic, Goran; Parezanović, Vojislav

    2017-09-01

    Oral propranolol has been recently approved for infantile hemangiomas (IHs), but potential side effects stay a challenge. We sought to make an additional assessment on oral propranolol safety for this indication. Prospective study included 108 infants consecutively treated for IHs at the University Children's Hospital Tirsova, Belgrade from January 2010 to December 2013. Propranolol was administered orally at a daily dose of 0.5 mg/kg and doubled every 48 hours in the absence of side effects until reaching the maximum dose of 2 mg/kg daily. Systolic and diastolic blood pressure and heart rate were measured every 48 hours with clinical observation. Heart rate was monitored by standard electrocardiogram (ECG) and 48-hour Holter ECG. Statistically significant, but asymptomatic decreases in systolic blood pressure and heart rate recorded by Holter ECG were observed during the first doubling of dose and then remained stable. Arrhythmias were not detected. Despite mild sleep disturbance observed in 31% of infants in the hospital milieu, Holter monitoring indicated circadian rhythm maintenance. Oral propranolol for IHs does not remarkably affect heart rhythm including circadian variations throughout hospital initiation. Therefore, there is no necessity for Holter monitoring in additional safety assessment.

  16. Low-dose propranolol for infantile hemangioma of the head and neck: Analysis of 23 consecutive patients.

    Science.gov (United States)

    Ren, Wenhao; Li, Shaoming; Gao, Ling; Huang, Shuo; Zhang, Linmei; Qiang, Cui; Liu, Chunxi; Zhi, Keqian

    2017-02-01

    More and more infantile hemangiomas (IH) are being treated with propranolol, but the effectiveness, dosage, and treatment course are still in dispute. The aim of this observational study was to describe the therapeutic response, tolerance, and safety of low-dose propranolol in 23 children with IH of the head and neck. Data were collected from the medical charts of patients treated with low-dose propranolol from December 2009 through November 2011. Oral dose was 1-1.5 mg/kg once per day. Blood pressure and heart rate were monitored during the first 24 h of treatment. In the absence of side-effects, treatment was continued at home and the child was re-evaluated every month. All patients had a good response, even if treated with corticosteroid previously. Color and growth changes within 1 week were noted. Treatment continued for a mean total duration of 6 months until the IH had totally disappeared or stabilized. There were no severe adverse reactions. Side-effects were limited and mild, including blood pressure decrease, somnolence, and nausea. No relapse was noted. Low-dose propranolol appears to be effective and safe for IH, especially for those patients previously treated with corticosteroid and who had no response or severe side-effects. © 2016 Japan Pediatric Society.

  17. Effect of topical propranolol gel on plasma renin, angiotensin II and vascular endothelial growth factor in superficial infantile hemangiomas.

    Science.gov (United States)

    Tang, Yu-juan; Zhang, Zai-zhong; Chen, Shao-quan; Chen, Shu-ming; Li, Cheng-jin; Chen, Jian-wei; Yuan, Bo; Xia, Yin; Wang, Lie

    2015-10-01

    The effect of topical propranolol gel on the levels of plasma renin, angiotensin II (ATII) and vascular endothelial growth factor (VEGF) in superficial infantile hemangiomas (IHs) was investigated. Thirty-three consecutive children with superficial IHs were observed pre-treatment, 1 and 3 months after application of topical propranolol gel for the levels of plasma renin, ATII and VEGF in Department of General Surgery of Dongfang Hospital from February 2013 to February 2014. The plasma results of IHs were compared with those of 30 healthy infants of the same age from out-patient department. The clinical efficiency of topical propranolol gel at 1st, and 3rd month after application was 45%, and 82% respectively. The levels of plasma renin, ATII and VEGF in patients pre-treatment were higher than those in healthy infants (565.86 ± 49.66 vs. 18.19 ± 3.56, 3.20 ± 0.39 vs 0.30 ± 0.03, and 362.16 ± 27.29 vs. 85.63 ± 8.14, P renin at 1st and 3rd month after treatment were decreased obviously as compared with those pre-treatment (271.51 ± 18.59 vs. 362.16 ± 27.29, and 405.18 ± 42.52 vs. 565.86 ± 49.66 P 0.05). It was indicated that the increased renin, ATII and VEGF might play a role in the onset or development of IHs. Propranolol gel may suppress the proliferation of IHs by reducing VEGF.

  18. Beta-blockers versus corticosteroids in the treatment of infantile hemangioma: an evidence-based systematic review.

    Science.gov (United States)

    Xu, Shi-Qiong; Jia, Ren-Bing; Zhang, Wei; Zhu, Huang; Ge, Sheng-Fang; Fan, Xian-Qun

    2013-08-01

    The efficacy and safety of beta-blockers versus corticosteroids in the treatment of infantile hemangiomas (IHs) is controversial. This study aimed to summarize evidence described in the literature and to assess the quality of studies involving beta-blockers and corticosteroids for the treatment of cutaneous IHs. Comparative studies were collected from 15 online electronic databases, including OVID Medline, PubMed, ISI Web of Science, CENTRAL, CNKI, ChiCTR, JPCTR, CTRIndia, IranCTR, SLCTR, ISRCTRN, NLCTR, GCTR, ANCTR, ClinicalTrial. gov, and associated references. Studies without a control group were excluded, and the remaining studies were assessed by two reviewers independently using the Downs & Black scale for reported quality. The main areas assessed in the included studies were volume changes, overall improvement in appearance, eye function, and adverse events. Ten comparative studies were included with a total of 419 children. A meta-analysis was not performed due to the considerable heterogeneity across studies. Some evidence showed that beta-blockers are superior to steroids in reducing volume and improving the overall appearance of IHs, such as lightening of the color and flattening of the surface. Conclusions regarding improved eye function and adverse events were divided, and no consensus has been reached on the superiority of one treatment over another. No episodes of severe-onset asthma, hypotension, or bradycardia occurred in the beta-blocker treatment due to the rigorous exclusion of patients with contraindications. Available studies indicate that beta-blockers are an alternative option to corticosteroids for IH treatment with respect to volume shrinkage and improvement in appearance. No evidence has shown a significant difference in improved eye function and adverse events between beta-blockers and corticosteroids in the treatment of IH; indeed, there is a lack of well-designed, high-quality randomized control trials.

  19. Angiographic features of rapidly involuting congenital hemangioma (RICH)

    Energy Technology Data Exchange (ETDEWEB)

    Konez, Orhan; Burrows, Patricia E. [Department of Radiology, Children' s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 (United States); Mulliken, John B. [Division of Plastic Surgery, Children' s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 (United States); Fishman, Steven J. [Department of Pediatric Surgery, Children' s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 (United States); Kozakewich, Harry P.W. [Department of Pathology, Children' s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 (United States)

    2003-01-01

    Rapidly involuting congenital hemangioma (RICH) is a recently recognized entity in which the vascular tumor is fully developed at birth and undergoes rapid involution. Angiographic findings in two infants with congenital hemangioma are reported and compared with a more common postnatal infantile hemangioma and a congenital infantile fibrosarcoma. Congenital hemangiomas differed from infantile hemangiomas angiographically by inhomogeneous parenchymal staining, large and irregular feeding arteries in disorganized patterns, arterial aneurysms, direct arteriovenous shunts, and intravascular thrombi. Both infants had clinical evidence of a high-output cardiac failure and intralesional bleeding. This congenital high-flow vascular tumor is difficult to distinguish angiographically from arteriovenous malformation and congenital infantile fibrosarcoma. (orig.)

  20. Liver Hemangioma

    Science.gov (United States)

    Liver hemangioma Overview A liver hemangioma (he-man-jee-O-muh) is a noncancerous (benign) mass in the liver. A liver hemangioma is made up of a tangle of blood vessels. Other terms for a liver hemangioma are hepatic hemangioma and cavernous hemangioma. Most ...

  1. Downregulation of miR-382 by propranolol inhibits the progression of infantile hemangioma via the PTEN-mediated AKT/mTOR pathway.

    Science.gov (United States)

    Li, Dongfan; Li, Peng; Guo, Zhengtuan; Wang, Huaijie; Pan, Weikang

    2017-03-01

    Approximately 10% of infantile hemangiomas (IHs) are the most common vascular tumors affecting children and are characterized by rapid growth, and can have destructive, disfiguring and even life-threatening consequences. Currently, propranolol is considered to be a safe and effective treatment option for problematic proliferating IHs. Recent studies have also revealed that microRNAs (miRNAs or miRs) play important roles in the regulation of angiogenesis. In this study, XPTS‑1 cells were used as a hemangioma-derived endothelial cell line constructed in our laboratory. Through a series of experiments, we discovered that miR‑382 is a novel miRNA associated with IHs, which was overexpressed in XPTS‑1 cells and was conversely downregulated by treatment with propranolol. In addition, we found that miR‑382 contributes to the progression of IHs. Our results revealed that propranolol inhibited XPTS‑1 cell migration and proliferation, and promoted apoptosis, and these effects were reversed by the restoration of miR‑382 expression by transfection of the cells with an miR‑382 overexpression vector. Further experiments revealed that the above-mentioned effects were associated with the phosphatase and tensin homolog (PTEN)-mediated AKT/mammalian target of rapamycin (mTOR) signaling pathway. The expression of PTEN was upregulated, while that of p-AKT, p-mTOR and p-p70S6K was downregulated by propranolol; these effects were partly reversed by the overexpression of miR‑382. On the whole, our study identified that the downregulation of miR‑382 by propranolol inhibits the progression of IHs via the PTEN-mediated AKT/mTOR pathway.

  2. Propranolol treatment of infantile hemangioma (IH) is not associated with developmental risk or growth impairment at age 4 years.

    Science.gov (United States)

    Moyakine, Andre Vadimovich; Kerstjens, Jorien Maria; Spillekom-van Koulil, Saskia; van der Vleuten, Catharina Joanna Maria

    2016-07-01

    Long-term adverse effects of propranolol treatment for infantile hemangioma (IH) in young children have been suggested. To compare growth and development in children treated with propranolol for IH with nontreated healthy controls. Eighty two (73%) children with IH aged 43 to 51 months treated with propranolol for 6 months or longer, and without other developmental risk factors, were recruited (cases) and matched with 4 twin counterparts and 78 children from a community-based cohort (control subjects). Parents completed the 48-months Ages and Stages Questionnaire (ASQ). Percentages of children with abnormal ASQ results were compared using χ(2) analyses. Mean ASQ scores and growth were compared using Mann-Whitney U tests. Six (7.3%) cases had abnormal ASQ results, compared with 10 (12.2%) controls (P = .292). Mean ASQ total score (25th-75th percentile) was 52.9 (50.8-57.0) for cases and 51.9 (49.0-56.0) for controls (P = .383). Height and weight of cases and controls were comparable. A parent-completed screening instrument was used. The exclusion of children born at gestational age less than 36 weeks and/or children born small for gestational age partly limits generalizability. We found no increased developmental risk or growth impairment at age 4 years in patients with IH treated with propranolol. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  3. Congenital infantile fibrosarcoma of the lip.

    Science.gov (United States)

    Bellfield, Edward J; Beets-Shay, Linda

    2014-01-01

    Infantile congenital fibrosarcomas are rare neoplasms that usually present on the extremities, and although they are locally invasive, they rarely metastasize. They are commonly misdiagnosed as hemangiomas or other vascular tumors, so further evaluation by pathology is required for proper diagnosis. We describe a newborn with a neoplastic growth of the lower lip that was thought to be an infantile hemangioma that did not respond to therapy. When the child was 2 months old, an incisional biopsy demonstrated a fibrosarcoma. This case highlights congenital infantile fibrosarcoma as a mimic of infantile hemangioma. To our knowledge this is first case report of congenital infantile fibrosarcoma involving the lip. © 2013 Wiley Periodicals, Inc.

  4. Congenital hemangioma.

    Science.gov (United States)

    Amouri, Meriem; Mesrati, Hela; Chaaben, Hend; Masmoudi, Abderrahmen; Mseddi, Madiha; Turki, Hamida

    2017-01-01

    Congenital hemangiomas (CHs) are fully developed hemangiomas that are present at birth. There are 2 possible types: rapidly involuting CHs (RICHs) and noninvoluting CHs (NICHs). We conducted a retrospective study (2008-2012) of 6 patients (2 females, 4 males) with CHs (mean age, 16 days). We analyzed the epidemiology, clinical characteristics, and clinical outcome of CHs over this 5-year period.

  5. [Cutaneous hemangioma: clinical aspects].

    Science.gov (United States)

    Casanova, D; Norat, F; Bardot, J; Magalon, G

    2006-01-01

    Infantile cutaneous hemangioma is a benign vascular tumour present at 10% of the infants. It forms part of the group of the vascular tumours in the classification of International Society for Vascular Anomalies (ISSVA). Clinical diagnosis is easy in its triphasic typical form with a phase of sometimes brutal postnatal growth, a phase of stabilization and a phase of slow secondary regression. Classically, it is presented in the form of a mass or stains cutaneous red, of a subcutaneous mass or, generally, of a mixed form associating the two aspects.

  6. Hepatic hemangioma

    Science.gov (United States)

    ... MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools Español You Are Here: Home → Medical Encyclopedia → Hepatic hemangioma URL of this page: //medlineplus.gov/ency/ ...

  7. Clinical spectrum and risk of PHACE syndrome in cutaneous and airway hemangiomas.

    Science.gov (United States)

    Haggstrom, Anita N; Skillman, Sarah; Garzon, Maria C; Drolet, Beth A; Holland, Kristen; Matt, Bruce; McCuaig, Catherine; Metry, Denise W; Morel, Kimberly; Powell, Julie; Frieden, Ilona J

    2011-07-01

    To describe the clinical presentation and risk of PHACE syndrome in infants with large facial hemangiomas and concomitant airway hemangiomas. The study involved a case series of infants with cutaneous hemangiomas and airway hemangiomas extracted from a prospective multicenter cohort study. Data regarding clinical features, diagnosis, treatment, and clinical course were obtained from medical charts and physician intake forms. All patients were evaluated for PHACE syndrome using a standardized protocol. Six academic pediatric dermatology clinics. The study included 17 patients younger than 1 year who were diagnosed as having large (>22 cm(2)) facial hemangiomas and airway hemangiomas. Thirteen patients (76%) had hemangiomas in the bilateral mandibular distribution. Other observed facial patterns included limited involvement of the lip and chin, unilateral reticular frontotemporal and preauricular hemangiomas, and large unilateral hemifacial hemangiomas. Fourteen patients (82%) had symptomatic airway involvement. All symptomatic patients had subglottic airway hemangiomas. The airway hemangioma was circumferential in 10 patients (58%) and more focal in distribution in 7 patients (42%). All patients were treated with oral prednisolone. Eleven patients required additional multimodal therapy. Eight patients (47%) met the criteria for PHACE syndrome. Airway hemangiomas represent a potentially fatal complication of infantile hemangiomas. Our data highlight cutaneous presentations in patients with subglottic hemangiomas and large (>22 cm(2)) cutaneous hemangiomas. PHACE syndrome was detected in 8 such patients (47%) in our series.

  8. Verrucous hemangioma

    Directory of Open Access Journals (Sweden)

    M J Cyriac

    1990-01-01

    Full Text Available A 45 years old male had a warty growth on the thigh diagnosed as verrucous hemangioma histopathologically. Earlier he had received treatment under the clinical diagnoses of verruca vulgaris and tuberculosis verrucosa cutis. The lesion was treated with surgical excision and grafting.

  9. Modern Management of Nasal Hemangiomas.

    Science.gov (United States)

    Keller, Robert G; Stevens, Shawn; Hochman, Marcelo

    2017-07-01

    Current treatment approaches for infantile hemangiomas of the nose include observation, pharmacologic agents, surgery, and/or laser therapy. Because of the known functional, social, and cosmetic effect of nasal deformities, obtaining the best possible result is critical. Optimal timing, type, duration, and extent of therapy remain unclear. Results of a review of 86 patients (64 females and 22 males; mean age, 4.8 months [range, 2 days-23 years]) with infantile hemangiomas of the nose treated from January 1, 1999, to December 31, 2015, and a review of the literature are presented to gain insight into the preferred approach to the treatment of these lesions. Patients underwent single-modality and multimodality treatment with pulsed-dye laser (n = 73), oral corticosteroids (n = 11), intralesional corticosteroids (n = 2), propranolol hydrochloride (n = 30), and surgery (n = 50). The treatment decision algorithms and outcomes based on tumor phase and infantile hemangioma subtype are reviewed in detail. Nine articles met the criteria to be included in the literature review. Literature from the era before the approval of propranolol advocates for early use of oral or intralesional corticosteroids followed by surgery or pulsed-dye laser in cases of unacceptable outcomes. Literature from the era after the approval of propranolol supports early initiation of oral β-blockers until proliferation ceases or until additional intervention is necessary. Despite a lack of higher levels of evidence, there exists a general consensus between the literature and clinical experience advocating for early multimodality treatment to achieve the best result possible by the time the children reach certain sociodevelopmental milestones.

  10. LUMBAR syndrome: A case manifesting as cutaneous infantile hemangiomas of the lower extremity, perineum and gluteal region, and a review of published work.

    Science.gov (United States)

    Yu, Xia; Zhang, Jia; Wu, Zhouwei; Liu, Ming; Chen, Ruhong; Gu, Yan; Li, Ming; Yao, Zhirong

    2017-07-01

    We herein report a rare case of LUMBAR syndrome. A 1-month-old female infant presented with extensive segmental hemangiomas on the left lower extremity, left perineum and gluteal region with ulceration. Bilateral labia minoras were asymmetrical. Both legs were asymmetrical with left leg atrophy, and the intergluteal cleft was deviated. A dark red pustule and a sacrococcygeal dimple could be seen in the lumbosacral region. Lipomyelomeningocele, tethered cord and sacrum dysplasia were noted by magnetic resonance imaging. The patient was found to have an absent left kidney at 32 weeks of pregnancy. Eventually, we draw the diagnosis of LUMBAR syndrome. In addition, we discuss the clinical manifestation, diagnosis, treatment and pathogenesis by a review of published work. © 2017 Japanese Dermatological Association.

  11. Propranolol treatment in life-threatening airway hemangiomas: a case series and review of literature

    NARCIS (Netherlands)

    Broeks, I.J.; Hermans, D.J.J.; Dassel, A.C.; Vleuten, C.J.M. van der; Beynum, I.M. van

    2013-01-01

    OBJECTIVES: Infantile hemangiomas (IHs) in the airway may be potentially life-threatening during the proliferative phase. Available treatments like oral corticosteroids (OCS) and chemotherapeutic agents usually showed variable responses and serious side effects. Propranolol is a new and promising

  12. Glomeruloid hemangioma.

    Science.gov (United States)

    Yuri, Takashi; Yamazaki, Fumikazu; Takasu, Kosho; Shikata, Nobuaki; Tsubura, Airo

    2008-06-01

    A 64-year-old Japanese woman suffering from idiopathic thrombocytopenic purpura was treated with prednisolone. During the course of steroid withdrawal she developed parotid gland enlargement and cervical lymph node swelling with multiple dome-shaped red papules on her trunk and upper limbs. On admission the patient was found to have numbness of her lower limbs (polyneuropathy), lymph node swelling (organomegaly), high glucose level (endocrinopathy), Bence-Jones protein-kappa in the urine (M protein) and skin with hyperpigmentation, hypertrichosis and multiple glomeruloid hemangiomas (skin abnormalities), indicating polyneuropathy-organomegaly-endocrinopathy-M-protein-skin abnormality (POEMS) syndrome. The patient was also found to have peripheral edema, ascites, and pleural effusion. The glomeruloid hemangiomas had intravascular capillary growth, which was composed of conglomerates of capillaries resulting in structures resembling renal glomeruli. Cells within the capillary loops were lined by endothelial cells with scant cytoplasm (CD31(+)/CD34(+)/CD68(-)/CD105(+)/UEA-1(+)) while the outer surfaces of the loops were covered by either swollen endothelial cells containing PAS- and immunoglobulin-positive eosinophilic hyaline globules (CD31(+)/CD34(-)/CD68(-/+)/CD105(-)/UEA-1(-)) or cells without globules. These two phenotypically different endothelial cells were separated by alpha-smooth muscle actin-positive pericytes. Pericytes and endothelial cells covering the outer surface of the loops were bordered by basement membrane. Biopsy of parotid gland and lymph node indicated Sjögren's syndrome and Castleman's disease of a hyaline-vascular type, respectively. Resumed prednisolone therapy has been successful, and the patient was left with minimal residual symptoms. Glomeruloid hemangioma is a specific marker of POEMS syndrome and is related to Castleman's disease. Idiopathic thrombocytopenic purpura and Sjögren's syndrome may also be related.

  13. Hemangiomas Infantis

    OpenAIRE

    Campos, S; Paiva Lopes, MJ

    2013-01-01

    De acordo com a International Society for the Study of Vascular Anomalies (ISSVA), as anomalias vasculares são divididas em dois grupos: tumores e malformações vasculares. Os tumores vasculares resultam da proliferação benigna do endotélio vascular. As malformações vasculares, por sua vez, resultam de erros na morfogénese vascular com a formação de vasos displásicos. Os hemangiomas infantis (HI) são os tumores vasculares benignos mais comuns da infância, estando presentes em até 5% da...

  14. Inhibition of hemangioma growth using polymer-lipid hybrid nanoparticles for delivery of rapamycin.

    Science.gov (United States)

    Li, Haitao; Teng, Yunfei; Sun, Jin; Liu, Jianyong

    2017-11-01

    Although infantile hemangiomas is benign, its rapid growth may induce serious complications. However, only one drug Hemangeol™ has been approved by US Food and Drug Administration (FDA) to treat infantile hemangiomas. Thus it is necessary to develop novel alternative drugs to treat infantile hemangiomas. Rapamycin is a well-know potent antiangiogenic agent, whereas the daily oral administration of rapamycin exerts undesired metabolic effects due to its inhibition of mechanistic target of rapamycin (mTOR) which is critical in cell metabolism. We hereby developed rapamycin-loaded polymer-lipid hybrid nanoparticles (Rapamycin-PLNPs) as a local controlled release system to realize local and sustained release of rapamycin, aiming to reduce the side effects and frequency of administration of rapamycin. Rapamycin-PLNPs are of a small size (129.1nm), desired drug encapsulation efficiency (63.7%), and sustained drug release for 5 days. Rapamycin-PLNPs were shown to be able to effectively bind to hemangioma endothelia cells (HemECs), induce significant proliferation inhibition and reduce expression of angiogenesis factors in HemECs. The therapeutic effect of Rapamycin-PLNPs against infantile hemangioma in vivo was superior to rapamycin, as reflected by reduced hemangioma volume, weight and microvessel density. Taken together, Rapamycin-PLNPs represent a very promising local approach in the treatment of infantile hemangiomas. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  15. Tratamiento exitoso de un hemangioma de parótida con propranolol Successful treatment of parotid hemangioma by using propranolol

    OpenAIRE

    Edelisa Moredo Romo; Fernanda Pastrana Fundora

    2012-01-01

    Los hemangiomas infantiles son los tumores vasculares benignos más frecuentes en la infancia, que ocurren mayormente en los pacientes pretérmino, en un 80 % afectan cabeza y cuello, y en algunos pacientes provocan serias complicaciones para la vida. El hemangioma de parótida es una forma clínica de presentación en la que suele verse un período proliferativo prolongado con lenta involución. Se presenta el caso clínico de un paciente con diagnóstico de hemangioma de parótida con componente supe...

  16. Oral Propranolol for Circumscribed Choroidal Hemangioma

    Directory of Open Access Journals (Sweden)

    Empar Sanz-Marco

    2011-02-01

    Full Text Available Introduction: Several therapeutic approaches have been developed to treat choroidal hemangioma. However, all these therapies are associated with a potential risk of damaging the overlying retina. Case Report: We report a case of circumscribed choroidal hemangioma (CCH in a 59-year-old man refractory to laser treatment. Visual acuity was 20/200 and a serous macular detachment was present. The CCH was treated with oral propanolol, whereupon visual acuity improved to 20/20 and the macular detachment resolved without systemic or local adverse effects. Discussion: Propanolol is a β-blocker commonly used in cardiology that may induce endothelium vasoconstriction and inhibit endothelial proliferation. It has been shown to be effective in infantile facial hemangiomas, and proved safe and effective for the CCH in our patient. Further studies are needed to confirm our observation.

  17. Oral Propranolol for Circumscribed Choroidal Hemangioma

    Science.gov (United States)

    Sanz-Marco, Empar; Gallego, Roberto; Diaz-Llopis, Manuel

    2011-01-01

    Introduction Several therapeutic approaches have been developed to treat choroidal hemangioma. However, all these therapies are associated with a potential risk of damaging the overlying retina. Case Report We report a case of circumscribed choroidal hemangioma (CCH) in a 59-year-old man refractory to laser treatment. Visual acuity was 20/200 and a serous macular detachment was present. The CCH was treated with oral propanolol, whereupon visual acuity improved to 20/20 and the macular detachment resolved without systemic or local adverse effects. Discussion Propanolol is a β-blocker commonly used in cardiology that may induce endothelium vasoconstriction and inhibit endothelial proliferation. It has been shown to be effective in infantile facial hemangiomas, and proved safe and effective for the CCH in our patient. Further studies are needed to confirm our observation. PMID:21475606

  18. Hemangioma coroideo

    Directory of Open Access Journals (Sweden)

    Kenia Galindo Reymond

    Full Text Available El hemangioma coroideo circunscrito es un tumor vascular hamartomatoso benigno de baja incidencia. Se presenta este caso debido a su evolución lenta y la pobre respuesta a tratamiento con terapia fotodinámica. El paciente, de sexo masculino, 49 años de edad, con disminución de la visión del ojo derecho de ocho meses de evolución y sin otra sintomatología asociada. Las exploraciones complementarias realizadas (retinografia, OCT, Ecografía y Angiografía flurosceínica evidencian un tumor yuxtapapilar nasal que es diagnosticado como hemangioma circunscrito de coroides. Se decide tratarlo con terapia fotodinámica. En este caso, aunque el resultado en la ganancia visual no es el esperado, en los exámenes complementarios realizados se observa una discreta mejoría. La lenta evolución de este paciente responde, a criterio de los autores, a varios factores como la edad, el deterioro de la visión en el momento del diagnóstico, el número de aplicaciones de tratamiento con la TFD realizadas, el tiempo de evolución del tumor y el tamaño de la lesión.

  19. Different Clinical Features of Acral Abortive Hemangiomas

    Directory of Open Access Journals (Sweden)

    N. Vega Mata

    2017-01-01

    Full Text Available Some infantile hemangiomas called in literature “minimal or arrested growth hemangiomas” or “abortive hemangiomas” are present at birth and have a proliferative component equaling less than 25% of its total surface area. Often, they are mistaken for vascular malformation. We present five patients (three girls and two boys with abortive hemangiomas diagnosed between January 2010 and December 2015 localized in acral part of the extremities. They were congenital lesions resembling precursor of hemangiomas but did not show proliferation phase. Immunohistochemical Glut-1 was performed in all of them as a way to confirm the abortive hemangioma diagnosis. The most common appearance was a reticulated erythematous patch with multiple fine telangiectasias on the surface. We remark that one of them presented a segmental patch with two different morphologies and evolutions. The proximal part showed pebbled patches of bright-red hemangioma and presented proliferation and the distal part with a reticulated network-like telangiectasia morphology remained unchanged. We detected lower half of the body preference and dorsal region involvement preference without ventral involvement. The ulceration occurred in three patients with two different degrees of severity.

  20. Tratamiento exitoso de un hemangioma de parótida con propranolol Successful treatment of parotid hemangioma by using propranolol

    Directory of Open Access Journals (Sweden)

    Edelisa Moredo Romo

    2012-06-01

    Full Text Available Los hemangiomas infantiles son los tumores vasculares benignos más frecuentes en la infancia, que ocurren mayormente en los pacientes pretérmino, en un 80 % afectan cabeza y cuello, y en algunos pacientes provocan serias complicaciones para la vida. El hemangioma de parótida es una forma clínica de presentación en la que suele verse un período proliferativo prolongado con lenta involución. Se presenta el caso clínico de un paciente con diagnóstico de hemangioma de parótida con componente superficial y profundo, tratado con propranolol, con excelente respuesta al tratamiento, involución completa clínica e imaginológica del tumor en 10 semanas.Infantile hemangiomas are the most common benign vascular tumors in childhood that mostly emerge in preterm patients, affect head and neck in 80% of cases and cause serious life-threatening complications for some patients. The parotid hemangioma is a clinical form of presentation that may be seen in a prolonged proliferative period with slow regression. This is the clinical case of a patient diagnosed with parotid hemangioma of superficial and deep component. He was treated with propranolol, showed excellent response to treatment, and complete clinical and imaging regression of tumor in a 10-week period.

  1. Hemangioma colorretal Colon rectal hemangioma

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    João Batista Pinheiro Barreto

    2007-06-01

    Full Text Available O hemangioma colorretal (HCR é uma lesão vascular benigna rara, com manifestação clínica geralmente entre 5 e 25 anos de idade. Faz parte do diagnóstico diferencial das causas de hemorragia digestiva baixa, sendo confundido, na maioria das vezes, com entidades mais comuns, como hemorróidas e doenças inflamatórias intestinais. O retardo do diagnóstico ocorre freqüentemente devido ao desconhecimento da doença, com taxas de mortalidade alcançando 40 a 50% na presença de sangramento importante. O caso relatado é de uma paciente de 17 anos de idade, admitida no Serviço de Colo-proctologia do Hospital Universitário - HUUFMA, em setembro de 2005, com anemia e sangramento retal, desde a infância, de forma intermitente e não dolorosa. Apresentado sua história clínica e propedêutica diagnóstica, realizada por meio de exames laboratoriais, endoscopia digestiva alta, colonoscopia e arteriografia de mesentéricas e ilíacas internas. O tratamento cirúrgico realizado foi retossigmoidectomia convencional com anastomose colorretal baixa, com boa evolução pós-operatória, tendo o exame histopatológico da peça cirúrgica ressecada, confirmado o diagnostico.The colon and rectum hemangioma is a rare benign vascular lesion, with clinical features usually between 5 and 25 years of age. It is included in the differential diagnose of the lower digestive bleeding causes, and has been frequently misdiagnosed with other more common entities, like hemorrhoids and bowel inflammatory disease. The late diagnose occurs usually because of the rarity of the disease, with mortality rates reaching 40 to 50% in presence of severe bleeding. We report a case of a 17 years old girl who was admitted at the Coloproctology Service of the Academic Hospital - HUUFMA, in September 2005, with anemia and intermittent rectal bleeding since childhood. Laboratorial findings included laboratorial exams, GI endoscopy, colonoscopy and arteriography of mesenteric and

  2. Intralesional bleomycin for the treatment of periocular capillary hemangiomas

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    Derrick P Smit

    2012-01-01

    Full Text Available Periocular infantile capillary hemangiomas do not always respond well to conventional treatment modalities such as systemic or intralesional corticosteroids, radiotherapy or debulking surgery. The authors describe the use of intralesional bleomycin injections (IBIs to treat potentially amblyogenic lesions in two cases where other modalities have failed. In both cases monthly IBIs successfully cleared the visual axis of the affected eye before the age of 1 year thus preventing permanent sensory deprivation amblyopia. A total of five and nine injections, respectively, were used and no significant side effects were noted. IBI appears to be a useful alternative in the treatment of periocular capillary hemangiomas refractory to more conventional modalities.

  3. Multiple congenital cranial hemangiomas

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    Koulouris, George [Alfred Hospital, Department of Radiology, Prahran, Victoria (Australia); Rao, Padma [Royal Children' s Hospital, Department of Radiology, Parkville, Victoria (Australia)

    2005-08-01

    Though cranial hemangiomas are second only to vertebral hemangiomas in frequency, such lesions are rarely congenital and multiple. It is probable that the true incidence of congenital calvarial hemangiomas is higher than that reported in the literature, as they are unlikely to undergo imaging, most being asymptomatic and without a significant soft tissue component. We present a case of multiple congenital calvarial and skull base cavernous-type hemangiomas, diagnosed in a 4-day-old female, involving the right zygoma, maxilla, frontal and petrous temporal bones and contralateral squamous temporal bone. Surgical biopsy confirmed the radiological diagnosis as well as the concomitant multiple subcutaneous capillary-type hemangiomas which were identified clinically. No specific clinical syndrome or chromosomal abnormality was identified and the underlying cerebral parenchyma was normal with no intra-axial involvement. With conservative treatment, two lesions completely resolved and a further two lesions subsequently decreased in both size and degree of enhancement. To the best of our knowledge, this is the first case of multiple congenital hemangiomas involving the calvarium and skull base. Despite this, the radiological features, combined with the clinical findings of multiple capillary hemangiomas, were characteristic enough to permit an accurate preoperative diagnosis. Osseous hemangiomas should feature prominently in any differential diagnosis of multiple hypervascular lesions, as they are common, more so when limited to an anatomical region, irrespective of site or age. (orig.)

  4. Hepatic hemangioma: atypical appearance

    Energy Technology Data Exchange (ETDEWEB)

    Mikulis, D.J.; Costello, P.; Clouse, M.E.

    1985-07-01

    Recent reports indicate that computed tomography (CT) after bolus injection of contrast material is diagnostically specific for hemangioma, replacing the need for angiography in a high percentage of patients. The authors report a unique hepatic hemangioma that showed early diffuse intense opacification by angiography and contrast-enhanced CT.

  5. CD105 expression in oral capillary hemangiomas and cavernous hemangiomas.

    Science.gov (United States)

    Matsumoto, Naoyuki; Tsuchiya, Motomi; Nomoto, Shouta; Matsue, Yasuyoshi; Nishikawa, Yohichi; Takamura, Tsuyoshi; Oki, Hidero; Komiyama, Kazuo

    2015-03-01

    Capillary hemangioma (capillary lobular hemangioma) and cavernous hemangioma (venous malformation) are relatively common oral tumors/malformations and are characterized by increased numbers of normal and abnormal blood vessels. However, the causes of these lesions are not well understood. CD105 (endoglin) is predominantly expressed in proliferating blood endothelial cells (ECs). We analyzed expressions of CD105, CD34, von Willebrand factor, Ki-67, cyclooxygenase-2 (COX-2), and vascular endothelial growth factor (VEGF)-A in 31 capillary hemangiomas and 34 cavernous hemangiomas. Staining scores were calculated as the product of the proportion score and intensity score. Morphologically normal oral mucosa specimens (n = 10) were simultaneously evaluated as normal controls. As compared with cavernous hemangiomas and normal controls, capillary hemangiomas had higher staining scores for CD105, VEGF-A, and COX-2. The Ki-67 labeling index was significantly higher in capillary hemangiomas than in cavernous hemangiomas and normal controls (P characteristics of capillary and cavernous hemangiomas are quite different. The ECs of capillary hemangiomas actively proliferated and were generally regulated by VEGF-A. In contrast, the ECs of cavernous hemangiomas lacked proliferative activity. These results suggest that angiogenesis and vasodilatation of pre-existing blood vessels are important in the development of capillary hemangioma and cavernous hemangioma, respectively.

  6. Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism.

    Science.gov (United States)

    Bessho, Kazuhiko; Etani, Yuri; Ichimori, Hiroaki; Miyoshi, Yoko; Namba, Noriyuki; Yoneda, Akihiro; Ooue, Takaharu; Chihara, Tsuyoshi; Morii, Eiichi; Aoki, Tomoyuki; Murakami, Masami; Mushiake, Sotaro; Ozono, Keiichi

    2010-02-01

    Infantile hepatic hemangioma with consumptive hypothyroidism is a rare condition. A 4-month-old girl presented with diffuse hepatic hemangiomas during treatment of congenital hypothyroidism. Serum reverse triiodothyronine was elevated, and her hypothyroidism improved concomitant with involution of the hemangioma following prednisolone and interferon-alpha administration. At 20 months of age, 7 months after discontinuing prednisolone and interferon-alpha, a focal hemangioma regrew from one of the previous lesions and was surgically resected. The expression and activity of type 3 iodothyronine deiodinase (D3) were elevated in the resected tumor tissue compared with placenta. Here, we describe a patient with consumptive hypothyroidism and diffuse infantile hepatic hemangiomas, one of which regrew after involution following pharmacotherapy. The etiology of elevated D3 activity is also discussed. It is important to identify infantile hepatic hemangioma in patients with hypothyroidism refractory to hormone replacement therapy, who have low free triiodothyronine despite high thyrotropin and normal free thyroxine levels, and long-term follow-up will be needed for these patients.

  7. Tratamiento exitoso de un hemangioma de parótida con propranolol

    OpenAIRE

    Edelisa Moredo Romo; Fernanda Pastrana Fundora

    2012-01-01

    Los hemangiomas infantiles son los tumores vasculares benignos más frecuentes en la infancia, que ocurren mayormente en los pacientes pretérmino, en un 80 % afectan cabeza y cuello, y en algunos pacientes provocan serias complicaciones para la vida. El hemangioma de parótida es una forma clínica de presentación en la que suele verse un período proliferativo prolongado con lenta involución. Se presenta el caso clínico de un paciente con diagnóstico de hemangioma de parótida con componente supe...

  8. Guide to Understanding Hemangiomas

    Science.gov (United States)

    ... effects of prolonged steroid therapy include increased irritability (personality changes), gastrointestinal upset, increased or decreased appetite, a ... to vital structures such as the eye, causing blindness. Topical steroid creams applied directly to hemangiomas have ...

  9. Radiotherapy of hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Gauwerky, F.

    1982-10-11

    The findings about the regular, spontaneous and complete regression of cavernous skin hemangiomas occurring in infants and those findings about the damaging effects due to ionising radiation - here particularly local growth disturbances - led to the development of very cautious diagnostic methods and to a considerate individual dosage and radiotherapy, which always takes into consideration the spontaneous regression tendency of the hemangiomas. However, a function-impairing localisation at the orifices, fulminant macrosomia, tendency to hemorrhages and poly-infection with superficial ulceration and even thrombopenic syndromes of the Kasabach-Merritt type may become necessary, urgent and also vital indications for a particular radiotherapy. For the sake of the patients, irradiation methods, which do not provoke any risk of radiation hazards, have to be preserved and applied in practice. Certainly further research and the nosologic nature of hemangiomas is required. A general non-treatment of hemangiomas is refused.

  10. Hepatic hemangioma -review-.

    Science.gov (United States)

    Bajenaru, N; Balaban, V; Săvulescu, F; Campeanu, I; Patrascu, T

    2015-01-01

    Hepatic hemangiomas are benign tumors of the liver consisting of clusters of blood-filled cavities, lined by endothelial cells, fed by the hepatic artery. The vast majority of HH are asymptomatic, most often being discovered incidentally during imaging investigations for various unrelated pathologies. Typical hemangiomas, the so-called capillary hemangiomas, range from a few mm to 3 cm, do not increase in size over time and therefore are unlikely to generate future symptomatology. Small (mm-3 cm) and medium (3 cm-10 cm) hemangiomas are well-defined lesions, requiring no active treatment beside regular follow-ups. However, the so-called giant liver hemangiomas, of up to 10 cm (most commonly) and even 20+ cm in size (according to occasional reports) can, and usually will develop symptoms and complications that require prompt surgical intervention or other kind of therapy. HH belong to the class of hepatic "incidentalomas", so-called because they are diagnosed incidentally, on imaging studies performed as routine examinations or for other reasons than the evaluation of a possible liver mass. Less than half of HH present with overt clinical symptoms, consisting, most often, of upper abdominal pain (this is usually the case for large lesions, which cause the distension of Glisson's capsule). Hepatic hemangiomas require a careful diagnosis to differentiate from other focal hepatic lesions, co-occurring diagnoses are also possible.

  11. Evaluation of intralesional propranolol for periocular capillary hemangioma

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    Awadein A

    2011-08-01

    Full Text Available Ahmed Awadein, Mohamed A FakhryCairo University Faculty of Medicine, Cairo, EgyptBackground: The purpose of this study was to evaluate the use of intralesional propranolol injection in the management of periocular capillary hemangioma.Methods: A prospective study was performed in 22 consecutive patients with periocular hemangioma. Twelve patients underwent intralesional propranolol injection and ten patients underwent intralesional triamcinolone injection. The size of the lesion was measured serially every week during the first month, every 2 weeks for the second month, and then monthly for another 2 months. The refractive error and degree of ptosis if present were measured before injection and at the end of the study.Results: There was reduction in the size of hemangioma, astigmatic error, and degree of ptosis in both groups. The difference in outcome between both groups was not statistically significant. Rebound growth occurred in 25% of the propranolol group and 30% of the steroid group but responded to reinjection. No adverse effects were reported during or after intralesional propranolol injection.Conclusion: Intralesional propranolol injection is an alternative and effective method for treatment of infantile periocular hemangioma.Keywords: propranolol, intralesional, periocular capillary hemangioma

  12. Propranolol Promotes Accelerated and Dysregulated Adipogenesis in Hemangioma Stem Cells

    Science.gov (United States)

    England, Ryan W.; Hardy, Krista L.; Kitajewski, Alex M.; Wong, Alvin; Kitajewski, Jan K.; Shawber, Carrie J.; Wu, June K.

    2014-01-01

    Background Infantile hemangiomas are the most common tumor of infancy, yet there are no FDA-approved therapeutics to date. Recently, the non-selective beta-adrenergic-blocker propranolol has been shown to be a safe and effective means of treating infantile hemangiomas, though its mechanism has yet to be elucidated. We have previously demonstrated that propranolol induces early and incomplete adipogenesis in stem cells derived from hemangiomas. We hypothesize that propranolol promotes dysregulated adipogenesis via the improper regulation of adipogenic genes. Methods Hemangioma stem cells isolated from resected infantile hemangioma specimens were treated with adipogenic medium for 1 or 4 days in either propranolol or vehicle. Cell death was measured by the incorporation of annexin V and propidium iodide by flow cytometry. Adipogenesis was assessed by visualizing lipid droplet formation by Oil Red O staining. Pro-adipogenic genes C/EBPβ, C/EBPβ, C/EBPδ, PPARδ, PPARγ, RXRα, and RXRγ were analyzed by quantitative reverse transcription and polymerase chain reaction. Results Hemangioma stem cells treated with propranolol increased lipid droplet formation compared to vehicle-treated cells indicating increased adipogenesis. Cell death as measured by FACS analysis indicated that the propranolol-treated cells died due to necrosis and not apoptosis. During adipogenesis, transcript levels of PPARδ, PPARγ, C/EBPβ, and C/EBPδ were significantly increased (p propranolol-treated cells relative to control cells. In contrast, RXRα and RXRγ levels were significantly decreased (p propranolol when compared to vehicle-treated cells (p propranolol accelerated dysregulated adipogenic differentiation characterized by improper adipogenic gene expression. Consistent with accelerated adipogenesis, propranolol significantly increased the expression of the pro-adipogenic genes, PPARγ , C/EBPβ and C/EBPγ compared to control. However, propranolol treatment also led to improper

  13. Circumscribed choroidal hemangioma

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    Saeed Karimi

    2015-01-01

    Full Text Available Circumscribed choroidal hemangiomas are benign vascular hamartomas without systemic associations. Generally, they are orange-red elevated masses, which are found posterior to the equator. Lesions are usually solitary and unilateral. Overlying subretinal fluid, serous retinal detachment and cystoid macular edema are common findings. Intravenous fluorescein angiography, indocyanine green angiography, ultrasonography, optical coherence tomography and enhanced depth imaging are helpful ancillary tests for diagnosis of circumscribed choroidal hemangiomas. Asymptomatic circumscribed choroidal hemangiomas do not require treatment. For symptomatic lesions with exudative retinal detachment or cystoid macular edema, photodynamic therapy has emerged as the treatment of choice with high rates of tumor regression, subretinal fluid resorption and minimal complications. Lens-sparing external beam radiotherapy, plaque brachytherapy, proton beam therapy, stereotactic radiosurgery, transpupillary thermotherapy, laser photocoagulation and anti-VEGF injections are other treatment modalities.

  14. Sclerotherapy for oral hemangioma

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    Navadeepak Korvipati

    2016-01-01

    Full Text Available Hemangiomas are well-known benign neoplasms of the body most commonly occurring in the head and neck region and less commonly in the oral cavity. The predominant site of occurrence, in the oral cavity, is lips followed by gingiva, tongue and palate. Treatment is primarily dependent on correct diagnosis of the lesion and its anatomic location. Here, we report a case of hemangioma on posterior third of the tongue in 34-year-old male patient, who was treated by sclerotherapy with sodium tetradecylsulphate (setrol sclerosing agent.

  15. An update of 77 cases diagnosed as oral hemangiomas based on GLUT-1 positivity.

    Science.gov (United States)

    da Silva Filho, Tiago João; de Oliveira, Denise Hélen Imaculada Pereira; Brasil, Veruska Lima Moura; Nonaka, Cassiano Francisco Weege; da Silveira, Éricka Janine Dantas; Queiroz, Lélia Maria Guedes

    2017-08-01

    To evaluate cases diagnosed as "oral hemangiomas" based on the immunohistochemical expression of human glucose transporter protein (GLUT-1) and on histopathological features, and to investigate whether the classification proposed by the ISSVA was used correctly to classify these lesions. All cases stored in the archives of an Oral Pathology Service and diagnosed as "oral hemangiomas" were reviewed. Seventy-seven cases were analyzed regarding the expression of GLUT-1. GLUT-1(+) specimens were classified as true infantile hemangioma (IH) and GLUT-1(-) specimens were reclassified based on their histopathological features. The nomenclature of these lesions was evaluated and some cases were reclassified. Only 26 (33.8%) of the specimens were indeed IHs. Among the GLUT-1(-) specimens, 20 (26.0%) were reclassified as pyogenic granulomas (PGs) and 31 (40.2%) as vascular malformations. Considering the previously applied nomenclature, only 47.5% of the cases initially diagnosed as "hemangiomas" were IHs. In the group of "capillary hemangiomas", most cases (56.2%) were PGs. Among the three "cellular hemangiomas", two were PGs and one was IH. Most (88.8%) "cavernous hemangiomas" were vascular malformations. Careful and parameterized review of cases of vascular anomalies is necessary using auxiliary tools such as GLUT-1, since the exclusive use of histopathological findings might be insufficient to differentiate some anomalies. Accurate clinical examination and the use of biomarkers such as GLUT-1 are essential for the diagnosis. Copyright © 2017. Published by Elsevier Inc.

  16. Linfoma orbitario: reporte de un caso y revisión de la literatura

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    Javier Andrés Galnares Olalde

    2014-07-01

    Full Text Available El linfoma orbitario es un tipo de tumor muy infrecuente que afecta a la órbita y a sus anexos. En raras ocasiones es bilateral. Es de vital importancia hacer un diagnóstico temprano para darle un tratamiento oportuno y así prevenir complicaciones. Nosotros reportamos un caso de un paciente del sexo femenino de 66 años que se presenta al servicio de urgencias de oftalmología por una celulitis periorbitaria. Al no remitir el cuadro, se le hospitalizó para realizar estudios complementarios que concluyeron que se trataba de un linfoma no Hodgkin de tipo B de la zona marginal (MALT. Los aspectos referentes a este tipo de linfoma como su epidemiología, etiología, etapas, diagnóstico y tratamiento se discuten en este reporte de caso.

  17. Parapharyngeal hemangioma with phleboliths

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    S Bhargava

    2011-01-01

    We describe a relatively rare case of hemangioma with numerous phleboliths involving multiple intraoral structures and orofacial spaces in a 30-year-old male patient along with a comprehensive review of literature on the condition and its most popular treatment modalities.

  18. Lipiodol Accumulation in Hepatic Hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Chun, Ki Sung; Park, Jeong Mi; Ha, Hyun Kwon; Shinn, Kyung Sub; Bahk, Yong Whee; Shim, Kyu Sik [Catholic University College of Medicine, Seoul (Korea, Republic of)

    1989-04-15

    In order to establish different features of hemangioma, lipiodol was superselectively infused in three cases of hepatic hemangioma through the proper or a distal branch hepatic artery following hepatic angiogram. Thereafter a plain X-ray of the abdomen and CT were obtained. The present study revealed accumulation of lipiodol within abnormal vascular space of hemangioma to be multiple, stippled, dense and discrete. Follow-up plain abdomen and CT (6 months, 8 months, and 9 months, respectively) demonstrated very slow clearing of lipiodol accumulation without change in size. These findings are considered to be pathognomonic of hemangioma.

  19. Cardiac Cavernous Hemangioma Coexisting With Pulmonary Cavernous Hemangiomas and Giant Hepatic Hemangioma.

    Science.gov (United States)

    Wang, Chunping; Chen, Hao; Sun, Lin; Mei, Yunqing

    2017-02-01

    We describe a case of cardiac cavernous hemangioma with coexisting pulmonary cavernous hemangiomas and hepatic hemangioma. A 35-year-old woman who had previously received a living donor liver transplant to cure giant hepatic hemangioma was seen because of chest pain. A cardiac neoplasm and multiple pulmonary nodules were detected. The tumor was surgically removed, and biopsy specimens were taken from the lung nodules. Histopathologic examination confirmed that both lesions were cavernous hemangiomas. The patient was discharged without adverse events postoperatively. Cardiac hemangioma is an extremely rare entity; the present case is unique for its multiorgan involvement. Suspicion of this entity should be aroused if the imaging manifestation suggests a vascular nature. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  20. [Place of the precocious surgical treatment in facial hemangioma].

    Science.gov (United States)

    Adouani, Ali; Bouguila, Jed; Abdelali, Mouhamed Ali; Ben Aicha, Mahdi; Landolsi, Amani; Hellali, Mouna; Zitouni, Karima; Mahri, Imen; Zairi, Issam

    2008-10-01

    Infantile cutaneous hemangioma is a benign vascular tumour present at 10% of the infants. It forms part of the group of the vascular tumours in the classification of international society for vascular anomalies (ISSVA). Usual surgical attitude is abstention and surgery is proposed only in order to treat sequelae. But some particular situations require early surgery to avoid functional impairment, deformation or growth delay due to the lesion's development. Using our observations, we recall the epidemiology, the physiopathology, the clinical aspects, the particularities of the facial localizations and their treatments. In these localizations the time intervenes like a fourth dimension that is going to modify, to improve or to aggravate the prognosis. Treatment requires a strategy and precocious surgery. We insist on the fact that the dogma of the therapeutic abstention remained true for a majority of children with small size hemangioma and that a precocious surgery must be proposed for some localizations in the face.

  1. Propranolol for extensive hemangiomas of infancy: two case reports Hemangiomas extensos da infância tratados com propranolol: relato de dois caso

    Directory of Open Access Journals (Sweden)

    Luíza Helena dos Santos Cavaleiro

    2011-06-01

    Full Text Available Hemangiomas are the most common benign tumors of childhood. They show rapid growth, followed by a regression phase that culminates in the partial or total disappearance of the lesion. Therapeutic options should be evaluated for extensive cases. Systemic glucocorticoids are the therapy of choice; however, there are reports that propranolol offers better and faster results. We report two cases of large volume infantile hemangioma associated with functional limitation and aesthetic disfigurement, treated successfully with propranolol, a drug that comes as a therapeutic option providing satisfactory and maintained results, with few side effects.Hemangiomas são os tumores benignos mais frequentes da infância, apresentando como história natural crescimento rápido, seguido de uma fase de regressão que culmina com o desaparecimento parcial ou total da lesão. Opções terapêuticas devem ser avaliadas para casos extensos. Os glicocorticoides sistêmicos são a terapia de escolha; contudo, há relatos de que o propranolol oferece resultados melhores e mais rápidos. Este trabalho descreve dois casos de hemangioma infantil de grande volume associados à limitação funcional e desfiguração estética com significativa resposta ao propranolol, droga esta que surge como uma proposta terapêutica oferecendo resultados satisfatórios e mantidos, com poucos efeitos colaterais.

  2. Brimonidine Toxicity Secondary to Topical Use for an Ulcerated Hemangioma.

    Science.gov (United States)

    Gill, Kamalvir; Bayart, Cheryl; Desai, Ritu; Golden, Alex; Raimer, Patricia; Tamburro, Joan

    2016-07-01

    Combigan (Allergan, Irvine, CA) is an ophthalmic solution that combines 0.2% brimonidine, a selective α-2 adrenergic agonist, with 0.5% timolol, a nonselective β-adrenergic antagonist. It is approved for the reduction of intraocular pressure in patients with glaucoma or ocular hypertension. There have been recent reports of successful treatment of superficial infantile hemangiomas (IHs) using Combigan topically. We report the case of a 2-month-old girl who developed life-threatening brimonidine toxicity requiring intubation and mechanical ventilation secondary to central nervous system depression and apnea after topical application to an ulcerated IH. © 2016 Wiley Periodicals, Inc.

  3. Hemangioma cavernoso e pediatria

    OpenAIRE

    Maria Teresa Luis; Janaína Sampaio Rosa; Izilda das Eiras Tâmega

    2007-01-01

    Os hemangiomas cavernosos fazem parte de um grupo extenso de lesões vasculares. Ocorrem em todas as faixas etárias, sendo mais comum em pessoas idosas e raramente em crianças; acometem mais mulheres que homens. Localizam-se freqüentemente na derme, podendo também comprometer estruturas mais profundas como subcutâneo, músculos, ossos, etc. Podem ser visíveis como ectasias ou tumores arroxeados localizados mais profundamente nas partes moles. São malformações que estão presentes desde o nascime...

  4. Tratamiento exitoso de un hemangioma de parótida con propranolol

    Directory of Open Access Journals (Sweden)

    Edelisa Moredo Romo

    2012-06-01

    Full Text Available Los hemangiomas infantiles son los tumores vasculares benignos más frecuentes en la infancia, que ocurren mayormente en los pacientes pretérmino, en un 80 % afectan cabeza y cuello, y en algunos pacientes provocan serias complicaciones para la vida. El hemangioma de parótida es una forma clínica de presentación en la que suele verse un período proliferativo prolongado con lenta involución. Se presenta el caso clínico de un paciente con diagnóstico de hemangioma de parótida con componente superficial y profundo, tratado con propranolol, con excelente respuesta al tratamiento, involución completa clínica e imaginológica del tumor en 10 semanas.

  5. Intestinal hemangioma presenting as recurrent hematochezia in a 6-week-old male

    Directory of Open Access Journals (Sweden)

    Grant A. Morris

    2015-07-01

    Full Text Available In infants, hematochezia must be approached with a broad differential diagnosis, including anal fissure, allergic colitis, Meckel's diverticulum, intestinal malrotation, necrotizing enterocolitis, and less commonly arteriovenous malformations, gastrointestinal duplications, and hemangiomas. Infantile hemangiomas, the most common tumor of infancy, are typically cutaneous lesions. Those arising from viscera are much less common but can cause significant morbidity and mortality if not diagnosed early and managed appropriately. We present a 6-week-old male with recurrent hematochezia who was initially diagnosed with milk protein intolerance but ultimately found to have a diffuse intestinal hemangioma. He was treated with propranolol, methylprednisolone, and exclusively parenteral nutrition. Repeat imaging suggested the lesion responded to pharmacotherapy and the patient is tolerating enteral nutrition.

  6. Radiotherapy of vertebral hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Sakata, Kohichi; Hareyama, Masato; Oouchi, Atushi; Sido, Mitsuo; Nagakura, Hisayasu; Tamakawa, Mituharu; Akiba, Hidenari; Morita, Kazuo [Dept. of Radiology, Sapporo Medical Univ., School of Medicine (Japan)

    1997-12-31

    Between 1975 and 1996, 14 patients (11 females, 3 males) with vertebral hemangioma received treatment with radiotherapy. Thirteen patients had a history of back pain or lumbago and 2 patients had neurological symptoms such as sensory impairment or paraplegia. The standard dose administered was 36 Gy in 18 fractions (five treatments per week). In the 13 patients with pain, this was completely or partially relieved. The condition of a man with hypesthesia of the legs deteriorated and a woman with paraplegia who was treated with decompressive laminectomy followed by radiotherapy recovered completely after irradiation. CT scan before irradiation showed thickened trabeculae as small punctate areas of sclerosis in all patients. At MR imaging before irradiation, T2-weighted MR images showed areas of high intensity in all patients and MR images demonstrated lesion enhancement. However, none of the patients who were treated successfully with radiation demonstrated any changes of the affected vertebra in the conventional radiographic films, CT scan or MR imaging, even 5 years after irradiation. Radiological imaging is indispensable for the diagnosis of vertebral hemangiomas but does not appear to be useful for evaluating the effects of radiotherapy. (orig.).

  7. Infantile Spasms

    Science.gov (United States)

    ... pattern on electroencephalography (EEG) testing called hypsarrhythmia (chaotic brain waves). The onset of infantile spasms is usually in ... pattern on electroencephalography (EEG) testing called hypsarrhythmia (chaotic brain waves). The onset of infantile spasms is usually in ...

  8. Critical hepatic hemangioma in infants: recent nationwide survey in Japan.

    Science.gov (United States)

    Kuroda, Tatsuo; Hoshino, Ken; Nosaka, Shunsuke; Shiota, Yohko; Nakazawa, Atsuko; Takimoto, Tetsuya

    2014-06-01

    The International Society for the Study of Vascular Anomalies (ISSVA) classification divides vascular lesions into two major entities: neoplasms originating from the vascular endothelium and vascular malformations. Although this concept has been widely accepted, little has been established regarding vascular lesions in deep organs, such as infantile hepatic hemangioma (IHH). The current nationwide survey identified 19 critical infantile hemangiomas during the most recent 5 years. On histopathology all the lesions examined were neoplastic, but portovenos shunt was found histologically or clinically in some cases. High-output cardiac failure, consumption coagulopathy, and respiratory distress were the major symptoms, and treatment-resistant coagulopathy seemed to be the most reliable predictor of fatal outcome. Although steroid has been the gold standard treatment for these lesions, 25% of the patients were totally insensitive to steroids, whereas propranolol had a prompt effect in one case. For critical IHH with steroid-insensitive thrombocytopenia and prothrombin time prolongation, novel therapeutic options including beta-blocker therapy, surgery, and liver transplantation should be urgently considered as alterative treatment. The present review summarizes the results of the survey. © 2014 Japan Pediatric Society.

