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Sample records for helle sikka ene

  1. Mr Devraj Sikka

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1984 Section: Earth & Planetary Sciences. Sikka, Mr Devraj M.Sc. (Agra). Date of birth: 1 March 1932. Date of death: 18 March 2017. Specialization: Monsoon, Tropical & Satellite Meteorology, Climate Change, Dynamics of Himalayan Glaciers and Climate Research Last known address: 40, Mausam ...

  2. Arupärimine rahandusministrile eurokalkulaatoritest / Jürgen Ligi, Ene Ergma, Helle Kalda...[jt.

    Index Scriptorium Estoniae

    2011-01-01

    Riigikogu liikmete Helle Kalda, Toomas Vareki, Aivar Riisalu, Lauri Laasi, Mailis Repsi, Enn Eesmaa, Kalle Laaneti, Eldar Efendijevi, Nelli Privalova, Vladimir Velmani, Olga Sõtniku, Kalev Kallo, Toivo Tootseni, Arvo Sarapuu, Nikolai Põdramägi Evelyn Sepa, Ain Seppiku ja Valeri Korbi poolt 17. novembril esitatud arupärimine

  3. Pengembangan Bahan Ajar Menulis Berbagai Jenis Teks Bertema Kearifan Lokal Sikka Bagi Siswa SMP

    Directory of Open Access Journals (Sweden)

    Robertus Adi Sarjono Owon

    2017-05-01

    ABSTRAC Writing is language skills in which integrated preached with the third other skills. In curriculum 2013, the learning done based on the text, but the sources of teaching materials still limited on students’ book published by Department of Education National. So that, it’s needed to developed teaching materials Writing Various Type of Text Themed Local Wisdom of Sikka Regency, NTT by Using Contextual Approach for The Junior High School Student. This research is aims to (1 identify prototype teaching materials writing various type of text themed Sikka local wisdom as students’ and teacher’s needed, (2 knowing the result of prototype expediency writing various type themed Sikka local wisdom in terms of and the contents of, and (3 knowing the effectiveness writing teaching materials to improving the learner’s ability in writing. This research is R& D. The data are collected by using questionnaire to identifies the necessity of teaching materials and to examine prototype expediency of teaching materials. Besides the data also are collected from Students’ result of study toward the ability in writing text themed Sikka local wisdom to examine effectiveness of product. This research indicates that (1 prototype teaching materials writing various type of text themed Sikka local wisdom by using contextual approach based on students’ and teacher’s necessity included:  text model, structure of the text, strategy of writing development, exercises, rating directive and supplement EYD. There is also contextual approach integrated in learning process, (2 the rating result of validation expert on the average score is 77, 45 (good mean while the rating result of validation user average score is 85, 53 (excellent and (3 teaching materials writing text effectively can develop the ability of students’ writing shown by the percentage of students’ classical completeness 80% in groups and 80% students can develop the text based on structure, content, spelling

  4. Riwayat gizi buruk masa lalu (stunted tidak berhubungan dengan prestasi belajar siswa SD di Kabupaten Sikka Nusa Tenggara Timur

    Directory of Open Access Journals (Sweden)

    Tobianus Hasan

    2016-08-01

    Full Text Available ABSTRACTBackground: The main nutritional problem existed in Sikka District was high prevalence of stunting in children (49.6%. Sikka District Health Office data at 2009 and 2010 confirmed that Mego Subdistrict was categorized as area in which the citizens (particularly infants had high risk experiencing health and nutritionissues with percentage of 43.3 in 2009 and 42.3 in 2010. Elementary school student’s passing percentage at Mego Subdistrict in education year of 2009/2010 placed in rank of 15 of 21 subdistricts in Sikka District.Objectives: To determine the association between history of malnutrition (stunted and academic achievement of elementary school students at Sikka District, NTT.Methods: This was an observational study with cross sectional study design. Sample of this research were 3rd grade elementary school students who met inclusive and exclusive criteria. Bivariate and multivariate analysis was used ini this research.Results: Research result showed that bivariatelly stunted condition affects study achievement (p=0.027. External factors affecting study achievement was mother’s education (p=0.001, father’s education (p=0.001 and child’s intelligence (p=0.027. Multivariatelly, most affective factor in student’s study achievement at Mego Subdistrict was parent’s education. The most dominant factor affecting elementary student’s study achievement was mother’s education (p=0.001.Conclusions: Most students suffering stunted had low study achievement (87.2% and stunted had no significant relation to study achievement. Student’s study achievement was affected by parent’s education.KEYWORDS: stunted, study achievementABSTRAKLatar belakang: Masalah gizi utama yang ada di Kabupaten Sikka adalah tingginya balita dengan status pendek dan sangat pendek yang mencapai 49,6%. Data Dinas Kesehatan Kabupaten Sikka tahun 2009 dan 2010 menyatakan bahwa Kecamatan Mego dikategorikan sebagai wilayah dengan masyarakat

  5. Needs Assesment of Cocoa Business Development Using the Value Chain Approach & National Movement of Cocoa Production and Quality Improvement (GERNAS KAKAO): Case Study on Sikka Regency, East Nusa Tenggara

    OpenAIRE

    Ig. Sigit Murwito; Sri Mulyati

    2013-01-01

    The objectives of this study are as follows: 1) Describe the general picture of cocoa in Sikka Regency; 2) Analyze the problems that occur in any cocoa business value chain in Sikka Regency; 3) Analyze the action plan for each problem in each of the business climate value chain for the future improvement of cocoa business development value chain in Sikka. Results of this study are expected to provide information about problems and stakeholder analysis in each cocoa value chain...

  6. Ritual and reflexes of lost sovereignty in Sikka, a regency of Flores in eastern Indonesia

    Directory of Open Access Journals (Sweden)

    E.D. Lewis

    2008-12-01

    Full Text Available In 1993 some among the Sikkanese population of the town of Maumere on the north coast of Flores in eastern Indonesia attended a ritual to reconcile the members of two branches of the family of the rajas of Sikka, a dynasty that had once ruled the district. The two branches had fallen out over differences in opinion about the last succession to the office of raja a few years before the end of the rajadom in the late 1950s. A description of the ritual, which was conducted in an urban rather than a village setting, and an analysis of the performance demonstrate much about the persistence of elements of the old Sikkanese religion in modern Sikkanese society. The contemporary Sikkanese are Christians and the regency of Sikka is part of the modern Indonesian nation-state.

  7. K Mbugua The Problem of Hell Revisited pp93-103

    African Journals Online (AJOL)

    K Mbugua

    The Problem of Hell Revisited: Towards a Gentler Theology of Hell 93 ... One who, after He has killed, has authority to cast into hell; yes, I tell you, fear. Him! .... Suppose your spouse or parent or child goes to hell and you go to heaven.

  8. Educational objectives as the basis for successful coping at school / Leida Talts, Ene Mägi, Helle Sikka... [jt.

    Index Scriptorium Estoniae

    2007-01-01

    Artiklis käsitletakse sotsiaalsete ja eetiliste eesmärkide saavutatust kooliminevate laste rühmades ja esimese kooliaasta lõpus. Uurimus tugineb kolmele küsitlusele, mis viidi läbi ajavahemikus 2002-2004

  9. Matemaatika õpimotiivid ja nende kujunemine / Helle Sikka

    Index Scriptorium Estoniae

    Sikka, Helle, 1949-

    2001-01-01

    Õpimotivatsioonist ja selle mõjuteguritest, matemaatika õppimise motiveerimisest. 1999.a. TPÜ algõpetuse õppetooli poolt läbi viidud uuringust Tallinna koolide 2.-6. klasside õpilaste ja klassiõpetajate seas. Uurimuse eesmärgiks oli selgitada õpilaste üldisi õpimotiive, matemaatika õppimise motiive, aineseoseid argieluga, analüüsida nii õpilaste kui õpetajate hinnanguid probleemülesannete lahendamisele

  10. Taevo Gans / Ene Ammer

    Index Scriptorium Estoniae

    Ammer, Ene

    1998-01-01

    Sisearhitekt Taevo Gansist. Tudengipõlvest, selle aja projektidest, sõpruskonnast, tandemist Summatavet & Gans, Venemaa tellimustest, kaastöölistest. Üksinda Hommilkumaal vene tarbekunsti näitusega 1974. a. 1988. a. loodud perefirmast "GaDis" (omanikud Taevo, Helle Gans, Riia Oja), mis nõustab ka "Wermot" mööbli osas. "GaDise" sisekujundusprojektidest, millega Taevo ja Helle Gans tegelevad üheskoos

  11. Andeka lapse arengukeskkond ja toimetulek koolis / Helle Sikka

    Index Scriptorium Estoniae

    Sikka, Helle

    2001-01-01

    Andekuse mõistest ja selle arengust, andeka lapse isiksuseomadustest. 1998-2000.a. läbi viidud küsitlusuuringust, mille eesmärgiks oli selgitada andekate laste koolimeeldivust, hinnanguid õpetajatele, õpilaste asendit kaaslaste seas, õpilaste arvamusi oma isiksuseomaduste kohta ning andekate harrastusi ja huvisid

  12. Microbial synthesis of alka(enes

    Directory of Open Access Journals (Sweden)

    Weihua eWang

    2013-10-01

    Full Text Available Alka(enes are the predominant constituents of gasoline, diesel, and jet fuels. They can be produced naturally by a wide range of microorganisms. Bio- alka(enes can be used as drop-in biofuels. To date, five microbial pathways that convert free fatty acids or fatty acid derivatives into alka(enes have been identified or reconstituted. The discoveries open a door to achieve microbial production of alka(enes with high efficiency. The modules derived from these alka(ene biosynthetic pathways can be assembled as biological parts and synthetic biology strategies can be employed to optimize the metabolic pathways and improve alka(ene production.

  13. Maurice Car̊me'i lihtsad laulud lastele / Helle Michelson

    Index Scriptorium Estoniae

    Michelson, Helle, 1929-

    2003-01-01

    Car̊me, Maurice. Muinasjutud Caprine'ile / tõlkinud Helle Michelson. [Tallinn] : Tiritamm, 2002 ; Car̊me, Maurice. Naeruhull kirsipuu : [luuletused] / prantsuse keelest tõlkinud Helvi Jürisson. [Tallinn] : Tiritamm, 2002 ; Car̊me, Maurice. Margareetapäev : [jutustused] / tõlkinud Helle Michelson. [Tallinn] : Varrak, 2000

  14. A Visual Narration of Hells in Buddhism and Islam

    Directory of Open Access Journals (Sweden)

    Ary Budianto

    2011-10-01

    Full Text Available The visualization of the Hell’s Tortures both in Buddhism and in Islam is exactly similar. However, their kind of ‘theological’ tendencies may result different outcome. By comparing the visual narration of the Buddhism and Islamic comic books dealing with hell illustrations, I made an‘imaginary’ dialogue between the concept and visuality of hells tortures that exist in both traditions, and see the impact on how far a sincere dialogue could be achieved in these two religious people. During this comparison, I found that both Buddhism and Islam in Java had ever made such an interesting dialogue.Keywords: Hell tortures, Islam-Buddhism comparison, encounter of Java-IndonesiaDOI: 10.15408/ref.v13i1.995

  15. ENES the European Network for Earth System modelling and its infrastructure projects IS-ENES

    Science.gov (United States)

    Guglielmo, Francesca; Joussaume, Sylvie; Parinet, Marie

    2016-04-01

    The scientific community working on climate modelling is organized within the European Network for Earth System modelling (ENES). In the past decade, several European university departments, research centres, meteorological services, computer centres, and industrial partners engaged in the creation of ENES with the purpose of working together and cooperating towards the further development of the network, by signing a Memorandum of Understanding. As of 2015, the consortium counts 47 partners. The climate modelling community, and thus ENES, faces challenges which are both science-driven, i.e. analysing of the full complexity of the Earth System to improve our understanding and prediction of climate changes, and have multi-faceted societal implications, as a better representation of climate change on regional scales leads to improved understanding and prediction of impacts and to the development and provision of climate services. ENES, promoting and endorsing projects and initiatives, helps in developing and evaluating of state-of-the-art climate and Earth system models, facilitates model inter-comparison studies, encourages exchanges of software and model results, and fosters the use of high performance computing facilities dedicated to high-resolution multi-model experiments. ENES brings together public and private partners, integrates countries underrepresented in climate modelling studies, and reaches out to different user communities, thus enhancing European expertise and competitiveness. In this need of sophisticated models, world-class, high-performance computers, and state-of-the-art software solutions to make efficient use of models, data and hardware, a key role is played by the constitution and maintenance of a solid infrastructure, developing and providing services to the different user communities. ENES has investigated the infrastructural needs and has received funding from the EU FP7 program for the IS-ENES (InfraStructure for ENES) phase I and II

  16. Matemaatika õppimise motiveerimine - võimalused ja tegelikkus / Helle Sikka

    Index Scriptorium Estoniae

    Sikka, Helle

    2001-01-01

    1999/2000.a. õpilaste ja algklassiõpetajate seas läbi viidud küsitlusuuringust, millega selgitati 2.-6. kl. õpilaste matemaatika õpimotiive ja analüüsiti õpetajate ja õpilaste hinnanguid matemaatikatunni erinevatele osadele ning tundides kasutatavate tegevuste ja tööviiside sageduse kohta

  17. Põimunud ajastud vanalinnakodus / Helle Neemre

    Index Scriptorium Estoniae

    Neemre, Helle

    1998-01-01

    Kaasajastatud vanalinnakorter Väike-Karja tänavas. Muljeid ja meenutusi tehtust sisekujundaja Helle Neemrelt. Pildiallkirjad - Jüri Kuuskemaa. Korterist võib leida Hansa-aegseid detaile, regionalistlikku laadi, moodsaid mugavusi kaasaegses kujunduses. Sepised (kardinapuud, trepikäsipuu, kaminariistad, -rest) - sepp Raivo Uus. Paekivist detailid restaureeris KAR Grupp. Diivan ja laud - Mang.

  18. Matemaatika võimalused algkooliõpilase mõtlemise arendamisel / Helle Sikka

    Index Scriptorium Estoniae

    Sikka, Helle

    2000-01-01

    Mõtlemise arendamisest matemaatikatundides, 1996-1997.a. 3.-6. klassi õpilaste seas läbi viidud uurimusest, mille eesmärgid olid diagnoosida õpilaste mõtlemisoskust ja analüüsida õpetajate töö tulemusi õpilaste mõtlemise arendamisel matemaatikatundides

  19. 5 küsimust Ene Läkile / Ene Läkk ; interv. Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2006-01-01

    Ene Läkist, kes on alates 2005. aastast interjööri-, disaini- ja arhitektuuriajakirja "Ruum" peatoimetaja. Ene Läkk, Eesti Sisearhitektide Liidu 2005. a. aastapreemia nominent ajakirjandusliku tegevuse eest, ajakirjast "Ruum". Ill.: 6 värv. vaadet, foto ajakirjanikust

  20. Hydroxylative activity of Aspergillus niger towards androst-4-ene and androst-5-ene steroids.

    Science.gov (United States)

    Świzdor, Alina; Panek, Anna; Milecka-Tronina, Natalia

    2017-10-01

    Aspergillus niger, one of fungal species most frequently used for experimental and industrial-scale biotransformations of various organic compounds, is generally known to transform steroids at 16β position. In this work, application of the strain A. niger KCH910 to bioconversion of dehydroepiandrosterone (DHEA), androstenediol and testosterone is described, with emphasis on the metabolic steps leading to the products. Evidence from this study indicated that incubated 5-ene steroids underwent bioconversion within two metabolic pathways: oxidation by the action of 3β-HSD (3β-hydroxysteroid dehydrogenase) to 4-ene steroids, and minor allylic hydroxylation to epimeric 7-alcohols. Further transformation of the 3-oxo-4-ene metabolites resulted in non-selective 16-hydroxylation. It is the first report on an A. niger strain able to introduce not only 16β- but also 16α-hydroxyl function into steroids. Copyright © 2017. Published by Elsevier Inc.

  1. Ibn Qayyim Al-Jawziyyah and Allameh Tabataba’i on Immortality in Hell

    OpenAIRE

    Janan Izadi; Majid Sadeqi Hasan Abadi; Fatemeh Yusefi kazaj

    2016-01-01

    The Immortality of the people of hell and their eternal torment is one of the most important and complex debates, preoccupying religious scholars of different religions and sects. Each of them has taken a different way based on their intellectual principles of belief to solve this problem and the questions thereof, including how the immortality of the inhabitants of hell hellions and their eternal torment is consistent with the mercy and justice of God. How is it reasonable to endure infinite...

  2. Hybrid Organic/Inorganic Thiol-ene-Based Photopolymerized Networks

    OpenAIRE

    Schreck, Kathleen M.; Leung, Diana; Bowman, Christopher N.

    2011-01-01

    The thiol-ene reaction serves as a more oxygen tolerant alternative to traditional (meth)acrylate chemistry for forming photopolymerized networks with numerous desirable attributes including energy absorption, optical clarity, and reduced shrinkage stress. However, when utilizing commercially available monomers, many thiol-ene networks also exhibit decreases in properties such as glass transition temperature (Tg) and crosslink density. In this study, hybrid organic/inorganic thiol-ene resins ...

  3. Ene Sepp esitles esikteost "Medaljon" / Heli Talinurm

    Index Scriptorium Estoniae

    Talinurm, Heli

    2009-01-01

    Ene Sepp esitles 19. veebruaril Rapla Keskraamatukogus oma raamatut, mis pälvis kolmanda koha Eesti Lastekirjanduse Teabekeskuse ja kirjastuse Tänapäev 2008. aasta noorsooromaani võistlusel. Ly Ehini mõtteid, mida Ene Sepa raamat temas tekitas

  4. EVALUASI KEGIATAN POSYANDU DI KABUPATEN BOJONEGORO, JOMBANG, SIKKA DAN CIANJUR

    Directory of Open Access Journals (Sweden)

    Siswanto Siswanto

    2012-11-01

    Full Text Available Since economic crisis in 1997 there has been a slowdown of community based health services, especially 'posyandu'. The study aims to evaluate 'posyandu' activities with the approach of input, process and output. This is an evaluative study, with the design of a cross-sectional survey. Sample of regencies was selected purposively, i.e. Jombang, Bojonegoro, Sikka and Cianjur Regencies. Each regency was taken 2 health centers, and then 5 villages were selected randomly. Each village was taken 3 'posyandu' randomly as well. Data were collected  by structured questionnaire, in-depth interview and Focus Group Discussion, analyzed in a descriptive way. The study has shown that the largest proportion of posyandu's chief was active household wives, with the education level of elementary, junior and senior high school. The assessment found the lack of posyandu's appliances (weighting scale, scale pants, healthy cards, SKDN graphs, medicines, and posters, the inadequacy of health center's and intersectoral personnel's commitment (supervision of 'posyandu' assigned to village midwives, the decline of five-program posyandu's activities (those routines were underfive weighting, educational food supplementation, and immunization, the 'ecline of posyandu's supporting activities ('BKB', TOGA', 'UKGMD', health fund, etc.. as well as, the low achievemen, of posyandu's targets (seen from SKDN indicators and MCH coverage. The study recommends that central and local government continue to conduct posyandu's revitalization programs, by strengthening input and process aspects for achieving a better population coverage and performance.  Key words: posyandu, evaluative study, input, process, output

  5. Hybrid Organic/Inorganic Thiol-ene-Based Photopolymerized Networks.

    Science.gov (United States)

    Schreck, Kathleen M; Leung, Diana; Bowman, Christopher N

    2011-09-15

    The thiol-ene reaction serves as a more oxygen tolerant alternative to traditional (meth)acrylate chemistry for forming photopolymerized networks with numerous desirable attributes including energy absorption, optical clarity, and reduced shrinkage stress. However, when utilizing commercially available monomers, many thiol-ene networks also exhibit decreases in properties such as glass transition temperature (T(g)) and crosslink density. In this study, hybrid organic/inorganic thiol-ene resins incorporating silsesquioxane (SSQ) species into the photopolymerized networks were investigated as a route to improve these properties. Thiol- and ene-functionalized SSQs (SH-SSQ and allyl-SSQ, respectively) were synthesized via alkoxysilane hydrolysis/condensation chemistry, using a photopolymerizable monomer [either pentaerythriol tetrakis(3-mercaptopropionate) (PETMP) or 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TATATO)] as the reaction solvent. The resulting SSQ-containing solutions (SSQ-PETMP and SSQ-TATATO) were characterized, and their incorporation into photopolymerized networks was evaluated.

  6. Reflecting on Hell in Anticipation of Armageddon: The Impact of Reflection and Adaptation on the Education of the US Army Officer Corps

    Science.gov (United States)

    2016-05-10

    Reflecting on Hell in Anticipation of Armageddon: The Impact of Reflection and...Hell in Anticipation of Armageddon: The Impact of Reflection and Adaptation on the Education of the US Army Officer Corps Sb. GRANT NUMBER Sc...Monograph Title: Reflecting on Hell in Anticipation of Armageddon: The Impact of Reflection and Adaptation on the Education of the US Army Officer Corps

  7. Heaven and Hell at the Paradise Motel

    Directory of Open Access Journals (Sweden)

    Tessa Chudy

    2013-10-01

    Full Text Available This piece is taken from the novel “Heaven and Hell at the Paradise Motel” and the exegesis that together forms my PhD thesis. The three main strands of this thesis are Gothic, Noir and sense of place. The novel, ‘‘Heaven and Hell at the Paradise Motel”, is preoccupied with the natural environment, its subtle seasonal changes and the way the environment impacts on its human inhabitants and how they in turn affect it. The novel is, in a very Gothic sense, haunted by dreams, apparitions and narratives – specifically mini-narratives that reflect the nature of fairy tales, horror stories and urban myths. It contains elements of melodrama, horror, romance. The story follows a deeply dysfunctional family through a seasonal cycle: beginning in Spring and ending once again in Spring. A key focus for both the creative and the theoretical work was the everyday application of the Gothic and Noir – for example a house doesn’t have to be a castle to be haunted; people don’t have to be monsters to be monstrous. The dark, the strange, the sinister and the perverse lurk in the shadows of everyday reality, but also how these elements intertwined within the landscape.

  8. Synthesis of some 16,17-secoandrost-5-ene derivatives

    Directory of Open Access Journals (Sweden)

    Gaković Andrea R.

    2010-01-01

    Full Text Available Starting from 3β-acetoxy-17-oxo-16,17-secoandrost-5-ene-16-nitrile (1, 3β-acetoxy-16,17-secoandrost-5-ene-16-nitrile (4 was synthesized by a three-stage procedure. First, the formyl group of compound 1 was reduced, to yield the alcohol 2. Compound 2 was further transformed to the mesyloxy derivative 3, whose reduction with NaBH3CN gave compound 4. Apart from compound 4 as the main reaction product, two additional products were obtained, for which the GC/MS analysis suggested that they are 8(14 and 14 derivatives of compound 4. Compound 4 was transformed into 3β-hydroxy-16,17-sesoandrost-5-ene-16-nitrile (7, the Oppenauer oxidation of which afforded 3-oxo-16,17-secoandrost-4-ene-16-nitrile (8.

  9. Ene Käpp ali optimizem

    Directory of Open Access Journals (Sweden)

    Dušana Findeisen

    1998-12-01

    Full Text Available Na »Konferenci o vlogi in organizaciji izobraževanja odraslih v času prehoda«, ki je bila novembra lani v Tallinnu, glavnem mestu Estonije, smo srečevali nekaj razsvetljenih obrazov organizatorjev. Med njimi je bila Ene Kapp, kratko pristriženih las, živahnega videza in prodornega glasu. Ene Kapp je neprestano bedela nad nami. Tisti, ki so povezani z estonskim izobraževanjem odraslih, jo poznajo že dolgo. Srečujejo se z njo na ANDRAS-u, estonskem združenju za izobraževanje odraslih.

  10. Thiol-ene/methacrylate systems for mechanical damping

    Science.gov (United States)

    McNair, Olivia; Senyurt, Askim; Wei, Huanyu; Gould, Trent; Piland, Scott; Hoyle, Charles; Savin, Daniel

    2010-03-01

    Ternary thiol-ene-methacrylate (TEMA) networks as materials for mechanical energy damping are unique to the sports world. Using a photoinitiation process, TEMA systems are formed via an initial thiol-ene step-growth mechanism along with traditional radical polymerization of acrylate and ene monomers. Final networks have two-part morphologies: acrylate homopolymer sectors imbedded in a multi-component mesh. Several (TEMA) systems have been synthesized and analyzed via thermal and mechanical probing. Initial studies on these ternary systems have shown excellent properties compared to traditional ethylene vinyl alcohol (EVA) copolymers. For example, PEMA networks exhibit glass transition temperatures 33 K higher than EVA, resulting in improved damping at room temperature. This research will help develop relationships between tan delta, glass transition and their effects on mechanical energy damping for ternary (TEMA) systems.

  11. 5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry.

    Science.gov (United States)

    Kaminskyy, Danylo; Kryshchyshyn, Anna; Lesyk, Roman

    2017-11-10

    The presented review is an attempt to summarize a huge volume of data on 5-ene-4-thiazolidinones being a widely studied class of small molecules used in modern organic and medicinal chemistry. The manuscript covers approaches to the synthesis of 5-ene-4-thiazolidinone derivatives: modification of the C5 position of the basic core; synthesis of the target compounds in the one-pot or multistage reactions or transformation of other related heterocycles. The most prominent pharmacological profiles of 5-ene derivatives of different 4-thiazolidinone subtypes belonging to hit-, lead-compounds, drug-candidates and drugs as well as the most studied targets have been discussed. Currently target compounds (especially 5-en-rhodanines) are assigned as frequent hitters or pan-assay interference compounds (PAINS) within high-throughput screening campaigns. Nevertheless, the crucial impact of the presence/nature of C5 substituent (namely 5-ene) on the pharmacological effects of 5-ene-4-thiazolidinones was confirmed by the numerous listed findings from the original articles. The main directions for active 5-ene-4-thiazolidinones optimization have been shown: i) complication of the fragment in the C5 position; ii) introduction of the substituents in the N3 position (especially fragments with carboxylic group or its derivatives); iii) annealing in complex heterocyclic systems; iv) combination with other pharmacologically attractive fragments within hybrid pharmacophore approach. Moreover, the utilization of 5-ene-4-thiazolidinones in the synthesis of complex compounds with potent pharmacological application is described. The chemical transformations cover mainly the reactions which involve the exocyclic double bond in C5 position of the main core and correspond to the abovementioned direction of the 5-ene-4-thiazolidinone modification. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  12. IS-ENES project management - lessons learnt

    Science.gov (United States)

    Parinet, Marie; Guglielmo, Francesca; Joussaume, Sylvie

    2017-04-01

    IS-ENES is the distributed e-infrastructure of models, model data and metadata of the European Network for Earth System Modelling (ENES). It has benefitted from two EC FP7 grants and aims towards further European and national funding to achieve sustainability. We highlight here several challenges related to project management that have risen in the course of these two project-phases spanning 8 years. Some challenges are related to the heterogeneity of the activities within IS-ENES, with different groups working on very diverse activities, not necessarily strictly interdependent. An immediate consequence is the need of implementing and setting up in early phases of the project efficient collection and circulation of information to preserve and reinforce the systemic view of the infrastructure as a whole and the pursuit of common goals, including coordinated provision of services. Toward and beyond such common goals, managing IS-ENES, covering both scientific and more strictly management-related aspects, implies a double-paced approach: besides setting up efficient project workflow, there is the need of setting up longer term objectives. This implies, within the project lifetime, to elaborate and implement a coherent organizational (consistent with scientific goals, funding schemes, research and technology landscape) strategy to pursue these goals beyond the project itself. Furthermore, a series of more generic project management challenges will also be listed and can be gathered around 3 main objectives: ease the internal processes in order to optimize the work, anticipate delays and budget issues, and motivate the project teams by ensuring an efficient internal and external communication.

  13. Multi-chamber and multi-layer thiol-ene microchip for cell culture

    DEFF Research Database (Denmark)

    Tan, H. Y.; Hemmingsen, Mette; Lafleur, Josiane P.

    2014-01-01

    We present a multi-layer and multi-chamber microfluidic chip fabricated using two different thiol-ene mixtures. Sandwiched between the thiol-ene chip layers is a commercially available membrane whose morphology has been altered with coatings of thiol-ene mixtures. Experiments have been conducted ...... with the microchip and shown that the fabricated microchip is suitable for long term cell culture....

  14. War Isn’t Hell, It’s Entertainment: 

    DEFF Research Database (Denmark)

    Schubart, Rikke

    The interdisciplinary anthology War Isn’t Hell, It’s Entertainment analyses the relationship between war and the military on the one hand, and, on the other hand, entertainment, fiction, visual media, and cultural products. It examines war and film stars; war and films; war memorials; war...

  15. Tavatu juhtum / Toomas Rein, Helle Gans, Leonhard Lapin ; interv. Reet Varblane

    Index Scriptorium Estoniae

    Rein, Toomas, 1940-

    2007-01-01

    Arhitektid Toomas Rein ja Leonhard Lapin ning sisearhitekt Helle Gans meenutavad Valgevene näidiskolhoosile Rassvet projekteeritud lasteaeda, mis valmis 1987. aastal. Kompleks pälvis 1987. a. NSVL Arhitektide Liidu preemia ja üleliidulise ametiühingupreemia

  16. Preparation and Preliminary Dielectric Characterization of Structured C60-Thiol-Ene Polymer Nanocomposites Assembled Using the Thiol-Ene Click Reaction

    Directory of Open Access Journals (Sweden)

    Hanaa M. Ahmed

    2015-11-01

    Full Text Available Fullerene-containing materials have the ability to store and release electrical energy. Therefore, fullerenes may ultimately find use in high-voltage equipment devices or as super capacitors for high electric energy storage due to this ease of manipulating their excellent dielectric properties and their high volume resistivity. A series of structured fullerene (C60 polymer nanocomposites were assembled using the thiol-ene click reaction, between alkyl thiols and allyl functionalized C60 derivatives. The resulting high-density C60-urethane-thiol-ene (C60-Thiol-Ene networks possessed excellent mechanical properties. These novel networks were characterized using standard techniques, including infrared spectroscopy (FTIR, differential scanning calorimetry (DSC, dynamic mechanical analysis (DMA, and thermal gravimetric analysis (TGA. The dielectric spectra for the prepared samples were determined over a broad frequency range at room temperature using a broadband dielectric spectrometer and a semiconductor characterization system. The changes in thermo-mechanical and electrical properties of these novel fullerene-thiol-ene composite films were measured as a function of the C60 content, and samples characterized by high dielectric permittivity and low dielectric loss were produced. In this process, variations in chemical composition of the networks were correlated to performance characteristics.

  17. Highly tailorable thiol-ene based emulsion-templated monoliths

    DEFF Research Database (Denmark)

    Lafleur, J. P.; Kutter, J. P.

    2014-01-01

    The attractive surface properties of thiol-ene polymers combined with their ease of processing make them ideal substrates in many bioanalytical applications. We report the synthesis of highly tailorable emulsion-templated porous polymers and beads in microfluidic devices based on off-stoichiometr......The attractive surface properties of thiol-ene polymers combined with their ease of processing make them ideal substrates in many bioanalytical applications. We report the synthesis of highly tailorable emulsion-templated porous polymers and beads in microfluidic devices based on off......-stoichiometry thiolene chemistry. The method allows monolith synthesis and anchoring inside thiol-ene microchannels in a single step. Variations in the monomer stoichiometric ratios and/or amount of porogen used allow for the creation of extremely varied polymer morphologies, from foam-like materials to dense networks...

  18. Surface functionalized thiol-ene waveguides for fluorescence biosensing in microfluidic devices

    DEFF Research Database (Denmark)

    Feidenhans'l, Nikolaj Agentoft; Lafleur, Josiane P.; Jensen, Thomas Glasdam

    2013-01-01

    -ene waveguides were fabricated from 40% excess thiol thiol-ene to ensure the presence of thiol functional groups at the surface of the waveguide. Biotin alkyne was photografted at specific locations using a photomask, directly at the interface between the microfluidic channel and the thiol-ene waveguide prior...

  19. God, Heaven and Hell : The Philosophy of Belief | Asekhauno | Ilorin ...

    African Journals Online (AJOL)

    While heaven is God's promised reward for all who accept Christ and do His will, hell is the abode for all who denounce him. To merit heaven, one is required to renounce worldliness and love God in one's neighbour. While many are undecided, some others remain confused about the reality or otherwise of both the ...

  20. Hell revisited: A socio-critical enquiry into the roots and relevance of ...

    African Journals Online (AJOL)

    p1243322

    emotional reaction to hell – those with the greatest ability to empathise have the biggest ... 1998:141). God will overcome every remnant of evil and all rational creatures ..... of Jesus' message was taken up and intensified by many in the Jesus.

  1. GAMBARAN DISTRIBUSI RABIES DI KABUPATEN SIKKA PROVINSI NUSA TENGGARA TIMUR 2004-2008

    Directory of Open Access Journals (Sweden)

    Fridolina Mau

    2013-09-01

    Full Text Available AbstractRabies has long been known as one of the major public healht problems in Sikka district, East Nusa Tenggara Province,Indonesia. Flores is an isolated preveiously rabies- free. It started with the importation of three dogs from rabies endemicSulawesi in September 1997. The rabies virus is present in the saliva of infected animals; all warm-blooded animals aresusceptible to rabies, and some may serve as natural reservoirs of the virus. Rabies is still a problem for world healthincluding Indonesia. Data of deathcase of rabies (lyssa in Indonesia register 125 cases each year. Rabies in Indonesia is aserious health problem because almost fatal after clinical symptom of the disease with death rate of 100%. Since 2004 toDecember 2009 rabies spread to 24 provinces in East Nusa Tenggara Province. Number of cases due to bite of a mad dogwas 16.000 cases. The aim of this study is to know distribution of rabies casse and the main control measures isimmunizing dogs. Tipe of this study is cross sectional. The result of this study showed the improvement in the last five years(2004 until August 2008 of the occurences of dog bite in cases and human deaths highest in 128 cases (32,48% incommunity health centers Waipare and population dog highest in Kewapante subdistrict 7213 (26,27% although thecoverage of immunization was very low that was 2523 (10,77% out of 6210 population. In average the dog bite casesoccurred in April.Key Word; Description, Distribution, Rabies

  2. Evaluation of Cultural and Ideological Manipulations in Four Persian Translations of Jhumpa Lahiri’s Hell-Heaven

    Directory of Open Access Journals (Sweden)

    Zeinab Kaveyaninia

    2017-10-01

    Full Text Available The present paper examined cultural and ideological implications in translation studies. For  this purpose, four Persian translations of Hell-Heaven were chosen. Hell-Heaven is a story adopted from “Unaccustomed Earth” (2008, written by the Indian-American writer, Jhumpa Lahiri.  Therefore, the translations were explored to detect translators’ ideological shifts; in the way that all components of translations were pondered to detect translational adaptations chosen by four translators. The result showed that translators had adopted translational strategies such as addition, deletion and substitution to deal with American and Indian’s cultural and ideological differences.

  3. Fabrication and bonding of thiol-ene-based microfluidic devices

    DEFF Research Database (Denmark)

    Sikanen, Tiina M; Lafleur, Josiane P.; Moilanen, Maria-Elisa

    2013-01-01

    In this work, the bonding strength of microchips fabricated by thiol-ene free-radical polymerization was characterized in detail by varying the monomeric thiol/allyl composition from the stoichiometric ratio (1:1) up to 100% excess of thiol (2:1) or allyl (1:2) functional groups. Four different...... properties for each application. Here, a capillary electrophoresis separation is performed to demonstrate the attractive properties of stoichiometric thiol-ene microchips....

  4. Evaluation and Control of Thiol-ene/Thiol-epoxy Hybrid Networks.

    Science.gov (United States)

    Carioscia, Jacquelyn A; Stansbury, Jeffrey W; Bowman, Christopher N

    2007-03-08

    The development of thiol-ene/thiol-epoxy hybrid networks offers the advantage of tailorable polymerization kinetics while producing a highly crosslinked, high T(g) polymer that has significantly reduced shrinkage stress. Stoichiometric mixtures of pentaerythritol tetra(3-mercaptopropionate) (PETMP)/triallyl-1,3,5-triazine-2,4,6-trione (TATATO) (thiol-ene, mixture 1) and PETMP/bisphenol a diglycidyl ether (BADGE) (thiol-epoxy, mixture 2) were prepared and hybrid mixtures of 75/25, 50/50, 25/75, and 10/90 w/w of mixtures 1 and 2 were polymerized using a combination of both radical and anionic initiation. The light exposure timing and the relative initiation conditions of the two types were used to control the order and relative rates of the radical and anionic polymerizations. The 50/50 w/w thiol-ene/thiol-epoxy hybrid material exhibited a final stress of only 0.2 MPa, which is 90 % lower than the stress developed in a control dimethacrylate resin. Kinetic analysis indicates composition affects network development in thiol-ene/thiol-epoxy hybrid networks and produces materials with robust mechanical properties.

  5. Fabrication and bonding of thiol-ene-based microfluidic devices

    International Nuclear Information System (INIS)

    Sikanen, Tiina M; Moilanen, Maria-Elisa; Lafleur, Josiane P; Zhuang, Guisheng; Jensen, Thomas G; Kutter, Jörg P

    2013-01-01

    In this work, the bonding strength of microchips fabricated by thiol-ene free-radical polymerization was characterized in detail by varying the monomeric thiol/allyl composition from the stoichiometric ratio (1:1) up to 100% excess of thiol (2:1) or allyl (1:2) functional groups. Four different thiol-ene to thiol-ene bonding combinations were tested by bonding: (i) two stoichiometric layers, (ii) two layers bearing complementary excess of thiols and allyls, (iii) two layers both bearing excess of thiols, or (iv) two layers both bearing excess of allyls. The results showed that the stiffness of the cross-linked polymer plays the most crucial role regarding the bonding strength. The most rigid polymer layers were obtained by using the stoichiometric composition or an excess of allyls, and thus, the bonding combinations (i) and (iv) withstood the highest pressures (up to the cut-off value of 6 bar). On the other hand, excess of thiol monomers yielded more elastic polymer layers and thus decreased the pressure tolerance for bonding combinations (ii) and (iii). By using monomers with more thiol groups (e.g. tetrathiol versus trithiol), a higher cross-linking ratio, and thus, greater stiffness was obtained. Surface characterization by infrared spectroscopy confirmed that the changes in the monomeric thiol/allyl composition were also reflected in the surface chemistry. The flexibility of being able to bond different types of thiol-enes together allows for tuning of the surface chemistry to yield the desired properties for each application. Here, a capillary electrophoresis separation is performed to demonstrate the attractive properties of stoichiometric thiol-ene microchips. (technical note)

  6. Small-x resummation from HELL

    Energy Technology Data Exchange (ETDEWEB)

    Bonvini, Marco [University of Oxford, Rudolf Peierls Centre for Theoretical Physics, Oxford, England (United Kingdom); Marzani, Simone [University at Buffalo, The State University of New York, Buffalo, NY (United States); Peraro, Tiziano [The University of Edinburgh, Higgs Centre for Theoretical Physics, School of Physics and Astronomy, Edinburgh, Scotland (United Kingdom)

    2016-11-15

    Small-x logarithmic enhancements arising from high-energy gluon emissions affect both the evolution of collinearly-factorized parton densities and partonic coefficient functions. With the higher collider energy reached by the LHC, the prospect of a future high-energy collider, and the recent deep-inelastic scattering (DIS) results at small-x from HERA, providing phenomenological tools for performing small-x resummation has become of great relevance. In this paper we discuss a framework to perform small-x resummation for both parton evolution and partonic coefficient functions and we describe its implementation in a computer code named High-Energy Large Logarithms (HELL). We present resummed and matched results for the DGLAP splitting functions and, as a proof of principle, for the massless structure functions in DIS. Furthermore, we discuss the uncertainty from subleading terms on our results. (orig.)

  7. Investigations of thiol-modified phenol derivatives for the use in thiol-ene photopolymerizations.

    Science.gov (United States)

    Reinelt, Sebastian; Tabatabai, Monir; Fischer, Urs Karl; Moszner, Norbert; Utterodt, Andreas; Ritter, Helmut

    2014-01-01

    Thiol-ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol-ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate) (PETMP), is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-modified bis- and trisphenol derivatives in thiol-ene photopolymerizations. For this, six different thiol-modified bis- and trisphenol derivatives exhibiting four to six thiol groups are synthesized via the radical addition of thioacetic acid to suitable allyl-modified precursors and subsequent hydrolysis. Compared to PETMP better flexural strength and modulus of elasticity are achievable in thiol-ene photopolymerizations employing 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione (TATATO) as the ene derivative. Especially, after storage in water, the flexural strength and modulus of elasticity is twice as high compared to the PETMP reference system.

  8. Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations

    Science.gov (United States)

    Reinelt, Sebastian; Tabatabai, Monir; Fischer, Urs Karl; Moszner, Norbert; Utterodt, Andreas

    2014-01-01

    Summary Thiol–ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol–ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate) (PETMP), is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-modified bis- and trisphenol derivatives in thiol–ene photopolymerizations. For this, six different thiol-modified bis- and trisphenol derivatives exhibiting four to six thiol groups are synthesized via the radical addition of thioacetic acid to suitable allyl-modified precursors and subsequent hydrolysis. Compared to PETMP better flexural strength and modulus of elasticity are achievable in thiol–ene photopolymerizations employing 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione (TATATO) as the ene derivative. Especially, after storage in water, the flexural strength and modulus of elasticity is twice as high compared to the PETMP reference system. PMID:25161731

  9. Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations

    Directory of Open Access Journals (Sweden)

    Sebastian Reinelt

    2014-07-01

    Full Text Available Thiol–ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol–ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate (PETMP, is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-modified bis- and trisphenol derivatives in thiol–ene photopolymerizations. For this, six different thiol-modified bis- and trisphenol derivatives exhibiting four to six thiol groups are synthesized via the radical addition of thioacetic acid to suitable allyl-modified precursors and subsequent hydrolysis. Compared to PETMP better flexural strength and modulus of elasticity are achievable in thiol–ene photopolymerizations employing 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione (TATATO as the ene derivative. Especially, after storage in water, the flexural strength and modulus of elasticity is twice as high compared to the PETMP reference system.

  10. Teine muutuva keele ettekandepäev / Helle Metslang, Ilona Tragel

    Index Scriptorium Estoniae

    Metslang, Helle, 1950-

    2007-01-01

    Teisest muutuva keele ettekandepäevast Tartus, 3.11.2006. Muutuva keele ettekandepäevi korraldab ETF-i kahe grandiprojekti töörühm: "Eesti keele grammatilise süsteemi muutumine ja selle põhjused : keelemuutuste analüüs kasutuskontekstis" (Tartu Ülikool, grandihoidja Ilona Tragel) ja "Eesti keele grammatika ja sõnavara dünaamika 1990-2000. aastatel" (Tallinna Ülikool, grandihoidja Helle Metslang)

  11. Hell revisited: A socio-critical enquiry into the roots and relevance of ...

    African Journals Online (AJOL)

    for certain concepts in particular contexts and circumstances, as they are all utilitarian concepts which are employed and abandoned as needs change and sentiments shift. This article will investigate the rise of the concept of hell by investigating the ancient sources in which it first appeared, in order to establish what factors ...

  12. Evaluation and Control of Thiol-ene/Thiol-epoxy Hybrid Networks

    OpenAIRE

    Carioscia, Jacquelyn A.; Stansbury, Jeffrey W.; Bowman, Christopher N.

    2007-01-01

    The development of thiol-ene/thiol-epoxy hybrid networks offers the advantage of tailorable polymerization kinetics while producing a highly crosslinked, high Tg polymer that has significantly reduced shrinkage stress. Stoichiometric mixtures of pentaerythritol tetra(3-mercaptopropionate) (PETMP)/triallyl-1,3,5-triazine-2,4,6-trione (TATATO) (thiol-ene, mixture 1) and PETMP/bisphenol a diglycidyl ether (BADGE) (thiol-epoxy, mixture 2) were prepared and hybrid mixtures of 75/25, 50/50, 25/75, ...

  13. Rapid and simple preparation of thiol-ene emulsion-templated monoliths and their application as enzymatic microreactors

    DEFF Research Database (Denmark)

    Lafleur, Josiane P; Senkbeil, Silja; Novotny, Jakub

    2015-01-01

    A novel, rapid and simple method for the preparation of emulsion-templated monoliths in microfluidic channels based on thiol-ene chemistry is presented. The method allows monolith synthesis and anchoring inside thiol-ene microchannels in a single photoinitiated step. Characterization by scanning...... electron microscopy showed that the methanol-based emulsion templating process resulted in a network of highly interconnected and regular thiol-ene beads anchored solidly inside thiol-ene microchannels. Surface area measurements indicate that the monoliths are macroporous, with no or little micro...

  14. Ene-Liis Semper : hindan päeva, kui teen ühte asja / Ene-Liis Semper ; interv. Jaanus Kulli

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2008-01-01

    Teatri- ja videokunstnik Ene-Liis Semper oma elust ja tööst. Lisaks repliik "Parim päev on tööst prii päev" ja peagi Teater NO99s esietenduvast William Shakespeare'i lavastusest "Muinasjutuline "Perikles"

  15. With Dante in Hell on 9/11: "That Day We Read No Further"

    Science.gov (United States)

    Rosenstein, Roy

    2015-01-01

    In this article, Roy Rosenstein shares the events that occurred during his first day of teaching the Dante and Medieval Culture course in the fall semester of 2001 at the American University of Paris (AUP). On, September 11, 2001, immediately following Rosenstein's opening statement of "Welcome to hell," the class was alerted to the…

  16. On the reaction of the nitroso group with olefins. Mechanisms of ene reactions

    International Nuclear Information System (INIS)

    Seymour, C.A.; Greene, F.D.

    1982-01-01

    Intra- and intermolecular isotope effects point to a two-step process for the reaction of pentafluoronitrosobenzene with tetramethylethylene to afford the ene product, rate-determining formation of an intermediate (for which the arizidine N-oxide is suggested) followed by C-H (or C-D) cleavage to the ene product

  17. Antibiofouling hybrid dendritic Boltorn/star PEG thiol-ene cross-linked networks.

    Science.gov (United States)

    Bartels, Jeremy W; Imbesi, Philip M; Finlay, John A; Fidge, Christopher; Ma, Jun; Seppala, Jonathan E; Nystrom, Andreas M; Mackay, Michael E; Callow, James A; Callow, Maureen E; Wooley, Karen L

    2011-06-01

    A series of thiol-ene generated amphiphilic cross-linked networks was prepared by reaction of alkene-modified Boltorn polyesters (Boltorn-ene) with varying weight percent of 4-armed poly(ethylene glycol) (PEG) tetrathiol (0-25 wt%) and varying equivalents of pentaerythritol tetrakis(3-mercaptopropionate) (PETMP) (0-64 wt%). These materials were designed to present complex surface topographies and morphologies, with heterogeneity of surface composition and properties and robust mechanical properties, to serve as nontoxic antibiofouling coatings that are amenable to large-scale production for application in the marine environment. Therefore, a two-dimensional matrix of materials compositions was prepared to study the physical and mechanical properties, over which the compositions spanned from 0 to 25 wt% PEG tetrathiol and 0-64 wt% PETMP (the overall thiol/alkene (SH/ene) ratios ranged from 0.00 to 1.00 equiv), with both cross-linker weight percentages calculated with respect to the weight of Boltorn-ene. The Boltorn-ene components were prepared through the esterification of commercially available Boltorn H30 with 3-butenoic acid. The subsequent cross-linking of the Boltorn-PEG-PETMP films was monitored using IR spectroscopy, where it was found that near-complete consumption of both thiol and alkene groups occurred when the stoichiometry was ca. 48 wt% PETMP (0.75 equiv SH/ene, independent of PEG amount). The thermal properties of the films showed an increase in T(g) with an increase in 4-armed PEG-tetrathiol wt%, regardless of the PETMP concentration. Investigation of the bulk mechanical properties in dry and wet states found that the Young's modulus was the greatest at 48 wt% PETMP (0.75 equiv of SH/ene). The ultimate tensile strength increased when PETMP was constant and the PEG concentration was increased. The Young's modulus was slightly lower for wet films at constant PEG or constant PETMP amounts, than for the dry samples. The nanoscopic surface features were

  18. A Study of Functional Polymer Colloids Prepared Using Thiol-Ene/Yne Click Chemistry

    Science.gov (United States)

    Durham, Olivia Z.

    This project demonstrates the first instance of thiol-ene chemistry as the polymerization method for the production of polymer colloids in two-phase heterogeneous suspensions, miniemulsions, and emulsions. This work was also expanded to thiol-yne chemistry for the production of polymer particles containing increased crosslinking density. The utility of thiol-ene and thiol-yne chemistries for polymerization and polymer modification is well established in bulk systems. These reactions are considered 'click' reactions, which can be defined as processes that are both facile and simple, offering high yields with nearly 100% conversion, no side products, easy product separation, compatibility with a diverse variety of commercially available starting materials, and orthogonality with other chemistries. In addition, thiol-ene and thiol-yne chemistry follow a step-growth mechanism for the development of highly uniform polymer networks, where polymer growth is dependent on the coupling of functional groups. These step-growth polymerization systems are in stark contrast to the chain-growth mechanisms of acrylic and styrenic monomers that have dominated the field of conventional heterogeneous polymerizations. Preliminary studies evaluated the mechanism of particle production in suspension and miniemulsion systems. Monomer droplets were compared to the final polymer particles to confirm that particle growth occurred through the polymerization of monomer droplets. Additional parameters examined include homogenization energy (mechanical mixing), diluent species and concentration, and monomer content. These reactions were conducted using photoinitiation to yield particles in a matter of minutes with diameters in the size range of several microns to hundreds of microns in suspensions or submicron particles in miniemulsions. Improved control over the particle size and size distribution was examined through variation of reaction parameters. In addition, a method of seeded suspension

  19. Surface modification of cyclomatrix polyphosphazene microsphere by thiol-ene chemistry and lectin recognition

    International Nuclear Information System (INIS)

    Chen, Chen; Zhu, Xue-yan; Gao, Qiao-ling; Fang, Fei; Huang, Xiao-jun

    2016-01-01

    Graphical abstract: A new synthetic route leading to polyphosphazene cyclomatrix microsphere with various functional groups has achieved via thiol-ene click modification. Herein, hexacholorocyclophosphazene (HCCP) crosslinked with bisphenol-S and 4,4′-diallyl bisphenol-S to generate broadly dispersed microspheres. Thiol-ene modification under UV irradiation not only presented high efficiency and flexibility for post-functionalization, but also imposed no harm on global morphology and crosslinked skeleton of such microspheres. - Highlights: • Functional polyphosphazene microspheres with high chemical flexibility were synthesized by thiol-ene modification. • Polyphosphazene microspheres possessed high thermal stability. • Glycosylated polyphosphazene microspheres showed affinity to lectin Con-A, which inferred potential application in biomedicine. - Abstract: A new synthetic route leading to functional polyphosphazene cyclomatrix microsphere has been developed via thiol-ene click modification. Hexacholorocyclophosphazene (HCCP) was crosslinked with both bisphenol-S and 4,4′-diallyl bisphenol-S to obtain vinyl polyphosphazene microspheres (VPZM) in order to ensure high crosslinking degree and introduce vinyl moieties. Compared to the microspheres obtained by HCCP and bisphenol-S, the size of VPZM was broadly dispersed from 400 nm to 1.40 μm. Thiol-ene click reactions were carried out to attach functional groups, such as glucosyl, carboxyl, ester and dodecyl groups onto polyphosphazene microspheres, which demonstrated no change in morphology and size after modification. Solid state NMR (SSNMR) and Fourier transform infrared spectoscopy (FT-IR) results showed that the vinyl moieties were introduced in the period of crosslinking and functionalization was also successful via click reactions. Moreover, the microspheres presented a little difference in thermal properties after modification. Concanavalin A (Con-A) fluorescent adsorption was also observed for

  20. Surface modification of cyclomatrix polyphosphazene microsphere by thiol-ene chemistry and lectin recognition

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chen; Zhu, Xue-yan; Gao, Qiao-ling; Fang, Fei; Huang, Xiao-jun, E-mail: hxjzxh@zju.edu.cn

    2016-11-30

    Graphical abstract: A new synthetic route leading to polyphosphazene cyclomatrix microsphere with various functional groups has achieved via thiol-ene click modification. Herein, hexacholorocyclophosphazene (HCCP) crosslinked with bisphenol-S and 4,4′-diallyl bisphenol-S to generate broadly dispersed microspheres. Thiol-ene modification under UV irradiation not only presented high efficiency and flexibility for post-functionalization, but also imposed no harm on global morphology and crosslinked skeleton of such microspheres. - Highlights: • Functional polyphosphazene microspheres with high chemical flexibility were synthesized by thiol-ene modification. • Polyphosphazene microspheres possessed high thermal stability. • Glycosylated polyphosphazene microspheres showed affinity to lectin Con-A, which inferred potential application in biomedicine. - Abstract: A new synthetic route leading to functional polyphosphazene cyclomatrix microsphere has been developed via thiol-ene click modification. Hexacholorocyclophosphazene (HCCP) was crosslinked with both bisphenol-S and 4,4′-diallyl bisphenol-S to obtain vinyl polyphosphazene microspheres (VPZM) in order to ensure high crosslinking degree and introduce vinyl moieties. Compared to the microspheres obtained by HCCP and bisphenol-S, the size of VPZM was broadly dispersed from 400 nm to 1.40 μm. Thiol-ene click reactions were carried out to attach functional groups, such as glucosyl, carboxyl, ester and dodecyl groups onto polyphosphazene microspheres, which demonstrated no change in morphology and size after modification. Solid state NMR (SSNMR) and Fourier transform infrared spectoscopy (FT-IR) results showed that the vinyl moieties were introduced in the period of crosslinking and functionalization was also successful via click reactions. Moreover, the microspheres presented a little difference in thermal properties after modification. Concanavalin A (Con-A) fluorescent adsorption was also observed for

  1. Episodic nature of the delta 4-ene and delta 5-ene steroidogenic pathways and their relationship to the adreno-gonadal axis in stallions.

    Science.gov (United States)

    Ganjam, V K

    1979-01-01

    Changes in the daily secretory patterns of testosterone and other 17 beta-hydroxyandrogen, total oestrogens and total corticoids were investigated in 7 stallions. Pulsatile fluctuations in plasma hormone levels were found in the serial blood samples collected hourly for 24 h in all animals. The plasma profiles indicated that corticoids, oestrogens and androgens were secreted episodically at all times in stallions. A significant correlation was observed between the precursor and products of delta 4-ene and delta 5-ene pathways and in inverse correlation (r = -0.68; P less than 0.01) was observed between total androgens and total corticoids. The significance of these episodic fluctuations of the major steroid hormones are discussed.