  9. Parenteral corticosteroids followed by early surgical resection of large amblyogenic eyelid hemangiomas in infants

    Directory of Open Access Journals (Sweden)

    El Essawy R

    2013-05-01

    Full Text Available Rania El Essawy,1 Rasha Essameldin Galal21Department of Ophthalmology, 2Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, EgyptBackground: The purpose of this study was to evaluate the results and complications of early surgical resection of large amblyogenic subdermal eyelid hemangiomas in infants after prior short-term parenteral administration of corticosteroids.Methods: Sixteen infants were given dexamethasone 2 mg/kg/day in two divided doses for three consecutive days prior to scheduled surgical excision of large eyelid hemangiomas. The lesions were accessed via an upper eyelid crease, subeyebrow incision, or a lower eyelid subciliary incision.Results: In all cases, surgical excision of the entire lesion was possible with no significant intraoperative or postoperative complications. The levator muscle/aponeurosis complex was involved in 31.25% of cases and was managed by reinsertion or repositioning without resection. A satisfactory lid position and contour with immediate clearing of the visual axis was achieved in all but one case (93.8%.Conclusion: Parenteral corticosteroids helped in reducing volume and blood flow from the hemangiomas, allowing for very early total excision of large subdermal infantile hemangiomas without significant intraoperative hemorrhage. This resulted in immediate elimination of any reason for occlusion amblyopia. Long-term follow-up of visual development in these patients would help to demonstrate the effectiveness of this strategy compared with more conservative measures.Keywords: large eyelid hemangiomas, early surgical resection, parenteral corticosteroids

  10. Intramuscular capillary-type hemangioma: radiologic-pathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Yilmaz, Sabri; Alomari, Ahmad I.; Chaudry, Gulraiz [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Division of Vascular and Interventional Radiology, Boston, MA (United States); Kozakewich, Harry P. [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Department of Pathology, Boston, MA (United States); Fishman, Steven J. [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Department of Surgery, Boston, MA (United States); Mulliken, John B. [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Department of Plastic and Oral Surgery, Boston, MA (United States)

    2014-05-15

    Infantile hemangiomas demonstrate a pattern of proliferative growth in infancy followed by a slow phase of involution. In contrast a rare type of vascular tumor, intramuscular capillary-type hemangioma, usually presents beyond the period of infancy with nonspecific symptoms and no evidence of involution. The purpose of this study was to characterize the clinical, imaging, histopathological characteristics and management of intramuscular capillary-type hemangioma. We performed a retrospective review of a 20-year period to identify children diagnosed with intramuscular capillary-type hemangioma. Patient demographics, imaging and histopathological findings were recorded. We included 18 children (10 boys, 8 girls) with histologically proven intramuscular capillary-type hemangioma - and adequate imaging. The mean age at presentation was 8.1 years (range 1 day to 19 years). Twelve lesions involved muscles of the extremities, 4 were located in the trunk and 2 were in the head and neck. MRI had been performed in all children and demonstrated a soft-tissue mass with flow voids, consistent with fast flow. The lesion was well-circumscribed in 16 children and intralesional fat was seen in 14. Doppler US demonstrated a heterogeneous lesion, predominantly isoechoic to surrounding muscle, with enlarged arterial feeders. Enlarged feeding arteries, inhomogeneous blush and lack of arteriovenous shunting were noted on angiography (n = 5). The most common histopathological findings were lobules of capillaries with plump endothelium and at least some adipose tissue. The lesions were excised in six children. Two children were lost to follow-up. In the remaining 10, follow-up MRI studies ranging from 3 months to 10 years showed that the lesion enlarged in proportion to the child (n = 7), demonstrated slow growth (n = 2) or remained stable (n = 1). There was no change in imaging characteristics on follow-up. Intramuscular capillary-type hemangioma is a rare benign vascular tumor of

  11. Peritumoral Hyperplasia in Hepatic Sclerosed Hemangioma

    OpenAIRE

    Shimada, Seitarou; Tajiri, Kazuto; Baba, Hayato; Minemura, Masami; Tsuneyama, Koichi; Nakano, Masayuki; Sugiyama, Toshiro

    2017-01-01

    Peritumoral hyperplasia (PTH) is a hyperplastic lesion located around hypervascular tumors. Hepatic sclerosed hemangioma is a very rare form of hemangioma with sclerotic changes and is distinct from sclerosing hemangioma. We present a patient with non-alcoholic steatohepatitis-induced cirrhosis who presented with a hypervascular tumor. The tumor showed atypical findings of hemangioma and was treated with surgical resection because hepatic malignancy could not be ruled out. Histopathologic exa...

  12. Large destructive facial hemangioma in PHACE syndrome

    Directory of Open Access Journals (Sweden)

    Nagdeve N

    2009-01-01

    Full Text Available We report an infant who presented with large facial hemangioma associated with Dandy-Walker cyst and atrial septal defect. This case is peculiar in that the large facial hemangioma in posterior fossa malformations, hemangiomas, arterial anomalies, coarctation of aorta and other cardiac defects (PHACE syndrome resulted in massive tissue destruction.

  13. Sclerotherapy of Intraoral Superficial Hemangioma

    Directory of Open Access Journals (Sweden)

    Resmije Ademi Abdyli

    2016-01-01

    Full Text Available Hemangioma is the clinical term for a benign vascular neoplasm due to proliferation of the endothelial lining of blood vessels. Their most frequent location is the body skin and oral mucosa. One of the treatment modalities for hemangiomas is intralesional injection of sclerosing agents which cause the damage of blood vessels followed by their obliteration. The objective of the study was to describe the facility of application and evaluate the efficiency of sclerotherapy with aethoxysklerol 1%. Method. The case presented with intraoral submucosal hemangioma of the cheek was treated by intralesional injection of aethoxysklerol 3% diluted in water for injections at a 4 : 1 ratio (0.75% at the first appointment and 3 : 1 (1% at the second appointment. The effect of sclerotherapy was evaluated on the following visits in time intervals of two weeks. Results. The hemangioma disappeared without complications after the second injection of aethoxysklerol 1%. The successful results of the study were comparable to the data of literature with variations according to the used sclerosant agent, its concentration, the number of injections, and the intervals between each session. Conclusion. Since sclerotherapy is a very effective, inexpensive, and easy-to-apply treatment, it should be the treatment of choice, especially for intraoral superficial hemangiomas.

  14. Sclerotherapy of Intraoral Superficial Hemangioma.

    Science.gov (United States)

    Ademi Abdyli, Resmije; Abdyli, Yll; Perjuci, Feriall; Gashi, Ali; Agani, Zana; Ahmedi, Jehona

    2016-01-01

    Hemangioma is the clinical term for a benign vascular neoplasm due to proliferation of the endothelial lining of blood vessels. Their most frequent location is the body skin and oral mucosa. One of the treatment modalities for hemangiomas is intralesional injection of sclerosing agents which cause the damage of blood vessels followed by their obliteration. The objective of the study was to describe the facility of application and evaluate the efficiency of sclerotherapy with aethoxysklerol 1%. Method. The case presented with intraoral submucosal hemangioma of the cheek was treated by intralesional injection of aethoxysklerol 3% diluted in water for injections at a 4 : 1 ratio (0.75%) at the first appointment and 3 : 1 (1%) at the second appointment. The effect of sclerotherapy was evaluated on the following visits in time intervals of two weeks. Results. The hemangioma disappeared without complications after the second injection of aethoxysklerol 1%. The successful results of the study were comparable to the data of literature with variations according to the used sclerosant agent, its concentration, the number of injections, and the intervals between each session. Conclusion. Since sclerotherapy is a very effective, inexpensive, and easy-to-apply treatment, it should be the treatment of choice, especially for intraoral superficial hemangiomas.

  15. Pregnancy related symptomatic vertebral hemangioma

    Directory of Open Access Journals (Sweden)

    Meena Gupta

    2014-01-01

    Full Text Available Vertebral hemangiomas are benign vascular tumors of the spine that remain asymptomatic in most cases and incidentally encountered on imaging. Rarely, altered hemodynamic and hormonal changes during pregnancy may expand these benign lesions resulting in severe cord compression. The management of symptomatic vertebral hemangioma during pregnancy is controversial as modalities like radiotherapy and embolization are not suitable and surgery during pregnancy has a risk of preterm labor. Few cases of pregnancy related symptomatic vertebral hemangioma with marked epidural component have been reported in the literature. We report a case of 23-year-old primigravida who developed rapidly progressive paraparesis at 28 weeks of gestation and spine magnetic resonance imaging (MRI revealed upper thoracic vertebral hemangioma with extensive extra-osseous extension and spinal cord compression. Laminectomy and surgical decompression of the cord was performed at 32 weeks of the pregnancy. There was significant improvement in muscle power after a week of surgery. Six weeks postoperatively she delivered a full term normal baby with subsequent improvement of neurologic deficit. Repeat MRI of dorsal spine performed at 3 months postoperatively showed reduced posterior and anterior epidural components of vertebral hemangioma.

  16. Benign Mass in Tonsil- Cavernous Hemangioma

    Science.gov (United States)

    Joseph, Sumitha; Prakash, M.; Mohammed, Hafida K; Govar, Aberna

    2013-01-01

    Cavernous hemangioma is also called as ‘ANGIOMA CAVERNOSUM’ or ‘CAVERNOMA’ as benign lesion of blood vessels. They are similar to strawberry hemangioma but deeply situated. Although most often associated with skin it is also sometimes found in mucous membrane, brain and the viscera. The diagnosis of hemangiomas is mainly based on clinical evaluation . Isolated hemangiomas in the tonsillar tissue is a rare occurance. In this we report had a case of adult tonsillar hemangioma of left side associated with recurrent tonsillitis . He was effectively managed surgically without any complications. PMID:24298502

  17. Hemangioma cavernoso e pediatria

    Directory of Open Access Journals (Sweden)

    Maria Teresa Luis

    2007-05-01

    Full Text Available Os hemangiomas cavernosos fazem parte de um grupo extenso de lesões vasculares. Ocorrem em todas as faixas etárias, sendo mais comum em pessoas idosas e raramente em crianças; acometem mais mulheres que homens. Localizam-se freqüentemente na derme, podendo também comprometer estruturas mais profundas como subcutâneo, músculos, ossos, etc. Podem ser visíveis como ectasias ou tumores arroxeados localizados mais profundamente nas partes moles. São malformações que estão presentes desde o nascimento, geralmente de forma incipiente, e se manifestam clinicamente de forma proporcional ao crescimento da criança ou sob alterações hormonais ou de pressão. Relatamos o caso de uma menina de 10 anos e 8 meses com queixa de um nódulo abdominal doloroso há um mês. A dor ocorria, principalmente, quando a criança corria ou andava, melhorando quando em repouso. Nega uso de medicamentos e outros sintomas acompanhando o quadro. Ao exame físico apresentava uma massa palpável no abdome em flanco direito, medindo 3,0 x 1,0 cm, aderida aos planos profundos, de superfície lisa, doloroso à palpação; massa palpável na região lombar à esquerda medindo 2,0 x 1,0 cm. O restante do exame físico mostrava-se sem alterações. Em relação ao exames subsidiários foi solicitada ultra-sonografia de abdome total. Mostrou-se dentro da normalidade com achado adicional de três imagens nodulares hipoecóicas em nível do flanco direito, sendo duas proximais e uma mais lateralizada, que segundo o laudo pareciam corresponder a linfonodos mesentéricos aumentados de volume medindo, respectivamente, 1,5 x 0,5 cm, 1,4 x 0,5 cm e 1,2 x 0,5 cm. Tomografia computadorizada de pelve e abdome compatível com a normalidade. Foi encaminhada ao cirurgião pediátrico para realização de biópsia das massas. O exame anátomo-patológico da lesão mostrou como diagnóstico hemangioma cavernoso. Adotou-se uma conduta de controle do quadro através de exame ultra

  18. Recent progress of choroidal hemangioma

    Directory of Open Access Journals (Sweden)

    Li Miao

    2013-04-01

    Full Text Available Choroidal hemangioma(CHis a benign vascular tumor that occurred in the fundus posterior pole. Although it is a benign tumor, exudation from the lesion can lead to retinal detachment and other complications that make visual loss for patients. CH can occur as a circumscribed choroidal hemangioma(CCH, generally without systemic associations, or as a diffuse choroidal hemangioma(DCHthat is often associated variations of Sturge-weber syndrome(SWS. The management of CH has included laser photocoagulation, radiation therapy, transpupillary thermotherapy(TTT, photodynamic therapy(PDT. This article aims to introduce the current situation and the latest progress of the various therapies, to explore the most safe and effective method for the treatment of CH.

  19. Symptomatic vertebral hemangiomas during pregnancy.

    Science.gov (United States)

    Moles, Alexis; Hamel, Olivier; Perret, Christophe; Bord, Eric; Robert, Roger; Buffenoir, Kevin

    2014-05-01

    Symptomatic vertebral hemangiomas during pregnancy are rare, as only 27 cases have been reported in the literature since 1948. However, symptomatic vertebral hemangiomas can be responsible for spinal cord compression, in which case they constitute a medical emergency, which raises management difficulties in the context of pregnancy. Pregnancy is a known factor responsible for deterioration of these vascular tumors. In this paper, the authors report 2 clinical cases of symptomatic vertebral hemangiomas during pregnancy, including 1 case of spontaneous fracture that has never been previously reported in the literature. The authors then present a brief review of the literature to discuss emergency management of this condition. The first case was a 28-year-old woman at 35 weeks of gestation, who presented with paraparesis. Spinal cord MRI demonstrated a vertebral hemangioma invading the body and posterior arch of T-3 with posterior epidural extension. Laminectomy and vertebroplasty were performed after cesarean section, allowing neurological recovery. The second case involved a 35-year-old woman who presented with spontaneous fracture of T-7 at 36 weeks of gestation, revealing a vertebral hemangioma with no neurological deficit, but it was responsible for pain and local instability. Treatment consisted of postpartum posterior interbody fusion. With a clinical and radiological follow-up of 2 years, no complications and no modification of the hemangiomas were observed. A review of the literature reveals discordant management of these rare cases, which is why the treatment course must be decided by a multidisciplinary team as a function of fetal gestational age and maternal neurological features.

  20. Manejo del enoftalmos como secuela de fracturas del complejo cigomático-orbitario con apoyo de estereolitografía

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    H.

    Full Text Available El enoftalmos postraumático se define como la discrepancia entre el volumen orbitario y su contenido; este balance puede verse alterado por múltiples factores, como el secuestro tardío del contenido orbitario por atrapamiento en el sitio de la fractura, herniación del contenido orbitario, necrosis del tejido adiposo orbitario, contracción cicatricial del tejido retrobulbar, pérdida del sistema de suspensión ligamentario del globo ocular y aumento de volumen de la cavidad orbitaria. El presente estudio aborda el problema del enoftalmos postraumático como una deformidad difícil de corregir. Están descritos abordajes cutáneos extensos como el coronal, el subciliar o el intraoral; la técnica descrita por Henry Kawamoto en 1998 describe un procedimiento de menor invasión mediante abordajes de mínima exposición que permiten la refracturación y el alineamiento del cuerpo zigomático, brindando así grandes ventajas sobre las técnicas convencionales. Presentamos el método aplicado en el servicio de Cirugía Reconstructiva del Centro Médico del Instituto de Seguridad Social del Estado de México y Municipios (ISSEMyM para el manejo de pacientes con enoftalmos como secuela de traumatismos del complejo cigomático-malar; para ello empleamos un método por asistencia con modelos estereolitográficos para la planificación quirúrgica del diseño de osteotomías para corregir la deformidad facial y para determinar las dimensiones del defecto a reparar, así como el tipo y cantidad de materiales aloplásticos o autólogos a emplear. Compartimos la experiencia de los casos tratados en nuestro Servicio entre 2006 y 2010.

  1. Infantile sexuality

    DEFF Research Database (Denmark)

    Zeuthen, Katrine Egede; Gammelgård, Judy

    2010-01-01

    When first presented, Freud´s theory of infantile sexuality was a scandal. Not only was the claim that the small child sucking at the mother´s breast experiences a kind of pleasure that Freud without hesitation named sexual, the theory also turned the common understanding of human sexuality up...... vision of the sexual. Following a historic outline, we examine the theories that inspired by Laplanche, once more discuss infantile sexuality, and argue that infantile sexuality is clarified by combining the concept of the drive with what in effect is an inter-subjective point of view....

  2. [Hepatic hemangioma: the choice of treatment].

    Science.gov (United States)

    Aksenov, I V; Fedorchenko, A N

    2010-01-01

    117 patients with hepatic hemangioma were treated. 17 patients were operated on with the use of laser and plasmic scalpel. The possibility and technical features of liver resections by hepatic hemangiomas are discussed. In 8 of 17 operated patients, endovascular hemangiomatous vessel occlusion was effective. Authors state the necessity of reduction of surgical treatment of hepatic hemangiomas and substantiate the need of dynamic observation of such lesions of the liver.

  3. Synovial Hemangioma in the Knee: MRI Findings

    Directory of Open Access Journals (Sweden)

    Harun Arslan

    2015-01-01

    Full Text Available Synovial hemangiomas are rare benign tumors of vascular origin. A 23-year-old boy presented with knee pain and swelling. The boy had developed symptoms 18-months earlier. He was diagnosed with synovial hemangioma based on magnetic resonnance imaging examination and histopathologic findings of the arthroscopic biopsy tissue. We present the magnetic resonance imaging and histopathologic findings of synovial hemangioma of the knee.

  4. Rubinstein Taybi syndrome with hepatic hemangioma.

    Science.gov (United States)

    Sahiner, U M; Senel, S; Erkek, N; Karacan, C; Yoney, A

    2009-01-01

    It was the aim of our study to present a case of Rubinstein Taybi syndome (RTS) associated with hepatic hemangioma. A 6.5-year-old boy was diagnosed with RTS. He had large areas of cutaneous capillary hemangiomas. Radiological examination revealed a hepatic hemangioma. A multidisciplinary follow-up program was commenced and hepatic ultrasound examinations were performed periodically. No progression and complication have since occurred. This case shows an association between RTS and hepatic hemangioma, and hence, we recommend regular hepatic ultrasound examination when RTS is suspected or diagnosed. Copyright 2009 S. Karger AG, Basel.

  5. Nasopharyngeal Hemangioma in Adult: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Khil, Eun Kyung; Hong, Hyun Sook; Park, Ji Sang; Chang, Kee Hyun; Kim, Hee Kyung; Byun, Jang Yul [Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon (Korea, Republic of)

    2013-03-15

    Nasopharyngeal masses are usually malignant, and benign nasopharyngeal tumors such as hemangioma are unusual. In adults, hemangiomas do not involute spontaneously, but progress. Imaging modalities are useful to rule out other malignancies and vascular lesions and to evaluate the lesion. Most hemangiomas require no therapy, but certain factors such as age of the patient and location and size of the lesion may make treatment necessary. We report a case of an unusual nasopharyngeal hemangioma treated with endoscopic excision in an adult who complained of hearing loss.

  6. Effect of laser therapy on plasma expression of VEGF and bFGF in infants with cutaneous hemangioma.

    Science.gov (United States)

    Wang, Fagang; Xu, Rongjian; Xu, Qian; Cao, Yongqian; Lin, Li; Dang, Wei

    2017-03-01

    The present study aimed to investigate the effect of laser therapy on the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the plasma of infants diagnosed with cutaneous hemangioma, in order to identify biomarkers for assessing the clinical efficacy of laser therapy. In total, 109 infants with superficial abdominal hemangioma received laser treatment, of which 74 were diagnosed in the proliferation phase, 20 in the regression phase and 15 in the involution phase. In addition, 10 infants without cutaneous hemangioma were recruited as normal controls. The concentrations of VEGF and bFGF in peripheral plasma samples were measured using ELISAs. Dynamic changes in the VEGF and bFGF concentrations of 23 infants diagnosed in the proliferation phase were compared before and after laser therapy. The plasma concentration of VEGF in the proliferation phase group was significantly higher compared with that in the regression phase, involution phase and normal control groups (all P0.05). The plasma concentration of bFGF in the proliferation phase group was significantly higher compared with that in the regression phase, involution phase and normal control groups (all P0.05). Following laser therapy, the plasma concentrations of VEGF and bFGF in infants with cutaneous hemangioma were significantly decreased (both Plaser therapy for treating infantile cutaneous hemangioma.

  7. Hemangiomas. Novas Terapêuticas!

    OpenAIRE

    Salva, I; Brito, MJ

    2011-01-01

    Introdução: Os hemangiomas constituem a neoplasia mais frequente na criança, ocorrendo em 10-12%, na maioria dos casos com evolução favorável. A fase proliferativa, ocorre nos primeiros 4-6 meses e depois involuem em 50% dos casos, até aos 5 anos. Em hemangiomas de grandes dimensões e que interferem na função de outros órgãos, associam-se frequentemente complicações, nomeadamente a ulceração (10-15%), sobre-infecção bacteriana ou hemorragia. Descrição de Caso Clínico: Crianç...

  8. INTRALESIONAL TRIAMCINOLONE ACETONIDE INJECTION ON EYELID CAPILLARY HEMANGIOMA (Case Report

    Directory of Open Access Journals (Sweden)

    P Yuliawati

    2013-09-01

    Full Text Available Background: Infantile capillary hemangioma or benign hemangio-endotelioma or strawberry nevus is a most common benign vascular tumor in children. This study aims to report management two cases of eyelid capillary hemangioma with intralesional injection of triamcinolone acetonide (TA.Methods: Case report. First case is 11th months old baby, girl, with mass on right superior eyelid since 5th month old that getting bigger. Mass are soft, blue to purple colored, with size of 30 x 30 x 20 mm, obvious border, refined surface, fixated to beneath structure, and there were dilated blood vesselsvisible from anterior surface. Second case is 1st month old baby with mass on left superior eyelid since a week after birth. On examination found soft mass with blue violet colour, size 30x30x5mm, smooth surface, fixated, dilated blood vessels at skin surface. There were multiple bright red marks withvariated size such as 2x3x1mm, 2x2 x1mm, 3x2x1mm at eyelid skin surface. Both cases were given timol 0.5% for two months, but mass were getting bigger until closing visual axis. On both cases there were mechanical ptosis that close visual axis. Closing of visual axis causes deprivational amblyopia,so need intervention to reduces deprivation with intralesion TA injection at dose 3 mg/kg body weight.Results: After TA intralesional injection, tumor size reduced on both cases so visual axis is opened, without side effect. Conclusion: triamcinolone acetonide intralesional injection on capillary hemangioma cases reduces tumor size on relatively short time, in the hope to maximally reduce deprivation amblyopia at visual development age.Conclusion: triamcinolone acetonide intralesional injection on capillary hemangioma cases reduces tumor size on relatively short time, in the hope to maximally reducedeprivation amblyopia at visual development age.

  9. Quiescent Volcano-Chest Wall Hemangioma.

    Science.gov (United States)

    Saldanha, Elroy; Martis, John J S; Kumar, B Vinod; D'Cunha, Rithesh J; Vijin, V

    2017-08-01

    Chest wall hemangiomas are rare tumors that may originate within the soft tissue or from the ribs. Intramuscular hemangioma is infrequent, representing less than 1 % of all hemangiomas, and the localization in the chest wall is even less frequent. They are typically cutaneous in location, large, and poorly circumscribed and can be locally destructive. We present a case of a 34-year-old lady presented with firm lump 3 × 3 cm in left upper and inner quadrant of left breast well defined borders, non-pulsatile and restricted mobility. Sono-mammogram was suggestive of ill-defined lesion at 10 o'clock position. CT chest was conclusive of chest wall hemangioma. The patient underwent excision of the lump. HPE was suggestive of cavernous hemangioma. Cavernous hemangioma typically manifest at birth or before the age of 30 years. CT is more sensitive than plain radiography in detecting phleboliths, which are present in approximately 30 % of cavernous hemangiomas. Surgical excision would be treatment of choice. In this case, the site of the lesion was in the breast clinically mimicking that of a fibroadenoma which warrants hemangioma as a differential diagnosis.

  10. Literatura infantil :

    OpenAIRE

    Lajo Maide, Marta

    2012-01-01

    Se ve la definición, los orígenes e historia de la literatura infantil. Se observa cómo ha evolucionado, desde sus inicios hasta ahora. Posteriormente, se hace alusión a los diferentes tipos de literatura infantil según su proceso de formación, para proseguir detallando las características o requisitos que deben tener los libros en aspectos como estructura, contenidos, etc. También se realiza un breve resumen acerca de las características de estos por edades y, por último, se hace un análisis...

  11. Vocal cord hemangioma in an adult

    Directory of Open Access Journals (Sweden)

    Muzaffer Kanlıkama

    2011-09-01

    Full Text Available Hemangioma is one of the most common benign tumors in the head and neck region. Laryngeal hemangiomas are benign vascular tumors of unknown etiology that arise from subglottic region with stridor in infants. This type also known as congenital laryngeal hemangioma, is the more common. Congenital hemangiomas occur usually in subglottic region and more frequent in girls. Laryngeal hemangioma in adults is a very rare condition and main symptom is hoarseness and breathing difficulties. Adult hemangiomas can be seen in different locations such as the epiglottis, aryepiglottic folds, arytenoids and false and true vocal cords. They are more often of cavernous form and cause hoarseness. In this report we present an adult patient with hemangioma of the left vocal fold and review the literature. Diagnostic investigation revealed a pink-purple mass which was extended from the anterior comissure to the posterior part of true vocal cord and false vocal cord, filling the ventricule and extending to supraglottic region. Direct laryngoscopy was performed, but the lesion was not excised because of its widespread extension in the larynx. J Clin Exp Invest 2010; 2(3: 323-326.

  12. Clinical Characteristics and Treatment Options of Infantile Vascular Anomalies.

    Science.gov (United States)

    Yang, Bin; Li, Li; Zhang, Li-xin; Sun, Yu-juan; Ma, Lin

    2015-10-01

    To analyze the clinical characteristics and treatment outcomes of vascular anomalies, and determine which therapy is safe and effective. The data of vascular anomalies pediatric patients who arrived at Beijing children's Hospital from January 2001 to December 2014 were analyzed retrospectively, including the influence of gender, age, clinical manifestation, diagnosis, treatment options, and outcomes. As to infantile hemangiomas, the outcomes of different treatments and their adverse reactions were compared. As to spider angioma and cutaneous capillary malformation, the treatment effect of 595 nm pulsed dye laser (PDL) is analyzed. A total number of 6459 cases of vascular anomalies were reclassified according to the 2014 ISSVA classification system. Among them, the gender ratio is 1:1.69, head-and-neck involved is 53.3%, the onset age within the first month is 72.4%, the age of initial encounter that younger than 6 months is 60.1%. The most common anomalies were infantile hemangiomas (42.6%), congenital hemangiomas (14.1%), and capillary malformations (29.9%). In treating infantile hemangiomas, laser shows the lowest adverse reactions rate significantly. Propranolol shows a higher improvement rate than laser, glucocorticoids, glucocorticoids plus laser, and shows no significant difference with propranolol plus laser both in improvement rate and adverse reactions rate. The total improvement rate of 595 nm PDL is 89.8% in treating spider angioma and 46.7% in treating cutaneous capillary malformation. The improvement rate and excellent rate of laser in treating cutaneous capillary malformation are growing synchronously by increasing the treatment times, and shows no significant difference among different parts of lesion that located in a body. Vascular anomalies possess a female predominance, and are mostly occurred in faces. Definite diagnosis is very important before treatment. In treating infantile hemangioma, propranolol is recommended as the first-line agent, and

  13. Computed tomographic appearances of hepatic hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Masahide; Onodera, Hiroyoshi; Oikawa, Masamichi; Ohta, Kei; Goto, Yoshio (Tohoku Univ., Sendai (Japan). School of Medicine)

    1984-02-01

    Fifteen patients with hepatic hemangioma (16 lesions) were examined by computed tomography (CT). CT appearances were classified into three groups. Initially the CT appearances of hepatic hemangioma was a well-defined and low density. Following contrast material injection, three lesions became hyperdense and two lesions became isodense as compared with surrounding normal liver parenchyma. And eight lesions showed early peripheral enhancement with delayed central opacification. As CT appearances of hepatic hemangioma is characteristic, CT is the procedure of choice to confirm the diagnosis.

  14. Lipoma or hemangioma: A diagnostic dilemma?

    Directory of Open Access Journals (Sweden)

    K Vinay Kumar Reddy

    2015-01-01

    Full Text Available Lipomas and hemangiomas are well-known benign lesions of the body. However, their occurrence in the oral cavity is rare. Lipoma accounts for 1-4% of benign neoplasms of mouth affecting predominantly the buccal mucosa, floor of mouth and tongue. Hemangiomas occur mostly on the lips, buccal mucosa, tongue, and palate. Lipomas when superficially placed show yellowish surface discoloration and hemangiomas usually have reddish blue to deep blue color. Here, we report an unusual case of benign tumor occurring in the buccal vestibule.

  15. Implantes orbitarios de HAP-200: Experiencia en 100 casos Orbital implants of HAP-200: Experience in 100 cases

    Directory of Open Access Journals (Sweden)

    Nereyda Martínez Suárez

    2002-06-01

    Full Text Available Exponemos nuestra experiencia en los primeros 100 casos, en los cuales utilizamos implantes orbitarios confeccionados en Cuba con hidroxiapatita porosa coralina (HAP-200, en el período comprendido entre 1995-2000. Nuestra casuística estuvo enmarcada entre los 5 y 65 años de edad, predominando los grupos de edades de 15 a 35 años con 63 casos, el 72 % correspondió al sexo masculino. Los traumatismos primaron como causa de pérdida del globo ocular (80 %. Efectuamos 5 tipos de técnicas quirúrgicas, 22 enucleaciones, 46 evisceraciones (26 con y 9 sin conservación corneal respectivamente, 11 con cuadrisección escleral y 32 reconstrucciones de cavidades antiguas (implantes secundarios. En la mayoría de los pacientes operados los síntomas y signos posoperatorios fueron locales y catalogados de ligeros, que desaparecieron en la primera semana. Observamos dentro de las complicaciones 12 dehiscencias conjuntivales, 10 exposiciones de los implantes, 2 hipercorrecciones, 1 hipocorrección y 1 quiste conjuntival. La gammagrafía orbitaria demostró crecimiento fibrovascular en la totalidad de los pacientes sometidos a dicha investigación. Los resultados cosméticos evaluados fueron la conservación del surco orbitario y la motilidad del muñón que se consideraron satisfactorios, así como la tolerancia al material implantado que fue buena en el 93 % de los casos al cabo de los 2,5 años.We explain our experience with the first 100 cases in whom orbital implants made in Cuba with coralline porous hydroxyapatite (PHA-200 were placed between 1995 and 2000. Our casuistics comprised patients aged 5-65. It was observed a predominance of the age groups 15-35 with 63 cases. 72 % were males. Traumas prevailed as the main cause of eyeball loss (80 %. 5 types of surgical techniques were performed: 22 enucleations, 46 eviscerations (26 with and 9 without corneal conservation, respectively, 11 with scleral cuadrisection and 32 reconstructions of old

  16. Hyalinized Hemangioma of the Liver: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Seong Hoon; Shin, Ji Yeol [Daegu Fatima Hospital, Daegu (Korea, Republic of); Kim, Jang Ho [Andong Hospital, Andong (Korea, Republic of)

    2008-12-15

    Hepatic hemangioma is one of the most frequent benign neoplasms of the liver. Yet, hyalinized hemangioma represents a regressed form of cavernous hemangioma, a very rare disease that has only been reported in two patients in Korea. Hyalinized hemangiomas are characterized by severe sclerosis and are occasionally misdiagnosed as malignancies. Hemangiomas have identifiable features on ultrasonography, computed tomography, and magnetic resonance imaging. However, the radiologic differential diagnosis is extensive and should include malignant tumors. We report a very rare case of hyalinized hepatic hemangioma and present a review of the literature

  17. Propranolol enhanced adipogenesis instead of induction of apoptosis of hemangiomas stem cells

    Science.gov (United States)

    Ma, Xiaorong; Zhao, Tinghui; Ouyang, Tianxiang; Xin, Shujia; Ma, Yueting; Chang, Mengling

    2014-01-01

    Propranolol has been widely used in treating infantile hemangiomas (IHs). But recurrence of IHs was found in some cases on cessation of propranolol treatment. The other is that Chinese individuals reacted to propranolol differently from American Whites. Whether the difference of sensitivity is due to the β adrenoceptor (β-AR) expression pattern of hemangioma initiating cells remains unclear. In the present study, we isolated hemangioma-derived stem cells (hemSCs) from proliferative IHs and analyzed the biological characteristics and β-AR expression pattern of hemSCs by immunostaining, Western blotting and multilineage differentiation assay as well. We also tested the effects of propranolol on hemSCs by evaluating VEGF expression, proliferation and apoptosis related parameters. Our results indicated that CD133+ hemSCs located pre-vascular in proiferative IH tissues. Both β1 and β2-AR were expressed, while β2-AR was dominant on hemSCs. Propranolol at 100-150 μM inhibited proliferation of hemSCs, not did 50 μM. Propranolol down-regulated VEGF expression of hemSCs, instead of inducing apoptosis. The adipogenic potential was enhanced by propranolol. Therefore, our current results suggested propranolol could not induce apoptosis of hemSCs, but played a curative role though suppressing VEGF synthesis and enhancement of adipogenesis of hemSCs. Our results might partially provide the insight of mechanism of relapse in some cases on cessation of propranolol treatment. PMID:25120757

  18. Propranolol Accelerates Adipogenesis in Hemangioma Stem Cells and Causes Apoptosis of Hemangioma Endothelial Cells

    Science.gov (United States)

    Wong, Alvin; Hardy, Krista L.; Kitajewski, Alex M.; Shawber, Carrie J.; Kitajewski, Jan K.; Wu, June K.

    2013-01-01

    Background Infantile hemangiomas (IHs) can cause significant morbidity during proliferation, yet there is no FDA-approved treatment. IHs are believed to form from stem cells (HemSCs), which differentiate towards an endothelial cell (HemECs) phenotype. Recently, propranolol has demonstrated effectiveness in the treatment of complicated IHs. We hypothesize that propranolol facilitates IH involution by altering cellular behavior in both HemECs and HemSCs. Methods HemECs and HemSCs were isolated from resected IH specimens. Cells were treated with 100μM propranolol for 48 hours, and apoptosis determined by presence of Annexin V antibody. Proliferation of HemSCs and HemECs were assessed after treatment with 50μM or 100μM propranolol, or vehicle for 72 and 96 hours respectively. Adipogenesis was induced in HemSCs with and without propranolol. Pro-adipogenic genes PPARδ, PPARγ, C/EBPα, C/EBPβ, C/EBPδ, RXRα and RXRγ were analyzed by quantitative PCR (qPCR). Results Annexin V levels were increased in propranolol-treated HemECs, but not in HemSCs. Proliferation of HemSCs and HemECs was inhibited by propranolol in a dose-dependent manner. Propranolol-treated HemSCs demonstrated accelerated adipogenesis when compared to untreated controls. Transcript levels of adipogenesis-associated genes C/EBPβ (ppropranolol, and C/EBPδ (ppropranolol. C/EBPα transcript levels remained unchanged at either dose. Conclusions These results show that propranolol increased apoptosis of HemECs but not HemSCs, and accelerated adipogenesis of HemSC. Thus, propranolol likely accelerates involution to fibrofatty residuum. PMID:23096601

  19. Breast Hemangioma: MR Appearance with Histopathological Correlation

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    Rasha Ameen

    2012-01-01

    Full Text Available Breast hemangioma is a rare tumor and when small, it may be difficult to diagnose using conventional imaging techniques. In this report the MR appearance is described with histopathological correlation.

  20. Intramuscular Hemangioma Mimicking an Adnexal Malignancy

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    Selen Dogan

    2013-10-01

    Full Text Available Intramuscular hemangiomas were defined as vascular malformations according to the International Society for the Study of Vascular Anomalies (ISSVA classification. Aggressive appearance on radiologic images but nonaggressive course of these lesions results in diagnostic challenge for the clinicians that are unfamiliar with these lesions. Here, we present a 49-year-old woman as a rare case of mixed type intramuscular hemangioma originating from pelvic floor muscles, mimicking a malignant adnexal mass.

  1. Update on the classification of hemangioma

    OpenAIRE

    Antony George; Varghese Mani; Ahammed Noufal

    2014-01-01

    Despite the fact that a biological classification of congenital vascular tumors and malformations was first published in 1982 by Mulliken and Glowacki, significant confusion still prevails due to the indiscriminate and interchangeable use of the terms hemangioma and vascular malformation. Hemangiomas are true neoplasms of endothelial cells and should be differentiated from vascular malformations which are localized defects of vascular morphogenesis. On an analysis of various scientific articl...

  2. Intramuscular Hemangioma Mimicking an Adnexal Malignancy

    OpenAIRE

    Selen Dogan

    2013-01-01

    Intramuscular hemangiomas were defined as vascular malformations according to the International Society for the Study of Vascular Anomalies (ISSVA) classification. Aggressive appearance on radiologic images but nonaggressive course of these lesions results in diagnostic challenge for the clinicians that are unfamiliar with these lesions. Here, we present a 49-year-old woman as a rare case of mixed type intramuscular hemangioma originating from pelvic floor muscles, mimicking a malignant adnex...

  3. Epitheloid hemangioma: A report of two cases

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    Basanti Devi

    2014-01-01

    Full Text Available We report two cases of epitheloid hemangioma presented with multiple nodular lesions over head and neck region. One of them gave history of bleeding on minor trauma. Pyogenic granuloma was considered as a differential diagnosis from the morphological appearance and history of bleeding. Nodular leprosy, sarcoidosis, and secondary syphilis were also considered. Histopathological examination of both was typical of epitheloid hemangioma, an entity commonly overlooked clinically due to its rarity.

  4. Multiple Epithelioid Hemangiomas with Orbital Involvement

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    Branislava Miličić

    2015-01-01

    Full Text Available Epithelioid hemangioma, also known as angiolymphoid hyperplasia with eosinophilia, is a cutaneous angioproliferative lesion that follows a benign clinical course. It is most frequently localized in the skin of the head and neck region; although it may sometimes arise deeper in soft tissues, orbital involvement is rare. Here we describe a patient who developed multiple epithelioid hemangiomas, including an intraorbital lesion. The histopathological parallels with other reactive and neoplastic lesions as well as therapeutic options are discussed.

  5. Intra-muscular hemangioma: A review

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    Shruti Nayak

    2014-01-01

    Full Text Available Intra-muscular hemangiomas (IMH are relatively uncommon benign vascular tumors, which account for less than 1% of all hemangiomas. IMH may be presented as a perceived sporting injury. Diagnosis of this lesion is important not only because of its rarity, but also due to dangers posed by misdiagnosis and mismanagement. They must be considered in the differential diagnosis of unexplained pain and swelling in muscles. IMH occurring in the oral cavity is reviewed below.

  6. Symptomatic vertebral hemangioma: Treatment with radiotherapy

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    Aich Ranen

    2010-01-01

    Full Text Available Background: Vertebrae are the second commonest site among skeletal locations affected by hemangioma, but only about one per cent becomes symptomatic throughout the life. Though surgery, intra vertebral injection of various sclerosing agents have been tried in treating this benign process, no general consensus regarding management has been reached. Radiotherapy is emerging as a low cost, simple, non-invasive but very effective modality of treatment of symptomatic vertebral hemangioma. Aim: This study aims to find out the role of external beam radiotherapy in alleviating the symptoms of symptomatic vertebral hemangiomas without compromising the quality of life. Materials and Methods: Seven consecutive patients with symptomatic vertebral hemangioma were treated with a fixed dose of external beam radiotherapy; and muscle power was assessed before, after treatment and during follow-up. Results: All patients showed improvement of muscle power, which increased with the passage of time. Pain relief with improvement of quality of life was obtained in all the patients. Conclusion: Effect of radiotherapy on vertebral hemangioma is dose-dependent and the dose limiting factor is the spinal cord tolerance. In the present era of IMRT, greater dose can be delivered to the parts of vertebra affected by the hemangioma without compromising the spinal cord tolerance and expected to give better results.

  7. Cavernous Hemangioma of the Rib: A Rare Diagnosis

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    Stavros Gourgiotis

    2010-01-01

    Full Text Available Hemangioma of the rib is an uncommon benign vascular tumour. A case of rib hemangioma in a 29-year-old woman is presented. Chest roentgenogram and computed tomography revealed a mass along the inner surface of the 7th left rib with bone destruction. She underwent resection of the 7th rib. The pathologic diagnosis was cavernous hemangioma. Hemangiomas of the rib are rare tumours but should be kept in mind in the differential diagnosis of rib tumours.

  8. Congenital infantile fibrosarcoma mimicking a cutaneous vascular lesion: a case report and review of the literature.

    Science.gov (United States)

    Enos, Tyler; Hosler, Gregory A; Uddin, Naseem; Mir, Adnan

    2017-02-01

    Congenital infantile fibrosarcoma (CIFS) is a rare neoplasm of infancy that occurs most frequently in the extremities, and when presenting in the skin, may sometimes resemble infantile hemangiomas or other vascular lesions. Clinically, these tumors differ from hemangiomas in the time of onset, morphology, and growth pattern and must be evaluated histologically for definitive diagnosis. We describe an infant with a neoplasm involving the distal left forearm initially presumed to be a vascular lesion after evaluation by two separate ultrasound studies. He presented at seven weeks of life with a multinodular lesion that had enlarged significantly since birth, and the skin biopsy revealed a fibrosarcoma. This case highlights an unusual cutaneous presentation of CIFS, which varies in appearance from the previous 12 cases reported in the literature. We review the clinical manifestations of these congenital masses and emphasize early diagnosis for conservative therapy and improved prognosis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  9. Current situation on radiofrequency ablation of hepatic hemangioma

    OpenAIRE

    Zou, Hua

    2013-01-01

    The recent progress in radiofrequency ablation (RFA) of hepatic hemangioma was reviewed, with a focus on radiofrequency electrodes, treatment modalities, complications, and prevention strategies. The foundation for the standardization of RFA of hepatic hemangioma was laid. The standardization of RFA will help to promote its clinical application and development as an important minimally invasive technique for hepatic hemangioma.

  10. Current situation on radiofrequency ablation of hepatic hemangioma

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    ZOU Hua

    2013-08-01

    Full Text Available The recent progress in radiofrequency ablation (RFA of hepatic hemangioma was reviewed, with a focus on radiofrequency electrodes, treatment modalities, complications, and prevention strategies. The foundation for the standardization of RFA of hepatic hemangioma was laid. The standardization of RFA will help to promote its clinical application and development as an important minimally invasive technique for hepatic hemangioma.

  11. Urethral cavernous hemangioma in a female patient: a rare entity ...

    African Journals Online (AJOL)

    Genitourinary hemangiomas are rare entities of the urinary system. We reported a female patient who suffered dyspareunia and intermitant hematuria that was proved as urethral cavernous hemangioma. Despite its benign nature, hemangiomas may recur due to incomplet excision. Pan African Medical Journal 2015; 22 ...

  12. Dynamic enhanced computed tomographic findings of a perirenal capillary hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Min; Kim, Sang Won; Kim, Hyun Cheol; Yang, Dal Mo; Ryu, Jung Kyu; Lim, Sung Jig [Kyung Hee University Hospital at Gangdong, Seoul (Korea, Republic of)

    2016-05-15

    Hemangiomas are benign mesenchymal neoplasms that rarely occur in the kidney and perirenal space. Perirenal hemangiomas can mimic the appearance of exophytic renal cell carcinoma or various retroperitoneal tumors. We report a case of perirenal hemangioma detected by dynamic enhanced computed tomography in a 43-year-old female.

  13. Hemangioma rubi no couro cabeludo Cherry hemangioma in the scalp

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    José Marcos Pereira

    2004-02-01

    Full Text Available O hemangioma rubi (HR é dermatose de origem vascular extremamente freqüente, acometendo mais de 75% da população acima de 70 anos de idade. Em geral compõe-se de lesões múltiplas,localizadas predominantemente no alto do tronco e braços. Clinicamente é caracterizado por lesões que variam desde máculas puntiformes até lesões papulosas com cinco milímetros de diâmetro. As mais novas são vermelhas, em tons vivos, e as mais antigas podem ser azuladas. O HR é de etiologia desconhecida. Histologicamente chama atenção uma neoformação de vasos capilares, que se tornam dilatados e com fenestrações em suas paredes. A membrana basal está muito espessada e existe abundante estroma de colágeno entre os vasos. O presente trabalho demonstra a alta incidência do HR no couro cabeludo Em amostra de 171 pacientes, sendo 85 homens e 86 mulheres, o autor observou que 123 deles (72% tinham HR no couro cabeludo, localização em que o HR nunca foi descrito na literatura.Cherry hemangioma (CH is an extremely frequent dermatosis with vascular origin involving more than 75% of the population over 70 years of age. Normally they are multiplex spots and focus predominantly on the upper trunk and arms. Clinically they are characterized by pinpoint maculae and papules with up to 5 millimeters in diameter. The most recent lesions can be a strong red color while the older ones are bluish. The etiology of CH is still unknown. From the histologic standpoint, the neoformation of the capillary tube draws attention: they are very dilated and with fenestration along the wall. The basement membranes are thickened and there is abundant collagen stroma between the veins. This work demonstrates the high frequency of CH in the scalp. In a sample of 171 patients (85 men and 86 women the author noted that 123 (72% had CH in the scalp. However, according to the literature, CH in the scalp has never been described.

  14. Ultrasonographic diagnosis of liver cavernous hemangioma

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    Lee, Hwang Bok; Jeon, Hae Jeong; Kim, Yoon Hwan; Seol, Hae Young; Kim, Jung Hyuk; Suh, Won Hyunk [Korea University College of Medicine, Seoul (Korea, Republic of)

    1987-12-15

    Hepatic hemangioma which is usually small in size and peripheral in location, is the most common benign tumor in the liver. It is less significant clinically because of its no specific symptoms. Hepatic hemangioma therefore, does not need specific treatment, but occasionally due to its large sized lesions, it must be differentiated from malignant tumors or other ominous hepatic lesions. The authors evaluated the ultrasonographic findings of 29 lesions of hepatic hemangioma and suggested diagnostic work-ups for the focal echogenic liver lesions. The results were as follows: 1. The size of tumor was less than 3cm in 27 lesions and more than 3cm in 2. 2. The hemangioma involved right lobe in 25 cases. 3. 26 lesions in 25 patients were seen as hyper echoic pattern and 3 lesions appeared as hypoechoic. 4. Posterior acoustic enhancement was noted in 2 cases of echogenic hemangioma 5. A sonographic follow-up is useful every 3 months in lesions that are less than 2cm, with a hyperechoic, sharply demarcated border. If the lesion is larger than 2cm, or small but hypoechoic mass, further evaluations with CT, angiography and biopsy are necessary

  15. Intraneural hemangioma of digital nerve diagnosed with MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kerimoglu, Ulku [Hacettepe University School of Medicine, Department of Radiology, Ankara (Turkey); Uzumcugil, Akin; Yilmaz, Guney; Ayvaz, Mehmet; Leblebicioglu, Gursel [Hacettepe University School of Medicine, Departments of Orthopaedics and Traumatology, Ankara (Turkey); Altinok, Gulcin [Hacettepe University School of Medicine, Department of Pathology, Ankara (Turkey)

    2007-02-15

    Hemangioma may occur at any location. Although the imaging findings of hemangioma are well known, it may be difficult to differentiate this entity from other soft-tissue tumors. Intraneural hemangiomas are extremely rare. We present a girl with a painful swelling in the fourth web space of her right hand. Since it was painful, the referring clinician considered the possibility of a glomus tumor. However, demonstration of dilated feeding or draining vessels suggested the diagnosis of hemangioma. At surgery a hemangioma of the ulnar digital nerve of the ring finger was resected marginally. (orig.)

  16. Hemangioma of the spermatic cord: a case report

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    Hamid Mazdak

    2006-12-01

    Full Text Available Hemangioma of the spermatic cord is a benign, extremely rare tumor. We report a case of spermatic cord hemangioma presenting with a painless mass in the left hemiscrotum. Physical examination revealed a non-tender non-transilluminating irregular mass in the left hemiscrotum, above and clearly separate from the left testis. After surgical removal of the mass arising from the spermatic cord, histologic examination showed a benign vascular tumor consistent with cavernous hemangioma. To our knowledge, only a few cases of spermatic cord hemangioma have been previously reported in the literature. KEY WORDS: Hemangioma, spermatic cord, scrotal mass.

  17. MR imaging of cerebral cavernous hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Shakudo, Miyuki; Inoue, Yuichi; Matsumura, Yasumasa and others

    1988-06-01

    Magnetic resonance imaging (MRI) and CT were performed on 16 lesions of 13 patients with cases of cavernous hemangioma (10 cases of a solitary lesion and 1 case of multiple lesions). Six of the 16 cavernomas were histologically confirmed. All the lesions were detected on enhanced CT scans; fifteen of the 16 lesions were detected on MR images. The cavernous hemangiomas showed various signal intensities on both T/sub 1/-weighted and T/sub 2/-weighted images. All lesions not associated with a fresh hematoma were circumscribed by a curvilinear low-intensity area, most prominently on T/sub 2/-weighted images. This low-intensity band around cavernous hemangiomas on T/sub 2/-weighted images seemed to represent the hemosiderin leiden peritumoral brain.

  18. Hepatic hemangiomas: pitfalls in scintigraphic detection

    Energy Technology Data Exchange (ETDEWEB)

    Good, L.I.; Alavi, A.; Trotman, B.W.; Oleaga, J.A.; Eymontt, M.J.

    1978-04-01

    The evaluation of solitary hepatic lesions detected on scintiscans is a commmon clinical problem. It is usually assumed that radionuclide rapid sequence flow studies and blood pool images are reliable and accurate methods of demonstrating the vascularity of hepatic lesions. Our recent experience with 3 patients with angiographically proven hepatic hemangiomas indicates that radionuclide techniques may fail to detect the vascularity of hemangiomas. We speculate that blood flow within a hepatic hemangioma may be sluggish and its vascularity may be appreciated only by arteriography. Therefore, we alert the clinician to assess the vascularity of solitary hepatic tumors by angiography before percutaneous liver biopsy and thereby avert the possibility of life-threatening exsanguination, as occurred in one of our patients.

  19. Ultrasonographic classification of Atypical hepatic hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Sang Jin; Kim, Pyo Nyun; Ha, Hyun Kwon; Lee, Moon Gyu; Auh, Yong Ho [College of Medicine, University of Ulsan, Seoul (Korea, Republic of); Yoon, Kwon Ha [Wonkwang University Hospital, Junju (Korea, Republic of)

    2000-02-01

    Cavernous hemangioma is the most common benign hepatic tumor. Typically, the most common features revealed by ultrasound (US) include its small size (4 cm or less in diameter), uniform hyperechogenicity, well defined margins, position in the subcapsular region of the right lobe of the liver, and some posterior echo enhancement. In addition, follow-up scanning may reveal changes in size, though this is rare. The US findings of hepatic hemangiomas may vary, however, especially when lesions are large and/or multiple. For that reason, differential diagnosis between this condition and hepatocellular carcinomas, metastatic lesions, lymphomas and other tumors is difficult. An understanding of the various sonographic findings of hepatic hemangioma can facilitate the early detection of the condition. (author)

  20. Intravitreal bevacizumab (avastin for circumscribed choroidal hemangioma

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    Subrata Mandal

    2011-01-01

    Full Text Available Circumscribed choroidal hemangiomas are rare ophthalmic entities that cause diminution in vision due to accumulation of subretinal and/or intraretinal fluid in the macular area. Various treatment options ranging from conventional laser to photodynamic therapy have been employed to destroy the tumor and reduce the exudation; however, either the inability to penetrate through the exudative fluid or the collateral retinal damage induced by these treatment modalities make them unsuitable for lesions within the macula. We evaluated the role of intravitreal bevacizumab, a pan-vascular endothelial growth factor (VEGF inhibitor, in reducing the sub- and intraretinal fluid in three patients with circumscribed choroidal hemangiomas. All the patients had complete resolution of the serous retinal detachment that was maintained till at least 12 months after the first injection. Intravitreal bevacizumab may be used in combination with thermal laser or photodynamic therapy in treating circumscribed choroidal hemangiomas with subretinal fluid.

  1. Reparación de fracturas de suelo orbitario con hidroxiapatita HAP-200 Repair of orbital floor fractures with HAP-200 hydroxyapatite

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    Juan Carlos Quintana Díaz

    2005-12-01

    Full Text Available Se realizó un estudio clínico y radiográfico pre y posoperatorio en 4 pacientes con fracturas del suelo orbitario reparadas con hidroxiapatita HAP-200. En ninguno de los pacientes se encontró reacción adversa ante este material implantalógico y sí muy buena tolerancia y adaptabilidad, lo que nos reafirmó su alta biocompatibilidad, por lo que lo recomendamos en el tratamiento de esta afección.A pre- and postoperative clinical and X-ray study was conducted in 4 patients with orbital floor fractures repaired with HAP-200hydroxyapatite. . No adverse reaction to this material was observed in any of the patients, who showed a good tolerance and adaptability that confirmed its high biocompatibility and make it recommendable for treating this affection.

  2. Transpupillary thermotherapy (TTT) in circumscribed choroidal hemangioma.

    Science.gov (United States)

    Fuchs, Anne V; Mueller, Arthur J; Grueterich, Martin; Ulbig, Michael W

    2002-01-01

    Choroidal hemangioma presents a therapeutic dilemma. Although it is a benign tumor, it may lead to massive exudation of subretinal fluid and a loss of visual function. Argon laser photo-coagulation in a grid pattern may be followed by initial absorption of subretinal fluid, but recurrence is common. Trans-scleral cryotherapy is difficult to apply at the posterior pole of the eye. External beam irradiation may bear a risk of maculopathy and papillopathy. Brachytherapy does not allow placement of radiation to the hemangioma sparing other retinal or choroidal structures. We sought to determine whether transpupillary thermotherapy (TTT) is suitable for treatment of choroidal hemangioma at the posterior pole. We present ten patients with choroidal hemangioma. All of these received TTT. The mean follow-up period was 13.3 months (3-21 months). TTT was delivered via a slitlamp microscope with a diode laser at 810 nm. After TTT, reduction in tumor prominence was observed in eight patients at 3 months after treatment by A scan sonography. Visual acuity improved by more than three lines in four patients, and remained unchanged in all other patients. Two patients were retreated to achieve complete absorption of fluid. Serous retinal detachment persisted in three patients because the hemangioma could not be treated completely because of proximity to the fovea. Our preliminary results suggest that TTT may be used effectively to treat some choroidal hemangiomas in the first instance and prevent fluid leakage provided the lesion does not involve the fovea. However, long-term follow-up and more cases are needed to evaluate the long-term visual outcome and potential risks.

  3. Infantile colic

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    Aleksandra Rurarz

    2016-12-01

    Full Text Available Infantile colic is one of the most common functional gastrointestinal disorders in infants, usually occurring between 2 weeks to 4 months of age. According to the definition, infantile colic is characterised by episodes of inconsolable crying, generally observed in the evening. Although these symptoms usually resolve spontaneously in the first six months of life, they often cause parental anxiety, leading to repeated medical appointments in search for help. Despite 40 years of research, the causes of this disorder are still unclear; hypersensitivity to cow’s milk protein, lactose intolerance, impaired gut microbiota, immaturity of the nervous system, the negative impact of tobacco smoke, inappropriate childcare techniques and psychosocial factors are believed to be involved in the pathogenesis. The treatment involves behavioural methods, i.e. reducing infant exposure to external stimuli. Breastfeeding mothers are advised to eliminate caffeine and hot spices from their diet and, in some cases, switch to a dairy-free diet. For formula-fed infants, it is recommended to use hydrolysates with a high degree of hydrolysis. Simethicone is commonly used in the pharmacological treatment as it reduces the surface tension of intestinal gases, enabling their easier elimination. The Rome III Diagnostic Criteria recommend to appropriately continue any method if considered effective by the parents, provided that there are no harmful consequences.

  4. Pediatric Nasal Lobular Capillary Hemangioma

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    Jordan M. Virbalas

    2012-01-01

    Full Text Available Background. LCH is a benign vascular growth of the skin and mucous membranes commonly affecting the head and neck. Since it was first described in the nineteenth century, this entity has been variously known as “human botryomycosis” and “pyogenic granuloma.” The shifting nomenclature reflects an evolving understanding of the underlying pathogenesis. We review the histopathology of and current epidemiological data pertaining to LCH which suggests that the development of these lesions may involve a hyperactive inflammatory response influenced by endocrine factors. We report two new cases of pediatric lobular capillary hemangioma (LCH of the nasal cavity and review current theories regarding the etiology, diagnosis, and treatment of nasal LCH. Methods. Retrospective case series. Case Series. Two adolescent females presented with symptoms of recurrent epistaxis, nasal obstruction, and epiphora. Both patients underwent computed tomography imaging and biopsy of their intranasal mass. The tumors were excised using image-guided transnasal endoscopic technique. Seven other cases of nasal LCH have been reported to date in the pediatric population. Conclusion. Nasal LCH is a rare cause of an intranasal mass and is associated with unilateral epistaxis, nasal obstruction, and epiphora. We advocate for image-guided endoscopic excision of LCH in the adolescent population.

  5. Hemangioma de úvula: relato de um caso

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    G. Sobrinho Fernando P.

    2003-01-01

    Full Text Available O hemangioma é o mais comum tumor de origem vascular, benigno, freqüentemente diagnosticado em crianças, e com predileção pela cabeça e pescoço, mas que raramente tem origem na úvula. Neste órgão, apresenta risco de traumatismo local e sangramento. Este artigo relato um caso de hemangioma de úvula num adulto jovem com disfagia orofaríngea progressiva e sensação de corpo estranho na garganta, tratado com sucesso por ressecção cirúrgica do tumor com bisturi de radiofreqüência.

  6. Intracerebral Capillary Hemangioma: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Youn, In Young; Kim, Jae Kyun; Byun, Jun Soo [Dept. of Radiology, Chung Ang University Medical Center, Chung Ang University College of Medicine, Seoul (Korea, Republic of); Park, Eon Sub [Dept. of Radiology, Chung Ang University Medical Center, Chung Ang University College of Medicine, Seoul (Korea, Republic of)

    2012-01-15

    Intracerebral capillary hemangiomas are very rare benign vascular tumors that mostly occur during infancy. We described a 69-year-old man with generalized tonic-clonic seizures who was diagnosed with an intracranial mass. Multidetector computed tomography, magnetic resonance imaging and digital subtraction angiography studies were performed for evaluation of brain, and there was a well-enhancing mass found in the right temporal lobe without a definite feeding vessel. The patient underwent surgery and the pathologic examination demonstrated marked proliferation of small vessels with a lobular pattern in the brain parenchyma, which was confirmed to be capillary hemangioma.

  7. Uncommon scintigraphic findings of multiple hepatic hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    el-Desouki, M.; Joharjy, I.A.; al-Muzrakchi, A.M.; Bashi, S.A. (King Saud Univ., Riyadh, (Saudi Arabia))

    1991-03-01

    Tc-99m labeled red blood cell scintigraphy is a valuable, noninvasive technique for differentiating hepatic hemangioma from other lesions by demonstrating a 'perfusion blood pool mismatch.' The characteristic finding on dynamic CT scan of peripheral and subsequent central enhancement is not usually seen on Tc-99m RBC angiography, probably due to rapid mixing and dilution of the radionuclide and low resolution of the gamma camera. A case of multiple hepatic hemangioma is presented in which Tc-99m RBC dynamic angiography demonstrated peripheral enhancement with subsequent central filling. In addition, delayed static images showed more hepatic lesions.

  8. Giant hepatic hemangioma versus conventional hepatic hemangioma: clinical findings, risk factors, and management.

    Science.gov (United States)

    Moctezuma-Velázquez, C; López-Arce, G; Martínez-Rodríguez, L A; Escalona-Huerta, C; Chapa-Ibargüengoitia, M; Torre, A

    2014-01-01

    Giant hepatic hemangiomas (GHHs) are those that are larger than 4 cm in size. The aim of this study was to describe GHH clinical findings, their risk factors, diagnostic approach and management, and to compare these data with those of conventional hemangiomas. We performed a retrospective analysis of patients diagnosed with hemangiomas, whether by imaging studies or histopathology, at our hospital within the time frame of 1990-2008. The medical records of each patient were reviewed to obtain clinical and surgical data. Of the 57 patients with liver hemangioma, 41 (72%) were women and 32 (56%) had GHH. Liver hemangioma median size was 4.49 cm. In regard to the patients with GHH, 31.2% were asymptomatic and when symptoms presented, pain was the most common. Both symptoms and oral contraceptive exposure were more common in the GHH patients. Nine patients with GHH underwent surgery: 2 open biopsies due to diagnostic uncertainty, one enucleation, and 6 resections. GHHs are more prevalent in women and when symptomatic, pain is the most frequent complaint. Diagnosis is usually made through imaging studies, but when there is diagnostic doubt, surgical exploration is sometimes needed. Oral contraceptive use is most likely more of a risk factor for GHH than for conventional hemangioma, but this association needs to be studied further. Copyright © 2014 Asociación Mexicana de Gastroenterología. Published by Masson Doyma México S.A. All rights reserved.

  9. les hemangiomes vertebraux agressifs vertebral hemangiomas

    African Journals Online (AJOL)

    Background 1. Vertebral hemangiomas are benign tumeurs and are raré< ly symptomatic Aggressive forms represent less than. 1% of all cases Medical imaging allows both diagnosis ... '+ tro'ubles sphinctêriens. Irritation pyramidale '. Laminectomie - échec [saignement important) embolieationcomplêtée par une résection.

  10. A rapidly enlarging cutaneous hemangioma in pregnancy

    Directory of Open Access Journals (Sweden)

    Marwan Ma’ayeh

    2014-10-01

    Full Text Available This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient’s thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor.

  11. SPECT in the diagnosis of hepatic hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Brunetti, J.C.; Van Heertum, R.L.; Yudd, A.P.

    1985-05-01

    Tc99m labeled red blood cell blood flow and delayed static blood pool imaging is widely accepted as a reliable, accurate method for the diagnosis of hepatic hemangiomata. The purpose of this study is to assess the relative value of SPECT blood pool imaging in the evaluation of hepatic hemangionata. A total of 68 patients, including 21 patients with proven hepatic cavernous hemangiomas, were studied using both planar and SPECT imaging techniques. All patients underwent multi-phase evaluation which included a hepatic flow study, immediate planar images of the liver, followed by a 360/sup 0/ tomographic (SPECT) study and subsequent 60 minute delayed static planar hepatic blood pool images. All 21 patients with proven hepatic hemangiomas had a positive SPECT exam and 17 of the 21 (81%) patients had a positive planar exam. In the 21 patients, there were a total of 36 hemangiomas ranging in size from .7 cm to 13 cm. The SPECT imaging technique correctly identified all 36 lesions (100%) where as planar imaging detected 25 of the 36 lesions (69.4%). In all the remaining patients (10-normal, 17-metastatic disease, 12-hepatocellular disease, 6-hepatoma, 2-liver cysts), both the planar and SPECT imaging techniques were interpreted as showing no evidence of focal sequestration of red blood cells. SPECT hepatic blood pool imaging represents an improvement in the evaluation of hepatic hemangioma as a result of a reduction in imaging time (less than thirty minutes), improved spatial resolution and greater overall accuracy.

  12. A rapidly enlarging cutaneous hemangioma in pregnancy.

    LENUS (Irish Health Repository)

    Ma'ayeh, Marwan

    2014-06-18

    This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient\\'s thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor.

  13. Cardiac hemangioma presenting with angina pectoris.

    Science.gov (United States)

    Rajab, Taufiek K; Khalpey, Zain; Cohn, Lawrence H; Gallegos, Robert P

    2010-11-01

    A 60-year-old female presented with a two-year history of exertional chest pain and progressive dyspnea. Resection of a cardiac hemangioma arising from the area of the bifurcation of the left anterior descending and circumflex coronary arteries resulted in complete resolution of her symptoms. The symptoms were likely caused by coronary steal. © 2010 Wiley Periodicals, Inc.

  14. Adult Kasabach-Merritt Syndrome due to Hepatic Giant Hemangioma

    OpenAIRE

    Ahmet Aslan; Andreas Meyer zu Vilsendorf; Moritz Kleine; Martin Bredt; Hüseyin Bektas

    2009-01-01

    Cavernous hemangiomas are the most common benign tumors of the liver. They can reach enormous sizes and cause various complications. Kasabach-Merritt syndrome is a rare but serious complication characterized by consumptive coagulopathy caused by the hemangioma; mortality rate ranges between 10 and 37%. More than 80% of cases occur within the first year of life. Goals of the treatment are to control the coagulopathyand thrombocytopenia as well as to eradicate the hemangioma. Different nonsurgi...

  15. Transcatheter Arterial Embolization Alone for Giant Hepatic Hemangioma

    OpenAIRE

    Jun-Hui Sun; Chun-Hui Nie; Yue-Lin Zhang; Guan-Hui Zhou; Jing Ai; Tan-Yang Zhou; Tong-Yin Zhu; Ai-Bin Zhang; Wei-Lin Wang; Shu-Sen Zheng

    2015-01-01

    Giant hepatic hemangioma is a benign liver condition that may be treated using surgery. We studied the digital subtraction angiographic (DSA) characteristics of giant hepatic hemangioma, and the effectiveness of transcatheter arterial embolization (TAE) alone for its treatment. This was a retrospective study of 27 patients diagnosed with giant hepatic hemangioma and treated with TAE alone (using lipiodol mixed with pingyangmycin) at the Division of Hepatobiliary and Pancreatic Surgery, First ...

  16. Atypically enhanced cavernous hemangiomas of the liver: centrifugal enhancement does not preclude the diagnosis of hepatic hemangioma.

    Science.gov (United States)

    Matsushita, Masahiro; Takehara, Yasuo; Nasu, Hatsuko; Hirai, Yuki; Yamashita, Shuhei; Souda, Kenichi; Kobayashi, Yoshimasa; Miura, Katsutoshi

    2006-12-01

    The imaging features of an atypically enhanced hepatic hemangioma have not been well described in the literature, and the presence of such atypia may sometimes cause clinical problems in the differential diagnosis. Herein, we report a case of hepatic hemangioma demonstrating a previously unreported atypical enhancement pattern. On dynamic computed tomography during hepatic arteriography, a centrifugal enhancement pattern and subsequent peritumoral ring-shaped enhancement mimicking corona enhancement were found in cavernous hemangiomas of the liver in a 68-year-old Japanese man. Histopathological diagnosis of cavernous hemangioma of the liver was made on a biopsy specimen. Considering the importance of differentiating benign hepatic tumor from various forms of malignancy, radiologists and hepatologists should be aware of rare enhancement patterns sometimes seen in hepatic hemangioma. Establishing knowledge of the entire spectrum of atypical hepatic hemangioma may benefit the rational approach to future cases.

  17. Conversion of a neonatal hepatic hemangioma to focal nodular hyperplasia.

    Science.gov (United States)

    Turowski, Carmen; Feist, Henning; Alzen, Gerhard; Glüer, Sylvia; Petersen, Claus

    2009-04-01

    Hepatic hemangioma and focal nodular hyperplasia are both frequently observed benign lesions of the liver. Whereas hepatic hemangioma is the most frequent benign liver tumor in children, focal nodular hyperplasia occurs predominantly in adult patients. Concomitance of both entities has been described in adults, suggesting a similar pathogenesis. We report on a 6-month-old child with a continuously shrinking hepatic hemangioma after interventional therapy and a growing hepatic mass 5 years later, which emerged as focal nodular hyperplasia at the site of the former hemangioma. Diagnostic and therapeutic strategies regarding this patient are discussed. The present case supports the theory that these two entities may share a similar pathomechanism.

  18. Central hemangioma of mandible presenting as massive radiolucency

    Directory of Open Access Journals (Sweden)

    Simi Thankappan

    2009-01-01

    Full Text Available A hemangioma is a proliferation of blood vessels that creates a mass resembling a neoplasm. Some regard it as a true neoplasm while others state that it is a hamartoma resulting from proliferation of mesodermal cells that undergo endothelial differentiation and subsequently are canalized and vascularized. A central hemangioma rarely develops in the jaws. This case report deals with a low flow hemangioma in the ramus of the mandible, which despite its large size proved to be innocuous and lacked most of the characteristics of a conventional central hemangioma.

  19. Pedunculated Hepatic Hemangioma - A case report

    Directory of Open Access Journals (Sweden)

    Mostafa Elhajjam

    2014-06-01

    Full Text Available Pedunculated hemangioma is a rare and atypical hepatic angioma. We report the case of a pedunculated hepatic hemangioma presenting as an abdominal sub-hepatic mass incidentally discovered in a 66-year-old woman with anal cancer. The diagnosis was strongly suggested by the vascular features of the lesion on spiral computed tomography (CT and magnetic resonance (MR imaging. A surgical removal of the mass was decided to prevent potential risk of ischemic volvulus along the pedicle. Histo-pathological examination confirmed this diagnosis. Contrast enhanced thin sections and subsequent multiplanar reconstructions on CT and MR are very helpful to show the angioma features and the pedicle linking the lesion with the liver.

  20. Surgical treatment of painful hepatic hemangioma

    Directory of Open Access Journals (Sweden)

    Sergio Renato Pais Costa

    2009-03-01

    Full Text Available Hemangiomas are the  most common hepatic benign lesions. They occur most frequently in young female patients. These tumors are generally found by  radiological imaging and, of such examinations, nuclear magnetic resonance is the best diagnostic method. Although highly frequent, it presents few symptoms. Most  cases are asymptomatic and thus must be followed up by means of periodic radiological examination. Surgical treatment should be restricted to unusual situations. Spontaneous or traumatic rupture, Kasabach-Merritt syndrome, uncertain diagnosis and pain have been the most common indications. The authors describe a successfully treated  case of painful hemangioma of the left hepatic lobe submitted to left hepatectomy.

  1. Update on the classification of hemangioma.

    Science.gov (United States)

    George, Antony; Mani, Varghese; Noufal, Ahammed

    2014-09-01

    Despite the fact that a biological classification of congenital vascular tumors and malformations was first published in 1982 by Mulliken and Glowacki, significant confusion still prevails due to the indiscriminate and interchangeable use of the terms hemangioma and vascular malformation. Hemangiomas are true neoplasms of endothelial cells and should be differentiated from vascular malformations which are localized defects of vascular morphogenesis. On an analysis of various scientific articles and latest edition of medical text books an inappropriate use of various terms for vascular lesions was found, contributing further towards the confusion. The widely accepted International Society for the Study of Vascular Anomalies (ISSVA) classification differentiates lesions with proliferative endothelium from lesions with structural anomalies and has been very helpful in standardizing the terminologies. In addition to overcoming obstacles in communication when describing a vascular lesion, it is important that we adhere to the correct terminology, as the therapeutic guidelines, management and follow-up of these lesions differ.

  2. A Giant Hemangioma of the Tongue

    Directory of Open Access Journals (Sweden)

    Babak Saedi

    2011-01-01

    Full Text Available Introduction: Vascular abnormalities are relatively uncommon lesions, but head and neck is a common region for vascular malformation which is classified as benign tumors. In this paper, the authors report a rare presentation of vascular malformation in the tongue and its managements. Case Report: An 18 months 2 old child presented with a giant mass of tongue which caused functional and aesthetic problem. The rapid growth pattern of cavernous hemangioma was refractory to corticosteroid. The lesion was excised without any complication. Since the mass was so huge that not only filled entire oral cavity but was protruding outside, airway management was a great challenge for anesthesia plan and at the same time surgical technique was difficult to select. Conclusion: Despite different recommended modalities in managing hemangiomas of the tongue, in cases of huge malformations, surgery could be the mainstay treatment and provided that critical care measures are taken in to account, could be performed very safely.

  3. Hemangioma hepático gigante roto Giant hepatic hemangioma with spontaneous rupture

    Directory of Open Access Journals (Sweden)

    Paulo Cezar Galvão do Amaral

    2009-06-01

    Full Text Available INTRODUÇÃO: Ruptura por hemangioma hepático é rara e há somente 32 casos descritos na literatura. RELATO DO CASO: Homem com 39 anos foi admitido com dor abdominal em hipocôndrio direito de início súbito associado à lipotímia. A investigação inicial demonstrou hemangioma hepático gigante (7x13 cm em lobo direito associado a sinais de sangramento recente. Com o intuito de minimizar possibilidade de sangramento no intra-operatório, foi realizado embolização da artéria hepática direita. A operação transcorreu sem intercorrências, sem necessidade de hemotransfusão no intra-operatório. A transecção foi realizada com grampeador linear cortante de 75 mm. O tempo de internação foi de 13 dias. CONCLUSÃO: Procedimento cirúrgico é mandatório para hemangioma hepático roto, e a embolização é eficiente para controlar o sangramento e preparar melhor o paciente para a operação.BACKGROUND: Hepatic hemangioma rupture is rare and there are only 32 cases in the literature. CASE REPORT: A 39-years-old man was admitted for sudden severe upper abdominal pain. Examination revealed a giant liver hemangioma (7x13 cm in right lobe of the liver with signals of recent bleeding. Large feeding artery was embolised to reduce bleeding risk. The surgery occurred without transfusion. The liver trans-section was done with 75 mm linear stapler. The patient was discharged in the 13th post-operative day. CONCLUSION: Surgery is mandatory in hepatic hemangioma rupture and embolization is efficient in controlling pre-operative bleeding giving better opportunity to successful surgical procedure.

  4. Dural cavernous hemangioma of the cerebellar falx.

    Science.gov (United States)

    Ito, Masaki; Kamiyama, Hiroyasu; Nakamura, Takatoshi; Nakajima, Hideki; Tokugawa, Joji

    2009-09-01

    A 47-year-old man presented with a rare case of dural cavernous hemangioma of the cerebellar falx incidentally detected as a mass lesion in the posterior cranial fossa. Neurological examination revealed no deficits or physical symptoms. Computed tomography demonstrated a well-demarcated hyperdense mass, with no calcification, in the cerebellar vallecula. Magnetic resonance imaging showed the extra-axial mass as homogeneously isointense on T(1)-weighted images, and hyperintense on T(2)-weighted images, compared to the adjacent cerebellar parenchyma that had no hypointense halo. The cerebellar vermis was slightly compressed ventrally, the adjacent brain parenchyma was not swollen, and there was no evidence of hydrocephalus. The mass and the attached cerebellar falx were homogeneously enhanced by contrast medium. The dural enhancement was considered a dural tail. No other intracranial vascular malformations were found. The preoperative diagnosis was posterior cranial fossa meningioma attached to the cerebellar falx. Median suboccipital craniotomy exposed the reddish mass attached to the cerebellar falx. The arachnoid plane was well preserved. Total en bloc resection was performed with minimal blood loss. The postoperative course was unremarkable. The resected mass had a reddish-brown mulberry appearance, with spongy cross section with multiple blood-filled spaces. Histological examination identified dilated blood-containing channels lined with flattened endothelium and separated by fibrous tissue, but no luminal thrombus or hemorrhage. The histological diagnosis was dural cavernous hemangioma of the cerebellar falx. Preoperative radiosurgery or embolization is recommended for most of the dural cavernous hemangiomas, but surgery for the present dural cavernous hemangioma of the cerebellar falx was performed safely.

  5. Modalidades de tratamiento para el hemangioma coroideo circunscrito Therapeutic modalities for circumscribed choroidal hemangioma

    OpenAIRE

    Caridad Chiang Rodríguez; Yusimik Toledo González; Raúl Rúa Martínez; Maritza Pérez Pérez

    2010-01-01

    El manejo del hemangioma coroideo circunscrito se relaciona con la presencia de síntomas; en casos asintomáticos es suficiente la simple observación. El objetivo del tratamiento es la conservación o mejora de la agudeza visual, produciendo la reabsorción del líquido subretiniano y la resolución del edema macular. El hemangioma coroideo es una tumoración vascular de coroides que se puede presentar como forma circunscrita y sin conexión sistémica o bien de forma difusa generalmente asociada a e...

  6. Diffuse Cavernous Hemangioma of the Colon.

    Science.gov (United States)

    Mirioglu, S; Cavus, B; Iliaz, R; Besisik, F

    2016-01-01

    A 70-year-old man was admitted to our clinic with a history of rectal bleeding and constipation, his colonoscopy revealed varicosities and bluish nodular lesions of the rectum (Figure 1). Abdominal CT showed multiple nodular lesions beginning from the distal descending colon and extending to the rectum, calcifications suggesting phleboliths were also seen in these lesions. A contrast enhanced pelvic MRI demonstrated multiple tubular lesions showing hyperintensity on T2-weighted images and hypointensity on T1-weighted images, consistent with the affected areas on the CT scan (Figure 2). It was a diffuse cavernous hemangioma, which mostly affects the rectosigmoid colon in the gastrointestinal tract, and can clinically mimic internal hemorrhoids, ulcerative colitis or cancer (1). Gastrointestinal hemangioma is a rare benign vascular neoplasm, and might be associated with a congenital disorder like Osler-Weber-Rendu disease, Maffucci's syndrome, Klippel-Trénaunay syndrome, or the congenital blue rubber bleb nevus syndrome (2). Even though there are different medical treatment options targeting VEGF and FGF-mediated pathways such as bevacizumab and thalidomide, and endoscopic approaches like sclerotherapy and electrocautery; complete resection of the hemangioma is the only curative treatment method (1, 3). Therefore, the patient was referred to department of surgery for a definitive treatment, and lost to follow-up.

  7. Cytogenetic study of a pulmonary sclerosing hemangioma.

    Science.gov (United States)

    Pareja, María J; Vargas, María T; Sánchez, Ana; Ibáñez, José; González-Cámpora, Ricardo

    2009-11-01

    Pulmonary sclerosing hemangioma (PSH) is an uncommon benign tumor that presents as a solitary asymptomatic and slow-growing nodule. It occurs in both young and old persons; peak incidence is in the fifth decade. Both sexes are affected by this tumor, but women more frequently than men. On histological examination, PSH shows prominent sclerotization and vascularization of the tissue. Recent studies conclude that PSH derives from type II pneumocytes, but the potential for progression and histogenesis remains controversial. We report a case of pulmonary sclerosing hemangioma in a 61-year-old woman with a neoplastic node 1 cm in diameter. The karyotype was 46,XX,t(8;18),der(14;15),+14 in all the cells analyzed. PTEN (10q23) and IgH (14q32) probes were analyzed in interphase nuclei and paraffin-embedded tissues of tumor cells. These chromosome abnormalities could provide information about the relationship of genetic changes to the biological properties of sclerosing hemangioma tumors.

  8. [Giant hepatic hemangioma associated with Kasabach-Merrit syndrome].

    Science.gov (United States)

    Valdés Mas, M; Ortiz Sánchez, M L; Rodrigo Agudo, J L; Miras López, M; Pons Miñano, J A; Carballo Alvarez, F

    2008-08-01

    Hepatic hemangioma is the most frequent liver's tumor. The majority are small, asymptomatic and have an excellent prognosis. Those larger than 5 cm can be associated to a consumptive coagulopathy called Kasabach-Merrit syndrome. We present a patient with a giant hepatic hemangioma with multiple hemangimatosis associated to Kasabach-Merrit syndrome.

  9. Urethral hemangioma: case report and review of the literature ...

    African Journals Online (AJOL)

    ... from the terminal urethra (urethral hemangioma). We performed surgical resection of the tumor, along with bladder drainage. The postoperative course was simple. We update through a review of the literature aspects of the diagnostic and therapeutic care of the urethral hemangioma. Pan African Medical Journal 2016; 23 ...

  10. Calcified cavernous hemangioma of the ovary: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yeon Hee [Dankook Univ. College of Medicine, Seoul (Korea, Republic of)

    2000-12-01

    Ovarian hemangiomas are very uncommon and most are of the cavernous type. A few reports have described the radiologic findings of this neoplasm, but as far as the author is aware, the literature contains no description of calcified cavernous hemangioma. A case in which this condition involved the ovary is now reported.

  11. Verrucous lymphovascular malformation versus verrucous hemangioma: controversial nomenclature.

    Science.gov (United States)

    Brown, Allison; Warren, Simon; Losken, H Wolfgang; Morrell, Dean S

    2008-05-01

    The International Society for the Study of Vascular Anomalies (ISSVA) divides congenital vascular anomalies into malformations and tumors and subclassified hemangiomas under tumors. However, evidence shows this accepted classification has not been widely employed. Particularly troublesome is the use of the term hemangioma, commonly used to describe a variety of vascular lesions (both malformations and tumors). The term verrucous hemangioma has been used to describe a congenital vascular anomaly with a progressive verrucous epidermal surface persisting throughout life unless surgically excised. Recent evidence suggests that some of these lesions may share histologic features of both hemangiomas and malformations, thereby causing nosologic confusion. We report a 15-year-old adolescent girl with such a lesion and review the literature and controversy of verrucous hemangiomas. In our case, the most appropriate diagnosis is verrucous lymphovascular malformation. Further testing of similar lesions will be necessary to fully understand the nature and classification of these lesions.

  12. Vesical hemangioma in patient with Klippel-Trenaunay-Weber syndrome

    Directory of Open Access Journals (Sweden)

    Favorito Luciano A.

    2003-01-01

    Full Text Available Klippel-Trenaunay-Weber syndrome is characterized by cutaneous hemangiomas, varicosity and bony hypertrophy of extremities. Urinary tract hemangiomas may occur in 3 to 6% of these patients. This work intends to report a case of a patient with a huge vesical hemangioma, who presented this syndrome. A 5 year-old boy with Klippel syndrome sought our services due to 3 episodes of gross hematuria in the past 30 days. Excretory urography and computerized tomography were performed, indicating the presence of a swelling in vesical dome. An exploratory cystotomy was conducted and the dark colored mass in vesical dome was excised by partial cystectomy. The histopathologic finding confirmed that it was a vesical hemangioma. Though rare, urinary tract hemangiomas must always be considered in patients with Klippel-Trenaunay syndrome.

  13. Cavernous hemangioma of the posterior mediastinum with bony invasion.

    Science.gov (United States)

    Yun, Takamasa; Suzuki, Hidemi; Tagawa, Tetsuzo; Iwata, Takekazu; Mizobuchi, Teruaki; Yoshida, Shigetoshi; Yamazaki, Masashi; Yoshino, Ichiro

    2016-01-01

    We herein report a case of a cavernous hemangioma of the posterior mediastinum treated with surgical resection. Mediastinal hemangiomas are rare and diagnosis is difficult prior to operation. A 58-year-old female was referred to our hospital for back pain and a tumor in the left posterior mediastinum that was detected by chest computed tomography (CT). CT showed a tumor adjacent to the left side of the fifth thoracic vertebrae measuring 60 × 50 mm with invasion into and destruction of the 5th rib. The tumor was resected successfully via hemilaminectomy with costotransversectomy, and was revealed to be a cavernous hemangioma histologically. 1 year and 5 months after surgery, the patient was asymptomatic and without a recurrence. Hemangiomas are usually considered benign but sometimes behave aggressively with destruction of the neighboring structures. We consider en bloc resection to be safe and effective for aggressive cavernous hemangiomas of the posterior mediastinum.

  14. Successful liver resection in a giant hemangioma with intestinal obstruction after embolization

    OpenAIRE

    Zhou, Ji-Xiang; Huang, Ji-Wei; Wu, Hong; Zeng, Yong

    2013-01-01

    Hepatic hemangiomas are the most common benign tumor of the liver. Most hepatic hemangiomas remain asymptomatic and require no treatment. Giant hepatic hemangiomas with established complications, diagnostic uncertainty and incapacitating symptoms, however, are generally considered an absolute indication for surgical resection. We present a case of a giant hemangioma with intestinal obstruction following transcatheter arterial embolization, by which the volume of the hemangioma was significant...

  15. Giant hepatic hemangioma versus conventional hepatic hemangioma: Clinical findings, risk factors, and management

    Directory of Open Access Journals (Sweden)

    C. Moctezuma-Velázquez

    2014-10-01

    Conclusions: GHHs are more prevalent in women and when symptomatic, pain is the most frequent complaint. Diagnosis is usually made through imaging studies, but when there is diagnostic doubt, surgical exploration is sometimes needed. Oral contraceptive use is most likely more of a risk factor for GHH than for conventional hemangioma, but this association needs to be studied further.

  16. A symptomatic giant hepatic hemangioma treated with hepatectomy.

    Science.gov (United States)

    Uetama, Toshifumi; Yoshida, Hiroshi; Hirakata, Atsushi; Yokoyama, Tadashi; Maruyama, Hiroshi; Suzuki, Seiji; Matsutani, Takeshi; Matsushita, Akira; Sasajima, Koji; Uchida, Eiji

    2011-01-01

    We describe a patient with symptomatic giant hepatic hemangioma treated with hepatectomy. A 53-year-old woman presented with upper abdominal distension and appetite loss. The medical history included multiple hepatic hemangiomas that had been detected 2 years earlier but were left untreated. Initial laboratory tests revealed pancytopenia and mild coagulopathy. Computed tomography and magnetic resonance imaging demonstrated a giant hemangioma, 27 cm in diameter, in the enlarged right lobe of the liver. The inferior vena cava was compressed by tumor without thrombus in the infrahepatic vena cava. The portal venous phase of supramesenteric arteriography revealed compression of the portal vein. There were several hemangiomas in the left lobe. Gastric outlet obstruction due to giant hepatic hemangioma in the right lobe was diagnosed. Laparotomy was performed, and a markedly enlarged liver was detected. Right hepatectomy was performed with an anterior approach. The liver-hanging maneuver could not be performed because of tumor compression of the inferior vena cava. Right hepatectomy was performed with intermittent clamping (Pringle maneuver). Hepatic hemangiomas of the left lobe were not resected because the remnant liver would be reduced. The weight of the resected specimen was 2,100 g. Pathologic examination of the surgical specimen confirmed the presence of benign hepatic hemangiomas. The postoperative course was uneventful, and the patient's appetite improved. The patient was discharged 8 days after the operation. Abdominal distension decreased and laboratory data improved after the operation. Computed tomography revealed hypertrophy of the left lobe of the liver after the operation.

  17. Hemangioma intramuscular de la infancia simulando rabdomiosarcoma

    OpenAIRE

    Panisello Sebastiá, Juan José; Martínez Martín, Angel Antonio; Domingo Cebollada, Luis Javier; Alvarez Alegret, Ramiro; Martínez Tello, Ana Mª

    1998-01-01

    Se presenta un caso de hemangioma intramuscular de la infancia en una paciente de 14 meses de edad en quien la historia, examen clínico y técnicas de imagen sugerían un rabdomiosarcoma. El tratamiento plateado fue la escisión en bloque, y la anatomía patológica reveló la verdadera naturaleza de la lesión. Se revisan las características de este raro tumor y los elementos que lo hacen semejante a lesiones malignas. We report a case of intramuscular haemangioma occurring in a 14-month-old gir...

  18. Role of histochemical stains in differentiating hemangioma and vascular malformation

    Directory of Open Access Journals (Sweden)

    Ruchir Jitendra Patel

    2016-01-01

    Full Text Available Background: Benign vascular lesions such as vascular malformation and hemangioma at times pose difficulty in diagnosis both for clinicians and pathologists. Vascular malformations are difficult to treat while hemangiomas resolve spontaneously in most instances. There are instances when vascular malformations, especially arteriovenous malformations (AVMs have been misdiagnosed as hemangiomas and vice-versa. Clinical and radiological correlation with histopathological confirmation of these anomalies is important for the management of these lesionsAim: The aim was to study the histological characteristics of hemangiomas and vascular malformations and to study the utility of histochemical stains in their diagnosis. Materials and Methods: We retrospectively studied fifty cases retrieved from the records of Department of Pathology which were diagnosed as hemangioma (n=32 and vascular malformation (n=18 on Hematoxylin and Eosin (H and E stain over a period of 18 months. The cases were analyzed based on findings of histochemical stains such as Verhoeff-van Gieson (VVG, Masson's trichrome (MT, and toluidine blue. Results: After reviewing all the cases with the use of histochemical stains, two of the three cases originally diagnosed as hemangioma turned out to be AVM and one to be venous malformation. An increased number of intra-lesional nerves were found in 16 of 19 cases of AVM and in both cases of venous and lymphatic malformation. Hemangiomas did not show increase in nerve bundles. Mast cells were found to be increased in proliferating hemangiomas and pyogenic granulomas as compared to AVMs. Conclusion: Hemangiomas and vascular malformations should be clearly differentiated to reduce the risk of treatment failure and recurrence. With the use of histochemical stains such as VVG, MT and toluidine blue, the diagnostic difficulty can be reduced and definitive diagnosis is possible.

  19. An unusual cause of acute pulmonary embolism: giant hepatic hemangioma

    Directory of Open Access Journals (Sweden)

    Hatice Duygu Hatice Duygu Bas

    2016-06-01

    Full Text Available Hemangiomas are the most common benign hepatic tumors and are usually asymptomatic. Lesions measuring more than 4 cm in diameter are known as “giant hemangiomas” and may cause various symptoms or complications depending on the size, the location, and the degree of compression of adjacent structures. Pulmonary embolism is a very rare complication of giant hepatic hemangiomas. In this case report, we describe a patient with acute pulmonary emboli, which presumably originated from laminar thrombi in the inferior vena cava caused by compression by giant hepatic hemangiomas.

  20. Management of infantile asthma.

    Science.gov (United States)

    Brasher, G W

    1977-09-01

    Infantile asthama is an important pediatric problem and may cause substantial morbidity and mortality in this age group. The pathophysiology of allergic asthma involves a type I hypersensitivity reaction that is mediated by reaginic antibodies of the IgE class. Various factors predisposing to infantile asthma have been suggested but not confirmed. The differential diagnosis of infantile wheezing is of particular importance in this very young age group. An appreciation of the natural history and clinical characteristics of the disease, and of the important causative factors (foods, environmental inhalants, and respiratory infections), will aid the physician in the management of this problem.

  1. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation.

    Science.gov (United States)

    Munabi, Naikhoba C O; England, Ryan W; Edwards, Andrew K; Kitajewski, Alison A; Tan, Qian Kun; Weinstein, Andrew; Kung, Justin E; Wilcox, Maya; Kitajewski, Jan K; Shawber, Carrie J; Wu, June K

    2016-01-01

    Infantile hemangiomas (IHs) are the most common vascular tumor and arise from a hemangioma stem cell (HemSC). Propranolol has proved efficacious for problematic IHs. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist that can lower cAMP levels and activate the mitogen-activated protein kinase (MAPK) pathway downstream of βARs. We found that HemSCs express β1AR and β2AR in proliferating IHs and determined the role of these βARs and the downstream pathways in mediating propranolol's effects. In isolated HemSCs, propranolol suppressed cAMP levels and activated extracellular signal-regulated kinase (ERK)1/2 in a dose-dependent fashion. Propranolol, used at doses of Propranolol at ≥10(-5) M reduced cAMP levels and activated ERK1/2, and this correlated with HemSC apoptosis and cytotoxicity at ≥10(-4) M. Stimulation with a βAR agonist, isoprenaline, promoted HemSC proliferation and rescued the antiproliferative effects of propranolol, suggesting that propranolol inhibits βAR signaling in HemSCs. Treatment with a cAMP analog or a MAPK inhibitor partially rescued the HemSC cell viability suppressed by propranolol. A selective β2AR antagonist mirrored propranolol's effects on HemSCs in a dose-dependent fashion, and a selective β1AR antagonist had no effect, supporting a role for β2AR signaling in IH pathobiology. In a mouse model of IH, propranolol reduced the vessel caliber and blood flow assessed by ultrasound Doppler and increased activation of ERK1/2 in IH cells. We have thus demonstrated that propranolol acts on HemSCs in IH to suppress proliferation and promote apoptosis in a dose-dependent fashion via β2AR perturbation, resulting in reduced cAMP and MAPK activation. The present study investigated the action of propranolol in infantile hemangiomas (IHs). IHs are the most common vascular tumor in children and have been proposed to arise from a hemangioma stem cell (HemSC). Propranolol, a nonselective β-adrenergic receptor (

  2. Hemangiomas de la infancia, manejo actual

    Directory of Open Access Journals (Sweden)

    H. M. Carolina Lobos, Dra.

    2011-11-01

    Full Text Available Durante años se ha usado una nomenclatura imprecisa para designar a las “Anomalías Vasculares de la Infancia”. Esto ha contribuido a diagnósticos erróneos y como consecuencia, a tratamientos inadecuados. La clasificación actual las separa en dos grandes grupos: las malformaciones vasculares y un gran grupo de tumores vasculares, que incluyen principalmente a los clásicos hemangiomas de la infancia y a “nuevos tumores vasculares” que tienen una evolución distinta. Recientemente nuevos hallazgos asociados a las anomalías vasculares de la infancia ha obligado a establecer cambios en el diagnóstico y manejo de estas lesiones con un fuerte énfasis en el manejo multidisciplinario. En el presente artículo se analizan los hemangiomas de la infancia con sus características clínicas, asociaciones con otras patologías y evolución. Se plantean alternativas de estudio y tratamiento.

  3. Recurrent hepatic hemangiomas. Possible association with estrogen therapy.

    Science.gov (United States)

    Conter, R L; Longmire, W P

    1988-01-01

    Hemangiomas are the most common benign tumors occurring in the liver. However, the natural history of hepatic hemangiomas has not been well defined. Four patients (3 women, 1 man) with recurrent giant liver hemangiomas underwent either surgical or radiation therapy as initial treatment for the primary tumor. The average time until recurrence was 14 years, and each tumor weighed more than 600 g. Each of the female patients had been given chronic estrogen (Premarin) replacement therapy. Three of the four patients underwent surgical resection for intractable symptoms or progressive enlargement. It is believed that estrogen replacement therapy may play a role in the pathogenesis of these tumors. Furthermore, operative intervention should be considered in patients with recurrent giant liver hemangioma. Images Fig. 1. Fig. 2. Fig. 3. Fig. 4. Figs. 5A-C. Figs. 5A-C. PMID:2829759

  4. Ruptured giant hepatic hemangioma: report of a case.

    Science.gov (United States)

    Jangjoo, Ali; Mehrabi Bahar, Mostafa; Aliakbarian, Mohsen

    2010-01-01

    Hemangiomas are the most common benign liver masses with a frequency of 0.4-7.3% at autopsy. They are usually discovered incidentally and a few require surgery. Spontaneous or traumatic ruptures are among indications of surgery for hemangiomas. We report a case of giant hepatic hemangioma presenting as hemoperitoneum following use of the slimming belt that underwent an emergent laparotomy. Abdominal exploration revealed that both right and left lobes of the liver were involved with giant hemangiomas. The liver was compressed by tightly packing laparotomy pads. After the operation, the patient was admitted to the surgical intensive care unit. Two days later, a second surgery was performed to remove the laparotomy pads. On the 6th day, the patient was discharged. One month later, to shrink the tumor, percutaneous transarterial embolization of the hepatic artery was performed.

  5. Hepatic hemangioma masquerading as a tumor originating from the stomach.

    Science.gov (United States)

    Zhang, Xingmao; Zhou, Zhixiang

    2015-03-01

    Hemangioma is the most common benign hepatic neoplasm. The majority of cases are asymptomatic and can be confirmed by imaging examinations, including enhanced computed tomography and magnetic resonance imaging. Exophytic growth is not common and pedunculated cases are extremely rare. The present study reports a case that was pre-operatively misdiagnosed as a stomach-originating tumor. Laparoscopic exploration confirmed that this tumor was a hepatic hemangioma with a long peduncle originating from the left edge of the liver. The final diagnosis of cavernous hemangioma was confirmed by postoperative pathology. This indicates that hepatic hemangioma with a long peduncle has the possibility to be inaccurately diagnosed. Laparoscopic examination is required for such cases.

  6. Adult Kasabach-Merritt Syndrome due to Hepatic Giant Hemangioma

    Directory of Open Access Journals (Sweden)

    Ahmet Aslan

    2009-11-01

    Full Text Available Cavernous hemangiomas are the most common benign tumors of the liver. They can reach enormous sizes and cause various complications. Kasabach-Merritt syndrome is a rare but serious complication characterized by consumptive coagulopathy caused by the hemangioma; mortality rate ranges between 10 and 37%. More than 80% of cases occur within the first year of life. Goals of the treatment are to control the coagulopathyand thrombocytopenia as well as to eradicate the hemangioma. Different nonsurgical treatment regimens are performed, includingsystemic corticosteroids, irradiation and various chemicals. Surgery should be limited to symptomatic or complicated cases. Although difficult, resection of the tumor is usually curative. Here we present a 44-year-old woman with giant hepatic hemangioma causing Kasabach-Merritt syndrome managed by enucleation.

  7. Antenatal diagnosis of congenital hepatic hemangioma: a case report.

    Science.gov (United States)

    Cabrita, Sofia Vargas; Gonçalves, Sónia; Rodrigues, Henrique; Guerra, Nuno; Moura, Paulo

    2009-08-07

    Hepatic tumors in children account for only 1 to 5% of all pediatric tumors. Hepatic hemangioma is, however, the third most common tumor of the liver in childhood. We report a case of an antenatal diagnosis of a hepatic tumor detected on a first obstetric ultrasound, at 26(th) week of gestation. It revealed a complex, predominantly solid hepatic lesion with 3 x 3 cm and a marked, essentially peripheral, Doppler blood flow. Fetal echocardiography showed a normal heart besides a vena cava displacement by the hepatic mass. Fetal Hepatic hemangioma was suspected. Follow-up ultrasounds were unchanged. Pregnancy evolved well. At 36 weeks of gestation was spontaneously delivered a 3300 g boy whose examination revealed a visible thoracoabdominal circulation and a palpable liver. No skin lesions, namely hemangiomas or petechiae were identified. Postnatal magnetic resonance imaging confirmed the diagnosis of Hepatic hemangioma. Treatment was initiated with prednisolone followed by interferon. After 2 years, there is no active lesion.

  8. Hemorrhagic hemangioma in the liver: A case report

    Science.gov (United States)

    Kim, Jeong Min; Chung, Woo Jin; Jang, Byoung Kuk; Hwang, Jae Seok; Kim, Yong Hoon; Kwon, Jung Hyeok; Choi, Mi Sun

    2015-01-01

    Hemangioma is the most common type of benign tumor that arises in the liver. Although rupture and hemorrhage of hepatic hemangioma are rare complications, they can be the cause of mortality. The authors report a case of hemorrhagic hepatic hemangioma: in a 54-year-old woman who was admitted with epigastric pain. She had taken oral contraceptives several weeks prior. The results of a blood examination were normal. An abdominal computed tomography scan revealed a tumor in hepatic segment 4, and a hemorrhage inside the cystic mass was suspected. The mass was removed laparoscopically to confirm the tumor properties and control the hemorrhage. The pathologic findings of the resected mass were consistent with hepatic hemangioma with intratumoral hemorrhage. The patient was discharged 8 d after the surgery, without further complications or complaints, and the patient’s condition was found to have improved during follow-up. PMID:26109822

  9. Ruptured Giant Hepatic Hemangioma: Report of A Case

    Directory of Open Access Journals (Sweden)

    Ali Jangjoo

    2010-12-01

    Full Text Available Hemangiomas are the most common benign liver masses with a frequency of 0.4-7.3% at autopsy. They are usually discovered incidentally and a few require surgery. Spontaneous or traumatic ruptures are among indications of surgery for hemangiomas. We report a case of giant hepatic hemangioma presenting as hemoperitoneum following use of the slimming belt that underwent an emergent laparotomy. Abdominal exploration revealed that both right and left lobes of the liver were involved with giant hemangiomas. The liver was compressed by tightly packing laparotomy pads. After the operation, the patient was admitted to the surgical intensive care unit. Two days later, a second surgery was performed to remove the laparotomy pads. On the 6th day, the patient was discharged. One month later, to shrink the tumor, percutaneous transarterial embolization of the hepatic artery was performed.

  10. Ruptured Giant Hepatic Hemangioma: Report of A Case

    Directory of Open Access Journals (Sweden)

    Ali Jangjoo

    2010-11-01

    Full Text Available "nHemangiomas are the most common benign liver masses with a frequency of 0.4-7.3% at autopsy. They are usually discovered incidentally and a few require surgery. Spontaneous or traumatic ruptures are among indications of surgery for hemangiomas. We report a case of giant hepatic hemangioma presenting as hemoperitoneum following use of the slimming belt that underwent an emergent laparotomy. Abdominal exploration revealed that both right and left lobes of the liver were involved with giant hemangiomas. The liver was compressed by tightly packing laparotomy pads. After the operation, the patient was admitted to the surgical intensive care unit. Two days later, a second surgery was performed to remove the laparotomy pads. On the 6th day, the patient was discharged. One month later, to shrink the tumor, percutaneous transarterial embolization of the hepatic artery was performed.

  11. Computed tomography of three cases of hepatic hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Shinichiro; Fukushima, Keisuke; Hino, Kazunari; Ohumi, Tsuneyo; Hirano, Yutaka (Kawasaki Medical School, Kurashiki, Okayama (Japan))

    1983-02-01

    The computed tomographic appearance of hepatic hemangioma was reported. Hepatic hemangioma appears as a well-defined, uniform low density area with mean CT No. of 32.7 H.U. CT No. of the lesions became isodense or more higher after contrast enhancement and the degree of enhancement was more than twice as high as the surrounding hepatic tissue. These findings seem to be useful in the differentiation from other focal lesions of the liver.

  12. Concomitant multiple cavernous hemangiomas and venous angioma of the orbit.

    Science.gov (United States)

    Wang, Xianggui; Yan, Jianhua

    2014-07-01

    The coexistence of multiple cavernous hemangiomas and venous malformation is an extremely rare clinical condition. In this report, we describe a patient showing initial multiple cavernous hemangiomas followed years later by a recurrence of multiple cavernous hemangiomas along with the appearance of venous angioma coexisting in the same orbit. A 52-year-old woman was referred with a gradually progressive proptosis and upward displacement of her left eye that were present for 10 years. The clinical features, computed tomography and ultrasonography examination, surgery, and histopathologic findings from this patient with multiple cavernous hemangiomas coexisting with venous angioma in the same orbit are presented. Color Doppler ultrasonography and computed tomography scan displayed more than 10 well-defined homogenous masses in the left orbit measuring 0.5 × 0.5 to 1.0 × 0.8 cm with no blood flow. Anterior orbitotomy of the left eye was performed. Fifteen accessible, distinct, red-purple, round masses were excised with tumors measuring 0.5 × 0.5 × 0.6 to 1.0 × 1.0 × 1.0 cm. Histopathologic analysis confirmed the diagnosis of multiple cavernous hemangiomas. Eight years later, she again developed left proptosis. Color Doppler ultrasonography and computed tomography disclosed multiple smoothly outlined homogeneous masses in the left orbit ranging in size from 5 × 4 to 28 × 16 mm, along with some scattered, high-density, vein-stone shadows within the mass. An anterior orbitotomy was again performed. At surgery, 4 violaceous, well-defined, and cone-shaped masses were removed with minimal bleeding. Histopathologic examination confirmed the diagnosis of multiple cavernous hemangiomas with coexisting venous angioma. There was no recurrence of orbital hemangioma at 2 years after the second surgery. Orbital cavernous hemangioma and venous angioma may share a yet-to-be-described common link.

  13. Painful erections secondary to rare epithelioid hemangioma of the penis

    OpenAIRE

    Barber, Evan; Domes, Trustin

    2014-01-01

    Epithelioid hemangioma is a rare benign vascular tumour that atypically involves the penis and usually presents as a painful nodule. A 35-year-old man presented with a 5-month history of painful erections without a clinically apparent lesion or deformity. Magnetic resonance imaging (MRI) with pharmacologically induced erection demonstrated a 1.3-cm nodular lesion deep to the skin at the base of his penis. Following local excision of the lesion, which was diagnosed as an epithelioid hemangioma...

  14. Violencia y TV infantil

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    Valerio Fuenzalida

    2015-01-01

    Full Text Available Se establece tres razones para discrepar del “criterio reduccionista” que relaciona la violencia televisiva con la violencia real, particularmente en lo atinente a la televisión infantil. A base de las motivaciones infantiles para ver televisión, propone algunas líneas de acción que superen ese reduccionismo y optimicen la relación niños-televisión.

  15. Transcatheter Arterial Embolization Alone for Giant Hepatic Hemangioma.

    Science.gov (United States)

    Sun, Jun-Hui; Nie, Chun-Hui; Zhang, Yue-Lin; Zhou, Guan-Hui; Ai, Jing; Zhou, Tan-Yang; Zhu, Tong-Yin; Zhang, Ai-Bin; Wang, Wei-Lin; Zheng, Shu-Sen

    2015-01-01

    Giant hepatic hemangioma is a benign liver condition that may be treated using surgery. We studied the digital subtraction angiographic (DSA) characteristics of giant hepatic hemangioma, and the effectiveness of transcatheter arterial embolization (TAE) alone for its treatment. This was a retrospective study of 27 patients diagnosed with giant hepatic hemangioma and treated with TAE alone (using lipiodol mixed with pingyangmycin) at the Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, between January 2010 and March 2013. The feeding arteries were identified using DSA. All patients were followed up for between three weeks and 12 months. Changes in tumor diameter and symptoms were observed. The 27 patients included had giant hepatic hemangiomas ranging from 5.3 to 24.5 cm (mean, 11.24±5.08 cm) in the right (n = 13), left (n = 1) or both (n = 13) lobes. Preoperative hepatic angiography showed multiple abnormal vascular lakes in the early phase, known as the "early leaving but late returning, hanging nut on a twig" sign. On the day after TAE, hepatic transaminase levels were increased (ALT: 22.69±17.95 to 94.88±210.32 U/L; ALT: 24.00±12.37 to 99.70±211.54 U/L; both Phepatic hemangioma. TAE may be a useful alternative to surgery for the treatment of hepatic hemangioma.

  16. Hepatic hemangioma: findings of spiral CTHA and CTAP

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yun Hwan; Lee, Chang Hee; Suh, Won Hyuck [Korea Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-12-01

    To evaluate the characteristic finding of hepatic hemangioma on spiral CT during hepatic arteriography(CTHA) and arterial portography(CTAP). Twenty-eight hepatic hemangionas in ten patients were analyzed by spiral CTHA and CTAP, and were confirmed by US, conventional CT, MRI, and follow-up images. Their sizes varied between 5 and 6cm(average 1.8 cm); using CTHA and CTAP, enhancement patterns were analyzed according to size, and on CTHA were found to be homogeneous hyperattenuating(HH), peripheral globular hyperattenuating(PG), and mixed(M) type. All hepatic hemangiomas showed perfusion defects on CTAP. On CTHA, the PG type accounted for 16 of 28 hemangiomas(57%), the HH type for 7(25%), and the M type for 5(18%) ; CTHA also showed that 23 hemangiomas(82%) had an irregular enhanced margin. On CTHA, the most common characteristic finding of hepatic hemangioma was the peripheral globular enhancement pattern(57%). In the diagnosis of hepatic hemangioma accompanied by hepatocellular carcinoma or other liver metastasis, CTHA is more useful than CTAP ; in all cases the latter showed only perfusion defects.

  17. Infantile fibrosarcoma-a clinical and histologic mimicker of vascular malformations: case report and review of the literature.

    Science.gov (United States)

    Hu, Zhihong; Chou, Pauline M; Jennings, Lawrence J; Arva, Nicoleta C

    2013-01-01

    Infantile fibrosarcoma is a rare soft tissue tumor that usually presents either at birth or in the 1st year of life. Here we describe a case of a 4-month-old female who presented with a congenital right axillary mass. The initial clinical impression was benign vascular/lymphatic malformation. The core biopsy showed a spindle cell lesion with abundant vasculature represented by small vascular channels. However, immunohistochemical analysis did not support a diagnosis of vascular lesion/tumor. Polymerase chain reaction study for ETS Translocation Variant 6/neurotrophic tyrosine kinase receptor, type 3 fusion transcript was positive, and the diagnosis of infantile fibrosarcoma was established. The patient underwent resection of the axillary mass. Microscopic examination of the resection specimen showed numerous vascular channels. Intermixed there were also cellular areas composed of spindle cells similar to those seen in the biopsy material. Molecular studies were repeated and confirmed the diagnosis of infantile fibrosarcoma. Infantile fibrosarcoma has been previously reported in the literature to clinically masquerade as hemangioma. In addition, this case proves that infantile fibrosarcoma could also mimic vascular malformations on clinical, radiologic, and pathologic exams. In fact, the vascular component of the tumor is very unusual in our patient and represents a histologic feature that has not been described before. The case highlights the diagnostic challenges at clinical, radiologic, and pathologic levels in some cases of infantile fibrosarcoma and raises awareness among clinicians and pathologists related to another peculiar pattern that can be encountered in this disease.

  18. Modalidades de tratamiento para el hemangioma coroideo circunscrito Therapeutic modalities for circumscribed choroidal hemangioma

    Directory of Open Access Journals (Sweden)

    Caridad Chiang Rodríguez

    2010-01-01

    Full Text Available El manejo del hemangioma coroideo circunscrito se relaciona con la presencia de síntomas; en casos asintomáticos es suficiente la simple observación. El objetivo del tratamiento es la conservación o mejora de la agudeza visual, produciendo la reabsorción del líquido subretiniano y la resolución del edema macular. El hemangioma coroideo es una tumoración vascular de coroides que se puede presentar como forma circunscrita y sin conexión sistémica o bien de forma difusa generalmente asociada a enfermedades sistémicas. A pesar de su probable origen congénito, se suele diagnosticar de forma tardía entre la 2-5 décadas de la vida, si el tumor se asocia a desprendimiento de retina exudativo, apareciendo así los primeros síntomas. La incidencia del hemangioma circunscrito es difícil de establecer, pues muchos presentan un curso asintomático y no son diagnosticados; en relación con el melanoma de coroides su frecuencia es de 1/15. El manejo del hemangioma coroideo circunscrito se relaciona con la presencia de síntomas; en casos asintomáticos es suficiente la simple observación. El objetivo del tratamiento es la conservación ó mejora de la agudeza visual, produciendo la reabsorción del líquido subretiniano y la resolución del edema macular. Actualmente no existe un tratamiento específico por lo que hemos realizado una revisión de las diversas modalidades terapéuticas, sus ventajas y desventajas.The circumscribed choroidal hemangioma is a vascular tumor of the choroid that can be seen either in its circumscribed form without systemic connection or in its diffuse form, generally associated with systemic diseases. In spite of their likely congenital origin, it is usually diagnosed late when the patient is 20 to 50 years-old and if the tumor relates to exudative retinal detachment, thus emerging the first symptoms. The incidence of the circumscribed hemangioma is difficult to establish, because many patients are asymptomatic and

  19. Echogenic rim of hepatic hemangioma on abdominal ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sang Woo; Kang, Chang Ho; Kim, Jin Hyoung; Kim, Chul Joong; Cheong, In Joo; Kim, Baek Hyun; Cha, Sang Hoon; Park, Cheol Min; Chung, Kyu Byung [Korea University College of Medicine, Seoul (Korea, Republic of)

    2000-03-15

    To investigate the association between the size of the hepatic hemangioma and the shape and thickness of the echogenic rim of hepatic hemangioma on abdominal ultrasound. We examined 47 cases (M:F=24:23, mean age 47.1) of hepatic hemangiomas with echogenic rim on abdominal ultrasound during the past 2 years. Radiologic findings were retrospectively reviewed in terms of completeness and thickness of echogenic rim. If echogenic rim showed even thickness, it was measured. But if not, the maximum and minimum thickness of the rim was measured. The association between the size of hemangioma and the completeness and thickness of the echogenic rim were analyzed statistically. Of the 47 cases, complete echogenic rim and incomplete echogenic rim were obtained in 29 (62%) and 18 (38%) cases, respectively. Twenty-two cases of hemangioma were less than 2 cm in diameter, and their distribution according to echogenic rim were as follows: complete echogenic rim (17/20, 91% mean thickness 2.2 cm) and uneven thickness with complete echogenic rim (3/20, 15%, range:2.0-6.1 mm). Twenty-five hemangiomas were larger than 2 cm in diameter and their distribution according to echogenic rim were as follows: complete echogenic rim (n=9, 34%), incomplete echogenic rim (n=16, 64%0,even thickness with complete echogenic rim (3/9, 33%, mean thickness 2.2 mm) and uneven thickness with complete echogenic rim (6/9,67%, range: 2.0-7.6 mm). In statistical analysis, hemangiomas more than 2 cm in diameter were more likely to have incomplete echogenic rim (p<0.05) than those of less than 2 cm; hemangiomas more than with more than 2 cm in diameter and complete echogenic rim showed uneven thickness of echogenic rim (p<0.05), more often than those of less than 2 cm diameter. Hemangiomas with more than 2 cm in diameter showed more frequent incomplete echogenic rim than those of less than 2 cm in diameter, which had more frequent complete echogenic rim. Hemangiomas with complete echogenic rim and even rim

  20. Unusual treatment of Kasabach-Merritt syndrome secondary to hepatic hemangioma: embolization with bleomycin.

    Science.gov (United States)

    Bozkaya, Halil; Cinar, Celal; Ünalp, Ömer Vedat; Parildar, Mustafa; Oran, Ismail

    2015-06-01

    Kasabach-Merritt syndrome (KMS) is a rare complication of cavernous hemangiomas characterized with anemia, thrombocytopenia, and consumption coagulopathy. This syndrome usually develops due to superficial soft tissue hemangiomas in infancy and childhood. KMS developing secondarily to hepatic hemangioma is very rare. In this report, we aimed to present the treatment of KMS developing secondarily to giant cavernous hemangioma of the liver with transarterial chemoembolization using bleomycin.

  1. Torsion of a Giant Pedunculated Hemangioma of the Liver Presenting With Acute Abdomen: A Case Report

    OpenAIRE

    Darzi, Aliasghar; Taheri, Hassan; Kamali Ahangar, Sekineh; Mirzapour Shafiei, Alameh; Asghari, Yasser

    2016-01-01

    Introduction Hemangioma is the most common benign tumor of the liver. Most cases are asymptomatic and do not require treatment. A hemangioma can rarely be pedunculated; as a result, it may undergo torsion and infarction, which can make it symptomatic. Case Presentation We report the case of a 45-year-old woman with acute abdominal pain due to torsion of a giant pedunculated hepatic hemangioma around its vascular stalk. Conclusions Pedunculated hemangioma of the liver is an uncommon benign tum...

  2. MRI findings of cavernous hemangioma of the uterus: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Ji Hwa; Kim, Ok Hwa; Park, Young Mi; Jeng, Hae Woong; Lee, Sun Joo; Eun, Choong Gi; Choi, Su Im; Kim, Gi Tae [College of Medicine, Inje University, Busan (Korea, Republic of)

    2005-12-15

    Hemangioma is the most common soft tissue tumor in the body. Though it may occur anywhere in the body, hemangioma of the uterus is a very rare tumor. Hemangioma is almost asymptomatic, but it is sometimes clinically important because it can cause massive hemorrhage and this is a life-threatening condition. We report here on the magnetic resonance imaging and pathologic findings of cavernous hemangioma of the uterus in a 32-year-woman with menorrhagia.

  3. Deformidad facial postraumática asociada a complicación por silastic orbitario 35 años después de implantado

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    Denia Morales Navarro

    Full Text Available Las alteraciones esqueléticas del macizo facial sin tratamiento quirúrgico o con un manejo inadecuado, pueden resultar en deformidad secundaria importante con implicaciones estéticas y funcionales que deben ser consideradas para su tratamiento. El objetivo de esta presentación fue caracterizar el caso de deformidad facial postraumática asociada a complicación por silastic orbitario, 35 años después de implantado este. Se trata de un paciente masculino de 67 años que refirió haber sido tratado al presentar enrojecimiento de un ojo y secreciones. Refiere que hace 35 años fue intervenido quirúrgicamente por fractura “en la zona del ojo izquierdo”, que le colocaron silastic, y que no había tenido problemas hasta el momento en esa área. En el examen físico facial se detectó asimetría facial: ligero enoftalmo del ojo izquierdo, con desnivel pupilar, disminución de la apertura palpebral, rasgo antimongoloide, con eritema de la conjuntiva, quémosis, y abundantes secreciones. Se comprobó limitación del movimiento súpero-externo. Se corrobora la presencia de una fístula en el fondo de saco del párpado inferior. Se diagnostica como deformidad facial postraumática complicada por reacción a cuerpo extraño (al silastic. Fue intervenido quirúrgicamente y se realizó la exéresis del material, y la reconstrucción de la antomía ausente en la zona con malla de titanio. Se obtuvo excelentes resultados. Las lesiones postraumáticas de la cara se asocian generalmente con grandes secuelas funcionales y estéticas. Si se añaden las complicaciones por el empleo de implantes de biomateriales, la determinación de la conducta terapéutica puede ser un reto.