  2. Kandidaadid : Ene Ergma versus Toomas Hendrik Ilves

    Index Scriptorium Estoniae

    2006-01-01

    Artiklis vastatakse küsimustele, kes oleksid Kadriorus Ene Ergma ja Toomas Hendrik Ilvese nõunikud, millist sõnumit kannaks nende esimene iseseisvuspäeva kõne, kuidas nad tähistaksid oma võitu presidendivalimistel, kellele nad annaksid Maarjamaa Risti, kuhu nad teeksid oma esimese välisvisiidi

  3. ANALISIS FAKTOR – FAKTOR PEMILIHAN PEMENANG LELANG JASA KONSTRUKSI PADA PROYEK PEMERINTAH DI KABUPATEN SIKKA

    Directory of Open Access Journals (Sweden)

    Gaudensius Nong Pio

    2015-07-01

    Full Text Available This study aims to determine the factors that influence the selection of the winning bidder in the construction of government projects in Sikka district and determine the most dominant factors. The sample in this study was 57 respondents. Sampling was conducted using a non-probability sampling technique with purposive sampling. Data analysis was performed by factor analysis.   The results of the study obtained 4 factors that influenced the selection of the winning bidder with 84.004% cumulative variance. Factors that influenced were the dominant factor I from 15 variables namely, completeness and suitability of substantial terms requested in the bidding documents; the experience of the company/contractor; bank reference/support of banks; completeness and availability as well as the number of different types of tools/equipment/construction equipment; the availability of education and experience of personnel/field project staff; relationship/ proximity to the project owner; the validity and completeness of the offer letter; the validity of a business license; a contractor offers had to be the lowest prices and the detailed points were competitively priced; meeting tax obligations; the company was not in the custody of the court and was not included in the black list; the contractor would follow and respond quickly to requests; instructions and orders of the project owner for the repair/construction design changes; originality, suitability and validity of bid security letters; methods and strategies for the use and control of the work; the contractor completed the work in accordance with the quality required and in accordance with the specifications of the contract price.

  4. Tandem Wittig-ene reaction approach to kainic acid

    Digital Repository Service at National Institute of Oceanography (India)

    Majik, M.S.; Parameswaran, P.S.; Tilve, S.G.

    The first example of a tandem Wittig-intramolecular ene reaction approach and its application toward the synthesis of kainic acid is reported. The synthetic pathway involves conversion of prenyl bromide into phosphorane 3, followed by one-pot Wittig...

  5. Functionalization of embedded thiol-ene waveguides for evanescent wave induced fluorescence detection in a microfluidic device

    DEFF Research Database (Denmark)

    Feidenhans'l, Nikolaj Agentoft; Jensen, Thomas Glasdam; Lafleur, Josiane P.

    2013-01-01

    We demonstrate the use of functional surface groups inherently present on off-stoichiometric thiol−ene polymers, for site-specific immobilization of biomolecules and detection by evanescent wave-induced fluorescence. An optofluidic chip featuring an embedded thiol−ene waveguide was selectively...... functionalized with biotin using photografting. The biotin was used for immobilization of fluorescently labelled streptavidin, and experiments revealed a linear correlation between streptavidin concentration and fluorescent intensity. To further demonstrate the attractiveness of using thiol−ene for optofluidic...

  6. Politicians, Patriots and Plotters: Unlikely Debates Occasioned by Maximilian Hell's Venus Transit Expedition of 1769

    Science.gov (United States)

    Kontler, Laszlo

    2013-05-01

    This paper discusses the cultural and political contexts and reception of the most important by-product of Maximilian Hell's famous Venus transit expedition of 1768-69, the Demonstratio. Idioma Ungarorum et Lapponum idem esse (1770) by Hell's associate Janos Sajnovics. Now considered a landmark in Finno-Ugrian linguistics, the Demonstratio addressed an academic subject that was at that time almost destined to be caught up in an ideological battlefield defined by the shifting relationship between the Habsburg government, the Society of Jesus, and the Hungarian nobility. The "enlightened absolutist" policies of the former aimed at consolidating the Habsburg monarchy as an empire, at the expense of privileged groups, including religious orders as well as the noble estates. In the situation created by the 1773 suppression of the Jesuit order (a signal of declining patronage from the dynasty), the growing preoccupation on the part of ex-Jesuits like Hell and Sajnovics with "things Hungarian" could have been part of an attempt to re-situate themselves on the Central European map of learning. At the same time, the founding document of this interest, the Demonstratio, evoked violent protests from the other target of Habsburg policies, the Hungarian nobility, because its basic assumptions - the kinship of the Hungarian and the Sami (Lappian) language - potentially undermined the noble ideology of social exclusiveness, established on the alleged "Scythian" ancestry of Hungarians. By exploring the complex motives, intentions, reactions and responses of the chief agents in this story, it is possible to highlight the extra-scientific constraints and facilitators for the practice of knowledge in late eighteenth century Central Europe.

  7. Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations

    OpenAIRE

    Sebastian Reinelt; Monir Tabatabai; Urs Karl Fischer; Norbert Moszner; Andreas Utterodt; Helmut Ritter

    2014-01-01

    Summary Thiol–ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol–ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate) (PETMP), is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-m...

  8. An academic with ambition / Ene Ergma ; interv. Kadri Kukk

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2006-01-01

    Intervjuus Riigikogu asespiikriga käsitletakse kõrghariduse korraldust, professorite rohkust kõrgkoolides, võimalikku kandideerimist Tartu ülikooli rektori kohale, omandatud poliitilisi kogemusi ning ajude äravoolu Eestist. Ene Ergma CV

  9. Tiffany Diamonds and Classical Music as Influences on the Performance of "Don Juan in Hell".

    Science.gov (United States)

    Johnson, Jim

    This paper analyzes Paul Gregory's 1951 production of "Don Juan in Hell," now considered to be a seminal work in the development of professional and educational readers theatre. The paper contends that the production, which presented a nondramatic work without the usual emphasis on design and spectacle, forced a reexamination of the role…

  10. Sa uurisid ekspressionismi 1960ndatel ja 70ndatel... / Ene Lamp

    Index Scriptorium Estoniae

    Lamp, Ene

    2005-01-01

    2004. a. ilmunud raamatu "Ekspressionism" eest Eesti Kultuurkapitali suure kunstipreemia (100000 kr.) saanud Ene Lamp ekspressionismi tähenduse muutumiset, ekspressionismi rollist eesti kunstis, oma tulevikuplaanidest

  11. Ibn Qayyim Al-Jawziyyah and Allameh Tabataba’i on Immortality in Hell

    Directory of Open Access Journals (Sweden)

    Janan Izadi

    2016-09-01

    Full Text Available The Immortality of the people of hell and their eternal torment is one of the most important and complex debates, preoccupying religious scholars of different religions and sects. Each of them has taken a different way based on their intellectual principles of belief to solve this problem and the questions thereof, including how the immortality of the inhabitants of hell hellions and their eternal torment is consistent with the mercy and justice of God. How is it reasonable to endure infinite torment for limited and finite sins? Does a Merciful God, born a sinful slave forever in the fire of the hereafter? Or  is this not the case and He punishes the sinful people for a limited period of time, whether it is short or long, and then releases them from  torture and provides them with  comfort. There is a difference of opinions on these problems in the works of Ibn Qayyim Al- Jawziyyah Al-Ash͑ari and Allameh Tabataba’i, the Shiite philosopher and commentator.Ibn Qayyim addresses widely and systematically the issue of the immortality of the inhabitants of hell. In fact, he interprets immortality (khulūd as a long time, so that the long fire and scourge annihilate the evil from the souls that evil has mixed in their being.  In his viewpoint God has created human monotheist. If the monotheistic nature of the person is changed by vices, these vices and the corrupted nature can be changed by torment and fire. He quotes in his works the ideas of the believers in immortality in torment and criticizes and rebuts them. Stating so many arguments, Ibn Qayyim Al-Jawziyya tries to deny the immortality and eternality in torment. Interpreting the verses of The Holy Quran on immortality of the inhabitants of hell in torment, Allameh Tabataba’i strongly asserts the immortality principle. He relates the happiness and misery, and good and evil among human beings to the development and appearance of the carnal states and habits they gained in the earthly

  12. The archaeological context of Levantine rock Art in Campo de Hellín (Albacete

    Directory of Open Access Journals (Sweden)

    Gabriel GARCÍA ATIÉNZAR

    2012-03-01

    Full Text Available This work explores the knowledge of human settlement and the Levantine rock Art in a specific geographical context. The spatial reading of these elements allows to present hypotheses on human communities that occupied lands of the Campo de Hellín (Albacete during the first phases of Holocene and how they built a landscape that reflects their social, economic and symbolic needs.

  13. Dinosaur Census Reveals Abundant Tyrannosaurus and Rare Ontogenetic Stages in the Upper Cretaceous Hell Creek Formation (Maastrichtian), Montana, USA

    Science.gov (United States)

    Horner, John R.; Goodwin, Mark B.; Myhrvold, Nathan

    2011-01-01

    Background A dinosaur census recorded during the Hell Creek Project (1999–2009) incorporates multiple lines of evidence from geography, taphohistory, stratigraphy, phylogeny and ontogeny to investigate the relative abundance of large dinosaurs preserved in the Upper Cretaceous Hell Creek Formation of northeastern Montana, USA. Overall, the dinosaur skeletal assemblages in the Hell Creek Formation (excluding lag-influenced records) consist primarily of subadult or small adult size individuals. Small juveniles and large adults are both extremely rare, whereas subadult individuals are relatively common. We propose that mature individuals of at least some dinosaur taxa either lived in a separate geographic locale analogous to younger individuals inhabiting an upland environment where sedimentation rates were relatively less, or these taxa experienced high mortality before reaching terminal size where late stage and often extreme cranial morphology is expressed. Methodology/Principal Findings Tyrannosaurus skeletons are as abundant as Edmontosaurus, an herbivore, in the upper Hell Creek Formation and nearly twice as common in the lower third of the formation. Smaller, predatory dinosaurs (e.g., Troodon and dromaeosaurids) are primarily represented by teeth found in microvertebrate localities and their skeletons or identifiable lag specimens were conspicuously absent. This relative abundance suggests Tyrannosaurus was not a typical predator and likely benefited from much wider food choice opportunities than exclusively live prey and/or specific taxa. Tyrannosaurus adults may not have competed with Tyrannosaurus juveniles if the potential for selecting carrion increased with size during ontogeny. Conclusions/Significance Triceratops is the most common dinosaur and isolated skulls contribute to a significant portion of this census. Associated specimens of Triceratops consisting of both cranial and postcranial elements remain relatively rare. This rarity may be explained

  14. Ene-Liiz Semper. Anton Litvin. Bogdan Mamonov

    Index Scriptorium Estoniae

    2005-01-01

    Veebruaris Madridis toimunud Euroopa kunstilaada ARCO jaoks Vene saatkonna galerii poolt koostatud kunstinäitus TRINITY toimub nüüd Tallinnas Vene saatkonna galeriis. Kuraatorid Masha ja Andrei Melnikovid. Osalevad Ene-Liis Semper videoga ArtVideo, vene kunstnik Bogdan Mamonov maaliseeriaga "Ma kanoniseerisin oma sõpru" ja vene kunstnik Anton Litvin fotoprojektiga "Punktuatsioon". Madridis näitas Semper videot "Nimetu"

  15. Proof of a conjecture of Colliot-Th\\'el\\`ene

    OpenAIRE

    Denef, Jan

    2011-01-01

    We prove a conjecture of Colliot-Th\\'el\\`ene that implies the Ax-Kochen Theorem on p-adic forms. We obtain it as an easy consequence of a diophantine excision theorem whose proof forms the body of the present paper.

  16. preparation of bicyclic lactones using lewis acids catalyzed ene

    African Journals Online (AJOL)

    Administrator

    The synthesis of the cis-fused bicyclic lactones relies extensively on the Lewis acid ... having an allylic hydrogen (an"ene") and a compound containing an electron .... observed that the lithium enolate obtained from 3-methyl-2(5H)- furanone ...

  17. Preparation and Characterization of Fluorinated Hydrophobic UV-Crosslinkable Thiol-Ene Polyurethane Coatings

    Directory of Open Access Journals (Sweden)

    Wenjing Xia

    2017-08-01

    Full Text Available The polyurethane prepolymer terminated with a double bond was synthesized using isophorone diisocyanate (IPDI, hydroxyl terminated polybutadiene (HTPB, 1,4-butanediol (BDO, and 2-hydroxyethyl acrylate (HEA. Then, a series of innovative UV-curable polyurethane coatings were prepared by blending ene-terminated polyurethane, fluoroacrylate monomer, and multifunctional thiol crosslinker upon UV exposure. The incorporation of fluoroacrylate monomer and multifunctional thiols into polyurethane coatings significantly enhanced the hydrophobic property, mechanical property, pencil hardness, and glossiness of the polyurethane coatings. This method of preparing UV crosslinkable, hydrophobic polyurethane coatings based on thiol-ene chemistry exhibited numerous advantages over other UV photocuring systems.

  18. ENE-Mates - A public information program for women

    International Nuclear Information System (INIS)

    Nagashima, Kyoko

    1995-01-01

    Japan depends on import for more than 80 percent of its total energy supply. Nuclear energy is one of the most promising alternatives to oil. It plays a significant role for energy supply in terms of reliability, economic viability and reduction of CO 2 emissions. In order to secure needed capacity, the Government concentrates its efforts on acquiring public acceptance of nuclear power as well as ensuring the safety of plants and improving plant capability and reliability. An opinion poll, done by the Japanese Government in Sep. of 1990, showed that 73.3 percent of man and 57.4 percent of women think that nuclear power is necessary to secure energy supply. Nuclear Power Engineering Corporation (NUPEC) employs various methods for information services arid, in particular, electric power generation including nuclear with an assignment from the Japanese Government. Public information activities by the Nuclear Power Engineering Corporation (NUPEC) are as follows: a) Telephone QA service to respond to public inquiries; b) Publishing the 'Nuclear Newsletter' monthly and various brochures; c) Information service by personal computer network Atomnet concerning energy in general, and operation/trouble informations of nuclear plants; d) Distribution and service of personal computers to local governments offices/museums, etc., for users ranging from children to adults to gather nuclear related information; e) Organization of female monitors 'ENE-MATES' to have lecture meetings and site tours. ENE-MATES - A Public Information Program For Women. As a 1990 opinion poll shows, women's feelings about nuclear energy differ from that of men. Women are more sensitive and anxious than men on nuclear energy issues. To improve this situation several programs for women have been planned and implemented.'ENE-MATES' program is one of these cases. It's purpose is to encourage women, centering around house wives, to have unbiased understanding of energy-related issues

  19. Novel Thiol-Ene Hybrid Coating for Metal Protection

    Directory of Open Access Journals (Sweden)

    Mona Taghavikish

    2016-04-01

    Full Text Available A novel hybrid anticorrosion coating with dual network of inorganic (Si–O–Si and organic bonds (C–S–C was prepared on metal through an in situ sol-gel and thiol-ene click reaction. This novel interfacial thin film coating incorporates (3-mercaptopropyl trimethoxysilane (MPTS and 1,4-di(vinylimidazolium butane bisbromide based polymerizable ionic liquid (PIL to form a thiol-ene based photo-polymerized film, which on subsequent sol-gel reaction forms a thin hybrid interfacial layer on metal surface. On top of this PIL hybrid film, a self-assembled nanophase particle (SNAP coating was employed to prepare a multilayer thin film coating for better corrosion protection and barrier performance. The novel PIL hybrid film was characterised for structure and properties using Fourier transform infrared spectroscopy (FTIR, differential scanning calorimetry (DSC, and thermogravimetric analysis (TGA. The corrosion protection performance of the multilayer coating was examined using potentiodynamic polarization and electrochemical impedance spectroscopy (EIS. The results reveal that this novel double layer coating on metal offers excellent protection against corrosion and has remarkably improved the barrier effect of the coating.

  20. DFT Investigation of the Palladium-Catalyzed Ene-Yne Coupling

    DEFF Research Database (Denmark)

    Henriksen, Signe Teuber; Tanner, David Ackland; Skrydstrup, T.

    2010-01-01

    ). Concerning chemoselectivity, the calculations also clarify why the ene-yne coupling is able to dominate over plausible alternative reaction pathways such as alkene homocoupiing and alkyne polymerization. The role of the phosphine ligand at various stages of the catalytic cycle has also been delineated....

  1. Synthesis and characterization of thiol-ene functionalized siloxanes and evaluation of their polymerization kinetics, network properties, and dental applications

    Science.gov (United States)

    Cole, Megan A.

    We explored formation-structure-property relationships in thiol-ene functionalized oligosiloxanes to create crosslinked networks. Specifically, nine oligomers were synthesized, three with thiol-functional silane repeats and three with allyl-functional silane repeats. Structural variations in each oligomer were systematically induced through the incorporation of non-reactive repeats bearing either diphenyl or di-n-octyl moieties, and the oligomer molecular weight was limited by the presence of monofunctional silane condensation species. The molecular weights and chain compositions of all oligomers were ascertained and subsequently used in the evaluation of network properties formed upon photopolymerization of thiol- and ene-functional reactants. Polymerization kinetics of the thiol-ene functionalized siloxanes were also investigated using photoinitiation owing to the spatial and temporal control afforded by this technique. In particular, the effects of the viscosity of the ene-functionalized oligomer and the degree of thiol functionalization on the observed polymerization rate were determined. Results showed that the speed of polymerization varied with changes to the rate-limiting step, which was heavily influenced by neighboring non-reactive functionalities. Moreover, the thiol-ene reaction was found to exhibity unimolecular termination exclusively in siloxane-based systems. Proposed use of the thiol-ene functionalized siloxane system as a dental impression material necessitated the development of a redox initiation scheme. Evaluation of the benzoylperoxide/dimethyl-p-toluidine redox pair in traditional systems showed bulk thiol-ene polymerizations comparable to photoinitiation with the added advantage of uninhibited depth control, as also demonstrated in small molecule thiol-ene coupling reactions initiated by this same redox system. Application of the redox pair to the siloxane system allowed for the viscoelastic properties as well as the feature replication

  2. Preparation of Biomolecule Microstructures and Microarrays by Thiol–ene Photoimmobilization

    NARCIS (Netherlands)

    Weinrich, Dirk; Köhn, Maja; Jonkheijm, Pascal; Westerlind, Ulrika; Dehmelt, Leif; Engelkamp, Hans; Christianen, Peter C.M.; Kuhlmann, Jürgen; Maan, Jan C.; Nüsse, Dirk; Schröder, Hendrik; Wacker, Ron; Voges, Edgar; Breinbauer, Rolf; Kunz, Horst; Niemeyer, Christof M.; Waldmann, Herbert

    2010-01-01

    A mild, fast and flexible method for photoimmobilization of biomolecules based on the light-initiated thiol–ene reaction has been developed. After investigation and optimization of various surface materials, surface chemistries and reaction parameters, microstructures and microarrays of biotin,

  3. Thiol-ene reaction as tool for crosslinking of polynorbornene micelles in the nanoscale

    Science.gov (United States)

    Rupp, Barbara; Bauer, Thomas; Slugovc, Christian

    2009-08-01

    The thiol-ene reaction is a established photoreaction of multifunctional thiols and enes. Virtually any type of ene will participate in a free radical polymerisation process with a thiol. An advantage over many other photochemical reactions is that the reaction proceeds almost as rapidly in ambient conditions as in inert atmosphere. In this work we introduce the UV-crosslinking of polynorbornenes made by ring opening metathesis polymerization making use of the residual double bond in the polymer backbone. The crosslinking experiments were done in thin films and were followed by FTIR measurements, to proof the accessibility of double-bonds in the polymers for the addition of the thiols. As a result of these pre-experiments we created flexible and light transmitting films. To further increase the scope of this reaction, amphiphilic block copolymers were prepared and used to form block copolymer micelles in a selective solvent, which were subsequently crosslinked with pentaerythritol tetra(3-mercaptopropionate) (PETMP). FT-IR, DLS and SEM-measurements were used to prove the successful crosslinking and thus nanoparticle formation.

  4. Ene ja Tõnis Kask pole valikuga rahul / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2003-01-01

    Eesti Filmiajakirjanike Ühing andis auhinna Aasta film 2002 mängufilmile "Agent Sinikael" : režissöör Marko Raat. Viimane sai preemiaks 12 000 krooni. Auhinna rahastajad omanimelise fondi kaudu Eesti Rahvuskultuuri Fondi juures Ene ja Tõnis Kask peavad "Nimed marmortahvlil" väljajätmist isegi nominentide hulgast shokeerivaks

  5. Orented immobilization of farnesylated proteins by the thiol-ene reaction

    NARCIS (Netherlands)

    Weinrich, Dirk; Lin, Po-Chiao; Jonkheijm, Pascal; Nguyen, Uyen T.T.; Schröder, Hendrik; Niemeyer, Christof M.; Alexandrov, Kirill; Goody, Roger; Waldmann, Herbert

    2010-01-01

    Anchoring the protein: Proteins were immobilized rapidly under mild conditions by thiol-ene photocoupling between S-farnesyl groups attached to a genetically encodable “CAAX-box” tetrapeptide sequence (A is aliphatic) at the C terminus of the protein and surface-exposed thiols (see scheme). This

  6. Uuringud TPÜ algõpetuse õppetoolis : Tallinna Pedagoogikaülikooli algõpetuse õppetool / Helle Sikka, Leida Talts

    Index Scriptorium Estoniae

    Sikka, Helle

    2003-01-01

    Ajavahemikul 1995-2003 on TPÜ algõpetuse õppetoolis publitseeritud õppejõudude ja magistrantide ühistööna kaheksa teaduskogumikku, kusjuures kaks viimast neist on avaldatud koostöös Helsingi Ülikooli õpetajakoolituse osakonna õppejõududega. Seisuga mai 2003 on kaitstud 30 magistritööd, 706 bakalaureuse- ja diplomitööd, mis puudutavad noorema kooliea õpilasi ja õpetajaid

  7. Simple preparation of thiol-ene particles in glycerol and surface functionalization by thiol-ene chemistry (TEC) and surface chain transfer free radical polymerization (SCT-FRP)

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Chiaula, Valeria; Yu, Liyun

    2018-01-01

    functionalization of excess thiol groups via photochemical thiol-ene chemistry (TEC) resulting in a functional monolayer. In addition, surface chain transfer free radical polymerization (SCT-FRP) was used for the first time to introduce a thicker polymer layer on the particle surface. The application potential...

  8. Spray-deposition and photopolymerization of organic-inorganic thiol-ene resins for fabrication of superamphiphobic surfaces.

    Science.gov (United States)

    Xiong, Li; Kendrick, Laken L; Heusser, Hannele; Webb, Jamie C; Sparks, Bradley J; Goetz, James T; Guo, Wei; Stafford, Christopher M; Blanton, Michael D; Nazarenko, Sergei; Patton, Derek L

    2014-07-09

    Superamphiphobic surfaces, exhibiting high contact angles and low contact angle hysteresis to both water and low surface tension liquids, have attracted a great deal attention in recent years because of the potential of these materials in practical applications such as liquid-resistant textiles, self-cleaning surfaces, and antifouling/anticorrosion coatings. In this work, we present a simple strategy for fabricating of superamphiphobic coatings based on photopolymerization of hybrid thiol-ene resins. Spray-deposition and UV photopolymerization of thiol-ene resins containing hydrophobic silica nanoparticles and perfluorinated thiols provide a multiscale topography and low-energy surface that endows the surface with superamphiphobicity. The wettability and chemical composition of the surfaces were characterized by contact-angle goniometry and X-ray photoelectron spectroscopy, respectively. The hierarchical roughness features of the thiol-ene surfaces were investigated with field-emission scanning electron microscopy. Droplet impact and sandpaper abrasion tests indicate the coatings respectively possess a robust antiwetting behavior and good mechanical durability.

  9. The Proud Prime Evil of Hell: Characterization of Satan as the Capital Vice of Pride in Milton’s Paradise Lost

    Directory of Open Access Journals (Sweden)

    David Hazemali

    2016-12-01

    Full Text Available This paper looks into the characterisation of Satan as the Capital Vice of Pride in John Milton’s Paradise Lost. It thus supports the findings of Robert Charles Fox, who in his study The Seven Deadly Sins in Paradise Lost first thoroughly analysed and comprehensively presented this issue and its importance in Milton’s epic. The authors of the study share Fox’s belief that Milton consciously used the system of the Seven Capital Vices in his epic as a structural device to present the entire scope of evil to the willing reader, and he achieved this by giving Satan and six other major denizens of Hell each the characteristics of a particular Vice. In other words, each of the seven major diabolical figures that appear in Paradise Lost embodies or personifies one of the Seven Capital Vices. As the most eloquent and characteristically perfected of the diabolical figures of Hell, Satan embodies Pride, the prime Capital Vice.

  10. La basílica y el baptisterio del Tolmo de Minateda (Hellín, Albacete

    Directory of Open Access Journals (Sweden)

    Abad Casal, Lorenzo

    2000-12-01

    Full Text Available The paper presents a religious complex unearthed in the upper part of the high medieval city of Tolmo de Minateda (Hellín, Albacete, matching the Madînat lyih mentioned by Arab sources. In the authors' opinion, it was the see of Eio, created at the start of the 7th century. The religious complex comprises a basilica with three aisles, a semicircular apse and an adjoining baptistry at the feet of the building, also in three sections. The paper provides a detailed study of the baptistry and of the different remodelling of the baptismal font and theorises on the location of the liturgical space.Se presenta el complejo religioso exhumado en la parte alta de la ciudad altomedieval del Tolmo de Minateda (Hellín, Albacete, correspondiente a la Madînat Iyih de las fuentes árabes y, en opinión de los autores, a la sede episcopal Eiotana/Elotana creada a principios del siglo VII. El conjunto religioso está compuesto por una basílica de tres naves con ábside semicircular y un baptisterio anexo situado a los pies del edificio, también con distribución tripartita. En este artículo se estudia detalladamente el baptisterio, así como las distintas remodelaciones de la piscina bautismal, y se propone una restitución del espacio litúrgico.

  11. Fabrication of Biomolecule Microarrays Using Rapid Photochemical Surface Patterning in Thiol-Ene-Based Microfluidic Devices.

    Science.gov (United States)

    Jönsson, Alexander; Lafleur, Josiane P

    2018-01-01

    In many biochip applications, it is advantageous to be able to immobilize biomolecules at specific locations on the surface of solid supports. In this protocol, we describe a photochemical surface patterning procedure based on thiol-ene/yne photochemistry which allows for the simple and rapid selective patterning of biomolecules on thiol-ene solid supports. We describe the preparation of solid supports which are required for the immobilization, including porous monoliths, as well as two different immobilization schemes based on biotin-streptavidin interactions and covalent linkage via free amino groups respectively.

  12. Ene-yne Cross-Metathesis for the Preparation of 2,3-Diaryl-1,3-dienes

    Directory of Open Access Journals (Sweden)

    Meriem K. Abderrezak

    2017-11-01

    Full Text Available Ene-yne cross-metathesis from alkynes and ethylene is a useful method to produce substituted conjugated butadiene derivatives. If this method has been used with aliphatic alkynes, it has however never been used starting from diarylacetylenes as internal alkynes. We show that the ene-yne cross-metathesis catalyzed by the second generation Hoveyda ruthenium catalyst provides the 2,3-diarylbuta-1,3-dienes under 3 atm of ethylene at 100 °C. The scope and limitations of the reaction have been evaluated starting from unsymmetrical functionalized diarylacetylene derivatives hence leading to unsymmetrical 2,3-diarylbuta-1,3-dienes in a straightforward and environmentally acceptable manner.

  13. Evaluation of fracture toughness and mechanical properties of ternary thiol-ene-methacrylate systems as resin matrix for dental restorative composites.

    Science.gov (United States)

    Beigi, Saeed; Yeganeh, Hamid; Atai, Mohammad

    2013-07-01

    Study and evaluation of fracture toughness, flexural and dynamic mechanical properties, and crosslink density of ternary thiol-ene-methacrylate systems and comparison with corresponding conventional methacrylate system were considered in the present study. Urethane tetra allyl ether monomer (UTAE) was synthesized as ene monomer. Different formulations were prepared based on combination of UTAE, BisGMA/TEGDMA and a tetrathiol monomer (PETMP). The photocuring reaction was conducted under visible light using BD/CQ combination as photoinitiator system. Mechanical properties were evaluated via measuring flexural strength, flexural modulus and fracture toughness. Scanning electron microscopy (SEM) was utilized to study the morphology of the fractured specimen's cross section. Viscoelastic properties of the samples were also determined by dynamic mechanical thermal analysis (DMTA). The same study was performed on a conventional methacrylate system. The data were analyzed and compared by ANOVA and Tukey HSD tests (significance level=0.05). The results showed improvement in fracture toughness of the specimens containing thiol-ene moieties. DMTA revealed a lower glass transition temperature and more homogenous structure for thiol-ene containing specimens in comparison to the system containing merely methacrylate monomer. The flexural modulus and flexural strength of the specimens with higher thiol-ene content were lower than the neat methacrylate system. The SEM micrographs of the fractured surface of specimens with higher methacrylate content were smooth and mirror-like (shiny) which represent brittle fracture. The thiol-ene-methacrylate system can be used as resin matrix of dental composites with enhanced fracture toughness in comparison to the methacrylate analogous. Copyright © 2013 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  14. Chalcogenidobis(ene-1,2-dithiolate)molybdenum(IV) complexes (chalcogenide E = O, S, Se): probing Mo≡E and ene-1,2-dithiolate substituent effects on geometric and electronic structure.

    Science.gov (United States)

    Sugimoto, Hideki; Tano, Hiroyuki; Suyama, Koichiro; Kobayashi, Tomoya; Miyake, Hiroyuki; Itoh, Shinobu; Mtei, Regina P; Kirk, Martin L

    2011-02-07

    New square-pyramidal bis(ene-1,2-dithiolate)MoSe complexes, [Mo(IV)Se(L)(2)](2-), have been synthesised along with their terminal sulfido analogues, [Mo(IV)S(L)(2)](2-), using alkyl (L(C(4)H(8))), phenyl (L(Ph)) and methyl carboxylate (L(COOMe)) substituted dithiolene ligands (L). These complexes now complete three sets of Mo(IV)O, Mo(IV)S and Mo(IV)Se species that are coordinated with identical ene-1,2-dithiolate ligands. The [alkyl substituted Mo(S/Se)(L(C(4)H(8)))(2)](2-) complexes were reported in prior investigations (H. Sugimoto, T. Sakurai, H. Miyake, K. Tanaka and H. Tsukube, Inorg. Chem. 2005, 44, 6927, H. Tano, R. Tajima, H. Miyake, S. Itoh and H. Sugimoto, Inorg. Chem. 2008, 47, 7465). The new series of complexes enable a systematic investigation of terminal chalcogenido and supporting ene-1,2-dithiolate ligand effects on geometric structure, electronic structure, and spectroscopic properties. X-ray crystallographic analysis of these (Et(4)N)(2)[MoEL(2)] (E = terminal chalocogenide) complexes reveals an isostructural Mo centre that adopts a distorted square pyramidal geometry. The M≡E bond distances observed in the crystal structures and the ν(M≡E) vibrational frequencies indicate that these bonds are weakened with an increase in L→Mo electron donation (L(COOMe) < L(Ph) < L(C(4)H(8))), and this order is confirmed by an electrochemical study of the complexes. The (77)Se NMR resonances in MoSeL complexes appear at lower magnetic fields as the selenido ion became less basic from MoSeL(C(4)H(8)), MoSeL(Ph) and MoSeL(COOMe). Electronic absorption and resonance Raman spectroscopies have been used to assign key ligand-field, MLCT, LMCT and intraligand CT bands in complexes that possess the L(COOMe) ligand. The presence of low-energy intraligand CT transition in these MoEL(COOMe) compounds directly probes the electron withdrawing nature of the -COOMe substituents, and this underscores the complex electronic structure of square pyramidal bis(ene-1

  15. Rapid photochemical surface patterning of proteins in thiol-ene based microfluidic devices

    DEFF Research Database (Denmark)

    Lafleur, Josiane P.; Kwapiszewski, Radoslaw; Jensen, Thomas Glasdam

    2013-01-01

    ! 17 SH nm"2. Biotin alkyne was patterned directly inside thiol–ene microchannels prior to conjugation with fluorescently labelled streptavidin. The surface bound conjugates were detected by evanescent waveinduced fluorescence (EWIF), demonstrating the success of the grafting procedure and its...

  16. Investigations of step-growth thiol-ene polymerizations for novel dental restoratives.

    Science.gov (United States)

    Lu, Hui; Carioscia, Jacquelyn A; Stansbury, Jeffery W; Bowman, Christopher N

    2005-12-01

    The goal of this work was to investigate the feasibility of formulating novel dental restorative materials that utilize a step-growth thiol-ene photopolymerization. Particularly, we are aiming to significantly reduce the polymerization shrinkage and shrinkage stress while retaining adequate physical properties as compared to current dimethacrylatre-based systems. The thiol-ene system is composed of a 4:3 molar mixture of triallyl-1,3,5-triazine-2,4,6-trione (TATATO) and pentaerythritol tetramercaptopropionate (PETMP). The simultaneous measurement of shrinkage stress and functional group conversion was performed. Solvent extraction of unreacted monomers and dynamic mechanical analysis on the polymer networks that were formed were also studied. Flexural strength was measured for both filled and unfilled PETMP/TATATO and Bis-GMA/TEGDMA systems. Photopolymerization of PETMP/TATATO occurs at a much higher rate, with the maximum polymerization rate six times faster, than Bis-GMA/TEGDMA cured under the identical conditions. The results from the simultaneous measurement of shrinkage stress and conversion showed that the onset of shrinkage stress coincides with the delayed gel point conversion, which is predicted to be 41% for the 3:4 stoichiometric PETMP/TATATO resin composition. The maximum shrinkage stress developed for PETMP/TATATO was about 0.4 MPa, which was only approximately 14% of the maximum shrinkage stress of the Bis-GMA/TEGDMA system. Adequate flexural strength and flexural modulus values were obtained for both filled and unfilled PETMP/TATATO systems. The dramatically reduced shrinkage stress, increased polymerization rate, significance increased functional group conversion, and decreased leachable species are all benefits for the use-of thiol-ene systems as potential dental restorative materials.

  17. Heat- and light-induced thiol-ene oligomerization of soybean oil-based polymercaptan

    Science.gov (United States)

    Polymercaptanized soybean oil (PMSO), the product of a thiol-ene reaction between soybean oil and hydrogen sulfide, is a material of interest as a lubricant additive and polymer precursor. We investigated with gel permeation chromatography, nuclear magnetic resonance (one-dimensional and two-dimensi...

  18. Patterned Hydrophilization of Nanoporous 1,2‐PB by Thiol‐ene Photochemistry

    DEFF Research Database (Denmark)

    Berthold, Anton; Sagar, Kaushal Shashikant; Ndoni, Sokol

    2011-01-01

    is monitored by FT‐IR, UV–Vis, contact angle, and gravimetry. Overall quantum yields are calculated for the two thiol‐ene “click” reactions in nano‐confinement, neatly revealing their chain‐like nature. Top–down photolithographic patterning is demonstrated, realizing hydrophilic nanoporous “corridors...

  19. In Predicadores hell. Cautive children

    Directory of Open Access Journals (Sweden)

    Rosa María ARAGÜÉS ESTRAGUÉS

    2012-02-01

    Full Text Available In the city of Zaragoza, on April 6th of 1939, 512 women and 53 children were moved from Torrero’s prison to the Qualified jail of Predicadores. The accumulation, the bad conditions of the building, the punishments, the vexations, the bad supply and the violence did of Predicator’s one of the hardest prison of the postwar period: a real hell. Their only crime in most cases was be mothers, wifes or daughters of republican men. They were denied the right of being political prisoners as they were just considered common prisoners. Since 1939 up to its definitive closing in 1955, a great number of women went through its dependences, some of them with their children, «protected» by the Royal decree of November 14, 1930, where it was established that the small children could join prison with their mothers until they were fulfilling the age of four years. The above mentioned decree would suffer a modification on march 30, 1940, by means of an order of the Department of Justice by which the age of the child was reduced at the age of three. Many of them would not manage to survive, luckier others were put at liberty together with their mothers or delivered to some relative. But there were others who accompanied their mothers in a long periplus, going of jail in jail, until they were three that they were separated from them, join institutions of welfare under the guardianship of the State, or given in adoption without previous assent of their progenitors or legal representatives. All of them, held captive by the victors and labelled red children must go through a long rehabilitation process that became loyal and obedient subjects of the New State.

  20. Photocured thiol-ene based optical fluorescence sensor for determination of gold(III)

    Energy Technology Data Exchange (ETDEWEB)

    Çubuk, Soner, E-mail: sonercubuk@marmara.edu.tr; Kahraman, Memet Vezir; Yetimoğlu, Ece Kök; Kenan, Sibel

    2014-02-17

    Graphical abstract: -- Highlights: •Photopolymerized fluorescence sensor for Au(III) analysis has been developed. •Preparation of polymeric sensor is simple and quick. •Fluorescence sensor used for analysis of Au(III) in real samples. -- Abstract: This study describes the preparation and the characterization of a new thiol-ene based polymeric fluorescence sensor by photo initiated polymerization of trimethylolpropane tris(3-mercaptopropionate), 2-hydroxyethylacrylate, and 2,4,6-triallyloxy-1,3,5-triazine which are used as monomers and also a photo initiator (2,2-dimethoxy-2-phenylacetophenone) for its usage as optical sensor for gold ions. The thiol-ene based polymeric membrane sensor was characterized by using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR) and scanning electron microscopy (SEM). The response characteristics of the sensors including dynamic range, pH effect, response time, and the effect of foreign ions were investigated. Fluorescence spectra showed that the excitation/emission maxima of the membrane were at 379/425 nm, respectively.

  1. Photocured thiol-ene based optical fluorescence sensor for determination of gold(III)

    International Nuclear Information System (INIS)

    Çubuk, Soner; Kahraman, Memet Vezir; Yetimoğlu, Ece Kök; Kenan, Sibel

    2014-01-01

    Graphical abstract: -- Highlights: •Photopolymerized fluorescence sensor for Au(III) analysis has been developed. •Preparation of polymeric sensor is simple and quick. •Fluorescence sensor used for analysis of Au(III) in real samples. -- Abstract: This study describes the preparation and the characterization of a new thiol-ene based polymeric fluorescence sensor by photo initiated polymerization of trimethylolpropane tris(3-mercaptopropionate), 2-hydroxyethylacrylate, and 2,4,6-triallyloxy-1,3,5-triazine which are used as monomers and also a photo initiator (2,2-dimethoxy-2-phenylacetophenone) for its usage as optical sensor for gold ions. The thiol-ene based polymeric membrane sensor was characterized by using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR) and scanning electron microscopy (SEM). The response characteristics of the sensors including dynamic range, pH effect, response time, and the effect of foreign ions were investigated. Fluorescence spectra showed that the excitation/emission maxima of the membrane were at 379/425 nm, respectively

  2. Divergent Effects of Beliefs in Heaven and Hell on National Crime Rates

    Science.gov (United States)

    Shariff, Azim F.; Rhemtulla, Mijke

    2012-01-01

    Though religion has been shown to have generally positive effects on normative ‘prosocial’ behavior, recent laboratory research suggests that these effects may be driven primarily by supernatural punishment. Supernatural benevolence, on the other hand, may actually be associated with less prosocial behavior. Here, we investigate these effects at the societal level, showing that the proportion of people who believe in hell negatively predicts national crime rates whereas belief in heaven predicts higher crime rates. These effects remain after accounting for a host of covariates, and ultimately prove stronger predictors of national crime rates than economic variables such as GDP and income inequality. Expanding on laboratory research on religious prosociality, this is the first study to tie religious beliefs to large-scale cross-national trends in pro- and anti-social behavior. PMID:22723927

  3. Divergent effects of beliefs in heaven and hell on national crime rates.

    Directory of Open Access Journals (Sweden)

    Azim F Shariff

    Full Text Available Though religion has been shown to have generally positive effects on normative 'prosocial' behavior, recent laboratory research suggests that these effects may be driven primarily by supernatural punishment. Supernatural benevolence, on the other hand, may actually be associated with less prosocial behavior. Here, we investigate these effects at the societal level, showing that the proportion of people who believe in hell negatively predicts national crime rates whereas belief in heaven predicts higher crime rates. These effects remain after accounting for a host of covariates, and ultimately prove stronger predictors of national crime rates than economic variables such as GDP and income inequality. Expanding on laboratory research on religious prosociality, this is the first study to tie religious beliefs to large-scale cross-national trends in pro- and anti-social behavior.

  4. Interview: Professor Helle Neergaard, President of the European Council for Small Business and Entrepreneurship, on the Nature of Creativity, Innovation and Entrepreneurship

    Science.gov (United States)

    Industry and Higher Education, 2015

    2015-01-01

    On August 13, 2014, Rita G. Klapper conducted a Skype interview with Helle Neergaard. Neergaard is not only President of the European Council for Small Business and Entrepreneurship, but also Docent at the Hanken School of Economics, and Professor at iCARE, Department of Business Administration, School of Business and Social Sciences, University…

  5. The Toledo Qur’ān and Islamic Eschatology: Translating the Names of Hell in Aljamiado Literature

    Directory of Open Access Journals (Sweden)

    Tottoli, Roberto

    2014-12-01

    Full Text Available The introduction of the Toledo Qur’ān states that the text in the Latin alphabet was copied from an Aljamiado translation. In fact, the translation of terms and expressions relating to hell shows some specific characteristics of Aljamiado literature, such as the privileged use of calques from Arabic and a preference for the term Jahannam, though the most quoted term al-nār (“fuego” is also attested. These characteristics are more evident when compared to Latin translations prior or contemporaneous to the Toledo Qur’ān. It is clear that in the translation of terms related to hell, these works display greater attention to Latin style and final result thus evidencing another perspective and consequently another audience. The preference given to the term Jahannam is closely linked to the evidence emerging from the Aljamiado eschatological literature, where Jahannam is generally preferred to al-nār/ “fuego.” This preference reflects more than specific characteristics of the literature of the Moriscos, an evolution of Muslim literature as a whole, which is reflected in the kind of literary materials circulating and trasmitted. Futher, along with this, Aljamiado literature on hell and also the Toledo Qur’ān reflect similar developments in the late medieval Muslim Arabic literature, and therefore also in eschatological traditions, in which Jahannam emerges strongly as the term used to describe hell in narratives.La introducción del Corán de Toledo dice que el texto en alfabeto latino se copió de una traducción aljamiada. De hecho, la traducción de términos y expresiones relacionadas con el infierno muestra algunas características muy especiales de la literatura aljamiada, como la preferencia por el uso de calcos del árabe o del término Ŷahannam, aunque el término más citado, al-nār (“fuego”, está también atestiguado. Estas características son incluso más evidentes cuando se comparan con las traducciones latinas

  6. Rapid photochemical surface patterning of proteins in thiol-ene based microfluidic devices

    DEFF Research Database (Denmark)

    Lafleur, Josiane P.; Kwapiszewski, Radoslaw; Jensen, Thomas Glasdam

    2012-01-01

    ” and “ene” monomers present in the microfluidic chip bulk material provides a simple and efficient way of tuning the chip’s surface chemistry. Here, thiol-ene chips displaying an excess of functional thiol groups at their surfaces are functionalized with biotin and streptavidin in a controlled fashion using...

  7. Superhydrophobic hybrid inorganic-organic thiol-ene surfaces fabricated via spray-deposition and photopolymerization.

    Science.gov (United States)

    Sparks, Bradley J; Hoff, Ethan F T; Xiong, Li; Goetz, James T; Patton, Derek L

    2013-03-13

    We report a simple and versatile method for the fabrication of superhydrophobic inorganic-organic thiol-ene coatings via sequential spray-deposition and photopolymerization under ambient conditions. The coatings are obtained by spray-deposition of UV-curable hybrid inorganic-organic thiol-ene resins consisting of pentaerythritol tetra(3-mercaptopropionate) (PETMP), triallyl isocyanurate (TTT), 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (TMTVSi), and hydrophobic fumed silica nanoparticles. The spray-deposition process and nanoparticle agglomeration/dispersion provide surfaces with hierarchical morphologies exhibiting both micro- and nanoscale roughness. The wetting behavior, dependent on the concentration of TMTVSi and hydrophobic silica nanoparticles, can be varied over a broad range to ultimately provide coatings with high static water contact angles (>150°), low contact angle hysteresis, and low roll off angles (spray-deposition and UV-cure process on a variety of substrate surfaces including glass, paper, stone, and cotton fabric.

  8. Preliminary Engineering Report contaminated groundwater seeps 317/319/ENE area

    International Nuclear Information System (INIS)

    1996-01-01

    When the Resource Conservation and Recovery Act Facility Investigation (RFI) in the 317/319/ENE Area of Argonne National Laboratory-East (ANL-E) was being completed, groundwater was discovered moving to the surface through a series of seeps. The seeps are located approximately 600 ft south of the ANL fence line in Waterfall Glen Forest Preserve. Samples of this water were collected and analyzed for selected parameters. Two of five seeps sampled were found to contain detectable levels of organic contaminants. Three chemical species were identified: chloroform (14-25 μg/L), carbon tetrachloride (56-340 μg/L), and tetrachloroethylene (3-6 μg/L). The other seeps did not contain detectable levels of volatile organic compounds (VOCs). The water issuing from these two contaminated seeps flows into a narrow ravine, where it is visible as a trickle of water flowing through sand and gravel deposits on the floor of the ravine. Approximately 100-ft downstream of the seep area, the contaminated water is no longer visible, having drained back into the soil in the bed of the ravine. Figure 1 shows the location of the 317/319/ENE Area in relation to the ANL-E site and the Waterfall Glen Forest Preserve

  9. Stereoselectivity in ene reactions with 1O2: matrix effects in polymer supports, photo-oxygenation of organic salts and asymmetric synthesis.

    Science.gov (United States)

    Griesbeck, Axel G; Bartoschek, Anna; Neudörfl, Jörg; Miara, Claus

    2006-01-01

    The ene reaction of chiral allylic alcohols is applied as a tool for the investigation of intrapolymer effects by means of the stereoselectivity of the singlet-oxygen addition. The diastereo selectivity strongly depends on the structure of the polymer, the substrate loading degree and also on the degree of conversion demonstrating additional supramolecular effects evolving during the reaction. The efficiency and the stability of polymer-bound sensitizers were evaluated by the ene reaction of singlet oxygen with citronellol. The ene reaction with chiral ammonium salts of tiglic acid was conducted under solution phase conditions or in polystyrene beads under chiral contact ion-pair conditions. The products thus obtained precipitate during the photoreaction as ammonium salts. Moderate asymmetric induction was observed for this procedure for the first time.

  10. Synergistic Diazo-OH Insertion/Conia-Ene Cascade Catalysis for the Stereoselective Synthesis of γ-Butyrolactones and Tetrahydrofurans.

    Science.gov (United States)

    Hunter, Arianne C; Schlitzer, Steven C; Sharma, Indrajeet

    2016-11-02

    A novel and highly efficient diazo-OH insertion/Conia-ene cascade reaction of readily available homopropargylic acids and alcohols with diazo carbonyl compounds is described. The cascade reaction involves a synergistic Rh/Ag/Au catalyst cocktail and proceeds instantly with a variety of substituted diazo compounds and acids/alcohols to provide functionalized γ-butyrolactones and tetrahydrofurans with complete regio- and stereoselectivity. The unprecedented rate-enhancement, complete stereoselectivity, and the enabling of new Conia-ene cyclizations suggest a concerted [4+1]-cycloaddition reaction pathway under synergistic (Rh/Ag/Au)-catalysis conditions. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. One-step fabrication of PEGylated fluorescent nanodiamonds through the thiol-ene click reaction and their potential for biological imaging

    Science.gov (United States)

    Huang, Hongye; Liu, Meiying; Tuo, Xun; Chen, Junyu; Mao, Liucheng; Wen, Yuanqing; Tian, Jianwen; Zhou, Naigen; Zhang, Xiaoyong; Wei, Yen

    2018-05-01

    Over the past years, fluorescent carbon nanoparticles have got growing interest for biological imaging. Fluorescent nanodiamonds (FNDs) are novel fluorescent carbon nanoparticles with multitudinous useful properties, including remarkable fluorescence properties, extremely low toxicity and high refractive index. However, facile preparation of FNDs with designable properties and functions from non-fluorescent detonation nanodiamonds (DNDs) has demonstrated to be challengeable. In this work, we reported for the first time that preparation of Polyethylene glycol (PEG) functionalized FNDs through a one-step thiol-ene click reaction using thiol containing PEG (PEG-SH) as the coating agent. Based on the characterization results, we demonstrated that PEG-SH could be efficiently introduced on DNDs to obtain FNDs through the thiol-ene click chemistry. The resultant FND-PEG composites showed high water dispersibility, strong fluorescence and low cytotoxicity. Moreover, FND-PEG composites could be internalized by cells and displayed good cell dyeing performance. All of these features implied that FND-PEG composites are of great potential for biological imaging. Taken together, a facile one-step strategy based on the one-step thiol-ene click reaction has been developed for efficient preparation of FND-PEG composites from non-fluorescent DNDs. The strategy should be also useful for fabrication of many other functional FNDs via using different thiol containing compounds for the universality of thiol-ene click reaction.

  12. Stavovi medicinskih sestara u Hrvatskoj o primarnom oživljavanju prijevremeno rođene novorođenčadi

    OpenAIRE

    Bilić, Iva; Prpić, Igor; Radić, Jelena; Vukelić, Petar; Petrović, Ana; Juretić, Emilija; Furlan, Ivanka

    2008-01-01

    CILJ: Cilj istraživanja bilo je ispitati stavove medicinskih sestara u Hrvatskoj o primarnom oživljavanju prijevremeno rođene djece. METODE: Pisanom anketom ispitivana je dob, roditeljstvo, radno iskustvo i mjesto rada te stavovi medicinskih sestara iz Hrvatske o primarnom oživljavanju prijevremeno rođene djece. Anketirano je 174 medicinskih sestara; 49 zaposlenih u rađaonici ili na mjestima rada sa trudnicama (Rađ/Tr), 79 u pedijatrijskim/ neonatološkim jedinicama intenzivnog liječenja (...

  13. Advantages and drawbacks of Thiol-ene based resins for 3D-printing

    Science.gov (United States)

    Leonards, Holger; Engelhardt, Sascha; Hoffmann, Andreas; Pongratz, Ludwig; Schriever, Sascha; Bläsius, Jana; Wehner, Martin; Gillner, Arnold

    2015-03-01

    The technology of 3D printing is conquering the world and awakens the interest of many users in the most varying of applications. New formulation approaches for photo-sensitive thiol-ene resins in combination with various printing technologies, like stereolithography (SLA), projection based printing/digital light processing (DLP) or two-photon polymerization (TPP) are presented. Thiol-ene polymerizations are known for its fast and quantitative reaction and to form highly homogeneous polymer networks. As the resins are locally and temporally photo-curable the polymerization type is very promising for 3D-printing. By using suitable wavelengths, photoinitiator-free fabrication is feasible for single- and two photon induced polymerization. In this paper divinyl ethers of polyethylene glycols in combination with star-shaped tetrathiols were used to design a simple test-system for photo-curable thiol-ene resins. In order to control and improve curing depth and lateral resolution in 3D-polymerization processes, either additives in chemical formulation or process parameters can be changed. The achieved curing depth and resolution limits depend on the applied fabrication method. While two-/multiphoton induced lithography offers the possibility of micron- to sub-micron resolution it lacks in built-up speed. Hence single-photon polymerization is a fast alternative with optimization potential in sub-10-micron resolution. Absorber- and initiator free compositions were developed in order to avoid aging, yellowing and toxicity of resulting products. They can be cured with UV-laser radiation below 300 nm. The development at Fraunhofer ILT is focusing on new applications in the field of medical products and implants, technical products with respect to mechanical properties or optical properties of 3D-printed objects. Recent process results with model system (polyethylene glycol divinylether/ Pentaerithrytol tetrakis (3-mercaptopropionat), Raman measurements of polymer conversion

  14. Heterofunctional Glycopolypeptides by Combination of Thiol-Ene Chemistry and NCA Polymerization.

    Science.gov (United States)

    Krannig, Kai-Steffen; Schlaad, Helmut

    2016-01-01

    Glycopolypeptides are prepared either by the polymerization of glycosylated amino acid N-carboxyanhydrides (NCAs) or by the post-polymerization functionalization of polypeptides with suitable functional groups. Here we present a method for the in-situ functionalization and (co-) polymerization of allylglycine N-carboxyanhydride in a facile one-pot procedure, combining radical thiol-ene photochemistry and nucleophilic ring-opening polymerization techniques, to yield well-defined heterofunctional glycopolypeptides.

  15. Continuous Flow Science in an Undergraduate Teaching Laboratory: Photocatalytic Thiol-Ene Reaction Using Visible Light

    Science.gov (United States)

    Santandrea, Jeffrey; Kairouz, Vanessa; Collins, Shawn K.

    2018-01-01

    An undergraduate teaching laboratory experiment involving a continuous flow, photocatalytic thiol-ene reaction using visible-light irradiation is described that allows students to explore concepts of green chemistry, photochemistry, photocatalysis, and continuous flow chemistry.

  16. Emplazamiento hacia el ENE del manto de Los Reales (Alpujarrides occidentales: criterios estructurales y de petrofábrica

    Directory of Open Access Journals (Sweden)

    Tubía, J. M.

    1984-08-01

    Full Text Available Los Reales nappe rests over Ojén nappe to the North of Sierra Alpujata. The nappe contact zone shows a intense plastic deformation with mylonitic rocks, The deformation decreases progressively going away from the contacto The structural study of footwall and hangingwall roen permits to attribute this deformation to the Los Reales nappe emplacement over that of Ojén. The foliation and stretching lineation distributions show a WSW-ENE shear direction. The mylonite microstructural characteristics and the enstatite crystalline preferred orientations in the basal peridotites give a mear sense in according that, Los Reales nappe is displaced, in their present position, from the WSW towards the ENE.

    El manto de Los Reales descansa sobre el manto de Ojén, al norte de Sierra Alpujata. La zona de contacto entre mantos exhibe una intensa deformación plástica con rocas miloníticas; la deformación disminuye progresivamente al alejarse del contacto. El estudio estructural de las rocas infra y suprayacentes al contacto permite atribuir esta deformación al emplazamiento del manto de Los Reales sobre el de Ojén. , Las distribuciones de la foliación y de la lineación, de estiramiento indican una dirección de cizallamiento WSW-ENE. Las características microestructurales de las milonitas y las orientaciones preferentes cristalinas de la enstatita en las peridotitas basales proporcionan un sentido de cizallamiento tal que el manto de Los Reales se ha desplazado, en su posición actual, desde el WSW hacia el ENE.

  17. Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis

    KAUST Repository

    Baumgartner, Corinne; Ma, Sandy; Liu, Qi; Stoltz, Brian M.

    2010-01-01

    Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S N2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention

  18. ULYSSES IN THE DIVINE COMEDY – HELL – A COMPARISON OF THE HERO IN DANTE, HOMER AND VIRGIL

    Directory of Open Access Journals (Sweden)

    Alysson Ramos Artuso

    2016-07-01

    Full Text Available Ulysses is a constant character in Western literature and Dante Alighieri was an author that rework him. In the Divine Comedy, Ulysses is in Hell, in the eighth ditch of the eighth circle, corresponding to the fraudsters. In the construction of this character, Dante recovered Ulysses characteristics from Greek and Latin tradition, which is analyzed and compared in this article with the Homer’s and Virgil’s characters. At the end, Ulysses and Dantes - author and character of Comedy – are related.