  4. First reported treatment of aggressive hemangioma with intraoperative radiation therapy and kyphoplasty (Kypho-IORT

    Directory of Open Access Journals (Sweden)

    B. Pinar Sedeño

    2017-02-01

    Full Text Available Aggressive hemangiomas invade the spinal canal and/or paravertebral space and may cause cord compression and neurological symptoms. Radiation therapy was recognized as an effective strategy for the treatment of aggressive hemangiomas. Here, it is reported the first case of aggressive vertebral hemangioma treated by a combination of intraoperative radiation therapy and kyphoplasty (Kypho-IORT.

  5. Cavernous hemangioma of the submandibular gland with parapharyngeal extension in an adult: Case report.

    Science.gov (United States)

    Azadarmaki, Roya; Then, Matthew T; Walia, Rohit; Lango, Miriam N

    2016-02-01

    Cavernous hemangiomas of the submandibular gland are rare. Signs and symptoms typically resemble those of sialolithiasis and chronic sialadenitis. If a lesion extends into the parapharyngeal space, otalgia and sore throat can result. Spontaneous regression is not a characteristic of cavernous hemangiomas. Surgical excision is a management option. We report the case of an adult with a submandibular gland cavernous hemangioma with parapharyngeal extension.

  6. Our Treatment Results of Circumscribed and Diffuse Choroidal Hemangiomas

    Directory of Open Access Journals (Sweden)

    Esra Savku

    2013-08-01

    Full Text Available Purpose: To discuss our treatment results of choroidal hemangiomas. Material and Method: The records of 39 cases of choroidal hemangioma followed up at our clinic between July 1999–October 2012 were reviewed retrospectively. Asymptomatic cases were followed up. Symptomatic cases with subretinal fluid and impaired vision received treatment. Results: Mean age of the 39 patients was 44 (12-80 years. Thirty-five of 39 cases had circumscribed choroidal hemangioma, and 4 cases had diffuse choroidal hemangioma. Sturge-Weber syndrome was present in 3 cases with diffuse choroidal hemangioma. Cases with circumscribed choroidal hemangioma and minimal subretinal fluid were treated with TTT in 11 cases, PDT in 12 cases, and PDT+TTT in 1 case. Cases with circumscribed choroidal hemangioma and excessive subretinal fluid were treated with Ru-106 plaque radiotherapy in 1 case, Ru-106 plaque radiotherapy+TTT in 1 case, EBRT in 3 cases, and TTT+EBRT in 1 case. One painful blind eye with neovascular glaucoma and complicated cataract was enucleated. Cases with diffuse choroidal hemangioma and excessive subretinal fluid were treated with Ru-106 plaque radiotherapy+TTT in 1 case and EBRT in 1 case. Ahmed glaucoma valve implantation and FAKO emulsification were applied to a case with neovascular glaucoma and complicated cataract. Complete resorption of subretinal fluid was achieved in 23 (72% of treated 32 cases. When mean initial tumor thickness was 2.6 mm (0.5-6, mean final tumor thickness was 1.4 mm (0-6. When mean initial visual acuity (LogMAR was 1.5 (0-3, mean final visual acuity was 1.1 (0-3. No recurrence was observed. Discussion: The amount of the subretinal fluid determines the method of treatment in circumscribed choroidal hemangioma. While TTT and PDT are effective treatment modalities for minimal subretinal fluid, plaque radiotherapy and EBRT are applied in cases with excessive subretinal fluid. Combination therapies may be necessary according to the

  7. Clinical and radiologic features of submandibular triangle hemangioma.

    Science.gov (United States)

    Cho, Jung-Hae; Nam, In-Chul; Park, Jun-Ook; Kim, Min-Sik; Sun, Dong-Il

    2012-07-01

    The clinical and radiologic features of submandibular triangle hemangioma have not been systematically reported. Hemangiomas in the submandibular triangle are very rare and are often misdiagnosed as other benign cystic masses or inflammatory conditions. We retrospectively reviewed the medical records of 5 patients who underwent surgery for submandibular triangle hemangioma between January 2006 and April 2011. All patients presented with fluctuating swelling with or without pain in the submandibular triangle. Computed tomographic (CT) scans showed cystic masses around the submandibular glands and calcified nodules in the lesions. Ill-defined vascular lesions and variably sized hard nodules were identified during surgery. Bleeding was controlled by early ligation of feeding vessels. The submandibular gland was removed for surgical exposure in 4 patients. Pathologic review of each specimen revealed that all were cavernous hemangiomas with thrombosis and phleboliths. Complications included 1 temporary marginal mandibular nerve paresis and 1 postoperative hematoma. No recurrence after surgery was seen during a follow-up period of 4 to 52 months. The possibility of submandibular triangle hemangioma should first be considered when a cystic mass around the submandibular gland and multiple calcifications are present on CT. Ligation of feeding vessels and resection of the submandibular gland may be needed to obtain surgical exposure and prevent massive bleeding.

  8. Hepatic cavernous hemangioma in cirrhotic liver: imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jeong Sik; Kim, Ki Whang; Park, Mi Suk; Yoon, Sang Wook [College of Medicine, Yonsei University, Seoul (Korea, Republic of)

    2000-12-01

    To document the imaging findings of hepatic cavernous hemangioma detected in cirrhotic liver. The imaging findings of 14 hepatic cavernous hemangiomas in ten patients with liver cirrhosis were retrospectively analyzed. A diagnosis of hepatic cavernous hemangioma was based on the findings of two or more of the following imaging studies: MR, including contrast-enhanced dynamic imaging (n=10), dynamic CT (n=4), hepatic arteriography (n=9), and US (n=10). The mean size of the 14 hepatic hemangioma was 0.9 (range, 0.5-1.5) cm in the longest dimension. In 11 of these (79%), contrast-enhanced dynamic CT and MR imaging showed rapid contrast enhancement of the entire lesion during the early phase, and hepatic arteriography revealed globular enhancement and rapid filling-in. On contrast-enhanced MR images, three lesions (21%) showed partial enhancement until the 5-min delayed phases. US indicated that while three slowly enhancing lesions were homogeneously hyperechoic, 9 (82%) of 11 showing rapid enhancement were not delineated. The majority of hepatic cavernous hemangiomas detected in cirrhotic liver are small in size, and in many, hepatic arteriography and/or contrast-enhanced dynamic CT and MR imaging demonstrates rapid enhancement. US, however, fails to distinguish a lesion of this kind from its cirrhotic background. (author)

  9. El maltrato infantil

    OpenAIRE

    Gloria Robaina Suárez

    2014-01-01

    Se estudia el maltrato infantil desde sus antecedentes, así como su tipología, causas y consecuencias. Además de abordar el abuso sexual de forma más amplia. También se expone la evaluación psicológica junto con sus técnicas. Es fundamental la utilización de medidas para la prevención del maltrato infantil, pues una gran parte de los problemas en el niño se ven reflejados en su vida adulta

  10. Cavernous hemangioma concurrently involving the anterior and middle mediastinum and the lung parenchyma: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jee Hyun; Lee, Soo Jung; Kim, Sung Jin; Cho, Bum Sang [Dept. of Radiology, Chungbuk National University Hospital, Cheongju (Korea, Republic of)

    2017-04-15

    Hemangioma is rarely found in the mediastinum or lung. In the mediastinum, this tumor is usually located in the anterior mediastinum and manifests as a nonspecific soft tissue mass. In the lung, it usually presents as a well-defined nodule. To the best of our knowledge, there is no case of cavernous hemangioma concurrently involving the mediastinum and lung parenchyma, except for one case of concurrent cardiac and pulmonary hemangiomas. Here, we present an interesting case of cystic anterior and middle mediastinal masses together with multiple pulmonary nodules and ground glass opacities, which were diagnosed as cavernous hemangiomas. When similar findings are encountered, clinicians should consider hemangioma in the differential diagnosis.

  11. A Giant Scrotal Cavernous Hemangioma Extending to the Penis and Perineum: A Case Report

    Directory of Open Access Journals (Sweden)

    Osman Ergün

    2009-10-01

    Full Text Available Cavernous hemangioma is a congenital, benign vascular tumor that occurs in the deep dermis and subcutaneous tissue. Scrotal hemangiomas are rare entities and are usually diagnosed in childhood. Adult scrotal hemangiomas are also extremely rare. They are infrequently encountered in adults because they are usually removed in childhood. Urologists often face difficulties in deciding surgery to treat a genital cavernous hemangioma. Here, we report a case of scrotal cavernous hemangioma that involved the entire penis and scrotum, and extended to the perineum in a 44-year-old man, and we review the literature.

  12. A giant scrotal cavernous hemangioma extending to the penis and perineum: a case report.

    Science.gov (United States)

    Ergün, Osman; Ceylan, Berit Gokce; Armagan, Abdullah; Kapucuoglu, Nilgun; Ceyhan, A Murat; Perk, Hakki

    2009-10-01

    Cavernous hemangioma is a congenital, benign vascular tumor that occurs in the deep dermis and subcutaneous tissue. Scrotal hemangiomas are rare entities and are usually diagnosed in childhood. Adult scrotal hemangiomas are also extremely rare. They are infrequently encountered in adults because they are usually removed in childhood. Urologists often face difficulties in deciding surgery to treat a genital cavernous hemangioma. Here, we report a case of scrotal cavernous hemangioma that involved the entire penis and scrotum, and extended to the perineum in a 44-year-old man, and we review the literature.

  13. Propranolol inhibits growth of hemangioma-initiating cells but does not induce apoptosis

    Science.gov (United States)

    Kum, Jina J.Y.; Khan, Zia A.

    2014-01-01

    Background Infantile hemangioma (IH) is the most common tumor of infancy. The first-line therapy for IH is propranolol, a non-selective β-adrenergic receptor antagonist. However, mechanisms for the therapeutic effect of propranolol and regrowth of IH following cessation of treatment in some cases are not clear. We have recently shown that IH arises from multipotent stem cells. Whether IH stem cells are responsive to propranolol and are selectively targeted is unknown, and is the focus of this study. Methods IH stem cells were exposed to propranolol and assayed for cellular and molecular alterations. We used endothelial cells (ECs) as controls and bone marrow-mesenchymal progenitor cells (bm-MPCs) as normal stem/progenitor counterparts to determine selectivity. Results Our results show that propranolol significantly reduced IH stem cell growth but failed to induce caspase-3 activation. Normal bm-MPCs and mature ECs showed maintained or increased caspase-3 activation and significantly reduced cyclin-D1 levels. We further show that IH stem cells may escape apoptosis by inducing anti-apoptotic pathways. Conclusions This study reveals that propranolol does not induce apoptosis in IH stem cells, which is in contrast to ECs. Escape from apoptosis in IH stem cells may involve induction of anti-apoptotic pathways. PMID:24296797

  14. Manejo del enoftalmos como secuela de fracturas del complejo cigomático-orbitario con apoyo de estereolitografía Management of enophtalmos as sequelae of zygomatic complex orbital fractures with stereolitography model support

    Directory of Open Access Journals (Sweden)

    H. Malagón Hidalgo

    2011-03-01

    Full Text Available El enoftalmos postraumático se define como la discrepancia entre el volumen orbitario y su contenido; este balance puede verse alterado por múltiples factores, como el secuestro tardío del contenido orbitario por atrapamiento en el sitio de la fractura, herniación del contenido orbitario, necrosis del tejido adiposo orbitario, contracción cicatricial del tejido retrobulbar, pérdida del sistema de suspensión ligamentario del globo ocular y aumento de volumen de la cavidad orbitaria. El presente estudio aborda el problema del enoftalmos postraumático como una deformidad difícil de corregir. Están descritos abordajes cutáneos extensos como el coronal, el subciliar o el intraoral; la técnica descrita por Henry Kawamoto en 1998 describe un procedimiento de menor invasión mediante abordajes de mínima exposición que permiten la refracturación y el alineamiento del cuerpo zigomático, brindando así grandes ventajas sobre las técnicas convencionales. Presentamos el método aplicado en el servicio de Cirugía Reconstructiva del Centro Médico del Instituto de Seguridad Social del Estado de México y Municipios (ISSEMyM para el manejo de pacientes con enoftalmos como secuela de traumatismos del complejo cigomático-malar; para ello empleamos un método por asistencia con modelos estereolitográficos para la planificación quirúrgica del diseño de osteotomías para corregir la deformidad facial y para determinar las dimensiones del defecto a reparar, así como el tipo y cantidad de materiales aloplásticos o autólogos a emplear. Compartimos la experiencia de los casos tratados en nuestro Servicio entre 2006 y 2010.Post-traumatic enophthalmos is defined as the discrepancy between the orbital volume and its content; this balance can be altered by many factors, such as the entrapment or herniation of the orbital content at the fracture site, orbital adipose tissue necrosis, scar contraction of the retrobulbar tissue, loss of the eyeball

  15. A case of pedunculated hepatic hemangioma mimicking submucosal tumor of the stomach.

    Science.gov (United States)

    Moon, Han Kook; Kim, Hyoung Su; Heo, Gyeong Mi; Shin, Woon Geon; Kim, Kyung Ho; Jang, Myoung Kuk; Lee, Jin Heon; Kim, Hak Yang; Kim, Doo Jin; Cho, Seong Jin

    2011-03-01

    Hepatic hemangioma is the most common benign tumor of the liver. Most such hemangiomas are small, asymptomatic, and have an excellent prognosis. Giant hepatic hemangioma has been reported in the literature, but the exophytic and pedunculated forms of hepatic hemangioma are rare. A 56-year-old woman was referred to our hospital under the suspicion of having a gastric submucosal tumor. Abdominal computer tomography (CT) scans showed a pedunculated mass from the left lateral segment of the liver into the gastric fundus, exhibiting the atypical CT findings of hepatic hemangioma. We therefore decided to perform laparoscopic resection based on the symptoms, relatively large diameter, inability to exclude malignancy, and risk of rupture of the exophytic lesion. The pathology indicated it to be a cavernous hemangioma of the liver. Herein we report a case of pedunculated hepatic hemangioma mimicking a submucosal tumor of the stomach due to extrinsic compression of the gastric fundus.

  16. Cavernous hemangioma of temporalis muscle: report of a case and review of the literature.

    Science.gov (United States)

    Calişaneller, Tarkan; Ozdemir, Ozgür; Yildirim, Erkan; Kiyici, Halil; Altinörs, Nur

    2007-01-01

    Hemangiomas are tumors of vascular origin comprising approximately 7% of all benign tumors. Intramuscular hemangioma is a rare condition and hemangiomas of the head and neck make up less than 15% of intramuscular hemangiomas. Temporalis muscle is an uncommon location for intramuscular hemangioma and seldom reported in the literature. Radiological methods are generally insufficient for the correct diagnosis and surgery is the treatment of choice to exclude malignancy and for adequate treatment of these lesions. A 37-year-old male was admitted with a slowly growing painless mass in his right temporal fossa. The lesion was surgically excised and histopathology confirmed the diagnosis of cavernous hemangioma. Diagnosis and treatment modalities for temporalis muscle hemangiomas are discussed.

  17. Fever of Unknown Origin Caused by Giant Hepatic Hemangioma.

    Science.gov (United States)

    Liu, Xiaolei; Yang, Zhiying; Tan, Haidong; Zhou, Wenying; Su, Yunchao

    2017-08-07

    A 33-year-old man had fever for 2 months. He was admitted by the physician with the suspicion of pneumonia. However, both chest X-ray and computed tomography (CT) showed no abnormality. Tuberculosis and hematological and autoimmune diseases were all excluded. A giant hepatic lesion (20 cm) was detected by ultrasonography with the diagnosis of hemangioma. Contrast enhanced CT scan was conducted and hepatic hemangioma was confirmed. Some areas of the hepatic lesion had lower density compared to surrounding tissues and necrosis of the tumor was suspected. Right trisectionectomy was then performed and the symptom of fever disappeared after the operation. No bacteria grew in the culture of the necrosis tissue. Pathological examination confirmed the diagnosis of hemangioma and the necrosis. He was followed up for 5 months and no fever occurred.

  18. Concomitant cavernous hemangioma and venous angioma of the orbit.

    Science.gov (United States)

    Kodama, Tatsuo; Tane, Nobuhiro; Ohira, Akihiro; Matsuoka, Yotaro; Maruyama, Riruke

    2004-01-01

    An unusual case of cavernous hemangioma coexisting with venous angioma in the ipsilateral orbit is described. A 67-year-old woman had a mass in the lower eyelid of her right eye and proptosis. Imaging examinations showed two masses connected to each other in the extraconal space of the right orbit. Anterior orbitotomy was performed to remove the tumors. Histopathological evaluation of the anteriorly located tumor revealed cavernous hemangioma. The posteriorly located tumor was found to be a venous angioma. Endothelial cells in both tumors showed positive immunostaining for factor VIII-related antigen and smooth muscle actin. Immunoreactivity of smooth muscle actin was more prominent in the interstitium of the posteriorly located tumor. Coexistence of cavernous hemangioma and venous angioma in the same area suggests that they are a continuum and of the same origin. Copyright Japanese Ophthalmological Society 2004

  19. Intraneural hemangioma of the median nerve: A case report

    Directory of Open Access Journals (Sweden)

    Sevinç Teoman

    2008-02-01

    Full Text Available Abstract Hemangiomas of the median nerve are very rare and, so far, only ten cases of intraneural hemangioma of this nerve have been reported in the literature. We present a case of 14-year-old girl who had a soft tissue mass in the region of the left wrist with signs and symptoms of carpal tunnel syndrome. Total removal of the mass was achieved using microsurgical epineural and interfasicular dissection. The symptoms were relieved completely, after this procedure, without any neurologic deficit. On follow-up two years later, no recurrence was observed. Whenever a child or young adult patient presents with CTS the possibility of a hemangioma involving the median nerve should be kept in mind in the differential diagnosis.

  20. A rare cause of recurrent gastrointestinal bleeding: mesenteric hemangioma

    Directory of Open Access Journals (Sweden)

    Zeytunlu Murat

    2009-01-01

    Full Text Available Abstract Lower gastrointestinal hemorrhage accounts for approximately 20% of gastrointestinal hemorrhage. The most common causes of lower gastrointestinal hemorrhage in adults are diverticular disease, inflammatory bowel disease, benign anorectal diseases, intestinal neoplasias, coagulopathies and arterio-venous malformations. Hemangiomas of gastrointestinal tract are rare. Mesenteric hemangiomas are also extremely rare. We present a 25-year-old female who was admitted to the emergency room with recurrent lower gastrointestinal bleeding. An intraluminal bleeding mass inside the small intestinal segment was detected during explorative laparotomy as the cause of the recurrent lower gastrointestinal bleeding. After partial resection of small bowel segment, the histopathologic examination revealed a cavernous hemagioma of mesenteric origin. Although rare, gastrointestinal hemangioma should be thought in differential diagnosis as a cause of recurrent lower gastrointestinal bleeding.

  1. Hemangioma intra-atrial esquerdo Capillary-type cardiac hemangioma, in the left atrium

    Directory of Open Access Journals (Sweden)

    Adalberto Freire Sobrinho

    2005-12-01

    Full Text Available É apresentado o caso de paciente de 49 anos, sexo feminino, com ecocardiograma e cateterismo cardíaco mostrando massa intra-atrial esquerda, sugerindo mixoma, encaminhada para avaliação cardiológica devido à dispnéia. A paciente era ainda portadora de hepatoesplenomegalia esquistossomótica. Após preparo pré-operatório, que incluiu assistência hematológica, a paciente foi submetida a tratamento cirúrgico, com auxílio de circulação extracorpórea. Apresentou sangramento aumentado no pós-operatório imediato, melhorando após transfusão de plaquetas. O estudo anatomopatológico revelou tratar-se de hemangioma capilar benigno.A 49-year-old woman, whose echocardiography and hemodynamic study showed a mass in the left atrium suggestive of myxoma, was referred for cardiological evaluation because of dyspnea. She also had schistosomotic hepatosplenomegaly. After a preoperative evaluation with hematological assistance, the patient underwent surgery using a cardiopulmonary bypass. She suffered a hemorrhage in the immediate post-operative period, which improved after platelet transfusion. The histopathologic study showed a capillary-type cardiac hemangioma.

  2. Hyperlexia in Infantile Autism.

    Science.gov (United States)

    Whitehouse, Dennis; Harris, James C.

    1984-01-01

    Followup of 20 boys (from 7-17 years old) diagnosed with infantile autism revealed Ss' compulsion to decode written materials without comprehension of its meaning. Major differences in intelligence and verbal and nonverbal abilities were noted. It is suggested that the presence of hyperlexia may identify a subgroup of autistic children. (Author/CL)

  3. Infantile hypertrophic pyloric stenosis

    DEFF Research Database (Denmark)

    Pedersen, Rikke Neess; Garne, Ester; Loane, Maria

    2008-01-01

    OBJECTIVE: The objective of this study was to present epidemiologic data on infantile hypertrophic pyloric stenosis (IHPS) from seven well-defined European regions, and to compare incidence and changes in incidence over time between these regions. METHODS: This was a population-based study using...

  4. Transcatheter Arterial Embolization Alone for Giant Hepatic Hemangioma.

    Directory of Open Access Journals (Sweden)

    Jun-Hui Sun

    Full Text Available Giant hepatic hemangioma is a benign liver condition that may be treated using surgery. We studied the digital subtraction angiographic (DSA characteristics of giant hepatic hemangioma, and the effectiveness of transcatheter arterial embolization (TAE alone for its treatment. This was a retrospective study of 27 patients diagnosed with giant hepatic hemangioma and treated with TAE alone (using lipiodol mixed with pingyangmycin at the Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, between January 2010 and March 2013. The feeding arteries were identified using DSA. All patients were followed up for between three weeks and 12 months. Changes in tumor diameter and symptoms were observed. The 27 patients included had giant hepatic hemangiomas ranging from 5.3 to 24.5 cm (mean, 11.24±5.08 cm in the right (n = 13, left (n = 1 or both (n = 13 lobes. Preoperative hepatic angiography showed multiple abnormal vascular lakes in the early phase, known as the "early leaving but late returning, hanging nut on a twig" sign. On the day after TAE, hepatic transaminase levels were increased (ALT: 22.69±17.95 to 94.88±210.32 U/L; ALT: 24.00±12.37 to 99.70±211.54 U/L; both P<0.05, but not total bilirubin. Six patients complained of abdominal pain, and 12 experienced transient fever. In the months after TAE, tumor size decreased (baseline: 11.24±5.08; 3 months: 8.95±4.33; 6 months: 7.60±3.90 cm; P<0.05, and the patients' condition improved. These results indicated that TAE was effective and safe for treating giant hepatic hemangioma. TAE may be a useful alternative to surgery for the treatment of hepatic hemangioma.

  5. Symptomatic hemangioma of oral cavity treated with CO2 laser

    Science.gov (United States)

    Nicola, Ester M. D.; Coutinho, Adriana A.; Nicola, Jorge H.; Gusmao, Reinaldo J.

    1995-05-01

    The CO2 laser has been used by our group as a secure and efficient tool for the treatment of symptomatic oral cavity hemangiomas which can be responsible for disturbance for swallowing, phonation and in hygienic, besides discomfort and bleeding to patients. During the last four years, twelve patients with symptomatic oral cavity hemangioma were treated at the Laser Unit of our University. The treatment consisted in the application of CO2 laser at medium to low intensity according to characteristics and location of the lesions. For hemangiomas located at sites of easy surgical access such as anterior 1/3 of the tongue, lips, bucal vestibule we use 10 to 37 J/mm2 over the surface of the lesion. When the hemangioma was located at difficult surgical access sites, such as, tonsils, posterior 1/3 of tongue, or at pharyngeal wall we used 3.0 to 4.0 J/mm2 encircling the whole hemangioma. This causes reduction in the size of the lesion throughout sclerosis of nutrition vessels. After this initial procedure we applied 0.8 to 1.0 J/mm2 over the whole extent of the lesion. For both procedures we observed no significant bleeding or inflammatory reaction. The patients referred minimal post-operative discomfort with good cicatricial evolution. The evident reduction in the vascularization and size could be confirmed by photographic documentation. The good results described above, with disappearance of symptoms lead to the conclusion that CO2 laser is an efficient and secure method of treatment for symptomatic hemangioma of the oral cavity.

  6. Gamma Knife Radiosurgery for Choroidal Hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yun Taek; Kang, Se Woong [Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lee, Jung-Il, E-mail: jilee@skku.edu [Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2011-12-01

    Purpose: Patients with choroidal hemangioma (CH), a benign ocular hamartoma, frequently presents with visual disturbance as a result of exudative retinal detachment (RD), which originates in subretinal fluid accumulation. We report our experience using the Leksell Gamma Knife in the management of symptomatic CH. Methods and Materials: Seven patients with symptomatic CH (circumscribed form in 3 patients and diffuse form in 4) were treated with the Leksell Gamma Knife at our institution during a 7-year period. All patients presented with exudative RD involving the macula that resulted in severe visual deterioration. The prescription dose to the target margin was 10 Gy in all cases. The mean tumor volume receiving the prescription dose was 536 mm{sup 3} (range, 151-1,057). The clinical data were analyzed in a retrospective fashion after a mean follow-up of 34.4 months (range, 9-76). Results: The resolution of exudative RD was achieved within 6 months, and the visual acuity of the affected eye had improved at the latest follow-up examination (p = .018) in all patients. No recurrence of exudative RD occurred. Thinning of the CHs was observed in most patients; however, symptomatic radiation toxicity had not developed in any of the patients. Conclusion: Symptomatic CHs can be safely and effectively managed with Gamma Knife radiosurgery using a marginal dose of 10 Gy.

  7. Hepatic hemangioma with normal angiograms: Three case reports

    Energy Technology Data Exchange (ETDEWEB)

    Davis, W.D.; Ferrante, W.A.; Tutton, R.H.; Bowen, J.C. (Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, LA (USA))

    1990-02-16

    Three cases of symptomatic cavernous hemangioma of the liver are reported. All three patients have normal angiograms. A review of the literature shows that the diagnosis of hemangioma may be made noninvasively with a high degree of accuracy. Technetium Tc 99m-labeled red blood cell scanning is very specific, while dynamic computed tomography may be more sensitive for small lesions. A combination of the two modalities makes the diagnosis in greater than 90% of cases. Magnetic resonance imaging is also sensitive and specific. Angiography, as shown in these cases, may not only be questionably indicated, but may be misleading. The treatment for symptomatic lesions is resection, and secondary alternatives are discussed.

  8. [Hemangiomas and superficial vascular malformations of the face and neck].

    Science.gov (United States)

    De Minteguiaga, C; Casasco, A; Guimaraens, L; Deffrennes, D; Herbreteau, D; Racy, E; Pérez Rull, J; Huy, P Tran Ba

    2002-01-01

    Hemangiomas and superficial vascular anomalies of the head and neck form what usually calls the angiomas. Many terms exist in the literature for that reason the classification of the ISSVA, admitted by most of the doctors, helps us in naming the different anomalies. The processing of this pathology needs a multidisciplinary collaboration with doctors of different specialties. The evolution of the radiological, surgical techniques of laser, and who knows, of the research, allows to hope us to cure some of the particularly dangerous anomalies like the arteriovenous malformations. We presented here the different technics used in 2001 in the management of hemangioma and superficial vascular anomalies insisting on a multidisciplinary approach.

  9. [De novo growth of a capillary hemangioma of the conjunctiva].

    Science.gov (United States)

    Fernández-Vega Cueto, L; Tresserra, F; de la Paz, M F

    2014-03-01

    A 22-year-old woman patient, diagnosed with an inclusion cyst of the conjunctiva in the nasal sector of the left eye, who after 2 shot/needle injections in the lesion came to our clinic with a dense subconjunctival hemorrhage in four quadrants and with severe pain. After excision biopsy, a capillary hemangioma of the conjunctiva was diagnosed. Conjunctival capillary hemangioma is mainly a benign lesion, asymptomatic and mostly congenital in origin, its progression or de novo growth is rare in adulthood. Copyright © 2012 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.

  10. Esplenectomia parcial para tratar hemangioma esplênico

    Directory of Open Access Journals (Sweden)

    Andy Petroianu

    Full Text Available Apesar de a esplenectomia ser eficaz na abordagem terapêutica de pacientes com hemangioma esplênico, esse procedimento é acompanhado de elevada morbidade e até mortalidade, principalmente devido à sepse, quando realizado em crianças e adolescentes com sistema imunitário ainda imaturo. Para prevenir os efeitos adversos da asplenia, propõe-se neste artigo a esplenectomia parcial, com a retirada apenas da região do hemangioma, mantendo o restante do baço e preservando suas importantes funções.

  11. Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Ghekiere, Olivier; Galant, Christine; Berg, Bruno Vande [Cliniques Universitaires St. Luc, Department of Radiology, Brussels (Belgium)

    2005-06-01

    Lobular capillary hemangioma is a vascular neoplasm that commonly occurs as a cutaneous tumor. When it involves the skin and mucosal surfaces, ulceration and suppuration may occur, hence the classic term of pyogenic granuloma. Intravenous pyogenic granuloma is a rare solitary form of lobular capillary hemangioma that usually occurs in the veins of the neck and upper extremities. We report the ultrasonographic and magnetic resonance imaging findings of a pyogenic intravenous granuloma localized in the right cephalic vein. The imaging and pathological findings and the differential diagnoses are discussed. (orig.)

  12. Ultrasonographic Findings of Hepatic Hemangioma : Analysis of Echo-Patterns According to Tumor Size

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kang Hoon; Lee, Hae Giu; Choi, Byung Gil; Jung, Jung Im; Lee, Sung Yong; Yim, Jung Ik; Shinn, Kyung Sub [Catholic University College of Medicine, Seoul (Korea, Republic of)

    1995-12-15

    We performed a retrospective analysis of ultrasonographic features of hepatic hemangiomas according to tumor size. After an initial ultrasonographic examination, 5l hepatic hemangiomas in 4l patients were confirmed by one or combined examinations of 99mTc RBC SPECT, computed tomography, magnetic resonance imaging. angiography or ultrasonographic follow up. Definition of margin, internal echogenicity,peripheral rim and posterior enhancement were evaluated by two radiologists. Forty seven cases(92%) of 51 hemangiomas appeared to be well defined. Of 29 hemangiomas with less than 3cm in diameter. 25 cases (86%)showed homogeneous internal echogenicity. Of 22 hemangiomas with above 3 cm in diameter, 16 cases (73%) showed inhomogeneous echogenicity. Of 12 hemangiomas (24%) with peripheral rim, nine cases revealed hyperechoic rim and two hypoechoic rim. The remaining one case showed hyperechoic rim and hypoechoic rim alternately. Hemangiomas with greater than 3cm in diameter had higher incidence of inhomogeneous echogenicity, peripheral rim and posterior enhancement than those less than 3 cm(P<0.05). The majority of small hepatic hemangiomas are well defined homogeneous hyperechoic masses. On the other hand, large hemangiomas tended to have higher incidence of inhomogeneous internal echogenicity, posterior enhancement and a peripheral hyperechoic rim. A hyperechoic mass with a hypoechoic rim should also be considered as a candidate for hepatic hemangioma

  13. Genetisk udredning ved infantile spasmer

    DEFF Research Database (Denmark)

    Hansen, Lars Kjærsgaard; Ousager, Lilian Bomme; Møller, Rikke Steensbjerre

    2012-01-01

    Infantile spasms are a symptom of a severe epileptic encephalopathy. It is important to determine the aetiology for a child's disease. When a standard programme for evaluating the aetiology of the infantile spasms is unsuccessful genetic causes should be considered. We suggest array CGH as the fi......Infantile spasms are a symptom of a severe epileptic encephalopathy. It is important to determine the aetiology for a child's disease. When a standard programme for evaluating the aetiology of the infantile spasms is unsuccessful genetic causes should be considered. We suggest array CGH...

  14. A systematic approach to vertebral hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Gaudino, Simona; Martucci, Matia; Colantonio, Raffaella; Lozupone, Emilio; Visconti, Emiliano; Leone, Antonio; Colosimo, Cesare [Catholic University, School of Medicine, Department of Radiological Sciences, Rome (Italy)

    2015-01-15

    Vertebral hemangiomas (VHs) are a frequent and often incidental finding on computed tomography (CT) and magnetic resonance (MR) imaging of the spine. When their imaging appearance is ''typical'' (coarsened vertical trabeculae on radiographic and CT images, hyperintensity on T1- and T2-weighted MR images), the radiological diagnosis is straightforward. Nonetheless, VHs might also display an ''atypical'' appearance on MR imaging because of their histological features (amount of fat, vessels, and interstitial edema). Although the majority of VHs are asymptomatic and quiescent lesions, they can exhibit active behaviors, including growing quickly, extending beyond the vertebral body, and invading the paravertebral and/or epidural space with possible compression of the spinal cord and/or nerve roots (''aggressive'' VHs). These ''atypical'' and ''aggressive'' VHs are a radiological challenge since they can mimic primary bony malignancies or metastases. CT plays a central role in the workup of atypical VHs, being the most appropriate imaging modality to highlight the polka-dot appearance that is representative of them. When aggressive VHs are suspected, both CT and MR are needed. MR is the best imaging modality to characterize the epidural and/or soft-tissue component, helping in the differential diagnosis. Angiography is a useful imaging adjunct for evaluating and even treating aggressive VHs. The primary objectives of this review article are to summarize the clinical, pathological, and imaging features of VHs, as well as the treatment options, and to provide a practical guide for the differential diagnosis, focusing on the rationale assessment of the findings from radiography, CT, and MR imaging. (orig.)

  15. Modified laparoscopic hepatectomy for hepatic hemangioma.

    Science.gov (United States)

    Bai, Dou-Sheng; Chen, Ping; Qian, Jian-Jun; Yao, Jie; Jin, Sheng-Jie; Wang, Xiao-Dong; Jiang, Guo-Qing

    2015-11-01

    Laparoscopic hepatectomy (LH) using many different surgical techniques has become increasingly popular for the management of hepatic tumors. The performance of surgical procedures involving the least possible impairment is expected increasingly more often by both surgeons and patients. We herein describe a clinical cohort of ten patients with hepatic cavernous hemangioma (HCH) who underwent modified LH (MLH) with a new technique. We herein present the advantages of the low level of impairment during performance of this modified procedure and compare the outcomes of MLH with those of traditional LH (TLH) for HCH. We retrospectively evaluated the treatment outcomes in 24 patients with HCH who underwent MLH (n = 10) or TLH (n = 14) from February 2008 to January 2013. Their demographic, intraoperative, and postoperative variables were compared. MLH was successful in all patients. An electromechanical morcellator allowed for easy extraction of the entire HCH without the use of a cumbersome retrieval bag, enlarged incision, or hand-assisted incision. There was no conversion to an open operation or significant perioperative complications. The operation time (P = 0.037), time to removal of the HCH (P < 0.0001), visual analog scale pain score on the first postoperative day (P = 0.012), time to off-bed activity (P = 0.036), and postoperative hospital stay (P = 0.048) were significantly lower in the MLH group than in the TLH group. MLH involving the use of an electromechanical morcellator provides expedient recovery and minimal postoperative pain and scarring. It is a feasible, effective, and safe surgical procedure and embodies all of the benefits of minimally invasive surgery for patients with HCH.

  16. Cerebral cavernous malformations associated with cutaneous angiokeratomas and hemangiomas.

    Science.gov (United States)

    Whitworth, Walter W; Hick, Ryan W; Nelson, Kelly C; Sidhu-Malik, Navjeet K

    2015-11-01

    We report the case of a 66-year-old man with adult-onset seizures and multiple cerebral cavernous malformations who developed numerous eruptive cutaneous angiokeratomas on the legs, scrotum, abdomen, and back as well as lobular and cavernous hemangiomas on the arms. Genetic analysis demonstrated a mutation in the KRIT1, ankyrin repeat containing gene (also known as CCM1).

  17. [Laparoscope hepatectomy for hepatic hemangioma: a report of 18 cases].

    Science.gov (United States)

    Jiang, Wen-shu; Lu, Bang-yu; Cai, Xiao-yong; Lu, Wen-qi; Liu, Zu-jun; Huang, Fei; Jin, Xiao-jian

    2007-10-01

    To evaluate the feasibility and practicality of laparoscopic hepatectomy for hepatic hemangioma. Candidate for laparoscopic liver resection were 18 cases of hepatic hemangioma from January 2002 to October 2006. The portal bloods stream was blocked by the laparoscope portal blood blocker. The Electric-cautery and ultracision were used for liver transection. Operative procedures included anatomical left hepatectomy in 2 cases, non-anatomical left hepatectomy 1 case, left lobectomy 5 cases, local liver resection 10 cases. Two cases of hepatic hemangioma associated with gallbladder stone were performed cholecystectomy synchronously, 1 case associated with chronic appendicitis were performed appendectomy synchronously. Laparoscopic left liver resection was successfully performed in all 18 cases. The operative duration was (185.4 +/- 55.7) min. The quantity of blood lost during the operation was (416.2 +/- 128.8) ml. The postoperative recovery was smooth and good. No critical complications occurred. The duration for hospitalization was (6.2 +/- 1.0) d. Laparoscope hepatectomy for hepatic hemangioma is safe and feasible.

  18. Lymph node hemangioma in one-humped camel | Aljameel | Open ...

    African Journals Online (AJOL)

    Hemangioma is a benign tumor of blood and lymphatic vessels. It is common in skin, mucosa and soft tissues, and its occurrence in lymph nodes is extremely rare. A 10 year-old she-camel was slaughtered at Nyala slaughterhouse, South Darfur State, Sudan. Grossly, the carcass was emaciated. The left ventral superficial ...

  19. Synovial Hemangioma of the Knee: A Rare Pathology | Yalta ...

    African Journals Online (AJOL)

    A 77 year old female patient was admitted to our clinic with a history of swelling in the right knee. After surgical excision of the mass, the pathological examination was found to be consistent with the synovial hemangioma of the knee which has been rarely reported up till now. Pathologists and clinicians dealing with the ...

  20. Endoscopic endonasal resection of cavernous hemangioma of the palate

    Directory of Open Access Journals (Sweden)

    Kristina Piastro

    2017-11-01

    Full Text Available Hemangiomas are a common presentation in the head and neck, but intraosseous hemangiomas are exceedingly rare and account for only 1% of bone tumors. The hard palate is a unique anatomic structure consisting of mucosa rich in minor salivary glands, and is firmly attached to the palatine process of the maxilla and the horizontal plate of the palatine bone. Neoplasms of the hard palate are extremely rare and may display unique characteristics and histologic findings. Whether benign or malignant, the therapy of choice for such tumors is surgical excision performed through a transoral approach, which carries a significant risk of oronasal and oroantral fistula formation. This paper describes the use of an endoscopic endonasal technique for resection of a rare case of a cavernous hemangioma of the hard palate. Resection of favorable benign lesions like palatal hemangiomas are more likely to be successful via this endoscopic endonasal technique which avoids the traditional transoral palatal approach and thus reduces the risk of oronasal and oroantral fistulae. No complications in the immediate postoperative nor within a 1-year follow-up period were observed.

  1. Hemangiosarcoma subsequent to radiotherapy for a hemangioma in infancy

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, R.G.; Keller, J.W.; Ditty, J.F. Jr.

    1978-11-01

    A case is presented of a 31-year-old white man who developed a hemangiosarcoma in the very place where 30 years ago a hemangioma had been treated by radiotherapy. The rarity of such an occurrence is attested to by the fact that only two similar cases were found in the English medical literature.

  2. Conservative management of cavernous sinus cavernous hemangioma in pregnancy.

    Science.gov (United States)

    Haber, Jessica S; Kesavabhotla, Kartik; Ottenhausen, Malte; Bodhinayake, Imithri; Dinkin, Marc J; Segal, Alan Z; Lee, Young M; Boockvar, John A

    2014-06-01

    Cavernous sinus cavernous hemangiomas in pregnancy are extremely rare lesions. The precise management of these lesions remains unknown. The authors present a case of a cavernous hemangioma in pregnancy, centered within the cavernous sinus that underwent postpartum involution without surgical intervention. A 34-year-old pregnant patient (gravida 1, para 0) presented to an otolaryngologist with persistent headache and left-sided facial pain and numbness in the V1 distribution. While being treated for sinusitis, her symptoms progressed to include a left-sided oculomotor palsy and abducens palsy. Magnetic resonance imaging without contrast revealed an expansile mass within the left cavernous sinus consistent with a cavernous hemangioma. The patient was evaluated by a neurosurgeon who recommended close follow-up and postpartum imaging without surgical intervention. Although the lesion enlarged during pregnancy, the patient was able to undergo an uncomplicated cesarean section at 37 weeks. All facial and ocular symptoms resolved by 9 months postpartum, and MRI showed a decrease in lesion size and reduced mass effect. The authors conclude that nonsurgical management may be a viable approach in patients who have an onset or exacerbation of symptoms associated with cavernous sinus cavernous hemangiomas during pregnancy because postpartum involution may negate the need for surgical intervention.

  3. [OVARIAN ANASTOMOSING HEMANGIOMA WITH STROMAL LUTEINIZATION: A CASE REPORT].

    Science.gov (United States)

    Metodiev, D; Ivanova, V; Omainikova, B; Boshnakova, Tz

    2015-01-01

    In 2009, Montgomery and Epstein coined the term "anastomosing hemangioma" for a newly described variant of capillary hemangioma with an unusual sinusoidal pattern, histologically mimicking angiosarcoma. The lesion was considered unique for genitourinary system with predilection to kidney but we found in the literature only 4 cases of this entity in ovaries. A 70-year-old woman presented with ultrasound visualized myometrial nodules and cystic formation of the right ovary, intraoperatively diagnosed as serous cystadenoma. Hysterectomy with bilateral adnexectomy was performed. The section of the ovary revealed a fortuitous finding in the cortex: circumscribed lesion, 7 mm in diameter, with mahogany brown, spongy appearance. Microscopic examination of H&E-stained slides manifested well-demarcated but un-encapsulated vascular proliferation, composed of tightly packed capillary-sized blood vessels with an anastomosing sinusoidal-like architecture and tortuous "feeding" and "draining" vessels of medium caliber. Endothelial lining featured only mild cytologic atypia and lack of mitotic figures. The lesion was surrounded by luteinized ovarian stroma. Immunohistochemical examination with CD34 highlighted endothelial cells; SMA--supporting stromal cells. The anastomosing hemangioma of the ovary with stromal luteinisation was diagnosed as accidental finding. The authors discuss morphological characteristics of anastomosing hemangioma and the unusual for menopausal women but quite often combination between this lesion in the ovary and stromal luteinisation.

  4. INFANTILE IATROGENIC CUSHING'S SYNDROME

    OpenAIRE

    Katar, Selahattin; Akdeniz, Sedat; ?zbek, M Nuri; Yarami?, Ahmet

    2008-01-01

    High potency or/and extended use of topical corticosteroids, particularly in children, may cause suppression of the hypothalamopituitary-adrenal axis. However, iatrogenic Cushing's syndrome in infantile age group is very rare and only a few patients have been reported to date in the literature. Here, we report a case of iatrogenic Cushing's syndrome in a 6-month-old male child whose parents have admitted to the hospital for overweight and skin fragility.

  5. Infantile iatrogenic Cushing's syndrome.

    Science.gov (United States)

    Katar, Selahattin; Akdeniz, Sedat; Ozbek, M Nuri; Yaramiş, Ahmet

    2008-01-01

    High potency or/and extended use of topical corticosteroids, particularly in children, may cause suppression of the hypothalamopituitary-adrenal axis. However, iatrogenic Cushing's syndrome in infantile age group is very rare and only a few patients have been reported to date in the literature. Here, we report a case of iatrogenic Cushing's syndrome in a 6-month-old male child whose parents have admitted to the hospital for overweight and skin fragility.

  6. Ruptured hepatic cavernous hemangioma: a case report and literature review; Hemangioma cavernoso hepatico roto: relato de caso e revisao da literatura

    Energy Technology Data Exchange (ETDEWEB)

    Paula Neto, Walter Teixeira de [Hospital Uniclinicas, Chapeco, SC (Brazil). Servico de Radiologia e Diagnostico por Imagem], e-mail: walterteixeira21@yahoo.com.br; Koifman, Ana Celia Baptista [Hospital Municipal Souza Aguiar, Rio de Janeiro, RJ (Brazil); Martins, Carlos Alberto de Souza [Sociedade Brasileira de Radiologia (SBR), Rio de Janeiro, RJ (Brazil); Clinica Life Imagem, Rio de Janeiro, RJ (Brazil)

    2009-07-15

    Hepatic hemangioma is frequently asymptomatic, and bleeding is rare, even in cases of large lesions. The authors report the case of a 31-year-old female patient presenting with acute abdominal pain, whose imaging studies have demonstrated hematoma in the left hepatic lobe associated with hemo peritoneum. The patient was submitted to left hepatectomy, with a final histopathological diagnosis of cavernous hemangioma. (author)

  7. Role of pigment epithelium-derived factor in the involution of hemangioma: Autocrine growth inhibition of hemangioma-derived endothelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyung-Jin [Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Department of Biomedical Science, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Yun, Jang-Hyuk; Heo, Jong-Ik [Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Lee, Eun Hui [Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137-701 (Korea, Republic of); Min, Hye Sook [Department of Pathology, Seoul National University Hospital, Seoul 110-744 (Korea, Republic of); Choi, Tae Hyun, E-mail: psthchoi@snu.ac.kr [Department of Plastic and Reconstructive Surgery, Seoul National University Children’s Hospital, Seoul 110-744 (Korea, Republic of); Department of Pediatric Plastic and Reconstructive Surgery, Seoul National University Children’s Hospital, Seoul 110-744 (Korea, Republic of); Cho, Chung-Hyun, E-mail: iamhyun@snu.ac.kr [Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Department of Biomedical Science, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Cancer Research Institute, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of)

    2014-11-14

    Highlights: • PEDF was expressed and induced during the involuting phase of IH. • PEDF inhibited the cell growth of the involuting HemECs in an autocrine manner. • PEDF suppression restored the impaired cell growth of the involuting HemECs. - Abstract: Hemangioma is a benign tumor derived from abnormal blood vessel growth. Unlike other vascular tumor counterparts, a hemangioma is known to proliferate during its early stage but it is followed by a stage of involution where regression of the tumor occurs. The critical onset leading to the involution of hemangioma is currently not well understood. This study focused on the molecular identities of the involution of hemangioma. We demonstrated that a soluble factor released from the involuting phase of hemangioma-derived endothelial cells (HemECs) and identified pigment epithelium-derived factor (PEDF) as an anti-angiogenic factor that was associated with the growth inhibition of the involuting HemECs. The growth inhibition of the involuting HemECs was reversed by suppression of PEDF in the involuting HemECs. Furthermore, we found that PEDF was more up-regulated in the involuting phase of hemangioma tissues than in the proliferating or the involuted. Taken together, we propose that PEDF accelerates the involution of hemangioma by growth inhibition of HemECs in an autocrine manner. The regulatory mechanism of PEDF expression could be a potential therapeutic target to treat hemangiomas.

  8. Apresentações incomuns do hemangioma hepático: ensaio iconográfico Unusual presentations of hepatic hemangioma: an iconographic essay

    Directory of Open Access Journals (Sweden)

    Giuseppe D'Ippolito

    2006-06-01

    Full Text Available O nosso objetivo foi descrever e ilustrar aspectos incomuns do hemangioma hepático na ultra-sonografia (US, tomografia computadorizada (TC e ressonância magnética (RM. A partir da análise retrospectiva de 300 casos de pacientes com diagnósticos de hemangioma hepático, por meio da análise combinada de exames de imagem, biópsia ou acompanhamento clínico, selecionamos aqueles com apresentação atípica em um ou mais métodos de imagem ou aqueles com evolução não usual, ilustrando os seus principais aspectos de imagem. Entre os casos apresentados, escolhemos pacientes com hemangiomas: hipoecogênicos na US; hipovasculares ou avasculares na TC e RM; com calcificações grosseiras; gigantes e medindo mais de 20 cm de diâmetro; predominantemente exofíticos; hipointensos em T2; promovendo defeito de perfusão; com cicatriz central e simulando hiperplasia nodular focal; com crescimento evolutivo. O hemangioma hepático é o tumor mais comum do fígado e geralmente tem apresentação típica. Porém, os seus diversos aspectos não usuais precisam ser conhecidos para auxiliar na orientação diagnóstica e conduta.In order to evaluate atypical aspects of hepatic hemangiomas at ultrasound (US, computed tomography (CT and magnetic resonance imaging (MRI, we have retrospectively analyzed 300 cases of patients diagnosed with hepatic hemangiomas by means of combined imaging studies, clinical follow-up and/or biopsy results. Based on this analysis we have selected those cases with atypical findings at one or more imaging methods or those presenting an unusual evolution such as: hypoechoic nodules at US; giant, heterogeneous hemangiomas; rapidly filling hemangiomas; calcified hemangiomas; pedunculated hemangiomas; hypointense hemangiomas at T2-weighted images; causing perfusion defect; with central scar simulating focal nodular hyperplasia; hemangiomas with adjacent abnormalities such as arterial-portal venous shunt and capsular retraction as well

  9. Tratamiento exitoso de un hemangioma de parótida con propranolol Successful treatment of parotid hemangioma by using propranolol

    National Research Council Canada - National Science Library

    Edelisa Moredo Romo; Fernanda Pastrana Fundora

    2012-01-01

    .... Se presenta el caso clínico de un paciente con diagnóstico de hemangioma de parótida con componente superficial y profundo, tratado con propranolol, con excelente respuesta al tratamiento, involución completa clínica...

  10. Rupture of hepatic hemangioma with hemoperitoneum due to spontaneous gallbladder perforation: A unique case report.

    Science.gov (United States)

    Ke, Qing-Hong; Zhang, Chun-Jun; Huang, Hai-Feng

    2017-02-01

    Hemangiomas are common benign tumors of the liver. Spontaneous rupture is a rare complication, occurring most commonly in giant hemangiomas. Rupture of a hemangioma with hemoperitoneum is a serious development and can be fatal if not managed promptly.The present study reports the unique case of a man who experienced rupture and hemorrhage of a hepatic hemangioma (HH) due to perforation of the gallbladder fundus. After en block resection of the hemangioma and gallbladder using the Pringle maneuver, the patient made an uneventful recovery without complications.To our knowledge, spontaneous rupture of HH secondary to gallbladder perforation has not been reported in the literature. This case highlights a unique, rare cause of ruptured HH and the need to consider appropriate treatment for some hemangiomas to avoid this potentially fatal complication. The current case may provide additional support for treatment of HH due to the potential for spontaneous rupture. For patients with ruptured HH, enucleation with the Pringle maneuver is recommended.

  11. An incidental ovarian mass: A case of ovarian hemangioma with prominent stromal luteinization

    Directory of Open Access Journals (Sweden)

    Babak Shirazi

    2015-01-01

    Full Text Available Ovarian hemangioma is a rare benign tumor of female genital tract. Stromal luteinization in ovarian hemangioma is an uncommon process and the pathogenesis is controversial. In this regard, two hypotheses have been suggested whether luteinization is a reactive process or it is the stimulator for development of ovarian hemangioma. Here, we report a case of a 55-year-old woman who referred to our center due to incidental finding of left ovarian mass in pelvic sonography. Microscopically, the mass showed a mixed cavernous and capillary hemangioma and the peripheral stroma contained several small and large clusters of stromal cells, which were luteinized. It should be noted that an ovarian hemangioma could be associated with stromal luteinization although its pathogenesis is not clearly known. Yet, we believe the stromal luteinization around ovarian hemangioma could be a reactive phenomenon.

  12. Spontaneous Rupture of a Giant Hepatic Hemangioma-Report of a Case

    OpenAIRE

    Gupta, Shahana; Agarwal, Vikash; Acharya, Anadi Nath

    2011-01-01

    Hemangioma is the commonest benign hepatic neoplasm. Most cases are asymptomatic. Spontaneous rupture is rare (1–4%). Only 34 cases have been reported in adults. None had history of trauma. We report a case, the first from India of spontaneous rupture of a giant hepatic hemangioma, in a 25 year old male presenting with acute abdomen. He underwent right hepatectomy. Histopathology suggested cavernous hemangioma.

  13. Spontaneous rupture of a giant hepatic hemangioma-report of a case.

    Science.gov (United States)

    Gupta, Shahana; Agarwal, Vikash; Acharya, Anadi Nath

    2012-10-01

    Hemangioma is the commonest benign hepatic neoplasm. Most cases are asymptomatic. Spontaneous rupture is rare (1-4%). Only 34 cases have been reported in adults. None had history of trauma. We report a case, the first from India of spontaneous rupture of a giant hepatic hemangioma, in a 25 year old male presenting with acute abdomen. He underwent right hepatectomy. Histopathology suggested cavernous hemangioma.

  14. Hemangioma of the prostate--an unusual cause of lower urinary tract symptoms

    DEFF Research Database (Denmark)

    Serizawa, Reza R; Nørgaard, Nis; Horn, Thomas

    2011-01-01

    Hemangioma of the prostate gland is extremely rare and only a few cases have been reported. There have been several cases of hemangioma of posterior urethra, urinary bladder and periprostatic plexus in the literature, all presenting with hematuria or hematospermia. Diagnosis of prostatic hemangioma...... is difficult due to its rarity and unspecific symptoms such as hematuria, hematospermia or lower urinary tract symptoms. It cannot be detected by conventional examinations such as cystoscopy or standard rectal ultrasonography....

  15. Diffuse Cavernous Hemangioma of the Penis, Scrotum, Perineum, and Rectum - A rare tumor

    Directory of Open Access Journals (Sweden)

    Rastogi Rajul

    2008-01-01

    Full Text Available Hemangiomas are benign lesions that occur in any part of the body. Genital hemangioma involving the entire penis and scrotum are extremely rare. More rarely they can extend in to the pelvis making preoperative imaging imperative and decisive in treatment. Very few cases have been reported in the medical literature. Hereby, a rare cavernous hemangioma that involves the entire penis, scrotum and extends into perineum and rectum in an 18-year-old male is presented with review of literature.

  16. Pre-operative Arterial Embolization of Symptomatic Giant Hemangioma of the Liver

    Directory of Open Access Journals (Sweden)

    Mustafa Kayan

    2012-01-01

    Full Text Available The cavernous hemangiomas of the liver are usually small sized and asymptomatic. Most of them are incidentally diagnosed and a very small portion requires therapy. Giant hemangioma can be symptomatic, and this condition is the indication for treatment. The striking complication of surgical treatment of cavernous hemangiomas is intra-operative bleeding. In this case, we aimed to demonstrate that the risk of intraoperative bleeding can be eliminated with the preoperative percutaneous trans-catheter arterial embolization technique.

  17. Genetisk udredning ved infantile spasmer

    DEFF Research Database (Denmark)

    Hansen, Lars Kjærsgaard; Ousager, Lilian Bomme; Møller, Rikke Steensbjerre

    2012-01-01

    Infantile spasms are a symptom of a severe epileptic encephalopathy. It is important to determine the aetiology for a child's disease. When a standard programme for evaluating the aetiology of the infantile spasms is unsuccessful genetic causes should be considered. We suggest array CGH...

  18. Infantile spasms and pigmentary mosaicism

    DEFF Research Database (Denmark)

    Hansen, Lars K; Bygum, Anette; Krogh, Lotte N

    2010-01-01

    Summary We present a 3-year-old boy with pigmentary mosaicism and persistent intractable infantile spasms due to mosaicism of chromosome 7. Getting the diagnosis of pigmentary mosaicism in a child with infantile spasms may not be easy, as most diagnostic work-up is done in infancy, at a time when...

  19. Infantile sexuality and Freud's legacy.

    Science.gov (United States)

    Marion, Paola

    2016-06-01

    The topic of sexuality and infantile sexuality, though less frequently discussed by psychoanalysis in recent decades, has received renewed attention for some years. The intention of this paper is to share some reflections around the role of infantile sexuality in our thinking, how we encounter it in our work with patients and in clinical material. Through reference to questions put forward by Freud (1905) in Three Essays, this paper takes into consideration some areas of the debate that has developed on the subject of infantile sexuality, starting from Freud's original intuition, including various hypotheses on the genesis of the sexual drive. The author will concentrate on two specific points. Firstly, how infantile sexuality - as a permanent dimension of the subject's existence - unfolds in the relationship and is deeply influenced by it. And that is how in childhood and adolescence, infantile sexuality ushers in parental sexuality - just as, in the case of our patients, infantile sexuality ushers in the analyst's sexuality. The second point pertains to the temporal dimension within which infantile sexuality is inscribed. The hypothesis that the author proposes is that infantile sexuality may be understood in the specific time of psychoanalysis [Nachträglichkeit], distinct and different with respect to the linear, evolutionary dimension. Copyright © 2015 Institute of Psychoanalysis.

  20. "Soap Bubble" Lesion of the Middle Phalanx: Enchondroma or Epitheloid Hemangioma.

    Science.gov (United States)

    Suresh, S S; Etemadi, Jamshid; Bhatnagar, Gunmala

    2014-01-01

    Epitheloid hemangioma, a benign vascular tumor that arises in skin and soft tissues can also involve the skeletal system. Occasionally this has been reported from small tubular bones of the hand. Authors report a case of epitheloid hemangioma of the middle phalanx in a young girl without any cutaneous manifestations. The lesion presented as a swollen middle finger, and plain radiographs showed a geographic area of destruction with cortical thinning and intra lesional calcifications. The case was managed by curettage and bone grafting. Histology confirmed this as a case of epitheloid hemangioma. Epitheloid hemangioma should be considered in the differential diagnosis of hand masses with expansile lytic lesions with cortical thinning.