  19. Preparation and Characterization of Fluorinated Hydrophobic UV-Crosslinkable Thiol-Ene Polyurethane Coatings

    OpenAIRE

    Wenjing Xia; Nianqing Zhu; Rongjie Hou; Wengui Zhong; Mingqing Chen

    2017-01-01

    The polyurethane prepolymer terminated with a double bond was synthesized using isophorone diisocyanate (IPDI), hydroxyl terminated polybutadiene (HTPB), 1,4-butanediol (BDO), and 2-hydroxyethyl acrylate (HEA). Then, a series of innovative UV-curable polyurethane coatings were prepared by blending ene-terminated polyurethane, fluoroacrylate monomer, and multifunctional thiol crosslinker upon UV exposure. The incorporation of fluoroacrylate monomer and multifunctional thiols into polyurethane ...

  20. High performance thiol-ene thermosets based on fully bio-based poly(limonene carbonate)s

    NARCIS (Netherlands)

    Li, C.; Johansson, M.; Sablong, R.J.; Koning, C.E.

    2017-01-01

    High glass transition temperature (Tg) thiol-ene networks (TENs) based on poly(limonene carbonate)s (PLCs), derived from orange oils and of potential degradability are described here. PLCs with moderate molecular weight were prepared by copolymerization of limonene oxide with CO2 and subsequent

  1. ENED-GEM: A Conceptual Framework Model for Psychological Enjoyment Factors and Learning Mechanisms in Educational Games about the Environment

    Science.gov (United States)

    Fjællingsdal, Kristoffer S.; Klöckner, Christian A.

    2017-01-01

    Based on a thorough review of psychological literature, this article seeks to develop a model of game enjoyment and environmental learning (ENvironmental EDucational Game Enjoyment Model, ENED-GEM) and delineate psychological processes that might facilitate learning and inspire behavioral change from educational games about the environment. A critically acclaimed digital educational game about environmental issues (Fate of the World by Red Redemption/Soothsayer Games) was used as a case study. Two hundred forty-nine reviews of the game from the popular gaming and reviewing platform known as Steam were analyzed by means of a thematic content analysis in order to identify key player enjoyment factors believed to be relevant to the process of learning from games, as well as to gain an understanding of positive and negative impressions about the game’s general content. The end results of the thematic analysis were measured up to the suggested ENED-GEM framework. Initial results generally support the main elements of the ENED-GEM, and future research into the importance of these individual core factors is outlined. PMID:28701988

  2. ENED-GEM: A Conceptual Framework Model for Psychological Enjoyment Factors and Learning Mechanisms in Educational Games about the Environment

    Directory of Open Access Journals (Sweden)

    Kristoffer S. Fjællingsdal

    2017-06-01

    Full Text Available Based on a thorough review of psychological literature, this article seeks to develop a model of game enjoyment and environmental learning (ENvironmental EDucational Game Enjoyment Model, ENED-GEM and delineate psychological processes that might facilitate learning and inspire behavioral change from educational games about the environment. A critically acclaimed digital educational game about environmental issues (Fate of the World by Red Redemption/Soothsayer Games was used as a case study. Two hundred forty-nine reviews of the game from the popular gaming and reviewing platform known as Steam were analyzed by means of a thematic content analysis in order to identify key player enjoyment factors believed to be relevant to the process of learning from games, as well as to gain an understanding of positive and negative impressions about the game’s general content. The end results of the thematic analysis were measured up to the suggested ENED-GEM framework. Initial results generally support the main elements of the ENED-GEM, and future research into the importance of these individual core factors is outlined.

  3. ENED-GEM: A Conceptual Framework Model for Psychological Enjoyment Factors and Learning Mechanisms in Educational Games about the Environment.

    Science.gov (United States)

    Fjællingsdal, Kristoffer S; Klöckner, Christian A

    2017-01-01

    Based on a thorough review of psychological literature, this article seeks to develop a model of game enjoyment and environmental learning (ENvironmental EDucational Game Enjoyment Model, ENED-GEM) and delineate psychological processes that might facilitate learning and inspire behavioral change from educational games about the environment. A critically acclaimed digital educational game about environmental issues (Fate of the World by Red Redemption/Soothsayer Games) was used as a case study. Two hundred forty-nine reviews of the game from the popular gaming and reviewing platform known as Steam were analyzed by means of a thematic content analysis in order to identify key player enjoyment factors believed to be relevant to the process of learning from games, as well as to gain an understanding of positive and negative impressions about the game's general content. The end results of the thematic analysis were measured up to the suggested ENED-GEM framework. Initial results generally support the main elements of the ENED-GEM, and future research into the importance of these individual core factors is outlined.

  4. Stories of Hell and Healing: Internet Users' Construction of Benzodiazepine Distress and Withdrawal.

    Science.gov (United States)

    Fixsen, Alison M; Ridge, Damien

    2017-11-01

    Benzodiazepines are a group of drugs used mainly as sedatives, hypnotics, antiepileptics, and muscle relaxants. Consumption is recommended for 2 to 4 weeks only, due to fast onset of dependency and potentially distressing withdrawal symptoms. Few peer-review studies have drawn on the user experiences and language to appreciate firsthand experiences of benzodiazepine withdrawal or discontinuation syndrome. We looked extensively at patient stories of benzodiazepine withdrawal and recovery on Internet support sites and YouTube. Our analysis indicated that users employ rich metaphors to portray the psychologically disturbing and protracted nature of their suffering. We identified seven major themes: hell and isolation, anxiety and depression, alienation, physical distress, anger and remorse, waves and windows, and healing and renewal. By posting success stories, ex-users make known that "healing" can be a long, unpredictable process, but distress does lessen, and recovery can happen.

  5. Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis

    KAUST Repository

    Baumgartner, Corinne

    2010-01-01

    Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S N2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry. © 2010 The Royal Society of Chemistry.

  6. Amino acid-incorporated polymer network by thiol-ene polymerization

    Directory of Open Access Journals (Sweden)

    R. Yokose

    2015-08-01

    Full Text Available Triallyl L-alanine (A3A and triallyl L-phenylalanine (A3F were synthesized by reactions of L-alanine and L-phenylalanine with allyl bromide in the presence of sodium hydroxide, respectively. Thiol-ene thermal polymerization of A3A or A3F with pentaerythritol-based primary tetrathiol (pS4P or pentaerythritol-based secondary tetrathiol (S4P at allyl/SH 1/1 in the presence of 2,2'-azobis(isobutyronitrile produced an amino acid-incorporated polymer network (A3ApS4P, A3A-S4P or A3F-S4P. Although the thermally cured resins were homogeneous and flat films, the corresponding thiol-ene photopolymerization did not give a successful result. Degree of swelling for each thermally cured film in N,Ndimethylformamide was much higher than that in water. The glass transition and 5% weight loss temperatures (Tg and T5 of A3F-pS4P and A3F-S4P were higher than those of A3A-pS4P and A3A-S4P, respectively. Also, A3F-pS4P and A3F-S4P exhibited much higher tensile strengths and moduli than A3A-pS4P and A3A-S4P did, respectively. Consequently, A3FpS4P displayed the highest Tg (38.7°C, T5 (282.0°C, tensile strength (9.5 MPa and modulus (406 MPa among all the thermally cured resins.

  7. Ene-Liis Semper : Kohalolu piiritsoonis = Presence in the border zone / Anu Allas

    Index Scriptorium Estoniae

    Allas, Anu, 1977-

    2007-01-01

    Teatri- ja videokunstnik Ene-Liis Semperi peamiselt 1990-ndate aastate videotest, mis on valdavalt rõhutatult lavastuslikud, paisutatult sümbolistlikud või kus on esitatud piirsituatsioone, ahistust ning selle teadlikku eksponeerimist väljakutsena publikule. Iseennast paljastades, alandades ja ohtu seades jääb kunstnik enamasti jahedalt distantseerituks, publikule jääb aga arusaamatuks, kas tegemist on ohvri, kangelanna või osava mänguriga

  8. Stratigraphy and environments of deposition of the Cretaceous Hell Creek Formation (reconnaissance) and the Paleocene Ludlow Formation (detailed), southwestern North Dakota. Report of investigations No. 56

    International Nuclear Information System (INIS)

    Moore, W.L.

    1976-01-01

    The Cretaceous Hell Creek and Paleocene Ludlow Formations of southwestern North Dakota, with the exception of the included lignite beds and minor amounts of concretions and nodules, are almost exclusively clastic sediments and sedimentary rocks. Massive clays, clays alternating with silts and sands, sandstones filling channels and other depressions, sheet sandstones, and lignites are the dominant sediment and rock types present. These sediments and sedimentary rocks were mostly deposited in a continental environment and were largely alluvial, lacustrine or paludal in origin; though marginal marine deposition, in part, is indicated by the occurrence of brackish water faunas in portions of the upper Ludlow Formation. With the possible exception of a persistent lignite near the base, persistent lignites are not present in the Hell Creek Formation. The Ludlow can be subdivided into several informal units, typically coal-bounded, which can be traced laterally over large areas. This informal subdivision permits isolation of stratigraphic units for the study of local environments of deposition. Channel and depression fill sandstones of the Ludlow Formation have a relatively low permeability and a high organic content at the surface and, for this reason, are considered poor prospective uranium host rocks. The lighter colored yellow winnowed sheet sandstones of the Ludlow are more permeable and relatively free of organic matter. They are considered as possible host rocks for uranium occurring in association with an oxidation/reduction interface at shallow depths. The uranium potential is enhanced where the latter sandstones occur along paleodivides which have been overlain by the Oligocene White River Formation, or in local areas where the latter formation is still preserved. Light yellow winnowed sheet sandstones are rare in the Hell Creek Formation, and the chances for uranium prospects in this interval seem correspondingly reduced

  9. 1-Methoxy-3-o-tolylbicyclo[2.2.2]oct-5-ene-2,2-dicarbonitrile

    Directory of Open Access Journals (Sweden)

    Orhan Büyükgüngör

    2009-09-01

    Full Text Available In the title compound, C18H18N2O, the cyclohexene and cyclohexane rings of the bicyclo[2.2.2]oct-5-ene unit adopt distorted boat conformations. In the crystal, molecules exist as C—H...N hydrogen-bonded centrosymmetric R22(14 dimers, which are further linked by C—H...π interactions.

  10. Professional preparation of teachers - problems and possibilities. The Estonian case / Katrin Poom-Valickis, Ülle Saarits, Helle Sikka... [jt.

    Index Scriptorium Estoniae

    2008-01-01

    Artikkel kirjeldab õpetajakoolituse olukorda Eestis aastal 2003. Aineõpetajate, klassiõpetajate ja koolieelsete lasteasutuste õpetajate ettevalmistusest Tallinna Ülikoolis ning nende karjääriperspektiive tööturul

  11. Thiol-Ene Photo-Click Collagen-PEG Hydrogels: Impact of Water-Soluble Photoinitiators on Cell Viability, Gelation Kinetics and Rheological Properties

    Directory of Open Access Journals (Sweden)

    Róisín Holmes

    2017-06-01

    Full Text Available Thiol-ene photo-click hydrogels were prepared via step-growth polymerisation using thiol-functionalised type-I collagen and 8-arm poly(ethylene glycol norbornene-terminated (PEG-NB, as a potential injectable regenerative device. Type-I collagen was thiol-functionalised by a ring opening reaction with 2-iminothiolane (2IT, whereby up to 80 Abs.% functionalisation and 90 RPN% triple helical preservation were recorded via 2,4,6-Trinitrobenzenesulfonic acid (TNBS colorimetric assay and circular dichroism (CD. Type, i.e., either 2-Hydroxy-1-[4-(2-hydroxyethoxy phenyl]-2-methyl-1-propanone (I2959 or lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP, and concentration of photoinitiator were varied to ensure minimal photoinitiator-induced cytotoxicity and to enable thiol-ene network formation of collagen-PEG mixtures. The viability of G292 cells following 24 h culture in photoinitiator-supplemented media was largely affected by the photoinitiator concentration, with I2959-supplemented media observed to induce higher toxic response (0.1 → 0.5% (w/v I2959, cell survival: 62 → 2 Abs.% compared to LAP-supplemented media (cell survival: 86 → 8 Abs.%. In line with the in vitro study, selected photoinitiator concentrations were used to prepare thiol-ene photo-click hydrogels. Gelation kinetics proved to be largely affected by the specific photoinitiator, with LAP-containing thiol-ene mixtures leading to significantly reduced complete gelation time (τ: 187 s with respect to I2959-containing mixtures (τ: 1683 s. Other than the specific photoinitiator, the photoinitiator concentration was key to adjusting the hydrogel storage modulus (G’, whereby 15-fold G’ increase (232 → 3360 Pa was observed in samples prepared with 0.5% (w/v compared to 0.1% (w/v LAP. Further thiol-ene formulations with 0.5% (w/v LAP and varied content of PEG-NB were tested to prepare photo-click hydrogels with porous architecture, as well as tunable storage modulus (G

  12. Koolirõõmuta kool on lapsele kui sunnitöö / Ene-Silvia Sarv ; intervjueerinud Karin Klaus

    Index Scriptorium Estoniae

    Sarv, Ene-Silvia, 1945-

    2013-01-01

    Intervjuu Pärnus hariduskonverentsil "Õnnelik õpilane, õnnelik õpetaja" esinenud Tallinna ülikooli lektori Ene-Silvia Sarvega, kes rääkis oma ettekandes, milline paistab tänapäeva kool õpilaste silme läbi ja mis mõjutab koolikliimat kõige enam

  13. Rapid and simple preparation of thiol–ene emulsion-templated monoliths and their application as enzymatic microreactors

    Czech Academy of Sciences Publication Activity Database

    Lafleur, J. P.; Senkbeil, S.; Novotný, Jakub; Nys, G.; Bøgelund, N.; Rand, K. D.; Foret, František; Kutter, J. P.

    2015-01-01

    Roč. 15, č. 10 (2015), s. 2162-2172 ISSN 1473-0197 R&D Projects: GA ČR(CZ) GBP206/12/G014 Institutional support: RVO:68081715 Keywords : thiol-enes * mictoreactor * monolith * fabrication * proteins Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 5.586, year: 2015

  14. Kas erivajadustega lapsed saavad õigel ajal abi? / Ene Mägi, Urve Raudsepp-Alt, Ale Sprenk, Peeter Aas

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad: Tallinna Ülikooli Kasvatusteaduste Instituudi eri- ja sotsiaalpedagoogika osakonna juhataja Ene Mägi, Tallinna Haridusameti üldhariduse osakonna peaspetsialist Urve Raudsepp-Alt, Krabi põhikooli direktor Ale Sprenk, Põlva Maavalitsuse haridus-, kultuuri- ja sotsiaalosakonna juhataja Peeter Aas

  15. Poly(ethylene glycol)-based thiol-ene hydrogel coatings: curing chemistry, aqueous stability, and potential marine antifouling applications

    NARCIS (Netherlands)

    Lundberg, P.; Bruin, A.; Klijnstra, J.W.; Nyström, A.M.; Johansson, M.; Malkoch, M.; Hult, A.

    2010-01-01

    Photocured thiol-ene hydrogel coatings based on poly(ethylene glycol) (PEG) were investigated for marine antifouling purposes. By varying the PEG length, vinylic end-group, and thiol cross-linker, a library of hydrogel coatings with different structural composition was efficiently accomplished, with

  16. Limitations of the Neurological Evolutional Exam (ENE as a motor assessment for first graders Limitações do Exame Neurológico Evolutivo (ENE como um instrumento de avaliação motora para crianças da primeira série

    Directory of Open Access Journals (Sweden)

    Priscila M. Caçola

    2010-10-01

    Full Text Available BACKGROUND: Many clinicians and researchers in Brazil consider the Neurological Developmental Exam (NDE, a valid and reliable assessment for Brazilian school-aged children. However, since its inception, several tests have emerged that, according to some researchers, provide more in-depth evaluation of motor ability and go beyond the detection of general motor status (soft neurological signs. OBJECTIVES: To highlight the limitations of the NDE as a motor skill assessment for first graders. METHODS: Thirty-five children were compared on seven selected items of the NDE, seven of the Bruininks-Oseretsky Test (BOT, and seven of the Visual-Motor Integration test (VMI. Participants received a "pass" or "fail" score for each item, as prescribed by the respective test manual. RESULTS: Chi-square and ANOVA results indicated that the vast majority of children (74% passed the NDE items, whereas values for the other tests were 29% (BOT and 20% (VMI. Analysis of specific categories (e.g. visual, fine, and gross motor coordination revealed a similar outcome. CONCLUSIONS: Our data suggest that while the NDE may be a valid and reliable test for the detection of general motor status, its use as a diagnostic/remedial tool for identifying motor ability is questionable. One of our recommendations is the consideration of a revised NDE in light of the current needs of clinicians and researchers.CONTEXTUALIZAÇÃO: Muitos clínicos e pesquisadores brasileiros consideram o Exame Neurológico Evolutivo (ENE, um instrumento válido e confiável para crianças brasileiras em idade escolar. Entretanto, desde a sua criação, surgiram outros testes para uma avaliação mais profunda de habilidade motora, os quais vão além de detectar status motor geral em forma de sinais neurológicos leves. OBJETIVOS: Demonstrar os pontos fracos do ENE como teste de avaliação de habilidade motora para crianças de primeira série. MÉTODOS: Trinta e cinco crianças realizaram 7 itens

  17. A Convergent Enantioselective Total Synthesis of (-)-Perhydrohistrionicotoxin with an Intramolecular Imino Ene-type Reaction as a Key Step

    DEFF Research Database (Denmark)

    Tanner, David Ackland; Hagberg, Lars

    1998-01-01

    A convergent enantioselective total synthesis of the neurotoxic spirocyclic alkaloid (-)-perhydrohistrionicotoxin (2) is described. A Lewis acid-mediated intramolecular imine ene-type reaction was used for the key spirocyclisation step (14 to 3, with 3 being obtained as a single diastereoisomer...

  18. Listen; There's a Hell of a Good Universe Next Door; Let's Go

    Science.gov (United States)

    Rigby, Jane R.

    2012-01-01

    Scientific research is key to our nation's technological and economic development. One can attempt to focus research toward specific applications, but science has a way of surprising us. Think for example of the "charge-couple device", which was originally invented for memory storage, but became the modern digital camera that is used everywhere from camera phones to the Hubble Space Telescope. Using digital cameras, Hubble has taken pictures that reach back 12 billion light-years into the past, when the Universe was only 1-2 billion years old. Such results would never have been possible with the film cameras Hubble was originally supposed to use. Over the past two decades, Hubble and other telescopes have shown us much about the Universe -- many of these results are shocking. Our galaxy is swarming with planets; most of the mass in the Universe is invisible; and our Universe is accelerating ever faster and faster for unknown reasons. Thus, we live in a "hell of a good universe", to quote e.e. cummings, that we fundamentally don't understand. This means that you, as young scientists, have many worlds to discover

  19. Draama 2007. Töörahu / Ene Paaver

    Index Scriptorium Estoniae

    Paaver, Ene, 1963-

    2008-01-01

    Ülevaade 2007. aasta eesti draamast. Pikemalt käsitletakse järgmisi autoreid ja nende näidendeid: Mart Kivastik "Tõnu võitlused", Mart Kivastik "Eesti asi", Mart Kivastik "Sõdur", Mart Kivastik "Kuninga viimane lahing ja ülikooli algus", Mart Kivastik, "Nokia 3310", Andrus Kivirähk "Voldemar", Andrus Kivirähk "Uljas neitsi", Hendrik Toompere "Kommunisti surm", Andres Ehin "Saatuslik kihlvedu ehk Volquin Varbola all", Jan Rahman "Jõujaam", Jaak Kõdar "Muinassaar", Karl Berg "Teekond valguse riiki", Angela Randmets "Lembelood vanas linnas", Toomas Kall "Tähtede sadu", Lauri Vahtre "Muna EÜE", Urmas Espenberg "Kestvad kiiduavaldused", Kalju Saaber "Koduvõõrad", Indrek Hirv "Pauluse kiriku kellad", Katrin Saukas "Võlg", Heidi Sarapuu "Austatud Riigikogu liikmed!", Heidi Sarapuu "Helisev viis", Heidi Sarapuu "Ankur hiivata", Jakob Karu "Vanaema juures", Jim Ashilevi "Nagu poisid vihma käes", Jim Ashilevi "Portselansuits", Eva Koff "Mirr", Jaak Prints "Karaoke", Kati Murutar "Mina, naine!", Ott Aardam "Börs ja Börsitar", Andrus Kivirähk, Jan Rahman, Contra "Kõrts", Mart Kase "Perekond", Villu Tamme "Haned võlgu"; Tiit Ojasoo ja Ene-Liis Semperi "GEP ehk Gorjatshije estonskije parni"

  20. Investigation of curing rates of bio-based thiol-ene films from diallyl 2,5-furandicaboxylate

    DEFF Research Database (Denmark)

    Larsen, Daniel Bo; Sønderbæk-Jørgensen, Rene; Duus, Jens Ø.

    2018-01-01

    The bio-based monomer, 2,5-furandicarboxylic acid, has been adapted to classic thiol-ene chemistry by derivatization of the acid with allyl alcohol. This new monomer has allowed for the synthesis of new thermoset systems, capable of forming green, sustainable materials through UV-crosslinking. In......The bio-based monomer, 2,5-furandicarboxylic acid, has been adapted to classic thiol-ene chemistry by derivatization of the acid with allyl alcohol. This new monomer has allowed for the synthesis of new thermoset systems, capable of forming green, sustainable materials through UV......-crosslinking. In this study, the synthesis of the new monomer along with thorough kinetic studies of the new thermoset systems are presented. In order to determine kinetic values for the systems, all reactions have been followed by real-time FT-IR. Initially, a study of three different photoinitiators is performed...... on a classic TEMPIC-TATATO system, in order to determine the superior initiator for the new systems. The new monomer is crosslinked with five different thiol compounds in both stoichiometric and off-stoichiometric ratios, yielding an array of bio-based thermosets. The properties of these systems are determined...

  1. Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes

    Energy Technology Data Exchange (ETDEWEB)

    Surendradoss, Jayakumar; Chang, Thomas K.H.; Abbott, Frank S., E-mail: frank.abbott@ubc.ca

    2012-11-01

    Valproic acid (VPA) undergoes cytochrome P450-mediated desaturation to form 4-ene-VPA, which subsequently yields (E)-2,4-diene-VPA by β-oxidation. Another biotransformation pathway involves β-oxidation of VPA to form (E)-2-ene-VPA, which also generates (E)-2,4-diene-VPA by cytochrome P450-mediated desaturation. Although the synthetic form of (E)-2,4-diene-VPA is more hepatotoxic than VPA as shown in various experimental models, there is no conclusive evidence to implicate the in situ generated (E)-2,4-diene-VPA in VPA hepatotoxicity. The present study investigated the effects of modulating the in situ formation of (E)-2,4-diene-VPA on markers of oxidative stress (formation of 2′,7′-dichlorofluorescein; DCF), steatosis (accumulation of BODIPY 558/568 C{sub 12}), necrosis (release of lactate dehydrogenase; LDH), and on cellular total glutathione (GSH) levels in sandwich-cultured rat hepatocytes treated with VPA or (E)-2-ene-VPA. Treatment with either of these chemicals alone increased each of the toxicity endpoints. In VPA-treated hepatocytes, (E)-2,4-diene-VPA was detected only at trace levels, even after phenobarbital (PB) pretreatment and there was no effect on the toxicity of VPA. Furthermore, pretreatment with a cytochrome P450 enzyme inhibitor, 1-aminobenzotriazole (1-ABT), did not influence the extent of VPA toxicity in both PB-pretreated and vehicle-pretreated hepatocytes. However, in (E)-2-ene-VPA-treated hepatocytes, PB pretreatment greatly enhanced the levels of (E)-2,4-diene-VPA and this was accompanied by a further enhancement of the effects of (E)-2-ene-VPA on DCF formation, BODIPY accumulation, LDH release, and GSH depletion. Pretreatment with 1-ABT reduced the concentrations of (E)-2,4-diene-VPA and the extent of (E)-2-ene-VPA toxicity; however, this occurred in PB-pretreated hepatocytes, but not in control hepatocytes. In conclusion, in situ generated (E)-2,4-diene-VPA is not responsible for the hepatocyte toxicity of VPA, whereas it

  2. Ene-Liis Semper: selle aasta puhkepäevad võib ühe käe sõrmedel kokku lugeda

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2011-01-01

    Tallinna kultuuripealinna projekti panustanud Ene-Liis Semper võtab 2011. aasta sündmused kokku ja selgitab, kuidas jõudsid publiku ette suurlavastused "The Rise and Fall of Estonia", "Three Kingdoms", Põhuteater ning isikunäitus Kumus

  3. Hydrophobic thiol-ene surfaces fabricated via plasma activation and photo polymerization

    Science.gov (United States)

    Champathet, P.; Ervithayasuporn, V.; Osotchan, T.; Dangtip, S.

    2017-09-01

    Alumina, such as glazed alumina for electrical insulator, operated in an open field subjects to a very harsh condition; resulting in lifetime shortening. Coating hydrophobic layer on alumina surface can help prolonging its lifetime. In this study, 25 ×25 mm alumina sheets were used as substrates. The hydrophobic composite polymers were prepared from (3-mercaptopropyl)trimethoxysilane(MPTMS), 2,4,6,8-tetramethyl-2,4,6,8tetravinylcyclotetra siloxane(TMTVSi), pentaerythritoltetra(3-mercaptopropionate)(PETMP), 2,2-dimethoxy-2-phe nylaceto phenone(photoinitiator) and heptadecafluorodecylmethacrylate(HEFDMA) via the thiol-ene reaction. The alumina sheets were first activated by dielectric-barrier discharge plasma to improve its adhesion. All the polymers were found to optimize at the ratio of (MPTMS:TMTVSi:PETMP:HDFDMA) to 4:2:1:2 for coating on the alumina substrate. To enhance polymerization, 2,2-dimethoxy-2-phenylaceto phenome was also used as a photoinitiator A proper mixing sequence in the thiol-ene reaction results in film with excellent surface retention after prolong soaking in solvent such as acetone. FTIR shows that S-H and C=C functional groups have significantly changed after photopolymerization and thermally cured. The static contact angle increase from mere 53.0°±1.5° of the uncoated substrate to 120.0°±1.2° after coating. SEM shows the film with clear appearance of a few-micron thick. Under AFM, the coated surface roughness was about 9.3 nm with evenly distributed spikes of a few nanometer in height. The cross-cut test also confirmed the film was very smooth and none of the square of the films detached.

  4. Mida teie oma tervise heaks teete? / Ly Jagor, Ülle Mihhailova, Ene Pill, Katrin Käbin...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Pärnu Õppenõustamiskeskuse psühholoog Ly Jagor, Maasika lasteaia juhataja asetäitja Ülle Mihhailova, Tallinna Perekeskuse ja Tähetorni lastekeskuse psühholoog Ene Pill, Tallinna Nõmme Noortemaja väikelaste ringijuht Katrin Käbin, Tääksi Põhikooli õpetaja Silva Kolk

  5. Inorganic-Organic Thiol-ene Coated Mesh for Oil/Water Separation.

    Science.gov (United States)

    Chen, Qiyi; de Leon, Al; Advincula, Rigoberto C

    2015-08-26

    A highly efficient mesh for oil/water separation was fabricated by using a superhydrophobic and superoleophilic coating of thiol-ene hybrid, consisting of pentaerythritol tetra(3-mercaptopropionate) (PETMP), 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (TMTVSi), and hydrophobic fumed silica nanoparticles, via a simple two-step fabrication process. Spray deposition and UV curing photopolymerization were sequentially performed, during which solvent evaporation provides microscale roughness while nanoparticle aggregation forms nanoscale roughness. The hierarchical morphologies were stabilized after UV curing photopolymerization. High contact angle (>150°) and low roll-off angle (<5°) were achieved due to the multiscale roughness structure of the hierarchical morphologies. These coatings also have excellent chemical resistance, as well as temperature and pH stability, after curing.

  6. Afraid of the Dark and the Light: Visceralizing Ecocide in The Road and Hell

    Directory of Open Access Journals (Sweden)

    Alexa Weik von Mossner

    2012-01-01

    Full Text Available The essay is concerned with the ways in which contemporary science fiction films explore the future subjectivities and societies that may result from radical ecological changes, looking at two pertinent examples from two different national traditions: John Hillcoat’s 2009 film adaptation of Cormac McCarthy’s Pulitzer Prize-winning novel The Road (2006, and one of the very few German-Swiss science fiction films with an environmental theme, Tim Fehlbaum’s Hell (2011. It is particularly interested in the relationship between the films’ imagined ecological spaces and the actions of the protagonists of each film on the one hand, and in the relationship between these futuristic diegetic spaces and the contemporary real-life ecological spaces that “play” them on the other hand. Together with the performances of the human actors and the tension and suspense built by the narratives, it argues, the spectacle and insinuated agency of these ecological spaces are centrally responsible for the films’ emotional force and for their ability to engage viewers in stories of global ecocide and human survival.

  7. Thiol-ene thermosets exploiting surface reactivity for layer-by-layer structures and control of penetration depth for selective surface reactivity

    DEFF Research Database (Denmark)

    Daugaard, Anders Egede; Westh, Andreas; Pereira Rosinha Grundtvig, Ines

    Thiol-ene thermosets have been shown to be an efficient platform for preparation of functional polymer surfaces. Especially the effectiveness and versatility of the system has enabled a large variety of network properties to be obtained in a simple and straight-forward way. Due to its selectivity......, various thiols and allyl or other vinyl reactants can be used to obtain either soft and flexible1 or more rigid functional thermosets 2. The methodology permits use of etiher thermal or photochemical conditions both for matrix preparation as well as for surface functionalization. Due to excess reactive...... groups in thµe surface of thiol-ene thermosets, it is possible to prepare surface functional thermosets or to exploit the reactive groups for modular construction and subsequent chemical bonding. Here a different approach preparing monolithic layer-by-layer structures with controlled mechanical...

  8. Ära söö kiles saia ehk kas poliitilist kunsti on võimalik mõista? = Do not eat white bread in plastic, or is it possible to understand political art? / Ene-Liis Semper, Eero Epner

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2006-01-01

    Poliitillisest teatrist. NO99 lavastusest "Nafta" (lavastajad, autorid: Tiit Ojasoo, Ene-Liis Semper, kunstnik Ene-Liis Semper). Ettekanne Kaasaegse Kunsti Eesti Keskuse 4. ettekannete päeval "Kunstnike moraalsed valikud kultuurikonfliktides" Tallinna Kunstihoones 27.04.2006. Bibliograafia lk. 112

  9. Experience with two large-scale Hell-cryostats for a superconducting RF particle separator working in closed cycle with a 300 W refrigerator

    CERN Document Server

    Barth, W

    1976-01-01

    The contribution of the Karlsruhe Institut fur Experimental Kernphysik to the RF particle separator at the SPS/CERN consists of the two superconducting deflectors and their Hell-cryostats with the cryogenic and vacuum accessories. The cryostats have to fulfil specifications concerning tightness, thermal insulation, adjustment of the cavities to the beam and reliability. Corresponding cryogenic and RF tests are performed in Karlsruhe before a 300 W refrigerator simulating normal and emergency conditions. Following a description of cryostats design the results of these measurements are compared with the specifications. Operating experience with the cryostats in closed circuit with the refrigerator are reported. (5 refs).

  10. 3-(2-Benzofuranyl)quinuclidin-2-ene derivatives: novel muscarinic antagonists.

    Science.gov (United States)

    Nordvall, G; Sundquist, S; Johansson, G; Glas, G; Nilvebrant, L; Hacksell, U

    1996-08-16

    A series of 26 derivatives of the novel muscarinic antagonist 3-(2-benzofuranyl)quinuclidin-2-ene (1) has been synthesized and evaluated for muscarinic and antimuscarinic properties. The affinity of the compounds was determined by competition experiments in homogenates of cerebral cortex, heart, parotid gland, and urinary bladder from guinea pigs using (-)-[3H]-3-quinuclidinyl benzilate as the radioligand, and the antimuscarinic-potency was determined in a functional assay on isolated guinea pig urinary bladder using carbachol as the agonist. The 5-fluorobenzofuranyl derivative was slightly more potent than 1. The 7-bromo-substituted 8 displayed a 14-fold tissue selectivity ratio for muscarinic receptors in the cortex versus the parotid gland. Comparative molecular field analysis and quantitative structure-activity relationship models were developed for this series of substituted benzofuranyl derivatives.

  11. Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme.

    Science.gov (United States)

    Adalbjörnsson, Björn V; Toogood, Helen S; Fryszkowska, Anna; Pudney, Christopher R; Jowitt, Thomas A; Leys, David; Scrutton, Nigel S

    2010-01-25

    We report the crystal structure of a thermophilic "ene" reductase (TOYE) isolated from Thermoanaerobacter pseudethanolicus E39. The crystal structure reveals a tetrameric enzyme and an active site that is relatively large compared to most other structurally determined and related Old Yellow Enzymes. The enzyme adopts higher order oligomeric states (octamers and dodecamers) in solution, as revealed by sedimentation velocity and multiangle laser light scattering. Bead modelling indicates that the solution structure is consistent with the basic tetrameric structure observed in crystallographic studies and electron microscopy. TOYE is stable at high temperatures (T(m)>70 degrees C) and shows increased resistance to denaturation in water-miscible organic solvents compared to the mesophilic Old Yellow Enzyme family member, pentaerythritol tetranitrate reductase. TOYE has typical ene-reductase properties of the Old Yellow Enzyme family. There is currently major interest in using Old Yellow Enzyme family members in the preparative biocatalysis of a number of activated alkenes. The increased stability of TOYE in organic solvents is advantageous for biotransformations in which water-miscible organic solvents and biphasic reaction conditions are required to both deliver novel substrates and minimize product racemisation.

  12. Hydrophobic Coatings by Thiol-Ene Click Functionalization of Silsesquioxanes with Tunable Architecture.

    Science.gov (United States)

    Dirè, Sandra; Bottone, Davide; Callone, Emanuela; Maniglio, Devid; Génois, Isabelle; Ribot, François

    2017-08-08

    The hydrolysis-condensation of trialkoxysilanes under strictly controlled conditions allows the production of silsesquioxanes (SSQs) with tunable size and architecture ranging from ladder to cage-like structures. These nano-objects can serve as building blocks for the preparation of hybrid organic/inorganic materials with selected properties. The SSQs growth can be tuned by simply controlling the reaction duration in the in situ water production route (ISWP), where the kinetics of the esterification reaction between carboxylic acids and alcohols rules out the extent of organosilane hydrolysis-condensation. Tunable SSQs with thiol functionalities (SH-NBBs) are suitable for further modification by exploiting the simple thiol-ene click reaction, thus allowing for modifying the wettability properties of derived coatings. In this paper, coatings were prepared from SH-NBBs with different architecture onto cotton fabrics and paper, and further functionalized with long alkyl chains by means of initiator-free UV-induced thiol-ene coupling with 1-decene (C10) and 1-tetradecene (C14). The coatings appeared to homogeneously cover the natural fibers and imparted a multi-scale roughness that was not affected by the click functionalization step. The two-step functionalization of cotton and paper warrants a stable highly hydrophobic character to the surface of natural materials that, in perspective, suggests a possible application in filtration devices for oil-water separation. Furthermore, the purification of SH-NBBs from ISWP by-products was possible during the coating process, and this step allowed for the fast, initiator-free, click-coupling of purified NBBs with C10 and C14 in solution with a nearly quantitative yield. Therefore, this approach is an alternative route to get sol-gel-derived, ladder-like, and cage-like SSQs functionalized with long alkyl chains.

  13. Fabrication of antibody-loaded microgels using microfluidics and thiol-ene photoclick chemistry.

    Science.gov (United States)

    Gregoritza, Manuel; Abstiens, Kathrin; Graf, Moritz; Goepferich, Achim M

    2018-06-01

    Reducing burst effects, providing controlled release, and safeguarding biologics against degradation are a few of several highly attractive applications for microgels in the field of controlled release. However, the incorporation of proteins into microgels without impairing stability is highly challenging. In this proof of concept study, the combination of microfluidics and thiol-ene photoclick chemistry was evaluated for the fabrication of antibody-loaded microgels with narrow size distribution. Norbornene-modified eight-armed poly(ethylene glycol) with an average molecular mass of 10,000 Da, 20,000 Da, or 40,000 Da were prepared as macromonomers for microgel formation. For functionalization, either hydrolytically cleavable ester or stable amide bonds were used. A microfluidic system was employed to generate precursor solution droplets containing macromonomers, the cross-linker dithiothreitol and the initiator Eosin-Y. Irradiation with visible light was used to trigger thiol-ene reactions which covalently cross-linked the droplets. For all bond-types, molecular masses, and concentrations gelation was very rapid (<20 s) and a plateau for the complex shear modulus was reached after only 5 min. The generated microgels had a rod-like shape and did not show considerable cellular toxicity. Stress conditions during the fabrication process were simulated and it could be shown that fabrication did not impair the activity of the model proteins lysozyme and bevacizumab. It was confirmed that the average hydrogel network mesh size was similar or smaller than the hydrodynamic diameter of bevacizumab which is a crucial factor for restricting diffusion and delaying release. Finally, microgels were loaded with bevacizumab and a sustained release over a period of 30 ± 4 and 47 ± 7 days could be achieved in vitro. Copyright © 2018 Elsevier B.V. All rights reserved.

  14. Katkenud õpingute teise kõrgkooli "kolimine" nõuab visadust / Agne Narusk, Ene Küüner, Heli Mattisen, Kadri Osula

    Index Scriptorium Estoniae

    Narusk, Agne

    2007-01-01

    Pooleli jäänud ülikooliõpingute lõpetamisest. Varasemate õpingute ja töökogemuse arvestamise tingimusi õpingute jätkamisel selgitavad Tartu Ülikooli avatud ülikooli tasemeõppe koordinaator Ene Küüner, Tallinna Ülikooli akadeemiline prorektor Heli Mattisen ja Estonian Business Schoolì õppeosakonna juhataja Kadri Osula

  15. A neutral polyacrylate copolymer coating for surface modification of thiol-ene microchannels for improved performance of protein separation by microchip electrophoresis

    DEFF Research Database (Denmark)

    Mesbah, Kiarach; Mai, T.D.; Jensen, Thomas Glasdam

    2016-01-01

    We have investigated the behavior of thiol-ene substrates that is a class of promising materials for lab-on-a-chip electrophoresis applications. Two polymeric materials were prepared by copolymerization of N, N-dimethylacrylamide (DMA), (3-(methacryloyl-oxy)propyl)trimethoxysilane (PMA) and 3-tri...

  16. Selective fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene by nucleotides.

    Science.gov (United States)

    Marquez, Cesar; Pischel, Uwe; Nau, Werner M

    2003-10-16

    [reaction: see text] The fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by nucleotides has been studied. The quenching mechanism was analyzed on the basis of deuterium isotope effects, tendencies for exciplex formation, and the quenching efficiency in the presence of a molecular container (cucurbit[7]uril). Exciplex-induced quenching appears to prevail for adenosine, cytidine, and uridine, while hydrogen abstraction becomes competitive for thymidine and guanosine. Compared to other fluorescent probes, DBO responds very selectively to the type of nucleotide.

  17. Thiol-ene click chemistry derived cationic cyclodextrin chiral stationary phase and its enhanced separation performance in liquid chromatography.

    Science.gov (United States)

    Yao, Xiaobin; Tan, Timothy Thatt Yang; Wang, Yong

    2014-01-24

    This work is the first demonstration of a simple thiol-ene click chemistry to anchor vinyl imidazolium β-CD onto thiol silica to form a novel cationic native cyclodextrin (CD) chiral stationary phase (CSP). The CSP afforded high enantioseparation ability towards dansyl (Dns) amino acids, carboxylic aryl compounds and flavonoids in chiral HPLC. The current CSP demonstrates the highest resolving ability (selectivity >1.1, resolution >1.5) towards Dns amino acids in a mobile phase buffered at pH=6.5, with the resolution of Dns-dl-leucine as high as 6.97. 2,4-dichloride propionic acid (2,4-ClPOPA) was well resolved with the selectivity and resolution of 1.37 and 4.88, respectively. Compared to a previously reported native CD-CSP based on a triazole linkage, the current cationic CD-CSP shows a stronger retention and higher resolution towards acidic chiral compounds, ascribed to the propitious strong electrostatic attraction. Stability evaluation results indicated that thiol-ene reaction can provide a facile and robust approach for the preparation of positively charged CD CSPs. Copyright © 2013 Elsevier B.V. All rights reserved.

  18. Functional characterization and stability improvement of a ‘thermophilic-like’ ene-reductase from Rhodococcus opacus 1CP

    Directory of Open Access Journals (Sweden)

    Anika eRiedel

    2015-10-01

    Full Text Available Ene-reductases are widely applied for the asymmetric synthesis of relevant industrial chemicals. A novel ene-reductase OYERo2 was found within a set of 14 putative Old Yellow Enzymes (OYEs obtained by genome mining of the actinobacterium Rhodococcus opacus 1CP. Multiple sequence alignment suggested that the enzyme belongs to the group of ‘thermophilic-like’ OYEs. OYERo2 was produced in Escherichia coli and biochemically characterized. The enzyme is strongly NADPH dependent and uses non-covalently bound FMNH2 for the reduction of activated α,β-unsaturated alkenes. In the active form OYERo2 is a dimer. Optimal catalysis occurs at pH 7.3 and 37 °C. OYERo2 showed highest specific activities (4550 U mg-1 on maleimides, which are efficiently converted to the corresponding succinimides. The OYERo2-mediated reduction of prochiral alkenes afforded the (R-products with excellent optical purity (ee > 99%. OYERo2 is not as thermo-resistant as related OYEs. Introduction of a characteristic intermolecular salt bridge by site-specific mutagenesis raised the half-life of enzyme inactivation at 32 °C from 28 min to 87 min and improved the tolerance towards organic co-solvents. The suitability of OYERo2 for application in industrial biocatalysis is discussed.

  19. Polysiloxane-based luminescent elastomers prepared by thiol-ene "click" chemistry.

    Science.gov (United States)

    Zuo, Yujing; Lu, Haifeng; Xue, Lei; Wang, Xianming; Wu, Lianfeng; Feng, Shengyu

    2014-09-26

    Side-chain vinyl poly(dimethylsiloxane) has been modified with mercaptopropionic acid, methyl 3-mercaptopropionate, and mercaptosuccinic acid. Coordinative bonding of Eu(III) to the functionalized polysiloxanes was then carried out and crosslinked silicone elastomers were prepared by thiol-ene curing reactions of these composites. All these europium complexes could be cast to form transparent, uniform, thin elastomers with good flexibility and thermal stability. The networks were characterized by FTIR, NMR, UV/Vis, and luminescence spectroscopy as well as by scanning electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy. The europium elastomer luminophores exhibited intense red light at 617 nm under UV excitation at room temperature due to the (5)D0 →(7)F2 transition in Eu(III) ions. The newly synthesized luminescent materials offer many advantages, including the desired mechanical flexibility. They cannot be dissolved or fused, and so they have potential for use in optical and electronic applications. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Synthesis of Upconverting Hydrogel Nanocomposites Using Thiol-Ene Click Chemistry: Template for the Formation of Dendrimer-Like Gold Nanoparticle Assemblies.

    Science.gov (United States)

    Meesaragandla, Brahmaiah; Mahalingam, Venkataramanan

    2015-11-16

    The synthesis of upconverting hydrogel nanocomposites by base-catalyzed thiol-ene click reaction between 10-undecenoic acid capped Yb(3+)/Er(3+)-doped NaYF4 nanoparticles and pentaerythritol tetrakis(3-mercaptopropionate) (PETMP) as tetrathiol monomer is reported. This synthetic strategy for nanocomposite gels is quite different from works where usually the preformed gels are mixed with the nanoparticles. Developing nanocomposites by surface modification of capping ligands would allow tuning and controlling of the separation of the nanoparticles inside the gel network. The hydrogel nanocomposites prepared by thiol-ene click reaction show strong enhancement in luminescence intensity compared to 10-undecenoic acid-capped Yb(3+)/Er(3+)-doped NaYF4 nanoparticles through the upconversion process (under 980 nm laser excitation). The hydrogel nanocomposites display strong swelling characteristics in water resulting in porous structures. Interestingly, the resulting nanocomposite gels act as templates for the synthesis of dendrimer-like Au nanostructures when HAuCl4 is reduced in the presence of the nanocomposite gels. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Kui oluliseks isikuandmete kaitsmist kooli oludes peate ja millest seda tehes lähtute? / Harri Kõo, Ene Tannberg, Kalle Niinas, Maria Tiro...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Tabasalu Ühisgümnaasiumi direktor Harri Kõo, Tartu Miina Härma Gümnaasiumi direktor Ene Tannberg, Jakob Westholmi Gümnaasiumi direktor Kalle Niinas, Jüri Gümnaasiumi direktor Maria Tiro ja Viimsi Keskkooli direktor Leelo Tiisvelt

  2. Restauración paisajística de Cantera Rosales. Hellín (Albacete, España

    Directory of Open Access Journals (Sweden)

    Daniel Moreno Ruiz

    2016-07-01

    Full Text Available El texto describe y dibuja una estrategia de recuperación ecológica de una explotación minera de piedra ornamental en activo, situada en el entorno del parque arqueológico del Tolmo de Minateda, en el Término municipal de Hellín (Albacete, España. En el año 2015, la empresa Areniscas Rosal, propietaria de los derechos de explotación de dicha cantera, encargó a la oficina de Arquitectura y Urbanismo SSS (Spanish Studio of Space un Plan de Restauración para establecer las directrices básicas de una recuperación paisajística que revierta el impacto de la actividad extractiva en un futuro próximo. El proyecto, fundamentado en la filosofía del Land Art, es una reconstrucción geométrica del terreno por medio de la reutilización de los sobrantes de la propia actividad, para así crear un paisaje totalmente nuevo y contemporáneo. El reciclaje, la re-vegetación y una solución proyectual innovadora fundamentan las directrices de esta intervención paisajística y territorial. Las posibilidades de reutilización y disfrute de este nuevo entorno natural podrán ser variadas y enriquecedoras y solo dependerán de una gestión sensible y respetuosa de la relación del hombre con la naturaleza. The former document describes and draws a strategy of ecological recovery of an ornamental stone mine in active, located in the archaeological park environment of Tolmo de Minateda in the municipality of Hellín (Albacete, Spain. Back in 2015, the company Rosal Sandstones, which owns the rights to exploit the quarry, commissioned the Office of Architecture and Urbanism SSS (Spanish Studio of Space a Restoration Plan in order to establish the basic guidelines for a landscape recovery to revert the impact of mining activity in the near future. The project, based on the philosophy of Land Art, is a geometric reconstruction of the ground by means of reusing the leftovers of the activity itself, to thereby create a totally new and contemporary landscape

  3. Mineralized soft-tissue structure and chemistry in a mummified hadrosaur from the Hell Creek Formation, North Dakota (USA).

    Science.gov (United States)

    Manning, Phillip L; Morris, Peter M; McMahon, Adam; Jones, Emrys; Gize, Andy; Macquaker, Joe H S; Wolff, George; Thompson, Anu; Marshall, Jim; Taylor, Kevin G; Lyson, Tyler; Gaskell, Simon; Reamtong, Onrapak; Sellers, William I; van Dongen, Bart E; Buckley, Mike; Wogelius, Roy A

    2009-10-07

    An extremely well-preserved dinosaur (Cf. Edmontosaurus sp.) found in the Hell Creek Formation (Upper Cretaceous, North Dakota) retains soft-tissue replacement structures and associated organic compounds. Mineral cements precipitated in the skin apparently follow original cell boundaries, partially preserving epidermis microstructure. Infrared and electron microprobe images of ossified tendon clearly show preserved mineral zonation, with silica and trapped carbon dioxide forming thin linings on Haversian canals within apatite. Furthermore, Fourier transform infrared spectroscopy (FTIR) of materials recovered from the skin and terminal ungual phalanx suggests the presence of compounds containing amide groups. Amino acid composition analyses of the mineralized skin envelope clearly differ from the surrounding matrix; however, intact proteins could not be obtained using protein mass spectrometry. The presence of endogenously derived organics from the skin was further demonstrated by pyrolysis gas chromatography mass spectrometry (Py-GCMS), indicating survival and presence of macromolecules that were in part aliphatic (see the electronic supplementary material).

  4. (E-2-((4R,5R-5-((Benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-ylbut-2-ene-1,4-diol

    Directory of Open Access Journals (Sweden)

    Carlos R. Carreras

    2010-04-01

    Full Text Available The synthesis of (E-2-((4R,5R-5-((benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-ylbut-2-ene-1,4-diol by a one-step reduction of the appropriate 2-substituted butenolide is reported. Product characterization was carried out by IR, 1H NMR, 13C NMR, MS, elemental analysis and optical rotation.

  5. Novel Anti-Biofouling Soft Contact Lens: l-Cysteine Conjugated Amphiphilic Conetworks via RAFT and Thiol-Ene Click Chemistry.

    Science.gov (United States)

    Zhang, Chengfeng; Liu, Ziyuan; Wang, Haiye; Feng, Xiaofeng; He, Chunju

    2017-07-01

    A unique l-cysteine conjugated antifouling amphiphilic conetwork (APCN) is synthesized through end-crosslinking of well-defined triblock copolymers poly(allyl methacrylate)-b-poly(ethylene glycol)-b-poly(allyl methacrylate) via a combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and thiol-ene "click" chemistry. The synthesized poly(ethylene glycol) macro-RAFT agent initiates the polymerization of allyl methacrylate in a controlled manner. The vinyl pendant groups of the precursor partially conjugate with l-cysteine and the rest fully crosslink with mercaptopropyl-containing siloxane via thiol-ene click chemistry under UV irradiation into APCNs, which show distinguished properties, that is, excellent biocompatibility, more than 39.6% water content, 101 barrers oxygen permeability, optimized mechanical properties, and more than 93% visible light transmittance. What's more, the resultant APCNs exhibit eminent resistance to protein adsorption, where the bovine serum albumin and lysozyme adsorption are decreased to 12 and 21 µg cm -2 , respectively. The outstanding properties of APCNs depend on the RAFT controlled method, which precisely designs the hydrophilic/hydrophobic segments and eventually greatly improves the crosslinking efficiency and homogeneity. Meantime, the l-cysteine monolayer can effectively reduce the surface hydrophobicity and prevent protein adsorption, which exhibits the viability for antifouling surface over and under ophthalmic devices, suggesting a promising soft contact lens. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Applied watercourse research - An analysis of future needs. Report from a seminar at Hell, North Troendelag, November 20-21, 1995; Anvendt vassdragsforskning - en analyse av fremtidige behov. Rapport fra seminar paa Hell, Nord-Troendelag, 20-21 november 1995

    Energy Technology Data Exchange (ETDEWEB)

    Skarboevik, E; Faugli, P E [eds.

    1996-02-01

    The future needs for research on issues related to Norwegian watercourse management were discussed at a seminar at Hell near Trondheim, on November 20-21, 1995. This publication reviews the work done on the seminar. Several topics in hydrology and applied watercourse management were discussed and suggestions were made for future research activities. General factors believed to influence future research activities include the possible shift in hydrologic and water science perspective from a segmented to a more holistic view of the watercourse: the expected increasing need for interdisciplinary research and institutional cooperation, the continued need for in-depth understanding of certain disciplines, the significance of an upcoming law on watercourse issues, and the effect of climate change. It is recommended that future research should be concentrated to a few watercourses and that a research programme on watercourse environment should be established. Projects are recommended on floods and flood control, on climate change and its effect on watercourses, on knowledge distribution, on the effects of new strategies such as peaking for management of hydroelectric power plants. These recommendations will be used to develop a research programme for the period 1997-2000. 35 refs., 16 figs., 6 tabs.

  7. Joint statement of the President, Speaker of the Riigikogu and Prime Minister of the Republic of Estonia / Toomas Hendrik Ilves, Ene Ergma, Andrus Ansip

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    President Toomas Hendrik Ilvese, Riigikogu spiikri Ene Ergma ja peaminister Andrus Ansipi ühisavaldus Teise maailmasõja lõpu 62. aastapäeva puhul 8. mail 2007, milles kinnitatakse, et hoolimata Teise maailmasõja ajaloolistest tõlgendustest on kõik Eestis elavad inimesed vabad ning jagavad ühist tulevikku

  8. Facile preparation of organic-silica hybrid monolith for capillary hydrophilic liquid chromatography based on "thiol-ene" click chemistry.

    Science.gov (United States)

    Chen, Ming-Luan; Zhang, Jun; Zhang, Zheng; Yuan, Bi-Feng; Yu, Qiong-Wei; Feng, Yu-Qi

    2013-04-05

    In this work, a one-step approach to facile preparation of organic-inorganic hybrid monoliths was successfully developed. After vinyl-end organic monomers and azobisisobutyronitrile (AIBN) were mixed with hydrolyzed tetramethoxysilane (TMOS) and 3-mercaptopropyltrimethoxysilane (MPTMS), the homogeneous mixture was introduced into a fused-silica capillary for simultaneous polycondensation and "thiol-ene" click reaction to form the organic-silica hybrid monoliths. By employing this strategy, two types of organic-silica hybrid monoliths with positively charged quaternary ammonium and amide groups were prepared, respectively. The functional groups were successfully introduced onto the monoliths during the sol-gel process with "thiol-ene" click reaction, which was demonstrated by ζ-potential assessment, energy dispersive X-ray spectroscopy (EDX), and Fourier transform infrared (FT-IR) spectroscopy. The porous structure of the prepared monolithic columns was examined by scanning electron microscopy (SEM), nitrogen adsorption-desorption measurement, and mercury intrusion porosimetry. These results indicate the prepared organic-silica hybrid monoliths possess homogeneous column bed, large specific surface area, good mechanical stability, and excellent permeability. The prepared monolithic columns were then applied for anion-exchange/hydrophilic interaction liquid chromatography. Different types of analytes, including benzoic acids, inorganic ions, nucleosides, and nucleotides, were well separated with high column efficiency around 80,000-130,000 plates/m. Taken together, we present a facile and universal strategy to prepare organic-silica hybrid monoliths with a variety of organic monomers using one-step approach. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Crystal and Molecular Structure Studies of Ethyl 4-(4-Hydroxyphenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate and Ethyl 4-(3-Bromophenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate

    Directory of Open Access Journals (Sweden)

    Badiadka Narayana

    2012-08-01

    Full Text Available The crystal and molecular structures of the title compounds, ethyl 4-(4-hydroxyphenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate (I and ethyl 4-(3-bromophenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate (II, are reported and confirmed by single crystal X-ray diffraction data. Compound (I, C26H24O5, crystallizes from a methanol solution in the monoclinic C2/c space group with eight molecules in the unit cell. The unit cell parameters are: a = 25.4114(5 Å, b = 8.47440(10 Å, c = 20.6921(4 Å, β = 108.328(2° and V = 4229.92(13 Å3. Disorder is observed throughout the entire molecule with an occupancy ratio 0.690(2:0.310(2. Compound (II, C26H23O4Br, crystallizes from an ethyl acetate solution in the monoclinic P21/c spacegroup with four molecules in the unit cell. The unit cell parameters are a = 17.8991(9 Å, b = 11.4369(6 Å, c = 10.8507(5 Å, β = 92.428(4° and V = 2219.25(19 Å3. Disorder is observed in the cyclohexenone ring and the carboxylate group with an occupancy ratio 0.830(6:0.170(6. Weak O–H...O (I or C–H...O (II intermolecular interactions are observed which influence crystal packing stability. These chalcone derivative types of molecules are important in their ability to act as activated unsaturated systems in conjugated addition reactions of carbanions in the presence of basic catalysts which exhibit a multitude of biological activities.