  1. Transcatheter arterial chemoembolization in patients with hepatocellular carcinoma and coexisting hepatic cavernous hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Ran-Chou [Taipei City Hospital Renai Branch, Department of Radiology, Taipei (Taiwan); Taipei Medical University, Department of Radiology, School of Medicine, Taipei (Taiwan); Lii, Jiunn-Ming; Chen, Wei-Tsung; Tu, Hsing-Yang; Chiang, Liang-Chung [Taipei City Hospital Renai Branch, Department of Radiology, Taipei (Taiwan)

    2006-06-15

    We investigated the consequence of repeated transcatheter arterial chemoembolization (TACE) for coexisting small hepatic hemangioma in the treatment of patients with hepatocellular carcinomas and describe the imaging features of embolized hemangioma on the follow-up Lipiodol CT and MR. Six of 431 patients with biopsy-confirmed hepatocellular carcinomas, who underwent TACE, also had seven small hepatic cavernous hemangiomas (0.8{proportional_to}2.3 cm) in the same area of embolization. All six patients underwent repeated TACE All lesions were evaluated with CT and/or MR for the post-treatment follow-up. The outcomes and imaging features of these embolized hemangiomas were reviewed for the change of tumor size, Lipiodol deposition, enhancing pattern as well as embolization complications. Six of the seven hemangiomas did not depict changes in the size or enhancement pattern without being ablated. One hemangioma showed a decrease in size, but still persisted after TACE. All of the hemangiomas showed Lipiodol deposition for 2{proportional_to}15 months, in which five hemangiomas depicted irregular rim patterns. There is no complication caused by the procedures. The differentiation of small hepatic hemangiomas from viable HCC is important in the post-TACE follow-up to avoid unnecessary repeated embolization. (orig.)

  2. High-Output Heart Failure from a Hepatic Hemangioma With Exertion-Induced Hypoxia.

    Science.gov (United States)

    Smith, Aaron A H; Nelson, Matthew

    2016-01-01

    Patients with hepatic hemangiomas have been known to have high-output heart failure as a result of left-to-right arteriovenous shunting. We report a patient with a hepatic hemangioma that presented with high-output heart failure with hypoxia on exertion. After embolization of the hemangioma, the patient's hypoxia resolved and ejection fraction improved. In the absence of cardiopulmonary pathophysiology, we presume that our patient's hemangioma was causing a right-to-left shunt as opposed to an expected left-to-right shunt. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Spontaneous rupture of hepatic hemangioma: a case report and literature review.

    Science.gov (United States)

    Zhao, Wei; Guo, Xiao; Dong, Jiahong

    2015-01-01

    Hepatic hemangioma, a common benign tumor of the liver, has caused great threats to the public health. Most patients have an excellent prognosis because of the benign nature of hemangioma. On some occasions, spontaneous rupture of hepatic hemangioma is rarely observed in patients. Therefore, a majority of scholars propose that surgery should be restricted to specific situations. In this case, we presented a patient with spontaneous rupture of hepatic hemangioma in our hospital. After a literature review, we summarized the management and outcome of the patient, which revealed the survival rates of the patients are satisfactory.

  4. Iris depigmentation: an unusual complication of intralesional corticosteroid injection for capillary hemangioma

    National Research Council Canada - National Science Library

    Al-Mahdi, Huda

    2010-01-01

    Intralesional injection of corticosteroids has been used successfully in the treatment of adenexal hemangiomas, with advantages of easy administration, rapid action, repeatability, efficacy and safety...

  5. Studies on X-ray computed tomography findings of tumorous hemangiomas of the skin

    Energy Technology Data Exchange (ETDEWEB)

    Okamura, Rieko

    1987-02-01

    X-ray computed tomography (CT) findings were compared with microscopic picture in 18 cases of tumorous hemangiomas of the skin. Eight cases of strawberry mark, six cases of cavernous hemangioma, a case of angioblastoma, a case of angiokeratoma naeviforme and two cases of venous racemous angioma were studied. Strawberry mark showed a lobular, well demarcated density with moderate contrast enhancement by urographin. Cavernous hemangioma showed a well demarcated homogeneous density with smooth surface. In conclusion, CT study is a useful tool in the differential and preoperative diagnosis of tumorous hemangioma.

  6. A Rare Case of Arteriovenous Hemangioma Clinically Mimicking Pigmented Nevus

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    Sri Lestari

    2015-05-01

    Full Text Available Abstrak   Arteriovenous hemangioma (AH adalah lesi jinak pembuluh darah kulit yang jarang, biasanya muncul pada kulit wajah berupa lesi tunggal, meninggi, papul merah, atau keunguan; kadang-kadang papul coklat. Dilaporkan satu kasus AH dengan gambaran klinis menyerupai nevus pada pasien perempuan yang berusia 19 tahun. Ini adalahkasus pertama di Bagian Ilmu Kesehatan Kulit dan Kelamin RS. Dr. M. Djamil Padang. Pasien datang dengan keluhan bintik hitam di lengan kanan bawah sejak satu bulan lalu. Pada pemeriksaan fisik, terdapat papul hitam soliter, dengan ukuran 0,3 x 0, 4 mm, bentuk bulat, skuama halus,  berbatas tegas, pinggir reguler dengan permukaan tidak rata.Berdasarkan pemeriksaan histopatologi, lesi terdiri dari pembuluh darah yang berdinding tebal dan berdinding tipis yang sangat melebar, penuh dengan eritrosit dan dilapisi oleh selapis endotel yang sesuai untuk AH. Arteriovenous hemangioma adalah tumor yang dijumpai pada usia pertengahan hingga dewasa lanjut dengan puncak insiden pada dekade keempat dan kelima kehidupan. Pada kasus ini, umur pasien tergolong dewasa muda dengan gambaran klinis lesi menyerupai nevus pigmentosus. Kata kunci: arteriovenous hemangioma, kasus jarang, nevus pigmentosus Abstract Arteriovenous hemangioma (AH is a rare benign vascular skin lesion, which typically appears in the skin of the face and extremities and  most commonly occurring on the head and neck region with appearances as single, raised, red, or violaceous papules; sometime tan papule. A case of AH clinically mimicking pigmented nevus in 19year-old womanwas reported. This is the first case in Dermatology Department of Dr.M. Djamil Padang Hospital. She complained about a black pimple on the right lower arm since one month. Physical examination: there is a solitare black papule, with 0,3x0,4 mm, round shape, fine scales, well defined, regular border with irreguler surface.Histopathology findings: the lesions consist of thicked-walled and very

  7. Osteotomía de avance del marco orbitario para el tratamiento del exoftalmos endocrino severo Advancement osteotomy of the orbital rim for the treatment of severe endocrine exophthalmos

    Directory of Open Access Journals (Sweden)

    F. Almeida

    2005-04-01

    Full Text Available La orbitopatía tiroidea es una enfermedad debilitante del sistema visual caracterizada por presentar cambios en los tejidos blandos orbitarios y periorbitarios debidos a un proceso inflamatorio, o a la consecuencia del mismo, y que se relaciona con alteraciones sistémicas de la glándula tiroides. Aparte de las alteraciones estéticas que ocasiona, los pacientes pueden presentar queratitis de repetición por exposición, diplopia, dolor retrobulbar, compresión del nervio óptico e incluso ceguera. La cirugía constituye el tratamiento definitivo del exoftalmos en la orbitopatía de Graves, mejorando la proptosis y la visión, así como diminuyendo la sintomatología ocular, con una morbilidad mínima. Presentamos un caso de exoftalmos severo que fue intervenido mediante osteotomía y avance del marco orbitario superior, lateral e inferior, remoción parcial de dos paredes orbitarias y lipectomía. Los resultados estéticos y el alivio de la sintomatología ocular resultaron satisfactorios.Thyroid-associated orbitopathy is a debilitating disease of the visual system that is characterized by changes in the softtissues of the orbit and periorbita as a result of an inflammatory process, or as a consequence of this, and related to systemic disorders of the thyroid gland. Apart from the aesthetic changes that arise, patients may also present persistent keratitis due to exposure, diplopia, retrobulbar pain, compression of the optic nerve and even blindness. Surgery represents the definitive treatment for exophthalmos in Graves’ orbitopathy as improvements are shown in proptosis and vision. A decrease is also experienced in ocular symptomatology and there is minimal morbidity. We present the case of severe exophthalmos that was surgically operated on with an advancement osteotomy of the supero-, lateral- and infraorbital rim, with partial removal of two of the orbital walls with lipectomy. The aesthetic results and the relief of the ocular symptoms

  8. Infantile pyoderma gangrenosum.

    LENUS (Irish Health Repository)

    McAleer, Maeve A

    2008-02-01

    Pyoderma gangrenosum (PG) is rare in infants. There have been 12 cases of PG in infants (<12 months old) reported in the past 25 years, to our knowledge. Six of these cases have been successfully controlled with systemic steroids, and one case with topical steroids alone. We report a case of an 8-month-old infant whose PG was aggressive and unresponsive to systemic steroids. Adjuvant treatment with cyclosporine was required to achieve healing. We review the previous cases of infantile PG and the therapeutic options in this age group.

  9. Behandling af infantile spasmer

    DEFF Research Database (Denmark)

    Kjærsgård, Lars; Rasmussen, Niels

    2006-01-01

    , the data are insufficient to recommend medical treatment with respect to improving the long-term outcome. The adrenocorticotropic hormone and prednisolone are recommended for treatment of IS, although side effects are common. Vigabatrin is also recommended; IS caused by tuberous sclerosis seems to respond......Infantile spasms (IS) are characterised by neurodevelopmental regression, a unique type of seizures and a hypsarrhythmic EEG pattern. Studies recommend the medical treatment of IS as a positive short-term outcome with respect to the spasms and in the resolution of the hypsarrhythmia. However...

  10. Computed tomography and magnetic resonance imaging findings of nasal cavity hemangiomas according to histological type

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jun Ho; Park, Sun Won; Lim, Myung Kwan; Kim, Yeo Ju; Lee, Ha Young [Dept. of Radiology, Inha University School of Medicine, Incheon (Korea, Republic of); Kim, Soo Jin [Dept. of Radiology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Jang, Tae Young [Dept. of Otolaryngology-Head and Neck Surgery, Inha University School of Medicine, Incheon (Korea, Republic of); Kang, Young Hye [Dept. of Radiology, nha University Hospital, Incheon (Korea, Republic of)

    2015-06-15

    To compare computed tomography (CT) and magnetic resonance imaging (MRI) findings between two histological types of nasal hemangiomas (cavernous hemangioma and capillary or lobular capillary hemangioma). CT (n = 20; six pre-contrast; 20 post-enhancement) and MRI (n = 7) images from 23 patients (16 men and seven women; mean age, 43 years; range, 13-73 years) with a pathologically diagnosed nasal cavity hemangioma (17 capillary and lobular capillary hemangiomas and six cavernous hemangiomas) were reviewed, focusing on lesion location, size, origin, contour, enhancement pattern, attenuation or signal intensity (SI), and bony changes. The 17 capillary and lobular hemangiomas averaged 13 mm (range, 4-37 mm) in size, and most (n = 13) were round. Fourteen capillary hemangiomas had marked or moderate early phase enhancement on CT, which dissipated during the delayed phase. Four capillary hemangiomas on MRI showed marked enhancement. Bony changes were usually not seen on CT or MRI (seen on five cases, 29.4%). Half of the lesions (2/4) had low SI on T1-weighted MRI images and heterogeneously high SI with signal voids on T2-weighted images. The six cavernous hemangiomas were larger than the capillary type (mean, 20.5 mm; range, 10-39 mm) and most had lobulating contours (n = 4), with characteristic enhancement patterns (three centripetal and three multifocal nodular), bony remodeling (n = 4, 66.7%), and mild to moderate heterogeneous enhancement during the early and delayed phases. CT and MRI findings are different between the two histological types of nasal hemangiomas, particularly in the enhancement pattern and size, which can assist in preoperative diagnosis and planning of surgical tumor excision.

  11. Synovial hemangioma of the hip joint in a pediatric patient

    Energy Technology Data Exchange (ETDEWEB)

    Demertzis, Jennifer L.; Loomans, Rachel; Wessell, Daniel E. [Washington University School of Medicine, Mallinckrodt Institute of Radiology, St. Louis, MO (United States); Kyriakos, Michael [Washington University School of Medicine, Division of Surgical Pathology, St. Louis, MO (United States); McDonald, Douglas J. [Washington University School of Medicine, Department of Orthopedic Surgery, St. Louis, MO (United States)

    2014-01-15

    Hemangiomas of the articular synovium are rare and commonly associated with recurrent joint swelling and painful limitation of motion. The knee joint is the most commonly involved site, with most patients diagnosed in the second to third decade of life [1]. Although over 200 cases have been reported in the English-language medical literature, only three have originated within the hip joint, all of which were in adult patients reported in the surgical literature [2-4]. We describe a histologically proven synovial hemangioma of the hip joint in a pediatric patient that invaded the femur, acetabulum, and adjacent soft tissues, with a detailed discussion of the differential diagnosis based on the radiographic and magnetic resonance imaging (MRI) findings. (orig.)

  12. Massive hemoptysis caused by tracheal hemangioma treated with interventional radiology.

    Science.gov (United States)

    Zambudio, Antonio Ríos; Calvo, Maria Jose Roca; Lanzas, Juan Torres; Medina, J García; Paricio, Pascual Parrilla

    2003-04-01

    Capillary hemangiomas of the tracheobronchial tree are extremely rare in adults, with hemoptysis being one of the most serious forms of presentation. An operation has been the treatment of choice, although it does involve high rates of morbidity and mortality, especially in emergency situations such as massive hemoptysis, which has led to the search for other therapeutic alternatives. There is no experience with embolization by interventional radiology when the hemoptysis is tracheal in origin, caused partly because the infrequency of this pathology; however, the foundations for it have been laid with the development of embolization for bronchopulmonary pathology. We report a case of a tracheal capillary hemangioma in a 66-year-old woman diagnosed with idiopathic thrombopenic purpura, which began as a massive hemoptysis and was treated successfully with embolization by interventional radiology. There has been no recurrence of the bleeding after 1 year's follow-up, and the patient's control fibrobronchoscopy is normal.

  13. Cavernous hemangioma of the tongue: A rare case report

    Directory of Open Access Journals (Sweden)

    K A Kamala

    2014-01-01

    Full Text Available Hemangiomas are developmental vascular abnormalities and more than 50% of these lesions occur in the head and neck region, with the lips, tongue, buccal mucosa, and palate most commonly involved. They are considered as hamartomas rather than true neoplasms. Here we report a case of hemangioma of the body of the tongue, discussing the diagnostic aspects and treatment modalities of such lesion and emphasizing the role of the color Doppler ultrasonography, especially in the diagnosis and treatment. Factors such as patient′s age, size and site of lesion and the proximity of lesion to vital structure are paramount in the determination of the therapeutic approach and surgical excision. Even though radiotherapy, cryotherapy, laser therapy, medical treatment, injection of sclerosing substances and the selective embolization of the lingual artery seem to have some efficacy, the author conclude that surgery is the therapy of choice in the isolated vascular lesions of the body of the tongue.

  14. Giant hepatic hemangioma presenting as gastric outlet obstruction.

    Science.gov (United States)

    Aydin, Cemalettin; Akbulut, Sami; Kutluturk, Koray; Kahraman, Aysegul; Kayaalp, Cuneyt; Yilmaz, Sezai

    2013-01-01

    Hemangioma, a most frequently encountered primary benign tumor of the liver, is generally determined incidentally during the course of radiologic tests for other reasons. Most lesions are less than 3 cm and a significant proportion of patients are asymptomatic, although the size and location of the lesion in some patients may be associated with the onset of symptoms. Pressure on the stomach and duodenum of giant hemagiomas developing in the left lobe of the liver, in particular, may result in the development of abdominal pain, nausea, vomiting, and feeling bloated, which are characteristic of a gastric outlet obstruction. A 42-year-old man presented with findings of gastric outlet obstruction and weight loss as a result of a giant hepatic hemangioma.

  15. Computed tomography in the evaluation of hepatic hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Hirai, K.; Kumagai, M.; Hinosaka, T. (Kurume Univ., Fukuoka (Japan). School of Medicine)

    1981-05-01

    Computed Tomography (CT) was performed on 6 patients with hepatic hemangioma. Three patients had CT scans before and after an intravenous drip infusion of contrast medium. The other 3 patients had CT scans before and after an intravenous bolus injection of contrast medium. Scans were obtained at variable times extending to 45 minutes for these 3 patients. CT numbers were also obtained. 1) Hepatic hemangioma appears as a low density area on plain CT scan. 2) Scans show the lesion to be an isodense or high density area after a drip infusion of contrast medium. 3) Serial scans show early peripheral opacification of the lesion for several minutes after a bolus injection of contrast medium. 4) Scans examined at variable times up to 45 minutes after the injection demonstrated a progressive central enhancement of the lesion. 5) No side effects occurred after a bolus injection of contrast medium.

  16. Treatment of oral hemangioma with sclerotherapy: case report

    Directory of Open Access Journals (Sweden)

    Salomão Israel Monteiro Lourenço Queiroz

    2014-09-01

    Full Text Available Hemangiomas are benign neoplasms that are common in the head and neck, but relatively rare in the oral cavity. They can cause esthetic and functional impairment, depending on location. The most common site is the upper lip, but they can occur in other areas, such as the tongue, buccal mucosa and palate. Treatment is primarily dependent on correct diagnosis of the lesion and on its anatomic location. The purpose of this article is to provide a description of a case of a hemangioma on the upper lip, treated by therapeutic sclerosis with monoethanolamine oleate (Ethamolin®, covering clinical characteristics and methods for diagnosing these lesions. Precise diagnosis and appropriate therapeutic management resulted in satisfactory esthetic and functional results, with total regression of the lesion and no signs of relapse at 1-year follow-up.

  17. Painful erections secondary to rare epithelioid hemangioma of the penis.

    Science.gov (United States)

    Barber, Evan; Domes, Trustin

    2014-09-01

    Epithelioid hemangioma is a rare benign vascular tumour that atypically involves the penis and usually presents as a painful nodule. A 35-year-old man presented with a 5-month history of painful erections without a clinically apparent lesion or deformity. Magnetic resonance imaging (MRI) with pharmacologically induced erection demonstrated a 1.3-cm nodular lesion deep to the skin at the base of his penis. Following local excision of the lesion, which was diagnosed as an epithelioid hemangioma, the patient was symptom free. This case demonstrates a rare etiology of painful erections with a unique presentation. To the authors' knowledge, it is also the first report of MRI with intracavernosal injection of trimix to assess for a specific cause of painful erections.

  18. Adult primary retroperitoneal cavernous hemangioma: a case report

    Directory of Open Access Journals (Sweden)

    He Hang

    2012-12-01

    Full Text Available Abstract Primary retroperitoneal cavernous hemangioma (PRCH in an adult is extremely rare. We report on the diagnosis and treatment of a patient with PRCH with subtle clinical features and atypical findings on imaging scans. A 38-year-old man was admitted to hospital with a 5-day history of epigastralgia after alcohol drinking. Using various imaging methods, we found a giant cyst-like retroperitoneal mass compressing the surrounding organs. Surgical resection of the tumor was performed, and the mass was found to be a cavernous hemangioma measuring 90 × 80 × 60 mm, with a thick fibrotic wall and extensive intracystic hemorrhage. Physicians should be aware that PRCH may mimic a cystic neoplasm, and that a large tumor size probably indicates intracystic hemorrhage. Surgical resection is a curative approach for PRCH.

  19. Vigabatrin for infantile spasms.

    Science.gov (United States)

    Mitchell, Wendy G; Shah, Namrata S

    2002-09-01

    We reviewed 20 infants receiving vigabatrin for infantile spasms. Patients were not enrolled in a formal study. All families obtained the medication abroad. Age at initiation of vigabatrin ranged from 1 to 48 months; nine infants had received prior treatment with various antiepileptic medications. Patients were begun on the lowest practical dose of 125-250 mg/day, with gradual daily increments to a target of 100 mg/kg/day, but maintained at the lowest effective dosage. Video electroencephalogram was obtained to document resolution of spasms and hypsarrhythmia. Of 20 infants, 12 responded with cessation of spasms and resolution of hypsarrhythmia, at doses of 25-135 mg/kg/day (median = 58 mg/kg/day). Partial responses were observed in six patients, whereas two had no response at 111 and 125 mg/kg/day. Additional new seizure types developed in three infants after initial response to vigabatrin. Increasing the vigabatrin did not have any clinical benefit. Vigabatrin is an effective, well-tolerated treatment for infantile spasms. The response is dose-independent, suggesting that starting at a low dose and gradually increasing, rather than beginning with an arbitrary 100 mg/kg/day dose is advantageous.

  20. Right atrial hemangioma in the newborn: Utility of fetal imaging

    Directory of Open Access Journals (Sweden)

    Christopher Baird

    2012-01-01

    Full Text Available We present a rare primary right atrial tumor diagnosed in-utero with fetal echocardiography, and further characterized as a congenital hemangioma with magnetic resonance imaging. Surgical resection was done six days after birth. This case illustrates the complementary roles of evolving advanced imaging techniques for fetuses and infants with congenital heart disease that allows for surgery early in the neonatal period.

  1. Unusual case of congenital/infantile fibrosarcoma in a new born

    Directory of Open Access Journals (Sweden)

    Eddiba Tarik

    2013-01-01

    Full Text Available Congenital infantile fibrosarcoma (CIFS is a rare mesenchymal tumor that is primarily developed in the soft tissue of distal extremities and occasionally in unusual locations such as the lung and retroperitoneum. It occurs mainly in children below the age of 5 years. About 200 cases have been reported in the literature so far, very few of them in new-borns. The prognosis of this tumor is relatively good compared to adult forms. We report an unusual case of CIFS occurring in new-born mimicking an hemangioma and causing hemorrhage in the neonatal period. The tumor is located in the left arm and axilla and associated with a hand malformation. A shoulder amputation is performed after chemotherapy failure. The infant is now two-years old with no recurrence.

  2. El libro infantil en Colombia

    Directory of Open Access Journals (Sweden)

    Patricia Londoño

    1988-01-01

    Full Text Available Sabemos que desde el decenio de 1970 se aceleraron una serie de cambios en la vida de los niños en las ciudades colombianas y en el mundo editorial, que ampliaron el mercado de libros infantiles. Las librerías empezaron a ofrecer mayor variedad y cantidad de dichos libros, los cuales a veces han llegado a ocupar cuartos o secciones enteras. Hoy, Mundo Libro Infantil en Medellín y la librería del Centto Experimental del Libro Infantil y Juvenil en Bogotá trajinan exclusiva mente con este material.

  3. 15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo

    Directory of Open Access Journals (Sweden)

    Yihong Cai

    2018-01-01

    Full Text Available Infantile hemangioma (IH is a common and benign vascular neoplasms, which has a high incidence in children. Although IH is benign, some patients experience complications such as pain, functional impairment, and permanent disfigurement. Treatment options for IH include corticosteroids, surgery, vincristine, interferon or cyclophosphamide. However, none of these modalities are ideal due to restrictions or potential serious side effects. There is thus a great need to explore novel treatments for IH with less side effects. Angiogenesis, vasculogenesis and tumorigenesis are the main features of IH. Tanshen is mostly used in Chinese traditional medicine to treat hematological abnormalities. Therefore, the aim of our study was to evaluate anti-proliferation and anti-angiogenesis effects on hemangiomas cells by extracted Tanshen compounds compared with propranolol, the first-line treatment for IH currently, both in vitro and in vivo. Cell viability, apoptosis, protein expression and anti-angiogenesis were analyzed by CCK8, Annexin V staining, Western blot and tube formation, respectively. The anti-tumor activity in vivo was evaluated using a mouse xenograft model. Fourteen major compounds extracting from Tanshen were screened for their ability to inhibit hemangiomas cells. Of the 14 compounds investigated, 15,16-Dihydrotanshinone I (DHTS was the most potent modulator of EOMA cell biology. DHTS could significantly decrease EOMA cells proliferation by inducing cell apoptosis, which is much more efficient than propranolol in vitro. DHTS increased the expression of several apoptosis-related proteins, including caspase9, caspase3, PARP, AIF, BAX, cytochrome c, caspase8 and FADD and significantly inhibited angiogenesis, as indicated by reduced tube formation and diminished expression of vascular endothelial cell growth factor receptor 2 and matrix metalloproteinase 9. In nude mice xenograft experiment, DHTS (10 mg/kg could significantly inhibit the tumor

  4. Hepatic Angiosarcoma Masquerading as Hemangioma: A Challenging Differential Diagnosis

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    Ana Rita Garcia

    2017-10-01

    Full Text Available Hemangiomas are usually diagnosed based on ultrasound findings. The presence of symptoms, rapid growth or atipical imagiological findings should make us consider other diagnoses, including malignant tumors such as angiosarcomas. We describe the case of a previously healthy 46-year-old female without a history of exposure to carcinogens who presented with abdominal pain for two months. Diagnostic work-up revealed elevated gamma-glutamyl transferase and lactate dehydrogenase levels. Abdominal ultrasound described a large nodular lesion in the right lobe of the liver described as a hemangioma. One month later, a computed tomography-scan was made and revealed the same lesion, which had grown from 13.5 to 20 cm, maintaining typical imaging characteristics of a hemangioma. A right hepatectomy was performed and pathology revealed an angiosarcoma. After surgery, a positron emission tomography-computed tomography scan showed hepatic and bone metastasis. The patient started taxane-based chemotherapy and lumbar palliative radiotherapy, but died 10 months after surgery. This case shows how difficult it is to diagnose hepatic angiosarcoma relying only on imaging findings. Two abdominal computed tomography -scans were performed and none suggested this diagnosis. Angiosarcoma is a very aggressive tumour with an adverse prognosis. Surgery is the only curative treatment available. However, it is rarely feasible due to unresectable disease or distant metastasis.

  5. [Congenital solitary infantile myofibroma: report of two cases].

    Science.gov (United States)

    Lasso Betancor, C E; Vázquez Rueda, F; Vargas Cruz, V; Ayala Montoro, J; Ruiz, Hierro C; Gómez Beltrán, O

    2011-08-01

    The infantile myofibromatosis is a rare pathology usually affecting children under 2 years. More than half are congenital, located in head and neck in a 30% of the cases. Myofibroma is a benign mesenchymal tumor that appear an isolated lesion or multiple, with or without visceral involvement. Case 1: A newborn girl that presents lump in scalp suspected of encefalocele. Ultrasound and RM: solid and heterogeneous mass 4 x 2 cm with increased peripheral vascularisation. Case 2: A 7-month-old baby boy with lump in right occipital zone detected at 4 months. Ultrasound and RM: injury 1 x 1.5 cm in head esplenio muscle suggestive of hemangioma. After surgical total resection, the histological study and immunohistochemical identified the lesion as myofibroma. The evaluation of disease dissemination was normal and the recovery of the patients was favorable. The differential diagnosis of myofibroma must be carried out with other mesenchymal tumors and with non neoplastic injuries characteristics of the region affects. The visceral location and multiple forms worsen the prognosis, so is important do an exhaustive study. Treatment is conservative surgery, but if there is no risk to the child, the possibility of spontaneous regression makes the abstention therapeutic a correct alternative.

  6. A Rare Cause of Macroscopic Hematuria on Eleven-Year-Old Girl: Bladder Hemangioma

    Directory of Open Access Journals (Sweden)

    Sezgin Guvel

    2013-06-01

    Full Text Available Hemangiomas of the urinary tract can arise anywhere along the system. These rare benign lesions can cause life-threatening severe hematuria. We  present an 11-year-old girl with recurrent multiple bladder hemangioma treated with fulguration and review of the literature.  

  7. Treatment of atypically-localized cavernous hemangioma in abdomen with atypical pain

    Directory of Open Access Journals (Sweden)

    Mehmet Ilhan

    2016-01-01

    Conclusion: Cavernous hemangiomas of the liver rarely require treatment. Surgery is one of the options in selected cases and abdominal pain is one of the indications. In patients complaining from persistent abdominal pain, if intraabdominal atypical-localized mass was seen in examinations, hemangioma should be remembered in differential diagnosis.

  8. Re-evaluation of RN blood pool scintigraphy for hepatic hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Sano, Kumiko; Mashima, Yasuoki; Nagase, Masanori; Mori, Yutaka; Kawakami, Kenji (Jikei Univ., Tokyo (Japan). School of Medicine); Tada, Katsuhiko; Ariizumi, Mitsuko

    1989-10-01

    Hemangioma of the liver is benign tumor without any complaints. But some cases of hemangioma are very difficult to diagnose because of their various findings. Blood pool scintigraphy has been applied as a useful modality for diagnosis of hepatic hemangioma. But reports about imaging time are not enough. We evaluated on this study the best imaging time of blood pool scintigraphy for hemangioma. We examined blood pool scintigraphy on 19 foci of the hepatic hemangiomas in 12 patients which were confirmed by angiography, operation, CT, Echo or clinical findings. After 20 mCi of Tc-99m-albumin or Tc-99m-RBC was injected, angiographic phase (30 sec/frame), and blood pool images were obtained in 15, 30 min, 1, 2, 4, 6 and 24 hrs. The imaging time to delineate most clearly the hemangiomas was investigated. As a result, clear images were obtained until 2 hrs after injection. Hemangiomas smaller than 2 cm were failed to detect in any imaging time. This result suggests that blood pool scintigraphy is a useful method for assessment of hepatic hemangiomas. (author).

  9. Tratamiento quirúrgico de los hemangiomas faciales en niños Surgical treatment of facial hemangiomas in children

    Directory of Open Access Journals (Sweden)

    M. Estrada Sarmiento

    2008-08-01

    Full Text Available Los hemangiomas son los tumores de tejido blando más comunes en la infancia. Ocurren aproximadamente en el 5-10% de los niños de un año de edad. A pesar de la frecuencia de estos tumores, su patogénesis no está completamente esclarecida. Aunque el manejo conservador es usualmente propuesto para los hemangiomas que ocurren en la infancia, la presencia de estos tumores en la cara puede resultar en complicaciones severas y proporcionar una indicación para el tratamiento. En este trabajo mostramos cuatros pacientes que recibieron tratamiento quirúrgico antes de los sietes años por las complicaciones severas que incluían sangramientos repetidos, distorsión de las estructuras adyacentes y trastornos visuales. Las técnicas quirúrgicas dependieron de la localización y tamaño de la lesión.Hemangiomas are the most common soft-tissue tumors in childhood. They occur in approximately 5-10% of one-year-old children. Despite their frequency, the pathogenesis of these tumors is not completely clear. Conservative management usually is proposed for hemangiomas that occur in childhood, but the occurrence of these tumors on the face can result in severe complications and may be an indication for treatment. We report four patients who received surgical treatment before the age of seven years for severe complications, including repeated bleeding, distortion of adjacent structures, and vision disorders. The surgical techniques depended on the location and size of the lesion.

  10. New recognition of the natural history and growth pattern of hepatic hemangioma in adults.

    Science.gov (United States)

    Jing, Li; Liang, Huang; Caifeng, Liu; Jianjun, Yan; Feng, Xu; Mengchao, Wu; Yiqun, Yan

    2016-07-01

    Surgical indications for hepatic hemangiomas are still not clearly defined due to limited data on their natural history. This study aimed to investigate the natural history and growth pattern of hepatic hemangiomas in adults. From April 2010 to March 2013, adult patients with hepatic hemangioma who had no prior treatment were enrolled. A routine follow up was performed to observe the natural history of the lesions and their tendency to cause complications. A total of 236 patients were enrolled in the study. The median size of hemangiomas was 4.5 cm (range, 0.6-19.2). During a median follow-up period of 48 months (range, 3-266), 61.0% patients had hemangiomas that increased in size, 23.7% patients had stable lesions and 8.5% patients had hemangiomas that decreased in size. The peak growth period of hemangiomas was in patients of less than 30 years of age (0.46 ± 0.41 cm/year) and the growth rate decreased significantly after 50 years of age (0.21 ± 0.40 cm/year). Hemangiomas of less than 2 cm had the lowest growth rate (0.16 ± 0.42 cm/year). The peak growth rate of hemangioma size was 8-10 cm (0.80 ± 0.62 cm/year), then decreased rapidly to 0.47 ± 0.91 cm/year while the hemangiomas were of more than 10 cm. Only nine patients had severe symptoms caused by hemangioma. No patients presented with hemangioma-related complications. The majority of hepatic hemangiomas have the tendency to increase in size but rarely cause complications. All the hemangiomas can be safely managed by observation, and surgery is only considered for patients with severe complications. © 2016 The Japan Society of Hepatology.

  11. Aspectos incomuns da paracoccidioidomicose infantil

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    Achiléa Lisboa Bittencourt

    1987-12-01

    Full Text Available São relatados dois casos de paracoccidioidomicose (PCM infantil. Em um deles, a principal manifestação da doença foi tumoração abdominal, simulando linfoma maligno não Hodgkin. O outro apresentou acentuado envolvimento articular, com ruptura da cápsula. Representam o segundo e terceiro casos de PCM infantil observados na Bahia, ambos procedentes de áreas urbanas.The authors present two cases of infantil para-coccidioidomycosis. In one case the main presentation was an abdominal mass that mimicked non- Hodgkin lymphoma. In the other case the child had a joint swelling with rupture of the capsule and the clinical diagnosis was piogenic arthritis. They represent the second and third cases of infantile paracoccidioidomycosis observed in the state of Bahia, all coming from urban areas.

  12. Atypical appearance of an hepatic hemangioma with technetium-99m red blood cell scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Larcos, G.; Farlow, D.C.; Gruenewald, S.M.; Antico, V.F. (Westmead Hospital, NSW (Australia))

    1989-11-01

    Three-phase 99mTc red blood cell scintigraphy is an established technique for distinguishing hemangiomas from other focal liver lesions. The most widely recognized feature is the perfusion to blood-pool mismatch characterized by decreased or normal arterial perfusion, with lesion activity which progressively increases over 1-2 hr. Although increased arterial vascularity of hemangiomas has been described, such cases either involved small portions of the lesion only or occurred in lesions not conclusively proven to be hemangiomas. We report a case of an angiography proven hemangioma with increased arterial vascularity involving a significant portion of the lesion as well as intense early blood-pool activity similar to that seen on delayed imaging. This case emphasizes the diverse appearance of hepatic hemangiomas using 99mTc blood cell scintigraphy.

  13. Torsion of a Giant Pedunculated Hemangioma of the Liver Presenting With Acute Abdomen: A Case Report

    Science.gov (United States)

    Darzi, Aliasghar; Taheri, Hassan; Kamali Ahangar, Sekineh; Mirzapour Shafiei, Alameh; Asghari, Yasser

    2016-01-01

    Introduction Hemangioma is the most common benign tumor of the liver. Most cases are asymptomatic and do not require treatment. A hemangioma can rarely be pedunculated; as a result, it may undergo torsion and infarction, which can make it symptomatic. Case Presentation We report the case of a 45-year-old woman with acute abdominal pain due to torsion of a giant pedunculated hepatic hemangioma around its vascular stalk. Conclusions Pedunculated hemangioma of the liver is an uncommon benign tumor, a rare differential diagnosis for a mass located in the upper abdomen. All incidentally detected pedunculated hemangiomas must be surgically managed, as these have a tendency to become torsioned, and there is also a risk of malignancy or rupture. PMID:27781125

  14. Clinical case report: Sclerosing hemangioma of the liver, a rare but great mimicker

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    Siavash Behbahani, MD

    2016-06-01

    Full Text Available Atypical hemangioma (including sclerosing and/or hyalinizing hemangioma of the liver is a rare variant of hepatic hemangioma, which is the most common benign hepatic tumor. Atypical hemangioma can be indistinguishable from malignancy, primary, or metastatic, based on imaging characteristics. We describe a case of a 70-year-old man with weight loss, occasional bloody stool, change in caliber of stool, and laboratory abnormalities who was found to have multiple hepatic lesions concerning for metastases. We demonstrate that knowledge of the appearance of atypical hemangioma and its inclusion in the differential diagnosis of hepatic lesions can alter patient management and be important to consider before invasive therapies are planned.

  15. Clinical and neuroimaging features vertebral radiculopathy in the combination with vertebral hemangiomas

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    Che-honatskaya M.L.

    2012-06-01

    Full Text Available

    Aim of the study: to study the clinical and neuroimaging features of radiculopathy vertebral hemangiomas in conjunction with the vertebrae. Materials and methods. A total of 56 patients with radiculopathy vertebral hemangiomas combined with the vertebrae. Results. The patients in addition to pain, and focal neurological symptoms were observed violation of urination, and chronic venous insuffciency of lower extremities. MRI identifed three types of vertebral hem-angiomas, depending on the structural characteristics. Conclusion. The aim of the study is realized.Most hemangiomas are asymptomatic yourself. Pain and neurological symptoms caused by musculo-tonic component, the presence of disc herniation, changes in the intervertebral joints, ligaments violation. Type III meets the criteria for hemangiomas and requires aggressive surgical treatment.

  16. La obesidad infantil /

    OpenAIRE

    Pellitero Martinez, Cristina

    2013-01-01

    La obesidad infantil es la enfermedad de tipo nutricional que se da con más frecuencia en los niños de los países desarrollados, conlleva riesgos físicos y psicológicos y determinados estudios señalan que puede acortar la esperanza de vida en 13 años. En Castilla y León, la tasa de obesidad entre los niños en edad escolar es del 0,8%. La autora va a recoger datos y a realizar un estudio del desayuno que realizan estos niños por considerarlo la primera comida del día y la más importa...

  17. Hemangioma cavernoso hepático roto: relato de caso e revisão da literatura Ruptured hepatic cavernous hemangioma: a case report and literature review

    Directory of Open Access Journals (Sweden)

    Walter Teixeira de Paula Neto

    2009-08-01

    Full Text Available O hemangioma hepático é frequentemente assintomático e, mesmo quando de grandes dimensões, não mostra tendência a sangramento. Os autores relatam o caso de uma paciente de 31 anos de idade com dor abdominal aguda, cujos exames de imagem evidenciaram hematoma no lobo hepático esquerdo, associado a hemoperitônio. A paciente foi submetida a hepatectomia esquerda, com o diagnóstico histopatológico de hemangioma cavernoso.Hepatic hemangioma is frequently asymptomatic, and bleeding is rare, even in cases of large lesions. The authors report the case of a 31-year-old female patient presenting with acute abdominal pain, whose imaging studies have demonstrated hematoma in the left hepatic lobe associated with hemoperitoneum. The patient was submitted to left hepatectomy, with a final histopathological diagnosis of cavernous hemangioma.

  18. Hepatic hemangioma. Comparison between MR and SPECT in its detection and characterization. Hemangioma hepatico. Comparacion entre RM y SPECT en su deteccion y caracterizacion

    Energy Technology Data Exchange (ETDEWEB)

    Galant Herrero, J.; Marti-Bonmati, L.; Sopena Monforte, R.; Caballero Calabuig, E.; Martinez Rodrigo, J.; Ferrer Puchol, D.; Paniagua Escudero, J.C. (Hospital Doctor Peset. Valencia (Spain))

    1993-01-01

    Given the high prevalence of hepatic hemangioma, diagnostic techniques that differentiate these benign lesions from metastasis, hepatoma, and other malignant diseases are necessary. Twenty-five consecutive patients in whom ultrasonography led to the suspicion of hemangioma were studied by magnetic resonance (MR) and tomographic scintigraphy using 99m Tc-labeled red blood cells. Twenty patients presented 42 hemangiomas. Of the 5 remaining patients, 2 proved to have hepatoma and 3 had metastases. Both MR and SPECT have been shown to be highly sensitive in the diagnosis of hepatic hemangioma (95% and 74%, respectively). The specificity of both techniques was 100%. A diagnostic algorithm is presented, based on the high sensitivity and specificity of the two techniques for the purpose of avoiding unnecessary diagnostic measures. (Author)

  19. Three cases of large retinal capillary hemangiomas treated with verteporfin and photodynamic therapy.

    Science.gov (United States)

    Aaberg, Thomas M; Aaberg, Thomas M; Martin, Daniel F; Gilman, James P; Myles, Robert

    2005-03-01

    To investigate the efficacy of verteporfin and photodynamic therapy in the treatment of large retinal capillary hemangiomas. Case reports of 3 patients with large retinal capillary hemangiomas treated with photodynamic therapy using verteporfin. Standard verteporfin dosages (6 mg/m(2) of body surface area) were given. Both standard and modified photodynamic protocols were followed. Modified protocols included shorter verteporfin infusion times and longer light exposure times. Pretreatment best-corrected Snellen visual acuity of the 3 affected eyes were 20/100, 20/50, and 2/200, respectively. All cases had associated exudative retinal detachments involving the macula. Cases 1 and 2 were classic endophytic retinal capillary hemangiomas. Case 3 was a reactive retinal capillary hemangioma. Case 1 had 2 photodynamic therapy treatments, and after 8 months, visual acuity improved to 20/40. Two years after initiating photodynamic therapy, the visual acuity was 20/30 and there was no reperfusion of the hemangioma. Case 2 had 3 photodynamic therapy treatments. The hemangioma was fibrotic, and 20 months after initiating photodynamic therapy visual acuity improved to 20/30. Case 3 had 1 treatment, 11 weeks later and visual acuity improved to 20/400. Four months after treatment, visual acuity returned to counting fingers because of tractional elevation of the macula as the capillary hemangioma fibrosed. Vitrectomy surgery was performed, and choroidal and retinal neovascularization was discovered. Three months after vitrectomy visual acuity was 20/400. In cases 1 and 2, the capillary hemangioma ultimately regressed, and the exudative detachment resolved. Verteporfin and photodynamic therapy were effective in achieving closure of large retinal capillary hemangiomas. In all cases, the hemangioma underwent fibrosis with consequent macular puckering due to retinal traction. In all cases, the visual acuity improved.

  20. Wedge-shaped parenchymal enhancement peripheral to the hepatic hemangioma : two-phase spiral CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyoung Won; Kim, Tae Kyoung; Han, Joon Koo [College of Medicine and The Institute of Radiation Medicine, Seoul National University, Seoul (Korea, Republic of); Kim, Ah Young; Lee, Hyun Ju [Asan Medical Center, University of Ulsan , Asan (Korea, Republic of); Song, Chi Sung; Choi, Byung Ihn [Seoul City Boramae Hospital, Seoul (Korea, Republic of)

    2000-02-01

    To determine the incidence of hepatic hemangiomas associated with wedge-shaped parenchymal enhancements adjacent to the tumors as seen on two-phase spiral CT images obtained during the hepatic arterial phase and to characterize the two-phase spiral CT findings of those hemangiomas. One hundred and eight consecutive hepatic hemangiomas in 63 patients who underwent two-phase spiral CT scanning during an 11-month period were included in this study. Two-phase spiral CT scans were obtained during the hepatic arterial phase (30-second delay) and portal venous phase (65-second delay) after injection of 120 mL of contrast material at a rate of 3 mL/sec. We evaluated the frequency with which wedge-shaped parenchymal enhancement was adjacent to the hemangiomas during the hepatic arterial phase and divided hemangiomas into two groups according to whether or not wedge-shaped parenchymal enhancement was noted (Group A and Group B). The presence of such enhancement in hemangiomas was correlated with tumor size and the grade of intratumoral enhancement. In 24 of 108 hemangiomas, wedge-shaped parenchymal enhancement adjacent to hepatic tumors was seen on two-phase CT images obtained during the hepatic arterial phase. Mean hemangioma size was 22mm in group A and 24mm in group B. There was no statistically significant relationship between lesion size and the presence of wedge-shaped parenchymal enhancement adjacent to a hemangioma. In 91.7% and 100% of tumors in Group A, and in 9.6% and 17.8% in Group B, hemangiomas showed more than 50% intratumoral enhancement during the arterial and portal venous phase, respectively. Wedge-shaped parenchymal enhancements peripheral to hepatic hemangiomas was more frequently found in tumors showing more than 50% intratumoral enhancement during these two phases (p less than 0.01). Wedge-shaped parenchymal enhancements is not uncommonly seen adjacent to hepatic hemangiomas on two-phase spiral CT images obtained during the hepatic arterial phase. A

  1. INFANTILISM: THEORETICAL CONSTRUCT AND OPERATIONALIZATION

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    Yelena V. Sabelnikova

    2016-01-01

    Full Text Available The aim of the presented research is to define and operationalize theoretically the concept of infantilism and its construct. The content of theoretical construct «infantilism» is analyzed. Methods. The methods of theoretical research involve analysis and synthesis. The age and content criteria are analysed in the context of childhood and adulthood. The traits which can be interpreted as adult infantile traits are described. Results. The characteristics of adult infantilism in modern world taking into account the increasing of information flows and socio-economic changes are defined. The definition of the concept «infantilism» including its main features is given. Infantilism is defined as the personal organization including features and models of the previous age period not adequate for the real age stage with emphasis on immaturity of the emotional and volitional sphere. Scientific novelty. The main psychological characteristics of adulthood are described as the reflection, requirement to work and professional activity, existence of professional self-determination, possession of labor skills, need for selfrealization, maturity of the emotional and volitional sphere. As objective adulthood characteristics are considered the following: transition to economic and territorial independence of a parental family, and also development of new social roles, such as a worker, spouse, and parent. Two options of a possible operationalization of concept are allocated: objective (existence / absence in real human life of objective criteria of adulthood and subjective (the self-report on subjective feeling of existence / lack of psychological characteristics of adulthood. Practical significance consists in a construct operationalization of «infantilism» which at the moment has so many interpretations. That operationalization is necessary for the further analysis and carrying out various researches. 

  2. Tuberculose infantil: estudo retrospectivo

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    Boaventura Antonio dos Santos

    2011-10-01

    Full Text Available Introdução: A tuberculose (TB infantil permanece como uma das doenças mais prevalentes e preocupantes no mundo, sobretudo em nações em desenvolvimento, onde as taxas são ainda mais elevadas e os casos descritos subestimados pela dificuldade em se estabelecer um diagnóstico definitivo. Dessa forma, este estudo tem como objetivo descrever o perfil clínico e epidemiológico dos pacientes com TB infantil pulmonar e extrapulmonar. Métodos: Foram avaliados retrospectivamente, através de questionário, pacientes com idade de até 15 anos, internados no Serviço de Pediatria do HCPA, no período de janeiro de 2002 a setembro de 2007.   Resultados: Dos 52 pacientes incluídos, 63% apresentavam TB pulmonar. Das formas extra-pulmonares, a meningoencefalite foi a mais prevalente (22%. Comorbidades foram dectadas em 31 (60% pacientes, dos quais 15 (29% apresentavam desnutrição grave, 9 (18% HIV positivo e 7 (13% pneumopatia crônica. Das manifestações clínicas, febre e tosse estavam presentes na maioria dos pacientes. O padrão radiológico predominante foi o de consolidação pulmonar (51%. A maioria dos pacientes referia história de contato com paciente bacilífero (64%. Conclusão: A TB pulmonar representa a principal forma de apresentação clínica da TB, sendo o diagnóstico feito de forma presuntiva na maioria dos casos. O diagnóstico baseado na comprovação bacteriológica foi obtido numa minoria de pacientes, demonstrando a importância dos achados clínico-laboratoriais, história epidemiológica e vacinal para o diagnóstico. Nesse sentido, a criação de escores tem se tornado uma ferramenta de fácil acesso e com razoável acurácia para auxiliar o diagnóstico de TB em serviços de baixa complexidade, especialmente o ambulatorial.

  3. Large capillary hemangioma of the temporal bone with a dural tail sign: A case report

    KAUST Repository

    YANG, GUANG

    2014-05-13

    The present study reports a rare case of large capillary hemangioma of the temporal bone with a dural tail sign. A 57-year-old female presented with pulsatile tinnitus and episodic vertigo associated with a ten-year history of an intermittent faint headache. Magnetic resonance imaging revealed a mass in the right petrous bone, which was hypointense on T1-weighted images and heterogeneously hyperintense on T2-weighted images, and showed a dural tail sign following gadolinium administration. Pre-operatively, this tumor was believed to be a meningioma. During surgery, the vascular tumor was removed by a modified pterional approach. A histopathological examination indicated that the tumor was a capillary hemangioma. Although intraosseous capillary hemangiomas are rare, they most frequently affect the temporal bone. Hemangiomas of the temporal bone may mimic other more common basal tumors. The diagnosis is most often made during surgical resection. The dural tail sign is not specific for meningioma, as it also occurs in other intracranial or extracranial tumors. The treatment of intratemporal hemangiomas is complete surgical excision, with radiotherapy used for unresectable lesions. To the best of our knowledge, the present study is the fourth case of intraosseous intracranial capillary hemangioma, but the largest intratemporal hemangioma to be reported in the literature to date.

  4. Emergent orthotopic liver transplantation for hemorrhage from a giant cavernous hepatic hemangioma: case report and review.

    Science.gov (United States)

    Vagefi, Parsia A; Klein, Ingo; Gelb, Bruce; Hameed, Bilal; Moff, Stephen L; Simko, Jeff P; Fix, Oren K; Eilers, Helge; Feiner, John R; Ascher, Nancy L; Freise, Chris E; Bass, Nathan M

    2011-01-01

    Cavernous hemangiomas represent the most common benign primary hepatic neoplasm, often being incidentally detected. Although the majority of hepatic hemangiomas remain asymptomatic, symptomatic hepatic hemangiomas can present with abdominal pain, hemorrhage, biliary compression, or a consumptive coagulopathy. The optimal surgical management of symptomatic hepatic hemangiomas remains controversial, with resection, enucleation, and both deceased donor and living donor liver transplantation having been reported. We report the case of a patient found to have a unique syndrome of multiorgan cavernous hemangiomatosis involving the liver, lung, omentum, and spleen without cutaneous involvement. Sixteen years following her initial diagnosis, the patient suffered from intra-abdominal hemorrhage due to her giant cavernous hepatic hemangioma. Evidence of continued bleeding, in the setting of Kasabach-Merritt Syndrome and worsening abdominal compartment syndrome, prompted MELD exemption listing. The patient subsequently underwent emergent liver transplantation without complication. Although cavernous hemangiomas represent the most common benign primary hepatic neoplasm, hepatic hemangioma rupture remains a rare presentation in these patients. Management at a center with expertise in liver transplantation is warranted for those patients presenting with worsening DIC or hemorrhage, given the potential for rapid clinical decompensation.

  5. Usefulness of Labeled RBC-SPECT Scanning in the Diagnosis of Hepatic Hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyeon Sook; Yang, Woo Jin; Lee, Myung Hee; Chung, Soo Kyo; Shinn, Kyung Sub; Bahk, Yong Whee [Catholic University College of Medicine, Seoul (Korea, Republic of)

    1991-03-15

    The usefulness of {sup 99m}Tc-labeled RBC single photon emission CT (SPECT) scanning in the diagnosis of hepatic heminagiomas was evaluated in 22 patients with various focal hepatic lesions including 15 cases of hemangiomas, 3 cases each of hepatomas and metastasis and 1 case of abscess. The diagnoses were based on ultrasonography and/or CT scanning, clinical stability of lesion for at least 6 months or surgical exploration. Seven cases of 15 hemangiomas were detected by delayed planar RRC scanning, whereas 4 cases were detected by delayed RBC-SPECT scanning. The smallest hemangioma shown by delayed RBC-SPECT scanning was 1.0 cm diameter, compared with 2.2 cm by planar RBC scanning. One small hemangioma (2.0 cm) located adjacent to the heart was not found by either method. The sensitivities in detecting the hemangioma according to the size by planar imaging were 16.6% (l.0-1.9 cm), 66. 7% (2.0-2.9 cm) and 83.3% (more than 3.0 cm) and by SPECT were 50.0%, 66.7% and 100%, respectively. Seven cases of non-hematogenous lesions did not show any significant increase in activity in the delayed blood pool images. It is concluded that {sup 99m}Tc-RBC blood-pool SPECT scanning is clearly more sensitive in detecting small hemangioma than planar scanning and is, therefore, a choice of method for the detection of hepatic hemangioma.

  6. Distinction between hemangioma of the liver and hepatocellular carcinoma: value of labeled RBC-SPECT scanning

    Energy Technology Data Exchange (ETDEWEB)

    Kudo, M.; Ikekubo, K.; Yamamoto, K.; Ibuki, Y.; Hino, M.; Tomita, S.; Komori, H.; Orino, A.; Todo, A.

    1989-05-01

    The role of adding single-photon emission CT (SPECT) to /sup 99m/Tc-labeled RBC imaging of the liver was evaluated by specifically focusing on the differentiation between hepatic hemangioma and hepatocellular carcinoma. Planar RBC imaging followed by blood-pool SPECT scanning was performed in 77 patients with a total of 108 hemangiomas and in 29 patients with a total of 46 hepatocellular carcinomas. All lesions were smaller than 5 cm in diameter. Thirty-six (33%) of 108 hemangiomas were detected by planar delayed RBC imaging, whereas 63 (58%) were detected by the delayed RBC-SPECT scan. The smallest hemangioma shown by delayed RBC-SPECT scanning was 1.4 cm in diameter, compared with 1.7 cm by planar RBC scanning. When confined to nodules larger than 1.4 cm in diameter, 42% of hemangiomas (36/85) were detected by planar delayed RBC imaging, whereas 74% (63/85) were detected by delayed RBC-SPECT. Increase in sensitivity was noted in nodules 2.1-4.0 cm in diameter. No hepatocellular carcinomas were shown by delayed RBC planar or SPECT scans. We concluded that with the addition of SPECT, the sensitivity of delayed RBC scans in the detection of small hemangiomas is considerably improved. Delayed RBC-SPECT scanning can be used to distinguish hemangioma from hepatocellular carcinoma.

  7. Possibilities and potential roles of estrogen in the pathogenesis of proliferation hemangiomas formation.

    Science.gov (United States)

    Sun, Zhi-Yong; Yang, Li; Yi, Cheng-Gang; Zhao, Huan; Han, Da-Li; Yang, Tao; Wang, Lu; Nie, Chun-Lei; Zhang, Guo-You; Yin, Guo-Qian; Wang, Gang; Teng, Xiao-Pin; Fei, Dong-Mei; Wang, Jin; Zhou, Wen-Kai; Li, Yang; Liu, Bin; Liu, Yin; Zhang, Man-Jing; Wu, Shang-Min; Zhang, Xi; Pan, Hua; Xiao, Bo; Zhao, Ke-Feng; Liu, Dan; Guo, Shu-Zhong

    2008-08-01

    Hemangiomas, often categorized as angiogenic diseases, are the most common tumors of infancy, the life span of which is generally divided into proliferating phase, involuting phase, and involuted phase. Despite their high prevalence, the mechanism leading to proliferation hemangiomas formation is poorly understood and the best approach to their management remains controversial. None of the current therapeutic modalities is ideal, partly because the pathogenesis of hemangioma and the mechanism of its proliferation are far from clear. Many clues reveal that estrogen has an important role in developing the vascular system, experimental and clinical evidences accumulated in recent years also suggest the potential for estrogen to influence neovascularization. Based on those, we hypothesize that estrogen play a potential role in the development of hemangiomas, mainly by regulating some key angiogenic factors, including MMP-9, EPCs, VEGF, NO, etc. Accepting the hypothesis to be correct, a therapy that identify estrogen as a potential target for the design of new, more specific treatments can be used to prevent the proliferation hemangiomas formation. The hypothesis may lead a new direction in the study of mechanisms for proliferation hemangiomas formation, and further study of the precise mechanisms for estrogen-induced hemangiomas will produce effective antiestrogens and estrogen receptor antagonists as new medication for the very difficult problem.

  8. Epithelioid hemangioma of the colon: a case report

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    Ronaldo Nonose

    Full Text Available CONTEXT: Epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia is an uncommon benign vascular neoplasm that is usually located on the face or neck. Exceptionally, it has been described affecting the colon, with only two such cases described in the worldwide literature. The aim here was to present a case of primary epithelioid hemangioma of the sigmoid colon with confirmation by immunohistochemical examination. CASE REPORT: A 37-year-old woman had had a complaint of intermittent abdominal pain for six months. Two months after the condition started, she began to present changes in her intestinal habit, with evacuations containing blood and mucus and a weight loss of 4 kg over this period. At physical examination, a palpable mass was noted in the lower left quadrant of the abdomen. Neoplasia of the colon was clinically suspected and she underwent colonoscopy. This demonstrated the presence of a vegetating sessile lesion of approximately 5 cm in diameter, at a distance of 36 cm from the anal margin. It occupied 80% of the intestinal lumen. A biopsy collected during the examination suggested a diagnosis of neoplasia of vascular origin. After surgical resection, histopathological examination of the resected specimen confirmed the diagnosis of epithelioid hemangioma of the colon, which was backed up by the immunohistochemical panel (factor VIII, Ki-67, CD-34. At present, three years after the surgery, the patient is asymptomatic, she has recovered her normal weight and she has normal findings from control colonoscopy. Despite the rarity of neoplasia of vascular origin, this possibility should be considered in the differential diagnosis for colorectal tumors.

  9. Tc-99m RBC SPECT in hepatic cavernous hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Myoung Hoon; Park, Chan H.; Yoon, Seok Nam; Hwang, Kyung Hoon [College of Medicine, Ajou Univ., Suwon (Korea, Republic of)

    2001-07-01

    Hepatic cavernous hemangioma (HCH) is the most common benign hepatic tumor which is detected incidentally during ultrasonography (US) done at health check-up and computed tomography (CT) done for evaluation of metastasis. The aim of the study is to evaluate retrospectively the accuracy of the modality in the diagnosis of HCH at our institution. 229 patients underwent Tc-99m RBC liver SPECT from Nov 16, 1994 to Sep 24, 2001. There were 127 males and 103 females. Their ages ranges from 82 to 17 years with a mean age of 45.8 years. Twenty millicuries of Tc-99m RBCs autologously labeled were injected. SPECT was done in 2-3 hours after the tracer administration and several hours delayed scan was also obtained in some patients. SPECT was performed with low energy high resolution collimators and triple-head gamma camera (MultiSPECT, Siemens medical systems, Inc., Hoffman Estate, III. USA). SPECT was evaluated visually and results were compared with US, CT, MRI, and clinical follow-up. Of the 156 patients a total of 210 hemangiomas were found in RBC liver SPECT. With regard to the distribution of the lesions, 113 cases revealed single; 43 cases depicted multiple HCHs, with 164 in the right lobe and 46 in the left lobe. The size of lesions ranges from 0.9 to 10 cm. Regarding the size of the lesions on radiographic image, 11 were less than 1cm, 144 were 1 to 4 cm, and the others were more than 4 cm in diameter. RBC liver SPECT is none-invasive and very useful method in the diagnosis of hepatic hemangioma in patients with sonographic and computed tomographic suspicion, if the size is more than 1 cm in diameter. The method is used often for confirmation of HCH in our institution.