  10. Synthesis and Transformations of di-endo-3-Aminobicyclo-[2.2.2]oct-5-ene-2-carboxylic Acid Derivatives

    Directory of Open Access Journals (Sweden)

    Márta Palkó

    2011-09-01

    Full Text Available all-endo-3-amino-5-hydroxybicyclo[2.2.2]octane-2-carboxylic acid (13 and all-endo-5-amino-6-(hydroxymethylbicyclo[2.2.2]octan-2-ol (10 were prepared via dihydro-1,3-oxazine or g-lactone intermediates by the stereoselective functionalization of an N-protected derivative of endo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acid (2. Ring closure of b-amino ester 4 resulted in tricyclic pyrimidinones 15 and 16. The structures, stereochemistry and relative configurations of the synthesized compounds were determined by IR and NMR.

  11. Vabariigi presidendi, riigikogu esimehe ja peaministri ühisavaldus 8. mail 2007 / Toomas Hendrik Ilves, Ene Ergma, Andrus Ansip

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2007-01-01

    President Toomas Hendrik Ilvese, Riigikogu spiikri Ene Ergma ja peaminister Andrus Ansipi avaldus Teise maailmasõja lõpu 62. aastapäeva puhul. Ilmunud ka: Severnoje Poberežje 9. mai 2007, lk. 2; Eesti Elu 11. mai 2007, lk. 2, pealk.: Riigijuhtide ühisavaldus Teise maailmasõja mälestuspäeval, ingl. k. lk. 11, pealk.: Joint statement May 8, 2007; ingl. k. Vaba Eesti Sõna 10. mai 2007, lk. 12, pealk.: Joint statement of the President, Speaker of the Parliament and Prime Minister of the Republic of Estonia

  12. Iron complexes of tetramine ligands catalyse allylic hydroxyamination via a nitroso–ene mechanism

    Directory of Open Access Journals (Sweden)

    David Porter

    2015-12-01

    Full Text Available Iron(II complexes of the tetradentate amines tris(2-pyridylmethylamine (TPA and N,N′-bis(2-pyridylmethyl-N,N′-dimethylethane-1,2-diamine (BPMEN are established catalysts of C–O bond formation, oxidising hydrocarbon substrates via hydroxylation, epoxidation and dihydroxylation pathways. Herein we report the capacity of these catalysts to promote C–N bond formation, via allylic amination of alkenes. The combination of N-Boc-hydroxylamine with either FeTPA (1 mol % or FeBPMEN (10 mol % converts cyclohexene to the allylic hydroxylamine (tert-butyl cyclohex-2-en-1-yl(hydroxycarbamate in moderate yields. Spectroscopic studies and trapping experiments suggest the reaction proceeds via a nitroso–ene mechanism, with involvement of a free N-Boc-nitroso intermediate. Asymmetric induction is not observed using the chiral tetramine ligand (+-(2R,2′R-1,1′-bis(2-pyridylmethyl-2,2′-bipyrrolidine ((R,R′-PDP.

  13. Development of a thiol-ene based screening platform for enzyme immobilization demonstrated using horseradish peroxidase

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Pinelo, Manuel; Woodley, John

    2017-01-01

    Efficient immobilization of enzymes on support surfaces requires an exact match between the surface chemistry and the specific enzyme. A successful match would normally be identified through time consuming screening of conventional resins in multiple experiments testing individual immobilization...... strategies. In this study we present a versatile strategy that largely expands the number of possible surface functionalities for enzyme immobilization in a single, generic platform. The combination of many individual surface chemistries and thus immobilization methods in one modular system permits faster...... functionalization by thiol-ene chemistry (TEC) resulted in the formation of a functional monolayer in each well, whereas, polymer surface grafts were introduced through surface chain transfer free radical polymerization (SCT-FRP). Enzyme immobilization on the modified surfaces was evaluated by using a rhodamine...

  14. Facile synthesis of linear-dendritic cholesteryl-poly(epsilon-caprolactone)-b-(L-lysine)(G2) by thiol-ene and azide-alkyne "click" reactions

    DEFF Research Database (Denmark)

    Javakhishvili, Irakli; Binder, W.H.; Tanner, S.

    2010-01-01

    The construction of a linear-dendritic block copolymer consisting of terminal cholesteryl moiety, poly(epsilon-caprolactone), and a second generation L-lysine dendron has been accomplished by the combination of copper(I) catalyzed azide-alkyne and UV-triggered thiol-ene "click" reactions. Ring-op...... and thiocholesterol. Near to quantitative functionalization of the intermediate and final products has been attained as confirmed by NMR spectroscopy and MALDI-TOF spectrometry....

  15. Photolithographic fabrication of solid–liquid core waveguides by thiol-ene chemistry

    International Nuclear Information System (INIS)

    Sagar, Kaushal; Gopalakrishnan, Nimi; Christiansen, Mads Brøkner; Kristensen, Anders; Ndoni, Sokol

    2011-01-01

    In this work we demonstrate an efficient and cleanroom compatible method for the fabrication of solid–liquid core waveguides based on nanoporous polymers. We have used thiol-ene photo-grafting to tune and pattern the hydrophilicity of an originally hydrophobic nanoporous 1, 2-polybutadiene. The generated refractive index contrast between the patterned water-filled volume and the surrounding empty hydrophobic porous polymer allows for light confinement within the water-filled volume—the solid–liquid core. The presented fabrication process is simple and fast. It allows a high degree of flexibility on the type and grade of surface chemistry imparted to the large nanoporous area depending upon the application. The fabrication does not need demanding chemical reaction conditions. Thus, it can be readily used on a standard silicon lithography bench. The propagation loss values reported in this work are comparable with literature values for state-of-the-art liquid-core waveguide devices. The demonstrated waveguide function added to the nanoporous polymer with a very high internal surface area makes the system interesting for many applications in different areas, such as diagnostics and bio-chemical sensing

  16. IMPLEMENTASI PENGELOLAAN AIR MINUM RUMAH TANGGA (PAM RT DI JAWA BARAT DAN (NUSA TENGGARA TIMUR

    Directory of Open Access Journals (Sweden)

    Athena Anwar

    2016-09-01

    Full Text Available Abstract In order to reduce waterborne diseases, the current government and its partners are developing ahousehold water treatment and safety storage (HWTS. This article is part of a study on Development ofAn Evidence-Based Guidelines for Promotion of HWTS which is conducted in three pilot sites: Bandungcity, Bandung district (West Java and Sikka district (East Nusa Tenggara in 2008. The aim of this studywas to find out how the program was implemented and how is the public opinion about the management(processing and storage of drinking water. Data collection was done by interview through a questionnaire.Data source were health officers and partners (qualitative data and the community (quantitative data.Qualitative data processing was performed by the content and the domain method, while quantitative datawas processed through SPSS software. The results show that the government develop the HWTS alongwith its partner: Aman Tirta (Bandung City, Pelita Indonesia (Bandung District, and Dian Desa (SikkaDistrict. Activity of HWTS was done through several stages, such as preparation/dissemination,implementation, monitoring and evaluation. Every partner will have its own way in carrying out the stagesof activity. Not all health officers of district/city states involved in the implementation of the HWTSprogram. It was only Sikka District Health officer that claimed to have fully engaged in the implementationof HWTS in the region. The results of processing and data analysis showed that more than 80% ofrespondents said the HWTS methods were suitable with drinking water treatment for their region. In termsof increasing the water quality, price of materials/tools, and easyness in the water treatment; respondents'opinions very widely.Keywords: HWTS, drinking water, water treatment Abstrak Dalam upaya menurunkan penyakit yang ditularkan melalui air, saat ini pemerintah dan mitrasedang mengembangkan pengelolaan air minum rumah tangga (PAM RT atau household water

  17. Thermal decomposition of lanthanides (III) and yttrium (III) solid complexes from ethyl ene diamine tetraacetic acid

    International Nuclear Information System (INIS)

    Mercadante, A.

    1991-01-01

    Solid state compounds of lanthanides (III) and yttrium derived from ethyl ene diamine tetraacetic acid were prepared from respective basic carbonates, that were neutralized with EDTA stoichiometry quantities. Complexometry with EDTA, thermogravimetry (TG), differential thermal analysis (DTA) and X-ray diffraction have been used in the study of these compounds. The results of complexometry with EDTA as well as TG and DTA curves bed to the stoichiometry of these compounds the following general formula is obeyed: H[Ln(EDTA]. n H 2 O. X-ray powder patterns of these compounds permitted to establish two isomorphous series. The DTA ant TG curves allowed us to study the dehydration process, the thermal stability and thermal decomposition of these compounds. (C.G.C.)

  18. Modelling lactation curve for milk fat to protein ratio in Iranian buffaloes (Bubalus bubalis) using non-linear mixed models.

    Science.gov (United States)

    Hossein-Zadeh, Navid Ghavi

    2016-08-01

    The aim of this study was to compare seven non-linear mathematical models (Brody, Wood, Dhanoa, Sikka, Nelder, Rook and Dijkstra) to examine their efficiency in describing the lactation curves for milk fat to protein ratio (FPR) in Iranian buffaloes. Data were 43 818 test-day records for FPR from the first three lactations of Iranian buffaloes which were collected on 523 dairy herds in the period from 1996 to 2012 by the Animal Breeding Center of Iran. Each model was fitted to monthly FPR records of buffaloes using the non-linear mixed model procedure (PROC NLMIXED) in SAS and the parameters were estimated. The models were tested for goodness of fit using Akaike's information criterion (AIC), Bayesian information criterion (BIC) and log maximum likelihood (-2 Log L). The Nelder and Sikka mixed models provided the best fit of lactation curve for FPR in the first and second lactations of Iranian buffaloes, respectively. However, Wood, Dhanoa and Sikka mixed models provided the best fit of lactation curve for FPR in the third parity buffaloes. Evaluation of first, second and third lactation features showed that all models, except for Dijkstra model in the third lactation, under-predicted test time at which daily FPR was minimum. On the other hand, minimum FPR was over-predicted by all equations. Evaluation of the different models used in this study indicated that non-linear mixed models were sufficient for fitting test-day FPR records of Iranian buffaloes.

  19. Modifying surface resistivity and liquid moisture management property of keratin fibers through thiol-ene click reactions.

    Science.gov (United States)

    Yu, Dan; Cai, Jackie Y; Church, Jeffrey S; Wang, Lijing

    2014-01-22

    This paper reports on a new method for improving the antistatic and liquid moisture management properties of keratinous materials. The method involves the generation of thiols by controlled reduction of cystine disulfide bonds in keratin with tris(2-carboxyethyl) phosphine hydrochloride and subsequent grafting of hydrophilic groups onto the reduced keratin by reaction with an acrylate sulfonate or acrylamide sulfonate through thiol-ene click chemistry. The modified substrates were characterized with Raman spectroscopy and scanning electron microscopy and evaluated for their performance changes in liquid moisture management, surface resistivity, and wet burst strength. The results have revealed that the thiol-acrylate reaction is more efficient than the thiol-acrylamide reaction, and the keratinous substrate modified with an acrylate sulfonate salt exhibits significantly improved antistatic and liquid moisture management properties.

  20. Applied watercourse research - An analysis of future needs. Report from a seminar at Hell, North Troendelag, November 20-21, 1995

    International Nuclear Information System (INIS)

    Skarboevik, E.; Faugli, P.E.

    1996-02-01

    The future needs for research on issues related to Norwegian watercourse management were discussed at a seminar at Hell near Trondheim, on November 20-21, 1995. This publication reviews the work done on the seminar. Several topics in hydrology and applied watercourse management were discussed and suggestions were made for future research activities. General factors believed to influence future research activities include the possible shift in hydrologic and water science perspective from a segmented to a more holistic view of the watercourse: the expected increasing need for interdisciplinary research and institutional cooperation, the continued need for in-depth understanding of certain disciplines, the significance of an upcoming law on watercourse issues, and the effect of climate change. It is recommended that future research should be concentrated to a few watercourses and that a research programme on watercourse environment should be established. Projects are recommended on floods and flood control, on climate change and its effect on watercourses, on knowledge distribution, on the effects of new strategies such as peaking for management of hydroelectric power plants. These recommendations will be used to develop a research programme for the period 1997-2000. 35 refs., 16 figs., 6 tabs

  1. Summer monsoon onset over Kerala: New definition and prediction

    Indian Academy of Sciences (India)

    hotmail. ... Further, a set of empirical models based on the principal component regression ... J. Earth Syst. Sci. 118 ... tip of India, a maximum cloud zone as identified by. Sikka and ..... indicative of the influence of intraseasonal oscil- lation over ...

  2. Anaesthetic management of endoscopic resection of juvenile ...

    African Journals Online (AJOL)

    P Khanna, BR Ray, R Sinha, R Kumar, K Sikka, AC Singh ... We present the anaesthetic management of endoscopic resection of 14 JNAs, together with a review. ... Mean duration of surgery was 197.14 ± 77 minutes, and median blood loss ...

  3. Indian monsoon variability in relation to Regional Pressure Index

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    From the analysis it has been seen that RPI in the month of May ... made attempts to search the new parameters and .... Sen Roy N and Sikka D R 1991 A power regression model for long ... Thapliyal V 1982 Stochastic dynamic model for long.

  4. Pyriculins A and B, two monosubstituted hex-4-ene-2,3-diols and other phytotoxic metabolites produced by Pyricularia grisea isolated from buffelgrass (Cenchrus ciliaris).

    Science.gov (United States)

    Masi, Marco; Meyer, Susan; Górecki, Marcin; Mandoli, Alessandro; Di Bari, Lorenzo; Pescitelli, Gennaro; Cimmino, Alessio; Cristofaro, Massimo; Clement, Suzette; Evidente, Antonio

    2017-11-01

    Pyricularia grisea has been identified as a foliar pathogen on buffelgrass (Cenchrus ciliaris) in North America and was studied as a potential source of phytotoxins for buffelgrass control. Two monosubstituted hex-4-ene-2,3-diols, named pyriculins A and B, were isolated from its culture filtrate organic extract together with (10S,11S)-(-)-epipyriculol, trans-3,4-dihydro-3,4,8-trihydroxy-1(2H)-napthalenone, and (4S)-(+)-isosclerone. Pyriculins A and B were characterized by spectroscopic (essentially nuclear magnetic resonance [NMR], High-resolution electrospray ionization mass spectrometry [HRESIMS]) and chemical methods such as (4E)-1-(4-hydroxy-1,3-dihydroisobenzofuran-1-yl)hex-4-ene-2,3-diols. The relative and absolute configuration of these compounds was determined by a combination of spectroscopic (NMR, electronic circular dichroism [ECD]) and computational tools. When bioassayed in a buffelgrass coleoptile and radicle elongation test, (10S,11S)-(-)-epipyriculol proved to be the most toxic compound. Seed germination was much reduced and slowed with respect to the control and radicles failed to elongate. All five compounds delayed germination, but only (10S,11S)-(-)-epipyriculol was able to prevent radicle development of buffelgrass seedlings. It had no effect on coleoptile elongation, while the other four compounds caused significantly increased coleoptile development relative to the control. © 2017 Wiley Periodicals, Inc.

  5. The IS-ENES climate4impact portal: bridging the CMIP5 and CORDEX data to impact users

    Science.gov (United States)

    Som de Cerff, Wim; Plieger, Maarten; Page, Christian; Tatarinova, Natalia; Hutjes, Ronald; de Jong, Fokke; Bärring, Lars; Sjökvist, Elin; Vega Saldarriaga, Manuel; Santiago Cofiño Gonzalez, Antonio

    2015-04-01

    The aim of climate4impact (climate4impact.eu) is to enhance the use of Climate Research Data and to enhance the interaction with climate effect/impact communities. The portal is based on 17 impact use cases from 5 different European countries, and is evaluated by a user panel consisting of use case owners. It has been developed within the IS-ENES European project and is currently operated and further developed in the IS ENES2 project. As the climate impact community is very broad, the focus is mainly on the scientific impact community. Climate4impact is connected to the Earth System Grid Federation (ESGF) nodes containing global climate model data (GCM data) from the fifth phase of the Coupled Model Intercomparison Project (CMIP5) and regional climate model data (RCM) data from the Coordinated Regional Climate Downscaling Experiment (CORDEX). This global network of climate model data centers offers services for data description, discovery and download. The climate4impact portal connects to these services using OpenID, and offers a user interface for searching, visualizing and downloading global climate model data and more. A challenging task is to describe the available model data and how it can be used. The portal informs users about possible caveats when using climate model data. All impact use cases are described in the documentation section, using highlighted keywords pointing to detailed information in the glossary. Climate4impact currently has two main objectives. The first one is to work on a web interface which automatically generates a graphical user interface on WPS endpoints. The WPS calculates climate indices and subset data using OpenClimateGIS/icclim on data stored in ESGF data nodes. Data is then transmitted from ESGF nodes over secured OpenDAP and becomes available in a new, per user, secured OpenDAP server. The results can then be visualized again using ADAGUC WMS. Dedicated wizards for processing of climate indices will be developed in close

  6. Crystal structures of three anhydrous salts of the Lewis base 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU with the ring-substituted benzoic acid analogues 4-aminobenzoic acid, 3,5-dinitrobenzoic acid and 3,5-dinitrosalicylic acid

    Directory of Open Access Journals (Sweden)

    Graham Smith

    2016-03-01

    Full Text Available The anhydrous salts of the Lewis base 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU with 4-aminobenzoic acid [1-aza-8-azoniabicyclo[5.4.0]undec-7-ene 4-aminobenzoate, C9H17N2+·C7H6NO2− (I], 3,5-dinitrobenzoic acid [1-aza-8-azoniabicyclo[5.4.0]undec-7-ene 3,5-dinitrobenzoate, C9H17N2+·C7H3N2O6−, (II] and 3,5-dinitrosalicylic acid (DNSA [1-aza-8-azoniabicyclo[5.4.0]undec-7-ene 2-hydroxy-3,5-dinitrobenzoate, C9H17N2+·C7H3N2O7−, (III] have been determined and their hydrogen-bonded structures are described. In both (II and (III, the DBU cations have a common disorder in three of the C atoms of the six-membered ring moieties [site-occupancy factors (SOF = 0.735 (3/0.265 (3 and 0.686 (4/0.314 (4, respectively], while in (III, there is additional rotational disorder in the DNSA anion, giving two sites (SOF = 0.72/0.28, values fixed for the phenol group. In the crystals of (I and (III, the cation–anion pairs are linked through a primary N—H...Ocarboxyl hydrogen bond [2.665 (2 and 2.869 (3 Å, respectively]. In (II, the ion pairs are linked through an asymmetric three-centre R12(4, N—H...O,O′ chelate association. In (I, structure extension is through amine N—H...Ocarboxyl hydrogen bonds between the PABA anions, giving a three-dimensional structure. The crystal structures of (II and (III are very similar, the cation–anion pairs being associated only through weak C—H...O hydrogen bonds, giving in both overall two-dimensional layered structures lying parallel to (001. No π–π ring associations are present in any of the structures.

  7. Enantioselective synthesis of possible diastereomers of heptadeca-1-ene-4,6-diyne-3,8,9,10-tetrol; putative structure of a conjugated diyne natural product isolated from Hydrocotyle leucocephala.

    Science.gov (United States)

    Prasad, Kavirayani R; Swain, Bandita

    2011-04-01

    Enantioselective synthesis of possible diastereomers of heptadeca-1-ene-4,6-diyne-3,8,9,10-tetrol, a structure proposed for the natural product isolated from Hydrocotyle leucocephala is accomplished. The reported spectral data of the natural product did not match those of any of the isomers that were synthesized and established that the structure proposed for the natural product is not correct and requires revision.

  8. A kidney from hell? A nephrological view of the Whitechapel murders in 1888.

    Science.gov (United States)

    Wolf, Gunter

    2008-10-01

    In the poor Whitechapel district of the East End of London in the fall of 1888, at least five prostitutes were brutally murdered, and in all but one case, also mutilated. The murderer was never caught and became known by his nickname 'Jack the Ripper'. The left kidney and the uterus were cut out and taken away from one of the victims named Catherine Eddowes. A kidney was also cut out of the body from another victim, but not taken away. Two weeks later, George Lusk, president of the Whitechapel Vigilance Committee, received a small cardboard box with half of a longitudinally divided kidney and a letter entitled 'From hell' claiming that the kidney inside the box was taken from the victim. The kidney was brought to Dr Thomas Horrocks Openshaw, the Curator of the London Pathological Museum, where the kidney could be microscopically examined. The press jumped on the topic and made a circumstantial case that this kidney had been indeed torn from the body of Catherine Eddowes. According to the later memoirs of Major Henry Smith of the City Police published more than 20 years after the incident, the kidney left in the corpse of Catherine Eddowes was in an advanced stage of Bright's disease and the kidney sent to George Lusk was in exactly a similar stage. Today, the majority of criminologists believe that the kidney sent to Mr Lusk was a hoax as were other letters signed with Jack the Ripper. However, the murderer took organs from his victims, and in the case of Catherine Eddowes, the kidney. Serial killers often mutilate their victims and abscond with the removed body parts as trophies. By removing the kidney from Catherine Eddowes, Jack the Ripper may have tried to take possession of the conscience, emotions and desires of one of his victims, attributes residing in the kidney as described in the Bible. Jack the Ripper was never caught; many suspects have been suggested, and the murder series ended as suddenly as it had begun. We will never know who this mentally

  9. Stereochemistry of 16a-Hydroxyfriedelin and 3-Oxo-16-methylfriedel-16-ene Established by 2D NMR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Vagner Fernandes Knupp

    2009-02-01

    Full Text Available Friedelin (1, 3b-friedelinol (2, 28-hydroxyfriedelin (3, 16a-hydroxyfriedelin (4, 30-hydroxyfriedelin (5 and 16a,28-dihydroxyfriedelin (6 were isolated through fractionation of the hexane extract obtained from branches of Salacia elliptica. After a week in CDCl3 solution, 16a-hydroxyfriedelin (4 reacted turning into 3-oxo-16-methylfriedel-16-ene (7. This is the first report of a dehydration followed by a Nametkin rearrangement of a pentacyclic triterpene in CDCl3 solution occurring in the NMR tube. These seven pentacyclic triterpenes was identified through NMR spectroscopy and the stereochemistry of compound 4 and 7 was established by 2D NMR (NOESY spectroscopy and mass spectrometry (GC-MS. It is also the first time that all the 13C-NMR and 2D NMR spectral data are reported for compounds 4 and 7.

  10. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Integrated safety assessment of Indian nuclear power plants for extreme events: Reducing impact on public mind · Anil Kakodkar Ram Kumar Singh ... Effect of geological medium on seismic signals from underground nuclear explosion events – A case study for Baneberry site · R K Singh S K Sikka Anil Kakodkar.

  11. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    The Bhuj Earthquake, Gujarat, India, 2001. Guest Editors: Roger Bilham and S. K. Srivastav. pp 129-312 Volume 112 Issue 2 June 2003. Bay of Bengal Monsoon Experiment (BOBMEX) 1999. Guest Editor: D. R. Sikka. pp 187-378 Volume 111 Issue 3 September 2002. Pan Ocean Remote Sensing Conference (PORSEC).

  12. Cyclohex-1-ene carboxylic acids: synthesis and biological evaluation of novel inhibitors of human 5 alpha reductase.

    Science.gov (United States)

    Baston, Eckhard; Salem, Ola I A; Hartmann, Rolf W

    2003-03-01

    In search of novel nonsteroidal mimics of steroidal inhibitors of 5 alpha reductase, 4-(2-phenylethyl)cyclohex-1-ene carboxylic acids 1-5 were synthesized with different substituents in para position of the phenyl ring (1: N, N-diisopropylcarbamoyl, 2: phenyl, 3: phenoxy, 4: benzoyl, and 5: benzyl). The principal synthetic approach for the desired compounds consisted of a Wittig olefination between 1, 4-dioxaspiro [4.5]-decane-8-carbaldehyde (4g and the appropriate phosphonium salts. The compounds were tested for inhibition of human 5 alpha reductase isozymes 1 and 2 using DU 145 cells and preparations from prostatic tissue, respectively. They turned out to be good inhibitors of the prostatic isozyme 2 with compound 1 being the most potent one (IC(50) = 760 nM). Isozyme 1 was only slightly inhibited. It is concluded that the novel structures are appropriate for being further optimized, aiming at the development of a novel drug for the treatment of benign prostatic hyperplasia.

  13. Superhydrophobic and Slippery Lubricant-Infused Flexible Transparent Nanocellulose Films by Photoinduced Thiol-Ene Functionalization.

    Science.gov (United States)

    Guo, Jiaqi; Fang, Wenwen; Welle, Alexander; Feng, Wenqian; Filpponen, Ilari; Rojas, Orlando J; Levkin, Pavel A

    2016-12-14

    Films comprising nanofibrillated cellulose (NFC) are suitable substrates for flexible devices in analytical, sensor, diagnostic, and display technologies. However, some major challenges in such developments include their high moisture sensitivity and the complexity of current methods available for functionalization and patterning. In this work, we present a facile process for tailoring the surface wettability and functionality of NFC films by a fast and versatile approach. First, the NFC films were coated with a layer of reactive nanoporous silicone nanofilament by polycondensation of trichlorovinylsilane (TCVS). The TCVS afforded reactive vinyl groups, thereby enabling simple UV-induced functionalization of NFC films with various thiol-containing molecules via the photo "click" thiol-ene reaction. Modification with perfluoroalkyl thiols resulted in robust superhydrophobic surfaces, which could then be further transformed into transparent slippery lubricant-infused NFC films that displayed repellency against both aqueous and organic liquids with surface tensions as low as 18 mN·m -1 . Finally, transparent and flexible NFC films incorporated hydrophilic micropatterns by modification with OH, NH 2 , or COOH surface groups, enabling space-resolved superhydrophobic-hydrophilic domains. Flexibility, transparency, patternability, and perfect superhydrophobicity of the produced nanocellulose substrates warrants their application in biosensing, display protection, and biomedical and diagnostics devices.

  14. B K Godwal

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. B K Godwal. Articles written in Bulletin of Materials Science. Volume 23 Issue 2 April 2000 pp 151-154 Instrumentation. A CCD area detector for X-ray diffraction under high pressure for rotating anode source · Amar Sinha Alka B Garg V Vijayakumar B K Godwal S K Sikka.

  15. Inspection and monitoring plan, contaminated groundwater seeps 317/319/ENE Area, Argonne National Laboratory

    International Nuclear Information System (INIS)

    1996-01-01

    During the course of completing the Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI) in the 317/319/East-Northeast (ENE) Area of Argonne National Laboratory-East (ANL-E), groundwater was discovered moving to the surface through a series of groundwater seeps. The seeps are located in a ravine approximately 600 ft south of the ANL-E fence line in Waterfall Glen Forest Preserve. Samples of the seep water were collected and analyzed for selected parameters. Two of the five seeps sampled were found to contain detectable levels of organic contaminants. Three chemical species were identified: chloroform (14--25 microg/L), carbon tetrachloride (56--340 microg/L), and tetrachloroethylene (3--6 microg/L). The other seeps did not contain detectable levels of volatile organics. The nature of the contaminants in the seeps will also be monitored on a regular basis. Samples of surface water flowing through the bottom of the ravine and groundwater emanating from the seeps will be collected and analyzed for chemical and radioactive constituents. The results of the routine sampling will be compared with the concentrations used in the risk assessment. If the concentrations exceed those used in the risk assessment, the risk calculations will be revised by using the higher numbers. This revised analysis will determine if additional actions are warranted

  16. Estimación del impacto económico de los museos a través de las nuevas tecnologías de la información: el caso del museo Ene.Térmica

    Directory of Open Access Journals (Sweden)

    Vicente COLL-SERRANO

    Full Text Available Cada vez es más necesario poner de relieve el potencial de la cultura como motor del desarrollo económico y su capacidad para generar ingresos y crear empleo. Por este motivo, en este trabajo se evalúa el impacto económico del museo Ene.Térmica sobre el territorio en el que se ubica, Ponferrada (Comunidad de Castilla y León, España. Para lograr este objetivo, la estimación de los distintos tipos de efectos necesarios para determinar el impacto de las actividades económicas vinculas a la existencia de Ene.Térmica se realiza, en base a la metodología de las Tablas Input-Output, mediante la herramienta Impactrimonio, una aplicación implementada sobre una plataforma web. Los resultados obtenidos indican que entre las actividades del museo y los flujos de demanda desplegados por el efecto arrastre de los visitantes se generó, entre los años 2011 y 2012, un incremento de la producción de más de 15 millones de euros, un incremento de las rentas de la población de casi 10 millones de euros y un aumento de la ocupación de 327 empleos.

  17. Theoretical study on the photolysis mechanism of 2,3-diazabicyclo[2.2.2]oct-2-ene.

    Science.gov (United States)

    Chen, Hui; Li, Shuhua

    2005-09-28

    A CASPT2/CASSCF study has been carried out to investigate the mechanism of the photolysis of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) under direct and triplet-sensitized irradiation. By exploring the detailed potential energy surfaces including intermediates, transition states, conical intersections, and singlet/triplet crossing points, for the first excited singlet (S(1)) and the low-lying triplet states (T(1), T(2), and T(3)), we provide satisfactory explanations of many experimental findings associated with the photophysical and photochemical processes of DBO. A key finding of this work is the existence of a significantly twisted S(1) minimum, which can satisfactorily explain the envelope of the broad emission band of DBO. It is demonstrated that the S(1) (n-pi*) intermediate can decay to the T(1) (n-pi*) state by undergoing intersystem crossing (rather inefficient) to the T(2) (pi-pi*) state followed by internal conversion to the T(1) state. The high fluorescence yield and the extraordinarily long lifetime of the singlet excited DBO are due to the presence of relatively high barriers, both for intersystem crossing and for C-N cleavage. The short lifetime of the triplet DBO is caused by fast radiationless decay to the ground state.

  18. Thiol-ene immobilisation of carbohydrates onto glass slides as a simple alternative to gold-thiol monolayers, amines or lipid binding.

    Science.gov (United States)

    Biggs, Caroline I; Edmondson, Steve; Gibson, Matthew I

    2015-01-01

    Carbohydrate arrays are a vital tool in studying infection, probing the mechanisms of bacterial, viral and toxin adhesion and the development of new treatments, by mimicking the structure of the glycocalyx. Current methods rely on the formation of monolayers of carbohydrates that have been chemically modified with a linker to enable interaction with a functionalised surface. This includes amines, biotin, lipids or thiols. Thiol-addition to gold to form self-assembled monolayers is perhaps the simplest method for immobilisation as thiolated glycans are readily accessible from reducing carbohydrates in a single step, but are limited to gold surfaces. Here we have developed a quick and versatile methodology which enables the use of thiolated carbohydrates to be immobilised as monolayers directly onto acrylate-functional glass slides via a 'thiol-ene'/Michael-type reaction. By combining the ease of thiol chemistry with glass slides, which are compatible with microarray scanners this offers a cost effective, but also useful method to assemble arrays.

  19. Investigation of the fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by certain substituted uracils

    Energy Technology Data Exchange (ETDEWEB)

    Anbazhagan, V. [School of Chemistry, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu (India); Renganathan, R. [School of Chemistry, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu (India)], E-mail: rrengas@yahoo.com

    2009-04-15

    The fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by a series of uracils has been studied in water and acetonitrile solvents using steady-state and time-resolved fluorescence techniques. The steady-state fluorescence quenching technique has been performed in three different pHs (i.e. 4, 8 and 12). The bimolecular quenching rate constant (k{sub q}) increases with increase in pH of uracils. In acidic pH, a pure hydrogen atom abstraction is proposed as the quenching mechanism. This is supported by a pronounced solvent deuterium isotope effect. Electron transfer from the anionic form of uracil to the excited state of DBO is proposed as a mechanism for quenching in basic pH on the basis of highly exergonic thermodynamics obtained from the Rehm-Weller equation. The variation of k{sub q} is explained on the basis of the electronic effect of substitution in uracils as well.

  20. Investigation of the fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by certain substituted uracils

    International Nuclear Information System (INIS)

    Anbazhagan, V.; Renganathan, R.

    2009-01-01

    The fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by a series of uracils has been studied in water and acetonitrile solvents using steady-state and time-resolved fluorescence techniques. The steady-state fluorescence quenching technique has been performed in three different pHs (i.e. 4, 8 and 12). The bimolecular quenching rate constant (k q ) increases with increase in pH of uracils. In acidic pH, a pure hydrogen atom abstraction is proposed as the quenching mechanism. This is supported by a pronounced solvent deuterium isotope effect. Electron transfer from the anionic form of uracil to the excited state of DBO is proposed as a mechanism for quenching in basic pH on the basis of highly exergonic thermodynamics obtained from the Rehm-Weller equation. The variation of k q is explained on the basis of the electronic effect of substitution in uracils as well

  1. The photochemical reaction of 1,1-dicyano-3-phenylbut-1-ene. Simultaneous occurrence of p-methane and di-p-methane rearrangements

    Directory of Open Access Journals (Sweden)

    Silva Francisco A. da

    1999-01-01

    Full Text Available The direct photolysis of 1,1-dicyano-3-phenylbut-1-ene (3-MDCN was investigated at room temperature in solvents of different polarities (hexane, dichloromethane and acetonitrile. Cyclopropanes arising from both the di-pi-methane and pi-methane (1,2-H migration processes were obtained as photoproducts. The structures of the products were elucidated by ¹H-NMR, GC/MS, IR and chromatography. Relative quantum yield determination and GC analysis of sequential irradiations gave evidence that: i no secondary reactions occur, even at high conversions; ii the di-pi-methane rearrangement is significantly more affected by the solvent variation than the pi-methane reaction. Photosensitization with acetophenone or acetone did not yield any observable products. The existence of the simultaneous mechanisms and the observed effects were considered as evidence of a possible differentiation between localized and delocalized excitation on the excited state surface.

  2. Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription.

    Science.gov (United States)

    Osorio, Alex A; Muñóz, Alejandro; Torres-Romero, David; Bedoya, Luis M; Perestelo, Nayra R; Jiménez, Ignacio A; Alcamí, José; Bazzocchi, Isabel L

    2012-06-01

    In the present study we report the isolation of nine new olean-18-ene triterpenes (1-9), along with three known ones (10-12), from Cassine xylocarpa and Maytenus jelskii. Their stereostructures have been elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques (COSY, ROESY, HSQC and HMBC), and spectrometric methods. The natural compounds and derivatives 13-15 have been tested for their potential as inhibitors of human immunodeficiency virus type 1 replication. Five compounds from this series displayed potent antiviral activity with IC(50)s in the micromolar range (1, 3, 4, 7 and 8) being 1 and 8 the most active compounds. The target of these compounds was different from antiretroviral drugs currently licensed as they act as inhibitors of enhancer-dependent transcription. The structure-activity relationships were established based on the regiosubstitution and oxidation degree of the triterpene scaffold, revealing that these aspects were able to modulate the selectivity and intensity of HIV inhibition. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  3. Taotlused ja tulemus / Rein Tootmaa

    Index Scriptorium Estoniae

    Tootmaa, Rein

    2002-01-01

    Helle Karise kavandatava portreefilmide sarja "Contra mortem" esimene film "Dr. Andres Ellamaa" : operaatorid Peter Murdmaa ja Marko Piirsoo : monteerija Eero Karis : produtsendid Helle Karis ja Maret Hirtentreu : kasutatud Carl Orffi muusikat : Myth Film 2002

  4. Doktor Ellamaa elutants / Linnar Priimägi

    Index Scriptorium Estoniae

    Priimägi, Linnar, 1954-

    2002-01-01

    Helle Karise kavandatava portreefilmide sarja "Contra mortem" esimene film "Dr. Andres Ellamaa" : operaatorid Peter Murdmaa ja Marko Piirsoo : monteerija Eero Karis : produtsendid Helle Karis ja Maret Hirtentreu : kasutatud Carl Orffi muusikat : Myth Film 2002

  5. 1,4a-Dimethyl-6-methyl-ene-5-(5,5,6,6-tetra-cyano-2-methyl-cyclo-hex-2-enylmeth-yl)deca-hydro-naphthalene-1-carboxylic acid: a trans-communic acid derivative.

    Science.gov (United States)

    Rejouani, Nezha; Auhmani, Aziz; Ait Itto, My Youssef; Benharref, Ahmed; Daran, Jean-Claude

    2008-01-18

    In the search for cancer chemopreventive agents, we have studied the Diels-Alder reaction of trans-communic acid with tetra-cyano-ethyl-ene in the presence of SiO(2) as catalyst. The title cycloadduct, C(26)H(30)N(4)O(2), was obtained in 75% yield. The mol-ecules are arranged in pairs through O-H⋯O hydrogen bonds, forming an R(2) (2)(8) ring motif. Both the fused cyclohexyl rings adopt a chair conformation, whereas the nonfused ring adopts a half-chair conformation.

  6. Browse Title Index

    African Journals Online (AJOL)

    Items 101 - 111 of 111 ... Vol 3, No 1 (2011), The Ethics of Government Privatisation in Nigeria, Abstract PDF ... Business: Transforming Waste Into Wealth Through The Iko Toilet ... Hell Revisited: Towards a Gentler Theology of Hell, Abstract PDF.

  7. The synthesis of weak acidic type hybrid monolith via thiol-ene click chemistry and its application in hydrophilic interaction chromatography.

    Science.gov (United States)

    Zeng, Jiao; Liu, Shengquan; Wang, Menglin; Yao, Shouzhuo; Chen, Yingzhuang

    2017-05-01

    In this work, a porous structure and good permeability monolithic column was polymerized in UV transparent fused-silica capillaries via photo-initiated thiol-ene click polymerization of 2,4,6,8-tetravinyl-2,4,6,8-tetramethylcyclotetrasiloxane (TMTVS), pentaerythritol tetra(3-mercaptopropionate)(PETMP), itaconic acid, respectively, in the presence of porogenic solvents (tetrahydrofuranand methanol) and an initiator (2,2-dimethoxy-2-phenylacetophenone) (DMPA) within 30 min. The physical properties of this monolith were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and nitrogen adsorption/desorption measurements. For an overall evaluation of the monolith in chromatographic application, separations of polycyclic aromatic hydrocarbons (PAHs), phenols, amides and bases were carried out. The column efficiency of this monolith could be as high as 112 560 N/m. It also possesses a potential application in fabrication of monoliths with high efficiency for c-LC. In addition, the resulting monolithic column demonstrated the potential use in analysis of environment waters. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Äraigatsuse salakajad / Aita Kivi

    Index Scriptorium Estoniae

    Kivi, Aita, 1954-

    2001-01-01

    Sisu : Rein Põder. Hula; David Shahar. Tema majesteedi agent; Stephen Kuusisto. Pimedate planeet; Joanna Trollope. Mehed ja tütarlapsed; Detlef Jena. Venemaa tsaarinnad; Helle Helle. Maja ja kodu; Nick Hornby. Ühest poisist; Deepak Chopra. Eatu keha, ajatu vaim

  9. Comment on "An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model" by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem., 2013, 11, 407.

    Science.gov (United States)

    Zubkov, F I; Kvyatkovskaya, E A; Nikitina, E V; Amoyaw, P N-A; Kouznetsov, V V; Lazarenko, V A; Khrustalev, V N

    2017-08-02

    It has been proved that the reaction between furfuryl amines and N-R-maleimides leads to the formation of aza-Michael addition products - 3-(furylmethylamino)-N-R-pyrrolidine-2,5-diones, instead of 7-oxa-2-azabicyclo[2.2.1]hept-5-enes, as this journal reported previously.

  10. En ansats til en teori om Situationel Dialektisk Ledelse

    DEFF Research Database (Denmark)

    Dakwar, Julia Rytter; Lorentzen, Anne-Christine Rosfeldt; Smedegaard, Flemming

    2015-01-01

    typer af organisations-medlemmer, bl.a. Helle Heins arketypeteori, Thomas Højrups livsformsteori og Helle Petersens cen-lok teori om forandringskommunikation. I en ramme af et dialektisk mindset samles tankerne i artiklens afsluttende afsnit, hvor der skitseres en række krav, som ledelse og ledere i...

  11. Platinum Jubilee of the Indian Academy of Science

    Indian Academy of Sciences (India)

    user

    Platinum Jubilee of the Indian Academy of Science βγ-Crystallins and the bacterial immunoglobulines fold: Two calcium binding folds. Yogendra Sharma. Centre for Cellular and Molecular Biology (CCMB). "Hell is a half-filled auditorium ". Hell is a half-filled auditorium. - Robert Frost (1874-1963) ...

  12. Poly(allyl methacrylate) functionalized hydroxyapatite nanocrystals via the combination of surface-initiated RAFT polymerization and thiol-ene protocol: a potential anticancer drug nanocarrier.

    Science.gov (United States)

    Bach, Long Giang; Islam, Md Rafiqul; Vo, Thanh-Sang; Kim, Se-Kwon; Lim, Kwon Taek

    2013-03-15

    Hydroxyapatite nanocrystals (HAP NCs) were encapsulated by poly(allyl methacrylate) (PolyAMA) employing controlled surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization of allyl methacrylate to afford HAP-PolyAMA nanohybrids. The subsequent thiol-ene coupling of nanohybrids with 2-mercaptosuccinic acid resulted HAP-Poly(AMA-COOH) possessing multicarboxyl group. The formation of the nanohybrids was confirmed by FT-IR and EDS analyses. The TGA and FE-SEM investigation were further suggested the grafting of PolyAMA onto HAP NCs. The utility of the HAP-PolyAMA nanohybrid as drug carrier was also explored. The pendant carboxyl groups on the external layers of nanohybrids were conjugated with anticancer drug cisplatin to afford HAP-Poly(AMA-COOH)/Pt complex. The formation of the complex was confirmed by FT-IR, XPS, and FE-SEM. In vitro evaluation of the synthesized complex as nanomedicine revealed its potential chemotherapeutic efficacy against cancer cell lines. Copyright © 2012 Elsevier Inc. All rights reserved.

  13. Design and fabrication of uniquely shaped thiol-ene microfibers using a two-stage hydrodynamic focusing design.

    Science.gov (United States)

    Boyd, Darryl A; Shields, Adam R; Howell, Peter B; Ligler, Frances S

    2013-08-07

    Microfluidic systems have advantages that are just starting to be realized for materials fabrication. In addition to the more common use for fabrication of particles, hydrodynamic focusing has been used to fabricate continuous polymer fibers. We have previously described such a microfluidics system which has the ability to generate fibers with controlled cross-sectional shapes locked in place by in situ photopolymerization. The previous fiber fabrication studies produced relatively simple round or ribbon shapes, demonstrated the use of a variety of polymers, and described the interaction between sheath-core flow-rate ratios used to control the fiber diameter and the impact on possible shapes. These papers documented the fact that no matter what the intended shape, higher flow-rate ratios produced rounder fibers, even in the absence of interfacial tension between the core and sheath fluids. This work describes how to fabricate the next generation of fibers predesigned to have a much more complex geometry, as exemplified by the "double anchor" shape. Critical to production of the pre-specified fibers with complex features was independent control over both the shape and the size of the fabricated microfibers using a two-stage hydrodynamic focusing system. Design and optimization of the channels was performed using finite element simulations and confocal imaging to characterize each of the two stages theoretically and experimentally. The resulting device design was then used to generate thiol-ene fibers with a unique double anchor shape. Finally, proof-of-principle functional experiments demonstrated the ability of the fibers to transport fluids and to interlock laterally.

  14. Frankensteins uhyre hærger stadig

    DEFF Research Database (Denmark)

    Klitgård, Ida

    2014-01-01

    Anmeldelse af Mary Shelley, Frankenstein, eller den moderne Prometheus (Frankenstein, or the Modern Prometheus), oversat af Jakob Levinsen, med forord af Merete Pryds Helle, Rosinante 2014.......Anmeldelse af Mary Shelley, Frankenstein, eller den moderne Prometheus (Frankenstein, or the Modern Prometheus), oversat af Jakob Levinsen, med forord af Merete Pryds Helle, Rosinante 2014....

  15. Fællesskabende didaktikker

    DEFF Research Database (Denmark)

    Ejersbo, Lisser Rye

    2013-01-01

    Begrebet ’Fællesskabende didaktikker’ er brugt af Helle Plauborg, men som hun skriver udviklet af kollegerne Helle Rabøl Hansen og Dorte Marie Søndergaard, alle tre er forskere indenfor mobning. De er også mine kolleger, og derfor ved jeg, at en vigtig inspirationskilde til dette begreb, viser sig...

  16. Clinical efficacy of implementing Bio Immune(G)ene MEDicine in the treatment of chronic asthma with the objective of reducing or removing effectively corticosteroid therapy: A novel approach and promising results.

    Science.gov (United States)

    Glady, Gilbert

    2018-06-01

    Asthma is one of the diseases that demonstrates a wide range of variation in its clinical expression, in addition to an important heterogeneity in the pathophysiological mechanisms present in each case. The ever-increasing knowledge of the molecular signalling routes and the development of the Bio Immune(G)ene Medicine [BI(G)MED] therapy in line with this knowledge has revealed a whole novel potential set of self-regulation biological molecules, that may be used to promote the physiological immunogenic self-regulation mechanisms and re-establish the homeostatic balance at a genomic, proteomic and cellular level. The aim of the present study is to demonstrate that the sublingual use of a therapeutic protocol based on BI(G)MED regulatory BIMUREGs in the treatment of chronic asthma may reduce or suppress corticosteroid therapy and avoid its harmful side effects which some patients suffer when using this treatment on a long-term basis. The clinical efficacy of BI(G)MED for chronic asthma was evaluated through a multi-centre study carried out in 2016 implementing a 6-month BI(G)MED treatment protocol for Bronchial Asthma. A total of 61 patients from private medical centres and of European countries including Germany, Austria, France, Belgium and Spain participated. The manuscript describes in detail the clinical efficacy of Bio Immune(G)ene regulatory BI(G)MED treatment protocol that allows the reduction or total removal of the corticosteroid dose in patients with chronic asthma. No adverse reactions were observed. The BI(G)MED regulatory therapy brings novel therapeutic possibilities as an effective and safe treatment of chronic asthma. BI(G)MED was demonstrated to significantly reduce asthma severity when parameter compositions were all analysed by categorical outcomes. Therefore, it is considered a good therapeutic alternative for patients who respond poorly to steroids.

  17. Author Meets Readers

    OpenAIRE

    Dan Flory; Leah Kalmanson; Peter K.J. Park; Mark Larrimore; Sonia Sikka

    2017-01-01

    The exchange between Peter Park, Dan Flory and Leah Kalmanson on Park’s book Africa, Asia and the History of Philosophy: Racism in the Formation of the Philosophical Canon (Albany: SUNY Press, 2013) took place during the APA’s 2016 Central Division meeting (Chicago, Illinios) on a panel sponsored by the Committee on Asian and Asian-American Philosophers and Philosophies. After having peer-reviewed the exchange, JWP invited Sonia Sikka and Mark Larrimore to engage with these papers. All the fi...

  18. The Tax Profession: Tax Avoidance and the Public Interest

    OpenAIRE

    Bennett, AnneMarie; Murphy, Breda

    2017-01-01

    Professions possess a service ideal orientation (Dillard 2008; Starr 1982; Toren 1975) and play an important role in the 'pursuit of public interest and the common good’ (Jennings et al. 1987, 3). This incorporates ‘serving the public’ or ‘protecting the public interest’ (Pierce 2007, 7). While there is no agreement on what the ‘public interest’ means or how to measure it (Baker 2005; Boseman 2007; Canning and O’Dwyer 2001; Dellaportas and Davenport 2008; Sikka et al.1989), salient suggestion...

  19. Reaction of singlet-excited 2,3-diazabicyclo[2.2.2]oct-2-ene and tert-butoxyl radicals with aryl-substituted benzofuranones.

    Science.gov (United States)

    Lundgren, Cecilia Vannesjö; Koner, Apurba L; Tinkl, Michael; Pischel, Uwe; Nau, Werner M

    2006-03-03

    5,7-Di-tert-butyl-3-aryl-3H-benzofuran-2-ones are lactones with potential antioxidant activity, owing to their abstractable benzylic C-H hydrogens. The fluorescence quenching of the azoalkane 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO), an established probe for the hydrogen-donor propensity of chain-breaking antioxidants, was investigated for 16 aryl-substituted benzofuranone derivatives [m,m-(CF3)2, p-CN, m-CN, p-CF3, p-COOCH3, m-CF3, p-Cl, p-F, H, m-CH3, p-CH3, m,p-(CH3)2, p-OCH3, o-CH3, o-CF3, o,m-(CH3)2]. Analysis of the rate data in terms of a linear free energy relationship yielded a reaction constant of rho = +0.35. This implies that n,pi*-excited DBO acts as nucleophilic species. In contrast, hydrogen abstraction of tert-butoxyl radicals from the benzofuranones was accelerated by electron-donating substituents (rho = -0.23), in conformity with the electrophilic character of oxygen-centered alkoxyl radicals. Possible implications for the optimization of the hydrogen-donor propensity of antioxidants through structural variation are discussed.

  20. Taler i krisens tegn

    DEFF Research Database (Denmark)

    Hansen, Jette Barnholdt

    2012-01-01

    I dette indlæg anmelder jeg Helle Thorning-Schmidts og Dronning Margrethe II's nytårstaler med særligt fokus på deres mundtlige fremførelse.......I dette indlæg anmelder jeg Helle Thorning-Schmidts og Dronning Margrethe II's nytårstaler med særligt fokus på deres mundtlige fremførelse....

  1. Avaliação de modelos não-lineares e da relação do consumo voluntário de vacas primíparas e de bezerros com a curva de lactação de vacas Nelore Evaluation of non-linear models and the effects of primiparous cows and calves intake on the lactation curve of Nelore cows

    Directory of Open Access Journals (Sweden)

    Lara Toledo Henriques

    2011-06-01

    Full Text Available Procurou-se avaliar a precisão de cinco modelos não-lineares em descrever a forma da curva de produção de leite de vacas Nelore e o efeito do consumo voluntário (CV da vaca e do bezerro sobre a produção de leite (PL. Foram testados os modelos de Sikka, Nelder, Wood, Jenkins & Ferrell, e Jenkins & Ferrell com um parâmetro de ajustamento. Foram utilizadas 12 vacas primíparas com peso corporal médio de 359 kg (± 8 e seus respectivos bezerros. A produção de leite foi estimada pela pesagem do bezerro antes e após a mamada, do nascimento aos 180 dias de idade. As pesagens foram efetuadas duas vezes ao dia, semanalmente, após 6 horas de jejum de líquido e sólidos. Os modelos não-lineares de Sikka, Jenkins & Ferrell, Nelder e Wood não descreveram a curva de lactação apropriada devido ao excesso ou subestimação d o pico da produção de leite. O melhor ajustamento foi encontrado para o modelo de Jenkins & Ferrell com um parâmetro de ajustamento. O efeito do consumo voluntário da vaca e do bezerro, avaliado separadamente, não se correlacionou com a produção de leite. Entretanto, ao avaliar o consumo da vaca e do bezerro conjuntamente, foi encontrada uma correlação positiva e negativa com a produção de leite, respectivamente. A produção de leite está intimamente correlacionada com o consumo da vaca e do bezerro, e a capacidade de ingerir sólidos não lácteos reulta na redução da necessidade de leite da mãe.This research was carried out to evaluate five non-linear mathematical models to describe lactation curves of Nelore cows and effect of the cow and calf intake on milk yield. In this study we compared the models of Sikka (1950, Nelder (1966, Wood (1967, Jenkins & Ferrell (1984 and Jenkins & Ferrell (1984 with a fit parameter. Data of production were collected from 12 primiparous cows with a mean live weight of 359 kg (± 8 and its offspring. The milk production was estimated weighing the calf before and after

  2. Investigations on the fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene by certain flavonoids.

    Science.gov (United States)

    Anbazhagan, V; Kalaiselvan, A; Jaccob, M; Venuvanalingam, P; Renganathan, R

    2008-05-29

    The fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by seven flavonoids namely flavone, flavanone, quercetin, rutin, genistein, diadzein and chrysin has been investigated in acetonitrile and dichloromethane solvents. The bimolecular quenching rate constants lie in the range of 0.09-5.75 x 10(9)M(-1)s(-1) and are explained in terms of structure of the flavonoids studied. The reactivity of flavonoids are in the order: quercetin>rutin>genistein>diadzein>chrysin>flavone>flavanone. The quenching rate constants (k(q)) increase with increase in the number of -OH groups. The endergonic thermodynamic values of DeltaG(et) reveal that electron transfer quenching mechanism can be ruled out. Bond dissociation enthalpy calculations reveal that the position of -OH is important. Further in vitro-antioxidant activities of flavonoids were evaluated with rat liver catalase by gel electrophoresis. The deuterium isotope effect thus observed in this work provides evidence for hydrogen abstraction involved in the quenching process of singlet excited DBO by flavonoids. The data suggest the involvement of direct hydrogen atom transfer (radical scavenging) in the fluorescence quenching of DBO. Bond dissociation enthalpy calculation performed at B3LYP/6-31G(p')//B3LYP/3-21G level are in excellent agreement with the above observations and further reveal that the number OH groups and position of them decide the quenching ability of the flavonoids.

  3. Download this PDF file

    African Journals Online (AJOL)

    enormous pool, a frightening stretch of water, dark green in colour and very deep. In this pool the ... his flesh that is coming back, only his outer self; as for his true self, that has remained ... The imaginative depth in the exploration of a descent into hell, a moral hell. I think .... It assured me total control over my creative space. It.

  4. Thiol-ene and photo-cleavage chemistry for controlled presentation of biomolecules in hydrogels.

    Science.gov (United States)

    Grim, Joseph C; Marozas, Ian A; Anseth, Kristi S

    2015-12-10

    photochemical methods have led to important advances in the tissue regeneration community, namely the thiol-ene photo-click reaction for bioconjugation and photocleavage reactions that allow for the removal of protecting groups. Specific examples will be highlighted where these methodologies have been used to engineer hydrogels that control and direct cell function with the aim of inspiring their use in regenerative medicine. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Jeunes-Turcs et Hellénisme : de l’enthousiasme à la réalité The Young Turks and Hellenism: from enthusiasm to realism

    Directory of Open Access Journals (Sweden)

    Alkistis Sofou

    2012-05-01

    Full Text Available Relations, tensions, oppositions entre les Grecs et les Jeunes-Turcs, entre 1908 et 1914 : la révolution des Jeunes-Turcs a été un tournant dans l’histoire de l’hellénisme. Beaucoup de Rums, malgré quelques voix discordantes, crurent que le nouveau régime poserait les bases d’une collaboration des peuples de l’Empire qui tournerait à leur avantage. Le durcissement progressif de la politique des Jeunes-Turcs dissipa peu à peu ces illusions. Après les défaites et les guerres balkaniques, le gouvernement turc s’orienta vers une politique plus « nationale » : boycott des commerces chrétiens, installation des réfugiés ottomans des Balkans en région à fort pourcentage et chrétien et expulsion violente des Rums des côtes d’Asie Mineure avant même le déclenchement de la Première Guerre mondiale.Relations, tensions, conflicts between the Greek and the Young Turks from 1908 to 1914: the revolution of the Young Turks was a turning point in the history of hellenism. Many Rum, despite some dissenting voices, believed that the new regime would lay the groundwork for collaboration of the people of the Empire to their advantage. The progressive hardening of the Young Turks policy gradually dispelled such illusions. After defeats and the Balkan Wars, the Turkish government turned to a more nationalistic policy: boycotting businesses owned by Christian population and violently expulsion of the Rums from the Asia Minor coast, even before the outbreak of the First World War.

  6. Statistikeren skiftede spor som 49-årig

    DEFF Research Database (Denmark)

    Sølund, Sune; Rootzén, Helle

    2010-01-01

    En uddannelse til coach har ændret Helle Rototzens liv. Som 49-årig forlod hun et forskerliv på deltid til fordel for en karriere som DTU's eneste kvindelige institutdirektør.......En uddannelse til coach har ændret Helle Rototzens liv. Som 49-årig forlod hun et forskerliv på deltid til fordel for en karriere som DTU's eneste kvindelige institutdirektør....

  7. Properties of solid electrolyte interphase formed by prop-1-ene-1,3-sultone on graphite anode of Li-ion batteries

    International Nuclear Information System (INIS)

    Li, Bin; Xu, Mengqing; Li, Benzhen; Liu, Yanlin; Yang, Liang; Li, Weishan; Hu, Shejun

    2013-01-01

    Highlights: • SEI formed by PES on NG was characterized with charge/discharge test, SEM, FTIR, and XPS. • NG in PC-based electrolyte can be well protected using PES. • Sulfur-containing species is the main component of the SEI formed by PES. • Preferable reduction of PES results in the formation of protective SEI on NG. -- Abstract: The physical and chemical properties of the solid electrolyte interphase (SEI) formed by prop-1-ene-1,3-sultone (PES) on graphite anode in propylene carbonate (PC) based electrolyte for lithium ion battery were investigated by charge–discharge test, scanning electron spectroscopy with energy dispersive X-ray spectroscopy (SEM–EDS), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). It is found that the charge–discharge performance of the cell LiCoO 2 /natural graphite (NG) using PC-based electrolyte containing 3 wt% PES is superior to that containing 6 wt% propane sultone (PS), an SEI formation additive that has the similar molecular structure to PES but is reduced not as easily as PES. The results from SEM–EDS, FTIR and XPS show that the structure of graphite has been protected and some S-containing species are proven to be components of the SEI, suggesting that the preferable reduction of PES plays an important role in the formation of a protective SEI on NG

  8. Author Meets Readers

    Directory of Open Access Journals (Sweden)

    Dan Flory

    2017-12-01

    Full Text Available The exchange between Peter Park, Dan Flory and Leah Kalmanson on Park’s book Africa, Asia and the History of Philosophy: Racism in the Formation of the Philosophical Canon (Albany: SUNY Press, 2013 took place during the APA’s 2016 Central Division meeting (Chicago, Illinios on a panel sponsored by the Committee on Asian and Asian-American Philosophers and Philosophies. After having peer-reviewed the exchange, JWP invited Sonia Sikka and Mark Larrimore to engage with these papers. All the five papers are being published together in this issue.

  9. Evaluate Potential Means of Rebuilding Sturgeon Populations in the Snake River between Lower Granite and Hells Canyon Dams, 1997 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Hoefs, Nancy (Nez Perce Tribe, Department of Fisheries Resource Management, Lapwai, ID)

    2004-02-01

    During 1997 the first phase of the Nez Perce Tribe White Sturgeon Project was completed and the second phase was initiated. During Phase I the ''Upper Snake River White Sturgeon Biological Assessment'' was completed, successfully: (1) compiling regional white sturgeon management objectives, and (2) identifying potential mitigation actions needed to rebuild the white sturgeon population in the Snake River between Hells Canyon and Lower Granite dams. Risks and uncertainties associated with implementation of these potential mitigative actions could not be fully assessed because critical information concerning the status of the population and their habitat requirements were unknown. The biological risk assessment identified the fundamental information concerning the white sturgeon population that is needed to fully evaluate the effectiveness of alternative mitigative strategies. Accordingly, a multi-year research plan was developed to collect specific biological and environmental data needed to assess the health and status of the population and characterize habitat used for spawning and rearing. In addition, in 1997 Phase II of the project was initiated. White sturgeon were captured, marked, and population data were collected between Lower Granite Dam and the mouth of the Salmon River. During 1997, 316 white sturgeon were captured in the Snake River. Of these, 298 were marked. Differences in the fork length frequency distributions of the white sturgeon were not affected by collection method. No significant differences in length frequency distributions of sturgeon captured in Lower Granite Reservoir and the mid- and upper free-flowing reaches of the Snake River were detected. The length frequency distribution indicated that white sturgeon between 92 and 183 cm are prevalent in the reaches of the Snake River that were sampled. However, white sturgeon >183 have not changed markedly since 1970. I would speculate that some factor other than past over

  10. IN0523 (Urs-12-ene-3α,24β-diol) a plant based derivative of boswellic acid protect Cisplatin induced urogenital toxicity.

    Science.gov (United States)

    Singh, Amarinder; Arvinda, S; Singh, Surjeet; Suri, Jyotsna; Koul, Surinder; Mondhe, Dilip M; Singh, Gurdarshan; Vishwakarma, Ram

    2017-03-01

    The limiting factor for the use of Cisplatin in the treatment of different type of cancers is its toxicity and more specifically urogenital toxicity. Oxidative stress is a well-known phenomenon associated with Cisplatin toxicity. However, in Cisplatin treated group, abnormal animal behavior, decreased body weight, cellular and sub-cellular changes in the kidney and sperm abnormality were observed. Our investigation revealed that Cisplatin when administered in combination with a natural product derivative (Urs-12-ene-3α,24β-diol, labeled as IN0523) resulted in significant restoration of body weight and protection against the pathological alteration caused by Cisplatin to kidney and testis. Sperm count and motility were significantly restored near to normal. Cisplatin caused depletion of defense system i.e. glutathione peroxidase, catalase and superoxide dismutase, which were restored close to normal by treatment of IN0523. Reduction in excessive lipid peroxidation induced by Cisplatin was also found by treatment with IN0523. The result suggests that IN0523 is a potential candidate for ameliorating Cisplatin induced toxicity in the kidney and testes at a dose of 100mg/kg p.o. via inhibiting the oxidative stress/redox status imbalance and may be improving the efflux mechanism. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Vækstplan DK er en snuptagsløsning

    DEFF Research Database (Denmark)

    Boje Rasmussen, Martin Møller

    2013-01-01

    Med Vækstplan DK har Helle Thorning-Schmidt glemt en socialdemokratisk kongstanke i ambitionen om at skyde hurtig genvej til genvalg. Planen er først og fremmest udtryk for kortsigtet finanspolitik og ikke langsigtet konkurrenceevnepolitik.......Med Vækstplan DK har Helle Thorning-Schmidt glemt en socialdemokratisk kongstanke i ambitionen om at skyde hurtig genvej til genvalg. Planen er først og fremmest udtryk for kortsigtet finanspolitik og ikke langsigtet konkurrenceevnepolitik....

  12. Regulation of a putative corticosteroid, 17, 21-dihydroxypregn-4-ene, 3, 20-one, in sea lamprey, Petromyzon marinus.

    Science.gov (United States)

    Roberts, Brent W.; Didier, Wes; Satbir, Rai; Johnson, Nicholas S.; Libants, Scot V.; Sang-Seon, Yun; Close, David

    2013-01-01

    In higher vertebrates, in response to stress, the hypothalamus produces corticotropin-releasing hormone (CRH), which stimulates cells in the anterior pituitary to produce adrenocorticotropic hormone (ACTH), which in turn stimulates production of either cortisol (F) or corticosterone (B) by the adrenal tissues. In lampreys, however, neither of these steroids is present. Instead, it has been proposed that the stress steroid is actually 17,21-dihydroxypregn-4-ene-3,20-dione (11-deoxycortisol; S). However, there have been no studies yet to determine its mechanism of regulation or site of production. Here we demonstrate that (1) intraperitoneal injections of lamprey-CRH increase plasma S in a dose dependent manner, (2) intraperitoneal injections of four lamprey-specific ACTH peptides at 100 lg/kg, did not induce changes in plasma S concentrations in either males or females; (3) two lamprey-specific gonadotropin-releasing hormones (GnRH I and III) and arginine-vasotocin (AVT), all at single doses, stimulated S production as well as, or to an even greater extent than CRH; (4) sea lamprey mesonephric kidneys, in vitro, converted tritiated 17a-hydroxyprogesterone (17a-P) into a steroid that had the same chromatographic properties (on HPLC and TLC) as S; (5) kidney tissues released significantly more immunoassayable S into the incubation medium than gill, liver or gonad tissues. One interpretation of these results is that the corticosteroid production of the sea lamprey, one of the oldest extant vertebrates, is regulated through multiple pathways rather than the classical HPI-axis. However, the responsiveness of this steroid to the GnRH peptides means that a reproductive rather than a stress role for this steroid cannot yet be ruled out.

  13. Physical Activity

    DEFF Research Database (Denmark)

    Andersen, Lars Bo; Anderssen, Sigmund Alfred; Wisløff, Ulrik

    2014-01-01

    Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers.......Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers....

  14. Selling or telling? A theory of ruin value

    DEFF Research Database (Denmark)

    Pihl, Ole Verner

    2011-01-01

    number of possible apocalyptic scenarios. But what do they tell us these visions of "the end of days" and hell, why are there always demons, flames and fire? Why are hell and heaven always in a different place on the other side, in the after life, is it rather the reverse, that hell is here...... on this planet? War and disasters have a deep impact and are major aesthetic objects of fascination. The Nazi death cult was carefully designed mass propaganda based on a fascinating, mass hysterical carnival of the dead. Architecture and design play an important yet unpleasant part in this.   This paper...... games, comics and films that unfold the aesthetics of the vision of the apocalypse, and the important question, is the message pacifistic or just blind speculation and fascination? Cases on: "Half life 2", "Barefoot Gen", "Akira", "Spawn", "Doom", and "Constantine". 4. Finally, this paper will look...

  15. O sertão amazônico: o inferno de Alberto Rangel The amazonian sertão: the hell of Alberto Rangel

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Coelho de Paiva

    2011-01-01

    Full Text Available A partir da análise do livro de estreia de Alberto Rangel, Inferno verde, publicado em 1908, o artigo busca identificar as motivações e os constrangimentos presentes no processo criativo do autor quanto à formulação de uma representação da Amazônia como sertão. A sua filiação ao estilo de Euclides da Cunha e a sua vinculação ao aparato administrativo estatal quando da sua presença na região confluíram para uma ideia de região então assentada em seu aspecto infernista. O entendimento da realidade nacional a partir dos sertões fez com que a Amazônia fosse tomada pelo autor como um mundo relegado ao esquecimento. Uma interpretação dos diferentes contos do livro e a identificação de uma representação infernista da Amazônia só poderão ser logradas caso leve-se em consideração os aspectos vinculados aos anseios e angústias de Alberto Rangel em tornar-se um escritor e ser reconhecido como tal.Based on the book debut of Alberto Rangel, Inferno Verde (Green Hell, published in 1908, this article investigates the motivations and constraints present in the author's creative process, regarding the representation of the Amazon as sertão (backlands. His adherence to the style of Euclides da Cunha, and his relationship with the state administrative apparatus when he was in the region, contributed to the idea of what seemed to be a hellish aspect of the Amazon. In his understanding of the national reality, in relation to the backlands, the author saw the Amazon as a forgotten world. For a different interpretation of the stories in the book, and the recognition of this hellish representation of the Amazon, it is necessary to take into consideration the aspects related to the aspirations and anxieties of Alberto Rangel on becoming a writer and to be recognized as such.

  16. Ring opening of 2-aza-3-borabicyclo[2.2.0]hex-5-ene, the Dewar form of 1,2-dihydro-1,2-azaborine: stepwise versus concerted mechanisms

    Directory of Open Access Journals (Sweden)

    Holger F. Bettinger

    2013-04-01

    Full Text Available The ring opening of the Dewar form of 1,2-dihydro-1,2-azaborine, 2-aza-3-borabicyclo[2.2.0]hex-5-ene (3 is investigated by theoretical methods by using multiconfiguration SCF (CASSCF and coupled cluster theory [CCSD(T] with basis sets up to polarised quadruple-zeta quality. The title compound was previously reported to form photochemically in cryogenic noble gas matrices from 1,2-dihydro-1,2-azaborine (4. Four reaction paths for the thermal ring opening of 3 to 4 could be identified. These are the conventional disrotatory and conrotatory electrocyclic ring-opening pathways where the BN unit is only a bystander. Two more favourable paths are stepwise and involve 1,3-boron–carbon interactions. The lowest energy barrier for the isomerisation reaction, 22 kcal mol−1, should be high enough for an experimental observation in solution. However, in solution the dimerisation of 3 is computed to have a very low barrier (3 kcal mol−1, and thus 3 is expected to be a short-lived reactive intermediate.

  17. IN0523 (Urs-12-ene-3α,24β-diol) a plant based derivative of boswellic acid protect Cisplatin induced urogenital toxicity

    International Nuclear Information System (INIS)

    Singh, Amarinder; Arvinda, S; Singh, Surjeet; Suri, Jyotsna; Koul, Surinder; Mondhe, Dilip M.; Singh, Gurdarshan; Vishwakarma, Ram

    2017-01-01

    The limiting factor for the use of Cisplatin in the treatment of different type of cancers is its toxicity and more specifically urogenital toxicity. Oxidative stress is a well-known phenomenon associated with Cisplatin toxicity. However, in Cisplatin treated group, abnormal animal behavior, decreased body weight, cellular and sub-cellular changes in the kidney and sperm abnormality were observed. Our investigation revealed that Cisplatin when administered in combination with a natural product derivative (Urs-12-ene-3α,24β-diol, labeled as IN0523) resulted in significant restoration of body weight and protection against the pathological alteration caused by Cisplatin to kidney and testis. Sperm count and motility were significantly restored near to normal. Cisplatin caused depletion of defense system i.e. glutathione peroxidase, catalase and superoxide dismutase, which were restored close to normal by treatment of IN0523. Reduction in excessive lipid peroxidation induced by Cisplatin was also found by treatment with IN0523. The result suggests that IN0523 is a potential candidate for ameliorating Cisplatin induced toxicity in the kidney and testes at a dose of 100 mg/kg p.o. via inhibiting the oxidative stress/redox status imbalance and may be improving the efflux mechanism. - Highlights: • Synthesis of a novel boswellic acid derivative (IN0523) • Counter oxidative stress induced due to Cisplatin • Protect against urogenital toxicity induced by Cisplatin

  18. IN0523 (Urs-12-ene-3α,24β-diol) a plant based derivative of boswellic acid protect Cisplatin induced urogenital toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Amarinder [Academy of Scientific & Innovative Research (AcSIR), New Delhi (India); PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India); Arvinda, S [Deptt. of Pathology, Govt. Medical College, Jammu 180001, J& K (India); Singh, Surjeet [PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India); Suri, Jyotsna [Deptt. of Pathology, Govt. Medical College, Jammu 180001, J& K (India); Koul, Surinder [Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India); Mondhe, Dilip M. [Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India); Singh, Gurdarshan, E-mail: singh_gd@iiim.ac.in [PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India); Vishwakarma, Ram [Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India)

    2017-03-01

    The limiting factor for the use of Cisplatin in the treatment of different type of cancers is its toxicity and more specifically urogenital toxicity. Oxidative stress is a well-known phenomenon associated with Cisplatin toxicity. However, in Cisplatin treated group, abnormal animal behavior, decreased body weight, cellular and sub-cellular changes in the kidney and sperm abnormality were observed. Our investigation revealed that Cisplatin when administered in combination with a natural product derivative (Urs-12-ene-3α,24β-diol, labeled as IN0523) resulted in significant restoration of body weight and protection against the pathological alteration caused by Cisplatin to kidney and testis. Sperm count and motility were significantly restored near to normal. Cisplatin caused depletion of defense system i.e. glutathione peroxidase, catalase and superoxide dismutase, which were restored close to normal by treatment of IN0523. Reduction in excessive lipid peroxidation induced by Cisplatin was also found by treatment with IN0523. The result suggests that IN0523 is a potential candidate for ameliorating Cisplatin induced toxicity in the kidney and testes at a dose of 100 mg/kg p.o. via inhibiting the oxidative stress/redox status imbalance and may be improving the efflux mechanism. - Highlights: • Synthesis of a novel boswellic acid derivative (IN0523) • Counter oxidative stress induced due to Cisplatin • Protect against urogenital toxicity induced by Cisplatin.

  19. Critical Parameters and Critical-Region (p,ρ ,T) Data of trans-1,1,1,3-Tetrafluorobut-2-ene [HFO-1354mzy(E)

    Science.gov (United States)

    Kimura, Takeru; Kayukawa, Yohei; Miyamoto, Hiroyuki; Saito, Kiyoshi

    2017-08-01

    This study presents the experimental measurement of the pρ T properties and critical parameters of a low GWP type refrigerant, trans-1,1,1,3-Tetrafluorobut-2-ene (HFO-1354mzy(E)). The sample purity of the substance was 99 area %. p ρ T property measurements and visual observations of the meniscus of HFO-1354mzy(E) were carried out using a metal-bellows volumometer with an optical cell. The critical temperature was determined by observation of the critical opalescence. The critical pressure and critical density were determined as the inflection point of the isothermal p ρ T property data at the critical temperature. For more precise clarification of the thermodynamic surface in the vicinity of the critical point, additional p ρ T property measurements were carried out on three isotherms in the supercritical region. The expanded uncertainties (k = 2) in the temperature, pressure, and density measurements were estimated to be less than 3 mK, 1.2 kPa, and 0.32 \\hbox {kg} \\cdot \\hbox {m}^{-3}, respectively. The expanded uncertainties of the critical parameters were estimated to be less than 13 mK, 1.4 kPa, and 2.3 \\hbox {kg} \\cdot \\hbox {m}^{-3}, respectively. These values are the first reported for HFO-1354mzy(E) and are necessary for the development of its equation of state in the near future.

  20. 7-{[2-(4-Hydroxyphenylmethylidene]amino}-1,3-thiazol-4-yl-2-(methoxyiminoacetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-ylsulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

    Directory of Open Access Journals (Sweden)

    Ghulam Fareed

    2012-05-01

    Full Text Available Novel 7-{[2-(4-hydroxyphenylmethylidene]amino}-1,3-thiazol-4-yl-2-(methoxyiminoacetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-ylsulfanyl]methyl}-8-oxo-5-thia-1azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid was prepared by condensation of ceftriaxone disodium (1 with 4-hydroxybenzaldehyde (2 in ethanol under reflux conditions for 3–4 h. The structure of synthesized compound was elucidated using LCMS, 1H-NMR, and CHN techniques.

  1. N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry.

    Science.gov (United States)

    Wencewicz, Timothy A; Yang, Baiyuan; Rudloff, James R; Oliver, Allen G; Miller, Marvin J

    2011-10-13

    The discovery, syntheses, and structure-activity relationships (SAR) of a new family of heterocyclic antibacterial compounds based on N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds are described. A structurally diverse library of ∼100 heterocyclic molecules generated from Lewis acid-mediated nucleophilic ring-opening reactions with nitroso Diels-Alder cycloadducts and nitroso ene reactions with substituted alkenes was evaluated in whole cell antibacterial assays. Compounds containing the N-alkyl-N-(pyridin-2-yl)hydroxylamine structure demonstrated selective and potent antibacterial activity against the Gram-positive bacterium Micrococcus luteus ATCC 10240 (MIC(90) = 2.0 μM or 0.41 μg/mL) and moderate activity against other Gram-positive strains including antibiotic resistant strains of Staphylococcus aureus (MRSA) and Enterococcus faecalis (VRE). A new synthetic route to the active core was developed using palladium-catalyzed Buchwald-Hartwig amination reactions of N-alkyl-O-(4-methoxybenzyl)hydroxylamines with 2-halo-pyridines that facilitated SAR studies and revealed the simplest active structural fragment. This work shows the value of using a combination of diversity-oriented synthesis (DOS) and parallel synthesis for identifying new antibacterial scaffolds.

  2. Synthesis of Pyridine and Spiropyridine Derivatives Derived from 2-aminoprop- 1-ene-1,1,3-tricarbonitrile Together with their c-Met Kinase and Antiproliferative Evaluations.

    Science.gov (United States)

    Mohareb, Rafat M; Abouzied, Amr S; Abbas, Nermeen S

    2018-02-07

    Among a wide range of pyridines, 3-cyanopyridines acquired a special attention due to their wide range of pharmacological activities especially the therapeutic activities. Many pharmacological drugs containing the pyridine nucleus were known in the market. The aim of this work was to synthesize target molecules not only possess anti-tumor activities but also kinase inhibitors. To achieve this goal, our strategy was to synthesize a series of 3-cyanopyridine derivatives using 2-aminoprop-1-ene-1,1,3-tricarbonitrile (1) as the key starting material for many heterocyclization reactions. Muticoponent reactions were adopted using compound 1 to get different pyridine derivatives that were capable for different heterocyclization reactions. Antiproliferative evaluations and c-Met kinase, Pim-1 kinse inhibitions were perform where some compounds gave high activities. Compounds that showed high antiprolifeative activity were tested gor c-Met-independent and the results showed that compounds 5c, 5e, 5f, 7c, 7f and 16d were more active than foretinib. The Pim-1 kinase inhibition activity of some selected compounds showed that compounds 5e and 16c were high potent to inhibit Pim-1 activity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  3. Refractive index effects on the oscillator strength and radiative decay rate of 2,3-diazabicyclo[2.2.2]oct-2-ene.

    Science.gov (United States)

    Mohanty, Jyotirmayee; Nau, Werner M

    2004-01-01

    The photophysical properties of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) were determined in 15 solvents, two supramolecular hosts (cucurbit[7]uril and beta-cyclodextrin) as well as in the gas phase. The oscillator strength and radiative decay rate of DBO as a function of refractive index i.e. polarizability have been analyzed. The oscillator strength increases by a factor of 10 upon going from the gas phase to the most polarizable carbon disulfide, while the corresponding radiative decay rates increase by a factor of 40. There is a good empirical correlation between the oscillator strength of the weakly allowed n,pi* transition of DBO and the reciprocal bulk polarizability, which can be employed to assess the polarizability of unknown microheterogeneous environments. A satisfactory correlation between the radiative decay rate and the square of the refractive index is also found, as previously documented for chromophores with allowed transitions. However, the correlation improves significantly when the oscillator strength is included in the correlation, which demonstrates the importance of this factor in the Strickler-Berg equation for chromophores with forbidden or weakly allowed transitions, for which the oscillator strength may be strongly solvent dependent. The radiative decay rate of DBO in two supramolecular assemblies has been determined, confirming the very low polarizability inside the cucurbituril cavity, in between perfluorohexane and the gas phase. The fluorescence quantum yield of DBO in the gas phase has been remeasured (5.1 +/- 0.5%) and was found to fall one full order of magnitude below a previously reported value.

  4. Resolving the Timing of Events Around the Cretaceous-Paleogene Boundary

    Science.gov (United States)

    Sprain, Courtney Jean

    Despite decades of study, the exact cause of the Cretaceous-Paleogene boundary (KPB) mass extinction remains contentious. Hypothesized scenarios center around two main environmental perturbations: voluminous (>10 6 km3) volcanic eruptions from the Deccan Traps in modern-day India, and the large impact recorded by the Chicxulub crater. The impact hypothesis has gained broad support, bolstered by the discoveries of iridium anomalies, shocked quartz, and spherules at the KPB worldwide, which are contemporaneous with the Chicxulub impact structure. However, evidence for protracted extinctions, particularly in non-marine settings, and paleoenvironmental change associated with climatic swings before the KPB, challenge the notion that the impact was the sole cause of the KPB mass extinction. Despite forty years of study, the relative importance of each of these events is unclear, and one key inhibitor is insufficient resolution of existing geochronology. In this dissertation, I present work developing a high-precision global chronologic framework for the KPB that outlines the temporal sequence of biotic changes (both within the terrestrial and marine realms), climatic changes, and proposed perturbations (i.e. impact, volcanic eruptions) using 40Ar/39Ar geochronology and paleomagnetism. This work is focused on two major areas of study: 1) refining the timing and tempo of terrestrial ecosystem change around the KPB, and 2) calibrating the geomagnetic polarity timescale, and particularly the timing and duration of magnetic polarity chron C29r (the KPB falls about halfway into C29r). First I develop a high-precision chronostratigraphic framework for fluvial sediments within the Hell Creek region, in NE Montana, which is one of the best-studied terrestrial KPB sections worldwide. For this work I dated 15 tephra deposits with +/- 30 ka precision using 40Ar/ 39Ar geochronology, ranging in time from 300 ka before the KPB to 1 Ma after. By tying these results to paleontological

  5. Rhodium-catalyzed [5 + 2 + 1] cycloaddition of ene-vinylcyclopropanes and CO: reaction design, development, application in natural product synthesis, and inspiration for developing new reactions for synthesis of eight-membered carbocycles.

    Science.gov (United States)

    Wang, Yi; Yu, Zhi-Xiang

    2015-08-18

    Practical syntheses of natural products and their analogues with eight-membered carbocyclic skeletons are important for medicinal and biological investigations. However, methods and strategies to construct the eight-membered carbocycles are limited. Therefore, developing new methods to synthesize the eight-membered carbocycles is highly desired. In this Account, we describe our development of three rhodium-catalyzed cycloadditions for the construction of the eight-membered carbocycles, which have great potential in addressing the challenges in the synthesis of medium-sized ring systems. The first reaction described in this Account is our computationally designed rhodium-catalyzed two-component [5 + 2 + 1] cycloaddition of ene-vinylcyclopropanes (ene-VCPs) and CO for the diastereoselective construction of bi- and tricyclic cyclooctenones. The design of this reaction is based on the hypothesis that the C(sp(3))-C(sp(3)) reductive elimination of the eight-membered rhodacycle intermediate generated from the rhodium-catalyzed cyclopropane cleavage and alkene insertion, giving Wender's [5 + 2] cycloadduct, is not easy. Under CO atmosphere, CO insertion may occur rapidly, converting the eight-membered rhodacycle into a nine-membered rhodacycle, which then undergoes an easy C(sp(2))-C(sp(3)) reductive elimination process and furnishes the [5 + 2 + 1] product. This hypothesis was supported by our preliminary DFT studies and also served as inspiration for the development of two [7 + 1] cycloadditions: the [7 + 1] cycloaddition of buta-1,3-dienylcyclopropanes (BDCPs) and CO for the construction of cyclooctadienones, and the benzo/[7 + 1] cycloaddition of cyclopropyl-benzocyclobutenes (CP-BCBs) and CO to synthesize the benzocyclooctenones. The efficiency of these rhodium-catalyzed cycloadditions can be revealed by the application in natural product synthesis. Two eight-membered ring-containing natural products, (±)-asterisca-3(15),6-diene and (+)-asteriscanolide, have been

  6. Long-Distance Free Fall

    Science.gov (United States)

    Gallant, Joseph

    1999-04-01

    One of the goals of physics education is to instill a sense of wonder in our students. We hope our natural curiosity will rub off on them and that they will apply the critical thinking skills we teach them to other aspects of their lives outside the classroom. As an example of this, consider the situation described in Milton's epic poem ``Paradise Lost''. Milton wrote that when the devil was cast out of heaven, he fell for nine days before landing in hell. In Milton's universe, hell is a separate place from Earth, but many people place hell at the center of the Earth. Based on these ideas, we can apply Newton's laws of motion to calculate the distance from heaven to Earth. This exercise is an example of the kind of intellectual exercise a physicist (or a physics student) might carry out when confronted with such information. We apply the basic principles of physics to a situation described in work of literature while making no attempt to validate or refute any philosophy, theology or ideology.

  7. Occurrence of (Z)-3,4-Dideoxyglucoson-3-ene in Different Types of Beer and Malt Beer as a Result of 3-Deoxyhexosone Interconversion.

    Science.gov (United States)

    Hellwig, Michael; Nobis, Arndt; Witte, Sophia; Henle, Thomas

    2016-04-06

    In beer, 3-deoxyglucosone (3-DG) and 3-deoxygalactosone (3-DGal) are important sugar degradation products, but little is known about the relevance of the interconversion reaction between these compounds in different types of beer. In the present study, 3-DG was quantitated at concentrations of 12.9-52.7 mg/L and 3-DGal at concentrations of 6.0-26.4 mg/L in different types of beer (pilsner, wheat, bock, dark, and alcohol-free beers). The concentrations in malt beer tended to be higher. Largely overlapping concentration ranges precluded a classification of beers by their 3-deoxyglycosone contents. 3,4-Dideoxyglucoson-3-ene (3,4-DGE) was identified as an important intermediate and quantitated in beer and malt beer for the first time. The E and Z isomers of the corresponding quinoxaline were synthesized by a new synthetic approach and isolated by semipreparative HPLC. An assay was developed for quantitation of (E)- and (Z)-3,4-DGE by HPLC-MS/MS, and the Z isomer was determined at concentrations of 0.3-1.7 mg/L in beer and 0.5-4.8 mg/L in malt beer samples. The E isomer was shown to be of little importance. Concentrations of 5-hydroxymethylfurfural (HMF) were twice as high as those of (Z)-3,4-DGE in beer samples (0.4-3.7 mg/L) but much higher in malt beer samples (1.6-336 mg/L).

  8. Photo-initiated polymerisation of 1,8-octanedithiol and styrene

    International Nuclear Information System (INIS)

    Ang, J.B.; Hill, D.J.T.; Pomery, P.J.; Whittaker, A.K.

    1998-01-01

    Full text: Photo-initiated polymerisation of the thiol-ene system has been well investigated. Its applications include adhesives, coatings and opthalmic lenses. It is unlike the usual UV curable polymeric systems which are predominantly based on acrylates. Typically, acrylate systems are not strictly stoichiometric reactions. The thiol-ene process is a reactive composition based on the stoichiometric reaction of olefins (enes, acrylates) and thiols (mercaptans), which polymerise on exposure to UV light. A unique feature of the thiol-ene system is that the reaction is not inhibited by dissolved or ambient oxygen within the system, thereby eliminating the termination reaction which occurs in acrylate systems. The mechanism of the thiol-ene reaction is a step growth addition process which propagates by a free radical chain mechanism to yield the anti-Markovnikov product scheme. The majority of thiol-ene systems investigated focus on multifunctional moieties of thiol and olefin to produce highly cross-linked networks. This discussion will focus on kinetic information obtained from a linear system comprised of a disfunctional thiol (1,8-octanedithiol) and styrene initiated by a UV light source

  9. Uuslavastused Ugalas / Helle Leppik

    Index Scriptorium Estoniae

    Leppik, Helle

    2007-01-01

    Ugalas käib töö nelja uuslavastusega : Ott Aardam lavastab "Börs ja Börsitar", Helen Rekkor toob lavale "Nora/Maja", Peeter Tammearu suvelavastus on "Sirelikassid" ja Margus Vaher lavastab suvelavastuse "Naabri Mari"

  10. The traditional medicine Spilanthes acmella, and the alkylamides spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, demonstrate in vitro and in vivo anti-malarial activity

    Science.gov (United States)

    Spelman, Kevin; Depoix, Delphine; McCray, Megan; Mouray, Elisabeth; Grellier, Philippe

    2010-01-01

    Spilanthes spp. are used as traditional herbal medicines in Africa and India to treat malaria. Yet, to date, there is no data on active constituents or most effective extraction methods for this indication. The isolated alkylamides, spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, found in S. acmella Murr., were shown to have IC50s of 16.5 μg/mL and 41.4 μg/mL on Plasmodium falciparum strain PFB and IC50s of 5.8 μg/mL and 16.3 μg/mL for the chloroquine resistant P. falciparum K1 strain, respectively. Further investigations revealed that at relatively low concentrations, spilanthol and the water extract of S. acmella reduced the parasitemia 59% and 53% in mice infected with P. yoelii yoelii 17XNL at 5 mg/kg and 50 mg/kg, respectively. Unexpectedly, the 95% ethanol extract of S. acmella was less effective (36% reduction in parasitemia) at 50 mg/kg. These results provide the first evidence supporting S. acmella against malaria and demonstrating active constituents in S. acmella against P. falciparum. PMID:22692989

  11. Limitations on K-T mass extinction theories based upon the vertebrate record

    Science.gov (United States)

    Archibald, J. David; Bryant, Laurie J.

    1988-01-01

    Theories of extinction are only as good as the patterns of extinction that they purport to explain. Often such patterns are ignored. For the terminal Cretaceous events, different groups of organisms in different environments show different patterns of extinction that to date cannot be explained by a single causal mechanism. Several patterns of extinction (and/or preservational bias) can be observed for the various groups of vertebrates from the uppermost Cretaceous Hell Creek Formation and lower Paleocene Tullock Formation in eastern Montana. The taxonomic level at which the percentage of survivals (or extinctions) is calculated will have an effect upon the perception of faunal turnover. In addition to the better known mammals and better publicized dinosaurs, there are almost 60 additional species of reptiles, birds, amphibians, and fish in the HELL Creek Formation. Simple arithmetic suggests only 33 percent survival of these vertebrates from the Hell Creek Fm. into the Tullock Fm. A more critical examination of the data shows that almost all Hell Creek species not found in the Tullock are represented in one of the following categories; extremely rare forms, elasmobranch fish that underwent rapid speciation taxa that although not known or rare in the Tullock, are found elsewhere. Each of the categories is largely the result of the following biases: taphonomy, ecological differences, taxonomic artifact paleogeography. The two most important factors appear to be the possible taphonomic biases and the taxonomic artifacts. The extinction patterns among the vertebrates do not appear to be attributable to any single cause, catastrophic or otherwise.

  12. C60 and Sc3N@C80(TMB-PPO derivatives as constituents of singlet oxygen generating, thiol-ene polymer nanocomposites

    Directory of Open Access Journals (Sweden)

    Ashli R. Toles

    2016-07-01

    Full Text Available Numerous functionalization methods have been employed to increase the solubility, and therefore, the processability of fullerenes in composite structures, and of these radical addition reactions continue to be an important methodology. C60 and Sc3N@C80 derivatives were prepared via radical addition of the photodecomposition products from the commercial photoinitiator TMB-PPO, yielding C60(TMB-PPO5 and Sc3N@C80(TMB-PPO3 as preferred soluble derivatives obtained in high yields. Characterization of the mixture of isomers using standard techniques suggests an overall 1PPO:6TMB ratio of addends, reflecting the increased reactivity of the carbon radical. Although, a higher percentage of PPO is observed in the Sc3N@C80(TMB-PPO3 population, perhaps due to reverse electronic requirements of the substrate. Visually dispersed thiol-ene nanocomposites with low extractables were prepared using two monomer compositions (PETMP:TTT and TMPMP:TMPDE with increasing fullerene derivative loading to probe network structure-property relationships. Thermal stability of the derivatives and the resulting networks decreased with increased functionality and at high fullerene loadings, respectively. TMPMP:TMPDE composite networks show well-dispersed derivatives via TEM imaging, and increasing Tg’s with fullerene loading, as expected for the incorporation of a more rigid network component. PETMP:TTT composites show phase separation in TEM, which is supported by the observed Tg’s. Singlet oxygen generation of the derivatives decreases with increased functionality; however, this is compensated for by the tremendous increase in solubility in organic solvents and miscibility with monomers. Most importantly, singlet oxygen generation from the composites increased with fullerene derivative loading, with good photostability of the networks.

  13. A footnote on the prehistory of interpretation of stellar colours

    Science.gov (United States)

    Brosche, P.

    2001-10-01

    Father Maximilian Hell S.J. (1720-92) was one of the first astronomers to formulate a theory of aurorae. This paper speculates on the possibility that Hell somehow could have associated his theory with the colours of stars, possibly by assuming that in some stellar atmospheres frozen particles are prevailing whereas in other stellar atmospheres water droplets dominate; the first would be more white-yellow, the others could show all colours of the rainbow. Our main point consists in the fact that somebody had seen and recorded colours of stars as an intrinsic phenomenon which called for an explanation.

  14. Derfor svarer politikerne ikke

    DEFF Research Database (Denmark)

    Gabrielsen, Jonas; Jønch-Clausen, Heidi; Pontoppidan, Christina

    2013-01-01

    Helle Thorning-Schmidts beslutning om at droppe det ugentlige tirsdagspressemøde er blevet set som en svækkelse af dialogen mellem journalister og politikere. Spørgsmålet er dog, om ikke journalisterne for længst har undergravet det demokratiske potentiale i tirsdagspressemøderne?......Helle Thorning-Schmidts beslutning om at droppe det ugentlige tirsdagspressemøde er blevet set som en svækkelse af dialogen mellem journalister og politikere. Spørgsmålet er dog, om ikke journalisterne for længst har undergravet det demokratiske potentiale i tirsdagspressemøderne?...

  15. Uptake of Rabies Control Measures by Dog Owners in Flores Island, Indonesia

    Science.gov (United States)

    Wera, Ewaldus; Mourits, Monique C. M.; Hogeveen, Henk

    2015-01-01

    Background Rabies has been a serious public health threat in Flores Island, Indonesia since it was introduced in 1997. To control the disease, annual dog vaccination campaigns have been implemented to vaccinate all dogs free of charge. Nevertheless, the uptake rate of the vaccination campaigns has been low. The objective of this paper is to identify risk factors associated with the uptake of rabies control measures by individual dog owners in Flores Island. Methodology/principal findings A total of 450 dog owners from 44 randomly selected villages in the Sikka and Manggarai regencies were interviewed regarding their socio-demographic factors, knowledge of rabies, and their uptake of rabies control measures. The majority of dog owners surveyed (>90%) knew that rabies is a fatal disease and that it can be prevented. Moreover, 68% of the dog owners had a high level of knowledge about available rabies control measures. Fifty-two percent of the dog owners had had at least one of their dogs vaccinated during the 2012 vaccination campaign. Vaccination uptake was significantly higher for dog owners who resided in Sikka, kept female dogs for breeding, had an income of more than one million Rupiah, and had easy access to their village. The most important reasons not to join the vaccination campaign were lack of information about the vaccination campaign schedule (40%) and difficulty to catch the dog during the vaccination campaign (37%). Conclusions/significance Dog owners in Flores Island had a high level of knowledge of rabies and its control, but this was not associated with uptake of the 2012 vaccination campaign. Geographical accessibility was one of the important factors influencing the vaccination uptake among dog owners. Targeted distribution of information on vaccination schedules and methods to catch and restrain dogs in those villages with poor accessibility may increase vaccination uptake in the future. PMID:25782019

  16. Spectral behavior and photophysical parameters of (2Z)-3-[4-(dimethylamino) phenyl]-2-(4-fluorophenyl) prop-2-ene-nitrile (DPF) in different media

    Energy Technology Data Exchange (ETDEWEB)

    Pannipara, Mehboobali [Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589 (Saudi Arabia); Asiri, Abdullah M. [Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589 (Saudi Arabia); Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, P.O. Box 80203 (Saudi Arabia); Alamry, Khalid A. [Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589 (Saudi Arabia); Salem, Ibrahim A. [Department of Chemistry, Faculty of Science, Tanta University, 31527 Tanta (Egypt); El-Daly, Samy A., E-mail: samyeldaly@yahoo.com [Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589 (Saudi Arabia); Department of Chemistry, Faculty of Science, Tanta University, 31527 Tanta (Egypt)

    2015-01-15

    A new fluorophore, (2Z)-3-[4-(dimethylamino) phenyl]-2-(4-fluorophenyl) prop-2-ene-nitrile (DPF), was synthesized by knoevenagel condensation of 4-(dimethylamino) benzaldehyde and 4-fluorobenzyl cyanide in ethanol using NaOH as base. The electronic absorption and emission characteristic of DPF were studied in different solvents. The X-ray crystallographic structure of DPF was also investigated. DPF exhibits a red-shift in its emission spectrum as solvent polarity increases, indicating a large change in the dipole moment of dye molecule upon excitation due to intramolecular charge transfer in excited DPF{sup ⁎}. The fluorescence quantum yield depends strongly on the properties of the solvents, which was attributed to positive and negative solvatokinetic effects. A crystalline solid of DPF gives a strong yellow emission at about 532 nm; these phenomena are important for the application of DPF dye in organic photoemitting diode. The photochemical quantum yield of cis–trans isomerization of DPF was also determined in different solvents. The DPF dye displays solubilization in both cationic (CTAB) and anionic (SDS) micelle and may be used as a probe to determine the critical micelle concentration (CMC) of SDS and CTAB. - Highlights: • Organic pi conjugated molecule with a donor acceptor group was studied. • Crystalline solid of the molecule shows strong and intense yellow emission. • The dye displays solubilization in cationic micelle with abrupt change in emission intensity at CMC. • This work gives an insight into the application of organic luminescent material in various fields.

  17. Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer.

    Directory of Open Access Journals (Sweden)

    Sura Aziz

    Full Text Available Presence of lymph node (LN metastasis is a strong prognostic factor in breast cancer, whereas the importance of extra-nodal extension and other nodal tumor features have not yet been fully recognized. Here, we examined microscopic features of lymph node metastases and their prognostic value in a population-based cohort of node positive breast cancer (n = 218, as part of the prospective Norwegian Breast Cancer Screening Program NBCSP (1996-2009. Sections were reviewed for the largest metastatic tumor diameter (TD-MET, nodal afferent and efferent vascular invasion (AVI and EVI, extra-nodal extension (ENE, number of ENE foci, as well as circumferential (CD-ENE and perpendicular (PD-ENE diameter of extra-nodal growth. Number of positive lymph nodes, EVI, and PD-ENE were significantly increased with larger primary tumor (PT diameter. Univariate survival analysis showed that several features of nodal metastases were associated with disease-free (DFS or breast cancer specific survival (BCSS. Multivariate analysis demonstrated an independent prognostic value of PD-ENE (with 3 mm as cut-off value in predicting DFS and BCSS, along with number of positive nodes and histologic grade of the primary tumor (for DFS: P = 0.01, P = 0.02, P = 0.01, respectively; for BCSS: P = 0.02, P = 0.008, P = 0.02, respectively. To conclude, the extent of ENE by its perpendicular diameter was independently prognostic and should be considered in line with nodal tumor burden in treatment decisions of node positive breast cancer.

  18. Synthesis and Evaluation of in Vitro Biological Activity of 4-Substituted Arylpiperazine Derivatives of 1,7,8,9-Tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

    Directory of Open Access Journals (Sweden)

    David Collu

    2009-12-01

    Full Text Available A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active against emergent and re-emergent human and cattle infectious diseases (AIDS, hepatitis B and C, tuberculosis, bovine viral diarrhea. In particular, these compounds were evaluated in vitro against representatives of different virus classes, such as a HIV-1 (Retrovirus, a HBV (Hepadnavirus and the single-stranded RNA+ viruses Yellow fever virus (YFV and Bovine viral diarrhea virus (BVDV, both belonging to the Flaviridae. Compounds 2c, 2g and 3d showed a modest activity against CVB-2. The molecular structures of the starting imide 1 and one of propyl-piperazine derivatives, 3b, have been determined by an X-ray crystallography study.

  19. Zinc(II PVC-based membrane sensor based on 5,6-benzo-4,7,13,16,21,24- hexaoxa-1,10-diazabicyclo[8,8,8]hexacos-5-ene

    Directory of Open Access Journals (Sweden)

    Zamani Hassan Ali

    2006-01-01

    Full Text Available The 5,6-benzo-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8,8,8]hexacos-5-ene (BHDE was used as an excellent ionophore in construction of a Zn(II PVC-based membrane sensor. The best performance was obtained with a membrane composition of 30% poly(vinyl chloride, 64.5% nitrobenzen (NB, 2.5% BHDE and 3% sodium tetraphenylborate (NaTPB. This sensor shows very good selectivity and sensitivity towards zinc ion over a wide variety of cations, including alkali, alkaline earth, transition and heavy metal ions. The sensor revealed a great enhancement in selectivity coefficients for zinc ions, in comparison to the previously reported zinc sensors. The proposed sensor exhibits a Nernstian behavior (with slope of 29.1 ? 0.4 mV per decade over a wide concentration range (1.0 10-6-1.0 10-1 mol L-1 with a detection limit of 6.3 x10-7 mol L-1 (41.2 ng mL-1. It shows relatively fast response time, in the whole concentration range (< 10s, and can be used for at least 10 weeks in a pH range of 2.8-7.3. The proposed sensor was successfully used in direct determination of zinc ions in wastewater of industrial zinc electroplating companies, and also as an indicator electrode in titration with EDTA.

  20. Nukulavastus sai Brestis auhinna

    Index Scriptorium Estoniae

    2007-01-01

    Eesti Nuku- ja Noorsooteatri nukulavastus "Tsuhh, tsuhh, tsuhh..." ( autor ja lavastaja Helle Laas) võitis Valgevenes Brestis toimunud rahvusvahelisel teatrifestivalil Belaja Vezha lastelavastuste võistlusprogrammi peapreemia

  1. Televaatajani jõuab kodumaine arstide seriaal / Marii Karell

    Index Scriptorium Estoniae

    Karell, Marii, 1980-

    2002-01-01

    12. veebruaril tutvustab Helle Karis kavandatava portreefilmide sarja "Contra mortem" esimest filmi "Dr. Andres Ellamaa". Sarja eesti arstidest hakatakse alates aprillikuust näitama Eesti Televisioonis

  2. New optically active and thermally stable poly(amide-imide)s containing N,N'-(Bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic)-bis-L-alanine and aromatic diamines: synthesis and characterization

    International Nuclear Information System (INIS)

    Faghihi, Khalil; Absalar, Morteza; Hajibeygi, Mohsen

    2009-01-01

    Five new optically active poly(amide-imide)s (PAIs) 6a-e were prepared by direct polycondensation reaction of the newly synthesized N,N'-(bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetra carboxylic)-bis-L-alanine 4 with various aromatic diamines 5a-e using polar aprotic solvents such as N-methyl-2-pyrrolidone (NMP). In this technique triphenyl phosphite (TPP) and pyridine were used as condensing agents to form poly(amide-imide)s through the N-phosphonium salts of pyridine. All of the polymers were obtained in quantitative yields with inherent viscosities between 0.29-0.46 dL g -1 and were highly soluble in polar aprotic solvents such as N,N-dimethyl acetamide (DMAc), N,N-dimethyl formamide (DMF), dimethyl sulfoxide (DMSO), N-methyl- 2-pyrrolidone (NMP) and solvents such as sulfuric acid. They were fully characterized by means of 1 H NMR, FTIR spectroscopy, elemental analyses, inherent viscosity, solubility test, specific rotation and thermal properties of these polymers were investigated using thermogravimetric analysis techniques (TGA and DTG). (author)

  3. New labdane diterpenes from Solidago canadensis.

    Science.gov (United States)

    Wangensteen, Helle; Phan, Thi T; Rise, Frode; Halvorsen, Trine G; Malterud, Karl E

    2012-01-01

    The ethanol extract of roots of Solidago canadensis yielded eight labdane-type diterpenes. Five of those were new natural compounds (9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3a), 13-epi-9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3b), 15,16-epoxy-labdane-7,13-diene-6,16-dione (5), 15-ethoxy-9,13,15,16-bisepoxy-labdane-7-ene-6-one (6a) and 13-epi-15-ethoxy-9,13,15,16-bisepoxy-labdane-7-ene-6-one (6b). The known labdane diterpenes deoxysolidagenone (1), solidagenone (2) and 15,16-epoxy-labdane-7,13-diene-6,15-dione (4) were also isolated. Chemical structures were determined using 1D and 2D NMR techniques and MS analysis.

  4. Design of peptide substrates for nanosecond time-resolved fluorescence assays of proteases: 2,3-diazabicyclo[2.2.2]oct-2-ene as a noninvasive fluorophore.

    Science.gov (United States)

    Hennig, Andreas; Florea, Mara; Roth, Doris; Enderle, Thilo; Nau, Werner M

    2007-01-15

    Fluorescence protease assays were investigated with peptide substrates containing a 2,3-diazabicyclo[2.2.2]oct-2-ene-labeled asparagine (Dbo) as a fluorescent amino acid. The special characteristic of the fluorophore Dbo is its exceedingly long fluorescence lifetime (ca. 300 ns in water under air), which allows the use of nanosecond time-resolved fluorescence (Nano-TRF) detection to efficiently suppress shorter-lived background emission. In addition, the natural amino acids tryptophan and tyrosine can be employed as intramolecular fluorescence quenchers, which facilitates substrate design. Fourteen synthetic peptide substrates (composed of 2-19 amino acids) and five enzymes (trypsin, pepsin, carboxypeptidase A, leucine aminopeptidase, and chymotrypsin) were investigated and, in all 28 examined combinations, enzymatic activity was detected by monitoring the increase in steady state fluorescence with time and determining the reaction rates as kcat/Km values, which ranged from 0.2 to 80x10(6) M-1 min-1. The results suggest an excellent compatibility of the very small and hydrophilic fluorescent probe Dbo with solid-phase peptide synthesis and the investigated proteases. For all 14 peptides the fluorescence lifetimes before and after enzymatic cleavage were measured and Nano-TRF measurements were performed in 384-well microplates. The fluorescence lifetimes of the different peptides provide the basis for the rational design of Dbo-based fluorescent substrates for protease assays. Measurements in Nano-TRF mode revealed, in addition to efficient suppression of background fluorescence, an increased differentiation between cleaved and uncleaved substrate. The Dbo-based assays can be adapted for high-throughput screening.

  5. New optically active and thermally stable poly(amide-imide)s containing N,N'-(Bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic)-bis-L-alanine and aromatic diamines: synthesis and characterization

    Energy Technology Data Exchange (ETDEWEB)

    Faghihi, Khalil; Absalar, Morteza; Hajibeygi, Mohsen [Arak University (Iran, Islamic Republic of). Faculty of Science. Organic Polymer Chemistry Research Lab.

    2009-07-01

    Five new optically active poly(amide-imide)s (PAIs) 6a-e were prepared by direct polycondensation reaction of the newly synthesized N,N'-(bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetra carboxylic)-bis-L-alanine 4 with various aromatic diamines 5a-e using polar aprotic solvents such as N-methyl-2-pyrrolidone (NMP). In this technique triphenyl phosphite (TPP) and pyridine were used as condensing agents to form poly(amide-imide)s through the N-phosphonium salts of pyridine. All of the polymers were obtained in quantitative yields with inherent viscosities between 0.29-0.46 dL g{sup -1} and were highly soluble in polar aprotic solvents such as N,N-dimethyl acetamide (DMAc), N,N-dimethyl formamide (DMF), dimethyl sulfoxide (DMSO), N-methyl- 2-pyrrolidone (NMP) and solvents such as sulfuric acid. They were fully characterized by means of {sup 1}H NMR, FTIR spectroscopy, elemental analyses, inherent viscosity, solubility test, specific rotation and thermal properties of these polymers were investigated using thermogravimetric analysis techniques (TGA and DTG). (author)

  6. The hell of a radioactivity

    International Nuclear Information System (INIS)

    Lambert, G.

    2004-01-01

    Nuclear accident, contaminations, pollutions and never-ending hazards: nuclear energy and especially radioactivity frightens the collective unconscious in an unreasoned way. The object of this book is to explain in a simple manner the bases and real values of natural radioactivity, nuclear energy and even of nuclear bombs. Without any will of proselytism, but with all the necessary scientific exactness, the author uses a novel style and the fancied story of a young couple for the exploration of the industrial and natural environment of radioactivity. From field measurements to laboratory visits, the reader, whatever his scientific culture, will be able to make his own opinion about this important question of science and society. (J.S.)

  7. Lastekirjandus aabitsast õudusjutuni / Helle Laanpere

    Index Scriptorium Estoniae

    Laanpere, Helle

    2009-01-01

    Arvustus: Lastekirjanduse sõnastik / [Reet Krusten, Krista Kumberg, Mare Müürsepp ... jt. ; toimetajad ja eessõna: Jaanika Palm, Ülle Väljataga]. Tallinn : Eesti Lastekirjanduse Teabekeskus, 2006

  8. Coping with the logistical hell

    DEFF Research Database (Denmark)

    Nielsen, Cathrine Sand; Kramer, Tina; Borgnakke, Karen

    Based on two ethnographic studies in the profession-oriented learning context, the purpose of the presentation is to consider the challenges involved in developing a patient-centered, interprofessional and cross-sectorial study-pathway across health educations. The Ethnographic studies follow...... education together, following a patient pathway through the healthcare sectors. The two ethnographic studies focus on how students and supervisors develope interprofessional competencies and (inter)professional identities. The methodological approach is described as a mix of ethnographic methods (Hammersley...... the practical context, and the fieldwork reflects how the healthcare system is undergoing changes and how the cooperation between professionals and patients is challenged in practical sense. When the leaders and teachers from four different health science programmes, as well as the leaders and clinical...

  9. Arhitektuurikonkurss õnnestus / Tiia-Helle Schmitte

    Index Scriptorium Estoniae

    Schmitte, Tiia-Helle

    2005-01-01

    Arhitektuurivõistlusest, mille eesmärgiks oli saada parim lahendus Mahtra talurahvamuuseumi kaasajastamiseks ja laiendamiseks. Žürii (osalejad loetletud) tunnistas parimaks Tomomi Hayashi ja Hanno Grossschmidti (HG Arhitektuur) võistlustöö. Näitus konkursitöödest oli vaadata muuseumis

  10. Come hell or high water

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Current theory suggests that if the warming effect of the buildup of carbon dioxide and other greenhouse gases reaches the equivalent of twice the preindustrial level, the atmosphere will be committed to warm by 3 to 9 degrees Fahrenheit. At the rate we are now going, that symbolic set point will probably be reached before the middle of the twenty-first century, perhaps before 2030. If fossil fuel combustion were reduced and other complementary measures were taken, that day, of course, could be delayed. No matter what is done now, we can't avoid some future climate change. Even if they were to stop all greenhouse gas emissions tomorrow, we still face an accumulated buildup from the last century whose physical effects won't be fully known at least until the end of this century. A global warming will increase urban ozone levels and the frequency of smog alerts. This chapter explores some of the possible impacts of a rapid global warming. Not all will necessarily occur. Some may be inhibited or aggravated by others, and some may be less severe than the worst scenarios suggest. But the economic costs of even scaled-down damages to human societies and natural ecosystems - which we can do something about - are likely to be tremendous, and the rate of climate change will determine just how serious those damages are

  11. Helle Brabrand body_space_interface

    DEFF Research Database (Denmark)

    Brabrand, Helle

    2016-01-01

    The WEBSITE presents a responsive body-space-media praxis and questions architectonic space-making as a field of artistic research. What are the implications of architectonic modelling, conceived on terms of becoming and in exchange with, but different from actually rising buildings? How to handle...... the complexity of models as performing and presenting agencies and expressions, rather than as re-presenting a building to be? Body_space_interface questions architectural making, asking what kind of world-material may be seized and transformed to produce sensual dimensions in modeling - and vice-versa, which...... you to take part in the above outlined reflections on modeling. It presents different projects as series of both moving and still images that call on improvising rhythm, duration, and order of succession; and it imply resonance and diagram as diverse modes of reflection....

  12. Whats 'App-ening'

    DEFF Research Database (Denmark)

    Ankersen, Dorit V; Weimers, Petra; Burisch, Johan

    2017-01-01

    in number. ehealth helps patients in coping with their disease by promoting self-management, which increases adherence to medical treatment and diets, and leads to an improved quality of life. For irritable bowel syndrome (IBS), there are multiple applications that provide dietary advice, for example, a low...