  10. Cavernous hemangioma presenting marked hyperostosis. A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kobata, Hitoshi; Miyake, Hiroji; Kitamura, Junji; Kajikawa, Hiroshi; Ohta, Tomio

    1988-02-01

    The authors report here a case of hemangioma of the left parietal bone which presented headache and papilledema. This patient is a 37-year-old female who had, prior to admission, complained of increasing headache for one year and blurred vision for three months. She had no history of head injury. Local physical examinations revealed a slight bulging in her left parietal region which was insensitive to palpation and not adherent to the overlying scalp. Neurological examinations revealed bilateral papilledema and an incongruous bitemporal upper quadrant defect in the visual field. All the other neurological and laboratory data were normal. A plain skull roentogenogram showed a 9 x 9 cm osteolytic and characteristic honeycomb lesion in the parietal region. Systemic bone survey revealed a similar lesion in the right tibia which was not histologically examined. A marked accumulation of isotopes was detected on the bone scintigrams at both lesions. Selective external carotid angiograms demonstrated a tumor stain fed by the superficial temporal, occipital, and middle meningial arteries. CT scans of the brain and skull clearly showed a local thickening of and structural changes in the skull bone and also a mass effect on the brain and lateral ventricle. The lesioned bone was removed en bloc and replaced by an artificial bone. It was highly vascular, but not adherent to the overlying dura. The post-operative course was uneventful, and the headache and papilledema disappeared. Hemangioma of the skull presenting marked hyperostosis, as reported above, seems to be rare. In addition, in this case, skeletal angioma without any clinical manifestation was detected. Clinical and radiological pictures of the hemangioma of the skull and other bones were briefly discussed.

  11. Radiologic features of intraosseous hemangioma: A diagnostic challenge

    Directory of Open Access Journals (Sweden)

    Preethi Balan

    2014-01-01

    Full Text Available Intraosseous vascular lesions are rare conditions, comprising only 0.5% to 1% of all intraosseous tumors. They present with variable and atypical radiographic appearances. Because of this variation, no pathognomonic sign exists that can be used to make a definite clinical diagnosis of these tumors. But, early diagnosis of central hemangioma is essential for preventing uncontrollable hemorrhage and even death during biopsy or surgery. The purpose of this article is to stress on the importance of radiology in the timely diagnosis of such lesions, which can prevent the disaster not only to the patient but also to oral surgeon in legal and professional aspects.

  12. Concurrent hepatic hemangioma and solitary fibrous tumor: diagnosis and management.

    Science.gov (United States)

    Kueht, Michael; Masand, Prakash; Rana, Abbas; Cotton, Ronald; Goss, John

    2015-07-24

    Hepatic solitary fibrous tumor (HSFT) is a very rare benign liver tumor without well-defined findings on imaging. Even with multiphase advanced contrast-enhanced liver imaging, a definitive preoperative diagnosis is impossible. The diagnostic process can be further complicated when there are two concurrent lesions with different radiologic appearances. Here, we compare the findings of a commonly encountered liver lesion, hepatic hemangioma, with those of an exceedingly rare lesion, HSFT. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author 2015.

  13. Antenatal diagnosis of congenital hepatic hemangioma: a case report

    OpenAIRE

    Cabrita, SV; Gonçalves, S.; Rodrigues, H.; Guerra, N; Moura, P

    2009-01-01

    Hepatic tumors in children account for only 1 to 5% of all pediatric tumors. Hepatic hemangioma is, however, the third most common tumor of the liver in childhood. We report a case of an antenatal diagnosis of a hepatic tumor detected on a first obstetric ultrasound, at 26(th) week of gestation. It revealed a complex, predominantly solid hepatic lesion with 3 x 3 cm and a marked, essentially peripheral, Doppler blood flow. Fetal echocardiography showed a normal heart besides a vena cava displ...

  14. Epithelioid hemangioma of penis mimicking malignancy: A rare case.

    Science.gov (United States)

    Kishore, Manjari; Bhardwaj, Minakshi; Ahuja, Arvind

    2017-01-01

    Penile epithelioid hemangioma (EH) is a rare vascular neoplasm with no definite etiology. Herein, we report a case of EH of the penis in a 64-year-old man presenting with painless, bleeding mass on the glans penis. The patient underwent local excision, and on histopathological examination, a diagnosis of EH was made. Immunohistochemistry revealed positivity for CD31, smooth muscle antigen, and negative expression of cytokeratin. The present case highlights the importance of histopathology in conjunction with immunohistochemistry to reach a definitive diagnosis of this rare benign entity and differentiating it from the close malignant mimics, thereby avoiding aggressive management of the patients.

  15. An interesting case of angiogenesis in cavernous hemangioma

    Directory of Open Access Journals (Sweden)

    Dipankar Das

    2016-01-01

    Full Text Available Cavernous hemangioma is the most common orbital tumor in adult. There is lot of literatures for clinicopathological features of this tumor. These tumors had been studied for the model of angiogenesis in many of the experimental setups. We present a case of 34-year-old male with this tumor in the left eye with computerized tomography evidence. Postsurgical laboratory findings gave interesting evidence of tumor angiogenesis with tumor endothelial cells and sprouting of the small vessels endothelial cells. Podosome rosette could be conceptualized from the characteristic patterns seen in the tumor.

  16. Infantile osteopetrosis with superimposed rickets.

    Science.gov (United States)

    Gonen, Korcan Aysun; Yazici, Zeynep; Gokalp, Gokhan; Ucar, Ayse Kalyoncu

    2013-01-01

    Rickets is a complication of infantile osteopetrosis and pre-treatment recognition of this complication is important. To describe four children with infantile osteopetrosis complicated by rickets (osteopetrorickets) and review the relevant literature. Retrospective chart analysis of four infants with osteopetrorickets and a systematic review of the relevant literature. We saw five children with infantile osteopetrosis, of whom four had superimposed rickets, for a period of 12 years. The review of the literature (including the current four children), yielded 20 children with infantile osteopetrorickets. The children ranged in age from 2 months to 12 months. In all children, hepatosplenomegaly was found. Sixteen (80%) children had visual impairments and eight (40%) children had hearing impairments. Serum calcium-phosphorus product was less than 30 in 18 children (90%). Twelve children (60%) were hypocalcemic and 18 (90%) were hypophosphatemic. In all children, the radiological examination demonstrated diffuse bony sclerosis and metaphyseal splaying and fraying of long bones. Five children (25%) had pathological fracture of extremities and 15 (75%) had rachitic rosary. Rickets as a complication to infantile osteopetrosis is not uncommon. Skeletal roentgenograms are of critical importance in the diagnosis of both osteopetrosis and superimposed rickets.

  17. Conservative management of neonatal hepatic hemangioma: a report from one institute.

    Science.gov (United States)

    Dong, Kui-Ran; Zheng, Shan; Xiao, Xianming

    2009-06-01

    To summarize the conservative treatment of neonatal hepatic hemangioma at one institute. Fifteen cases of neonatal hepatic hemangioma were managed in our hospital during the previous 5 years. Initial symptoms, combination symptoms, diagnosis, and treatment were analyzed. Initial symptoms were abdominal mass, hepatomegaly, jaundice, and pneumonia. Combination symptoms were multiple skin hemangiomas, pneumonia, and cardiac insufficiency. Ultrasound and CT showed the typical characteristics of the liver hemangioma. There were three types of hepatic hemangioma: nine cases had a single focus, four cases were multiple foci, and two had diffuse changes in the liver. The diameter of a single focus in this group was about 53-99 mm. Four cases of single focus received resection and two received biopsy. Six cases received corticosteroid treatment. The other five cases were kept under observation only. Those with cardiac insufficiency and pneumonia received diuretics and antibiotic treatment. One neonate with cardiac insufficiency and pneumonia had postoperative MODS and died. One patient having multi-focus in the liver gave up the treatment after biopsy. Other patients were followed-up at 5-17 months. Two cases that received total tumor resection did not have recurrence. In those who received conservative therapy, all hemangiomas disappeared within 1 year. The diagnosis of hepatic hemangioma can be made from symptomology, ultrasound, and CT; pathologic samples are not necessary. Corticosteroid therapy is the widely used therapy. Proactive therapy for congestive heart failure is helpful for those endangering liver hemangioma. Surgery can increase the risk of complications and is not advised for treatment of neonatal hepatic hemangioma.

  18. Hepatic hemangioma and metastasis: differentiation with gadoxetate disodium-enhanced 3-T MRI.

    Science.gov (United States)

    Goshima, Satoshi; Kanematsu, Masayuki; Watanabe, Haruo; Kondo, Hiroshi; Shiratori, Yoshimune; Onozuka, Minoru; Moriyama, Noriyuki

    2010-10-01

    The purpose of this study was to evaluate the gadoxetate disodium-enhanced MRI findings of hepatic hemangioma and to investigate the diagnostic performance in differentiating hepatic hemangioma and metastasis. Images of 32 hepatic hemangiomas in 25 patients and of 29 hepatic metastatic lesions in 20 patients were retrospectively reviewed. Two independent readers interpreted hepatobiliary phase images alone, dynamic extracellular phase images alone, and combined hepatobiliary and dynamic extracellular phase images. MRI findings and performance with respect to the differential diagnosis of hemangioma and metastasis were assessed. During the hepatic arterial phase, 11 of the 32 hemangiomas (34%) exhibited early total enhancement, and nine (28%) exhibited peripheral nodular enhancement. A bright dot sign or minimal peripheral enhancement during the late dynamic phase was observed for a small number of lesions (6% and 28%, respectively). Twenty-three of the 29 metastatic lesions (79%) exhibited ring enhancement during the hepatic arterial phase. Twenty-nine hemangiomas (91%) and all of the metastatic lesions exhibited homogeneous or heterogeneous hypointensity during the hepatobiliary phase. The sensitivity, specificity, and area under the receiver operating characteristic curve for the detection of hemangioma were 76%, 81%, and 0.87 for the hepatobiliary phase alone; 97%, 88%, and 0.97 for the dynamic extracellular phase alone; and 97%, 88%, and 0.98 for the combination. Five nodules smaller than 1 cm (four hemangiomas, one metastatic lesion) that exhibited no enhancement during the arterial phase and minimal enhancement during the late dynamic phase were not differentiated. Gadoxetate disodium-enhanced MRI was found useful for differentiating hepatic hemangiomas and metastatic lesions, especially during the dynamic extracellular phase. Only a limited number of lesions smaller than 1 cm in diameter, which exhibited minimal enhancement on late dynamic phase images, were

  19. Incorrecciones del habla infantil

    Directory of Open Access Journals (Sweden)

    María del Pino LECUONA NARANJO

    2009-11-01

    Full Text Available En el presente trabajo se pretende dar una visión de algunos rasgos característicos del lenguaje infantil, centrándonos especialmente en el estudio de los niños de 4 a 6 años de edad. Es pues, su finalidad fundamental la descripción y análisis de los rasgos que se pueden observar en la expresión verbal de los preescolares. Las diversas peculiaridades que van a ser objeto de examen se refieren a la emisión de incorrecciones de carácter fonético, morfológico y semántico. El análisis unificado de estos tres factores responde a la consideración de que todos surgen como consecuencia de un proceso de simplificación lingüística originado por un estado inconcluso de desarrollo del lenguaje.

  20. HEMANGIOMAS E HEMANGIOSSARCOMAS EM CÃES: ESTUDO RETROSPECTIVO DE 192 CASOS (2002-2014)

    OpenAIRE

    Soares, Nicolle Pereira; Medeiros, Alessandra Aparecida; Szabó, Matias Pablo Juan; Guimarães, Ednaldo Carvalho; Fernandes, Lígia Gundim; Santos, Thaísa Reis dos

    2017-01-01

    Resumo O hemangioma e o hemangiossarcoma são neoplasias mesenquimais originárias do endotélio vascular e o cão é o animal doméstico mais frequentemente acometido. Os registros do Laboratório de Patologia Animal do Hospital Veterinário da Universidade Federal de Uberlândia de 2002 a 2014 foram revisados. Os dados epidemiológicos e a frequência de cães com diagnóstico de hemangioma e hemangiossarcoma foram verificados e estatisticamente comparados. Foram identificados 64 casos de hemangioma e 1...

  1. Intradural Extramedullary Capillary Hemangioma In the Upper Thoracic Spine with Simultaneous Extensive Arachnoiditis.

    Science.gov (United States)

    Lee, Jae Ho; Jeon, Ikchan; Kim, Sang Woo

    2017-06-01

    Capillary hemangiomas are common benign vascular tumors on skin and soft tissues, but developing as an intradural and extramedullary (IDEM) tumor in spine is extremely rare. In this report, we present IDEM tumor compressing thoracic cord in T2-3 level with extensive arachnoiditis below the tumor level in a 60-year-old man. The lesion was removed and histological diagnosis was capillary hemangioma. Prompt diagnosis and resection are important to avoid neurological deterioration from acute hemorrhagic condition. Simultaneous arachnoiditis may be originated from old subarachnoid hemorrhage associated tumor before diagnosis, and we suggest it as a helpful diagnostic feature to suspect vascular tumors such as capillary hemangioma.

  2. Spontaneous Rupture of a Giant Hepatic Hemangioma – Sequential Management with Transcatheter Arterial Embolization and Resection

    Science.gov (United States)

    Jain, Vaibhav; Ramachandran, Vijay; Garg, Rachana; Pal, Sujoy; Gamanagatti, Shivanand R.; Srivastava, Deep N.

    2010-01-01

    Hemangioma is the most common benign tumor of liver and is often asymptomatic. Spontaneous rupture is rare but has a catastrophic outcome if not promptly managed. Emergent hepatic resection has been the treatment of choice but has high operative mortality. Preoperative transcatheter arterial embolization (TAE) can significantly improve outcome in such patients. We report a case of spontaneous rupture of giant hepatic hemangioma that presented with abdominal pain and shock due to hemoperitoneum. Patient was successfully managed by TAE, followed by tumor resection. TAE is an effective procedure in symptomatic hemangiomas, and should be considered in such high risk patients prior to surgery. PMID:20339183

  3. Spontaneous rupture of a giant hepatic hemangioma - sequential management with transcatheter arterial embolization and resection.

    Science.gov (United States)

    Jain, Vaibhav; Ramachandran, Vijay; Garg, Rachana; Pal, Sujoy; Gamanagatti, Shivanand R; Srivastava, Deep N

    2010-01-01

    Hemangioma is the most common benign tumor of liver and is often asymptomatic. Spontaneous rupture is rare but has a catastrophic outcome if not promptly managed. Emergent hepatic resection has been the treatment of choice but has high operative mortality. Preoperative transcatheter arterial embolization (TAE) can significantly improve outcome in such patients. We report a case of spontaneous rupture of giant hepatic hemangioma that presented with abdominal pain and shock due to hemoperitoneum. Patient was successfully managed by TAE, followed by tumor resection. TAE is an effective procedure in symptomatic hemangiomas, and should be considered in such high risk patients prior to surgery.

  4. Anastomosing hemangioma involving the para-arotic region: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Min; KIm, Hyun Cheol; Yang, Dal Mo; Kim, Sang Won; Won, Kyu Yeoun [Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul (Korea, Republic of)

    2017-05-15

    Anastomosing hemangioma (AH) is a rare and benign vascular neoplasm that is regarded as a morphological variant of capillary hemangioma. AH has been encountered primarily in the kidney. To our knowledge, para-aortic involvement of AH has not been reported previously. Here, we report a case of slowly progressing AH involving the left para-aortic region in a 72-year-old woman with a history of breast cancer surgery. A contrast-enhanced, dynamic abdominal CT scan revealed that the lesion had peripheral enhancement with slow centripetal fashion, which is an enhancement pattern similar to that of hepatic hemangioma.

  5. Vertebral hemangioma in the X-ray radiography of Andersson lesion in ankylosing spondylitis

    Energy Technology Data Exchange (ETDEWEB)

    Dihlmann, W.; Delling, G.

    The vertebral cavernous hemangioma is described as the number five cause in the etiology of the Andersson lesion (vertebral-discal destruction in ankylosing spondylitis). In one case of a completely stiffened spine, radiographs showed a vertebral hemangioma with a cockade-like appearance instead of the typical coarse-striated osseous structure. Histologic necropsy results were those of a cavernous vertebral hemangioma. The immobile rigid spine, that is, the pathologically disturbed function appears to have a strong influence on the form, structure and pathology.

  6. Multiple hemangiomas of the urinary bladder in a child with gross hematuria

    Directory of Open Access Journals (Sweden)

    Yeun Yoon Kim

    2015-07-01

    Full Text Available We report a case of multiple hemangiomas involving the urinary bladder in a 4-year-old boy who presented with recurrent episodes of gross hematuria. On ultrasonography, compared with the bladder wall, the lesions presented as multiple isoechoic polypoid intraluminal masses with mildly increased vascularity on color Doppler exam. Cavernous hemangioma was confirmed by cold-cup biopsy, and the all lesions were coagulated with a Holmium laser. Despite their rarity, bladder hemangiomas should be included in the differential diagnosis of multiple intravesical masses in children with gross hematuria.

  7. Unusual features in an adult pancreatic hemangioma: CT and MRI demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Zhi Hua; Wu, Mei [Changshu Hospital of Soochow University, Jiangsu (China)

    2013-10-15

    Hemangiomas in the pancreas are very rare and only a few cases in adulthood have been reported in the literature. We describe a case of pancreatic hemangiomas in an adult with unique imaging findings. A 23-year-old woman visited the hospital for an incidentally detected pancreatic mass. CT and MRI revealed a multilocular cyst with fluid-fluid levels and no obvious enhancement. The patient underwent surgery and the mass was confirmed as a pancreatic hemangioma. The radiological features and differential diagnosis of this rare lesion are discussed.

  8. Infantile amnesia: a neurogenic hypothesis.

    Science.gov (United States)

    Josselyn, Sheena A; Frankland, Paul W

    2012-08-16

    In the late 19th Century, Sigmund Freud described the phenomenon in which people are unable to recall events from early childhood as infantile amnesia. Although universally observed, infantile amnesia is a paradox; adults have surprisingly few memories of early childhood despite the seemingly exuberant learning capacity of young children. How can these findings be reconciled? The mechanisms underlying this form of amnesia are the subject of much debate. Psychological/cognitive theories assert that the ability to maintain detailed, declarative-like memories in the long term correlates with the development of language, theory of mind, and/or sense of "self." However, the finding that experimental animals also show infantile amnesia suggests that this phenomenon cannot be explained fully in purely human terms. Biological explanations of infantile amnesia suggest that protracted postnatal development of key brain regions important for memory interferes with stable long-term memory storage, yet they do not clearly specify which particular aspects of brain maturation are causally related to infantile amnesia. Here, we propose a hypothesis of infantile amnesia that focuses on one specific aspect of postnatal brain development--the continued addition of new neurons to the hippocampus. Infants (humans, nonhuman primates, and rodents) exhibit high levels of hippocampal neurogenesis and an inability to form lasting memories. Interestingly, the decline of postnatal neurogenesis levels corresponds to the emergence of the ability to form stable long-term memory. We propose that high neurogenesis levels negatively regulate the ability to form enduring memories, most likely by replacing synaptic connections in preexisting hippocampal memory circuits.

  9. Diode laser photocoagulation in PHACES syndrome hemangiomas: a case series

    Science.gov (United States)

    Romeo, U.; Russo, N.; Polimeni, A.; Favia, G.; Lacaita, M. G.; Limongelli, L.; Franco, S.

    2014-01-01

    PHACES syndrome is a pediatric syndrome with cutaneous and extra-cutaneous manifestations, such as Posterior fossa defects, Hemangiomas, Arterial lesions, Cardiac abnormalities/aortic coarctation, Eye abnormalities and Sternal cleft. Facial hemangiomas affect the 75% of patients and may arise on the oral mucosa or perioral cutaneous regions. In this study we treated 26 Intraoral Haemangiomas (IH) and 15 Perioral Haemangiomas (PH) with diode laser photocoagulation using a laser of 800+/-10nm of wavelength. For IH treatment an optical fiber of 320 μm was used, and the laser power was set ted at 4 W (t-on 200 ms / t-off 400ms; fluence: 995 J/cm2). For PH treatment an optical fiber of 400 μm at the power of 5 W was used (t-on 100 ms / t-off 300 ms; fluence: 398 J/cm2). IH healed after one session (31%), the other (69%) after two sessions of Laser therapy. In each session, only a limited area of the PH was treated, obtaining a progressive improvement of the lesion. Diode laser photocoagulation is an effective option of treatment for IH and PH in patients affected by PHACE because of its minimal invasiveness. Moreover laser photocoagulation doesn't have side effects and can be performed repeatedly without cumulative toxicity. Nevertheless, more studies are required to evaluate the effectiveness of the therapy in mid and long time period.

  10. Subretinal Hemorrhage after Photodynamic Therapy for Juxtapapillary Retinal Capillary Hemangioma

    Directory of Open Access Journals (Sweden)

    Takayuki Baba

    2011-04-01

    Full Text Available A 75-year-old Japanese woman presented with a juxtapapillary retinal capillary hemangioma (RCH in her left eye. Twelve months after the initial examination, the size of the hemangioma had increased and the exudation from the RCH involved the macula. Her best-corrected visual acuity (BCVA had decreased from 0.8 to 0.3. A total of five intravitreal injections of bevacizumab (IVB; 1.25 mg was given but the RCH did not respond. A photodynamic therapy (PDT was done using multiple laser spots to avoid damaging the optic nerve head. After the first PDT, the subfoveal fluid was reduced but not completely gone. One week after the second PDT, a massive subretinal hemorrhage developed. The subretinal hemorrhage was successfully displaced by injecting intraocular sulfur hexafluoride (SF6 gas. At the 3-year follow-up examination, no subretinal hemorrhage or fluid was observed at the macula and the BCVA remained at 0.05. Our case was resistant to the combination of anti-vascular endothelial growth factor (VEGF and PDT and had a rare massive subretinal hemorrhage. A further collection of RCH cases treated with anti-VEGF and PDT that would justify this treatment is necessary.

  11. Giant cavernous hepatic hemangioma shrunk by use of sorafenib.

    Science.gov (United States)

    Yamashita, Satoyoshi; Okita, Kohsuke; Harada, Katsunori; Hirano, Atsuyoshi; Kimura, Teruaki; Kato, Akira; Okita, Kiwamu

    2013-02-01

    Here we report a case of a 76-year-old man with a giant cavernous hepatic hemangioma of more than 20 cm in diameter. Since the hepatic hemangioma was actually growing and might possibly rupture and he complained of abdominal symptoms, we decided to perform interventional therapy. First we performed transcatheter arterial embolization (TAE) of the hepatic arteries. However, since this was not sufficiently effective, we added sorafenib (600 mg/day). As a result, the tumor shrank with symptomatic improvement. Subsequently, an adverse event occurred, and we suspended the sorafenib therapy. Then, the tumor began to grow, and we resumed administering sorafenib at 400 mg/day. The tumor shrank again, and we continued the sorafenib therapy thereafter. The tumor shrinkage, although possibly induced by the effect of TAE, is considered primarily due to the effect of treatment with sorafenib, because (1) TAE did not sufficiently reduce the blood supply to the inside of the tumor; (2) other tumors shrank in the area not targeted by TAE; and (3) the tumor grew during suspension of sorafenib therapy and shrank again after resuming the treatment.

  12. Autologous fat grafting in lip reconstruction following hemangioma treatment.

    Science.gov (United States)

    Yin, Jiapeng; Li, Haidong; Yin, Ningbei; Wu, Di; Wang, Yongqian; Tong, Haizhou; Li, Yan; Yan, Wei; Fang, Ling; Zhao, Zhenmin

    2013-03-01

    Autologous fat grafting has been successfully used in lip cosmetic surgery. However, little supportive evidence exists for its use in lip reconstruction following hemangioma treatment. Patients with lip deformity following hemangioma treatment at the Plastic Surgery Hospital in Beijing between September 2010 and July 2012 were retrospectively investigated. Twelve patients underwent autologous fat grafting. Aesthetic appearance and texture and volume persistence of the graft were measured preoperatively and postoperatively, and the presence of infection and hematoma was recorded. After a series of 3 to 4 injections and a mean 24 months of follow-up, all 12 patients were satisfied with their aesthetic appearance and the texture and volume persistence of the graft. There were no complications such as infection or hematoma. The current study demonstrates that autologous fat transplantation is a viable option for correction of lip deformities. It is beneficial not only for correction of the tissue defect themselves, but also in terms of its effect on surrounding tissues and its long-lasting results without major complications in the management of this difficult problem.

  13. Hemangiomas cavernosos do cranio: aspectos clinicos, radiologicos e terapeuticos

    Directory of Open Access Journals (Sweden)

    D. Kirchhoff

    1977-12-01

    Full Text Available São discutidos os aspectos relativos ao diagnóstico e tratamento dos hemangiomas cavernosos do crânio. Os dados obtidos em 26 casos, são apresentados, sendo salientado que a localização dos hemangiomas foi maior na região frontal, sendo mais atingido o sexo masculino. Os outros aspectos são coincidentes com os demais autores. A problemática desses tumores, principalmente a sua demonstração radiológica e o seu tratamento, são ressaltados, chegando-se à conclusão final de que o melhor meio de demonstração radiológica é a punção para contrastação direta do tumor. O tratamento de escolha é o cirúrgico, sendo a extirpação em bloco preferida nos casos de comprometimento ósseo importante, sendo a intervenção direta com dissecção e excisão reservada para as localizações nos tecidos moles ou com mínima participação óssea.

  14. Hiperostosis cortical infantil

    Directory of Open Access Journals (Sweden)

    Salvador Javier Santos Medina

    2015-04-01

    Full Text Available La enfermedad de Caffey, o hiperostosis cortical infantil, es una rara enfermedad ósea autolimitada, que aparece de preferencia en lactantes con signos inespecíficos sistémicos; el más relevante es la reacción subperióstica e hiperostosis en varios huesos del cuerpo, con predilección en el 75-80 % de los casos por la mandíbula. Su pronóstico es bueno, la mayoría no deja secuelas. El propósito del presente trabajo es describir las características clínicas, presentes en un lactante de cinco meses de edad, atendido en el Hospital Pediátrico Provincial “Mártires de Las Tunas” con este diagnóstico, quien ingresó en el servicio de miscelánea B por una celulitis facial. Presentaba aumento de volumen en la región geniana izquierda, febrícola e inapetencia. Se impuso tratamiento con cefazolina y se egresó a los siete días. Acudió nuevamente con tumefacción blanda y difusa de ambas hemicaras, irritabilidad y fiebre. Se interconsultó con cirugía maxilofacial, se indicaron estudios sanguíneos y radiológicos. Se diagnosticó como enfermedad de Caffey, basado en la edad del niño, tumefacción facial sin signos inflamatorios agudos e hiperostosis en ambas corticales mandibulares a la radiografía AP mandíbula; unido a anemia ligera, leucocitosis y eritrosedimentación acelerada. El paciente se trató sintomáticamente y con antinflamatorios no esteroideos. Esta rara entidad se debe tener presente en casos de niños y lactantes con irritabilidad y fiebre inespecífica

  15. Synovial hemangiomas of the knee: magnetic resonance findings in six cases; Hemangiomas sinoviales de rodilla: hallazgos de la resonancia magnetica en seis casos

    Energy Technology Data Exchange (ETDEWEB)

    Concepcion, L.; Marti-Bonmati, L. M.; Dosda, R. [Hospital Dr. Peset. Valencia (Spain); Llauger, J.; Palmer, J. [Hospital Santa Creu i Sant Pau. Barcelona (Spain); Mellado, J. M. [Inscanner, S. L. Alicante (Spain)

    1999-05-01

    The synovial hemangioma is an uncommon benign vascular tumor that is difficult to diagnose on the basis of clinical signs Moreover, it has no characteristic radiographic features. The objective of the present report was to describe the MR findings associated with synovial hemangioma of the knee. We review the clinical and MR findings in six patients, with histologically confirmed synovial hemangioma of the Knee, studied with different MR systems and techniques. Synovial hemangiomas were isointense with respect to muscle in T1-weighted images, strongly hyperintense in T2-weighted sequences and presented wavy hypointense linear images. Gadolinium administration resulted in a marked enhancement, although it was heterogeneous in two of three cases analyzed. Although the findings are not pathognomonic, the presence of an intraarticular tumor of the knee that is isointense with respect to muscle in T1 and hyperintense in T2, and shows wavy hypointense images and a marked contrast uptake, may suggest the presence of synovial hemangioma. (Author) 11 refs.

  16. Contrast enhanced ultrasound for the diagnosis of liver hemangiomas - results of a Romanian multicentre study

    DEFF Research Database (Denmark)

    Sirli, Roxana; Sporea, Ioan; Săndulescu, Daniela Larisa

    2015-01-01

    BACKGROUND AND AIM: Contrast enhanced ultrasound (CEUS) has been proven to be a reliable method for the characterization of focal liver lesions (FLL). The aim of this paper was to evaluate the performance of CEUS for the diagnosis of liver hemangiomas in a large cohort of patients. MATERIAL...... for hemangioma if a typical pattern was present following contrast (centripetal fill in during the arterial phase, hyperenhanced lesion during venous and late phases). In all cases a reference method was available (contrast CT or MRI or biopsy). The trial was registered in clinicaltrials.gov (Identifier NCT......01329458). RESULTS: During February 2011 - May 2015, 1153 CEUS examinations were performed for the evaluation of de novo FLL. Out of the 1153 de novo FLL, 238 cases were diagnosed as hemangiomas by CEUS (typical enhancing pattern). Contrast CT/MRI and biopsy diagnosed additional 24 hemangiomas. From...

  17. Detection of bladder hemangioma in a child by blood-pool scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Ishikawa, Ken; Saitoh, Masahiko; Chida, Shoichi [Department of Pediatrics, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka (Japan)

    2003-06-01

    Bladder hemangioma is a rare cause of gross hematuria. A 5-year-old boy was investigated for recurrent episodes of asymptomatic gross hematuria, but no abnormalities were found. Blood-pool scintigraphy using {sup 99m}technetium-human serum albumin combined with diethylene triamine penta-acetic acid (DTPA) revealed an area of increased activity in the right side of the bladder, which was confirmed by cystoscopy as a bladder hemangioma. Endoscopic laser therapy was used to remove two lesions successfully that were diagnosed histologically as cavernous hemangioma. The patient had no further episodes of hematuria in the 2-year period after this treatment. This case study indicates blood-pool scintigraphy may be a useful technique for detecting bladder hemangiomas. (orig.)

  18. Robotic right segmental hepatectomy for the treatment of a giant hepatic hemangioma-a case report.

    Science.gov (United States)

    Efthimiadis, Christoforos; Ioannidis, Aristeidis; Grigoriou, Marios; Kofina, Konstantinia; Lazaridis, Michael; Kosmidis, Christoforos

    2017-06-01

    Hemangioma is the most common benign hepatic tumor. We present the case of a patient with a giant symptomatic hemangioma, treated with segmental liver resection using the Da Vinci Robotic System. A 38-year-old woman presented to our surgical out-patient Department complaining about abdominal discomfort and recurrent episodes of acute abdominal pain. CT-scan and MRI imaging of the abdomen revealed the presence of a giant hepatic hemangioma (>5 cm) involving segments VI and VII. Robotic right segmental hepatectomy was performed. The procedure was successfully completed in 120 min and with intraoperative blood loss of only 450 ml. Postoperative period was uneventful and the patient was discharged on the second postoperative day. In case of giant hemangiomas, a minimally invasive robotic major hepatic resection is a viable option that can be performed with minimal complications. A careful preoperative and intraoperative strategy is required, while significant experience in liver and robotic surgery is mandatory.

  19. Enucleation after Embolization of Liver Failure-Causing Giant Liver Hemangioma

    Science.gov (United States)

    Sharma, Amit; Kaspar, Matthew; Siddiqui, Mohammad; Kim, Joohyun

    2015-01-01

    Patient: Female, 73 Final Diagnosis: Giant liver hemangioma Symptoms: Abdominal discomfort • abdominal enlargement • Icterus Medication: — Clinical Procedure: Enucleation after embolization of liver failure-causing giant liver Specialty: Surgery Objective: Unusual clinical course Background: Hepatic hemangioma is a congenital tumor of the mesenchymal tissues of the liver. While typically benign, these tumors can occasionally grow to sufficient size to cause a number of symptoms, including pain, severe hepatic dysfunction, or, rarely, consumptive coagulopathy. In such instances, surgical treatment may be warranted. Case Report: We present a case of a symptomatic giant hepatic hemangioma in an elderly patient who presented with impending liver failure. She was successfully treated with a combination of surgical enucleation and liver resection after preoperative arterial embolization. We also provide a brief discussion of current treatment options for giant hepatic hemangiomas. Conclusions: Early referral to experienced surgical centers before the onset of dire complications such as severe hepatic dysfunction and liver failure is recommended. PMID:26301888

  20. Pedunculated Hepatic Hemangioma Masquerading as a Peritoneal Tumor. A Case Report.

    Science.gov (United States)

    El Hajjam, Mostafa; Lacout, Alexis; Marzouqi, Mohamed Karji-Al; Lacombe, Pascal; Marcy, Pierre Yves

    2016-01-01

    Although being classically located inside the liver parenchyma, hemangiomas may occasionally develop outside the extra-hepatic capsule, thus appearing as a pedunculated mass. We report the case of a 66-year-old anal cancer female patient presenting with an asymptomatic sub-hepatic mass. Incidental diagnosis of a pedunculated hepatic hemangioma was strongly suggested by the typical imaging features on computed tomography (CT) and magnetic resonance (MR) examinations, and was confirmed by histopathological examination. Exophytic pedunculated growth is a rare and atypical feature of hepatic hemangioma. Thin contrast- enhanced sections and multiplanar CT and MR scan reformations helped to the final diagnosis of hemangioma, showing its origin from the liver edge. Surgical resection is mandatory to prevent threatening mass pedicle torsion.

  1. Clinical effect of hepatectomy versus extracapsular peeling in treatment of hepatic hemangioma

    National Research Council Canada - National Science Library

    CHEN Kai; LI Xiangnong; LIU Kun

    2017-01-01

    ObjectiveTo investigate the clinical effect of hepatectomy versus extracapsular peeling in the treatment of hepatic hemangioma, and to provide a basis for selection of surgical procedure in clinical practice...

  2. A giant cavernous hemangioma of the liver extending into the pelvis

    Directory of Open Access Journals (Sweden)

    Jiayi Kong

    2015-01-01

    Conclusion: Although liver hemangiomas are extremely common, surgical treatment is rarely required. With appropriate indications, and when enucleation is not feasible or ideal, major liver resection is a safe alternative approach with excellent outcomes when performed in the right setting.

  3. Lobular capillary hemangioma of the nasal septum – A case report

    Directory of Open Access Journals (Sweden)

    Panduranga M. Kamath

    2014-11-01

    Full Text Available Lobular capillary hemangioma is a benign, rapidly growing lesion of the skin and mucous membranes. It may rarely present as a mass that entirely fill the nasal cavity with an unknown etiology. Although it has no predilection for age, it is more common in the third decade and in females. Lobular capillary hemangioma usually involves the gingiva, lips, tongue, and buccal mucosa. The nasal cavity is a rare location. The most common symptoms are nasal obstruction and epistaxis. The treatment is nasal endoscopic surgery even for large lesions as it does not require embolization preoperatively. We present a case report of a 45-year-old male patient with lobular capillary hemangioma who presented with epistaxis and nasal obstruction. The diagnosis of capillary hemangioma must always be kept in mind when discussing the differential diagnosis of a rapidly growing bleeding mass of the nasal cavity even though it is a rare entity.

  4. Diagnosis of Hepatic Hemangioma with {sup 99m}Tc-Labeled Red Cells and Single Photon Emission Computed Tomography (SPECT)

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Dae Hyuk; Cho, Shee Min; Lee, Myung Hae; Yang, Suck Kyun; Chung, Young Hwa; Lee, Yung Sang [Asan Medical Center, Ulsan University College of Medicine, Seoul (Korea, Republic of); Shin, Sang Hae; Hong, Kee Suk [Seoul Medical Hospital, Seoul (Korea, Republic of)

    1991-03-15

    The value of {sup 99m}Tc-RBC scintigraphy and SPECT in the diagnosis of hepatic hemangioma was evaluated in 27 patients with 38 hemangiomas and 13 patients with 15 nonhemangiomas. Twenty four (63.2%) of 38 hemangiomas were detected by planar delayed RBC imaging, whereas 30 (78.9%) hemangiomas were detected by the delayed RBC SPECT. Increase in sensitivity was noted in nodules less than 2 cm in diameter. The smallest hemangioma shown by delayed RBC SPECT was 0.9 cm in diameter. All of nonhemangiomatous lesions show normal or decreased activity in delayed blood pool images. We concluded that {sup 99m}Tc-RBC SPECT is an accurate method for the detection of hepatic hemangioma and is more sensitive than planar imaging in depicting small lesions.

  5. Hemangioma of the prostate--an unusual cause of lower urinary tract symptoms

    DEFF Research Database (Denmark)

    Serizawa, Reza R; Nørgaard, Nis; Horn, Thomas

    2011-01-01

    Hemangioma of the prostate gland is extremely rare and only a few cases have been reported. There have been several cases of hemangioma of posterior urethra, urinary bladder and periprostatic plexus in the literature, all presenting with hematuria or hematospermia. Diagnosis of prostatic hemangio...... is difficult due to its rarity and unspecific symptoms such as hematuria, hematospermia or lower urinary tract symptoms. It cannot be detected by conventional examinations such as cystoscopy or standard rectal ultrasonography....

  6. Evaluation of liver hemangiomas using three different b values on diffusion MR

    Energy Technology Data Exchange (ETDEWEB)

    Bozgeyik, Zulkif, E-mail: bozgeyik4@hotmail.co [Department of Radiology, Faculty of Medicine, Firat University, 23119 Elazig (Turkey); Kocakoc, Ercan; Gul, Yeliz [Department of Radiology, Faculty of Medicine, Firat University, 23119 Elazig (Turkey); Dagli, A. Ferda [Department of Pathology, Faculty of Medicine, Firat University, 23119 Elazig (Turkey)

    2010-09-15

    Purpose: To determine which diffusion-weighted MR technique (i.e., b-100, b-600, b-1000 s/mm{sup 2}) is most useful in depicting liver hemangiomas. We also aimed to assess the effect of lesion size on apparent diffusion coefficient (ADC) values. Materials and methods: Diffusion-weighed MR (DWMR) was performed for 61 hemangiomas in 32 patients. DWMR images were obtained before contrast administration using three different b values of 100, 600, and 1000 s/mm{sup 2}. ADCs were measured for each lesions and compared with normal liver parenchymal ADCs on different b values. Hemangiomas were subdivided according to lesion size (less than 3 cm and 3 cm or greater). Data were analyzed using SPSS software by analysis of variances (ANOVA) and post hoc values were tested using HSD Tukey test. Results: There was no significant relation between lesion size and ADC values on different b values. Lower ADC values were obtained for higher b values in normal liver tissue and hemangiomas. Although there is significant difference between normal liver tissue and hemangiomas; this is more apparent on b-1000 images (p = 0.022 on b-100, p = 0.003 on b-600, and p = 0.000 on b-1000 images). Variance analysis revealed hemangiomas had higher ADC values than normal liver tissue on b-1000 images. Conclusion: Mean values for ADCs of hemangiomas were lower than ADCs of the normal liver except for b-1000 value. Higher b values are useful for the differentiation between normal liver tissue and hemangiomas. Lesion size does not affect ADC measurement on different b values.

  7. Laparoscopic treatment of a large pedunculated hemangioma of the liver: a case report

    Science.gov (United States)

    MELFA, G.; COCORULLO, G.; RASPANTI, C.; FALCO, N.; PORRELLO, C.; GULLO, R.; ROTOLO, G.; GENOVA, C.; GULOTTA, G.; SCERRINO, G.

    2016-01-01

    Hepatic hemangiomas are the most common benign tumors of the liver, often asymptomatic and discovered incidentally. A 62-year-old woman was referred to our Institution under the suspicion of having an 8 cm-sized GIST. Due to the atypical features of the lesion on TC scan, a biopsy was performed. We report the case of pedunculated hepatic hemangioma with the aim to discuss the diagnostic approach, the possible causes of misdiagnosis and the opportunity of the laparoscopic approach. PMID:27938533

  8. Spontaneous Rupture of a Giant Hepatic Hemangioma ? Sequential Management with Transcatheter Arterial Embolization and Resection

    OpenAIRE

    Jain Vaibhav; Ramachandran Vijay; Garg Rachana; Pal Sujoy; Gamanagatti Shivanand; Srivastava Deep

    2010-01-01

    Hemangioma is the most common benign tumor of liver and is often asymptomatic. Spontaneous rupture is rare but has a catastrophic outcome if not promptly managed. Emergent hepatic resection has been the treatment of choice but has high operative mortality. Preoperative transcatheter arterial embolization (TAE) can significantly improve outcome in such patients. We report a case of spontaneous rupture of giant hepatic hemangioma that presented with abdominal pain and shock due to hemoperitoneu...

  9. Giant Hepatic Hemangioma With Kasabach–Merritt Syndrome: Is the Appropriate Treatment Enucleation or Liver Transplantation?

    OpenAIRE

    Hochwald, Steven N.; Blumgart, Leslie H

    2000-01-01

    We present a case of giant cavernous hemangioma of the liver with disseminated intravascular coagulopathy (Kasabach–Merritt syndrome) which was cured by enucleation. The 51 year old woman presented with increased abdominal girth and easy bruisability. Workup elsewhere revealed a massive hepatic hemangioma and she was started on radiation therapy to the lesion and offered an orthotopic liver transplant. After careful preoperative preparation, we felt that resection w...

  10. [Spanish consensus on infantile haemangioma].

    Science.gov (United States)

    Baselga Torres, Eulalia; Bernabéu Wittel, José; van Esso Arbolave, Diego L; Febrer Bosch, María Isabel; Carrasco Sanz, Ángel; de Lucas Laguna, Raúl; Del Pozo Losada, Jesús; Hernández Martín, Ángela; Jiménez Montañés, Lorenzo; López Gutiérrez, Juan Carlos; Martín-Santiago, Ana; Redondo Bellón, Pedro; Ruíz-Canela Cáceres, Juan; Torrelo Fernández, Antonio; Vera Casaño, Ángel; Vicente Villa, María Asunción

    2016-11-01

    Infantile haemangiomas are benign tumours produced by the proliferation of endothelial cells of blood vessels, with a high incidence in children under the age of one year (4-10%). It is estimated that 12% of them require treatment. This treatment must be administered according to clinical practice guidelines, expert experience, patient characteristics and parent preferences. The consensus process was performed by using scientific evidence on the diagnosis and treatment of infantile haemangiomas, culled from a systematic review of the literature, together with specialist expert opinions. The recommendations issued were validated by the specialists, who also provided their level of agreement. This document contains recommendations on the classification, associations, complications, diagnosis, treatment, and follow-up of patients with infantile haemangioma. It also includes action algorithms, and addresses multidisciplinary management and referral criteria between the different specialities involved in the clinical management of this type of patient. The recommendations and the diagnostic and therapeutic algorithms of infantile haemangiomas contained in this document are a useful tool for the proper management of these patients. Copyright © 2015 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Infantile nystagmus and visual deprivation

    DEFF Research Database (Denmark)

    Fledelius, Hans C; Jensen, Hanne

    2014-01-01

    PURPOSE: To evaluate whether effects of early foveal motor instability due to infantile nystagmus might compare to those of experimental visual deprivation on refraction in a childhood series. METHODS: This was a retrospective analysis of data from the Danish Register for Blind and Weaksighted...

  12. Hepatic Hemangioma with Kasabach-Merritt Syndrome in an Adult Patient.

    Science.gov (United States)

    Oak, Chan Young; Jun, Chung Hwan; Cho, Eun Ae; Lee, Du Hyun; Cho, Sung Bum; Park, Chang Hwan; Joo, Young Eun; Kim, Hyun Soo; Rew, Jong Sun; Choi, Sung Kyu

    2016-04-25

    Hemangiomas are the most common benign tumors of the liver. They are generally asymptomatic, but giant hemangiomas can lead to abdominal discomfort, bleeding, or obstructive symptoms. Kasabach-Merritt syndrome is a rare but life-threatening complication of hemangioma, characterized by consumptive coagulopathy with large vascular tumors. More than 80% of Kasabach-Merritt syndrome cases occur within the first year of life. However, there are few reports of Kasabach-Merritt syndrome with giant hepatic hemangioma in adults and, as far as we know, no reports of Kasabach-Merritt syndrome with hepatic hemangioma treated with first line medical treatment only. The most important treatment for this syndrome is removal of the large vascular tumor. However, surgical treatment entails risk of bleeding, and the patient's condition can mitigate against surgery. We herein present a case of unresectable giant hepatic hemangioma with disseminated intravascular coagulopathy. The patient was a 60-year-old woman who complained of hematochezia, ecchymosis, and abdominal distension. She refused all surgical management and was therefore treated with systemic glucocorticoids and beta-blockers. After two weeks of steroid therapy, she responded partially to the treatment. Her laboratory findings and hematochezia improved. She was discharged on hospital day 33 and observed without signs of bleeding for three months.

  13. Diagnosis of hepatic hemangioma by parametric imaging using sonazoid-enhanced US.

    Science.gov (United States)

    Wakui, Noritaka; Takayama, Ryuji; Kamiyama, Naohisa; Takahashi, Masayoshi; Shiozawa, Kazue; Nagai, Hidenari; Watanabe, Manabu; Ishii, Koji; Iida, Kazunari; Igarashi, Yoshinori; Sumino, Yasukiyo

    2011-01-01

    Comparison of Parametric Imaging (PI) using Sonazoid-enhanced ultrasonography (US) and microflow imaging (MFI) to determine the possibility of hepatic hemangioma diagnosis using PI. Twenty-two hepatic hemangioma nodules (mean±SD diameter: 31.6±19.1mm) undergoing Sonazoid-enhanced US between February 2008 and March 2009. After Sonazoid-enhanced US, COMMUNE ultrasonographic image analysis software was used for analysis of tumor imaging dynamics in the vascular phase using PI and MFI. In PI, 0s was set as the time contrast agent reached the tumor. Imaging within the tumor after 0s was color-coded according to time, and the images were displayed in color. In MFI, 0s was set as the time contrast agent reached the tumor. The path of microbubbles as it flowed through blood vessels was superimposed on the original B-mode images. Three trained physicians used these methods to analyze tumor imaging dynamics. All physicians concluded all cases were hepatic hemangioma regardless of method used. However, compared to MFI, PI allowed determination of more detailed blood flow dynamics in high-flow hepatic hemangioma, where blood flow speed was faster than in normal hepatic hemangioma. It is possible to diagnose hepatic hemangioma using PI using sonazoid-enhanced US.

  14. Management of Giant Hepatic Hemangioma in Atypical Localization; Report of a Case and Literature Review.

    Science.gov (United States)

    Stankiewicz, Rafał; Kobryń, Konrad; Patkowski, Waldemar; Krawczyk, Marek

    2015-03-01

    Hemangiomas are the most common benign primary hepatic neoplasms, often being incidentally discovered. In most of the cases they are small and asymptomatic. It is widely accepted that clinical intervention is indicated only for symptomatic hemangiomas. We present a case of an asymptomatic giant hemangioma managed by enucleation due to its atypical localization. The hemangioma, originally located in segment 5, was now described in Computer Tomography (CT) Imaging as separating the gallbladder from the liver parenchyma. A careful evaluation of images revealed proximity to the portal vein (PV), right hepatic artery (RHA), right hepatic duct (RHD) and right branch of the portal vein (RBPV). Thus, in the case of an emergent operation, surgical maneuvers in the area of the altered hepatic anatomy and proximity to the hemangioma itself, would in fact increase the risk endangering the patient's life. After patient's consent, a surgical enucleation en block with the gall-bladder was performed. It is of great importance that specifically selected, asymptomatic patients diagnosed with a giant hemangioma, with the above mentioned or similar localization should be considered for surgical treatment.

  15. Rapamycin Inhibits Proliferation of Hemangioma Endothelial Cells by Reducing HIF-1-Dependent Expression of VEGF

    Science.gov (United States)

    Medici, Damian; Olsen, Bjorn R.

    2012-01-01

    Hemangiomas are tumors formed by hyper-proliferation of vascular endothelial cells. This is caused by elevated vascular endothelial growth factor (VEGF) signaling through VEGF receptor 2 (VEGFR2). Here we show that elevated VEGF levels produced by hemangioma endothelial cells are reduced by the mTOR inhibitor rapamycin. mTOR activates p70S6K, which controls translation of mRNA to generate proteins such as hypoxia inducible factor-1 (HIF-1). VEGF is a known HIF-1 target gene, and our data show that VEGF levels in hemangioma endothelial cells are reduced by HIF-1α siRNA. Over-expression of HIF-1α increases VEGF levels and endothelial cell proliferation. Furthermore, both rapamycin and HIF-1α siRNA reduce proliferation of hemangioma endothelial cells. These data suggest that mTOR and HIF-1 contribute to hemangioma endothelial cell proliferation by stimulating an autocrine loop of VEGF signaling. Furthermore, mTOR and HIF-1 may be therapeutic targets for the treatment of hemangiomas. PMID:22900063

  16. Preliminary Report On Combined Surgical- And Laser-Treatment Of Large Hemangiomas And Tattoos

    Science.gov (United States)

    Ginsbach, G.

    1981-05-01

    As most hemangiomas and tattoos require many sessions to be cured completely by argon-laser or conventional therapy I developed a new combined surgical and laser-therapy method for large hemangiomas and tattoos. This is a three step method. First: The skin lesion is treated by argon-laser with the point by point method, developed by ourself. Second: Under local or general anaesthesia a) the hemangioma is partially excised and undermined letting only the skin which is already treated by argon-laser-beams. Than the hemangioma is exstirpated in toto, the wound closed by running intradermal sutures and a pressure bandage applied, b) the tattoo is abraded as deep as possible, draped by lyofoam. Then a pressure bandage is applied. Third: The hemangioma as well as the tattoo are treated by argon-laser-beams after the operation. This method is safe and effective, gives good results, minimal scars in the case of hemangiomas and tattoos. In this paper the method is described and some cases are illustrated by pre- and postoperational photographs.

  17. Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF.

    Directory of Open Access Journals (Sweden)

    Damian Medici

    Full Text Available Hemangiomas are tumors formed by hyper-proliferation of vascular endothelial cells. This is caused by elevated vascular endothelial growth factor (VEGF signaling through VEGF receptor 2 (VEGFR2. Here we show that elevated VEGF levels produced by hemangioma endothelial cells are reduced by the mTOR inhibitor rapamycin. mTOR activates p70S6K, which controls translation of mRNA to generate proteins such as hypoxia inducible factor-1 (HIF-1. VEGF is a known HIF-1 target gene, and our data show that VEGF levels in hemangioma endothelial cells are reduced by HIF-1α siRNA. Over-expression of HIF-1α increases VEGF levels and endothelial cell proliferation. Furthermore, both rapamycin and HIF-1α siRNA reduce proliferation of hemangioma endothelial cells. These data suggest that mTOR and HIF-1 contribute to hemangioma endothelial cell proliferation by stimulating an autocrine loop of VEGF signaling. Furthermore, mTOR and HIF-1 may be therapeutic targets for the treatment of hemangiomas.

  18. Spontaneous rupture of a giant hepatic hemangioma. Sequential treatment with preoperative transcatheter arterial embolization and conservative hepatectomy.

    Science.gov (United States)

    Lupinacci, R M; Szejnfeld, D; Farah, J F M

    2011-01-01

    Hemangioma is the most common benign tumor of the liver and it is often asymptomatic. Spontaneous rupture of liver hemangiomas is a rare but potentially lethal complication. Emergent hepatic resection has been the treatment of choice but carries high operative morbidity and mortality. Recently, preoperative transcatheter arterial embolization (TAE) has been used successfully for the management of bleeding ruptured liver tumors and non-operative treatment of symptomatic giant liver hemangiomas. We report a case of spontaneous rupture of a giant hepatic hemangioma that presented with thoracic and abdominal pain and shock due to hemoperitoneum. Once proper diagnosis was made the patient was successfully managed by TAE, followed by conservative hepatic resection.

  19. Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms.

    Science.gov (United States)

    Chen, Y Z; Bai, N; Bi, J H; Liu, X W; Xu, G Q; Zhang, L F; Li, X Q; Huo, R

    2017-10-02

    The aim of this study was to investigate the mechanism of propranolol on the regression of hemangiomas. Propranolol-treated hemangioma tissues were collected and the expression of hypoxia inducible factor-1α (HIF-1α) was examined. We also established HIF-1α overexpression and knockdown hemangioma cells, and determined the effects of HIF-1α on the hemangioma cells proliferation, apoptosis, migration and tube formation. Significantly increased HIF-1α level was found in the hemangioma tissues compared to that in normal vascular tissues, whereas propranolol treatment decreased the HIF-1α level in hemangioma tissues in a time- and dose-dependent manner. Moreover, propranolol treatment significantly decreased cell proliferation, migration and tube formation as well as promoted cell apoptosis in HIF-1α overexpression and knockdown hemangioma cells. Propranolol suppressed the cells proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms. HIF-1α could serve as a novel target in the treatment of hemangiomas.

  20. Tratamento de hemangioma gigante com interferon alfa: relato de dois casos Treatment of giant hemangioma with interferon-alpha: report of two cases

    Directory of Open Access Journals (Sweden)

    Ana Julia Balau

    2007-12-01

    Full Text Available O objetivo do trabalho é descrever o uso de interferon alfa no tratamento de pacientes com hemangioma gigante. Os autores relatam e analisam dois casos de hemangioma gigante em tratamento com interferon alfa. IBS, 3 anos, em acompanhamento no Ambulatório de Hematologia desde um ano de idade com quadro de lesão angiomatosa em praticamente toda hemiface direita, acompanhada de sangramentos gengivais importantes. Após a realização de exames complementares (Angiorressonância magnética e feito o diagnóstico de hemangioma gigante em face, foi iniciado tratamento com prednisona e, posteriormente, associação com interferon alfa e observada importante melhora do quadro, resultando na diminuição dos episódios de sangramento e no tamanho do tumor. C.N.P., 12 anos, apresentando nódulo em região lateral de joelho esquerdo há 2 anos, com aumento progressivo do tamanho e dor local. Fez uso de prednisona e, sem melhora do quadro, introduzido interferon alfa com regressão importante do tamanho do tumor. O tratamento com interferon alfa deve ser considerado no tratamento de hemangiomas, pois apresenta bons resultados em relação à diminuição do tamanho do tumor e, conseqüentemente, reduz as intercorrências clínicas associadas à sua presença, principalmente os sangramentos.The aim of this study is to describe the treatment using interferon-alpha of giant hemangiomas in children. The authors report two cases of children presenting with giant hemangiomas treated using interferon-alpha and analyze the results. IBS, 3 years-old, has been followed up in Famema Hemathology Service since she was 1 year-old with a tumor on the face and persistent bleeding. After clinical and radiologic evaluations and suggested the diagnosis of giant hemangioma, she started treatment with interferon-alpha. A great clinical improvement was observed a reducing of the number of episodes of bleedings and a decrease in of the tumor size. CNP, 12 years-old, came to

  1. Diffuse cavernous hemangioma of the rectum: an atypical cause of rectal bleeding Hemangioma cavernoso difuso del recto: una causa atípica de hemorragia digestiva baja

    OpenAIRE

    D. Hervías; J. P. Turrión; Herrera, M.; J. Navajas León; R. Pajares Villarroya; N. Manceñido; Castillo, P.; Segura, J.M.

    2004-01-01

    Objective: cavernous hemangioma of the rectosigmoid colon is a rare disease, with no more than 200 cases reported in the literature. The rectosigmoid is the most common site of this disease in the gastrointestinal tract. Case report: we report the case of a 31-year-old male with recurrent episodes of rectal bleeding, who was finally diagnosed of diffuse cavernous hemangioma of the rectum. The tumor, of 12 x 10 x 9 cm in size, occupied the rectum to the margin of the anal sphincter. A surgical...

  2. Poland syndrome (anomaly with congenital hemangioma: A new association

    Directory of Open Access Journals (Sweden)

    Riyaz Najeeba

    2006-01-01

    Full Text Available Unilateral defect of pectoral muscle and ipsilateral syndactyly constitute Poland syndrome. Absence or hypoplasia of the breast and nipple, axillary hair loss and dermatoglyphic abnormalities have also been reported in this syndrome. The primary defect could be in the development of the proximal subclavian artery with early deficit of blood flow to the distal limb and the pectoral region, resulting in partial loss of tissue in those regions. However, the association of congenital hemangioma with Poland sequence has not been observed so far. Such an association is being reported here in a 1-year-old infant, second-born of nonconsanguineous parents, who also had polydactyly instead of the documented syndactyly.

  3. Concurrent hepatic adenomatoid tumor and hepatic hemangioma: a case report.

    Science.gov (United States)

    Kim, Ji-Beom; Yu, Eunsil; Shim, Ju-Hyun; Song, Gi-Won; Kim, Gwang Un; Jin, Young-Joo; Park, Ho-Seop

    2012-06-01

    A 45-year-old male with alleged asymptomatic hepatic hemangioma of 4 years duration had right upper-quadrant pain and was referred to a tertiary hospital. Computed tomography and magnetic resonance imaging scans revealed a hypervascular mass of about 7 cm containing intratumoral multilobulated cysts. A preoperative liver biopsy was performed, but this failed to provide a definitive diagnosis. The patient underwent a partial hepatectomy of segments IV and VIII. The histologic findings revealed multifocal proliferation of flattened or cuboidal epithelioid cells and a highly vascular edematous stroma. Immunohistochemistry findings demonstrated that the epithelioid tumor cells were positive for cytokeratin (AE1/AE3), vimentin, calretinin, and cytokeratin 5/6, and were focally positive for CD10, and negative for WT1 and CD34, all of which support their mesothelial origin. Immunohistochemistry for a mesothelial marker should be performed for determining the presence of an adenomatoid tumor when benign epithelioid cells are seen.