  13. Repliik / Ene Pajula

    Index Scriptorium Estoniae

    Pajula, Ene, 1950-

    2008-01-01

    Õpilaskodude foorumist ja õpilaskodudest, mis on loodud kodanikualgatuse korras ja nende inimeste tunnustamise vajadusest, tänu kellele meil on kakskümmend kaheksa õpilaskodu, kus elule tagasi võidetud saab nii mõnigi laps

  14. Kuu plaat : Märt Sults "Kõigest koolipapa...". Plaadid kauplusest Lasering

    Index Scriptorium Estoniae

    2005-01-01

    Heliplaatidest : Märt Sults "Kõigest koolipapa...", Madonna "Confessions on a Dance Floor", Tõnis Mägi "Vestlus Hermanniga", Rammstein "Rosenrot", a-ha "Analogue", Darkness "One Way Ticket to Hell...And Back"

  15. Caffeine Effects on Marksmanship During High-Stress Military Training with 72 Hours Sleep Deprivation

    National Research Council Canada - National Science Library

    Tharion, William J; Shukitt-Hale, Barbara; Lieberman, Harris R

    2003-01-01

    Marksmanship accuracy and sighting time were quantified with 62 male trainees during Navy SEAL Hell Week, which involves the combined stress of sleep loss, operational combat scenarios, and cold-wet...

  16. Biostratigraphy and palaeontology of the Scollard Formation, late Cretaceous and Paleocene of Alberta

    National Research Council Canada - National Science Library

    Russell, Loris S

    1987-01-01

    .... The lower portion of the formation contains fossil vertebrates, including dinosaurs and mammals that correlate with those of the Lance Formation of Wyoming and the Hell Creek Formation of Montana...

  17. Ene-ene-yne Reactions: Activation Strain Analysis and Role of Aromaticity

    NARCIS (Netherlands)

    Fernandez, I.; Bickelhaupt, F.M.; Cossío, F.P.

    2014-01-01

    The trend in reactivity of the thermal cycloisomerization reactions of 1,3-hexadien-5-ynes, A=B-C=D-E≡F, were explored and analyzed by using density functional theory at the M06-2X/def2-TZVPP level. These reactions proceed through formally aromatic transition states to form a bent-allene

  18. White Sturgeon Management Plan in the Snake River between Lower Granite and Hells Canyon Dams; Nez Perce Tribe, 1997-2005 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Nez Perce Tribe Resources Management Staff, (Nez Perce Tribe, Department of Fisheries Resource Management, Lapwai, ID)

    2005-09-01

    White sturgeon in the Hells Canyon reach (HCR) of the Snake River are of cultural importance to the Nez Perce Tribe. However, subsistence and ceremonial fishing opportunities have been severely limited as a result of low numbers of white sturgeon in the HCR. Hydrosystem development in the Columbia River Basin has depressed numbers and productivity of white sturgeon in the HCR by isolating fish in impounded reaches of the basin, restricting access to optimal rearing habitats, reducing the anadromous forage base, and modifying early life-history habitats. Consequently, a proactive management plan is needed to mitigate for the loss of white sturgeon production in the HCR, and to identify and implement feasible measures that will restore and rebuild the white sturgeon population to a level that sustains viability and can support an annual harvest. This comprehensive and adaptive management plan describes the goals, objectives, strategies, actions, and expected evaluative timeframes for restoring the white sturgeon population in the HCR. The goal of this plan, which is to maintain a viable, persistent population that can support a sustainable fishery, is supported by the following objectives: (1) a natural, stable age structure comprising both juveniles and a broad spectrum of spawning age-classes; (2) stable or increasing numbers of both juveniles and adults; (3) consistent levels of average recruitment to ensure future contribution to reproductive potential; (4) stable genetic diversity comparable to current levels; (5) a minimum level of abundance of 2,500 adults to minimize extinction risk; and (6) provision of an annual sustainable harvest of 5 kg/ha. To achieve management objectives, potential mitigative actions were developed by a Biological Risk Assessment Team (BRAT). Identified strategies and actions included enhancing growth and survival rates by restoring anadromous fish runs and increasing passage opportunities for white sturgeon, reducing mortality rates

  19. Inert Reassessment Document for Poly(oxyethylene) adducts of mixed phytosterols

    Science.gov (United States)

    Poly(oxyethy1ene) adducts of mixed phytosterols is uncategorized as to list classification status. Based upon the reasonable certainty of no harm safety finding, the List 4B classification for poly(oxyethy1ene) adducts of mixed phytosterols is affirmed.

  20. "Metsluiged" re-edited / S. T.

    Index Scriptorium Estoniae

    S. T.

    2005-01-01

    Helle Karise 1987.a. Hans Christian Anderseni muinasjutu järgi valminud lastefilm "Metsluiged" linastus edukalt Taanis 16. NatFilmi festivalil Anderseni juubeliprogrammis ning ringleb nüüd rahvusvahelistel festivalidel

  1. Popmuusika / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2006-01-01

    Uutest heliplaatidest Jane's Addiction "Up From The Catacombs", Black Label Society "Shot To Hell", Evanescence "The Open Door", Ludacris "Release Therapy", Lionel Richie "Coming Home", "Freerange Records", Ojos De Brujo "Techari"

  2. Seltskond : [fotod] / tekst ja fotod Annika Haas

    Index Scriptorium Estoniae

    2008-01-01

    8. dets. esitles Helle Michelson Eesti Lastekirjanduse Keskuses mälestusteraamatut "Lehitsetud leheküljed: Meenutusi elust ja lastekirjandusest" (Tallinn : Tänapäev, 2008) Kohal viibisid lastekirjanikud Ellen Niit, Jaak Urmet jt.

  3. [Raamat] / Mati Erelt

    Index Scriptorium Estoniae

    Erelt, Mati, 1941-

    1995-01-01

    Arvustus: Metslang, Helle. Temporal relations in the predicate and the grammatical system of Estonian and Finnish : [dissertation]. Oulu : Oulun yliopisto, 1994. (Oulun yliopiston suomen ja saamen kielen laitoksen tutkimusraportteja, ISSN 0356-6773 ; 39)

  4. Heitlikud üheksakümnendad / Pekka Erelt

    Index Scriptorium Estoniae

    Erelt, Pekka, 1965-

    2008-01-01

    Ülevaade sündmustest Eestis 1990ndatel aastatel. Ühel juuresolevatest fotodest president Lennart Meri, proua Helle Meri, USA kaitseminister William Perry ja Eesti suursaadik USAs Toomas Hendrik Ilves 1995. a. novembris

  5. GC-MS study of Nigella sativa (seeds fatty oil

    Directory of Open Access Journals (Sweden)

    Mehta, B. K.

    2002-06-01

    Full Text Available The GC-MS study of N. sativa (seeds fatty oil revealed the presence of 26 compounds which were identified as methyl hept-6-enoate,1-phenylhepta-2,4-dione, pentadecane, hexadec-1-ene, 1-phenyldecan-2-one, octadec-1-ene, octadecane, methyl pentadecanoate, bis(3-chlorophenyl ketone, diethyl phthalate, ethyl octadec-7-enoate, methyl octadecanoate, tricos-9-ene, octadeca-9,12-dienoic acid, hexadecanoic acid, methyl hexadecanoate, methyl octadec-15-enoate, henicosan-10-one, 2-methyl octadecanoic acid, docos-1-ene, ethyl octadecanoate, methyl octadecanoate, pentacos-5-ene,12-methyltricosane, dibutyl phthalate and 2-methyltetracosane.El estudio por GC-MS del aceite de la semilla de Nigella sativa reveló la presencia de 26 compuestos los cuales fueron identificados como: hept-6-enoato de metilo, 1-fenilhepta-2,4-diona, pentadecano, hexadec-1-eno, 1-fenildecan-2-ona, octadec-1-eno, octadecano, pentadecanoato de metilo, bis(3-clorofenil cetona, ftalato de dietilo, octadec-7-enoato de etilo, octadecanoato de metilo, tricos-9-eno, ácido octadeca-9,12-dienoico, ácido hexadecanoico, hexadecanoato de metilo, octadec-15-enoato de metilo, henicosan-10-ona, ácido 2-metil octadecanoico, docos-1-eno, octadecanoato de etilo, octadecanoato de metilo, pentacos-5-eno, 12-metiltricosano, ftalato de dibutilo y 2-metiltetracosano.

  6. Plaadid / Urmas Piht, Katrin Malt, Virko Pirrus...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Uutest heliplaatidest Destruction "D.E.V.O.L. U.T.I.O.N.", Ihsahn "angL", Neuraxis "The Thin Line Between", Kamphar "Heimgang", Satyricon """My Skin Is Cold", Venom "Hell", Bloodbath "The Waken Carnage"

  7. HARMONIC SPACE ANALYSIS OF PULSAR TIMING ARRAY REDSHIFT MAPS

    Energy Technology Data Exchange (ETDEWEB)

    Roebber, Elinore; Holder, Gilbert, E-mail: roebbere@physics.mcgill.ca [Department of Physics and McGill Space Institute, McGill University, 3600 rue University, Montréal, QC, H3A 2T8 (Canada)

    2017-01-20

    In this paper, we propose a new framework for treating the angular information in the pulsar timing array (PTA) response to a gravitational wave (GW) background based on standard cosmic microwave background techniques. We calculate the angular power spectrum of the all-sky gravitational redshift pattern induced at the Earth for both a single bright source of gravitational radiation and a statistically isotropic, unpolarized Gaussian random GW background. The angular power spectrum is the harmonic transform of the Hellings and Downs curve. We use the power spectrum to examine the expected variance in the Hellings and Downs curve in both cases. Finally, we discuss the extent to which PTAs are sensitive to the angular power spectrum and find that the power spectrum sensitivity is dominated by the quadrupole anisotropy of the gravitational redshift map.

  8. Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates

    Directory of Open Access Journals (Sweden)

    Brigita Vigante

    2015-11-01

    Full Text Available The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD in good to excellent yields under mild conditions. The use of TBD is crucial for the successful aminolysis of ethoxycarbonylmethyl ester of 1,4-dihydropyridines with secondary amines as without it the reaction does not proceed at all. The aminolysis reaction proceeded regioselectively, as the alkyl ester conjugated with the 1,4-dihydropyridine cycle was not involved in the reaction. Screening of other N-containing bases, such as triethylamine (TEA, pyridine, 4-(N,N-dimethylaminopyridine (DMAP, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU, 1,5-diazabicyclo[4.3.0]non-5-ene (DBN, imidazole, tetramethyl guanidine (TMG and 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD as catalysts revealed no activity in the studied reaction.

  9. Careers in astronomy in Germany and the UK

    Science.gov (United States)

    Fohlmeister, Janine; Helling, Christiane

    2014-04-01

    Janine Fohlmeister and Christiane Helling discuss the outcomes of surveys addressing the career situation of astronomers in Germany and the UK, finding social and cultural differences between communities as well as gender bias in both.

  10. Kubija Hotell-Loodusspaa = Kubija Hotel-Nature Spa

    Index Scriptorium Estoniae

    2012-01-01

    Võrus Männiku tee 43A asuva Kubija Hotell-Loodusspaa sisekujundusest. Sisearhitektid Tiiu Truus ja Birgit Jaanus (Stuudio Truus). Arhitektid Indrek Tiigi ja Helle-Triin Hansumäe. Loetletud Stuudio Truus tehtud töid

  11. U teatra "Ilmarine" takogo diploma jeshtsho ne bõlo! / Jekaterina Moskalenko

    Index Scriptorium Estoniae

    Moskalenko, Jekaterina

    2000-01-01

    Petrozavodski Rahvusvaheline Kammerlavastuste festivalil (Karjala) sai Narva linnateater "Ilmarine" näidendiga "Brõss v preispodnjuju" kaks diplomit. Muinasjutt-näidendi kohandas Helle Laasi jutustuse järgi teatrile P. Rimski. Lavastaja Juri Mihhaljov

  12. Popmuusika / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2006-01-01

    Uutest heliplaatidest Def Räädu "Succiety", Sepeltura "The BEst Of", "Reich Remixed", Chris Rea "The Road To Hell & Back", Solveig Slettahjell "Good Rain", The Fratellis "Costello Music", Siouxsie And The Banshees "VoicesOn The Air"

  13. Popmuusika / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2005-01-01

    Uutest heliplaatidest The Darkness "One Way Ticket To Hell... And Back", Ryan Adams & The CArdinals "Jacksonvile City Nights", Ammoncontact "New Birth", Shakira "Oral Fixation", Rammstein "Rosenrot", Alanis Morissete "The Collection", Iron Maiden "Death On The Road"

  14. Pop / Aivar Tõnso

    Index Scriptorium Estoniae

    Tõnso, Aivar, 1971-

    2003-01-01

    Heliplaatidest: Plastikman "Closer", A Perfect Circle "Thirteenth Step", UNKLE "Never, Never, Land", Man In Formaldehyde "Copper Sulphate Crystals", Blondie "The Curse Of Blondie", Pantera "Reinventing Hell: The Best of Pantera", Pepe Deluxe "Beatitude", Elvis Costello "North"

  15. Popmuusika / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2006-01-01

    Uutest heliplaatidest 2 Pac "Pac's Life", "Kitsune Maison", Kenny Garrett "Beyond the Wall", Marcus Miller "Power: The Essential Marcus Miller", Clipse "Hell Hath No Fury", Moby "Go ئ The Very Best Of", Ian Archer "Magnetic North"

  16. Vanavara pärastlõuna / Silvia Silvéus

    Index Scriptorium Estoniae

    Silvéus, Silvia, 1926-2016

    2002-01-01

    20. oktoobril 2002 toimunud Sydney Eesti Seltsi Kunsti-ja Käsitööringi ning Eesti Etnograafiaringi Austraalias kultuuripärastlõunal oli vanavara näitus, esitati laule ja tantse, Helle-Mall Risti esines kõnega

  17. Клетка для зверя

    Index Scriptorium Estoniae

    2009-01-01

    Emil Lotjanu filmi "Mu hell ja õrn metsloom" saamislugu (1978). Film põhineb Anton Tšehhovi jutustusel "Draama jahil". Peaosatäitja Galina Beljajeva meenutab. Ka filmi helilooja Jevgeni Doga oma kuulsaks saanud valsi sünniloost

  18. Kontserdisari kutsub "Klavessiinisalongi"

    Index Scriptorium Estoniae

    2008-01-01

    Rakvere Kaurikooli saalis toimuvatest kontsertidest: 7. dets."iViva Espagna!" (esinevad klavessiiniduo Ene Nael - Kristiina Are ja näitleja Tarmo Song), 15. veebr. "Häälemeelne" (laulja Kelli Pärnaste ja kitarrist Tiit Korsar, klavessinist Ene Nael) ja 26. apr. "Fiori musicali" (Tallinna Vanalinna Hariduskolleegiumi, Tallinna Muusikakeskkooli ja Rakvere Kaurikooli klavessiiniõpilased)

  19. Nasha "Russkaja galereja" v Madride

    Index Scriptorium Estoniae

    2005-01-01

    Kaasaegse kunsti laat ARCO Madridis. Osaleb "Vene galerii" Tallinnast näitusega TRINITY. Galerist Masha Melnikova. Osalevad Ene-Liis Semper ja Moskva kunstnikud Anton Litvin ning Bogdan Mamonov. Ene-Liis Semper näitab videokunsti, Anton Litvin fotoprojekti ja Bogdan Mamonov realistlikke portreid. Näitus märtsis Vene saatkonna galeriis Tallinnas

  20. Tere taas, XIII sajand! / Kalle Käsper

    Index Scriptorium Estoniae

    Käsper, Kalle, 1952-

    2002-01-01

    Helle Karise portreefilm alternatiivse meditsiini abil ravitsejast Aleksander Heintalust alias Vigala Sassist : operaatorid Ago Ruus, Peter Murdmaa ja Madis Mihkelsoo : monteerija Eero Karis : kostüümid Mare Raidmalt : kasutatud Veljo Tormise ballaadi "Raua needmine" : Myth Film 2002

  1. Vana-aasta filmiõhtu

    Index Scriptorium Estoniae

    2002-01-01

    Kanal2s oli sügisel telesari eesti tuntud arstidest, keda on filmitud aasta vältel. Helle Karise portreefilmide sarja "Contra mortem" näidatakse ka 30. detsembril Kinomajas filmiõhtul. Kohtuda saab ka arstide endiga

  2. Factors affecting reproduction in Merino ewes of the Tygerhoek flock

    African Journals Online (AJOL)

    ouderdomsgroepe ... paarmassa teen 'n skerper helling toe te neem as by enkelinge. S.-Afr. Tydskr. Veek. 1986, 16: 36 - 42. Keywords: ..... growth and reproductive performance in young sheep given differential nutrition from 9 to 18 months of age.

  3. Generation and analyses of human synthetic antibody libraries and their application for protein microarrays

    DEFF Research Database (Denmark)

    Säll, Anna; Walle, Maria; Wingren, Christer

    2016-01-01

    in a high-throughput manner. To address this we designed and constructed two human synthetic antibody fragment (scFv) libraries denoted HelL-11 and HelL-13. By the use of phage display technology, in total 466 unique scFv antibodies specific for 114 different antigens were generated. The specificities......Antibody-based proteomics offers distinct advantages in the analysis of complex samples for discovery and validation of biomarkers associated with disease. However, its large-scale implementation requires tools and technologies that allow development of suitable antibody or antibody fragments...... for diagnostics and therapeutics. In addition, this work provides a great example on how a synthetic approach can be used to optimize library designs. By having precise control of the diversity introduced into the antigen-binding sites, synthetic libraries offer increased understanding of how different diversity...

  4. Maarjamäe loss (Marienberg) / Robert Gödicke, Nikolai vanem Thamm, Jüri Renter

    Index Scriptorium Estoniae

    Gödicke, Robert

    2004-01-01

    5 välisvaadet, üks 1930. aastast; mõisa ajaloost, omanikest, lossi arhitektuurist, interjöörist, pargist; 1975. a. anti loss üle Eesti Ajaloomuuseumile; hoone restaureeriti aastatel 1983-88 (arhitekt Jüri Renter, sisearhitekt Helle Gans)

  5. Plaat

    Index Scriptorium Estoniae

    2006-01-01

    Laseringi kauplustes müügilolevatest heliplaatidest: J.M.K.E. "Mälestusi Eesti NSV-st", Ladytron "Withing Hour", The Darkness "One Way Ticket To Hell", Popidiot "1111", Eminem "Curtain Call - The Hits", Deep Purple "Rapture Of The Deep"

  6. Obrázky z pekla. Souvislosti několika vyobrazení Posledního soudu z počátku 14. století

    Czech Academy of Sciences Publication Activity Database

    Dienstbier, Jan; Faktor, Ondřej

    2015-01-01

    Roč. 63, č. 6 (2015), s. 434-457 ISSN 0049-5123 R&D Projects: GA ČR GA13-39192S Institutional support: RVO:68378033 Keywords : medieval wall paintings * hell * alewife Subject RIV: AL - Art, Architecture, Cultural Heritage

  7. conference report thai me up, thai me down — the xv ias conference ...

    African Journals Online (AJOL)

    2004-08-01

    Aug 1, 2004 ... makers, network with collaborators, sample the local Asian cuisine, and try to ... Bangkok is hot, bustling and polluted, with traffic from hell; it's also fun, ..... for us were the surprisingly large number of 'data-empty' presentations,.

  8. Microencapsulation of Lithium

    Science.gov (United States)

    1985-12-31

    nuts, chestnuts, f ilberts, hazelnuts, pecans , walnuts (all nuts, in %hells). In other countries, the appropriate government regulatory agencies...75012 Paris, France, 10 Rue Villiot .. ...... . . . . . . 347.87-45 NEAR EAST 20124 Milan, Italy , Via Rosellini 12 ... ...... ...... 688.4563 Hemel

  9. TÜ nõukogu nimetas neli uut professorit ja emeriitdotsendi

    Index Scriptorium Estoniae

    2012-01-01

    TÜ nõukogu valis 2011.a. detsembri istugil professoriteks Helle Karro (sünnitusabi ja günekoloogia alal), Jaak Vilo (bioinformaatika alal), Varmo Vene (programmeerimiskeelte semantika alal), Marlon Dumas (tarkvaratehnika alal) ja emeriitdotsendiks majandusõppejõud Kersti Meiesaar

  10. Chemical constituents from Aspidosperma illustre (Apocynaceae)

    International Nuclear Information System (INIS)

    Barbosa, Lara F.; Mathias, Leda; Braz-Filho, Raimundo; Vieira, Ivo J. Curcino

    2010-01-01

    A new natural product oleanane-type triterpene, olean-12-ene-11α-methoxy-3β-acetate (10) was isolated from Aspidosperma illustre, together with β-amyrin (3), lupeol (4), β-amyrin acetate (5), lupeol acetate (6), olean-12-ene-28-hydroxy-3α-tetradecanoate (7), olean-12-ene-28-carboxy-3α-hexadecanoate (8), ursolic acid (9) triterpenes, and two monoterpenic indole alkaloids, b-yoimbine (1) and 1,2-dehydroaspidospermidine (2). These compounds were characterized on their spectral data basis, mainly one- ( 1 H, 13 C, APT) and two-dimensional ( 1 H- 1 H-COSY, 1 H- 1 HNOESY, HMQC and HMBC) NMR, and mass spectra, involving also comparison with data from the literature. (author)

  11. Three new triterpene esters from pumpkin (Cucurbita maxima) seeds.

    Science.gov (United States)

    Kikuchi, Takashi; Ueda, Shinsuke; Kanazawa, Jokaku; Naoe, Hiroki; Yamada, Takeshi; Tanaka, Reiko

    2014-04-16

    Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2), and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3), were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11)-diene-3α,29-diol 3,29-dibenzoate (4). Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC50 values of 34.5-93.7 μM against HL-60 and P388 cells.

  12. Three New Triterpene Esters from Pumpkin (Cucurbita maxima Seeds

    Directory of Open Access Journals (Sweden)

    Takashi Kikuchi

    2014-04-01

    Full Text Available Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1, 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2, and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3, were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11-diene-3α,29-diol 3,29-dibenzoate (4. Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC50 values of 34.5–93.7 μM against HL-60 and P388 cells.

  13. Mälestis on õpikeskkond / Helle Lepik

    Index Scriptorium Estoniae

    Lepik, Helle

    2016-01-01

    Viimasel aastatel on koostatud põnevaid õppematerjale, mille abil kultuuripärand leiab tee koolitundi. Õppematerjalidega saab tutvuda Muinsuskaitseameti kodulehel http://www.muinas.ee/muinsuskaitsetegevus/haridus Mäluasutustega tutvumiseks on koostatud projekt "Muuseum ja arhiiv õppekeskkonnana". Hermen Rode altariuuringute põhjal valminud teadusveebist. Värske lähenemisega ajalooõppele paistab silma õppematerjal "Ajalooõpetus ja -pildid"

  14. Kips / Pekka Erelt

    Index Scriptorium Estoniae

    Erelt, Pekka, 1965-

    2009-01-01

    Katkendeid Rait Avestiku raamatust "Urmas Kibuspuu 31 aastat" (Tänapäev, 2009). Meenutavad vend Marko Kibuspuu, venna abikaasa Helle, Reet ja Ivo Linna, Ilo Kokamägi, Aarne Üksküla, Anne Paluver, Ago-Endrik Kerge, Elle Kull

  15. Kes kunstnik on selle pildi teinud ? / Riina Noodapera

    Index Scriptorium Estoniae

    Noodapera, Riina, 1952-

    2011-01-01

    Autor selgitab Eesti paadipõgenike foto ajalugu. Samas lisatud ka foto, millel kujutatud Lennart Meri, Christina Anderson, Helle Meri, Ellen Holmert ja Thorsten Andersson. Foto on tehtud 1995. a. seoses Lennart Meri külaskäiguga Gotlandile 1995. a.

  16. Plaadid / Erkki Luuk

    Index Scriptorium Estoniae

    Luuk, Erkki, 1971-

    2005-01-01

    Uutest heliplaatidest "Ulmeralismi tähised", Destiny's Child "Destiny FulFilled", Brian McFadden "Irish Son", dream Theater "Live at Budokan", Meat Loaf "Bat Out Of Hell Life", Axis of Justice "Concert Series vol. 1", Incubus "Alive at Red Rocks"

  17. Huvitav läbikukkumine / Mari Laaniste

    Index Scriptorium Estoniae

    Laaniste, Mari, 1977-

    2006-01-01

    Allan Moore'i ja Eddie Campbelli koomiksil põhinev õuduspõnevik "Otse põrgust" ("From Hell") : režissöörid Allen ja Albert Hughes, peaosas Johnny Depp : Ameerika Ühendriigid - Suurbritannia 2001. Pikemalt A. Moore'ist (s. 1953)

  18. Richard Avedon ja Annie Leibovitz laulsid kaanonit / Marika Alver

    Index Scriptorium Estoniae

    Alver, Marika

    2008-01-01

    Richard Avedoni (1923-2004) retrospektiivnäitusest (fotod aastatest 1946-2004) kuraator Helle Crenzien (Lousiana Kaasaegse Kunsti muuseum Taanis), millega kaasnes ka Helen Whitney film "Richard Avedon : darkness and light" ja Annie Leibovitzi (1949) suurprojektist "A photographer's life 1990-2005" Pariisis

  19. ORIGINAL ARTICLES Staphylococcus aureus skin and soft-tissue ...

    African Journals Online (AJOL)

    (MRSA) has become a key pathogen in skin and soft-tissue infections. (SSTIs). The emergence of ..... SSTI isolates; (iii) improved hospital infection control guidelines and practices to prevent .... So exposed in the field. And he'll never run off ...

  20. Grunge kodukujunduses / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2004-01-01

    Low-tech, campi ja grunge ehitus- ja sisustusstiilidest meil ja mujal - kommenteerivad Andro Kööp ja Ain Nurmela. Tutvustatakse ka Mari-Mira projekti Pariisis, mis kujutab endast nn. mutant-küla, putka- ja onnikultuuri koketeriid. Artikli lõpus kommenteerib kunstiteadlane Karin Paulus grungestiili muusikas, riietuses ja sisekujunduses.

  1. LEADER-tegevusest / Ene Sarapuu

    Index Scriptorium Estoniae

    Sarapuu, Ene

    2009-01-01

    Läänemaa LEADER-tegevusgrupi eesmärk on maakonna kui terviku ühtne areng, et kogu Läänemaa oleks vajalike teenustega kaetud ning ettevõtjad julgeks ning suudaks uute teenuste ja toodetega turule tulla

  2. Environmental Investigations and Analyses for Los Angeles-Long Beach Harbors, Los Angeles, California, 1973-1976.

    Science.gov (United States)

    1976-12-01

    Christine Yonai Fred Piltz Ichthyology Jay Carroll Karl Lyde John Helle Scott Ralston S. Ishikawa Steve Subber Catherine Kusick Catherine Terry...Charles Greaves Catherine Link Susan Harrison Julie Thompson Kaoru 0. Kendis Ismay Stanley Randall Kendis Marine Technicians Bruce Adams Gene Mummert

  3. Pärnu uued majad väljakujunenud linnaruumis / Anni Nool

    Index Scriptorium Estoniae

    Nool, Anni

    2006-01-01

    Jannseni ja Jaani tänava nurgamaja (Hardi Lehemaa, Helle-Ann Urgard). Tallinna mnt. ja Rohu tänava nurgamaja (Rein Raie). Aisa tänava kortermaja (arhitektuuribüroo Luhse ja Tuhal). Kommenteerivad Liis Keskküla ja Üllar Hinno

  4. Oral Tradition as the Literary Skeleton of African Novels: A Study of ...

    African Journals Online (AJOL)

    s way of life, often expressed in what they do (social functions and roles); what they think (their philosophy of life about birth, death, God, heaven, hell, health, ancestors, wealth, poverty etc) and what they have (the material aspects of culture ...

  5. Global biogeography and evolution of Cuvierina pteropods

    NARCIS (Netherlands)

    Burridge, A.K.; Goetze, E.; Raes, N.; Huisman, J.; Peijnenburg, K.T.C.A.

    2015-01-01

    Background: helled pteropods are planktonic gastropods that are potentially good indicators of the effects of ocean acidification. They also have high potential for the study of zooplankton evolution because they are metazoan plankton with a good fossil record. We investigated phenotypic and genetic

  6. V V Raman is Emeritus Professor of Physics and Humanities at the ...

    Indian Academy of Sciences (India)

    edu http://en.wikipedia.org/wiki/Varadaraja_V. _Raman petty piece of charcoal; rubies, sapphires and emeralds would all be dark as the depths of hell. The effect of light on the world around us is of incredible variety. The magnificent aurora and.

  7. Avalik pöördumine seoses Kihnu rahvamajaga / Toomas Rein, Leonhard Lapin

    Index Scriptorium Estoniae

    Rein, Toomas, 1940-

    2001-01-01

    Eskiisprojektist, Arhitektuuribüroo Toomas Rein poolt 31. V 2000. a. Kihnu vallavalitsusele üle antud tehnilisest projektist (arhitektid T. Rein, L. Lapin, sisearhitekt Helle Gans), ehitaja riigihankekonkursist, ehitusfirma FKSM tööjooniste ja valmishoone erinevusest tehnilisest projektist, autoriõigusest jm

  8. Keemia- ja füüsikapreemiate märksõna on valgus / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2014-01-01

    Nobeli keemiapreemia pälvisid sakslane Stefan Hell ning ameeriklased Eric Betzig ja William Moerner, kes leidsid viisi, kuidas uurida valgusmikroskoobiga eluslooduse pisimaid komponente. Füüsikapreemia pälvisid Jaapani teadlased Isamu Akasaki, Hiroshi Amano ja Shuji Nakamura sinise valgusdioodi leiutamise eest

  9. ISLAM IN THE NON-MUSLIM AREAS OF NORTHERN NIGERIA, c

    African Journals Online (AJOL)

    QUADRI Y A

    the logic/sense in believing heaven/hell real or otherwise. It indicates that heaven ..... are serious objects of human affection—trying “to satisfy infinite needs with finite entities” in a ... he were drowned in the depths of the sea. 40. Interestingly ...

  10. Urknall im labor: das grösste experiment der welt entsteht bei Genf - unter der erde

    CERN Multimedia

    2006-01-01

    The Big Bang in the laboratory has only few more energy than two colliding mosquitoes. But if we put together billions of mosquitoes, a hell bursts out. For that, near Geneva the biggest experiment in the world is being built.(1,2 page)

  11. Hõivatute edetabelisse jõudis kolm meest Ugalast / Tea Raidsalu

    Index Scriptorium Estoniae

    Raidsalu, Tea

    2009-01-01

    Postimehe nädalalõpulisa "Arter" kõige hõivatumate näitlejate loendis on Ugalast Tanel Ingi, Arvo Raimo ja Arvi Mägi. Andmeid nimekirja koostamiseks andsid teatrite trupijuhid. Ugala näitlejate kaalukamate rollide väljaselgitamist kommenteerib kirjandustoimetaja Helle Leppik

  12. Hvis Thorning var CEO

    DEFF Research Database (Denmark)

    Boje Rasmussen, Martin Møller

    2013-01-01

    Helle Thorning-Schmidt er som statsminister blevet konfronteret med de samme syv overraskelser, som ifølge strategi- og ledelsesguruen Michael Porter udfordrer enhver nyudnævnt topleder. Regeringens fortsatte overlevelse afhænger af, hvor hurtigt statsministeren erkender det og handler....

  13. Chemical Constituents from Bombacopsis glabra (Pasq. A. Robyns: Complete 1H and 13C NMR Assignments and X Ray Structure of 5-Hydroxy-3,6,7,8,4'-pentamethoxyflavone

    Directory of Open Access Journals (Sweden)

    Paula Vanderlúcia F.

    2002-01-01

    Full Text Available The flavone 5-hydroxy-3,6,7,8,4'-pentamethoxyflavone (1 and the triterpenes lupenone, 9,19-cyclolanost-23-ene-3beta,25-diol (2, (24R-9,19-cyclolanost-25-ene-3beta,24-diol (3 and (24S-9,19-cyclolanost-25-ene-3beta,24-diol (4 were isolated from the hexane extract of the stem bark of Bombacopsis glabra (Bombacaceae. The structures were determined by 13C and ¹H NMR (1D and 2D and mass spectrometry, and by comparison with literature data for triterpenes. The structure of the flavone 1 was unambiguously confirmed by a X-ray diffraction study. The five substances were isolated for the first time from Bombacaceae species.

  14. Situación de riesgo y salud de los adolescentes en el valle de los ríos Apurímac, Ene y Mantaro en Perú

    Directory of Open Access Journals (Sweden)

    Fabiola Yeckting Vilela

    Full Text Available Se presenta el diagnóstico de las condiciones de vida de los adolescentes varones y mujeres en la zona del valle de los ríos Apurímac, Ene y Mantaro (VRAEM, quienes atraviesan situaciones de riesgo y vulnerabilidad social y sexual debido a los altos niveles de producción de la hoja de coca y el contexto del narcotráfico, que crean la ilusión del rápido ascenso social. A partir de ello, es necesario preguntarse ¿cuáles son las condiciones de vida y situaciones de riesgo de los adolescentes en el VRAEM? y ¿cuáles son las alternativas para una mejora de su situación desde el acceso a la educación y los programas de atención de su salud? Esta situación de riesgo es el resultado de las relaciones desiguales de género, violencia sexual, deserción escolar, embarazo adolescente, consumo de alcohol y drogas, así como de la falta de oportunidades como consecuencia de la participación en la economía de la coca y el narcotráfico entre los adolescentes en el VRAEM. Finalmente, se presentan los resultados de la atención de profesionales de los centros de salud para favorecer la consejería en salud sexual y reproductiva y el acceso a los servicios de salud del Programa Vida Adolescente, como oportunidad de vincular los contenidos del currículo de educación y las metas de cumplimiento de este sector, visibilizando la necesidad de un enfoque de interculturalidad e igualdad de género en el acceso a la salud y la educación de los adolescentes.

  15. Socialt entreprenørskab på RUC

    DEFF Research Database (Denmark)

    ; Social Impact Measurement and finding a balance between academic criteria and professional relevance. Helle Hygum Espersen: At kvalificere samskabelses-dagsordenen i en kommune - overvejelser over mulige afgørende principper. Stine Skov Øllgård Efter-videreuddannelsesstrukturer – et afgørende parameter...

  16. Storyline as a Space for Simulated Practice

    DEFF Research Database (Denmark)

    Lund, Birthe; Tang Jørgensen, Lone; Pagh Fisker, Helle

    2016-01-01

    Omhandler brugen af StoryLine som et undervisningsmæssigt eksperiment i pædagoguddannelsen som eksempel på et simuleret rum med henblik på at forbinde teori og praksis i undervisningen. Medforfattere: LONE TANG JORGENSEN, HELLE PAGH FISKER AND HENRIETTE SKAARUP GEJEL JENSEN...

  17. "7 vaprat" ei lõpeta ka suvel / H. S.

    Index Scriptorium Estoniae

    H. S.

    2002-01-01

    Populaarne muusikaedetabelisaade "7 vaprat" läheb juunis ansamblitega Terminaator, Tuberkuloited, No Big Silence, Blacky, Speed Free ja Hell Can Wait suvetuurile. 11. juunil antakse kontsert Tartus, 12. juunil Rakveres, 13. juunil Pärnus ja 15. juunil Tallinnas. Kontsertidest valmivad ka telesaated, saatejuht Villu Tamme

  18. Enam-vähem otse põrgust / Mari Laaniste

    Index Scriptorium Estoniae

    Laaniste, Mari, 1977-

    2002-01-01

    Mängufilm "Põrgust" ("From Hell") : režissöörid Albert ja Allen Hughes : Ameerika Ühendriigid - Tšehhi Vabariik 2001. Analüüsitud filmi lähtekohaks olnud Alan Moore'i 1988. a. ilmunud raamatu, selle varasemate eeskujude ja filmi vahekorda

  19. Senior High School English National Examination and Thinking Skills

    Directory of Open Access Journals (Sweden)

    Ummu Lathifah Ahmad

    2016-12-01

    Full Text Available When English National Examination (abbreviated into ENE as a norm-referenced test is designed for instructional purposes, to evaluate the result of national curriculum, it is very significant to conduct item test evaluation since it gives a clear portrait of the quality of the items and of the test as a whole. The purpose of this study was to analyze which levels of the Barrett taxonomy were more reflected in ENE items of 2013/2014 academic year and whether the proportions of items among the twenty test packages in the ENE assessing students’ Lower Order Thinking Skills (LOTS and Higher Order Thinking Skills (HOTS are consistent. The researcher adopted the qualitative descriptive approach using a content analysis card to codify the ENE items. To ensure the reliability of the study, three inter-raters analyzed a sample of the test packages. The results indicated that questions asking LOTS still prevailed in ENE items. Of all the twenty test packages, the items categorized into literal level represented around 68.6% of the total number of the questions. Meanwhile, the questions belonging to reorganization came to occupy a percentage of 20.8 and the questions asking the students’ inferential level only reached 10.3%. Also, the tests were not enriched sufficiently with the evaluation comprehension since they only comprised 0.3%. The results also showed the complete absence of “Appreciation” – the highest level of thinking in the mentioned taxonomy. It is obvious that there is a shortage of items questioning students’ HOTS in the exam and they are not well-treated. Accordingly, this finding reveals that there is still much room for ENE to be the driving force in the effort to make learners critical thinkers. In the light of these data, this study recommends modifying the English National Exam by providing them with more question items that include HOTS.

  20. Synthesis, characterization and anticancer studies of new steroidal oxadiazole, pyrrole and pyrazole derivatives

    Directory of Open Access Journals (Sweden)

    Shamsuzzaman

    2015-07-01

    Full Text Available In the present study steroidal derivatives, 3β-[5′-mercapto-1′,3′,4′-oxadiazole-2-yl]methoxy cholest-5-ene 2, 3β-[2′,5′-dimethylpyrrole-1-yl]aminocarbonylmethoxycholest-5-ene 3 and 3β-[3′,5′-dimethyl pyrazole-1-yl]carbonylmethoxycholest-5-ene 4 have been synthesized from cholest-5-en-3β-O-acetyl hydrazide 1 using CS2/KOH, acetonyl acetone and acetyl acetone, respectively as reagents and are characterized by IR, 1H NMR,13C NMR, MS and elemental analysis. Compounds 2–4 were also evaluated for anticancer activity against human leukemia cell line (HL-60 by MTT assay and compound 4 displayed the promising behavior by showing better anticancer activity.

  1. The Rise And Fall Of The Afterlife : The 1995 Read-Tuckwell Lectures at the University of Bristol

    NARCIS (Netherlands)

    Bremmer, Jan N.

    2002-01-01

    The afterlife is still very much alive in Western civilisation, even though the truth of its existence is no longer universally accepted. Surprisingly, however, heaven, hell and the immortal soul were all ideas which arrived relatively late in the ancient world. Originally Greece and Israel - the

  2. Vertigo substriata Jeffreys, faunae neerlandicae nova species, een zoogenaamd glaciaalrelikt

    NARCIS (Netherlands)

    Sunier, A.L.J.

    1926-01-01

    I. HET NEDERLANDSCHE MATERIAAL VAN VERTIGO SUBSTRIATA JEFFR.. Onder het vaak interessante materiaal van Nederlandsche Mollusca, dat den laatsten tijd door de Heeren W. F. van Hell en J. A. Nijkamp, studenten in de biologie te Leiden, aan 's Rijks Museum van Natuurlijke Historie werd afgestaan, trof

  3. Within- and between-season repeatability of eggshell colouration in the great reed warbler Acrocephalus arundinaceus

    Czech Academy of Sciences Publication Activity Database

    Honza, Marcel; Procházka, Petr; Požgayová, Milica

    2012-01-01

    Roč. 43, č. 1 (2012), s. 91-96 ISSN 0908-8857 R&D Projects: GA AV ČR IAA600930903 Institutional research plan: CEZ:AV0Z60930519 Keywords : Acrocephalus arundinaceus * eggs hell coloration * repeatability Subject RIV: EG - Zoology Impact factor: 2.020, year: 2012

  4. Reply to the comment by Thorsen et al. on "Diverging incentives for afforestation from carbon sequestration: An economic analysis of the EU afforestation program in the south of Italy"

    NARCIS (Netherlands)

    Tassone, V.C.; Wesseler, J.H.H.; Nesci, F.S.

    2006-01-01

    In their comment Thorsen, Strange, and Helles (this journal) suggest that the model we use in our paper "Diverging incentives for afforestation from carbon sequestration: an economic analysis of the EU afforestation program in the south of Italy." Forest Policy and Economics 6, 567-578 includes a

  5. Turistid-sõjaõhutajad : dessant Iisraeli / Karin Hallas

    Index Scriptorium Estoniae

    Hallas, Karin, 1957-

    1999-01-01

    Kultuuridessandist Marika Valgu ja Helle Puusepaga Iisraeli. Jeruusalemma Yad Vashemist ئ Holocausti muuseumist. Arhitekt Moshe Safdie Laste Memoriaali ja Yad Vashemi memoriaali uue hoone lahendusest. Tel Avivi ja Jeruusalemma arhitektuurist ئ funktsionalismist, praegusest arhitektuurist, arhitekte. James Turrelli kunstiteosest "Ruum, mis näeb" Jeruusalemma muuseumi pargis

  6. Presidendi valimine - erakondade konsensuspoliitika proovikivi / interv. Aivar Jarne

    Index Scriptorium Estoniae

    2006-01-01

    Konsensuskandidaadi otsimisest ja presidendi valimise võimalikkusest Riigikogus, valimiskampaaniast, seostest kohalike ja Riigikogu valimistega, meedia rollist, presidendi institutsioonist tulevikus ning võimalustest muuta presidendi valimise korda. Vestlusringis osalevad: Rain Rosimannus, Eiki Nestor, Vello Pettai, Agu Uudelepp ja Argo Ideon. Valiku vestlusest tegi Riigikogu Toimetiste peatoimetaja Helle Ruusing

  7. Effect of tibolone and its principal metabolites (3α- and 3β-hydroxy, 3α-sulfate, and 4-ene derivatives) on estrone sulfatase activity in normal and cancerous human breast tissue.

    Science.gov (United States)

    Chetrite, Gérard S; Cortes-Prieto, Joaquin; Pasqualini, Jorge R

    2011-12-01

    Tibolone (Org-OD14) is the active substance of Livial®, a synthetic steroid with the structure 7α,17α-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one, possessing weak tissue-specific estrogenic, progestogenic, and androgenic properties, used to treat menopausal complaints. After oral administration, tibolone is extensively metabolized into the 3α-(Org-4904) and 3β-(Org-30126) hydroxy derivatives with estrogenic properties, its 4-ene (Org-OM38) isomer with progestogenic/androgenic activities, and the 3α-sulfate (Org-34322) derivative, a major biologically inactive circulating form. We compared the dose response of tibolone and its metabolites on estrone sulfatase activity [conversion of estrone sulfate (E1S) to estrone (E1)] in normal and cancerous human breast tissues. Tissue minces were incubated with physiological concentrations of [3H]-E1S (5×10-9M) alone or in the presence of tibolone and its metabolites (concentration range: 5×10-7to 5×10-5M) for 4 h. Tritiated E1, estradiol (E2), and E1S were separated and evaluated quantitatively by thin-layer chromatography. The sulfatase activity was significantly higher in cancerous breast but strongly inhibited by tibolone and the different metabolites, whereas 3α- and 3β-hydroxy derivatives were the most potent inhibitors. This very significant inhibitory effect of tibolone and its principal metabolites on the enzyme involved in E2biosynthesis in the human breast provides interesting perspectives to study the biological responses of these compounds in trials with breast cancer patients.

  8. Diosas de la montaña, espíritus tutelares, seres con máscaras vegetales y chamanes sobre árboles en el arte rupestre levantino español (Sureste de la Península Ibérica

    Directory of Open Access Journals (Sweden)

    Juan Francisco JORDÁN MONTÉS

    2009-12-01

    Full Text Available RESUMEN: Propuestas de interpretación, desde perspectivas antropológicas, para algunas escenas del arte rupestre levantino español, en la estaciones rupestres de Solana de las Covachas (Nerpio, Cerro Barbatón (Letur, El Milano (Mula, Peña Rubia (Cehegín, Minateda (Hellín, cueva de la Vieja (Alpera y Alcaine (Teruel. Se destaca la probable narración de mitos en los que participaban diosas de las montañas y chamanes.RÉSUMÉ: Propositions d'interprétation, du point de vue des perspectives anthropologiques, pour quelques scènes de Tart rupestre du Levant Espagnol, dans les station rupestres de Solana de las Covachas (Nerpio, Cerro Barbatón (Letur, el Milano (Mula, Peña Rubia (Cehegín, Minateda (Hellín, CUeva de la Vieja (Alpera et Alcaine (Teruel. Il se détache la narration probable de mythes ou participaient des déesses de la montagne et des chamans.

  9. Proof of the Structure of the Stemodia chilensis Tetracyclic Diterpenoid (+)-19-Acetoxystemodan-12-ol by Synthesis from (+)-Podocarpic Acid: X-ray Structure Determination of a Key Intermediate.

    Science.gov (United States)

    Leonelli, Francesca; Mostarda, Azzurra; De Angelis, Luca; Lamba, Doriano; Demitri, Nicola; La Bella, Angela; Ceccacci, Francesca; Migneco, Luisa M; Marini Bettolo, Rinaldo

    2016-04-22

    The first synthesis of (+)-19-acetoxystemodan-12-ol (1), a stemodane diterpenoid isolated from Stemodia chilensis, is described. The structure was supported by an X-ray crystallographic analysis of intermediate (+)-9a, which confirmed the proposed structure and excluded the structure of (-)-19-hydroxystemod-12-ene as a possible candidate for the Chilean Calceolaria diterpenoid to which the (-)-19-hydroxystemar-13-ene structure (9b) had been erroneously assigned.

  10. Plaadid / Priit Juurmann

    Index Scriptorium Estoniae

    Juurmann, Priit

    2005-01-01

    Uutest heliplaatidest Nicole Willis and The Soul Investigators "Keep Reachin' Up", Pricess Superstar "My Machine", The Darkness "One Way Ticket To Hell...And Back", System Of A Down "Hypnotize", Röövel Ööbik "Supersymmetry", Fort Minor "The Rising Tied", Korn "See You On The Other Side"

  11. 76 FR 82296 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2011-12-30

    ... Treatments and Prescribed Burning to Reduce Mountain Pine Beetle Risk and Fire Hazard, Hell Canyon Ranger... EIS, NOAA, AK, Effects of Oil and Gas Activities in the Arctic Ocean, Beaufort and Chukchi Seas, AK..., Fish, Soil, and Water Resources and Restoration of 2010 Forest Plan Vegetation Conditions, Emmett...

  12. Esitletakse Eesti ja Soome keeleteadlaste ühisraamatuid

    Index Scriptorium Estoniae

    2006-01-01

    Täna esitletakse Tallinna Ülikoolis Krista Kerge ja Maria-Maren Sepperi toimetatud raamatut "Finest Linguistics : proceedings of the annual Finnish and Estonian conference of linguistics : Tallinn, May 6-7, 2004" ning Helle Metslangi ja Siiri Soidro toimetatud teost "Lähivertailuja 16 : soome-eesti kontrastiivseminar 8.-9.05.2004"

  13. The in vitro biosynthesis of epitestosterone and testosterone from C19 steroid precursors in the testis of the lizard Tiliqua rugosa

    International Nuclear Information System (INIS)

    Huf, P.A.; Bourne, A.R.; Watson, T.G.

    1989-01-01

    The metabolism of androgens in the testis of the lizard Tiliqua rugosa has been studied in vitro by incubating cellular homogenates with radiolabeled C19-steroid substrates. The identification 17 beta-oxidoreductase and 3 beta-hydroxysteroid dehydrogenase/isomerase activities. Aromatase, 5 alpha-reductase, and 17 alpha/beta-epimerase activities were not detected. The 17 alpha-oxidoreductase activity was temperature dependent (maximal at 32 degrees), while the 17 beta-oxidoreductase activity was temperature independent. Time yield and dual-label studies indicated that testosterone biosynthesis mainly involves the 4-ene pathway (via androstenedione), whereas the formation of epitestosterone uses both the 4-ene and 5-ene (via 5-androstene-3 beta, 17 alpha-diol) pathways. The function of alternative pathways in androgen biosynthesis is discussed, as is the role of temperature in the intratesticular regulation of androgen production

  14. Transformations in the field of college education

    DEFF Research Database (Denmark)

    Bøje, Jakob Ditlev

    Paperet er kort version af den ene af mine analyser i ph.d.-projektet. Det drejer sig om en historisk diskursanalyse af transformationer af lærer- og pædagoguddnnnelse fra 60'erne til i dag.......Paperet er kort version af den ene af mine analyser i ph.d.-projektet. Det drejer sig om en historisk diskursanalyse af transformationer af lærer- og pædagoguddnnnelse fra 60'erne til i dag....

  15. Maternal influence on eggshell maculation: implications for cryptic camouflaged eggs

    Czech Academy of Sciences Publication Activity Database

    Duval, C.; Cassey, P.; Lovell, P.G.; Mikšík, Ivan; Reynolds, S.J.; Spencer, K.A.

    2016-01-01

    Roč. 157, č. 1 (2016), s. 303-310 ISSN 0021-8375 R&D Projects: GA ČR(CZ) GA15-01948S Institutional support: RVO:67985823 Keywords : body condition * camouflage * Coturnix coturnix japonica * eggs hell maculation * Protoporphyrin Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 1.468, year: 2016

  16. First light for avian embryos: eggshell thickness and pigmentation mediate variation in development and UV exposure in wild bird eggs

    Czech Academy of Sciences Publication Activity Database

    Maurer, G.; Portugal, S. J.; Hauber, M. E.; Mikšík, Ivan; Russell, D. G. D.; Cassey, P.

    2015-01-01

    Roč. 29, č. 2 (2015), s. 209-218 ISSN 0269-8463 R&D Projects: GA ČR(CZ) GA15-01948S Institutional support: RVO:67985823 Keywords : breeding birds * eggs hell colour * light transmission * nesting behaviour * pigments * ultraviolet light Subject RIV: ED - Physiology Impact factor: 5.210, year: 2015

  17. 76 FR 34690 - Placer County Water Agency; Notice of Application Accepted for Filing, Soliciting Motions To...

    Science.gov (United States)

    2011-06-14

    ... electronic filing, documents may also be paper-filed. To paper-file, mail an original and seven copies to... (project) has two principal water storage reservoirs, French Meadows and Hell Hole. These reservoirs are...-Middle Fork tunnel into French Meadows reservoir (134,993 ac-ft of gross storage). Flows in the Middle...

  18. Antiviral Mechanisms of the 2'-5' Oligoadenylate Synthetases

    DEFF Research Database (Denmark)

    Kristiansen, Helle

    During the course of her PhD studies, Helle Kristiansen carried out research into proteins that play a role in the defence against viral infection in humans and animals. All cells contain a considerable number of proteins that can directly or directly attack a virus and inhibit or completely stop...

  19. ”Hvad taler vi om, når vi taler om Bernhard?”

    DEFF Research Database (Denmark)

    Frantzen, Mikkel Krause; Nielsen, Claus Beck

    2013-01-01

    of depression, melancholia & mania, the state of walking versus the state of getting nowhere at high speed, not to mention the scandal of the toilets in Austrian restaurants. And it – of course – all ends in the deadly Bernhardian laughter and Austria as the only qualified heavenly hell on earth....

  20. Nime võimust : naine või artishokk / Leena Kurvet-Käosaar

    Index Scriptorium Estoniae

    Kurvet-Käosaar, Leena, 1969-

    2003-01-01

    Tagasivaade naisrežissööride filmifestivalile Helsingis. Lähemalt 4 mängufilmist : itaallanna Monica Stambrini "Benzina" (2001), inglanna Lynne Ramsay "Morvern Callar" (2002), prantslanna Sophie Tatscheffi "Baarilett" (1997) ja iraani päritolu rootsi režissööri Susan Taslimi "All Hell Let Loose" (2002)

  1. HELLE: Health Effects of Low Level Exposures

    International Nuclear Information System (INIS)

    Schoten, Eert

    1998-01-01

    The Health Council is closely involved in establishing the scientific foundation of exposure limits for substances and radiation in order to protect public health. Through the years, the Council has contributed to the formulation of principles and procedures, both for carcinogenic and for noncarcinogenic agents. As a rule, the discussion with regard to the derivation of health-based recommended exposure limits centers around the appropriateness of extrapolation methods (What can be inferred from data on high exposure levels and on experimental animals?). Generally speaking, there is a lack of direct information on the health effects of low levels of exposure. Effects at these levels cannot usually be detected by means of traditional animal experiments or epidemiological research. The capacity of these analytical instruments to distinguish between ''signal'' and ''noise'' is inadequate in most cases. Annex B of this report contains a brief outline of the difficulties and the established methods for tackling this problem. In spite of this, the hope exists that the posited weak signals, if they are indeed present, can be detected by other means. The search will have to take place on a deeper level. In other words, effort must be made to discover what occurs at underlying levels of biological organization when organisms are exposed to low doses of radiation or substances. Molecular and cell biology provide various methods and techniques which give an insight into the processes within the cell. This results in an increase in the knowledge about the molecular and cellular effects of exposure to agents, or stated differently, the working mechanisms which form the basis of the health effects. Last year, the Health Council considered that the time was ripe to take stock of the state of knowledge in this field. To this end, an international working conference was held from 19 to 21 October 1997, entitled ''Health Effects of Low Level Exposures: Scientific Developments and Perspectives for Risk Assessment''. The central question was the extent to which the sometimes fast-growing knowledge about molecular and cellular effects offers the desired basis for extrapolation. Against this setting, a number of more specific questions which have been hotly debated for some time were also addressed. One of the primary questions concerned the traditional but increasingly questioned division between stochastic and non-stochastic working agents, and the corresponding division between exposure-effect relations without a threshold and with a threshold. Thoughts were also exchanged on what is often referred to as hormesis: the notion that low levels of exposure could actually improve health. For the purpose of illuminating the many aspects of these issues, experts from a number of areas were invited. In addition to this, three agents were selected to serve as points of crystallization for the general debate: ionizing radiation, ultraviolet (UV) radiation and dioxins. The present report calls attention to a selection of issues which emerged during the discussions on the above-mentioned central topic. Various more detailed questions and the wider context of the points considered are described at greater length in the enclosed conference report and in the background documents attached to the report. What follows is a series of considerations regarding the scientific basis for the derivation of recommended exposure levels, viewed in the light of current procedures and against the background of the work of the Health Council. In the preparation of the following comments and recommendations, various Dutch experts have been consulted

  2. Hurricane Harvey & Houston: Hell or High Water

    Science.gov (United States)

    Bedient, P. B.

    2017-12-01

    Harvey was the largest rainfall and most damaging flood event in US history. By all measures the widespread impact was a devastating blow to all of Houston and surrounding areas. It dropped between 36 and 52 inches along the Texas coast over 5 days, exceeding all previous rainfall records, with up to 20 inches in a day. However, two earlier events from 2015 and 2016 also brought widespread flooding to many parts of Houston, especially concentrated in a few watersheds. Most bayous during Harvey were over bank by as much as 10 ft, and flooded an estimated 136000 homes in Harris county alone, greatly exceeding the massive TS Allison impact of 2001. While the area deals with a significant recovery effort, there is a massive call to action on the part of politicians, governmental agencies, and those affected by this event. There is need for a better statistical basis of rainfalls and floodplain mapping in Houston. Development patterns and density have come into question, as homes have been either built in 100 yr floodplains or taken into those floodplains over time. Estimates say > 47 % of homes flooded in TS Allison were outside the floodplain. Many homes were built behind Addicks/Barker reservoirs that protect downtown, many with no knowledge that they were in harms way (over 8000 were flooded there alone), and flooded as water reached record setting levels. New technologies have allowed the measurement and prediction of floods to make great strides since the mid 1990s, (Radar, LIDAR, GIS, hydrologic models, floodplain updates) and the Houston area has benefited from these efforts. While the plan going forward is daunting, there are a number of positive steps that are occurring and should lead to more resiliency. There needs to be policy changes on storage and detention requirements, green space & infrastructure improvements, and perhaps a third regional reservoir above Addicks. Also there is a renewed interest in flood warning systems to better inform the public about risk within specific watersheds. There is still a great deal of suffering out there after Harvey, but the three big floods we have just seen should cause a change in the way Houston addresses floodplains and develops into the future.

  3. 2006. aasta kalendrid / Moonika Teemus, Helle Remmelt

    Index Scriptorium Estoniae

    Teemus, Moonika

    2006-01-01

    TÜR-i kalendrist "Maalilised reisid : vaategraafikat TÜ Raamatukogu kogudes" ning RR-i kalendrist "Eesti aabitsad/Estonian ABC-books". Ka TLÜ AR kalendrist "Tallinn vanadel postkaartidel : kalender 2006"

  4. Project Lifespan-based Nonstationary Hydrologic Design Methods for Changing Environment

    Science.gov (United States)

    Xiong, L.

    2017-12-01

    Under changing environment, we must associate design floods with the design life period of projects to ensure the hydrologic design is really relevant to the operation of the hydrologic projects, because the design value for a given exceedance probability over the project life period would be significantly different from that over other time periods of the same length due to the nonstationarity of probability distributions. Several hydrologic design methods that take the design life period of projects into account have been proposed in recent years, i.e. the expected number of exceedances (ENE), design life level (DLL), equivalent reliability (ER), and average design life level (ADLL). Among the four methods to be compared, both the ENE and ER methods are return period-based methods, while DLL and ADLL are risk/reliability- based methods which estimate design values for given probability values of risk or reliability. However, the four methods can be unified together under a general framework through a relationship transforming the so-called representative reliability (RRE) into the return period, i.e. m=1/1(1-RRE), in which we compute the return period m using the representative reliability RRE.The results of nonstationary design quantiles and associated confidence intervals calculated by ENE, ER and ADLL were very similar, since ENE or ER was a special case or had a similar expression form with respect to ADLL. In particular, the design quantiles calculated by ENE and ADLL were the same when return period was equal to the length of the design life. In addition, DLL can yield similar design values if the relationship between DLL and ER/ADLL return periods is considered. Furthermore, ENE, ER and ADLL had good adaptability to either an increasing or decreasing situation, yielding not too large or too small design quantiles. This is important for applications of nonstationary hydrologic design methods in actual practice because of the concern of choosing the emerging

  5. Uloga radnog terapeuta u rehabilitaciji oboljelih od šizofrenije

    OpenAIRE

    Radić, Saša; Škrbina, Dijana

    2011-01-01

    Mentalno zdravlje je esencijalni čimbenik za aktivno i neovisno funkcioniranje u svim aspektima života. Poremećaji mentalnog zdravlja značajno narušavaju svakodnevno življenje, te uzrokuju disbalans u tri područja čovjekovih aktivnosti: samozbrinjavanju, produktivnosti i slobodnom vremenu. Odabir, organiziranje i aktivna participacija u produktivnim aktivnostima pojedinca narušenog mentalnoga zdravlja značajno su ograničene i/ili onemogućene zbog smanjene motivacije, nemogućnosti zadovo...

  6. POTENCIJALI PRIMJENE INTEGRIRANIH SUSTAVA UPRAVLJANJA U NAFTNOJ INDUSTRIJI

    OpenAIRE

    Lulić, Lukša

    2014-01-01

    S obzirom na svoje posebnosti, određene industrije i sektori moraju posjedovati specifične i rigorozne sustave upravljanja te su u skladu s takvim zahtjevima razvile industrijski specifične zahtjeve i standarde. Razlozi takvih aktivnosti uključuju upravljanje rizicima, spoznaju specifičnih zahtjeva određene industrije, sukladnost sa zakonskim i regulatornim zahtjevima te jačanje povjerenja u proizvode i procese dobavljača. Nafta je polivalentni energent, a naftna industrija podrazumijeva m...

  7. “Jan de Dood en sy bende”: Vergestaltings van die dood in die ...

    African Journals Online (AJOL)

    ... pale skin and either an emaciated woman in black, or a black woman as in Landskap met vroue en slang (Landscape with women and snake, 1996) Buller se plan and Niggie (translated as To Hell with Cronjé, 2002, 2007). These personifications function as so-called memento mori – iconographic reminders of mortality.

  8. Warfare 1914-2014: The most violent century in human history

    NARCIS (Netherlands)

    Klinkert, W.

    2016-01-01

    In the Spring of 1915 the French literary critic, journalist and theatre director Alphonse Séché (1876-1964) published a book on the Great War which was about six months old at the time. He called his extensive analysis Les guerres d’ enfer (Wars of Hell) and this unlikely expert displayed a

  9. Protection or proscription? Cultural practices against the background of religious pluralism

    NARCIS (Netherlands)

    Gaay Fortman, B. de

    2007-01-01

    Behind the substance of human rights are strong convictions that do not always convert into positive forces towards implementation. Calvin’s successor Theodore Beza, for example, saw freedom of religion as a very bad idea “because it means that everyone should be left to go to hell in his own way.”

  10. Euclid and his modern rivals

    CERN Document Server

    Carroll, Lewis

    2004-01-01

    The author of Alice in Wonderland (and an Oxford professor of mathematics) employs the fanciful format of a play set in Hell to take a hard look at late-19th-century interpretations of Euclidean geometry. Carroll's penetrating observations on geometry are accompanied by ample doses of his famous wit. 1885 edition.

  11. Hello...Hello...This Is the Poet Speaking...Do You Read Me...?

    Science.gov (United States)

    Gibbons, Maurice

    1972-01-01

    In dialogue between Poet" and English teacher", author writes, Kids will know a hell of a lot more about poetry if they read, experience, enjoy, talk, probe, criticize, respond and create...than if they line-by-line a few set poems." His thesis: the set poetry curriculum turns pupils off. (Author/PD)

  12. 77 FR 39694 - National Currents Energy Services, LLC; Notice of Declaration of Intention and Petition for...

    Science.gov (United States)

    2012-07-05

    ... Services, LLC. e. Name of Project: Wards Island Tidal Energy Project. f. Location: The proposed Wards Island Tidal Energy Project will be located off the south shore of Wards Island, in the Hell Gate... Manhattan, New York City, NY. g. Filed Pursuant to: 18 CFR part 24, section 24.1. h. Applicant Contact...

  13. Breakdown: Mind Terror in Sylvia Plath and Doris Lessing.

    Science.gov (United States)

    Ahearn, Marie

    Both Sylvia Plath and Doris Lessing use themes prevalent in Gothic horror tales--fear, madness, dissolution of personality, the dream journey, and the grotesque--but both writers make use of these themes in their own inimitable way. This paper discusses Plath's "The Bell Jar" and Lessing's "Briefing for a Descent into Hell" in…

  14. Pop / Tõnu Kaalep

    Index Scriptorium Estoniae

    Kaalep, Tõnu, 1966-2018

    2007-01-01

    Heliplaatidest: Tunnetusüksus "Ida ja Lääne vahel / Between East and West", Amy Winehouse "Back to Black", Kylie "Showgirl: Homecoming Live", Pet Shop Boys "Concrete", Gang Starr "Mass Appeal: The Best Of", Kling Klang "The Esthetik of Destruction", Clipse "Hell Hath NoFury", Tim Buckley "The Best of Tim Buckley"

  15. The Homeland Security Enterprise: Where Do We Fit?

    Science.gov (United States)

    2009-09-01

    derivative. ( Junod , 2009, p. 1) Seeing that a single incident influences the whole, how do we make sense of our individual place in the larger complex...Quotations, 10th ed. 1919e. [Walt Whitman] Retrieved April 27, 2009, from http://www.bartleby.com/100/503.34.html Junod , Tom (2009) What the hell

  16. Rasta-revolutsioon : ikka ja jälle. White label : Nikns Suns - Imed. Kuula / DJ Pickney Tiger

    Index Scriptorium Estoniae

    DJ Pickney Tiger, pseud., 1970-

    2007-01-01

    Heliplaadist "Bob Marley And The Wailers. Exodus". Ansamblist. Heliplaatidest: Taraf De Haidouks "Maskarada", Los Desterrados "Tu", Prince "Planet Earth", Manu Chao "La Radiolinia", Kanye West "Graduation", 50 Cent "Curtis", Vaiko Eplik ja Eliit 2", "Shahrukh. The King Khan. Vol 3", Big &Rich "Between Raising Hell and Amazing Graze", Tiit Kikas"String Theory"

  17. Pop / Andri Riid

    Index Scriptorium Estoniae

    Riid, Andri, 1972-

    2005-01-01

    Heliplaatidest: The Darkness "One Way Ticket to Hell... and Back", Peven Everett "Latest Craze (Part 1)", David Branner "Certified", Eminem "Curtain Call: The Hits", Horricane "The Lynch-Lawyers", Wilco "Kicking Television. Live in Chicago", The Mars Volta "Scab Dates", The Roots "Home Grown! The Beginners Guide To Understanding The Roots Volume 1-2"

  18. Kadriorust leiate pargiraamatukogu / Ene Tamsalu

    Index Scriptorium Estoniae

    Tamsalu, Ene

    2009-01-01

    2006. aastal avati Kadrioru Pargi raamatukogu, mille kogu aluseks on soome maastikuarhitektuuri professori Tuula Maria Merivuori pärandatud erialaraamatukogu, kus leiab kirjandust maastiku-, pargi- ja aiaarhitektuurist, linna- ja regionaalplaneerimisest, botaanikast ja aiandusest

  19. Riik arhitektuuritellijana / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2010-01-01

    Näidete varal Riigi Kinnisvara AS-i korraldatud projekteerimise hangetest, mil välja valiti odavaim pakkumine. Valminud Rakvere politseihoonest ning Jõgeva kohtu- ja politseihoonest. Mudelprojekteerimise (BIM) nõudest. Riigihankest kui salastatud protsessist. Sunnist loobuda autoriõigusest. Riigihankega ühendatud arhitektuurikonkursist

  20. Tohuvabohu kodukujunduses / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Tänapäeva Eesti kodukujundusest. Illustratsiooniks 90ndate kolm eramut : neomodernistlik Sinine Maja neominimalistliku interjööriga (Kolm Pluss Üks Arhitektid, arhitekt M. Kaasik), modernistlik villa Sumberg - (Urbel & Peil, arhitekt E. Urbel, sisekujundaja T. Mähar), ökosugemetega modernistlik villa Koger (arhitekt V. Sova, sisearhitektid A. Teigar, M. Press). Kommenteerivad Mart Kalm, Toivo Raidmets. Terminite selgitus.

  1. Armastus esimesest pilgust / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2005-01-01

    Annika Tederi jaapani stiilis aiast kui tähtsast osast eluruumis, mille kujundamisel on abiks olnud Liina Rehepapp. Jaapani aedadest, jaapanlaste suhtumisest aiakunsti ja lisaks artikkel "Eriilmelised ja -otstarbelised jaapani aiad"

  2. Messiuudised : Maison & Objet / Ene Jakobi

    Index Scriptorium Estoniae

    Jakobi, Ene

    2008-01-01

    Uusi trende kõige suuremalt disainimessilt Maison & Objet Prantsusmaal - Jean-Charles de Castelbajaci joonistatud toolid, Jean-Christophe Bernardi pleksiklaasist tool ja laud, Joseph Licciardi ja Paul Coheni-Philipp Veenendaali etanoolil põlevad kaminad, Philippe Lebru kellad, Vincenzo Antonuccio vaasid ja Anna Siedlecka ning Radek Achramoviczi täispuhutavad valgustid

  3. Maytenus distichophylla and Salacia crassifolia: source of products with potential acetylcholinesterase inhibition

    Directory of Open Access Journals (Sweden)

    Fernanda L. Ferreira

    Full Text Available ABSTRACT The phytochemical study of the extract leaves from Maytenus distichophylla Mart. and Salacia crassifolia (Mart. ex Schult. G. Don, Celastraceae, resulted in the isolation of 3-oxofriedelane, 3β-hydroxyfriedelane, 3β,24-dihydroxyfriedelane, 3-oxo-28,29-dihydroxyfriedelane, two mixtures of pentacyclic triterpenes (α-amyrin with β-amyrin and 3β-stearyloxy-urs-12-ene with 3β-stearyloxy-olean-12-ene, 3β-palmityloxy-urs-12-ene, the steroid β-sitosterol and its glycosylated derivative β-glucosyl-β-sitosterol, tritriacontanoic acid and the natural polymer gutta percha. The chemical structures of these constituents were established by IR, 1H and 13C NMR spectral data. Crude extracts, the mixtures of triterpenes and the isolated constituents were subjected to in vitro acetylcholinesterase inhibitory evaluation. Acetylcholinesterase inhibitory effect was observed for crude chloroform extract leaves from M. distichophylla (100% and S. crassifolia (97.93 ± 5.63% and for the triterpenes 3β,24-dihydroxyfriedelane (99.05 ± 1.12%, 3-oxo-28,29-dihydroxyfriedelane (90.59 ± 3.76% and 3β-palmityloxy-urs-12-ene (97.93 ± 1.47%. The percent inhibitions induced by these natural products were very similar to those produced by physostigmine (93.94 ± 2.10% a standard acetylcholinesterase inhibitor. Therefore, these results open perspectives for the use of these species as source of compounds with similar physostigmine pharmacological effect.

  4. Diffusion coefficient

    Indian Academy of Sciences (India)

    kbhattacharjee

    in bulk water becomes Au. 13 inside cell. Fluorescent Gold Nanocluster Inside a Human Breast Cell. Au. 25. Au. 13. Bulk water. Live cell. Emission energy = E f. / N1/3. Cancer. N = number of Au atoms in cluster ..... <λ/2. Super Resolution Microscopy: < λ/2. STED = Stimulated Emission Depletion (S. HELL). Strategy: two ...

  5. Olla originaalne ja tähelepandud / Eve Sepp

    Index Scriptorium Estoniae

    Sepp, Eve

    1989-01-01

    Tuntud daamide originaalehetest - tekstiilikunstnik Anna Gerretzi Ülle Kõutsi valmistatud kõrvarõngad, disainer Helle Gansi Katrin Amose loodud rinnanõel, raamatukogudirektrissi Anne Randeli Tiina Käeseli loodud ehted, arhitekt Marka Lõokese Kadri Mälgu loodud komplekt, kunstiteadlase Krista Kodrese Tiina Käeseli loodud komplekt, grimeerija Krista Pärdi abikaasa Rein Metsa loodud ehted

  6. Compensating Scientism through "The Black Hole."

    Science.gov (United States)

    Roth, Lane

    The focal image of the film "The Black Hole" functions as a visual metaphor for the sacred, order, unity, and eternal time. The black hole is a symbol that unites the antinomic pairs of conscious/unconscious, water/fire, immersion/emersion, death/rebirth, and hell/heaven. The black hole is further associated with the quest for…

  7. Kümme aastat R-klubi / Maria-Maren Sepper

    Index Scriptorium Estoniae

    Sepper, Maria-Maren

    2014-01-01

    R-klubi (aeg-ajalt Tallinnas kogunev klubi, mis pakub tagasisidet eesti keele alases uurimistöös, ennekõike väitekirjauurimuste tegemisel ja artiklite publitseerimisel) 10. aastapäeva puhul peetud seminarist Tallinna Ülikoolis 21.3.2014. R-klubi sai alguse Helle Metslangi juhendatavate TLÜ kraadiõppurite tööde ühisaruteludest

  8. Najib Mahfuz on Power, Status and Authority in Africa's Public Sphere

    African Journals Online (AJOL)

    chifaou.amzat

    2010-04-14

    Apr 14, 2010 ... Outside the Great House, life becomes a hell for Adham and his wife. ... people in the quarter believe is responsible for the death of the former. ... might be found to be true at least going by the structure of Muslim cities in ...... Mahfouz, Sonallah Ibrahim and Gamal al-Ghitani, Cairo: American University.

  9. Postcolonial Myth in Salman Rushdie’s The Ground Beneath Her Feet

    Directory of Open Access Journals (Sweden)

    Doncu Roxana Elena

    2014-01-01

    Full Text Available Postcolonial writers like Salman Rushdie often write back to the “empire” by appropriating myth and allegory. In The Ground beneath Her Feet, Rushdie rewrites the mythological story of Orpheus and Eurydice, using katabasis (the trope of the descent into Hell to comment both on the situation of the postcolonial writer from a personal perspective and to attempt a redefinition of postcolonial migrant identity-formation. Hell has a symbolic function, pointing both to the external context of globalization and migration (which results in the characters’ disorientation and to an interior space which can be interpreted either as a source of unrepressed energies and creativity (in a Romantic vein or as the space of the abject (in the manner of Julia Kristeva. The article sets out to investigate the complex ways in which the Orphic myth and katabasis are employed to shed light on the psychology of the creative artist and on the reconfiguration of identity that becomes the task of the postcolonial migrant subject. The journey into the underworld functions simultaneously as an allegory of artistic creation and identity reconstruction.

  10. Pulsar timing arrays and gravity tests in the radiative regime

    Science.gov (United States)

    Lee, K. J.

    2013-11-01

    In this paper, we focus on testing gravity theories in the radiative regime using pulsar timing array observations. After reviewing current techniques to measure the dispersion and alternative polarization of gravitational waves, we extend the framework to the most general situations, where the combinations of a massive graviton and alternative polarization modes are considered. The atlas of the Hellings-Downs functions is completed by the new calculations for these dispersive alternative polarization modes. We find that each mode and corresponding graviton mass introduce characteristic features in the Hellings-Downs function. Thus, in principal, we can not only detect each polarization mode, measure the corresponding graviton mass, but also discriminate the different scenarios. In this way, we can test gravity theories in the radiative regime in a generalized fashion, and such method is a direct experiment, where one can address the gauge symmetry of the gravity theories in their linearized limits. Although current pulsar timing still lacks enough stable pulsars and sensitivity for such practices, we expect that future telescopes with larger collecting areas could make such experiments feasible.

  11. Today’s Mumbai as Photo-Textuality

    Directory of Open Access Journals (Sweden)

    Carmen Concilio

    2015-06-01

    Full Text Available The aim of this essay is to enquire into representations of the city of Mumbai whose urban development has produced images of heaven and hell, sometimes within enclosed boundaries. What is interesting to tackle here is its aestheticisation in a photo-book which presents itself as ‘image-text’ (Mitchel, Stafford, Bombay/Mumbai. Immersions (2013. Not differently from what happens in other cities, such as Cape Town, for instance, here considered only very briefly as counterpoint, the Indian megalopolis’s development has produced disconnected images of urban heaven and hell. The photo-text here discussed presents itself as a composite narrative of words and photos, as the product of the cooperation between an Indian woman poet, Priya Sarukkai Chabria, and an English photographer now based in France, Christopher Taylor. Last but certainly not least in a long sequence of urban photo-texts, this new project requires the reader’s attention in order to try and clarify its role, its meaning, its function, its ethical/aesthetic responsibilities.

  12. Estudo fitoquímico da madeira de Guarea macrophylla (Meliaceae Phytochemical study of the wood from Guarea macrophylla (Meliaceae

    Directory of Open Access Journals (Sweden)

    João Henrique G. Lago

    2009-01-01

    Full Text Available In the present work, the crude ethanol extract from wood of G. macrophylla was submitted to liquid/liquid partition between hexane, CH2Cl2, EtOAc and n-BuOH. Each phase was individually chromatographed over silica gel, Sephadex LH-20 or Amberlite XAD-2 to give eight terpene derivatives, such as five sesquiterpenoids (caryophyllene oxide, guai-6-en-10β-ol, spathulenol, aromadendrane-4β,10α-diol and aloaromadendrane-4α,10β-diol as well as three triterpenoids (cicloart-24-ene-3β,23(R*-diol, cicloart-24-ene-3β,23(S*-diol, and cicloart-23E-ene-3β,25-diol. Additionally, were isolated three fatty acids (linolenic, linoleic and stearic, two steroids (sitosterol and stigmasterol and sacarose. The structures of all these compounds were characterized by spectrometric analysis, mainly mass spectrometry and NMR and comparison of these data described in the literature.

  13. Stordrift af sundhedsteknologi kræver ny organisering

    DEFF Research Database (Denmark)

    Wentzer, Helle

    2013-01-01

    Når det gælder telemedicin, er det ikke alle patienter, der kan tilbydes den samme tekniske løsning. Det stiller nogle helt særlige krav, når man vil indføre sundhedsteknologiske løsninger i stor skala, skriver senior projektleder Helle Wentzer fra KORA i dette debatindlæg....

  14. Politisk Kronik 1.halvår 2014

    DEFF Research Database (Denmark)

    Bille, Lars

    2016-01-01

    I sin nytårstale anslog statsminister Helle Thorning-Schmidt en moderat optimistisk tone. Godt nok var krisen ikke ovre, men stemningen var ved at vende, og der var grund til at tro på fremgang i 2014. Danmark var et solidarisk land, og det skulle det vedblive med at være. Derfor ville regeringen...

  15. Subatomic inferno under the Alps

    CERN Multimedia

    Borland, John

    2006-01-01

    "Sky is the Swiss-French border, pastoral Geneva countryside in the shadow of soaring alpine mountains. Hell is "The machine" - a 16.8-mile underground ring where, in almost precisely a year, superconducting magnets will begin accelerating atomic particles to within a hairsbreadth of the speed of light, and smash them into each other." (2 pages)

  16. Resonance – Journal of Science Education | News

    Indian Academy of Sciences (India)

    Akshay Kulkarni P Ramadevi · More Details Fulltext PDF. pp 42-55 General Article. Infinite Descent – but not into Hell! Shailesh A Shirali · More Details Fulltext PDF. pp 56-64 General Article. Flight Research using Radio-controlled Small Airplanes · S P Govinda Raju · More Details Fulltext PDF. pp 65-75 General Article.

  17. Moving Clocks Do Not Always Appear to Slow down: Don't Neglect the Doppler Effect

    Science.gov (United States)

    Wang, Frank

    2013-01-01

    In popular accounts of the time dilation effect in Einstein's special relativity, one often encounters the statement that moving clocks run slow. For instance, in the acclaimed PBS program "NOVA," Professor Brian Greene says, "[I]f I walk toward that guy... he'll perceive my watch ticking slower." Also in his earlier piece for The New York Times,…

  18. "Kuldne kolmnurk" ja "punapõsine kornet" / Kaire Nurk

    Index Scriptorium Estoniae

    Nurk, Kaire, 1960-

    2000-01-01

    Tartu kunst XX sajandil: sajandi alguse pildina Kristjan Raua tööst "Puhkus rännakul", kokkuvõttena sajandile Ado Vabbe preemia saanud kunstnikest ئ Peeter Allik, Lola Liivat, Helle Vahersalu ئ ja nende loomingust. Sõjajärgse Tartu kunsti jõudmisest Tallinna ning selle kajastamisest S. Helme, J. Kangilaski "Lühikeses eesti kunsti ajaloos".

  19. Against the Intentional Fallacy: Legocentrism and Continuity in the Rhetoric of Indian Dispossession

    Science.gov (United States)

    Wolfe, Patrick

    2012-01-01

    The road of US Indian law and policy, like its companion to hell, is paved with good intentions. Critics of its generally diabolic outcomes have had little difficulty demonstrating the moral chasm between the appealing rhetoric in which a policy or judgment was framed and the oppressive consequences to which it practically conduced. With a nod to…

  20. Farestrategier og trampolinleg

    DEFF Research Database (Denmark)

    Karoff, Helle Skovbjerg

    Vild og farlig leg på havetrampoliner udfordrer børns sikkerhed og tryghed og er samtidig både udviklende og udfordrende. Børn kan lære at håndtere risici, når de leger på trampolinen. Helle Skovbjerg Karoff er adjunkt ved Aalborg Universitet/København og knyttet til forskningslaboratoriet for IT...

  1. EEG POLISOMNOGRAFIJA KAO ZNAČAJNA DIJAGNOSTIČKA I PROGNOSTIČKA METODA ZA PROCJENU OŠTEĆENJA MOZGA U NOVOROĐENČADI I DOJENČADI

    OpenAIRE

    Paškov Dugandžija, Gordana

    2008-01-01

    EEG polisomnografija je značajna metoda za dijagnozu i prognozu oštećenja mozga u nedonošene i donošene novorođenčadi i dojenčadi. Sadrži slijedeće elemente: EEG(elektroencefalografija), EOG( elektrookulografija) , EMG( elektromiografija), EKG (elektrokardiografija), respiracija i video monitoriranje. Primjenjujemo polisomnografsku montažu. To je specifično modificiran način postavljanja elektroda. Koristimo posrebrene pločaste elektrode sa 1 metar savitljivim silikonskim odvodima u šest razl...

  2. Teatri aastaauhindade nominendid

    Index Scriptorium Estoniae

    2006-01-01

    Lavastajaauhind : Merle Karusoo, Elmo Nüganen, Tiit Ojasoo, Ene-Liis Semper, Kristian Smeds, Hendrik Toompere jun, Ingomar Vihmar ; kunstnikuauhind : Iir Hermeliin, Liina Keevallik, Ene-Liis Semper, Aime Unt, Ervin Õunapuu ; naisnäitleja auhind : Ülle Kaljuste, Kaie Mihkelson, Harriet Toompere, Marika Vaarik, Liina Vahtrik ; meesnäitleja auhind : Ain Lutsepp, Rein Oja, Rain Simmul, Tarvo Sõmer, Tambet Tuisk, Aarne Üksküla ; Balleti- ja tantsuteater : Marina Tshirkova, Seki Hirotaka, Mari Savitski, Oksana Titova, Taavet Jansen, Sasha Pepeljajev, Katrin Essenson ja Tantsuteater Fine 5

  3. Teatri aastaauhindadele kandideerijad selgunud

    Index Scriptorium Estoniae

    2006-01-01

    Lavastajaauhind : Merle Karusoo, Elmo Nüganen, Tiit Ojasoo, Ene-Liis Semper, Kristian Smeds, Hendrik Toompere jun, Ingomar Vihmar ; kunstnikuauhind : Iir Hermeliin, Liina Keevallik, Ene-Liis Semper, Aime Unt, Ervin Õunapuu ; naisnäitleja auhind : Ülle Kaljuste, Kaie Mihkelson, Harriet Toompere, Marika Vaarik, Liina Vahtrik ; meesnäitleja auhind : Ain Lutsepp, Rein Oja, Rain Simmul, Tarvo Sõmer, Tambet Tuisk, Aarne Üksküla ; Balleti- ja tantsuteater : Marina Tshirkova, Seki Hirotaka, Mari Savitski, Oksana Titova, Taavet Jansen, Sasha Pepeljajev, Katrin Essenson ja Tantsuteater Fine 5

  4. Profil Pasien HIV di Klinik VCT Sehati RSUD Dr. T.C. Hillers Maumere Tahun 2014

    Directory of Open Access Journals (Sweden)

    Lidwina Anissa

    2015-12-01

    Full Text Available Infeksi HIV merupakan masalah kesehatan dunia. Terdapat peningkatan jumlah infeksi baru di Indonesia. Penelitian ini bertujuan untuk mengetahui profil  pasien HIV di area rural. Studi ini merupakan studi potong lintang dengan data register pasien dalam periode Januari – Desember 2014. HIV di Klinik VCT Sehati RSUD Dr.TC Hillers Maumere, Kabupaten Sikka. Terdapat 104 pasien  yang terdiagnosis HIV positif, 64,4% di antaranya adalah laki-laki. Tingkat pendidikan terbanyak adalah tingkat pendidikan menengah (46,2% dan rendah (44,2%. Rute transmisi terbanyak adalah hubungan seksual heteroseksual (74%. Gejala terbanyak yang dikeluhkan pasien adalah batuk lama, penurunan berat badan dan demam naik turun. Infeksi oportunistik terbanyak adalah TB paru dan kandidosis oral. Infeksi HIV membutuhkan penangan secara holistik yang menjamin kualitas hidup pasien baik dari aspek fisik dan psikis. Edukasi kesehatan reproduksi terutama HIV dan infeksi menular seksual lainnya memegang peranan penting dalam rangka upaya meningkatkan wawasan mengenai HIV sekaligus sebagai upaya pencegahan infeksi baru dan pemutusan rantai penularan. Dukungan peer group memiliki peranan penting dalam peningkatan kualitas hidup pasien. Kata kunci: HIV, heteroseksual, homoseksual, infeksi oportunistik, rute transmisi.   HIV Patients’ Profile in Sehati VCT Clinic Dr.T.C. Hillers Maumere in 2014 Abstract HIV infection is one of global health problems. The number of new infection is increasing in Indonesia. This research aims to study the profile of HIV patients in rural area. This reasearch is a cross-sectional study on patients registers in Sehati Voluntary Counseling Testing / HIV care unit in Dr.TC Hillers District General Hospital, Sikka Regency during January untill December 2014 period. There were 104 subjects diagnosed as HIV positive and 64.4% of them were male. The most common education level was middle school (46.2% and elementary school (44.2%. The most frequent

  5. On rates and mechanisms of OH and O3 reactions with isoprene-derived hydroxy nitrates.

    Science.gov (United States)

    Lee, Lance; Teng, Alex P; Wennberg, Paul O; Crounse, John D; Cohen, Ronald C

    2014-03-06

    Eight distinct hydroxy nitrates are stable products of the first step in the atmospheric oxidation of isoprene by OH. The subsequent chemical fate of these molecules affects global and regional production of ozone and aerosol as well as the location of nitrogen deposition. We synthesized and purified 3 of the 8 isoprene hydroxy nitrate isomers: (E/Z)-2-methyl-4-nitrooxybut-2-ene-1-ol and 3-methyl-2-nitrooxybut-3-ene-1-ol. Oxidation of these molecules by OH and ozone was studied using both chemical ionization mass spectrometry and thermo-dissociation laser induced fluorescence. The OH reaction rate constants at 300 K measured relative to propene at 745 Torr are (1.1 ± 0.2) × 10(-10) cm(3) molecule(-1) s(-1) for both the E and Z isomers and (4.2 ± 0.7) × 10(-11) cm(3) molecule(-1) s(-1) for the third isomer. The ozone reaction rate constants for (E/Z)-2-methyl-4-nitrooxybut-2-ene-1-ol are (2.7 ± 0.5) × 10(-17) and (2.9 ± 0.5) × 10(-17) cm(3) molecule(-1) s(-1), respectively. 3-Methyl-2-nitrooxybut-3-ene-1-ol reacts with ozone very slowly, within the range of (2.5-5) × 10(-19) cm(3) molecule(-1) s(-1). Reaction pathways, product yields, and implications for atmospheric chemistry are discussed. A condensed mechanism suitable for use in atmospheric chemistry models is presented.

  6. Olefins transformation catalysis by zirconium and tungsten complexes in organic and non-aqueous ionic media; Catalyse de transformation des olefines par les complexes du zirconium et du tungstene en milieux organique et ionique non aqueux

    Energy Technology Data Exchange (ETDEWEB)

    Laurent-Gerot, P

    1997-06-30

    Molten salts are suitable solvents for biphasic catalysis: melting butyl-1 methyl-3 imidazolium chloride and aluminium chloride gives a polar and aprotic ionic liquid which is not miscible with hydrocarbons but dissolves organometallic complexes. Two types of complexes have been tested in molten salts with ethyl-aluminium dichloride: zirconium complexes to synthesize light {alpha} olefins from ethene; mono-imido complexes of tungsten VI (Cl{sub 4}W = NAr) to dimerize ethene in but-1 ene and propene in dimethyl-2,3-but-1-ene. For both of these complexes, biphasic catalysis principle is always respected: the active species is present only in the ionic phase and not in the organic phase. The first complexes, biphasic principle is always respected: the active species is present only in the ionic phase and not in the organic phase. The first complexes oligomerize ethene in molten salts with low activity and the {alpha} olefins selectivity is weak. Mono-imido complexes of tungsten VI are proved to be equivalent to the systems composed with WCl{sub 6} and aniline, and they dimerize ethene in but-1 ene and propene in dimethyl-2,3-but-1 ene more efficiently in organic medium than in ionic liquid. The characterization of the active species of the system Cl{sub 4}W=NAr / EtAlCl{sub 2} shows that it is the corresponding mono-imido complex of tungsten 4. (author) 129 refs.

  7. Agripinin portret u odnosu prema rimskim ženskim portretima s pulskog i nezakcijskog agera

    OpenAIRE

    Girardi Jurkić, Vesna; Džin, Kristina

    2006-01-01

    Za vrijeme zaštitnog arheološkog istraživanja (1987.-1988.) na forumu u Puli (Colonia Pola)otkrivena je mramorna ženska glava za koju se pretpostavlja da je portret Agripine Mlađe, ženecara Klaudija i majke cara Nerona. Skulptura je originalno vjerojatno bila postavljena na zidanojbazi u sjeveroistočnom zidu luksuzne prostorije popločene mramorom i ukrašene štukaturama nazidu kojega je baza bila ukrašena mramorom i štukom. Tri natpisa otkrivena u blizini tzv. Agripininekuće spominju careve Kl...

  8. Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells.

    OpenAIRE

    Pegg, A E; Nagarajan, S; Naficy, S; Ganem, B

    1991-01-01

    Synthetic unsaturated analogues of the natural polyamine were examined as possible substrates for spermine synthase and as replacements for spermidine in supporting the growth of SV-3T3 cells. It was found that N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene [the cis isomer of the alkene analogue of spermidine] was a good substrate for spermine synthase, but that the trans isomer [N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene] and the alkene analogue [N-(3-aminopropyl)-1,4-diaminobut-2-yne] were ...

  9. Thermal rearrangement of 7-methylbicyclo

    Science.gov (United States)

    Bender; Leber; Lirio; Smith

    2000-08-25

    The gas-phase thermal rearrangement of exo-7-methylbicyclo[3.2.0]hept-2-ene yields almost exclusively 5-methylnorbornene products. Inversion (i) of configuration dominates this [1,3] sigmatropic shift although some retention (r) is also observed. Because the [1,3] migration can only occur suprafacially (s) in this geometrically constrained system, the si/sr ratio of 7 observed for the migration of C7 in exo-7-methylbicyclo[3.2.0]hept-2-ene indicates that the orbital symmetry rules are somewhat permissive for the [1,3] sigmatropic migration of carbon.

  10. Antiproliferative Compounds of Cyphostemma greveana from a Madagascar Dry Forest[1

    OpenAIRE

    Cao, Shugeng; Hou, Yanpeng; Brodie, Peggy; Miller, James S.; Randrianaivo, Richard; Rakotobe, Etienne; Rasamison, Vincent E.; Kingston, David G. I.

    2011-01-01

    Bioassay-guided fractionation of the EtOH extracts obtained from a plant identified as Cyphostemma greveana Desc. (Vitaceae) led to the identification of one macrolide, lasiodiplodin (1), three sesquiterpenoids, 12-hydroxy-15-oxo-selina-4,1l-diene (2), 1β,6α-dihydroxyeudesm-4(15)-ene (3), and (7R*)-opposit-4(15)-ene-1β,7-diol (5), and the new diterpenoid, 16,18-dihydroxykolavenic acid lactone (4). All the isolates were tested against the A2780 human ovarian cancer cell line, and compound 4 an...

  11. Terpenoid constituents from leaves of Guarea kunthiana

    International Nuclear Information System (INIS)

    Garcez, Fernanda R.; Garcez, Walmir S.; Bazzo, Rita de Cassia; Silva, Ana Francisca G. da; Resende, Ubirazilda M.

    2004-01-01

    From leaves of Guarea kunthiana one new kaurene diterpene (ent-kaur-16-en-2-one) was isolated along with eight known diterpenes (ent-kaur-16-ene, ent-3α- and 3β-hydroxykaur-16-ene, kolavelool, kolavenol, kolavenal, ent-13-epi-manoyloxide and (-)-nephthenol), four sesquiterpenes (alismol, alismoxide, spathulenol and 4β,10α-aromadendranediol), polyprenol-12 and α- and δ-tocopherols. Kolavenal is reported for the first time as a natural product, as well as the occurrence of cembrane- and ent-kaurane-type diterpenes in the Meliaceae. (author)

  12. O social entre o céu e o inferno: a antropologia filosófica de Pierre Bourdieu The social between heaven and hell: Pierre Bourdieu's philosophical anthropology

    Directory of Open Access Journals (Sweden)

    Gabriel Peters

    2012-01-01

    , attempted to make explicit that his historical-sociological investigations were founded upon, and the same time contributed to elaborate, an 'idea of "Man"'. The article retraces Bourdieu's path towards this philosophical anthropology, starting with his genetic sociology of symbolic power, conceived as a form of critical theory (latu sensu, and concluding with an account of the human condition in which recognition ("symbolic capital" appears as both the fundamental existential goal through which individuals attempt to obtain meaning to their lives and the source of the endless symbolic competition that keeps social life moving. The agonistic vision of the social universe that grounds his sociological studies returns in his philosophical anthropology under the guise of a singular synthesis between Durkheim's idea that 'Society is God' and Sartre's thesis that 'hell is other people'.

  13. Effects of Hyporheic Exchange Flows on Egg Pocket Water Temperature in Snake River Fall Chinook Salmon Spawning Areas

    Energy Technology Data Exchange (ETDEWEB)

    Hanrahan, Timothy P.; Geist, David R.; Arntzen, Evan V.; Abernethy, Cary S.

    2004-09-24

    The development of the Snake River hydroelectric system has affected fall chinook salmon smolts by shifting their migration timing to a period when downstream reservoir conditions are unfavorable for survival. Subsequent to the Snake River chinook salmon fall-run Evolutionary Significant Unit being listed as Threatened under the Endangered Species Act, recovery planning has included changes in hydrosystem operations to improve water temperature and flow conditions during the juvenile chinook salmon summer migration period. In light of the limited water supplies from the Dworshak reservoir for summer flow augmentation, and the associated uncertainties regarding benefits to migrating fall chinook salmon smolts, additional approaches for improved smolt survival need to be evaluated. This report describes research conducted by PNNL that evaluated relationships among river discharge, hyporheic zone characteristics, and egg pocket water temperature in Snake River fall chinook salmon spawning areas. The potential for improved survival would be gained by increasing the rate at which early life history events proceed (i.e., incubation and emergence), thereby allowing smolts to migrate through downstream reservoirs during early- to mid-summer when river conditions are more favorable for survival. PNNL implemented this research project throughout 160 km of the Hells Canyon Reach (HCR) of the Snake River. The hydrologic regime during the 2002?2003 sampling period exhibited one of the lowest, most stable daily discharge patterns of any of the previous 12 water years. The vertical hydraulic gradients (VHG) between the river and the riverbed suggested the potential for predominantly small magnitude vertical exchange. The VHG also showed little relationship to changes in river discharge at most sites. Despite the relatively small vertical hydraulic gradients at most sites, the results from the numerical modeling of riverbed pore water velocity and hyporheic zone temperatures

  14. Noninvasive Spatially Offset and Transmission Raman Mapping of Breast Tissue: A Multimodal Approach Towards the In Vivo Assessment of Tissue Pathology

    Science.gov (United States)

    2013-06-01

    16. Hell, S.; Reiner, G.; Cremer , C.; Stelzer, E.H.K. Aberrations in confocal fluorescence microscopy induced by mismatches in refractive index. J...jp402392y Paper 6: Mayerich, David ; Walsh, Michael; Schulmerich, Matthew; Bhargava, Rohit; Real-time interactive data mining for chemical imaging...RESEARCH ARTICLE Open Access Real-time interactive data mining for chemical imaging information: application to automated histopathology David

  15. "Arising from Sullen Earth": The 52nd Street Project's Transformative Teen Shakespeare Project

    Science.gov (United States)

    Sandberg-Zakian, Megan

    2010-01-01

    The author of this document spent time as the Associate Artistic Director of The 52nd Street Project, a not-for-profit theater company dedicated to the creation and production of new plays for, and often by, kids between the ages of nine and eighteen that reside in the Hell's Kitchen neighborhood of New York City. Through a series of unique…

  16. Infabric - "Dive into the fabric of opinion"

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    "Why should I trust this article and not that one? Why the hell do you think something sooo stupid!?" I want to build an interactive online publishing platform promoting fact-based structured argumentation designed to act as an antidote for problems of the post-truth society. I'm looking for people who would like to help me to create a prototype right now.

  17. Outlook: The Next Twenty Years

    Energy Technology Data Exchange (ETDEWEB)

    Murayama, Hitoshi

    2003-12-07

    I present an outlook for the next twenty years in particle physics. I start with the big questions in our field, broken down into four categories: horizontal, vertical, heaven, and hell. Then I discuss how we attack the bigquestions in each category during the next twenty years. I argue for a synergy between many different approaches taken in our field.

  18. Hydrolysis of strained bridgehead bicyclic vinyl ethers and sulfides

    International Nuclear Information System (INIS)

    Chwang, W.K.; Kresge, A.J.; Wiseman, J.R.

    1979-01-01

    Rates of hydrolysis of the bridgehead bicyclic vinyl ether 9-oxabicyclo[3.3.1]non-1-ene(6) and its vinyl sulfide counterpart 9-thiabicyclo[3.3.1]non-1-ene(7), catalyzed by the hydronium ion, were measured in H 2 O and in D 2 O solution. These data give isotope effects, k/sub H//k/sub D/ = 2.4 and 1.9 respectively, which show that these reactions occur by the normal, rate-determining carbon protonation, mechanism. The vinyl ether 6 is less reactive than its olefin analogue, bicyclo[3.3.1]non-1-ene (relative rate 1:1/1400), as may have been expected for a constrained bicyclic system such as this, where stabilization of the bridgehead carbocation intermediate by conjugation with oxygen is severely impaired. The vinyl sulfide 7, however, is even less reactive than the vinyl ether (relative rates 1:1/140); this is a remarkable result in view of the fact that conjugation between the sulfur atom and the cationic center is presumably also strongly inhibited. 1 figure, 3 tables

  19. Hollow Nanospheres Array Fabrication via Nano-Conglutination Technology.

    Science.gov (United States)

    Zhang, Man; Deng, Qiling; Xia, Liangping; Shi, Lifang; Cao, Axiu; Pang, Hui; Hu, Song

    2015-09-01

    Hollow nanospheres array is a special nanostructure with great applications in photonics, electronics and biochemistry. The nanofabrication technique with high resolution is crucial to nanosciences and nano-technology. This paper presents a novel nonconventional nano-conglutination technology combining polystyrenes spheres (PSs) self-assembly, conglutination and a lift-off process to fabricate the hollow nanospheres array with nanoholes. A self-assembly monolayer of PSs was stuck off from the quartz wafer by the thiol-ene adhesive material, and then the PSs was removed via a lift-off process and the hollow nanospheres embedded into the thiol-ene substrate was obtained. Thiolene polymer is a UV-curable material via "click chemistry" reaction at ambient conditions without the oxygen inhibition, which has excellent chemical and physical properties to be attractive as the adhesive material in nano-conglutination technology. Using the technique, a hollow nanospheres array with the nanoholes at the diameter of 200 nm embedded into the rigid thiol-ene substrate was fabricated, which has great potential to serve as a reaction container, catalyst and surface enhanced Raman scattering substrate.

  20. Effects of Hyporheic Exchange Flows on Egg Pocket Water Temperature in Snake River Fall Chinook Salmon Spawning Areas, 2002-2003 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Hanrahan, T.; Geist, D.; Arntzen, C. (Pacific Northwest National Laboratory)

    2004-09-01

    The development of the Snake River hydroelectric system has affected fall Chinook salmon smolts by shifting their migration timing to a period (mid- to late-summer) when downstream reservoir conditions are unfavorable for survival. Subsequent to the Snake River Chinook salmon fall-run Evolutionary Significant Unit being listed as Threatened under the Endangered Species Act, recovery planning has included changes in hydrosystem operations (e.g., summer flow augmentation) to improve water temperature and flow conditions during the juvenile Chinook salmon summer migration period. In light of the limited water supplies from the Dworshak reservoir for summer flow augmentation, and the associated uncertainties regarding benefits to migrating fall Chinook salmon smolts, additional approaches for improved smolt survival need to be evaluated. This report describes research conducted by the Pacific Northwest National Laboratory (PNNL) that evaluated relationships among river discharge, hyporheic zone characteristics, and egg pocket water temperature in Snake River fall Chinook salmon spawning areas. This was a pilot-scale study to evaluate these relationships under existing operations of Hells Canyon Dam (i.e., without any prescribed manipulations of river discharge) during the 2002-2003 water year. The project was initiated in the context of examining the potential for improving juvenile Snake River fall Chinook salmon survival by modifying the discharge operations of Hells Canyon Dam. The potential for improved survival would be gained by increasing the rate at which early life history events proceed (i.e., incubation and emergence), thereby allowing smolts to migrate through downstream reservoirs during early- to mid-summer when river conditions are more favorable for survival. PNNL implemented this research project at index sites throughout 160 km of the Hells Canyon Reach (HCR) of the Snake River. The HCR extends from Hells Canyon Dam (river kilometer [rkm] 399

  1. Õppima õppimine ja õppimisoskus / Helle-Mall Kadajas

    Index Scriptorium Estoniae

    Kadajas, Helle-Mall, 1943-

    2000-01-01

    Õppima õppimise seos õppimisoskusega, õppimisoskuse kujundamine. Tallinna Pedagoogikaülikooli õpetajakoolituse üliõpilaste seas läbi viidud uuringust, millega selgitati nende enesehinnangut õppimisoskusele, mida nad õpetajana õppima õpetamisel oluliseks peavad, nende edukust õppimisel

  2. Teaching Human Rights? "All Hell Will Break Loose!"

    Science.gov (United States)

    Cassidy, Claire; Brunner, Richard; Webster, Elaine

    2014-01-01

    Human rights education is a prominent concern of a number of international organisations and has been dominant on the United Nations' agenda for the past 20 years. The UN Decade for Human Rights Education (1995-2004) has been followed by the World Programme for Human Rights Education (2005-ongoing) and the recently adopted UN Declaration on Human…

  3. School Is Hell: Gendered Fears in Teenage Horror.

    Science.gov (United States)

    Jarvis, Christine

    2001-01-01

    Explores the use of schools as settings for teenage horror films. Asserts that these narratives reflect the stress of social pressures and uncertainties, particularly young girls. Focuses on the television show, "Buffy the Vampire Slayer," while making this argument. Includes references. (CMK)

  4. Lauluga läbi Ameerika 4 / Helle Reinaru

    Index Scriptorium Estoniae

    Reinaru, Helle, 1955-

    2006-01-01

    EELK Misjonikoori kontsertturneest 5.-25. juulini Ameerika Ühendriikides ja Kanadas: jumalateenistusest 16. juulil Missoula St Paul'i luteri kirikus, kontserdist 17. juulil Calvary luteri kirikus, 18. juulil Seattle's Phinney Ridge kirikus, 20. juulil Kanada Scarborough St Timothy anglikaani kirikus ja 21. juulil Toronto baptistikirikus

  5. Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies

    International Nuclear Information System (INIS)

    Rettie, A.E.; Boberg, M.; Rettenmeier, A.W.; Baillie, T.A.

    1988-01-01

    The cytochrome P-450-mediated desaturation of valproic acid (VPA) to its hepatotoxic metabolite, 2-n-propyl-4-pentenoic acid (4-ene-VPA), was examined in liver microsomes from rats, mice, rabbits and humans. The highest substrate turnover was found with microsomes from rabbits (44.2 +/- 2.7 pmol of product/nmol P-450/15 min), while lower activities were observed in preparations from human, mouse, and rat liver, in that order. Pretreatment of animals with phenobarbital led to enhanced rates of formation of 4-ene-VPA in vitro and yielded induction ratios for desaturation ranging from 2.5 to 8.4, depending upon the species. Comparative studies in the rat showed that phenobarbital is a more potent inducer of olefin formation than either phenytoin or carbamazepine. The mechanism of the desaturation reaction was studied by inter- and intramolecular deuterium isotope effect experiments, which demonstrated that removal of a hydrogen atom from the subterminal C-4 position of VPA is rate limiting in the formation of both 4-ene- and 4-hydroxy-VPA. Hydroxylation at the neighboring C-5 position, on the other hand, was highly sensitive to deuterium substitution at that site, but not to deuteration at C-4. Based on these findings, it is proposed that 4-ene- and 4-hydroxy-VPA are products of a common P-450-dependent metabolic pathway, in which a carbon-centered free radical at C-4 serves as the key intermediate. 5-Hydroxy-VPA, in contrast, derives from an independent hydroxylation reaction

  6. 6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.

    Science.gov (United States)

    Kuntze, Kevin; Shinoda, Yoshifumi; Moutakki, Housna; McInerney, Michael J; Vogt, Carsten; Richnow, Hans-Hermann; Boll, Matthias

    2008-06-01

    In anaerobic bacteria, most aromatic growth substrates are channelled into the benzoyl-coenzyme A (CoA) degradation pathway where the aromatic ring is dearomatized and cleaved into an aliphatic thiol ester. The initial step of this pathway is catalysed by dearomatizing benzoyl-CoA reductases yielding the two electron-reduction product, cyclohexa-1,5-diene-1-carbonyl-CoA, to which water is subsequently added by a hydratase. The next two steps have so far only been studied in facultative anaerobes and comprise the oxidation of the 6-hydroxyl-group to 6-oxocyclohex-1-ene-1-carbonyl-CoA (6-OCH-CoA), the addition of water and hydrolytic ring cleavage yielding 3-hydroxypimelyl-CoA. In this work, two benzoate-induced genes from the obligately anaerobic bacteria, Geobacter metallireducens (bamA(Geo)) and Syntrophus aciditrophicus (bamA(Syn)), were heterologously expressed in Escherichia coli, purified and characterized as 6-OCH-CoA hydrolases. Both enzymes consisted of a single 43 kDa subunit. Some properties of the enzymes are presented and compared with homologues from facultative anaerobes. An alignment of the nucleotide sequences of bamA(Geo) and bamA(Syn) with the corresponding genes from facultative anaerobes identified highly conserved DNA regions, which enabled the discrimination of genes coding for 6-OCH-CoA hydrolases from those coding for related enzymes. A degenerate oligonucleotide primer pair was deduced from conserved regions and applied in polymerase chain reaction reactions. Using these primers, the expected DNA fragment of the 6-OCH-CoA hydrolase genes was specifically amplified from the DNA of nearly all known facultative and obligate anaerobes that use aromatic growth substrates. The only exception was the aromatic compound-degrading Rhodopseudomonas palustris, which uniquely uses a modified benzoyl-CoA degradation pathway. Using the oligonucleotide primers, the expected DNA fragment was also amplified in a toluene-degrading and a m

  7. Stomatološki pregledi tijekom trudnoće

    OpenAIRE

    Polašek, Antonia

    2017-01-01

    Trudnoća je jedinstveno vrijeme u životu žene, popraćeno raznovrsnim fiziološkim, anatomskim i hormonskim promjenama koje mogu utjecati na pružanje oralne zdravstvene zaštite. Razumijevanje tih uobičajenih promjena nužno je za pružanje kvalitetne njege trudnica. Međutim, trudnice kao pacijenti nisu medicinski ugrožene i ne bi trebalo odgađati provođenje potrebnog dentalnog tretmana. U trudnoći se javljaju pojedine promjene stanja zubi i okolnog tkiva usne šupljine, ali se one većinom mogu...

  8. Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of antiproliferative effects in vitro.

    Science.gov (United States)

    Vessières, Anne; Top, Siden; Pigeon, Pascal; Hillard, Elizabeth; Boubeker, Leila; Spera, Daniela; Jaouen, Gérard

    2005-06-16

    We report here the synthesis and the strong and unexpected antiproliferative effect of the organometallic diphenolic compound 1,1-bis(4'-hydroxyphenyl)-2-ferrocenyl-but-1-ene (4) on both hormone-dependent (MCF7) and -independent (MDA-MB231) breast cancer cells (IC(50) = 0.7 and 0.6 microM). Surprisingly, 6 [1,2-bis(4'-hydroxyphenyl)-2-ferrocenyl-but-1-ene], the regioisomer of 4, shows only a modest effect on these cell lines. This pertinent organometallic modification seems to trigger an intracellular oxidation of the structurally favorable compound 4, leading to the generation of a potent cytotoxic compound.

  9. Synthesis, antimicrobial and cytotoxicity evaluation of new cholesterol congeners

    Directory of Open Access Journals (Sweden)

    Mohamed Ramadan El Sayed Aly

    2015-10-01

    Full Text Available 3β-Azidocholest-5-ene (3 and (3β-3-(prop-2-yn-1-yloxycholest-5-ene (10 were prepared as substrates to synthesize a variety of three-motif pharmacophoric conjugates through CuAAC. Basically, these conjugates included cholesterol and 1,2,3-triazole moieties, while the third, the pharmacophore, was either a chalcone, a lipophilic residue or a carbohydrate tag. These compounds were successfully prepared in good yields and characterized by NMR, MS and IR spectroscopic techniques. Chalcone conjugate 6c showed the best antimicrobial activity, while the lactoside conjugate 27 showed the best cytotoxic effect in vitro.

  10. Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima Seeds

    Directory of Open Access Journals (Sweden)

    Reiko Tanaka

    2013-05-01

    Full Text Available Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1, 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2, and multiflora-7,9(11-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3, were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11-diene-3a-29-diol 3-benzoate (5 exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.

  11. Three new multiflorane-type triterpenes from pumpkin (Cucurbita maxima) seeds.

    Science.gov (United States)

    Kikuchi, Takashi; Takebayashi, Mika; Shinto, Mayumi; Yamada, Takeshi; Tanaka, Reiko

    2013-05-14

    Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3a-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.

  12. Gender stereotypes analysis in cartoons broadcasted on Croatian televisions

    OpenAIRE

    Rudančić, Vlatka

    2015-01-01

    Rodni stereotipi postoje od kada postoje muškarci i žene, njihovo značenje roda i spola. Od samih početaka razvoja pismenosti (od doba Aristotela) muškarci su bili oni koji su išli u lov i čije se mišljenje uvažavalo, dok su žene ostajale doma, rađale djecu i brinule se o njima. Istraživanje se temelji na osamdeset analiziranih crtanih filmova koji se prikazuju na hrvatskim nacionalnim TV postajama te prikazuju postojanje rodnih stereotipa u svim pregledanim materijalima. Metoda koja se koris...

  13. Two new cucurbitane triterpenoids from the seeds of Momordica charantia.

    Science.gov (United States)

    Ma, Lin; Yu, Ai-Hua; Sun, Li-Li; Gao, Wan; Zhang, Meng-Meng; Su, Ya-Lun; Liu, Hua; Ji, Teng-Fei; Li, Di-Zao

    2014-01-01

    Two new cucurbitane triterpenoids 1 and 2 were isolated, together with six known compounds, from the seeds of Momordica charantia L. The structures of new compounds were determined to be 3-O-{[β-d-galactopyranosyl(1 → 6)]-O-β-d-galactopyranosyl}-23(R), 24(R), 25-trihydroxycucur-bit-5-ene (1), 3-O-[β-d-galactopyranosyl]-25-O-β-d-galactopyranosyl-7(R), 22(S), 23(R), 24(R), 25-pentahydroxycucurbit-5-ene (2), respectively. Their structures were elucidated by the combination of mass spectrometry, one- and two-dimensional NMR experiments and chemical reactions.