  4. Concurrent hepatic adenomatoid tumor and hepatic hemangioma: a case report

    Directory of Open Access Journals (Sweden)

    Ji-Beom Kim

    2012-06-01

    Full Text Available A 45-year-old male with alleged asymptomatic hepatic hemangioma of 4 years duration had right upper-quadrant pain and was referred to a tertiary hospital. Computed tomography and magnetic resonance imaging scans revealed a hypervascular mass of about 7 cm containing intratumoral multilobulated cysts. A preoperative liver biopsy was performed, but this failed to provide a definitive diagnosis. The patient underwent a partial hepatectomy of segments IV and VIII. The histologic findings revealed multifocal proliferation of flattened or cuboidal epithelioid cells and a highly vascular edematous stroma. Immunohistochemistry findings demonstrated that the epithelioid tumor cells were positive for cytokeratin (AE1/AE3, vimentin, calretinin, and cytokeratin 5/6, and were focally positive for CD10, and negative for WT1 and CD34, all of which support their mesothelial origin. Immunohistochemistry for a mesothelial marker should be performed for determining the presence of an adenomatoid tumor when benign epithelioid cells are seen.

  5. Congenital arteriovenous fistula of the horseshoe kidney with multiple hemangiomas

    Directory of Open Access Journals (Sweden)

    Lazić Miodrag

    2012-01-01

    Full Text Available Introduction. Congenital renal arteriovenous fistulas (AVF are rare, especially if they are associated with other developmental renal anomalies. Case Outline. A 34-year-old female was hospitalized due to total painless hematuria and bladder tamponade. Excretory urography revealed a horseshoe kidney with normal morphology of pyelocaliceal system and ureters. Aortography and selective renovasography detected a cluster-like vascular formation with multiple arteriovenous fistulas (AVF. Due to a large AVF gauge and poor flow of the efferent vein to the inferior vena cava, a surgical procedure of two renal artery segmentary branches ligation and division was performed. During the operative procedure, the presence of multiple superficial renal hemangiomas was detected. Conclusion. Although selective arterial embolization represents the preferable treatment option, conventional surgery remains favorable alternative in selected cases with large and complex AVF.

  6. Bilateral ovarian capillary hemangioma with stromal luteinization and hyperandrogenism.

    Science.gov (United States)

    Huang, Richard Sheng Poe; Covinsky, Michael; Zhang, Songlin

    2013-01-01

    A 77-year-old female presented to the outpatient clinic with a six-month history of left lower quadrant abdominal fullness and pressure. Serum levels included free testosterone 3.8 pg/mL (normal 0-1.8 pg/mL) and testosterone 259 ng/dL (normal 3-41 ng/dL). Magnetic resonance imaging of the pelvis showed bilateral small ovarian cystic masses with marked, progressive enhancement, and restriction of diffusion. Laparoscopic bilateral salpingo-oophorectomy was performed and showed left and right ovarian hemorrhagic masses measuring 2.1 cm and 0.6 cm respectively. The histology showed benign vascular lesions composed of small capillary vessels with a rim of luteinized stromal cells. The luteinized cells were strongly positive for inhibin A. The endothelial cells were negative for estrogen receptor and progesterone receptor. To our knowledge, this is the first reported case of bilateral ovarian hemangioma with stromal luteinization and hyperandrogenism.

  7. Neonatal and infantile acne vulgaris: an update.

    Science.gov (United States)

    Serna-Tamayo, Cristian; Janniger, Camila K; Micali, Giuseppe; Schwartz, Robert A

    2014-07-01

    Acne may present in neonates, infants, and small children. Neonatal and infantile acne vulgaris are not considered to be rare. The presentation of acne in this patient population sometimes represents virilization and may portend later development of severe adolescent acne. Neonatal and infantile acne vulgaris must be distinguished from other cutaneous disorders seen in newborns and infants. Infantile acne tends to be more pleomorphic and inflammatory, thus requiring more vigorous therapy than neonatal acne.

  8. Genetics Home Reference: infantile neuroaxonal dystrophy

    Science.gov (United States)

    ... optic nerve) often occur in infantile neuroaxonal dystrophy . Hearing loss may also develop. Children with this disorder experience progressive deterioration of cognitive functions (dementia), and ...

  9. Infantile masturbation and paroxysmal disorders.

    Science.gov (United States)

    Omran, Mohammadreza Salehi; Ghofrani, Mohammad; Juibary, Ali Ghabeli

    2008-02-01

    A recurrent paroxysmal presentation in children leads to different diagnoses and among them are neurologic and cardiac etiologies. Infantile masturbation is not a well known entity and cannot be differentiated easily from other disorders. Aim of this study is to elucidate and differentiate this condition from epileptic seizures. We report 3 cases of 10 to 30 mth old girls of infantile masturbation that their symptoms initiated at 2, 3 and 8 mth of age. These present with contraction and extension of lower extremities, scissoring of legs, perspiration, changing face color. In 2 cases body rocking and legs rubbing initiated then there after. Masturbation is one of the paroxysmal non-epileptic conditions of early infancy and is in differential diagnosis of epileptic seizures.

  10. Severe progressive scoliosis due to huge subcutaneous cavernous hemangioma: A case report

    Directory of Open Access Journals (Sweden)

    Toyama Yoshiaki

    2011-03-01

    Full Text Available Abstract Cavernous hemangioma consists mainly of congenital vascular malformations present before birth and gradually increasing in size with skeletal growth. A small number of patients with cavernous hemangioma develop scoliosis, and surgical treatment for the scoliosis in such cases has not been reported to date. Here we report a 12-year-old male patient with severe progressive scoliosis due to a huge subcutaneous cavernous hemangioma, who underwent posterior correction and fusion surgery. Upon referral to our department, radiographs revealed a scoliosis of 85° at T6-L1 and a kyphosis of 58° at T4-T10. CT and MR images revealed a huge hemangioma extending from the subcutaneous region to the paraspinal muscles and the retroperitoneal space and invading the spinal canal. Posterior correction and fusion surgery using pedicle screws between T2 and L3 were performed. Massive hemorrhage from the hemangioma occurred during the surgery, with intraoperative blood loss reaching 2800 ml. The scoliosis was corrected to 59°, and the kyphosis to 45° after surgery. Seven hours after surgery, the patient suffered from hypovolemic shock and disseminated intravascular coagulation due to postoperative hemorrhage from the hemangioma. The patient developed sensory and conduction aphasia caused by cerebral hypoxia during the shock on the day of the surgery. At present, two years after the surgery, although the patient has completely recovered from the aphasia. This case illustrates that, in correction surgery for scoliosis due to huge subcutaneous cavernous hemangioma, intraoperative and postoperative intensive care for hemodynamics should be performed, since massive hemorrhage can occur during the postoperative period as well as the intraoperative period.

  11. Myofibromatose infantile infratemporale | Omezzine | Journal ...

    African Journals Online (AJOL)

    La myofibromatose infantile est une affection proliférative mésenchymateuse rare de l'enfance (1 / 400 000). Ce processus tumoral bénin peut intéresser les tissus mous, les muscles, l'os et rarement les viscères. elle peut se présenter sous une forme solitaire ou multicentrique. La localisation cervico-faciale intéresse 30% ...

  12. Infantile spasms: A prognostic evaluation.

    Science.gov (United States)

    Iype, Mary; Saradakutty, Geetha; Kunju, Puthuvathra Abdul Mohammed; Mohan, Devi; Nair, Muttathu Krishnapanicker Chandrasekharan; George, Babu; Ahamed, Shahanaz M

    2016-01-01

    Few papers address the comprehensive prognosis in infantile spasms and look into the seizure profile and psychomotor outcome. We aimed to follow up children with infantile spasms to study: a) the etiology, demographics, semiology, electroencephalogram (EEG), and radiological pattern; b) seizure control, psychomotor development, and EEG resolution with treatment; c) the effects of various factors on the control of spasms, resolution of EEG changes, and psychomotor development at 3-year follow-up. Fifty newly diagnosed cases with a 1-12 month age of onset and who had hypsarrhythmia in their EEG were recruited and 43 were followed up for 3 years. Of the children followed up, 51% were seizure-free and 37% had a normal EEG at the 3-year follow-up. Autistic features were seen in 74% of the children. Only 22.7% among the seizure-free (11.6% of the total) children had normal vision and hearing, speech with narration, writing skills, gross and fine motor development, and no autism or hyperactivity. On multivariate analysis, two factors could predict bad seizure outcome - the occurrence of other seizures in addition to infantile spasms and no response to 28 days of adrenocorticotropic hormone (ACTH). No predictor could be identified for abnormal psychomotor development. In our study, we could demonstrate two factors that predict seizure freedom. The cognitive outcome and seizure control in this group of children are comparable to the existing literature. However, the cognitive outcome revealed by our study and the survey of the literature are discouraging.

  13. Hemangioma hepático gigante asociado a síndrome de Kasabach-Merrit Giant hepatic hemangioma associated with Hodgkin's lymphoma

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    M. Valdés Mas

    2008-08-01

    Full Text Available El hemangioma hepático es el tumor benigno más frecuente del hígado. La gran mayoría de ellos son de pequeño tamaño, asintomáticos y con un pronóstico excelente. En raras ocasiones son de mayor tamaño y pueden estar asociados a una coagulopatía de consumo denominada síndrome de Kasabach-Merrit. Presentamos el caso de un paciente varón joven con un hemangioma hepático gigante y hemangiomatosis múltiple asociado al síndrome de Kasabach-Merrit.Hepatic hemangioma is the most frequent liver's tumor. The majority are small, asymptomatic and have an excellent prognosis. Those larger than 5 cm can be associated to a consumptive coagulopathy called Kasabach-Merrit syndrome. We present a patient with a giant hepatic hemangioma with multiple hemangimatosis associated to Kasabach-Merrit syndrome.

  14. Quantitative study of signal intensity in hepatic hemangioma: a new parameter in high field magnetic resonance; Estudo quantitativo da intensidade de sinal do hemangioma hepatico: um novo parametro utilizado em ressonancia magnetica de alto campo

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    D`Ippolito, Giuseppe; Tiferes, Dario Ariel [Escola Paulista de Medicina, Sao Paulo, SP (Brazil)

    1995-05-01

    Prospective study of morphologic and quantitative parameters of hepatic hemangiomas in high field magnetic resonance, establishing their isolated efficacy and the best sequence for high diagnostic accuracy. Sixteen hepatic hemangiomas were examined in spin-echo and multiecho sequences. The morphologic aspects of the lesion were analyzed and lesion /liver signal intensity ratio was computed. Results showed that, although high field magnetic resonance is highly sensible in the detection of hepatic hemangiomas (94%), the great variety of appearances may cause diagnostic doubts (66.7% of atypic hemangiomas) when morphologic parameters are used only. On the other hand, the exclusive use of lesion/liver intensity ratio suggested the diagnosis of hemangioma in all cases. (author). 30 refs., 3 figs., 4 tabs.

  15. Hemangioma of uterine cervix associated with high-grade squamous intraepithelial lesion

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    Đolai Matilda

    2015-01-01

    Full Text Available Introduction. Benign, especially polypoid, lesions of the cervix are common in everyday work. Rare tumors of this region are vascular ones, particularly capillary and/or cavernous hemangiomas. Cervical hemangiomas are especially rare, usually asymptomatic and only one third of the cases is clinically manifested as vaginal bleeding, polyps, etc. Case report. We reported a 54-year-old postmenopausal female patient who had undergone conization due to high-grade squamous intra-epithelial lesion (H-SIL. Microscopic analysis of slices confirmed the existence of dysplastic changes in the endocervical epithelium and in small part in the epithelium of the gland of H-SIL type. In 2 of 15 slices, within the walls of the cervix, dilated, amplified and abnormal blood vessels lined with endothelium were observed, vaguely limited by the surrounding connective tissue of lamina propria and smooth muscle wall of the cervix. According to the pathological characteristics, the change corresponded to the hemangioma. Both changes were completely removed. Conclusion. In comparison with the available literature data, the presented case is the first to describe the association of hemangioma and dysplastic changes in the endocervical epithelium. Hemangioma was incidentally discovered in the histological sections of the material after the conization in a postmenopausal women.

  16. Laser therapy and sclerotherapy in the treatment of oral and maxillofacial hemangioma and vascular malformations

    Science.gov (United States)

    Crişan, Bogdan; BǎciuÅ£, Mihaela; BǎciuÅ£, Grigore; Crişan, Liana; Bran, Simion; Rotar, Horatiu; Moldovan, Iuliu; Vǎcǎraş, Sergiu; Mitre, Ileana; Barbur, Ioan; Magdaş, Andreea; Dinu, Cristian

    2016-03-01

    Hemangioma and vascular malformations in the field of oral and maxillofacial surgery is a pathology more often found in recent years in patients. The aim of this study was to evaluate the efficacy of the laser photocoagulation performed with a diode laser (Ga-Al-As) 980 nm wavelength in the treatment of vascular lesions which are located on the oral and maxillofacial areas, using color Doppler ultrasonography for evaluation of the results. We also made a comparison between laser therapy and sclerotherapy in order to establish treatment protocols and recommendations associated with this pathology. We conducted a controlled study on a group of 92 patients (38 male and 54 female patients, with an average age of 36 years) having low flow hemangioma and vascular malformations. Patients in this trial received one of the methods of treatment for vascular lesions such as hemangioma and vascular malformations: laser therapy or sclerotherapy. After laser therapy we have achieved a reduction in size of hemangioma and vascular malformations treated with such a procedure, and the aesthetic results were favorable. No reperfusion or recanalization of laser treated vascular lesions was observed after an average follow-up of 6 to 12 months. In case of sclerotherapy a reduction in the size of vascular lesions was also obtained. The 980 nm diode laser has been proved to be an effective tool in the treatment of hemangioma and vascular malformations in oral and maxillofacial area. Laser therapy in the treatment of vascular lesions was more effective than the sclerotherapy procedure.

  17. The significance of echogenic rim of atypical hepatic hemangioma on ultrasonogram

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    Lee, Choon Hyeong; Ko, Young Tae; Lee, Dong Ho; Lim, Joo Won; Yoon, Yup [Kyunghee Univ. Hospital, Seoul (Korea, Republic of)

    1996-11-01

    To evaluate whether the presence of a peripheral echogenic rim surrounding internal low echogenicity is helpful in the diagnosis of atypical hepatic hemangioma. Within a two-year period, a retrospective review of the sonographic appearances of 24 atypical hemangiomas in 21 patients was performed. Diagnosis was made by dynamic and delayed enhanced CT, MR imaging or clinical follow up for one year, including follow-up sonogram. The sonographic appearances of these hemangiomas were analyzed for pattern and thickness of the echogenic rim, internal echo pattern, shape, and size. Additionally, forty six lesions of hepatoma, metastasis, abscess and intrahepatic cholangiocarcinoma confirmed by pathology within the same period were also evaluated for the presence of echogenic rim. Twenty-three of 24 lesions showed an echogenic rim;these were thick in nine cases, and thin in 14 cases. The thickness of the rim was either uniform(n=10) or eccentric(n=13). The average maximum diameter of atypical hemangioma was 4.4cm(range of diameters, 1.5-12cm). The internal echo pattern was partially or entirely hypoechoic in 15 lesions, homogeneously isoechoic in three, and mixed in six cases. Twenty-one lesions were round, and the shape of three was irregular. The other forty six masses including hepatocellular carcinoma, metastases, cholangiocarcinoma and hepatic abscesses did not show an echogenic rim. The presence of a sonographic echogenic rim in a hepatic mass may help in the diagnosis of hepatic hemangioma.

  18. CT findings of increased attenuation of the liver adjacent to the hemangioma

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    Yoon, Suk Kwon; Yang, Dal Mo; Yoon, Myung Hwan; Kim, Hak Soo; Koh, Sung Hye; O, Eun Young; Kim, Hyung Sik; Chung, Jin Woo [Gachon Medical College, Gil Medical Center, Seoul (Korea, Republic of)

    1999-05-01

    The purpose of this study was to evaluate the frequency, location, and appearance of increased attenuation of the liver adjacent to a mass during arterial-phase spiral CT in patients with hemangioma. The characteristics of the mass associated with these findings were also evaluated. Using spiral CT, 153 lesions in 114 hepatic hemangioma patients were retrospectively reviewed. We evaluated the frequency, location, and appearance of increased hepatic attenuation adjacent to the hemangioma, and determined whether lesion size varied according to whether or not there was increased hepatic attenuation. Areas of increased hepatic attenuation adjacent to the hemangioma were identified in 10.5% of cases(16/153) and seen in masses which showed a homogeneously hyperdense (11/16, 69%) or peripherally hyperdense pattern (5/16, 31%). The location of increased hepatic attenuation was commonly the peripheral portion (9/16, 56%), and increased hepatic attenuation was frequently wedge shaped of the mass (11/16, 69%). Lesion size did not vary according to whether or not there was increased hepatic attenuation. Increased hepatic attenuation adjacent to a hemangioma is not rare, and is usually located peripheral to the mass. It is common in a mass showing a homogeneously hyperdense pattern.

  19. Painful hepatic hemangioma: report of a case with an emphasis on sonographic findings.

    Science.gov (United States)

    Kato, Ryusuke; Ishida, Hideaki; Yagisawa, Hitoshi; Ishii, Toru; Komatsuda, Tomoya; Miyauchi, Takaharu; Sato, Tsutomu; Saito, Ken

    2010-01-01

    Hepatic hemangiomas are usually asymptomatic and very rarely produce abdominal symptoms. We report a painful 10 × 9 cm hemangioma situated at the hepatic surface of segment 6. The lesion showed a heterogeneous internal structure, composed irregularly of hyperechoic and hypoechoic areas, and it also showed weak posterior echo enhancement. Contrast-enhanced US showed the so-called fill-in pattern, leading to the diagnosis of hepatic hemangioma. The patient's abdomen showed no other abnormal findings, which stressed the relationship between the hemangioma and the patient's symptoms. When the diagnosis of hepatic hemangioma is conclusive, surgical therapy is indicated only in patients with severe symptoms. Our patient was considered to be a candidate for enucleation of the lesion. Histopathologically, the lesion included no areas of hemorrhage or necrosis, and the patient's abdominal pain was likely due to distension of the liver capsule. After surgery, the patient was completely free of symptoms, and enucleation was considered to be appropriate.

  20. Dynamic MR imaging of hepatic hemangioma and hepatocellular: findings and differential diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Seon Hee; Kim, Sook Young; Choi, Seok Jin; Song, Dong Hoon; Cha, Seong Sook; Eun, Tchoong Kie [Pusan Paik Hospital, College of Medicine, Inje University, Busan (Korea, Republic of)

    1994-01-15

    We performed dynamic MR imaging using Gd-DTPA to find characteristic enhancement pattern of hepatic hemangioma distinguishing from hepatocellular carcinoma. 28 hepatic hemangiomas and 10 hepatocellular carcinomas were evaluated. Serial dynamic scans after Gd-DTPA(0.1m mol/kg) intravenous injection were obtained by using 0.5T machine and analyzed contrast-to-noise ratio(CNR) of the lesion and enhancement pattern on each scan. Hepatic hemangiomas had positive CNR from 1-2 minute images, and revealed typical 'fill-in phenomenon' on early phase with prolonged enhancement in 26 cases(92.8%), and early homogeneous enhancement with isointensity on delayed phase in 2 cases(7.2%) of small hemangioma. Hepatocellular carcinomas revealed inhomogeneous enhancement with hypointensity on delayed phase in 10 cases(100%) and 3 cases (30%) of capsular enhancement. Hepatic hemangioma can be easily distinguished from hepatocellular carcinoma by using Gd-DTPA enhanced dynamic MR imaging according to its typical enhancement pattern of 'fill-in phenomenon' and prolonged enhancement.

  1. A creative therapy in treating cavernous hemangioma of penis with copper wire.

    Science.gov (United States)

    Zhang, Dong; Zhang, Haiyang; Sun, Peng; Li, Peng; Xue, Aibing; Jin, Xunbo

    2014-10-01

    Cavernous hemangiomas of penis are rare benign lesions infrequently described in the literature. No completely satisfactory treatment has been found to correct the cosmetic deformities especially the extensive hemangiomas of corpus penis. In light of the promising application of copper wire/needle in vascular malformations, we began a clinical study to investigate the safety, feasibility, and cosmetic effect of copper wire therapy in treating cavernous hemangioma of penis. Seven patients ranging in age from 12 to 32 years with penile cavernous hemangiomas entered our study from 2005 to 2011. All patients received treatments with percutaneous copper wires. Perioperative data including mean operation time, estimated blood loss, length of copper wire retention, and length of hospital stay were analyzed. All possible complications were noted, and cosmetic result was evaluated. Patients were followed up after discharge from the hospital. All operations were successful, and no obvious complications were observed. The patients were satisfied with the aesthetic results. Follow-up time ranged from 1 to 5 years. Recurrence was discovered in a patient with the largest lesion of corpus penis 2 months after the treatment. Secondary procedure was carried out with the same technique, and no lesions were found later. The shortage of studies on this topic prevented us from defining a therapeutic reference standard. The results of our study confirmed that copper wire therapy was a simple, safe, and useful option for penile cavernous hemangioma. © 2013 International Society for Sexual Medicine.

  2. Living-donor liver transplantation for giant hepatic hemangioma with diffuse hemangiomatosis in an adult: a case report.

    Science.gov (United States)

    Lee, Ju Hyun; Yoon, Chang Jin; Kim, Young Hoon; Han, Ho-Seong; Cho, Jai Young; Cho, Jai Young; Kim, Haeryoung; Jang, Eun Sun; Kim, Jin-Wook; Jeong, Sook-Hyang

    2017-07-19

    Hepatic hemangioma represents the most common benign primary hepatic neoplasm. Although most such tumors are small and asymptomatic, giant hepatic hemangioma is frequently symptomatic, and requires intervention. Moreover, diffuse multiple hepatic hemangiomatosis occupying almost the entire liver is extremely rare in adults, and the optimal management for this condition is unclear. We report a case of a rapidly growing, symptomatic giant hepatic hemangioma with diffuse hepatic hemangiomatosis in a 50-year-old female patient who was treated by living-donor liver transplantation. This case shows malignant behavior of a benign hemangioma that required liver transplantation. Although this case could not meet the criteria for transplantation according to the MELD (model for end-stage liver disease) score system, it should be considered as an exceptional indication for deceased-donor liver allocation. Further studies of the mechanism underlying hemangioma growth are warranted.

  3. Prospective study of ultrasound with perflutrene contrast compared to magnetic resonance imaging in the diagnosis of hepatic hemangiomas

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    Joel Schmillevitch

    2011-06-01

    Full Text Available CONTEXT:The incidence of hepatic hemangiomas ranges from 0.4% to 20% in the general population. Conventional ultrasound is usually the first diagnostic method to identify these hemangiomas, typically as an incidental finding. Ultrasonography with second generation contrast materials is being used in various areas of hepatology, yielding similar results to those obtained with computerized tomography and magnetic resonance imaging in the diagnosis of hepatic hemangiomas. OBJECTIVE: To evaluate the agreement between ultrasound with perflutrene contrast and magnetic resonance imaging in the diagnosis of hepatic hemangiomas. METHODS: A total of 37 patients were prospectively examined between January 2006 and August 2008. A total of 57 hepatic nodules were documented in this group as incidental findings on routine ultrasound exams. The 37 patients were administered perflutrene contrast without adverse reactions, and were all submitted to magnetic resonance exams. RESULTS: Conventional ultrasound identified 15 patients with nodules typical of hemangiomas and 22 patients with other nodules. In 35 patients, the contrast characteristics were consistent with hepatic hemangiomas. CONCLUSION: Agreement between the data obtained from ultrasound with contrast and magnetic resonance was 94.5%. In discordant cases, the magnetic resonance diagnosis prevailed. In the case which presented indeterminate findings on contrast ultrasonography, magnetic resonance was repeated after 3 months, confirming the diagnosis of a hepatic hemangioma. A biopsy was performed on the suspected malignant nodule which also confirmed the presence of a hepatic hemangioma. Ultrasonography with contrast has the advantages of being more accessible to the public at large and lower cost than magnetic resonance. The results of our study highlight the need for a new protocol in hepatic nodules incidentally identified on conventional ultrasonography. In the case of typical hemangiomas

  4. Birth Weight, Gestational Age, and Infantile Colic

    DEFF Research Database (Denmark)

    Milidou, Ioanna; Søndregaard, Charlotte; Jensen, Morten Søndergaard

    Background Infantile colic is a condition of unknown origin characterized by paroxysms of crying during the first months of life. A few studies have identified low birth weight (BW) as a risk factor among infants born at term, while the association between gestational age (GA) and infantile colic...... has not been studied. Aim We aimed to investigate the association between BW, GA, and infantile colic. Methods We studied 62,785 singletons enrolled in the Danish National Birth Cohort. Information on infantile colic symptoms and possible confounders was collected by computer-assisted telephone...... interviews of the mother during pregnancy and post partum. Adjusted odds ratios (OR) with 95% confidence intervals (in brackets) are presented. Infantile colic was defined as crying for more than three hours per day and for more than three days per week (modified Wessel’s criteria). Results A total of 4...

  5. Polysomnographic findings in infantile Pompe disease.

    Science.gov (United States)

    Kansagra, Sujay; Austin, Stephanie; DeArmey, Stephanie; Kishnani, Priya S; Kravitz, Richard M

    2013-12-01

    Infantile Pompe disease is a rare, autosomal recessive disorder due to deficiency of the enzyme acid α-glucosidase that degrades lysosomal glycogen. Clinical features of diffuse hypotonia, cardiomyopathy, and weakness are present within the first days to months of life in patients with classic infantile Pompe disease. Progression of the disease often leads to respiratory failure. Although sleep apnea is reported in late-onset Pompe disease, sleep pathology is not well characterized in infantile disease. In this retrospective study, we analyzed nocturnal polysomnography results from 17 patients with infantile-onset Pompe disease. Obstructive sleep apnea and hypoventilation were common among this cohort, even in those that did not have symptoms of sleep-disordered breathing. All patients with infantile-onset Pompe disease should undergo polysomnography as a routine part of their care. © 2013 Wiley Periodicals, Inc.

  6. A primary cavernous hemangioma of the thyroid gland: A case report and literature review.

    Science.gov (United States)

    Miao, Jie; Chen, Shubo; Li, Yongcai; Fu, Lin; Li, Hui

    2017-12-01

    Thyroid hemangioma is benign and associated with fine-needle aspiration (FNA) biopsy or trauma in most cases. Its differential diagnosis is very difficult. We presented the case of a 48-year-old man complained of slowly progressed swelling in the anterior neck for 20 years. Ultrasound and CT scan revealed a hypoechogenic and heterogeneous mass measuring 4 × 3.5 cm located in the right lobe of thyroid gland. Postoperative pathological and immunohistochemical examinations of the surgical specimen revealed a primary hemangioma of the thyroid gland. The patient received a right lobectomy of the thyroid. The patient had been followed up for 10 months after surgery without complications and remained asymptomatic. Primary thyroid hemangioma should be considered when there is a well-circumscribed capsule mass on medical imaging without history of FNA or any other cervical procedures or trauma.

  7. Scintigraphic diagnosis of hepatic hemangioma: its role in the management of hepatic mass lesions

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    Moinuddin, M.; Allison, J.R.; Montgomery, J.H.; Rockett, J.F.; McMurray, J.M.

    1985-08-01

    Hepatic cavernous hemangiomas are benign tumors of the liver that are often an incidental finding. They are usually asymptomatic but may cause symptoms when traumatized, may bleed spontaneously, or may produce pain by virtue of their large size and mass effect. A retrospective analysis of the clinical presentation, liver function tests, and diagnostic imaging procedures in 20 patients with hepatic hemangiomas is presented and the literature is reviewed. The 20 patients had 27 mass lesions as seen on liver scintigraphy, computed tomography, or sonography. Technetium-99m-labeled red blood cell flow studies and blood pool scintigrams showed delayed filling of the mass lesions, diagnostic of hemangiomas. This finding was not encountered in any other type of lesion. A new diagnostic algorithm is proposed in which flood-flow and blood-pool scintigraphy play a more prominent role in the diagnostic workup.

  8. Giant Hepatic Hemangioma With Kasabach–Merritt Syndrome: Is the Appropriate Treatment Enucleation or Liver Transplantation?

    Science.gov (United States)

    Hochwald, Steven N.

    2000-01-01

    We present a case of giant cavernous hemangioma of the liver with disseminated intravascular coagulopathy (Kasabach–Merritt syndrome) which was cured by enucleation. The 51 year old woman presented with increased abdominal girth and easy bruisability. Workup elsewhere revealed a massive hepatic hemangioma and she was started on radiation therapy to the lesion and offered an orthotopic liver transplant. After careful preoperative preparation, we felt that resection was possible and she underwent a successful enucleation. The operation and postoperative course were complicated by bleeding but she recovered and remains well in followup after 6 months. All coagulation parameters have returned to normal. Enucleation should be considered the treatment of choice for hepatic hemangiomas, including those presenting with Kasabach–Merritt syndrome. The benefits of enucleation as compared to liver transplantation for these lesions are discussed. PMID:10977121

  9. Marked enlargement and post-op recurrence of hepatic hemangiomas : two cases report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Woon; Chang, Jay Chun; Cho, Jae Ho; Park, Bok Hwan; Kim, Hong Jin; Kwun, Koing Bo [Yeungnam University, Taegu (Korea, Republic of). Coll. of Medicine

    1998-05-01

    Hepatic hemangiomas are the most common benign tumor of the liver, and follow-up radiologic imaging studies have normally shown no interval change in the diameter of the tumor. Among the very few tumors in which such change have been seen, growth has been minimal. However, we experienced some marked enlargement of the tumor follow-up imaging studies. First, the marked enlargement of the tumor followed by resection, and as a result, hepatic hemangioma was confirmed. Second, hepatic hemangioma was confirmed after resection, but recurred. Tumor enlargement seems to be caused by ectasia of blood-filled cystic space or estrogen stimulation, through we found no specific etiology. (author). 10 refs., 4 figs.

  10. Hepatic hemangioma: contrast enhancement patterns on two-phase spiral CT

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    Yun, Eun Joo; Choi, Byung Ihn; Han, Joon Koo; Jang, Hyun Jung; Kim, Tae Kyoung; Kim, Ah Young; Lee, Ki Yeol [Seoul National Univ., Seoul (Korea, Republic of). Coll. of Medicine

    1998-01-01

    To evaluate contrast enhancement patterns of hemangioma according to size, as seen during the arterial and portal venous phase of spiral CT. Overall, the most common enhancement pattern was peripheral high (44/82, 53.7%), during the arterial and portal venous phase. The second and third most common patterns were uniform high (11/82, 13.4%) and peripheral high-uniform high (9/82, 11.0%), also during the arterial and portal venous phase. In tumors smaller than 20 mm, low-low attenuation was seen in eight (9.8%), and iso-low attenuation in two (2.4%), during the arterial and portal venous phase, respectively. On two-phase spiral CT, the most common enhancement pattern of hemangioma was peripheral high, seen during the arterial and portal venous phase. However, a small hemangioma less than 2cm may show atypical patterns, including low and iso attenuation. (author). 23 refs., 1 tab., 4 figs.

  11. Epithelioid hemangioma of the penis: case report and review of literature

    Directory of Open Access Journals (Sweden)

    Freeman Alex

    2011-06-01

    Full Text Available Abstract Introduction Epithelioid hemangioma is a rare vascular tumor found in the penis. It is essential to avoid misdiagnosis with Peyronie's disease and penile cancer, as management differs significantly. Case presentation We present a case of epithelioid hemangioma of the penis in a 50-year-old Caucasian man. We also review the literature to evaluate the incidence of benign vascular anomalies of the penis and their management. Conclusions Epithelioid hemangioma of the penis should be considered in the differential diagnosis of patients presenting with painful penile lumps. A thorough histological and immunohistochemical examination is required to make the diagnosis. Optimal management is complete local excision and periodic physical examination for local recurrence.

  12. Co-occurrence of intraoral hemangioma and port wine stain: A rare case

    Directory of Open Access Journals (Sweden)

    Prasanna Kumar Rao

    2012-01-01

    Full Text Available Hemangiomas are neoplastic proliferations of endothelial cells, characterized by a period of growth after birth, and eventual spontaneous involution. The course can be uneventful with spontaneous resolution; or it may be marked by complications such as infection, bleeding, ulceration, visual defects and feeding difficulties. Apart from these, rare life-threatening complications such as congestive heart failure and consumption coagulopathy may also be seen. Although hemangiomas commonly occur in the head and neck region, intraoral occurrence is relatively rare. A port wine stain is defined as a macular telangiectatic patch which is present at birth and remains throughout life. They may be localized or extensive, affecting a whole limb. This article reports a rare case of co-occurrence of port wine stain with intraoral hemangioma.

  13. Infantile spasms: A prognostic evaluation

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    Mary Iype

    2016-01-01

    Full Text Available Background: Few papers address the comprehensive prognosis in infantile spasms and look into the seizure profile and psychomotor outcome. Objective: We aimed to follow up children with infantile spasms to study: a the etiology, demographics, semiology, electroencephalogram (EEG, and radiological pattern; b seizure control, psychomotor development, and EEG resolution with treatment; c the effects of various factors on the control of spasms, resolution of EEG changes, and psychomotor development at 3-year follow-up. Materials and Methods: Fifty newly diagnosed cases with a 1-12 month age of onset and who had hypsarrhythmia in their EEG were recruited and 43 were followed up for 3 years. Results: Of the children followed up, 51% were seizure-free and 37% had a normal EEG at the 3-year follow-up. Autistic features were seen in 74% of the children. Only 22.7% among the seizure-free (11.6% of the total children had normal vision and hearing, speech with narration, writing skills, gross and fine motor development, and no autism or hyperactivity. On multivariate analysis, two factors could predict bad seizure outcome — the occurrence of other seizures in addition to infantile spasms and no response to 28 days of adrenocorticotropic hormone (ACTH. No predictor could be identified for abnormal psychomotor development. Discussion and Conclusion: In our study, we could demonstrate two factors that predict seizure freedom. The cognitive outcome and seizure control in this group of children are comparable to the existing literature. However, the cognitive outcome revealed by our study and the survey of the literature are discouraging.

  14. Infantile spasms: A prognostic evaluation

    Science.gov (United States)

    Iype, Mary; Saradakutty, Geetha; Kunju, Puthuvathra Abdul Mohammed; Mohan, Devi; Nair, Muttathu Krishnapanicker Chandrasekharan; George, Babu; Ahamed, Shahanaz M.

    2016-01-01

    Background: Few papers address the comprehensive prognosis in infantile spasms and look into the seizure profile and psychomotor outcome. Objective: We aimed to follow up children with infantile spasms to study: a) the etiology, demographics, semiology, electroencephalogram (EEG), and radiological pattern; b) seizure control, psychomotor development, and EEG resolution with treatment; c) the effects of various factors on the control of spasms, resolution of EEG changes, and psychomotor development at 3-year follow-up. Materials and Methods: Fifty newly diagnosed cases with a 1-12 month age of onset and who had hypsarrhythmia in their EEG were recruited and 43 were followed up for 3 years. Results: Of the children followed up, 51% were seizure-free and 37% had a normal EEG at the 3-year follow-up. Autistic features were seen in 74% of the children. Only 22.7% among the seizure-free (11.6% of the total) children had normal vision and hearing, speech with narration, writing skills, gross and fine motor development, and no autism or hyperactivity. On multivariate analysis, two factors could predict bad seizure outcome — the occurrence of other seizures in addition to infantile spasms and no response to 28 days of adrenocorticotropic hormone (ACTH). No predictor could be identified for abnormal psychomotor development. Discussion and Conclusion: In our study, we could demonstrate two factors that predict seizure freedom. The cognitive outcome and seizure control in this group of children are comparable to the existing literature. However, the cognitive outcome revealed by our study and the survey of the literature are discouraging. PMID:27293335

  15. Lobular Capillary Hemangioma of the Nasal Cavity: A Retrospective Study of 15 Cases in Taiwan

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    Tzu-Hang Chi Chi

    2014-03-01

    Full Text Available Background: Lobular capillary hemangioma of the nasal cavity is an uncommon benign vascular tumor of unknown etiology. There have been only very few case reports in Taiwan. Aims: This study aimed to analyze the clinical features, radiological findings, treatment modalities, and outcome of lobular capillary hemangioma treated at a teaching hospital in Taiwan during a period of 10 years. Study Design: Descriptive study. Methods: Retrospective chart reviews were performed on patients who were diagnosed with lobular capillary hemangioma of the nasal cavity at Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, from January 2003 to December 2012. Data retrieved included age, gender, clinical symptoms, computed tomography (CT findings, treatment modalities, and outcome for further analysis. Results: Of the 15 patients identified, there were five males and ten females ranging from 17 to 86 years of age, with a mean age of 43.8±20.2. Epistaxis was the most common presenting symptom. All patients presented a unilateral nasal lobular capillary hemangioma. The most commonly affected site was the anterior nasal septum, followed by the inferior turbinate, vestibule, middle turbinate, and posterior nasal septum. All lesions presented as soft tissue density without bony erosions under CT examination. Endoscopic excisional surgery (n=12 or classical local excision (n=3 was performed for complete removal of the hemangioma. No evidence of recurrence was observed with 6 to 75 months of follow-up. Conclusion: Lobular capillary hemangioma of the nasal cavity was usually found to occur in anterior septum with epistaxis. Complete excision with endoscopic surgery or classical local excision was recommended and recurrence can be prevented.

  16. Hepatic hemangioma with atypical sonographic features : value of two-phase spiral CT

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Worl; Cho, June Sik; Lee, Young Hwan; Kang, Yong Soo; Kim, Hyoung Sub; Chung, Yon Su [Chungnam National Univ. College of Medicine, Taejon (Korea, Republic of)

    1997-08-01

    The purpose of this study was to evaluate enhancement patterns, as seen on two-phase spiral CT, of hepatic hemangiomas in which atypical features had been seen on sonography(US) Two-phase spiral CT scanning was performed in 18 patients in whom 24 atypical hemangiomas had been seen on US. Two-phase images were obtained at 25-45 seconds(arterial dominant phase) and 2-5 minutes(equilibrium phase) after the initiation of a bolus injection of contrast material(150ml, 5ml/sec). Enhancement patterns of hemangiomas during each phase were classified as homogeneous high, peripheral high, or low attenuation, and were retrospectively analyzed. In the arterial dominant phase of spiral CT, low attenuation was seen in nine hemangiomas (38%), globular or spotty peripheral high attenuation in 14(58%), and homogeneous high attenuation in one(4%). In the equilibrium phase, enhancement patterns were peripheral high attenuation(partial fill-in) in 18 lesions (75%), and homogeneous high attenuation(complete fill-in) in three (12.5%), In the other three(12.5%) enhancement showed no significant change;in one of these, density was slightly less than in the arterial phase, and two showed subtle peripheral high attenuation. Fourteen hemangiomas (58%) showed globular or spotty peripheral high attenuation in the arterial dominant phase and peripheral or homogeneous high attenuation with progressive centripetal enhancement in the equilibrium phase. Our results suggest that two-phase spiral CT during the arterial dominant and equilibrium phase is useful in differentiating hepatic hemangiomas with atypical features seen on US from malignant hepatic tumors.

  17. [Clinical features and surgical treatment effect of patients with cardiac cavernous hemangioma].

    Science.gov (United States)

    Yang, Q L; Tang, B; Zhou, X H; Wang, J P; Wang, H Y; Wang, S Y

    2017-09-24

    Objective: To investigate the clinical features and surgical treatment effect of patients with cardiac cavernous hemangioma. Methods: Clinical data of 9 patients (5 male, aged from 4 to 53 years old) with cardiac cavernous hemangioma, who underwent surgical treatment from November 2002 to March 2015 and the diagnosis of cardiac cavernous hemangioma was confirmed by postoperative histological examination, were retrospectively analyzed. Effects of surgical treatment were analyzed. Results: Four patients were asymptomatic (heart murmur presented in 3 patients during physical examination). Three patients presented with palpitation, chest distress, and short of breath. One patient presented with epigastric discomfort and another patient presented with intermittent fever for more than 10 months. ST and T wave changes of electrocardiogram were found in 2 patients, cardiac mass was detected in the right heart chamber in 5 patients by echocardiography, and no cardiac mass was detected the rest 4 patients. Cardiac masses were resected en bloc, then the adjacent tissues were repaired in 7 patients, and mass was partially resected due to the involvement with adjacent heart structure. No cardiac mass was found during operation in 1 case, impaired mitral valve structure was excised and postoperative pathologically confirmed as cardiac valve cavernous angioma on the excised mitral valve structure. No signs of recurrence or enlargement of cardiac cavernous hemangioma were found during the 11(10, 11)years follow up. Conclusions: There is no specific clinical feature for patients with cardiac cavernous hemangioma. It is difficult to detect the cardiac valve cavernous angioma by echocardiography before surgery. Individualized surgical treatment is associated with good clinical outcome in this patient cohort. However, the clinical features and surgical treatment effect of patients with cardiac cavernous hemangioma still need to investigate in large sample trial.

  18. Primary spinal epidural cavernous hemangioma: clinical features and surgical outcome in 14 cases.

    Science.gov (United States)

    Li, Teng-Yu; Xu, Yu-Lun; Yang, Jun; Wang, James; Wang, Gui-Huai

    2015-01-01

    The aim of this study was to investigate the clinical characteristics, imaging features, differential diagnosis, treatment options, and prognosis for primary spinal epidural cavernous hemangiomas. Fourteen patients with pathologically diagnosed non-vertebral origin cavernous hemangiomas who had undergone surgery at Beijing Tiantan Hospital between 2003 and 2012 were identified in the hospital's database. The patients' clinical data, imaging characteristics, surgical treatment, and postoperative follow-up were analyzed retrospectively. There were 9 males and 5 females with an average age of 51.64 years. The primary epidural cavernous hemangiomas were located in the cervical spine (2 cases), cervicothoracic junction (2 cases), thoracic spine (8 cases), thoracolumbar junction (1 case), and lumbar spine (1 case). Hemorrhage was confirmed in 4 cases during surgery. Preoperatively 5 lesions were misdiagnosed as schwannoma, 1 was misdiagnosed as a meningioma, and 1 was misdiagnosed as an arachnoid cyst. Preoperative hemorrhages were identified in 2 cases. Three patients had recurrent cavernous hemangiomas. The initial presenting symptoms were local pain in 5 cases, radiculopathy in 6 cases, and myelopathy in 3 cases. Upon admission, 1 patient had radicular symptoms and 13 had myelopathic symptoms. The average symptom duration was 18 months. All patients underwent surgery; complete resection was achieved in 8 cases, subtotal resection in 4 cases, and partial resection in 2 cases. Postoperative follow-up was completed in 10 cases (average follow-up 34 months); 1 patient died, 5 patients showed clinical improvement, and 4 patients remained neurologically unchanged. Total surgical removal of spine epidural cavernous hemangiomas with a chronic course is the optimum treatment and carries a good prognosis. Secondary surgery for recurrent epidural cavernous hemangioma is technically more challenging. In patients with profound myelopathy from acute hemorrhage, even prompt surgical

  19. Trabajo infantil: una realidad avasallante

    OpenAIRE

    Abud Rodríguez, Silvina Vanesa

    2015-01-01

    p. 87-89 El trabajo infantil es una realidad que se ha venido gestando a lo largo de la historia, en especial desde la revolución industrial. Existe en todos los países del mundo, sin importar sus niveles de desarrollo, sus modelos económicos o las ideologías de sus gobernantes. Es de vital importancia conocer cuáles son los desafíos que asume el Estado como principal proveedor de respuestas a las necesidades de los niños y niñas que se encuentran en situación de vulnerabilidad. La present...

  20. Cuento infantil ilustrado. Fisicamente editado

    OpenAIRE

    SÁNCHEZ FLORES, CRISTINA

    2015-01-01

    Se trata de un proyecto enfocado a la creación de un cuento infantil, escrito e ilustrado por la alumna. La memoria detalla cada parte del trabajo en su totalidad, describiendo de forma concisa el trabajo realizado en estos últimos meses, con el fin de crear un proyecto donde se aplique, integre y desarrolle los conocimientos, capacidades competencias y habilidades adquiridas durante los cuatro años del grado en Bellas Artes. El proyecto se ha basado en la ilustración, una de las muchas ramas...

  1. Significados culturais da asma infantil

    OpenAIRE

    Frota,Mirna Albuquerque; Martins,Mariana Cavalcante; Santos,Rita de Cássia Andrade Neiva

    2008-01-01

    OBJETIVO: Analisar os significados culturais da asma infantil com origem na mãe-cuidadora. PROCEDIMENTOS METODOLÓGICOS: Pesquisa qualitativa realizada em 2004, no município de Fortaleza, CE. Foi utilizada a observação participante com abordagem etnográfica e entrevistas com sete mães acompanhantes de seus filhos em unidade de emergência hospitalar. Os significados das falas das mães foram identificados utilizando-se a técnica de análise temática. ANÁLISE DOS RESULTADOS: Foram identificadas du...

  2. Magnetic resonance imaging of a small vessel hepatic hemangioma in a cirrhotic patient with histopathologic correlation.

    Science.gov (United States)

    Lewis, Sara; Aljarallah, Badr; Trivedi, Anshu; Thung, Swan N

    2015-01-01

    The authors report and discuss a rare case of a small vessel hepatic hemangioma in a 59-year-old patient with liver cirrhosis, which was pre-procedurally characterized as indeterminate due to atypical magnetic resonance imaging (MRI) features. This manuscript reviews the MRI features with pathologic correlation, emphasizes the importance of accurate characterization of liver lesions, and discusses the role of biopsy. We believe this is the first reported case of a small vessel hemangioma in liver cirrhosis with imaging and histopathologic correlation. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Prostate-Specific Membrane Antigen PET/CT Findings for Hepatic Hemangioma.

    Science.gov (United States)

    Bhardwaj, Hemant; Stephens, Maximilian; Bhatt, Manoj; Thomas, Paul Anthony

    2016-12-01

    We report a case of a benign liver hemangioma with intense prostate-specific membrane antigen (PSMA) uptake on Ga PET/CT. A 77-year-old man with prostate adenocarcinoma underwent routine staging with PSMA PET/CT. This revealed an intensely PSMA-avid liver lesion. The known prostate adenocarcinoma was localized and had mild uptake. Diagnostic CT and MRI were characteristic of a hemangioma without interval growth over a 3-month period. PSMA PET/CT is becoming increasingly popular for staging in prostate cancer, and the presence of PSMA uptake in extra-prostatic tumors is being increasingly documented.

  4. Incidental visualization of hepatic hemangioma by Tc-99m-HDP bone scan

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yong An; O, Joo Hyun; Kim, Jung Ho; Yoo, Ie Ryung; Kim, Sung Hoon; Sohn, Hyung Sun; Chung, Soo Kyo [College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of)

    2005-08-15

    Hepatic hemangioma is the most common benign liver tumor and must be considered in the differential diagnosis of other space occupying hepatic masses. A 54-year-old man was referred to evaluate bone metastases of lung adenocarcinoma. In our case, we thought that a focal hepatic uptake in the bone scan was a metastatic lesion because of underlying lung adenocarcinoma. However, the findings of abdominal CT and Tc-99m RBC scan results were deemed to be characteristic of hepatic hemangioma. The biopsy of the lesion was not performed.

  5. Vitrectomy for circumscribed choroidal hemangioma with exudative retinal detachment refractory to transpupillary thermotherapy

    Directory of Open Access Journals (Sweden)

    Shukla Dhananjay

    2007-01-01

    Full Text Available We report successful surgical management of a circumscribed choroidal hemangioma with exudative retinal detachment refractory to transpupillary thermotherapy (TTT. A 33-year-old man with symptomatic serous macular detachment in the left eye (Snellen acuity: 20/200 secondary to a paramacular choroidal hemangioma was treated with TTT. The nonresponsive detachment was subsequently managed by vitrectomy, endophotocoagulation and silicon-oil tamponade. It resulted in complete resolution of the tumor and the detachment. Silicon oil was removed at four months. Visual acuity improved to 20/80 by the last follow-up visit at 10 months without any recurrence.

  6. Hepatic failure in a rapidly involuting congenital hemangioma of the liver: failure of embolotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Zenzen, Wendy; Alomari, Ahmad I. [Children' s Hospital Boston, Division of Vascular and Interventional Radiology, Department of Radiology, Boston, MA (United States); Perez-Atayde, Antonio R. [Children' s Hospital Boston and Harvard Medical School, Department of Pathology, Boston, MA (United States); Elisofon, Scott A. [Children' s Hospital Boston and Harvard Medical School, Division of Gastroenterology, Boston, MA (United States); Bae Kim, Heung [Children' s Hospital Boston and Harvard Medical School, Department of Surgery, Boston, MA (United States)

    2009-10-15

    We report the clinical course, imaging findings, and management of a rare case of rapidly involuting congenital hemangioma of the liver in a newborn girl. The baby presented with severe progressive hepatic dysfunction and cardiomegaly. Multimodality imaging demonstrated a large hypervascular solitary hepatic mass with marked transhepatic shunting, consistent with rapidly involuting congenital hemangioma. Because medical therapy failed, transarterial and transvenous embolization was performed with the main intention to improve the hepatic perfusion and function. Unfortunately, despite improvement in the cardiac overload, liver function continued to deteriorate. The baby eventually underwent successful liver transplantation. (orig.)

  7. Massage for Infantile Colic: Review and Literature

    Directory of Open Access Journals (Sweden)

    Hamidreza Bahrami

    2016-06-01

    Full Text Available Background Infantile colic is a painful phase in the first months of infancy but no safe and effective conventional treatment exists. Massage is used in traditional medicine as a control and treatment method for infantile colic. The aim of this study is to evaluate the efficacy and safety of massage in the control and treatment of infantile colic. Materials and Methods We searched international database such as PubMed, EMBASE, Cochrane library, and Iranian databases such as SID, Magiran, Iranmedex using a searching strategy with key words "Infantile colic", "Massage", "Complementary of Alternative Medicine" during 2000 to 2015. Analysis of data extraction and quality evaluation of the literature were performed independently by two investigators. Results Most articles provides the strongest evidence for benefits of massage in stress, anxiety reduction, pain control, cancer, skin disease, weight gain, sleep, promote growth, development in premature infants, neuromuscular and gastrointestinal disease such as infantile colic. The infantile colic massage helps relax the gastrointestinal tract and good digestion.   Conclusion Our findings demonstrated that pediatric massage therapy is effective in the treatment of infantile colic.  Compared to other possible treatments for colic, massage is a safe and enjoyable procedure; the risk of serious adverse effects is low. The pediatrician should feel comfortable discussing massage therapy with patients and be able to refer patients to a qualified massage therapist as appropriate.

  8. VIOLENCIA FAMILIAR Y MALTRATO INFANTIL

    Directory of Open Access Journals (Sweden)

    María Inés Bringiotti

    2005-01-01

    Full Text Available Este trabajo analiza las implicaciones del concepto "familia" señalando la multiplicidad de fenómenos y situaciones incluidos en el mismo. Su elucidación permitirá determinar los diversos tipos de familia y de riesgo que podemos encontrar en nuestro trabajo cotidiano. La evolución de ese concepto está directamente influida por las determinantes socioestructurales y culturales que en cada momento histórico contextualizan a los sujetos, así como las posibles situaciones de riesgo que deben enfrentar y los recursos con los que cuentan. Se analiza la influencia de las representaciones acerca de cómo debe ser una familia, en la actualidad las familias presentan diferentes formas o estructuras y ello no implica el cumplimiento o no de sus funciones. Esto permitirá establecer adecuadamente las diferentes estrategias de prevención y abordaje aplicables a cada situación. Se ejemplificará concretamente con situaciones problemáticas relacionados a los casos de violencia familiar y maltrato infantil, concretamente con la negligencia y el abuso sexual infantil.

  9. Surdez infantil Childhood hearing impairment

    Directory of Open Access Journals (Sweden)

    Pedro Oliveira

    2002-05-01

    Full Text Available A Surdez Infantil é considerada actualmente um verdadeiro problema de Saúde Pública devido não só à sua elevada prevalência, mas sobretudo às múltiplas conseqüências que acarreta sob os mais variados prismas. Trata-se de um tema em constante evolução, sendo necessárias freqüentes actualizações por forma a acompanhar os avanços da técnica e do conhecimento. Este trabalho visa abordar de uma forma global mas sucinta o problema Surdez Infantil, dando particular ênfase aos Modelos de Rastreio e aos Métodos utilizados com esse fim.Childhood Hearing Impairment is nowadays considered as a Health Care matter due to its high prevalence and to its multiple consequences. As a developing subject, frequent updates are justified to keep up with the evolution of techniques and knowledge. This paper aims to discuss the matter from a global point of view, paying particular attention to the Screening Models and Instruments available.

  10. Infantile Colic: Recognition and Treatment.

    Science.gov (United States)

    Johnson, Jeremy D; Cocker, Katherine; Chang, Elisabeth

    2015-10-01

    Infantile colic is a benign process in which an infant has paroxysms of inconsolable crying for more than three hours per day, more than three days per week, for longer than three weeks. It affects approximately 10% to 40% of infants worldwide and peaks at around six weeks of age, with symptoms resolving by three to six months of age. The incidence is equal between sexes, and there is no correlation with type of feeding (breast vs. bottle), gestational age, or socioeconomic status. The cause of infantile colic is not known; proposed causes include alterations in fecal microflora, intolerance to cow's milk protein or lactose, gastrointestinal immaturity or inflammation, increased serotonin secretion, poor feeding technique, and maternal smoking or nicotine replacement therapy. Colic is a diagnosis of exclusion after a detailed history and physical examination have ruled out concerning causes. Parental support and reassurance are key components of the management of colic. Simethicone and proton pump inhibitors are ineffective for the treatment of colic, and dicyclomine is contraindicated. Treatment options for breastfed infants include the probiotic Lactobacillus reuteri (strain DSM 17938) and reducing maternal dietary allergen intake. Switching to a hydrolyzed formula is an option for formula-fed infants. Evidence does not support chiropractic or osteopathic manipulation, infant massage, swaddling, acupuncture, or herbal supplements.

  11. "Pseudo washout" sign in high-flow hepatic hemangioma on gadoxetic acid contrast-enhanced MRI mimicking hypervascular tumor.

    Science.gov (United States)

    Doo, Kyung Won; Lee, Chang Hee; Choi, Jae Woong; Lee, Jongmee; Kim, Kyeong Ah; Park, Cheol Min

    2009-12-01

    The purpose of this article is to describe the "pseudo washout" sign of high-flow hepatic hemangioma that mimics hypervascular tumor on gadoxetic acid-enhanced MRI. High-flow hemangiomas might show relatively low signal intensity because of gadoxetic acid contrast uptake in the surrounding normal liver parenchyma during the equilibrium (3-minute delay) phase. Such findings are called pseudo washout and can mimic hypervascular hepatic tumors. However, high-flow hemangioma can be diagnosed by observing bright signal intensity on T2-weighted imaging, arterial phase-dominant enhancement, pseudo washout sign during the equilibrium phase, and isointense or slightly increased signal intensity on subtraction images.

  12. In Utero Sonographic Findings of Giant Hepatic Hemangioma and Associated Perinatal Complications: A Report of Two Cases

    OpenAIRE

    Imai, Hiromi; Hidaka, Nobuhiro; Murakami, Takeshi; Kido, Saki; Yumoto, Yasuo; Fukushima, Kotaro; Kato, Kiyoko

    2015-01-01

    It is uncommon to diagnose fetal hepatic hemangioma during the antenatal period. We describe herein two patients with a giant hepatic hemangioma detected antenatally, both with perinatal complications. In Case 1, a fetal intra-abdominal mass, measuring 63 mm × 50 mm × 74 mm, was observed below the right lobe of the liver, and the presumptive antenatal diagnosis of hepatic hemangioma was made at 37 weeks of gestation. Antenatal imaging suggested an intratumoral hemorrhage, but postnatal clinic...

  13. Gamma Knife radiosurgery for hemangioma of the cavernous sinus.

    Science.gov (United States)

    Lee, Cheng-Chia; Sheehan, Jason P; Kano, Hideyuki; Akpinar, Berkcan; Martinez-Alvarez, Roberto; Martinez-Moreno, Nuria; Guo, Wan-Yuo; Lunsford, L Dade; Liu, Kang-Du

    2017-05-01

    OBJECTIVE Cavernous sinus hemangiomas (CSHs) are rare vascular tumors. A direct microsurgical approach usually results in massive hemorrhage and incomplete tumor resection. Although stereotactic radiosurgery (SRS) has emerged as a therapeutic alternative to microsurgery, outcome studies are few. Authors of the present study evaluated the role of SRS for CSH. METHODS An international multicenter study was conducted to review outcome data in 31 patients with CSH. Eleven patients had initial microsurgery before SRS, and the other 20 patients (64.5%) underwent Gamma Knife SRS as the primary management for their CSH. Median age at the time of radiosurgery was 47 years, and 77.4% of patients had cranial nerve dysfunction before SRS. Patients received a median tumor margin dose of 12.6 Gy (range 12-19 Gy) at a median isodose of 55%. RESULTS Tumor regression was confirmed by imaging in all 31 patients, and all patients had greater than 50% reduction in tumor volume at 6 months post-SRS. No patient had delayed tumor growth, new cranial neuropathy, visual function deterioration, adverse radiation effects, or hypopituitarism after SRS. Twenty-four patients had presented with cranial nerve disorders before SRS, and 6 (25%) of them had gradual improvement. Four (66.7%) of the 6 patients with orbital symptoms had symptomatic relief at the last follow-up. CONCLUSIONS Stereotactic radiosurgery was effective in reducing the volume of CSH and attaining long-term tumor control in all patients at a median of 40 months. The authors' experience suggests that SRS is a reasonable primary and adjuvant treatment modality for patients in whom a CSH is diagnosed.