  14. ANALISA TINGKAT BAHAYA DAN KERENTANAN BENCANA GEMPA BUMI DI WILAYAH NUSA TENGGARA TIMUR (NTT

    Directory of Open Access Journals (Sweden)

    Ni Made Rysnawati

    2017-02-01

    Full Text Available East Nusa Tenggara is a region in Indonesia which included in the category of hazard prone to earthquakes, because it is flanked by two earthquakes zones, (subduction zone at the south and back arc trust in the north. It is also vulnerable to earthquake disasters because of high population density. These conditions would threaten the safety of lives and property of the population, so it needs to be research to analyze the level of earthquake hazard and vulnerability in East Nusa Tenggara. For identification of the level of hazard and the vulnerability of the earthquake in this study using two factors: the danger factor with indicator Peak Ground Acceleration, vulnerability factors with indicators of population density districts in East Nusa Tenggara. The calculation of the value of PGA use attenuation function of Fukushima and Tanaka. From the calculation of the data obtained that has a very high earthquake hazard is in Ende and Alor district, while the district has a very high risk of vulnerability is in Sikka, Sumba Barat Daya and Sabu Raijua.

  15. THE AMERINDIANS IN THE THREADS OF CHRISTIAN AFTERLIFE

    Directory of Open Access Journals (Sweden)

    Glória Kok

    2008-06-01

    Full Text Available This article examines the work of Jesuits on the reorganization of the dead´s world of the Tupi-Guarani Indians, in order to fit it in the christian model of afterlife. In consequence, images and visions related to Heaven, Hell and Purgatory were disseminated and translated in multiple forms by the Indians of Portuguese America during the cathechization´s process.

  16. Ühised juured: Kesk-Euroopa disain Iisraelis / Kai Lobjakas

    Index Scriptorium Estoniae

    Lobjakas, Kai, 1975-

    2012-01-01

    Näitus "Common Roots. Design Map on Central Europe" Holoni disainimuuseumis kuni 23.02.2013. Eestist esindavad nüüdisaegset disaini Sixten Heidmets / Fellin Furniture, Monika Järg, Jüri Kermik, Kerttu Laane, Jaanus Orgusaar, Kristi Paap, Villu Pruulmann, Ruumilabor, Pavel Sidorenko ja Igor Volkov. Ajaloolise disaini osas on väljas Helle Gansi, Maile Grünbergi ning Tarbeklaasi ja Estoplasti tööd

  17. Catábasis y resurreción

    Directory of Open Access Journals (Sweden)

    Pilar González Serrano

    1999-01-01

    Full Text Available La idea de la «catábasis»; es decir, el descenso al infierno y la posterior salida del mismo (anábasis o resurrección aparece inmersa desde la más remota antigüedad, en el marco de las creencias funerarias de casi todas las civilizaciones del mundo. Así pues, el culto a los muertos ha sido un hecho desde el Neolítico (o desde las fases finales del Paleolítico tanto por necesidades higiénicas, como de piedad hacia los difuntos. Otra creencia funeraria de la antigüedad fue la necesidad de descender al infierno cuando alguien quería hablar o tener algún tipo de relación con los hombres sabios que moraban en el «ínframundo». Así, los dioses más importantes de la Naturaleza (Marduk, Heracles, Orfeo, los Dióscuros, Odiseo, Eneas, etc. descendieron a los infiernos donde todos tuvieron inolvidables experiencias. Lo importante era poder imaginar una escapada dei mundo de ias tinieblas, donde los muertos, en el mejor de los casos, son sombras descarnadas, como sucedía en el Hades de los griegos.The idea of «catabasis», which means the descent to Hell and later departing it («anabasis» or resurrection, appears in the funeral beliefs of almost all civilisations since the remotest antiquity. Thus, worship of the dead has been a feature since Neolithic (or last period of the Palaeolithic for both reasons of hygiene and piety to the deceased. Another funeral belief in antiquity was the need to descend to Hell when somebody wanted to speak or to have some contact with the wise men that were at the «netherworld». So, the most important Gods of Nature (Marduk, Osiris, Adonis, Attis, Persephone and the most famous héroes (Theseus, Heracles, Orpheus, the Dióscuros, Odysseus, Eneas, etc. descended to Hell, were they all had unforgettable experiences.

  18. Uus eesti disain / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2009-01-01

    2009. a. disainiöö raames toimunud Eesti Disainerite Liidu algatatud konkursi "Eesti disain ja elukeskond 2009" disainikategooria kümne finalisti tööde tutvustus. 1. koha sai moodulrattahoidja "Rohi" (disain: Keha3), 2. koha vurr-tool "Kiirendi" (disain: Jaanus Orgusaar), 3. koha lastemööbel "Smart kid" (disain: Pavel Sidorenko, Heiki Must)

  19. Modernne kastmaja Nõmmel / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    1999-01-01

    Projekteerija: arhitektuuribüroo Mark & Tamm. Konstruktiivne osa: inseneribüroo Randväli Karema. Arhitektid Ülar Mark, Kalle Komissarov. Kahekorruseline maja Vabaduse pst. ääres on mahutatud puude vahele kitsale alale. Kommenteerib Ü. Mark.

  20. Ametlikke annetusi 2005. aastal / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2005-01-01

    Saksamaa suursaadik Julius Bobinger kinkis 50 saksakeelset "Kalevipoega" Eesti Kultuuriministeeriumile, kes edastas need maakonnaraamatukogudele, teadusraamatukogudele ja Kreutzwaldi muuseumile Võrus

  1. Professor Pekka Puska loengud / Ene Indermitte

    Index Scriptorium Estoniae

    Indermitte, Ene, 1967-

    2004-01-01

    Soome Rahvatervishoiu Instituudi direktor, Põhja-Karjala projekti juht prof Pekka Puska peab Tartu ülikoolis loengu "The North Karelia Projekt in Finland and lessons for global chronic disease prevention"

  2. Tagasivaade elule ja ajale / Ene Liivik

    Index Scriptorium Estoniae

    Liivik, Ene, 1933-

    2010-01-01

    Artikkel põhineb kahel käsikirjal "Tagasi waade möödunud elule ja ajale. Utškuju-Tarhani küla aja lugu. 50ne aastane juubel" ja "Lahtised lehed", mille autoriks on Helmi Koolmann. Käsikirjas meenutavad Helmi ja tema abikaasa Rein Koolmann Krimmis elatud aastaid

  3. Hüdra aastasada / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet

    1997-01-01

    Arvustus: Galsworthy, John. Peatüki lõpp : Üle jõe / tlk. Jüri ja Liisi Ojamaa. Tallinn : Eesti Raamat, 1997; Amis, Kingsley. qnneseen Jim / tlk. Urve Hanko. Tallinn : Eesti Raadio, 1997; Boyd, William. Sinine pärastlõuna / tlk. Virve Krimm. Tallinn : Varrak, 1997. Briti XX saj. kirjanduse ülevaade

  4. Vaesusriski muutused Eestis / Ene-Margit Tiit

    Index Scriptorium Estoniae

    Tiit, Ene-Margit, 1934-

    2006-01-01

    Seoses Eesti majanduse kiire arenguga tellis sotsiaalministeerium 2005. aastal uue tarbimiskaalude hinnangu, mille aluseks olid leibkonna eelarvehinnangu andmed aastaist 2000-2004 ning hinnati erineva struktuuriga leibkondade tarbimiskulutusi. Diagrammid. Graafikud

  5. Küberjulgeolekule teed rajades / Ene Ergma

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2007-01-01

    Riigikogu esimees analüüsib aprillisündmustega kaasnenud küberrünnakute kui ühe terrorismi erivormi tagamaid, toob välja vajaduse kujundada küberrünnakute suhtes Euroopa Liidus ja NATO-s ühtne poliitika

  6. Eesti Etnograafia Ring Kanadas / Ene Runge

    Index Scriptorium Estoniae

    Runge, Ene, 1919-1999

    1993-01-01

    Etnograafia Ring looodi 1971.a ja on pidevalt õpetanud käsitööd, pidanud loenguid eesti ja inglise keeles, korraldanud näitusi ja loonud eesti sektsiooni Royal Ontario Museumi ja Canadian National Museumi juurde kultuurivara säilitamiseks. Seltsi 20. aastapäevaks oli välja antud 61 õppekirja, lisaks õpetused ajakirjas "Triinu" ja õppefilmid, fotod ja diapositiivid, abi on antud samasugustele ringidele Rootsis ja Austraalias, ERM-ile saadeti 1991. a üle 200 rahvakultuuri eseme

  7. ŽENE U ZNANOSTI: STAKLENI STROP

    OpenAIRE

    PRIJIĆ-SAMARŽIJA, Snježana; AVELINI HOLJEVAC, Ivanka; TURK, Marko

    2009-01-01

    Temeljni cilj članka jest propitivanje postojanja "staklenoga stropa" ili podzastupljenosti žena na rukovodećim položajima u ustanovama znanosti i visokog obrazovanja kakvo je Sveučilište u Rijeci, uključivo i mehanizama koji ga uzrokuju. Prvi dio članka sadrži kratak pregled i analizu empirijskih rezultata istraživanja provedenog na Sveučilištu u Rijeci, koji nedvojbeno upućuju na prisutnost efekta "staklenoga stropa" i, shodno tome, na postojanje prikrivene primarne i s...

  8. Ene Üleoja: "Kreeki ei ületa praegu keegi" / Ene Üleoja ; intervjueerinud T[iina] M[attisen

    Index Scriptorium Estoniae

    Üleoja, Ene, 1937-

    2010-01-01

    Heliloojate Liidu ja Pirita kloostri poolt välja kuulutatud heliloominguvõistluse "Taaveti laul" tulemustest žürii liikme E. Üleojaga. Konkursi lõppkontsert toimus 10. veebr. Pirita kloostris, esines Voces Musicales Endrik Üksvärava juhatusel

  9. Mechanical Characterization of Polydopamine-Assisted Silver Deposition on Polymer Substrates

    Science.gov (United States)

    Cordes, Amanda Laurence

    Inspired by the adhesive proteins in marine mussels, polydopamine has become a popular adhesive ad-layer for surface functionalization of a variety of substrates. Based on the chemistry of the dopamine monomer, amine and thiol functional groups are hypothesized to increase adhesion between polymer substrates and polydopamine thin films. This hypothesis was the central motivation for development of a tailorable thiol-ene system in order to study the effects of substrate chemistry on polydopamine adhesion. While polydopamine-adhered silver has been studied on a variety of substrates, no in depth mechanical characterization has been performed and to date, no research has been published on thiol-enes coated in polydopamine-adhered silver. The purpose of this study was to characterize the mechanical durability and adhesion properties of a polydopamine-adhered silver film on commercial substrates and a tailorable thiol-ene system. Polydopamine and silver coatings were deposited on a variety of polymer substrates through a simple dip-coat process. The polydopamine forms a thin uniform adhesive layer and the silver deposits in a discontinuous manner with a nanoparticle sized base layer covering the full surface and micron-sized clusters adhered sporadically on top. Mechanical tensile testing was performed to characterize the durability of the silver coating on commercial polymers. Coated nylon and HDPE showed no signs of degradation or delamination of the polydopamine-adhered silver coating up to 30% strain although both substrates showed large plastic deformation. Peel tests were performed on both commercial polymers as well as a tailorable thiol-ene system. Results support the hypothesis that polydopamine adhesion is increased with the presence of functional groups. Parts of the HDPE sample were cleanly peeled, but silver patches were left sporadically across the surface pointing to weaker adhesion between polyethylene and polydopamine. A high adhesive strength tape was

  10. National Energy Strategy 2012-2026; Estrategia Nacional de Energia 2012-2026

    Energy Technology Data Exchange (ETDEWEB)

    Direccion General de Planeacion Estrategica, Secretaria de Energia, Mexico, D.F. (Mexico)

    2012-02-15

    In compliance with the provisions of the Congress, the National Energy Strategy 2012-2026 (NES) outlines the direction of the Mexican energy sector with a horizon of 15 years. Its vision is supported by a comprehensive planning exercise that collects information from each of the parastatals and decentralized administrative bodies that make up the sector. This ensures the accuracy and relevance of information presented throughout the document and integrates the perspectives of all public bodies involved. From that interagency and interdisciplinary approach, the NES provides energy policy guidelines that are essential to realize this vision. In turn, these serve to construct detailed criteria of public policy. Finally, the NES raises specific targets for 2026, which can be achieved based on the implementation of actions considered within the planning guidelines. The NES is a prospective tool and indicative that stands as a useful tool for any plan or program. To serve as an instrument of dialogue between institutions and authorities, NES is a document with a solid vision and a planned role in Mexico's energy policy. [Spanish] En cumplimiento por lo establecido por el Congreso de la Union, la Estrategia Nacional de Energia 2012-2026 (ENE) delinea el rumbo del sector energetico mexicano con un horizonte de 15 anos. Su vision esta sustentada en un ejercicio integral de planeacion que recaba informacion de cada una de las entidades paraestatales y organos administrativos desconcentrados que conforman el sector. Esto garantiza la precision y pertinencia de la informacion presentada a lo largo del documento e integra las perspectivas de todos los entes publicos involucrados. A partir de ese enfoque interinstitucional e interdisciplinario, la ENE establece los lineamientos de politica energetica que son indispensables para materializar esta vision. A su vez, estos sirven para construir criterios detallados de politica publica. Finalmente, la ENE plantea metas concretas

  11. Exposure to volatile organic compounds in an ethanol and gasoline service station.

    Science.gov (United States)

    de Oliveira, K M P G; Martins, E M; Arbilla, G; Gatti, L V

    2007-08-01

    The present study was conducted to determine the VOCs concentrations in a service station located in a residential and commercial area in the city of Rio de Janeiro. This is, to our knowledge, the first published determination in Brazil, where both ethanol and ethanol-blended gasoline are used. Electro polished, stainless steel, evacuated canisters were used for sampling. The analysis was performed by gaschromatography with flame ionization detection (CG-FID) and by gas chromatography-mass spectrometry (CG-MS). A total of 80 and 56 compounds were determined in samples collected at the service station and control location, respectively. The most abundant compounds at the service station were in order of decreasing concentration (units: microg m(-3)): 2-methylbutane (1,715.7), 2-methylbut-1-ene (1,043.2), isobutene (758.8), 2-methylprop-1-ene (703.7), 2-methylpentane (492.1), pentadi-1,3-ene (189.7), toluene (157.0), benzene (144.5), but-2-ene (126.3) and m,p-xylene (123.2). A mean concentration of 144.5 microg m(-3) was determined for benzene, this value is about ten times the concentration determined in the control location in this work and about 70 times the value determined in other locations of Rio de Janeiro using charcoal cartridges for the sampling. The mean benzene/toluene ratios are 0.92 and 0.31 in the service station and control location, respectively. Since in Brazil service station workers are employed to fill customer's cars (self-service is not commonly used) the possible risk of cancer of these workers should be evaluated in a future study.

  12. FY 2001 report on the results of the survey of the environmentally friendly type energy community project. Feasibility survey of the commercialization of the gasification melting system use heat supply business using container packing waste plastic and other waste as raw materials; 2001 nendo kankyo chowa gata energy komyuniti jigyo. Gaska yoyu system wo mochiita yoki hoso kei hai purasuchikku oyobi sonota no haikibutsu wo genryo to suru netsu kyokyu jigyo no jigyoka F/S chosa chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-03-01

    As to gasification melting facilities (Eco-Ene center) using container packing waste plastic and other waste as raw materials in 'the Eco-town Kochi City - Business Project,' study/evaluation of environmental conservation and business profitability were conducted. In Eco-Ene Center, power generation (power supply to users: 1,295 kW) and heat supply (27 GJ/h at maximum) are conducted using the gas product obtained from the combustion of waste. The environmental effect of introduction of Eco-Ene Center is as follows: energy conservation: 51,350-113,594 GJ/y, environmental pollution gas reduction: 1,128-4,987 t-CO2, 1,441-6,691 kg-NOx, 2,965-6,447 kg-SOx, 27,309 {mu}g-TEQ/m{sup 3} dioxin. As a result of the study of economical efficiency, the following was found out: In securing the ending cash balance such as personnel expenses, land lease cost and transportation cost, the subject is the acceptance price of container packing plastic from which a half of the profit can get, and it is necessary to receive subsidy for 1/2 of the price and reduce operating expenses. (NEDO)

  13. Four new neolignans isolated from Eleutherococcus senticosus and their protein tyrosine phosphatase 1B inhibitory activity (PTP1B).

    Science.gov (United States)

    Zhang, Le; Li, Ban-Ban; Li, Hao-Ze; Meng, Xiao; Lin, Xin; Jiang, Yi-Yu; Ahn, Jong-Seog; Cui, Long

    2017-09-01

    Four new compounds, erythro-7'E-4-hydroxy-3,3'-dimethoxy-8,5'-oxyneoligna-7'-ene-7,9-diol-9'-al (1), (7S,8S)-4-hydroxy-3,1',3'-trimethoxy-4',7-epoxy-8,5'-neolign-9-ol (5), (7S,8S,7'E)-5-hydroxy-3,3'-dimethoxy-4',7-epoxy-8,5'-neolign-7'-ene-9,9'-diol (6) and (7S,8S,7'E)-5-hydroxy-3,3',9'-trimethoxy-4'-7-epoxy-8,5'-neolign-7'-ene-9-ol (7). Along with four known compounds (2-4, 8) were isolated from the EtOAc-soluble extract of Eleutherococcus senticosus. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the compounds were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, compounds 1-4 and 6-8 were found to exhibit selective inhibitory activity on PTP1B with IC 50 values ranging from 17.2±1.6 to 32.7±1.2μM. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Androgen and Progesterone Receptors Are Targets for Bisphenol A (BPA, 4-Methyl-2,4-bis-(P-HydroxyphenylPent-1-Ene--A Potent Metabolite of BPA, and 4-Tert-Octylphenol: A Computational Insight.

    Directory of Open Access Journals (Sweden)

    Mohd Rehan

    Full Text Available Exposure to toxic industrial chemicals that have capacity to disrupt the endocrine system, also known as endocrine disrupting chemicals (EDCs, has been increasingly associated with reproductive problems in human population. Bisphenol A (BPA; 4,4'-(propane-2,2-diyldiphenol and 4-tert-octylphenol (OP; 4-(1,1,3,3-tetramethylbutylphenol are among the most common environmental contaminants possessing endocrine disruption properties and are present in plastics, epoxy resins, detergents and other commercial products of common personal and industrial use. A metabolite of BPA, 4-Methyl-2,4-bis(4-hydroxyphenylpent-1-ene (MBP is about 1000 times more biologically active compared to BPA. Epidemiological, clinical, and experimental studies have shown association of BPA and OP with adverse effects on male and female reproductive system in human and animals. The endocrine disruption activity can occur through multiple pathways including binding to steroid receptors. Androgen receptor (AR and progesterone receptor (PR are critical for reproductive tract growth and function. Structural binding characterization of BPA, MBP, and OP with AR and PR using molecular docking simulation approaches revealed novel interactions of BPA with PR, and MBP and OP with AR and PR. For BPA, MBP, and OP, five AR interacting residues Leu-701, Leu-704, Asn-705, Met-742, and Phe-764 overlapped with those of native AR ligand testosterone, and four PR interacting residues Leu-715, Leu-718, Met-756, and Met-759 overlapped with those of PR co-complex ligand, norethindrone. For both the receptors the binding strength of MBP was maximum among the three compounds. Thus, these compounds have the potential to block or interfere in the binding of the endogenous native AR and PR ligands and, hence, resulting in dysfunction. The knowledge of the key interactions and the important amino-acid residues also allows better prediction of potential of xenobiotic molecules for disrupting AR- and PR

  15. Täna austatakse kunstnik Edgar Valteri ja helilooja Raimo Kangro mälestust

    Index Scriptorium Estoniae

    2009-01-01

    Edgar Valteri 80. sünniaastapäeva tähistav konverents, tema raamatu "Karid ja kõrgused. I" (Tartu : Elmatar, 2009) esitlus ning Helle Laanpere ja Külli Leppiku koostatud näituse "Edgar Valter 80. Vaikse vaatlemise keeles" avamine 21. septembril Eesti Rahvusraamatukogus. Eesti Lastekirjanduse Keskuse Edgar Valteri galeriis näitus "Ilusad pildid". Estonia kontserdisaalis Raimo Kangro 60. sünniaastapäevale pühendatud kontsert

  16. Pärnu on Eesti funktsionalismi lipulaev / Anu Villmann

    Index Scriptorium Estoniae

    Villmann, Anu

    2006-01-01

    Pärnu uusehitistest - Seedri tänava elamud (arhitekt Kalle Vellevoog), kortermaja Tammsaare ja Lehe tänava nurgal (arhitekt Tanel Tuhal arhitektuuribüroost Luhse ja Tuhal) ja kesklinna koolide võimla (arhitektid Katrin Koov, Siiri Vallner, Kaire Nõmm ja Heidi Urb arhitektuuribüroost KAVA KAVA). Pärnu arhitektuurist võtavad sõna Pärnu Linnavalitsuse arhitekt Karri Tiigisoon, Helle-Ann Urgard, Tanel Tuhal, Hardi Lehemaa ja Toomas Unt

  17. Building Partnership Capacity at the Ministerial Level to Improve Gender Equality

    Science.gov (United States)

    2014-06-13

    suggested I read some of the research of Dr. Aili Tripp and Peace Medie which were of considerable help to my literature review. Most importantly, I am...59 The Consequences of Culture–Policy vs . Implementation ....................................... 62 Section Three: The Whole of Government...2013, 387). The 2008 documentary , Pray the Devil Back to Hell tells the story of a group of Liberian women who would not succumb to fear. The film

  18. Luistelulaite : jatkokehittely

    OpenAIRE

    Sorsa, Anssi

    2015-01-01

    Opinnäytetyön aihe on Heikki Kajastien / Gloway Invent Oy:n kehittelemän luistelulaitteen prototyypin jatkokehittely. Luistelulaitteella voidaan harjoittaa luistelijalle tärkeitä jalan lihaksia, joiden harjoittaminen muilla olemassa olevilla kuntosalilaitteilla ei onnistu. Koska laitteen liikeratoja ja kuntoiluvastuksia vastaavia tai lähellä olevia kuntosalilaitteita ei ole olemassa, vaan liikeradat muistuttavat enemmänkin jalkojen suoristaja ja loitontaja -laitteiden välimuotoa, niin laittee...

  19. Skønhed og rædsel i den nye Pharma Science Building

    DEFF Research Database (Denmark)

    Reeh, Henrik

    2016-01-01

    Reportage fra et fælles besøg i den nyligt indviede PharmaScience Building, Københavns Universitet, juni 2016. Teksten om mødet mellem journalist og forsker på den ene side og bygningen og dens brugere på den anden side. Journalist Christoffer Zieler henviser til Henrik Reehs separat offentliggjo......Reportage fra et fælles besøg i den nyligt indviede PharmaScience Building, Københavns Universitet, juni 2016. Teksten om mødet mellem journalist og forsker på den ene side og bygningen og dens brugere på den anden side. Journalist Christoffer Zieler henviser til Henrik Reehs separat...

  20. Lipid constituents of the red alga Acantophora spicifera

    Digital Repository Service at National Institute of Oceanography (India)

    Wahidullah, S.; DeSouza, L.; Govenkar, M.B.

    to report another novel steroid cholest-4-ene-3:~, 6/3- diol (4), cholest-4-ene-3-one (1), lauric acid or dode- canoic acid (3) and o-phthalic acid bis-(2 ethyl nonyl)- ester (2). RESULTS AND DISCUSSIONS Compound 1 had tH NMR (CDC13) spectrum....p. 46 C and the formula of Ct2H2402 was assigned on the basis of its mass spectrum which showed peaks at m/z 183 (M+-I7) and m/z 155 (M+-45) with a weak molecular ion peak at m/z 200. The ~ H NM R spectrum 200 MHz (CDC13) showed a triplet at 6 0.9 (3...

  1. Obveznopravni odnosi u prijevozu živih životinja morem

    Directory of Open Access Journals (Sweden)

    Ivo Grabovac

    2006-08-01

    Full Text Available Prijevoz živih životinja morem spada u tzv. posebne prijevoze. Žive životinje su tijekom prijevoza izložene posebnim, samo njima kao živim bićima svojstvenim rizicima. Mjerodavne međunarodne konvencije i domaći propisi imaju neka posebna rješenja u prijevozu ove vrste robe, kojima je zapravo svrha omogućiti pogodniji pravni položaj prijevoznika. Autor u ovom radu ističe određene osobitosti u sadržaju prava i obveza ugovaratelja iz prijevoza živih životinja morem, a na temelju međunarodnih konvencija i nacionalnih propisa, osobito Pomorskog zakonika Republike Hrvatske.

  2. Storie ‘vere’ ed eroine dei romanzi. Rappresentare la Somalia in 'Ilaria Alpi. La ragazza che voleva raccontare l’inferno' e 'Non dirmi che hai paura'

    Directory of Open Access Journals (Sweden)

    Simone Brioni

    2016-09-01

    Full Text Available ‘True’ Stories and Heroines in Novels: The Representation of Somalia in Ilaria Alpi: The Young Woman Who Wanted to Narrate Hell and Don’t Tell Me You Are AfraidThis article analyses Gigliola Alvisi’s Ilaria Alpi: La ragazza che voleva raccontare l’inferno [Ilaria Alpi: The Young Woman Who Wanted to Narrate the Hell] (2014 and Giuseppe Catozzella’s Non dirmi che hai paura [Don’t Tell Me You Are Afraid] (2014, two novels that deal with two recent events in Somali and Italian history, the killing of the journalist Ilaria Alpi in Mogadishu in 1994 and the death of Samia Yosuf Omar while she was trying to reach the Italian shores from Libya by boat. Alvisi’s text is analysed in comparison with other fictional and journalistic representations of Ilaria Alpi, while Non dirmi che hai paura is examined through what Catozzella considers the two constitutive dimensions of the novel: documentation and identification. Drawing on Stefano Jossa’s reflections on the construction of literary heroes, the article challenges Alvisi’s and Catozzella’s claims that they represent ‘true stories’. The article also argues that the main characters of these literary works are portrayed as heroines and role models for the emancipation of Muslim women.

  3. Prague quadrennial 14.06-20.06/2007. Short play: crisis of forties flood after rain/ Vladimir Anshon

    Index Scriptorium Estoniae

    Anšon, Vladimir, 1963-

    2010-01-01

    XI rahvusvahelisest Praha lavastuskunstnike kvadriennaalist (Prague Quadrennial). Eesti rahvuslikust väljapanekust, kuraator Ene-Liis Semper ja Eesti Kunstiakadeemia väljapanekust, kuraator Lilja Blumenfeld

  4. Agenda kultuuripealinna ArtGendast / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    1998-01-01

    24. maini Stockholmi Kulturhusetis avatud Balti mere maade noortebiennaalist 'ArtGenda'. Peakorraldaja Beate Sydhoff. Eestlaste - Ene-Liis Semper, Martin Pedanik, Andrus Kõresaar, Marko Laimre - esinemisest.

  5. Metabolism of 19-methyl-substituted steroids by human placental aromatase

    International Nuclear Information System (INIS)

    Beusen, D.D.; Carrell, H.L.; Covey, D.F.

    1987-01-01

    The 19-methyl analogues of androstenedione and its aromatization intermediates (19-hydroxyandrostenedione and 19-oxoandrostenedione) were evaluated as substrates of microsomal aromatase in order to determine the effect of a 19-alkyl substituent on the enzyme's regiospecificity. Neither the androstenedione analog [10-ethylestr-4-ene-3,17-dione (1c) nor the 19-oxoandrostenedione analog [10-acetylestr-4-ene-3,17-dione (3c)] was converted to estrogens or oxygenated metabolites by placental microsomes. In contrast, both analogues of 19-hydroxyandrostenedione [10-[(1S)-1-hydroxyethyl] extr-4-ene-3,17-dione (2c) and 10-[(1R)-1-hydroxyethyl]estr-4-ene-3,17-dione (2e)] were converted to the intermediate analog 3c in a process requiring O 2 and either NADH or NADPH. No change in enzyme regiospecificity was detected. The absolute configuration of 2e was determined by X-ray crystallography. Experiments with 18 O 2 established that 3c generated from 2c retained little 18 O ( 18 O (≅ 70%). All four 19-methyl steroids elicited type I difference spectra from placental microsomes in addition to acting as competitive inhibitors of aromatase. Pretreatment of microsomes with 4-hydroxyandrostenedione (a suicide inactivator of aromatase) abolished the metabolism of 2c and 2e to 3c, as well as the type I difference spectrum elicited by 2c and 2e. The failure of 2c, 2e, and 3c to undergo aromatization was rationalized in the context of a mechanistic proposal for the third oxygenation of aromatase requiring hydrogen abstraction at C 1 of 19,19-dihydroxyandrostenedione, homolytic cleavage of the C 10 -C 19 bond, and oxygen rebound at C 19

  6. Aportaciones al conocimiento de la compresión tardía en la Cordillera Ibérica centro-oriental: la cuenca neógena inferior del Mijares (Teruel-Castellón

    Directory of Open Access Journals (Sweden)

    Paricio Cardona, J.

    1986-10-01

    Full Text Available The lower Neogene deposits of the Mijares valley (mainly fluvial facies are filling three paralell• grabens controlled by synsedimentary ENE normal faults. This structural pattern is created during a moderate compression phase with an ENE horizontal σ1 axis which sometimes can be permuted with the vertical σ2. Afterwards. a second SSE to S compression affects these deposits. The age of the basin can be established in the Upper Aragonian-Lower Vallesian bested on the Micromamal fauna found in two localities. Other sites in the cetral-oriental lberian Chain also show compressive deformations in well-dated deposits of Agenian and Aragonian ages. The compression still continues in this region during the Lower and Middle Miocene, the passage to the extension regime talking place in the Vanesian.

    Las facies esencialmente fluviales que integran la unidad interior~ del valle medio del Mijares se depositan en tres grabens paralelos controlados por fallas sinsedimentarias ENE de componente normal. Este dispositivo estructural se crea en el curso de una etapa. compresiva de intensidad moderada, con un σ1 según ENE, que eventualmente se intercambia con σ2 vertical. Una segunda etapa de compresión SSE a S afecta posteriormente a esta unidad, datada en el Astaranciense-Vallesiense gracias a la fauna de micromamíferos proporcionada por dos yacimientos. Otras localidades de la Cadena Ibérica centro-oriental registran asimismo deformaciones compresivas en depósitos bien datados entre el Ageniense y el Aragoniense. Aunque sin producir apenas pliegues, el régimen compresivo perdura aún claramente en este sector de la cadena durante toda la primera mitad del Mioceno, siendo en el Vallesiense cuando se produce el tránsito definitivo a la distensión.

  7. Hvem underviser i massekommunikation? - hvordan? - og hvad mangler?

    Directory of Open Access Journals (Sweden)

    Helle Alrø

    1987-08-01

    Full Text Available Disse spørgsmål har Helle Arø og Birgitte Tufte forsøgt at få besvaret ved hjælp af et spørgeskema, der blev udsendt via de faglige foreningers blade. Svarprocenten har indtil nu ikke været stor, men alligevel kan de indkomne svar nok belyse tendenserne inden for medieundervisningen på forskellige uddannelsestrin: i folkeskolen, i gymnasiet og på HF.

  8. Figuur teeb võidukäiku / Krista Piirimäe

    Index Scriptorium Estoniae

    Piirimäe, Krista, 1946-

    2006-01-01

    Tartu kunstnike aastalõpunäitus Tartu Kunstimajas kuni 22. I. Näituse on kujundanud Maris Palgi ja Rauno Moss. Jaan Punga, Sven Saagi, Albert Gulki, Markus Kasemaa, Saskia Kasemaa, Rauno Mossi, Meiu Mündi, Külli Kalde, Anne Vasara, Piret Mihkelseni, Priit Pajose, Harri Puderselli, Imat Suumanni, Eda Lõhmuse, Sütevaka Andrese, Tiit Tamme, Helle Vahersalu, Malev Toome, Jass Kaselaane, Jaan Luige, Tõnis Paberiti ja Ahti Seppeti töödest

  9. Helicopters in Irregular Warfare: Algeria, Vietnam, and Afghanistan

    Science.gov (United States)

    2013-06-13

    with guns, missiles, and rockets. It is unlikely that aerial artillery won South Vietnamese hearts and minds, but 179Ibid. 180Interview with Stanley...American Struggle for Vietnam’s Hearts and Minds (Boulder, CO: Westview Press, 1995), 33. 217Bruscino, Occasional Paper #17, 37. 218Bruce Palmer... malformed or otherwise ‘reorganized’ is still one hell of a poor instrument with which to engage insurgents.358 — Anonymous U.S. General The

  10. Gateway. Volume 13

    Science.gov (United States)

    2003-01-01

    Unclassified 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Hart, Sandra G ; Drury , Colin G ; Hancock, Peter A ; Szalma, James...interventions, thereby improving threat inspection and, ultimately, homeland security. n For more information please contact: Colin G. Drury , Ph.D. University...at Buffalo, SUNY Department of Industrial Engineering 342 Bell Hell Hall Buffalo, NY 14260 A Unified Model of Security Inspection Colin G. Drury

  11. Hiina kiire majanduskasv kergitab nafta hinda / Lauri Matsulevitsh, Annika Matson

    Index Scriptorium Estoniae

    Matsulevitsh, Lauri

    2005-01-01

    Toornafta hind on praegu rekordiliselt kõrgel tasemel, tõustes 12. augustil Londoni naftabörsil 66,45 dollarini barrelist. Hinnatõusu peamisteks põhjusteks peetakse Pärsia lahe ebastabiilset olukorda ja Aasia kiirest majanduskasvust tingitud tarbimise kasvu. Diagrammid: Nafta hind on aastaga kallinenud poole võrra; Nafta tarbimise järsku kasvu on oodata Aasias. Vt. samas lühiintervjuud Statoil Eesti juht Helle Kirsiga: Bensiini hind jõuab 14 kroonini

  12. 0100101110101101.ORG / Tilman Baumgärtel

    Index Scriptorium Estoniae

    Baumgärtel, Tilman

    2006-01-01

    Veebilehekülje 0100101110101101.ORG taga asuvad itaallased ei soovi oma nimesid avaldada, rühmitus kutsub ennast zero one dot org (01.org). 9. 10. 1999 Pariisis tehtud intervjuu rühmituse liikmetega, keda huvitab kunstiteemaline diskussioon. Võrgukunstnikena tegid nad oma nime tuntuks võrgukunsti galerii "Hell.com" nn vargusega. Nad on oma leheküljele üles pannud Olja Ljalina galerii "art.teleportica" koopia jt. koopiaid. Tööst "Life-Sharing" (2001)

  13. Koos kodus ja tööl / Milla Mägi

    Index Scriptorium Estoniae

    Mägi, Milla, 1949-

    2005-01-01

    Külaskäigust sisearhitektidest abielupaari Helle ja Taevo Gansi koju Nõmmel. Arhitekt August Volbergi projekti järgi 1937. a. valminud funktsionalistlik üherpereelamu on ümber ehitatud kahe pere elamuks. 1988. a. H. ja T. Gansi loodud perefirmast AS Stuudio Gadis, kus töötab ka üks lastest sisearhitekt Riia Oja. H. ja T. Gans oma perekonnast, tööst perefirmas, vana maja kujundamisest jm. 6 värv. ill

  14. Defeating the Modern Asymmetric Threat

    Science.gov (United States)

    2002-06-01

    The warrior caste, for instance, played a role in keeping royalty in check. The highest caste to which Sinhalese could belong was the cultivator...1500s the Tamil kingdom defended the island from Indian encroachment. However, the Tamils would not stop two invasions by a Malaysian 14 Buddhist...king hell bent on capturing the Buddha’s tooth from the Sinhalese. The Malaysians did not succeed, but the Tamil indifference angered the Chinese Ming

  15. Olja Ljalina / Olja Ljalina ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Ljalina, Olja

    2006-01-01

    1997. a. Osnabrückis ja 1998. a. meili teel tehtud intervjuu vene võrgukunstniku Olja Ljalinaga (sünd. 1971). O. Ljalina jõudmisest võrgukunsti juurde, võrgufilmist "My boyfriend came back from the war" (1966), töödest "Anna Karina goes to Paradise" (1996), "Agatha appears" (1997), "Heaven & Hell" (koostöös belgia kunstniku Michael Samyniga). O. Ljalina avas 1998. a. võrgukunsti müügigalerii "art.teleportacia"

  16. Jan Gehli teose "Linnad inimestele" ilmumine = Publication of an Estonian-language Edition of Jan Gehl's Cities for People / Yoko Alender, Liina Teder, Neeme Lopp

    Index Scriptorium Estoniae

    Alender, Yoko, 1979-

    2016-01-01

    Taani arhitektist Jan Gehlist ja tema raamatust "Linnad inimestele". Eestikeelse väljaande toimkond: Yoko Alender, Neeme Lopp, Liina Teder, Eneli Rohtla. Maastikuarhitektuuri aastapreemia nominent 2016

  17. GORLİN - GOLTZ SENDROMU OLGU BİLDİRİSİ-GORLIN-GOLTZ SYNDROME (CASE REPORT)

    OpenAIRE

    Timoçin, Necla; Doğan, Özen

    2013-01-01

    ÖZETGorlin-Goltz sendromu, multipl çene kistleri, bazal hücreli tıevus, bazal hücreli karsînom, iskeletsel anomaliler ve bazı yumuşak doku lezyonlan ile karakterize bir hastalıktır. Sendromun bugüne kadar 40'a yakın bulguları bildirilmiştir. Bu makalede multipl çene kistleri ve tipik yüz görünümlerinden yola çıkılarak incelemeye alınıp,sendroma ait bazı iskeletsel anomalilerin saptanması üzerine Gor-Hn-Goltz Sendromu tanısı konan iki olgu bildirilmektedir.Anahtar sözcükler : Gorlin-Goltz...

  18. PROUČAVANJE RECEPCIJE I POVIJEST ČITANJA (Premda se pojavljuje u 2016., ovaj rad – zapravo pisana verzija izlaganja održanog sredinom 2015. – predstavlja kronološki raniji stadij obrade teme kojom se opsežnije i po mnogo čemu drugačije bavi IX. poglavlje u međuvremenu objavljenoj knjizi David Šporer: Uvod u povijest knjige. Temelji pristupa (Leykam international, Zagreb, 2015.)

    OpenAIRE

    Šporer, David

    2016-01-01

    Članak nudi usporedbu povijesti čitanja i dosadašnjih modela proučavanja recepcije u književnosti, osobito njemačke „estetike recepcije“. Dok se, naime, u domaćim književnoznanstvenim krugovima o njemačkoj „estetici recepcije“ dosta znalo već početkom 1970-ih, to se ne može reći za povijest čitanja koja privlači sve više pažnje posljednjih desetljeća. U radu su zbog toga naznačene određene teme i perspektive karakteristične za povijest čitanja, koje bi mogle biti korisne i u proučavanju knjiž...

  19. Spirocyclopropane-type sesquiterpene hydrocarbons from Schinus terebinthifolius Raddi.

    Science.gov (United States)

    Richter, Rita; von Reuss, Stephan H; König, Wilfried A

    2010-08-01

    The essential oil of Schinus terebinthifolius fruits was reinvestigated using GC and GC-MS techniques. Apart from several known compounds three sesquiterpene hydrocarbons with a carbon skeleton exhibiting the rare spiro(cyclopropane) moiety could be isolated by a combination of column chromatography and GLC. Structure assignments were carried out by NMR spectroscopy. These natural products are 9-spiro(cyclopropa)-4,4,8-trimethyl-2-methylenbicyclo[4.3.0]non-1(6)-ene (terebanene), 9-spiro(cyclopropa)-2,4,4,8-tetramethylbicyclo[4.3.0]nona-1,5-diene (teredenene), and (6R*,8R*)-9-spiro(cyclopropa)-2,4,4,8-tetramethylbicyclo[4.3.0]non-1-ene (terebinthene). Copyright 2010 Elsevier Ltd. All rights reserved.

  20. HOLIDAY FROM HELL : Bad travel experiences of Finnish people

    OpenAIRE

    Miettinen, Milja

    2015-01-01

    The topic of this thesis was the bad travel experiences of Finnish people. This thesis is divided into two parts. The theoretical framework consists of Maslow’s hierarchy of needs, tourism consumer behaviour, experience and experience economy. In the empirical part, a survey was used and answers were collected by a questionnaire on the Internet. The link to the questionnaire was published in Facebook and also on Suomi24 forum’s travel section. It was possible to answer to the questionnai...

  1. Meremaa võluriga päeva kallastele / Helle Leppik

    Index Scriptorium Estoniae

    Leppik, Helle

    1999-01-01

    29. apr. esietendub Ugalas "Meremaa võlur. Päeva kaldad", lavalugu Ursula K. Le Guini Meremaa-lugude alusel, lavastaja Andres Noormets, kunstnikud Silver Vahtre ja Airi Eras, peaosades Margus Vaher, Martin Algus, Aarne Soro, Leila Säälik, Gert Raudsepp, Silvia Sarrap

  2. Eesti ei pea ümberasujatele midagi tagastama / Helle Kalda

    Index Scriptorium Estoniae

    Kalda, Helle, 1950-

    2006-01-01

    Omandireformi aluste seaduse 7 paragrahvi lõikest 3 ja varade tagastamisest nn. järelümberasunutele. Sama ka Meie Maa 12. jaan. 2006, lk. 2 ; Vooremaa 17. jaan. 2006, lk. 2 ; Virumaa Teataja 2. veeb. 2006, lk. 11 ; Pärnu Postimees 9. veeb. 2006, lk. 15 ; Pärnu Postimees 9. veeb. 2006, lk. 15, pealkiri kujul : Ümberasujatele ei pea midagi tagastama

  3. Eesti Muinsuskaitse Seltsi rahvusvaheline koostöö / Helle Solnask

    Index Scriptorium Estoniae

    Solnask, Helle

    2009-01-01

    Osalemisest Euroopa Muinsuskaitsepäevade koordinaatorite töögrupis, HEREIN'is, Europa Nostras, Euroopa Ajalooliste Kalmistute Assotsiatsioonis ASCE, Euroopa Muuseumi- ja Turismiraudteede Föderatsioonis

  4. Ostame maja! / Kersti Pikk, Aet Piel, Piret Tali

    Index Scriptorium Estoniae

    Pikk, Kersti

    2007-01-01

    Võrreldakse kolme eramut - Pirital, Viimsis (Arhitektuuriagentuur OÜ - arhitektid Inga Raukas, Toomas Tammis, Karli Luik ja Renee Puusepp) ja Harku vallas Vatslas. Lk. Oberhausi kinnisvaraspetsialisti Ene Arro kommentaar

  5. Eesti keel eestlaste emotsioonidest / Haldur Õim

    Index Scriptorium Estoniae

    Õim, Haldur, 1942-

    2004-01-01

    Arvustus: Vainik, Ene. Lexical knowledge of emotions: the structure, variability and semantics of the Estonian emotion vocabulary. Tartu : Tartu University Press, 2004. (Dissertationes linguisticae Universitatis Tartuensis ; 5)

  6. Statistical analysis of fragmentation patterns of electron ionization mass spectra of enolized-trimethylsilylated anabolic androgenic steroids

    Science.gov (United States)

    Fragkaki, A. G.; Angelis, Y. S.; Tsantili-Kakoulidou, A.; Koupparis, M.; Georgakopoulos, C.

    2009-08-01

    Anabolic androgenic steroids (AAS) are included in the List of prohibited substances of the World Anti-Doping Agency (WADA) as substances abused to enhance athletic performance. Gas chromatography coupled to mass spectrometry (GC-MS) plays an important role in doping control analyses identifying AAS as their enolized-trimethylsilyl (TMS)-derivatives using the electron ionization (EI) mode. This paper explores the suitability of complementary GC-MS mass spectra and statistical analysis (principal component analysis, PCA and partial least squares-discriminant analysis, PLS-DA) to differentiate AAS as a function of their structural and conformational features expressed by their fragment ions. The results obtained showed that the application of PCA yielded a classification among the AAS molecules which became more apparent after applying PLS-DA to the dataset. The application of PLS-DA yielded a clear separation among the AAS molecules which were, thus, classified as: 1-ene-3-keto, 3-hydroxyl with saturated A-ring, 1-ene-3-hydroxyl, 4-ene-3-keto, 1,4-diene-3-keto and 3-keto with saturated A-ring anabolic steroids. The study of this paper also presents structurally diagnostic fragment ions and dissociation routes providing evidence for the presence of unknown AAS or chemically modified molecules known as designer steroids.

  7. PERSPECTIVAS CURRICULARES SOBRE A FORMAÇÃO DO PEDAGOGO PARA A EDUCAÇÃO NÃO ESCOLAR

    Directory of Open Access Journals (Sweden)

    José Leonardo Rolim de Lima Severo

    2018-03-01

    Full Text Available RESUMO: O artigo apresenta reflexões derivadas de um estudo curricular pautado pelo objetivo de mapear elementos demonstrativos do quadro atual de formação de pedagogos para atuação profissional em contextos de Educação Não Escolar (ENE. O estudo curricular abrangeu Projetos Pedagógicos de Cursos de Pedagogia de 20 universidades públicas brasileiras e os procedimentos analíticos se estruturaram a partir do uso da técnica de análise categorial de conteúdo. O referencial subjacente às análises baseia-se na discussão sobre o caráter epistemológico da Pedagogia e da ENE, bem como na abordagem crítica em torno dos enfoques curriculares que formam tradições do curso de Pedagogia no Brasil. Em vista dos resultados analíticos, se destacam a pouca expressividade de saberes específicos relativos à ENE na configuração curricular dos cursos de Pedagogia e, em consequência, os desafios da estruturação de percursos formativos que dialoguem melhor com demandas de novos âmbitos de inserção profissional do pedagogo.

  8. FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation.

    Directory of Open Access Journals (Sweden)

    Emilios Gemenetzidis

    Full Text Available Cancer associated with smoking and drinking remains a serious health problem worldwide. The survival of patients is very poor due to the lack of effective early biomarkers. FOXM1 overexpression is linked to the majority of human cancers but its mechanism remains unclear in head and neck squamous cell carcinoma (HNSCC.FOXM1 mRNA and protein expressions were investigated in four independent cohorts (total 75 patients consisting of normal, premalignant and HNSCC tissues and cells using quantitative PCR (qPCR, expression microarray, immunohistochemistry and immunocytochemistry. Effect of putative oral carcinogens on FOXM1 transcriptional activity was dose-dependently assayed and confirmed using a FOXM1-specific luciferase reporter system, qPCR, immunoblotting and short-hairpin RNA interference. Genome-wide single nucleotide polymorphism (SNP array was used to 'trace' the genomic instability signature pattern in 8 clonal lines of FOXM1-induced malignant human oral keratinocytes. Furthermore, acute FOXM1 upregulation in primary oral keratinocytes directly induced genomic instability. We have shown for the first time that overexpression of FOXM1 precedes HNSCC malignancy. Screening putative carcinogens in human oral keratinocytes surprisingly showed that nicotine, which is not perceived to be a human carcinogen, directly induced FOXM1 mRNA, protein stabilisation and transcriptional activity at concentrations relevant to tobacco chewers. Importantly, nicotine also augmented FOXM1-induced transformation of human oral keratinocytes. A centrosomal protein CEP55 and a DNA helicase/putative stem cell marker HELLS, both located within a consensus loci (10q23, were found to be novel targets of FOXM1 and their expression correlated tightly with HNSCC progression.This study cautions the potential co-carcinogenic effect of nicotine in tobacco replacement therapies. We hypothesise that aberrant upregulation of FOXM1 may be inducing genomic instability through a

  9. 2008. aastal keskenduti e-teenuste arendamisele : [2008. aasta rahvaraamatukogudes keskraamatukogude aruannete põhjal, tulevikuplaanides] / Meeli Veskus

    Index Scriptorium Estoniae

    Veskus, Meeli, 1953-

    2009-01-01

    Sisaldab ka: Raamatukogude kasutamine, lugejad ja kogud / Margit Jõgi. Lisa: Lugejateenindus ja kogud üldkasutatavates rahvaraamatukogudes 2008 : [joonised] / Margit Jõgi. Milline oli olukord rahvaraamatukogudes 2009. aasta algul? / Ene Riet.

  10. A Review of Chemical Warfare Agent (CWA) Detector Technologies and Commercial-Off-The-Shelf Items

    Science.gov (United States)

    2009-03-01

    Environmental Health Perspectives 1994, 102, 18-38. 21. La Franchi , P., Chemical and Biological Weapons: The War from Hell. ADM September, 1995, pp 9-10...One-to-Five Gas Monitor with VOC Detection. In ENVCO Global . DSTO-GD-0570 98 152. MultiRAE Plus. In RAE Systems: San Jose, CA. 153. ToxiRAE Plus PID...158. Rippen, M., Chemical and Biological Agent Sensor/Detector Systems Technology Development for Applications in the Global War on Terrorism. In

  11. JPRS Report Near East & South Asia, Pakistan.

    Science.gov (United States)

    1993-08-11

    dawn will at last come and rehabilitate us. One wonders when the hell road travelled from the last Election Cell to our present hopelessness will ever...anxiously watch the unfolding political drama as our ruling elite vie for power at the expense of national JPRS-NEA-93-087 11 August 1993 ECONOMIC 47... therapy " and insists on the need for a substantial number of clinical psychologists at the hospitals. According to doctors, acid causes instant damage to

  12. Música medieval al més enllà

    Directory of Open Access Journals (Sweden)

    Toldrà i Vilardell, Albert

    2007-12-01

    Full Text Available According to the Middle Ages anthropomorphic and anachronical conception, in the other world -in heaven and in hell- they play, listen and dance different musics, vochal and instrumental, mystical hymns or torture shapes. There is too a defined and giving legitimation liturgycal and musical collaboration between heaven and earth’s church, which devils try to sabotage. And different heavenly and hellish attitudes, from pleasure to absolut condemnation, towards human musicians and musics.

    No disponible

  13. 7 film om lærerjobbet

    DEFF Research Database (Denmark)

    2010-01-01

    ”Inden man når at få blinket med øjnene, er det faktisk allerede fredag.” Sådan siger Helle Larsen om sit job som lærer nu på. tredje år. I syv små film fortæller lærere, ledere og lærerstuderende om at arbejde i folkeskolen og om at læse til lærer. I filmene beskrives lærerjobbet som værende...

  14. Stridskvinnan Birgitta

    OpenAIRE

    Searby, Denis

    2017-01-01

    “Stridskvinnan Birgitta” focuses on aspects of Birgitta’s writings less palatable to moderntastes, such as images of violent punishment in hell and purgatory. It brings in the exampleof the American Catholic author Flannery O’Connor to illustrate how, from Birgitta’sperspective, violent images could represent an occasion of grace for the recipient of herrevelations. It also discusses Birgitta’s support for the king’s “crusade” to the Baltic countriesfor the purposes of Christianizing them and...

  15. Reincarnation belief and the Christian churches

    OpenAIRE

    Waterhouse, Helen; Walter, Tony

    2003-01-01

    Reincarnation has never been part of mainstream Christian theology. This is true in spite of periodic speculations by Christian theologians, and in spite of the fact that reincarnation believers sometimes wrongly impute belief in reincarnation to prominent Christian thinkers. Even so, in 1984 Paul Badham was able to point to statistics which indicated that as many Anglicans believed in reincarnation as believed in heaven and hell. This paper is based on the responses of the many Christians wh...

  16. Detailed Characterization of Nuclear Recoil Pulse Shape Discrimination in the DarkSide-50 Direct Dark Matter Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Edkins, Erin Elisabeth [Univ. of Hawaii, Honolulu, HI (United States)

    2017-05-01

    While evidence of non-baryonic dark matter has been accumulating for decades, its exact nature continues to remain a mystery. Weakly Interacting Massive Particles (WIMPs) are a well motivated candidate which appear in certain extensions of the Standard Model, independently of dark matter theory. If such particles exist, they should occasionally interact with particles of normal matter, producing a signal which may be detected. The DarkSide-50 direct dark matter experiment aims to detect the energy of recoiling argon atoms due to the elastic scattering of postulated WIMPs. In order to make such a discovery, a clear understanding of both the background and signal region is essential. This understanding requires a careful study of the detector's response to radioactive sources, which in turn requires such sources may be safely introduced into or near the detector volume and reliably removed. The CALibration Insertaion System (CALIS) was designed and built for this purpose in a j oint effort between Fermi National Laboratory and the University of Hawaii. This work describes the design and testing of CALIS, its installation and commissioning at the Laboratori Nazionali del Gran Sasso (LNGS) and the multiple calibration campaigns which have successfully employed it. As nuclear recoils produced by WIMPs are indistinguishable from those produced by neutrons, radiogenic neutrons are both the most dangerous class of background and a vital calibration source for the study of the potential WIMP signal. Prior to the calibration of DarkSide-50 with radioactive neutron sources, the acceptance region was determined by the extrapolation of nuclear recoil data from a separate, dedicated experiment, ScENE, which measured the distribution of the pulse shape discrimination parameter, $f_{90}$, for nuclear recoils of known energies. This work demonstrates the validity of the extrapolation of ScENE values to DarkSide-50, by direct comparison of the $f_{90}$ distributio n of nuclear

  17. Stolitsa baltiskoi modõ / Vladimir Stroi

    Index Scriptorium Estoniae

    Stroi, Vladimir

    2005-01-01

    Riias toimunud Balti moenädalast (Baltic Fashion Week) ja seal näidatud kollektsioonidest. Eestit esindasid Ene (?Evelin) Lill kollektsiooniga "Puudutus" ja Kätlin Kängsepp "Muudatuste uued tuuled"

  18. Halonen arrives for State visit / Ella Karapetyan

    Index Scriptorium Estoniae

    Karapetyan, Ella

    2010-01-01

    Eestis riigivisiidil viibinud Soome president Tarja Halonen kohtus peaminister Andrus Ansipi ja Riigikogu spiikri Ene Ergmaga. Presidendiga visiidil kaasas olnud Soome haridusminister Henna Virkkunen kohtus haridus- ja teadusminister Tõnis Lukasega

  19. ŽENE I SPORT U CRNOJ GORI

    OpenAIRE

    Cheryl Cooky; Marko Begović; Don Sabo; Carole Oglesby; Marj Snyder

    2011-01-01

    This paper is part of a larger study that identifies who plays sport in Montenegro, and the factors (family, education, economic, religious, cultural stereotypes, and so on) that contribute to girls and women’s participation in sport or that limit girls and women’s participation in sport. This study is the first evidencebased research assessing the current status of girls and women’s sport participation in Montenegro, at all institutional levels. Using mixed-methodologies (quantitative assess...

  20. Ülikool ja haridus postajastul / Ene Grauberg

    Index Scriptorium Estoniae

    Grauberg, Ene, 1944-

    2006-01-01

    Informatsiooni kesksest rollist postindustriaalses ühiskonnas, ülikooli ja rakenduskõrgkooli teisenenud funktsioonidest, kõrghariduse uutest trendidest, õppejõu ja üliõpilase suhete muutumisest Pransuse filosoofi Jean-Francois Lyotardi interpreteeringuga