  14. Clinical therapeutic effect of two therapies on circumscribed choroidal hemangioma

    Directory of Open Access Journals (Sweden)

    Le-Le Huang

    2014-03-01

    Full Text Available AIM:To observe the clinical therapeutic effect of photodynamic therapy(PDTand transpupillary thermotherapy(TTTon circumscribed choroid hemangioma(CCH.METHODS: Totally 24 cases(24 eyesof CCH were selected in this study. Twelve of them had undergone TTT, and the other 12 were treated by PDT. The changes of tumors were examined by best corrected visual acuity, results of fundus photography, and direct ophthalmoscopy; the changes of tumors' sizes and heights were examined by B-ultrasound examination and coloured doppler imaging; the presence of serous subretinal fluid were examined by optical coherence tomography(OCT; the leakage of tumors and complications were analyzed by fluorescence fundus angiography(FFAand indocyanine green angiography(ICGA.RESULTS: In all cases, the tumors shrinked back, the blood flows tuned negative, the fluorescence leakages lessened and the serous retinal detachments resolved completely according to OCT, FFA, ICGA and coloured doppler imaging. In the 12 patients treated by TTT, visual acuity improved in 33.3%, unchanged in 33.3%, and droped in 33.3% too; the results of fundus examinations showed obvious pigmentation and atrophy tumor with organized scar. In the 12 patients treated by PDT, visual acuity improved in 66.7%, unchanged in 33.3%, and none droped; the results of fundus examinations showed slight pigment derangement, atrophy tumor tuned white, and normal blood vessel undamaged.CONCLUSION: Both TTT and PDT can make the tumor atrophy and the exudation absorbed. Unlike TTT, PDT damages little normal tissue, and has higher security.

  15. Extradural transcavernous approach to cavernous sinus cavernous hemangiomas.

    Science.gov (United States)

    Li, Mei-Hua; Zhao, Jian-Lan; Li, Yi-Yun; Zeng, Chun-Hui; Xu, Geng-Sheng; Hong, Tao

    2015-09-01

    Cavernous sinus cavernous hemangioma (CSCH) is a rare extra-axial vascular lesion and is difficult to be removed due to their location, propensity for profuse bleeding during surgery, and relationship to complex neurovascular structures. The purpose of this study is to report our experience of the removal of CSCHs through a completely extradural transcavernous approach. Twelve patients with CSCH, who were operated through a purely extradural approach, were retrospectively studied. Clinical symptoms and signs, radiographic characteristics, operative techniques and outcomes of these patients were analyzed. Headache and visual impairment were the most common clinical symptoms, followed by facial hypesthesia and ptosis. Radiographically, CSCHs have a characteristic pattern. On computed tomography (CT) scans, CSCHs are isodense or minimally hyperdense, with an intense homogenous contrast administration. Magnetic resonance image (MRI) scans revealed well-demarcated and hypo- to isointense lesions on T1-weighted images and characteristically, markedly hyperintense lesions on T2-weighted images. The T2-weighted images showed a marked homogeneous and an intense enhancement after contrast administration. All CSCHs were treated by a completely extradural transcavernous approach. Gross total excision was achieved in all 12 patients. Post-operative complication included transient cranial nerve dysfunction for 2-3 months in eight patients, and three patients developed a permanent VI nerve palsy. The follow-up period ranged from 4 to 117 months (mean 62 months), and no patient had experienced tumor recurrence. CSCHs are rare and challenging skull base tumors. The microsurgical resection, using an extradural transcavernous approach which allows complete tumor resection with an acceptable intraoperative and postoperative complications, should be considered as a favorable choice among all treatments. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. A case of liver hemangioma with markedly reduced tumor size after metformin treatment: a case report.

    Science.gov (United States)

    Ono, Minoru; Sawada, Koji; Okumura, Toshikatsu

    2017-02-01

    A 52-year-old man with a 9-year history of hepatic hemangioma was treated with the anti-diabetic drug metformin, resulting in complete remission of the tumor. In 2006, a hemangioma with diameter of 20 × 25 mm was detected incidentally in the liver. The results of imaging studies including ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) were all compatible with that of hepatic hemangioma. The patient consequently underwent imaging annually from 2006 to 2015. The tumor size increased slightly, to 30 × 35 mm in 2012; however, the general tumor characteristics in imaging were not changed. Beginning May 2012, metformin (750 mg/day) was administered because of an increase in blood sugar and hemoglobin A1c levels. After the start of metformin treatment, the tumor size on US gradually decreased. Finally, in October 2015, the tumor was no longer detected. Dynamic CT study also demonstrated markedly reduced tumor size, with a decrease of 2-3 mm in diameter. These results indicate that metformin treatment strongly suppressed cell proliferation in liver hemangioma. The anti-angiogenic effect of metformin was indicated as a possible cause of the reduction in tumor size.

  17. Cavernous hemangiomas of the liver: are there any indications for resection?

    Science.gov (United States)

    Farges, O; Daradkeh, S; Bismuth, H

    1995-01-01

    A total of 163 patients with cavernous hemangiomas of the liver were managed at Paul Brousse Hospital between 1970 and 1992. The tumor was smaller than 4 cm in 54 patients and larger than 10 cm in 38 patients. The diagnostic sensitivities of the imaging procedures were as follows: ultrasonography 61%; angio-computed tomography scanning 77%; angiography 85%; magnetic resonance imaging 92%. The tumor was diagnosed during the evaluation of abdominal pain in 87 patients. Forty-seven patients had associated disorders that proved to be responsible for the symptoms. Fourteen patients with incapacitating symptoms underwent specific treatment of their tumor: resection (n = 8), embolization (n = 5), or hepatic artery ligation (n = 1). Seven of these patients are still symptomatic, indicating that the hemangioma was in fact not responsible for their symptoms. Twenty-five patients were given oral analgesic medications; in 21 the symptoms diminished or became infrequent. Unresected hemangiomas did not significantly increase in size, nor have they become complicated or symptomatic. These results indicate that resection of liver hemangiomas is rarely required, and such treatment should be carefully balanced against the risk inherent in liver surgery.

  18. Role of fractionated radiotherapy in patients with hemangioma of the cavernous sinus

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sun Min; Yoon, Sang Min; Lee, Su Min; Park, Jin Hong; Song, Si Yeol; Lee, Sang Wook; Ahn, Seung Do; Kim, Jong Hoon; Choi, Eun Kyung [Dept. of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2017-09-15

    We performed this retrospective study to investigate the outcomes of patients with hemangioma of the cavernous sinus after fractionated radiotherapy. We analyzed 10 patients with hemangioma of the cavernous sinus who were treated with conventional radiotherapy between January 2000 and December 2016. The median patient age was 54 years (range, 31–65 years), and 8 patients (80.0%) were female. The mean hemangioma volume was 34.1 cm{sup 3} (range, 6.8–83.2 cm{sup 3}), and fractionated radiation was administered to a total dose of 50–54 Gy with a daily dose of 2 Gy. The median follow-up period was 6.8 years (range, 2.2–8.8 years). At last follow-up, the volume of the tumor had decreased in all patients. The average tumor volume reduction rate from the initial volume was 72.9% (range, 18.9–95.3%). All 10 of the cranial neuropathies observed before radiation therapy had improved, with complete symptomatic remission in 9 cases (90%) and partial remission in 1 case (10%). No new acute neurologic impairments were reported after radiotherapy. One probable compressive optic neuropathy was observed at 1 year after radiotherapy. Fractionated radiotherapy achieves both symptomatic and radiologic improvements. It is a well-tolerated treatment modality for hemangiomas of the cavernous sinus.

  19. Clinical effect of radiofrequency ablation in treatment of hepatic hemangioma

    Directory of Open Access Journals (Sweden)

    SUN Libo

    2017-01-01

    Full Text Available ObjectiveTo investigate the clinical effect and application experience of radiofrequency ablation in the treatment of hepatic hemangioma. MethodsA retrospective analysis was performed for the clinical data of 34 patients with hepatic hemangioma who underwent radiofrequency ablation in Beijing You′an Hospital from January 2011 to June 2015. Among these patients, 22 underwent ultrasound-guided percutaneous transhepatic radiofrequency ablation (PRFA, 10 underwent laparoscopic radiofrequency ablation (LRFA, and 2 underwent open hepatectomy combined with hepatic hemangioma radiofrequency ablation (OHRFA. The intraoperative and postoperative conditions were compared between patients undergoing different methods of radiofrequency ablation. ResultsAll the patients underwent successful radiofrequency ablation. The mean time of operation in PRFA group, LRFA group, and OHRFA group was 75.45±27.33 min, 97.90±32.37 min, and 192.5 min, respectively, and the median hospital stay in these groups was 3 d, 3 d, and 10.5 d, respectively. There were no serious complications during and after surgery. The complete remission rate at 1 month after surgery was 94.1%(32/34. The patients were followed up for 6-24 months and no recurrence was observed. ConclusionRadiofrequency ablation is a safe and effective procedure for the treatment of hepatic hemangioma. Strict control of surgical indications and selection of proper radiofrequency ablation approach are of great importance.

  20. Diagnosis and management of giant hepatic hemangioma: the usefulness of contrast-enhanced ultrasonography.

    Science.gov (United States)

    Maruyama, Masaki; Isokawa, Osamu; Hoshiyama, Koki; Hoshiyama, Ayako; Hoshiyama, Mari; Hoshiyama, Yoshihiro

    2013-01-01

    Giant hepatic hemangiomas, though often asymptomatic, may require intervention if rapid growth occurs. The imaging studies including the computed tomography, magnetic resonance imaging, and ultrasonography, and so on are effective for the diagnosis and the management of this tumor; however, due to its size and various patterns of these studies, we need to carefully consider the therapeutic methods. Compared to the cost needed for these modalities, recently developed and approved Perflubutane- (Sonazoid-) based contrast agent enhanced ultrasonography is reasonable and safe. The major advantage is the real-time observation of the vascular structure and function of the Kupffer cells. By this procedure, we can carefully follow the tumor growth or character change in a hemangioma and decide the timing of therapeutic intervention, since abdominal pain, abdominal mass, consumptive coagulopathy, and hemangioma growth are the signs for the therapeutic intervention. We reviewed recent reports about Sonazoid-based enhancement and also showed the representative images collected in our department. This is the first review showing the detailed findings of the giant hemangiomas using Perflubutane (Sonazoid). This review will help the physician in making the decision, and we hope that Sonazoid will gain widespread acceptance in the near future.

  1. Multimodal management of endangering hepatic hemangioma: impact on transplant avoidance: a descriptive case series.

    Science.gov (United States)

    Draper, Haley; Diamond, Ivan R; Temple, Michael; John, Philip; Ng, Vicky; Fecteau, Annie

    2008-01-01

    To examine the results of the multimodal management of patients with endangering hepatic hemangioma associated with systemic compromise. Retrospective descriptive case series of children with endangering hepatic hemangioma managed at our institution between January 1996 and June 2006. Six children (5 females) presented with endangering hepatic hemangioma with systemic effects during the index time period. Mean age at presentation was 1.9 months (range, 2 days to 4 months). All patients received medical treatment, and all patients also underwent hepatic embolization, with a median number of procedures of 2 (range, 1-6). Two patients died, one of sepsis and one of progressive liver failure in a child presenting with advanced liver disease owing to neonatal hemochromatosis that was unrecognized at the time. The remaining 4 patients all recovered and were discharged. With mean postprocedure follow-up of 2.11 years (range, 0-6.2 years), all remain well. Multimodal management of endangering hepatic hemangioma is a strategy that deserves consideration in the management of these patients. Although the strategy requires further evaluation as to its safety and efficacy, the procedure has the potential to decrease the need for liver transplantation because of treatment failures in this population.

  2. Ultrasonographic and T2-weighted MR imaging studies on hepatic hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Niizawa, Makoto; Kuramitsu, Tomoyuki; Naganuma, Toshio; Yoshida, Tsukasa [Akita City Hospital (Japan); Masamune, Osamu

    1995-12-01

    We investigated the correlations between ultrasonography (US) and magnetic resonance (MR) imaging of hepatic hemangiomas to evaluate their heterogeneous echo patterns; we examined 20 hemangiomas (over 20 mm in maximal size) in 18 asymptomatic patients by US and MR imaging, and investigated the correlations between these images. T1-weighted images indicated 8 of 20 lesions as heterogeneous, T2-weighted images indicated 12 heterogeneous lesions, and US indicated 19 heterogeneous lesions. The internal pattern was consistent in US and T2-weighted images in 6 lesions, and inconsistent in 6 lesions. US revealed a heterogeneous pattern in 7 lesions in which T2-weighted images revealed a homogeneous pattern. Both US and T2-weighted images revealed a homogeneous pattern in one lesion. US findings of heterogeneous hepatic hemangioma reflect, to some extent, their histological changes based on MR morphology. In the near future, utilization of US equipment will probably permit the sonographic morphology of the heterogeneous hepatic hemangioma to be clarified. (author)

  3. Atypical hepatic hemangiomas with multiple calcifications mimicking hepatic metastases: case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyung Hwan; Kim, Hyun Cheol; Shin, Hyeong Cheol; Park, Seong Il; Kim, Hong Soo; Bae, Won Kyung; Kim, Il Young [Cheonan Hospital, Cheonan (Korea, Republic of); Oh, Mee Hye; Yang, Seung Ha [College of Medicine, Soonchunhyang Univ., Cheonan (Korea, Republic of)

    2004-07-01

    Although hepatic hemangioma is the most common benign tumor of the liver, it is rarely associated with calcifications. We report on the case of an asymptomatic 58-year-old man in whom multiple hepatic masses containing calcifications were discovered incidentally at ultrasonography. The radiologic features mimicked those of multiple hepatic metastases.

  4. Diagnosis and Management of Giant Hepatic Hemangioma: The Usefulness of Contrast-Enhanced Ultrasonography

    Directory of Open Access Journals (Sweden)

    Masaki Maruyama

    2013-01-01

    Full Text Available Giant hepatic hemangiomas, though often asymptomatic, may require intervention if rapid growth occurs. The imaging studies including the computed tomography, magnetic resonance imaging, and ultrasonography, and so on are effective for the diagnosis and the management of this tumor; however, due to its size and various patterns of these studies, we need to carefully consider the therapeutic methods. Compared to the cost needed for these modalities, recently developed and approved Perflubutane- (Sonazoid- based contrast agent enhanced ultrasonography is reasonable and safe. The major advantage is the real-time observation of the vascular structure and function of the Kupffer cells. By this procedure, we can carefully follow the tumor growth or character change in a hemangioma and decide the timing of therapeutic intervention, since abdominal pain, abdominal mass, consumptive coagulopathy, and hemangioma growth are the signs for the therapeutic intervention. We reviewed recent reports about Sonazoid-based enhancement and also showed the representative images collected in our department. This is the first review showing the detailed findings of the giant hemangiomas using Perflubutane (Sonazoid. This review will help the physician in making the decision, and we hope that Sonazoid will gain widespread acceptance in the near future.

  5. Effect of Lesion Size in the Diagnosis of Hepatic Hemangioma with Tc-99m Erythrocyte Scintigraphy

    Directory of Open Access Journals (Sweden)

    Tansel Ansal Balcı

    2012-04-01

    Full Text Available Aim: Diagnosis of the hepatic hemangiomas is sometimes difficult by means of computed tomography (CT or ultrasound (USG. This kind of lesions can be accurately identified by Tc-99m labeled erythrocyte -red blood cell (RBC imaging. However there are controversial results about small lesions (

  6. Spontaneous rupture of giant hepatic hemangioma: a rare source of hemoperitoneum. Case report.

    Science.gov (United States)

    Santos Rodrigues, A L; Silva Santana, A C; Carvalho Araújo, K; Crociati Meguins, L; Felgueiras Rolo, D; Pereira Ferreira, M

    2010-03-01

    Hemoperitoneum due to spontaneous rupture of a hepatic hemangioma is a rare and serious clinical event with a high mortality rate. 25-year-old woman under hormonal treatment for pregnancy with abdominal pain with distension followed by vomits, palpable epigastric mass and paleness of the skin and mucosas. Computed tomography of the abdomen without oral and venous contrast showed a heterogeneous and capsulated tumor of the liver. Exploratory laparotomy was carried out that revealed a large tumor occupying the gastro-hepatic site with partial rupture of the tumor's capsule with bleeding. Because of the close relationship between the tumor and the retro-hepatic inferior vena cava, the partial resection of the tumor was realized. The patient had a good post-operative evolution. The study of the tumor revealed hepatic hemangioma. Hepatic Hemangiomas may evolve to spontaneous rupture leading to hemorrhagic acute abdomen. Surgery is mandatory and the resection of the Hemangioma will depend on the clinical condition of the patient and on the relationship of the tumor with the vascular structures of the liver. Partial resection is a safe choice that saves lives in urgency situations, as the one described herein.

  7. MR imaging of hepatic hemangiomas of infancy and changes seen with interferon alpha-2a treatment

    Energy Technology Data Exchange (ETDEWEB)

    Chung, T. [Department of Radiology, Children`s Hospital, 300 Longwood Avenue, Boston, MA 02115 (United States); Hoffer, F.A. [Department of Radiology, Children`s Hospital, 300 Longwood Avenue, Boston, MA 02115 (United States); Burrows, P.E. [Department of Radiology, Children`s Hospital, 300 Longwood Avenue, Boston, MA 02115 (United States); Paltiel, H.J. [Department of Radiology, Children`s Hospital, 300 Longwood Avenue, Boston, MA 02115 (United States)

    1996-05-01

    The purpose of this study was to describe the appearance on magnetic resonance (MR) imaging of hepatic hemangioma, and how the appearance changes in infants who have received interferon alpha-2a (IFN) treatment. We retrospectively studied 16 MR examinations in seven infants (mean age 3.2 months; range 5 days to 13 months) who were symptomatic with hepatic hemangiomas. Five of these seven patients had MR examinations both before and after treatment with IFN. In six of the seven patients, the hepatic hemangiomas were multicentric; they were usually discrete, well-defined nodules, best seen on T2-weighted images as high intensity lesions. One patient had a large solitary heterogeneous lesion. They all exhibited fast flow (seen as flow voids on spin-echo images and high signal intensity structures on gradient-recalled echo images) and enlarged hepatic arteries and veins. There was enlargement of the proximal abdominal aorta with distal tapering. Treatment was followed by accelerated regression of the hemangiomas in size and number and variable shrinkage of the enlarged vessels. As the tumor nodules regressed, they were replaced by normal-appearing hepatic parenchyma; neither fat nor fibrosis was detected by MR imaging. (orig.). With 4 figs., 1 tab.

  8. Enhancement pattern of small hepatic hemangioma: findings on multiphase spiral CT and dynamic MRI

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Byung In; Lee, Seung Koo; Kim, Myeong Jin; Chung, Jae Joon; Yoo, Hyung Sik; Lee, Jong Tae [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    1999-02-01

    To compare the enhancement characteristics of small hemangiomas seen on multiphase spiral CT and dynamic MR imaging. Thirteen patients with 20 hepatic hemangiomas less than 25mm in diameter underwent both multiphase spiral CT and dynamic MR imaging. All lesions were assigned to one of three classified into 3 categories according to the enhancement pattern seen on multiphase spiral CT : typical delayed pooling, atypical early enhancement, or continuous low attenuation. The enhancement patterns seen on spiral CT and on dynamic MRI were correlated. On CT scans, ten lesions (50%) showed delayed pooling. Six (30%) showed early arterial enhancement and four (20%) showed continuous low attenuation. On delayed-phase MRI, all lesions showed delayed high signal intensity compared to adjacent liver parenchyma. Four of six lesions with early enhancement on CT showed peripheral globular enhancement on early arterial-phase MRI. On multiphase spiral CT scans, small hemangiomas can show variable atypical enhancement features. In this situation, contrast-enhanced dynamic MRI is helpful for the diagnosis of hemangiomas.

  9. Pulmonary embolism due to compression of the inferior vena cava by a hepatic hemangioma.

    Science.gov (United States)

    Paolillo, V; Sicuro, M; Nejrotti, A; Rizzetto, M; Casaccia, M

    1993-01-01

    We describe a 35-year-old man who had a pulmonary embolism with thrombosis of the inferior vena cava, apparently resulting from compression by a hepatic hemangioma. The diagnosis of pulmonary embolism was confirmed by pulmonary angiography; however, the hemangioma was detected only incidentally, as a hyperechoic mass, during an echocardiogram for intracardiac thrombosis. Abdominal sonography, computed tomography, celiac angiography, technetium 99m-labeled red blood cell scintigraphy, and ultrasound-guided liver biopsy all assisted in the diagnosis of hepatic hemangioma and its compression of the inferior vena cava. Because of the multisegmental and perihilar involvement of the tumor, surgery was not performed. For dissolution of the clots, the patient was given thrombolytic therapy followed by heparin administration. He was then placed on long-term warfarin therapy and is well after 5 years; the size of the hemangioma is unchanged. Cases of pulmonary embolism due to diseases of the upper abdominal organs are rare and probably underestimated. This case stresses the need for a systematic investigation of the abdomen when a pulmonary embolism is present without evidence of deep vein thrombosis. Images PMID:8508068

  10. Giant liver hemangioma with adult Kasabach-Merritt syndrome: Case report and literature review.

    Science.gov (United States)

    Liu, Xiaolei; Yang, Zhiying; Tan, Haidong; Xu, Li; Sun, Yongliang; Si, Shuang; Liu, Liguo; Zhou, Wenying; Huang, Jia

    2017-08-01

    Adult Kasabach-Merritt syndrome associated with giant liver hemangioma is rare; to date, most reports have been single-case reports, and no multi-case reports or literature reviews are available. We conducted a retrospective analysis of 5 cases of adult Kasabach-Merritt syndrome associated with giant liver hemangioma treated at our hospital between 2011 and 2016. All 5 patients had varying severities of leukopenia, anemia, thrombocytopenia, prolonged prothrombin time, and hypofibrinogenemia. All the patients underwent surgery: 2 patients had left hemihepatectomy; 1 had enucleation; 1 had a right hemihepatectomy; and 1 had a left trisectionectomy. The 5 patients had an average operative time of 6.9 hours and an average blood loss of 3200 mL. One patient developed a biliary fistula (grade II) after the operation. There was no mortality among 5 patients. The white blood cell counts, hemoglobin, platelets, and prothrombin times of all 5 patients returned to normal after the operation. To date, a total of 11 cases of adult Kasabach-Merritt syndrome associated with giant liver hemangioma have been reported, of which 8 patients underwent surgery, and their platelets and coagulation returned to normal after the operation. Adult Kasabach-Merritt syndrome associated with giant liver hemangioma is uncommon, and surgical treatment is risky. However, resection of the tumor corrected the abnormalities in hematological and coagulative systems.

  11. Tratamiento exitoso de un hemangioma de parótida con propranolol

    National Research Council Canada - National Science Library

    Edelisa Moredo Romo; Fernanda Pastrana Fundora

    2012-01-01

    .... Se presenta el caso clínico de un paciente con diagnóstico de hemangioma de parótida con componente superficial y profundo, tratado con propranolol, con excelente respuesta al tratamiento, involución completa clínica...

  12. Thyroid carcinoma, cataract and hearing loss in a patient after irradiation for facial hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Talmi, Y.; Kalmanovitch, M.; Zohar, Y.

    1988-01-01

    A rare case of a patient irradiated on the right side of the face for a large hemangioma during early childhood is reported. This patient suffers from sensorineural hearing loss in the right ear and a cataract of the right eye, and she underwent surgery for Hurtle cell carcinoma of the thyroid gland. The literature discussing radiation-induced hearing loss is reviewed.

  13. Efficacy and rebound rates in propranolol-treated subglottic hemangioma: A literature review.

    Science.gov (United States)

    Schwartz, Tyler; Faria, John; Pawar, Sachin; Siegel, Dawn; Chun, Robert H

    2017-11-01

    Propranolol has recently become the treatment of choice for management of subglottic and airway hemangiomas. This literature review aimed to determine the success rate of propranolol for managing these lesions as well as the rate of rebound growth following propranolol treatment cessation. Literature search involving MEDLINE and Scopus to identify English-language articles. Studies were identified using hemangioma, subglottic or airway, and propranolol for search terms. Studies were eligible for inclusion if they reported the treatment used, individual deidentified patient data, and contained patients without medical or surgical treatment prior to propranolol therapy RESULTS: Initial review included 107 abstracts. Twenty-four articles including case reports and case series met inclusion criteria and were included in the qualitative analysis. Forty-nine patients were included. Twenty-eight (57%) were treated with propranolol alone, and 20 (41%) were treated with a combination of propranolol and a corticosteroid. Thirty-seven (76%) of patients were treated with a dose of 2 mg/kg/d of propranolol. The initial treatment was successful in 43 (88%) of patients. Rebound growth occurred in four (9%) patients. Overall, six (12%) patients underwent surgical resection. Propranolol is efficacious for treating subglottic hemangiomas. Rebound growth does occur in a small subset of patients during the propranolol wean. Close observation for children during weaning of propranolol therapy for subglottic hemangioma is essential. Adjunctive management strategies need to be used in patients with rebound growth. Laryngoscope, 127:2665-2672, 2017. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  14. Evaluation of hepatic hemangioma by Tc-99 m red blood cell hepatic blood pool scan

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Myung Hee [Chonbuk National University Medical School, Chonju (Korea, Republic of)

    2005-02-15

    Hemangioma is the most common benign tumor of the liver, with a prevalence estimated as high as 7%. Tc-99m red blood cell (RBC) hepatic blood pool scan with single photon emission computed tomography (SPECT) imaging is extremely useful for the confirmation or exclusion of hepatic hemangiomas. The classic finding of absent or decreased perfusion and increased blood pooling ('perfusion/blood pool mismatch') is the key diagnostic element in the diagnosis of hemangiomas. The combination of early arterial flow and delayed blood pooling ('perfusion/blood pool match') is shown uncommonly. In giant hemangioma, filling with radioactivity appears first in the periphery, with progressive central fill-in on sequential RBC blood pool scan. However, the reverse filling pattern, which begins first in the center with progressive peripheral filling, is also rarely seen. Studies with false-positive blood pooling have been reported infrequently in nonhemangiomas, including hemangiosarcoma, hepatocellular carcinoma, hepatic adenoma, and metastatic carcinomas (adenocarcinma of the colon, small cell carcinoma of the lung, neruroendocrine carcinoma). False-negative results have been also reported rarely except for small hemagniomas that are below the limits of spatial resolution of gamma camera.

  15. Role of fractionated radiotherapy in patients with hemangioma of the cavernous sinus

    Science.gov (United States)

    Park, Sunmin; Yoon, Sang Min; Lee, Sumin; Park, Jin-hong; Song, Si Yeol; Lee, Sang-wook; Ahn, Seung Do; Kim, Jong Hoon; Choi, Eun Kyung

    2017-01-01

    Purpose We performed this retrospective study to investigate the outcomes of patients with hemangioma of the cavernous sinus after fractionated radiotherapy. Materials and Methods We analyzed 10 patients with hemangioma of the cavernous sinus who were treated with conventional radiotherapy between January 2000 and December 2016. The median patient age was 54 years (range, 31–65 years), and 8 patients (80.0%) were female. The mean hemangioma volume was 34.1 cm3 (range, 6.8–83.2 cm3), and fractionated radiation was administered to a total dose of 50–54 Gy with a daily dose of 2 Gy. Results The median follow-up period was 6.8 years (range, 2.2–8.8 years). At last follow-up, the volume of the tumor had decreased in all patients. The average tumor volume reduction rate from the initial volume was 72.9% (range, 18.9–95.3%). All 10 of the cranial neuropathies observed before radiation therapy had improved, with complete symptomatic remission in 9 cases (90%) and partial remission in 1 case (10%). No new acute neurologic impairments were reported after radiotherapy. One probable compressive optic neuropathy was observed at 1 year after radiotherapy. Conclusion Fractionated radiotherapy achieves both symptomatic and radiologic improvements. It is a well-tolerated treatment modality for hemangiomas of the cavernous sinus. PMID:29037018

  16. The Art of Mimicry: Anterior Clinoid Dural-Based Cavernous Hemangioma Mistaken for a Meningioma.

    Science.gov (United States)

    Mansour, Tarek R; Medhkour, Yacine; Entezami, Pouya; Mrak, Robert; Schroeder, Jason; Medhkour, Azedine

    2017-04-01

    Cavernous hemangiomas account for 5%-13% of central nervous system vascular lesions. They are usually found intra-axially but rarely involve extra-axial structures, most commonly the middle cranial fossa. A cavernous hemangioma manifesting as a clinoid meningioma is extremely rare. A 36-year-old man presented with an asymptomatic intracranial mass found incidentally after a motor vehicle accident. Preoperative magnetic resonance imaging revealed a well-defined dural-based lesion arising from the right anterior clinoid process that was nearly homogeneously enhancing. The radiologic diagnosis was meningioma. The mass was resected via a right pterional craniotomy with microsurgical technique. Complete resection of the mass was performed with no complications and no significant bleeding. Contrasting with the radiologic and gross tumor appearance, histopathologic examination revealed dilated vascular spaces, sclerotic vessels without intervening neural tissue, and intravascular thrombi suggesting slow blood flow-all consistent with cavernous hemangioma. Anterior clinoid dural-based cavernous hemangiomas are extremely rare. Although preoperative diagnosis is difficult using imaging, this etiology should be considered for any dural-based middle fossa lesion, owing to the tendency for these lesions to bleed heavily during resection in some instances. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Urea immunoliposome inhibits human vascular endothelial cell proliferation for hemangioma treatment

    Science.gov (United States)

    2013-01-01

    Background Urea injection has been used in hemangioma treatment as sclerotherapy. It shrinks vascular endothelial cells and induces degeneration, necrosis, and fibrosis. However, this treatment still has disadvantages, such as lacking targeting and difficulty in controlling the urea dosage. Thus, we designed a urea immunoliposome to improve the efficiency of treatment. Methods The urea liposome was prepared by reverse phase evaporation. Furthermore, the urea immunoliposome was generated by coupling the urea liposome with a vascular endothelial growth factor receptor (VEGFR) monoclonal antibody using the glutaraldehyde cross-linking method. The influence of the urea immunoliposome on cultured human hemangioma vascular endothelial cells was observed preliminarily. Results Urea immunoliposomes showed typical liposome morphology under a transmission electron microscope, with an encapsulation percentage of 54.4% and a coupling rate of 36.84% for anti-VEGFR. Treatment with the urea immunoliposome significantly inhibited the proliferation of hemangioma vascular endothelial cells (HVECs) in a time- and dose-dependent manner. Conclusions The urea immunoliposome that we developed distinctly and persistently inhibited the proliferation of HVECs and is expected to be used in clinical hemangioma treatment. PMID:24266957

  18. Tumefactive presentation of a supratentorial cavernous hemangioma: A report of two cases.

    Science.gov (United States)

    Mohindra, Sandeep; Sodhi, Harsimratbir Singh; Rane, Swapnil

    2013-09-01

    This study reports two children, including a 2-month-old infant, harboring giant cavernous hemangiomas (GCH) in the supratentorial compartment, causing raised intracranial pressure and focal deficits. Relevant demographic details, clinical presentation, and radiological findings of GCH are discussed in light of tumefactive presentation. Differential diagnoses of such radiological findings are elaborated.

  19. Genetics Home Reference: infantile systemic hyalinosis

    Science.gov (United States)

    ... may grow slowly and have bone abnormalities. Although children with infantile systemic hyalinosis have severe physical limitations, mental development is typically normal. Affected individuals often do not survive beyond early childhood due to chronic diarrhea and recurrent infections. Related ...

  20. Linear Nevus Sebaceum Syndrome and Infantile Spasms

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2008-03-01

    Full Text Available Two infants with linear nevus sebaceum syndrome and infantile spasms are reported from Safra Childrens Hospital, Sheba Medical Center, Tel Hashomer, Israel; and Hospital for Sick Children, Toronto, Canada.

  1. Hepatic hemangioma: Correlation of enhancement types with diffusion-weighted MR findings and apparent diffusion coefficients

    Energy Technology Data Exchange (ETDEWEB)

    Goshima, Satoshi [Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194 (Japan)], E-mail: gossy@par.odn.ne.jp; Kanematsu, Masayuki [Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194 (Japan); Department of Radiology Services, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194 (Japan); Kondo, Hiroshi [Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194 (Japan); Yokoyama, Ryujiro; Kajita, Kimihiro [Department of Radiology Services, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194 (Japan); Tsuge, Yusuke [Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194 (Japan); Shiratori, Yoshimune [Department of Medical Informatics, Gifu University School of Medicine, Gifu (Japan); Onozuka, Minoru [Department of Physiology and Neuroscience, Kanagawa Dental College, Yokosuka (Japan); Moriyama, Noriyuki [Research Center for Cancer Prevention and Screening, National Cancer Center Hospital, Tsukiji (Japan)

    2009-05-15

    Purpose: To correlate hepatic hemangioma enhancement types in gadolinium-enhanced magnetic resonance (MR) images with diffusion-weighted MR findings and apparent diffusion coefficients (ADCs). Materials and methods: Respiratory-triggered diffusion-weighted MR images (TR/TE, 2422/46 ms; parallel imaging factor, 2; b factor, 500 s/mm{sup 2}; number of averaging, 6) obtained in 35 patients with 44 hepatic hemangiomas diagnosed by gadolinium-enhanced MR and by follow-up imaging were retrospectively evaluated. Hemangiomas were classified into three enhancement types based on gadolinium-enhanced MR imaging findings: type I, early-enhancement type; type II, peripheral nodular enhancement type; type III, delayed enhancement type. Two blinded readers qualitatively assessed lesion sizes and signal intensities on T2-weighted turbo spin-echo and diffusion-weighted images. The ADCs of hemangiomas were also measured. Results: No significant difference was observed between the three enhancement types in terms of signal intensities on T2-weighted images. Signal intensities on diffusion-weighted images were lower in the order type I to III (P < .01), and mean ADCs were 2.18 x 10{sup -3}, 1.86 x 10{sup -3}, and 1.71 x 10{sup -3} mm{sup 2}/s for types I, II, and III, respectively (P < .01). No correlation was found between lesion sizes and ADCs. Conclusion: Hepatic hemangiomas were found to have enhancement type dependent signal intensities and ADCs on diffusion-weighted MR images. Further studies will have to substantiate that these diffusion patterns might reflect intratumoral blood flow or perfusion.

  2. Efficacy, safety and feasibility of ultrasound-guided percutaneous microwave ablation for large hepatic hemangioma.

    Science.gov (United States)

    Tang, Xiao Yin; Wang, Zhi; Wang, Tao; Cui, Dan; Zhai, Bo

    2015-09-01

    To evaluate the efficacy, safety and feasibility of microwave ablation (MWA) for large (5-10 cm in diameter) hepatic hemangioma. In all, 46 patients with 47 large hepatic hemangiomas were treated with ultrasound-guided percutaneous MWA. The effect of MWA for all patients was evaluated by enhanced magnetic resonance imaging or computed tomography within two months after ablation. A total of 27 male and 19 female patients were enrolled, with an average age of 46 ± 11 years. The average size of hemangiomas was 6.3 ± 1.4 cm (range 5.0-9.6 cm). The initial complete ablation rate was 91.5% (43/47) and the volume of ablated lesions was significantly reduced. The rate of complete necrosis was not associated with the tumor size or location (P = 0.899 and 0.758, respectively). The total complete ablation rate was 95.7% (45/47). Major complications included acute renal dysfunction, hyperbilirubinemia and pleural effusion. No procedure-related death occurred. The average hospitalization stay was 5.7 ± 2.5 days (range 3-17 days). During a follow-up period of 18.2 months (range 4-40 months), one patient developed local tumor progression at the radiofrequency ablation site. Three patients had new hemangiomas in other sites of the liver. At the end of the study all patients were alive and no severe complications occurred. Image-guided MWA is an effective and safe treatment for large hepatic hemangiomas, and can potentially be regarded as the first-line therapy. © 2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

  3. Hepatic hemangioma: correlation of enhancement types with diffusion-weighted MR findings and apparent diffusion coefficients.

    Science.gov (United States)

    Goshima, Satoshi; Kanematsu, Masayuki; Kondo, Hiroshi; Yokoyama, Ryujiro; Kajita, Kimihiro; Tsuge, Yusuke; Shiratori, Yoshimune; Onozuka, Minoru; Moriyama, Noriyuki

    2009-05-01

    To correlate hepatic hemangioma enhancement types in gadolinium-enhanced magnetic resonance (MR) images with diffusion-weighted MR findings and apparent diffusion coefficients (ADCs). Respiratory-triggered diffusion-weighted MR images (TR/TE, 2422/46 ms; parallel imaging factor, 2; b factor, 500 s/mm(2); number of averaging, 6) obtained in 35 patients with 44 hepatic hemangiomas diagnosed by gadolinium-enhanced MR and by follow-up imaging were retrospectively evaluated. Hemangiomas were classified into three enhancement types based on gadolinium-enhanced MR imaging findings: type I, early-enhancement type; type II, peripheral nodular enhancement type; type III, delayed enhancement type. Two blinded readers qualitatively assessed lesion sizes and signal intensities on T2-weighted turbo spin-echo and diffusion-weighted images. The ADCs of hemangiomas were also measured. No significant difference was observed between the three enhancement types in terms of signal intensities on T2-weighted images. Signal intensities on diffusion-weighted images were lower in the order type I to III (P<.01), and mean ADCs were 2.18 x 10(-3), 1.86 x 10(-3), and 1.71 x 10(-3) mm(2)/s for types I, II, and III, respectively (P<.01). No correlation was found between lesion sizes and ADCs. Hepatic hemangiomas were found to have enhancement type dependent signal intensities and ADCs on diffusion-weighted MR images. Further studies will have to substantiate that these diffusion patterns might reflect intratumoral blood flow or perfusion.

  4. Giant cavernous hemangioma coexistent with diffuse hepatic hemangiomatosis presenting as portal vein thrombosis and hepatic lobar atrophy

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Bo Reum; Han, Hyun Young; Choi, So Young; Kim, Joo Heun [Eulji University Hospital, Daejeon(Korea, Republic of)

    2014-03-15

    A combination of giant hepatic hemangioma and diffuse hemangiomatosis is extremely rare in adults. Even when they are large, hemangiomas are soft and rarely compress adjacent structures. A 78-year-old man presented with abdominal pain and distension. Ultrasonography, computed tomography, and magnetic resonance imaging demonstrated a large expansile mass replacing the medial segment and caudate lobe with diffusely scattered nodules in the entire liver. The large hilar mass contained a central nonenhancing area and had a mass effect, leading to left portal vein occlusion. The image findings also revealed two unprecedented findings: left lateral segmental atrophy of the liver and recent portomesenteric vein thrombosis. The hepatic lesions were confirmed with hemangiomas by ultrasonography-guided biopsy. We diagnosed intrahepatic portal vein obstruction caused by a mass effect of giant hepatic hemangioma coexistent with diffuse hemangiomatosis, resulting in hepatic segmental atrophy and extrahepatic portal vein thrombosis.

  5. Giant cavernous hemangioma coexistent with diffuse hepatic hemangiomatosis presenting as portal vein thrombosis and hepatic lobar atrophy

    Directory of Open Access Journals (Sweden)

    Bo Reum Yoo

    2014-01-01

    Full Text Available

    A combination of giant hepatic hemangioma and diffuse hemangiomatosis is extremely rare in adults. Even when they are large, hemangiomas are soft and rarely compress adjacent structures. A 78-year-old man presented with abdominal pain and distension. Ultrasonography, computed tomography, and magnetic resonance imaging demonstrated a large expansile mass replacing the medial segment and caudate lobe with diffusely scattered nodules in the entire liver. The large hilar mass contained a central nonenhancing area and had a mass effect, leading to left portal vein occlusion. The image findings also revealed two unprecedented findings: left lateral segmental atrophy of the liver and recent portomesenteric vein thrombosis. The hepatic lesions were confirmed with hemangiomas by ultrasonography-guided biopsy. We diagnosed intrahepatic portal vein obstruction caused by a mass effect of giant hepatic hemangioma coexistent with diffuse hemangiomatosis, resulting in hepatic segmental atrophy and extrahepatic portal vein thrombosis.

  6. Giant cavernous hemangioma coexistent with diffuse hepatic hemangiomatosis presenting as portal vein thrombosis and hepatic lobar atrophy

    Science.gov (United States)

    2014-01-01

    A combination of giant hepatic hemangioma and diffuse hemangiomatosis is extremely rare in adults. Even when they are large, hemangiomas are soft and rarely compress adjacent structures. A 78-year-old man presented with abdominal pain and distension. Ultrasonography, computed tomography, and magnetic resonance imaging demonstrated a large expansile mass replacing the medial segment and caudate lobe with diffusely scattered nodules in the entire liver. The large hilar mass contained a central nonenhancing area and had a mass effect, leading to left portal vein occlusion. The image findings also revealed two unprecedented findings: left lateral segmental atrophy of the liver and recent portomesenteric vein thrombosis. The hepatic lesions were confirmed with hemangiomas by ultrasonography-guided biopsy. We diagnosed intrahepatic portal vein obstruction caused by a mass effect of giant hepatic hemangioma coexistent with diffuse hemangiomatosis, resulting in hepatic segmental atrophy and extrahepatic portal vein thrombosis. PMID:24936497

  7. Use of Two-dimensional Multiple-slice Magnetic Resonance Hydrography for Diagnosis of Hepatic Hemangiomas and Cysts

    Directory of Open Access Journals (Sweden)

    Ran-Chou Chen

    2011-01-01

    Conclusion: Hepatic hemangiomas and cysts have significantly different signal intensities on non-contrast two-dimensional multiple-slice MRH. This approach uses a non-invasive, reliable, and accurate imaging technique to differentiate the two diagnoses.

  8. Case report: living donor liver transplantation for giant hepatic hemangioma using a right lobe graft without the middle hepatic vein.

    Science.gov (United States)

    Zhong, Lin; Men, Tong-Yi; Yang, Gao-di; Gu, Yan; Chen, Guoqing; Xing, Tong-Hai; Fan, Jun-Wei; Peng, Zhi-Hai

    2014-04-04

    Hepatic hemangioma patients with Kasabach-Merritt syndrome have reportedly been cured by liver transplantation. However, liver transplantation as a potential cure for a stable patient without Kasabach-Merritt syndrome remains debatable. We report the case of a 27-year-old female patient with a giant hepatic hemangioma. The hemangioma measured 50×40×25 cm in size and weighed 15 kg, which is the largest and heaviest hemangioma reported in the literature. The patient showed jaundice, ascites, anemia, and appetite loss; but no disseminated intravascular coagulation was observed through laboratory findings. We successfully operated using a right lobe graft without the middle hepatic vein from a 55-year-old donor. At the long-term follow-up, the patient experienced two acute rejections, which were confirmed by biopsy. However, the patient still survives with good graft function after 50 months.

  9. Multiple hepatic sclerosing hemangioma mimicking metastatic liver tumor successfully treated by laparoscopic surgery: Report of a case

    Directory of Open Access Journals (Sweden)

    Masaki Wakasugi

    2015-01-01

    Conclusion: Sclerosing hemangioma should be included among the differential diagnoses of multiple liver tumors in patients with colorectal cancer. Laparoscopic hepatectomy is useful for diagnostic therapy for undiagnosed multiple liver tumors.

  10. PHACE association with intracranial, oropharyngeal hemangiomas, and an atypical patent ductus arteriosus arising from the tortuous left subclavian artery in a premature infant

    Directory of Open Access Journals (Sweden)

    Do-Hyun Kim

    2012-01-01

    Full Text Available PHACE association is a rare neurocutaneous condition in which facial hemangiomas associate with a spectrum of posterior fossa malformations, arterial cerebrovascular anomalies, cardiovascular anomalies, and eye anomalies. We reported a case of PHACE association in a premature infant showing facial, intracranial, and oropharyngeal hemangiomas with evidence of the Dandy-Walker variant and complicated cardiovascular anomalies, including a right-sided aortic arch and an atypical patent ductus arteriosus arising from a tortuous left subclavian artery. To our knowledge, intracranial hemangiomas are rare in PHACE association, and a concomitant oropharyngeal hemangioma has not been previously reported in the PHACE association literature. In infants presenting with large, plaque-like facial hemangiomas, it is important to conduct active cardiovascular and neurological evaluations. Special attention should be given to the laryngoscopic examination to search for additional hemangiomas in the airway.

  11. Abordagem terapêutica dos hemangiomas cutâneos na infância Therapeutic management of skin hemangiomas in children

    Directory of Open Access Journals (Sweden)

    Adriana Maria da Silva Serra

    2010-06-01

    Full Text Available FUNDAMENTOS: Hemangioma é um tumor benigno de células endoteliais comum na infância e de involução espontânea. OBJETIVO: Avaliar os tratamentos utilizados em 122 pacientes com hemangiomas cutâneos, tratados no Hospital Universitário de Brasília, de março de 2000 a dezembro de 2006. MÉTODOS: Utilizou-se coleta de dados em prontuários e aplicação de questionários aos pais. Foram analisados gênero, fatores pré-natais e perinatais, características clínicas, tipo de tratamento e resultados. RESULTADOS: A razão de sexo (F: M foi de 1,5:1. 42, em pacientes que apresentavam hemangiomas superficiais, 13 profundos e 67 mistos; em 7 pacientes, havia associação com síndromes. Em 79 pacientes, localizavam-se no polo cefálico. Já em 98/122 dos pacientes, foram submetidos a tratamento único e 24/122 a múltiplos. No primeiro grupo, foi utilizada conduta expectante em 38 pacientes, compressão em 3, corticoide sistêmico em 18, corticoide intralesional em 13, corticoide tópico em 4, cirurgia convencional em 12, criocirurgia em 7, luz pulsada em 1 e imiquimod em 2. No segundo grupo, 15 fizeram 2 tipos de tratamentos e 9 necessitaram de 3 ou mais tratamentos. CONCLUSÃO: Os dados obtidos concordam com a literatura mundial, quanto a sexo e localização da lesão. A incidência de hemangiomas presentes ao nascimento foi maior que em outras publicações. Os resultados terapêuticos obtidos foram comparáveis aos publicados na literatura. A identificação dos hemangiomas que necessitam de tratamento, em que momento adequado para intervenção e a melhor opção terapêutica devem ser considerados.BACKGROUND: Hemangiomas are benign, self-involuting tumors of endothelial cells that are common in childhood. OBJECTIVES: To evaluate the treatment of 122 patients with skin hemangiomas treated at a teaching hospital in Brasilia, Brazil between March 2000 and December 2006. MATERIAL AND METHODS: Data were collected from the patients' medical

  12. The impact of share wave elastography in differentiation of hepatic hemangioma from malignant liver tumors in pediatric population.

    Science.gov (United States)

    Özmen, Evrim; Adaletli, Ibrahim; Kayadibi, Yasemin; Emre, Şenol; Kiliç, Fahrettin; Dervişoğlu, Sergülen; Kuruğoğlu, Sebuh; Şenyüz, Osman Faruk

    2014-09-01

    In children it is crucial to differentiate malignant liver tumors from the most common benign tumor, hepatic hemangiomas since the treatment strategies are quite different. We aimed to evaluate the efficiency of shear wave elastography (SWE) technique in differentiation of malignant hepatic tumors and hepatic hemangiomas. Twenty patients with hepatic tumor were included in our study. Two radiologists performed SWE for 13 patients with malignant hepatic tumors including hepatoblastoma (n=7), hepatocellular carcinoma (n=3), metastasis (n=2), embryonal sarcoma (n=1) and 7 patients with hepatic hemangioma. All of our patients were between the age of 1 and 192 months (mean age: 56.88 months). Receiver operating characteristic analysis was achieved to evaluate the diagnostic accuracy of SWE and to determine the optimal cut-off value in differentiation hepatic hemangioma from malignant hepatic tumors. The mean SWE values (in kPa) for the first observer were 46.94 (13.8-145) and 22.38 (6.6-49.6) and those for the second observer were 57.91 (11-237) and 23.87 (6.4-57.5), respectively for malignant hepatic tumors and hepatic hemangiomas. The SWE values of malignant hepatic tumors were significantly higher than those of hepatic hemangioma (p=0.02). The inter-observer agreement was almost perfect (0.81). The area under the receiver operating characteristic curve of SWE for differentiating the hepatic hemangioma from malignant hepatic tumors was 0.77 with a sensitivity of 72.7% and a specificity of 66.7% at a cutoff value of 23.62 with 95% confidence interval. Shear wave elastography can be helpful in differentiation of malignant hepatic tumors and hepatic hemangioma. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  13. Intratumoral coagulation by radiofrequency ablation facilitated the laparoscopic resection of giant hepatic hemangioma: a surgical technique report of two cases.

    Science.gov (United States)

    Wang, Shaohong; Gao, Jun; Yang, Mengmeng; Ke, Shan; Ding, Xuemei; Kong, Jian; Xu, Li; Sun, Wenbing

    2017-08-01

    Traditionally, open hepatic resection is the first choice of treatment for symptomatic enlarging hepatic hemangiomas, which requires a large abdominal incision and is associated with substantial recovery time and morbidity. Minimally invasive laparoscopic resection has been used recently in liver surgery for treating selected hepatic hemangiomas. However, laparoscopic liver surgery poses the significant technical challenges and high rate of conversion. Radiofrequency (RF) ablation has been proved feasible in the treatment of hepatic hemangiomas with a size range of 5.0-9.9 cm. It is controversial to treat giant hepatic hemangiomas (≥10.0 cm) by means of RF ablation, due to the low technique success rate and high incidence of ablation-related complications. We aimed to assess the safety and efficacy of combined laparoscopic resection with intratumoral RF-induced coagulation for giant hepatic hemangiomas. We treated 2 patients with giant subcapsular hepatic hemangioma (12.0 cm and 13.1 cm in diameters respectively) by laparoscopic resection following intratumoral coagulation of the tumor with RF ablation. Blood loss during resection was 100 ml (case 1) and 300ml (case 2) respectively. No blood transfusion and dialysis were needed during perioperative period. The two patients were discharged 6 days (case 1) and 12 days (case 2) after surgery without any complications, respectively. Postoperative contrast-enhanced CT follow up showed there was no residual tumor. It is feasible to treat giant subcapsular hepatic hemangioma by laparoscopic tumor resection boosted by intratumoral coagulation using RF ablation, which may open a new avenue for treating giant hemangioma.

  14. A Case of Hepatic Hemangioma Detected by Blood Pool with {sup 99m}Tc Human Serum Albumin

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Hwi Joong; Moon, Hee Bum; Kwon, In Soon; Choi, Kang Won; Kim, Chung Yong; Koh, Chang Soon [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1979-03-15

    A case of hepatic hemangioma is presented in which blood pool imaging by {sup 99m}Tc-HSA provided a definite diagnostic clue. Cavernous hemangiomas are the most common benign tumor of the liver. But the majority of them are asymptomatic and are found incidentally at laparotomy or autopsy. Selective hepatic arteriography has been the most helpful technique for the preoperative diagnosis. Recently radioisotope scan and ultrasonogram proved to be a new, definite and non- invasive diagnostic procedure.

  15. Manipulative therapies for infantile colic.

    Science.gov (United States)

    Dobson, Dawn; Lucassen, Peter L B J; Miller, Joyce J; Vlieger, Arine M; Prescott, Philip; Lewith, George

    2012-12-12

    Infantile colic is a common disorder, affecting around one in six families, and in 2001 was reported to cost the UK National Health Service in excess of £65 million per year (Morris 2001). Although it usually remits by six months of age, there is some evidence of longer-term sequelae for both children and parents.Manipulative therapies, such as chiropractic and osteopathy, have been suggested as interventions to reduce the severity of symptoms. To evaluate the results of studies designed to address efficacy or effectiveness of manipulative therapies (specifically, chiropractic, osteopathy and cranial manipulation) for infantile colic in infants less than six months of age. We searched following databases: CENTRAL (2012, Issue 4), MEDLINE (1948 to April Week 3 2012), EMBASE (1980 to 2012 Week 17), CINAHL (1938 to April 2012), PsycINFO (1806 to April 2012), Science Citation Index (1970 to April 2012), Social Science Citation Index (1970 to April 2012), Conference Proceedings Citation Index - Science (1990 to April 2012) and Conference Proceedings Citation Index - Social Science & Humanities (1970 to April 2012). We also searched all available years of LILACS, PEDro, ZETOC, WorldCat, TROVE, DART-Europe, ClinicalTrials.gov and ICTRP (May 2012), and contacted over 90 chiropractic and osteopathic institutions around the world. In addition, we searched CentreWatch, NRR Archive and UKCRN in December 2010. Randomised trials evaluating the effect of chiropractic, osteopathy or cranial osteopathy alone or in conjunction with other interventions for the treatment of infantile colic. In pairs, five of the review authors (a) assessed the eligibility of studies against the inclusion criteria, (b) extracted data from the included studies and (c) assessed the risk of bias for all included studies. Each article or study was assessed independently by two review authors. One review author entered the data into Review Manager software and the team's statistician (PP) reviewed the

  16. Giant Cavernous Hepatic Hemangioma Diagnosed Incidentally in a Perimenopausal Obese Female with Endometrial Adenocarcinoma: A Case Report.

    Science.gov (United States)

    Bara, Tivadar; Gurzu, Simona; Jung, Ioan; Muresan, Mircea; Szederjesi, Janos; Bara, Tivadar

    2016-02-01

    Hemangiomas are the most common benign tumors of the liver, considered giant when they exceed 50-100 mm in diameter. In the present report, we present a case of a 5.2-kg hemangioma of the right hepatic lobe, with hemangiomatous foci in the left lobe, which was incidentally diagnosed in a 53-year-old obese female hospitalized for uterine bleeding. The computed tomographic scan and physical examination revealed a giant abdominal tumor and hepatic hemangioma of the right hepatic lobe was suspected. Right hepatectomy and total hysterectomy with bilateral ovariectomy was performed. The histological examination of the surgical specimens confirmed the extremely giant cavernous hepatic hemangioma, and a synchronous pT1a endometrioid endometrial adenocarcinoma was also diagnosed. The patient remains alive without postoperative disorders, 6 months after surgery. To our knowledge, this is the first reported case of such huge hemangioma incidentally diagnosed in an obese female, with a synchronous endometrial adenocarcinoma of the uterus. Because obesity may cause hyperestrogenism, it might both increase the growth rate of hemangioma and the genesis of endometrial cancer in perimenopausal females. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  17. Are bilateral cavernous hemangiomas of the orbit rare entities? The role of MRI in a retrospective study

    Energy Technology Data Exchange (ETDEWEB)

    Paonessa, Amalia [Department of Neuroradiology, S.Salvatore Hospital, University of L' Aquila, L' Aquila (Italy)], E-mail: apaonessa7@hotmail.com; Limbucci, Nicola; Gallucci, Massimo [Department of Neuroradiology, S.Salvatore Hospital, University of L' Aquila, L' Aquila (Italy)

    2008-05-15

    Cavernous hemangioma is a benign orbital extraocular vascular lesion consisting of large dilated venous channels with fibrous, well-delineated capsule and hemosiderin deposition. Cavernous hemangioma is considered to be almost always unilateral and bilateral cases have been rarely described. The aim of our study is to evaluate imaging characteristics of cavernous hemangioma and evaluate the prevalence of bilateral cases. We studied 14 patients with cavernous hemangioma of the orbit with surgical confirmation. MRI was performed on a 1.5-T unit before and after contrast agent administration. Each MR examination had been retrospectively evaluated in order to define signal patterns, dimensions, location and other main imaging characteristics. In 3 out of the 14 cases studied (21.4%) bilateral cavernous hemangiomas were found. Thirteen masses appeared isointense on T1, two were hypointense, and two heterogeneous. On T2, 12 were hyperintense, 3 were heterogeneous, 1 isointense, and 1 hypointense. Contrast enhancement was inhomogeneous in 5, homogeneous and intense in 12 cases. The size ranged from 3 mm up to 21 mm (average 14.57). In four patients also CT scan without contrast administration of the orbits was performed. Bilateral cavernous hemangioma appears to be more frequent than as predicted by the literature. In our opinion the main reason of this incongruence is related to technological advances. Our results could also be related to carelessness of radiologists to inspect the other orbit for possible concomitant lesions, and thus invites to major attention in exploring both orbits for eventual bilateral lesions.

  18. Acupuncture in the treatment of infantile colic: a systematic review

    National Research Council Canada - National Science Library

    Mohammadreza Noras; Hamid Reza Bahrami; Roshanak salari

    2017-01-01

    .... The use of acupuncture in infantile colic has increased despite weak evidence. The aim of this paper was to review the literature about safety and efficiency of acupuncture in infantile colic.Methods...

  19. La red sobre trabajo infantil peligroso (Red Tip)

    National Research Council Canada - National Science Library

    Walter Varillas

    2003-01-01

    ...) de la OIT y el Convenio 182 (sobre las peores formas de trabajo infantil), definen como trabajo infantil peligroso el que puede afectar la salud, seguridad y moralidad de los menores. Estudios...

  20. A Giant Hepatic Hemangioma Complicated by Kasabach-Merritt Syndrome: Findings of Tc-99m RBC Scintigraphy and SPECT Including a Total Body Blood Pool Imaging Study

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Myung Hee; Jeong, Hwan Jeong; Lim, Seok Tae; Kim, Dong Wook; Yim, Chang Yeol [Chonbuk National University Medical School, Jeonju (Korea, Republic of)

    2009-02-15

    Kasabach-Merritt syndrome (KMS) consists of thrombocytopenia, microangiopathic hemolytic anemia, and localized consumption coagulopathy that develops within vascular hemangioma. This syndrome may also be associated with occult hemangiomas located at various sites. Tc-99m RBC scintigraphy and SPECT have proven to be reliable for confirming or excluding hemangioma. Total body blood pool imaging study during the scintigraphy also provides a means of screening for occult lesions. The authors report the case of a 29-year-old man who presented with a giant hepatic hemangioma complicated by KMS, and underwent Tc-99m RBC scintigraphy and SPECT including a total body blood pool imaging study.